CDK7

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O00115 S70 Sugiyama DNASE2 DNASE2A DNL2 QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00151 S90 Sugiyama PDLIM1 CLIM1 CLP36 IKGCTDNLtLtVARsEHKVWsPLVtEEGKRHPYKMNLASEP
O00267 S773 PSP SUPT5H SPT5 SPT5H VGsRRPGGMTsTYGRtPMYGsQtPMYGsGsRtPMYGsQtPL
O00267 S782 PSP SUPT5H SPT5 SPT5H TsTYGRtPMYGsQtPMYGsGsRtPMYGsQtPLQDGsRtPHy
O00267 T775 PSP SUPT5H SPT5 SPT5H sRRPGGMTsTYGRtPMYGsQtPMYGsGsRtPMYGsQtPLQD
O00267 T784 PSP SUPT5H SPT5 SPT5H TYGRtPMYGsQtPMYGsGsRtPMYGsQtPLQDGsRtPHyGs
O00311 S277 Sugiyama CDC7 CDC7L1 KRPYTNAQIQIKQGKDGKEGsVGLsVQRsVFGERNFNIHss
O00311 S281 Sugiyama CDC7 CDC7L1 TNAQIQIKQGKDGKEGsVGLsVQRsVFGERNFNIHssISHE
O00311 S285 Sugiyama CDC7 CDC7L1 IQIKQGKDGKEGsVGLsVQRsVFGERNFNIHssISHEsPAV
O14910 S130 Sugiyama LIN7A MALS1 VELI1 ELPKTDEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLK
O43707 T429 Sugiyama ACTN4 ERLDHLAEKFRQKAsIHEAWtDGKEAMLKHRDyEtAtLsDI
O43852 S261 Sugiyama CALU RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75821 S28 Sugiyama EIF3G EIF3S4 sKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPELL
O75821 T27 Sugiyama EIF3G EIF3S4 DsKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPEL
P02545 T19 Sugiyama LMNA LMN1 __METPsQRRAtRsGAQAsstPLsPtRItRLQEKEDLQELN
P03372 S118 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ESR1 ESR NR3A1 PPLNsVsPsPLMLLHPPPQLsPFLQPHGQQVPYYLENEPSG
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04637 S33 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TP53 P53 PLsQEtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQW
P04637 S371 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TP53 P53 KDAQAGKEPGGSRAHssHLKsKKGQstsRHKKLMFKtEGPD
P04637 S376 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TP53 P53 GKEPGGSRAHssHLKsKKGQstsRHKKLMFKtEGPDsD___
P04637 S378 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TP53 P53 EPGGSRAHssHLKsKKGQstsRHKKLMFKtEGPDsD_____
P04637 S392 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TP53 P53 KKGQstsRHKKLMFKtEGPDsD___________________
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187 S177 Sugiyama ALPP PLAP RAKKAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADVP
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05388 S304 Sugiyama RPLP0 AttAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
P05388 S307 Sugiyama RPLP0 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
P06400 S780 PSP RB1 FMQRLKtNILQyAstRPPtLsPIPHIPRsPyKFPssPLRIP
P06400 S807 PSP RB1 RsPyKFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtP
P06400 S811 PSP RB1 KFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtPRSRI
P06493 T161 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP CDK1 CDC2 CDC28A CDKN1 P34CDC2 tIKLADFGLARAFGIPIRVytHEVVTLWYRSPEVLLGsARY
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07237 T85 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P09923 S174 Sugiyama ALPI RAKQAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADMP
P10275 S516 SIGNOR|EPSD|PSP AR DHTR NR3C4 DFTAPDVWYPGGMVSRVPYPsPTCVKSEMGPWMDSYSGPyG
P10276 S77 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RARA NR1B1 SPATIETQSSSSEEIVPsPPsPPPLPRIYKPCFVCQDKSsG
P10412 S41 Sugiyama H1-4 H1F4 HIST1H1E KKKARKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAA
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11021 T69 PSP HSPA5 GRP78 RVEIIANDQGNRItPSYVAFtPEGERLIGDAAKNQLtsNPE
P11802 T172 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP CDK4 GTVKLADFGLARIYSYQMALtPVVVTLWYRAPEVLLQSTYA
P12270 S2155 Sugiyama TPR PstPtLVVPHRtDGFAEAIHsPQVAGVPRFRFGPPEDMPQT
P12814 T410 Sugiyama ACTN1 ERLDHLAEKFRQKAsIHEAWtDGKEAMLRQKDyEtAtLsEI
P13631 S77 SIGNOR|EPSD|PSP RARG NR1B3 EMASLSVETQSTSSEEMVPSsPsPPPPPRVYKPCFVCNDKS
P13631 S79 SIGNOR|EPSD|PSP RARG NR1B3 ASLSVETQSTSSEEMVPSsPsPPPPPRVYKPCFVCNDKSSG
P13639 S595 Sugiyama EEF2 EF2 PVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGLAE
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14649 S87 Sugiyama MYL6B MLC1SA EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P14859 S385 GPS6|ELM|iPTMNet|EPSD POU2F1 OCT1 OTF1 PsALNsPGIEGLSRRRKKRtsIETNIRVALEKSFLENQKPT
P14866 S101 Sugiyama HNRNPL HNRPL P/OKcl.14 GAAGGGGGGENyDDPHKtPAsPVVHIRGLIDGVVEADLVEA
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15531 S120 Sugiyama NME1 NDPKA NM23 KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P16402 S42 Sugiyama H1-3 H1F3 HIST1H1D KKAKKAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAA
P16403 S41 Sugiyama H1-2 H1F2 HIST1H1C KKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAA
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P18583 S152 Sugiyama SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312 QPEESESKtKsHDDGNIDLEsDsFLKFDsEPsAVALELPTR
P18583 S154 Sugiyama SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312 EESESKtKsHDDGNIDLEsDsFLKFDsEPsAVALELPTRAF
P18615 S138 Sugiyama NELFE RD RDBP DDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEGPGA
P18615 S140 Sugiyama NELFE RD RDBP LQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEGPGAGD
P18669 S31 Sugiyama PGAM1 PGAMA CDABP0006 HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P19447 S90 SIGNOR|PSP ERCC3 XPB XPBC DHTSRPLWVAPDGHIFLEAFsPVYKYAQDFLVAIAEPVCRP
P20042 S67 Sugiyama EIF2S2 EIF2B EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P20700 S23 Sugiyama LMNB1 LMN2 LMNB TAtPVPPRMGsRAGGPttPLsPtRLsRLQEKEELRELNDRL
P21127 S482 GPS6|EPSD CDK11B CDC2L1 CDK11 PITSLREA PK58 EIVALKRLKMEKEKEGFPITsLREINtILKAQHPNIVTVRE
P21127 T488 GPS6|EPSD CDK11B CDC2L1 CDK11 PITSLREA PK58 RLKMEKEKEGFPITsLREINtILKAQHPNIVTVREIVVGSN
P21127 T595 SIGNOR|EPSD|PSP CDK11B CDC2L1 CDK11 PITSLREA PK58 ILKVGDFGLAREyGsPLKAytPVVVtLWYRAPELLLGAKEY
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22626 S259 Sugiyama HNRNPA2B1 HNRPA2B1 GFGDGyNGyGGGPGGGNFGGsPGyGGGRGGYGGGGPGYGNQ
P23434 S153 Sugiyama GCSH LVNKSCyEDGWLIKMtLsNPsELDELMsEEAyEKYIKSIEE
P23588 T205 Sugiyama EIF4B GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR
P24928 S1616 EPSD|PSP POLR2A POLR2 TSPAYEPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNY
P24928 S1619 SIGNOR|EPSD|PSP POLR2A POLR2 AYEPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNYSPT
P24928 S1621 EPSD|PSP POLR2A POLR2 EPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNYSPTSP
P24928 S1626 SIGNOR POLR2A POLR2 GGYTPQSPSysPtsPsYsPTsPSYSPTSPNYSPTSPSYsPT
P24928 S1647 SIGNOR POLR2A POLR2 PSYSPTSPNYSPTSPSYsPTsPSYsPTsPSYSPTSPSYsPT
P24928 S1654 SIGNOR POLR2A POLR2 PNYSPTSPSYsPTsPSYsPTsPSYSPTSPSYsPTsPSYsPT
P24928 S1668 SIGNOR POLR2A POLR2 PSYsPTsPSYSPTSPSYsPTsPSYsPTsPSYSPTSPSYSPT
P24928 S1675 SIGNOR POLR2A POLR2 PSYSPTSPSYsPTsPSYsPTsPSYSPTSPSYSPTSPSYsPT
P24928 S1696 SIGNOR POLR2A POLR2 PSYSPTSPSYSPTSPSYsPTsPSYSPTSPSYSPTSPSYsPT
P24928 S1717 SIGNOR POLR2A POLR2 PSYSPTSPSYSPTSPSYsPTsPSYsPTsPSYSPTSPSYsPT
P24928 S1724 SIGNOR POLR2A POLR2 PSYSPTSPSYsPTsPSYsPTsPSYSPTSPSYsPTsPSYSPT
P24928 S1738 SIGNOR POLR2A POLR2 PSYsPTsPSYSPTSPSYsPTsPSYSPTSPNYSPTSPNYTPT
P24928 S1766 SIGNOR POLR2A POLR2 PNYSPTSPNYTPTSPSYsPTsPSYSPTSPNYTPTSPNYsPT
P24928 S1787 SIGNOR POLR2A POLR2 PSYSPTSPNYTPTSPNYsPTsPSYSPTSPSYSPTSPSYSPS
P24928 S1864 SIGNOR POLR2A POLR2 PsysPssPEytPtsPKysPtsPKysPtsPKysPtsPtysPt
P24928 S1871 SIGNOR POLR2A POLR2 PEytPtsPKysPtsPKysPtsPKysPtsPtysPttPKysPt
P24928 S1878 EPSD|PSP POLR2A POLR2 PKysPtsPKysPtsPKysPtsPtysPttPKysPtsPtysPt
P24928 S1882 SIGNOR POLR2A POLR2 PtsPKysPtsPKysPtsPtysPttPKysPtsPtysPtsPVy
P24928 S1892 SIGNOR POLR2A POLR2 PKysPtsPtysPttPKysPtsPtysPtsPVytPtsPKysPt
P24928 S1899 SIGNOR POLR2A POLR2 PtysPttPKysPtsPtysPtsPVytPtsPKysPtsPtysPt
P24928 S1913 SIGNOR POLR2A POLR2 PtysPtsPVytPtsPKysPtsPtysPtsPKysPtsPtysPt
P24928 S1920 SIGNOR|Sugiyama POLR2A POLR2 PVytPtsPKysPtsPtysPtsPKysPtsPtysPtsPKGstY
P24928 S1927 SIGNOR POLR2A POLR2 PKysPtsPtysPtsPKysPtsPtysPtsPKGstYsPtsPGY
P24928 S1934 SIGNOR POLR2A POLR2 PtysPtsPKysPtsPtysPtsPKGstYsPtsPGYsPtsPTY
P24928 S1944 SIGNOR POLR2A POLR2 sPtsPtysPtsPKGstYsPtsPGYsPtsPTYSLTsPAIsPD
P24928 S1951 SIGNOR POLR2A POLR2 sPtsPKGstYsPtsPGYsPtsPTYSLTsPAIsPDDsDEEN_
P24928 T1919 Sugiyama POLR2A POLR2 sPVytPtsPKysPtsPtysPtsPKysPtsPtysPtsPKGst
P24928 Y1909 Sugiyama POLR2A POLR2 sPtsPtysPtsPVytPtsPKysPtsPtysPtsPKysPtsPt
P24941 S46 EPSD|PSP CDK2 CDKN2 TGEVVALKKIRLDtETEGVPstAIREIsLLKELNHPNIVKL
P24941 T160 GPS6|SIGNOR|iPTMNet|EPSD|PSP CDK2 CDKN2 AIKLADFGLARAFGVPVRtytHEVVtLWyRAPEILLGCKYY
P24941 T165 EPSD|PSP CDK2 CDKN2 DFGLARAFGVPVRtytHEVVtLWyRAPEILLGCKYYSTAVD
P24941 Y168 EPSD|PSP CDK2 CDKN2 LARAFGVPVRtytHEVVtLWyRAPEILLGCKYYSTAVDIWS
P25786 S14 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26196 S475 Sugiyama DDX6 HLR2 RCK TEIKPIPsNIDKSLyVAEyHsEPVEDEKP____________
P26885 S108 Sugiyama FKBP2 FKBP13 GWDQGLLGMCEGEKRKLVIPsELGyGERGAPPKIPGGATLV
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27824 S583 Sugiyama CANX VsQEEEDRKPKAEEDEILNRsPRNRKPRRE___________
P29474 S1177 GPS6 NOS3 EDIFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPG
P29474 S633 GPS6 NOS3 FNsISCSDPLVssWRRKRKEssNtDSAGALGTLRFCVFGLG
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30086 S104 Sugiyama PEBP1 PBP PEBP WHHFLVVNMKGNDIssGtVLsDyVGsGPPKGtGLHRyVWLV
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32969 S182 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 QQATTVKNKDIRKFLDGIyVsEKGtVQQADE__________
P35241 S532 Sugiyama RDX EERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35579 T1904 Sugiyama MYH9 EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776 S139 Sugiyama RPL27A KQPVIVKAKFFSRRAEEKIKsVGGACVLVA___________
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777 T177 Sugiyama RPL5 MSTP030 NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P49736 S108 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 DAYEAEGLALDDEDVEELtAsQREAAERAMRQRDREAGRGL
P49736 S13 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 ________MAEssEsFtMAssPAQRRRGNDPLtssPGRssR
P49736 S139 SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 QRDREAGRGLGRMRRGLLyDsDEEDEERPARKRRQVERAtE
P49736 S27 SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 sFtMAssPAQRRRGNDPLtssPGRssRRtDALtssPGRDLP
P49736 S4 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 _________________MAEssEsFtMAssPAQRRRGNDPL
P49736 S40 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 GNDPLtssPGRssRRtDALtssPGRDLPPFEDEsEGLLGtE
P49736 S41 SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 NDPLtssPGRssRRtDALtssPGRDLPPFEDEsEGLLGtEG
P49736 S5 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 ________________MAEssEsFtMAssPAQRRRGNDPLt
P49736 S53 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 RRtDALtssPGRDLPPFEDEsEGLLGtEGPLEEEEDGEELI
P49736 S7 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 ______________MAEssEsFtMAssPAQRRRGNDPLtss
P49736 T59 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 tssPGRDLPPFEDEsEGLLGtEGPLEEEEDGEELIGDGMER
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50613 S164 GPS6|ELM|iPTMNet|EPSD|Sugiyama CDK7 CAK CAK1 CDKN7 MO15 STK1 LLDENGVLKLADFGLAKsFGsPNRAytHQVVtRWYRAPELL
P50613 S321 Sugiyama CDK7 CAK CAK1 CDKN7 MO15 STK1 PtPGCQLPRPNCPVETLKEQsNPALAIKRKRTEALEQGGLP
P50613 T170 GPS6|ELM|iPTMNet|EPSD|Sugiyama CDK7 CAK CAK1 CDKN7 MO15 STK1 VLKLADFGLAKsFGsPNRAytHQVVtRWYRAPELLFGARMY
P50613 Y169 Sugiyama CDK7 CAK CAK1 CDKN7 MO15 STK1 GVLKLADFGLAKsFGsPNRAytHQVVtRWYRAPELLFGARM
P50750 S175 EPSD|PSP CDK9 CDC2L4 TAK VLITRDGVLKLADFGLARAFsLAKNSQPNRytNRVVTLWYR
P51946 S322 Sugiyama CCNH YVsKKSKHEEEEWtDDDLVEsL___________________
P51946 T315 Sugiyama CCNH KGYEDDDYVsKKSKHEEEEWtDDDLVEsL____________
P51948 S279 Sugiyama MNAT1 CAP35 MAT1 RNF66 HVPELEMLGRLGYLNHVRAAsPQDLAGGYTSSLACHRALQD
P51948 T67 Sugiyama MNAT1 CAP35 MAT1 RNF66 PECGtPLRKSNFRVQLFEDPtVDKEVEIRKKVLKIYNKREE
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P60660 S30 Sugiyama MYL6 AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61978 S284 Sugiyama HNRNPK HNRPK MPPGRGGRPMPPSRRDyDDMsPRRGPPPPPPGRGGRGGsRA
P61978 Y72 Sugiyama HNRNPK HNRPK KNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISA
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62942 S9 Sugiyama FKBP1A FKBP1 FKBP12 ____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q00534 T177 EPSD|PSP CDK6 CDKN6 GQIKLADFGLARIYSFQMALtSVVVTLWYRAPEVLLQSSYA
Q01094 S403 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP E2F1 RBBP3 LLEHVREDFSGLLPEEFISLsPPHEALDYHFGLEEGEGIRD
Q01094 T433 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP E2F1 RBBP3 FGLEEGEGIRDLFDCDFGDLtPLDF________________
Q01130 S208 Sugiyama SRSF2 SFRS2 RsRsPPPVsKRESKSRSRsKsPPKsPEEEGAVss_______
Q01860 S12 SIGNOR|PSP POU5F1 OCT3 OCT4 OTF3 _________MAGHLASDFAFsPPPGGGGDGPGGPEPGWVDP
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07021 S213 Sugiyama C1QBP GC1QBP HABP1 SF2P32 VGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDSLDW
Q07960 S50 Sugiyama ARHGAP1 CDC42GAP RHOGAP1 EKNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARH
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q13283 S231 Sugiyama G3BP1 G3BP QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13285 S203 GPS6|SIGNOR|EPSD|PSP NR5A1 AD4BP FTZF1 SF1 YLYPAFPGRAIKSEYPEPYAsPPQPGLPYGYPEPFSGGPNV
Q14103 S190 Sugiyama HNRNPD AUF1 HNRPD KRAKAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVES
Q14247 S405 Sugiyama CTTN EMS1 EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14257 S298 Sugiyama RCN2 ERC55 NGDKKLsEEEILENPDLFLtsEAtDyGRQLHDDyFyHDEL_
Q14847 S146 GPS6|ELM|iPTMNet|EPSD LASP1 MLN50 FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15648 T1457 PSP MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2 sGstPKHERGsPsHsKsPAytPQNLDsEsEsGSSIAEKsyQ
Q15797 S206 EPSD|PSP SMAD1 BSP1 MADH1 MADR1 HsPNSSYPNsPGSSSStYPHsPTSSDPGsPFQMPADTPPPA
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q6PKG0 S627 Sugiyama LARP1 KIAA0731 LARP FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6PKG0 S631 Sugiyama LARP1 KIAA0731 LARP EEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPH
Q6PKG0 S774 Sugiyama LARP1 KIAA0731 LARP LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q6PKG0 Y633 Sugiyama LARP1 KIAA0731 LARP MEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPHyM
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q7Z417 S692 Sugiyama NUFIP2 KIAA1321 PIG1 IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q8N543 S256 PSP OGFOD1 KIAA1612 TPA1 WFHGPSLTRPPNYFEPPIPRsPHIPQDHEILYDWINPTYLD
Q8NBJ5 S612 Sugiyama COLGALT1 GLT25D1 PSEC0241 QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NHW5 S304 Sugiyama RPLP0P6 DTTAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
Q8NHW5 S307 Sugiyama RPLP0P6 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TC07 S675 Sugiyama TBC1D15 TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q99614 S89 Sugiyama TTC1 TPR1 sFEEEPGADKVENKsNEDVNssELDEEyLIELEKNMSDEEK
Q99614 S90 Sugiyama TTC1 TPR1 FEEEPGADKVENKsNEDVNssELDEEyLIELEKNMSDEEKQ
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BYE7 S30 SIGNOR|iPTMNet|EPSD|PSP PCGF6 MBLR RNF134 GSVGAAKTEGAAALPPPPPVsPPALTPAPAAGEEGPAPLSE
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9H0B6 S445 Sugiyama KLC2 RRDsAPyGEyGsWYKACKVDsPtVNTTLRSLGALYRRQGKL
Q9H0D6 T439 SIGNOR|EPSD|PSP XRN2 KEKRKRMKRDQPAFtPsGILtPHALGsRNsPGsQVAsNPRQ
Q9H1E3 S113 Sugiyama NUCKS1 NUCKS JC7 RQAASKAASKQREMLMEDVGsEEEQEEEDEAPFQEKDsGsD
Q9H4A3 S1261 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H773 S85 Sugiyama DCTPP1 XTP3TPA CDA03 GELAELFQWKTDGEPGPQGWsPRERAALQEELSDVLIYLVA
Q9HAP6 S115 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 ELPKTDEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLK
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NUP9 S115 Sugiyama LIN7C MALS3 VELI3 ELPKTEEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLK
Q9NUQ3 S97 Sugiyama TXLNG CXorf15 ELRG LSR5 KHSLEEDEGsDFItENRNLVsPAyCtQEsREEIPGGEARTD
Q9NYV4 T893 SIGNOR|EPSD|PSP CDK12 CRK7 CRKRS KIAA0904 IKLADFGLARLYNsEEsRPYtNKVITLWYRPPELLLGEERY
Q9NZB2 T991 Sugiyama FAM120A C9orf10 KIAA0183 OSSA PLQVVSVGGPARGRPRGVIstPVIRTFGRGGRYYGRGYKNQ
Q9UBU7 S282 Sugiyama DBF4 ASK DBF4A ZDBF1 QKQTQVKLRIQtDGDKYGGtsIQLQLKEKKKKGYCECCLQK
Q9UBU7 S312 Sugiyama DBF4 ASK DBF4A ZDBF1 KKGYCECCLQKYEDLEtHLLsEQHRNFAQSNQYQVVDDIVS
Q9UBU7 S508 Sugiyama DBF4 ASK DBF4A ZDBF1 ASVHVSDFSTDNSGsQPKQKsDtVLFPAKDLKEKDLHSIFT
Q9UBU7 T281 Sugiyama DBF4 ASK DBF4A ZDBF1 MQKQTQVKLRIQtDGDKYGGtsIQLQLKEKKKKGYCECCLQ
Q9UBU7 T308 Sugiyama DBF4 ASK DBF4A ZDBF1 KEKKKKGYCECCLQKYEDLEtHLLsEQHRNFAQSNQYQVVD
Q9UBU7 T390 Sugiyama DBF4 ASK DBF4A ZDBF1 EQKEKVELQHIsQKDCQEDDttVKEQNFLYKETQETEKKLL
Q9UBU7 T391 Sugiyama DBF4 ASK DBF4A ZDBF1 QKEKVELQHIsQKDCQEDDttVKEQNFLYKETQETEKKLLF
Q9UBU7 T510 Sugiyama DBF4 ASK DBF4A ZDBF1 VHVSDFSTDNSGsQPKQKsDtVLFPAKDLKEKDLHSIFTHD
Q9UBU7 T553 Sugiyama DBF4 ASK DBF4A ZDBF1 LITINSsQEHLTVQAKAPFHtPPEEPNECDFKNMDSLPsGK
Q9UPR0 T584 Sugiyama PLCL2 KIAA1092 PLCE2 KILIKAKKLsSNCSGVEGDVtDEDEGAEMSQRMGKENMEQP
Q9UPZ9 T157 GPS6|ELM|iPTMNet|EPSD CILK1 ICK KIAA0936 ELVKIADFGLAREIRSKPPYtDyVsTRWYRAPEVLLRSTNY
Q9UQ35 S2398 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ANLtsPRVPLsAyERVsGRtsPPLLDRARsRtPPsAPsQsR
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2W1 S240 Sugiyama THRAP3 BCLAF2 TRAP150 sKPWPDAtyGtGsAsRAsAVsELsPRERsPALKsPLQsVVV
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 0.000001 5.925 0 0
Cardiogenesis R-HSA-9733709 0.000004 5.396 0 0
Chromatin modifying enzymes R-HSA-3247509 0.000007 5.128 0 0
NRAGE signals death through JNK R-HSA-193648 0.000007 5.133 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.000054 4.271 0 0
Death Receptor Signaling R-HSA-73887 0.000058 4.234 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.000085 4.073 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.000114 3.941 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.000131 3.882 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.000177 3.753 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.000227 3.643 0 0
Adipogenesis R-HSA-9843745 0.000247 3.608 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.000388 3.411 0 0
G alpha (12/13) signalling events R-HSA-416482 0.000484 3.315 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.000654 3.184 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.000688 3.162 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.000859 3.066 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.001063 2.973 0 0
Circadian clock R-HSA-9909396 0.001118 2.951 0 0
Notch-HLH transcription pathway R-HSA-350054 0.001640 2.785 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.001621 2.790 0 0
G1/S-Specific Transcription R-HSA-69205 0.001594 2.798 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.001825 2.739 0 0
Cell Cycle R-HSA-1640170 0.001838 2.736 1 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.001941 2.712 0 0
Cell Cycle, Mitotic R-HSA-69278 0.002108 2.676 1 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.002410 2.618 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.002604 2.584 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.002514 2.600 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.002501 2.602 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.002825 2.549 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.002825 2.549 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.003250 2.488 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.003188 2.496 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.003188 2.496 0 0
Nuclear import of Rev protein R-HSA-180746 0.003057 2.515 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.003094 2.510 0 0
HDMs demethylate histones R-HSA-3214842 0.003368 2.473 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.003377 2.471 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.003436 2.464 1 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.003692 2.433 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.003692 2.433 0 0
Formation of axial mesoderm R-HSA-9796292 0.003692 2.433 0 0
Gastrulation R-HSA-9758941 0.003608 2.443 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.003962 2.402 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.003975 2.401 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.003975 2.401 0 0
RUNX2 regulates bone development R-HSA-8941326 0.004428 2.354 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.005006 2.301 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.005473 2.262 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.005596 2.252 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.005811 2.236 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.005811 2.236 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.006123 2.213 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.006123 2.213 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.006643 2.178 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.006950 2.158 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.007516 2.124 0 0
Formation of definitive endoderm R-HSA-9823730 0.008632 2.064 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.008623 2.064 0 0
Signaling by NOTCH1 R-HSA-1980143 0.008932 2.049 0 0
Regulation of TP53 Activity R-HSA-5633007 0.008719 2.060 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.008623 2.064 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.008623 2.064 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.007977 2.098 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.008623 2.064 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.009808 2.008 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.010046 1.998 0 0
Signaling by NTRKs R-HSA-166520 0.010120 1.995 0 0
Repression of WNT target genes R-HSA-4641265 0.010687 1.971 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.011114 1.954 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.012635 1.898 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.012635 1.898 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.012635 1.898 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.012635 1.898 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.012635 1.898 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.012635 1.898 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 0.013764 1.861 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 0.013764 1.861 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.013764 1.861 0 0
NGF-stimulated transcription R-HSA-9031628 0.013308 1.876 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.013332 1.875 0 0
Signaling by Hippo R-HSA-2028269 0.013936 1.856 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.014008 1.854 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.015155 1.819 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.015464 1.811 0 0
Heme signaling R-HSA-9707616 0.015944 1.797 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.017841 1.749 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.018669 1.729 0 0
Mitotic Prometaphase R-HSA-68877 0.020143 1.696 0 0
M Phase R-HSA-68886 0.022539 1.647 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.022879 1.641 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.023309 1.632 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.023700 1.625 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.024518 1.611 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.025367 1.596 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.025428 1.595 0 0
TGFBR3 expression R-HSA-9839394 0.027125 1.567 0 0
RET signaling R-HSA-8853659 0.027283 1.564 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.028130 1.551 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.028229 1.549 0 0
MECP2 regulates transcription factors R-HSA-9022707 0.028229 1.549 0 0
HCN channels R-HSA-1296061 0.031725 1.499 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.031725 1.499 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.030773 1.512 0 0
G0 and Early G1 R-HSA-1538133 0.031788 1.498 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.031251 1.505 0 0
tRNA processing in the nucleus R-HSA-6784531 0.031934 1.496 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.034001 1.469 0 0
TNF signaling R-HSA-75893 0.034001 1.469 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.034380 1.464 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 0.037903 1.421 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.037903 1.421 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.037903 1.421 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.038635 1.413 0 0
Mitotic Prophase R-HSA-68875 0.036083 1.443 0 0
Nuclear RNA decay R-HSA-9930044 0.036476 1.438 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.040303 1.395 0 0
Specification of primordial germ cells R-HSA-9827857 0.041463 1.382 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.041603 1.381 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.042623 1.370 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.042700 1.370 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.046213 1.335 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.046213 1.335 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.046213 1.335 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.046431 1.333 0 0
IRS activation R-HSA-74713 0.046431 1.333 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.046431 1.333 0 0
RAF activation R-HSA-5673000 0.047223 1.326 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.047223 1.326 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.047486 1.323 0 0
Apoptotic execution phase R-HSA-75153 0.047486 1.323 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.047486 1.323 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.049251 1.308 0 0
Polo-like kinase mediated events R-HSA-156711 0.049402 1.306 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.049402 1.306 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.049928 1.302 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.051321 1.290 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.055588 1.255 0 0
Cellular response to heat stress R-HSA-3371556 0.061807 1.209 0 0
Signal attenuation R-HSA-74749 0.062264 1.206 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.062585 1.204 1 1
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.076378 1.117 0 0
Regulation of TP53 Expression R-HSA-6804754 0.076378 1.117 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.076378 1.117 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.076378 1.117 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.076378 1.117 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.076378 1.117 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.076378 1.117 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.076378 1.117 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.076378 1.117 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.076378 1.117 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.076378 1.117 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.076378 1.117 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.063913 1.194 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 0.063913 1.194 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.063913 1.194 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.067904 1.168 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.078474 1.105 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.071286 1.147 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.077394 1.111 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.071286 1.147 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.063805 1.195 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.066959 1.174 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.063913 1.194 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.071276 1.147 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.071951 1.143 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.067432 1.171 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.066134 1.180 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.066134 1.180 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.075296 1.123 0 0
HIV Life Cycle R-HSA-162587 0.071214 1.147 1 0
Deubiquitination R-HSA-5688426 0.070227 1.153 0 0
Cell Cycle Checkpoints R-HSA-69620 0.079229 1.101 0 0
Inositol phosphate metabolism R-HSA-1483249 0.077907 1.108 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.071286 1.147 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.079778 1.098 0 0
Prolonged ERK activation events R-HSA-169893 0.079778 1.098 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.079778 1.098 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.079897 1.097 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.079897 1.097 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.079897 1.097 0 0
HATs acetylate histones R-HSA-3214847 0.081906 1.087 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.082619 1.083 0 0
snRNP Assembly R-HSA-191859 0.084387 1.074 0 0
Metabolism of non-coding RNA R-HSA-194441 0.084387 1.074 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 0.107150 0.970 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 0.107150 0.970 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 0.107150 0.970 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.107150 0.970 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 0.107150 0.970 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.202824 0.693 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.202824 0.693 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.202824 0.693 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.202824 0.693 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.202824 0.693 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 0.111030 0.955 0 0
MET interacts with TNS proteins R-HSA-8875513 0.111030 0.955 0 0
Invadopodia formation R-HSA-8941237 0.111030 0.955 0 0
Regulation of gap junction activity R-HSA-191650 0.148862 0.827 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.148862 0.827 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 0.148862 0.827 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.148862 0.827 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 0.288251 0.540 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 0.288251 0.540 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 0.288251 0.540 0 0
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) R-HSA-5619096 0.288251 0.540 0 0
Defective VWF binding to collagen type I R-HSA-9845622 0.288251 0.540 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 0.288251 0.540 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 0.288251 0.540 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 0.288251 0.540 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 0.288251 0.540 0 0
Regulation of PTEN localization R-HSA-8948747 0.106330 0.973 0 0
PTK6 Expression R-HSA-8849473 0.106330 0.973 0 0
SOS-mediated signalling R-HSA-112412 0.106330 0.973 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.106330 0.973 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.130728 0.884 0 0
MET receptor recycling R-HSA-8875656 0.130728 0.884 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.093098 1.031 0 0
Signaling by AXIN mutants R-HSA-4839735 0.093098 1.031 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.093098 1.031 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 0.110763 0.956 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 0.110763 0.956 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.156863 0.804 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.156863 0.804 0 0
ALK mutants bind TKIs R-HSA-9700645 0.156863 0.804 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.229948 0.638 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.229948 0.638 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.229948 0.638 0 0
Signaling by RNF43 mutants R-HSA-5340588 0.229948 0.638 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 0.364528 0.438 0 0
Defective ABCD1 causes ALD R-HSA-5684045 0.364528 0.438 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 0.364528 0.438 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 0.364528 0.438 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 0.364528 0.438 0 0
Defective F8 sulfation at Y1699 R-HSA-9674519 0.364528 0.438 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 0.364528 0.438 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.184435 0.734 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.089916 1.046 0 0
G2/M DNA replication checkpoint R-HSA-69478 0.271599 0.566 0 0
Signaling by APC mutants R-HSA-4839744 0.213154 0.671 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.213154 0.671 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.213154 0.671 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.213154 0.671 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.139938 0.854 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.157407 0.803 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.157407 0.803 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.157407 0.803 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.157407 0.803 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.242738 0.615 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.242738 0.615 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.313169 0.504 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.313169 0.504 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 0.313169 0.504 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 0.432635 0.364 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 0.432635 0.364 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 0.432635 0.364 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 0.432635 0.364 0 0
Classical Kir channels R-HSA-1296053 0.432635 0.364 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.432635 0.364 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.432635 0.364 0 0
MET activates PTPN11 R-HSA-8865999 0.432635 0.364 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.217021 0.663 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.217021 0.663 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.159380 0.798 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.272925 0.564 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.272925 0.564 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.272925 0.564 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.272925 0.564 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.272925 0.564 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.272925 0.564 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.272925 0.564 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.272925 0.564 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.272925 0.564 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.194780 0.710 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.175477 0.756 0 0
Type I hemidesmosome assembly R-HSA-446107 0.354199 0.451 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.354199 0.451 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.354199 0.451 0 0
Formation of annular gap junctions R-HSA-196025 0.354199 0.451 0 0
FGFR3 mutant receptor activation R-HSA-2033514 0.303471 0.518 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.303471 0.518 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 0.303471 0.518 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.303471 0.518 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.265386 0.576 0 0
Ephrin signaling R-HSA-3928664 0.265386 0.576 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.234864 0.629 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.165056 0.782 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.165056 0.782 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.165056 0.782 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.290274 0.537 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.334153 0.476 0 0
ARMS-mediated activation R-HSA-170984 0.394326 0.404 0 0
Gap junction degradation R-HSA-190873 0.394326 0.404 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.493446 0.307 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 0.493446 0.307 0 0
Signaling by LRP5 mutants R-HSA-5339717 0.493446 0.307 0 0
Signaling by MAP2K mutants R-HSA-9652169 0.493446 0.307 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.493446 0.307 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.493446 0.307 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 0.493446 0.307 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.196867 0.706 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.141334 0.850 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.276984 0.558 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.190208 0.721 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.235664 0.628 0 0
Erythropoietin activates RAS R-HSA-9027284 0.364770 0.438 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.364770 0.438 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.340809 0.467 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.433273 0.363 0 0
MAPK3 (ERK1) activation R-HSA-110056 0.433273 0.363 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.433273 0.363 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.320461 0.494 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.320461 0.494 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.150147 0.823 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.123522 0.908 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.123522 0.908 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.123522 0.908 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 0.395145 0.403 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 0.395145 0.403 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.194826 0.710 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.286816 0.542 1 1
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.214330 0.669 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.366217 0.436 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.366217 0.436 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.216213 0.665 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.260998 0.583 0 0
Centrosome maturation R-HSA-380287 0.237693 0.624 0 0
Separation of Sister Chromatids R-HSA-2467813 0.141022 0.851 0 0
MAP2K and MAPK activation R-HSA-5674135 0.322252 0.492 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.322252 0.492 1 1
HIV Transcription Initiation R-HSA-167161 0.322252 0.492 1 1
RNA Polymerase II Transcription Initiation R-HSA-75953 0.322252 0.492 1 1
Downstream signaling of activated FGFR3 R-HSA-5654708 0.364641 0.438 0 0
Late endosomal microautophagy R-HSA-9615710 0.364641 0.438 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.364641 0.438 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.391570 0.407 0 0
FGFR2 alternative splicing R-HSA-6803529 0.391570 0.407 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.470832 0.327 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.470832 0.327 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 0.547742 0.261 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 0.547742 0.261 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 0.547742 0.261 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 0.547742 0.261 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 0.547742 0.261 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 0.547742 0.261 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.547742 0.261 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 0.547742 0.261 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.288916 0.539 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.288916 0.539 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.288916 0.539 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.361793 0.442 0 0
Activation of the pre-replicative complex R-HSA-68962 0.386803 0.413 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.358349 0.446 1 1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.454560 0.342 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 0.454560 0.342 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.310236 0.508 0 0
mRNA 3'-end processing R-HSA-72187 0.371455 0.430 0 0
Deadenylation of mRNA R-HSA-429947 0.441722 0.355 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.506854 0.295 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.394766 0.404 1 1
RNA Polymerase III Transcription Termination R-HSA-73980 0.483349 0.316 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.412993 0.384 0 0
PPARA activates gene expression R-HSA-1989781 0.322764 0.491 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.259936 0.585 0 0
Translesion Synthesis by POLH R-HSA-110320 0.511390 0.291 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.511390 0.291 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.511390 0.291 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.541236 0.267 0 0
Polymerase switching R-HSA-69091 0.541236 0.267 0 0
Leading Strand Synthesis R-HSA-69109 0.541236 0.267 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.596221 0.225 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 0.596221 0.225 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.596221 0.225 0 0
PKB-mediated events R-HSA-109703 0.596221 0.225 0 0
PDE3B signalling R-HSA-165160 0.596221 0.225 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.596221 0.225 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 0.596221 0.225 0 0
Phosphorylation of Emi1 R-HSA-176417 0.596221 0.225 0 0
Signaling by MAPK mutants R-HSA-9652817 0.596221 0.225 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.537544 0.270 1 1
Formation of the Early Elongation Complex R-HSA-113418 0.537544 0.270 1 1
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.508059 0.294 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.510254 0.292 1 1
Lagging Strand Synthesis R-HSA-69186 0.564927 0.248 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.564927 0.248 0 0
Signaling by Erythropoietin R-HSA-9006335 0.560195 0.252 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.560195 0.252 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.582229 0.235 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.590310 0.229 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 0.604865 0.218 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.639507 0.194 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 0.639507 0.194 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.639507 0.194 0 0
Autointegration results in viral DNA circles R-HSA-177539 0.639507 0.194 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.639507 0.194 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 0.639507 0.194 0 0
Trafficking of AMPA receptors R-HSA-399719 0.603613 0.219 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.614716 0.211 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.614716 0.211 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.634077 0.198 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.634077 0.198 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.634077 0.198 0 0
Translesion synthesis by REV1 R-HSA-110312 0.634077 0.198 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.634077 0.198 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.634077 0.198 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.638120 0.195 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.638120 0.195 1 1
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.638120 0.195 1 1
Termination of O-glycan biosynthesis R-HSA-977068 0.638120 0.195 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.649973 0.187 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.668237 0.175 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.660510 0.180 0 0
Translesion synthesis by POLI R-HSA-5656121 0.661570 0.179 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.661570 0.179 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 0.678154 0.169 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.678154 0.169 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.678154 0.169 0 0
Disinhibition of SNARE formation R-HSA-114516 0.678154 0.169 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 0.678154 0.169 0 0
FGFR3b ligand binding and activation R-HSA-190371 0.678154 0.169 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.687375 0.163 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.687375 0.163 0 0
Translesion synthesis by POLK R-HSA-5655862 0.687375 0.163 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.687375 0.163 0 0
PTEN Regulation R-HSA-6807070 0.320422 0.494 0 0
Transcription of the HIV genome R-HSA-167172 0.492617 0.307 1 1
MITF-M-dependent gene expression R-HSA-9856651 0.355847 0.449 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.565287 0.248 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.460880 0.336 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.196987 0.706 0 0
RNA Polymerase III Transcription R-HSA-74158 0.361793 0.442 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.265776 0.575 0 0
Signaling by NOTCH3 R-HSA-9012852 0.108332 0.965 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.217021 0.663 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.252389 0.598 0 0
DNA Damage Bypass R-HSA-73893 0.467293 0.330 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.173005 0.762 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.391570 0.407 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.386803 0.413 0 0
Crosslinking of collagen fibrils R-HSA-2243919 0.511390 0.291 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.512252 0.291 1 1
MITF-M-regulated melanocyte development R-HSA-9730414 0.558300 0.253 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.255712 0.592 0 0
Signaling by ERBB2 R-HSA-1227986 0.649973 0.187 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.272925 0.564 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.560195 0.252 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.635727 0.197 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.196867 0.706 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.515802 0.288 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.265386 0.576 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.153109 0.815 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.391465 0.407 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.334153 0.476 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.320461 0.494 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.366217 0.436 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.582229 0.235 0 0
Frs2-mediated activation R-HSA-170968 0.129793 0.887 0 0
Neurexins and neuroligins R-HSA-6794361 0.149421 0.826 0 0
Formation of the posterior neural plate R-HSA-9832991 0.213154 0.671 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.098909 1.005 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.537977 0.269 0 0
Interleukin-15 signaling R-HSA-8983432 0.272925 0.564 0 0
Signaling by BMP R-HSA-201451 0.514318 0.289 0 0
DAP12 signaling R-HSA-2424491 0.582229 0.235 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.217021 0.663 0 0
Mitotic Anaphase R-HSA-68882 0.097414 1.011 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.171884 0.765 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.229948 0.638 0 0
Formation of lateral plate mesoderm R-HSA-9758920 0.229948 0.638 0 0
PI3K/AKT activation R-HSA-198203 0.184435 0.734 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.175477 0.756 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.158598 0.800 0 0
Insulin receptor signalling cascade R-HSA-74751 0.123330 0.909 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.128585 0.891 0 0
Signaling by Activin R-HSA-1502540 0.364770 0.438 0 0
Homology Directed Repair R-HSA-5693538 0.176834 0.752 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.425120 0.371 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 0.596221 0.225 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.480945 0.318 1 0
Fanconi Anemia Pathway R-HSA-6783310 0.555653 0.255 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.614716 0.211 0 0
Signaling by NOTCH R-HSA-157118 0.485530 0.314 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.101425 0.994 0 0
RNA Polymerase I Transcription R-HSA-73864 0.510254 0.292 1 0
IRS-mediated signalling R-HSA-112399 0.126135 0.899 0 0
Signaling by RAS mutants R-HSA-6802949 0.165056 0.782 0 0
DNA Double Strand Break Response R-HSA-5693606 0.614852 0.211 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.173005 0.762 0 0
p75NTR signals via NF-kB R-HSA-193639 0.364770 0.438 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.489164 0.311 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.174456 0.758 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.174456 0.758 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.192535 0.715 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.582735 0.235 1 1
Transcriptional Regulation by TP53 R-HSA-3700989 0.268164 0.572 1 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.093098 1.031 0 0
Activation of RAC1 R-HSA-428540 0.093098 1.031 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.110763 0.956 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.093245 1.030 0 0
CREB phosphorylation R-HSA-199920 0.271599 0.566 0 0
Adrenoceptors R-HSA-390696 0.354199 0.451 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.158598 0.800 0 0
Interleukin-6 signaling R-HSA-1059683 0.303471 0.518 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.265386 0.576 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.394326 0.404 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.493446 0.307 0 0
Signaling by WNT in cancer R-HSA-4791275 0.264307 0.578 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.320461 0.494 1 1
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.299871 0.523 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.634077 0.198 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 0.678154 0.169 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.682176 0.166 0 0
Signaling by FGFR3 R-HSA-5654741 0.555653 0.255 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.570095 0.244 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.614716 0.211 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.489164 0.311 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.290274 0.537 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.177399 0.751 0 0
Mitochondrial biogenesis R-HSA-1592230 0.168983 0.772 0 0
ERK/MAPK targets R-HSA-198753 0.175714 0.755 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.131695 0.880 0 0
Integration of provirus R-HSA-162592 0.506854 0.295 0 0
Long-term potentiation R-HSA-9620244 0.466345 0.331 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.406424 0.391 0 0
Regulation of signaling by CBL R-HSA-912631 0.511390 0.291 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.541236 0.267 0 0
IGF1R signaling cascade R-HSA-2428924 0.123330 0.909 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.538489 0.269 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.447285 0.349 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.245615 0.610 0 0
Signaling by NOTCH2 R-HSA-1980145 0.495641 0.305 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.307512 0.512 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.188796 0.724 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.242738 0.615 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.175714 0.755 0 0
PI3K Cascade R-HSA-109704 0.128609 0.891 0 0
Calcineurin activates NFAT R-HSA-2025928 0.394326 0.404 0 0
MET promotes cell motility R-HSA-8875878 0.252389 0.598 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.433273 0.363 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.105952 0.975 1 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.302672 0.519 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.452742 0.344 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.541236 0.267 0 0
Signaling by NODAL R-HSA-1181150 0.538604 0.269 0 0
FGFR3 ligand binding and activation R-HSA-190239 0.634077 0.198 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 0.678154 0.169 0 0
Laminin interactions R-HSA-3000157 0.681878 0.166 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.681878 0.166 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.554842 0.256 0 0
Signalling to ERKs R-HSA-187687 0.203405 0.692 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.109657 0.960 0 0
Nucleotide Excision Repair R-HSA-5696398 0.673479 0.172 1 0
Interleukin-6 family signaling R-HSA-6783589 0.441722 0.355 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.158598 0.800 0 0
Cilium Assembly R-HSA-5617833 0.584501 0.233 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.171452 0.766 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.255712 0.592 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.132163 0.879 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.346870 0.460 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.541236 0.267 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.170627 0.768 0 0
MTOR signalling R-HSA-165159 0.499583 0.301 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.435946 0.361 0 0
Signaling by TGFB family members R-HSA-9006936 0.165368 0.782 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.492766 0.307 1 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.490566 0.309 0 0
Gene expression (Transcription) R-HSA-74160 0.101567 0.993 1 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.148862 0.827 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.148862 0.827 0 0
Signaling by LTK R-HSA-9842663 0.110763 0.956 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.102212 0.990 0 0
Inhibition of nitric oxide production R-HSA-9636249 0.432635 0.364 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.334153 0.476 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 0.506854 0.295 0 0
MET activates RAS signaling R-HSA-8851805 0.541236 0.267 0 0
HDACs deacetylate histones R-HSA-3214815 0.571256 0.243 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.510282 0.292 0 0
RNA Polymerase II Transcription R-HSA-73857 0.345317 0.462 1 0
Signaling by Insulin receptor R-HSA-74752 0.487481 0.312 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.524483 0.280 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.521891 0.282 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.614716 0.211 0 0
Oncogene Induced Senescence R-HSA-2559585 0.516615 0.287 0 0
Developmental Biology R-HSA-1266738 0.624119 0.205 0 0
Ub-specific processing proteases R-HSA-5689880 0.594340 0.226 0 0
DNA Repair R-HSA-73894 0.198889 0.701 1 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.271599 0.566 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.100304 0.999 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.375123 0.426 0 0
Rap1 signalling R-HSA-392517 0.511390 0.291 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.480340 0.318 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.634077 0.198 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.634077 0.198 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.671174 0.173 1 1
Signaling by FGFR in disease R-HSA-1226099 0.451273 0.346 0 0
Generic Transcription Pathway R-HSA-212436 0.336916 0.472 1 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.392886 0.406 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.322226 0.492 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.668590 0.175 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.596397 0.224 0 0
Interleukin-2 family signaling R-HSA-451927 0.441241 0.355 0 0
G2/M Checkpoints R-HSA-69481 0.542960 0.265 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.304430 0.517 0 0
Specification of the neural plate border R-HSA-9834899 0.290274 0.537 0 0
Cellular Senescence R-HSA-2559583 0.575346 0.240 0 0
Activation of BH3-only proteins R-HSA-114452 0.118941 0.925 0 0
Signaling by ALK in cancer R-HSA-9700206 0.375123 0.426 0 0
Signaling by EGFR R-HSA-177929 0.587668 0.231 0 0
Membrane Trafficking R-HSA-199991 0.600795 0.221 0 0
Signaling by VEGF R-HSA-194138 0.520346 0.284 0 0
Signaling by MET R-HSA-6806834 0.299871 0.523 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 0.202824 0.693 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.148862 0.827 0 0
Transport of connexins along the secretory pathway R-HSA-190827 0.288251 0.540 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 0.288251 0.540 0 0
NrCAM interactions R-HSA-447038 0.188796 0.724 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.188796 0.724 0 0
Sensory perception of salty taste R-HSA-9730628 0.229948 0.638 0 0
mRNA Editing: A to I Conversion R-HSA-75064 0.364528 0.438 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.364528 0.438 0 0
C6 deamination of adenosine R-HSA-75102 0.364528 0.438 0 0
TGFBR3 regulates activin signaling R-HSA-9839406 0.364528 0.438 0 0
Regulation of KIT signaling R-HSA-1433559 0.150065 0.824 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 0.271599 0.566 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 0.271599 0.566 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.123378 0.909 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.193818 0.713 0 0
Differentiation of T cells R-HSA-9945266 0.193818 0.713 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.242738 0.615 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.432635 0.364 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.432635 0.364 0 0
Disorders of Developmental Biology R-HSA-9675151 0.217021 0.663 0 0
TBC/RABGAPs R-HSA-8854214 0.130560 0.884 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.303471 0.518 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 0.303471 0.518 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.098909 1.005 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.209505 0.679 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.366217 0.436 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.225889 0.646 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.322226 0.492 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.547742 0.261 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 0.454560 0.342 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.506854 0.295 0 0
NF-kB is activated and signals survival R-HSA-209560 0.506854 0.295 0 0
Synthesis of PS R-HSA-1483101 0.596221 0.225 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 0.573917 0.241 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 0.590310 0.229 0 0
Agmatine biosynthesis R-HSA-351143 0.639507 0.194 0 0
Budding and maturation of HIV virion R-HSA-162588 0.603613 0.219 0 0
mTORC1-mediated signalling R-HSA-166208 0.614716 0.211 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.615157 0.211 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.627588 0.202 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.660510 0.180 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.661570 0.179 0 0
Cysteine formation from homocysteine R-HSA-1614603 0.678154 0.169 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.101872 0.992 0 0
Signal Transduction R-HSA-162582 0.095589 1.020 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.398123 0.400 0 0
G1/S Transition R-HSA-69206 0.327795 0.484 1 0
MAPK family signaling cascades R-HSA-5683057 0.495846 0.305 0 0
Collagen degradation R-HSA-1442490 0.382286 0.418 0 0
MAP kinase activation R-HSA-450294 0.382286 0.418 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.334153 0.476 0 0
G2/M Transition R-HSA-69275 0.308708 0.510 1 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.300450 0.522 1 0
Interleukin-17 signaling R-HSA-448424 0.391465 0.407 0 0
Rab regulation of trafficking R-HSA-9007101 0.518915 0.285 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.325818 0.487 1 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.490566 0.309 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.511390 0.291 0 0
PTK6 Activates STAT3 R-HSA-8849474 0.547742 0.261 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.304281 0.517 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.644323 0.191 0 0
Activation of SMO R-HSA-5635838 0.661570 0.179 0 0
HIV Infection R-HSA-162906 0.525205 0.280 1 0
Downstream signal transduction R-HSA-186763 0.245615 0.610 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.394326 0.404 0 0
Neurofascin interactions R-HSA-447043 0.639507 0.194 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.184435 0.734 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.194780 0.710 0 0
DCC mediated attractive signaling R-HSA-418885 0.364770 0.438 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.352440 0.453 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.603613 0.219 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.288916 0.539 0 0
Signaling by PTK6 R-HSA-8848021 0.288916 0.539 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.256695 0.591 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.505612 0.296 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.272925 0.564 0 0
Pervasive developmental disorders R-HSA-9005895 0.272925 0.564 0 0
Disorders of Nervous System Development R-HSA-9697154 0.272925 0.564 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 0.334153 0.476 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 0.493446 0.307 0 0
Formation of intermediate mesoderm R-HSA-9761174 0.433273 0.363 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.401601 0.396 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.678154 0.169 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.391465 0.407 0 0
Pexophagy R-HSA-9664873 0.433273 0.363 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.681878 0.166 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 0.313169 0.504 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.472570 0.326 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.177110 0.752 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.366217 0.436 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.454560 0.342 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.408917 0.388 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.184435 0.734 0 0
Signaling by ALK R-HSA-201556 0.156291 0.806 0 0
Tie2 Signaling R-HSA-210993 0.265386 0.576 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.537544 0.270 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.175714 0.755 0 0
FOXO-mediated transcription R-HSA-9614085 0.368334 0.434 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.495654 0.305 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.594672 0.226 1 0
Signaling by TGFBR3 R-HSA-9839373 0.165056 0.782 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.386980 0.412 0 0
Oligomerization of connexins into connexons R-HSA-190704 0.288251 0.540 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.334153 0.476 0 0
Sensory perception of sour taste R-HSA-9729555 0.493446 0.307 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 0.433273 0.363 0 0
Synthesis of PI R-HSA-1483226 0.470832 0.327 0 0
Activation of AKT2 R-HSA-165158 0.547742 0.261 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 0.596221 0.225 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.564927 0.248 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.604865 0.218 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.604865 0.218 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 0.639507 0.194 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 0.639507 0.194 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.638120 0.195 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.644323 0.191 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.660510 0.180 0 0
Negative regulation of FLT3 R-HSA-9706369 0.661570 0.179 0 0
VLDL clearance R-HSA-8964046 0.678154 0.169 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.480340 0.318 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.615157 0.211 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.214525 0.669 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.209505 0.679 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.450288 0.347 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.376538 0.424 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.340240 0.468 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.283346 0.548 1 1
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.298594 0.525 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.681878 0.166 0 0
PI Metabolism R-HSA-1483255 0.304860 0.516 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.597048 0.224 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.612982 0.213 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.633394 0.198 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.130728 0.884 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.657572 0.182 1 1
Ca2+ pathway R-HSA-4086398 0.436349 0.360 0 0
Apoptosis R-HSA-109581 0.476587 0.322 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.518571 0.285 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.364770 0.438 0 0
Interleukin-37 signaling R-HSA-9008059 0.386803 0.413 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.452742 0.344 0 0
Myogenesis R-HSA-525793 0.490566 0.309 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.516615 0.287 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.492617 0.307 0 0
Kinesins R-HSA-983189 0.649973 0.187 0 0
Signaling by SCF-KIT R-HSA-1433557 0.358349 0.446 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.564927 0.248 0 0
tRNA processing R-HSA-72306 0.315566 0.501 0 0
UCH proteinases R-HSA-5689603 0.249728 0.603 0 0
Formation of the anterior neural plate R-HSA-9823739 0.364770 0.438 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.651092 0.186 0 0
Signaling by PDGF R-HSA-186797 0.398123 0.400 0 0
FLT3 Signaling R-HSA-9607240 0.460880 0.336 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 0.364528 0.438 0 0
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells R-HSA-210746 0.271599 0.566 0 0
Anchoring fibril formation R-HSA-2214320 0.242738 0.615 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.313169 0.504 0 0
The NLRP1 inflammasome R-HSA-844455 0.432635 0.364 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.394326 0.404 0 0
Dopamine receptors R-HSA-390651 0.493446 0.307 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 0.493446 0.307 0 0
Collagen chain trimerization R-HSA-8948216 0.235664 0.628 0 0
Fibronectin matrix formation R-HSA-1566977 0.425120 0.371 0 0
Relaxin receptors R-HSA-444821 0.596221 0.225 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.573917 0.241 0 0
NADPH regeneration R-HSA-389542 0.639507 0.194 0 0
Signaling by LTK in cancer R-HSA-9842640 0.639507 0.194 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 0.678154 0.169 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.678154 0.169 0 0
Netrin-1 signaling R-HSA-373752 0.537271 0.270 0 0
Sensory processing of sound R-HSA-9659379 0.524728 0.280 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.456204 0.341 0 0
Gene Silencing by RNA R-HSA-211000 0.375123 0.426 0 0
PKR-mediated signaling R-HSA-9833482 0.413610 0.383 0 0
tRNA modification in the mitochondrion R-HSA-6787450 0.687375 0.163 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.394326 0.404 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.511390 0.291 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.684443 0.165 1 1
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.188796 0.724 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.173005 0.762 0 0
Regulation of CDH11 function R-HSA-9762292 0.433273 0.363 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.454560 0.342 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 0.596221 0.225 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 0.596221 0.225 0 0
NCAM1 interactions R-HSA-419037 0.557398 0.254 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.634077 0.198 0 0
CHL1 interactions R-HSA-447041 0.678154 0.169 0 0
Physiological factors R-HSA-5578768 0.334153 0.476 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.425120 0.371 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.638120 0.195 0 0
Diseases of DNA repair R-HSA-9675135 0.573690 0.241 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.547742 0.261 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 0.596221 0.225 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 0.687375 0.163 0 0
Glycolysis R-HSA-70171 0.603475 0.219 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 0.547742 0.261 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.439048 0.357 0 0
Assembly Of The HIV Virion R-HSA-175474 0.590310 0.229 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.604865 0.218 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 0.639507 0.194 0 0
Signaling by Leptin R-HSA-2586552 0.433273 0.363 0 0
Regulation of beta-cell development R-HSA-186712 0.489164 0.311 0 0
Interleukin-7 signaling R-HSA-1266695 0.681878 0.166 0 0
Growth hormone receptor signaling R-HSA-982772 0.638120 0.195 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.688558 0.162 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.688558 0.162 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.689476 0.161 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.689476 0.161 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.689476 0.161 0 0
S Phase R-HSA-69242 0.694491 0.158 1 0
Host Interactions of HIV factors R-HSA-162909 0.696193 0.157 0 0
G1 Phase R-HSA-69236 0.700834 0.154 1 0
Cyclin D associated events in G1 R-HSA-69231 0.700834 0.154 1 1
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.702227 0.154 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.702227 0.154 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 0.702227 0.154 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.702227 0.154 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.705176 0.152 0 0
Cell junction organization R-HSA-446728 0.708647 0.150 0 0
Signaling by NOTCH4 R-HSA-9013694 0.709958 0.149 0 0
L1CAM interactions R-HSA-373760 0.710670 0.148 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.711540 0.148 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.711540 0.148 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 0.711540 0.148 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.711540 0.148 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.711540 0.148 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.711540 0.148 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.711540 0.148 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.711540 0.148 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 0.712660 0.147 0 0
Activation of RAS in B cells R-HSA-1169092 0.712660 0.147 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.712660 0.147 0 0
Co-stimulation by ICOS R-HSA-9927354 0.712660 0.147 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.712660 0.147 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.712660 0.147 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.712660 0.147 0 0
Nucleosome assembly R-HSA-774815 0.716274 0.145 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.716274 0.145 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.717108 0.144 0 0
GPVI-mediated activation cascade R-HSA-114604 0.717108 0.144 0 0
FLT3 signaling in disease R-HSA-9682385 0.717108 0.144 0 0
Programmed Cell Death R-HSA-5357801 0.718120 0.144 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.721568 0.142 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.721568 0.142 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.721568 0.142 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.721568 0.142 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.721568 0.142 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.721568 0.142 0 0
Maturation of hRSV A proteins R-HSA-9828806 0.721568 0.142 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.730075 0.137 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.731139 0.136 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.732144 0.135 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.733478 0.135 0 0
Metabolism of folate and pterines R-HSA-196757 0.733478 0.135 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.734119 0.134 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.734119 0.134 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.734119 0.134 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.734119 0.134 0 0
PKA activation in glucagon signalling R-HSA-164378 0.734119 0.134 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.734119 0.134 0 0
Mismatch Repair R-HSA-5358508 0.734119 0.134 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 0.734119 0.134 0 0
Nephron development R-HSA-9831926 0.734119 0.134 0 0
Interferon Signaling R-HSA-913531 0.734856 0.134 0 0
HIV elongation arrest and recovery R-HSA-167287 0.739915 0.131 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.739915 0.131 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 0.743468 0.129 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.743468 0.129 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 0.743468 0.129 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.743468 0.129 0 0
mRNA Editing R-HSA-75072 0.743468 0.129 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.743468 0.129 0 0
Regulation of signaling by NODAL R-HSA-1433617 0.743468 0.129 0 0
MAPK1 (ERK2) activation R-HSA-112411 0.743468 0.129 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.743468 0.129 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 0.743468 0.129 0 0
Lipophagy R-HSA-9613354 0.743468 0.129 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.743468 0.129 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 0.743468 0.129 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.743468 0.129 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.745432 0.128 0 0
ESR-mediated signaling R-HSA-8939211 0.745705 0.127 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.755174 0.122 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.755174 0.122 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 0.755174 0.122 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.755174 0.122 0 0
Diseases of hemostasis R-HSA-9671793 0.755174 0.122 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.756334 0.121 0 0
mRNA Capping R-HSA-72086 0.757288 0.121 1 1
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.757288 0.121 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.757288 0.121 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.759155 0.120 0 0
Cellular response to chemical stress R-HSA-9711123 0.763643 0.117 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.764058 0.117 1 1
mRNA Splicing - Major Pathway R-HSA-72163 0.767666 0.115 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.769183 0.114 0 0
HCMV Late Events R-HSA-9610379 0.769379 0.114 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.770975 0.113 0 0
DNA replication initiation R-HSA-68952 0.770975 0.113 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 0.770975 0.113 0 0
Interleukin-27 signaling R-HSA-9020956 0.770975 0.113 0 0
Arachidonate production from DAG R-HSA-426048 0.770975 0.113 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.770975 0.113 0 0
2-LTR circle formation R-HSA-164843 0.770975 0.113 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.770975 0.113 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.770975 0.113 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.770975 0.113 0 0
Regulation of the apoptosome activity R-HSA-9627069 0.770975 0.113 0 0
Formation of apoptosome R-HSA-111458 0.770975 0.113 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.773711 0.111 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.773711 0.111 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.773711 0.111 0 0
Signaling by WNT R-HSA-195721 0.774199 0.111 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.774772 0.111 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.774772 0.111 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.774772 0.111 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.774772 0.111 0 0
Negative regulation of MET activity R-HSA-6807004 0.774772 0.111 0 0
Nephrin family interactions R-HSA-373753 0.774772 0.111 0 0
mRNA Splicing R-HSA-72172 0.777632 0.109 0 0
Signaling by FGFR2 R-HSA-5654738 0.778104 0.109 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.778104 0.109 1 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.778288 0.109 1 1
HIV Transcription Elongation R-HSA-167169 0.778288 0.109 1 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.778288 0.109 1 1
Aggrephagy R-HSA-9646399 0.778288 0.109 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.778912 0.109 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.778912 0.109 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.781418 0.107 0 0
Signaling by FGFR R-HSA-190236 0.788019 0.103 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.789604 0.103 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.789604 0.103 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.792985 0.101 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 0.792985 0.101 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.792985 0.101 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.792985 0.101 0 0
Signalling to RAS R-HSA-167044 0.792985 0.101 0 0
Basigin interactions R-HSA-210991 0.792985 0.101 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.795533 0.099 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 0.795533 0.099 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 0.795533 0.099 0 0
Interleukin-2 signaling R-HSA-9020558 0.795533 0.099 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.795533 0.099 0 0
Ionotropic activity of kainate receptors R-HSA-451306 0.795533 0.099 0 0
Bicarbonate transporters R-HSA-425381 0.795533 0.099 0 0
Transport of RCbl within the body R-HSA-9758890 0.795533 0.099 0 0
LGI-ADAM interactions R-HSA-5682910 0.795533 0.099 0 0
PECAM1 interactions R-HSA-210990 0.795533 0.099 0 0
Suppression of apoptosis R-HSA-9635465 0.795533 0.099 0 0
Prostanoid ligand receptors R-HSA-391908 0.795533 0.099 0 0
HSF1-dependent transactivation R-HSA-3371571 0.796969 0.099 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.797264 0.098 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.803819 0.095 0 0
DNA strand elongation R-HSA-69190 0.803819 0.095 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.804700 0.094 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.805534 0.094 0 0
Glucose metabolism R-HSA-70326 0.805956 0.094 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.808485 0.092 1 1
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.809882 0.092 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.809882 0.092 0 0
Glutathione synthesis and recycling R-HSA-174403 0.809882 0.092 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.809882 0.092 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 0.817460 0.088 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.817460 0.088 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.817460 0.088 0 0
Plasmalogen biosynthesis R-HSA-75896 0.817460 0.088 0 0
ERKs are inactivated R-HSA-202670 0.817460 0.088 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 0.817460 0.088 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 0.817460 0.088 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 0.817460 0.088 0 0
DS-GAG biosynthesis R-HSA-2022923 0.817460 0.088 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.817565 0.087 0 0
Integrin signaling R-HSA-354192 0.817565 0.087 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.817565 0.087 0 0
Cell-Cell communication R-HSA-1500931 0.818625 0.087 0 0
Signaling by ERBB4 R-HSA-1236394 0.819337 0.087 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.819475 0.086 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.825538 0.083 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.825538 0.083 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.825538 0.083 0 0
Ethanol oxidation R-HSA-71384 0.825538 0.083 0 0
Signaling by KIT in disease R-HSA-9669938 0.825538 0.083 0 0
Signaling by FGFR4 R-HSA-5654743 0.828495 0.082 0 0
Striated Muscle Contraction R-HSA-390522 0.830482 0.081 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.830482 0.081 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.830482 0.081 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.831349 0.080 0 0
Nervous system development R-HSA-9675108 0.832935 0.079 0 0
Cellular response to hypoxia R-HSA-1234174 0.833150 0.079 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.835179 0.078 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.836126 0.078 0 0
IRAK1 recruits IKK complex R-HSA-937039 0.837036 0.077 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 0.837036 0.077 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.837036 0.077 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 0.837036 0.077 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.837036 0.077 0 0
Interleukin-35 Signalling R-HSA-8984722 0.837036 0.077 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 0.837036 0.077 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.837036 0.077 0 0
OAS antiviral response R-HSA-8983711 0.837036 0.077 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.839170 0.076 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.839459 0.076 0 0
DAP12 interactions R-HSA-2172127 0.839459 0.076 0 0
HCMV Early Events R-HSA-9609690 0.839803 0.076 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.839927 0.076 0 0
Carnitine shuttle R-HSA-200425 0.840024 0.076 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 0.840024 0.076 0 0
Syndecan interactions R-HSA-3000170 0.840024 0.076 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.840024 0.076 0 0
Formation of the ureteric bud R-HSA-9830674 0.840024 0.076 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.842607 0.074 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.842607 0.074 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.849417 0.071 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.849417 0.071 1 1
Post NMDA receptor activation events R-HSA-438064 0.849668 0.071 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.849829 0.071 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.851625 0.070 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.853410 0.069 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.853410 0.069 0 0
Neurodegenerative Diseases R-HSA-8863678 0.853410 0.069 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.853410 0.069 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.853958 0.069 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.853958 0.069 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.853972 0.069 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.853972 0.069 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.854514 0.068 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.854514 0.068 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.854514 0.068 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 0.854514 0.068 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.854514 0.068 0 0
Processing of SMDT1 R-HSA-8949664 0.854514 0.068 0 0
Maturation of nucleoprotein R-HSA-9683610 0.854514 0.068 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 0.854514 0.068 0 0
Selective autophagy R-HSA-9663891 0.857155 0.067 0 0
Co-inhibition by PD-1 R-HSA-389948 0.860507 0.065 0 0
Calmodulin induced events R-HSA-111933 0.864613 0.063 0 0
CaM pathway R-HSA-111997 0.864613 0.063 0 0
Triglyceride catabolism R-HSA-163560 0.864613 0.063 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.865766 0.063 0 0
G protein gated Potassium channels R-HSA-1296059 0.865766 0.063 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 0.865766 0.063 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 0.865766 0.063 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.865766 0.063 0 0
Tight junction interactions R-HSA-420029 0.865766 0.063 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.868871 0.061 0 0
Recycling pathway of L1 R-HSA-437239 0.868871 0.061 0 0
Removal of the Flap Intermediate R-HSA-69166 0.870119 0.060 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 0.870119 0.060 0 0
FGFR3c ligand binding and activation R-HSA-190372 0.870119 0.060 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.870119 0.060 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 0.870119 0.060 0 0
HDL assembly R-HSA-8963896 0.870119 0.060 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 0.870119 0.060 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 0.870119 0.060 0 0
COPII-mediated vesicle transport R-HSA-204005 0.874847 0.058 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.877159 0.057 0 0
MET activates PTK2 signaling R-HSA-8874081 0.877159 0.057 0 0
TRP channels R-HSA-3295583 0.877159 0.057 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.877159 0.057 0 0
Co-stimulation by CD28 R-HSA-389356 0.877587 0.057 0 0
Hedgehog 'on' state R-HSA-5632684 0.882046 0.055 0 0
Glutathione conjugation R-HSA-156590 0.882813 0.054 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.883057 0.054 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.883057 0.054 0 0
Biofilm formation R-HSA-9931953 0.883864 0.054 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.883864 0.054 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.883864 0.054 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.884050 0.054 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.884050 0.054 0 0
Protein lipoylation R-HSA-9857492 0.884050 0.054 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.884050 0.054 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 0.884050 0.054 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.884050 0.054 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 0.884050 0.054 0 0
p38MAPK events R-HSA-171007 0.884050 0.054 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.884050 0.054 0 0
Protein methylation R-HSA-8876725 0.884050 0.054 0 0
Autophagy R-HSA-9612973 0.885127 0.053 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.886050 0.053 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.886050 0.053 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.887654 0.052 0 0
Cristae formation R-HSA-8949613 0.887654 0.052 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.887654 0.052 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.888893 0.051 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.888893 0.051 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.890915 0.050 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.891896 0.050 0 0
Axon guidance R-HSA-422475 0.892052 0.050 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.892542 0.049 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.892542 0.049 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.893522 0.049 0 0
Chromosome Maintenance R-HSA-73886 0.896379 0.048 0 0
Phosphorylation of the APC/C R-HSA-176412 0.896488 0.047 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 0.896488 0.047 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.896488 0.047 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.896488 0.047 0 0
Phase 4 - resting membrane potential R-HSA-5576886 0.896488 0.047 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.896488 0.047 0 0
Killing mechanisms R-HSA-9664420 0.896488 0.047 0 0
Fructose catabolism R-HSA-70350 0.896488 0.047 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.896488 0.047 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.896488 0.047 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.896488 0.047 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.897311 0.047 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.897311 0.047 0 0
Reproduction R-HSA-1474165 0.898925 0.046 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.899288 0.046 0 0
Attenuation phase R-HSA-3371568 0.900634 0.045 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.900634 0.045 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.900785 0.045 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.901247 0.045 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.901247 0.045 0 0
Collagen formation R-HSA-1474290 0.901490 0.045 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.905923 0.043 0 0
DARPP-32 events R-HSA-180024 0.906190 0.043 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.906190 0.043 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.906190 0.043 0 0
Glucagon-type ligand receptors R-HSA-420092 0.906190 0.043 0 0
Metabolism of RNA R-HSA-8953854 0.906194 0.043 1 0
HCMV Infection R-HSA-9609646 0.906289 0.043 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.906622 0.043 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.907438 0.042 0 0
RSV-host interactions R-HSA-9833110 0.907562 0.042 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.907592 0.042 0 0
Glycine degradation R-HSA-6783984 0.907592 0.042 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 0.907592 0.042 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.907592 0.042 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.907592 0.042 0 0
Synthesis of PG R-HSA-1483148 0.907592 0.042 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 0.907592 0.042 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.907606 0.042 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.907606 0.042 1 1
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.907606 0.042 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.907966 0.042 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.908171 0.042 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.913362 0.039 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.914008 0.039 1 1
Meiotic synapsis R-HSA-1221632 0.914008 0.039 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.914008 0.039 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.914008 0.039 0 0
Smooth Muscle Contraction R-HSA-445355 0.914008 0.039 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.914347 0.039 0 0
Cellular responses to stress R-HSA-2262752 0.914770 0.039 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.917506 0.037 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.917506 0.037 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.917506 0.037 0 0
Catecholamine biosynthesis R-HSA-209905 0.917506 0.037 0 0
Sulfide oxidation to sulfate R-HSA-1614517 0.917506 0.037 0 0
Glycogen storage diseases R-HSA-3229121 0.917506 0.037 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 0.917506 0.037 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.921710 0.035 0 0
Ca-dependent events R-HSA-111996 0.921710 0.035 0 0
EGFR downregulation R-HSA-182971 0.921833 0.035 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.923549 0.035 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.924584 0.034 0 0
Kidney development R-HSA-9830369 0.926099 0.033 0 0
GAB1 signalosome R-HSA-180292 0.926357 0.033 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.926357 0.033 0 0
Apoptotic factor-mediated response R-HSA-111471 0.926357 0.033 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.926357 0.033 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 0.926357 0.033 0 0
Platelet sensitization by LDL R-HSA-432142 0.926357 0.033 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 0.926357 0.033 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.927960 0.032 0 0
Inwardly rectifying K+ channels R-HSA-1296065 0.928700 0.032 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.928700 0.032 0 0
Signaling by FGFR1 R-HSA-5654736 0.930901 0.031 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.931133 0.031 0 0
Adherens junctions interactions R-HSA-418990 0.932072 0.031 0 0
Amine ligand-binding receptors R-HSA-375280 0.933399 0.030 0 0
RMTs methylate histone arginines R-HSA-3214858 0.933399 0.030 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.934258 0.030 0 0
Maturation of nucleoprotein R-HSA-9694631 0.934258 0.030 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 0.934258 0.030 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.934994 0.029 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.934994 0.029 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.935409 0.029 0 0
Synthesis of PA R-HSA-1483166 0.935827 0.029 0 0
Influenza Infection R-HSA-168255 0.936242 0.029 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.936594 0.028 0 0
Somitogenesis R-HSA-9824272 0.938620 0.028 0 0
DAG and IP3 signaling R-HSA-1489509 0.938620 0.028 0 0
Dual incision in TC-NER R-HSA-6782135 0.940432 0.027 1 1
Signaling by Nuclear Receptors R-HSA-9006931 0.940497 0.027 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.940758 0.027 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.940758 0.027 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 0.941312 0.026 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.941312 0.026 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 0.941312 0.026 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 0.941312 0.026 0 0
Glycogen synthesis R-HSA-3322077 0.941312 0.026 0 0
Pregnenolone biosynthesis R-HSA-196108 0.941312 0.026 0 0
Protein hydroxylation R-HSA-9629569 0.941312 0.026 0 0
Signal transduction by L1 R-HSA-445144 0.941312 0.026 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 0.941312 0.026 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.943460 0.025 1 1
Macroautophagy R-HSA-1632852 0.943642 0.025 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.943861 0.025 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.943861 0.025 0 0
ECM proteoglycans R-HSA-3000178 0.943861 0.025 0 0
Extension of Telomeres R-HSA-180786 0.944734 0.025 0 0
Peroxisomal protein import R-HSA-9033241 0.944734 0.025 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.946035 0.024 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.946035 0.024 0 0
Mitophagy R-HSA-5205647 0.946035 0.024 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.946035 0.024 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.946035 0.024 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.946197 0.024 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.946632 0.024 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.946909 0.024 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.947498 0.023 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.947652 0.023 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.947943 0.023 0 0
Meiosis R-HSA-1500620 0.951236 0.022 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.951236 0.022 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.952356 0.021 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.952497 0.021 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.953232 0.021 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.953232 0.021 0 0
HSF1 activation R-HSA-3371511 0.955274 0.020 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.955274 0.020 0 0
Gap junction trafficking and regulation R-HSA-157858 0.955933 0.020 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.955933 0.020 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.955933 0.020 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.955990 0.020 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.957674 0.019 1 1
Potassium Channels R-HSA-1296071 0.957790 0.019 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 0.958251 0.019 0 0
Fructose metabolism R-HSA-5652084 0.958251 0.019 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 0.958251 0.019 0 0
LDL clearance R-HSA-8964038 0.958251 0.019 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 0.958251 0.019 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.958862 0.018 0 0
Cell-cell junction organization R-HSA-421270 0.959091 0.018 0 0
Semaphorin interactions R-HSA-373755 0.959245 0.018 0 0
Degradation of AXIN R-HSA-4641257 0.959305 0.018 0 0
Voltage gated Potassium channels R-HSA-1296072 0.959305 0.018 0 0
Cleavage of the damaged purine R-HSA-110331 0.959305 0.018 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 0.959305 0.018 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.961206 0.017 0 0
Stimuli-sensing channels R-HSA-2672351 0.961206 0.017 0 0
Mitochondrial mRNA modification R-HSA-9937008 0.962732 0.016 0 0
Organic anion transport by SLCO transporters R-HSA-879518 0.962732 0.016 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 0.962732 0.016 0 0
Regulation of insulin secretion R-HSA-422356 0.962881 0.016 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.962987 0.016 0 0
tRNA processing in the mitochondrion R-HSA-6785470 0.962987 0.016 0 0
Depurination R-HSA-73927 0.962987 0.016 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 0.962987 0.016 0 0
Signaling by Hedgehog R-HSA-5358351 0.963138 0.016 0 0
Orc1 removal from chromatin R-HSA-68949 0.965792 0.015 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.965792 0.015 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.965792 0.015 0 0
Cholesterol biosynthesis R-HSA-191273 0.965910 0.015 0 0
Stabilization of p53 R-HSA-69541 0.966348 0.015 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.966732 0.015 0 0
Complex III assembly R-HSA-9865881 0.966732 0.015 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.966732 0.015 0 0
Plasma lipoprotein assembly R-HSA-8963898 0.966732 0.015 0 0
Neurotransmitter release cycle R-HSA-112310 0.967504 0.014 0 0
Base Excision Repair R-HSA-73884 0.967504 0.014 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.969414 0.013 0 0
Generation of second messenger molecules R-HSA-202433 0.969414 0.013 0 0
rRNA processing in the mitochondrion R-HSA-8868766 0.969414 0.013 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.970303 0.013 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.970303 0.013 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 0.970303 0.013 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 0.970303 0.013 0 0
Hyaluronan degradation R-HSA-2160916 0.970303 0.013 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.970303 0.013 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.970303 0.013 0 0
Formation of the nephric duct R-HSA-9830364 0.970303 0.013 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.970551 0.013 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.971165 0.013 0 0
Cellular responses to stimuli R-HSA-8953897 0.971253 0.013 0 0
MHC class II antigen presentation R-HSA-2132295 0.972102 0.012 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.972209 0.012 0 0
Maturation of spike protein R-HSA-9694548 0.972209 0.012 0 0
Regulated Necrosis R-HSA-5218859 0.972422 0.012 0 0
Suppression of phagosomal maturation R-HSA-9637687 0.973491 0.012 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.973491 0.012 0 0
Metalloprotease DUBs R-HSA-5689901 0.973491 0.012 0 0
Urea cycle R-HSA-70635 0.973491 0.012 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 0.973491 0.012 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.973491 0.012 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.973542 0.012 0 0
G alpha (z) signalling events R-HSA-418597 0.973542 0.012 0 0
EPH-Ephrin signaling R-HSA-2682334 0.973615 0.012 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 0.974757 0.011 0 0
Heme biosynthesis R-HSA-189451 0.974757 0.011 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.974757 0.011 0 0
SLC transporter disorders R-HSA-5619102 0.975666 0.011 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 0.976337 0.010 0 0
Packaging Of Telomere Ends R-HSA-171306 0.976337 0.010 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 0.976337 0.010 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.976337 0.010 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 0.976337 0.010 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 0.976337 0.010 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.976477 0.010 0 0
GABA B receptor activation R-HSA-977444 0.977079 0.010 0 0
Activation of GABAB receptors R-HSA-991365 0.977079 0.010 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.977079 0.010 0 0
Depyrimidination R-HSA-73928 0.977079 0.010 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.977079 0.010 0 0
Vesicle-mediated transport R-HSA-5653656 0.977487 0.010 0 0
Dectin-2 family R-HSA-5621480 0.977750 0.010 0 0
Telomere Extension By Telomerase R-HSA-171319 0.978877 0.009 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.978877 0.009 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.978877 0.009 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.978877 0.009 0 0
Pyroptosis R-HSA-5620971 0.978877 0.009 0 0
Inflammasomes R-HSA-622312 0.978877 0.009 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 0.979193 0.009 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.979193 0.009 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.979567 0.009 0 0
Interferon gamma signaling R-HSA-877300 0.979749 0.009 0 0
Synthesis of DNA R-HSA-69239 0.980912 0.008 0 0
Gap junction trafficking R-HSA-190828 0.981118 0.008 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.981118 0.008 0 0
Surfactant metabolism R-HSA-5683826 0.981118 0.008 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 0.981145 0.008 0 0
Platelet calcium homeostasis R-HSA-418360 0.981145 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 0.981145 0.008 0 0
Triglyceride metabolism R-HSA-8979227 0.981315 0.008 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.981522 0.008 0 0
Telomere Maintenance R-HSA-157579 0.982779 0.008 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.982869 0.008 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.982869 0.008 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.982886 0.007 0 0
Neurotransmitter clearance R-HSA-112311 0.983169 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.983169 0.007 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.983200 0.007 0 0
Leishmania phagocytosis R-HSA-9664417 0.983200 0.007 0 0
Parasite infection R-HSA-9664407 0.983200 0.007 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.983360 0.007 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.983469 0.007 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.983469 0.007 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.984203 0.007 0 0
Protein ubiquitination R-HSA-8852135 0.984297 0.007 0 0
PLC beta mediated events R-HSA-112043 0.984330 0.007 0 0
Phospholipid metabolism R-HSA-1483257 0.984942 0.007 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.984977 0.007 0 0
Cargo concentration in the ER R-HSA-5694530 0.984977 0.007 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.985911 0.006 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 0.985911 0.006 0 0
Hedgehog 'off' state R-HSA-5610787 0.986152 0.006 0 0
Complex I biogenesis R-HSA-6799198 0.986876 0.006 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.986876 0.006 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.986876 0.006 0 0
GPER1 signaling R-HSA-9634597 0.987227 0.006 0 0
Integrin cell surface interactions R-HSA-216083 0.987729 0.005 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.987995 0.005 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.988030 0.005 0 0
G-protein beta:gamma signalling R-HSA-397795 0.988030 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 0.988030 0.005 0 0
Toll-like Receptor Cascades R-HSA-168898 0.988578 0.005 0 0
Cellular response to starvation R-HSA-9711097 0.989196 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.989315 0.005 0 0
Heme degradation R-HSA-189483 0.989315 0.005 0 0
Azathioprine ADME R-HSA-9748787 0.989511 0.005 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.989692 0.004 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.989692 0.004 0 0
Integration of energy metabolism R-HSA-163685 0.989895 0.004 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.989989 0.004 0 0
eNOS activation R-HSA-203615 0.990463 0.004 0 0
Dual Incision in GG-NER R-HSA-5696400 0.990463 0.004 0 0
Gap junction assembly R-HSA-190861 0.990463 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 0.990463 0.004 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.990463 0.004 0 0
RA biosynthesis pathway R-HSA-5365859 0.990463 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 0.990463 0.004 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.990463 0.004 0 0
Meiotic recombination R-HSA-912446 0.990498 0.004 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.990498 0.004 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.990624 0.004 0 0
G-protein mediated events R-HSA-112040 0.990827 0.004 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.991394 0.004 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.991394 0.004 0 0
Developmental Cell Lineages R-HSA-9734767 0.991410 0.004 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.991487 0.004 0 0
PERK regulates gene expression R-HSA-381042 0.991487 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.991487 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.991487 0.004 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.991487 0.004 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 0.991487 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 0.991487 0.004 0 0
O-linked glycosylation of mucins R-HSA-913709 0.991619 0.004 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.991619 0.004 0 0
Platelet homeostasis R-HSA-418346 0.991767 0.004 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.992117 0.003 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.992207 0.003 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.992402 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 0.992402 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.992402 0.003 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.992571 0.003 1 1
Interleukin-1 family signaling R-HSA-446652 0.992616 0.003 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.992945 0.003 0 0
Translation initiation complex formation R-HSA-72649 0.992945 0.003 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.993010 0.003 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.993218 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 0.993218 0.003 0 0
Metabolism of porphyrins R-HSA-189445 0.993618 0.003 0 0
Elastic fibre formation R-HSA-1566948 0.993947 0.003 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.993951 0.003 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.994222 0.003 0 0
Ion homeostasis R-HSA-5578775 0.994222 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 0.994222 0.003 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.994222 0.003 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.994242 0.003 0 0
Signaling by ROBO receptors R-HSA-376176 0.994299 0.002 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.994335 0.002 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.994575 0.002 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.994597 0.002 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.994685 0.002 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.994788 0.002 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.994788 0.002 0 0
Diseases of programmed cell death R-HSA-9645723 0.995148 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.995152 0.002 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.995177 0.002 1 1
Glycogen metabolism R-HSA-8982491 0.995177 0.002 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.995271 0.002 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.995271 0.002 0 0
Interleukin-1 signaling R-HSA-9020702 0.995441 0.002 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.995441 0.002 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.995696 0.002 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.995696 0.002 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.995696 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 0.995696 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.995723 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 0.996132 0.002 0 0
GABA receptor activation R-HSA-977443 0.996132 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.996132 0.002 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.996158 0.002 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.996158 0.002 0 0
Intra-Golgi traffic R-HSA-6811438 0.996158 0.002 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.996158 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 0.996158 0.002 0 0
Neddylation R-HSA-8951664 0.996287 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 0.996325 0.002 0 0
Platelet degranulation R-HSA-114608 0.996341 0.002 0 0
Opioid Signalling R-HSA-111885 0.996433 0.002 0 0
Aquaporin-mediated transport R-HSA-445717 0.996503 0.002 0 0
Endogenous sterols R-HSA-211976 0.996503 0.002 0 0
IRE1alpha activates chaperones R-HSA-381070 0.996566 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.996571 0.001 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.996759 0.001 0 0
Mitochondrial protein import R-HSA-1268020 0.996839 0.001 0 0
Defective pyroptosis R-HSA-9710421 0.996939 0.001 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.996939 0.001 0 0
DNA Replication R-HSA-69306 0.997044 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 0.997268 0.001 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.997413 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.997562 0.001 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.997562 0.001 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.997562 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 0.997562 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 0.997562 0.001 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.997668 0.001 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.997824 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.997824 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.997824 0.001 0 0
TCR signaling R-HSA-202403 0.998005 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 0.998058 0.001 0 0
Synthesis of PC R-HSA-1483191 0.998058 0.001 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.998086 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 0.998097 0.001 0 0
Nicotinate metabolism R-HSA-196807 0.998097 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.998097 0.001 0 0
Intraflagellar transport R-HSA-5620924 0.998267 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.998314 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.998418 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 0.998453 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.998453 0.001 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.998555 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.998561 0.001 0 0
Muscle contraction R-HSA-397014 0.998564 0.001 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.998564 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 0.998577 0.001 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.998619 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 0.998619 0.001 0 0
Interleukin-12 family signaling R-HSA-447115 0.998691 0.001 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.998691 0.001 0 0
Metabolism of cofactors R-HSA-8978934 0.998735 0.001 0 0
Complex IV assembly R-HSA-9864848 0.998768 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 0.998768 0.001 0 0
The phototransduction cascade R-HSA-2514856 0.998768 0.001 0 0
Neuronal System R-HSA-112316 0.998816 0.001 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.998872 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.998897 0.000 0 0
Downstream TCR signaling R-HSA-202424 0.999016 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.999016 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 0.999019 0.000 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.999046 0.000 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.999124 0.000 0 0
Iron uptake and transport R-HSA-917937 0.999161 0.000 0 0
Cardiac conduction R-HSA-5576891 0.999170 0.000 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.999188 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 0.999218 0.000 0 0
Interleukin-12 signaling R-HSA-9020591 0.999244 0.000 0 0
Protein folding R-HSA-391251 0.999262 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.999262 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.999263 0.000 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.999367 0.000 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.999367 0.000 0 0
ABC transporter disorders R-HSA-5619084 0.999385 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.999385 0.000 0 0
PCP/CE pathway R-HSA-4086400 0.999385 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 0.999391 0.000 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.999447 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.999498 0.000 0 0
Potential therapeutics for SARS R-HSA-9679191 0.999519 0.000 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.999544 0.000 0 0
Amyloid fiber formation R-HSA-977225 0.999549 0.000 0 0
Metabolism of polyamines R-HSA-351202 0.999557 0.000 0 0
tRNA Aminoacylation R-HSA-379724 0.999557 0.000 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.999593 0.000 0 0
Protein localization R-HSA-9609507 0.999622 0.000 0 0
Extracellular matrix organization R-HSA-1474244 0.999631 0.000 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.999648 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 0.999670 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 0.999712 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 0.999719 0.000 0 0
Ion transport by P-type ATPases R-HSA-936837 0.999719 0.000 0 0
Xenobiotics R-HSA-211981 0.999719 0.000 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.999722 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999729 0.000 0 0
G alpha (s) signalling events R-HSA-418555 0.999743 0.000 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.999747 0.000 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.999747 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 0.999758 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 0.999801 0.000 0 0
Peptide chain elongation R-HSA-156902 0.999804 0.000 0 0
Ion channel transport R-HSA-983712 0.999812 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999829 0.000 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.999857 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.999859 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 0.999874 0.000 0 0
Signaling by Interleukins R-HSA-449147 0.999877 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 0.999880 0.000 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.999881 0.000 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.999884 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.999884 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 0.999884 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.999887 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.999895 0.000 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.999897 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 0.999899 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 0.999920 0.000 0 0
SARS-CoV Infections R-HSA-9679506 0.999920 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 0.999924 0.000 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.999924 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.999931 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 0.999931 0.000 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.999935 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.999938 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 0.999944 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 0.999948 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 0.999949 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.999950 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 0.999960 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.999960 0.000 0 0
Viral mRNA Translation R-HSA-192823 0.999967 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.999968 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 0.999971 0.000 0 0
Leishmania infection R-HSA-9658195 0.999971 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 0.999976 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.999981 0.000 0 0
Pyruvate metabolism R-HSA-70268 0.999982 0.000 0 0
rRNA processing R-HSA-72312 0.999982 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.999983 0.000 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.999984 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 0.999984 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.999986 0.000 0 0
Sensory perception of taste R-HSA-9717189 0.999991 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.999992 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.999993 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 0.999993 0.000 0 0
Diseases of glycosylation R-HSA-3781865 0.999994 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999995 0.000 0 0
Adaptive Immune System R-HSA-1280218 0.999996 0.000 0 0
O-linked glycosylation R-HSA-5173105 0.999996 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.999996 0.000 0 0
Mitochondrial translation R-HSA-5368287 0.999996 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.999997 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999997 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.999998 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999998 0.000 0 0
G alpha (q) signalling events R-HSA-416476 0.999999 0.000 0 0
Hemostasis R-HSA-109582 0.999999 0.000 0 0
Antimicrobial peptides R-HSA-6803157 0.999999 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 1.000000 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 1.000000 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 1.000000 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000 0.000 0 0
Viral Infection Pathways R-HSA-9824446 1.000000 0.000 1 0
Keratinization R-HSA-6805567 1.000000 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
Drug ADME R-HSA-9748784 1.000000 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000 0.000 0 0
Neutrophil degranulation R-HSA-6798695 1.000000 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Translation R-HSA-72766 1.000000 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Immune System R-HSA-168256 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Innate Immune System R-HSA-168249 1.000000 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000 -0.000 0 0
Disease R-HSA-1643685 1.000000 -0.000 1 0
Metabolism of lipids R-HSA-556833 1.000000 -0.000 0 0
Infectious disease R-HSA-5663205 1.000000 -0.000 1 0
Olfactory Signaling Pathway R-HSA-381753 1.000000 -0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.381089e-10 9.860 1 0
Cell Cycle, Mitotic R-HSA-69278 1.547420e-09 8.810 1 0
Nuclear Envelope Breakdown R-HSA-2980766 3.729275e-08 7.428 0 0
Apoptotic execution phase R-HSA-75153 4.487501e-08 7.348 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.773166e-07 6.557 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.826454e-07 6.417 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.228073e-07 6.282 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.352037e-07 6.078 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.493739e-07 6.023 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.264114e-06 5.898 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.829039e-06 5.738 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.047260e-06 5.689 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.835892e-06 5.547 0 0
Apoptosis R-HSA-109581 3.209076e-06 5.494 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.659906e-06 5.437 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.391812e-06 5.357 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.864855e-06 5.232 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.864855e-06 5.232 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.891824e-06 5.103 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.017089e-05 4.993 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.036760e-05 4.984 1 0
Mitotic Prophase R-HSA-68875 1.331254e-05 4.876 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.322086e-05 4.879 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.624519e-05 4.789 0 0
Nuclear import of Rev protein R-HSA-180746 1.704683e-05 4.768 0 0
Activation of BH3-only proteins R-HSA-114452 2.202640e-05 4.657 0 0
Cellular Senescence R-HSA-2559583 2.362545e-05 4.627 0 0
MTOR signalling R-HSA-165159 3.159023e-05 4.500 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.689921e-05 4.433 0 0
Chromatin organization R-HSA-4839726 3.872293e-05 4.412 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.377632e-05 4.359 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.966277e-05 4.304 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.966277e-05 4.304 0 0
Programmed Cell Death R-HSA-5357801 4.850451e-05 4.314 0 0
Gene expression (Transcription) R-HSA-74160 5.484151e-05 4.261 1 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.400238e-05 4.268 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.449631e-05 4.264 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.658811e-05 4.247 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.742789e-05 4.171 0 0
Membrane Trafficking R-HSA-199991 7.168404e-05 4.145 0 0
HIV Life Cycle R-HSA-162587 7.251975e-05 4.140 1 0
Cell Cycle Checkpoints R-HSA-69620 7.737480e-05 4.111 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.294099e-05 4.081 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.769870e-05 4.010 0 0
Cellular response to heat stress R-HSA-3371556 1.056771e-04 3.976 0 0
Signal Transduction R-HSA-162582 1.037922e-04 3.984 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.080954e-04 3.966 1 1
Chromatin modifying enzymes R-HSA-3247509 1.111530e-04 3.954 0 0
M Phase R-HSA-68886 1.120290e-04 3.951 0 0
G0 and Early G1 R-HSA-1538133 1.623977e-04 3.789 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.156534e-04 3.666 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.123724e-04 3.673 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.220321e-04 3.654 1 0
Late Phase of HIV Life Cycle R-HSA-162599 2.245278e-04 3.649 1 0
Mitotic Anaphase R-HSA-68882 2.515582e-04 3.599 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.572995e-04 3.590 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.644408e-04 3.578 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.710866e-04 3.567 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.139946e-04 3.503 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.044397e-04 3.516 0 0
Signaling by ALK in cancer R-HSA-9700206 3.044397e-04 3.516 0 0
tRNA processing in the nucleus R-HSA-6784531 3.068961e-04 3.513 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.242850e-04 3.489 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.244149e-04 3.489 1 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.033648e-04 3.394 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.099345e-04 3.387 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.117188e-04 3.385 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.360454e-04 3.360 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.712192e-04 3.327 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.728426e-04 3.325 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.764790e-04 3.322 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.380924e-04 3.269 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.175163e-04 3.286 1 0
Cell-extracellular matrix interactions R-HSA-446353 6.228062e-04 3.206 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.228062e-04 3.206 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.228062e-04 3.206 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.228062e-04 3.206 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.987309e-04 3.156 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.033086e-04 3.153 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.494075e-04 3.125 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.858937e-04 3.105 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.374998e-04 3.077 0 0
Cellular responses to stress R-HSA-2262752 8.588803e-04 3.066 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.116235e-04 3.040 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.413523e-04 3.026 0 0
Recycling pathway of L1 R-HSA-437239 1.013991e-03 2.994 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.060762e-03 2.974 0 0
HIV Infection R-HSA-162906 1.077304e-03 2.968 1 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.124684e-03 2.949 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.154790e-03 2.937 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.166389e-03 2.933 0 0
G2/M Checkpoints R-HSA-69481 1.196247e-03 2.922 0 0
mTORC1-mediated signalling R-HSA-166208 1.331541e-03 2.876 0 0
Signaling by LTK R-HSA-9842663 1.376261e-03 2.861 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.379554e-03 2.860 0 0
Signaling by Hippo R-HSA-2028269 1.439562e-03 2.842 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.454588e-03 2.837 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.478604e-03 2.830 1 1
Formation of annular gap junctions R-HSA-196025 1.498491e-03 2.824 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.498491e-03 2.824 0 0
Metabolism of non-coding RNA R-HSA-194441 1.797303e-03 2.745 0 0
snRNP Assembly R-HSA-191859 1.797303e-03 2.745 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.845725e-03 2.734 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.929879e-03 2.714 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.074518e-03 2.683 1 1
G1 Phase R-HSA-69236 2.046076e-03 2.689 1 0
Cyclin D associated events in G1 R-HSA-69231 2.046076e-03 2.689 1 1
Mitotic G2-G2/M phases R-HSA-453274 2.076994e-03 2.683 1 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.036642e-03 2.691 0 0
Neurodegenerative Diseases R-HSA-8863678 2.036642e-03 2.691 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.117960e-03 2.674 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.151214e-03 2.667 0 0
Gap junction degradation R-HSA-190873 2.180451e-03 2.661 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.180451e-03 2.661 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.369186e-03 2.625 1 1
XBP1(S) activates chaperone genes R-HSA-381038 2.376452e-03 2.624 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.484910e-03 2.605 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.484910e-03 2.605 0 0
Signal attenuation R-HSA-74749 3.064495e-03 2.514 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.919847e-03 2.535 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.068952e-03 2.513 0 0
Mitotic Prometaphase R-HSA-68877 2.880053e-03 2.541 0 0
Metabolism of RNA R-HSA-8953854 2.887082e-03 2.540 1 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.880666e-03 2.541 0 0
RNA Polymerase II Transcription R-HSA-73857 3.152886e-03 2.501 1 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.166292e-03 2.499 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.209793e-03 2.494 0 0
Signaling by EGFR R-HSA-177929 3.463621e-03 2.460 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.463621e-03 2.460 0 0
HCMV Early Events R-HSA-9609690 3.478460e-03 2.459 0 0
S Phase R-HSA-69242 3.725928e-03 2.429 1 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.907921e-03 2.408 0 0
MAP2K and MAPK activation R-HSA-5674135 4.099834e-03 2.387 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.099834e-03 2.387 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.276131e-03 2.369 1 0
Mitotic Spindle Checkpoint R-HSA-69618 4.547223e-03 2.342 0 0
Cell-Cell communication R-HSA-1500931 4.629694e-03 2.334 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.417524e-03 2.355 0 0
IRE1alpha activates chaperones R-HSA-381070 4.246172e-03 2.372 0 0
Oncogene Induced Senescence R-HSA-2559585 4.633471e-03 2.334 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.171831e-03 2.286 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.171831e-03 2.286 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.177705e-03 2.286 0 0
Cellular responses to stimuli R-HSA-8953897 5.606519e-03 2.251 0 0
Cell junction organization R-HSA-446728 5.921974e-03 2.228 0 0
mRNA Splicing R-HSA-72172 5.939520e-03 2.226 0 0
Inositol phosphate metabolism R-HSA-1483249 6.086771e-03 2.216 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.199781e-03 2.208 0 0
MET interacts with TNS proteins R-HSA-8875513 6.362851e-03 2.196 0 0
G2/M Transition R-HSA-69275 6.558247e-03 2.183 1 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.863286e-03 2.163 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.890148e-03 2.162 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.890148e-03 2.162 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 7.237199e-03 2.140 0 0
Nucleotide Excision Repair R-HSA-5696398 7.462645e-03 2.127 1 0
Generic Transcription Pathway R-HSA-212436 7.853563e-03 2.105 1 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.855129e-03 2.105 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.855129e-03 2.105 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.855129e-03 2.105 0 0
Signaling by RAS mutants R-HSA-6802949 7.855129e-03 2.105 0 0
DNA strand elongation R-HSA-69190 8.144628e-03 2.089 0 0
Regulation of TP53 Activity R-HSA-5633007 8.246950e-03 2.084 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.254147e-03 2.083 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 9.880808e-03 2.005 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 9.880808e-03 2.005 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 9.880808e-03 2.005 0 0
Diseases of Telomere Maintenance R-HSA-9673013 9.880808e-03 2.005 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 9.880808e-03 2.005 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 9.880808e-03 2.005 0 0
Type I hemidesmosome assembly R-HSA-446107 9.526257e-03 2.021 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 9.526257e-03 2.021 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 9.526257e-03 2.021 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.234946e-03 2.035 0 0
G1/S Transition R-HSA-69206 9.616711e-03 2.017 1 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 9.415580e-03 2.026 1 1
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 9.526257e-03 2.021 0 0
Glycolysis R-HSA-70171 9.907907e-03 2.004 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.018919e-02 1.992 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 1.041602e-02 1.982 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.041602e-02 1.982 0 0
Separation of Sister Chromatids R-HSA-2467813 1.050025e-02 1.979 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.052194e-02 1.978 0 0
Death Receptor Signaling R-HSA-73887 1.069412e-02 1.971 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.135926e-02 1.945 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.155399e-02 1.937 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.158317e-02 1.936 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.246929e-02 1.904 0 0
DCC mediated attractive signaling R-HSA-418885 1.430753e-02 1.844 0 0
Selective autophagy R-HSA-9663891 1.499242e-02 1.824 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.567266e-02 1.805 0 0
IRS activation R-HSA-74713 1.567266e-02 1.805 0 0
G2 Phase R-HSA-68911 1.567266e-02 1.805 0 0
Host Interactions of HIV factors R-HSA-162909 1.643892e-02 1.784 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.723478e-02 1.764 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.118177e-02 1.674 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.118177e-02 1.674 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.118177e-02 1.674 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.118177e-02 1.674 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.896584e-02 1.722 0 0
Activation of the pre-replicative complex R-HSA-68962 1.896584e-02 1.722 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.938348e-02 1.713 0 0
FOXO-mediated transcription R-HSA-9614085 1.904834e-02 1.720 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.118177e-02 1.674 0 0
HCMV Infection R-HSA-9609646 2.010872e-02 1.697 0 0
Vesicle-mediated transport R-HSA-5653656 1.896241e-02 1.722 0 0
Axon guidance R-HSA-422475 1.869216e-02 1.728 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.014637e-02 1.696 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.217245e-02 1.654 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.239739e-02 1.650 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.268798e-02 1.644 1 1
NRAGE signals death through JNK R-HSA-193648 2.268798e-02 1.644 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.277445e-02 1.643 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.343147e-02 1.630 0 0
Signaling by NTRKs R-HSA-166520 2.509860e-02 1.600 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.541997e-02 1.595 1 1
Aggrephagy R-HSA-9646399 2.541997e-02 1.595 0 0
Chromosome Maintenance R-HSA-73886 2.581643e-02 1.588 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.623757e-02 1.581 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.699318e-02 1.569 0 0
Nervous system development R-HSA-9675108 2.730826e-02 1.564 0 0
Nuclear RNA decay R-HSA-9930044 2.763361e-02 1.559 0 0
Gap junction trafficking and regulation R-HSA-157858 2.800382e-02 1.553 0 0
FLT3 Signaling R-HSA-9607240 2.827260e-02 1.549 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.992696e-02 1.524 0 0
MET activates RAS signaling R-HSA-8851805 3.210136e-02 1.493 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.210136e-02 1.493 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.939970e-02 1.532 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.430721e-02 1.465 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.103607e-02 1.508 0 0
Signaling by MET R-HSA-6806834 3.339785e-02 1.476 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.332609e-02 1.477 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.310146e-02 1.480 1 1
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.339785e-02 1.476 1 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.462541e-02 1.461 1 1
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.332609e-02 1.477 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.228345e-02 1.491 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.103607e-02 1.508 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.309380e-02 1.480 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.151905e-02 1.501 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.151905e-02 1.501 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.210136e-02 1.493 0 0
Gene Silencing by RNA R-HSA-211000 3.440630e-02 1.463 0 0
RAF activation R-HSA-5673000 3.470869e-02 1.460 0 0
L1CAM interactions R-HSA-373760 3.555751e-02 1.449 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.573026e-02 1.447 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.573026e-02 1.447 1 1
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.588897e-02 1.445 0 0
Regulation of TP53 Expression R-HSA-6804754 3.588897e-02 1.445 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.588897e-02 1.445 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.588897e-02 1.445 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.588897e-02 1.445 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.588897e-02 1.445 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.588897e-02 1.445 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.588897e-02 1.445 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.588897e-02 1.445 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.588897e-02 1.445 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.588897e-02 1.445 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.588897e-02 1.445 0 0
Diseases of Cellular Senescence R-HSA-9630747 3.588897e-02 1.445 0 0
Diseases of cellular response to stress R-HSA-9675132 3.588897e-02 1.445 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.588897e-02 1.445 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.740397e-02 1.427 0 0
Glucose metabolism R-HSA-70326 3.765062e-02 1.424 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.850233e-02 1.415 1 1
Signalling to ERKs R-HSA-187687 3.865843e-02 1.413 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.892453e-02 1.410 0 0
Regulation of PTEN localization R-HSA-8948747 3.892453e-02 1.410 0 0
SOS-mediated signalling R-HSA-112412 3.892453e-02 1.410 0 0
Negative regulation of MET activity R-HSA-6807004 3.969313e-02 1.401 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.142082e-02 1.383 0 0
Influenza Infection R-HSA-168255 4.159438e-02 1.381 0 0
Gap junction trafficking R-HSA-190828 4.188055e-02 1.378 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.254616e-02 1.371 1 1
Formation of the Early Elongation Complex R-HSA-113418 4.254616e-02 1.371 1 1
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.346104e-02 1.272 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.595463e-02 1.338 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.595463e-02 1.338 0 0
Lagging Strand Synthesis R-HSA-69186 4.556484e-02 1.341 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.192685e-02 1.285 0 0
HDACs deacetylate histones R-HSA-3214815 4.736728e-02 1.325 0 0
Centrosome maturation R-HSA-380287 4.770886e-02 1.321 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.289141e-02 1.368 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.192685e-02 1.285 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.322450e-02 1.274 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.192685e-02 1.285 0 0
PTEN Regulation R-HSA-6807070 4.550050e-02 1.342 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.406521e-02 1.356 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.249401e-02 1.280 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.346104e-02 1.272 0 0
Regulation of KIT signaling R-HSA-1433559 4.595463e-02 1.338 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.741288e-02 1.324 0 0
Macroautophagy R-HSA-1632852 5.018259e-02 1.299 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.788059e-02 1.320 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.128594e-02 1.290 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.550050e-02 1.342 0 0
Adherens junctions interactions R-HSA-418990 5.387297e-02 1.269 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.394687e-02 1.268 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.394687e-02 1.268 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.394687e-02 1.268 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.394687e-02 1.268 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.519563e-02 1.258 0 0
MAPK family signaling cascades R-HSA-5683057 5.603172e-02 1.252 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.733777e-02 1.242 1 1
Nuclear Receptor transcription pathway R-HSA-383280 5.830706e-02 1.234 0 0
Interferon Signaling R-HSA-913531 5.845337e-02 1.233 0 0
EGFR downregulation R-HSA-182971 5.912090e-02 1.228 0 0
Transcription of the HIV genome R-HSA-167172 5.932865e-02 1.227 1 1
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.932865e-02 1.227 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.974617e-02 1.224 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.044695e-02 1.219 0 0
Diseases of programmed cell death R-HSA-9645723 6.044695e-02 1.219 0 0
ARMS-mediated activation R-HSA-170984 6.051172e-02 1.218 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 6.051172e-02 1.218 0 0
GP1b-IX-V activation signalling R-HSA-430116 6.051172e-02 1.218 0 0
Lipophagy R-HSA-9613354 6.051172e-02 1.218 0 0
Unwinding of DNA R-HSA-176974 6.051172e-02 1.218 0 0
Telomere Maintenance R-HSA-157579 6.193085e-02 1.208 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.237607e-02 1.205 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.264149e-02 1.203 0 0
Prolonged ERK activation events R-HSA-169893 6.264149e-02 1.203 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.274714e-02 1.202 1 1
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.274714e-02 1.202 1 1
HIV Transcription Elongation R-HSA-167169 6.274714e-02 1.202 1 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.274714e-02 1.202 1 1
Extension of Telomeres R-HSA-180786 6.429241e-02 1.192 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.539131e-02 1.184 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.612610e-02 1.180 1 1
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.612610e-02 1.180 1 1
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.612610e-02 1.180 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.905179e-02 1.161 0 0
Signaling by ERBB2 R-HSA-1227986 6.905179e-02 1.161 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 7.117921e-02 1.148 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 7.117921e-02 1.148 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 7.117921e-02 1.148 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 7.117921e-02 1.148 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.203575e-02 1.142 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.242492e-02 1.140 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.299818e-02 1.137 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.299818e-02 1.137 0 0
Regulation of gap junction activity R-HSA-191650 7.341632e-02 1.134 0 0
NADE modulates death signalling R-HSA-205025 7.341632e-02 1.134 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 7.341632e-02 1.134 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 7.341632e-02 1.134 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 7.341632e-02 1.134 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 9.532712e-02 1.021 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 9.532712e-02 1.021 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 9.532712e-02 1.021 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.652742e-02 1.063 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.208236e-02 1.086 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.278954e-02 1.033 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.446762e-02 1.128 1 1
HIV Transcription Initiation R-HSA-167161 7.446762e-02 1.128 1 1
RNA Polymerase II Transcription Initiation R-HSA-75953 7.446762e-02 1.128 1 1
RNA Polymerase II Promoter Escape R-HSA-73776 8.739010e-02 1.059 1 1
mRNA 3'-end processing R-HSA-72187 8.057182e-02 1.094 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.653080e-02 1.063 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.461880e-02 1.073 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.461880e-02 1.073 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.250910e-02 1.034 1 1
Polo-like kinase mediated events R-HSA-156711 9.278954e-02 1.033 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.208236e-02 1.086 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.643958e-02 1.063 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.395889e-02 1.131 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.278954e-02 1.033 0 0
Mismatch Repair R-HSA-5358508 9.278954e-02 1.033 0 0
EPH-Ephrin signaling R-HSA-2682334 8.043763e-02 1.095 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.446762e-02 1.128 0 0
Protein folding R-HSA-391251 8.043763e-02 1.095 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.077909e-02 1.093 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.921444e-02 1.101 0 0
Developmental Biology R-HSA-1266738 9.070073e-02 1.042 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.923955e-02 1.049 0 0
MHC class II antigen presentation R-HSA-2132295 8.871906e-02 1.052 0 0
Specification of primordial germ cells R-HSA-9827857 8.208236e-02 1.086 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 9.278954e-02 1.033 0 0
Interleukin-12 signaling R-HSA-9020591 9.800064e-02 1.009 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.919796e-02 1.003 0 0
Autophagy R-HSA-9612973 1.001758e-01 0.999 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.003116e-01 0.999 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.003116e-01 0.999 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.003116e-01 0.999 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.003116e-01 0.999 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.010261e-01 0.996 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.010261e-01 0.996 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.010261e-01 0.996 0 0
NF-kB is activated and signals survival R-HSA-209560 1.010261e-01 0.996 0 0
Activation of RAC1 R-HSA-428540 1.010261e-01 0.996 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 1.015015e-01 0.994 1 1
AURKA Activation by TPX2 R-HSA-8854518 1.021211e-01 0.991 0 0
G1/S-Specific Transcription R-HSA-69205 1.023042e-01 0.990 0 0
RET signaling R-HSA-8853659 1.023042e-01 0.990 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.041220e-01 0.982 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.041626e-01 0.982 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.041626e-01 0.982 0 0
Post NMDA receptor activation events R-HSA-438064 1.042706e-01 0.982 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.042706e-01 0.982 0 0
Signaling by ROBO receptors R-HSA-376176 1.054183e-01 0.977 0 0
TNF signaling R-HSA-75893 1.059026e-01 0.975 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.089951e-01 0.963 0 0
HIV elongation arrest and recovery R-HSA-167287 1.100126e-01 0.959 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.100126e-01 0.959 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.104046e-01 0.957 0 0
Cell-cell junction organization R-HSA-421270 1.107330e-01 0.956 0 0
DNA Repair R-HSA-73894 1.116030e-01 0.952 1 0
Sensory processing of sound R-HSA-9659379 1.155947e-01 0.937 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.160511e-01 0.935 0 0
Formation of definitive endoderm R-HSA-9823730 1.160511e-01 0.935 0 0
Polymerase switching R-HSA-69091 1.164162e-01 0.934 0 0
Leading Strand Synthesis R-HSA-69109 1.164162e-01 0.934 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.164162e-01 0.934 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.188145e-01 0.925 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.188145e-01 0.925 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.188145e-01 0.925 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.188145e-01 0.925 0 0
Dual incision in TC-NER R-HSA-6782135 1.200404e-01 0.921 1 1
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.200404e-01 0.921 0 0
mRNA Capping R-HSA-72086 1.201496e-01 0.920 1 1
PKR-mediated signaling R-HSA-9833482 1.218280e-01 0.914 0 0
NGF-stimulated transcription R-HSA-9031628 1.248351e-01 0.904 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.248351e-01 0.904 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.287274e-01 0.890 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.372959e-01 0.862 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.372959e-01 0.862 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.372959e-01 0.862 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.372959e-01 0.862 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.435433e-01 0.843 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.435433e-01 0.843 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.435433e-01 0.843 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.692184e-01 0.772 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.692184e-01 0.772 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.692184e-01 0.772 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.692184e-01 0.772 0 0
Formation of axial mesoderm R-HSA-9796292 1.326169e-01 0.877 0 0
Removal of the Flap Intermediate R-HSA-69166 1.495456e-01 0.825 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.495456e-01 0.825 0 0
Erythropoietin activates RAS R-HSA-9027284 1.671197e-01 0.777 0 0
Phosphorylation of the APC/C R-HSA-176412 1.852573e-01 0.732 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.852573e-01 0.732 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.852573e-01 0.732 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.307068e-01 0.884 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.834831e-01 0.736 0 0
Dual Incision in GG-NER R-HSA-5696400 1.891383e-01 0.723 0 0
Translation initiation complex formation R-HSA-72649 1.786975e-01 0.748 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.711791e-01 0.767 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.829142e-01 0.738 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.348357e-01 0.870 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.711791e-01 0.767 0 0
p75NTR signals via NF-kB R-HSA-193639 1.671197e-01 0.777 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.425146e-01 0.846 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.326169e-01 0.877 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.955799e-01 0.709 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 1.580791e-01 0.801 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.692184e-01 0.772 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.550953e-01 0.809 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.891383e-01 0.723 0 0
Killing mechanisms R-HSA-9664420 1.852573e-01 0.732 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 1.852573e-01 0.732 0 0
Synthesis of DNA R-HSA-69239 1.760354e-01 0.754 0 0
Integrin signaling R-HSA-354192 1.647171e-01 0.783 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.561788e-01 0.806 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.561788e-01 0.806 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.550953e-01 0.809 0 0
RNA Polymerase I Transcription R-HSA-73864 1.904150e-01 0.720 1 0
Homology Directed Repair R-HSA-5693538 1.842125e-01 0.735 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.690781e-01 0.772 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.738240e-01 0.760 1 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.829142e-01 0.738 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.376345e-01 0.861 0 0
MAP kinase activation R-HSA-450294 1.430115e-01 0.845 0 0
Signaling by SCF-KIT R-HSA-1433557 1.791180e-01 0.747 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.856535e-01 0.731 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.850623e-01 0.733 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.407350e-01 0.852 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.604799e-01 0.795 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.834831e-01 0.736 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.648405e-01 0.783 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.900384e-01 0.721 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.955799e-01 0.709 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.430115e-01 0.845 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.498288e-01 0.824 0 0
Frs2-mediated activation R-HSA-170968 1.326169e-01 0.877 0 0
Netrin-1 signaling R-HSA-373752 1.900384e-01 0.721 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.416664e-01 0.849 0 0
Kinesins R-HSA-983189 1.351252e-01 0.869 0 0
Generation of second messenger molecules R-HSA-202433 1.382004e-01 0.859 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.594451e-01 0.797 0 0
Signaling by PTK6 R-HSA-8848021 1.594451e-01 0.797 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.415722e-01 0.849 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.479883e-01 0.830 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.435433e-01 0.843 0 0
TBC/RABGAPs R-HSA-8854214 1.791180e-01 0.747 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.692184e-01 0.772 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.692847e-01 0.771 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.900384e-01 0.721 0 0
SARS-CoV Infections R-HSA-9679506 1.746311e-01 0.758 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.541833e-01 0.812 0 0
Interleukin-12 family signaling R-HSA-447115 1.779821e-01 0.750 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.982717e-01 0.703 0 0
Acyl chain remodelling of PS R-HSA-1482801 1.982717e-01 0.703 0 0
HDMs demethylate histones R-HSA-3214842 1.982717e-01 0.703 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.985417e-01 0.702 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 1.987098e-01 0.702 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 1.987098e-01 0.702 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 1.987098e-01 0.702 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.987098e-01 0.702 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.987098e-01 0.702 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.987098e-01 0.702 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.987098e-01 0.702 0 0
Transport of connexins along the secretory pathway R-HSA-190827 1.987098e-01 0.702 0 0
Oligomerization of connexins into connexons R-HSA-190704 1.987098e-01 0.702 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.012068e-01 0.696 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.016906e-01 0.695 0 0
Base Excision Repair R-HSA-73884 2.016906e-01 0.695 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.038780e-01 0.691 0 0
Disorders of Developmental Biology R-HSA-9675151 2.038780e-01 0.691 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.038780e-01 0.691 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.040819e-01 0.690 0 0
Adipogenesis R-HSA-9843745 2.044905e-01 0.689 0 0
Regulation of CDH1 Function R-HSA-9764561 2.087739e-01 0.680 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.135597e-01 0.670 0 0
HSF1 activation R-HSA-3371511 2.147535e-01 0.668 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.189925e-01 0.660 0 0
Viral Infection Pathways R-HSA-9824446 2.218437e-01 0.654 1 0
Regulated proteolysis of p75NTR R-HSA-193692 2.224004e-01 0.653 0 0
WNT mediated activation of DVL R-HSA-201688 2.224004e-01 0.653 0 0
Calcineurin activates NFAT R-HSA-2025928 2.224004e-01 0.653 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.224004e-01 0.653 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.224004e-01 0.653 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 2.224004e-01 0.653 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.224004e-01 0.653 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.224004e-01 0.653 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.229037e-01 0.652 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.229037e-01 0.652 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.229037e-01 0.652 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.229037e-01 0.652 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.229037e-01 0.652 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.557553e-01 0.592 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.557553e-01 0.592 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.557553e-01 0.592 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.557553e-01 0.592 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.557553e-01 0.592 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.087427e-01 0.510 0 0
Axonal growth stimulation R-HSA-209563 3.087427e-01 0.510 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.087427e-01 0.510 0 0
MET activates PTPN11 R-HSA-8865999 3.087427e-01 0.510 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.087427e-01 0.510 0 0
Invadopodia formation R-HSA-8941237 3.087427e-01 0.510 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.087427e-01 0.510 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.087427e-01 0.510 0 0
HCN channels R-HSA-1296061 3.579606e-01 0.446 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.579606e-01 0.446 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.579606e-01 0.446 0 0
Signaling by MAP2K mutants R-HSA-9652169 3.579606e-01 0.446 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.494811e-01 0.603 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.494811e-01 0.603 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.494811e-01 0.603 0 0
Signaling by APC mutants R-HSA-4839744 2.766492e-01 0.558 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.766492e-01 0.558 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.766492e-01 0.558 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.766492e-01 0.558 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.036769e-01 0.394 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.037553e-01 0.517 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.037553e-01 0.517 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.037553e-01 0.517 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.422592e-01 0.616 0 0
Regulation of signaling by CBL R-HSA-912631 2.618724e-01 0.582 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.618724e-01 0.582 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.306707e-01 0.481 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.306707e-01 0.481 0 0
Repression of WNT target genes R-HSA-4641265 3.306707e-01 0.481 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.306707e-01 0.481 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.306707e-01 0.481 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.306707e-01 0.481 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.306707e-01 0.481 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.306707e-01 0.481 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.306707e-01 0.481 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 4.461405e-01 0.351 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.461405e-01 0.351 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.461405e-01 0.351 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 4.461405e-01 0.351 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.461405e-01 0.351 0 0
Signaling by RNF43 mutants R-HSA-5340588 4.461405e-01 0.351 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 2.288449e-01 0.640 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.016010e-01 0.521 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.604886e-01 0.584 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.604886e-01 0.584 0 0
MET promotes cell motility R-HSA-8875878 2.413778e-01 0.617 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.215908e-01 0.493 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.835052e-01 0.416 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.929011e-01 0.533 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.092523e-01 0.388 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.092523e-01 0.388 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.092523e-01 0.388 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.615363e-01 0.442 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.615363e-01 0.442 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.257940e-01 0.487 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.850190e-01 0.545 1 1
Deadenylation of mRNA R-HSA-429947 3.813901e-01 0.419 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.813901e-01 0.419 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.813901e-01 0.419 0 0
Translesion synthesis by POLI R-HSA-5656121 4.344607e-01 0.362 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.976034e-01 0.526 0 0
Nucleosome assembly R-HSA-774815 3.542157e-01 0.451 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.542157e-01 0.451 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.686594e-01 0.433 1 1
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.399470e-01 0.357 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.399470e-01 0.357 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.797784e-01 0.553 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.706689e-01 0.568 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.206347e-01 0.376 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.456559e-01 0.461 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.703888e-01 0.431 1 1
NRIF signals cell death from the nucleus R-HSA-205043 3.835052e-01 0.416 0 0
DNA Damage Bypass R-HSA-73893 4.119396e-01 0.385 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.298036e-01 0.639 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.331901e-01 0.363 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.375514e-01 0.472 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.034574e-01 0.394 1 1
PI3K/AKT activation R-HSA-198203 2.494811e-01 0.603 0 0
Translesion synthesis by REV1 R-HSA-110312 4.092523e-01 0.388 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.344607e-01 0.362 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.331901e-01 0.363 0 0
Regulation of IFNG signaling R-HSA-877312 3.306707e-01 0.481 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.306707e-01 0.481 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.288449e-01 0.640 1 1
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.771009e-01 0.557 0 0
Signal transduction by L1 R-HSA-445144 2.816746e-01 0.550 0 0
UCH proteinases R-HSA-5689603 4.262431e-01 0.370 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.302088e-01 0.481 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.428831e-01 0.615 0 0
IGF1R signaling cascade R-HSA-2428924 2.851335e-01 0.545 0 0
DNA Double Strand Break Response R-HSA-5693606 3.197405e-01 0.495 0 0
Meiosis R-HSA-1500620 3.813981e-01 0.419 0 0
Formation of the posterior neural plate R-HSA-9832991 2.766492e-01 0.558 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 4.036769e-01 0.394 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.011033e-01 0.397 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.542157e-01 0.451 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.831075e-01 0.417 0 0
Ephrin signaling R-HSA-3928664 2.422592e-01 0.616 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.965760e-01 0.528 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.572852e-01 0.447 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.579606e-01 0.446 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.579606e-01 0.446 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.461405e-01 0.351 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.288449e-01 0.640 0 0
Signalling to RAS R-HSA-167044 3.016010e-01 0.521 0 0
Degradation of CDH1 R-HSA-9766229 4.119396e-01 0.385 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.906069e-01 0.408 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.136600e-01 0.383 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.857754e-01 0.544 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.816746e-01 0.550 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.827936e-01 0.549 0 0
Interleukin-17 signaling R-HSA-448424 2.232019e-01 0.651 0 0
Myogenesis R-HSA-525793 4.206347e-01 0.376 0 0
Gap junction assembly R-HSA-190861 3.588973e-01 0.445 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.831075e-01 0.417 0 0
DNA Replication R-HSA-69306 3.857099e-01 0.414 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.422592e-01 0.616 0 0
HATs acetylate histones R-HSA-3214847 4.245473e-01 0.372 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.787211e-01 0.422 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.257940e-01 0.487 0 0
MET activates STAT3 R-HSA-8875791 3.087427e-01 0.510 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.087427e-01 0.510 0 0
Bicarbonate transporters R-HSA-425381 2.766492e-01 0.558 0 0
Reelin signalling pathway R-HSA-8866376 4.036769e-01 0.394 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.036769e-01 0.394 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.037553e-01 0.517 0 0
Signaling by AXIN mutants R-HSA-4839735 3.037553e-01 0.517 0 0
Phosphorylation of Emi1 R-HSA-176417 4.461405e-01 0.351 0 0
Ceramide signalling R-HSA-193681 4.461405e-01 0.351 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.572852e-01 0.447 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.092523e-01 0.388 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.092523e-01 0.388 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.615363e-01 0.442 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.257940e-01 0.487 0 0
Signaling by VEGF R-HSA-194138 2.406980e-01 0.619 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.863633e-01 0.543 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.454423e-01 0.462 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.945277e-01 0.531 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.945277e-01 0.531 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.515970e-01 0.599 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.092523e-01 0.388 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.206347e-01 0.376 0 0
PTK6 Activates STAT3 R-HSA-8849474 4.036769e-01 0.394 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.016010e-01 0.521 0 0
Rap1 signalling R-HSA-392517 2.618724e-01 0.582 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.787211e-01 0.422 0 0
HCMV Late Events R-HSA-9610379 2.284953e-01 0.641 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.615363e-01 0.442 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.142100e-01 0.383 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.142100e-01 0.383 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.142100e-01 0.383 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.036769e-01 0.394 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.037553e-01 0.517 0 0
Disorders of Nervous System Development R-HSA-9697154 3.306707e-01 0.481 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.306707e-01 0.481 0 0
Pervasive developmental disorders R-HSA-9005895 3.306707e-01 0.481 0 0
Heme signaling R-HSA-9707616 4.136600e-01 0.383 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.016010e-01 0.521 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.016010e-01 0.521 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.206347e-01 0.376 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.604886e-01 0.584 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.533022e-01 0.596 0 0
TGFBR3 expression R-HSA-9839394 4.011033e-01 0.397 0 0
Rab regulation of trafficking R-HSA-9007101 3.759148e-01 0.425 0 0
TCR signaling R-HSA-202403 2.945277e-01 0.531 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.429456e-01 0.614 0 0
Interleukin-15 signaling R-HSA-8983432 3.306707e-01 0.481 0 0
Deubiquitination R-HSA-5688426 3.020450e-01 0.520 0 0
Semaphorin interactions R-HSA-373755 2.738003e-01 0.563 0 0
Reproduction R-HSA-1474165 3.943963e-01 0.404 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.087427e-01 0.510 0 0
Sensory perception of sour taste R-HSA-9729555 3.579606e-01 0.446 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 3.579606e-01 0.446 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.461405e-01 0.351 0 0
Negative regulation of FLT3 R-HSA-9706369 4.344607e-01 0.362 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.405322e-01 0.356 0 0
RMTs methylate histone arginines R-HSA-3214858 3.397967e-01 0.469 0 0
Signaling by FGFR4 R-HSA-5654743 3.254231e-01 0.488 0 0
Signaling by FGFR3 R-HSA-5654741 3.542157e-01 0.451 0 0
Carnitine shuttle R-HSA-200425 3.615363e-01 0.442 0 0
Suppression of apoptosis R-HSA-9635465 2.766492e-01 0.558 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.579606e-01 0.446 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 4.461405e-01 0.351 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 4.461405e-01 0.351 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.215908e-01 0.493 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.550095e-01 0.593 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.206347e-01 0.376 0 0
Potential therapeutics for SARS R-HSA-9679191 2.649477e-01 0.577 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.321900e-01 0.479 0 0
Interleukin-2 signaling R-HSA-9020558 2.766492e-01 0.558 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.206347e-01 0.376 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.036769e-01 0.394 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.461405e-01 0.351 0 0
Basigin interactions R-HSA-210991 3.016010e-01 0.521 0 0
Signal regulatory protein family interactions R-HSA-391160 3.835052e-01 0.416 0 0
Formation of the anterior neural plate R-HSA-9823739 4.092523e-01 0.388 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.247647e-01 0.372 0 0
Signaling by ALK R-HSA-201556 4.410038e-01 0.356 0 0
Josephin domain DUBs R-HSA-5689877 2.494811e-01 0.603 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.572852e-01 0.447 0 0
Miscellaneous transport and binding events R-HSA-5223345 3.423354e-01 0.466 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.399470e-01 0.357 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.036769e-01 0.394 0 0
OAS antiviral response R-HSA-8983711 3.306707e-01 0.481 0 0
Signaling by Leptin R-HSA-2586552 2.494811e-01 0.603 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 3.572852e-01 0.447 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.626479e-01 0.441 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 3.835052e-01 0.416 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 3.747367e-01 0.426 0 0
tRNA processing R-HSA-72306 2.391777e-01 0.621 0 0
G alpha (12/13) signalling events R-HSA-416482 3.051946e-01 0.515 0 0
SLC transporter disorders R-HSA-5619102 2.967014e-01 0.528 0 0
Orc1 removal from chromatin R-HSA-68949 4.547578e-01 0.342 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.547578e-01 0.342 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.571042e-01 0.340 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.571042e-01 0.340 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.571042e-01 0.340 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.571042e-01 0.340 0 0
Interleukin-2 family signaling R-HSA-451927 4.571042e-01 0.340 0 0
Telomere Extension By Telomerase R-HSA-171319 4.590063e-01 0.338 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.590063e-01 0.338 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.590768e-01 0.338 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 4.590768e-01 0.338 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.590768e-01 0.338 0 0
Translesion synthesis by POLK R-HSA-5655862 4.590768e-01 0.338 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.590768e-01 0.338 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.590768e-01 0.338 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.590768e-01 0.338 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.590768e-01 0.338 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.590768e-01 0.338 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.590768e-01 0.338 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.657739e-01 0.332 0 0
Meiotic synapsis R-HSA-1221632 4.688497e-01 0.329 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.720509e-01 0.326 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.730450e-01 0.325 0 0
Signaling by FGFR2 R-HSA-5654738 4.733243e-01 0.325 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.777612e-01 0.321 0 0
Signaling by Erythropoietin R-HSA-9006335 4.777823e-01 0.321 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.777823e-01 0.321 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.777823e-01 0.321 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.777823e-01 0.321 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.830571e-01 0.316 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.830571e-01 0.316 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.830571e-01 0.316 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 4.830571e-01 0.316 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.849534e-01 0.314 0 0
Signaling by LTK in cancer R-HSA-9842640 4.855826e-01 0.314 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.855826e-01 0.314 0 0
Autointegration results in viral DNA circles R-HSA-177539 4.855826e-01 0.314 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 4.855826e-01 0.314 0 0
MET Receptor Activation R-HSA-6806942 4.855826e-01 0.314 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 4.855826e-01 0.314 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.855826e-01 0.314 0 0
CREB phosphorylation R-HSA-199920 4.855826e-01 0.314 0 0
NADPH regeneration R-HSA-389542 4.855826e-01 0.314 0 0
Nef and signal transduction R-HSA-164944 4.855826e-01 0.314 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 4.855826e-01 0.314 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.888066e-01 0.311 0 0
DAP12 signaling R-HSA-2424491 4.962482e-01 0.304 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.962482e-01 0.304 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.962482e-01 0.304 0 0
Mitochondrial biogenesis R-HSA-1592230 5.008623e-01 0.300 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.043711e-01 0.297 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.063674e-01 0.296 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.063674e-01 0.296 0 0
Platelet sensitization by LDL R-HSA-432142 5.063674e-01 0.296 0 0
Tie2 Signaling R-HSA-210993 5.063674e-01 0.296 0 0
GAB1 signalosome R-HSA-180292 5.063674e-01 0.296 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.103750e-01 0.292 0 0
Signaling by FGFR1 R-HSA-5654736 5.103785e-01 0.292 0 0
Trafficking of AMPA receptors R-HSA-399719 5.143801e-01 0.289 0 0
Cargo concentration in the ER R-HSA-5694530 5.143801e-01 0.289 0 0
Budding and maturation of HIV virion R-HSA-162588 5.143801e-01 0.289 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.152338e-01 0.288 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.197221e-01 0.284 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.198344e-01 0.284 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.198344e-01 0.284 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 5.222182e-01 0.282 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 5.222182e-01 0.282 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 5.222182e-01 0.282 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.222182e-01 0.282 0 0
Recycling of eIF2:GDP R-HSA-72731 5.222182e-01 0.282 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.222182e-01 0.282 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.222182e-01 0.282 0 0
VLDL clearance R-HSA-8964046 5.222182e-01 0.282 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.222182e-01 0.282 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.222182e-01 0.282 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.229932e-01 0.282 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.262554e-01 0.279 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.274977e-01 0.278 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.274977e-01 0.278 0 0
Translesion Synthesis by POLH R-HSA-110320 5.289815e-01 0.277 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.289815e-01 0.277 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.289815e-01 0.277 0 0
The NLRP3 inflammasome R-HSA-844456 5.289815e-01 0.277 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 5.289815e-01 0.277 0 0
ESR-mediated signaling R-HSA-8939211 5.290587e-01 0.276 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.313994e-01 0.275 0 0
Signaling by WNT in cancer R-HSA-4791275 5.321573e-01 0.274 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.321573e-01 0.274 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.358398e-01 0.271 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.361275e-01 0.271 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.396331e-01 0.268 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.418292e-01 0.266 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.478465e-01 0.261 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.478465e-01 0.261 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.495618e-01 0.260 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.495618e-01 0.260 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.505244e-01 0.259 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.508804e-01 0.259 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.508804e-01 0.259 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.508804e-01 0.259 0 0
Nephrin family interactions R-HSA-373753 5.508804e-01 0.259 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 5.508804e-01 0.259 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 5.562467e-01 0.255 0 0
phospho-PLA2 pathway R-HSA-111995 5.562467e-01 0.255 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.562467e-01 0.255 0 0
MET receptor recycling R-HSA-8875656 5.562467e-01 0.255 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.562467e-01 0.255 0 0
Adrenoceptors R-HSA-390696 5.562467e-01 0.255 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.562467e-01 0.255 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 5.562467e-01 0.255 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.562467e-01 0.255 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.562467e-01 0.255 0 0
Sodium/Proton exchangers R-HSA-425986 5.562467e-01 0.255 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.640043e-01 0.249 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.643516e-01 0.248 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.643516e-01 0.248 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.643516e-01 0.248 0 0
Striated Muscle Contraction R-HSA-390522 5.665784e-01 0.247 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.665784e-01 0.247 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.720511e-01 0.243 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.720511e-01 0.243 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.720511e-01 0.243 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.720511e-01 0.243 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.748106e-01 0.240 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.751891e-01 0.240 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.751891e-01 0.240 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.757782e-01 0.240 0 0
Cilium Assembly R-HSA-5617833 5.788088e-01 0.237 0 0
Mitophagy R-HSA-5205647 5.831944e-01 0.234 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.831944e-01 0.234 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.841889e-01 0.233 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.841889e-01 0.233 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.841889e-01 0.233 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.846149e-01 0.233 0 0
Toll-like Receptor Cascades R-HSA-168898 5.861362e-01 0.232 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.878535e-01 0.231 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.878535e-01 0.231 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.878535e-01 0.231 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.878535e-01 0.231 0 0
Interleukin-1 processing R-HSA-448706 5.878535e-01 0.231 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.878535e-01 0.231 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.878535e-01 0.231 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 5.878535e-01 0.231 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.890071e-01 0.230 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.890071e-01 0.230 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.924865e-01 0.227 0 0
Intraflagellar transport R-HSA-5620924 5.928004e-01 0.227 0 0
Co-stimulation by CD28 R-HSA-389356 5.928004e-01 0.227 0 0
PI Metabolism R-HSA-1483255 5.945171e-01 0.226 0 0
Regulation of Apoptosis R-HSA-169911 5.993993e-01 0.222 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.993993e-01 0.222 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.993993e-01 0.222 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.993993e-01 0.222 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.993993e-01 0.222 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.014262e-01 0.221 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.063679e-01 0.217 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.066049e-01 0.217 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.066049e-01 0.217 0 0
Developmental Cell Lineages R-HSA-9734767 6.085045e-01 0.216 0 0
FGFR2 alternative splicing R-HSA-6803529 6.121837e-01 0.213 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.121837e-01 0.213 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.121837e-01 0.213 0 0
Signaling by KIT in disease R-HSA-9669938 6.121837e-01 0.213 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.121837e-01 0.213 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.121837e-01 0.213 0 0
LDL clearance R-HSA-8964038 6.121837e-01 0.213 0 0
Insulin receptor signalling cascade R-HSA-74751 6.136297e-01 0.212 0 0
RUNX2 regulates bone development R-HSA-8941326 6.151849e-01 0.211 0 0
FLT3 signaling in disease R-HSA-9682385 6.151849e-01 0.211 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.172108e-01 0.210 0 0
DNA replication initiation R-HSA-68952 6.172108e-01 0.210 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.172108e-01 0.210 0 0
Regulation of CDH11 function R-HSA-9762292 6.172108e-01 0.210 0 0
Binding and entry of HIV virion R-HSA-173107 6.172108e-01 0.210 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.172108e-01 0.210 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.172108e-01 0.210 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.172108e-01 0.210 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.172108e-01 0.210 0 0
2-LTR circle formation R-HSA-164843 6.172108e-01 0.210 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.172108e-01 0.210 0 0
Arachidonate production from DAG R-HSA-426048 6.172108e-01 0.210 0 0
Pexophagy R-HSA-9664873 6.172108e-01 0.210 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.172108e-01 0.210 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 6.172108e-01 0.210 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.172108e-01 0.210 0 0
Degradation of DVL R-HSA-4641258 6.305449e-01 0.200 0 0
Collagen chain trimerization R-HSA-8948216 6.305449e-01 0.200 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.311443e-01 0.200 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 6.311443e-01 0.200 0 0
Growth hormone receptor signaling R-HSA-982772 6.311443e-01 0.200 0 0
HSF1-dependent transactivation R-HSA-3371571 6.333387e-01 0.198 0 0
Meiotic recombination R-HSA-912446 6.333387e-01 0.198 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.367683e-01 0.196 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.444787e-01 0.191 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.444787e-01 0.191 0 0
LGI-ADAM interactions R-HSA-5682910 6.444787e-01 0.191 0 0
vRNA Synthesis R-HSA-192814 6.444787e-01 0.191 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 6.444787e-01 0.191 0 0
PECAM1 interactions R-HSA-210990 6.444787e-01 0.191 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.454749e-01 0.190 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.454749e-01 0.190 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.454749e-01 0.190 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.462570e-01 0.190 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.462570e-01 0.190 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.462570e-01 0.190 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.474729e-01 0.189 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.493732e-01 0.188 0 0
Co-inhibition by PD-1 R-HSA-389948 6.494994e-01 0.187 0 0
Signaling by WNT R-HSA-195721 6.497281e-01 0.187 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.516052e-01 0.186 0 0
Circadian clock R-HSA-9909396 6.525930e-01 0.185 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.562677e-01 0.183 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.588708e-01 0.181 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.588708e-01 0.181 0 0
Smooth Muscle Contraction R-HSA-445355 6.588708e-01 0.181 0 0
Stabilization of p53 R-HSA-69541 6.599723e-01 0.180 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.599723e-01 0.180 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.626722e-01 0.179 0 0
Interleukin-7 signaling R-HSA-1266695 6.668785e-01 0.176 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.698056e-01 0.174 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.698056e-01 0.174 0 0
Integration of provirus R-HSA-162592 6.698056e-01 0.174 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 6.698056e-01 0.174 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.698056e-01 0.174 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.698056e-01 0.174 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.711770e-01 0.173 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.740359e-01 0.171 0 0
Attenuation phase R-HSA-3371568 6.740359e-01 0.171 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.810498e-01 0.167 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.820523e-01 0.166 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.820523e-01 0.166 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.820523e-01 0.166 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.831736e-01 0.165 0 0
MET activates PTK2 signaling R-HSA-8874081 6.836707e-01 0.165 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.836707e-01 0.165 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.843076e-01 0.165 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.876660e-01 0.163 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.876660e-01 0.163 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.876660e-01 0.163 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.923913e-01 0.160 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.926247e-01 0.160 0 0
Signaling by FGFR R-HSA-190236 6.933230e-01 0.159 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.933297e-01 0.159 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.933297e-01 0.159 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.933297e-01 0.159 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.933297e-01 0.159 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 6.933297e-01 0.159 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.933297e-01 0.159 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.933297e-01 0.159 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.948593e-01 0.158 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.948593e-01 0.158 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.997625e-01 0.155 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.997625e-01 0.155 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.136333e-01 0.147 0 0
Depyrimidination R-HSA-73928 7.136333e-01 0.147 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.151686e-01 0.146 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.151686e-01 0.146 0 0
Inflammasomes R-HSA-622312 7.151686e-01 0.146 0 0
Pyroptosis R-HSA-5620971 7.151686e-01 0.146 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.151792e-01 0.146 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.151792e-01 0.146 0 0
Maturation of nucleoprotein R-HSA-9683610 7.151792e-01 0.146 0 0
Interleukin-6 signaling R-HSA-1059683 7.151792e-01 0.146 0 0
Peptide chain elongation R-HSA-156902 7.203220e-01 0.142 0 0
Signaling by ERBB4 R-HSA-1236394 7.228809e-01 0.141 0 0
Defective pyroptosis R-HSA-9710421 7.259771e-01 0.139 0 0
Late endosomal microautophagy R-HSA-9615710 7.299048e-01 0.137 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.299048e-01 0.137 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.299048e-01 0.137 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.299048e-01 0.137 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.312351e-01 0.136 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.354731e-01 0.133 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.354731e-01 0.133 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.354731e-01 0.133 0 0
Hydrolysis of LPC R-HSA-1483115 7.354731e-01 0.133 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.354731e-01 0.133 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.354731e-01 0.133 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.354731e-01 0.133 0 0
Zinc transporters R-HSA-435354 7.354731e-01 0.133 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.379004e-01 0.132 0 0
DAP12 interactions R-HSA-2172127 7.379004e-01 0.132 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.439885e-01 0.128 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.439885e-01 0.128 0 0
Interleukin-37 signaling R-HSA-9008059 7.439885e-01 0.128 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.464417e-01 0.127 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.464417e-01 0.127 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.486328e-01 0.126 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.494087e-01 0.125 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.543223e-01 0.122 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.543223e-01 0.122 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.543223e-01 0.122 0 0
DNA Damage Reversal R-HSA-73942 7.543223e-01 0.122 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 7.543223e-01 0.122 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.543223e-01 0.122 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.543223e-01 0.122 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.543223e-01 0.122 0 0
p38MAPK events R-HSA-171007 7.543223e-01 0.122 0 0
Other semaphorin interactions R-HSA-416700 7.543223e-01 0.122 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.547457e-01 0.122 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.574377e-01 0.121 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.574377e-01 0.121 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.574377e-01 0.121 0 0
PCP/CE pathway R-HSA-4086400 7.598119e-01 0.119 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.605083e-01 0.119 0 0
Diseases of DNA repair R-HSA-9675135 7.605083e-01 0.119 0 0
Signaling by TGFBR3 R-HSA-9839373 7.605083e-01 0.119 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.620894e-01 0.118 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.628493e-01 0.118 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.712063e-01 0.113 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.712063e-01 0.113 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.712063e-01 0.113 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 7.718293e-01 0.112 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.718293e-01 0.112 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.718293e-01 0.112 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.718293e-01 0.112 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.718293e-01 0.112 0 0
Differentiation of T cells R-HSA-9945266 7.718293e-01 0.112 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.718293e-01 0.112 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.718293e-01 0.112 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.718293e-01 0.112 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.740952e-01 0.111 0 0
Signaling by Interleukins R-HSA-449147 7.761194e-01 0.110 0 0
Collagen formation R-HSA-1474290 7.784597e-01 0.109 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 7.815101e-01 0.107 0 0
GPER1 signaling R-HSA-9634597 7.815101e-01 0.107 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.825089e-01 0.107 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.825089e-01 0.107 0 0
G-protein beta:gamma signalling R-HSA-397795 7.825089e-01 0.107 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.825089e-01 0.107 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.825089e-01 0.107 0 0
Gastrulation R-HSA-9758941 7.867066e-01 0.104 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.880898e-01 0.103 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 7.880898e-01 0.103 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.880898e-01 0.103 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.880898e-01 0.103 0 0
Synthesis of PG R-HSA-1483148 7.880898e-01 0.103 0 0
tRNA modification in the mitochondrion R-HSA-6787450 7.880898e-01 0.103 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.932833e-01 0.101 0 0
Eukaryotic Translation Termination R-HSA-72764 7.932833e-01 0.101 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.941700e-01 0.100 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.941700e-01 0.100 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.941700e-01 0.100 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.009681e-01 0.096 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.009681e-01 0.096 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.031924e-01 0.095 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.031924e-01 0.095 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.031924e-01 0.095 0 0
Glycogen storage diseases R-HSA-3229121 8.031924e-01 0.095 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.031924e-01 0.095 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.039632e-01 0.095 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.039632e-01 0.095 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.052747e-01 0.094 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.052747e-01 0.094 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.052747e-01 0.094 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.052747e-01 0.094 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.052747e-01 0.094 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.052747e-01 0.094 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.052747e-01 0.094 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.080988e-01 0.093 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.101393e-01 0.091 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.144034e-01 0.089 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.153129e-01 0.089 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.158431e-01 0.088 0 0
PERK regulates gene expression R-HSA-381042 8.158431e-01 0.088 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.172194e-01 0.088 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.172194e-01 0.088 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.172194e-01 0.088 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.172194e-01 0.088 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.172194e-01 0.088 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.172194e-01 0.088 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.172194e-01 0.088 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 8.172194e-01 0.088 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.172194e-01 0.088 0 0
Parasite infection R-HSA-9664407 8.177281e-01 0.087 0 0
Leishmania phagocytosis R-HSA-9664417 8.177281e-01 0.087 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.177281e-01 0.087 0 0
Neurexins and neuroligins R-HSA-6794361 8.189508e-01 0.087 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.189508e-01 0.087 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.231858e-01 0.085 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.258951e-01 0.083 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.258951e-01 0.083 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.258951e-01 0.083 0 0
Glycosphingolipid transport R-HSA-9845576 8.258951e-01 0.083 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.258951e-01 0.083 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.258951e-01 0.083 0 0
RNA Polymerase III Transcription R-HSA-74158 8.258951e-01 0.083 0 0
COPII-mediated vesicle transport R-HSA-204005 8.266626e-01 0.083 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.274118e-01 0.082 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.302475e-01 0.081 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.302475e-01 0.081 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.302475e-01 0.081 0 0
Specification of the neural plate border R-HSA-9834899 8.302475e-01 0.081 0 0
Maturation of nucleoprotein R-HSA-9694631 8.302475e-01 0.081 0 0
rRNA processing R-HSA-72312 8.310693e-01 0.080 0 0
Interleukin-1 signaling R-HSA-9020702 8.331863e-01 0.079 0 0
Selenocysteine synthesis R-HSA-2408557 8.331863e-01 0.079 0 0
Cellular response to starvation R-HSA-9711097 8.353307e-01 0.078 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.354506e-01 0.078 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.354506e-01 0.078 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.355318e-01 0.078 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.419148e-01 0.075 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.423478e-01 0.075 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.423478e-01 0.075 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.423478e-01 0.075 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.423478e-01 0.075 0 0
Glycogen synthesis R-HSA-3322077 8.423478e-01 0.075 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.423478e-01 0.075 0 0
Pregnenolone biosynthesis R-HSA-196108 8.423478e-01 0.075 0 0
Protein hydroxylation R-HSA-9629569 8.423478e-01 0.075 0 0
Signaling by NODAL R-HSA-1181150 8.423478e-01 0.075 0 0
Signaling by TGFB family members R-HSA-9006936 8.448810e-01 0.073 0 0
Viral mRNA Translation R-HSA-192823 8.450286e-01 0.073 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.524558e-01 0.069 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.535861e-01 0.069 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.535861e-01 0.069 0 0
ERK/MAPK targets R-HSA-198753 8.535861e-01 0.069 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.535861e-01 0.069 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 8.535861e-01 0.069 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.535861e-01 0.069 0 0
Signaling by FGFR in disease R-HSA-1226099 8.542827e-01 0.068 0 0
IRS-mediated signalling R-HSA-112399 8.579418e-01 0.067 0 0
Protein ubiquitination R-HSA-8852135 8.605737e-01 0.065 0 0
Diseases of Immune System R-HSA-5260271 8.613338e-01 0.065 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.613338e-01 0.065 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.613338e-01 0.065 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.613338e-01 0.065 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.640240e-01 0.063 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.640240e-01 0.063 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.640240e-01 0.063 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.640240e-01 0.063 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.640240e-01 0.063 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.640240e-01 0.063 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.640240e-01 0.063 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.647942e-01 0.063 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.647942e-01 0.063 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.690971e-01 0.061 0 0
Signaling by Insulin receptor R-HSA-74752 8.710154e-01 0.060 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.713539e-01 0.060 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.730450e-01 0.059 0 0
Notch-HLH transcription pathway R-HSA-350054 8.737183e-01 0.059 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.737183e-01 0.059 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.737183e-01 0.059 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.737183e-01 0.059 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.761622e-01 0.057 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.764590e-01 0.057 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.764590e-01 0.057 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.764590e-01 0.057 0 0
Intra-Golgi traffic R-HSA-6811438 8.764590e-01 0.057 0 0
Stimuli-sensing channels R-HSA-2672351 8.764999e-01 0.057 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.776306e-01 0.057 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.827220e-01 0.054 0 0
Syndecan interactions R-HSA-3000170 8.827220e-01 0.054 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.834373e-01 0.054 0 0
Ca-dependent events R-HSA-111996 8.834373e-01 0.054 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 8.834643e-01 0.054 0 0
PLC beta mediated events R-HSA-112043 8.836338e-01 0.054 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.836338e-01 0.054 0 0
Collagen degradation R-HSA-1442490 8.836338e-01 0.054 0 0
Ribosome-associated quality control R-HSA-9948299 8.844517e-01 0.053 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.893729e-01 0.051 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.900490e-01 0.051 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.910843e-01 0.050 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.910843e-01 0.050 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.910843e-01 0.050 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.910843e-01 0.050 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.910843e-01 0.050 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.910843e-01 0.050 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.910843e-01 0.050 0 0
Interleukin-6 family signaling R-HSA-6783589 8.910843e-01 0.050 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.929113e-01 0.049 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.953128e-01 0.048 0 0
Amine ligand-binding receptors R-HSA-375280 8.963111e-01 0.048 0 0
Platelet degranulation R-HSA-114608 8.986120e-01 0.046 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.988508e-01 0.046 0 0
Long-term potentiation R-HSA-9620244 8.988508e-01 0.046 0 0
Tight junction interactions R-HSA-420029 8.988508e-01 0.046 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.988508e-01 0.046 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 8.988508e-01 0.046 0 0
Hyaluronan degradation R-HSA-2160916 8.988508e-01 0.046 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.988508e-01 0.046 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.988508e-01 0.046 0 0
Laminin interactions R-HSA-3000157 8.988508e-01 0.046 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.988508e-01 0.046 0 0
Ub-specific processing proteases R-HSA-5689880 9.000821e-01 0.046 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.000962e-01 0.046 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.012825e-01 0.045 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.022398e-01 0.045 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.022398e-01 0.045 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.022398e-01 0.045 0 0
DAG and IP3 signaling R-HSA-1489509 9.022398e-01 0.045 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.024270e-01 0.045 0 0
Interferon gamma signaling R-HSA-877300 9.046070e-01 0.044 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.056862e-01 0.043 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.060639e-01 0.043 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.060639e-01 0.043 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.078507e-01 0.042 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.078507e-01 0.042 0 0
Signaling by NOTCH R-HSA-157118 9.106333e-01 0.041 0 0
Hedgehog 'off' state R-HSA-5610787 9.117994e-01 0.040 0 0
Packaging Of Telomere Ends R-HSA-171306 9.127630e-01 0.040 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.127630e-01 0.040 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.127630e-01 0.040 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.127630e-01 0.040 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.127630e-01 0.040 0 0
Insulin processing R-HSA-264876 9.127630e-01 0.040 0 0
G-protein mediated events R-HSA-112040 9.144288e-01 0.039 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.144288e-01 0.039 0 0
Metal ion SLC transporters R-HSA-425410 9.181793e-01 0.037 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.187739e-01 0.037 0 0
Regulated Necrosis R-HSA-5218859 9.187739e-01 0.037 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.189848e-01 0.037 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.189848e-01 0.037 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.189848e-01 0.037 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.224083e-01 0.035 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.229257e-01 0.035 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.229257e-01 0.035 0 0
DNA methylation R-HSA-5334118 9.247631e-01 0.034 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.247631e-01 0.034 0 0
Platelet calcium homeostasis R-HSA-418360 9.247631e-01 0.034 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.247631e-01 0.034 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.247631e-01 0.034 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.259625e-01 0.033 0 0
PI3K Cascade R-HSA-109704 9.274116e-01 0.033 0 0
RSV-host interactions R-HSA-9833110 9.291717e-01 0.032 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.301297e-01 0.031 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.316502e-01 0.031 0 0
Interleukin-1 family signaling R-HSA-446652 9.330087e-01 0.030 0 0
Downstream TCR signaling R-HSA-202424 9.336025e-01 0.030 0 0
Infectious disease R-HSA-5663205 9.349097e-01 0.029 1 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.351137e-01 0.029 0 0
Downstream signal transduction R-HSA-186763 9.351137e-01 0.029 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.356537e-01 0.029 0 0
Ca2+ pathway R-HSA-4086398 9.376220e-01 0.028 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.397425e-01 0.027 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.397425e-01 0.027 0 0
Formation of the cornified envelope R-HSA-6809371 9.405181e-01 0.027 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.440414e-01 0.025 0 0
FGFR1 mutant receptor activation R-HSA-1839124 9.440414e-01 0.025 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.440414e-01 0.025 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.440414e-01 0.025 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.446613e-01 0.025 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.453574e-01 0.024 0 0
Signaling by NOTCH3 R-HSA-9012852 9.463715e-01 0.024 0 0
Signaling by NOTCH1 R-HSA-1980143 9.468997e-01 0.024 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.479825e-01 0.023 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.480338e-01 0.023 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.480338e-01 0.023 0 0
Ion homeostasis R-HSA-5578775 9.495495e-01 0.022 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.496955e-01 0.022 0 0
eNOS activation R-HSA-203615 9.517416e-01 0.021 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.517416e-01 0.021 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.517416e-01 0.021 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.517416e-01 0.021 0 0
Hyaluronan metabolism R-HSA-2142845 9.517416e-01 0.021 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.517416e-01 0.021 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.517416e-01 0.021 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.517416e-01 0.021 0 0
Signal amplification R-HSA-392518 9.517416e-01 0.021 0 0
Synthesis of PA R-HSA-1483166 9.525474e-01 0.021 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.548801e-01 0.020 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.551793e-01 0.020 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.551850e-01 0.020 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.551850e-01 0.020 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.551850e-01 0.020 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.560213e-01 0.020 0 0
GPVI-mediated activation cascade R-HSA-114604 9.583829e-01 0.018 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.583829e-01 0.018 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.583829e-01 0.018 0 0
Calmodulin induced events R-HSA-111933 9.583829e-01 0.018 0 0
CaM pathway R-HSA-111997 9.583829e-01 0.018 0 0
tRNA Aminoacylation R-HSA-379724 9.605526e-01 0.017 0 0
Voltage gated Potassium channels R-HSA-1296072 9.613529e-01 0.017 0 0
Degradation of AXIN R-HSA-4641257 9.613529e-01 0.017 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.613529e-01 0.017 0 0
Cleavage of the damaged purine R-HSA-110331 9.613529e-01 0.017 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 9.613529e-01 0.017 0 0
Metabolism of folate and pterines R-HSA-196757 9.613529e-01 0.017 0 0
Depurination R-HSA-73927 9.641110e-01 0.016 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.641110e-01 0.016 0 0
Signaling by PDGF R-HSA-186797 9.651515e-01 0.015 0 0
Adaptive Immune System R-HSA-1280218 9.658427e-01 0.015 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.666724e-01 0.015 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.666724e-01 0.015 0 0
RAS processing R-HSA-9648002 9.666724e-01 0.015 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.672531e-01 0.014 0 0
Glycogen metabolism R-HSA-8982491 9.690512e-01 0.014 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.690512e-01 0.014 0 0
Ion transport by P-type ATPases R-HSA-936837 9.692324e-01 0.014 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.695914e-01 0.013 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.705559e-01 0.013 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.706180e-01 0.013 0 0
PPARA activates gene expression R-HSA-1989781 9.710905e-01 0.013 0 0
Cellular response to hypoxia R-HSA-1234174 9.710962e-01 0.013 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.712603e-01 0.013 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.712603e-01 0.013 0 0
Maturation of spike protein R-HSA-9694548 9.712603e-01 0.013 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.733119e-01 0.012 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.733119e-01 0.012 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.733119e-01 0.012 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.733119e-01 0.012 0 0
Translation of Structural Proteins R-HSA-9683701 9.733119e-01 0.012 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.733195e-01 0.012 0 0
Phospholipid metabolism R-HSA-1483257 9.733933e-01 0.012 0 0
Platelet homeostasis R-HSA-418346 9.744084e-01 0.011 0 0
Parasitic Infection Pathways R-HSA-9824443 9.759284e-01 0.011 0 0
Leishmania infection R-HSA-9658195 9.759284e-01 0.011 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.769864e-01 0.010 0 0
Proteasome assembly R-HSA-9907900 9.786295e-01 0.009 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.786295e-01 0.009 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.786295e-01 0.009 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.788948e-01 0.009 0 0
Cellular response to chemical stress R-HSA-9711123 9.792237e-01 0.009 0 0
Hemostasis R-HSA-109582 9.800900e-01 0.009 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.801554e-01 0.009 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.801554e-01 0.009 0 0
Somitogenesis R-HSA-9824272 9.801554e-01 0.009 0 0
Hedgehog 'on' state R-HSA-5632684 9.801888e-01 0.009 0 0
Metabolism of cofactors R-HSA-8978934 9.801888e-01 0.009 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.804918e-01 0.009 0 0
Selenoamino acid metabolism R-HSA-2408522 9.805231e-01 0.009 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.814058e-01 0.008 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.815724e-01 0.008 0 0
Transmission across Chemical Synapses R-HSA-112315 9.816765e-01 0.008 0 0
Synthesis of PC R-HSA-1483191 9.828883e-01 0.007 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.835743e-01 0.007 0 0
Signaling by NOTCH4 R-HSA-9013694 9.836258e-01 0.007 0 0
Gluconeogenesis R-HSA-70263 9.841104e-01 0.007 0 0
Disease R-HSA-1643685 9.852078e-01 0.006 1 0
Chemokine receptors bind chemokines R-HSA-380108 9.852452e-01 0.006 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.853469e-01 0.006 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.856793e-01 0.006 0 0
Interferon alpha/beta signaling R-HSA-909733 9.856793e-01 0.006 0 0
Ion channel transport R-HSA-983712 9.858354e-01 0.006 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.862990e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9694635 9.864804e-01 0.006 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.869660e-01 0.006 0 0
Complex IV assembly R-HSA-9864848 9.872776e-01 0.006 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.872776e-01 0.006 0 0
The phototransduction cascade R-HSA-2514856 9.872776e-01 0.006 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.875996e-01 0.005 0 0
Muscle contraction R-HSA-397014 9.887420e-01 0.005 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.888481e-01 0.005 0 0
Signaling by Hedgehog R-HSA-5358351 9.891110e-01 0.005 0 0
Amyloid fiber formation R-HSA-977225 9.895435e-01 0.005 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.898140e-01 0.004 0 0
G alpha (z) signalling events R-HSA-418597 9.905417e-01 0.004 0 0
Opioid Signalling R-HSA-111885 9.908232e-01 0.004 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.912175e-01 0.004 0 0
Dectin-2 family R-HSA-5621480 9.918450e-01 0.004 0 0
Peroxisomal protein import R-HSA-9033241 9.929689e-01 0.003 0 0
Regulation of beta-cell development R-HSA-186712 9.929689e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.934714e-01 0.003 0 0
Metabolism of polyamines R-HSA-351202 9.934714e-01 0.003 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.934714e-01 0.003 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.934714e-01 0.003 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.934714e-01 0.003 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.934714e-01 0.003 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.934714e-01 0.003 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.939380e-01 0.003 0 0
ER-Phagosome pathway R-HSA-1236974 9.941672e-01 0.003 0 0
Mitochondrial protein import R-HSA-1268020 9.943713e-01 0.002 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.947736e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.949511e-01 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.955089e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.955104e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.957956e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.958162e-01 0.002 0 0
Metabolism of steroid hormones R-HSA-196071 9.961154e-01 0.002 0 0
Integration of energy metabolism R-HSA-163685 9.961903e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.962840e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.966266e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.967688e-01 0.001 0 0
Neddylation R-HSA-8951664 9.968690e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.970497e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.971686e-01 0.001 0 0
Purine catabolism R-HSA-74259 9.973193e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.973499e-01 0.001 0 0
Translation R-HSA-72766 9.973901e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.974237e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.975111e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.975197e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.976891e-01 0.001 0 0
Neuronal System R-HSA-112316 9.977233e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.978544e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.982827e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.982827e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.982827e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.982827e-01 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.986374e-01 0.001 0 0
Protein localization R-HSA-9609507 9.986470e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.988081e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.988153e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.988853e-01 0.000 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.990958e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.991197e-01 0.000 0 0
Keratinization R-HSA-6805567 9.992032e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.992551e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.993460e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.993491e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.994831e-01 0.000 0 0
Immune System R-HSA-168256 9.994834e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.995032e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.995091e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.995331e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.995604e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.996391e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.996693e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.996887e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.996890e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.997303e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.997802e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997855e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998152e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998726e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998854e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999816e-01 0.000 0 0
Neutrophil degranulation R-HSA-6798695 9.999876e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999879e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999893e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999899e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999902e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999902e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999927e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999931e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999952e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999954e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999962e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999969e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999996e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999998e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999999e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways