MAPKAPK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A4FU28 S140 Sugiyama CTAGE9 AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
O00115 S70 Sugiyama DNASE2 DNASE2A DNL2 QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O00170 S159 Sugiyama AIP XAP2 DALQQNPQPLIFHMEMLKVEsPGtYQQDPWAMTDEEKAKAV
O00232 S335 Sugiyama PSMD12 MRWSTLVEDYGMELRKGsLEsPAtDVFGsTEEGEKRWKDLK
O00273 S28 Sugiyama DFFA DFF1 DFF45 H13 GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00418 S377 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EEF2K CGsPQVRTLsGSRPPLLRPLsENSGDENMSDVTFDsLPSsP
O14497 S363 Sugiyama ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1 AAAAAAASGGAQQRsHHAPMsPGssGGGGQPLARtPQPssP
O14545 T323 Sugiyama TRAFD1 FLN29 ELLIDHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQ
O14639 S452 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14745 S280 Sugiyama NHERF1 NHERF SLC9A3R1 tNGEIQKENsREALAEAALEsPRPALVRsAssDtsEELNsQ
O14745 S291 Sugiyama NHERF1 NHERF SLC9A3R1 EALAEAALEsPRPALVRsAssDtsEELNsQDsPPKQDSTAP
O14910 S130 Sugiyama LIN7A MALS1 VELI1 ELPKTDEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLK
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 S995 Sugiyama PPP1R12A MBS MYPT1 ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15226 S618 Sugiyama NKRF ITBA4 NRF VNKIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQ
O15511 S77 GPS6|SIGNOR|iPTMNet|EPSD|PSP ARPC5 ARC16 AALKNPPINTKSQAVKDRAGsIVLKVLISFKANDIEKAVQS
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852 T65 Sugiyama CALU FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O43865 S66 Sugiyama AHCYL1 DCAL IRBIT XPVKONA DDMQEFTKFPTKTGRRSLSRsIsQSsTDsySsAASYTDssD
O60333 S649 Sugiyama KIF1B KIAA0591 KIAA1448 NHVFRFNHPEQARAEREKtPsAEtPsEPVDWTFAQRELLEK
O60333 T652 Sugiyama KIF1B KIAA0591 KIAA1448 FRFNHPEQARAEREKtPsAEtPsEPVDWTFAQRELLEKQGI
O60343 S485 Sugiyama TBC1D4 AS160 KIAA0603 CERIEGLYPPRAKLVIQRHLssLtDNEQADIFERVQKMKPV
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60749 S365 Sugiyama SNX2 TRG9 AKSAAMLGNsEDHTALSRALsQLAEVEEKIDQLHQEQAFAD
O75179 S2042 Sugiyama ANKRD17 GTAR KIAA0697 TAPTNATYPMPTAKEHyPVssPssPsPPAQPGGVsRNsPLD
O75179 S2045 Sugiyama ANKRD17 GTAR KIAA0697 TNATYPMPTAKEHyPVssPssPsPPAQPGGVsRNsPLDCGs
O75391 S158 Sugiyama SPAG7 LKELAQRQEEEAAQQGPVVVsPAsDyKDKYSHLIGKGAAKD
O75534 S584 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP
O75925 S522 SIGNOR|EPSD|PSP PIAS1 DDXBP1 AsPVsRtPsLPAVDtsYINTsLIQDYRHPFHMTPMPYDLQG
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95155 S79 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 NMtPAtsPIGASGVAHRsQssEGVssLsssPsNsLEtQsQs
O95197 T318 Sugiyama RTN3 ASYIP NSPL2 RNKEAGRYPMSALLSRQFsHtNAALEEVSRCVNDMHNFTNE
O95359 S2317 Sugiyama TACC2 MPLRRPKMKKtPEKLDNtPAsPPRsPAEPNDIPIAKGTYTF
O95359 S2321 Sugiyama TACC2 RPKMKKtPEKLDNtPAsPPRsPAEPNDIPIAKGTYTFDIDK
O95425 S221 Sugiyama SVIL NIENQRRGQELsATRQAHDLsPAAEsssTFsFSGRDssFtE
O95453 S557 GPS6|SIGNOR|EPSD|PSP|Sugiyama PARN DAN KRLNPQCIPYTLQNHYYRNNsFtAPstVGKRNLsPsQEEAG
O95816 S20 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP BAG2 _MAQAKINAKANEGRFCRsssMADRsSRLLEsLDQLELRVE
P00367 T409 Sugiyama GLUD1 GLUD TKSNAPRVKAKIIAEGANGPttPEADKIFLERNIMVIPDLY
P00367 T410 Sugiyama GLUD1 GLUD KSNAPRVKAKIIAEGANGPttPEADKIFLERNIMVIPDLYL
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P03372 S118 EPSD ESR1 ESR NR3A1 PPLNsVsPsPLMLLHPPPQLsPFLQPHGQQVPYYLENEPSG
P04075 S176 Sugiyama ALDOA ALDA EHtPsALAIMENANVLARyAsICQQNGIVPIVEPEILPDGD
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 S312 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04637 S20 EPSD|PSP TP53 P53 _MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM
P04792 S15 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama HSPB1 HSP27 HSP28 ______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792 S78 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05023 S519 Sugiyama ATP1A1 sEPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQ
P05023 S520 Sugiyama ATP1A1 EPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQN
P05387 S86 Sugiyama RPLP2 D11S2243E RPP2 PAGGAVAVsAAPGsAAPAAGsAPAAAEEKKDEKKEEsEEsD
P05455 S92 Sugiyama SSB LSKSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRs
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05783 S53 EPSD|PSP KRT18 CYK18 PIG46 AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P05997 S1277 Sugiyama COL5A2 APDDKNKTDPGVHATLKSLSsQIETMRSPDGSKKHPARTCD
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06744 S455 Sugiyama GPI ALMRGKSTEEARKELQAAGKsPEDLERLLPHKVFEGNRPTN
P07101 S19 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TH TYH __MPTPDATTPQAKGFRRAVsELDAKQAEAIMVRGQGAPGP
P07101 S40 GPS6|SIGNOR|ELM|iPTMNet|EPSD TH TYH ELDAKQAEAIMVRGQGAPGPsLTGsPWPGTAAPAASYTPTP
P07101 S71 EPSD|PSP TH TYH APAASYTPTPRsPRFIGRRQsLIEDARKEREAAVAAAAAAV
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07339 S37 Sugiyama CTSD CPSD PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 Y827 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EIGQNIssNssAsILESKsLyDEVAAQGEVVRKLKAEKSPK
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08670 S39 GPS6|ELM|iPTMNet|EPSD VIM GtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyAssPGG
P08670 S51 GPS6|ELM|iPTMNet|EPSD VIM VttsTRtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLR
P08670 S56 GPS6|ELM|iPTMNet|EPSD VIM RtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLRssVPG
P08670 S83 GPS6|ELM|iPTMNet|EPSD VIM tRssAVRLRssVPGVRLLQDsVDFsLADAINTEFKNTRTNE
P08865 T97 Sugiyama RPSA LAMBR LAMR1 IssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQAAFR
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09917 S272 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ALOX5 LOG5 LPEKLPVtTEMVECSLERQLsLEQEVQQGNIFIVDFELLDG
P09972 S176 Sugiyama ALDOC ALDC ERTPSALAILENANVLARyAsICQQNGIVPIVEPEILPDGD
P0CG41 S140 Sugiyama CTAGE8 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P0DPH7 S54 Sugiyama TUBA3C TUBA2 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P0DPH7 T56 Sugiyama TUBA3C TUBA2 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
P10809 T117 Sugiyama HSPD1 HSP60 LVQDVANNtNEEAGDGtttAtVLARSIAKEGFEKISKGANP
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T37 Sugiyama HSPA8 HSC70 HSP73 HSPA10 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11388 S1247 Sugiyama TOP2A TOP2 MKAEAEKKNKKKIKNENtEGsPQEDGVELEGLKQRLEKKQK
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P11532 S3624 Sugiyama DMD AKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEED
P11831 S103 SIGNOR|iPTMNet|EPSD|PSP SRF sEsGEEEELGAERRGLKRsLsEMEIGMVVGGPEASAAATGG
P11831 S85 GPS6|ELM|iPTMNet|EPSD SRF ATTPAPTAGALYsGsEGDsEsGEEEELGAERRGLKRsLsEM
P12270 S2155 Sugiyama TPR PstPtLVVPHRtDGFAEAIHsPQVAGVPRFRFGPPEDMPQT
P12277 T35 Sugiyama CKB CKBB PAEDEFPDLSAHNNHMAKVLtPELyAELRAKSTPSGFTLDD
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 T735 Sugiyama EEF2 EF2 HRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCPEQV
P13797 S339 Sugiyama PLS3 PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14866 S101 Sugiyama HNRNPL HNRPL P/OKcl.14 GAAGGGGGGENyDDPHKtPAsPVVHIRGLIDGVVEADLVEA
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15336 S62 Sugiyama ATF2 CREB2 CREBP1 LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV
P15336 T69 Sugiyama ATF2 CREB2 CREBP1 HEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELA
P15336 T71 Sugiyama ATF2 CREB2 CREBP1 MtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELAsP
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16220 S119 SIGNOR|PSP CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16949 S38 Sugiyama STMN1 C1orf215 LAP18 OP18 QAFELILsPRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAE
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17302 S255 PSP GJA1 GJAL GVKDRVKGKSDPyHATsGALsPAKDCGsQKyAyFNGCssPt
P17302 S279 PSP GJA1 GJAL DCGsQKyAyFNGCssPtAPLsPMsPPGyKLVTGDRNNssCR
P17302 S282 PSP GJA1 GJAL sQKyAyFNGCssPtAPLsPMsPPGyKLVTGDRNNssCRNYN
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17544 T42 Sugiyama ATF7 ATFA DHLAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCE
P17544 T51 Sugiyama ATF7 ATFA HEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEVGLFNELA
P17544 T53 Sugiyama ATF7 ATFA MTLKFGPARtDsVIIADQtPtPtRFLKNCEEVGLFNELASS
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17844 S198 EPSD|PSP DDX5 G17P1 HELR HLR1 ELAQQVQQVAAEyCRACRLKsTCIyGGAPKGPQIRDLERGV
P18615 S115 EPSD|PSP|Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615 S138 Sugiyama NELFE RD RDBP DDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEGPGA
P18615 S251 EPSD|PSP NELFE RD RDBP DRDRERDRDRDREGPFRRsDsFPERRAPRKGNTLyVyGEDM
P18615 S51 EPSD|PSP NELFE RD RDBP ALKKQSSSSTTSQGGVKRsLsEQPVMDTATATEQAKQLVKS
P18669 S31 Sugiyama PGAM1 PGAMA CDABP0006 HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P18859 S57 Sugiyama ATP5PF ATP5A ATP5J ATPM DPIQKLFVDKIREYKSKRQTsGGPVDAssEyQQELERELFK
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P21333 S2319 Sugiyama FLNA FLN FLN1 VQEPGDyEVsVKFNEEHIPDsPFVVPVAsPsGDARRLtVss
P21333 S2327 Sugiyama FLNA FLN FLN1 VsVKFNEEHIPDsPFVVPVAsPsGDARRLtVssLQEsGLKV
P21333 S2329 Sugiyama FLNA FLN FLN1 VKFNEEHIPDsPFVVPVAsPsGDARRLtVssLQEsGLKVNQ
P22059 S240 Sugiyama OSBP OSBP1 DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23396 T221 Sugiyama RPS3 OK/SW-cl.26 KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P23588 Y609 Sugiyama EIF4B sASKyAALsVDGEDENEGEDyAE__________________
P25054 S1389 Sugiyama APC DP2.5 PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25054 S2129 Sugiyama APC DP2.5 NSIVSSLHQAAAAACLsRQAssDSDSILSLKsGIsLGsPFH
P25786 S110 Sugiyama PSMA1 HC2 NU PROS30 PSC2 QECLDSRFVFDRPLPVsRLVsLIGsKTQIPTQRYGRRPYGV
P25786 S14 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26447 S60 Sugiyama S100A4 CAPL MTS1 RELPSFLGKRTDEAAFQKLMsNLDSNRDNEVDFQEYCVFLS
P26651 S113 SIGNOR ZFP36 G0S24 NUP475 RNF162A TIS11A TTP sPtATSTtPSRYKTELCRTFsESGRCRYGAKCQFAHGLGEL
P26651 S184 SIGNOR ZFP36 G0S24 NUP475 RNF162A TIS11A TTP FIHNPSEDLAAPGHPPVLRQsIsFsGLPSGRRTsPPPPGLA
P26651 S186 GPS6|SIGNOR|EPSD ZFP36 G0S24 NUP475 RNF162A TIS11A TTP HNPSEDLAAPGHPPVLRQsIsFsGLPSGRRTsPPPPGLAGP
P26651 S52 EPSD ZFP36 G0S24 NUP475 RNF162A TIS11A TTP WGSSGPWSLSPSDSSPSGVTsRLPGRSTsLVEGRsCGWVPP
P26651 S60 GPS6|SIGNOR|EPSD ZFP36 G0S24 NUP475 RNF162A TIS11A TTP LSPSDSSPSGVTsRLPGRSTsLVEGRsCGWVPPPPGFAPLA
P26651 S66 SIGNOR ZFP36 G0S24 NUP475 RNF162A TIS11A TTP SPSGVTsRLPGRSTsLVEGRsCGWVPPPPGFAPLAPRLGPE
P27348 S63 Sugiyama YWHAQ LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27815 S152 SIGNOR PDE4A DPDE2 VLHAGAATSQRREsFLYRSDsDYDMsPKTMSRNssVtsEAH
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29966 S27 Sugiyama MARCKS MACS PRKCSL KTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAsP
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30101 S443 Sugiyama PDIA3 ERP57 ERP60 GRP58 LsKDPNIVIAKMDAtANDVPsPyEVRGFPtIyFsPANKKLN
P30305 S169 GPS6|EPSD|PSP CDC25B CDC25HU2 FQsMPVRLLGHsPVLRNItNsQAPDGRRKsEAGSGAAssSG
P30305 S323 GPS6|ELM|iPTMNet|EPSD|PSP CDC25B CDC25HU2 KEEEKDLVMYSKCQRLFRsPsMPCSVIRPILKRLERPQDRD
P30305 S353 GPS6|EPSD|PSP CDC25B CDC25HU2 LKRLERPQDRDTPVQNKRRRsVtPPEEQQEAEEPKARVLRs
P30305 S375 GPS6|EPSD|PSP CDC25B CDC25HU2 tPPEEQQEAEEPKARVLRsKsLCHDEIENLLDSDHRELIGD
P30307 S216 EPSD|PSP CDC25C EFsLKDQEAKVSRsGLYRsPsMPENLNRPRLKQVEKFKDNt
P31749 S473 EPSD|PSP AKT1 PKB RAC DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P31943 S23 Sugiyama HNRNPH1 HNRPH HNRPH1 LGTEGGEGFVVKVRGLPWsCsADEVQRFFSDCKIQNGAQGI
P31946 S132 Sugiyama YWHAB TQPESKVFyLKMKGDYFRyLsEVAsGDNKQTtVsNsQQAyQ
P31946 S65 Sugiyama YWHAB LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33241 S204 GPS6|SIGNOR|ELM|iPTMNet|EPSD LSP1 WP34 tIEQssPPLsPttKLIDRtEsLNRsIEKSNSVKKsQPDLPI
P33241 S252 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP LSP1 WP34 EQyTQAIETAGRTPKLARQAsIELPSMAVASTKSRWETGEV
P33527 S915 Sugiyama ABCC1 MRP MRP1 QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P34931 S241 SIGNOR|PSP HSPA1L VKAtAGDtHLGGEDFDNRLVsHFVEEFKRKHKKDISQNKRA
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T39 Sugiyama HSPA1L CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35900 S13 GPS6|SIGNOR|EPSD|PSP KRT20 ________MDFSRRSFHRSLsSSLQAPVVSTVGMQRLGTTP
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 T86 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P40189 S782 GPS6 IL6ST VVHSGyRHQVPSVQVFSRsEstQPLLDSEERPEDLQLVDHV
P40222 S514 Sugiyama TXLNA TXLN GsLtDsGPERRPEGPGAQAPssPRVtEAPCyPGAPSTEASG
P40337 S68 Sugiyama VHL LGAEEEMEAGRPRPVLRSVNsREPsQVIFCNRsPRVVLPVW
P41091 T109 Sugiyama EIF2S3 EIF2G YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43686 S117 Sugiyama PSMC4 MIP224 TBP7 DQNTAIVGSTTGSNYYVRILsTIDRELLKPNASVALHKHSN
P46013 S308 Sugiyama MKI67 VSRKSRPKsGGsGHAVAEPAsPEQELDQNKGKGRDVEsVQt
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937 T110 Sugiyama YAP1 YAP65 KLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPA
P46937 T119 Sugiyama YAP1 YAP65 PEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQLGAVsP
P47756 S207 Sugiyama CAPZB MNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMENKIRst
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49137 S339 Sugiyama MAPKAPK2 FMNHPWIMQSTKVPQtPLHtsRVLKEDKERWEDVKEEMtsA
P49137 S358 Sugiyama MAPKAPK2 tsRVLKEDKERWEDVKEEMtsALATMRVDYEQIKIKKIEDA
P49137 T195 Sugiyama MAPKAPK2 QYLHSINIAHRDVKPENLLYtSKRPNAILKLtDFGFAKEtt
P49137 T226 Sugiyama MAPKAPK2 tDFGFAKEttsHNsLttPCytPyyVAPEVLGPEKYDKSCDM
P49137 T334 Sugiyama MAPKAPK2 MTItEFMNHPWIMQSTKVPQtPLHtsRVLKEDKERWEDVKE
P49137 T338 GPS6|ELM|iPTMNet|EPSD|PSP|Sugiyama MAPKAPK2 EFMNHPWIMQSTKVPQtPLHtsRVLKEDKERWEDVKEEMts
P49137 T357 Sugiyama MAPKAPK2 HtsRVLKEDKERWEDVKEEMtsALATMRVDYEQIKIKKIED
P49137 Y225 Sugiyama MAPKAPK2 LtDFGFAKEttsHNsLttPCytPyyVAPEVLGPEKYDKSCD
P49137 Y228 Sugiyama MAPKAPK2 FGFAKEttsHNsLttPCytPyyVAPEVLGPEKYDKSCDMWS
P49137 Y229 Sugiyama MAPKAPK2 GFAKEttsHNsLttPCytPyyVAPEVLGPEKYDKSCDMWSL
P49448 T409 Sugiyama GLUD2 GLUDP1 TKSNAPRVKAKIIAEGANGPttPEADKIFLERNILVIPDLY
P49448 T410 Sugiyama GLUD2 GLUDP1 KSNAPRVKAKIIAEGANGPttPEADKIFLERNILVIPDLYL
P49588 S249 Sugiyama AARS1 AARS ILKPLPKKsIDtGMGLERLVsVLQNKMSNYDTDLFVPYFEA
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49815 S1254 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TSC2 TSC4 ALMAAERFKEHRDTALYKsLsVPAAsTAKPPPLPRSNTVAS
P50502 S181 Sugiyama ST13 AAG2 FAM10A1 HIP SNC6 LQKPNAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
P50549 S191 SIGNOR|iPTMNet|EPSD ETV1 ER81 PSQSIPDSSYPMDHRFRRQLsEPCNSFPPLPTMPREGRPMY
P50549 S216 SIGNOR|iPTMNet|EPSD ETV1 ER81 SFPPLPTMPREGRPMYQRQMsEPNIPFPPQGFKQEYHDPVY
P50552 T335 Sugiyama VASP tTLPRMKssssVttsEtQPCtPsSSDySDLQRVKQELLEEV
P50991 S444 Sugiyama CCT4 CCTD SRB GGGAPEIELALRLTEYSRTLsGMEsyCVRAFADAMEVIPST
P51812 S386 GPS6|EPSD RPS6KA3 ISPK1 MAPKAPK1B RSK2 PKDsPGIPPsANAHQLFRGFsFVAItsDDESQAMQTVGVHS
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52948 S623 Sugiyama NUP98 ADAR2 KNLNNsNLFsPVNRDsENLAsPsEyPENGERFsFLSKPVDE
P53350 S326 SIGNOR|EPSD|PSP PLK1 PLK TSGYIPARLPITCLTIPPRFsIAPssLDPsNRKPLtVLNKG
P53350 S383 EPSD|PSP PLK1 PLK VRETGEVVDCHLsDMLQQLHsVNAsKPSERGLVRQEEAEDP
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53667 S323 GPS6|SIGNOR|EPSD|PSP LIMK1 LIMK PGAGsLGsPAsQRKDLGRSEsLRVVCRPHRIFRPSDLIHGE
P53992 S378 Sugiyama SEC24C KIAA0079 TTNFLVKDQGNASPRYIRCTsyNIPCTSDMAKQAQVPLAAV
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T38 Sugiyama HSPA2 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P55010 S10 Sugiyama EIF5 ___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P55036 S115 Sugiyama PSMD4 MCB1 LALKHRQGKNHKMRIIAFVGsPVEDNEKDLVKLAKRLKKEK
P55196 S1698 Sugiyama AFDN AF6 MLLT4 PEAPGLCRPPLPRDyEPPsPsPAPGAPPPPPQRNASYLKtQ
P55196 S424 Sugiyama AFDN AF6 MLLT4 HTYEDGSDSRDKPKLYRLQLsVtEVGTEKLDDNSIQLFGPG
P57772 S28 Sugiyama EEFSEC SELB VNVGVLGHIDSGKTALARALsTTASTAAFDKQPQSRERGIT
P60174 Y48 Sugiyama TPI1 TPI tLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQNCy
P60228 S442 Sugiyama EIF3E EIF3S6 INT6 IEKKLNQNSRSEAPNWAtQDsGFy_________________
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61758 T45 Sugiyama VBP1 PFDN3 IPEAVFVEDVDSFMKQPGNEtADtVLKKLDEQYQKYKFMEL
P61978 S77 Sugiyama HNRNPK HNRPK VIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIETI
P61981 S64 Sugiyama YWHAG LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P63010 S531 Sugiyama AP2B1 ADTB2 CLAPB1 TQDSDNPDLRDRGyIyWRLLsTDPVTAKEVVLSEKPLISEE
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 S58 GPS6|SIGNOR|iPTMNet|EPSD|PSP YWHAZ NEERNLLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQM
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68363 S54 Sugiyama TUBA1B GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P68363 T56 Sugiyama TUBA1B MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P85037 S420 Sugiyama FOXK1 MNF RGVSCFRtPFGPLssRsAPAsPtHPGLMsPRsGGLQtPECL
P85037 S428 Sugiyama FOXK1 MNF PFGPLssRsAPAsPtHPGLMsPRsGGLQtPECLsREGsPIP
P98082 S723 Sugiyama DAB2 DOC2 DANQLLNKINEPPKPAPRQVsLPVTKstDNAFENPFFKDsF
Q00610 S146 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q00613 S121 GPS6|ELM|iPTMNet|EPSD|PSP HSF1 HSTF1 HPCFLRGQEQLLENIKRKVtsVSTLKSEDIKIRQDSVTKLL
Q00987 S157 EPSD|PSP MDM2 DLVQELQEEKPSSSHLVSRPstSSRRRAIsEtEENsDELsG
Q00987 S166 SIGNOR|EPSD|PSP MDM2 KPSSSHLVSRPstSSRRRAIsEtEENsDELsGERQRKRHKs
Q01105 S133 Sugiyama SET DEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLS
Q01814 S1234 Sugiyama ATP2B2 PMCA2 DSGINLTTDtsKSATSSsPGsPIHSLEtsL___________
Q01844 T422 Sugiyama EWSR1 EWS LDKETGKPKGDATVSyEDPPtAKAAVEWFDGKDFQGSKLKV
Q01860 S111 GPS6|PSP POU5F1 OCT3 OCT4 OTF3 ETsQPEGEAGVGVESNSDGAsPEPCTVtPGAVKLEKEKLEQ
Q01860 S93 PSP POU5F1 OCT3 OCT4 OTF3 MAYCGPQVGVGLVPQGGLETsQPEGEAGVGVESNSDGAsPE
Q02952 T285 Sugiyama AKAP12 AKAP250 CKEEGEEKQEKEPSKsAEsPtsPVtsETGstFKKFFTQGWA
Q04637 S1231 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI tEDRDRGRDAVKREAALPPVsPLKAALsEEELEKKsKAIIE
Q04721 S838 Sugiyama NOTCH2 TCHCVLPYTGKNCQTVLAPCsPNPCENAAVCKESPNFESYT
Q04917 S64 Sugiyama YWHAH YWHA1 LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q05397 S677 Sugiyama PTK2 FAK FAK1 KCWAYDPSRRPRFTELKAQLsTILEEEKAQQEERMRMEsRR
Q06124 S140 Sugiyama PTPN11 PTP2C SHPTP2 KEAEKLLTEKGKHGsFLVREsQsHPGDFVLSVRTGDDKGES
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q06830 T156 Sugiyama PRDX1 PAGA PAGB TDPX2 KGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEVCPAG
Q07352 S203 GPS6|SIGNOR|EPSD|PSP ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B RALAGARDLSADRPRLQHSFsFAGFPSAAATAAATGLLDSP
Q07352 S54 GPS6|SIGNOR|EPSD|PSP ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B CLLDRKAVGtPAGGGFPRRHsVTLPSSKFHQNQLLSsLKGE
Q07352 S92 GPS6|SIGNOR|EPSD|PSP ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B KGEPAPALSSRDsRFRDRsFsEGGERLLPTQKQPGGGQVNS
Q07817 S62 EPSD|PSP BCL2L1 BCL2L BCLX ESEMEtPsAINGNPSWHLADsPAVNGATGHSSSLDAREVIP
Q07866 S460 Sugiyama KLC1 KLC KNS2 QKDGTsFGEyGGWyKACKVDsPtVTTtLKNLGALyRRQGKF
Q07960 S51 Sugiyama ARHGAP1 CDC42GAP RHOGAP1 KNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARHQ
Q08AD1 S1313 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q08AD1 S464 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q08J23 S743 Sugiyama NSUN2 SAKI TRM4 AstGQPDNDVtEGQRAGEPNsPDAEEANsPDVtAGCDPAGV
Q08J23 S751 Sugiyama NSUN2 SAKI TRM4 DVtEGQRAGEPNsPDAEEANsPDVtAGCDPAGVHPPR____
Q09666 S41 Sugiyama AHNAK PM227 HGLTIAQRDDGVFVQEVtQNsPAARTGVVKEGDQIVGATIy
Q09666 T3716 Sugiyama AHNAK PM227 VEGDLKGPEVDIKGPKVDIDtPDINIEGsEGKFKGPKFKIP
Q10567 S531 Sugiyama AP1B1 ADTB1 BAM22 CLAPB2 TQDSDNPDLRDRGyIyWRLLsTDPVAAKEVVLAEKPLISEE
Q12931 S568 Sugiyama TRAP1 HSP75 HSPC5 ISVETDIVVDHYKEEKFEDRsPAAECLSEKETEELMAWMRN
Q12965 S1002 Sugiyama MYO1E MYO1C RSNQKSLyTsMARPPLPRQQstssDRVsQtPEsLDFLKVPD
Q13137 S238 Sugiyama CALCOCO2 NDP52 KMSSENEKMGIRVDQLQAQLsTQEKEMEKLVQGDQDKTEQL
Q13151 S84 GPS6|SIGNOR|EPSD|PSP HNRNPA0 HNRPA0 AMAAsPHAVDGNTVELKRAVsREDsARPGAHAKVKKLFVGG
Q13206 S829 Sugiyama DDX10 sEDMENKISDTKKKQGMKKRsNsEVEDVGPTsHNRKKARWD
Q13206 S831 Sugiyama DDX10 DMENKISDTKKKQGMKKRsNsEVEDVGPTsHNRKKARWDTL
Q13263 S473 EPSD|PSP|Sugiyama TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13464 S742 Sugiyama ROCK1 EEREAREKAENRVVQIEKQCsMLDVDLKQSQQKLEHLTGNK
Q13546 S320 EPSD|PSP RIPK1 RIP RIP1 DVKSLKKEYSNENAVVKRMQsLQLDCVAVPssRsNsAtEQP
Q13573 S224 Sugiyama SNW1 SKIIP SKIP KDPMEPPRFKINKKIPRGPPsPPAPVMHsPsRKMTVKEQQE
Q13596 S368 Sugiyama SNX1 AKSLAMLGSSEDNTALSRALsQLAEVEEKIEQLHQEQANND
Q14103 S190 Sugiyama HNRNPD AUF1 HNRPD KRAKAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVES
Q14103 T193 Sugiyama HNRNPD AUF1 HNRPD KAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVESIEL
Q14126 S551 Sugiyama DSG2 CDHF5 FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14126 S553 Sugiyama DSG2 CDHF5 VIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFLIS
Q14126 T552 Sugiyama DSG2 CDHF5 SVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFLI
Q14134 S550 SIGNOR|EPSD|PSP TRIM29 ATDC LPVVQGSSSFsLKGyPSLMRsQsPKAQPQTWKSGKQTMLSH
Q14134 S552 EPSD|PSP TRIM29 ATDC VVQGSSSFsLKGyPSLMRsQsPKAQPQTWKSGKQTMLSHYR
Q14160 S504 Sugiyama SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL MKRSIEGRRsEACPCQPDsGsPLPAEEEKRLsAESGLSEDS
Q14204 S4162 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 GRIFVFEPPPGVKANMLRTFssIPVSRICKSPNERARLYFL
Q14247 S282 Sugiyama CTTN EMS1 QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14247 S405 Sugiyama CTTN EMS1 EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14247 Y421 Sugiyama CTTN EMS1 tPPVsPAPQPtEERLPssPVyEDAAsFKAELsyRGPVsGtE
Q14457 S90 EPSD|PSP BECN1 GT197 IETPRQDGVSRRFIPPARMMsTEsANsFTLIGEASDGGtME
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14676 T447 Sugiyama MDC1 KIAA0170 NFBD1 WNRDAEEDMPQRVVLLQRsQtttERDsDtDVEEEELPVENR
Q14980 S1757 Sugiyama NUMA1 NMP22 NUMA ITSKLPRtQPDGtsVPGEPAsPIsQRLPPKVEsLEsLyFtP
Q15003 S78 Sugiyama NCAPH BRRN BRRN1 CAPH KIAA0074 NDDEKERLQRRRsRVFDLQFstDsPRLLAsPsSRsIDIsAT
Q15084 S389 Sugiyama PDIA6 ERP5 P5 TXNDC7 FALLKGsFsEQGINEFLRELsFGRGstAPVGGGAFPtIVER
Q15181 S272 Sugiyama PPA1 IOPPP PP FKCDPDAARAIVDALPPPCEsACTVPTDVDKWFHHQKN___
Q15276 S407 Sugiyama RABEP1 RAB5EP RABPT5 RABPT5A GDPFSKSDNDMFKDGLRRAQstDsLGtsGsLQSKALGYNYK
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15365 S190 Sugiyama PCBP1 LsQsPQGRVMtIPyQPMPAssPVICAGGQDRCsDAAGYPHA
Q15599 S43 Sugiyama NHERF2 SLC9A3R2 FHLHGEKGRRGQFIRRVEPGsPAEAAALRAGDRLVEVNGVN
Q15759 S243 Sugiyama MAPK11 PRKM11 SAPK2 SAPK2B FPGSDYIDQLKRIMEVVGtPsPEVLAKISSEHARTYIQsLP
Q15759 T180 Sugiyama MAPK11 PRKM11 SAPK2 SAPK2B EDCELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHY
Q15759 T241 Sugiyama MAPK11 PRKM11 SAPK2 SAPK2B ALFPGSDYIDQLKRIMEVVGtPsPEVLAKISSEHARTYIQs
Q15759 Y182 Sugiyama MAPK11 PRKM11 SAPK2 SAPK2B CELRILDFGLARQADEEMtGyVAtRWYRAPEIMLNWMHYNQ
Q15785 S45 Sugiyama TOMM34 URCC3 yAEASALyGRALRVLQAQGssDPEEEsVLysNRAACHLKDG
Q15788 S1185 EPSD NCOA1 BHLHE74 SRC1 QQFPYPPNYGTNPGtPPASTsPFSQLAANPEASLANRNSMV
Q15788 T1179 EPSD NCOA1 BHLHE74 SRC1 LPQGAPQQFPYPPNYGTNPGtPPASTsPFSQLAANPEASLA
Q16204 S244 Sugiyama CCDC6 D10S170 TST1 LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16204 S323 Sugiyama CCDC6 D10S170 TST1 RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16630 T157 Sugiyama CPSF6 CFIM68 SKKLMDLLPKRELHGQNPVVtPCNKQFLsQFEMQSRKTTQS
Q16644 S337 Sugiyama MAPKAPK3 tARVLQEDKDHWDEVKEEMTsALATMRVDYDQVKIKDLKTS
Q16644 T175 Sugiyama MAPKAPK3 QFLHSHNIAHRDVKPENLLYtSKEKDAVLKLTDFGFAKEtt
Q16875 S461 EPSD|PSP PFKFB3 THRERSEDAKKGPNPLMRRNsVtPLAsPEPtKKPRINsFEE
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3MII6 S506 Sugiyama TBC1D25 OATL1 DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q53EL6 S94 Sugiyama PDCD4 H731 GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q5JTD0 S545 Sugiyama TJAP1 PILT TJP4 ssRPQRsPKRMGVHHLHRKDsLtQAQEQGNLLN________
Q5T4S7 S178 Sugiyama UBR4 KIAA0462 KIAA1307 RBAF600 AKLPQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLT
Q5T4S7 S181 Sugiyama UBR4 KIAA0462 KIAA1307 RBAF600 PQTVKTLSDVEDQKELAsPVsPELRQKEVQMNFLNQLTSVF
Q66K14 S1238 Sugiyama TBC1D9B KIAA0676 EKRVDIGLKIKDQKKVERQFstAsDHEQPGVsG________
Q6JBY9 S179 GPS6|SIGNOR|EPSD|PSP RCSD1 CAPZIP VRTRGSIKRRPPSRRFRRsQsDCGELGDFRAVESSQQNGAK
Q6JBY9 S244 GPS6|SIGNOR|EPSD|PSP RCSD1 CAPZIP AGEGVRTLGPAEKPPLRRSPsRTEKQEEDRATEEAKNGEKA
Q6PEY2 S54 Sugiyama TUBA3E GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6PEY2 T56 Sugiyama TUBA3E MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
Q6PKG0 S774 Sugiyama LARP1 KIAA0731 LARP LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q6UVK1 S1857 Sugiyama CSPG4 MCSP ASVPLRLTRGSRAPISRAQLsVVDPDSAPGEIEyEVQRAPH
Q71U36 S54 Sugiyama TUBA1A TUBA3 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q71U36 T56 Sugiyama TUBA1A TUBA3 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7L2J0 S216 Sugiyama MEPCE BCDIN3 NLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDIt
Q7L2J0 T213 Sugiyama MEPCE BCDIN3 DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7L5N7 S34 SIGNOR LPCAT2 AGPAT11 AYTL1 VPGAGVGNVGLRPPMVPRQAsFFPPPVPNPFVQQTQIGSAR
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z417 S692 Sugiyama NUFIP2 KIAA1321 PIG1 IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q86UF2 S140 Sugiyama CTAGE6 CTAGE6P AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86V81 Y250 Sugiyama ALYREF ALY BEF THOC4 AGRNSKQQLsAEELDAQLDAyNARMDts_____________
Q86YP4 S100 Sugiyama GATAD2A DGPVDMRTSHSDMKSERRPPsPDVIVLsDNEQPssPRVNGL
Q86YP4 S114 Sugiyama GATAD2A SERRPPsPDVIVLsDNEQPssPRVNGLttVALKETSTEALM
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IX94 S140 Sugiyama CTAGE4 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N556 S264 Sugiyama AFAP1 AFAP IKEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssD
Q8N556 S668 Sugiyama AFAP1 AFAP AGGVTLGLAIEPKsGtssPQsPVFRHRtLENsPIssCDtsD
Q8N5C8 S506 GPS6|EPSD|PSP TAB3 MAP3K7IP3 ISVIPGsGGEKGSHKYQRssssGsDDyAyTQALLLHQRARM
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ5 S612 Sugiyama COLGALT1 GLT25D1 PSEC0241 QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBJ7 S281 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 ADGsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPPGEL
Q8ND56 S300 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A GRFGIRRDGPMKFEKDFDFEsANAQFNKEEIDREFHNKLKL
Q8NFH8 S631 Sugiyama REPS2 POB1 AIQTAIRKNKEANAVLARLNsELQQQLKEVHQERIALENQL
Q8NFI4 S181 Sugiyama ST13P5 FAM10A5 LQKPNAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
Q8NI08 S208 Sugiyama NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 DKLPDADLARKALKPIERVLsstsEEDEPGVVKFLKMNCRY
Q8TC07 S675 Sugiyama TBC1D15 TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q8WX93 S479 Sugiyama PALLD KIAA0992 CGI-151 VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q8WXH0 S2781 Sugiyama SYNE2 KIAA1011 NUA ILSQIRKCKVTHDGILARQQsVEsLAEEVKDKVPSLTTYEG
Q92530 S153 Sugiyama PSMF1 RIVSGIITPIHEQWEKANVssPHREFPPAtAREVDPLRIPP
Q92530 T162 Sugiyama PSMF1 IHEQWEKANVssPHREFPPAtAREVDPLRIPPHHPHTSRQP
Q92904 S65 EPSD|PSP DAZL DAZH DAZL1 DAZLA SPGYLA GGIDVRMDETEIRSFFARYGsVKEVKIITDRTGVSKGYGFV
Q92905 S177 PSP COPS5 CSN5 JAB1 LNQQFQEPFVAVVIDPTRTIsAGKVNLGAFRTYPKGYKPPD
Q92945 S181 Sugiyama KHSRP FUBP2 GRGGEQINKIQQDSGCKVQIsPDsGGLPERsVsLtGAPEsV
Q969V6 S312 EPSD|PSP MRTFA KIAA1438 MAL MKL1 PPKSAGEALGSsGtPPVRsLsttNSSSSsGAPGPCGLARQN
Q969V6 S333 EPSD|PSP MRTFA KIAA1438 MAL MKL1 ttNSSSSsGAPGPCGLARQNstsLtGKPGALPANLDDMKVA
Q96AE4 S630 Sugiyama FUBP1 DYSAAWAEYYRQQAAyyAQtsPQGMPQHPPAPQGQ______
Q96AE4 Y626 Sugiyama FUBP1 GGQPDYSAAWAEYYRQQAAyyAQtsPQGMPQHPPAPQGQ__
Q96B36 S212 Sugiyama AKT1S1 PRAS40 GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96BY7 S497 Sugiyama ATG2B C14orf103 PSNLVHPTPLQKtsLPsRsVsVDESRPELIFRLAVGTFSIS
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96D71 S767 Sugiyama REPS1 AIQAsIRRNKETNTVLARLNsELQQQLKDVLEERISLEVQL
Q96E11 S239 Sugiyama MRRF LKKSKDTVsEDtIRLIEKQIsQMADDtVAELDRHLAVKTKE
Q96FS4 S55 Sugiyama SIPA1 SPA1 PLTPHTFEPRPVRGPLLRsGsDAGEARPPtPAsPRARAHsH
Q96HE7 S173 Sugiyama ERO1A ERO1L UNQ434/PRO865 LQWTKHDDSSDNFCEADDIQsPEAEyVDLLLNPERYTGYKG
Q96IR7 S360 Sugiyama HPDL GLOXD1 LIQRQGATGFGQGNIRALWQsVQEQsARSQEA_________
Q96J92 S575 EPSD|PSP WNK4 PRKWNK4 PPEPEEPEADQHQPFLFRHAsYSSTTSDCETDGYLSSSGFL
Q96N67 S1432 Sugiyama DOCK7 KIAA1771 RRSRGQLGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWR
Q96P16 S109 Sugiyama RPRD1A P15RS FKHVSSETDESCKKHLGRVLsIWEERSVYENDVLEQLKQAL
Q99497 T154 Sugiyama PARK7 MNGGHytysENRVEKDGLILtSRGPGTSFEFALAIVEALNG
Q99575 S816 Sugiyama POP1 KIAA0061 VAATGSHLCVLRSRKLLKQLsAWCGPSSEDSRGGRRAPGRG
Q99618 S94 Sugiyama CDCA3 C8 GRCC8 TOME1 ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 S54 Sugiyama TUBA1C TUBA6 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BQE3 T56 Sugiyama TUBA1C TUBA6 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BQG0 S11 Sugiyama MYBBP1A P160 __________MEsRDPAQPMsPGEAtQsGARPADRYGLLKH
Q9BWH6 T1384 Sugiyama RPAP1 KIAA1403 FELYSQLPPLRQHYLQRLTStVLQNGVSET___________
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9BY66 S780 Sugiyama KDM5D HY HYA JARID1D KIAA0234 SMCY FDTWANKVRVALEVEDGRKRsFEELRALESEARERRFPNSE
Q9BZD4 S171 Sugiyama NUF2 CDCA1 NUF2R KMQQLNAAHQEALMKLERLDsVPVEEQEEFKQLSDGIQELQ
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2 S221 Sugiyama TNKS1BP1 KIAA1741 TAB182 TyGtTTAPRDEDGstLFRGWsQEGPVKsPAECREEHsKtPE
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9C0C2 S836 Sugiyama TNKS1BP1 KIAA1741 TAB182 GVLTAQDRVVGKPAQLGtQRsQEADVQDWEFRKRDsQGtys
Q9H2U2 S317 Sugiyama PPA2 HSPC124 DSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLGK___
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H8Y8 S451 Sugiyama GORASP2 GOLPH6 DstPVsEKPVsAAVDANAsEsP___________________
Q9HAP6 S115 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 ELPKTDEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLK
Q9HCN8 T70 Sugiyama SDF2L1 UNQ1941/PRO4424 RVRLHSHDIKYGSGSGQQSVtGVEAsDDANSyWRIRGGSEG
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQC3 S107 SIGNOR|PSP RTN4 KIAA0886 NOGO My043 SP1507 PPAPRGPLPAAPPVAPERQPsWDPsPVsstVPAPsPLsAAA
Q9NTJ3 S22 Sugiyama SMC4 CAPC SMC4L1 PRKGTQPSTARRREEGPPPPsPDGAssDAEPEPPsGRtEsP
Q9NUP9 S115 Sugiyama LIN7C MALS3 VELI3 ELPKTEEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLK
Q9NUU7 S92 Sugiyama DDX19A DDX19L NtNQVEVLQRDPNsPLysVKsFEELRLKPQLLQGVYAMGFN
Q9NY61 T366 SIGNOR|EPSD|PSP AATF CHE1 DED HSPC277 EDYPSFMAKRFADFTVYRNRtLQKWHDKTKLASGKLGKGFG
Q9P032 S45 Sugiyama NDUFAF4 C6orf66 HRPAP20 HSPC125 My013 MKPSVAPRHPsTNSLLREQIsLyPEVKGEIARKDEKLLSFL
Q9P2N2 S69 Sugiyama ARHGAP28 KIAA1314 RINRMLsNESLHPPAFsRSNsEASVDSASMEDFWREIESIK
Q9UGV2 S361 Sugiyama NDRG3 sPFsRsVtsNQsDGtQESCEsPDVLDRHQTMEVsC______
Q9UHB6 S490 Sugiyama LIMA1 EPLIN SREBP3 PP624 ENEEILERPAQLANAREtPHsPGVEDAPIAKVGVLAAsMEA
Q9UHI6 S268 Sugiyama DDX20 DP103 GEMIN3 EFLANALTKYMRDPTFVRLNsSDPSLIGLKQYYKVVNSYPL
Q9UKV8 S387 GPS6|SIGNOR|EPSD|PSP AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9ULD2 S1203 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9UMR2 S93 Sugiyama DDX19B DBP5 DDX19 TDBP NtNQVEVLQRDPNsPLysVKsFEELRLKPQLLQGVYAMGFN
Q9UMZ2 S752 Sugiyama SYNRG AP1GBP1 SYNG VKGGQNSTAASTKyDVFRQLsLEGsGLGVEDLKDNtPSGKs
Q9UNH7 S316 Sugiyama SNX6 LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPN3 S2769 Sugiyama MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251 EAIEKRLISPELANMIQIDSsEFSDHRAQIEKQEGIEVCAL
Q9UPN4 S47 EPSD|PSP CEP131 AZI1 KIAA1118 PPVSRRPGsAATtKPIVRsVsVVTGsEQKRKVLEATGPGGS
Q9UPN4 S78 EPSD|PSP CEP131 AZI1 KIAA1118 VLEATGPGGSQAINNLRRsNsttQVSQPRsGsPRPtEPtDF
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y385 S184 SIGNOR UBE2J1 NCUBE1 CGI-76 HSPC153 HSPC205 KSGSDSSQADQEAKELARQIsFKAEVNSSGKTISESDLNHS
Q9Y3X0 S386 Sugiyama CCDC9 DRWETKEGAAsPAPEtPQPtsPEtsPKETPMQPPEIPAPAH
Q9Y3X0 T381 Sugiyama CCDC9 YsDHDDRWETKEGAAsPAPEtPQPtsPEtsPKETPMQPPEI
Q9Y4H2 S1203 Sugiyama IRS2 RKssEGGVGVGPGGGDEPPtsPRQLQPAPPLAPQGRPWtPG
Q9Y580 S136 PSP|Sugiyama RBM7 RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y580 S204 PSP RBM7 SSSSQWRQGTPSSQRKVRMNsyPYLADRHYSREQRYTDHGs
Q9Y5A9 S394 Sugiyama YTHDF2 HGRG8 SQAGSGStPSEPHPVLEKLRsINNYNPKDFDWNLKHGRVFI
Q9Y6G9 S516 Sugiyama DYNC1LI1 DNCLI1 HAELDRITRKPVtVsPttPtsPtEGEAs_____________
Q9Y6G9 T513 Sugiyama DYNC1LI1 DNCLI1 LDVHAELDRITRKPVtVsPttPtsPtEGEAs__________
Q9Y6G9 T515 Sugiyama DYNC1LI1 DNCLI1 VHAELDRITRKPVtVsPttPtsPtEGEAs____________
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000007 5.148 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.000026 4.577 0 0
Apoptotic execution phase R-HSA-75153 0.000042 4.373 0 0
NRAGE signals death through JNK R-HSA-193648 0.000040 4.400 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.000054 4.269 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.000312 3.506 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.000325 3.488 0 0
Signaling by Hippo R-HSA-2028269 0.000840 3.076 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.000871 3.060 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.000883 3.054 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.000936 3.029 0 0
Calmodulin induced events R-HSA-111933 0.001121 2.950 0 0
CaM pathway R-HSA-111997 0.001121 2.950 0 0
mRNA Splicing R-HSA-72172 0.001212 2.916 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.001193 2.923 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.001477 2.831 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.001444 2.840 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.001595 2.797 0 0
Cell Cycle Checkpoints R-HSA-69620 0.001605 2.795 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.001775 2.751 0 0
Cell Cycle R-HSA-1640170 0.001982 2.703 0 0
Nervous system development R-HSA-9675108 0.002071 2.684 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.002273 2.643 0 0
RAF activation R-HSA-5673000 0.002218 2.654 0 0
Chromatin modifying enzymes R-HSA-3247509 0.002302 2.638 0 0
Chromatin organization R-HSA-4839726 0.002367 2.626 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.002476 2.606 0 0
Post NMDA receptor activation events R-HSA-438064 0.002562 2.591 0 0
MAPK family signaling cascades R-HSA-5683057 0.002533 2.596 0 0
HATs acetylate histones R-HSA-3214847 0.002872 2.542 0 0
Cell Cycle, Mitotic R-HSA-69278 0.002929 2.533 0 0
Neurexins and neuroligins R-HSA-6794361 0.003030 2.519 0 0
G alpha (12/13) signalling events R-HSA-416482 0.003588 2.445 0 0
Signal Transduction R-HSA-162582 0.003681 2.434 1 0
Ca-dependent events R-HSA-111996 0.004029 2.395 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.004171 2.380 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.004253 2.371 0 0
Axon guidance R-HSA-422475 0.004689 2.329 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.005526 2.258 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.007682 2.115 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.007682 2.115 0 0
Type I hemidesmosome assembly R-HSA-446107 0.007656 2.116 0 0
Activation of RAC1 R-HSA-428540 0.006612 2.180 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.006879 2.162 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.006225 2.206 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.007438 2.129 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.007438 2.129 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.007438 2.129 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.007037 2.153 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.007626 2.118 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.006363 2.196 0 0
Signaling by RAS mutants R-HSA-6802949 0.007438 2.129 0 0
Homology Directed Repair R-HSA-5693538 0.006619 2.179 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.007051 2.152 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.007032 2.153 0 0
DAG and IP3 signaling R-HSA-1489509 0.006426 2.192 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.005761 2.240 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.007619 2.118 0 0
Interleukin-12 signaling R-HSA-9020591 0.006076 2.216 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.007722 2.112 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.007934 2.100 0 0
Meiotic synapsis R-HSA-1221632 0.008323 2.080 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.008709 2.060 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.008808 2.055 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.008808 2.055 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.008596 2.066 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.008837 2.054 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.008902 2.051 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.009123 2.040 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.010012 1.999 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.010577 1.976 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.010577 1.976 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.010142 1.994 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.010329 1.986 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.010577 1.976 0 0
Interleukin-12 family signaling R-HSA-447115 0.010786 1.967 0 0
Lipophagy R-HSA-9613354 0.010837 1.965 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.010837 1.965 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.012045 1.919 0 0
PKA activation R-HSA-163615 0.014224 1.847 0 0
PKA activation in glucagon signalling R-HSA-164378 0.014224 1.847 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.013704 1.863 0 0
HSF1-dependent transactivation R-HSA-3371571 0.014523 1.838 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.014820 1.829 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.014505 1.838 1 1
Regulation of TP53 Activity R-HSA-5633007 0.014559 1.837 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.013745 1.862 0 0
M Phase R-HSA-68886 0.015659 1.805 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.015789 1.802 0 0
Apoptosis R-HSA-109581 0.016651 1.779 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.017317 1.762 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.017318 1.762 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.017952 1.746 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.018486 1.733 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.018628 1.730 0 0
Neurodegenerative Diseases R-HSA-8863678 0.018628 1.730 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.018924 1.723 0 0
DCC mediated attractive signaling R-HSA-418885 0.019091 1.719 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.019091 1.719 0 0
Signaling by FGFR in disease R-HSA-1226099 0.020359 1.691 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.020359 1.691 0 0
Cellular Senescence R-HSA-2559583 0.021441 1.669 1 0
PIP3 activates AKT signaling R-HSA-1257604 0.021455 1.668 0 0
PLC beta mediated events R-HSA-112043 0.021557 1.666 0 0
Long-term potentiation R-HSA-9620244 0.022088 1.656 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.022102 1.656 0 0
Diseases of programmed cell death R-HSA-9645723 0.022582 1.646 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.023344 1.632 0 0
Mitotic Prophase R-HSA-68875 0.024611 1.609 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.023948 1.621 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.024658 1.608 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.024867 1.604 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 0.025562 1.592 0 0
G0 and Early G1 R-HSA-1538133 0.025564 1.592 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.028665 1.543 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.028665 1.543 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.028665 1.543 0 0
Dopamine receptors R-HSA-390651 0.028665 1.543 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.028665 1.543 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.029140 1.536 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.029438 1.531 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.029438 1.531 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.029566 1.529 0 0
Netrin-1 signaling R-HSA-373752 0.029920 1.524 0 0
Deubiquitination R-HSA-5688426 0.030268 1.519 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.030322 1.518 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.031898 1.496 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.032271 1.491 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.034655 1.460 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.033497 1.475 0 0
Specification of primordial germ cells R-HSA-9827857 0.035263 1.453 0 0
Interleukin-2 family signaling R-HSA-451927 0.036027 1.443 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.038442 1.415 0 0
DNA Double Strand Break Response R-HSA-5693606 0.038942 1.410 0 0
G-protein mediated events R-HSA-112040 0.038942 1.410 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.039331 1.405 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.042083 1.376 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.040095 1.397 0 0
Ephrin signaling R-HSA-3928664 0.042157 1.375 0 0
DNA methylation R-HSA-5334118 0.040448 1.393 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.040448 1.393 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.040514 1.392 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.043009 1.366 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.043477 1.362 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.040095 1.397 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.043667 1.360 0 0
Cellular response to heat stress R-HSA-3371556 0.043882 1.358 1 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.045148 1.345 1 0
Signaling by FGFR1 in disease R-HSA-5655302 0.045369 1.343 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.045369 1.343 0 0
Signaling by NTRKs R-HSA-166520 0.045442 1.343 1 0
HDACs deacetylate histones R-HSA-3214815 0.046868 1.329 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.046893 1.329 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 0.048574 1.314 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.049843 1.302 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.058106 1.236 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.058106 1.236 0 0
Meiosis R-HSA-1500620 0.052665 1.278 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.058106 1.236 0 0
Ub-specific processing proteases R-HSA-5689880 0.052759 1.278 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.058106 1.236 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.058923 1.230 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.058923 1.230 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.063220 1.199 0 0
Death Receptor Signaling R-HSA-73887 0.063220 1.199 1 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.071281 1.147 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.071281 1.147 0 0
Regulation of cortical dendrite branching R-HSA-8985801 0.071281 1.147 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.071281 1.147 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.071281 1.147 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.071281 1.147 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.071281 1.147 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.071281 1.147 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.071281 1.147 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.071281 1.147 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.071281 1.147 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.071281 1.147 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.066883 1.175 0 0
mRNA 3'-end processing R-HSA-72187 0.068255 1.166 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.067704 1.169 0 0
Signaling by ROBO receptors R-HSA-376176 0.071184 1.148 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.070073 1.154 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.068313 1.165 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.066883 1.175 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.072447 1.140 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.072447 1.140 0 0
Packaging Of Telomere Ends R-HSA-171306 0.072447 1.140 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.072447 1.140 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 0.072447 1.140 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.072777 1.138 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.103149 0.987 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.195663 0.708 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.195663 0.708 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.195663 0.708 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 0.195663 0.708 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 0.195663 0.708 0 0
TICAM1 deficiency - HSE R-HSA-5602566 0.195663 0.708 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 0.195663 0.708 0 0
TWIK-related spinal cord K+ channel (TRESK) R-HSA-1299344 0.195663 0.708 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.195663 0.708 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 0.195663 0.708 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.195663 0.708 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 0.195663 0.708 0 0
MET activates PTPN11 R-HSA-8865999 0.103904 0.983 0 0
HCN channels R-HSA-1296061 0.139679 0.855 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 0.139679 0.855 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.139679 0.855 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 0.139679 0.855 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 0.139679 0.855 0 0
FGFR4 mutant receptor activation R-HSA-1839128 0.278639 0.555 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 0.278639 0.555 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 0.278639 0.555 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 0.278639 0.555 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 0.278639 0.555 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 0.278639 0.555 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 0.278639 0.555 0 0
TRAF3 deficiency - HSE R-HSA-5602571 0.278639 0.555 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 0.278639 0.555 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 0.278639 0.555 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 0.278639 0.555 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.097246 1.012 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.097246 1.012 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.177611 0.751 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.177611 0.751 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.177611 0.751 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 0.177611 0.751 0 0
G2 Phase R-HSA-68911 0.177611 0.751 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.083326 1.079 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.099443 1.002 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.099443 1.002 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.099443 1.002 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.099443 1.002 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.099443 1.002 0 0
Calcineurin activates NFAT R-HSA-2025928 0.144290 0.841 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.216875 0.664 0 0
Signaling by MAPK mutants R-HSA-9652817 0.216875 0.664 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 0.353059 0.452 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 0.353059 0.452 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 0.353059 0.452 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 0.353059 0.452 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 0.353059 0.452 0 0
Potassium transport channels R-HSA-1296067 0.353059 0.452 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.116881 0.932 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.170130 0.769 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.170130 0.769 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.135542 0.868 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.135542 0.868 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.256792 0.590 0 0
STAT5 Activation R-HSA-9645135 0.256792 0.590 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.256792 0.590 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.109190 0.962 0 0
GAB1 signalosome R-HSA-180292 0.109190 0.962 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.197165 0.705 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.197165 0.705 0 0
Signaling by APC mutants R-HSA-4839744 0.197165 0.705 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.197165 0.705 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.197165 0.705 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.197165 0.705 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.155318 0.809 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.124229 0.906 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.124229 0.906 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.124229 0.906 0 0
HIV elongation arrest and recovery R-HSA-167287 0.081709 1.088 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.081709 1.088 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.074837 1.126 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.112861 0.947 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.176090 0.754 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.176090 0.754 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.225140 0.648 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.296811 0.528 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.296811 0.528 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 0.296811 0.528 0 0
SOS-mediated signalling R-HSA-112412 0.296811 0.528 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.296811 0.528 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 0.419806 0.377 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.419806 0.377 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.419806 0.377 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 0.419806 0.377 0 0
Invadopodia formation R-HSA-8941237 0.419806 0.377 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.419806 0.377 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.197738 0.704 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.197738 0.704 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.197738 0.704 0 0
Trafficking of AMPA receptors R-HSA-399719 0.113360 0.946 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.253812 0.595 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.253812 0.595 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.112081 0.950 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.154643 0.811 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.154643 0.811 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.220137 0.657 0 0
MET receptor recycling R-HSA-8875656 0.336486 0.473 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.336486 0.473 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 0.336486 0.473 0 0
Formation of annular gap junctions R-HSA-196025 0.336486 0.473 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.336486 0.473 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.100547 0.998 0 0
FGFR3 mutant receptor activation R-HSA-2033514 0.282955 0.548 0 0
CD28 dependent Vav1 pathway R-HSA-389359 0.282955 0.548 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 0.282955 0.548 0 0
Adenylate cyclase activating pathway R-HSA-170660 0.282955 0.548 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.133872 0.873 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.243165 0.614 0 0
Transcription of the HIV genome R-HSA-167172 0.077385 1.111 0 0
HIV Transcription Elongation R-HSA-167169 0.145519 0.837 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.145519 0.837 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.145519 0.837 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.145519 0.837 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.157644 0.802 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.178064 0.749 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.202159 0.694 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.202159 0.694 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.266697 0.574 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 0.312360 0.505 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.312360 0.505 0 0
ARMS-mediated activation R-HSA-170984 0.375462 0.425 0 0
Interleukin-21 signaling R-HSA-9020958 0.375462 0.425 0 0
WNT mediated activation of DVL R-HSA-201688 0.375462 0.425 0 0
Gap junction degradation R-HSA-190873 0.375462 0.425 0 0
ATP sensitive Potassium channels R-HSA-1296025 0.479670 0.319 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.479670 0.319 0 0
betaKlotho-mediated ligand binding R-HSA-1307965 0.479670 0.319 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.479670 0.319 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.479670 0.319 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 0.479670 0.319 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.479670 0.319 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.479670 0.319 0 0
Signaling by MAP2K mutants R-HSA-9652169 0.479670 0.319 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.479670 0.319 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 0.479670 0.319 0 0
MAP2K and MAPK activation R-HSA-5674135 0.170228 0.769 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.192583 0.715 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.115492 0.937 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.219066 0.659 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.219066 0.659 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.251018 0.600 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.110825 0.955 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.290615 0.537 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.290615 0.537 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.290615 0.537 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.290615 0.537 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.290615 0.537 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.138287 0.859 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.341834 0.466 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 0.341834 0.466 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 0.341834 0.466 0 0
Centrosome maturation R-HSA-380287 0.126262 0.899 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.157709 0.802 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.157709 0.802 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.150071 0.824 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.254186 0.595 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.314803 0.502 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 0.413462 0.384 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.272296 0.565 0 0
Phosphorylation of the APC/C R-HSA-176412 0.371205 0.430 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.371205 0.430 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.179168 0.747 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.339152 0.470 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.212177 0.673 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.312970 0.504 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.312970 0.504 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.224538 0.649 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.334091 0.476 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.334091 0.476 0 0
Late endosomal microautophagy R-HSA-9615710 0.334091 0.476 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.334091 0.476 0 0
Notch-HLH transcription pathway R-HSA-350054 0.363559 0.439 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.400320 0.398 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.400320 0.398 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.400320 0.398 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 0.450272 0.347 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.450272 0.347 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.450272 0.347 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 0.533360 0.273 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 0.533360 0.273 0 0
IRS activation R-HSA-74713 0.533360 0.273 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.533360 0.273 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.235264 0.628 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.233009 0.633 0 0
RUNX2 regulates bone development R-HSA-8941326 0.328196 0.484 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.355329 0.449 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.300081 0.523 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.387925 0.411 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.429044 0.367 0 0
Metabolism of non-coding RNA R-HSA-194441 0.309730 0.509 0 0
snRNP Assembly R-HSA-191859 0.309730 0.509 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.331755 0.479 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.412161 0.385 0 0
Deadenylation of mRNA R-HSA-429947 0.412161 0.385 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.485733 0.314 0 0
ERKs are inactivated R-HSA-202670 0.485733 0.314 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.255334 0.593 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.356696 0.448 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.457258 0.340 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.331613 0.479 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.374162 0.427 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.286244 0.543 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.404502 0.393 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.484864 0.314 0 0
Polymerase switching R-HSA-69091 0.519732 0.284 0 0
Leading Strand Synthesis R-HSA-69109 0.519732 0.284 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.519732 0.284 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.519732 0.284 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.581513 0.235 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.581513 0.235 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.581513 0.235 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 0.581513 0.235 0 0
Cam-PDE 1 activation R-HSA-111957 0.581513 0.235 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 0.581513 0.235 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.581513 0.235 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 0.581513 0.235 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.581513 0.235 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 0.581513 0.235 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.442562 0.354 0 0
HIV Transcription Initiation R-HSA-167161 0.442562 0.354 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.442562 0.354 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.461035 0.336 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.461035 0.336 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.461035 0.336 0 0
Cristae formation R-HSA-8949613 0.483305 0.316 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.511774 0.291 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.480113 0.319 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.506272 0.296 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.506272 0.296 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.502051 0.299 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.498605 0.302 0 0
Lagging Strand Synthesis R-HSA-69186 0.537921 0.269 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.537921 0.269 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.495672 0.305 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.486824 0.313 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.516863 0.287 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.550756 0.259 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.563246 0.249 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.563246 0.249 0 0
Removal of the Flap Intermediate R-HSA-69166 0.583072 0.234 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.583072 0.234 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 0.583072 0.234 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 0.583072 0.234 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.552565 0.258 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.544284 0.264 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.587707 0.231 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.587707 0.231 0 0
FGFR2 alternative splicing R-HSA-6803529 0.587707 0.231 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.584925 0.233 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.591154 0.228 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.591154 0.228 0 0
FOXO-mediated transcription R-HSA-9614085 0.535899 0.271 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.170421 0.768 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.091788 1.037 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.418877 0.378 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.122721 0.911 0 0
Specification of the neural plate border R-HSA-9834899 0.266697 0.574 0 0
Recycling pathway of L1 R-HSA-437239 0.552565 0.258 0 0
Signaling by EGFR R-HSA-177929 0.266369 0.575 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.552193 0.258 0 0
MET promotes cell motility R-HSA-8875878 0.541794 0.266 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.481682 0.317 0 0
EGFR downregulation R-HSA-182971 0.572188 0.242 0 0
ESR-mediated signaling R-HSA-8939211 0.307020 0.513 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.517982 0.286 0 0
Prolonged ERK activation events R-HSA-169893 0.176090 0.754 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.197030 0.705 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.197030 0.705 0 0
EPH-Ephrin signaling R-HSA-2682334 0.152932 0.816 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.080564 1.094 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.400320 0.398 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.528771 0.277 0 0
RNA Polymerase III Transcription R-HSA-74158 0.502051 0.299 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.197030 0.705 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.176090 0.754 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.169182 0.772 0 0
TGFBR3 expression R-HSA-9839394 0.436186 0.360 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.209352 0.679 0 0
Nucleotide Excision Repair R-HSA-5696398 0.397941 0.400 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.119094 0.924 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.355329 0.449 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.519732 0.284 0 0
Signaling by FGFR4 R-HSA-5654743 0.480113 0.319 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.074837 1.126 0 0
Frs2-mediated activation R-HSA-170968 0.282955 0.548 0 0
Co-stimulation by CD28 R-HSA-389356 0.269155 0.570 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.144290 0.841 0 0
RET signaling R-HSA-8853659 0.101964 0.992 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.137552 0.862 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.502051 0.299 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.461035 0.336 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.157644 0.802 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.363559 0.439 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.400320 0.398 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.459774 0.337 0 0
UCH proteinases R-HSA-5689603 0.563600 0.249 0 0
Signaling by FGFR3 R-HSA-5654741 0.356696 0.448 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.297935 0.526 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.528771 0.277 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.241261 0.618 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.097246 1.012 0 0
Regulation of CDH11 function R-HSA-9762292 0.170130 0.769 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.225140 0.648 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.375462 0.425 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.254186 0.595 0 0
Attenuation phase R-HSA-3371568 0.254849 0.594 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 0.581513 0.235 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.587707 0.231 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.303754 0.517 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.243165 0.614 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.169182 0.772 0 0
Myogenesis R-HSA-525793 0.459923 0.337 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.550756 0.259 0 0
Signalling to ERKs R-HSA-187687 0.178064 0.749 1 0
Hedgehog 'off' state R-HSA-5610787 0.326987 0.485 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.426664 0.370 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.314166 0.503 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.168725 0.773 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.563246 0.249 0 0
Telomere Maintenance R-HSA-157579 0.292665 0.534 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.549369 0.260 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.139679 0.855 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.083326 1.079 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.075671 1.121 0 0
Sodium/Proton exchangers R-HSA-425986 0.336486 0.473 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.375462 0.425 0 0
Regulation of gap junction activity R-HSA-191650 0.479670 0.319 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.112229 0.950 0 0
Separation of Sister Chromatids R-HSA-2467813 0.102782 0.988 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 0.533360 0.273 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.484864 0.314 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 0.581513 0.235 0 0
Formation of axial mesoderm R-HSA-9796292 0.552193 0.258 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.113352 0.946 0 0
Signaling by FGFR R-HSA-190236 0.523326 0.281 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.459923 0.337 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.461420 0.336 0 0
Chromosome Maintenance R-HSA-73886 0.503259 0.298 0 0
Nuclear RNA decay R-HSA-9930044 0.137552 0.862 0 0
S Phase R-HSA-69242 0.204712 0.689 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.369625 0.432 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.271361 0.566 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.138134 0.860 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.138134 0.860 0 0
TRP channels R-HSA-3295583 0.140025 0.854 0 0
ERK/MAPK targets R-HSA-198753 0.314803 0.502 0 0
Signal attenuation R-HSA-74749 0.413462 0.384 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.359930 0.444 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.440153 0.356 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.519732 0.284 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.519732 0.284 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.481682 0.317 0 0
RNA Polymerase I Transcription R-HSA-73864 0.460315 0.337 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.561099 0.251 0 0
Integrin signaling R-HSA-354192 0.137552 0.862 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.194797 0.710 0 0
MET activates RAS signaling R-HSA-8851805 0.253812 0.595 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.222949 0.652 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.119122 0.924 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.431657 0.365 0 0
Signalling to RAS R-HSA-167044 0.537921 0.269 1 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.541794 0.266 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.251018 0.600 0 0
Mitotic Anaphase R-HSA-68882 0.125823 0.900 0 0
Insulin receptor signalling cascade R-HSA-74751 0.384807 0.415 0 0
TCR signaling R-HSA-202403 0.567966 0.246 0 0
Ca2+ activated K+ channels R-HSA-1296052 0.296811 0.528 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.197738 0.704 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.150519 0.822 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.157644 0.802 0 0
Defective pyroptosis R-HSA-9710421 0.196685 0.706 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.224538 0.649 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 0.533360 0.273 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.533360 0.273 0 0
Activation of AKT2 R-HSA-165158 0.533360 0.273 0 0
IRS-mediated signalling R-HSA-112399 0.280625 0.552 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.429044 0.367 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.130517 0.884 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.485733 0.314 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.419087 0.378 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.483305 0.316 0 0
Negative regulation of MET activity R-HSA-6807004 0.511774 0.291 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.488735 0.311 0 0
Aggrephagy R-HSA-9646399 0.579985 0.237 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.292665 0.534 0 0
Cyclin D associated events in G1 R-HSA-69231 0.339306 0.469 0 0
G1 Phase R-HSA-69236 0.339306 0.469 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.175033 0.757 1 1
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.272296 0.565 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.347181 0.459 0 0
Signaling by NOTCH1 R-HSA-1980143 0.563600 0.249 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.284509 0.546 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.284509 0.546 0 0
Activation of BH3-only proteins R-HSA-114452 0.355329 0.449 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.356696 0.448 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.116881 0.932 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.328196 0.484 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.519732 0.284 0 0
Proteasome assembly R-HSA-9907900 0.498605 0.302 0 0
MTOR signalling R-HSA-165159 0.183249 0.737 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.455004 0.342 0 0
Gene expression (Transcription) R-HSA-74160 0.214181 0.669 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.219321 0.659 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.147832 0.830 0 0
Signaling by VEGF R-HSA-194138 0.197030 0.705 1 0
Nef and signal transduction R-HSA-164944 0.076564 1.116 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 0.139679 0.855 0 0
CHL1 interactions R-HSA-447041 0.097246 1.012 0 0
Polo-like kinase mediated events R-HSA-156711 0.109190 0.962 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.207556 0.683 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.413462 0.384 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.363559 0.439 0 0
Mitotic Prometaphase R-HSA-68877 0.092938 1.032 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 0.581513 0.235 0 0
Processing of SMDT1 R-HSA-8949664 0.552193 0.258 0 0
GPVI-mediated activation cascade R-HSA-114604 0.502051 0.299 0 0
Degradation of CDH1 R-HSA-9766229 0.587010 0.231 0 0
RNA Polymerase II Transcription R-HSA-73857 0.296680 0.528 0 0
Signaling by WNT R-HSA-195721 0.364078 0.439 0 0
IGF1R signaling cascade R-HSA-2428924 0.263178 0.580 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.363559 0.439 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.412161 0.385 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.194788 0.710 0 0
Oncogene Induced Senescence R-HSA-2559585 0.481682 0.317 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.081757 1.087 1 0
Generic Transcription Pathway R-HSA-212436 0.455381 0.342 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.119907 0.921 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.137552 0.862 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.169901 0.770 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.290615 0.537 0 0
TBC/RABGAPs R-HSA-8854214 0.196685 0.706 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.334091 0.476 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.485733 0.314 0 0
Regulation of signaling by CBL R-HSA-912631 0.484864 0.314 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.407104 0.390 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.254849 0.594 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.423576 0.373 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 0.296811 0.528 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.371205 0.430 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.256157 0.591 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.231085 0.636 0 0
Opioid Signalling R-HSA-111885 0.194797 0.710 0 0
Co-inhibition by PD-1 R-HSA-389948 0.514653 0.288 0 0
DNA Repair R-HSA-73894 0.131948 0.880 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.103571 0.985 0 0
Signaling by SCF-KIT R-HSA-1433557 0.480113 0.319 0 0
Semaphorin interactions R-HSA-373755 0.157709 0.802 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.341874 0.466 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.276515 0.558 0 0
Metabolism of RNA R-HSA-8953854 0.318545 0.497 1 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.154643 0.811 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.098518 1.006 0 0
HIV Life Cycle R-HSA-162587 0.107796 0.967 0 0
L1CAM interactions R-HSA-373760 0.256717 0.591 0 0
Autophagy R-HSA-9612973 0.201836 0.695 0 0
Neuronal System R-HSA-112316 0.228658 0.641 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 0.139679 0.855 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.119907 0.921 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.144290 0.841 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 0.216875 0.664 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.353059 0.452 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 0.353059 0.452 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 0.353059 0.452 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.170130 0.769 0 0
Signaling by AXIN mutants R-HSA-4839735 0.225140 0.648 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.225140 0.648 0 0
MET interacts with TNS proteins R-HSA-8875513 0.419806 0.377 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 0.419806 0.377 0 0
Signaling by LTK R-HSA-9842663 0.253812 0.595 0 0
Adrenoceptors R-HSA-390696 0.336486 0.473 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.336486 0.473 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 0.336486 0.473 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.243165 0.614 0 0
Meiotic recombination R-HSA-912446 0.115700 0.937 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.312360 0.505 0 0
cGMP effects R-HSA-418457 0.312360 0.505 0 0
Alanine metabolism R-HSA-8964540 0.479670 0.319 0 0
PI3K Cascade R-HSA-109704 0.186471 0.729 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.238726 0.622 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.224696 0.648 0 0
Nucleosome assembly R-HSA-774815 0.224696 0.648 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 0.371205 0.430 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.312970 0.504 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.290702 0.537 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.169676 0.770 0 0
mTORC1-mediated signalling R-HSA-166208 0.363559 0.439 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.347181 0.459 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.429044 0.367 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.485733 0.314 0 0
Smooth Muscle Contraction R-HSA-445355 0.347797 0.459 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.457258 0.340 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.317134 0.499 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 0.581513 0.235 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.581513 0.235 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 0.581513 0.235 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 0.552193 0.258 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.458580 0.339 1 1
Organelle biogenesis and maintenance R-HSA-1852241 0.523422 0.281 0 0
Membrane Trafficking R-HSA-199991 0.283768 0.547 0 0
Programmed Cell Death R-HSA-5357801 0.113296 0.946 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.125158 0.903 0 0
FLT3 signaling in disease R-HSA-9682385 0.328196 0.484 0 0
Heme signaling R-HSA-9707616 0.147832 0.830 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.354502 0.450 0 0
Generation of second messenger molecules R-HSA-202433 0.254849 0.594 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.374056 0.427 0 0
DNA Replication R-HSA-69306 0.495457 0.305 0 0
FLT3 Signaling R-HSA-9607240 0.157644 0.802 0 0
HIV Infection R-HSA-162906 0.236385 0.626 0 0
Sensory processing of sound R-HSA-9659379 0.244480 0.612 0 0
G2/M Checkpoints R-HSA-69481 0.150899 0.821 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.423069 0.374 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.341834 0.466 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.137552 0.862 0 0
Macroautophagy R-HSA-1632852 0.279409 0.554 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.528771 0.277 1 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.275613 0.560 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.275613 0.560 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.256792 0.590 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 0.197738 0.704 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.174490 0.758 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.211724 0.674 0 0
Rap1 signalling R-HSA-392517 0.484864 0.314 0 0
Rab regulation of trafficking R-HSA-9007101 0.356362 0.448 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.528771 0.277 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.528771 0.277 0 0
Cell junction organization R-HSA-446728 0.183287 0.737 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.478625 0.320 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.088671 1.052 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.174490 0.758 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.211636 0.674 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.103546 0.985 1 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.209352 0.679 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.457258 0.340 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 0.552193 0.258 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.165782 0.780 0 0
Ion homeostasis R-HSA-5578775 0.396381 0.402 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.550756 0.259 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.445958 0.351 0 0
Adherens junctions interactions R-HSA-418990 0.519513 0.284 0 0
Cell-cell junction organization R-HSA-421270 0.562299 0.250 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 0.083326 1.079 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.216875 0.664 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.155318 0.809 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 0.479670 0.319 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.103546 0.985 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.272296 0.565 0 0
Muscarinic acetylcholine receptors R-HSA-390648 0.533360 0.273 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.374162 0.427 0 0
Cell-Cell communication R-HSA-1500931 0.160799 0.794 0 0
GPER1 signaling R-HSA-9634597 0.409181 0.388 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 0.581513 0.235 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.461175 0.336 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 0.583072 0.234 0 0
PI Metabolism R-HSA-1483255 0.177469 0.751 0 0
Cellular responses to stimuli R-HSA-8953897 0.332989 0.478 1 0
The NLRP3 inflammasome R-HSA-844456 0.484864 0.314 0 0
Cellular responses to stress R-HSA-2262752 0.440687 0.356 1 0
Reproduction R-HSA-1474165 0.083820 1.077 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.105967 0.975 0 0
Regulation of KIT signaling R-HSA-1433559 0.312360 0.505 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.266369 0.575 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.436186 0.360 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.205797 0.687 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.292036 0.535 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.109190 0.962 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.197738 0.704 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.280071 0.553 0 0
G2/M Transition R-HSA-69275 0.184213 0.735 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.459923 0.337 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.572188 0.242 0 0
Amine ligand-binding receptors R-HSA-375280 0.339306 0.469 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.150071 0.824 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.192746 0.715 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.459923 0.337 0 0
NGF-stimulated transcription R-HSA-9031628 0.162506 0.789 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.387925 0.411 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.452708 0.344 0 0
Signaling by KIT in disease R-HSA-9669938 0.363559 0.439 0 0
Protein ubiquitination R-HSA-8852135 0.297935 0.526 0 0
DSCAM interactions R-HSA-376172 0.353059 0.452 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 0.116881 0.932 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.243165 0.614 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.375462 0.425 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 0.375462 0.425 0 0
Sensory perception of sour taste R-HSA-9729555 0.479670 0.319 0 0
Protein methylation R-HSA-8876725 0.341834 0.466 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.254186 0.595 0 0
Tandem pore domain potassium channels R-HSA-1296346 0.413462 0.384 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.371205 0.430 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.334091 0.476 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.450272 0.347 0 0
Synthesis of PI R-HSA-1483226 0.450272 0.347 0 0
PTK6 Down-Regulation R-HSA-8849472 0.533360 0.273 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 0.533360 0.273 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.356696 0.448 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 0.581513 0.235 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.583072 0.234 0 0
Selective autophagy R-HSA-9663891 0.368157 0.434 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.157709 0.802 0 0
Signaling by PTK6 R-HSA-8848021 0.157709 0.802 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.480113 0.319 0 0
Base Excision Repair R-HSA-73884 0.286795 0.542 0 0
Downstream signal transduction R-HSA-186763 0.376616 0.424 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.436186 0.360 0 0
Mitochondrial biogenesis R-HSA-1592230 0.457304 0.340 0 0
Glycolysis R-HSA-70171 0.433633 0.363 0 0
Amyloid fiber formation R-HSA-977225 0.268025 0.572 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.144290 0.841 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 0.116881 0.932 0 0
Signal regulatory protein family interactions R-HSA-391160 0.312360 0.505 0 0
Interleukin-6 signaling R-HSA-1059683 0.552193 0.258 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.150519 0.822 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.086025 1.065 0 0
Nephron development R-HSA-9831926 0.109190 0.962 0 0
Glycogen metabolism R-HSA-8982491 0.579985 0.237 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.256792 0.590 0 0
Histamine receptors R-HSA-390650 0.419806 0.377 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.129082 0.889 0 0
Nuclear import of Rev protein R-HSA-180746 0.290702 0.537 0 0
PECAM1 interactions R-HSA-210990 0.450272 0.347 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.583072 0.234 0 0
Signaling by Interleukins R-HSA-449147 0.484041 0.315 1 0
Inositol phosphate metabolism R-HSA-1483249 0.376404 0.424 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.101842 0.992 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.089874 1.046 0 0
OAS antiviral response R-HSA-8983711 0.253812 0.595 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.356696 0.448 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.334512 0.476 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 0.144290 0.841 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 0.216875 0.664 0 0
Regulation of PTEN localization R-HSA-8948747 0.296811 0.528 0 0
Interleukin-18 signaling R-HSA-9012546 0.336486 0.473 0 0
DARPP-32 events R-HSA-180024 0.334091 0.476 0 0
Bicarbonate transporters R-HSA-425381 0.450272 0.347 0 0
NrCAM interactions R-HSA-447038 0.533360 0.273 0 0
Co-inhibition by BTLA R-HSA-9927353 0.533360 0.273 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.404502 0.393 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.423576 0.373 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.461420 0.336 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 0.552193 0.258 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.552193 0.258 0 0
Stimuli-sensing channels R-HSA-2672351 0.433951 0.363 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.474563 0.324 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.563246 0.249 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.156941 0.804 0 0
Interleukin-15 signaling R-HSA-8983432 0.253812 0.595 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.140025 0.854 0 0
Glucose metabolism R-HSA-70326 0.563462 0.249 0 0
Cleavage of the damaged purine R-HSA-110331 0.207556 0.683 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.160452 0.795 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.137120 0.863 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.413462 0.384 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.363559 0.439 0 0
Signaling by ALK in cancer R-HSA-9700206 0.160452 0.795 0 0
Depurination R-HSA-73927 0.222949 0.652 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 0.353059 0.452 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.125158 0.903 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.282955 0.548 0 0
Formation of intermediate mesoderm R-HSA-9761174 0.413462 0.384 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.369625 0.432 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.137552 0.862 0 0
Kidney development R-HSA-9830369 0.570144 0.244 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.385381 0.414 0 0
Interleukin-2 signaling R-HSA-9020558 0.450272 0.347 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.363935 0.439 0 0
Zinc transporters R-HSA-435354 0.583072 0.234 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.183249 0.737 0 0
Depyrimidination R-HSA-73928 0.183249 0.737 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.083336 1.079 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.541794 0.266 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 0.533360 0.273 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.331755 0.479 0 0
Gene Silencing by RNA R-HSA-211000 0.319841 0.495 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 0.519732 0.284 0 0
Interleukin-37 signaling R-HSA-9008059 0.550756 0.259 0 0
Cilium Assembly R-HSA-5617833 0.591687 0.228 0 0
DNA strand elongation R-HSA-69190 0.593032 0.227 0 0
Signaling by WNT in cancer R-HSA-4791275 0.593032 0.227 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.593461 0.227 0 0
Regulation of beta-cell development R-HSA-186712 0.593461 0.227 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.598427 0.223 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.603273 0.219 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.608814 0.216 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.608814 0.216 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.608814 0.216 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.608814 0.216 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.608814 0.216 0 0
Transmission across Chemical Synapses R-HSA-112315 0.610292 0.214 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.611269 0.214 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.612349 0.213 1 1
Protein lipoylation R-HSA-9857492 0.612349 0.213 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.612349 0.213 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.612349 0.213 0 0
FGFR3 ligand binding and activation R-HSA-190239 0.612349 0.213 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.612349 0.213 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.612349 0.213 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.612349 0.213 0 0
Formation of the anterior neural plate R-HSA-9823739 0.612349 0.213 0 0
DNA Damage Reversal R-HSA-73942 0.612349 0.213 0 0
G-protein beta:gamma signalling R-HSA-397795 0.613262 0.212 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.613262 0.212 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.613262 0.212 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.613262 0.212 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.615451 0.211 0 0
Signaling by Hedgehog R-HSA-5358351 0.617839 0.209 0 0
Signaling by MET R-HSA-6806834 0.618472 0.209 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.623853 0.205 0 0
Aquaporin-mediated transport R-HSA-445717 0.623853 0.205 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.624700 0.204 0 0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656244 0.624700 0.204 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.624700 0.204 0 0
Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656243 0.624700 0.204 0 0
Defective CHST6 causes MCDC1 R-HSA-3656225 0.624700 0.204 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 0.624700 0.204 0 0
CREB phosphorylation R-HSA-199920 0.624700 0.204 1 1
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 0.624700 0.204 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 0.624700 0.204 0 0
Neurofascin interactions R-HSA-447043 0.624700 0.204 0 0
NADPH regeneration R-HSA-389542 0.624700 0.204 0 0
Lipid particle organization R-HSA-8964572 0.624700 0.204 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.627739 0.202 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.627739 0.202 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.627739 0.202 0 0
MHC class II antigen presentation R-HSA-2132295 0.629310 0.201 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.632856 0.199 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.633910 0.198 0 0
Interleukin-6 family signaling R-HSA-6783589 0.633910 0.198 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.635964 0.197 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.635964 0.197 0 0
tRNA processing in the nucleus R-HSA-6784531 0.638566 0.195 0 0
Host Interactions of HIV factors R-HSA-162909 0.639800 0.194 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.640026 0.194 0 0
Killing mechanisms R-HSA-9664420 0.640026 0.194 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.640026 0.194 0 0
Phase 4 - resting membrane potential R-HSA-5576886 0.640026 0.194 0 0
Regulation of BACH1 activity R-HSA-9708530 0.640026 0.194 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.640026 0.194 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.640026 0.194 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 0.640026 0.194 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.641462 0.193 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.651495 0.186 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.651495 0.186 0 0
Dual Incision in GG-NER R-HSA-5696400 0.651798 0.186 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.651798 0.186 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.651798 0.186 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.654014 0.184 0 0
Signaling by TGFB family members R-HSA-9006936 0.654638 0.184 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.654895 0.184 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.654895 0.184 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.655615 0.183 0 0
Tight junction interactions R-HSA-420029 0.655615 0.183 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.655615 0.183 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.655615 0.183 0 0
HDMs demethylate histones R-HSA-3214842 0.655615 0.183 0 0
Interleukin-7 signaling R-HSA-1266695 0.655615 0.183 0 0
Formation of the nephric duct R-HSA-9830364 0.655615 0.183 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.657179 0.182 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.657179 0.182 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.659632 0.181 0 0
G1/S Transition R-HSA-69206 0.660316 0.180 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 0.663432 0.178 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.663432 0.178 0 0
Netrin mediated repulsion signals R-HSA-418886 0.663432 0.178 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.663432 0.178 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.663432 0.178 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.663432 0.178 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 0.663432 0.178 0 0
FGFR3b ligand binding and activation R-HSA-190371 0.663432 0.178 0 0
PTK6 Expression R-HSA-8849473 0.663432 0.178 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 0.663432 0.178 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 0.663432 0.178 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.663432 0.178 0 0
VLDL clearance R-HSA-8964046 0.663432 0.178 0 0
Glycoprotein hormones R-HSA-209822 0.663432 0.178 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 0.663432 0.178 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 0.663432 0.178 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 0.663432 0.178 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.663432 0.178 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.666122 0.176 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.666122 0.176 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.666122 0.176 0 0
Disorders of Developmental Biology R-HSA-9675151 0.666122 0.176 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.666614 0.176 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.667384 0.176 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.671369 0.173 0 0
Signaling by Insulin receptor R-HSA-74752 0.671369 0.173 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.673400 0.172 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.675575 0.170 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.675575 0.170 1 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.676379 0.170 0 0
Metalloprotease DUBs R-HSA-5689901 0.676379 0.170 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.676379 0.170 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.676379 0.170 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.681312 0.167 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.681312 0.167 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.683352 0.165 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.683352 0.165 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.687385 0.163 0 0
G1/S-Specific Transcription R-HSA-69205 0.687680 0.163 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.687680 0.163 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 0.690668 0.161 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.690668 0.161 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.690668 0.161 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.690668 0.161 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.690668 0.161 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.690668 0.161 0 0
Integration of energy metabolism R-HSA-163685 0.691898 0.160 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.693497 0.159 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.695581 0.158 0 0
Signaling by FGFR1 R-HSA-5654736 0.695581 0.158 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.695581 0.158 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.696118 0.157 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.696202 0.157 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.696202 0.157 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.696202 0.157 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.696202 0.157 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.696355 0.157 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 0.698169 0.156 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.698169 0.156 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.698169 0.156 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.698169 0.156 0 0
Activation of RAS in B cells R-HSA-1169092 0.698169 0.156 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 0.698169 0.156 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.698169 0.156 0 0
Regulation by c-FLIP R-HSA-3371378 0.698169 0.156 0 0
Co-stimulation by ICOS R-HSA-9927354 0.698169 0.156 0 0
Interleukin-9 signaling R-HSA-8985947 0.698169 0.156 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 0.698169 0.156 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 0.698169 0.156 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 0.698169 0.156 0 0
Dimerization of procaspase-8 R-HSA-69416 0.698169 0.156 0 0
Nucleotide salvage defects R-HSA-9734207 0.698169 0.156 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 0.698169 0.156 0 0
RSK activation R-HSA-444257 0.698169 0.156 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.698169 0.156 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.698795 0.156 0 0
Diseases of DNA repair R-HSA-9675135 0.698795 0.156 0 0
Muscle contraction R-HSA-397014 0.701770 0.154 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.704610 0.152 0 0
Degradation of DVL R-HSA-4641258 0.704610 0.152 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.704610 0.152 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.706417 0.151 0 0
Regulation of CDH1 Function R-HSA-9764561 0.709419 0.149 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.711573 0.148 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.713705 0.146 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.713705 0.146 0 0
Mismatch Repair R-HSA-5358508 0.713705 0.146 0 0
Platelet sensitization by LDL R-HSA-432142 0.713705 0.146 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.713705 0.146 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 0.713705 0.146 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.713710 0.146 0 0
Inflammasomes R-HSA-622312 0.715091 0.146 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.715869 0.145 0 0
Developmental Cell Lineages R-HSA-9734767 0.719854 0.143 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.725943 0.139 1 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.726363 0.139 0 0
Peptide chain elongation R-HSA-156902 0.727326 0.138 0 0
Metal ion SLC transporters R-HSA-425410 0.728094 0.138 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 0.729323 0.137 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 0.729323 0.137 0 0
CASP8 activity is inhibited R-HSA-5218900 0.729323 0.137 0 0
ALK mutants bind TKIs R-HSA-9700645 0.729323 0.137 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.729323 0.137 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.729323 0.137 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.729323 0.137 0 0
Unwinding of DNA R-HSA-176974 0.729323 0.137 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.729323 0.137 0 0
Interleukin-1 processing R-HSA-448706 0.729323 0.137 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 0.729323 0.137 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.729323 0.137 0 0
Signaling by Erythropoietin R-HSA-9006335 0.733057 0.135 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.735285 0.134 0 0
Other interleukin signaling R-HSA-449836 0.735285 0.134 0 0
Extension of Telomeres R-HSA-180786 0.735784 0.133 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.735784 0.133 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.736446 0.133 0 0
Influenza Infection R-HSA-168255 0.739589 0.131 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.739953 0.131 0 0
Signaling by FGFR2 R-HSA-5654738 0.740247 0.131 0 0
Ion channel transport R-HSA-983712 0.740720 0.130 0 0
DNA Damage Bypass R-HSA-73893 0.741949 0.130 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.743531 0.129 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.744856 0.128 0 0
Synthesis of DNA R-HSA-69239 0.745345 0.128 0 0
Signaling by ERBB2 R-HSA-1227986 0.748311 0.126 0 0
DAP12 signaling R-HSA-2424491 0.750117 0.125 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.750117 0.125 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.750117 0.125 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.750117 0.125 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.751155 0.124 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.751362 0.124 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.751362 0.124 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.751362 0.124 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.751362 0.124 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.752596 0.123 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.752775 0.123 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.755277 0.122 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 0.755462 0.122 0 0
Signal transduction by L1 R-HSA-445144 0.755462 0.122 0 0
Nephrin family interactions R-HSA-373753 0.755462 0.122 0 0
MAPK3 (ERK1) activation R-HSA-110056 0.757262 0.121 0 0
DNA replication initiation R-HSA-68952 0.757262 0.121 0 0
PI3K/AKT activation R-HSA-198203 0.757262 0.121 0 0
2-LTR circle formation R-HSA-164843 0.757262 0.121 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.757262 0.121 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 0.757262 0.121 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.757262 0.121 0 0
Arachidonate production from DAG R-HSA-426048 0.757262 0.121 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.757262 0.121 0 0
Interleukin-27 signaling R-HSA-9020956 0.757262 0.121 0 0
Maturation of spike protein R-HSA-9683686 0.757262 0.121 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 0.757262 0.121 0 0
Peptide hormone biosynthesis R-HSA-209952 0.757262 0.121 0 0
Regulation of the apoptosome activity R-HSA-9627069 0.757262 0.121 0 0
Signaling by Leptin R-HSA-2586552 0.757262 0.121 0 0
Formation of apoptosome R-HSA-111458 0.757262 0.121 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.758573 0.120 0 0
MAP kinase activation R-HSA-450294 0.760402 0.119 1 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.765620 0.116 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.766082 0.116 1 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.766291 0.116 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.766291 0.116 0 0
Budding and maturation of HIV virion R-HSA-162588 0.766291 0.116 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.766291 0.116 0 0
Adaptive Immune System R-HSA-1280218 0.766915 0.115 0 0
IRE1alpha activates chaperones R-HSA-381070 0.768411 0.114 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.772060 0.112 0 0
Signaling by PDGF R-HSA-186797 0.772060 0.112 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.774295 0.111 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.774295 0.111 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.774295 0.111 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.774295 0.111 0 0
Basigin interactions R-HSA-210991 0.774295 0.111 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.774295 0.111 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.774295 0.111 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.779232 0.108 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.779232 0.108 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.779232 0.108 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.780373 0.108 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.781601 0.107 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.782319 0.107 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 0.782319 0.107 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.782319 0.107 0 0
vRNA Synthesis R-HSA-192814 0.782319 0.107 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 0.782319 0.107 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 0.782319 0.107 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 0.782319 0.107 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 0.782319 0.107 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 0.782319 0.107 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 0.782319 0.107 0 0
Transport of RCbl within the body R-HSA-9758890 0.782319 0.107 0 0
Dissolution of Fibrin Clot R-HSA-75205 0.782319 0.107 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.783288 0.106 0 0
Signaling by ERBB4 R-HSA-1236394 0.787154 0.104 0 0
HCMV Late Events R-HSA-9610379 0.789917 0.102 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 0.791848 0.101 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.791848 0.101 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.791848 0.101 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.791848 0.101 0 0
Assembly Of The HIV Virion R-HSA-175474 0.791848 0.101 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.795413 0.099 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.796074 0.099 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.796074 0.099 0 0
Cardiogenesis R-HSA-9733709 0.796074 0.099 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.797141 0.098 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 0.804791 0.094 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.804791 0.094 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.804791 0.094 0 0
NF-kB is activated and signals survival R-HSA-209560 0.804791 0.094 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.804791 0.094 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 0.804791 0.094 0 0
Integration of provirus R-HSA-162592 0.804791 0.094 0 0
Gastrulation R-HSA-9758941 0.804837 0.094 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.804890 0.094 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.804890 0.094 0 0
LDL clearance R-HSA-8964038 0.808183 0.092 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 0.808183 0.092 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 0.808183 0.092 0 0
Cardiac conduction R-HSA-5576891 0.808267 0.092 0 0
Striated Muscle Contraction R-HSA-390522 0.809735 0.092 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.809810 0.092 0 0
Eukaryotic Translation Termination R-HSA-72764 0.813302 0.090 0 0
Signaling by NOTCH3 R-HSA-9012852 0.814226 0.089 0 0
Circadian clock R-HSA-9909396 0.815371 0.089 0 0
Signaling by NOTCH R-HSA-157118 0.817530 0.087 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.820982 0.086 1 0
Potassium Channels R-HSA-1296071 0.821437 0.085 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.823366 0.084 0 0
Carnitine shuttle R-HSA-200425 0.823366 0.084 0 0
Growth hormone receptor signaling R-HSA-982772 0.823366 0.084 0 0
Syndecan interactions R-HSA-3000170 0.823366 0.084 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.824537 0.084 0 0
IRAK1 recruits IKK complex R-HSA-937039 0.824945 0.084 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 0.824945 0.084 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.824945 0.084 0 0
Regulation of IFNG signaling R-HSA-877312 0.824945 0.084 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 0.824945 0.084 0 0
VLDLR internalisation and degradation R-HSA-8866427 0.824945 0.084 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 0.824945 0.084 0 0
Interleukin-35 Signalling R-HSA-8984722 0.824945 0.084 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.824945 0.084 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 0.824945 0.084 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 0.824945 0.084 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 0.824945 0.084 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 0.824945 0.084 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.824945 0.084 0 0
Pervasive developmental disorders R-HSA-9005895 0.824945 0.084 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.824945 0.084 0 0
Disorders of Nervous System Development R-HSA-9697154 0.824945 0.084 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 0.824945 0.084 0 0
Estrogen biosynthesis R-HSA-193144 0.824945 0.084 0 0
PCP/CE pathway R-HSA-4086400 0.824966 0.084 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.825371 0.083 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.827485 0.082 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.832146 0.080 0 0
Regulation of Apoptosis R-HSA-169911 0.834743 0.078 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.834743 0.078 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.834743 0.078 0 0
Regulation of insulin secretion R-HSA-422356 0.836888 0.077 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.837459 0.077 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.837459 0.077 0 0
Complex III assembly R-HSA-9865881 0.837459 0.077 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.838081 0.077 1 1
Signaling by TGFBR3 R-HSA-9839373 0.838081 0.077 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.839319 0.076 1 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.841789 0.075 0 0
FGFR4 ligand binding and activation R-HSA-190322 0.843018 0.074 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.843018 0.074 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.843018 0.074 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.843018 0.074 0 0
Diseases of nucleotide metabolism R-HSA-9735804 0.843018 0.074 0 0
rRNA modification in the mitochondrion R-HSA-6793080 0.843018 0.074 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 0.843018 0.074 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 0.843018 0.074 0 0
Maturation of nucleoprotein R-HSA-9683610 0.843018 0.074 0 0
Dual incision in TC-NER R-HSA-6782135 0.843766 0.074 0 0
HSF1 activation R-HSA-3371511 0.846150 0.073 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.846252 0.073 1 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.850380 0.070 0 0
Interleukin-17 signaling R-HSA-448424 0.850380 0.070 1 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.850527 0.070 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.850527 0.070 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.850527 0.070 0 0
Laminin interactions R-HSA-3000157 0.850527 0.070 0 0
NCAM1 interactions R-HSA-419037 0.856866 0.067 0 0
Collagen chain trimerization R-HSA-8948216 0.856866 0.067 0 0
Selenocysteine synthesis R-HSA-2408557 0.858083 0.066 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.858286 0.066 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.859227 0.066 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.859227 0.066 0 0
FGFR3c ligand binding and activation R-HSA-190372 0.859227 0.066 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 0.859227 0.066 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.859227 0.066 0 0
Physiological factors R-HSA-5578768 0.859227 0.066 0 0
Glycerophospholipid catabolism R-HSA-6814848 0.859227 0.066 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 0.859227 0.066 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.859227 0.066 0 0
Kinesins R-HSA-983189 0.861221 0.065 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.862294 0.064 1 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.862630 0.064 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.862630 0.064 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.862630 0.064 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.862630 0.064 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.864570 0.063 0 0
PTEN Regulation R-HSA-6807070 0.865314 0.063 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.866922 0.062 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.866922 0.062 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.869318 0.061 0 0
Viral mRNA Translation R-HSA-192823 0.870948 0.060 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.871662 0.060 1 0
Potential therapeutics for SARS R-HSA-9679191 0.872826 0.059 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.873763 0.059 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.873763 0.059 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 0.873763 0.059 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.873763 0.059 0 0
Translesion synthesis by REV1 R-HSA-110312 0.873763 0.059 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.873763 0.059 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.873763 0.059 0 0
p75NTR signals via NF-kB R-HSA-193639 0.873763 0.059 0 0
Erythropoietin activates RAS R-HSA-9027284 0.873763 0.059 0 0
p38MAPK events R-HSA-171007 0.873763 0.059 1 1
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.873763 0.059 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.873763 0.059 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.873763 0.059 1 1
IRF3-mediated induction of type I IFN R-HSA-3270619 0.873763 0.059 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.873763 0.059 0 0
Other semaphorin interactions R-HSA-416700 0.873763 0.059 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.873763 0.059 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.873828 0.059 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 0.873828 0.059 0 0
Insulin processing R-HSA-264876 0.873828 0.059 0 0
Adipogenesis R-HSA-9843745 0.874274 0.058 0 0
Developmental Biology R-HSA-1266738 0.875120 0.058 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.875975 0.058 0 0
Stabilization of p53 R-HSA-69541 0.876350 0.057 0 0
Signaling by ALK R-HSA-201556 0.876350 0.057 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.876350 0.057 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.877017 0.057 0 0
Collagen formation R-HSA-1474290 0.877191 0.057 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.879571 0.056 0 0
Signaling by NOTCH4 R-HSA-9013694 0.880411 0.055 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.882679 0.054 0 0
RSV-host interactions R-HSA-9833110 0.882851 0.054 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.883179 0.054 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.884179 0.053 0 0
Telomere Extension By Telomerase R-HSA-171319 0.884179 0.053 0 0
Diseases of Immune System R-HSA-5260271 0.885181 0.053 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.885181 0.053 0 0
Translesion synthesis by POLI R-HSA-5656121 0.886799 0.052 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 0.886799 0.052 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 0.886799 0.052 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 0.886799 0.052 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.886799 0.052 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 0.886799 0.052 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.886799 0.052 0 0
Differentiation of T cells R-HSA-9945266 0.886799 0.052 0 0
Negative regulation of FLT3 R-HSA-9706369 0.886799 0.052 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 0.886799 0.052 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 0.886799 0.052 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.887072 0.052 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.888406 0.051 0 0
Orc1 removal from chromatin R-HSA-68949 0.890759 0.050 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.890759 0.050 0 0
Ion transport by P-type ATPases R-HSA-936837 0.891245 0.050 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.893443 0.049 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.893443 0.049 0 0
Maturation of spike protein R-HSA-9694548 0.893443 0.049 0 0
mRNA Capping R-HSA-72086 0.893738 0.049 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.893738 0.049 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.893835 0.049 0 0
HCMV Early Events R-HSA-9609690 0.894433 0.048 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.894742 0.048 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.897904 0.047 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.897904 0.047 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.898489 0.046 0 0
Translesion synthesis by POLK R-HSA-5655862 0.898489 0.046 0 0
Glycine degradation R-HSA-6783984 0.898489 0.046 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 0.898489 0.046 0 0
Phase 2 - plateau phase R-HSA-5576893 0.898489 0.046 0 0
Coenzyme A biosynthesis R-HSA-196783 0.898489 0.046 0 0
tRNA modification in the mitochondrion R-HSA-6787450 0.898489 0.046 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 0.898489 0.046 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.899454 0.046 0 0
Vesicle-mediated transport R-HSA-5653656 0.899831 0.046 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.901168 0.045 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.901168 0.045 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 0.901168 0.045 0 0
Activation of the pre-replicative complex R-HSA-68962 0.902560 0.045 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.902560 0.045 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.904035 0.044 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.904350 0.044 0 0
Translation initiation complex formation R-HSA-72649 0.904634 0.044 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.905234 0.043 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.905234 0.043 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.905234 0.043 1 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.907679 0.042 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.908384 0.042 0 0
Activation of GABAB receptors R-HSA-991365 0.908384 0.042 0 0
GABA B receptor activation R-HSA-977444 0.908384 0.042 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.908973 0.041 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 0.908973 0.041 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 0.908973 0.041 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.908973 0.041 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.908973 0.041 0 0
Sulfide oxidation to sulfate R-HSA-1614517 0.908973 0.041 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 0.908973 0.041 0 0
Catecholamine biosynthesis R-HSA-209905 0.908973 0.041 0 0
GDP-fucose biosynthesis R-HSA-6787639 0.908973 0.041 0 0
Choline catabolism R-HSA-6798163 0.908973 0.041 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.908973 0.041 0 0
Cargo concentration in the ER R-HSA-5694530 0.910693 0.041 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.915118 0.039 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.915742 0.038 0 0
PKR-mediated signaling R-HSA-9833482 0.915834 0.038 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.916806 0.038 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.916925 0.038 0 0
TNF signaling R-HSA-75893 0.916925 0.038 1 0
Inwardly rectifying K+ channels R-HSA-1296065 0.918186 0.037 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.918186 0.037 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 0.918374 0.037 0 0
Presynaptic function of Kainate receptors R-HSA-500657 0.918374 0.037 0 0
Apoptotic factor-mediated response R-HSA-111471 0.918374 0.037 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 0.918374 0.037 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 0.918374 0.037 0 0
Tie2 Signaling R-HSA-210993 0.918374 0.037 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 0.918374 0.037 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 0.918374 0.037 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.919547 0.036 0 0
Leishmania phagocytosis R-HSA-9664417 0.919547 0.036 0 0
Parasite infection R-HSA-9664407 0.919547 0.036 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.919548 0.036 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.920589 0.036 1 0
DAP12 interactions R-HSA-2172127 0.921399 0.036 0 0
Defective B3GALTL causes PpS R-HSA-5083635 0.925085 0.034 0 0
Recycling of bile acids and salts R-HSA-159418 0.925085 0.034 0 0
Interleukin-1 family signaling R-HSA-446652 0.926511 0.033 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 0.926805 0.033 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.926805 0.033 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.926805 0.033 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 0.926805 0.033 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 0.926805 0.033 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.926805 0.033 0 0
Maturation of nucleoprotein R-HSA-9694631 0.926805 0.033 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 0.926805 0.033 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.927252 0.033 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.927252 0.033 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.927252 0.033 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.927252 0.033 0 0
Somitogenesis R-HSA-9824272 0.927252 0.033 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.927779 0.033 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.927779 0.033 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.929839 0.032 0 0
Hedgehog 'on' state R-HSA-5632684 0.930423 0.031 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.931432 0.031 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.931432 0.031 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.931432 0.031 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 0.931432 0.031 0 0
Parasitic Infection Pathways R-HSA-9824443 0.932630 0.030 0 0
Leishmania infection R-HSA-9658195 0.932630 0.030 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.932701 0.030 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.932701 0.030 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.932701 0.030 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.932701 0.030 0 0
Mitochondrial protein degradation R-HSA-9837999 0.934281 0.030 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.934366 0.029 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 0.934366 0.029 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.934366 0.029 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.934366 0.029 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.934366 0.029 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 0.934366 0.029 0 0
Pregnenolone biosynthesis R-HSA-196108 0.934366 0.029 0 0
Keratan sulfate degradation R-HSA-2022857 0.934366 0.029 0 0
Formation of definitive endoderm R-HSA-9823730 0.934366 0.029 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.934366 0.029 0 0
Protein hydroxylation R-HSA-9629569 0.934366 0.029 0 0
Signaling by NODAL R-HSA-1181150 0.934366 0.029 0 0
PPARA activates gene expression R-HSA-1989781 0.935993 0.029 0 0
eNOS activation R-HSA-203615 0.937268 0.028 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.937268 0.028 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.937268 0.028 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.937268 0.028 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.937268 0.028 0 0
Mitophagy R-HSA-5205647 0.937268 0.028 0 0
GABA receptor activation R-HSA-977443 0.937337 0.028 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.937337 0.028 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.937773 0.028 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.937773 0.028 0 0
Phospholipid metabolism R-HSA-1483257 0.940445 0.027 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.941146 0.026 0 0
G-protein activation R-HSA-202040 0.941146 0.026 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 0.941146 0.026 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.941146 0.026 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 0.941146 0.026 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.941146 0.026 0 0
Phenylalanine metabolism R-HSA-8964208 0.941146 0.026 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 0.941146 0.026 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.941392 0.026 0 0
Collagen degradation R-HSA-1442490 0.941672 0.026 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.941715 0.026 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.941745 0.026 0 0
Intraflagellar transport R-HSA-5620924 0.942489 0.026 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.942489 0.026 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.942630 0.026 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.942630 0.026 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.943214 0.025 0 0
Cellular response to starvation R-HSA-9711097 0.944407 0.025 0 0
Mitochondrial protein import R-HSA-1268020 0.945731 0.024 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.945731 0.024 0 0
Toll-like Receptor Cascades R-HSA-168898 0.946147 0.024 1 0
Gap junction trafficking and regulation R-HSA-157858 0.946871 0.024 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.947226 0.024 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 0.947226 0.024 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.947226 0.024 1 1
Attachment and Entry R-HSA-9694614 0.947226 0.024 0 0
Glutathione synthesis and recycling R-HSA-174403 0.947226 0.024 0 0
Glycosphingolipid transport R-HSA-9845576 0.947554 0.023 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.947554 0.023 0 0
Triglyceride catabolism R-HSA-163560 0.947554 0.023 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.947554 0.023 0 0
Ribosome-associated quality control R-HSA-9948299 0.948692 0.023 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.951185 0.022 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.951282 0.022 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.951756 0.021 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.951756 0.021 1 0
Neutrophil degranulation R-HSA-6798695 0.952014 0.021 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 0.952074 0.021 0 0
Degradation of AXIN R-HSA-4641257 0.952074 0.021 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.952074 0.021 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.952678 0.021 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 0.952678 0.021 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.952678 0.021 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 0.952678 0.021 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.953084 0.021 0 0
Cellular response to hypoxia R-HSA-1234174 0.956406 0.019 0 0
HCMV Infection R-HSA-9609646 0.956987 0.019 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.957567 0.019 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.957567 0.019 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.957567 0.019 0 0
Termination of O-glycan biosynthesis R-HSA-977068 0.957567 0.019 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.957567 0.019 0 0
Interleukin-20 family signaling R-HSA-8854691 0.957567 0.019 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 0.957567 0.019 0 0
Organic anion transport by SLCO transporters R-HSA-879518 0.957567 0.019 0 0
Biosynthesis of maresins R-HSA-9018682 0.957567 0.019 0 0
Downstream TCR signaling R-HSA-202424 0.957623 0.019 0 0
Neurotransmitter release cycle R-HSA-112310 0.957623 0.019 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.959200 0.018 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.959200 0.018 1 0
Interleukin-1 signaling R-HSA-9020702 0.959351 0.018 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.960020 0.018 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.960020 0.018 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 0.961952 0.017 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.961952 0.017 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 0.961952 0.017 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.961952 0.017 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.963504 0.016 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.963504 0.016 0 0
Formation of the cornified envelope R-HSA-6809371 0.963575 0.016 0 0
Neddylation R-HSA-8951664 0.963615 0.016 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.964480 0.016 0 0
Regulated Necrosis R-HSA-5218859 0.965112 0.015 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.965112 0.015 0 0
Hyaluronan degradation R-HSA-2160916 0.965883 0.015 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 0.965883 0.015 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.965883 0.015 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.965883 0.015 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 0.966694 0.015 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.966694 0.015 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.966694 0.015 0 0
Paracetamol ADME R-HSA-9753281 0.967267 0.014 0 0
G alpha (z) signalling events R-HSA-418597 0.967267 0.014 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.967327 0.014 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.967377 0.014 0 0
Cellular response to chemical stress R-HSA-9711123 0.967874 0.014 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.968532 0.014 0 0
MET activates PTK2 signaling R-HSA-8874081 0.969409 0.013 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.969409 0.013 0 0
Sphingolipid catabolism R-HSA-9845614 0.969409 0.013 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.969615 0.013 0 0
Intra-Golgi traffic R-HSA-6811438 0.969615 0.013 0 0
Translation of Structural Proteins R-HSA-9683701 0.969615 0.013 0 0
Metabolism of amine-derived hormones R-HSA-209776 0.969847 0.013 0 0
Platelet homeostasis R-HSA-418346 0.972087 0.012 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.972177 0.012 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.972570 0.012 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.972570 0.012 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 0.972570 0.012 0 0
Triglyceride biosynthesis R-HSA-75109 0.972570 0.012 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 0.972570 0.012 0 0
Signaling by BMP R-HSA-201451 0.972570 0.012 0 0
Maturation of hRSV A proteins R-HSA-9828806 0.972570 0.012 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.974440 0.011 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.975032 0.011 0 0
Insulin receptor recycling R-HSA-77387 0.975405 0.011 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.975405 0.011 0 0
Pyrimidine salvage R-HSA-73614 0.975405 0.011 0 0
Pyroptosis R-HSA-5620971 0.975405 0.011 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.975405 0.011 0 0
Ca2+ pathway R-HSA-4086398 0.976117 0.010 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.976195 0.010 0 0
Triglyceride metabolism R-HSA-8979227 0.976479 0.010 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.976955 0.010 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 0.976970 0.010 1 1
Gap junction trafficking R-HSA-190828 0.976970 0.010 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.977409 0.010 0 0
Platelet calcium homeostasis R-HSA-418360 0.977947 0.010 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 0.977947 0.010 0 0
rRNA processing R-HSA-72312 0.977948 0.010 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.978363 0.009 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 0.979527 0.009 0 0
Neurotransmitter clearance R-HSA-112311 0.980226 0.009 0 0
ABC-family proteins mediated transport R-HSA-382556 0.980995 0.008 0 0
ER-Phagosome pathway R-HSA-1236974 0.981391 0.008 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 0.982270 0.008 0 0
Translation of Structural Proteins R-HSA-9694635 0.982475 0.008 0 0
ABC transporter disorders R-HSA-5619084 0.983793 0.007 0 0
Integrin cell surface interactions R-HSA-216083 0.983793 0.007 0 0
DAG1 glycosylations R-HSA-8931838 0.984103 0.007 0 0
Gluconeogenesis R-HSA-70263 0.984146 0.007 0 0
Interferon Signaling R-HSA-913531 0.984273 0.007 0 0
tRNA processing R-HSA-72306 0.984417 0.007 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.984471 0.007 0 0
Interferon gamma signaling R-HSA-877300 0.984487 0.007 0 0
G alpha (s) signalling events R-HSA-418555 0.985264 0.006 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.985615 0.006 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.985747 0.006 0 0
Keratan sulfate biosynthesis R-HSA-2022854 0.985747 0.006 0 0
Interferon alpha/beta signaling R-HSA-909733 0.986415 0.006 0 0
Platelet degranulation R-HSA-114608 0.986511 0.006 0 0
Azathioprine ADME R-HSA-9748787 0.986865 0.006 0 0
Glutamate and glutamine metabolism R-HSA-8964539 0.987220 0.006 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.987220 0.006 0 0
Heme degradation R-HSA-189483 0.987220 0.006 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.988048 0.005 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.988048 0.005 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.988541 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 0.988541 0.005 0 0
Signaling by NOTCH2 R-HSA-1980145 0.988541 0.005 0 0
RA biosynthesis pathway R-HSA-5365859 0.988541 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.988541 0.005 0 0
Calnexin/calreticulin cycle R-HSA-901042 0.988541 0.005 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.989128 0.005 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.989189 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.989726 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 0.989726 0.004 0 0
PERK regulates gene expression R-HSA-381042 0.989726 0.004 0 0
Nucleotide biosynthesis R-HSA-8956320 0.990112 0.004 0 0
SLC transporter disorders R-HSA-5619102 0.990285 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 0.990768 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.990789 0.004 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.991467 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.991535 0.004 0 0
Metabolism of cofactors R-HSA-8978934 0.991535 0.004 0 0
Voltage gated Potassium channels R-HSA-1296072 0.991741 0.004 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 0.991741 0.004 0 0
SLC-mediated transport of organic cations R-HSA-549127 0.991741 0.004 0 0
Lysine catabolism R-HSA-71064 0.991741 0.004 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.992570 0.003 0 0
Purine salvage R-HSA-74217 0.992595 0.003 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.992708 0.003 0 0
Dectin-2 family R-HSA-5621480 0.993248 0.003 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 0.993361 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 0.994048 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 0.994048 0.003 0 0
Selenoamino acid metabolism R-HSA-2408522 0.994626 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 0.994663 0.002 0 0
Metabolism of polyamines R-HSA-351202 0.994938 0.002 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.995103 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.995215 0.002 0 0
Endogenous sterols R-HSA-211976 0.995403 0.002 0 0
Nucleotide salvage R-HSA-8956321 0.995403 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 0.995418 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.995543 0.002 0 0
Protein folding R-HSA-391251 0.995543 0.002 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.995710 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.995710 0.002 0 0
Pyrimidine catabolism R-HSA-73621 0.996154 0.002 0 0
Complex I biogenesis R-HSA-6799198 0.996211 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.996513 0.002 0 0
RMTs methylate histone arginines R-HSA-3214858 0.996552 0.002 0 0
Surfactant metabolism R-HSA-5683826 0.996552 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.996552 0.002 0 0
SARS-CoV Infections R-HSA-9679506 0.996869 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 0.996909 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 0.996909 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.997024 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.997062 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.997229 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 0.997431 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 0.997670 0.001 0 0
Viral Infection Pathways R-HSA-9824446 0.997691 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.997718 0.001 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 0.998003 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.998003 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 0.998003 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.998083 0.001 0 0
ECM proteoglycans R-HSA-3000178 0.998262 0.001 0 0
Complex IV assembly R-HSA-9864848 0.998395 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.998562 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.998706 0.001 0 0
Iron uptake and transport R-HSA-917937 0.998827 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.998879 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.998879 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.999077 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.999128 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 0.999128 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.999210 0.000 0 0
Peroxisomal protein import R-HSA-9033241 0.999330 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.999330 0.000 0 0
Protein localization R-HSA-9609507 0.999351 0.000 0 0
tRNA Aminoacylation R-HSA-379724 0.999400 0.000 0 0
Glutathione conjugation R-HSA-156590 0.999400 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 0.999431 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.999558 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 0.999612 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999629 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.999644 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.999648 0.000 0 0
Pyruvate metabolism R-HSA-70268 0.999677 0.000 0 0
Nicotinate metabolism R-HSA-196807 0.999721 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.999721 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 0.999721 0.000 0 0
O-linked glycosylation R-HSA-5173105 0.999789 0.000 0 0
Metabolism of porphyrins R-HSA-189445 0.999820 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.999823 0.000 0 0
Purine catabolism R-HSA-74259 0.999838 0.000 0 0
Post-translational protein modification R-HSA-597592 0.999839 0.000 0 0
Aspirin ADME R-HSA-9749641 0.999855 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.999861 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999866 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 0.999893 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.999894 0.000 0 0
Keratinization R-HSA-6805567 0.999908 0.000 0 0
Immune System R-HSA-168256 0.999924 0.000 1 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 0.999925 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 0.999940 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.999947 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 0.999957 0.000 0 0
G alpha (i) signalling events R-HSA-418594 0.999960 0.000 0 0
Extracellular matrix organization R-HSA-1474244 0.999964 0.000 0 0
Hemostasis R-HSA-109582 0.999969 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 0.999969 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.999969 0.000 0 0
GPCR downstream signalling R-HSA-388396 0.999971 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 0.999974 0.000 0 0
FCGR activation R-HSA-2029481 0.999987 0.000 0 0
Mitochondrial translation R-HSA-5368287 0.999993 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 0.999997 0.000 0 0
Nucleotide catabolism R-HSA-8956319 0.999998 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 0.999998 0.000 0 0
Translation R-HSA-72766 0.999998 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.999999 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999999 0.000 0 0
Signaling by GPCR R-HSA-372790 0.999999 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.999999 0.000 0 0
Sphingolipid metabolism R-HSA-428157 0.999999 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999999 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000 0.000 0 0
Innate Immune System R-HSA-168249 1.000000 0.000 1 0
Arachidonate metabolism R-HSA-2142753 1.000000 0.000 1 0
Metabolism of nucleotides R-HSA-15869 1.000000 0.000 0 0
Drug ADME R-HSA-9748784 1.000000 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000 0.000 0 0
Disease R-HSA-1643685 1.000000 0.000 0 0
G alpha (q) signalling events R-HSA-416476 1.000000 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000 0.000 0 0
Infectious disease R-HSA-5663205 1.000000 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 1 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 -0.000 1 0
Olfactory Signaling Pathway R-HSA-381753 1.000000 -0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 1 0
GPCR ligand binding R-HSA-500792 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.293988e-10 9.639 0 0
Cell Cycle, Mitotic R-HSA-69278 3.907195e-10 9.408 0 0
Cellular response to heat stress R-HSA-3371556 1.121309e-09 8.950 1 0
M Phase R-HSA-68886 3.279492e-08 7.484 0 0
Recycling pathway of L1 R-HSA-437239 4.564726e-08 7.341 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.445562e-08 7.191 1 1
Mitotic Prometaphase R-HSA-68877 1.429069e-07 6.845 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.919268e-07 6.717 0 0
Mitotic Anaphase R-HSA-68882 4.504616e-07 6.346 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.054490e-07 6.296 0 0
Apoptotic execution phase R-HSA-75153 6.541061e-07 6.184 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.301375e-07 6.031 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.053736e-06 5.977 0 0
Signal Transduction R-HSA-162582 1.792686e-06 5.746 1 0
Post NMDA receptor activation events R-HSA-438064 2.859355e-06 5.544 0 0
L1CAM interactions R-HSA-373760 3.371251e-06 5.472 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.270448e-06 5.138 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.978183e-06 5.098 0 0
Axon guidance R-HSA-422475 7.845607e-06 5.105 0 0
Nervous system development R-HSA-9675108 8.658465e-06 5.063 0 0
Membrane Trafficking R-HSA-199991 1.050675e-05 4.979 0 0
Separation of Sister Chromatids R-HSA-2467813 1.102115e-05 4.958 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.125874e-05 4.949 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.494608e-05 4.825 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.543688e-05 4.811 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.763035e-05 4.754 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.811155e-05 4.742 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.965998e-05 4.706 0 0
Neurodegenerative Diseases R-HSA-8863678 2.129857e-05 4.672 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.129857e-05 4.672 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.261728e-05 4.646 0 0
Nuclear import of Rev protein R-HSA-180746 2.563624e-05 4.591 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.881084e-05 4.540 0 0
HSF1-dependent transactivation R-HSA-3371571 3.115970e-05 4.506 0 0
Signaling by Hippo R-HSA-2028269 3.564876e-05 4.448 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.266555e-05 4.278 0 0
Cellular responses to stress R-HSA-2262752 5.356452e-05 4.271 1 0
MTOR signalling R-HSA-165159 5.725034e-05 4.242 0 0
Activation of RAC1 R-HSA-428540 7.174241e-05 4.144 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.035556e-05 4.153 0 0
Cellular responses to stimuli R-HSA-8953897 8.229573e-05 4.085 1 0
Nuclear Envelope Breakdown R-HSA-2980766 9.948252e-05 4.002 0 0
Attenuation phase R-HSA-3371568 1.072604e-04 3.970 0 0
Aggrephagy R-HSA-9646399 1.072604e-04 3.970 0 0
Apoptosis R-HSA-109581 1.034866e-04 3.985 0 0
Chromatin organization R-HSA-4839726 1.088724e-04 3.963 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.179370e-04 3.928 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.513699e-04 3.820 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.513699e-04 3.820 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.605582e-04 3.794 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.648656e-04 3.783 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.012323e-04 3.696 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.169865e-04 3.664 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.430303e-04 3.614 0 0
mTORC1-mediated signalling R-HSA-166208 2.486159e-04 3.604 0 0
Gap junction trafficking and regulation R-HSA-157858 2.329432e-04 3.633 0 0
Chromatin modifying enzymes R-HSA-3247509 2.391859e-04 3.621 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.042799e-04 3.517 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.046844e-04 3.516 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.059348e-04 3.514 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.266274e-04 3.486 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.499129e-04 3.456 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.737346e-04 3.427 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.666089e-04 3.331 0 0
Formation of annular gap junctions R-HSA-196025 5.057171e-04 3.296 0 0
Kinesins R-HSA-983189 4.928764e-04 3.307 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.100508e-04 3.292 0 0
Mitotic Prophase R-HSA-68875 5.264327e-04 3.279 0 0
HSF1 activation R-HSA-3371511 5.719044e-04 3.243 0 0
Selective autophagy R-HSA-9663891 5.565499e-04 3.254 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.796121e-04 3.237 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.273285e-04 3.203 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.719440e-04 3.112 0 0
Gap junction degradation R-HSA-190873 7.916793e-04 3.101 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.992851e-04 3.046 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 9.181713e-04 3.037 0 0
Gap junction trafficking R-HSA-190828 9.359125e-04 3.029 0 0
Amplification of signal from the kinetochores R-HSA-141424 9.478286e-04 3.023 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 9.478286e-04 3.023 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.972279e-04 3.001 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.027302e-03 2.988 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.086284e-03 2.964 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.107710e-03 2.956 0 0
Cellular Senescence R-HSA-2559583 1.154732e-03 2.938 1 0
Signaling by NTRKs R-HSA-166520 1.153197e-03 2.938 1 0
PKR-mediated signaling R-HSA-9833482 1.117099e-03 2.952 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.188752e-03 2.925 0 0
Ephrin signaling R-HSA-3928664 1.189278e-03 2.925 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.189278e-03 2.925 0 0
Programmed Cell Death R-HSA-5357801 1.219232e-03 2.914 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.230358e-03 2.910 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.281735e-03 2.892 1 0
Signaling by ALK in cancer R-HSA-9700206 1.230358e-03 2.910 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.303862e-03 2.885 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.305058e-03 2.884 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.318888e-03 2.880 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.351456e-03 2.869 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.425169e-03 2.846 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.444358e-03 2.840 0 0
DCC mediated attractive signaling R-HSA-418885 1.721520e-03 2.764 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.763075e-03 2.754 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.647534e-03 2.783 0 0
G2/M Transition R-HSA-69275 1.824067e-03 2.739 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.036578e-03 2.691 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.144717e-03 2.669 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.234751e-03 2.651 0 0
Cell Cycle Checkpoints R-HSA-69620 2.307943e-03 2.637 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.483582e-03 2.605 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.541175e-03 2.595 1 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.862364e-03 2.543 0 0
Regulation of TP53 Activity R-HSA-5633007 3.049549e-03 2.516 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.215498e-03 2.493 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.314531e-03 2.480 0 0
Vesicle-mediated transport R-HSA-5653656 3.521075e-03 2.453 0 0
Signaling by ERBB2 R-HSA-1227986 3.555205e-03 2.449 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.555205e-03 2.449 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.830734e-03 2.417 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.898174e-03 2.409 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.525309e-03 2.344 0 0
Macroautophagy R-HSA-1632852 4.575722e-03 2.340 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.625753e-03 2.335 0 0
ALK mutants bind TKIs R-HSA-9700645 4.625753e-03 2.335 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.625753e-03 2.335 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.629001e-03 2.335 0 0
MAP2K and MAPK activation R-HSA-5674135 4.949982e-03 2.305 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.629408e-03 2.250 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.629408e-03 2.250 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.629408e-03 2.250 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.629408e-03 2.250 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.629408e-03 2.250 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.629408e-03 2.250 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.629408e-03 2.250 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.629408e-03 2.250 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.629408e-03 2.250 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.629408e-03 2.250 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.629408e-03 2.250 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.402945e-03 2.267 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.398251e-03 2.268 0 0
Semaphorin interactions R-HSA-373755 5.134783e-03 2.289 0 0
Signaling by PTK6 R-HSA-8848021 5.134783e-03 2.289 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.134783e-03 2.289 0 0
Glycolysis R-HSA-70171 5.679644e-03 2.246 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.864974e-03 2.232 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.955320e-03 2.225 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.427797e-03 2.192 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.611672e-03 2.180 0 0
Diseases of programmed cell death R-HSA-9645723 6.885633e-03 2.162 0 0
Host Interactions of HIV factors R-HSA-162909 6.879309e-03 2.162 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.236547e-03 2.140 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 7.465483e-03 2.127 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.500507e-03 2.125 1 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.516651e-03 2.124 0 0
G0 and Early G1 R-HSA-1538133 7.547915e-03 2.122 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.547915e-03 2.122 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.744498e-03 2.111 0 0
snRNP Assembly R-HSA-191859 7.752703e-03 2.111 0 0
Metabolism of non-coding RNA R-HSA-194441 7.752703e-03 2.111 0 0
Autophagy R-HSA-9612973 7.847665e-03 2.105 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.078449e-03 2.093 0 0
MAPK family signaling cascades R-HSA-5683057 8.567712e-03 2.067 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.443298e-03 2.025 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.185038e-03 2.037 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.789790e-03 2.009 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.789790e-03 2.009 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.789790e-03 2.009 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.837951e-03 2.054 0 0
Signaling by RAS mutants R-HSA-6802949 9.789790e-03 2.009 0 0
ESR-mediated signaling R-HSA-8939211 9.220081e-03 2.035 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.718522e-03 2.012 0 0
Developmental Biology R-HSA-1266738 8.874152e-03 2.052 0 0
tRNA processing in the nucleus R-HSA-6784531 1.083725e-02 1.965 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.140717e-02 1.943 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.176882e-02 1.929 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.176882e-02 1.929 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.205352e-02 1.919 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.205352e-02 1.919 0 0
NGF-stimulated transcription R-HSA-9031628 1.251823e-02 1.902 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.265538e-02 1.898 1 1
Signaling by EGFR R-HSA-177929 1.307944e-02 1.883 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.322521e-02 1.879 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.345836e-02 1.871 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.384992e-02 1.859 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.384992e-02 1.859 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.384992e-02 1.859 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.384992e-02 1.859 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.384992e-02 1.859 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.398077e-02 1.854 0 0
Regulation of gap junction activity R-HSA-191650 1.669814e-02 1.777 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.669814e-02 1.777 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.467678e-02 1.833 0 0
S Phase R-HSA-69242 1.474851e-02 1.831 0 0
HIV Life Cycle R-HSA-162587 1.486251e-02 1.828 0 0
Signaling by ROBO receptors R-HSA-376176 1.647640e-02 1.783 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.673429e-02 1.776 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.703381e-02 1.769 0 0
Type I hemidesmosome assembly R-HSA-446107 1.720337e-02 1.764 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.720337e-02 1.764 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.720337e-02 1.764 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.757656e-02 1.755 0 0
Polo-like kinase mediated events R-HSA-156711 1.757656e-02 1.755 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.757656e-02 1.755 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.770045e-02 1.752 0 0
Cell-Cell communication R-HSA-1500931 1.770681e-02 1.752 0 0
HCMV Early Events R-HSA-9609690 1.852089e-02 1.732 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.852112e-02 1.732 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.857949e-02 1.731 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.861984e-02 1.730 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.904302e-02 1.720 0 0
G2 Phase R-HSA-68911 2.487011e-02 1.604 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.487011e-02 1.604 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.297526e-02 1.639 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.297526e-02 1.639 0 0
EPH-Ephrin signaling R-HSA-2682334 2.168471e-02 1.664 0 0
TGFBR3 expression R-HSA-9839394 2.176554e-02 1.662 0 0
Integrin signaling R-HSA-354192 2.439386e-02 1.613 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.276680e-02 1.643 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.439386e-02 1.613 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.439386e-02 1.613 0 0
HDMs demethylate histones R-HSA-3214842 2.176554e-02 1.662 0 0
MHC class II antigen presentation R-HSA-2132295 2.226302e-02 1.652 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.509764e-02 1.600 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.526143e-02 1.598 0 0
Glucose metabolism R-HSA-70326 2.683451e-02 1.571 0 0
Signaling by VEGF R-HSA-194138 2.704277e-02 1.568 1 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.773281e-02 1.557 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.806894e-02 1.552 1 1
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.806894e-02 1.552 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.806894e-02 1.552 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.806894e-02 1.552 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.806894e-02 1.552 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.806894e-02 1.552 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.809870e-02 1.551 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.903120e-02 1.537 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.930827e-02 1.533 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.941635e-02 1.531 0 0
NRAGE signals death through JNK R-HSA-193648 2.944497e-02 1.531 0 0
ERK/MAPK targets R-HSA-198753 2.955643e-02 1.529 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.685322e-02 1.434 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.382627e-02 1.471 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.074703e-02 1.512 0 0
Centrosome maturation R-HSA-380287 3.617733e-02 1.442 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.483059e-02 1.458 0 0
Gap junction assembly R-HSA-190861 3.137533e-02 1.503 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.450527e-02 1.462 0 0
Death Receptor Signaling R-HSA-73887 3.571708e-02 1.447 1 0
Signaling by PDGFR in disease R-HSA-9671555 3.450527e-02 1.462 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.685322e-02 1.434 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.382627e-02 1.471 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.074703e-02 1.512 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.242658e-02 1.489 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.737692e-02 1.427 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.799815e-02 1.420 1 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.875551e-02 1.412 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.995903e-02 1.398 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.024200e-02 1.395 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.026557e-02 1.395 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.026557e-02 1.395 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.028099e-02 1.395 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.256936e-02 1.371 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.303497e-02 1.366 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.303497e-02 1.366 0 0
Activation of BH3-only proteins R-HSA-114452 4.303497e-02 1.366 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.654420e-02 1.332 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.654420e-02 1.332 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.498741e-02 1.260 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.498741e-02 1.260 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.739935e-02 1.324 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.739935e-02 1.324 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.739935e-02 1.324 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.739935e-02 1.324 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.523437e-02 1.258 0 0
GAB1 signalosome R-HSA-180292 5.523437e-02 1.258 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.592959e-02 1.338 0 0
MET promotes cell motility R-HSA-8875878 4.917889e-02 1.308 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.447808e-02 1.264 0 0
Signaling by MET R-HSA-6806834 5.267298e-02 1.278 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.955797e-02 1.305 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.242579e-02 1.280 0 0
HIV Infection R-HSA-162906 5.352788e-02 1.271 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.938759e-02 1.306 0 0
Signaling by TGFBR3 R-HSA-9839373 5.353332e-02 1.271 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.643339e-02 1.333 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.523437e-02 1.258 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.523437e-02 1.258 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.052162e-02 1.297 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.423685e-02 1.354 0 0
CREB phosphorylation R-HSA-199920 4.654420e-02 1.332 1 1
Interferon Signaling R-HSA-913531 5.165590e-02 1.287 0 0
Influenza Infection R-HSA-168255 5.132295e-02 1.290 0 0
Inositol phosphate metabolism R-HSA-1483249 5.313895e-02 1.275 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.562771e-02 1.255 1 0
HDACs deacetylate histones R-HSA-3214815 5.655383e-02 1.248 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.655383e-02 1.248 0 0
Cell junction organization R-HSA-446728 5.801082e-02 1.236 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.862514e-02 1.232 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.945338e-02 1.226 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.945338e-02 1.226 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.994142e-02 1.222 0 0
SOS-mediated signalling R-HSA-112412 5.994142e-02 1.222 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.994142e-02 1.222 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.994142e-02 1.222 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.012847e-02 1.221 0 0
Generation of second messenger molecules R-HSA-202433 6.012847e-02 1.221 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.046552e-02 1.218 0 0
Cardiogenesis R-HSA-9733709 6.064527e-02 1.217 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.064527e-02 1.217 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.141871e-02 1.212 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.377177e-02 1.195 0 0
Co-stimulation by CD28 R-HSA-389356 6.401813e-02 1.194 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.556249e-02 1.183 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.556249e-02 1.183 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.556249e-02 1.183 0 0
Interleukin-6 signaling R-HSA-1059683 6.556249e-02 1.183 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.556249e-02 1.183 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.556249e-02 1.183 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.613382e-02 1.180 0 0
PTEN Regulation R-HSA-6807070 6.639382e-02 1.178 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.701501e-02 1.174 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.701501e-02 1.174 0 0
Gene Silencing by RNA R-HSA-211000 6.765254e-02 1.170 0 0
HATs acetylate histones R-HSA-3214847 6.840658e-02 1.165 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.887927e-02 1.162 0 0
MET interacts with TNS proteins R-HSA-8875513 7.290951e-02 1.137 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 7.290951e-02 1.137 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.290951e-02 1.137 0 0
MET activates PTPN11 R-HSA-8865999 7.290951e-02 1.137 0 0
Negative regulation of MET activity R-HSA-6807004 7.300734e-02 1.137 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.300734e-02 1.137 0 0
Nephrin family interactions R-HSA-373753 7.300734e-02 1.137 0 0
RSK activation R-HSA-444257 7.492688e-02 1.125 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.492688e-02 1.125 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.492688e-02 1.125 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.492688e-02 1.125 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.511036e-02 1.124 0 0
Signaling by TGFB family members R-HSA-9006936 7.619313e-02 1.118 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.711505e-02 1.113 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.446544e-02 1.073 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.924068e-02 1.003 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 9.924068e-02 1.003 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 9.138637e-02 1.039 0 0
Lipophagy R-HSA-9613354 9.138637e-02 1.039 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.961224e-02 1.048 1 1
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.961224e-02 1.048 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.293172e-02 1.081 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.293172e-02 1.081 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.288607e-02 1.032 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.025514e-01 0.989 0 0
Meiotic synapsis R-HSA-1221632 9.557237e-02 1.020 0 0
Nucleotide Excision Repair R-HSA-5696398 1.006751e-01 0.997 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.025514e-01 0.989 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.353084e-02 1.029 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.373550e-02 1.028 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 9.138637e-02 1.039 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.353084e-02 1.029 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.010461e-02 1.045 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.015275e-01 0.993 0 0
Oncogene Induced Senescence R-HSA-2559585 8.209736e-02 1.086 0 0
Neurexins and neuroligins R-HSA-6794361 8.864737e-02 1.052 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 9.924068e-02 1.003 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.934519e-02 1.049 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 9.924068e-02 1.003 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.030132e-01 0.987 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.619455e-02 1.017 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.766491e-02 1.010 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.597455e-02 1.018 0 0
Smooth Muscle Contraction R-HSA-445355 9.557237e-02 1.020 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 9.138637e-02 1.039 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.961224e-02 1.048 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 9.288607e-02 1.032 0 0
Netrin-1 signaling R-HSA-373752 9.373550e-02 1.028 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.143826e-02 1.089 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.083310e-01 0.965 0 0
Signal attenuation R-HSA-74749 1.091926e-01 0.962 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.091926e-01 0.962 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.091926e-01 0.962 0 0
Josephin domain DUBs R-HSA-5689877 1.091926e-01 0.962 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.096702e-01 0.960 1 1
Signaling by NOTCH3 R-HSA-9012852 1.103354e-01 0.957 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.111506e-01 0.954 0 0
Circadian clock R-HSA-9909396 1.118549e-01 0.951 0 0
Downstream signal transduction R-HSA-186763 1.127207e-01 0.948 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.127207e-01 0.948 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.155677e-01 0.937 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.166400e-01 0.933 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.166400e-01 0.933 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.169600e-01 0.932 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.171937e-01 0.931 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.172701e-01 0.931 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.172701e-01 0.931 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.172701e-01 0.931 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.181674e-01 0.928 0 0
Cilium Assembly R-HSA-5617833 1.202482e-01 0.920 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.267934e-01 0.897 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.277394e-01 0.894 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.277394e-01 0.894 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.277394e-01 0.894 0 0
IRS activation R-HSA-74713 1.277394e-01 0.894 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.277394e-01 0.894 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.282099e-01 0.892 0 0
Deadenylation of mRNA R-HSA-429947 1.291720e-01 0.889 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.327039e-01 0.877 1 1
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.345131e-01 0.871 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.347111e-01 0.871 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.363463e-01 0.865 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.368107e-01 0.864 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.372604e-01 0.862 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.405355e-01 0.852 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.409112e-01 0.851 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.409112e-01 0.851 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.420917e-01 0.847 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.422471e-01 0.847 0 0
Long-term potentiation R-HSA-9620244 1.422471e-01 0.847 0 0
Deubiquitination R-HSA-5688426 1.426232e-01 0.846 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.441454e-01 0.841 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.457934e-01 0.836 0 0
Striated Muscle Contraction R-HSA-390522 1.461021e-01 0.835 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.481339e-01 0.829 0 0
PKA activation in glucagon signalling R-HSA-164378 1.481339e-01 0.829 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.482984e-01 0.829 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.501340e-01 0.824 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.525915e-01 0.816 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.525915e-01 0.816 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.538872e-01 0.813 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.551024e-01 0.809 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.556450e-01 0.808 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.558686e-01 0.807 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.558686e-01 0.807 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.558686e-01 0.807 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.573432e-01 0.803 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.618011e-01 0.791 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.618011e-01 0.791 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.618011e-01 0.791 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.618011e-01 0.791 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.326083e-01 0.633 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.326083e-01 0.633 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.326083e-01 0.633 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.326083e-01 0.633 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.578523e-01 0.802 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.578523e-01 0.802 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.578523e-01 0.802 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.578523e-01 0.802 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.578523e-01 0.802 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.891038e-01 0.723 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.210871e-01 0.655 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.693169e-01 0.771 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.693169e-01 0.771 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.646215e-01 0.784 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.135887e-01 0.670 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.817289e-01 0.741 0 0
Erythropoietin activates RAS R-HSA-9027284 2.365742e-01 0.626 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.365742e-01 0.626 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.365742e-01 0.626 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.993905e-01 0.700 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.175402e-01 0.662 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.164378e-01 0.665 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.750953e-01 0.757 0 0
Signaling by ERBB4 R-HSA-1236394 1.937366e-01 0.713 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.814096e-01 0.741 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.654392e-01 0.781 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.922117e-01 0.716 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.993905e-01 0.700 0 0
Frs2-mediated activation R-HSA-170968 1.911258e-01 0.719 0 0
RET signaling R-HSA-8853659 1.833957e-01 0.737 0 0
G1 Phase R-HSA-69236 1.801791e-01 0.744 0 0
Cyclin D associated events in G1 R-HSA-69231 1.801791e-01 0.744 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.815879e-01 0.741 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.210871e-01 0.655 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.210871e-01 0.655 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.815879e-01 0.741 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.175402e-01 0.662 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.693169e-01 0.771 0 0
UCH proteinases R-HSA-5689603 2.132043e-01 0.671 0 0
TNF signaling R-HSA-75893 2.087518e-01 0.680 1 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.693169e-01 0.771 0 0
G2/M Checkpoints R-HSA-69481 1.955730e-01 0.709 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.700020e-01 0.770 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.164378e-01 0.665 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 2.210871e-01 0.655 0 0
HCMV Infection R-HSA-9609646 1.661920e-01 0.779 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.968361e-01 0.706 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.609685e-01 0.793 0 0
Signaling by NOTCH1 R-HSA-1980143 2.132043e-01 0.671 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.326083e-01 0.633 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.326083e-01 0.633 0 0
Regulation of PTEN localization R-HSA-8948747 2.210871e-01 0.655 0 0
Signaling by LTK R-HSA-9842663 1.693169e-01 0.771 0 0
TBC/RABGAPs R-HSA-8854214 1.687040e-01 0.773 0 0
DAG and IP3 signaling R-HSA-1489509 1.919716e-01 0.717 0 0
Heme signaling R-HSA-9707616 1.711453e-01 0.767 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.135887e-01 0.670 0 0
Gene expression (Transcription) R-HSA-74160 2.115045e-01 0.675 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.365742e-01 0.626 0 0
Rap1 signalling R-HSA-392517 1.646215e-01 0.784 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.353814e-01 0.628 0 0
Nef and signal transduction R-HSA-164944 1.891038e-01 0.723 0 0
Regulation of KIT signaling R-HSA-1433559 2.135887e-01 0.670 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.290740e-01 0.640 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.654392e-01 0.781 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.326083e-01 0.633 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.578523e-01 0.802 0 0
Protein methylation R-HSA-8876725 2.365742e-01 0.626 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.087518e-01 0.680 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.700020e-01 0.770 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.911258e-01 0.719 0 0
FLT3 signaling in disease R-HSA-9682385 1.833957e-01 0.737 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.210871e-01 0.655 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.210871e-01 0.655 0 0
Signaling by ALK R-HSA-201556 2.239826e-01 0.650 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.743552e-01 0.759 1 0
Interleukin-12 family signaling R-HSA-447115 2.329932e-01 0.633 0 0
G alpha (12/13) signalling events R-HSA-416482 2.334284e-01 0.632 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.331518e-01 0.632 0 0
IRE1alpha activates chaperones R-HSA-381070 1.879781e-01 0.726 0 0
Interleukin-12 signaling R-HSA-9020591 2.132043e-01 0.671 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.419529e-01 0.616 0 0
DNA strand elongation R-HSA-69190 2.470340e-01 0.607 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.974379e-01 0.527 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 2.974379e-01 0.527 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.974379e-01 0.527 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.974379e-01 0.527 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.974379e-01 0.527 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.974379e-01 0.527 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.567943e-01 0.448 0 0
Defective ABCC2 causes DJS R-HSA-5679001 3.567943e-01 0.448 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.567943e-01 0.448 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.567943e-01 0.448 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.534560e-01 0.596 0 0
MET receptor recycling R-HSA-8875656 2.534560e-01 0.596 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.534560e-01 0.596 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.859173e-01 0.544 0 0
WNT mediated activation of DVL R-HSA-201688 2.859173e-01 0.544 0 0
HCN channels R-HSA-1296061 4.111391e-01 0.386 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.111391e-01 0.386 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.111391e-01 0.386 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.111391e-01 0.386 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.111391e-01 0.386 0 0
DNA replication initiation R-HSA-68952 3.182246e-01 0.497 0 0
Phosphorylation of the APC/C R-HSA-176412 2.599571e-01 0.585 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.599571e-01 0.585 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.501726e-01 0.456 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 4.608952e-01 0.336 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.608952e-01 0.336 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.608952e-01 0.336 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.608952e-01 0.336 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.815915e-01 0.418 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 3.815915e-01 0.418 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.815915e-01 0.418 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.313464e-01 0.480 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.552143e-01 0.450 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.552143e-01 0.450 0 0
MET activates RAS signaling R-HSA-8851805 4.123427e-01 0.385 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.123427e-01 0.385 0 0
Polymerase switching R-HSA-69091 4.123427e-01 0.385 0 0
Leading Strand Synthesis R-HSA-69109 4.123427e-01 0.385 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.123427e-01 0.385 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.123427e-01 0.385 0 0
RAF activation R-HSA-5673000 2.969176e-01 0.527 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.330555e-01 0.477 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.330555e-01 0.477 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.330555e-01 0.477 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.819975e-01 0.550 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.789672e-01 0.421 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.558141e-01 0.592 0 0
HIV elongation arrest and recovery R-HSA-167287 3.528377e-01 0.452 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.528377e-01 0.452 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.423150e-01 0.354 0 0
Lagging Strand Synthesis R-HSA-69186 4.025268e-01 0.395 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.025268e-01 0.395 0 0
Signaling by Erythropoietin R-HSA-9006335 3.726211e-01 0.429 0 0
Late endosomal microautophagy R-HSA-9615710 3.726211e-01 0.429 0 0
Removal of the Flap Intermediate R-HSA-69166 4.714204e-01 0.327 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.714204e-01 0.327 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.667634e-01 0.574 0 0
EGFR downregulation R-HSA-182971 4.119952e-01 0.385 0 0
Notch-HLH transcription pathway R-HSA-350054 4.487921e-01 0.348 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.999936e-01 0.398 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.654152e-01 0.437 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.314955e-01 0.365 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.995915e-01 0.301 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.995915e-01 0.301 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.995915e-01 0.301 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.706715e-01 0.431 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.508163e-01 0.346 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.508163e-01 0.346 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.153878e-01 0.501 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.356941e-01 0.361 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.510382e-01 0.346 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.510382e-01 0.346 0 0
Dual Incision in GG-NER R-HSA-5696400 4.887740e-01 0.311 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.887740e-01 0.311 0 0
Translation initiation complex formation R-HSA-72649 4.662869e-01 0.331 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.496117e-01 0.347 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.814207e-01 0.317 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.592682e-01 0.338 0 0
Nucleosome assembly R-HSA-774815 5.013293e-01 0.300 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.013293e-01 0.300 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.206907e-01 0.376 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.964213e-01 0.304 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.964213e-01 0.304 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.964213e-01 0.304 0 0
Peptide chain elongation R-HSA-156902 4.853221e-01 0.314 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.074499e-01 0.512 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.999936e-01 0.398 0 0
Activation of the pre-replicative complex R-HSA-68962 3.923559e-01 0.406 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.133967e-01 0.384 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.599571e-01 0.585 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.592682e-01 0.338 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.182246e-01 0.497 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.815915e-01 0.418 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.699204e-01 0.328 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.274659e-01 0.485 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.365006e-01 0.360 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 2.534560e-01 0.596 0 0
Formation of apoptosome R-HSA-111458 3.182246e-01 0.497 0 0
PI3K/AKT activation R-HSA-198203 3.182246e-01 0.497 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.599571e-01 0.585 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.074499e-01 0.512 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.800780e-01 0.553 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.887740e-01 0.311 0 0
Synthesis of DNA R-HSA-69239 4.796258e-01 0.319 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.859173e-01 0.544 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.079984e-01 0.389 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.935369e-01 0.307 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.355494e-01 0.361 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.783971e-01 0.555 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.123427e-01 0.385 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.954909e-01 0.529 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.668468e-01 0.574 0 0
FOXO-mediated transcription R-HSA-9614085 3.802162e-01 0.420 0 0
Prolonged ERK activation events R-HSA-169893 2.599571e-01 0.585 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.993339e-01 0.399 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.608952e-01 0.336 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.074499e-01 0.512 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.815915e-01 0.418 0 0
Nuclear RNA decay R-HSA-9930044 2.634368e-01 0.579 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.634368e-01 0.579 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.819975e-01 0.550 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.714204e-01 0.327 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.512809e-01 0.346 0 0
Signaling by NOTCH4 R-HSA-9013694 4.365006e-01 0.360 0 0
IGF1R signaling cascade R-HSA-2428924 4.504282e-01 0.346 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.310361e-01 0.480 0 0
DNA Double Strand Break Response R-HSA-5693606 4.922460e-01 0.308 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.937969e-01 0.405 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.937969e-01 0.405 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.937969e-01 0.405 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.937969e-01 0.405 0 0
Homology Directed Repair R-HSA-5693538 4.979583e-01 0.303 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.579183e-01 0.589 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.182246e-01 0.497 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.608952e-01 0.336 0 0
G-protein beta:gamma signalling R-HSA-397795 2.634368e-01 0.579 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.789672e-01 0.421 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.487921e-01 0.348 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.795963e-01 0.421 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.724540e-01 0.429 0 0
PLC beta mediated events R-HSA-112043 2.680692e-01 0.572 0 0
Signaling by FGFR4 R-HSA-5654743 2.970135e-01 0.527 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.229829e-01 0.374 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.783971e-01 0.555 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.644566e-01 0.333 0 0
Myogenesis R-HSA-525793 3.133277e-01 0.504 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.528377e-01 0.452 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.726211e-01 0.429 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 4.512809e-01 0.346 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.887740e-01 0.311 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.576477e-01 0.339 1 0
Interleukin-6 family signaling R-HSA-6783589 2.742604e-01 0.562 0 0
Signaling by FGFR3 R-HSA-5654741 3.274659e-01 0.485 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.123427e-01 0.385 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.330555e-01 0.477 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.508163e-01 0.346 0 0
Signalling to ERKs R-HSA-187687 3.139164e-01 0.503 1 0
Mismatch Repair R-HSA-5358508 3.313464e-01 0.480 0 0
Ca-dependent events R-HSA-111996 2.819975e-01 0.550 0 0
Signalling to ERK5 R-HSA-198765 2.974379e-01 0.527 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.974379e-01 0.527 0 0
MET activates STAT3 R-HSA-8875791 3.567943e-01 0.448 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.534560e-01 0.596 0 0
Unwinding of DNA R-HSA-176974 2.859173e-01 0.544 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.111391e-01 0.386 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.182246e-01 0.497 0 0
Disorders of Developmental Biology R-HSA-9675151 2.836192e-01 0.547 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 3.501726e-01 0.456 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.608952e-01 0.336 0 0
NTRK2 activates RAC1 R-HSA-9032759 4.608952e-01 0.336 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.608952e-01 0.336 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.742604e-01 0.562 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.634368e-01 0.579 0 0
Signaling by NOTCH2 R-HSA-1980145 2.969176e-01 0.527 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.482391e-01 0.458 0 0
Regulation of CDH1 Function R-HSA-9764561 3.512730e-01 0.454 0 0
Intraflagellar transport R-HSA-5620924 3.737906e-01 0.427 0 0
Signaling by FGFR1 R-HSA-5654736 4.964213e-01 0.304 0 0
Metabolism of RNA R-HSA-8953854 2.748046e-01 0.561 1 0
Rab regulation of trafficking R-HSA-9007101 3.736477e-01 0.428 0 0
TCR signaling R-HSA-202403 3.926939e-01 0.406 0 0
Calmodulin induced events R-HSA-111933 3.310361e-01 0.480 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.937969e-01 0.405 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.133277e-01 0.504 0 0
DNA Repair R-HSA-73894 3.563824e-01 0.448 0 0
Protein folding R-HSA-391251 4.127144e-01 0.384 0 0
G-protein mediated events R-HSA-112040 3.444870e-01 0.463 0 0
CaM pathway R-HSA-111997 3.310361e-01 0.480 0 0
PTK6 Activates STAT3 R-HSA-8849474 4.608952e-01 0.336 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.784008e-01 0.320 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.171822e-01 0.380 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.182246e-01 0.497 0 0
TRP channels R-HSA-3295583 3.133277e-01 0.504 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.580502e-01 0.588 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.580502e-01 0.588 0 0
Regulation of beta-cell development R-HSA-186712 3.795963e-01 0.421 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.482391e-01 0.458 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.139288e-01 0.503 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.671586e-01 0.573 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.221824e-01 0.374 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.859173e-01 0.544 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.111391e-01 0.386 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.608952e-01 0.336 0 0
Disorders of Nervous System Development R-HSA-9697154 4.123427e-01 0.385 0 0
Pervasive developmental disorders R-HSA-9005895 4.123427e-01 0.385 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.123427e-01 0.385 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.838257e-01 0.416 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.712881e-01 0.567 0 0
Adherens junctions interactions R-HSA-418990 3.591050e-01 0.445 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.859173e-01 0.544 0 0
Meiosis R-HSA-1500620 4.363674e-01 0.360 0 0
Cell-cell junction organization R-HSA-421270 4.389783e-01 0.358 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.431181e-01 0.465 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.074499e-01 0.512 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.501395e-01 0.456 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.139164e-01 0.503 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.221824e-01 0.374 0 0
RUNX2 regulates bone development R-HSA-8941326 3.310361e-01 0.480 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.567943e-01 0.448 0 0
NADE modulates death signalling R-HSA-205025 4.111391e-01 0.386 0 0
Inositol transporters R-HSA-429593 4.608952e-01 0.336 0 0
Pyrophosphate hydrolysis R-HSA-71737 4.608952e-01 0.336 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 4.608952e-01 0.336 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.423150e-01 0.354 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.487921e-01 0.348 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.937969e-01 0.405 0 0
Mitochondrial biogenesis R-HSA-1592230 4.875480e-01 0.312 0 0
Transmission across Chemical Synapses R-HSA-112315 3.996962e-01 0.398 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.258226e-01 0.371 0 0
Hedgehog 'off' state R-HSA-5610787 2.797133e-01 0.553 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.525245e-01 0.598 0 0
p75NTR signals via NF-kB R-HSA-193639 4.995915e-01 0.301 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.507593e-01 0.455 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.512809e-01 0.346 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 2.534560e-01 0.596 0 0
PECAM1 interactions R-HSA-210990 3.501726e-01 0.456 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.487921e-01 0.348 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.650167e-01 0.577 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.804888e-01 0.552 0 0
Signal transduction by L1 R-HSA-445144 3.789672e-01 0.421 0 0
DNA Damage Bypass R-HSA-73893 3.893005e-01 0.410 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.838257e-01 0.416 0 0
Signaling by Hedgehog R-HSA-5358351 3.952996e-01 0.403 0 0
The NLRP1 inflammasome R-HSA-844455 3.567943e-01 0.448 0 0
Interleukin-18 signaling R-HSA-9012546 2.534560e-01 0.596 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.182246e-01 0.497 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.608952e-01 0.336 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.634368e-01 0.579 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.423150e-01 0.354 0 0
MAP kinase activation R-HSA-450294 2.680692e-01 0.572 1 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.827521e-01 0.417 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.713797e-01 0.327 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.681354e-01 0.330 0 0
Interleukin-17 signaling R-HSA-448424 3.838257e-01 0.416 1 0
p75NTR recruits signalling complexes R-HSA-209543 4.123427e-01 0.385 0 0
Maturation of nucleoprotein R-HSA-9683610 4.423150e-01 0.354 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.699204e-01 0.328 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.487921e-01 0.348 0 0
Signaling by Interleukins R-HSA-449147 3.611236e-01 0.442 1 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.859173e-01 0.544 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.608952e-01 0.336 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.815915e-01 0.418 0 0
Potential therapeutics for SARS R-HSA-9679191 4.139017e-01 0.383 0 0
Sensory processing of sound R-HSA-9659379 3.623811e-01 0.441 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.356941e-01 0.361 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.608952e-01 0.336 0 0
OAS antiviral response R-HSA-8983711 4.123427e-01 0.385 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.931075e-01 0.307 0 0
Signaling by Leptin R-HSA-2586552 3.182246e-01 0.497 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.423150e-01 0.354 0 0
Signal regulatory protein family interactions R-HSA-391160 4.714204e-01 0.327 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.046704e-01 0.393 0 0
Interleukin-15 signaling R-HSA-8983432 4.123427e-01 0.385 0 0
Transcription of the HIV genome R-HSA-167172 5.059779e-01 0.296 0 0
PDE3B signalling R-HSA-165160 5.064499e-01 0.295 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.064499e-01 0.295 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.064499e-01 0.295 0 0
PKB-mediated events R-HSA-109703 5.064499e-01 0.295 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.064499e-01 0.295 0 0
Signaling by MAPK mutants R-HSA-9652817 5.064499e-01 0.295 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.064499e-01 0.295 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.064499e-01 0.295 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.064499e-01 0.295 0 0
Synthesis of PS R-HSA-1483101 5.064499e-01 0.295 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.064499e-01 0.295 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.064499e-01 0.295 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.064499e-01 0.295 0 0
mRNA Splicing R-HSA-72172 5.093920e-01 0.293 0 0
SARS-CoV Infections R-HSA-9679506 5.099050e-01 0.293 0 0
IRS-mediated signalling R-HSA-112399 5.112711e-01 0.291 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.122317e-01 0.291 1 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.122317e-01 0.291 1 0
TCF dependent signaling in response to WNT R-HSA-201681 5.154249e-01 0.288 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.176236e-01 0.286 0 0
G1/S-Specific Transcription R-HSA-69205 5.256090e-01 0.279 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.256090e-01 0.279 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.267785e-01 0.278 0 0
Killing mechanisms R-HSA-9664420 5.267785e-01 0.278 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.267785e-01 0.278 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.267785e-01 0.278 0 0
Activation of SMO R-HSA-5635838 5.267785e-01 0.278 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.267785e-01 0.278 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.267816e-01 0.278 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.288600e-01 0.277 0 0
Chromosome Maintenance R-HSA-73886 5.288600e-01 0.277 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.331709e-01 0.273 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.336437e-01 0.273 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.336437e-01 0.273 0 0
Adipogenesis R-HSA-9843745 5.342973e-01 0.272 0 0
MET activates PTK2 signaling R-HSA-8874081 5.363994e-01 0.271 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.363994e-01 0.271 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.363994e-01 0.271 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.404552e-01 0.267 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.448893e-01 0.264 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.463627e-01 0.263 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.463627e-01 0.263 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.481576e-01 0.261 0 0
Signaling by LTK in cancer R-HSA-9842640 5.481576e-01 0.261 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.481576e-01 0.261 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.481576e-01 0.261 0 0
MET Receptor Activation R-HSA-6806942 5.481576e-01 0.261 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.481576e-01 0.261 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.481576e-01 0.261 0 0
HDL clearance R-HSA-8964011 5.481576e-01 0.261 0 0
Neurofascin interactions R-HSA-447043 5.481576e-01 0.261 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.481576e-01 0.261 0 0
GPER1 signaling R-HSA-9634597 5.495070e-01 0.260 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.495070e-01 0.260 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.529465e-01 0.257 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.529465e-01 0.257 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.529465e-01 0.257 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.529465e-01 0.257 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.529465e-01 0.257 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.547331e-01 0.256 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.570390e-01 0.254 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.570390e-01 0.254 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.570390e-01 0.254 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.570390e-01 0.254 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.611110e-01 0.251 0 0
Degradation of CDH1 R-HSA-9766229 5.650616e-01 0.248 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.724927e-01 0.242 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.754512e-01 0.240 1 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.771163e-01 0.239 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.771163e-01 0.239 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.771163e-01 0.239 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.780735e-01 0.238 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.780735e-01 0.238 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.783092e-01 0.238 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.783092e-01 0.238 0 0
G1/S Transition R-HSA-69206 5.789137e-01 0.237 0 0
PI3K Cascade R-HSA-109704 5.803376e-01 0.236 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.827318e-01 0.235 0 0
Signaling by PDGF R-HSA-186797 5.827318e-01 0.235 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 5.863431e-01 0.232 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.863431e-01 0.232 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.863431e-01 0.232 0 0
PTK6 Expression R-HSA-8849473 5.863431e-01 0.232 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.863431e-01 0.232 0 0
VLDL clearance R-HSA-8964046 5.863431e-01 0.232 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 5.863431e-01 0.232 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.863431e-01 0.232 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.863431e-01 0.232 0 0
Netrin mediated repulsion signals R-HSA-418886 5.863431e-01 0.232 0 0
CHL1 interactions R-HSA-447041 5.863431e-01 0.232 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 5.863431e-01 0.232 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.863431e-01 0.232 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.863431e-01 0.232 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.879096e-01 0.231 0 0
Integration of energy metabolism R-HSA-163685 5.915656e-01 0.228 0 0
Neuronal System R-HSA-112316 5.919185e-01 0.228 0 0
HIV Transcription Elongation R-HSA-167169 5.951159e-01 0.225 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.951159e-01 0.225 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.951159e-01 0.225 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.951159e-01 0.225 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.951159e-01 0.225 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.951159e-01 0.225 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.966118e-01 0.224 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.966118e-01 0.224 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.966118e-01 0.224 0 0
Platelet calcium homeostasis R-HSA-418360 5.966118e-01 0.224 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.966118e-01 0.224 0 0
Glucagon-type ligand receptors R-HSA-420092 5.966118e-01 0.224 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.978927e-01 0.223 0 0
tRNA processing R-HSA-72306 5.997834e-01 0.222 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.008146e-01 0.221 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.012065e-01 0.221 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.016176e-01 0.221 0 0
PKA activation R-HSA-163615 6.021487e-01 0.220 0 0
Apoptotic factor-mediated response R-HSA-111471 6.021487e-01 0.220 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.021487e-01 0.220 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.021487e-01 0.220 0 0
Nephron development R-HSA-9831926 6.021487e-01 0.220 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.032794e-01 0.219 1 0
Developmental Cell Lineages R-HSA-9734767 6.054155e-01 0.218 0 0
Signaling by NOTCH R-HSA-157118 6.073953e-01 0.217 0 0
Viral Infection Pathways R-HSA-9824446 6.085569e-01 0.216 0 0
Insulin receptor signalling cascade R-HSA-74751 6.097784e-01 0.215 0 0
mRNA 3'-end processing R-HSA-72187 6.100029e-01 0.215 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.100029e-01 0.215 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.115172e-01 0.214 0 0
FLT3 Signaling R-HSA-9607240 6.115172e-01 0.214 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.140066e-01 0.212 1 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.155104e-01 0.211 0 0
DAP12 signaling R-HSA-2424491 6.155104e-01 0.211 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.155104e-01 0.211 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.213036e-01 0.207 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.213036e-01 0.207 0 0
phospho-PLA2 pathway R-HSA-111995 6.213036e-01 0.207 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.213036e-01 0.207 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.213036e-01 0.207 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.213036e-01 0.207 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.213036e-01 0.207 0 0
Regulation by c-FLIP R-HSA-3371378 6.213036e-01 0.207 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.213036e-01 0.207 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.213036e-01 0.207 0 0
Dimerization of procaspase-8 R-HSA-69416 6.213036e-01 0.207 0 0
Sodium/Proton exchangers R-HSA-425986 6.213036e-01 0.207 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.213036e-01 0.207 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.233140e-01 0.205 1 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.233140e-01 0.205 1 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.233140e-01 0.205 1 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.242255e-01 0.205 1 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.243703e-01 0.205 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.243703e-01 0.205 0 0
Regulation of signaling by CBL R-HSA-912631 6.251704e-01 0.204 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.251704e-01 0.204 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.251704e-01 0.204 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.251704e-01 0.204 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.251704e-01 0.204 0 0
Maturation of nucleoprotein R-HSA-9694631 6.251704e-01 0.204 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.275016e-01 0.202 0 0
HIV Transcription Initiation R-HSA-167161 6.275016e-01 0.202 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.275016e-01 0.202 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.275016e-01 0.202 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.338013e-01 0.198 0 0
RNA Polymerase I Transcription R-HSA-73864 6.344780e-01 0.198 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.384154e-01 0.195 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.404400e-01 0.194 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.471446e-01 0.189 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.471446e-01 0.189 0 0
Formation of definitive endoderm R-HSA-9823730 6.471446e-01 0.189 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.471446e-01 0.189 0 0
Signaling by NODAL R-HSA-1181150 6.471446e-01 0.189 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.484578e-01 0.188 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.514772e-01 0.186 0 0
CASP8 activity is inhibited R-HSA-5218900 6.533112e-01 0.185 0 0
Calcineurin activates NFAT R-HSA-2025928 6.533112e-01 0.185 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.533112e-01 0.185 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.533112e-01 0.185 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.533112e-01 0.185 0 0
ARMS-mediated activation R-HSA-170984 6.533112e-01 0.185 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.533112e-01 0.185 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.533112e-01 0.185 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.533112e-01 0.185 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.533112e-01 0.185 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.533112e-01 0.185 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.533112e-01 0.185 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.533112e-01 0.185 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.558369e-01 0.183 0 0
Signaling by FGFR2 R-HSA-5654738 6.577805e-01 0.182 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.581841e-01 0.182 0 0
Signaling by SCF-KIT R-HSA-1433557 6.581841e-01 0.182 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.630040e-01 0.178 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.636503e-01 0.178 1 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.680840e-01 0.175 0 0
Signalling to RAS R-HSA-167044 6.680840e-01 0.175 1 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.680840e-01 0.175 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.680840e-01 0.175 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.680840e-01 0.175 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.680840e-01 0.175 0 0
Basigin interactions R-HSA-210991 6.680840e-01 0.175 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.685345e-01 0.175 0 0
Signaling by WNT R-HSA-195721 6.789757e-01 0.168 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.826154e-01 0.166 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.826154e-01 0.166 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.826154e-01 0.166 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.826154e-01 0.166 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.826154e-01 0.166 0 0
Interleukin-27 signaling R-HSA-9020956 6.826154e-01 0.166 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.826154e-01 0.166 0 0
2-LTR circle formation R-HSA-164843 6.826154e-01 0.166 0 0
MAPK3 (ERK1) activation R-HSA-110056 6.826154e-01 0.166 0 0
Regulation of CDH11 function R-HSA-9762292 6.826154e-01 0.166 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.849726e-01 0.164 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.871130e-01 0.163 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.871130e-01 0.163 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.871130e-01 0.163 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.880063e-01 0.162 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.880063e-01 0.162 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 6.880063e-01 0.162 0 0
Dual incision in TC-NER R-HSA-6782135 6.912445e-01 0.160 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.912445e-01 0.160 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.962367e-01 0.157 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.007935e-01 0.154 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.007935e-01 0.154 0 0
Mitophagy R-HSA-5205647 7.007935e-01 0.154 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.007935e-01 0.154 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.007935e-01 0.154 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.009122e-01 0.154 0 0
Diseases of DNA repair R-HSA-9675135 7.009122e-01 0.154 0 0
Platelet degranulation R-HSA-114608 7.069192e-01 0.151 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.069340e-01 0.151 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.069340e-01 0.151 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.069340e-01 0.151 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.069340e-01 0.151 0 0
Signaling by KIT in disease R-HSA-9669938 7.069340e-01 0.151 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.069340e-01 0.151 0 0
LDL clearance R-HSA-8964038 7.069340e-01 0.151 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.071022e-01 0.151 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.071022e-01 0.151 0 0
Signaling by APC mutants R-HSA-4839744 7.094441e-01 0.149 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.094441e-01 0.149 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.094441e-01 0.149 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.094441e-01 0.149 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.094441e-01 0.149 0 0
vRNP Assembly R-HSA-192905 7.094441e-01 0.149 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.094441e-01 0.149 0 0
Synthesis of PI R-HSA-1483226 7.094441e-01 0.149 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.094441e-01 0.149 0 0
Bicarbonate transporters R-HSA-425381 7.094441e-01 0.149 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.094441e-01 0.149 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.094441e-01 0.149 0 0
Suppression of apoptosis R-HSA-9635465 7.094441e-01 0.149 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.094441e-01 0.149 0 0
Transport of RCbl within the body R-HSA-9758890 7.094441e-01 0.149 0 0
Generic Transcription Pathway R-HSA-212436 7.107099e-01 0.148 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.128153e-01 0.147 0 0
rRNA processing R-HSA-72312 7.129746e-01 0.147 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.142671e-01 0.146 0 0
tRNA Aminoacylation R-HSA-379724 7.155931e-01 0.145 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.160017e-01 0.145 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.160017e-01 0.145 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.160017e-01 0.145 0 0
Eukaryotic Translation Termination R-HSA-72764 7.167317e-01 0.145 0 0
RNA Polymerase II Transcription R-HSA-73857 7.192858e-01 0.143 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.216325e-01 0.142 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.231071e-01 0.141 0 0
Adaptive Immune System R-HSA-1280218 7.235547e-01 0.141 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.248929e-01 0.140 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.248929e-01 0.140 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.248929e-01 0.140 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.248929e-01 0.140 0 0
Biosynthesis of maresins R-HSA-9018682 7.248929e-01 0.140 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.248929e-01 0.140 0 0
Growth hormone receptor signaling R-HSA-982772 7.248929e-01 0.140 0 0
Gluconeogenesis R-HSA-70263 7.271788e-01 0.138 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.272448e-01 0.138 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.306040e-01 0.136 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.340065e-01 0.134 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.340065e-01 0.134 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.340065e-01 0.134 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.340065e-01 0.134 0 0
Integration of provirus R-HSA-162592 7.340065e-01 0.134 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.340065e-01 0.134 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 7.340065e-01 0.134 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.340065e-01 0.134 0 0
Plasmalogen biosynthesis R-HSA-75896 7.340065e-01 0.134 0 0
NF-kB is activated and signals survival R-HSA-209560 7.340065e-01 0.134 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.340065e-01 0.134 0 0
Signaling by AXIN mutants R-HSA-4839735 7.340065e-01 0.134 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.340065e-01 0.134 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.340065e-01 0.134 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.340065e-01 0.134 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.340065e-01 0.134 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.340065e-01 0.134 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.348874e-01 0.134 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.348874e-01 0.134 1 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.363290e-01 0.133 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.385482e-01 0.132 0 0
Protein ubiquitination R-HSA-8852135 7.394758e-01 0.131 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.419113e-01 0.130 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.419113e-01 0.130 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.419113e-01 0.130 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.495048e-01 0.125 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.495048e-01 0.125 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.495672e-01 0.125 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.516838e-01 0.124 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.516838e-01 0.124 0 0
Toll-like Receptor Cascades R-HSA-168898 7.548745e-01 0.122 1 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.564938e-01 0.121 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.564938e-01 0.121 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.564938e-01 0.121 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.564938e-01 0.121 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.564938e-01 0.121 0 0
Repression of WNT target genes R-HSA-4641265 7.564938e-01 0.121 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.564938e-01 0.121 0 0
Proline catabolism R-HSA-70688 7.564938e-01 0.121 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.564938e-01 0.121 0 0
Interleukin-35 Signalling R-HSA-8984722 7.564938e-01 0.121 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 7.564938e-01 0.121 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.564938e-01 0.121 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.564938e-01 0.121 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.564938e-01 0.121 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.580199e-01 0.120 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.580199e-01 0.120 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.580199e-01 0.120 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.580199e-01 0.120 0 0
Tight junction interactions R-HSA-420029 7.580199e-01 0.120 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.580199e-01 0.120 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.580199e-01 0.120 0 0
Interleukin-7 signaling R-HSA-1266695 7.580199e-01 0.120 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.580263e-01 0.120 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.580263e-01 0.120 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.588279e-01 0.120 1 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.588279e-01 0.120 1 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.620578e-01 0.118 0 0
HCMV Late Events R-HSA-9610379 7.688597e-01 0.114 0 0
PCP/CE pathway R-HSA-4086400 7.688916e-01 0.114 0 0
Selenocysteine synthesis R-HSA-2408557 7.700278e-01 0.113 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.708682e-01 0.113 0 0
Metalloprotease DUBs R-HSA-5689901 7.732510e-01 0.112 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.732510e-01 0.112 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.732510e-01 0.112 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.744605e-01 0.111 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.744605e-01 0.111 0 0
Orc1 removal from chromatin R-HSA-68949 7.744605e-01 0.111 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.744605e-01 0.111 0 0
Cellular response to starvation R-HSA-9711097 7.754680e-01 0.110 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 7.770812e-01 0.110 0 0
Formation of axial mesoderm R-HSA-9796292 7.770812e-01 0.110 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 7.770812e-01 0.110 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.770812e-01 0.110 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.770812e-01 0.110 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.776053e-01 0.109 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.781280e-01 0.109 0 0
Cellular response to chemical stress R-HSA-9711123 7.797575e-01 0.108 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.831472e-01 0.106 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.831472e-01 0.106 0 0
Diseases of Immune System R-HSA-5260271 7.831472e-01 0.106 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.831472e-01 0.106 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.831472e-01 0.106 0 0
Interleukin-2 family signaling R-HSA-451927 7.831472e-01 0.106 0 0
Hemostasis R-HSA-109582 7.849817e-01 0.105 0 0
Viral mRNA Translation R-HSA-192823 7.860848e-01 0.105 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.870837e-01 0.104 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.876376e-01 0.104 0 0
Cristae formation R-HSA-8949613 7.876376e-01 0.104 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.876376e-01 0.104 0 0
Signaling by BMP R-HSA-201451 7.876376e-01 0.104 0 0
Opioid Signalling R-HSA-111885 7.937965e-01 0.100 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.959292e-01 0.099 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.959292e-01 0.099 0 0
Hydrolysis of LPC R-HSA-1483115 7.959292e-01 0.099 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.959292e-01 0.099 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 7.959292e-01 0.099 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.959292e-01 0.099 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.959292e-01 0.099 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.959292e-01 0.099 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.959292e-01 0.099 0 0
Glycerophospholipid catabolism R-HSA-6814848 7.959292e-01 0.099 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.959292e-01 0.099 0 0
Zinc transporters R-HSA-435354 7.959292e-01 0.099 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.012137e-01 0.096 0 0
Inflammasomes R-HSA-622312 8.012137e-01 0.096 0 0
Ribosome-associated quality control R-HSA-9948299 8.032640e-01 0.095 0 0
Paracetamol ADME R-HSA-9753281 8.054946e-01 0.094 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.060721e-01 0.094 0 0
Muscle contraction R-HSA-397014 8.099009e-01 0.092 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.131845e-01 0.090 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.131845e-01 0.090 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.131845e-01 0.090 0 0
p38MAPK events R-HSA-171007 8.131845e-01 0.090 1 1
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.131845e-01 0.090 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.131845e-01 0.090 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.131845e-01 0.090 0 0
Other semaphorin interactions R-HSA-416700 8.131845e-01 0.090 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.131845e-01 0.090 0 0
mRNA Capping R-HSA-72086 8.140134e-01 0.089 0 0
DARPP-32 events R-HSA-180024 8.140134e-01 0.089 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.150352e-01 0.089 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.260709e-01 0.083 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.260709e-01 0.083 0 0
Interleukin-37 signaling R-HSA-9008059 8.260709e-01 0.083 0 0
Defective pyroptosis R-HSA-9710421 8.269200e-01 0.083 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.269200e-01 0.083 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.289818e-01 0.081 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.289818e-01 0.081 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.289818e-01 0.081 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.289818e-01 0.081 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.289818e-01 0.081 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.289818e-01 0.081 0 0
Negative regulation of FLT3 R-HSA-9706369 8.289818e-01 0.081 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.289818e-01 0.081 0 0
Differentiation of T cells R-HSA-9945266 8.289818e-01 0.081 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.289818e-01 0.081 0 0
Attachment and Entry R-HSA-9678110 8.289818e-01 0.081 0 0
Atorvastatin ADME R-HSA-9754706 8.289818e-01 0.081 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.357436e-01 0.078 0 0
DAP12 interactions R-HSA-2172127 8.366046e-01 0.077 0 0
RMTs methylate histone arginines R-HSA-3214858 8.366046e-01 0.077 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.374203e-01 0.077 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.374203e-01 0.077 0 0
Cargo concentration in the ER R-HSA-5694530 8.374203e-01 0.077 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.374203e-01 0.077 0 0
Trafficking of AMPA receptors R-HSA-399719 8.374203e-01 0.077 0 0
Telomere Maintenance R-HSA-157579 8.382576e-01 0.077 0 0
Peroxisomal protein import R-HSA-9033241 8.413695e-01 0.075 0 0
Extension of Telomeres R-HSA-180786 8.413695e-01 0.075 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.413695e-01 0.075 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.434441e-01 0.074 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.434441e-01 0.074 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.434441e-01 0.074 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.434441e-01 0.074 0 0
Signaling by FGFR R-HSA-190236 8.448185e-01 0.073 0 0
Regulation of insulin secretion R-HSA-422356 8.448185e-01 0.073 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.458180e-01 0.073 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.458180e-01 0.073 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.458180e-01 0.073 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.458180e-01 0.073 0 0
Signaling by FGFR in disease R-HSA-1226099 8.481524e-01 0.072 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.494174e-01 0.071 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.545767e-01 0.068 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.545767e-01 0.068 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.545767e-01 0.068 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.566842e-01 0.067 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.566842e-01 0.067 0 0
Glycogen storage diseases R-HSA-3229121 8.566842e-01 0.067 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 8.566842e-01 0.067 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.566842e-01 0.067 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.566842e-01 0.067 0 0
Catecholamine biosynthesis R-HSA-209905 8.566842e-01 0.067 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.566842e-01 0.067 0 0
Choline catabolism R-HSA-6798163 8.566842e-01 0.067 0 0
Aquaporin-mediated transport R-HSA-445717 8.571170e-01 0.067 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.581277e-01 0.066 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.581277e-01 0.066 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.590197e-01 0.066 0 0
Ub-specific processing proteases R-HSA-5689880 8.635928e-01 0.064 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.660210e-01 0.062 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.675509e-01 0.062 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.675509e-01 0.062 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.675509e-01 0.062 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.675509e-01 0.062 0 0
Heme degradation R-HSA-189483 8.675509e-01 0.062 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.688053e-01 0.061 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.688053e-01 0.061 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.688053e-01 0.061 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.688053e-01 0.061 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.688053e-01 0.061 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 8.688053e-01 0.061 0 0
Tie2 Signaling R-HSA-210993 8.688053e-01 0.061 0 0
Platelet sensitization by LDL R-HSA-432142 8.688053e-01 0.061 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.688053e-01 0.061 0 0
PI Metabolism R-HSA-1483255 8.689494e-01 0.061 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.763958e-01 0.057 0 0
eNOS activation R-HSA-203615 8.763958e-01 0.057 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.763958e-01 0.057 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.763958e-01 0.057 0 0
Signal amplification R-HSA-392518 8.763958e-01 0.057 0 0
Selenoamino acid metabolism R-HSA-2408522 8.773754e-01 0.057 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.782294e-01 0.056 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.782904e-01 0.056 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.782904e-01 0.056 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.799019e-01 0.056 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.799019e-01 0.056 0 0
Pyrimidine biosynthesis R-HSA-500753 8.799019e-01 0.056 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.799019e-01 0.056 0 0
Translesion Synthesis by POLH R-HSA-110320 8.799019e-01 0.056 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 8.799019e-01 0.056 0 0
The NLRP3 inflammasome R-HSA-844456 8.799019e-01 0.056 0 0
Other interleukin signaling R-HSA-449836 8.799019e-01 0.056 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.799019e-01 0.056 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.828976e-01 0.054 0 0
Regulation of Apoptosis R-HSA-169911 8.846928e-01 0.053 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.846928e-01 0.053 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.846928e-01 0.053 0 0
Parasite infection R-HSA-9664407 8.847076e-01 0.053 0 0
Leishmania phagocytosis R-HSA-9664417 8.847076e-01 0.053 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.847076e-01 0.053 0 0
Signaling by Insulin receptor R-HSA-74752 8.851364e-01 0.053 0 0
DNA Replication R-HSA-69306 8.871141e-01 0.052 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.887784e-01 0.051 0 0
SLC transporter disorders R-HSA-5619102 8.897050e-01 0.051 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.900605e-01 0.051 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.900605e-01 0.051 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.900605e-01 0.051 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.900605e-01 0.051 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.900605e-01 0.051 0 0
Glycogen synthesis R-HSA-3322077 8.900605e-01 0.051 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 8.900605e-01 0.051 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.900605e-01 0.051 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.900605e-01 0.051 0 0
Creatine metabolism R-HSA-71288 8.900605e-01 0.051 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.900605e-01 0.051 0 0
Pregnenolone biosynthesis R-HSA-196108 8.900605e-01 0.051 0 0
Protein hydroxylation R-HSA-9629569 8.900605e-01 0.051 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.903828e-01 0.050 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.924713e-01 0.049 0 0
RNA Polymerase III Transcription R-HSA-74158 8.924713e-01 0.049 0 0
GPVI-mediated activation cascade R-HSA-114604 8.924713e-01 0.049 0 0
Reproduction R-HSA-1474165 8.958636e-01 0.048 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.985034e-01 0.046 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.985034e-01 0.046 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.992908e-01 0.046 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.993604e-01 0.046 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.993604e-01 0.046 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 8.993604e-01 0.046 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.993604e-01 0.046 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 8.993604e-01 0.046 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.993604e-01 0.046 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.997595e-01 0.046 0 0
Degradation of DVL R-HSA-4641258 8.997595e-01 0.046 0 0
Regulated Necrosis R-HSA-5218859 9.021353e-01 0.045 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.027289e-01 0.044 0 0
Stimuli-sensing channels R-HSA-2672351 9.037036e-01 0.044 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.045374e-01 0.044 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.065848e-01 0.043 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.065848e-01 0.043 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.078741e-01 0.042 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.078741e-01 0.042 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.078741e-01 0.042 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.078741e-01 0.042 0 0
Serine metabolism R-HSA-977347 9.078741e-01 0.042 0 0
Glutathione synthesis and recycling R-HSA-174403 9.078741e-01 0.042 0 0
Attachment and Entry R-HSA-9694614 9.078741e-01 0.042 0 0
Ribavirin ADME R-HSA-9755088 9.078741e-01 0.042 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.124557e-01 0.040 0 0
Stabilization of p53 R-HSA-69541 9.129732e-01 0.040 0 0
G alpha (z) signalling events R-HSA-418597 9.156410e-01 0.038 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.156681e-01 0.038 0 0
FGFR2 alternative splicing R-HSA-6803529 9.156681e-01 0.038 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.156681e-01 0.038 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.156681e-01 0.038 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.156681e-01 0.038 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.156681e-01 0.038 0 0
Hedgehog 'on' state R-HSA-5632684 9.172432e-01 0.038 0 0
Formation of the cornified envelope R-HSA-6809371 9.188772e-01 0.037 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.228031e-01 0.035 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.228031e-01 0.035 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.228031e-01 0.035 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.228031e-01 0.035 0 0
Carnitine shuttle R-HSA-200425 9.228031e-01 0.035 0 0
Syndecan interactions R-HSA-3000170 9.228031e-01 0.035 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.234245e-01 0.035 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.245387e-01 0.034 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.245387e-01 0.034 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.245387e-01 0.034 0 0
Synthesis of PA R-HSA-1483166 9.255554e-01 0.034 0 0
Ca2+ pathway R-HSA-4086398 9.261209e-01 0.033 0 0
CYP2E1 reactions R-HSA-211999 9.293348e-01 0.032 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.293348e-01 0.032 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.293348e-01 0.032 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.293348e-01 0.032 0 0
Complex III assembly R-HSA-9865881 9.293348e-01 0.032 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.293348e-01 0.032 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.297625e-01 0.032 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.297625e-01 0.032 0 0
Translation of Structural Proteins R-HSA-9683701 9.297625e-01 0.032 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.312237e-01 0.031 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.353142e-01 0.029 0 0
Hyaluronan degradation R-HSA-2160916 9.353142e-01 0.029 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.353142e-01 0.029 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.353142e-01 0.029 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.353142e-01 0.029 0 0
Laminin interactions R-HSA-3000157 9.353142e-01 0.029 0 0
Base Excision Repair R-HSA-73884 9.360248e-01 0.029 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.392008e-01 0.027 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.407880e-01 0.027 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.407880e-01 0.027 0 0
RSV-host interactions R-HSA-9833110 9.419774e-01 0.026 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.422490e-01 0.026 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.434557e-01 0.025 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.434557e-01 0.025 1 1
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.457989e-01 0.024 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.457989e-01 0.024 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.457989e-01 0.024 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.457989e-01 0.024 0 0
Insulin processing R-HSA-264876 9.457989e-01 0.024 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.457989e-01 0.024 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.462490e-01 0.024 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.474262e-01 0.023 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.474262e-01 0.023 0 0
Platelet homeostasis R-HSA-418346 9.476158e-01 0.023 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.478338e-01 0.023 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.484938e-01 0.023 0 0
Co-inhibition by PD-1 R-HSA-389948 9.485179e-01 0.023 0 0
Telomere Extension By Telomerase R-HSA-171319 9.503860e-01 0.022 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.503860e-01 0.022 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.503860e-01 0.022 0 0
Pyrimidine salvage R-HSA-73614 9.503860e-01 0.022 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.503860e-01 0.022 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.511299e-01 0.022 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.545852e-01 0.020 0 0
DNA methylation R-HSA-5334118 9.545852e-01 0.020 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.545852e-01 0.020 0 0
Cellular response to hypoxia R-HSA-1234174 9.554121e-01 0.020 0 0
Neutrophil degranulation R-HSA-6798695 9.573245e-01 0.019 0 0
Metal ion SLC transporters R-HSA-425410 9.578031e-01 0.019 0 0
Gastrulation R-HSA-9758941 9.578774e-01 0.019 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.582334e-01 0.019 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.584291e-01 0.018 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.584291e-01 0.018 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.587176e-01 0.018 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.608032e-01 0.017 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.608032e-01 0.017 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.612771e-01 0.017 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.616952e-01 0.017 0 0
Budding and maturation of HIV virion R-HSA-162588 9.619480e-01 0.017 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.619480e-01 0.017 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.628048e-01 0.016 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.630302e-01 0.016 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.630302e-01 0.016 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.630302e-01 0.016 0 0
Azathioprine ADME R-HSA-9748787 9.635980e-01 0.016 0 0
Protein localization R-HSA-9609507 9.649642e-01 0.015 0 0
Signaling by WNT in cancer R-HSA-4791275 9.651691e-01 0.015 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.651691e-01 0.015 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.656932e-01 0.015 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.662008e-01 0.015 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.662008e-01 0.015 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.662008e-01 0.015 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.679263e-01 0.014 0 0
COPII-mediated vesicle transport R-HSA-204005 9.679263e-01 0.014 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.679263e-01 0.014 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.681178e-01 0.014 0 0
Parasitic Infection Pathways R-HSA-9824443 9.683870e-01 0.014 0 0
Leishmania infection R-HSA-9658195 9.683870e-01 0.014 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.708170e-01 0.013 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.708170e-01 0.013 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.708793e-01 0.013 0 0
Nucleotide biosynthesis R-HSA-8956320 9.708793e-01 0.013 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.729778e-01 0.012 0 0
ER-Phagosome pathway R-HSA-1236974 9.731535e-01 0.012 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.732878e-01 0.012 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.732878e-01 0.012 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.732878e-01 0.012 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.732878e-01 0.012 0 0
Hyaluronan metabolism R-HSA-2142845 9.732878e-01 0.012 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.732878e-01 0.012 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.732878e-01 0.012 0 0
Neurotransmitter release cycle R-HSA-112310 9.747651e-01 0.011 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.755496e-01 0.011 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.755496e-01 0.011 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.755496e-01 0.011 0 0
PERK regulates gene expression R-HSA-381042 9.755496e-01 0.011 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.766541e-01 0.010 0 0
Ion homeostasis R-HSA-5578775 9.767453e-01 0.010 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.770689e-01 0.010 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.776200e-01 0.010 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.776200e-01 0.010 0 0
Triglyceride catabolism R-HSA-163560 9.776200e-01 0.010 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.776200e-01 0.010 0 0
Degradation of AXIN R-HSA-4641257 9.795151e-01 0.009 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.795151e-01 0.009 0 0
NCAM1 interactions R-HSA-419037 9.795151e-01 0.009 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.795151e-01 0.009 0 0
Collagen chain trimerization R-HSA-8948216 9.795151e-01 0.009 0 0
Translation of Structural Proteins R-HSA-9694635 9.799807e-01 0.009 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.800021e-01 0.009 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.812499e-01 0.008 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.813008e-01 0.008 0 0
ABC transporter disorders R-HSA-5619084 9.813008e-01 0.008 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.813008e-01 0.008 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.814601e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.815470e-01 0.008 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.828379e-01 0.008 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.828379e-01 0.008 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.840729e-01 0.007 0 0
Glycogen metabolism R-HSA-8982491 9.842915e-01 0.007 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.842915e-01 0.007 0 0
Amyloid fiber formation R-HSA-977225 9.847802e-01 0.007 0 0
Mitochondrial protein import R-HSA-1268020 9.852414e-01 0.006 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.856220e-01 0.006 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.856220e-01 0.006 0 0
Maturation of spike protein R-HSA-9694548 9.856220e-01 0.006 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.856220e-01 0.006 0 0
G alpha (s) signalling events R-HSA-418555 9.860409e-01 0.006 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.863263e-01 0.006 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.865793e-01 0.006 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.868399e-01 0.006 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.868399e-01 0.006 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.868399e-01 0.006 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.868399e-01 0.006 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.871479e-01 0.006 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.879548e-01 0.005 0 0
Depyrimidination R-HSA-73928 9.879548e-01 0.005 0 0
ABC-family proteins mediated transport R-HSA-382556 9.882012e-01 0.005 0 0
Immune System R-HSA-168256 9.884713e-01 0.005 1 0
Proteasome assembly R-HSA-9907900 9.899092e-01 0.004 0 0
Surfactant metabolism R-HSA-5683826 9.899092e-01 0.004 0 0
Amine ligand-binding receptors R-HSA-375280 9.899092e-01 0.004 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.899092e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.899399e-01 0.004 0 0
Kidney development R-HSA-9830369 9.899399e-01 0.004 0 0
Pyruvate metabolism R-HSA-70268 9.906491e-01 0.004 0 0
Somitogenesis R-HSA-9824272 9.907642e-01 0.004 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.915468e-01 0.004 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.915468e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.920201e-01 0.003 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.922631e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.922631e-01 0.003 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.922631e-01 0.003 0 0
Downstream TCR signaling R-HSA-202424 9.924312e-01 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.924312e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.926151e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.926151e-01 0.003 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.931666e-01 0.003 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.934526e-01 0.003 0 0
Aspirin ADME R-HSA-9749641 9.936776e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.938827e-01 0.003 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.938827e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.945709e-01 0.002 0 0
Translation R-HSA-72766 9.953884e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.957214e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.957214e-01 0.002 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.958378e-01 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.958986e-01 0.002 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.965136e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.965249e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.965310e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.965560e-01 0.001 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.966197e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.968092e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.971126e-01 0.001 0 0
Interleukin-1 family signaling R-HSA-446652 9.973116e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.973274e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.974249e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.974368e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.975541e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.975541e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.975541e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.975541e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.977615e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.977615e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.977681e-01 0.001 0 0
Neddylation R-HSA-8951664 9.977738e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.978958e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.979496e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.979496e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.980299e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.981251e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.982620e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.982841e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.984260e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.985686e-01 0.001 0 0
Disease R-HSA-1643685 9.986695e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.986724e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.986848e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.986848e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.986848e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.987964e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.987964e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.989731e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.990775e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.991491e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.992275e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.992283e-01 0.000 0 0
Keratinization R-HSA-6805567 9.992395e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.993530e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.994574e-01 0.000 0 0
Interleukin-1 signaling R-HSA-9020702 9.994602e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.994810e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.995042e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.995226e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.996663e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996803e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.997089e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.997760e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998644e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998848e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998882e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998904e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999082e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999232e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999232e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999449e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999568e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999631e-01 0.000 1 0
Cardiac conduction R-HSA-5576891 9.999691e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999697e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999849e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999903e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999911e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999931e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999952e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999966e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999972e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999973e-01 0.000 1 0
Metabolism of nucleotides R-HSA-15869 9.999982e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999988e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999995e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999998e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 1 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways