CK1A

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O00257 T437 SIGNOR|PSP CBX4 tHGEREPCKKRLTARsIstPtCLGGsPAAERPADLPPAAAL
O00571 S71 Sugiyama DDX3X DBX DDX3 GFyDKDSSGWsssKDKDAyssFGsRsDsRGKssFFsDRGsG
O14503 S243 SIGNOR|PSP BHLHE40 BHLHB2 DEC1 SHARP2 STRA13 IQRTFAHSSGEQSGSDTDTDsGYGGESEKGDLRSEQPCFKS
O15151 S289 SIGNOR|EPSD|PSP MDM4 MDMX KVSDKKVIEVGKNDDLEDSKsLSDDTDVEVTSEDEWQCTEC
O15169 S469 SIGNOR AXIN1 AXIN PRCVDMGCAGLRDAHEENPEsILDEHVQRVLRtPGRQsPGP
O15169 S75 SIGNOR AXIN1 AXIN ETSTATPRRSDLDLGYEPEGsAsPtPPYLKWAESLHSLLDD
O15169 S77 SIGNOR AXIN1 AXIN STATPRRSDLDLGYEPEGsAsPtPPYLKWAESLHSLLDDQD
O15523 S71 Sugiyama DDX3Y DBY GFHDKDSSGWSCSKDKDAyssFGsRDSRGKPGYFSERGSGS
O43524 S318 SIGNOR FOXO3 FKHRL1 FOXO3A RssDELDAWTDFRsRTNsNAsTVsGRLSPIMAsTELDEVQD
O43524 S321 SIGNOR FOXO3 FKHRL1 FOXO3A DELDAWTDFRsRTNsNAsTVsGRLSPIMAsTELDEVQDDDA
O43719 S600 Sugiyama HTATSF1 EKELHENVLDKELEENDsENsEFEDDGsEKVLDEEGsEREF
O43719 S607 Sugiyama HTATSF1 VLDKELEENDsENsEFEDDGsEKVLDEEGsEREFDEDsDEK
O43852 S261 Sugiyama CALU RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O43865 S77 SIGNOR AHCYL1 DCAL IRBIT XPVKONA KTGRRSLSRsIsQSsTDsySsAASYTDssDDEVSPREKQQT
O60260 S101 ELM|EPSD|PSP PRKN PARK2 NATGGDDPRNAAGGCEREPQsLTRVDLsssVLPGDSVGLAV
O60260 S378 ELM|EPSD|PSP PRKN PARK2 LGCGFAFCRECKEAYHEGECsAVFEASGTTTQAYRVDERAA
O60341 S687 EPSD|PSP KDM1A AOF2 KDM1 KIAA0601 LSD1 DRVFWDPSVNLFGHVGsTTAsRGELFLFWNLYKAPILLALV
O60346 S1359 SIGNOR|EPSD|PSP PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP TRILGYTFLHPSVVPRPHVQsVLLtPQDEFFILGSKGLWDs
O60346 S1379 EPSD|PSP PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP sVLLtPQDEFFILGSKGLWDsLsVEEAVEAVRNVPDALAAA
O60346 S1381 EPSD|PSP PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP LLtPQDEFFILGSKGLWDsLsVEEAVEAVRNVPDALAAAKK
O60346 T1363 SIGNOR|EPSD|PSP PHLPP1 KIAA0606 PHLPP PLEKHE1 SCOP GYTFLHPSVVPRPHVQsVLLtPQDEFFILGSKGLWDsLsVE
O60716 S268 PSP CTNND1 KIAA0384 yRAPsRQDVyGPQPQVRVGGssVDLHRFHPEPyGLEDDQRs
O60716 S269 SIGNOR|PSP CTNND1 KIAA0384 RAPsRQDVyGPQPQVRVGGssVDLHRFHPEPyGLEDDQRsM
O60841 S113 Sugiyama EIF5B IF2 KIAA0741 sKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTAKPKVEM
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O75581 S1490 PSP LRP6 SSSSssTKGtYFPAILNPPPsPAtERsHYTMEFGYSsNsPs
O75581 S1607 PSP LRP6 CPPsPYTERSYSHHLYPPPPsPCTDss______________
O75581 T1493 SIGNOR|EPSD|PSP LRP6 SssTKGtYFPAILNPPPsPAtERsHYTMEFGYSsNsPsTHR
O75581 T1572 PSP LRP6 TAKGYTSDLNyDSEPVPPPPtPRSQYLSAEENyESCPPsPY
O94916 S158 EPSD|PSP NFAT5 KIAA0827 TONEBP RHTVLyIsPPPEDLLDNsRMsCQDEGCGLESEQSCSMWMED
O95218 S153 Sugiyama ZRANB2 ZIS ZNF265 KYRGKAVGPAsILKEVEDKEsEGEEEDEDEDLsKyKLDEDE
O95218 S165 Sugiyama ZRANB2 ZIS ZNF265 LKEVEDKEsEGEEEDEDEDLsKyKLDEDEDEDDADLsKyNL
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P01106 S267 SIGNOR|PSP MYC BHLHE39 QGSPEPLVLHEEtPPTtssDsEEEQEDEEEIDVVSVEKRQA
P01106 S82 PSP MYC BHLHE39 EDIWKKFELLPtPPLsPsRRsGLCsPSyVAVTPFsLRGDND
P02730 S303 ELM|EPSD|PSP SLC4A1 AE1 DI EPB3 RAAATLMSERVFRIDAYMAQsRGELLHSLEGFLDCSLVLPP
P02730 T42 ELM|EPSD|PSP SLC4A1 AE1 DI EPB3 EDPDIPEsQMEEPAAHDtEAtAtDyHttsHPGtHKVYVELQ
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04637 S20 SIGNOR|EPSD|PSP TP53 P53 _MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM
P04637 S37 PSP TP53 P53 EtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQWFtED
P04637 S6 iPTMNet TP53 P53 _______________MEEPQsDPsVEPPLsQEtFsDLWKLL
P04637 S9 iPTMNet TP53 P53 ____________MEEPQsDPsVEPPLsQEtFsDLWKLLPEN
P04637 T18 ELM|EPSD|PSP TP53 P53 ___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07355 Y188 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D RKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVKRKGT
P07900 S263 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900 S726 PSP HSP90AA1 HSP90A HSPC1 HSPCA DDtsAAVtEEMPPLEGDDDtsRMEEVD______________
P07900 T725 PSP HSP90AA1 HSP90A HSPC1 HSPCA ADDtsAAVtEEMPPLEGDDDtsRMEEVD_____________
P07910 S253 SIGNOR|ELM|iPTMNet|EPSD|PSP HNRNPC HNRPC sEEEQssssVKKDETNVKMEsEGGADDsAEEGDLLDDDDNE
P07910 S260 SIGNOR|ELM|EPSD|PSP HNRNPC HNRPC ssVKKDETNVKMEsEGGADDsAEEGDLLDDDDNEDRGDDQL
P07910 S299 SIGNOR|ELM|EPSD|PSP HNRNPC HNRPC QLELIKDDEKEAEEGEDDRDsANGEDDs_____________
P08235 S936 PSP NR3C2 MCR MLR QSWQRFYQLTKLLDSMHDLVsDLLEFCFYTFRESHALKVEF
P08235 T800 PSP NR3C2 MCR MLR VVKWAKVLPGFKNLPLEDQItLIQYSWMCLSSFALSWRSYK
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 S718 PSP HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EEPNAAVPDEIPPLEGDEDAsRMEEVD______________
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0DMV8 T636 PSP HSPA1A HSP72 HSPA1 HSX70 GPGPGGFGAQGPKGGsGsGPtIEEVD_______________
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11308 S37 PSP ERG SLFECAYGTPHLAKTEMTASsssDYGQTsKMSPRVPQQDWL
P11308 S38 SIGNOR|PSP ERG LFECAYGTPHLAKTEMTASsssDYGQTsKMSPRVPQQDWLS
P11308 S39 SIGNOR|PSP ERG FECAYGTPHLAKTEMTASsssDYGQTsKMSPRVPQQDWLSQ
P11308 S45 EPSD ERG TPHLAKTEMTASsssDYGQTsKMSPRVPQQDWLSQPPARVT
P12830 S844 SIGNOR|EPSD|PSP CDH1 CDHE UVO APPYDSLLVFDYEGsGsEAAsLSsLNssEsDKDQDYDYLNE
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P16220 S100 SIGNOR|PSP CREB1 SPQVQTVQISTIAEsEDsQEsVDsVTDsQKRREILsRRPsY
P16220 S142 PSP CREB1 KILNDLssDAPGVPRIEEEKsEEETSAPAITTVTVPTPIYQ
P16220 S94 SIGNOR|PSP CREB1 QPSVIQSPQVQTVQISTIAEsEDsQEsVDsVTDsQKRREIL
P16220 S97 SIGNOR|PSP CREB1 VIQSPQVQTVQISTIAEsEDsQEsVDsVTDsQKRREILsRR
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P17181 S535 EPSD|PSP IFNAR1 IFNAR EETNQTDEDHKKySSQTsQDsGNysNEDESESKTSEELQQD
P17302 S325 PSP GJA1 GJAL AsEQNWANysAEQNRMGQAGstIsNsHAQPFDFPDDNQNsK
P17302 S328 PSP GJA1 GJAL QNWANysAEQNRMGQAGstIsNsHAQPFDFPDDNQNsKKLA
P17302 S330 PSP GJA1 GJAL WANysAEQNRMGQAGstIsNsHAQPFDFPDDNQNsKKLAAG
P17931 S12 SIGNOR|ELM|iPTMNet|EPSD|PSP LGALS3 MAC2 _________MADNFsLHDALsGSGNPNPQGWPGAWGNQPAG
P17931 S6 SIGNOR|ELM|iPTMNet|EPSD|PSP LGALS3 MAC2 _______________MADNFsLHDALsGSGNPNPQGWPGAW
P18846 S36 EPSD|PSP ATF1 PGSAVQGAHISHIAQQVSSLsEsEEsQDsSDsIGssQKAHG
P18846 S41 EPSD|PSP ATF1 QGAHISHIAQQVSSLsEsEEsQDsSDsIGssQKAHGILARR
P18846 S47 EPSD|PSP ATF1 HIAQQVSSLsEsEEsQDsSDsIGssQKAHGILARRPsYRKI
P18846 S50 EPSD|PSP ATF1 QQVSSLsEsEEsQDsSDsIGssQKAHGILARRPsYRKILKD
P18846 S51 EPSD|PSP ATF1 QVSSLsEsEEsQDsSDsIGssQKAHGILARRPsYRKILKDL
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P23396 S35 Sugiyama RPS3 OK/SW-cl.26 GIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATRT
P23588 S597 Sugiyama EIF4B KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P25054 S1279 ELM APC DP2.5 IQTYCVEDTPICFSRCSSLSsLSSAEDEIGCNQTTQEADSA
P25054 S1392 ELM APC DP2.5 PPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEPCSG
P25054 S1504 EPSD|PSP APC DP2.5 DADTLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELRI
P25054 S1505 EPSD|PSP APC DP2.5 ADTLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELRIM
P25054 S1507 EPSD|PSP APC DP2.5 TLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELRIMPP
P25054 S1510 EPSD|PSP APC DP2.5 HFATESTPDGFsCsssLsALsLDEPFIQKDVELRIMPPVQE
P27348 S232 SIGNOR|ELM|iPTMNet|EPSD|PSP YWHAQ KDstLIMQLLRDNLTLWtsDsAGEECDAAEGAEN_______
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27348 Y48 Sugiyama YWHAQ AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30304 S79 SIGNOR|EPSD|PSP CDC25A yEQPLEVKNNSNLQRMGsSEstDsGFCLDsPGPLDSKENLE
P30304 S82 SIGNOR|EPSD|PSP CDC25A PLEVKNNSNLQRMGsSEstDsGFCLDsPGPLDSKENLENPM
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31946 Y50 Sugiyama YWHAB AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31947 Y48 Sugiyama SFN HME1 GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35222 S45 SIGNOR|ELM|iPTMNet|EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 WQQQsyLDsGIHsGATtTAPsLsGKGNPEEEDVDTsQVLyE
P35398 S100 PSP RORA NR1F1 RZRA SSGIHYGVITCEGCKGFFRRsQQSNATYSCPRQKNCLIDRT
P37840 S129 SIGNOR|ELM|EPSD|PSP SNCA NACP PARK1 QEGILEDMPVDPDNEAyEMPsEEGyQDyEPEA_________
P37840 S87 SIGNOR|EPSD|PSP SNCA NACP PARK1 GGAVVTGVTAVAQKTVEGAGsIAAATGFVKKDQLGKNEEGA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P40337 S72 EPSD|PSP VHL EEMEAGRPRPVLRSVNsREPsQVIFCNRsPRVVLPVWLNFD
P42892 S34 EPSD|PSP ECE1 SALGMSTYKRAtLDEEDLVDsLsEGDAYPNGLQVNFHsPRS
P42892 S36 EPSD|PSP ECE1 LGMSTYKRAtLDEEDLVDsLsEGDAYPNGLQVNFHsPRSGQ
P46783 T148 Sugiyama RPS10 RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P47712 S454 Sugiyama PLA2G4A CPLA2 PLA2G4 ssDsDDEsHEPKGtENEDAGsDyQsDNQASWIHRMIMALVS
P48729 Y59 Sugiyama CSNK1A1 NGEEVAVKLESQKARHPQLLyESKLYKILQGGVGIPHIRWY
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P49674 S323 ELM CSNK1E DVDRERREHEREERMGQLRGsAtRALPPGPPtGAtANRLRs
P49674 S368 ELM CSNK1E VASTPAsRIQPAGNtsPRAIsRVDRERKVSMRLHRGAPANV
P49674 S405 ELM CSNK1E PANVsssDLTGRQEVSRIPAsQtsVPFDHLGK_________
P49674 S408 ELM CSNK1E VsssDLTGRQEVSRIPAsQtsVPFDHLGK____________
P49674 T325 ELM CSNK1E DRERREHEREERMGQLRGsAtRALPPGPPtGAtANRLRsAA
P49674 T334 ELM CSNK1E EERMGQLRGsAtRALPPGPPtGAtANRLRsAAEPVASTPAs
P49674 T337 ELM CSNK1E MGQLRGsAtRALPPGPPtGAtANRLRsAAEPVASTPAsRIQ
P49674 T407 ELM CSNK1E NVsssDLTGRQEVSRIPAsQtsVPFDHLGK___________
P49810 S19 SIGNOR|ELM|iPTMNet PSEN2 AD4 PS2 PSNL2 STM2 __MLTFMAsDsEEEVCDERtsLMsAEsPtPRSCQEGRQGPE
P49810 S7 SIGNOR|ELM|iPTMNet PSEN2 AD4 PS2 PSNL2 STM2 ______________MLTFMAsDsEEEVCDERtsLMsAEsPt
P49810 S9 SIGNOR|ELM|iPTMNet PSEN2 AD4 PS2 PSNL2 STM2 ____________MLTFMAsDsEEEVCDERtsLMsAEsPtPR
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51532 S699 Sugiyama SMARCA4 BAF190A BRG1 SNF2B SNF2L4 PPTLPVEEKKKIPDPDsDDVsEVDARHIIENAKQDVDDEyG
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S19 Sugiyama SUB1 PC4 RPO2TC1 __MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPVKK
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55316 S19 SIGNOR|EPSD|PSP FOXG1 FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FOXG1A FOXG1B FOXG1C __MLDMGDRKEVKMIPKSSFsINSLVPEAVQNDNHHASHGH
P55854 S27 Sugiyama SUMO3 SMT3A SMT3H1 KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P55957 S64 SIGNOR|ELM|iPTMNet|PSP BID LPVLAPQWEGyDELQtDGNRssHsRLGRIEADsEsQEDIIR
P55957 S67 PSP BID LAPQWEGyDELQtDGNRssHsRLGRIEADsEsQEDIIRNIA
P55957 T59 SIGNOR|ELM|iPTMNet BID ALGHELPVLAPQWEGyDELQtDGNRssHsRLGRIEADsEsQ
P56537 S174 EPSD|PSP EIF6 EIF3A ITGB4BP OK/SW-cl.27 FSNQGGLVHPKtsIEDQDELssLLQVPLVAGTVNRGSEVIA
P56537 S175 EPSD|PSP EIF6 EIF3A ITGB4BP OK/SW-cl.27 SNQGGLVHPKtsIEDQDELssLLQVPLVAGTVNRGSEVIAA
P56817 S498 ELM|EPSD|PSP BACE1 BACE KIAA1149 CQWRCLRCLRQQHDDFADDIsLLK_________________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61247 S237 Sugiyama RPS3A FTE1 MFTL MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61916 S29 Sugiyama NPC2 HE1 LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61956 S28 Sugiyama SUMO2 SMT3B SMT3H2 EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 Y49 Sugiyama YWHAG NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62258 Y49 Sugiyama YWHAE KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62745 S185 SIGNOR|EPSD|PSP RHOB ARH6 ARHB EGVREVFETATRAALQKRYGsQNGCINCCKVL_________
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104 T232 SIGNOR|ELM|iPTMNet|EPSD|PSP YWHAZ KDstLIMQLLRDNLtLWtsDtQGDEAEAGEGGEN_______
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63104 Y48 Sugiyama YWHAZ sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S174 Sugiyama YBX1 NSEP1 YB1 PPRNyQQNyQNsEsGEKNEGsEsAPEGQAQQRRPyRRRRFP
P67809 S176 EPSD|PSP YBX1 NSEP1 YB1 RNyQQNyQNsEsGEKNEGsEsAPEGQAQQRRPyRRRRFPPy
P67936 T237 Sugiyama TPM4 IDDLEEKLAQAKEENVGLHQtLDQtLNELNCI_________
P67936 T241 Sugiyama TPM4 EEKLAQAKEENVGLHQtLDQtLNELNCI_____________
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P78362 S497 SIGNOR|PSP SRPK2 LTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLLVNPLD
P98177 S265 SIGNOR|EPSD|PSP FOXO4 AFX AFX1 MLLT7 RNREEADMWTTFRPRSSsNAsSVsTRLSPLRPESEVLAEEI
P98177 S268 SIGNOR|EPSD|PSP FOXO4 AFX AFX1 MLLT7 EEADMWTTFRPRSSsNAsSVsTRLSPLRPESEVLAEEIPAS
Q00535 S159 SIGNOR|ELM|EPSD|PSP CDK5 CDKN5 PSSALRE ELKLADFGLARAFGIPVRCYsAEVVTLWYRPPDVLFGAKLY
Q00613 S375 Sugiyama HSF1 HSTF1 TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q04206 S316 SIGNOR|EPSD|PSP RELA NFKB3 HRIEEKRKRtYEtFKsIMKKsPFSGPTDPRPPPRRIAVPSR
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q04917 Y49 Sugiyama YWHAH YWHA1 AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q05940 S511 SIGNOR|ELM|iPTMNet SLC18A2 SVMT VMAT2 KTKMYTQNNIQSYPIGEDEEsEsD_________________
Q05940 S513 SIGNOR|ELM SLC18A2 SVMT VMAT2 KMYTQNNIQSYPIGEDEEsEsD___________________
Q12778 S322 ELM|EPSD|PSP FOXO1 FKHR FOXO1A HsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGD
Q12778 S325 ELM|EPSD|PSP FOXO1 FKHR FOXO1A DDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGDVHS
Q12968 S207 SIGNOR|ELM|iPTMNet|EPSD|PSP NFATC3 NFAT4 HIYDDVDSELNEAAARFtLGsPLtsPGGsPGGCPGEETWHQ
Q12968 S211 SIGNOR|ELM|iPTMNet|EPSD|PSP NFATC3 NFAT4 DVDSELNEAAARFtLGsPLtsPGGsPGGCPGEETWHQQYGL
Q12968 S215 SIGNOR|ELM|iPTMNet|EPSD|PSP NFATC3 NFAT4 ELNEAAARFtLGsPLtsPGGsPGGCPGEETWHQQYGLGHSL
Q12968 T204 SIGNOR|ELM|iPTMNet|EPSD|PSP NFATC3 NFAT4 sLsHIYDDVDSELNEAAARFtLGsPLtsPGGsPGGCPGEET
Q12968 T210 SIGNOR|ELM|iPTMNet|EPSD|PSP NFATC3 NFAT4 DDVDSELNEAAARFtLGsPLtsPGGsPGGCPGEETWHQQYG
Q13009 S329 SIGNOR|PSP TIAM1 SNsMQGRRAKttQDVNAGEGsEFADsGIEGAtTDTDLLSRR
Q13144 S466 SIGNOR|iPTMNet EIF2B5 EIF2BE GSVISLHPPDAEEDEDDGEFsDDsGADQEKDKVKMKGYNPA
Q13144 S469 SIGNOR|iPTMNet EIF2B5 EIF2BE ISLHPPDAEEDEDDGEFsDDsGADQEKDKVKMKGYNPAEVG
Q13144 S51 iPTMNet EIF2B5 EIF2BE GARGAEEEPPPPLQAVLVADsFDRRFFPISKDQPRVLLPLA
Q13148 S183 EPSD|PSP TARDBP TDP43 SQRHMIDGRWCDCKLPNSKQsQDEPLRSRKVFVGRCTEDMT
Q13148 S2 EPSD|PSP TARDBP TDP43 ___________________MsEyIRVtEDENDEPIEIPSED
Q13148 S242 EPSD|PSP TARDBP TDP43 IPKPFRAFAFVTFADDQIAQsLCGEDLIIKGIsVHISNAEP
Q13148 S254 EPSD|PSP TARDBP TDP43 FADDQIAQsLCGEDLIIKGIsVHISNAEPKHNSNRQLERsG
Q13148 S273 EPSD|PSP TARDBP TDP43 IsVHISNAEPKHNSNRQLERsGRFGGNPGGFGNQGGFGNsR
Q13148 S292 EPSD|PSP TARDBP TDP43 RsGRFGGNPGGFGNQGGFGNsRGGGAGLGNNQGsNMGGGMN
Q13148 S305 EPSD|PSP TARDBP TDP43 NQGGFGNsRGGGAGLGNNQGsNMGGGMNFGAFsINPAMMAA
Q13148 S342 EPSD|PSP TARDBP TDP43 MMAAAQAALQSsWGMMGMLAsQQNQsGPsGNNQNQGNMQRE
Q13148 S347 EPSD|PSP TARDBP TDP43 QAALQSsWGMMGMLAsQQNQsGPsGNNQNQGNMQREPNQAF
Q13148 S350 EPSD|PSP TARDBP TDP43 LQSsWGMMGMLAsQQNQsGPsGNNQNQGNMQREPNQAFGsG
Q13148 S369 EPSD|PSP TARDBP TDP43 PsGNNQNQGNMQREPNQAFGsGNNSYsGsNsGAAIGWGsAs
Q13148 S375 EPSD|PSP TARDBP TDP43 NQGNMQREPNQAFGsGNNSYsGsNsGAAIGWGsAsNAGsGs
Q13148 S377 EPSD|PSP TARDBP TDP43 GNMQREPNQAFGsGNNSYsGsNsGAAIGWGsAsNAGsGsGF
Q13148 S379 EPSD|PSP TARDBP TDP43 MQREPNQAFGsGNNSYsGsNsGAAIGWGsAsNAGsGsGFNG
Q13148 S387 EPSD|PSP TARDBP TDP43 FGsGNNSYsGsNsGAAIGWGsAsNAGsGsGFNGGFGssMDs
Q13148 S389 EPSD|PSP TARDBP TDP43 sGNNSYsGsNsGAAIGWGsAsNAGsGsGFNGGFGssMDsKs
Q13148 S393 EPSD|PSP TARDBP TDP43 SYsGsNsGAAIGWGsAsNAGsGsGFNGGFGssMDsKssGWG
Q13148 S395 EPSD|PSP TARDBP TDP43 sGsNsGAAIGWGsAsNAGsGsGFNGGFGssMDsKssGWGM_
Q13148 S403 EPSD|PSP TARDBP TDP43 IGWGsAsNAGsGsGFNGGFGssMDsKssGWGM_________
Q13148 S404 EPSD|PSP TARDBP TDP43 GWGsAsNAGsGsGFNGGFGssMDsKssGWGM__________
Q13148 S407 EPSD|PSP TARDBP TDP43 sAsNAGsGsGFNGGFGssMDsKssGWGM_____________
Q13148 S409 EPSD|PSP TARDBP TDP43 sNAGsGsGFNGGFGssMDsKssGWGM_______________
Q13148 S410 EPSD|PSP TARDBP TDP43 NAGsGsGFNGGFGssMDsKssGWGM________________
Q13148 S91 EPSD|PSP TARDBP TDP43 LVYVVNYPKDNKRKMDEtDAssAVKVKRAVQKTSDLIVLGL
Q13148 S92 EPSD|PSP TARDBP TDP43 VYVVNYPKDNKRKMDEtDAssAVKVKRAVQKTSDLIVLGLP
Q13148 T116 EPSD|PSP TARDBP TDP43 VKRAVQKTSDLIVLGLPWKttEQDLKEYFSTFGEVLMVQVK
Q13148 T25 EPSD|PSP TARDBP TDP43 IRVtEDENDEPIEIPSEDDGtVLLSTVTAQFPGACGLRYRN
Q13148 T88 EPSD|PSP TARDBP TDP43 WGNLVYVVNYPKDNKRKMDEtDAssAVKVKRAVQKTSDLIV
Q13148 Y4 EPSD|PSP TARDBP TDP43 _________________MsEyIRVtEDENDEPIEIPSEDDG
Q13158 S194 SIGNOR|iPTMNet|EPSD|PSP FADD MORT1 GIG3 ADLVQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS______
Q13263 S784 Sugiyama TRIM28 KAP1 RNF96 TIF1B DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13315 S1270 SIGNOR ATM SCYKVLIPHLVIRSHFDEVKsIANQIQEDWKSLLTDCFPKI
Q13435 S317 Sugiyama SF3B2 SAP145 ETDARssLGQsAsEtEEDtVsVsKKEKNRKRRNRKKKKKPQ
Q13501 S349 SIGNOR|EPSD|PSP SQSTM1 ORCA OSIL DNCsGGDDDWtHLssKEVDPstGELQsLQMPEsEGPssLDP
Q15185 S118 Sugiyama PTGES3 P23 TEBP WLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGDEDVDL
Q6EEV6 S28 Sugiyama SUMO4 SMT3H4 EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6IE81 S18 SIGNOR|EPSD|PSP JADE1 KIAA1807 PHF17 ___MKRGRLPSSSEDSDDNGsLsTTWSQNSRSQHRRSSCSR
Q6IE81 S20 SIGNOR|EPSD|PSP JADE1 KIAA1807 PHF17 _MKRGRLPSSSEDSDDNGsLsTTWSQNSRSQHRRSSCSRHE
Q6UXH1 S295 Sugiyama CRELD2 UNQ185/PRO211 KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q7Z4V5 S181 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 ALKMsVSKRARKASSDLDQAsVsPSEEENSESSsESEKTsD
Q8ND56 S374 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A EDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEERRLNAE
Q8TB45 S263 EPSD|PSP DEPTOR DEPDC6 DsPFCLRKQSHDNRKstsFMsVsPsKEIKIVSAVRRssMss
Q8TB45 S286 SIGNOR|EPSD|PSP DEPTOR DEPDC6 PsKEIKIVSAVRRssMssCGssGyFsssPtLsssPPVLCNP
Q8TB45 S287 SIGNOR|EPSD|PSP DEPTOR DEPDC6 sKEIKIVSAVRRssMssCGssGyFsssPtLsssPPVLCNPK
Q8TB45 S291 SIGNOR|EPSD|PSP DEPTOR DEPDC6 KIVSAVRRssMssCGssGyFsssPtLsssPPVLCNPKSVLK
Q8TB45 T149 EPSD|PSP DEPTOR DEPDC6 EVKAFMRGQRLYEKLMsPENtLLQPREEEGVKYERTFMAsE
Q969R2 S762 PSP OSBP2 KIAA1664 ORP4 OSBPL4 AHYVLSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSA
Q969R2 S763 PSP OSBP2 KIAA1664 ORP4 OSBPL4 HYVLSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAK
Q969R2 S766 PSP OSBP2 KIAA1664 ORP4 OSBPL4 LSGSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAKLLW
Q969R2 S768 PSP OSBP2 KIAA1664 ORP4 OSBPL4 GSWDEQMECSKVMHssPssPsSDGKQKTVYQTLSAKLLWKK
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96P20 S806 PSP NLRP3 C1orf7 CIAS1 NALP3 PYPAF1 CCFDISLVLSSNQKLVELDLsDNALGDFGIRLLCVGLKHLL
Q96SB4 S334 Sugiyama SRPK1 ERPLKENPPNKMtQEKLEEsstIGQDQtLMERDTEGGAAEI
Q99733 S121 Sugiyama NAP1L4 NAP2 PLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKV
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BVS4 S332 Sugiyama RIOK2 RIO2 DDELLHPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsEN
Q9BVS4 S335 Sugiyama RIOK2 RIO2 LLHPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsENEsE
Q9BVS4 S337 Sugiyama RIOK2 RIO2 HPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsENEsERN
Q9BXL7 S615 EPSD|PSP CARD11 CARMA1 GFDALDLDDDSHERYSFGPSsIHSSSSSHQSEGLDAYDLEQ
Q9C0C2 S1174 Sugiyama TNKS1BP1 KIAA1741 TAB182 ttAGsVDWTDQLGLRNLEVssCVGsGGssEAREsAVGQMGW
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H1E3 S144 Sugiyama NUCKS1 NUCKS JC7 PFQEKDsGsDEDFLMEDDDDsDyGSsKKKNKKMVKKSKPER
Q9H6E5 S6 SIGNOR|EPSD|PSP TUT1 RBM21 _______________MAAVDsDVESLPRGGFRCCLCHVTTA
Q9HCN4 S338 Sugiyama GPN1 MBDIN RPAP4 XAB1 HUSSY-23 HPsDLILtRGTLDEEDEEADsDtDDIDHRVTEESHEEPAFQ
Q9NQ39 T159 Sugiyama RPS10P5 RPS10L RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NR28 S230 Sugiyama DIABLO SMAC EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NRF8 S568 SIGNOR|EPSD|PSP CTPS2 TGNLNAYLQQGCKLsssDRysDAsDDsFSEPRIAELEIS__
Q9P2Y5 S522 PSP UVRAG GHRKRAssENERLQyKtPPPsyNsALAQPVTTVPSMGETER
Q9UDY8 S573 PSP MALT1 MLT SLSEKRALTDPIQGTEYSAEsLVRNLQWAKAHELPESMCLK
Q9UGI0 S209 SIGNOR|PSP ZRANB1 TRABID EEASSIINEQDRARWRGSCSsGNSQRRSPPATKRDSEVKMD
Q9UGI0 T35 SIGNOR|PSP ZRANB1 TRABID YENWPSAIKCTMCRAQRPSGtIITEDPFKSGSSDVGRDWDP
Q9UKV8 S824 SIGNOR|PSP AGO2 EIF2C2 YYAHLVAFRARYHLVDKEHDsAEGsHtsGQsNGRDHQALAK
Q9UKV8 S828 SIGNOR|PSP AGO2 EIF2C2 LVAFRARYHLVDKEHDsAEGsHtsGQsNGRDHQALAKAVQV
Q9UKV8 S831 SIGNOR|PSP AGO2 EIF2C2 FRARYHLVDKEHDsAEGsHtsGQsNGRDHQALAKAVQVHQD
Q9UKV8 S834 SIGNOR|PSP AGO2 EIF2C2 RYHLVDKEHDsAEGsHtsGQsNGRDHQALAKAVQVHQDTLR
Q9UKV8 T830 SIGNOR|PSP AGO2 EIF2C2 AFRARYHLVDKEHDsAEGsHtsGQsNGRDHQALAKAVQVHQ
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2W7 S63 ELM|EPSD|PSP KCNIP3 CSEN DREAM KCHIP3 MRCCLVKWILSSTAPQGSDSsDSELELSTVRHQPEGLDQLQ
Q9Y4G8 S1244 SIGNOR|EPSD|PSP RAPGEF2 KIAA0313 NRAPGEP PDZGEF1 PstEELSQDQGDRASLDAADsGRGsWTSCssGsHDNIQTIQ
Q9Y4G8 S1248 SIGNOR|EPSD|PSP RAPGEF2 KIAA0313 NRAPGEP PDZGEF1 ELSQDQGDRASLDAADsGRGsWTSCssGsHDNIQTIQHQRS
Q9Y4L1 T969 Sugiyama HYOU1 GRP170 HSPH4 ORP150 EDAEPISEPEKVEtGsEPGDtEPLELGGPGAEPEQKEQSTG
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 3.851652e-10 9.414 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.495360e-07 6.603 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.010028e-05 4.996 0 0
Apoptotic execution phase R-HSA-75153 1.663522e-05 4.779 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.208032e-05 4.494 0 0
NRAGE signals death through JNK R-HSA-193648 3.100675e-05 4.509 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.009002e-05 4.300 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.009002e-05 4.300 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.201031e-05 4.208 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.201031e-05 4.208 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 9.498717e-05 4.022 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.697993e-05 4.061 0 0
G alpha (12/13) signalling events R-HSA-416482 9.746391e-05 4.011 0 0
Death Receptor Signaling R-HSA-73887 1.114196e-04 3.953 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.202824e-04 3.920 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.202824e-04 3.920 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.331720e-04 3.876 1 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.455499e-04 3.837 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.634697e-04 3.787 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.883809e-04 3.725 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.883809e-04 3.725 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.331761e-04 3.632 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.331761e-04 3.632 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.416083e-04 3.617 0 0
Signaling by Hippo R-HSA-2028269 2.681323e-04 3.572 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.826241e-04 3.549 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.826241e-04 3.549 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.906795e-04 3.537 0 0
Nuclear import of Rev protein R-HSA-180746 2.866568e-04 3.543 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.783990e-04 3.320 0 0
TGFBR3 expression R-HSA-9839394 5.748437e-04 3.240 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.898987e-04 3.161 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.690958e-04 3.175 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.335447e-04 3.079 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.088120e-04 3.092 0 0
Mitotic Anaphase R-HSA-68882 8.808068e-04 3.055 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.419907e-04 3.026 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 9.519811e-04 3.021 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 9.519811e-04 3.021 0 0
Nervous system development R-HSA-9675108 1.019676e-03 2.992 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.030188e-03 2.987 0 0
Signaling by EGFR R-HSA-177929 1.121100e-03 2.950 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.211722e-03 2.917 0 0
Repression of WNT target genes R-HSA-4641265 1.319050e-03 2.880 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.314908e-03 2.881 0 0
Mitotic Prometaphase R-HSA-68877 1.315238e-03 2.881 0 0
Axon guidance R-HSA-422475 1.402395e-03 2.853 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.444458e-03 2.840 0 0
M Phase R-HSA-68886 1.568553e-03 2.805 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.530905e-03 2.815 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.816288e-03 2.741 0 0
EGFR downregulation R-HSA-182971 1.927345e-03 2.715 0 0
Chromatin organization R-HSA-4839726 1.944512e-03 2.711 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.149147e-03 2.668 0 0
tRNA processing in the nucleus R-HSA-6784531 2.427370e-03 2.615 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.726120e-03 2.564 0 0
Nuclear RNA decay R-HSA-9930044 2.726120e-03 2.564 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.956913e-03 2.529 0 0
Cellular response to heat stress R-HSA-3371556 2.917039e-03 2.535 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.956913e-03 2.529 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.072919e-03 2.512 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.190365e-03 2.496 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.208184e-03 2.494 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.868661e-03 2.412 0 0
Signaling by TGFB family members R-HSA-9006936 3.888072e-03 2.410 0 0
Cellular Senescence R-HSA-2559583 4.093812e-03 2.388 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.222890e-03 2.374 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.222890e-03 2.374 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.391721e-03 2.357 0 0
Separation of Sister Chromatids R-HSA-2467813 5.066048e-03 2.295 0 0
Inositol phosphate metabolism R-HSA-1483249 5.603924e-03 2.252 0 0
Mitotic Prophase R-HSA-68875 5.738231e-03 2.241 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.873281e-03 2.231 0 0
Specification of primordial germ cells R-HSA-9827857 6.190478e-03 2.208 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.693292e-03 2.174 0 0
Cell-Cell communication R-HSA-1500931 6.713518e-03 2.173 0 0
Semaphorin interactions R-HSA-373755 7.161147e-03 2.145 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.170297e-03 2.144 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.183082e-03 2.144 0 0
Signaling by TGFBR3 R-HSA-9839373 7.431466e-03 2.129 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.608771e-03 2.119 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.608771e-03 2.119 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.682060e-03 2.061 0 0
Chromatin modifying enzymes R-HSA-3247509 8.562384e-03 2.067 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.700398e-03 2.060 0 0
Diseases of Telomere Maintenance R-HSA-9673013 9.723183e-03 2.012 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 9.723183e-03 2.012 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 9.723183e-03 2.012 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 9.723183e-03 2.012 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 9.723183e-03 2.012 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.982734e-03 2.047 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.982734e-03 2.047 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.018297e-02 1.992 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.073918e-02 1.969 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.112349e-02 1.954 0 0
Negative regulation of MET activity R-HSA-6807004 1.112349e-02 1.954 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.120370e-02 1.951 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.239046e-02 1.907 0 0
HIV Life Cycle R-HSA-162587 1.172013e-02 1.931 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.239046e-02 1.907 0 0
snRNP Assembly R-HSA-191859 1.188666e-02 1.925 0 0
Metabolism of non-coding RNA R-HSA-194441 1.188666e-02 1.925 0 0
MTOR signalling R-HSA-165159 1.273935e-02 1.895 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.384543e-02 1.859 0 0
DCC mediated attractive signaling R-HSA-418885 1.384543e-02 1.859 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.384543e-02 1.859 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.565381e-02 1.805 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.565381e-02 1.805 0 0
Membrane Trafficking R-HSA-199991 1.445529e-02 1.840 0 0
Cell junction organization R-HSA-446728 1.441553e-02 1.841 0 0
MAPK family signaling cascades R-HSA-5683057 1.529754e-02 1.815 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.565381e-02 1.805 0 0
Cell Cycle, Mitotic R-HSA-69278 1.493261e-02 1.826 0 0
Cell Cycle R-HSA-1640170 1.453009e-02 1.838 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.589291e-02 1.799 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.599537e-02 1.796 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.680943e-02 1.774 0 0
Signaling by FGFR in disease R-HSA-1226099 1.988879e-02 1.701 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.085223e-02 1.681 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.169547e-02 1.664 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.196488e-02 1.658 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.196488e-02 1.658 0 0
Deubiquitination R-HSA-5688426 2.254949e-02 1.647 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.270917e-02 1.644 0 0
Activation of RAC1 R-HSA-428540 2.554702e-02 1.593 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.554702e-02 1.593 1 0
Diseases of mitotic cell cycle R-HSA-9675126 2.354269e-02 1.628 0 0
Developmental Biology R-HSA-1266738 2.488829e-02 1.604 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.657374e-02 1.576 0 0
Long-term potentiation R-HSA-9620244 2.823888e-02 1.549 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.823888e-02 1.549 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.823888e-02 1.549 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.850394e-02 1.545 0 0
Host Interactions of HIV factors R-HSA-162909 2.878277e-02 1.541 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.907096e-02 1.537 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.929588e-02 1.533 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.986014e-02 1.525 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.994385e-02 1.524 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.994385e-02 1.524 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.321426e-02 1.479 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.145020e-02 1.502 1 1
Clathrin-mediated endocytosis R-HSA-8856828 3.156570e-02 1.501 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.438224e-02 1.464 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.075936e-02 1.512 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.145020e-02 1.502 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.534460e-02 1.452 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.534460e-02 1.452 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.534460e-02 1.452 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.534460e-02 1.452 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.534460e-02 1.452 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.534460e-02 1.452 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.534460e-02 1.452 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.534460e-02 1.452 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.534460e-02 1.452 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.534460e-02 1.452 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.534460e-02 1.452 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.534460e-02 1.452 0 0
Regulation of TP53 Expression R-HSA-6804754 3.534460e-02 1.452 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.652747e-02 1.437 0 0
Oncogene Induced Senescence R-HSA-2559585 3.722943e-02 1.429 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.812013e-02 1.419 0 0
SOS-mediated signalling R-HSA-112412 3.812013e-02 1.419 0 0
Type I hemidesmosome assembly R-HSA-446107 4.813980e-02 1.317 0 0
Formation of annular gap junctions R-HSA-196025 4.813980e-02 1.317 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.480565e-02 1.349 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.614352e-02 1.336 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.573242e-02 1.340 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.043773e-02 1.297 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 4.423793e-02 1.354 0 0
Regulation of KIT signaling R-HSA-1433559 4.480565e-02 1.349 0 0
Formation of definitive endoderm R-HSA-9823730 3.851949e-02 1.414 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.570377e-02 1.340 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.352852e-02 1.361 0 0
RUNX2 regulates bone development R-HSA-8941326 4.132565e-02 1.384 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.614352e-02 1.336 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.084038e-02 1.389 0 0
Apoptosis R-HSA-109581 4.677183e-02 1.330 0 0
TNF signaling R-HSA-75893 4.914818e-02 1.308 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.262142e-02 1.279 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.262142e-02 1.279 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 5.267070e-02 1.278 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.267070e-02 1.278 0 0
MET interacts with TNS proteins R-HSA-8875513 5.267070e-02 1.278 0 0
Post NMDA receptor activation events R-HSA-438064 5.411459e-02 1.267 0 0
Signaling by ALK R-HSA-201556 5.532306e-02 1.257 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.561700e-02 1.255 0 0
NGF-stimulated transcription R-HSA-9031628 5.699547e-02 1.244 0 0
mTORC1-mediated signalling R-HSA-166208 5.712119e-02 1.243 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.712119e-02 1.243 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 7.060221e-02 1.151 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 7.060221e-02 1.151 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.931156e-02 1.227 0 0
Gap junction degradation R-HSA-190873 5.931156e-02 1.227 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.057071e-02 1.218 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.179210e-02 1.209 0 0
Signaling by WNT R-HSA-195721 7.013556e-02 1.154 1 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.981317e-02 1.156 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.385644e-02 1.195 0 0
HIV Infection R-HSA-162906 6.953141e-02 1.158 0 0
HATs acetylate histones R-HSA-3214847 6.575242e-02 1.182 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.611320e-02 1.180 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.611320e-02 1.180 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.711250e-02 1.173 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.318282e-02 1.199 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.931156e-02 1.227 0 0
MAP kinase activation R-HSA-450294 7.110943e-02 1.148 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.981317e-02 1.156 0 0
Signaling by MET R-HSA-6806834 6.318282e-02 1.199 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.959496e-02 1.225 0 0
Signaling by ALK in cancer R-HSA-9700206 5.959496e-02 1.225 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.031786e-02 1.153 0 0
Gene Silencing by RNA R-HSA-211000 5.959496e-02 1.225 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.112935e-02 1.214 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.158031e-02 1.145 0 0
Regulation of CDH11 function R-HSA-9762292 7.158031e-02 1.145 0 0
Signal attenuation R-HSA-74749 7.158031e-02 1.145 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.158031e-02 1.145 0 0
PTEN Regulation R-HSA-6807070 7.192892e-02 1.143 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.195152e-02 1.143 0 0
Regulation of gap junction activity R-HSA-191650 7.235885e-02 1.141 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 7.235885e-02 1.141 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 7.235885e-02 1.141 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 7.235885e-02 1.141 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.320639e-02 1.135 1 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.612980e-02 1.118 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.612980e-02 1.118 0 0
EPH-Ephrin signaling R-HSA-2682334 7.673880e-02 1.115 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.714619e-02 1.113 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.765688e-02 1.110 0 0
IRS activation R-HSA-74713 9.398973e-02 1.027 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 9.398973e-02 1.027 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 9.398973e-02 1.027 0 0
G2 Phase R-HSA-68911 9.398973e-02 1.027 0 0
Signaling by APC mutants R-HSA-4839744 8.488191e-02 1.071 1 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 8.488191e-02 1.071 1 1
APC truncation mutants have impaired AXIN binding R-HSA-5467337 8.488191e-02 1.071 1 1
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 8.488191e-02 1.071 1 1
Signaling by GSK3beta mutants R-HSA-5339716 9.914551e-02 1.004 1 1
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.066756e-02 1.043 0 0
Ephrin signaling R-HSA-3928664 9.066756e-02 1.043 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.384871e-02 1.077 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.343902e-02 1.079 0 0
Nucleotide Excision Repair R-HSA-5696398 9.420003e-02 1.026 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.492374e-02 1.071 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.864829e-02 1.052 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 9.769673e-02 1.010 1 1
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.005794e-02 1.097 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 9.398973e-02 1.027 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.743450e-02 1.058 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.769673e-02 1.010 0 0
Signaling by ROBO receptors R-HSA-376176 9.896407e-02 1.005 0 0
Myogenesis R-HSA-525793 8.864829e-02 1.052 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.451513e-02 1.073 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 9.914551e-02 1.004 0 0
Signaling by AXIN mutants R-HSA-4839735 9.914551e-02 1.004 1 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.492374e-02 1.071 0 0
TBC/RABGAPs R-HSA-8854214 8.451513e-02 1.073 0 0
NrCAM interactions R-HSA-447038 9.398973e-02 1.027 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.488191e-02 1.071 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.017843e-01 0.992 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.046265e-01 0.980 0 0
Rab regulation of trafficking R-HSA-9007101 1.067055e-01 0.972 0 0
HIV elongation arrest and recovery R-HSA-167287 1.071916e-01 0.970 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.071916e-01 0.970 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.071916e-01 0.970 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.089148e-01 0.963 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.092648e-01 0.962 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.362237e-01 0.866 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.171914e-01 0.931 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.171914e-01 0.931 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.416347e-01 0.849 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.142955e-01 0.942 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.142955e-01 0.942 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.142955e-01 0.942 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.142955e-01 0.942 1 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.142955e-01 0.942 1 1
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.142955e-01 0.942 1 1
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.142955e-01 0.942 1 1
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.142955e-01 0.942 1 1
Formation of axial mesoderm R-HSA-9796292 1.302533e-01 0.885 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.134936e-01 0.945 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.493422e-01 0.826 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.251470e-01 0.903 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.131379e-01 0.946 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.431558e-01 0.844 0 0
HCMV Early Events R-HSA-9609690 1.163478e-01 0.934 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.134936e-01 0.945 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.142955e-01 0.942 0 0
Developmental Cell Lineages R-HSA-9734767 1.451771e-01 0.838 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.274651e-01 0.895 0 0
Signaling by WNT in cancer R-HSA-4791275 1.493422e-01 0.826 1 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.274651e-01 0.895 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.469386e-01 0.833 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.469386e-01 0.833 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.384038e-01 0.859 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.416347e-01 0.849 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.416347e-01 0.849 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.142955e-01 0.942 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.163478e-01 0.934 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.192383e-01 0.924 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.192383e-01 0.924 0 0
Adherens junctions interactions R-HSA-418990 1.131741e-01 0.946 0 0
Cell-cell junction organization R-HSA-421270 1.461767e-01 0.835 0 0
Inhibition of PKR R-HSA-169131 1.362237e-01 0.866 0 0
CREB phosphorylation R-HSA-199920 1.416347e-01 0.849 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.131379e-01 0.946 0 0
ESR-mediated signaling R-HSA-8939211 1.391214e-01 0.857 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.314069e-01 0.881 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.251470e-01 0.903 0 0
Ca2+ pathway R-HSA-4086398 1.451441e-01 0.838 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.307661e-01 0.884 0 0
FLT3 Signaling R-HSA-9607240 1.439972e-01 0.842 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.493422e-01 0.826 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.171914e-01 0.931 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.171914e-01 0.931 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.469386e-01 0.833 0 0
Ub-specific processing proteases R-HSA-5689880 1.192383e-01 0.924 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.416347e-01 0.849 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.385680e-01 0.858 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.378582e-01 0.861 0 0
DNA Damage Bypass R-HSA-73893 1.291373e-01 0.889 0 0
Cell Cycle Checkpoints R-HSA-69620 1.267067e-01 0.897 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.251470e-01 0.903 0 0
Interleukin-17 signaling R-HSA-448424 1.238717e-01 0.907 0 0
Signal transduction by L1 R-HSA-445144 1.134936e-01 0.945 0 0
Influenza Infection R-HSA-168255 1.454668e-01 0.837 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.257656e-01 0.900 0 0
Regulation of beta-cell development R-HSA-186712 1.232493e-01 0.909 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.172521e-01 0.931 0 0
Interleukin-15 signaling R-HSA-8983432 1.142955e-01 0.942 0 0
Glycolysis R-HSA-70171 1.205575e-01 0.919 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.498095e-01 0.824 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.521546e-01 0.818 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.526201e-01 0.816 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.538822e-01 0.813 0 0
mRNA 3'-end processing R-HSA-72187 1.551156e-01 0.809 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.562749e-01 0.806 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.590857e-01 0.798 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.600322e-01 0.796 0 0
IGF1R signaling cascade R-HSA-2428924 1.627832e-01 0.788 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.972155e-01 0.705 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.972155e-01 0.705 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.539040e-01 0.595 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.539040e-01 0.595 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.539040e-01 0.595 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 2.539040e-01 0.595 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.539040e-01 0.595 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.539040e-01 0.595 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 3.065927e-01 0.513 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.065927e-01 0.513 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.065927e-01 0.513 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.931183e-01 0.714 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.931183e-01 0.714 0 0
ARMS-mediated activation R-HSA-170984 2.196785e-01 0.658 0 0
WNT mediated activation of DVL R-HSA-201688 2.196785e-01 0.658 0 0
ALK mutants bind TKIs R-HSA-9700645 2.196785e-01 0.658 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.555634e-01 0.449 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.555634e-01 0.449 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 3.555634e-01 0.449 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.555634e-01 0.449 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 1.642707e-01 0.784 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.642707e-01 0.784 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.642707e-01 0.784 1 1
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 2.465129e-01 0.608 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.465129e-01 0.608 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.821697e-01 0.740 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.821697e-01 0.740 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.005569e-01 0.698 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.005569e-01 0.698 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.005569e-01 0.698 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.734508e-01 0.563 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.010784e-01 0.397 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 4.010784e-01 0.397 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.010784e-01 0.397 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.010784e-01 0.397 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.193558e-01 0.659 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.798096e-01 0.745 0 0
Deadenylation of mRNA R-HSA-429947 1.798096e-01 0.745 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 3.003439e-01 0.522 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.003439e-01 0.522 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.384923e-01 0.623 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.270643e-01 0.485 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.270643e-01 0.485 0 0
GRB2 events in EGFR signaling R-HSA-179812 3.270643e-01 0.485 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.433813e-01 0.353 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 4.433813e-01 0.353 0 0
Phosphorylation of Emi1 R-HSA-176417 4.433813e-01 0.353 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 4.433813e-01 0.353 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 4.433813e-01 0.353 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 4.433813e-01 0.353 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 4.433813e-01 0.353 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 4.433813e-01 0.353 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.433813e-01 0.353 0 0
RAF activation R-HSA-5673000 1.848357e-01 0.733 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.245302e-01 0.649 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.245302e-01 0.649 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.245302e-01 0.649 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.400344e-01 0.620 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.535024e-01 0.452 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.535024e-01 0.452 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.972361e-01 0.527 0 0
Meiotic synapsis R-HSA-1221632 1.642727e-01 0.784 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.557749e-01 0.592 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.073998e-01 0.683 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.073998e-01 0.683 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.073998e-01 0.683 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.717150e-01 0.566 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.795650e-01 0.421 0 0
Retrograde neurotrophin signalling R-HSA-177504 3.795650e-01 0.421 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.795650e-01 0.421 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.826987e-01 0.316 0 0
Signaling by LTK in cancer R-HSA-9842640 4.826987e-01 0.316 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.826987e-01 0.316 0 0
STAT5 Activation R-HSA-9645135 4.826987e-01 0.316 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 4.826987e-01 0.316 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.826987e-01 0.316 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 4.826987e-01 0.316 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 4.826987e-01 0.316 0 0
FGFR2 alternative splicing R-HSA-6803529 3.368803e-01 0.473 0 0
Notch-HLH transcription pathway R-HSA-350054 3.368803e-01 0.473 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.633409e-01 0.579 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.644177e-01 0.784 0 0
Erythropoietin activates RAS R-HSA-9027284 4.051732e-01 0.392 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.051732e-01 0.392 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.051732e-01 0.392 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.051732e-01 0.392 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.566778e-01 0.448 0 0
Striated Muscle Contraction R-HSA-390522 3.367666e-01 0.473 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.763927e-01 0.424 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.302614e-01 0.366 0 0
Phosphorylation of the APC/C R-HSA-176412 4.302614e-01 0.366 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 3.959801e-01 0.402 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.035088e-01 0.518 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.023330e-01 0.395 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.786708e-01 0.320 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.786708e-01 0.320 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 4.786708e-01 0.320 0 0
mRNA Splicing R-HSA-72172 2.153919e-01 0.667 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.535850e-01 0.343 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.192964e-01 0.377 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.188747e-01 0.378 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.188747e-01 0.378 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.906929e-01 0.309 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 3.660534e-01 0.436 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.571420e-01 0.340 0 0
Transcription of the HIV genome R-HSA-167172 4.823183e-01 0.317 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.786708e-01 0.320 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.786708e-01 0.320 0 0
HIV Transcription Elongation R-HSA-167169 4.507590e-01 0.346 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.717150e-01 0.566 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.842352e-01 0.415 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.456945e-01 0.351 0 0
Integrin signaling R-HSA-354192 3.203778e-01 0.494 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.507590e-01 0.346 0 0
Aggrephagy R-HSA-9646399 4.507590e-01 0.346 0 0
Pexophagy R-HSA-9664873 2.465129e-01 0.608 0 0
Nephrin family interactions R-HSA-373753 2.774982e-01 0.557 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.196785e-01 0.658 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.798096e-01 0.745 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.566778e-01 0.448 0 0
MAP2K and MAPK activation R-HSA-5674135 4.823356e-01 0.317 0 0
GAB1 signalosome R-HSA-180292 2.384923e-01 0.623 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.547752e-01 0.342 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.670289e-01 0.777 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.931183e-01 0.714 0 0
PI3K/AKT activation R-HSA-198203 2.465129e-01 0.608 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.734508e-01 0.563 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 2.734508e-01 0.563 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.302614e-01 0.366 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.347374e-01 0.362 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.384923e-01 0.623 0 0
Adipogenesis R-HSA-9843745 2.850381e-01 0.545 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.531859e-01 0.452 0 0
Signaling by RAS mutants R-HSA-6802949 2.073998e-01 0.683 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.859971e-01 0.413 0 0
RNA Polymerase III Transcription R-HSA-74158 3.859971e-01 0.413 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.555634e-01 0.449 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.005569e-01 0.698 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.010784e-01 0.397 0 0
Trafficking of AMPA receptors R-HSA-399719 2.878186e-01 0.541 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.713261e-01 0.766 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.833297e-01 0.548 0 0
Integration of provirus R-HSA-162592 3.003439e-01 0.522 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.616350e-01 0.336 0 0
Generation of second messenger molecules R-HSA-202433 2.633409e-01 0.579 0 0
MET activates RAS signaling R-HSA-8851805 3.270643e-01 0.485 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.005569e-01 0.698 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.005569e-01 0.698 0 0
Formation of the posterior neural plate R-HSA-9832991 2.734508e-01 0.563 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.010784e-01 0.397 0 0
Killing mechanisms R-HSA-9664420 4.302614e-01 0.366 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.302614e-01 0.366 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.722877e-01 0.326 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.906929e-01 0.309 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.531405e-01 0.344 0 0
Signaling by NOTCH3 R-HSA-9012852 3.162872e-01 0.500 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.417987e-01 0.617 0 0
Recycling pathway of L1 R-HSA-437239 3.764250e-01 0.424 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.507590e-01 0.346 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.507590e-01 0.346 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.823183e-01 0.317 0 0
Prolonged ERK activation events R-HSA-169893 4.302614e-01 0.366 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.153990e-01 0.382 0 0
Circadian clock R-HSA-9909396 4.010711e-01 0.397 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.535024e-01 0.452 0 0
Meiosis R-HSA-1500620 3.727844e-01 0.429 0 0
HSF1-dependent transactivation R-HSA-3371571 4.334905e-01 0.363 0 0
Signaling by SCF-KIT R-HSA-1433557 1.745110e-01 0.758 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.092994e-01 0.679 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.531859e-01 0.452 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.092994e-01 0.679 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.433813e-01 0.353 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.368803e-01 0.473 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.238032e-01 0.650 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.786708e-01 0.320 0 0
Insulin receptor signalling cascade R-HSA-74751 4.316821e-01 0.365 0 0
Autophagy R-HSA-9612973 2.127899e-01 0.672 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.802937e-01 0.420 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.802937e-01 0.420 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.802937e-01 0.420 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.802937e-01 0.420 0 0
Kinesins R-HSA-983189 3.802937e-01 0.420 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.666316e-01 0.331 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.906929e-01 0.309 0 0
Selective autophagy R-HSA-9663891 4.165215e-01 0.380 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.972982e-01 0.705 0 0
HCMV Infection R-HSA-9609646 4.201628e-01 0.377 0 0
p75NTR signals via NF-kB R-HSA-193639 1.642707e-01 0.784 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.823356e-01 0.317 0 0
Macroautophagy R-HSA-1632852 1.893826e-01 0.723 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.432443e-01 0.464 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.416818e-01 0.617 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 1.972155e-01 0.705 0 0
Transport of connexins along the secretory pathway R-HSA-190827 1.972155e-01 0.705 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 2.539040e-01 0.595 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.539040e-01 0.595 0 0
Regulation of PTEN localization R-HSA-8948747 1.670289e-01 0.777 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.642707e-01 0.784 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.465129e-01 0.608 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.734508e-01 0.563 0 0
Reelin signalling pathway R-HSA-8866376 4.010784e-01 0.397 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.656260e-01 0.781 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 4.433813e-01 0.353 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.535024e-01 0.452 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.535024e-01 0.452 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.535024e-01 0.452 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.826987e-01 0.316 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.451453e-01 0.611 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.367666e-01 0.473 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.763927e-01 0.424 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 4.302614e-01 0.366 0 0
Signalling to ERKs R-HSA-187687 3.696056e-01 0.432 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.535850e-01 0.343 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.476085e-01 0.349 0 0
Vesicle-mediated transport R-HSA-5653656 3.029238e-01 0.519 0 0
Heme signaling R-HSA-9707616 2.560473e-01 0.592 0 0
Co-inhibition by PD-1 R-HSA-389948 4.374667e-01 0.359 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.707310e-01 0.431 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.825085e-01 0.417 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.834196e-01 0.737 0 0
Gene expression (Transcription) R-HSA-74160 4.673935e-01 0.330 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.834196e-01 0.737 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.036074e-01 0.691 0 0
Cellular responses to stress R-HSA-2262752 2.955066e-01 0.529 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.578957e-01 0.589 0 0
IRS-mediated signalling R-HSA-112399 3.417590e-01 0.466 0 0
Smooth Muscle Contraction R-HSA-445355 2.911316e-01 0.536 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.036074e-01 0.691 0 0
Calmodulin induced events R-HSA-111933 2.100398e-01 0.678 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.343934e-01 0.630 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.547752e-01 0.342 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.066127e-01 0.685 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.535850e-01 0.343 0 0
FLT3 signaling in disease R-HSA-9682385 3.859971e-01 0.413 0 0
Cellular responses to stimuli R-HSA-8953897 3.168195e-01 0.499 0 0
Negative regulation of FLT3 R-HSA-9706369 1.821697e-01 0.740 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.774982e-01 0.557 0 0
CaM pathway R-HSA-111997 2.100398e-01 0.678 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.972361e-01 0.527 0 0
Reproduction R-HSA-1474165 1.898903e-01 0.721 0 0
PLC beta mediated events R-HSA-112043 3.931674e-01 0.405 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 3.555634e-01 0.449 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.010784e-01 0.397 0 0
Signaling by LTK R-HSA-9842663 3.270643e-01 0.485 0 0
Pervasive developmental disorders R-HSA-9005895 3.270643e-01 0.485 0 0
Disorders of Nervous System Development R-HSA-9697154 3.270643e-01 0.485 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.270643e-01 0.485 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.459438e-01 0.609 0 0
Signaling by NOTCH1 R-HSA-1980143 1.681243e-01 0.774 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.411853e-01 0.618 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.188747e-01 0.378 0 0
Signaling by PTK6 R-HSA-8848021 4.188747e-01 0.378 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 4.302614e-01 0.366 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.153990e-01 0.382 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.512977e-01 0.346 0 0
Ca-dependent events R-HSA-111996 3.051249e-01 0.516 0 0
TCR signaling R-HSA-202403 4.036477e-01 0.394 0 0
Neurodegenerative Diseases R-HSA-8863678 3.763927e-01 0.424 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.763927e-01 0.424 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.302614e-01 0.366 0 0
DAG and IP3 signaling R-HSA-1489509 3.477838e-01 0.459 0 0
HDMs demethylate histones R-HSA-3214842 1.943800e-01 0.711 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.188240e-01 0.660 0 0
Ion transport by P-type ATPases R-HSA-936837 4.316821e-01 0.365 0 0
Regulation of TP53 Activity R-HSA-5633007 1.656537e-01 0.781 0 0
PI Metabolism R-HSA-1483255 2.115058e-01 0.675 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.477838e-01 0.459 0 0
MHC class II antigen presentation R-HSA-2132295 4.208061e-01 0.376 0 0
Protein ubiquitination R-HSA-8852135 4.060855e-01 0.391 0 0
Inhibition of membrane repair R-HSA-9635644 1.972155e-01 0.705 0 0
Oligomerization of connexins into connexons R-HSA-190704 1.972155e-01 0.705 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.642707e-01 0.784 0 0
2-LTR circle formation R-HSA-164843 2.465129e-01 0.608 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.003439e-01 0.522 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.433813e-01 0.353 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.433813e-01 0.353 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.203778e-01 0.494 0 0
Disorders of Developmental Biology R-HSA-9675151 4.547752e-01 0.342 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.346119e-01 0.362 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.837056e-01 0.416 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.245302e-01 0.649 0 0
G-protein mediated events R-HSA-112040 4.697712e-01 0.328 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.684260e-01 0.571 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.557749e-01 0.592 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.897276e-01 0.722 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.802937e-01 0.420 0 0
Signaling by NTRKs R-HSA-166520 1.658266e-01 0.780 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.897276e-01 0.722 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.535024e-01 0.452 0 0
PECAM1 interactions R-HSA-210990 2.734508e-01 0.563 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.734508e-01 0.563 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.023330e-01 0.395 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.786708e-01 0.320 0 0
Interleukin-37 signaling R-HSA-9008059 4.906929e-01 0.309 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.477204e-01 0.606 0 0
L1CAM interactions R-HSA-373760 2.492998e-01 0.603 0 0
Potential therapeutics for SARS R-HSA-9679191 4.585178e-01 0.339 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.642707e-01 0.784 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.815110e-01 0.741 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.815110e-01 0.741 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.815110e-01 0.741 0 0
Gastrulation R-HSA-9758941 2.480328e-01 0.605 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.367666e-01 0.473 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.769441e-01 0.558 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.196785e-01 0.658 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.010784e-01 0.397 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 4.433813e-01 0.353 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 4.433813e-01 0.353 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.203778e-01 0.494 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.302614e-01 0.366 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.347374e-01 0.362 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.722877e-01 0.326 0 0
Elastic fibre formation R-HSA-1566948 4.185879e-01 0.378 0 0
Toll-like Receptor Cascades R-HSA-168898 4.705557e-01 0.327 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.859971e-01 0.413 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.337847e-01 0.631 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.117836e-01 0.506 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.270643e-01 0.485 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.712320e-01 0.327 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.196785e-01 0.658 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.368803e-01 0.473 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.782180e-01 0.320 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.010784e-01 0.397 0 0
Signal regulatory protein family interactions R-HSA-391160 3.795650e-01 0.421 0 0
Formation of the anterior neural plate R-HSA-9823739 4.051732e-01 0.392 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.051732e-01 0.392 0 0
Syndecan interactions R-HSA-3000170 3.566778e-01 0.448 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.748973e-01 0.426 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.346119e-01 0.362 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.852286e-01 0.732 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.786708e-01 0.320 0 0
Netrin-1 signaling R-HSA-373752 1.852286e-01 0.732 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.578928e-01 0.446 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.073998e-01 0.683 0 0
Josephin domain DUBs R-HSA-5689877 2.465129e-01 0.608 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.656260e-01 0.781 0 0
PI3K Cascade R-HSA-109704 4.192964e-01 0.377 0 0
Programmed Cell Death R-HSA-5357801 2.209252e-01 0.656 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.051732e-01 0.392 0 0
Interleukin-2 family signaling R-HSA-451927 4.507590e-01 0.346 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.010784e-01 0.397 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.302614e-01 0.366 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.644177e-01 0.784 0 0
Signaling by Leptin R-HSA-2586552 2.465129e-01 0.608 0 0
tRNA processing R-HSA-72306 4.122803e-01 0.385 0 0
Glucose metabolism R-HSA-70326 2.571954e-01 0.590 0 0
Signaling by Interleukins R-HSA-449147 2.618675e-01 0.582 0 0
IRE1alpha activates chaperones R-HSA-381070 2.111198e-01 0.675 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.444418e-01 0.352 0 0
SLC transporter disorders R-HSA-5619102 4.869911e-01 0.312 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.978528e-01 0.303 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.978528e-01 0.303 0 0
Metabolism of RNA R-HSA-8953854 5.012325e-01 0.300 0 0
FGFR1 ligand binding and activation R-HSA-190242 5.019132e-01 0.299 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.019132e-01 0.299 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.019132e-01 0.299 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.019132e-01 0.299 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.019132e-01 0.299 0 0
Nephron development R-HSA-9831926 5.019132e-01 0.299 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.030221e-01 0.298 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.087765e-01 0.293 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.087765e-01 0.293 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.087765e-01 0.293 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.092530e-01 0.293 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.105671e-01 0.292 0 0
DNA Repair R-HSA-73894 5.124693e-01 0.290 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 5.192410e-01 0.285 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 5.192410e-01 0.285 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.192410e-01 0.285 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.192410e-01 0.285 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.192410e-01 0.285 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.192410e-01 0.285 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 5.192410e-01 0.285 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.192410e-01 0.285 0 0
VLDL clearance R-HSA-8964046 5.192410e-01 0.285 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.192410e-01 0.285 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.192410e-01 0.285 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.192410e-01 0.285 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 5.192410e-01 0.285 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.240520e-01 0.281 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.244754e-01 0.280 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.244754e-01 0.280 0 0
Rap1 signalling R-HSA-392517 5.244754e-01 0.280 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.244754e-01 0.280 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.244754e-01 0.280 0 0
G0 and Early G1 R-HSA-1538133 5.265173e-01 0.279 0 0
Dual incision in TC-NER R-HSA-6782135 5.299083e-01 0.276 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.314855e-01 0.275 0 0
Signaling by NOTCH R-HSA-157118 5.345796e-01 0.272 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.431253e-01 0.265 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.434762e-01 0.265 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.434762e-01 0.265 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.438971e-01 0.264 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.438971e-01 0.264 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.438971e-01 0.264 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.463376e-01 0.263 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.463376e-01 0.263 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.463376e-01 0.263 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.463376e-01 0.263 0 0
Signaling by NODAL R-HSA-1181150 5.463376e-01 0.263 0 0
Protein hydroxylation R-HSA-9629569 5.463376e-01 0.263 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 5.463376e-01 0.263 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.490073e-01 0.260 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.532040e-01 0.257 0 0
MET receptor recycling R-HSA-8875656 5.532040e-01 0.257 0 0
FGFR1b ligand binding and activation R-HSA-190370 5.532040e-01 0.257 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.532040e-01 0.257 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.532040e-01 0.257 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.532040e-01 0.257 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.532040e-01 0.257 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.532040e-01 0.257 0 0
Alpha-defensins R-HSA-1462054 5.532040e-01 0.257 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.532040e-01 0.257 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.561262e-01 0.255 0 0
Signaling by ERBB2 R-HSA-1227986 5.561262e-01 0.255 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.577437e-01 0.254 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.577437e-01 0.254 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.577437e-01 0.254 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.658580e-01 0.247 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.670397e-01 0.246 0 0
Centrosome maturation R-HSA-380287 5.670397e-01 0.246 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.670397e-01 0.246 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.670397e-01 0.246 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.674861e-01 0.246 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.674861e-01 0.246 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.674861e-01 0.246 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.674861e-01 0.246 0 0
Signalling to RAS R-HSA-167044 5.674861e-01 0.246 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.674861e-01 0.246 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.732457e-01 0.242 0 0
Signaling by VEGF R-HSA-194138 5.736285e-01 0.241 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.742487e-01 0.241 0 0
Interleukin-1 signaling R-HSA-9020702 5.751887e-01 0.240 0 0
Dual Incision in GG-NER R-HSA-5696400 5.775131e-01 0.238 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.775131e-01 0.238 0 0
UCH proteinases R-HSA-5689603 5.785984e-01 0.238 0 0
Interleukin-12 signaling R-HSA-9020591 5.785984e-01 0.238 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.816009e-01 0.235 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.847695e-01 0.233 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.847695e-01 0.233 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 5.847695e-01 0.233 0 0
Calcineurin activates NFAT R-HSA-2025928 5.847695e-01 0.233 0 0
Lipophagy R-HSA-9613354 5.847695e-01 0.233 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.847695e-01 0.233 0 0
Unwinding of DNA R-HSA-176974 5.847695e-01 0.233 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.847695e-01 0.233 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.847695e-01 0.233 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 5.847695e-01 0.233 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.847695e-01 0.233 0 0
Regulation of signaling by NODAL R-HSA-1433617 5.847695e-01 0.233 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.847695e-01 0.233 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.847695e-01 0.233 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.847695e-01 0.233 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.862034e-01 0.232 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.862034e-01 0.232 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.879126e-01 0.231 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.879126e-01 0.231 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.879126e-01 0.231 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.929019e-01 0.227 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.937252e-01 0.226 0 0
PERK regulates gene expression R-HSA-381042 5.937252e-01 0.226 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.976137e-01 0.224 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.976137e-01 0.224 0 0
Gap junction trafficking and regulation R-HSA-157858 6.000261e-01 0.222 0 0
Degradation of CDH1 R-HSA-9766229 6.000261e-01 0.222 0 0
PCP/CE pathway R-HSA-4086400 6.012381e-01 0.221 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.062699e-01 0.217 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.076136e-01 0.216 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.076136e-01 0.216 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.076136e-01 0.216 0 0
Signaling by KIT in disease R-HSA-9669938 6.076136e-01 0.216 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.076136e-01 0.216 0 0
LDL clearance R-HSA-8964038 6.076136e-01 0.216 0 0
RET signaling R-HSA-8853659 6.095276e-01 0.215 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.141068e-01 0.212 0 0
Binding and entry of HIV virion R-HSA-173107 6.141068e-01 0.212 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.141068e-01 0.212 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.141068e-01 0.212 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.141068e-01 0.212 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.141068e-01 0.212 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.141068e-01 0.212 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.142060e-01 0.212 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.142060e-01 0.212 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.172944e-01 0.210 0 0
Signaling by Insulin receptor R-HSA-74752 6.181052e-01 0.209 0 0
Degradation of DVL R-HSA-4641258 6.249136e-01 0.204 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.265896e-01 0.203 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.265896e-01 0.203 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.265896e-01 0.203 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.265896e-01 0.203 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 6.265896e-01 0.203 0 0
Growth hormone receptor signaling R-HSA-982772 6.265896e-01 0.203 0 0
HCMV Late Events R-HSA-9610379 6.286062e-01 0.202 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.339243e-01 0.198 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.380144e-01 0.195 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.397798e-01 0.194 0 0
Neurexins and neuroligins R-HSA-6794361 6.397798e-01 0.194 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.413729e-01 0.193 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.413729e-01 0.193 0 0
LGI-ADAM interactions R-HSA-5682910 6.413729e-01 0.193 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.413729e-01 0.193 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.413729e-01 0.193 0 0
vRNA Synthesis R-HSA-192814 6.413729e-01 0.193 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.413729e-01 0.193 0 0
Bicarbonate transporters R-HSA-425381 6.413729e-01 0.193 0 0
Transport of RCbl within the body R-HSA-9758890 6.413729e-01 0.193 0 0
Dissolution of Fibrin Clot R-HSA-75205 6.413729e-01 0.193 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.423760e-01 0.192 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.448447e-01 0.191 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.448447e-01 0.191 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.524417e-01 0.185 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.524417e-01 0.185 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.528223e-01 0.185 0 0
Stabilization of p53 R-HSA-69541 6.544182e-01 0.184 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.549037e-01 0.184 0 0
SARS-CoV Infections R-HSA-9679506 6.549983e-01 0.184 1 0
Tight junction interactions R-HSA-420029 6.623860e-01 0.179 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.623860e-01 0.179 0 0
Interleukin-7 signaling R-HSA-1266695 6.623860e-01 0.179 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.648027e-01 0.177 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.649806e-01 0.177 0 0
Cilium Assembly R-HSA-5617833 6.664529e-01 0.176 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.667140e-01 0.176 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.667140e-01 0.176 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.667140e-01 0.176 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.667140e-01 0.176 0 0
NF-kB is activated and signals survival R-HSA-209560 6.667140e-01 0.176 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.667140e-01 0.176 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.667140e-01 0.176 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.667140e-01 0.176 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.667140e-01 0.176 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.667140e-01 0.176 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.685319e-01 0.175 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.685319e-01 0.175 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.685319e-01 0.175 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.685319e-01 0.175 0 0
Glycogen metabolism R-HSA-8982491 6.685319e-01 0.175 0 0
S Phase R-HSA-69242 6.698342e-01 0.174 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.715883e-01 0.173 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.768601e-01 0.170 0 0
HDACs deacetylate histones R-HSA-3214815 6.768601e-01 0.170 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.792233e-01 0.168 0 0
Metalloprotease DUBs R-HSA-5689901 6.792233e-01 0.168 0 0
TRP channels R-HSA-3295583 6.792233e-01 0.168 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.792233e-01 0.168 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.793730e-01 0.168 1 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.822191e-01 0.166 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.822191e-01 0.166 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.822191e-01 0.166 0 0
Signaling by FGFR R-HSA-190236 6.850716e-01 0.164 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.856324e-01 0.164 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.856324e-01 0.164 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.856324e-01 0.164 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.856324e-01 0.164 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.886124e-01 0.162 0 0
Signaling by FGFR1 R-HSA-5654736 6.886124e-01 0.162 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.902659e-01 0.161 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.902659e-01 0.161 0 0
Maple Syrup Urine Disease R-HSA-9865114 6.902659e-01 0.161 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.902659e-01 0.161 0 0
Regulation of IFNG signaling R-HSA-877312 6.902659e-01 0.161 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.902659e-01 0.161 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.902659e-01 0.161 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.902659e-01 0.161 0 0
OAS antiviral response R-HSA-8983711 6.902659e-01 0.161 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.919057e-01 0.160 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.953684e-01 0.158 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.953684e-01 0.158 0 0
Insulin processing R-HSA-264876 6.953684e-01 0.158 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.954809e-01 0.158 0 0
HIV Transcription Initiation R-HSA-167161 6.954809e-01 0.158 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.954809e-01 0.158 0 0
Intra-Golgi traffic R-HSA-6811438 6.954809e-01 0.158 0 0
Interleukin-1 family signaling R-HSA-446652 6.990609e-01 0.155 0 0
Regulation of CDH1 Function R-HSA-9764561 7.000587e-01 0.155 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.000587e-01 0.155 0 0
Interleukin-12 family signaling R-HSA-447115 7.037172e-01 0.153 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.061131e-01 0.151 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.108350e-01 0.148 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.108350e-01 0.148 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.111989e-01 0.148 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.121548e-01 0.147 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.121548e-01 0.147 0 0
Frs2-mediated activation R-HSA-170968 7.121548e-01 0.147 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.121548e-01 0.147 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.121548e-01 0.147 0 0
Signaling by ERBB4 R-HSA-1236394 7.161257e-01 0.145 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.197967e-01 0.143 0 0
Muscle contraction R-HSA-397014 7.197967e-01 0.143 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.207382e-01 0.142 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.220336e-01 0.141 0 0
Signaling by Erythropoietin R-HSA-9006335 7.256384e-01 0.139 0 0
Late endosomal microautophagy R-HSA-9615710 7.256384e-01 0.139 0 0
mRNA Capping R-HSA-72086 7.256384e-01 0.139 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 7.324980e-01 0.135 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 7.324980e-01 0.135 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.324980e-01 0.135 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.324980e-01 0.135 0 0
Physiological factors R-HSA-5578768 7.324980e-01 0.135 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.324980e-01 0.135 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.325640e-01 0.135 0 0
Gap junction trafficking R-HSA-190828 7.327412e-01 0.135 0 0
Cyclin D associated events in G1 R-HSA-69231 7.327412e-01 0.135 0 0
G1 Phase R-HSA-69236 7.327412e-01 0.135 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.361261e-01 0.133 0 0
Opioid Signalling R-HSA-111885 7.361261e-01 0.133 0 0
Activation of the pre-replicative complex R-HSA-68962 7.397950e-01 0.131 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.397950e-01 0.131 0 0
DAP12 signaling R-HSA-2424491 7.397950e-01 0.131 0 0
Activation of BH3-only proteins R-HSA-114452 7.397950e-01 0.131 0 0
Adaptive Immune System R-HSA-1280218 7.416947e-01 0.130 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.427917e-01 0.129 0 0
RSV-host interactions R-HSA-9833110 7.440458e-01 0.128 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.443337e-01 0.128 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.443337e-01 0.128 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.443337e-01 0.128 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.455098e-01 0.128 0 0
Homology Directed Repair R-HSA-5693538 7.491194e-01 0.125 0 0
Biotin transport and metabolism R-HSA-196780 7.514046e-01 0.124 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.514046e-01 0.124 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.514046e-01 0.124 0 0
p38MAPK events R-HSA-171007 7.514046e-01 0.124 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.514046e-01 0.124 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.527191e-01 0.123 0 0
Cargo concentration in the ER R-HSA-5694530 7.533223e-01 0.123 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.533223e-01 0.123 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.534270e-01 0.123 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.639253e-01 0.117 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.663113e-01 0.116 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.689760e-01 0.114 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.689760e-01 0.114 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.689760e-01 0.114 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.689760e-01 0.114 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.689760e-01 0.114 0 0
Differentiation of T cells R-HSA-9945266 7.689760e-01 0.114 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 7.689760e-01 0.114 0 0
Signaling by FGFR2 R-HSA-5654738 7.706516e-01 0.113 0 0
Interferon Signaling R-HSA-913531 7.725712e-01 0.112 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.725712e-01 0.112 0 0
Co-stimulation by CD28 R-HSA-389356 7.767101e-01 0.110 0 0
G-protein beta:gamma signalling R-HSA-397795 7.785625e-01 0.109 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.785625e-01 0.109 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.853063e-01 0.105 0 0
Phase 2 - plateau phase R-HSA-5576893 7.853063e-01 0.105 0 0
Fibronectin matrix formation R-HSA-1566977 7.853063e-01 0.105 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.853063e-01 0.105 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.853063e-01 0.105 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.853063e-01 0.105 0 0
Coenzyme A biosynthesis R-HSA-196783 7.853063e-01 0.105 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.853063e-01 0.105 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.867254e-01 0.104 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.867254e-01 0.104 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.869433e-01 0.104 0 0
Formation of the cornified envelope R-HSA-6809371 7.901524e-01 0.102 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.940124e-01 0.100 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.963654e-01 0.099 0 0
DNA Double Strand Break Response R-HSA-5693606 7.979643e-01 0.098 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.004832e-01 0.097 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.004832e-01 0.097 0 0
Glycogen storage diseases R-HSA-3229121 8.004832e-01 0.097 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.004832e-01 0.097 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.004832e-01 0.097 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.015103e-01 0.096 0 0
Signaling by NOTCH2 R-HSA-1980145 8.015103e-01 0.096 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.015103e-01 0.096 0 0
Mitophagy R-HSA-5205647 8.015103e-01 0.096 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.026646e-01 0.095 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.026646e-01 0.095 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.026646e-01 0.095 0 0
RNA Polymerase II Transcription R-HSA-73857 8.030783e-01 0.095 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.061628e-01 0.094 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.077799e-01 0.093 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.116860e-01 0.091 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.121732e-01 0.090 0 0
Regulation of Apoptosis R-HSA-169911 8.121732e-01 0.090 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.145532e-01 0.089 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.145532e-01 0.089 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.145881e-01 0.089 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.145881e-01 0.089 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.145881e-01 0.089 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.145881e-01 0.089 0 0
Tie2 Signaling R-HSA-210993 8.145881e-01 0.089 0 0
Polo-like kinase mediated events R-HSA-156711 8.145881e-01 0.089 0 0
Platelet sensitization by LDL R-HSA-432142 8.145881e-01 0.089 0 0
G2/M Transition R-HSA-69275 8.175617e-01 0.087 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.223214e-01 0.085 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.223214e-01 0.085 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.223214e-01 0.085 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.223214e-01 0.085 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.231188e-01 0.085 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.231188e-01 0.085 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.237257e-01 0.084 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.273702e-01 0.082 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.276967e-01 0.082 0 0
Regulation of signaling by CBL R-HSA-912631 8.276967e-01 0.082 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.276967e-01 0.082 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.276967e-01 0.082 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.276967e-01 0.082 0 0
The NLRP3 inflammasome R-HSA-844456 8.276967e-01 0.082 0 0
Other interleukin signaling R-HSA-449836 8.276967e-01 0.082 0 0
Specification of the neural plate border R-HSA-9834899 8.276967e-01 0.082 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.276967e-01 0.082 0 0
Translation initiation complex formation R-HSA-72649 8.313442e-01 0.080 0 0
Ion channel transport R-HSA-983712 8.316754e-01 0.080 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.319744e-01 0.080 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.362810e-01 0.078 0 0
Paracetamol ADME R-HSA-9753281 8.392388e-01 0.076 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.398792e-01 0.076 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.398792e-01 0.076 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.398792e-01 0.076 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.398792e-01 0.076 0 0
Glycogen synthesis R-HSA-3322077 8.398792e-01 0.076 0 0
MET promotes cell motility R-HSA-8875878 8.411515e-01 0.075 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.411515e-01 0.075 0 0
Mitochondrial biogenesis R-HSA-1592230 8.429949e-01 0.074 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.468120e-01 0.072 0 0
Ion homeostasis R-HSA-5578775 8.468120e-01 0.072 0 0
Neurotransmitter release cycle R-HSA-112310 8.493058e-01 0.071 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.498716e-01 0.071 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.498716e-01 0.071 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.498716e-01 0.071 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.512010e-01 0.070 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.512010e-01 0.070 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.512010e-01 0.070 0 0
ERK/MAPK targets R-HSA-198753 8.512010e-01 0.070 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.512010e-01 0.070 0 0
Basigin interactions R-HSA-210991 8.512010e-01 0.070 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.512010e-01 0.070 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.515252e-01 0.070 0 0
Attenuation phase R-HSA-3371568 8.581536e-01 0.066 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.581536e-01 0.066 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.581536e-01 0.066 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.610318e-01 0.065 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.615491e-01 0.065 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.617229e-01 0.065 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.617229e-01 0.065 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.617229e-01 0.065 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.617229e-01 0.065 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.617229e-01 0.065 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.617229e-01 0.065 0 0
Glutathione synthesis and recycling R-HSA-174403 8.617229e-01 0.065 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.617229e-01 0.065 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.623814e-01 0.064 0 0
Maturation of spike protein R-HSA-9694548 8.660157e-01 0.062 0 0
Synthesis of DNA R-HSA-69239 8.666642e-01 0.062 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.676975e-01 0.062 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.676975e-01 0.062 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.683222e-01 0.061 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.715014e-01 0.060 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.715014e-01 0.060 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.715014e-01 0.060 0 0
Ethanol oxidation R-HSA-71384 8.715014e-01 0.060 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.715014e-01 0.060 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 8.715014e-01 0.060 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.728478e-01 0.059 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.734759e-01 0.059 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.734759e-01 0.059 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.734759e-01 0.059 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.734759e-01 0.059 0 0
Transmission across Chemical Synapses R-HSA-112315 8.737112e-01 0.059 0 0
Integrin cell surface interactions R-HSA-216083 8.740411e-01 0.058 0 0
RNA Polymerase I Transcription R-HSA-73864 8.740411e-01 0.058 0 0
Interleukin-10 signaling R-HSA-6783783 8.740411e-01 0.058 0 0
tRNA Aminoacylation R-HSA-379724 8.740795e-01 0.058 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.764237e-01 0.057 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.784826e-01 0.056 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.795441e-01 0.056 0 0
Sensory processing of sound R-HSA-9659379 8.795441e-01 0.056 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.805517e-01 0.055 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.805889e-01 0.055 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.805889e-01 0.055 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.805889e-01 0.055 0 0
Carnitine shuttle R-HSA-200425 8.805889e-01 0.055 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.860300e-01 0.053 0 0
Signaling by FGFR4 R-HSA-5654743 8.872601e-01 0.052 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.890343e-01 0.051 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.890343e-01 0.051 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 8.890343e-01 0.051 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.890343e-01 0.051 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.899266e-01 0.051 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.910304e-01 0.050 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.916169e-01 0.050 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.916169e-01 0.050 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.926573e-01 0.049 0 0
DAP12 interactions R-HSA-2172127 8.936176e-01 0.049 0 0
RMTs methylate histone arginines R-HSA-3214858 8.936176e-01 0.049 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 8.936176e-01 0.049 0 0
Generic Transcription Pathway R-HSA-212436 8.944678e-01 0.048 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.968828e-01 0.047 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.968828e-01 0.047 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.968828e-01 0.047 0 0
Laminin interactions R-HSA-3000157 8.968828e-01 0.047 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.968828e-01 0.047 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.982269e-01 0.047 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.995174e-01 0.046 0 0
Nucleosome assembly R-HSA-774815 8.996404e-01 0.046 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.996404e-01 0.046 0 0
Signaling by FGFR3 R-HSA-5654741 8.996404e-01 0.046 0 0
Cellular response to hypoxia R-HSA-1234174 9.020592e-01 0.045 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.041766e-01 0.044 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.041766e-01 0.044 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.041766e-01 0.044 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.041766e-01 0.044 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.041766e-01 0.044 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.041766e-01 0.044 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.041766e-01 0.044 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.053440e-01 0.043 0 0
Interaction between L1 and Ankyrins R-HSA-445095 9.109549e-01 0.041 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.109549e-01 0.041 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.109549e-01 0.041 0 0
Triglyceride biosynthesis R-HSA-75109 9.109549e-01 0.041 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.109549e-01 0.041 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.109549e-01 0.041 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.109549e-01 0.041 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.115845e-01 0.040 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.119329e-01 0.040 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.125220e-01 0.040 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.160246e-01 0.038 0 0
Insulin receptor recycling R-HSA-77387 9.172542e-01 0.038 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.172542e-01 0.038 0 0
Telomere Extension By Telomerase R-HSA-171319 9.172542e-01 0.038 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.172542e-01 0.038 0 0
Inflammasomes R-HSA-622312 9.172542e-01 0.038 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.172542e-01 0.038 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.172542e-01 0.038 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.203374e-01 0.036 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.206867e-01 0.036 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.227425e-01 0.035 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.231081e-01 0.035 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.231081e-01 0.035 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.231081e-01 0.035 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.231081e-01 0.035 0 0
DARPP-32 events R-HSA-180024 9.231081e-01 0.035 0 0
Diseases of programmed cell death R-HSA-9645723 9.240054e-01 0.034 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.243004e-01 0.034 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.243004e-01 0.034 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.243004e-01 0.034 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.243004e-01 0.034 0 0
Viral Infection Pathways R-HSA-9824446 9.249123e-01 0.034 1 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.285482e-01 0.032 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.285482e-01 0.032 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.285482e-01 0.032 0 0
Chromosome Maintenance R-HSA-73886 9.292245e-01 0.032 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.293136e-01 0.032 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.295800e-01 0.032 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.295800e-01 0.032 0 0
Cellular response to chemical stress R-HSA-9711123 9.325657e-01 0.030 0 0
Budding and maturation of HIV virion R-HSA-162588 9.336038e-01 0.030 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.336038e-01 0.030 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.336038e-01 0.030 0 0
Downstream signal transduction R-HSA-186763 9.336038e-01 0.030 0 0
Orc1 removal from chromatin R-HSA-68949 9.336649e-01 0.030 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.336649e-01 0.030 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.336649e-01 0.030 0 0
PPARA activates gene expression R-HSA-1989781 9.368281e-01 0.028 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.375247e-01 0.028 0 0
Stimuli-sensing channels R-HSA-2672351 9.380477e-01 0.028 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.383019e-01 0.028 0 0
DNA strand elongation R-HSA-69190 9.383019e-01 0.028 0 0
Signaling by NOTCH4 R-HSA-9013694 9.386510e-01 0.027 0 0
Protein folding R-HSA-391251 9.401610e-01 0.027 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.404395e-01 0.027 0 0
Leishmania phagocytosis R-HSA-9664417 9.404395e-01 0.027 0 0
Parasite infection R-HSA-9664407 9.404395e-01 0.027 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.426679e-01 0.026 0 0
Cardiogenesis R-HSA-9733709 9.426679e-01 0.026 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.428708e-01 0.026 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.446138e-01 0.025 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.467251e-01 0.024 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.467251e-01 0.024 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.467251e-01 0.024 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.467251e-01 0.024 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.467251e-01 0.024 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.467251e-01 0.024 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.467251e-01 0.024 0 0
Heme degradation R-HSA-189483 9.467251e-01 0.024 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 9.478646e-01 0.023 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.478646e-01 0.023 0 0
Cholesterol biosynthesis R-HSA-191273 9.504481e-01 0.022 0 0
Gap junction assembly R-HSA-190861 9.504955e-01 0.022 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.504955e-01 0.022 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.504955e-01 0.022 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.504955e-01 0.022 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.504955e-01 0.022 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.504955e-01 0.022 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.504955e-01 0.022 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.504955e-01 0.022 0 0
Hyaluronan metabolism R-HSA-2142845 9.504955e-01 0.022 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.504955e-01 0.022 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.504955e-01 0.022 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.531274e-01 0.021 0 0
Neutrophil degranulation R-HSA-6798695 9.537484e-01 0.021 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.539992e-01 0.020 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.539992e-01 0.020 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.539992e-01 0.020 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.539992e-01 0.020 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.539992e-01 0.020 0 0
Telomere Maintenance R-HSA-157579 9.553883e-01 0.020 0 0
PKR-mediated signaling R-HSA-9833482 9.555192e-01 0.020 0 0
G1/S-Specific Transcription R-HSA-69205 9.572551e-01 0.019 0 0
HSF1 activation R-HSA-3371511 9.572551e-01 0.019 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.572551e-01 0.019 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.572551e-01 0.019 0 0
GPVI-mediated activation cascade R-HSA-114604 9.572551e-01 0.019 0 0
Voltage gated Potassium channels R-HSA-1296072 9.602808e-01 0.018 0 0
Degradation of AXIN R-HSA-4641257 9.602808e-01 0.018 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.602808e-01 0.018 0 0
NCAM1 interactions R-HSA-419037 9.602808e-01 0.018 0 0
ABC-family proteins mediated transport R-HSA-382556 9.615810e-01 0.017 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.630925e-01 0.016 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.630925e-01 0.016 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.630925e-01 0.016 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.638565e-01 0.016 0 0
Neddylation R-HSA-8951664 9.648768e-01 0.016 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.657053e-01 0.015 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.657053e-01 0.015 0 0
RAS processing R-HSA-9648002 9.657053e-01 0.015 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.660155e-01 0.015 0 0
DNA Replication R-HSA-69306 9.665001e-01 0.015 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.681332e-01 0.014 0 0
Diseases of Immune System R-HSA-5260271 9.681332e-01 0.014 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.681332e-01 0.014 0 0
Tryptophan catabolism R-HSA-71240 9.681332e-01 0.014 0 0
Immune System R-HSA-168256 9.690478e-01 0.014 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.703894e-01 0.013 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.703894e-01 0.013 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.703894e-01 0.013 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.703894e-01 0.013 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.703894e-01 0.013 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.703894e-01 0.013 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.717733e-01 0.012 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.724860e-01 0.012 1 1
Degradation of GLI2 by the proteasome R-HSA-5610783 9.724860e-01 0.012 1 1
Cellular response to starvation R-HSA-9711097 9.729371e-01 0.012 0 0
Kidney development R-HSA-9830369 9.734743e-01 0.012 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.744343e-01 0.011 0 0
Depyrimidination R-HSA-73928 9.744343e-01 0.011 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.744343e-01 0.011 0 0
G1/S Transition R-HSA-69206 9.755822e-01 0.011 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.756963e-01 0.011 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.756963e-01 0.011 0 0
Base Excision Repair R-HSA-73884 9.757479e-01 0.011 0 0
Downstream TCR signaling R-HSA-202424 9.757479e-01 0.011 0 0
Defective pyroptosis R-HSA-9710421 9.762447e-01 0.010 0 0
Defensins R-HSA-1461973 9.762447e-01 0.010 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.762447e-01 0.010 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.762447e-01 0.010 0 0
Neuronal System R-HSA-112316 9.774354e-01 0.010 0 0
G2/M Checkpoints R-HSA-69481 9.778369e-01 0.010 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.779270e-01 0.010 0 0
Surfactant metabolism R-HSA-5683826 9.779270e-01 0.010 0 0
Proteasome assembly R-HSA-9907900 9.779270e-01 0.010 0 0
Amine ligand-binding receptors R-HSA-375280 9.779270e-01 0.010 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.779270e-01 0.010 0 0
COPII-mediated vesicle transport R-HSA-204005 9.780036e-01 0.010 0 0
ECM proteoglycans R-HSA-3000178 9.793397e-01 0.009 0 0
Hedgehog 'on' state R-HSA-5632684 9.793397e-01 0.009 1 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.794903e-01 0.009 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.794903e-01 0.009 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.794903e-01 0.009 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.794903e-01 0.009 0 0
Somitogenesis R-HSA-9824272 9.794903e-01 0.009 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.802567e-01 0.009 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.802567e-01 0.009 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.805969e-01 0.009 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.806960e-01 0.008 0 0
Diseases of DNA repair R-HSA-9675135 9.809429e-01 0.008 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.809429e-01 0.008 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.809429e-01 0.008 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.809429e-01 0.008 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.814683e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.817099e-01 0.008 0 0
Peptide ligand-binding receptors R-HSA-375276 9.826177e-01 0.008 0 0
Cardiac conduction R-HSA-5576891 9.826514e-01 0.008 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.827210e-01 0.008 0 0
G2/M DNA damage checkpoint R-HSA-69473 9.828926e-01 0.007 0 0
Intraflagellar transport R-HSA-5620924 9.835471e-01 0.007 0 0
GPER1 signaling R-HSA-9634597 9.835471e-01 0.007 0 0
Gluconeogenesis R-HSA-70263 9.835471e-01 0.007 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.836785e-01 0.007 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.847126e-01 0.007 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.856098e-01 0.006 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.856098e-01 0.006 0 0
Azathioprine ADME R-HSA-9748787 9.857956e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9694635 9.858491e-01 0.006 1 0
Post-translational protein phosphorylation R-HSA-8957275 9.862557e-01 0.006 0 0
Regulation of insulin secretion R-HSA-422356 9.862557e-01 0.006 0 0
G alpha (q) signalling events R-HSA-416476 9.862795e-01 0.006 0 0
Meiotic recombination R-HSA-912446 9.868020e-01 0.006 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.868020e-01 0.006 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.868020e-01 0.006 0 0
The phototransduction cascade R-HSA-2514856 9.868020e-01 0.006 0 0
FOXO-mediated transcription R-HSA-9614085 9.870244e-01 0.006 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.875371e-01 0.005 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.877371e-01 0.005 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.883059e-01 0.005 0 0
Amyloid fiber formation R-HSA-977225 9.890284e-01 0.005 0 0
Interferon gamma signaling R-HSA-877300 9.892894e-01 0.005 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.894134e-01 0.005 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.894134e-01 0.005 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.903450e-01 0.004 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.908607e-01 0.004 0 0
Dectin-2 family R-HSA-5621480 9.915084e-01 0.004 0 0
Phospholipid metabolism R-HSA-1483257 9.916567e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.918554e-01 0.004 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.923136e-01 0.003 0 0
Platelet degranulation R-HSA-114608 9.924685e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.925317e-01 0.003 0 0
Peroxisomal protein import R-HSA-9033241 9.926695e-01 0.003 0 0
Extension of Telomeres R-HSA-180786 9.926695e-01 0.003 0 0
Triglyceride metabolism R-HSA-8979227 9.926695e-01 0.003 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.927524e-01 0.003 0 0
Keratinization R-HSA-6805567 9.931095e-01 0.003 0 0
Glutathione conjugation R-HSA-156590 9.931892e-01 0.003 0 0
Metabolism of polyamines R-HSA-351202 9.931892e-01 0.003 0 0
Peptide chain elongation R-HSA-156902 9.934352e-01 0.003 0 0
GPCR downstream signalling R-HSA-388396 9.936313e-01 0.003 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.936720e-01 0.003 0 0
ER-Phagosome pathway R-HSA-1236974 9.938459e-01 0.003 0 0
Mitochondrial protein import R-HSA-1268020 9.941206e-01 0.003 0 0
Signaling by PDGF R-HSA-186797 9.941206e-01 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.942314e-01 0.003 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.942773e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.943325e-01 0.002 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.943325e-01 0.002 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.945932e-01 0.002 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.948802e-01 0.002 0 0
Protein localization R-HSA-9609507 9.948975e-01 0.002 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.949328e-01 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.952118e-01 0.002 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.952514e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.952514e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.952514e-01 0.002 1 0
SARS-CoV-1 Infection R-HSA-9678108 9.953595e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.955503e-01 0.002 0 0
Integration of energy metabolism R-HSA-163685 9.959039e-01 0.002 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.959297e-01 0.002 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.960809e-01 0.002 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.960937e-01 0.002 0 0
O-linked glycosylation of mucins R-HSA-913709 9.962184e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.962303e-01 0.002 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.963405e-01 0.002 0 0
Eukaryotic Translation Termination R-HSA-72764 9.963405e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.965719e-01 0.001 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.969673e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.969673e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.969673e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.969673e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.971831e-01 0.001 0 0
Hedgehog 'off' state R-HSA-5610787 9.973620e-01 0.001 1 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.973823e-01 0.001 0 0
Selenocysteine synthesis R-HSA-2408557 9.975297e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.975681e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.977406e-01 0.001 0 0
Viral mRNA Translation R-HSA-192823 9.978342e-01 0.001 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.980511e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.981883e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.983966e-01 0.001 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.984363e-01 0.001 0 0
Leishmania infection R-HSA-9658195 9.986380e-01 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 9.986380e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.987236e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.988056e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.990165e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.990832e-01 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 9.991292e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.991989e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.991989e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.992249e-01 0.000 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.992789e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.994820e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.996142e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.996142e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.996611e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.996671e-01 0.000 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.997499e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997697e-01 0.000 0 0
Platelet homeostasis R-HSA-418346 9.998286e-01 0.000 0 0
Signaling by Hedgehog R-HSA-5358351 9.998610e-01 0.000 1 0
Mitochondrial translation termination R-HSA-5419276 9.998626e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998917e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999102e-01 0.000 1 0
Sphingolipid metabolism R-HSA-428157 9.999209e-01 0.000 0 0
rRNA processing R-HSA-72312 9.999463e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999500e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999511e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999589e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999636e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999686e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999779e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999827e-01 0.000 0 0
Disease R-HSA-1643685 9.999827e-01 0.000 1 0
Hemostasis R-HSA-109582 9.999834e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999869e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999877e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999880e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999888e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999938e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999947e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999958e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999967e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999985e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999986e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999988e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999993e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999993e-01 0.000 0 0
Translation R-HSA-72766 9.999993e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999997e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Activation of SMO R-HSA-5635838 1.000000e+00 0.000 1 1
Maturation of nucleoprotein R-HSA-9694631 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 2.220446e-16 15.654 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.771561e-16 15.109 0 0
Cell Cycle R-HSA-1640170 2.828737e-12 11.548 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.243350e-11 10.205 0 0
Attenuation phase R-HSA-3371568 2.015553e-10 9.696 0 0
HSF1-dependent transactivation R-HSA-3371571 4.906707e-10 9.309 0 0
M Phase R-HSA-68886 5.890600e-10 9.230 0 0
Mitotic Prometaphase R-HSA-68877 1.285384e-09 8.891 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.619059e-09 8.582 0 0
Cell Cycle, Mitotic R-HSA-69278 2.796882e-09 8.553 0 0
Mitotic Anaphase R-HSA-68882 4.905352e-09 8.309 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.601340e-09 8.252 0 0
HSF1 activation R-HSA-3371511 8.382180e-09 8.077 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.268112e-08 7.370 0 0
Separation of Sister Chromatids R-HSA-2467813 6.460823e-08 7.190 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.430746e-07 6.614 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.314821e-07 6.635 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.603034e-07 6.585 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.226015e-07 6.491 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.781534e-07 6.320 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.212057e-07 6.283 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.861186e-07 6.232 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.511317e-07 6.186 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.824464e-07 6.107 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.549152e-07 6.122 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.919598e-07 6.101 0 0
Metabolism of RNA R-HSA-8953854 8.690616e-07 6.061 0 0
Cell Cycle Checkpoints R-HSA-69620 1.452312e-06 5.838 0 0
mRNA Splicing R-HSA-72172 1.821164e-06 5.740 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.066390e-06 5.685 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.286002e-06 5.641 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.669352e-06 5.574 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.182431e-06 5.497 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.967621e-06 5.401 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.024531e-06 5.395 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.024531e-06 5.395 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.329306e-06 5.364 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.329306e-06 5.364 0 0
Apoptotic execution phase R-HSA-75153 4.848259e-06 5.314 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.324364e-06 5.274 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.324364e-06 5.274 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.847200e-06 5.164 0 0
Signal Transduction R-HSA-162582 7.120972e-06 5.147 1 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.774656e-06 5.109 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.774656e-06 5.109 0 0
Cellular responses to stress R-HSA-2262752 8.386605e-06 5.076 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.027376e-05 4.988 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.027376e-05 4.988 0 0
Cellular responses to stimuli R-HSA-8953897 1.100430e-05 4.958 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.145708e-05 4.941 0 0
Nuclear import of Rev protein R-HSA-180746 1.345831e-05 4.871 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.466175e-05 4.834 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.838535e-05 4.736 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.988267e-05 4.702 0 0
Metabolism of non-coding RNA R-HSA-194441 2.111348e-05 4.675 0 0
snRNP Assembly R-HSA-191859 2.111348e-05 4.675 0 0
Signaling by Hippo R-HSA-2028269 2.170757e-05 4.663 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.312574e-05 4.636 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.554117e-05 4.593 0 0
Apoptosis R-HSA-109581 3.414910e-05 4.467 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.661416e-05 4.436 0 0
tRNA processing in the nucleus R-HSA-6784531 3.692198e-05 4.433 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.047517e-05 4.393 0 0
Membrane Trafficking R-HSA-199991 4.066664e-05 4.391 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.176691e-05 4.286 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.787137e-05 4.238 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.919673e-05 4.160 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.206168e-05 4.142 0 0
Adherens junctions interactions R-HSA-418990 7.660022e-05 4.116 0 0
Cell-Cell communication R-HSA-1500931 8.841720e-05 4.053 0 0
ESR-mediated signaling R-HSA-8939211 8.964308e-05 4.047 0 0
G2/M Checkpoints R-HSA-69481 9.489432e-05 4.023 0 0
Mitotic Prophase R-HSA-68875 9.243091e-05 4.034 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.878291e-05 4.005 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.031542e-04 3.987 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.121511e-04 3.950 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.215991e-04 3.915 0 0
Cell junction organization R-HSA-446728 1.418606e-04 3.848 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.686456e-04 3.773 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.979687e-04 3.703 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.071490e-04 3.684 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.363408e-04 3.626 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.549100e-04 3.594 0 0
Activation of BH3-only proteins R-HSA-114452 2.808882e-04 3.551 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.600514e-04 3.444 0 0
Programmed Cell Death R-HSA-5357801 4.421676e-04 3.354 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.738019e-04 3.324 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.738019e-04 3.324 0 0
Cell-cell junction organization R-HSA-421270 4.992528e-04 3.302 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.281321e-04 3.277 1 0
PKR-mediated signaling R-HSA-9833482 5.756675e-04 3.240 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.229501e-04 3.206 0 0
Post NMDA receptor activation events R-HSA-438064 6.069248e-04 3.217 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.975295e-04 3.156 0 0
G2/M Transition R-HSA-69275 7.170606e-04 3.144 0 0
Aggrephagy R-HSA-9646399 7.352951e-04 3.134 0 0
L1CAM interactions R-HSA-373760 7.887641e-04 3.103 0 0
HCMV Early Events R-HSA-9609690 7.889927e-04 3.103 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 7.986234e-04 3.098 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.431148e-04 3.074 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.817379e-04 3.055 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.377700e-04 3.077 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.825329e-04 3.054 0 0
Recycling pathway of L1 R-HSA-437239 9.071552e-04 3.042 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.045264e-03 2.981 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.098678e-03 2.959 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.164684e-03 2.934 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.164684e-03 2.934 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.232169e-03 2.909 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.355614e-03 2.868 0 0
Regulation of CDH1 Function R-HSA-9764561 1.401672e-03 2.853 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.416926e-03 2.849 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.525202e-03 2.817 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.603123e-03 2.795 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.663900e-03 2.779 0 0
Selective autophagy R-HSA-9663891 1.678287e-03 2.775 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.729944e-03 2.762 0 0
mRNA 3'-end processing R-HSA-72187 1.937889e-03 2.713 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.082898e-03 2.681 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.928317e-03 2.715 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.107075e-03 2.676 0 0
Kinesins R-HSA-983189 2.107075e-03 2.676 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.155954e-03 2.666 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.317541e-03 2.635 0 0
Glycolysis R-HSA-70171 3.064168e-03 2.514 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.172187e-03 2.499 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.399093e-03 2.469 0 0
Gap junction trafficking and regulation R-HSA-157858 3.553365e-03 2.449 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.745981e-03 2.426 0 0
Gene expression (Transcription) R-HSA-74160 3.677159e-03 2.434 0 0
DNA Repair R-HSA-73894 3.528868e-03 2.452 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.974804e-03 2.401 0 0
HIV Life Cycle R-HSA-162587 4.056685e-03 2.392 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.382713e-03 2.358 0 0
Chromatin organization R-HSA-4839726 4.489907e-03 2.348 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.806907e-03 2.318 0 0
Centrosome maturation R-HSA-380287 4.936010e-03 2.307 0 0
Gap junction trafficking R-HSA-190828 4.945086e-03 2.306 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.382042e-03 2.269 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.516367e-03 2.258 0 0
Meiotic synapsis R-HSA-1221632 5.974743e-03 2.224 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.035799e-03 2.219 0 0
Meiosis R-HSA-1500620 5.940736e-03 2.226 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.035799e-03 2.219 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.050405e-03 2.218 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.121839e-03 2.213 0 0
Gene Silencing by RNA R-HSA-211000 6.279412e-03 2.202 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.279412e-03 2.202 0 0
Signaling by ALK in cancer R-HSA-9700206 6.279412e-03 2.202 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.562421e-03 2.183 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.855896e-03 2.164 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.191959e-03 2.143 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.217365e-03 2.142 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.598221e-03 2.119 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.920321e-03 2.101 0 0
Gap junction assembly R-HSA-190861 8.342846e-03 2.079 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.346744e-03 2.078 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.530150e-03 2.069 0 0
NRAGE signals death through JNK R-HSA-193648 8.530150e-03 2.069 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 8.784262e-03 2.056 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 8.784262e-03 2.056 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.995579e-03 2.000 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.483512e-03 2.023 0 0
Chromatin modifying enzymes R-HSA-3247509 9.469742e-03 2.024 0 0
Interferon Signaling R-HSA-913531 1.028304e-02 1.988 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.032200e-02 1.986 0 0
Cellular Senescence R-HSA-2559583 1.067667e-02 1.972 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.146864e-02 1.940 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.163586e-02 1.934 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.179218e-02 1.928 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.237964e-02 1.907 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.237964e-02 1.907 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.237964e-02 1.907 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.237964e-02 1.907 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.237964e-02 1.907 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.237964e-02 1.907 0 0
Vesicle-mediated transport R-HSA-5653656 1.300605e-02 1.886 0 0
HCMV Infection R-HSA-9609646 1.304362e-02 1.885 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.353871e-02 1.868 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.353950e-02 1.868 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.367436e-02 1.864 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.428428e-02 1.845 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.474116e-02 1.831 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.394649e-02 1.856 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.415966e-02 1.849 0 0
S Phase R-HSA-69242 1.400111e-02 1.854 0 0
Glucose metabolism R-HSA-70326 1.579552e-02 1.801 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.632698e-02 1.787 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.636844e-02 1.786 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.636844e-02 1.786 0 0
TGFBR3 expression R-HSA-9839394 1.636844e-02 1.786 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.792077e-02 1.747 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.792077e-02 1.747 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.792077e-02 1.747 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.792077e-02 1.747 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.835741e-02 1.736 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.865426e-02 1.729 0 0
Unwinding of DNA R-HSA-176974 1.880963e-02 1.726 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.907376e-02 1.720 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.948687e-02 1.710 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.948687e-02 1.710 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.948687e-02 1.710 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.948687e-02 1.710 0 0
Death Receptor Signaling R-HSA-73887 2.011827e-02 1.696 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.135150e-02 1.671 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.135150e-02 1.671 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.430494e-02 1.614 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.251400e-02 1.648 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.430494e-02 1.614 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.348657e-02 1.629 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.207737e-02 1.656 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.127132e-02 1.672 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.251400e-02 1.648 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.207737e-02 1.656 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.354299e-02 1.628 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.274891e-02 1.643 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.251400e-02 1.648 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.145159e-02 1.669 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.454870e-02 1.610 0 0
DNA Double Strand Break Response R-HSA-5693606 2.566008e-02 1.591 0 0
MTOR signalling R-HSA-165159 2.622813e-02 1.581 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.637972e-02 1.579 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.654028e-02 1.576 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.706363e-02 1.568 0 0
Signaling by TGFB family members R-HSA-9006936 2.814235e-02 1.551 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.903440e-02 1.537 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.000930e-02 1.523 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.000930e-02 1.523 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.015211e-02 1.521 0 0
Cilium Assembly R-HSA-5617833 3.071307e-02 1.513 0 0
G alpha (12/13) signalling events R-HSA-416482 3.082066e-02 1.511 0 0
Homology Directed Repair R-HSA-5693538 3.104836e-02 1.508 0 0
mTORC1-mediated signalling R-HSA-166208 3.139165e-02 1.503 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.244493e-02 1.489 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.254460e-02 1.488 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.305923e-02 1.481 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.323021e-02 1.478 0 0
CREB phosphorylation R-HSA-199920 4.024281e-02 1.395 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 4.024281e-02 1.395 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.845563e-02 1.415 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.845563e-02 1.415 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.869810e-02 1.412 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.834056e-02 1.416 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.845563e-02 1.415 0 0
Deubiquitination R-HSA-5688426 3.960181e-02 1.402 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.733819e-02 1.428 0 0
Signaling by TGFBR3 R-HSA-9839373 3.953514e-02 1.403 0 0
Inositol phosphate metabolism R-HSA-1483249 3.386898e-02 1.470 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.029654e-02 1.395 0 0
HIV Infection R-HSA-162906 4.392408e-02 1.357 0 0
Host Interactions of HIV factors R-HSA-162909 4.427091e-02 1.354 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.443223e-02 1.352 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.443223e-02 1.352 0 0
Regulation of TP53 Expression R-HSA-6804754 4.443223e-02 1.352 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.443223e-02 1.352 0 0
C6 deamination of adenosine R-HSA-75102 4.443223e-02 1.352 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.443223e-02 1.352 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.443223e-02 1.352 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.443223e-02 1.352 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.443223e-02 1.352 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.443223e-02 1.352 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.443223e-02 1.352 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.443223e-02 1.352 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.443223e-02 1.352 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.443223e-02 1.352 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.443223e-02 1.352 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.459474e-02 1.351 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.471347e-02 1.350 0 0
Signaling by EGFR R-HSA-177929 4.471347e-02 1.350 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.498086e-02 1.347 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.498086e-02 1.347 0 0
Macroautophagy R-HSA-1632852 4.570625e-02 1.340 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.610695e-02 1.336 0 0
Regulation of TP53 Activity R-HSA-5633007 4.645482e-02 1.333 0 0
Influenza Infection R-HSA-168255 4.668818e-02 1.331 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.706752e-02 1.327 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.706752e-02 1.327 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.724735e-02 1.326 0 0
Protein ubiquitination R-HSA-8852135 4.857928e-02 1.314 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.887052e-02 1.311 0 0
Protein folding R-HSA-391251 5.012410e-02 1.300 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.035214e-02 1.298 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.035214e-02 1.298 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.064745e-02 1.295 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 5.200685e-02 1.284 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.200685e-02 1.284 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.200685e-02 1.284 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.517353e-02 1.258 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.989784e-02 1.223 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.989784e-02 1.223 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.248540e-02 1.280 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.541092e-02 1.256 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.278888e-02 1.277 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 6.014281e-02 1.221 0 0
Oncogene Induced Senescence R-HSA-2559585 6.445212e-02 1.191 0 0
Myogenesis R-HSA-525793 5.345887e-02 1.272 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.248540e-02 1.280 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.196321e-02 1.208 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.445212e-02 1.191 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.014281e-02 1.221 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.445212e-02 1.191 0 0
Autophagy R-HSA-9612973 6.165150e-02 1.210 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.884586e-02 1.230 0 0
Formation of definitive endoderm R-HSA-9823730 5.989784e-02 1.223 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.086338e-02 1.216 0 0
Interleukin-12 signaling R-HSA-9020591 5.219570e-02 1.282 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.212739e-02 1.283 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.512874e-02 1.186 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.512874e-02 1.186 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.523263e-02 1.186 0 0
Formation of annular gap junctions R-HSA-196025 6.523263e-02 1.186 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.523263e-02 1.186 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.523263e-02 1.186 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.523263e-02 1.186 0 0
MET interacts with TNS proteins R-HSA-8875513 6.580228e-02 1.182 0 0
MET activates PTPN11 R-HSA-8865999 6.580228e-02 1.182 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 6.580228e-02 1.182 0 0
Reproduction R-HSA-1474165 6.760132e-02 1.170 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.829051e-02 1.166 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.829051e-02 1.166 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.829051e-02 1.166 0 0
Nucleotide Excision Repair R-HSA-5696398 6.937409e-02 1.159 0 0
Nervous system development R-HSA-9675108 7.117120e-02 1.148 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.493326e-02 1.125 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.595296e-02 1.119 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.729959e-02 1.112 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.729959e-02 1.112 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.729959e-02 1.112 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.794210e-02 1.108 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.794210e-02 1.108 0 0
Translation initiation complex formation R-HSA-72649 7.832299e-02 1.106 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.879634e-02 1.103 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.953621e-02 1.099 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 7.979130e-02 1.098 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 7.979130e-02 1.098 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 7.979130e-02 1.098 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 7.979130e-02 1.098 0 0
ARMS-mediated activation R-HSA-170984 7.983345e-02 1.098 0 0
Lipophagy R-HSA-9613354 7.983345e-02 1.098 0 0
WNT mediated activation of DVL R-HSA-201688 7.983345e-02 1.098 0 0
Gap junction degradation R-HSA-190873 7.983345e-02 1.098 0 0
ALK mutants bind TKIs R-HSA-9700645 7.983345e-02 1.098 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.983345e-02 1.098 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.983345e-02 1.098 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.983345e-02 1.098 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.983345e-02 1.098 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.998210e-02 1.097 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.303653e-02 1.081 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.304294e-02 1.081 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.525847e-02 1.069 0 0
Hedgehog 'off' state R-HSA-5610787 8.530253e-02 1.069 1 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.543774e-02 1.068 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.543774e-02 1.068 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.543774e-02 1.068 0 0
Signaling by RAS mutants R-HSA-6802949 8.543774e-02 1.068 0 0
Regulation of gap junction activity R-HSA-191650 8.984632e-02 1.046 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 8.984632e-02 1.046 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.160023e-01 0.936 0 0
IRS activation R-HSA-74713 1.160023e-01 0.936 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.160023e-01 0.936 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 9.570952e-02 1.019 0 0
2-LTR circle formation R-HSA-164843 9.570952e-02 1.019 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.127520e-01 0.948 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 1.127520e-01 0.948 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.239660e-02 1.034 0 0
Degradation of CDH1 R-HSA-9766229 1.072577e-01 0.970 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.041658e-01 0.982 0 0
Regulation of CDH11 function R-HSA-9762292 9.570952e-02 1.019 0 0
Prolonged ERK activation events R-HSA-169893 8.761922e-02 1.057 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.006624e-01 0.997 0 0
DNA strand elongation R-HSA-69190 1.006341e-01 0.997 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.101120e-01 0.958 0 0
RNA Polymerase II Transcription R-HSA-73857 9.484900e-02 1.023 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.101120e-01 0.958 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 8.984632e-02 1.046 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 8.984632e-02 1.046 0 0
Bicarbonate transporters R-HSA-425381 1.127520e-01 0.948 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.079102e-01 0.967 0 0
Intraflagellar transport R-HSA-5620924 9.967091e-02 1.001 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.482845e-02 1.023 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.079102e-01 0.967 0 0
Neurodegenerative Diseases R-HSA-8863678 1.079102e-01 0.967 0 0
Axon guidance R-HSA-422475 1.073682e-01 0.969 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.071554e-02 1.042 0 0
NrCAM interactions R-HSA-447038 1.160023e-01 0.936 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.127520e-01 0.948 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.090096e-01 0.963 1 0
Interleukin-12 family signaling R-HSA-447115 1.100256e-01 0.959 0 0
MAP2K and MAPK activation R-HSA-5674135 1.182585e-01 0.927 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.187487e-01 0.925 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.192528e-01 0.924 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.200284e-01 0.921 0 0
Striated Muscle Contraction R-HSA-390522 1.200284e-01 0.921 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.201428e-01 0.920 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.204213e-01 0.919 0 0
Ephrin signaling R-HSA-3928664 1.273090e-01 0.895 0 0
GAB1 signalosome R-HSA-180292 1.273090e-01 0.895 0 0
Polo-like kinase mediated events R-HSA-156711 1.273090e-01 0.895 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.273090e-01 0.895 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.273090e-01 0.895 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.274125e-01 0.895 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.280904e-01 0.892 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.303703e-01 0.885 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.303703e-01 0.885 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.303703e-01 0.885 0 0
Signaling by AXIN mutants R-HSA-4839735 1.308463e-01 0.883 1 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.308463e-01 0.883 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.308463e-01 0.883 1 1
Sensing of DNA Double Strand Breaks R-HSA-5693548 1.308463e-01 0.883 0 0
Integration of provirus R-HSA-162592 1.308463e-01 0.883 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.311299e-01 0.882 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.315876e-01 0.881 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.315876e-01 0.881 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.435163e-01 0.843 1 1
IkBA variant leads to EDA-ID R-HSA-5603029 1.437806e-01 0.842 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.437806e-01 0.842 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.437806e-01 0.842 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.498750e-01 0.824 1 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.498750e-01 0.824 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.498750e-01 0.824 1 1
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.498750e-01 0.824 1 1
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.498750e-01 0.824 1 1
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.498750e-01 0.824 1 1
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.498750e-01 0.824 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.498750e-01 0.824 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.522707e-01 0.817 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.532203e-01 0.815 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.532203e-01 0.815 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.532203e-01 0.815 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.532203e-01 0.815 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.532203e-01 0.815 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.532203e-01 0.815 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.532203e-01 0.815 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.532203e-01 0.815 0 0
DAG and IP3 signaling R-HSA-1489509 1.569043e-01 0.804 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.572353e-01 0.803 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.579316e-01 0.802 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.207940e-01 0.656 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.207940e-01 0.656 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.207940e-01 0.656 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.207940e-01 0.656 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 1.727563e-01 0.763 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.025618e-01 0.693 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.025618e-01 0.693 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.025618e-01 0.693 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.025618e-01 0.693 0 0
SOS-mediated signalling R-HSA-112412 2.025618e-01 0.693 0 0
Type I hemidesmosome assembly R-HSA-446107 2.328806e-01 0.633 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.328806e-01 0.633 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 2.328806e-01 0.633 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.328806e-01 0.633 0 0
MET receptor recycling R-HSA-8875656 2.328806e-01 0.633 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.697200e-01 0.770 0 0
Formation of axial mesoderm R-HSA-9796292 1.697200e-01 0.770 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 2.113945e-01 0.675 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.113945e-01 0.675 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.113945e-01 0.675 1 1
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.894625e-01 0.722 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.637955e-01 0.786 0 0
EGFR downregulation R-HSA-182971 1.975905e-01 0.704 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.411622e-01 0.618 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.411622e-01 0.618 0 0
Deadenylation of mRNA R-HSA-429947 2.411622e-01 0.618 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.965558e-01 0.707 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.359535e-01 0.627 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.405523e-01 0.619 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.056730e-01 0.687 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.879008e-01 0.726 0 0
Activation of the pre-replicative complex R-HSA-68962 1.834533e-01 0.736 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.781426e-01 0.749 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.697077e-01 0.770 0 0
EPH-Ephrin signaling R-HSA-2682334 2.340700e-01 0.631 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.120868e-01 0.673 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.004408e-01 0.698 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.063032e-01 0.685 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.894625e-01 0.722 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.235549e-01 0.651 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.063032e-01 0.685 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.718763e-01 0.765 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.879008e-01 0.726 0 0
Developmental Cell Lineages R-HSA-9734767 2.014045e-01 0.696 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.359535e-01 0.627 0 0
Frs2-mediated activation R-HSA-170968 1.697200e-01 0.770 0 0
p75NTR signals via NF-kB R-HSA-193639 2.113945e-01 0.675 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 2.328806e-01 0.633 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.781426e-01 0.749 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.420235e-01 0.616 0 0
Ca-dependent events R-HSA-111996 2.397502e-01 0.620 0 0
Circadian clock R-HSA-9909396 1.776398e-01 0.750 0 0
Co-inhibition by PD-1 R-HSA-389948 2.141567e-01 0.669 0 0
G0 and Early G1 R-HSA-1538133 2.120868e-01 0.673 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.207940e-01 0.656 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.207940e-01 0.656 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.207940e-01 0.656 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.207940e-01 0.656 0 0
Adrenoceptors R-HSA-390696 2.328806e-01 0.633 0 0
Trafficking of AMPA receptors R-HSA-399719 1.975905e-01 0.704 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.056874e-01 0.687 0 0
rRNA processing R-HSA-72312 2.132534e-01 0.671 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.132772e-01 0.671 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.902646e-01 0.721 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.834533e-01 0.736 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.637955e-01 0.786 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.661572e-01 0.779 0 0
Signaling by NOTCH R-HSA-157118 1.969863e-01 0.706 0 0
Negative regulation of FLT3 R-HSA-9706369 2.329996e-01 0.633 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.025618e-01 0.693 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.264028e-01 0.645 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.157303e-01 0.666 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.425578e-01 0.615 0 0
Signaling by NTRKs R-HSA-166520 2.263404e-01 0.645 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.207940e-01 0.656 0 0
TGFBR3 PTM regulation R-HSA-9839383 2.328806e-01 0.633 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.063032e-01 0.685 0 0
Basigin interactions R-HSA-210991 1.730882e-01 0.762 0 0
Diseases of DNA repair R-HSA-9675135 1.673742e-01 0.776 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.025618e-01 0.693 0 0
Sodium/Proton exchangers R-HSA-425986 2.328806e-01 0.633 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.894625e-01 0.722 0 0
Signaling by Hedgehog R-HSA-5358351 2.257321e-01 0.646 1 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.269090e-01 0.644 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.025618e-01 0.693 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.025618e-01 0.693 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.359535e-01 0.627 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.329996e-01 0.633 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.736595e-01 0.760 0 0
MHC class II antigen presentation R-HSA-2132295 1.750580e-01 0.757 0 0
SARS-CoV Infections R-HSA-9679506 2.451218e-01 0.611 1 0
IRE1alpha activates chaperones R-HSA-381070 2.249752e-01 0.648 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.958098e-01 0.708 0 0
SLC transporter disorders R-HSA-5619102 2.074436e-01 0.683 0 0
tRNA processing R-HSA-72306 2.334137e-01 0.632 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.471852e-01 0.607 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.481993e-01 0.605 0 0
Developmental Biology R-HSA-1266738 2.541468e-01 0.595 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.549744e-01 0.594 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.549744e-01 0.594 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.549744e-01 0.594 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 2.829790e-01 0.548 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.829790e-01 0.548 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.829790e-01 0.548 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.829790e-01 0.548 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.829790e-01 0.548 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 3.402047e-01 0.468 0 0
PLC-gamma1 signalling R-HSA-167021 3.402047e-01 0.468 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.402047e-01 0.468 0 0
Invadopodia formation R-HSA-8941237 3.402047e-01 0.468 0 0
Calcineurin activates NFAT R-HSA-2025928 2.634412e-01 0.579 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 3.928663e-01 0.406 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 3.928663e-01 0.406 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 3.928663e-01 0.406 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 3.928663e-01 0.406 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.928663e-01 0.406 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.928663e-01 0.406 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 3.928663e-01 0.406 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.940122e-01 0.532 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.940122e-01 0.532 0 0
PECAM1 interactions R-HSA-210990 3.243975e-01 0.489 0 0
Signaling by APC mutants R-HSA-4839744 3.243975e-01 0.489 1 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.243975e-01 0.489 1 1
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.243975e-01 0.489 1 1
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.243975e-01 0.489 1 1
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.413276e-01 0.355 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.413276e-01 0.355 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.413276e-01 0.355 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.413276e-01 0.355 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.544322e-01 0.450 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.544322e-01 0.450 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.544322e-01 0.450 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.996386e-01 0.523 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 3.221460e-01 0.492 0 0
MET activates RAS signaling R-HSA-8851805 3.839789e-01 0.416 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.839789e-01 0.416 0 0
Repression of WNT target genes R-HSA-4641265 3.839789e-01 0.416 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.839789e-01 0.416 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 4.859234e-01 0.313 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 4.859234e-01 0.313 0 0
Phosphorylation of Emi1 R-HSA-176417 4.859234e-01 0.313 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.859234e-01 0.313 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.859234e-01 0.313 0 0
Signaling by MAPK mutants R-HSA-9652817 4.859234e-01 0.313 0 0
RAF activation R-HSA-5673000 2.573965e-01 0.589 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 3.446595e-01 0.463 0 0
Negative regulation of MET activity R-HSA-6807004 3.446595e-01 0.463 0 0
Signaling by Erythropoietin R-HSA-9006335 3.326648e-01 0.478 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.894105e-01 0.410 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.894105e-01 0.410 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.894105e-01 0.410 0 0
FGFR2 alternative splicing R-HSA-6803529 4.115170e-01 0.386 0 0
Erythropoietin activates RAS R-HSA-9027284 4.686605e-01 0.329 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.686605e-01 0.329 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.686605e-01 0.329 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.686605e-01 0.329 0 0
G beta:gamma signalling through BTK R-HSA-8964315 4.686605e-01 0.329 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.333672e-01 0.363 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.821287e-01 0.418 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.549107e-01 0.342 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.953204e-01 0.305 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.967446e-01 0.401 0 0
Dual Incision in GG-NER R-HSA-5696400 4.437759e-01 0.353 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.933796e-01 0.405 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.502993e-01 0.346 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.502993e-01 0.346 0 0
Nucleosome assembly R-HSA-774815 4.502993e-01 0.346 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.502993e-01 0.346 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.404174e-01 0.356 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.797416e-01 0.319 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.661954e-01 0.331 0 0
Post-translational protein phosphorylation R-HSA-8957275 4.209975e-01 0.376 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.692031e-01 0.329 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.975689e-01 0.303 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.249945e-01 0.488 1 1
Signaling by NOTCH2 R-HSA-1980145 4.437759e-01 0.353 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.416275e-01 0.466 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.887833e-01 0.539 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.531994e-01 0.452 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.531994e-01 0.452 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.671039e-01 0.435 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.513055e-01 0.454 0 0
Adipogenesis R-HSA-9843745 3.418654e-01 0.466 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.772187e-01 0.557 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.129241e-01 0.384 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.865944e-01 0.413 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.544322e-01 0.450 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.411759e-01 0.355 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.372052e-01 0.472 0 0
Nephrin family interactions R-HSA-373753 3.446595e-01 0.463 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.761029e-01 0.322 0 0
PI3K/AKT activation R-HSA-198203 2.940122e-01 0.532 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.115170e-01 0.386 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.782159e-01 0.422 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 3.865944e-01 0.413 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.648534e-01 0.438 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.130713e-01 0.290 1 0
EPHB-mediated forward signaling R-HSA-3928662 2.671376e-01 0.573 0 0
NF-kB is activated and signals survival R-HSA-209560 3.544322e-01 0.450 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.975414e-01 0.303 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.502993e-01 0.346 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.221460e-01 0.492 0 0
UCH proteinases R-HSA-5689603 3.990129e-01 0.399 0 0
Transferrin endocytosis and recycling R-HSA-917977 4.618638e-01 0.335 0 0
RNA Polymerase III Transcription R-HSA-74158 4.797416e-01 0.319 0 0
Long-term potentiation R-HSA-9620244 4.761029e-01 0.322 0 0
Degradation of DVL R-HSA-4641258 4.973823e-01 0.303 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.953204e-01 0.305 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.797416e-01 0.319 0 0
Neurexins and neuroligins R-HSA-6794361 3.821287e-01 0.418 0 0
mRNA Editing R-HSA-75072 2.634412e-01 0.579 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.928663e-01 0.406 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.413276e-01 0.355 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.411759e-01 0.355 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.953204e-01 0.305 0 0
Killing mechanisms R-HSA-9664420 4.953204e-01 0.305 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.548548e-01 0.342 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.142302e-01 0.383 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.194036e-01 0.496 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.723229e-01 0.565 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.194036e-01 0.496 0 0
Signaling by ERBB2 R-HSA-1227986 3.382504e-01 0.471 0 0
Signaling by WNT in cancer R-HSA-4791275 3.885590e-01 0.411 1 0
Generic Transcription Pathway R-HSA-212436 3.289685e-01 0.483 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.618638e-01 0.335 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.928663e-01 0.406 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.928663e-01 0.406 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.859234e-01 0.313 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 4.859234e-01 0.313 0 0
HDACs deacetylate histones R-HSA-3214815 2.732414e-01 0.563 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.834463e-01 0.316 0 0
Synthesis of DNA R-HSA-69239 4.037909e-01 0.394 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.583405e-01 0.446 0 0
Calmodulin induced events R-HSA-111933 2.887833e-01 0.539 0 0
PLC beta mediated events R-HSA-112043 3.515260e-01 0.454 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.634412e-01 0.579 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.839789e-01 0.416 0 0
PTEN Regulation R-HSA-6807070 3.214752e-01 0.493 0 0
CaM pathway R-HSA-111997 2.887833e-01 0.539 0 0
Mismatch Repair R-HSA-5358508 2.996386e-01 0.523 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.865468e-01 0.313 0 0
Opioid Signalling R-HSA-111885 4.865468e-01 0.313 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.829790e-01 0.548 0 0
Signalling to ERK5 R-HSA-198765 2.829790e-01 0.548 0 0
MET activates STAT3 R-HSA-8875791 3.402047e-01 0.468 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.634412e-01 0.579 0 0
GABA synthesis R-HSA-888568 3.928663e-01 0.406 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.243975e-01 0.489 0 0
vRNP Assembly R-HSA-192905 3.243975e-01 0.489 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.413276e-01 0.355 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.544322e-01 0.450 1 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.129241e-01 0.384 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.369698e-01 0.472 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.531994e-01 0.452 0 0
Diseases of Immune System R-HSA-5260271 3.531994e-01 0.452 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.686605e-01 0.329 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.686605e-01 0.329 0 0
Orc1 removal from chromatin R-HSA-68949 3.821287e-01 0.418 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.255073e-01 0.371 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 4.953204e-01 0.305 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.618170e-01 0.442 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.812482e-01 0.551 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.969047e-01 0.304 0 0
Signaling by PTK6 R-HSA-8848021 3.782159e-01 0.422 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.782159e-01 0.422 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.857284e-01 0.414 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.819484e-01 0.317 0 0
Signalling to ERKs R-HSA-187687 4.618638e-01 0.335 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.686605e-01 0.329 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.549107e-01 0.342 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.155416e-01 0.501 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 2.634412e-01 0.579 0 0
Ca2+ pathway R-HSA-4086398 5.104419e-01 0.292 0 0
Signaling by VEGF R-HSA-194138 3.829071e-01 0.417 0 0
G-protein mediated events R-HSA-112040 4.317013e-01 0.365 0 0
Signal attenuation R-HSA-74749 2.940122e-01 0.532 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.996386e-01 0.523 0 0
Rap1 signalling R-HSA-392517 3.221460e-01 0.492 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.446595e-01 0.463 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.070902e-01 0.390 0 0
TBC/RABGAPs R-HSA-8854214 4.181640e-01 0.379 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.064678e-01 0.514 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.412497e-01 0.467 0 0
HDMs demethylate histones R-HSA-3214842 2.590707e-01 0.587 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.648534e-01 0.438 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 3.928663e-01 0.406 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.413276e-01 0.355 0 0
Pervasive developmental disorders R-HSA-9005895 3.839789e-01 0.416 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.839789e-01 0.416 0 0
Disorders of Nervous System Development R-HSA-9697154 3.839789e-01 0.416 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.411759e-01 0.355 0 0
Rab regulation of trafficking R-HSA-9007101 4.079018e-01 0.389 0 0
Ub-specific processing proteases R-HSA-5689880 4.305653e-01 0.366 0 0
MAPK family signaling cascades R-HSA-5683057 4.895654e-01 0.310 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.676033e-01 0.330 0 0
NGF-stimulated transcription R-HSA-9031628 4.975385e-01 0.303 0 0
Transmission across Chemical Synapses R-HSA-112315 4.895017e-01 0.310 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.953204e-01 0.305 0 0
Iron uptake and transport R-HSA-917937 3.865944e-01 0.413 0 0
DNA Damage Bypass R-HSA-73893 3.383860e-01 0.471 0 0
Diseases of programmed cell death R-HSA-9645723 2.912145e-01 0.536 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.857284e-01 0.414 0 0
Interleukin-1 signaling R-HSA-9020702 4.539069e-01 0.343 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.402047e-01 0.468 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.634412e-01 0.579 0 0
NADE modulates death signalling R-HSA-205025 3.928663e-01 0.406 0 0
Josephin domain DUBs R-HSA-5689877 2.940122e-01 0.532 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.772266e-01 0.557 0 0
The NLRP3 inflammasome R-HSA-844456 3.221460e-01 0.492 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.859234e-01 0.313 0 0
Signaling by NODAL R-HSA-1181150 3.446595e-01 0.463 0 0
Creatine metabolism R-HSA-71288 3.446595e-01 0.463 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.686605e-01 0.329 0 0
Metalloprotease DUBs R-HSA-5689901 4.969047e-01 0.304 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.661954e-01 0.331 0 0
HATs acetylate histones R-HSA-3214847 4.319841e-01 0.365 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.701529e-01 0.432 0 0
HCMV Late Events R-HSA-9610379 3.858349e-01 0.414 0 0
Smooth Muscle Contraction R-HSA-445355 3.967446e-01 0.401 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.972461e-01 0.303 0 0
Suppression of apoptosis R-HSA-9635465 3.243975e-01 0.489 0 0
Semaphorin interactions R-HSA-373755 3.782159e-01 0.422 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.821287e-01 0.418 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.634412e-01 0.579 0 0
Transmission across Electrical Synapses R-HSA-112307 3.928663e-01 0.406 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 3.928663e-01 0.406 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 2.940122e-01 0.532 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.544322e-01 0.450 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.996386e-01 0.523 0 0
Regulation of KIT signaling R-HSA-1433559 4.411759e-01 0.355 0 0
Signaling by NOTCH4 R-HSA-9013694 3.741915e-01 0.427 0 0
Biotin transport and metabolism R-HSA-196780 4.686605e-01 0.329 0 0
Viral Infection Pathways R-HSA-9824446 4.500364e-01 0.347 1 0
Protein methylation R-HSA-8876725 4.686605e-01 0.329 0 0
Expression and Processing of Neurotrophins R-HSA-9036866 3.402047e-01 0.468 0 0
NGF processing R-HSA-167060 3.402047e-01 0.468 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.634412e-01 0.579 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.634412e-01 0.579 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.859234e-01 0.313 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.671039e-01 0.435 0 0
Signal regulatory protein family interactions R-HSA-391160 4.411759e-01 0.355 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.070902e-01 0.390 0 0
Signaling by NOTCH3 R-HSA-9012852 4.259079e-01 0.371 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.578117e-01 0.589 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.181640e-01 0.379 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.859234e-01 0.313 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.239111e-01 0.490 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 4.115170e-01 0.386 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.969047e-01 0.304 0 0
Cardiogenesis R-HSA-9733709 4.070902e-01 0.390 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.661954e-01 0.331 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.413276e-01 0.355 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.544322e-01 0.450 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 4.859234e-01 0.313 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.450060e-01 0.352 0 0
OAS antiviral response R-HSA-8983711 3.839789e-01 0.416 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.085068e-01 0.511 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.860032e-01 0.544 0 0
Disorders of transmembrane transporters R-HSA-5619115 4.608465e-01 0.336 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.671039e-01 0.435 0 0
Signaling by Interleukins R-HSA-449147 3.942074e-01 0.404 0 0
Signaling by Leptin R-HSA-2586552 2.940122e-01 0.532 0 0
Synthesis and processing of ENV and VPU R-HSA-171286 2.829790e-01 0.548 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.369698e-01 0.472 0 0
Interleukin-7 signaling R-HSA-1266695 4.761029e-01 0.322 0 0
Interleukin-37 signaling R-HSA-9008059 3.513055e-01 0.454 0 0
MET promotes cell motility R-HSA-8875878 5.147614e-01 0.288 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.150096e-01 0.288 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.172821e-01 0.286 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.172821e-01 0.286 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.172821e-01 0.286 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.211123e-01 0.283 0 0
Disorders of Developmental Biology R-HSA-9675151 5.211123e-01 0.283 0 0
Synthesis of PG R-HSA-1483148 5.211123e-01 0.283 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.211123e-01 0.283 0 0
Heme signaling R-HSA-9707616 5.253959e-01 0.280 0 0
Signaling by PDGF R-HSA-186797 5.253959e-01 0.280 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.269618e-01 0.278 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.269618e-01 0.278 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.269618e-01 0.278 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.269618e-01 0.278 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 5.269618e-01 0.278 0 0
MET Receptor Activation R-HSA-6806942 5.269618e-01 0.278 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 5.269618e-01 0.278 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.269618e-01 0.278 0 0
Abacavir transmembrane transport R-HSA-2161517 5.269618e-01 0.278 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.269618e-01 0.278 0 0
HDL clearance R-HSA-8964011 5.269618e-01 0.278 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.269618e-01 0.278 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.311377e-01 0.275 0 0
Stabilization of p53 R-HSA-69541 5.318568e-01 0.274 0 0
HIV elongation arrest and recovery R-HSA-167287 5.372057e-01 0.270 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.372057e-01 0.270 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.372057e-01 0.270 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.372057e-01 0.270 0 0
Insulin receptor recycling R-HSA-77387 5.372057e-01 0.270 0 0
Inflammasomes R-HSA-622312 5.372057e-01 0.270 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.390741e-01 0.268 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.398070e-01 0.268 0 0
Meiotic recombination R-HSA-912446 5.431543e-01 0.265 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.460048e-01 0.263 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.460048e-01 0.263 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.460048e-01 0.263 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.460048e-01 0.263 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.460048e-01 0.263 0 0
Specification of primordial germ cells R-HSA-9827857 5.460048e-01 0.263 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.476861e-01 0.261 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.476861e-01 0.261 0 0
Generation of second messenger molecules R-HSA-202433 5.486486e-01 0.261 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.486486e-01 0.261 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.486486e-01 0.261 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.502281e-01 0.259 0 0
Interleukin-1 family signaling R-HSA-446652 5.505141e-01 0.259 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.531684e-01 0.257 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.531684e-01 0.257 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.531684e-01 0.257 0 0
Late endosomal microautophagy R-HSA-9615710 5.566508e-01 0.254 0 0
DARPP-32 events R-HSA-180024 5.566508e-01 0.254 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.566508e-01 0.254 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.566508e-01 0.254 0 0
TCR signaling R-HSA-202403 5.605582e-01 0.251 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 5.647264e-01 0.248 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.647264e-01 0.248 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 5.647264e-01 0.248 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 5.647264e-01 0.248 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 5.647264e-01 0.248 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.647264e-01 0.248 0 0
Recycling of eIF2:GDP R-HSA-72731 5.647264e-01 0.248 0 0
PTK6 Expression R-HSA-8849473 5.647264e-01 0.248 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 5.647264e-01 0.248 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 5.647264e-01 0.248 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.647264e-01 0.248 0 0
VLDL clearance R-HSA-8964046 5.647264e-01 0.248 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 5.647264e-01 0.248 0 0
Regulation of PTEN localization R-HSA-8948747 5.647264e-01 0.248 0 0
CHL1 interactions R-HSA-447041 5.647264e-01 0.248 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.647264e-01 0.248 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.651192e-01 0.248 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.651192e-01 0.248 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.651192e-01 0.248 0 0
FLT3 Signaling R-HSA-9607240 5.651192e-01 0.248 0 0
Chromosome Maintenance R-HSA-73886 5.673468e-01 0.246 0 0
ER-Phagosome pathway R-HSA-1236974 5.681055e-01 0.246 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.699772e-01 0.244 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.699772e-01 0.244 0 0
Platelet sensitization by LDL R-HSA-432142 5.699772e-01 0.244 0 0
Neutrophil degranulation R-HSA-6798695 5.699799e-01 0.244 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.724492e-01 0.242 0 0
Amino acids regulate mTORC1 R-HSA-9639288 5.724492e-01 0.242 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.755971e-01 0.240 0 0
DAP12 signaling R-HSA-2424491 5.755971e-01 0.240 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.755971e-01 0.240 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.755971e-01 0.240 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.770466e-01 0.239 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.770466e-01 0.239 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.812534e-01 0.236 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.812534e-01 0.236 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.812534e-01 0.236 0 0
Sensory processing of sound R-HSA-9659379 5.850570e-01 0.233 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.906555e-01 0.229 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.909485e-01 0.228 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.909485e-01 0.228 0 0
Regulation of signaling by CBL R-HSA-912631 5.930177e-01 0.227 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.930177e-01 0.227 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.930177e-01 0.227 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.930177e-01 0.227 0 0
Specification of the neural plate border R-HSA-9834899 5.930177e-01 0.227 0 0
Maturation of nucleoprotein R-HSA-9694631 5.930177e-01 0.227 1 1
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 5.940279e-01 0.226 0 0
Downstream signal transduction R-HSA-186763 5.940279e-01 0.226 0 0
Signaling by MET R-HSA-6806834 5.969448e-01 0.224 0 0
Signaling by FGFR2 R-HSA-5654738 5.969448e-01 0.224 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.970376e-01 0.224 0 0
phospho-PLA2 pathway R-HSA-111995 5.994781e-01 0.222 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 5.994781e-01 0.222 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.994781e-01 0.222 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 5.994781e-01 0.222 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.994781e-01 0.222 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 5.994781e-01 0.222 0 0
Alpha-defensins R-HSA-1462054 5.994781e-01 0.222 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.994781e-01 0.222 0 0
Transcription of the HIV genome R-HSA-167172 6.046662e-01 0.218 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.057856e-01 0.218 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.079920e-01 0.216 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.106600e-01 0.214 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.119301e-01 0.213 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.124605e-01 0.213 0 0
Signaling by FGFR4 R-HSA-5654743 6.124605e-01 0.213 0 0
TNF signaling R-HSA-75893 6.144699e-01 0.211 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.151223e-01 0.211 0 0
Signal transduction by L1 R-HSA-445144 6.151223e-01 0.211 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.189352e-01 0.208 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.233678e-01 0.205 0 0
Nuclear RNA decay R-HSA-9930044 6.292943e-01 0.201 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.292943e-01 0.201 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.292943e-01 0.201 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.294285e-01 0.201 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 6.314572e-01 0.200 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.314572e-01 0.200 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 6.314572e-01 0.200 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.314572e-01 0.200 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.314572e-01 0.200 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.314572e-01 0.200 0 0
Interleukin-1 processing R-HSA-448706 6.314572e-01 0.200 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.314572e-01 0.200 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.314572e-01 0.200 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.314572e-01 0.200 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.362936e-01 0.196 0 0
Lagging Strand Synthesis R-HSA-69186 6.362936e-01 0.196 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.362936e-01 0.196 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.362936e-01 0.196 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.362936e-01 0.196 0 0
Potential therapeutics for SARS R-HSA-9679191 6.395622e-01 0.194 0 0
Dual incision in TC-NER R-HSA-6782135 6.410940e-01 0.193 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.410940e-01 0.193 0 0
Hedgehog 'on' state R-HSA-5632684 6.414649e-01 0.193 1 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.421861e-01 0.192 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 6.421861e-01 0.192 0 0
Signaling by FGFR3 R-HSA-5654741 6.421861e-01 0.192 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.449404e-01 0.190 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.461137e-01 0.190 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.532642e-01 0.185 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.532642e-01 0.185 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.564748e-01 0.183 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.565396e-01 0.183 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.565396e-01 0.183 0 0
Attachment and Entry R-HSA-9694614 6.565396e-01 0.183 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.565396e-01 0.183 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.565396e-01 0.183 0 0
Serine metabolism R-HSA-977347 6.565396e-01 0.183 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.593892e-01 0.181 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.608848e-01 0.180 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.608848e-01 0.180 0 0
Binding and entry of HIV virion R-HSA-173107 6.608848e-01 0.180 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.608848e-01 0.180 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.608848e-01 0.180 0 0
DNA replication initiation R-HSA-68952 6.608848e-01 0.180 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.608848e-01 0.180 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.608848e-01 0.180 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.608848e-01 0.180 0 0
Pexophagy R-HSA-9664873 6.608848e-01 0.180 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 6.608848e-01 0.180 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.623844e-01 0.179 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.623844e-01 0.179 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.623844e-01 0.179 0 0
Mitophagy R-HSA-5205647 6.623844e-01 0.179 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.643581e-01 0.178 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.643581e-01 0.178 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.665436e-01 0.176 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.749181e-01 0.171 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.758732e-01 0.170 0 0
Notch-HLH transcription pathway R-HSA-350054 6.758732e-01 0.170 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.758732e-01 0.170 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.758732e-01 0.170 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.758732e-01 0.170 0 0
Signaling by FGFR in disease R-HSA-1226099 6.761342e-01 0.170 0 0
Signaling by ERBB4 R-HSA-1236394 6.761342e-01 0.170 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.781051e-01 0.169 0 0
MAP kinase activation R-HSA-450294 6.788163e-01 0.168 0 0
Metal ion SLC transporters R-HSA-425410 6.838815e-01 0.165 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.879642e-01 0.162 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 6.879642e-01 0.162 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.879642e-01 0.162 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.879642e-01 0.162 0 0
Transport of RCbl within the body R-HSA-9758890 6.879642e-01 0.162 0 0
Dissolution of Fibrin Clot R-HSA-75205 6.879642e-01 0.162 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.907833e-01 0.161 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.923220e-01 0.160 0 0
RET signaling R-HSA-8853659 6.932766e-01 0.159 0 0
FLT3 signaling in disease R-HSA-9682385 6.932766e-01 0.159 0 0
FOXO-mediated transcription R-HSA-9614085 6.938402e-01 0.159 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.943109e-01 0.158 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.943109e-01 0.158 0 0
Carnitine shuttle R-HSA-200425 6.943109e-01 0.158 0 0
Syndecan interactions R-HSA-3000170 6.943109e-01 0.158 0 0
Growth hormone receptor signaling R-HSA-982772 6.943109e-01 0.158 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.969944e-01 0.157 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.969944e-01 0.157 0 0
Signaling by NOTCH1 R-HSA-1980143 6.980102e-01 0.156 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.000429e-01 0.155 0 0
Post-translational protein modification R-HSA-597592 7.073518e-01 0.150 0 0
Degradation of AXIN R-HSA-4641257 7.079020e-01 0.150 0 0
Signaling by WNT R-HSA-195721 7.111395e-01 0.148 1 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.118725e-01 0.148 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.123499e-01 0.147 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.128827e-01 0.147 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.128827e-01 0.147 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.128827e-01 0.147 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.137926e-01 0.146 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.219857e-01 0.141 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.220368e-01 0.141 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.220368e-01 0.141 0 0
Cellular response to hypoxia R-HSA-1234174 7.248332e-01 0.140 0 0
G1/S Transition R-HSA-69206 7.259664e-01 0.139 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.285803e-01 0.138 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.285803e-01 0.138 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.285803e-01 0.138 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.285803e-01 0.138 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.289240e-01 0.137 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.308915e-01 0.136 0 0
Gastrulation R-HSA-9758941 7.315626e-01 0.136 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.324465e-01 0.135 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.339686e-01 0.134 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.358126e-01 0.133 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.358126e-01 0.133 0 0
Regulation of IFNG signaling R-HSA-877312 7.358126e-01 0.133 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.358126e-01 0.133 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.358126e-01 0.133 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 7.358126e-01 0.133 0 0
Signaling by LTK R-HSA-9842663 7.358126e-01 0.133 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.358126e-01 0.133 0 0
Leading Strand Synthesis R-HSA-69109 7.358126e-01 0.133 0 0
Polymerase switching R-HSA-69091 7.358126e-01 0.133 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.358126e-01 0.133 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.358126e-01 0.133 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.358126e-01 0.133 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.387181e-01 0.132 0 0
Platelet degranulation R-HSA-114608 7.415348e-01 0.130 0 0
Neuronal System R-HSA-112316 7.417356e-01 0.130 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.444586e-01 0.128 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.444586e-01 0.128 0 0
TRP channels R-HSA-3295583 7.444586e-01 0.128 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.444586e-01 0.128 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.455107e-01 0.128 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.482569e-01 0.126 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.485551e-01 0.126 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.485551e-01 0.126 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.485551e-01 0.126 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.485551e-01 0.126 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.561028e-01 0.121 0 0
Toll-like Receptor Cascades R-HSA-168898 7.562477e-01 0.121 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.566665e-01 0.121 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.569126e-01 0.121 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.569126e-01 0.121 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.569126e-01 0.121 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.569126e-01 0.121 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.569126e-01 0.121 0 0
Processing of SMDT1 R-HSA-8949664 7.569126e-01 0.121 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.569126e-01 0.121 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.569126e-01 0.121 0 0
Maturation of nucleoprotein R-HSA-9683610 7.569126e-01 0.121 0 0
Interleukin-6 signaling R-HSA-1059683 7.569126e-01 0.121 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.569126e-01 0.121 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.586034e-01 0.120 0 0
Mitochondrial biogenesis R-HSA-1592230 7.594494e-01 0.120 0 0
Cristae formation R-HSA-8949613 7.595333e-01 0.119 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.595333e-01 0.119 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.595333e-01 0.119 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.595333e-01 0.119 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.610573e-01 0.119 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.610573e-01 0.119 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.660217e-01 0.116 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.665717e-01 0.115 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.730508e-01 0.112 0 0
HIV Transcription Initiation R-HSA-167161 7.730508e-01 0.112 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.730508e-01 0.112 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.730508e-01 0.112 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.738315e-01 0.111 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.738315e-01 0.111 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.754224e-01 0.110 0 0
Interleukin-17 signaling R-HSA-448424 7.754224e-01 0.110 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.754224e-01 0.110 0 0
Removal of the Flap Intermediate R-HSA-69166 7.763285e-01 0.110 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.763285e-01 0.110 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.763285e-01 0.110 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.763285e-01 0.110 0 0
Hydrolysis of LPC R-HSA-1483115 7.763285e-01 0.110 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.763285e-01 0.110 0 0
Physiological factors R-HSA-5578768 7.763285e-01 0.110 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.763285e-01 0.110 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.763285e-01 0.110 0 0
Zinc transporters R-HSA-435354 7.763285e-01 0.110 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.763285e-01 0.110 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.766599e-01 0.110 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.766599e-01 0.110 0 0
Signaling by FGFR1 R-HSA-5654736 7.778375e-01 0.109 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.788247e-01 0.109 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.845465e-01 0.105 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.845465e-01 0.105 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.846119e-01 0.105 0 0
mRNA Capping R-HSA-72086 7.873811e-01 0.104 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.873811e-01 0.104 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.873811e-01 0.104 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.873811e-01 0.104 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.885594e-01 0.103 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.912394e-01 0.102 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.941947e-01 0.100 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.941947e-01 0.100 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.941947e-01 0.100 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.941947e-01 0.100 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.941947e-01 0.100 0 0
DCC mediated attractive signaling R-HSA-418885 7.941947e-01 0.100 0 0
DNA Damage Reversal R-HSA-73942 7.941947e-01 0.100 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.955559e-01 0.099 0 0
Defective pyroptosis R-HSA-9710421 7.955559e-01 0.099 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.955559e-01 0.099 0 0
Signaling by SCF-KIT R-HSA-1433557 7.955559e-01 0.099 0 0
Signaling by FGFR R-HSA-190236 7.998776e-01 0.097 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.002102e-01 0.097 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.002102e-01 0.097 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.002102e-01 0.097 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.002102e-01 0.097 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.002102e-01 0.097 0 0
Muscle contraction R-HSA-397014 8.054750e-01 0.094 0 0
DAP12 interactions R-HSA-2172127 8.060913e-01 0.094 0 0
Amine ligand-binding receptors R-HSA-375280 8.060913e-01 0.094 0 0
RMTs methylate histone arginines R-HSA-3214858 8.060913e-01 0.094 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.060913e-01 0.094 0 0
Extension of Telomeres R-HSA-180786 8.068270e-01 0.093 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.106348e-01 0.091 0 0
Phosphorylation of the APC/C R-HSA-176412 8.106348e-01 0.091 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.106348e-01 0.091 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.106348e-01 0.091 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.106348e-01 0.091 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.106348e-01 0.091 0 0
Activation of SMO R-HSA-5635838 8.106348e-01 0.091 1 1
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.106348e-01 0.091 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.106348e-01 0.091 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.106348e-01 0.091 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.106348e-01 0.091 0 0
Attachment and Entry R-HSA-9678110 8.106348e-01 0.091 0 0
Atorvastatin ADME R-HSA-9754706 8.106348e-01 0.091 0 0
Differentiation of T cells R-HSA-9945266 8.106348e-01 0.091 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.106348e-01 0.091 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.123476e-01 0.090 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.123476e-01 0.090 0 0
Cargo concentration in the ER R-HSA-5694530 8.123476e-01 0.090 0 0
ABC-family proteins mediated transport R-HSA-382556 8.143054e-01 0.089 0 0
Adaptive Immune System R-HSA-1280218 8.161479e-01 0.088 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.161655e-01 0.088 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.161655e-01 0.088 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.161655e-01 0.088 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.161655e-01 0.088 0 0
Somitogenesis R-HSA-9824272 8.161655e-01 0.088 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.238219e-01 0.084 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.238219e-01 0.084 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.243866e-01 0.084 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.257625e-01 0.083 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.257625e-01 0.083 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.257625e-01 0.083 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.257625e-01 0.083 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.257625e-01 0.083 0 0
Passive transport by Aquaporins R-HSA-432047 8.257625e-01 0.083 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.257625e-01 0.083 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.257625e-01 0.083 0 0
Coenzyme A biosynthesis R-HSA-196783 8.257625e-01 0.083 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.257915e-01 0.083 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.257915e-01 0.083 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.291814e-01 0.081 0 0
Base Excision Repair R-HSA-73884 8.299442e-01 0.081 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.326589e-01 0.080 0 0
Mitochondrial protein import R-HSA-1268020 8.326589e-01 0.080 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.338350e-01 0.079 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.345480e-01 0.079 0 0
G-protein beta:gamma signalling R-HSA-397795 8.346615e-01 0.078 0 0
Integrin signaling R-HSA-354192 8.346615e-01 0.078 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.346615e-01 0.078 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.346615e-01 0.078 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.349830e-01 0.078 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.396825e-01 0.076 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.396825e-01 0.076 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.396825e-01 0.076 0 0
Glycogen storage diseases R-HSA-3229121 8.396825e-01 0.076 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.396825e-01 0.076 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.396825e-01 0.076 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.396825e-01 0.076 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.396825e-01 0.076 0 0
Protein localization R-HSA-9609507 8.397846e-01 0.076 0 0
DNA Replication R-HSA-69306 8.397846e-01 0.076 0 0
PCP/CE pathway R-HSA-4086400 8.410710e-01 0.075 0 0
Integrin cell surface interactions R-HSA-216083 8.410710e-01 0.075 0 0
Gluconeogenesis R-HSA-70263 8.437534e-01 0.074 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.444036e-01 0.073 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.448945e-01 0.073 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.448945e-01 0.073 0 0
Heme degradation R-HSA-189483 8.448945e-01 0.073 0 0
IGF1R signaling cascade R-HSA-2428924 8.482292e-01 0.071 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.498451e-01 0.071 0 0
Signaling by Insulin receptor R-HSA-74752 8.498451e-01 0.071 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.521167e-01 0.070 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.524913e-01 0.069 0 0
PKA activation R-HSA-163615 8.524913e-01 0.069 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.524913e-01 0.069 0 0
PKA activation in glucagon signalling R-HSA-164378 8.524913e-01 0.069 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.524913e-01 0.069 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.524913e-01 0.069 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.524913e-01 0.069 0 0
Apoptotic factor-mediated response R-HSA-111471 8.524913e-01 0.069 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.524913e-01 0.069 0 0
Signal amplification R-HSA-392518 8.545487e-01 0.068 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.545487e-01 0.068 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.545487e-01 0.068 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.545487e-01 0.068 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.545487e-01 0.068 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.545487e-01 0.068 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.545487e-01 0.068 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.545487e-01 0.068 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.545487e-01 0.068 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.555439e-01 0.068 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.600867e-01 0.065 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.600867e-01 0.065 0 0
PI3K Cascade R-HSA-109704 8.600867e-01 0.065 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.616554e-01 0.065 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.620249e-01 0.064 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.636512e-01 0.064 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.636512e-01 0.064 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.636512e-01 0.064 0 0
Regulation of Apoptosis R-HSA-169911 8.636512e-01 0.064 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.640532e-01 0.063 0 0
Cellular response to starvation R-HSA-9711097 8.640675e-01 0.063 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.642773e-01 0.063 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.642773e-01 0.063 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.642773e-01 0.063 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.642773e-01 0.063 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.642773e-01 0.063 0 0
Translesion Synthesis by POLH R-HSA-110320 8.642773e-01 0.063 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.642773e-01 0.063 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.642773e-01 0.063 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.642773e-01 0.063 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.676773e-01 0.062 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.678018e-01 0.062 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.722285e-01 0.059 0 0
RUNX2 regulates bone development R-HSA-8941326 8.722285e-01 0.059 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.722285e-01 0.059 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.722285e-01 0.059 0 0
GPVI-mediated activation cascade R-HSA-114604 8.722285e-01 0.059 0 0
G1/S-Specific Transcription R-HSA-69205 8.722285e-01 0.059 0 0
Immune System R-HSA-168256 8.726096e-01 0.059 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.749022e-01 0.058 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.751223e-01 0.058 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.751223e-01 0.058 0 0
Glycogen synthesis R-HSA-3322077 8.751223e-01 0.058 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.751223e-01 0.058 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.751223e-01 0.058 0 0
Pregnenolone biosynthesis R-HSA-196108 8.751223e-01 0.058 0 0
Protein hydroxylation R-HSA-9629569 8.751223e-01 0.058 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.803063e-01 0.055 0 0
Signaling by ROBO receptors R-HSA-376176 8.810422e-01 0.055 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.817752e-01 0.055 0 0
Telomere Maintenance R-HSA-157579 8.839354e-01 0.054 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.851013e-01 0.053 0 0
G-protein activation R-HSA-202040 8.851013e-01 0.053 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.851013e-01 0.053 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.851013e-01 0.053 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.851013e-01 0.053 0 0
ERK/MAPK targets R-HSA-198753 8.851013e-01 0.053 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.851013e-01 0.053 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 8.851013e-01 0.053 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.851013e-01 0.053 0 0
COPII-mediated vesicle transport R-HSA-204005 8.877605e-01 0.052 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.879098e-01 0.052 0 0
Elastic fibre formation R-HSA-1566948 8.879098e-01 0.052 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.879098e-01 0.052 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.883097e-01 0.051 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.912696e-01 0.050 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.933937e-01 0.049 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.933937e-01 0.049 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.942835e-01 0.049 0 0
Ribavirin ADME R-HSA-9755088 8.942835e-01 0.049 0 0
Assembly Of The HIV Virion R-HSA-175474 8.942835e-01 0.049 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.945192e-01 0.048 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.950631e-01 0.048 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.950631e-01 0.048 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.950631e-01 0.048 0 0
Signaling by ALK R-HSA-201556 8.950631e-01 0.048 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.950631e-01 0.048 0 0
Ribosome-associated quality control R-HSA-9948299 8.961624e-01 0.048 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.004168e-01 0.046 0 0
Ion homeostasis R-HSA-5578775 9.004168e-01 0.046 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.017895e-01 0.045 0 0
Glycogen metabolism R-HSA-8982491 9.017895e-01 0.045 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.027323e-01 0.044 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.027323e-01 0.044 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.027323e-01 0.044 0 0
LDL clearance R-HSA-8964038 9.027323e-01 0.044 0 0
IRS-mediated signalling R-HSA-112399 9.060153e-01 0.043 0 0
Synthesis of PA R-HSA-1483166 9.060153e-01 0.043 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.105064e-01 0.041 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.105064e-01 0.041 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.105064e-01 0.041 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.105064e-01 0.041 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.113273e-01 0.040 0 0
Neurotransmitter release cycle R-HSA-112310 9.135681e-01 0.039 0 0
Downstream TCR signaling R-HSA-202424 9.135681e-01 0.039 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.140511e-01 0.039 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.140511e-01 0.039 1 1
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.140511e-01 0.039 1 1
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.152081e-01 0.038 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.163650e-01 0.038 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.167438e-01 0.038 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.176596e-01 0.037 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.176596e-01 0.037 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.176596e-01 0.037 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.176596e-01 0.037 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.176596e-01 0.037 0 0
Complex III assembly R-HSA-9865881 9.176596e-01 0.037 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.176596e-01 0.037 0 0
Interleukin-6 family signaling R-HSA-6783589 9.176596e-01 0.037 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.179848e-01 0.037 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.190175e-01 0.037 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.190175e-01 0.037 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.196286e-01 0.036 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.196286e-01 0.036 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.211406e-01 0.036 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.211406e-01 0.036 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.211406e-01 0.036 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.211406e-01 0.036 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.211406e-01 0.036 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.242414e-01 0.034 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.242414e-01 0.034 0 0
G protein gated Potassium channels R-HSA-1296059 9.242414e-01 0.034 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.242414e-01 0.034 0 0
Tight junction interactions R-HSA-420029 9.242414e-01 0.034 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.242414e-01 0.034 0 0
Hyaluronan degradation R-HSA-2160916 9.242414e-01 0.034 0 0
Formation of the nephric duct R-HSA-9830364 9.242414e-01 0.034 0 0
Laminin interactions R-HSA-3000157 9.242414e-01 0.034 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.242414e-01 0.034 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.242414e-01 0.034 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.256655e-01 0.034 0 0
Aquaporin-mediated transport R-HSA-445717 9.256655e-01 0.034 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.256655e-01 0.034 0 0
RNA Polymerase I Transcription R-HSA-73864 9.263086e-01 0.033 0 0
ABC transporter disorders R-HSA-5619084 9.263086e-01 0.033 0 0
Ion channel transport R-HSA-983712 9.266071e-01 0.033 0 0
Surfactant metabolism R-HSA-5683826 9.297767e-01 0.032 0 0
Proteasome assembly R-HSA-9907900 9.297767e-01 0.032 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.297767e-01 0.032 0 0
Netrin-1 signaling R-HSA-373752 9.297767e-01 0.032 0 0
MET activates PTK2 signaling R-HSA-8874081 9.302974e-01 0.031 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.302974e-01 0.031 0 0
Urea cycle R-HSA-70635 9.302974e-01 0.031 0 0
Abacavir ADME R-HSA-2161522 9.302974e-01 0.031 0 0
Sphingolipid catabolism R-HSA-9845614 9.302974e-01 0.031 0 0
Stimuli-sensing channels R-HSA-2672351 9.327970e-01 0.030 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.338635e-01 0.030 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 9.343843e-01 0.029 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.358697e-01 0.029 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.358697e-01 0.029 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.358697e-01 0.029 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.358697e-01 0.029 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.358697e-01 0.029 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.358697e-01 0.029 0 0
Triglyceride biosynthesis R-HSA-75109 9.358697e-01 0.029 0 0
Synthesis of PE R-HSA-1483213 9.358697e-01 0.029 0 0
Insulin processing R-HSA-264876 9.358697e-01 0.029 0 0
Insulin receptor signalling cascade R-HSA-74751 9.378480e-01 0.028 0 0
Ion transport by P-type ATPases R-HSA-936837 9.378480e-01 0.028 0 0
Integration of energy metabolism R-HSA-163685 9.385069e-01 0.028 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.387045e-01 0.027 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.387045e-01 0.027 0 0
Formation of the cornified envelope R-HSA-6809371 9.396849e-01 0.027 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.407096e-01 0.027 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.409968e-01 0.026 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.409968e-01 0.026 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.409968e-01 0.026 0 0
Prednisone ADME R-HSA-9757110 9.409968e-01 0.026 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.409968e-01 0.026 0 0
Pyroptosis R-HSA-5620971 9.409968e-01 0.026 0 0
Parasitic Infection Pathways R-HSA-9824443 9.418685e-01 0.026 0 0
Leishmania infection R-HSA-9658195 9.418685e-01 0.026 0 0
Synthesis of PC R-HSA-1483191 9.427536e-01 0.026 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.438848e-01 0.025 0 0
Cellular response to chemical stress R-HSA-9711123 9.441697e-01 0.025 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.456566e-01 0.024 0 0
DNA methylation R-HSA-5334118 9.457143e-01 0.024 0 0
Platelet calcium homeostasis R-HSA-418360 9.457143e-01 0.024 0 0
Glucagon-type ligand receptors R-HSA-420092 9.457143e-01 0.024 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.457143e-01 0.024 0 0
GPER1 signaling R-HSA-9634597 9.465475e-01 0.024 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.481608e-01 0.023 0 0
Leishmania phagocytosis R-HSA-9664417 9.483069e-01 0.023 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.483069e-01 0.023 0 0
Parasite infection R-HSA-9664407 9.483069e-01 0.023 0 0
Neurotransmitter clearance R-HSA-112311 9.500549e-01 0.022 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.500549e-01 0.022 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.501009e-01 0.022 0 0
Regulated Necrosis R-HSA-5218859 9.512283e-01 0.022 0 0
Azathioprine ADME R-HSA-9748787 9.534281e-01 0.021 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.540486e-01 0.020 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.540486e-01 0.020 0 0
Translation R-HSA-72766 9.551318e-01 0.020 0 0
Hemostasis R-HSA-109582 9.576439e-01 0.019 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.577233e-01 0.019 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.594438e-01 0.018 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.594438e-01 0.018 0 0
Peptide chain elongation R-HSA-156902 9.598831e-01 0.018 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.611042e-01 0.017 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.621835e-01 0.017 0 0
Neddylation R-HSA-8951664 9.627239e-01 0.016 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.642150e-01 0.016 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.642150e-01 0.016 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.642150e-01 0.016 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.661909e-01 0.015 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.663464e-01 0.015 0 0
eNOS activation R-HSA-203615 9.670771e-01 0.015 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.670771e-01 0.015 0 0
Hyaluronan metabolism R-HSA-2142845 9.670771e-01 0.015 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.670771e-01 0.015 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.670771e-01 0.015 0 0
Paracetamol ADME R-HSA-9753281 9.671176e-01 0.015 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.680795e-01 0.014 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.697105e-01 0.013 0 0
PERK regulates gene expression R-HSA-381042 9.697105e-01 0.013 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.697105e-01 0.013 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.698693e-01 0.013 1 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.708704e-01 0.013 0 0
Translation of Structural Proteins R-HSA-9694635 9.721297e-01 0.012 1 0
Triglyceride catabolism R-HSA-163560 9.721334e-01 0.012 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.721334e-01 0.012 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.738385e-01 0.012 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.743626e-01 0.011 0 0
Voltage gated Potassium channels R-HSA-1296072 9.743626e-01 0.011 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.743626e-01 0.011 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.743626e-01 0.011 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.743626e-01 0.011 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.743626e-01 0.011 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.746917e-01 0.011 0 0
PPARA activates gene expression R-HSA-1989781 9.750368e-01 0.011 0 0
Peroxisomal protein import R-HSA-9033241 9.751920e-01 0.011 0 0
Regulation of beta-cell development R-HSA-186712 9.751920e-01 0.011 0 0
Triglyceride metabolism R-HSA-8979227 9.751920e-01 0.011 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.751920e-01 0.011 0 0
Eukaryotic Translation Termination R-HSA-72764 9.761312e-01 0.010 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.764137e-01 0.010 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.764137e-01 0.010 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.764888e-01 0.010 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.764888e-01 0.010 0 0
tRNA Aminoacylation R-HSA-379724 9.768892e-01 0.010 0 0
Metabolism of polyamines R-HSA-351202 9.768892e-01 0.010 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.772881e-01 0.010 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.783007e-01 0.010 0 0
Pentose phosphate pathway R-HSA-71336 9.783007e-01 0.010 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.783424e-01 0.010 0 0
Interferon gamma signaling R-HSA-877300 9.793515e-01 0.009 0 0
Regulation of insulin secretion R-HSA-422356 9.800013e-01 0.009 0 0
HIV Transcription Elongation R-HSA-167169 9.800369e-01 0.009 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.800369e-01 0.009 0 0
Tryptophan catabolism R-HSA-71240 9.800369e-01 0.009 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.807644e-01 0.008 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.811540e-01 0.008 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.816342e-01 0.008 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.816342e-01 0.008 0 0
Maturation of spike protein R-HSA-9694548 9.816342e-01 0.008 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.821798e-01 0.008 0 0
Intra-Golgi traffic R-HSA-6811438 9.831039e-01 0.007 0 0
Translation of Structural Proteins R-HSA-9683701 9.831039e-01 0.007 0 0
Selenocysteine synthesis R-HSA-2408557 9.832736e-01 0.007 0 0
Activation of GABAB receptors R-HSA-991365 9.844560e-01 0.007 0 0
GABA B receptor activation R-HSA-977444 9.844560e-01 0.007 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.844560e-01 0.007 0 0
Depyrimidination R-HSA-73928 9.844560e-01 0.007 0 0
Infectious disease R-HSA-5663205 9.845833e-01 0.007 1 0
Viral mRNA Translation R-HSA-192823 9.851660e-01 0.006 0 0
Defensins R-HSA-1461973 9.857000e-01 0.006 0 0
G1 Phase R-HSA-69236 9.868444e-01 0.006 0 0
Cyclin D associated events in G1 R-HSA-69231 9.868444e-01 0.006 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.868444e-01 0.006 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.868444e-01 0.006 0 0
RSV-host interactions R-HSA-9833110 9.868539e-01 0.006 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.872525e-01 0.006 0 0
Platelet homeostasis R-HSA-418346 9.883580e-01 0.005 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.888661e-01 0.005 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.888661e-01 0.005 0 0
Metabolism of porphyrins R-HSA-189445 9.895050e-01 0.005 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.897574e-01 0.004 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.904723e-01 0.004 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.904723e-01 0.004 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.904723e-01 0.004 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.905774e-01 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.907325e-01 0.004 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.908884e-01 0.004 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.913317e-01 0.004 0 0
Complex IV assembly R-HSA-9864848 9.926642e-01 0.003 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.926642e-01 0.003 0 0
The phototransduction cascade R-HSA-2514856 9.926642e-01 0.003 0 0
Cardiac conduction R-HSA-5576891 9.936716e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.937012e-01 0.003 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.941029e-01 0.003 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.942891e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.946214e-01 0.002 0 0
G alpha (z) signalling events R-HSA-418597 9.947465e-01 0.002 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.948610e-01 0.002 0 0
Amyloid fiber formation R-HSA-977225 9.949476e-01 0.002 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.951673e-01 0.002 0 0
Metabolism of proteins R-HSA-392499 9.955515e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.955544e-01 0.002 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.959511e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.965394e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.965394e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.965394e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.967581e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.968167e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.969902e-01 0.001 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.970717e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.972491e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.973064e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.975928e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.977268e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.979034e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.980714e-01 0.001 0 0
Kidney development R-HSA-9830369 9.980714e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.980714e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.982150e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.982260e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.982521e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.983440e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.983440e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.984949e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.984990e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.986193e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.986193e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.986465e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.986465e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.986781e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.987156e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.987300e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.988318e-01 0.001 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.989255e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.990294e-01 0.000 0 0
Disease R-HSA-1643685 9.991409e-01 0.000 1 0
PI Metabolism R-HSA-1483255 9.991595e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.991882e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.992618e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.993062e-01 0.000 0 0
Keratinization R-HSA-6805567 9.994358e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.995573e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.996070e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.996359e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.997516e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.997566e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997853e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.998613e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998672e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998877e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999261e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999293e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999437e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999524e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999589e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999637e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999640e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999797e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999892e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999892e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999897e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999909e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999918e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999931e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999954e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999966e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999969e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999976e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999986e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999988e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999990e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999992e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999993e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999998e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways