Motif 994 (n=136)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NMY6 | ANXA2P2 | T153 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| K7ELQ4 | ATF7-NPFF | T204 | ochoa | ATF7-NPFF readthrough | None |
| O14908 | GIPC1 | T252 | ochoa | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) | May be involved in G protein-linked signaling. |
| O43182 | ARHGAP6 | T349 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43379 | WDR62 | T1267 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43586 | PSTPIP1 | T346 | ochoa | Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) | Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. {ECO:0000250, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:9857189}. |
| O43822 | CFAP410 | T182 | ochoa | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). {ECO:0000250|UniProtKB:Q8C6G1, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:26290490}. |
| O95359 | TACC2 | T2581 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| P04792 | HSPB1 | T174 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P04818 | TYMS | T170 | psp | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:11278511, ECO:0000269|PubMed:21876188}. |
| P06748 | NPM1 | T234 | ochoa|psp | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:Q61937, ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| P07355 | ANXA2 | T153 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P08172 | CHRM2 | T302 | psp | Muscarinic acetylcholine receptor M2 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| P10966 | CD8B | T140 | ochoa | T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b) | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. {ECO:0000250|UniProtKB:P10300, ECO:0000269|PubMed:10925291, ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:17145893}. |
| P11388 | TOP2A | T1406 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P14317 | HCLS1 | T319 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P15559 | NQO1 | T128 | psp | NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) | Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity) (PubMed:8999809, PubMed:9271353). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (PubMed:15102952, PubMed:8999809, PubMed:9271353). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (PubMed:8999809). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255, PubMed:28291250). {ECO:0000250|UniProtKB:P05982, ECO:0000269|PubMed:15102952, ECO:0000269|PubMed:15687255, ECO:0000269|PubMed:28291250, ECO:0000269|PubMed:8999809, ECO:0000269|PubMed:9271353}. |
| P15884 | TCF4 | T337 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P16144 | ITGB4 | T1471 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P27448 | MARK3 | T602 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P29372 | MPG | T66 | ochoa | DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
| P33991 | MCM4 | T23 | ochoa | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35269 | GTF2F1 | T446 | ochoa | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}. |
| P41235 | HNF4A | T455 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P42331 | ARHGAP25 | T530 | ochoa | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P46821 | MAP1B | T1685 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | T1813 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49023 | PXN | T263 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P54198 | HIRA | T576 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P55011 | SLC12A2 | T217 | ochoa|psp | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P55196 | AFDN | T1101 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55196 | AFDN | T1330 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P78347 | GTF2I | T687 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P85037 | FOXK1 | T436 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| Q00587 | CDC42EP1 | T162 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q00613 | HSF1 | T323 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q01167 | FOXK2 | T389 | ochoa|psp | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q06413 | MEF2C | T450 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q08211 | DHX9 | T107 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q09666 | AHNAK | T38 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T126 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | T490 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12888 | TP53BP1 | T919 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | T1012 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12929 | EPS8 | T499 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13136 | PPFIA1 | T761 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13263 | TRIM28 | T620 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13439 | GOLGA4 | T50 | ochoa | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q13615 | MTMR3 | T618 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q13620 | CUL4B | T85 | ochoa | Cullin-4B (CUL-4B) | Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:16322693, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18235224, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}. |
| Q14004 | CDK13 | T509 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14160 | SCRIB | T936 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14980 | NUMA1 | T211 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14980 | NUMA1 | T1776 | ochoa|psp | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q16204 | CCDC6 | T386 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16204 | CCDC6 | T410 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q2M2Z5 | KIZ | T455 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q4VCS5 | AMOT | T329 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q5JTV8 | TOR1AIP1 | T176 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5M775 | SPECC1 | T812 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T1M5 | FKBP15 | T1146 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5TCX8 | MAP3K21 | T567 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5THJ4 | VPS13D | T1743 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q6WKZ4 | RAB11FIP1 | T358 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZRV2 | FAM83H | T1014 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q71RC2 | LARP4 | T588 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q7L9B9 | EEPD1 | T239 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7LBC6 | KDM3B | T746 | ochoa | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
| Q7Z2W4 | ZC3HAV1 | T375 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z460 | CLASP1 | T1104 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q86U86 | PBRM1 | T43 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86VP1 | TAX1BP1 | T702 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86XZ4 | SPATS2 | T405 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q86YW5 | TREML1 | T283 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IUW5 | RELL1 | T182 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
| Q8IWB9 | TEX2 | T181 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8NF91 | SYNE1 | T8274 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NFH8 | REPS2 | T479 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8TAQ2 | SMARCC2 | T322 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8WWI1 | LMO7 | T979 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWI1 | LMO7 | T1007 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWI1 | LMO7 | T1583 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WYP5 | AHCTF1 | T1229 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92540 | SMG7 | T539 | ochoa | Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}. |
| Q92738 | USP6NL | T705 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q92925 | SMARCD2 | T221 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036). {ECO:0000269|PubMed:28369036, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96A22 | C11orf52 | T105 | ochoa | Uncharacterized protein C11orf52 | None |
| Q96A32 | MYL11 | T35 | ochoa | Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform) | Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity). {ECO:0000250|UniProtKB:O93409}. |
| Q96D71 | REPS1 | T448 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96JY6 | PDLIM2 | T91 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96KQ7 | EHMT2 | T135 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96N67 | DOCK7 | T878 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96QT4 | TRPM7 | T1482 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96QT4 | TRPM7 | T1508 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96SU4 | OSBPL9 | T335 | ochoa | Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9) | Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269|PubMed:39106189}. |
| Q99081 | TCF12 | T352 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q9BRD0 | BUD13 | T255 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BTC0 | DIDO1 | T1733 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BX66 | SORBS1 | T344 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9GZY8 | MFF | T115 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H8N7 | ZNF395 | T257 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9HB20 | PLEKHA3 | T231 | ochoa | Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) | Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}. |
| Q9HCK8 | CHD8 | T2037 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NQG6 | MIEF1 | T89 | ochoa | Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein) | Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics (PubMed:21701560, PubMed:23921378, PubMed:33632269). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24515348, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33632269}. |
| Q9NQS7 | INCENP | T509 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NXR1 | NDE1 | T243 | ochoa|psp | Nuclear distribution protein nudE homolog 1 (NudE) | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}. |
| Q9P0K7 | RAI14 | T424 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P107 | GMIP | T457 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P219 | CCDC88C | T1460 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9UBU9 | NXF1 | T576 | ochoa | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}. |
| Q9UHD8 | SEPTIN9 | T49 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UMZ2 | SYNRG | T1100 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UNF0 | PACSIN2 | T391 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
| Q9UPQ0 | LIMCH1 | T667 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9Y2F5 | ICE1 | T1907 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2K7 | KDM2A | T737 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y2W1 | THRAP3 | T397 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y2X7 | GIT1 | T601 | ochoa | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y3B9 | RRP15 | T104 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y4G8 | RAPGEF2 | T602 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y520 | PRRC2C | T1265 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y6Q9 | NCOA3 | T1059 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9Y6R4 | MAP3K4 | T1271 | ochoa | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) | Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. |
| P14618 | PKM | T87 | Sugiyama | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P60174 | TPI1 | T214 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P07814 | EPRS1 | T707 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| Q9BY44 | EIF2A | T522 | Sugiyama | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}. |
| O60664 | PLIN3 | T145 | Sugiyama | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O43602 | DCX | T326 | SIGNOR|iPTMNet | Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}. |
| Q04721 | NOTCH2 | T132 | Sugiyama | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q15349 | RPS6KA2 | T698 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q9H4L7 | SMARCAD1 | T231 | Sugiyama | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| P07437 | TUBB | T290 | Sugiyama | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| O15355 | PPM1G | T234 | Sugiyama | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| Q9NYF8 | BCLAF1 | T304 | Sugiyama | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q16643 | DBN1 | T161 | Sugiyama | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.000694 | 3.158 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.000360 | 3.444 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.002050 | 2.688 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.003245 | 2.489 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.003245 | 2.489 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.002755 | 2.560 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.004107 | 2.386 |
| R-HSA-525793 | Myogenesis | 0.003546 | 2.450 |
| R-HSA-1640170 | Cell Cycle | 0.003718 | 2.430 |
| R-HSA-186712 | Regulation of beta-cell development | 0.003840 | 2.416 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 0.018581 | 1.731 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 0.027742 | 1.557 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.027742 | 1.557 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.011373 | 1.944 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.014034 | 1.853 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.023428 | 1.630 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.012270 | 1.911 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.012270 | 1.911 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.029775 | 1.526 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.029775 | 1.526 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.013619 | 1.866 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.021148 | 1.675 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.022395 | 1.650 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 0.027742 | 1.557 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.014034 | 1.853 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.015408 | 1.812 |
| R-HSA-68877 | Mitotic Prometaphase | 0.015431 | 1.812 |
| R-HSA-198753 | ERK/MAPK targets | 0.025187 | 1.599 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.014681 | 1.833 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.028726 | 1.542 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.006120 | 2.213 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.027826 | 1.556 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.020072 | 1.697 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.023428 | 1.630 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.013287 | 1.877 |
| R-HSA-9831926 | Nephron development | 0.020072 | 1.697 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.023035 | 1.638 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.019786 | 1.704 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.020072 | 1.697 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.021676 | 1.664 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.006736 | 2.172 |
| R-HSA-1266738 | Developmental Biology | 0.027287 | 1.564 |
| R-HSA-162582 | Signal Transduction | 0.022779 | 1.642 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.054719 | 1.262 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.054719 | 1.262 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.063545 | 1.197 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 0.072290 | 1.141 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.080953 | 1.092 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.089536 | 1.048 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.089536 | 1.048 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.089536 | 1.048 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.089536 | 1.048 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.089536 | 1.048 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.098039 | 1.009 |
| R-HSA-444257 | RSK activation | 0.098039 | 1.009 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.098039 | 1.009 |
| R-HSA-9613354 | Lipophagy | 0.106463 | 0.973 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.106463 | 0.973 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.114809 | 0.940 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.131270 | 0.882 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.139386 | 0.856 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.147426 | 0.831 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.163284 | 0.787 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.163284 | 0.787 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.052406 | 1.281 |
| R-HSA-3371511 | HSF1 activation | 0.062201 | 1.206 |
| R-HSA-3371568 | Attenuation phase | 0.072561 | 1.139 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.201659 | 0.695 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.201659 | 0.695 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.201659 | 0.695 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.033043 | 1.481 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.041361 | 1.383 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.223839 | 0.650 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.223839 | 0.650 |
| R-HSA-380287 | Centrosome maturation | 0.043914 | 1.357 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.231095 | 0.636 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.238284 | 0.623 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.238284 | 0.623 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.106499 | 0.973 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.127898 | 0.893 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.266379 | 0.574 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.266379 | 0.574 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.134187 | 0.872 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.273240 | 0.563 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.273240 | 0.563 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.273240 | 0.563 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.273240 | 0.563 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.280038 | 0.553 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.150197 | 0.823 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.216514 | 0.665 |
| R-HSA-72086 | mRNA Capping | 0.280038 | 0.553 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.067039 | 1.174 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.286772 | 0.542 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.131270 | 0.882 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.178849 | 0.748 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.224044 | 0.650 |
| R-HSA-4641265 | Repression of WNT target genes | 0.139386 | 0.856 |
| R-HSA-3928664 | Ephrin signaling | 0.194126 | 0.712 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.217180 | 0.663 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.065918 | 1.181 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.265478 | 0.576 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.036818 | 1.434 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.045810 | 1.339 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.098039 | 1.009 |
| R-HSA-176974 | Unwinding of DNA | 0.106463 | 0.973 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.194126 | 0.712 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.201659 | 0.695 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.231095 | 0.636 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.245407 | 0.610 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.163266 | 0.787 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.286236 | 0.543 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.194126 | 0.712 |
| R-HSA-9620244 | Long-term potentiation | 0.252463 | 0.598 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 0.063545 | 1.197 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.114809 | 0.940 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.231095 | 0.636 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.259454 | 0.586 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.300054 | 0.523 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.107923 | 0.967 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.098342 | 1.007 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.107923 | 0.967 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.206923 | 0.684 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.220782 | 0.656 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.106463 | 0.973 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.123078 | 0.910 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.147426 | 0.831 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.216514 | 0.665 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.245407 | 0.610 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.245407 | 0.610 |
| R-HSA-1221632 | Meiotic synapsis | 0.112509 | 0.949 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.056343 | 1.249 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.266379 | 0.574 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.300054 | 0.523 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.062348 | 1.205 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.039074 | 1.408 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.300054 | 0.523 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.214561 | 0.668 |
| R-HSA-9733709 | Cardiogenesis | 0.052406 | 1.281 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.064740 | 1.189 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.194126 | 0.712 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.113839 | 0.944 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.090941 | 1.041 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.204899 | 0.688 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.123110 | 0.910 |
| R-HSA-199920 | CREB phosphorylation | 0.080953 | 1.092 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.089536 | 1.048 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.089536 | 1.048 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.089536 | 1.048 |
| R-HSA-9839394 | TGFBR3 expression | 0.034741 | 1.459 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.223839 | 0.650 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.238284 | 0.623 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.259454 | 0.586 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.093076 | 1.031 |
| R-HSA-3214842 | HDMs demethylate histones | 0.034741 | 1.459 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.193334 | 0.714 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.075232 | 1.124 |
| R-HSA-4839726 | Chromatin organization | 0.042116 | 1.376 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.201659 | 0.695 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.072290 | 1.141 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.155392 | 0.809 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.186523 | 0.729 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.094611 | 1.024 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.043232 | 1.364 |
| R-HSA-68882 | Mitotic Anaphase | 0.182054 | 0.740 |
| R-HSA-5689603 | UCH proteinases | 0.186586 | 0.729 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.183915 | 0.735 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.275052 | 0.561 |
| R-HSA-195721 | Signaling by WNT | 0.180000 | 0.745 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.089041 | 1.050 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.262319 | 0.581 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.106463 | 0.973 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.171103 | 0.767 |
| R-HSA-9612973 | Autophagy | 0.224319 | 0.649 |
| R-HSA-68886 | M Phase | 0.179059 | 0.747 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.209121 | 0.680 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.223839 | 0.650 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.238284 | 0.623 |
| R-HSA-69206 | G1/S Transition | 0.145146 | 0.838 |
| R-HSA-447043 | Neurofascin interactions | 0.080953 | 1.092 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.186523 | 0.729 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.259454 | 0.586 |
| R-HSA-3295583 | TRP channels | 0.259454 | 0.586 |
| R-HSA-2028269 | Signaling by Hippo | 0.186523 | 0.729 |
| R-HSA-69190 | DNA strand elongation | 0.300054 | 0.523 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.048002 | 1.319 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.239192 | 0.621 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.089536 | 1.048 |
| R-HSA-1500620 | Meiosis | 0.217180 | 0.663 |
| R-HSA-9663891 | Selective autophagy | 0.230924 | 0.637 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.037678 | 1.424 |
| R-HSA-397014 | Muscle contraction | 0.174677 | 0.758 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.171103 | 0.767 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.216514 | 0.665 |
| R-HSA-2559583 | Cellular Senescence | 0.286894 | 0.542 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.033364 | 1.477 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.040114 | 1.397 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.114809 | 0.940 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.163284 | 0.787 |
| R-HSA-9833482 | PKR-mediated signaling | 0.050631 | 1.296 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.217180 | 0.663 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.134187 | 0.872 |
| R-HSA-450294 | MAP kinase activation | 0.137357 | 0.862 |
| R-HSA-180292 | GAB1 signalosome | 0.194126 | 0.712 |
| R-HSA-1483255 | PI Metabolism | 0.090941 | 1.041 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.290971 | 0.536 |
| R-HSA-70171 | Glycolysis | 0.087332 | 1.059 |
| R-HSA-446728 | Cell junction organization | 0.062833 | 1.202 |
| R-HSA-448424 | Interleukin-17 signaling | 0.166565 | 0.778 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.194126 | 0.712 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.223839 | 0.650 |
| R-HSA-1632852 | Macroautophagy | 0.185904 | 0.731 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.068638 | 1.163 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.293444 | 0.532 |
| R-HSA-1500931 | Cell-Cell communication | 0.097701 | 1.010 |
| R-HSA-70326 | Glucose metabolism | 0.126031 | 0.900 |
| R-HSA-1538133 | G0 and Early G1 | 0.050052 | 1.301 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.054799 | 1.261 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.231095 | 0.636 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.166565 | 0.778 |
| R-HSA-3000170 | Syndecan interactions | 0.238284 | 0.623 |
| R-HSA-3000157 | Laminin interactions | 0.252463 | 0.598 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.104047 | 0.983 |
| R-HSA-70268 | Pyruvate metabolism | 0.227482 | 0.643 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.300054 | 0.523 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.259454 | 0.586 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.219429 | 0.659 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.201659 | 0.695 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.169876 | 0.770 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.105978 | 0.975 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.127898 | 0.893 |
| R-HSA-418990 | Adherens junctions interactions | 0.185782 | 0.731 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.151720 | 0.819 |
| R-HSA-421270 | Cell-cell junction organization | 0.250418 | 0.601 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.123078 | 0.910 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.113839 | 0.944 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.119877 | 0.921 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.272400 | 0.565 |
| R-HSA-190236 | Signaling by FGFR | 0.272400 | 0.565 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.272400 | 0.565 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.272400 | 0.565 |
| R-HSA-9830369 | Kidney development | 0.156705 | 0.805 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.062201 | 1.206 |
| R-HSA-622312 | Inflammasomes | 0.273240 | 0.563 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.280038 | 0.553 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.234164 | 0.630 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.189956 | 0.721 |
| R-HSA-166520 | Signaling by NTRKs | 0.204899 | 0.688 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.200936 | 0.697 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.150197 | 0.823 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.245561 | 0.610 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.241270 | 0.617 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.186586 | 0.729 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.227482 | 0.643 |
| R-HSA-69275 | G2/M Transition | 0.302168 | 0.520 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.306602 | 0.513 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.306602 | 0.513 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.306602 | 0.513 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.306936 | 0.513 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.306936 | 0.513 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.307269 | 0.512 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.308482 | 0.511 |
| R-HSA-5617833 | Cilium Assembly | 0.312375 | 0.505 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.313090 | 0.504 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.313090 | 0.504 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.314928 | 0.502 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.319517 | 0.496 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.319517 | 0.496 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.319517 | 0.496 |
| R-HSA-5673000 | RAF activation | 0.319517 | 0.496 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.319517 | 0.496 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.322592 | 0.491 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.325885 | 0.487 |
| R-HSA-381042 | PERK regulates gene expression | 0.325885 | 0.487 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.327702 | 0.485 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.332193 | 0.479 |
| R-HSA-163560 | Triglyceride catabolism | 0.332193 | 0.479 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.332193 | 0.479 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.337922 | 0.471 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.338443 | 0.471 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.338443 | 0.471 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.341161 | 0.467 |
| R-HSA-373760 | L1CAM interactions | 0.344557 | 0.463 |
| R-HSA-73927 | Depurination | 0.344634 | 0.463 |
| R-HSA-8875878 | MET promotes cell motility | 0.344634 | 0.463 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.344634 | 0.463 |
| R-HSA-72172 | mRNA Splicing | 0.350684 | 0.455 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.350768 | 0.455 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.350768 | 0.455 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.350768 | 0.455 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.350768 | 0.455 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.350768 | 0.455 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.350768 | 0.455 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.354713 | 0.450 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.354713 | 0.450 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.356845 | 0.448 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.356845 | 0.448 |
| R-HSA-167169 | HIV Transcription Elongation | 0.356845 | 0.448 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.356845 | 0.448 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.356845 | 0.448 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.356845 | 0.448 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.356845 | 0.448 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.356845 | 0.448 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.356845 | 0.448 |
| R-HSA-5260271 | Diseases of Immune System | 0.356845 | 0.448 |
| R-HSA-9646399 | Aggrephagy | 0.356845 | 0.448 |
| R-HSA-3371556 | Cellular response to heat stress | 0.361453 | 0.442 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.361453 | 0.442 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.362866 | 0.440 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.362866 | 0.440 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.364813 | 0.438 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.364813 | 0.438 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.368830 | 0.433 |
| R-HSA-167161 | HIV Transcription Initiation | 0.368830 | 0.433 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.368830 | 0.433 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.368830 | 0.433 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.368830 | 0.433 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.368830 | 0.433 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.368830 | 0.433 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.371047 | 0.431 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.371514 | 0.430 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.374739 | 0.426 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.374739 | 0.426 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.374739 | 0.426 |
| R-HSA-194138 | Signaling by VEGF | 0.378186 | 0.422 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.380593 | 0.420 |
| R-HSA-69481 | G2/M Checkpoints | 0.384830 | 0.415 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.386393 | 0.413 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.386393 | 0.413 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.392138 | 0.407 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.392138 | 0.407 |
| R-HSA-774815 | Nucleosome assembly | 0.392138 | 0.407 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.392138 | 0.407 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.395300 | 0.403 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.397830 | 0.400 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.397830 | 0.400 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.397830 | 0.400 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.397830 | 0.400 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.397830 | 0.400 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.397830 | 0.400 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.397830 | 0.400 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.397830 | 0.400 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.397830 | 0.400 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.397830 | 0.400 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.397830 | 0.400 |
| R-HSA-1474165 | Reproduction | 0.398024 | 0.400 |
| R-HSA-9843745 | Adipogenesis | 0.401303 | 0.397 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.401632 | 0.396 |
| R-HSA-437239 | Recycling pathway of L1 | 0.403470 | 0.394 |
| R-HSA-162906 | HIV Infection | 0.408884 | 0.388 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.409056 | 0.388 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.409056 | 0.388 |
| R-HSA-70263 | Gluconeogenesis | 0.409056 | 0.388 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.409056 | 0.388 |
| R-HSA-73893 | DNA Damage Bypass | 0.414591 | 0.382 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.420075 | 0.377 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.420796 | 0.376 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.420796 | 0.376 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.430888 | 0.366 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.430888 | 0.366 |
| R-HSA-8939211 | ESR-mediated signaling | 0.433740 | 0.363 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.436220 | 0.360 |
| R-HSA-199991 | Membrane Trafficking | 0.438420 | 0.358 |
| R-HSA-157118 | Signaling by NOTCH | 0.441125 | 0.355 |
| R-HSA-72649 | Translation initiation complex formation | 0.441502 | 0.355 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.441502 | 0.355 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.451919 | 0.345 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.451919 | 0.345 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.451919 | 0.345 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.451919 | 0.345 |
| R-HSA-75893 | TNF signaling | 0.451919 | 0.345 |
| R-HSA-177929 | Signaling by EGFR | 0.451919 | 0.345 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.457055 | 0.340 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.462143 | 0.335 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.462143 | 0.335 |
| R-HSA-6798695 | Neutrophil degranulation | 0.465907 | 0.332 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.467184 | 0.331 |
| R-HSA-8979227 | Triglyceride metabolism | 0.467184 | 0.331 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.467184 | 0.331 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.471126 | 0.327 |
| R-HSA-379724 | tRNA Aminoacylation | 0.472178 | 0.326 |
| R-HSA-351202 | Metabolism of polyamines | 0.472178 | 0.326 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.477125 | 0.321 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.482026 | 0.317 |
| R-HSA-9707616 | Heme signaling | 0.482026 | 0.317 |
| R-HSA-1989781 | PPARA activates gene expression | 0.483301 | 0.316 |
| R-HSA-8848021 | Signaling by PTK6 | 0.486882 | 0.313 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.486882 | 0.313 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.489324 | 0.310 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.491692 | 0.308 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.501179 | 0.300 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.501179 | 0.300 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.505856 | 0.296 |
| R-HSA-167172 | Transcription of the HIV genome | 0.510489 | 0.292 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.510489 | 0.292 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.519628 | 0.284 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.519628 | 0.284 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.524133 | 0.281 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.524133 | 0.281 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.528596 | 0.277 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.528596 | 0.277 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.533018 | 0.273 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.533018 | 0.273 |
| R-HSA-4086398 | Ca2+ pathway | 0.533018 | 0.273 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.537399 | 0.270 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.537399 | 0.270 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.537399 | 0.270 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.537399 | 0.270 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.538713 | 0.269 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.538713 | 0.269 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.541738 | 0.266 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.541738 | 0.266 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.546038 | 0.263 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.554516 | 0.256 |
| R-HSA-4086400 | PCP/CE pathway | 0.554516 | 0.256 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.554516 | 0.256 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.555481 | 0.255 |
| R-HSA-9659379 | Sensory processing of sound | 0.558697 | 0.253 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.562838 | 0.250 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.562838 | 0.250 |
| R-HSA-6806834 | Signaling by MET | 0.562838 | 0.250 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.566940 | 0.246 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.566940 | 0.246 |
| R-HSA-1483257 | Phospholipid metabolism | 0.568524 | 0.245 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.570675 | 0.244 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.571005 | 0.243 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.579020 | 0.237 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.579020 | 0.237 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.582972 | 0.234 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.605920 | 0.218 |
| R-HSA-73884 | Base Excision Repair | 0.605920 | 0.218 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.616919 | 0.210 |
| R-HSA-168249 | Innate Immune System | 0.619171 | 0.208 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.620518 | 0.207 |
| R-HSA-212436 | Generic Transcription Pathway | 0.621487 | 0.207 |
| R-HSA-1474290 | Collagen formation | 0.624082 | 0.205 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.627614 | 0.202 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.638011 | 0.195 |
| R-HSA-2262752 | Cellular responses to stress | 0.644401 | 0.191 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.644782 | 0.191 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.648120 | 0.188 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.650956 | 0.186 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.651427 | 0.186 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.657949 | 0.182 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.660284 | 0.180 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.661164 | 0.180 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.661164 | 0.180 |
| R-HSA-8951664 | Neddylation | 0.662031 | 0.179 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.664267 | 0.178 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.664349 | 0.178 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.664349 | 0.178 |
| R-HSA-9833110 | RSV-host interactions | 0.664349 | 0.178 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.667505 | 0.176 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.670631 | 0.174 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.671228 | 0.173 |
| R-HSA-69239 | Synthesis of DNA | 0.673728 | 0.172 |
| R-HSA-112316 | Neuronal System | 0.675918 | 0.170 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.676795 | 0.170 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.676795 | 0.170 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.676795 | 0.170 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.676795 | 0.170 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.679466 | 0.168 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.679835 | 0.168 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.682845 | 0.166 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.688783 | 0.162 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.688783 | 0.162 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.688783 | 0.162 |
| R-HSA-73894 | DNA Repair | 0.694062 | 0.159 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.694610 | 0.158 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.694610 | 0.158 |
| R-HSA-8953854 | Metabolism of RNA | 0.696621 | 0.157 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.705941 | 0.151 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.705941 | 0.151 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.708708 | 0.150 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.708708 | 0.150 |
| R-HSA-5693538 | Homology Directed Repair | 0.711449 | 0.148 |
| R-HSA-68875 | Mitotic Prophase | 0.716854 | 0.145 |
| R-HSA-73886 | Chromosome Maintenance | 0.719519 | 0.143 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.724774 | 0.140 |
| R-HSA-5688426 | Deubiquitination | 0.731134 | 0.136 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.732474 | 0.135 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.732474 | 0.135 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.732474 | 0.135 |
| R-HSA-913531 | Interferon Signaling | 0.732904 | 0.135 |
| R-HSA-9909396 | Circadian clock | 0.751977 | 0.124 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.754229 | 0.122 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.765671 | 0.116 |
| R-HSA-5368287 | Mitochondrial translation | 0.767879 | 0.115 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.770066 | 0.113 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.778613 | 0.109 |
| R-HSA-74160 | Gene expression (Transcription) | 0.779186 | 0.108 |
| R-HSA-422475 | Axon guidance | 0.780595 | 0.108 |
| R-HSA-69242 | S Phase | 0.790846 | 0.102 |
| R-HSA-9758941 | Gastrulation | 0.792818 | 0.101 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.794772 | 0.100 |
| R-HSA-72766 | Translation | 0.796459 | 0.099 |
| R-HSA-69306 | DNA Replication | 0.800525 | 0.097 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.800525 | 0.097 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.802406 | 0.096 |
| R-HSA-73887 | Death Receptor Signaling | 0.802406 | 0.096 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.804270 | 0.095 |
| R-HSA-162587 | HIV Life Cycle | 0.807946 | 0.093 |
| R-HSA-9711097 | Cellular response to starvation | 0.809759 | 0.092 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.813332 | 0.090 |
| R-HSA-109581 | Apoptosis | 0.816839 | 0.088 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.820280 | 0.086 |
| R-HSA-9675108 | Nervous system development | 0.820510 | 0.086 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.826497 | 0.083 |
| R-HSA-72306 | tRNA processing | 0.831827 | 0.080 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.834988 | 0.078 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.839620 | 0.076 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.839620 | 0.076 |
| R-HSA-168255 | Influenza Infection | 0.845596 | 0.073 |
| R-HSA-3781865 | Diseases of glycosylation | 0.852755 | 0.069 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.854546 | 0.068 |
| R-HSA-449147 | Signaling by Interleukins | 0.859245 | 0.066 |
| R-HSA-983712 | Ion channel transport | 0.859585 | 0.066 |
| R-HSA-9609690 | HCMV Early Events | 0.868620 | 0.061 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.873522 | 0.059 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.877078 | 0.057 |
| R-HSA-5357801 | Programmed Cell Death | 0.880535 | 0.055 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.894212 | 0.049 |
| R-HSA-15869 | Metabolism of nucleotides | 0.911064 | 0.040 |
| R-HSA-9609646 | HCMV Infection | 0.922175 | 0.035 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.926504 | 0.033 |
| R-HSA-416476 | G alpha (q) signalling events | 0.931906 | 0.031 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.942111 | 0.026 |
| R-HSA-9658195 | Leishmania infection | 0.942111 | 0.026 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.942662 | 0.026 |
| R-HSA-168256 | Immune System | 0.955577 | 0.020 |
| R-HSA-8957322 | Metabolism of steroids | 0.961638 | 0.017 |
| R-HSA-9824446 | Viral Infection Pathways | 0.962056 | 0.017 |
| R-HSA-1474244 | Extracellular matrix organization | 0.964127 | 0.016 |
| R-HSA-9679506 | SARS-CoV Infections | 0.973026 | 0.012 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.978435 | 0.009 |
| R-HSA-597592 | Post-translational protein modification | 0.980187 | 0.009 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.980601 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.981153 | 0.008 |
| R-HSA-418594 | G alpha (i) signalling events | 0.982884 | 0.007 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.983990 | 0.007 |
| R-HSA-5668914 | Diseases of metabolism | 0.985885 | 0.006 |
| R-HSA-556833 | Metabolism of lipids | 0.989925 | 0.004 |
| R-HSA-1280218 | Adaptive Immune System | 0.991390 | 0.004 |
| R-HSA-392499 | Metabolism of proteins | 0.993660 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 0.995770 | 0.002 |
| R-HSA-109582 | Hemostasis | 0.996123 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.996273 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 0.997065 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.997359 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.997957 | 0.001 |
| R-HSA-1643685 | Disease | 0.998823 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999995 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.851 | 0.092 | 1 | 0.803 |
VRK2 |
0.840 | -0.013 | 1 | 0.855 |
GCK |
0.840 | 0.067 | 1 | 0.765 |
TNIK |
0.838 | 0.043 | 3 | 0.768 |
TAK1 |
0.837 | -0.024 | 1 | 0.781 |
PKR |
0.837 | 0.015 | 1 | 0.817 |
JNK2 |
0.837 | 0.320 | 1 | 0.770 |
JNK3 |
0.837 | 0.312 | 1 | 0.792 |
LKB1 |
0.835 | 0.076 | -3 | 0.856 |
PRP4 |
0.835 | 0.288 | -3 | 0.845 |
MEKK2 |
0.834 | 0.021 | 2 | 0.737 |
TTK |
0.834 | 0.011 | -2 | 0.748 |
MINK |
0.833 | -0.021 | 1 | 0.751 |
MPSK1 |
0.833 | 0.140 | 1 | 0.787 |
KHS2 |
0.832 | 0.065 | 1 | 0.761 |
KHS1 |
0.832 | 0.037 | 1 | 0.747 |
LRRK2 |
0.832 | -0.097 | 2 | 0.777 |
P38B |
0.832 | 0.312 | 1 | 0.767 |
TAO3 |
0.831 | 0.047 | 1 | 0.759 |
VRK1 |
0.831 | -0.120 | 2 | 0.763 |
MOS |
0.830 | 0.189 | 1 | 0.833 |
HGK |
0.830 | -0.002 | 3 | 0.773 |
EEF2K |
0.830 | -0.002 | 3 | 0.758 |
OSR1 |
0.830 | 0.015 | 2 | 0.732 |
P38A |
0.830 | 0.278 | 1 | 0.822 |
NEK5 |
0.829 | -0.003 | 1 | 0.784 |
PASK |
0.829 | 0.129 | -3 | 0.851 |
BRAF |
0.828 | -0.053 | -4 | 0.773 |
NEK1 |
0.828 | -0.086 | 1 | 0.752 |
MST3 |
0.827 | 0.041 | 2 | 0.759 |
MST2 |
0.827 | -0.053 | 1 | 0.767 |
ASK1 |
0.827 | -0.129 | 1 | 0.709 |
ALK4 |
0.827 | 0.077 | -2 | 0.820 |
MEK5 |
0.826 | -0.137 | 2 | 0.757 |
PDK1 |
0.826 | -0.064 | 1 | 0.728 |
BMPR2 |
0.826 | -0.062 | -2 | 0.835 |
HPK1 |
0.826 | 0.003 | 1 | 0.746 |
ALPHAK3 |
0.825 | -0.014 | -1 | 0.754 |
NLK |
0.825 | 0.228 | 1 | 0.890 |
CAMKK2 |
0.825 | -0.035 | -2 | 0.729 |
NIK |
0.825 | -0.036 | -3 | 0.854 |
MST1 |
0.825 | -0.080 | 1 | 0.749 |
MAP3K15 |
0.825 | -0.073 | 1 | 0.725 |
TAO2 |
0.825 | -0.090 | 2 | 0.781 |
MYO3B |
0.824 | -0.021 | 2 | 0.759 |
P38G |
0.824 | 0.306 | 1 | 0.718 |
BMPR1B |
0.824 | 0.178 | 1 | 0.744 |
MEK1 |
0.823 | -0.148 | 2 | 0.780 |
DAPK2 |
0.823 | -0.025 | -3 | 0.836 |
P38D |
0.823 | 0.316 | 1 | 0.747 |
ATR |
0.822 | 0.108 | 1 | 0.815 |
HIPK1 |
0.822 | 0.266 | 1 | 0.864 |
MYO3A |
0.822 | -0.056 | 1 | 0.768 |
CDK1 |
0.821 | 0.326 | 1 | 0.784 |
MAK |
0.821 | 0.256 | -2 | 0.761 |
ICK |
0.821 | 0.152 | -3 | 0.816 |
LATS1 |
0.820 | 0.089 | -3 | 0.860 |
CAMLCK |
0.820 | -0.022 | -2 | 0.806 |
CAMKK1 |
0.819 | -0.104 | -2 | 0.729 |
PBK |
0.819 | 0.003 | 1 | 0.738 |
PRPK |
0.819 | -0.045 | -1 | 0.841 |
GRK7 |
0.819 | 0.167 | 1 | 0.709 |
DLK |
0.819 | -0.059 | 1 | 0.782 |
SKMLCK |
0.819 | 0.128 | -2 | 0.825 |
ALK2 |
0.819 | 0.071 | -2 | 0.800 |
NEK8 |
0.819 | -0.096 | 2 | 0.742 |
CLK3 |
0.819 | 0.334 | 1 | 0.876 |
MEKK6 |
0.818 | -0.111 | 1 | 0.767 |
MEKK1 |
0.818 | -0.115 | 1 | 0.778 |
BIKE |
0.818 | -0.021 | 1 | 0.694 |
ANKRD3 |
0.818 | -0.075 | 1 | 0.804 |
JNK1 |
0.817 | 0.268 | 1 | 0.755 |
MEKK3 |
0.817 | -0.041 | 1 | 0.761 |
TLK2 |
0.817 | 0.114 | 1 | 0.796 |
YSK1 |
0.817 | -0.078 | 2 | 0.738 |
NEK4 |
0.817 | -0.111 | 1 | 0.754 |
CDKL1 |
0.816 | 0.065 | -3 | 0.771 |
NEK11 |
0.816 | -0.116 | 1 | 0.742 |
DYRK2 |
0.816 | 0.289 | 1 | 0.859 |
CDK5 |
0.815 | 0.274 | 1 | 0.833 |
ERK1 |
0.814 | 0.283 | 1 | 0.763 |
YSK4 |
0.814 | -0.060 | 1 | 0.730 |
ROCK2 |
0.813 | 0.035 | -3 | 0.767 |
ZAK |
0.813 | -0.072 | 1 | 0.740 |
DMPK1 |
0.813 | 0.028 | -3 | 0.714 |
STLK3 |
0.813 | -0.167 | 1 | 0.710 |
CAMK1B |
0.812 | -0.027 | -3 | 0.821 |
TGFBR1 |
0.812 | 0.073 | -2 | 0.792 |
ERK2 |
0.812 | 0.232 | 1 | 0.792 |
ERK5 |
0.812 | 0.141 | 1 | 0.824 |
DAPK3 |
0.812 | -0.010 | -3 | 0.773 |
MLK2 |
0.810 | -0.020 | 2 | 0.758 |
LOK |
0.810 | -0.057 | -2 | 0.716 |
MOK |
0.809 | 0.199 | 1 | 0.854 |
COT |
0.809 | 0.194 | 2 | 0.809 |
AAK1 |
0.808 | 0.023 | 1 | 0.605 |
CHAK2 |
0.808 | 0.099 | -1 | 0.863 |
GRK5 |
0.807 | 0.037 | -3 | 0.847 |
BMPR1A |
0.807 | 0.111 | 1 | 0.728 |
RAF1 |
0.807 | -0.055 | 1 | 0.792 |
ACVR2B |
0.807 | 0.034 | -2 | 0.762 |
HIPK2 |
0.807 | 0.306 | 1 | 0.798 |
ACVR2A |
0.806 | 0.024 | -2 | 0.745 |
SLK |
0.806 | -0.020 | -2 | 0.682 |
GRK6 |
0.805 | 0.043 | 1 | 0.774 |
HIPK4 |
0.805 | 0.251 | 1 | 0.897 |
MEK2 |
0.805 | -0.280 | 2 | 0.757 |
MLK3 |
0.805 | 0.073 | 2 | 0.676 |
MLK1 |
0.804 | -0.025 | 2 | 0.741 |
SMMLCK |
0.804 | -0.076 | -3 | 0.778 |
BUB1 |
0.804 | 0.091 | -5 | 0.787 |
HIPK3 |
0.803 | 0.201 | 1 | 0.842 |
CDK3 |
0.803 | 0.269 | 1 | 0.737 |
GSK3A |
0.803 | 0.166 | 4 | 0.437 |
DYRK1A |
0.802 | 0.195 | 1 | 0.853 |
PERK |
0.802 | -0.136 | -2 | 0.786 |
TLK1 |
0.802 | -0.048 | -2 | 0.793 |
CDK14 |
0.801 | 0.247 | 1 | 0.792 |
CDC7 |
0.801 | 0.111 | 1 | 0.795 |
TAO1 |
0.800 | -0.121 | 1 | 0.694 |
DAPK1 |
0.800 | -0.016 | -3 | 0.755 |
PIM3 |
0.800 | 0.082 | -3 | 0.830 |
DYRK1B |
0.800 | 0.228 | 1 | 0.813 |
GRK1 |
0.800 | 0.175 | -2 | 0.796 |
PINK1 |
0.799 | -0.009 | 1 | 0.862 |
MLK4 |
0.799 | 0.015 | 2 | 0.659 |
PDHK4 |
0.799 | -0.125 | 1 | 0.815 |
TSSK2 |
0.799 | 0.003 | -5 | 0.815 |
MTOR |
0.798 | 0.116 | 1 | 0.786 |
CAMK2G |
0.798 | -0.034 | 2 | 0.769 |
CDK18 |
0.798 | 0.293 | 1 | 0.762 |
CDK17 |
0.798 | 0.273 | 1 | 0.720 |
CDK6 |
0.798 | 0.220 | 1 | 0.776 |
WNK4 |
0.798 | -0.109 | -2 | 0.850 |
PIM1 |
0.798 | 0.061 | -3 | 0.764 |
CDK8 |
0.797 | 0.277 | 1 | 0.820 |
HASPIN |
0.797 | -0.034 | -1 | 0.658 |
CDK16 |
0.797 | 0.276 | 1 | 0.732 |
CDKL5 |
0.797 | 0.080 | -3 | 0.763 |
NEK9 |
0.797 | -0.147 | 2 | 0.771 |
WNK1 |
0.796 | -0.007 | -2 | 0.849 |
DYRK3 |
0.796 | 0.187 | 1 | 0.871 |
GRK2 |
0.796 | 0.020 | -2 | 0.742 |
DNAPK |
0.796 | 0.061 | 1 | 0.709 |
AMPKA1 |
0.796 | -0.007 | -3 | 0.836 |
IRAK4 |
0.796 | -0.087 | 1 | 0.763 |
PKCD |
0.795 | 0.033 | 2 | 0.717 |
ERK7 |
0.795 | 0.071 | 2 | 0.493 |
SRPK1 |
0.795 | 0.182 | -3 | 0.727 |
MASTL |
0.795 | -0.193 | -2 | 0.765 |
PLK1 |
0.795 | -0.087 | -2 | 0.724 |
RIPK3 |
0.794 | -0.027 | 3 | 0.689 |
DYRK4 |
0.794 | 0.253 | 1 | 0.801 |
RIPK1 |
0.794 | -0.143 | 1 | 0.766 |
CDK13 |
0.793 | 0.245 | 1 | 0.795 |
PDHK1 |
0.793 | -0.162 | 1 | 0.804 |
DSTYK |
0.793 | 0.006 | 2 | 0.826 |
HRI |
0.793 | -0.225 | -2 | 0.790 |
CLK4 |
0.793 | 0.129 | -3 | 0.729 |
PKN3 |
0.793 | -0.034 | -3 | 0.820 |
CDK4 |
0.793 | 0.211 | 1 | 0.769 |
NEK2 |
0.793 | -0.107 | 2 | 0.750 |
SMG1 |
0.793 | 0.025 | 1 | 0.778 |
ROCK1 |
0.792 | -0.016 | -3 | 0.718 |
SRPK3 |
0.792 | 0.111 | -3 | 0.697 |
GSK3B |
0.792 | 0.060 | 4 | 0.431 |
CDK12 |
0.790 | 0.241 | 1 | 0.774 |
CDK2 |
0.790 | 0.149 | 1 | 0.825 |
MARK4 |
0.790 | -0.007 | 4 | 0.809 |
TSSK1 |
0.790 | 0.014 | -3 | 0.859 |
DCAMKL1 |
0.789 | -0.038 | -3 | 0.762 |
MST4 |
0.789 | -0.015 | 2 | 0.781 |
IRE1 |
0.788 | -0.010 | 1 | 0.776 |
CDK7 |
0.788 | 0.235 | 1 | 0.822 |
CHAK1 |
0.788 | -0.079 | 2 | 0.717 |
CRIK |
0.787 | 0.002 | -3 | 0.672 |
PIM2 |
0.787 | 0.003 | -3 | 0.703 |
TBK1 |
0.787 | -0.028 | 1 | 0.684 |
MRCKB |
0.787 | -0.001 | -3 | 0.699 |
ATM |
0.787 | 0.009 | 1 | 0.758 |
NUAK2 |
0.787 | -0.037 | -3 | 0.814 |
MRCKA |
0.786 | -0.010 | -3 | 0.718 |
NEK6 |
0.786 | 0.020 | -2 | 0.811 |
NEK3 |
0.786 | -0.187 | 1 | 0.725 |
CDK10 |
0.785 | 0.242 | 1 | 0.783 |
PKN2 |
0.785 | -0.038 | -3 | 0.811 |
P70S6KB |
0.785 | -0.022 | -3 | 0.757 |
CDK19 |
0.785 | 0.275 | 1 | 0.793 |
IKKB |
0.785 | 0.071 | -2 | 0.743 |
TGFBR2 |
0.784 | -0.025 | -2 | 0.755 |
PKCA |
0.784 | 0.030 | 2 | 0.661 |
CHK1 |
0.784 | -0.061 | -3 | 0.809 |
HUNK |
0.784 | -0.130 | 2 | 0.740 |
IKKA |
0.783 | 0.118 | -2 | 0.741 |
IRE2 |
0.783 | -0.035 | 2 | 0.679 |
SGK3 |
0.783 | 0.004 | -3 | 0.736 |
NEK7 |
0.783 | -0.109 | -3 | 0.823 |
GRK4 |
0.783 | 0.006 | -2 | 0.803 |
AMPKA2 |
0.782 | -0.016 | -3 | 0.800 |
PKCZ |
0.782 | -0.007 | 2 | 0.713 |
AKT2 |
0.782 | 0.029 | -3 | 0.647 |
CLK2 |
0.782 | 0.210 | -3 | 0.727 |
RSK2 |
0.782 | 0.073 | -3 | 0.734 |
CAMK2D |
0.781 | -0.015 | -3 | 0.815 |
PAK1 |
0.781 | -0.010 | -2 | 0.741 |
CDK9 |
0.781 | 0.198 | 1 | 0.797 |
TTBK2 |
0.780 | -0.086 | 2 | 0.662 |
IKKE |
0.780 | -0.046 | 1 | 0.687 |
ULK2 |
0.780 | -0.132 | 2 | 0.723 |
PAK2 |
0.780 | -0.058 | -2 | 0.725 |
PLK3 |
0.780 | -0.108 | 2 | 0.720 |
CLK1 |
0.779 | 0.130 | -3 | 0.697 |
DRAK1 |
0.778 | -0.132 | 1 | 0.677 |
PKCB |
0.778 | 0.011 | 2 | 0.669 |
CAMK2B |
0.777 | 0.036 | 2 | 0.761 |
P90RSK |
0.777 | 0.026 | -3 | 0.749 |
CK1D |
0.777 | 0.094 | -3 | 0.537 |
WNK3 |
0.776 | -0.241 | 1 | 0.775 |
MYLK4 |
0.776 | -0.050 | -2 | 0.722 |
DCAMKL2 |
0.776 | -0.100 | -3 | 0.769 |
SGK1 |
0.776 | 0.016 | -3 | 0.574 |
PLK2 |
0.776 | -0.023 | -3 | 0.751 |
SSTK |
0.775 | -0.021 | 4 | 0.789 |
PKCH |
0.774 | -0.054 | 2 | 0.652 |
GRK3 |
0.774 | 0.038 | -2 | 0.713 |
KIS |
0.774 | 0.308 | 1 | 0.825 |
QSK |
0.774 | -0.009 | 4 | 0.795 |
PRKD1 |
0.774 | 0.075 | -3 | 0.815 |
RSK4 |
0.774 | 0.070 | -3 | 0.726 |
NDR1 |
0.773 | -0.016 | -3 | 0.820 |
AKT1 |
0.773 | 0.014 | -3 | 0.672 |
CAMK2A |
0.773 | 0.036 | 2 | 0.754 |
MARK2 |
0.772 | -0.051 | 4 | 0.711 |
PKACG |
0.772 | 0.023 | -2 | 0.707 |
PKCG |
0.771 | -0.013 | 2 | 0.664 |
STK33 |
0.771 | -0.102 | 2 | 0.559 |
AURB |
0.771 | 0.001 | -2 | 0.617 |
IRAK1 |
0.771 | -0.273 | -1 | 0.719 |
PDHK3_TYR |
0.770 | 0.251 | 4 | 0.863 |
SRPK2 |
0.770 | 0.123 | -3 | 0.643 |
PAK3 |
0.770 | -0.066 | -2 | 0.730 |
PKCE |
0.769 | -0.003 | 2 | 0.649 |
NIM1 |
0.769 | -0.097 | 3 | 0.710 |
QIK |
0.769 | -0.129 | -3 | 0.798 |
PKG2 |
0.769 | 0.029 | -2 | 0.646 |
MELK |
0.768 | -0.101 | -3 | 0.774 |
CK1A2 |
0.768 | 0.072 | -3 | 0.532 |
MARK3 |
0.768 | -0.028 | 4 | 0.748 |
AURC |
0.767 | 0.066 | -2 | 0.625 |
MAPKAPK3 |
0.767 | -0.053 | -3 | 0.756 |
BCKDK |
0.767 | -0.099 | -1 | 0.784 |
MNK1 |
0.766 | 0.009 | -2 | 0.747 |
CAMK4 |
0.766 | -0.147 | -3 | 0.791 |
CAMK1D |
0.766 | -0.056 | -3 | 0.651 |
MSK1 |
0.766 | 0.010 | -3 | 0.723 |
NDR2 |
0.766 | 0.044 | -3 | 0.849 |
PKACB |
0.766 | 0.060 | -2 | 0.633 |
PRKD3 |
0.765 | -0.030 | -3 | 0.701 |
CK1E |
0.765 | 0.077 | -3 | 0.582 |
PRKD2 |
0.765 | 0.056 | -3 | 0.747 |
CHK2 |
0.764 | -0.065 | -3 | 0.584 |
PDHK4_TYR |
0.764 | 0.177 | 2 | 0.809 |
MARK1 |
0.764 | -0.087 | 4 | 0.765 |
AURA |
0.764 | -0.005 | -2 | 0.584 |
RSK3 |
0.764 | -0.001 | -3 | 0.733 |
PLK4 |
0.763 | -0.114 | 2 | 0.582 |
ULK1 |
0.763 | -0.154 | -3 | 0.811 |
PKCI |
0.763 | -0.064 | 2 | 0.673 |
MNK2 |
0.762 | -0.004 | -2 | 0.739 |
CK2A2 |
0.762 | 0.063 | 1 | 0.660 |
FAM20C |
0.761 | 0.166 | 2 | 0.668 |
PKCT |
0.761 | -0.067 | 2 | 0.663 |
LATS2 |
0.761 | -0.015 | -5 | 0.709 |
MAP2K4_TYR |
0.761 | 0.074 | -1 | 0.847 |
MAP2K6_TYR |
0.760 | 0.087 | -1 | 0.852 |
GCN2 |
0.760 | -0.187 | 2 | 0.739 |
CAMK1G |
0.759 | -0.088 | -3 | 0.719 |
SBK |
0.759 | 0.005 | -3 | 0.520 |
TESK1_TYR |
0.759 | 0.015 | 3 | 0.797 |
PDHK1_TYR |
0.759 | 0.081 | -1 | 0.850 |
YANK3 |
0.759 | -0.030 | 2 | 0.369 |
MSK2 |
0.758 | -0.049 | -3 | 0.720 |
RIPK2 |
0.758 | -0.320 | 1 | 0.688 |
BMPR2_TYR |
0.757 | 0.051 | -1 | 0.819 |
MAPKAPK2 |
0.757 | 0.010 | -3 | 0.709 |
YANK2 |
0.756 | -0.024 | 2 | 0.386 |
AKT3 |
0.756 | 0.038 | -3 | 0.593 |
CK2A1 |
0.756 | 0.055 | 1 | 0.638 |
SIK |
0.755 | -0.055 | -3 | 0.724 |
PKMYT1_TYR |
0.755 | -0.032 | 3 | 0.774 |
MAP2K7_TYR |
0.755 | -0.103 | 2 | 0.793 |
LIMK2_TYR |
0.753 | 0.037 | -3 | 0.872 |
TTBK1 |
0.752 | -0.146 | 2 | 0.575 |
NUAK1 |
0.751 | -0.095 | -3 | 0.759 |
PHKG1 |
0.751 | -0.104 | -3 | 0.808 |
PRKX |
0.750 | 0.092 | -3 | 0.662 |
PKACA |
0.749 | 0.020 | -2 | 0.588 |
P70S6K |
0.749 | -0.077 | -3 | 0.660 |
CAMK1A |
0.749 | -0.066 | -3 | 0.609 |
PAK6 |
0.748 | 0.044 | -2 | 0.662 |
PINK1_TYR |
0.748 | -0.193 | 1 | 0.791 |
RET |
0.746 | -0.107 | 1 | 0.762 |
BRSK1 |
0.746 | -0.080 | -3 | 0.768 |
BRSK2 |
0.745 | -0.120 | -3 | 0.788 |
EPHA6 |
0.744 | -0.060 | -1 | 0.802 |
FGR |
0.744 | -0.034 | 1 | 0.772 |
ABL2 |
0.743 | -0.038 | -1 | 0.776 |
ROS1 |
0.742 | -0.116 | 3 | 0.676 |
LIMK1_TYR |
0.742 | -0.177 | 2 | 0.790 |
CSF1R |
0.742 | -0.081 | 3 | 0.704 |
TYK2 |
0.741 | -0.196 | 1 | 0.756 |
JAK2 |
0.741 | -0.128 | 1 | 0.755 |
MST1R |
0.741 | -0.166 | 3 | 0.719 |
TXK |
0.741 | 0.022 | 1 | 0.765 |
EPHB4 |
0.741 | -0.084 | -1 | 0.780 |
FER |
0.741 | -0.095 | 1 | 0.795 |
SNRK |
0.740 | -0.246 | 2 | 0.624 |
TYRO3 |
0.739 | -0.156 | 3 | 0.702 |
MAPKAPK5 |
0.739 | -0.139 | -3 | 0.688 |
ABL1 |
0.738 | -0.063 | -1 | 0.770 |
DDR1 |
0.738 | -0.161 | 4 | 0.799 |
YES1 |
0.738 | -0.073 | -1 | 0.792 |
PKN1 |
0.738 | -0.091 | -3 | 0.675 |
KDR |
0.737 | -0.060 | 3 | 0.683 |
INSRR |
0.737 | -0.101 | 3 | 0.672 |
CK1G3 |
0.737 | 0.076 | -3 | 0.411 |
KIT |
0.736 | -0.096 | 3 | 0.711 |
LCK |
0.736 | -0.027 | -1 | 0.765 |
TNNI3K_TYR |
0.735 | -0.027 | 1 | 0.791 |
BLK |
0.735 | -0.008 | -1 | 0.758 |
FGFR2 |
0.735 | -0.110 | 3 | 0.734 |
CK1G1 |
0.734 | 0.049 | -3 | 0.579 |
PAK5 |
0.734 | -0.017 | -2 | 0.600 |
JAK3 |
0.734 | -0.142 | 1 | 0.735 |
HCK |
0.734 | -0.107 | -1 | 0.762 |
TNK2 |
0.734 | -0.081 | 3 | 0.669 |
EPHA4 |
0.733 | -0.076 | 2 | 0.716 |
SRMS |
0.733 | -0.105 | 1 | 0.773 |
MET |
0.732 | -0.072 | 3 | 0.692 |
TNK1 |
0.731 | -0.099 | 3 | 0.692 |
FLT1 |
0.731 | -0.051 | -1 | 0.787 |
ITK |
0.731 | -0.098 | -1 | 0.741 |
EPHB1 |
0.730 | -0.125 | 1 | 0.774 |
PDGFRB |
0.730 | -0.195 | 3 | 0.713 |
JAK1 |
0.730 | -0.096 | 1 | 0.703 |
FYN |
0.729 | -0.013 | -1 | 0.737 |
WEE1_TYR |
0.729 | -0.077 | -1 | 0.728 |
MERTK |
0.728 | -0.113 | 3 | 0.692 |
EPHB3 |
0.728 | -0.125 | -1 | 0.761 |
FLT3 |
0.727 | -0.198 | 3 | 0.705 |
PHKG2 |
0.727 | -0.152 | -3 | 0.752 |
FGFR3 |
0.727 | -0.104 | 3 | 0.706 |
FGFR1 |
0.727 | -0.165 | 3 | 0.684 |
ALK |
0.726 | -0.157 | 3 | 0.636 |
PTK6 |
0.725 | -0.159 | -1 | 0.707 |
EPHB2 |
0.725 | -0.130 | -1 | 0.752 |
PAK4 |
0.725 | 0.001 | -2 | 0.598 |
TEK |
0.725 | -0.171 | 3 | 0.651 |
BMX |
0.725 | -0.091 | -1 | 0.666 |
NEK10_TYR |
0.724 | -0.168 | 1 | 0.635 |
AXL |
0.724 | -0.168 | 3 | 0.689 |
TEC |
0.724 | -0.124 | -1 | 0.682 |
LTK |
0.723 | -0.165 | 3 | 0.664 |
ERBB2 |
0.722 | -0.162 | 1 | 0.704 |
EPHA7 |
0.722 | -0.110 | 2 | 0.716 |
PDGFRA |
0.721 | -0.254 | 3 | 0.709 |
NTRK1 |
0.721 | -0.207 | -1 | 0.794 |
DDR2 |
0.721 | -0.066 | 3 | 0.665 |
LYN |
0.721 | -0.108 | 3 | 0.645 |
MATK |
0.721 | -0.105 | -1 | 0.714 |
BTK |
0.720 | -0.233 | -1 | 0.716 |
NTRK3 |
0.720 | -0.122 | -1 | 0.754 |
SYK |
0.719 | 0.009 | -1 | 0.717 |
EPHA3 |
0.719 | -0.164 | 2 | 0.691 |
FRK |
0.718 | -0.146 | -1 | 0.766 |
INSR |
0.718 | -0.183 | 3 | 0.643 |
FGFR4 |
0.718 | -0.063 | -1 | 0.733 |
PTK2 |
0.718 | -0.017 | -1 | 0.722 |
EGFR |
0.718 | -0.078 | 1 | 0.605 |
FLT4 |
0.718 | -0.189 | 3 | 0.689 |
PKG1 |
0.717 | -0.045 | -2 | 0.569 |
SRC |
0.716 | -0.093 | -1 | 0.739 |
CK1G2 |
0.716 | 0.050 | -3 | 0.502 |
NTRK2 |
0.715 | -0.238 | 3 | 0.674 |
PTK2B |
0.715 | -0.123 | -1 | 0.730 |
CK1A |
0.714 | 0.081 | -3 | 0.454 |
EPHA5 |
0.714 | -0.126 | 2 | 0.704 |
CSK |
0.714 | -0.147 | 2 | 0.721 |
EPHA1 |
0.713 | -0.196 | 3 | 0.672 |
EPHA8 |
0.713 | -0.118 | -1 | 0.731 |
IGF1R |
0.707 | -0.151 | 3 | 0.594 |
ERBB4 |
0.705 | -0.079 | 1 | 0.626 |
ZAP70 |
0.705 | 0.007 | -1 | 0.659 |
EPHA2 |
0.704 | -0.113 | -1 | 0.705 |
MUSK |
0.695 | -0.218 | 1 | 0.596 |
FES |
0.689 | -0.181 | -1 | 0.656 |