CK1G1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A6NMY6	S127	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
O00566	S171	Sugiyama	MPHOSPH10 MPP10	RAENSSKsDLRKsPVFsDEDsDLDFDISKLEQQSKVQNKGQ
O00571	S70	Sugiyama	DDX3X DBX DDX3	KGFyDKDSSGWsssKDKDAyssFGsRsDsRGKssFFsDRGs
O14980	S450	Sugiyama	XPO1 CRM1	VLVVENDQGEVVREFMKDTDsINLyKNMRETLVyLTHLDyV
O15523	S70	Sugiyama	DDX3Y DBY	KGFHDKDSSGWSCSKDKDAyssFGsRDSRGKPGYFSERGSG
O43390	S23	Sugiyama	HNRNPR HNRPR	NQVNGNAVQLKEEEEPMDtssVTHTEHYKtLIEAGLPQKVA
O43615	S193	Sugiyama	TIMM44 MIMT44 TIM44	TAAFRALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEF
O43707	T445	Sugiyama	ACTN4	HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43815	S229	Sugiyama	STRN	TEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDEDE
O43823	S124	Sugiyama	AKAP8 AKAP95	SKEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHN
O43852	S261	Sugiyama	CALU	RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852	S300	Sugiyama	CALU	NKDGKLTKEEIVDKyDLFVGsQAtDFGEALVRHDEF_____
O43852	S44	Sugiyama	CALU	KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852	T303	Sugiyama	CALU	GKLTKEEIVDKyDLFVGsQAtDFGEALVRHDEF________
O60231	S112	Sugiyama	DHX16 DBP2 DDX16 KIAA0577 PRP2	EKNRSYRLLEDsEEssEEtVsRAGsSLQKKRKKRKHLRKKR
O60664	S225	Sugiyama	PLIN3 M6PRBP1 TIP47	PLTDAELARIAtsLDGFDVAsVQQQRQEQSyFVRLGsLSER
O60701	S392	Sugiyama	UGDH	PREQIVVDLsHPGVSEDDQVsRLVTISKDPYEACDGAHAVV
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841	S222	Sugiyama	EIF5B IF2 KIAA0741	KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O60841	S66	Sugiyama	EIF5B IF2 KIAA0741	KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O75581	T1479	SIGNOR\|PSP	LRP6	PYDRAHVTGASSSSSssTKGtYFPAILNPPPsPAtERsHYT
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95302	S275	Sugiyama	FKBP9 FKBP60 FKBP63	NPKDSISIENKVVPENCERIsQsGDFLRYHYNGTLLDGTLF
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05556	S509	Sugiyama	ITGB1 FNRB MDF2 MSK12	CRCNEGRVGRHCECstDEVNsEDMDAYCRKENSSEICSNNG
P05787	S258	Sugiyama	KRT8 CYK8	QISDTSVVLsMDNSRsLDMDsIIAEVKAQyEDIANRsRAEA
P05787	S280	Sugiyama	KRT8 CYK8	IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL
P05787	S291	Sugiyama	KRT8 CYK8	ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07355	S127	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	AQyDAsELKAsMKGLGtDEDsLIEIICsRtNQELQEINRVy
P07355	S184	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07948	S13	SIGNOR\|PSP	LYN JTK8	________MGCIKSKGKDsLsDDGVDLKTQPVRNTERTIyV
P08195	S292	Sugiyama	SLC3A2 MDU1	VAQtDLLQIDPNFGsKEDFDsLLQsAKKKSIRVILDLTPNY
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S532	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	yMtEPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKK
P08238	S535	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	EPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
P08238	T297	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238	Y301	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08670	S214	Sugiyama	VIM	LQREEAENtLQsFRQDVDNAsLARLDLERKVEsLQEEIAFL
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09960	S240	Sugiyama	LTA4H LTA4	LVWSEKEQVEKSAyEFsETEsMLKIAEDLGGPYVWGQYDLL
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG47	S57	Sugiyama	UBB	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG47	T55	Sugiyama	UBB	GIPPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRG
P0CG48	S57	Sugiyama	UBC	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48	T55	Sugiyama	UBC	GIPPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRG
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11586	T128	Sugiyama	MTHFD1 MTHFC MTHFD	SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P13010	S318	Sugiyama	XRCC5 G22P2	NDDDETEVLKEDIIQGFRyGsDIVPFSKVDEEQMKYKSEGK
P13489	S290	Sugiyama	RNH1 PRI RNH	AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639	S584	Sugiyama	EEF2 EF2	DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639	S587	Sugiyama	EEF2 EF2	CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625	S523	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	RtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMAG
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P18621	S111	Sugiyama	RPL17	LLHMLKNAESNAELKGLDVDsLVIEHIQVNKAPKMRRRTYR
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	S619	Sugiyama	NCL	RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P19338	Y462	Sugiyama	NCL	AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P20042	S158	Sugiyama	EIF2S2 EIF2B	EILEKDEALEDEDNKKDDGIsFsNQtGPAWAGSERDytyEE
P20810	S311	Sugiyama	CAST	LEALsAsLGTRQAEPELDLRsIKEVDEAKAKEEKLEKCGED
P23396	S35	Sugiyama	RPS3 OK/SW-cl.26	GIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATRT
P25054	S1504	PSP	APC DP2.5	DADTLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELRI
P25054	S1505	PSP	APC DP2.5	ADTLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELRIM
P25054	S1507	PSP	APC DP2.5	TLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELRIMPP
P25054	S1510	PSP	APC DP2.5	HFATESTPDGFsCsssLsALsLDEPFIQKDVELRIMPPVQE
P25705	S53	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR
P25788	S243	Sugiyama	PSMA3 HC8 PSC8	GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P26639	S522	Sugiyama	TARS1 TARS	PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P26641	S304	Sugiyama	EEF1G EF1G PRO1608	PKstFVLDEFKRKysNEDtLsVALPyFWEHFDKDGWSLWyS
P26641	T302	Sugiyama	EEF1G EF1G PRO1608	HLPKstFVLDEFKRKysNEDtLsVALPyFWEHFDKDGWSLW
P27797	S195	Sugiyama	CALR CRTC	IVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIKDPDAsK
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P28340	S60	Sugiyama	POLD1 POLD	LMEEMEAEHRLQEQEEEELQsVLEGVADGQVPPsAIDPRWL
P29401	S295	Sugiyama	TKT	ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P30041	S186	Sugiyama	PRDX6 AOP2 KIAA0106	SLQLTAEKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGV
P30043	S198	Sugiyama	BLVRB FLR SCAN	KHDLGHFMLRCLttDEyDGHstyPsHQyQ____________
P30043	T199	Sugiyama	BLVRB FLR SCAN	HDLGHFMLRCLttDEyDGHstyPsHQyQ_____________
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050	S157	Sugiyama	RPL12	QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P31327	S1090	Sugiyama	CPS1	KNGVKIMGTsPLQIDRAEDRsIFsAVLDELKVAQAPWKAVN
P31327	S1093	Sugiyama	CPS1	VKIMGTsPLQIDRAEDRsIFsAVLDELKVAQAPWKAVNTLN
P31327	S863	Sugiyama	CPS1	LSEPSsTRIyAIAKAIDDNMsLDEIEKLTYIDKWFLYKMRD
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35580	S1013	Sugiyama	MYH10	QNSKFIKEKKLMEDRIAECssQLAEEEEKAKNLAKIRNKQE
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40925	S326	Sugiyama	MDH1 MDHA	NDFSREKMDLTAKELtEEKEsAFEFLssA____________
P40925	T321	Sugiyama	MDH1 MDHA	EGLPINDFSREKMDLTAKELtEEKEsAFEFLssA_______
P42696	T91	Sugiyama	RBM34 KIAA0117	YVPVPKQTIKKTKRNEEEEstsQIERPLsQEPAKKVKAKKK
P43487	S188	Sugiyama	RANBP1	KAGSGKNDHAEKVAEKLEALsVKEETKEDAEEKQ_______
P45974	S783	Sugiyama	USP5 ISOT	IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P47756	S204	Sugiyama	CAPZB	sGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMENKI
P48643	S270	Sugiyama	CCT5 CCTE KIAA0098	ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49368	T484	Sugiyama	CCT3 CCTG TRIC5	tSLRAKHtQENCEtWGVNGEtGtLVDMKELGIWEPLAVKLQ
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P54577	S386	Sugiyama	YARS1 YARS	sRLDIRVGKIITVEKHPDADsLyVEKIDVGEAEPRTVVSGL
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55884	S185	Sugiyama	EIF3B EIF3S9	EEELLGDVLKDRPQEADGIDsVIVVDNVPQVGPDRLEKLKN
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	S60	Sugiyama	ACTB	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61916	S29	Sugiyama	NPC2 HE1	LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62495	S295	Sugiyama	ETF1 ERF1 RF1 SUP45L1	LSNVKFIQEKKLIGRyFDEIsQDtGKyCFGVEDTLKALEMG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	S62	Sugiyama	ACTA2 ACTSA ACTVS GIG46	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62857	T57	Sugiyama	RPS28	DtsRsIIRNVKGPVREGDVLtLLEsEREARRLR________
P62979	S57	Sugiyama	RPS27A UBA80 UBCEP1	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62979	T55	Sugiyama	RPS27A UBA80 UBCEP1	GIPPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRG
P62987	S57	Sugiyama	UBA52 UBCEP2	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P62987	T55	Sugiyama	UBA52 UBCEP2	GIPPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRG
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63151	S409	Sugiyama	PPP2R2A	RTVLKPRKVCASGKRKKDEIsVDsLDFNKKILHTAWHPKEN
P63151	S412	Sugiyama	PPP2R2A	LKPRKVCASGKRKKDEIsVDsLDFNKKILHTAWHPKENIIA
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	S60	Sugiyama	ACTG1 ACTG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	S61	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	S62	Sugiyama	ACTC1 ACTC	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S62	Sugiyama	ACTA1 ACTA	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	T80	Sugiyama	TUBA1B	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q00610	S1494	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	EEDyQALRTsIDAyDNFDNIsLAQRLEKHELIEFRRIAAYL
Q00839	S59	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	QAALDDEEAGGRPAMEPGNGsLDLGGDsAGRSGAGLEQEAA
Q01105	S133	Sugiyama	SET	DEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLS
Q01105	T169	Sugiyama	SET	NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02952	S1256	Sugiyama	AKAP12 AKAP250	QSKMEDtLEHTDKEVsVEtVsILsKTEGtQEADQyADEKTK
Q02952	S1259	Sugiyama	AKAP12 AKAP250	MEDtLEHTDKEVsVEtVsILsKTEGtQEADQyADEKTKDVP
Q04206	S536	PSP	RELA NFKB3	APLGAPGLPNGLLsGDEDFSsIADMDFsALLSQISS_____
Q07021	S201	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	ALVLDCHyPEDEVGQEDEAEsDIFsIREVsFQstGESEWKD
Q07021	S205	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	DCHyPEDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYT
Q07021	S87	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	CGCGCGSLHTDGDKAFVDFLsDEIKEERKIQKHKTLPKMsG
Q07157	S1065	Sugiyama	TJP1 ZO1	YVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRVP
Q12778	S322	SIGNOR\|iPTMNet	FOXO1 FKHR FOXO1A	HsNDDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGD
Q12778	S325	SIGNOR	FOXO1 FKHR FOXO1A	DDFDNWSTFRPRtssNAstIsGRLsPIMtEQDDLGEGDVHS
Q12906	S190	Sugiyama	ILF3 DRBF MPHOSPH4 NF90	HLTSPVVREEMEKVLAGEtLsVNDPPDVLDRQKCLAALASL
Q12965	S1009	Sugiyama	MYO1E MYO1C	yTsMARPPLPRQQstssDRVsQtPEsLDFLKVPDQGAAGVR
Q13435	S317	Sugiyama	SF3B2 SAP145	ETDARssLGQsAsEtEEDtVsVsKKEKNRKRRNRKKKKKPQ
Q13541	S112	Sugiyama	EIF4EBP1	EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q14151	S195	Sugiyama	SAFB2 KIAA0138	AQPPEHAVDGEGFKNtLEtssLNFKVtPDIEEsLLEPENEK
Q14151	S246	Sugiyama	SAFB2 KIAA0138	sEPVKEEssELEQPFAQDtssVGPDRKLAEEEDLFDsAHPE
Q14192	S257	Sugiyama	FHL2 DRAL SLIM3	IsFEERQWHNDCFNCKKCsLsLVGRGFLTERDDILCPDCGK
Q14257	S146	Sugiyama	RCN2 ERC55	MyDRVIDFDENtALDDAEEEsFRKLHLKDKKRFEKANQDSG
Q14257	T137	Sugiyama	RCN2 ERC55	VTWDEyNIQMyDRVIDFDENtALDDAEEEsFRKLHLKDKKR
Q14498	S334	Sugiyama	RBM39 HCC1 RNPC2	FELAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtT
Q14498	S337	Sugiyama	RBM39 HCC1 RNPC2	AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL
Q14498	T330	Sugiyama	RBM39 HCC1 RNPC2	QLNGFELAGRPMKVGHVTERtDAssAssFLDsDELERtGID
Q14978	S637	Sugiyama	NOLC1 KIAA0035 NS5ATP13	GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER
Q14C86	S740	Sugiyama	GAPVD1 GAPEX5 KIAA1521 RAP6	LPSDSEAPDLKQEERLQELEsCsGLGstSDDTDVREVSSRP
Q15056	S94	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	RDKDTDKFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVD
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15181	S127	Sugiyama	PPA1 IOPPP PP	NDKHTGCCGDNDPIDVCEIGsKVCARGEIIGVKVLGILAMI
Q15293	T71	Sugiyama	RCN1 RCN	EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI
Q15424	S247	Sugiyama	SAFB HAP HET SAFB1	sEPVKEEssELEQPFAQDtssVGPDRKLAEEEDLFDsAHPE
Q15459	S690	Sugiyama	SF3A1 SAP114	VHPPPPMEDEPTSKKLKTEDsLMPEEEFLRRNKGPVSIKVQ
Q58FF7	S405	Sugiyama	HSP90AB3P HSP90BC	YMTEPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKK
Q58FF7	S408	Sugiyama	HSP90AB3P HSP90BC	EPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
Q58FF8	S305	Sugiyama	HSP90AB2P HSP90BB	RVVYMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKR
Q58FF8	S308	Sugiyama	HSP90AB2P HSP90BB	YMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKRMEE
Q5UIP0	S1693	Sugiyama	RIF1	NLRTRNAIKRLHKRDsFDNCsLGESSKIGIsDIssLsEKtF
Q66LE6	S415	Sugiyama	PPP2R2D KIAA1541	RASLKPRKVCTGGKRRKDEIsVDsLDFNKKILHTAWHPVDN
Q66LE6	S418	Sugiyama	PPP2R2D KIAA1541	LKPRKVCTGGKRRKDEIsVDsLDFNKKILHTAWHPVDNVIA
Q6NZY4	S605	Sugiyama	ZCCHC8	EIFTKKsEAGHAssPDsEVTsLCQKEKAELAPVNTEGALLD
Q6P996	S718	Sugiyama	PDXDC1 KIAA0251	KQRLPGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssG
Q6P996	S721	Sugiyama	PDXDC1 KIAA0251	LPGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQ
Q6P996	S722	Sugiyama	PDXDC1 KIAA0251	PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6P996	S779	Sugiyama	PDXDC1 KIAA0251	QHtDQtEAFQKGVPHPEDDHsQVEGPEsLR___________
Q6PCE3	S311	Sugiyama	PGM2L1 BM32A	QKDPDPDFSTVKCPNPEEGEsVLELsLRLAEKENARVVLAT
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ULP2	S582	Sugiyama	AFTPH AFTH	SSAGPSQVVDWNAFEDEQKDsCsWAAFGDQQATESHHRKEA
Q6ULP2	S584	Sugiyama	AFTPH AFTH	AGPSQVVDWNAFEDEQKDsCsWAAFGDQQATESHHRKEAWQ
Q6UXH1	S295	Sugiyama	CRELD2 UNQ185/PRO211	KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	T80	Sugiyama	TUBA1A TUBA3	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q8IWS0	S183	Sugiyama	PHF6 CENP-31 KIAA1823	RKGRPRKTNFKGLSEDtRstssHGtDEMEsssyRDRsPHRs
Q8IWS0	S184	Sugiyama	PHF6 CENP-31 KIAA1823	KGRPRKTNFKGLSEDtRstssHGtDEMEsssyRDRsPHRss
Q8N5F7	S266	Sugiyama	NKAP	SKKYKKKRSKKSRKESSDSSsKEsQEEFLENPWKDRTKAEE
Q8N5F7	S269	Sugiyama	NKAP	YKKKRSKKSRKESSDSSsKEsQEEFLENPWKDRTKAEEPSD
Q8N6T3	S348	Sugiyama	ARFGAP1 ARF1GAP	FWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWG
Q8N6T3	T350	Sugiyama	ARFGAP1 ARF1GAP	ETFGSAEPTKtRKsPssDsWtCADtstERRssDsWEVWGSA
Q8NBJ7	S283	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	GsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPPGEL__
Q8ND56	S374	Sugiyama	LSM14A C19orf13 FAM61A RAP55 RAP55A	EDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEERRLNAE
Q8WU90	S351	Sugiyama	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	DIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLsEAs
Q8WU90	T348	Sugiyama	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	sVNDIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLs
Q96CT7	S122	Sugiyama	CCDC124	DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q99622	S97	Sugiyama	C12orf57 C10	GVLKFARLVKSYEAQDPEIAsLSGKLKALFLPPMTLPPHGP
Q99733	S121	Sugiyama	NAP1L4 NAP2	PLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKV
Q99848	S269	Sugiyama	EBNA1BP2 EBP2	GFGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGS
Q99848	S270	Sugiyama	EBNA1BP2 EBP2	FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	T80	Sugiyama	TUBA1C TUBA6	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BTC0	S352	Sugiyama	DIDO1 C20orf158 DATF1 KIAA0333	TADQQEAKWRPGDADGTDCTsIGtIEQKSSEDQGIKGRIEK
Q9BTC0	T355	Sugiyama	DIDO1 C20orf158 DATF1 KIAA0333	QQEAKWRPGDADGTDCTsIGtIEQKSSEDQGIKGRIEKAAN
Q9BVS4	S412	Sugiyama	RIOK2 RIO2	EMTEFNQALEEIKGQVVENNsVTEFsEEKNRTENYNRQDGQ
Q9BWU0	S709	Sugiyama	SLC4A1AP HLC3	SRGELKKKKTPGPGKLPPTLsSKYPEDDPDYCVWVPPEGQS
Q9BY32	S53	Sugiyama	ITPA C20orf37 My049 OK/SW-cl.9	CTLVAQKIDLPEyQGEPDEIsIQKCQEAVRQVQGPVLVEDT
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9GZZ9	T386	Sugiyama	UBA5 UBE1DC1	EGITVAytIPKKQEDsVTELtVEDSGESLEDLMAKMKNM__
Q9H3P7	S393	Sugiyama	ACBD3 GCP60 GOCAP1 GOLPH1	SMWTRPQIKDFKEKIQQDADsVItVGRGEVVTVRVPTHEEG
Q9H3P7	T396	Sugiyama	ACBD3 GCP60 GOCAP1 GOLPH1	TRPQIKDFKEKIQQDADsVItVGRGEVVTVRVPTHEEGSYL
Q9NQE9	S46	Sugiyama	HINT3	VssVGTCEAAGKsPEPKDyDstCVFCRIAGRQDPGTELLHC
Q9NR28	S230	Sugiyama	DIABLO SMAC	EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NR30	S466	Sugiyama	DDX21	ETKKEAQELSQNsAIKQDAQsLHGDIPQKQREITLKGFRNG
Q9NX58	S32	Sugiyama	LYAR PNAS-5	sVKKIQVEKHVSVCRNCECLsCIDCGKDFWGDDYKNHVKCI
Q9NZL9	S110	Sugiyama	MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995	IVHCAAERRPDVVENQPDAAsQLNVDASGNLAKEAAAVGAF
Q9P2E9	S1122	Sugiyama	RRBP1 KIAA1398	APAEPSSDLASKLREAEEtQstLQAECDQYRSILAETEGML
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y696	S31	Sugiyama	CLIC4	KEEDKEPLIELFVKAGsDGEsIGNCPFSQRLFMILWLKGVV

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Signal Transduction	R-HSA-162582	4.997825e-09	8.301
M Phase	R-HSA-68886	4.863833e-07	6.313
Nuclear Envelope Breakdown	R-HSA-2980766	4.137109e-06	5.383
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.166088e-05	4.933
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.630882e-05	4.788
Cell-Cell communication	R-HSA-1500931	2.061621e-05	4.686
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.314097e-05	4.480
Cellular response to heat stress	R-HSA-3371556	3.280320e-05	4.484
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.756137e-05	4.425
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.210088e-05	4.376
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	4.604230e-05	4.337
Cell junction organization	R-HSA-446728	4.750274e-05	4.323
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.151856e-05	4.288
Mitotic Anaphase	R-HSA-68882	5.321179e-05	4.274
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.830938e-05	4.234
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	6.629386e-05	4.179
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.718852e-05	4.112
Oncogenic MAPK signaling	R-HSA-6802957	7.347910e-05	4.134
Transport of the SLBP independent Mature mRNA	R-HSA-159227	8.726949e-05	4.059
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	8.732126e-05	4.059
Mitotic Prometaphase	R-HSA-68877	1.022513e-04	3.990
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.116857e-04	3.952
Separation of Sister Chromatids	R-HSA-2467813	1.088700e-04	3.963
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.606887e-04	3.794
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.786137e-04	3.748
Apoptotic execution phase	R-HSA-75153	1.887980e-04	3.724
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.056890e-04	3.687
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.056890e-04	3.687
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.326834e-04	3.633
Specification of primordial germ cells	R-HSA-9827857	2.410985e-04	3.618
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.773987e-04	3.557
Cell Cycle	R-HSA-1640170	2.948269e-04	3.530
IPs transport between nucleus and cytosol	R-HSA-1855170	3.284814e-04	3.483
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.422073e-04	3.466
Nervous system development	R-HSA-9675108	3.141353e-04	3.503
Cell Cycle, Mitotic	R-HSA-69278	3.470411e-04	3.460
Mitotic Prophase	R-HSA-68875	3.823252e-04	3.418
Death Receptor Signaling	R-HSA-73887	3.871808e-04	3.412
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.261411e-04	3.370
Chromatin organization	R-HSA-4839726	4.180901e-04	3.379
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	4.101722e-04	3.387
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.194773e-04	3.377
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.641793e-04	3.333
Chromatin modifying enzymes	R-HSA-3247509	4.660649e-04	3.332
Interactions of Rev with host cellular proteins	R-HSA-177243	5.110723e-04	3.292
Interactions of Vpr with host cellular proteins	R-HSA-176033	5.110723e-04	3.292
Nuclear import of Rev protein	R-HSA-180746	5.083812e-04	3.294
HIV Life Cycle	R-HSA-162587	5.124344e-04	3.290
Late Phase of HIV Life Cycle	R-HSA-162599	5.369958e-04	3.270
Cellular Senescence	R-HSA-2559583	5.294768e-04	3.276
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	6.028005e-04	3.220
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	7.456547e-04	3.127
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	9.874925e-04	3.005
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.113687e-03	2.953
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.110709e-03	2.954
Axon guidance	R-HSA-422475	1.110016e-03	2.955
Signaling by Hippo	R-HSA-2028269	1.113687e-03	2.953
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.392841e-03	2.856
Transport of connexons to the plasma membrane	R-HSA-190872	1.469057e-03	2.833
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.469057e-03	2.833
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.490822e-03	2.827
Cell-cell junction organization	R-HSA-421270	1.545267e-03	2.811
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.644670e-03	2.784
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.612756e-03	2.792
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.717817e-03	2.765
Signaling downstream of RAS mutants	R-HSA-9649948	1.751798e-03	2.757
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.751798e-03	2.757
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.751798e-03	2.757
Signaling by RAS mutants	R-HSA-6802949	1.751798e-03	2.757
HIV Infection	R-HSA-162906	1.694211e-03	2.771
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.751798e-03	2.757
Post NMDA receptor activation events	R-HSA-438064	1.756547e-03	2.755
Kinesins	R-HSA-983189	1.883894e-03	2.725
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.906295e-03	2.720
Recycling pathway of L1	R-HSA-437239	2.049423e-03	2.688
Cell-extracellular matrix interactions	R-HSA-446353	2.078733e-03	2.682
Interleukin-37 signaling	R-HSA-9008059	2.101556e-03	2.677
ISG15 antiviral mechanism	R-HSA-1169408	2.109341e-03	2.676
Signaling by RAF1 mutants	R-HSA-9656223	2.251150e-03	2.648
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.330628e-03	2.633
Cohesin Loading onto Chromatin	R-HSA-2470946	2.479281e-03	2.606
Formation of definitive endoderm	R-HSA-9823730	2.446486e-03	2.611
L1CAM interactions	R-HSA-373760	2.559380e-03	2.592
Gap junction trafficking and regulation	R-HSA-157858	2.769947e-03	2.558
NRAGE signals death through JNK	R-HSA-193648	2.820148e-03	2.550
Transcriptional Regulation by TP53	R-HSA-3700989	2.836354e-03	2.547
Nuclear Receptor transcription pathway	R-HSA-383280	3.008934e-03	2.522
G alpha (12/13) signalling events	R-HSA-416482	3.008934e-03	2.522
Diseases of mitotic cell cycle	R-HSA-9675126	3.075385e-03	2.512
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.386874e-03	2.470
Formation of annular gap junctions	R-HSA-196025	3.708153e-03	2.431
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.511512e-03	2.455
HSF1-dependent transactivation	R-HSA-3371571	3.685217e-03	2.434
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.681616e-03	2.434
Transcriptional regulation by small RNAs	R-HSA-5578749	3.511512e-03	2.455
Gap junction trafficking	R-HSA-190828	3.601938e-03	2.443
Regulation of MECP2 expression and activity	R-HSA-9022692	3.681616e-03	2.434
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.681616e-03	2.434
Autophagy	R-HSA-9612973	3.547592e-03	2.450
Membrane Trafficking	R-HSA-199991	3.653348e-03	2.437
PKR-mediated signaling	R-HSA-9833482	3.769822e-03	2.424
Mitotic Spindle Checkpoint	R-HSA-69618	3.853528e-03	2.414
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.943072e-03	2.404
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.943072e-03	2.404
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.944927e-03	2.404
Transcriptional Regulation by E2F6	R-HSA-8953750	4.005046e-03	2.397
snRNP Assembly	R-HSA-191859	4.190556e-03	2.378
Metabolism of non-coding RNA	R-HSA-194441	4.190556e-03	2.378
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.315927e-03	2.365
Cellular responses to stress	R-HSA-2262752	4.204510e-03	2.376
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.542951e-03	2.343
Regulation of TP53 Activity	R-HSA-5633007	4.782200e-03	2.320
Adherens junctions interactions	R-HSA-418990	4.989790e-03	2.302
Host Interactions of HIV factors	R-HSA-162909	5.168465e-03	2.287
Gap junction degradation	R-HSA-190873	5.321711e-03	2.274
Viral Messenger RNA Synthesis	R-HSA-168325	5.373031e-03	2.270
Gene expression (Transcription)	R-HSA-74160	5.392321e-03	2.268
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.447549e-03	2.264
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.601886e-03	2.252
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.815856e-03	2.235
Signaling by TGF-beta Receptor Complex	R-HSA-170834	6.070075e-03	2.217
Regulation of CDH19 Expression and Function	R-HSA-9764302	6.639374e-03	2.178
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.082726e-03	2.216
Signaling by VEGF	R-HSA-194138	6.086983e-03	2.216
Inositol phosphate metabolism	R-HSA-1483249	6.155705e-03	2.211
Regulation of KIT signaling	R-HSA-1433559	6.801286e-03	2.167
Semaphorin interactions	R-HSA-373755	6.810210e-03	2.167
Macroautophagy	R-HSA-1632852	6.872468e-03	2.163
Cellular responses to stimuli	R-HSA-8953897	7.092238e-03	2.149
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.271631e-03	2.138
MTOR signalling	R-HSA-165159	7.271631e-03	2.138
p75 NTR receptor-mediated signalling	R-HSA-193704	7.288242e-03	2.137
Clathrin-mediated endocytosis	R-HSA-8856828	8.552501e-03	2.068
TGFBR3 expression	R-HSA-9839394	8.560409e-03	2.068
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	8.971166e-03	2.047
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	9.398039e-03	2.027
mRNA Splicing - Major Pathway	R-HSA-72163	9.008268e-03	2.045
EPHB-mediated forward signaling	R-HSA-3928662	9.540132e-03	2.020
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	9.907534e-03	2.004
Reproduction	R-HSA-1474165	9.679831e-03	2.014
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	9.480279e-03	2.023
RNA Polymerase II Pre-transcription Events	R-HSA-674695	9.913591e-03	2.004
mRNA 3'-end processing	R-HSA-72187	1.052402e-02	1.978
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.100998e-02	1.958
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.121497e-02	1.950
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.125115e-02	1.949
Regulation of PTEN gene transcription	R-HSA-8943724	1.125115e-02	1.949
Interaction between L1 and Ankyrins	R-HSA-445095	1.208674e-02	1.918
Aggrephagy	R-HSA-9646399	1.260057e-02	1.900
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.303052e-02	1.885
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.476279e-02	1.831
Diseases of Telomere Maintenance	R-HSA-9673013	1.476279e-02	1.831
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.476279e-02	1.831
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.476279e-02	1.831
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.476279e-02	1.831
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.476279e-02	1.831
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.407124e-02	1.852
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.315196e-02	1.881
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.315196e-02	1.881
Developmental Biology	R-HSA-1266738	1.459290e-02	1.836
Deubiquitination	R-HSA-5688426	1.462899e-02	1.835
Transcriptional Regulation by VENTX	R-HSA-8853884	1.437168e-02	1.842
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.462129e-02	1.835
tRNA processing in the nucleus	R-HSA-6784531	1.395664e-02	1.855
Gene Silencing by RNA	R-HSA-211000	1.543782e-02	1.811
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.571930e-02	1.804
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.656709e-02	1.781
TNF signaling	R-HSA-75893	1.656709e-02	1.781
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.679114e-02	1.775
mRNA Splicing	R-HSA-72172	1.697163e-02	1.770
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.824265e-02	1.739
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.824265e-02	1.739
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.824265e-02	1.739
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.824265e-02	1.739
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.862336e-02	1.730
Type I hemidesmosome assembly	R-HSA-446107	1.920218e-02	1.717
Ephrin signaling	R-HSA-3928664	2.034650e-02	1.692
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.169834e-02	1.664
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.922698e-02	1.716
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.922698e-02	1.716
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.083281e-02	1.681
Selective autophagy	R-HSA-9663891	1.902416e-02	1.721
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.105846e-02	1.677
EGFR downregulation	R-HSA-182971	2.216384e-02	1.654
MITF-M-dependent gene expression	R-HSA-9856651	2.371529e-02	1.625
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.509702e-02	1.600
Inactivation of CDC42 and RAC1	R-HSA-428543	2.535501e-02	1.596
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.535501e-02	1.596
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.540364e-02	1.595
Signaling by TGFB family members	R-HSA-9006936	2.543010e-02	1.595
ATP-dependent chromatin remodelers	R-HSA-9932444	2.552026e-02	1.593
SWI/SNF chromatin remodelers	R-HSA-9932451	2.552026e-02	1.593
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.606258e-02	1.584
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.606258e-02	1.584
CRMPs in Sema3A signaling	R-HSA-399956	2.606258e-02	1.584
Meiotic synapsis	R-HSA-1221632	2.700835e-02	1.569
MITF-M-regulated melanocyte development	R-HSA-9730414	2.700916e-02	1.568
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.711240e-02	1.567
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.711240e-02	1.567
RNA Polymerase II Transcription Termination	R-HSA-73856	2.741344e-02	1.562
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.129410e-02	1.505
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.129410e-02	1.505
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.129410e-02	1.505
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.256754e-02	1.487
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.176782e-02	1.498
Amplification of signal from the kinetochores	R-HSA-141424	2.902031e-02	1.537
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.902031e-02	1.537
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.954886e-02	1.529
Regulation of CDH11 function	R-HSA-9762292	3.256754e-02	1.487
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.256754e-02	1.487
FGFR1 mutant receptor activation	R-HSA-1839124	2.895988e-02	1.538
Breakdown of the nuclear lamina	R-HSA-352238	3.129410e-02	1.505
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.008832e-02	1.522
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.811663e-02	1.551
RNA Polymerase II Transcription	R-HSA-73857	3.362532e-02	1.473
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.397441e-02	1.469
Oxidative Stress Induced Senescence	R-HSA-2559580	3.403795e-02	1.468
Signaling by EGFR	R-HSA-177929	3.614217e-02	1.442
RAF activation	R-HSA-5673000	3.707052e-02	1.431
Gap junction assembly	R-HSA-190861	3.707052e-02	1.431
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.789063e-02	1.421
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.789063e-02	1.421
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.789063e-02	1.421
Phosphorylation of the APC/C	R-HSA-176412	3.819679e-02	1.418
MAP2K and MAPK activation	R-HSA-5674135	3.877957e-02	1.411
HIV elongation arrest and recovery	R-HSA-167287	3.884341e-02	1.411
Pausing and recovery of HIV elongation	R-HSA-167290	3.884341e-02	1.411
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	3.923411e-02	1.406
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	3.957116e-02	1.403
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	3.957116e-02	1.403
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.957116e-02	1.403
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.957116e-02	1.403
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	3.957116e-02	1.403
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.060197e-02	1.391
PECAM1 interactions	R-HSA-210990	4.086124e-02	1.389
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.052749e-02	1.296
Transcription of the HIV genome	R-HSA-167172	5.017312e-02	1.300
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.052749e-02	1.296
Meiosis	R-HSA-1500620	5.049372e-02	1.297
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.763505e-02	1.322
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	4.536543e-02	1.343
Nef and signal transduction	R-HSA-164944	5.052749e-02	1.296
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	4.536543e-02	1.343
mTORC1-mediated signalling	R-HSA-166208	4.572018e-02	1.340
MAPK family signaling cascades	R-HSA-5683057	4.474280e-02	1.349
HATs acetylate histones	R-HSA-3214847	4.959881e-02	1.305
Transcriptional regulation by RUNX1	R-HSA-8878171	4.894548e-02	1.310
RUNX2 regulates bone development	R-HSA-8941326	4.658210e-02	1.332
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	4.536543e-02	1.343
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.572018e-02	1.340
Formation of RNA Pol II elongation complex	R-HSA-112382	5.226969e-02	1.282
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.243141e-02	1.280
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.243943e-02	1.280
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.243943e-02	1.280
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.243943e-02	1.280
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.243943e-02	1.280
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.243943e-02	1.280
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.243943e-02	1.280
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.243943e-02	1.280
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.243943e-02	1.280
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.243943e-02	1.280
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.243943e-02	1.280
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.243943e-02	1.280
Regulation of TP53 Expression	R-HSA-6804754	5.243943e-02	1.280
Intracellular signaling by second messengers	R-HSA-9006925	5.253400e-02	1.280
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.423957e-02	1.266
PTEN Regulation	R-HSA-6807070	5.427188e-02	1.265
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.705715e-02	1.244
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.773646e-02	1.239
Deadenylation of mRNA	R-HSA-429947	5.971127e-02	1.224
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.070261e-02	1.217
Repression of WNT target genes	R-HSA-4641265	6.070261e-02	1.217
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.195257e-02	1.208
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.302528e-02	1.200
Cargo trafficking to the periciliary membrane	R-HSA-5620920	6.302528e-02	1.200
Regulation of TNFR1 signaling	R-HSA-5357905	6.326737e-02	1.199
Signaling by TGFBR3	R-HSA-9839373	6.326737e-02	1.199
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.361509e-02	1.196
Regulation of TP53 Expression and Degradation	R-HSA-6806003	6.361509e-02	1.196
HCMV Early Events	R-HSA-9609690	6.449065e-02	1.191
Signaling by FGFR1 amplification mutants	R-HSA-1839120	7.726888e-02	1.112
MET interacts with TNS proteins	R-HSA-8875513	7.726888e-02	1.112
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	7.726888e-02	1.112
RUNX3 regulates WNT signaling	R-HSA-8951430	6.493681e-02	1.188
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.493681e-02	1.188
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.493681e-02	1.188
Signaling by MRAS-complex mutants	R-HSA-9660537	8.100545e-02	1.091
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	8.100545e-02	1.091
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	7.222152e-02	1.141
Germ layer formation at gastrulation	R-HSA-9754189	7.137053e-02	1.146
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	7.137053e-02	1.146
DNA Damage Recognition in GG-NER	R-HSA-5696394	7.735061e-02	1.112
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	6.912335e-02	1.160
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.537751e-02	1.185
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.537751e-02	1.185
Regulation of CDH1 Function	R-HSA-9764561	7.902144e-02	1.102
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.493681e-02	1.188
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	8.100545e-02	1.091
Attenuation phase	R-HSA-3371568	7.005091e-02	1.155
Formation of axial mesoderm	R-HSA-9796292	7.222152e-02	1.141
Long-term potentiation	R-HSA-9620244	6.756264e-02	1.170
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.735061e-02	1.112
Interferon Signaling	R-HSA-913531	7.879573e-02	1.103
VEGFR2 mediated vascular permeability	R-HSA-5218920	7.687020e-02	1.114
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.979187e-02	1.156
Generic Transcription Pathway	R-HSA-212436	7.052293e-02	1.152
FLT3 Signaling	R-HSA-9607240	7.687020e-02	1.114
PKMTs methylate histone lysines	R-HSA-3214841	7.687020e-02	1.114
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	6.979187e-02	1.156
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	8.152768e-02	1.089
Post-chaperonin tubulin folding pathway	R-HSA-389977	8.152768e-02	1.089
Negative regulation of MET activity	R-HSA-6807004	8.152768e-02	1.089
AURKA Activation by TPX2	R-HSA-8854518	8.158725e-02	1.088
Signaling by FGFR1 in disease	R-HSA-5655302	8.407338e-02	1.075
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.497432e-02	1.071
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.497432e-02	1.071
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.536808e-02	1.069
RAF/MAP kinase cascade	R-HSA-5673001	8.648770e-02	1.063
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	8.724718e-02	1.059
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	8.724718e-02	1.059
Interleukin-12 signaling	R-HSA-9020591	8.891759e-02	1.051
EPH-Ephrin signaling	R-HSA-2682334	8.995289e-02	1.046
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	9.240919e-02	1.034
Oncogene Induced Senescence	R-HSA-2559585	9.384103e-02	1.028
Phase 0 - rapid depolarisation	R-HSA-5576892	9.452349e-02	1.024
Developmental Cell Lineages	R-HSA-9734767	9.624161e-02	1.017
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	9.829687e-02	1.007
Sema3A PAK dependent Axon repulsion	R-HSA-399954	9.829687e-02	1.007
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	9.829687e-02	1.007
DCC mediated attractive signaling	R-HSA-418885	9.829687e-02	1.007
Cytokine Signaling in Immune system	R-HSA-1280215	9.854166e-02	1.006
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	9.860106e-02	1.006
AKT phosphorylates targets in the nucleus	R-HSA-198693	9.860106e-02	1.006
Regulation of CDH11 gene transcription	R-HSA-9762293	9.860106e-02	1.006
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	9.860106e-02	1.006
TCR signaling	R-HSA-202403	9.927565e-02	1.003
Signaling by SCF-KIT	R-HSA-1433557	9.962585e-02	1.002
PI Metabolism	R-HSA-1483255	1.001662e-01	0.999
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.046222e-01	0.980
Regulation of gene expression in beta cells	R-HSA-210745	1.046222e-01	0.980
PIP3 activates AKT signaling	R-HSA-1257604	1.047518e-01	0.980
Regulation of gap junction activity	R-HSA-191650	1.049795e-01	0.979
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.049795e-01	0.979
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.049795e-01	0.979
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.049795e-01	0.979
FLT3 signaling through SRC family kinases	R-HSA-9706374	1.049795e-01	0.979
Apoptosis	R-HSA-109581	1.076251e-01	0.968
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.079687e-01	0.967
MAPK1/MAPK3 signaling	R-HSA-5684996	1.080245e-01	0.966
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.111457e-01	0.954
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.111457e-01	0.954
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.121301e-01	0.950
Ovarian tumor domain proteases	R-HSA-5689896	1.121301e-01	0.950
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.348804e-01	0.870
Activation of AKT2	R-HSA-165158	1.348804e-01	0.870
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.348804e-01	0.870
G2 Phase	R-HSA-68911	1.348804e-01	0.870
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.377852e-01	0.861
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.281025e-01	0.892
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.162610e-01	0.935
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.427141e-01	0.846
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.264126e-01	0.898
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	1.427843e-01	0.845
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.427843e-01	0.845
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.257614e-01	0.900
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.351967e-01	0.869
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.449795e-01	0.839
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.283043e-01	0.892
Centrosome maturation	R-HSA-380287	1.438905e-01	0.842
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.262949e-01	0.899
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	1.442583e-01	0.841
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.502086e-01	0.823
Epigenetic regulation of gene expression	R-HSA-212165	1.329468e-01	0.876
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.377852e-01	0.861
TCF dependent signaling in response to WNT	R-HSA-201681	1.201481e-01	0.920
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.348804e-01	0.870
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	1.285255e-01	0.891
Downregulation of ERBB2 signaling	R-HSA-8863795	1.152572e-01	0.938
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.291781e-01	0.889
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.208761e-01	0.918
Circadian clock	R-HSA-9909396	1.387650e-01	0.858
Estrogen-dependent gene expression	R-HSA-9018519	1.144765e-01	0.941
Heme signaling	R-HSA-9707616	1.129197e-01	0.947
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.348804e-01	0.870
Negative regulation of FLT3	R-HSA-9706369	1.127611e-01	0.948
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.129197e-01	0.947
COPI-mediated anterograde transport	R-HSA-6807878	1.184673e-01	0.926
Metabolism of RNA	R-HSA-8953854	1.155890e-01	0.937
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.502086e-01	0.823
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.291781e-01	0.889
Nuclear RNA decay	R-HSA-9930044	1.502086e-01	0.823
Mitotic G2-G2/M phases	R-HSA-453274	1.438087e-01	0.842
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.281025e-01	0.892
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.455682e-01	0.837
Glycolysis	R-HSA-70171	1.446643e-01	0.840
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.127611e-01	0.948
SARS-CoV-2-host interactions	R-HSA-9705683	1.516500e-01	0.819
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.527275e-01	0.816
Degradation of CDH1	R-HSA-9766229	1.550996e-01	0.809
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.550996e-01	0.809
DNA Damage Bypass	R-HSA-73893	1.550996e-01	0.809
Tight junction interactions	R-HSA-420029	1.568334e-01	0.805
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	1.568334e-01	0.805
Sema4D in semaphorin signaling	R-HSA-400685	1.568334e-01	0.805
Signaling by AMER1 mutants	R-HSA-4839748	1.590652e-01	0.798
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.590652e-01	0.798
Signaling by GSK3beta mutants	R-HSA-5339716	1.590652e-01	0.798
Chaperone Mediated Autophagy	R-HSA-9613829	1.611615e-01	0.793
HCMV Infection	R-HSA-9609646	1.615544e-01	0.792
Resolution of D-Loop Structures	R-HSA-5693537	1.628057e-01	0.788
Deadenylation-dependent mRNA decay	R-HSA-429914	1.645745e-01	0.784
Regulation of beta-cell development	R-HSA-186712	1.645745e-01	0.784
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	1.652203e-01	0.782
HIV Transcription Initiation	R-HSA-167161	1.652203e-01	0.782
RNA Polymerase II Transcription Initiation	R-HSA-75953	1.652203e-01	0.782
Regulation of RAS by GAPs	R-HSA-5658442	1.655456e-01	0.781
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.657850e-01	0.780
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.663789e-01	0.779
PKB-mediated events	R-HSA-109703	1.663789e-01	0.779
PDE3B signalling	R-HSA-165160	1.663789e-01	0.779
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.663789e-01	0.779
Sodium-coupled phosphate cotransporters	R-HSA-427652	1.663789e-01	0.779
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.663789e-01	0.779
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.663789e-01	0.779
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.668870e-01	0.778
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.668870e-01	0.778
Formation of editosomes by ADAR proteins	R-HSA-77042	1.668870e-01	0.778
Inhibition of PKR	R-HSA-169131	1.668870e-01	0.778
SDK interactions	R-HSA-373756	1.668870e-01	0.778
Interactions of Tat with host cellular proteins	R-HSA-176034	2.395824e-01	0.621
Defective SLC34A2 causes PALM	R-HSA-5687583	2.395824e-01	0.621
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	R-HSA-5619045	2.395824e-01	0.621
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.395824e-01	0.621
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.395824e-01	0.621
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.989693e-01	0.701
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.989693e-01	0.701
IFNG signaling activates MAPKs	R-HSA-9732724	2.322215e-01	0.634
Disinhibition of SNARE formation	R-HSA-114516	2.322215e-01	0.634
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.812628e-01	0.742
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.812628e-01	0.742
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.812628e-01	0.742
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.812628e-01	0.742
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.812628e-01	0.742
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.812628e-01	0.742
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.812628e-01	0.742
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.812628e-01	0.742
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.042250e-01	0.690
Regulation of signaling by CBL	R-HSA-912631	1.787420e-01	0.748
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.787420e-01	0.748
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	2.278040e-01	0.642
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.969278e-01	0.706
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.969278e-01	0.706
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.969278e-01	0.706
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.969278e-01	0.706
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.969278e-01	0.706
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.969278e-01	0.706
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	2.518581e-01	0.599
Beta-catenin phosphorylation cascade	R-HSA-196299	2.518581e-01	0.599
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.156456e-01	0.666
Late endosomal microautophagy	R-HSA-9615710	2.183518e-01	0.661
RNA Polymerase II Promoter Escape	R-HSA-73776	1.891069e-01	0.723
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.744976e-01	0.758
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	2.142945e-01	0.669
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.465420e-01	0.608
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.406185e-01	0.619
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.222000e-01	0.653
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.343120e-01	0.630
Transcriptional regulation by RUNX3	R-HSA-8878159	1.946103e-01	0.711
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.814425e-01	0.741
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.347792e-01	0.629
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.866674e-01	0.729
Signaling by ERBB2	R-HSA-1227986	1.744976e-01	0.758
Nephrin family interactions	R-HSA-373753	1.969278e-01	0.706
UCH proteinases	R-HSA-5689603	2.427344e-01	0.615
VxPx cargo-targeting to cilium	R-HSA-5620916	1.969278e-01	0.706
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.348223e-01	0.629
Myogenesis	R-HSA-525793	1.714980e-01	0.766
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.030943e-01	0.692
RNA Polymerase III Transcription	R-HSA-74158	2.030943e-01	0.692
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	2.183518e-01	0.661
Trafficking of AMPA receptors	R-HSA-399719	2.515374e-01	0.599
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.866674e-01	0.729
PTK6 Expression	R-HSA-8849473	2.322215e-01	0.634
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.787420e-01	0.748
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.518581e-01	0.599
Signaling by WNT	R-HSA-195721	1.983287e-01	0.703
Calmodulin induced events	R-HSA-111933	2.030943e-01	0.692
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	1.989693e-01	0.701
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.278040e-01	0.642
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.714980e-01	0.766
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.246468e-01	0.648
Signaling by NODAL	R-HSA-1181150	1.969278e-01	0.706
CaM pathway	R-HSA-111997	2.030943e-01	0.692
HSF1 activation	R-HSA-3371511	2.030943e-01	0.692
DAG and IP3 signaling	R-HSA-1489509	2.142945e-01	0.669
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.222000e-01	0.653
Cilium Assembly	R-HSA-5617833	2.109313e-01	0.676
p75NTR recruits signalling complexes	R-HSA-209543	1.812628e-01	0.742
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.347792e-01	0.629
Signal transduction by L1	R-HSA-445144	1.969278e-01	0.706
p75NTR signals via NF-kB	R-HSA-193639	2.518581e-01	0.599
Transport of connexins along the secretory pathway	R-HSA-190827	2.395824e-01	0.621
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.518581e-01	0.599
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	2.465420e-01	0.608
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.103274e-01	0.677
Signaling by PTK6	R-HSA-8848021	2.058244e-01	0.687
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.058244e-01	0.687
Golgi-to-ER retrograde transport	R-HSA-8856688	2.023745e-01	0.694
Vesicle-mediated transport	R-HSA-5653656	2.084943e-01	0.681
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.518581e-01	0.599
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.866674e-01	0.729
TBC/RABGAPs	R-HSA-8854214	1.891069e-01	0.723
Rab regulation of trafficking	R-HSA-9007101	2.234951e-01	0.651
Ub-specific processing proteases	R-HSA-5689880	2.314860e-01	0.635
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.022998e-01	0.694
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.105878e-01	0.677
Oligomerization of connexins into connexons	R-HSA-190704	2.395824e-01	0.621
Protein methylation	R-HSA-8876725	2.518581e-01	0.599
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	2.518581e-01	0.599
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.250309e-01	0.648
Signaling by FGFR in disease	R-HSA-1226099	2.215006e-01	0.655
Cell Cycle Checkpoints	R-HSA-69620	2.014826e-01	0.696
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	2.322215e-01	0.634
G2/M Transition	R-HSA-69275	2.513327e-01	0.600
Netrin-1 signaling	R-HSA-373752	2.015480e-01	0.696
MHC class II antigen presentation	R-HSA-2132295	1.936213e-01	0.713
Regulation of TP53 Degradation	R-HSA-6804757	2.030943e-01	0.692
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.866674e-01	0.729
Interleukin-12 family signaling	R-HSA-447115	1.740610e-01	0.759
Co-stimulation by CD28	R-HSA-389356	2.541523e-01	0.595
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.543852e-01	0.595
ESR-mediated signaling	R-HSA-8939211	2.569485e-01	0.590
Adaptive Immune System	R-HSA-1280218	2.584217e-01	0.588
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.059385e-01	0.514
Regulation of cortical dendrite branching	R-HSA-8985801	3.059385e-01	0.514
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.059385e-01	0.514
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.059385e-01	0.514
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.059385e-01	0.514
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.059385e-01	0.514
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.059385e-01	0.514
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.059385e-01	0.514
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.665078e-01	0.436
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	3.665078e-01	0.436
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	3.665078e-01	0.436
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.665078e-01	0.436
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.665078e-01	0.436
Regulation of NPAS4 mRNA translation	R-HSA-9768778	2.657723e-01	0.575
ARMS-mediated activation	R-HSA-170984	2.993167e-01	0.524
Lipophagy	R-HSA-9613354	2.993167e-01	0.524
WNT mediated activation of DVL	R-HSA-201688	2.993167e-01	0.524
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	2.993167e-01	0.524
ALK mutants bind TKIs	R-HSA-9700645	2.993167e-01	0.524
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.217946e-01	0.375
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.762538e-01	0.559
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	2.762538e-01	0.559
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.762538e-01	0.559
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	3.654142e-01	0.437
Signaling by APC mutants	R-HSA-4839744	3.654142e-01	0.437
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.654142e-01	0.437
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.654142e-01	0.437
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.654142e-01	0.437
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	4.722593e-01	0.326
IRS activation	R-HSA-74713	4.722593e-01	0.326
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	4.722593e-01	0.326
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	4.722593e-01	0.326
FLT3 signaling by CBL mutants	R-HSA-9706377	4.722593e-01	0.326
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.722593e-01	0.326
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.255774e-01	0.487
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	3.975862e-01	0.401
Signaling by activated point mutants of FGFR1	R-HSA-1839122	3.975862e-01	0.401
Activation of RAC1	R-HSA-428540	3.975862e-01	0.401
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.502822e-01	0.456
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.146866e-01	0.502
HIV Transcription Elongation	R-HSA-167169	2.615881e-01	0.582
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.615881e-01	0.582
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.615881e-01	0.582
Striated Muscle Contraction	R-HSA-390522	3.033517e-01	0.518
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.748823e-01	0.426
RUNX3 regulates p14-ARF	R-HSA-8951936	4.289789e-01	0.368
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.289789e-01	0.368
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	2.591871e-01	0.586
EPHA-mediated growth cone collapse	R-HSA-3928663	3.555674e-01	0.449
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.594833e-01	0.338
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.594833e-01	0.338
CD28 dependent Vav1 pathway	R-HSA-389359	4.594833e-01	0.338
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.594833e-01	0.338
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	3.102385e-01	0.508
PRC2 methylates histones and DNA	R-HSA-212300	3.565638e-01	0.448
IRS-related events triggered by IGF1R	R-HSA-2428928	2.978667e-01	0.526
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.246331e-01	0.489
HDACs deacetylate histones	R-HSA-3214815	3.537104e-01	0.451
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.167140e-01	0.380
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.167140e-01	0.380
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	4.472162e-01	0.349
NRIF signals cell death from the nucleus	R-HSA-205043	4.890155e-01	0.311
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.890155e-01	0.311
FGFR2 alternative splicing	R-HSA-6803529	4.706034e-01	0.327
Notch-HLH transcription pathway	R-HSA-350054	4.706034e-01	0.327
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.693748e-01	0.433
Erythropoietin activates RAS	R-HSA-9027284	5.175127e-01	0.286
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.175127e-01	0.286
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.175127e-01	0.286
PI3K Cascade	R-HSA-109704	4.356909e-01	0.361
Regulation of PTEN mRNA translation	R-HSA-8943723	4.935319e-01	0.307
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.159552e-01	0.287
Amino acids regulate mTORC1	R-HSA-9639288	4.829727e-01	0.316
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.829727e-01	0.316
Translation initiation complex formation	R-HSA-72649	4.984714e-01	0.302
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	5.132729e-01	0.290
Regulation of endogenous retroelements	R-HSA-9842860	3.393278e-01	0.469
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.986372e-01	0.525
Regulation of mitotic cell cycle	R-HSA-453276	2.986372e-01	0.525
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.719157e-01	0.566
RNA Polymerase III Transcription Initiation	R-HSA-76046	4.167140e-01	0.380
Nucleotide Excision Repair	R-HSA-5696398	5.017844e-01	0.299
Integrin signaling	R-HSA-354192	2.858678e-01	0.544
Adipogenesis	R-HSA-9843745	2.739274e-01	0.562
KEAP1-NFE2L2 pathway	R-HSA-9755511	4.758497e-01	0.323
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.278081e-01	0.369
DNA Double Strand Break Response	R-HSA-5693606	3.783811e-01	0.422
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.766821e-01	0.558
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.512420e-01	0.454
DNA Double-Strand Break Repair	R-HSA-5693532	3.040758e-01	0.517
IGF1R signaling cascade	R-HSA-2428924	3.377588e-01	0.471
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	4.629164e-01	0.334
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	5.149353e-01	0.288
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	3.336554e-01	0.477
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.986372e-01	0.525
Homology Directed Repair	R-HSA-5693538	4.297677e-01	0.367
G0 and Early G1	R-HSA-1538133	4.567658e-01	0.340
EGFR Transactivation by Gastrin	R-HSA-2179392	3.326006e-01	0.478
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.764466e-01	0.322
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.159552e-01	0.287
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.806949e-01	0.318
GAB1 signalosome	R-HSA-180292	3.502822e-01	0.456
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.762538e-01	0.559
Synthesis of PIPs at the ER membrane	R-HSA-1483248	3.654142e-01	0.437
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	4.706034e-01	0.327
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.110533e-01	0.507
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.124210e-01	0.505
Degradation of CRY and PER proteins	R-HSA-9932298	4.629164e-01	0.334
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.149353e-01	0.288
Generation of second messenger molecules	R-HSA-202433	2.615881e-01	0.582
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	2.657723e-01	0.575
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	4.722593e-01	0.326
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.615881e-01	0.582
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.959702e-01	0.529
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	4.935319e-01	0.307
Prolonged ERK activation events	R-HSA-169893	2.762538e-01	0.559
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.102143e-01	0.508
Neddylation	R-HSA-8951664	4.436444e-01	0.353
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.562376e-01	0.341
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.905410e-01	0.309
Activation of HOX genes during differentiation	R-HSA-5619507	4.905410e-01	0.309
Negative regulation of MAPK pathway	R-HSA-5675221	2.923409e-01	0.534
Adrenoceptors	R-HSA-390696	2.657723e-01	0.575
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.008656e-01	0.522
Formation of the posterior neural plate	R-HSA-9832991	3.654142e-01	0.437
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	2.742628e-01	0.562
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.748823e-01	0.426
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	4.890155e-01	0.311
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.802338e-01	0.319
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.149353e-01	0.288
Signaling by NOTCH3	R-HSA-9012852	3.537104e-01	0.451
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.625157e-01	0.581
Beta-catenin independent WNT signaling	R-HSA-3858494	4.260442e-01	0.371
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.102385e-01	0.508
Signaling by WNT in cancer	R-HSA-4791275	4.567658e-01	0.340
Frs2-mediated activation	R-HSA-170968	4.594833e-01	0.338
Regulation of T cell activation by CD28 family	R-HSA-388841	3.126191e-01	0.505
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.255774e-01	0.487
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.555674e-01	0.449
Co-inhibition by CTLA4	R-HSA-389513	3.992893e-01	0.399
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.922683e-01	0.406
Negative regulation of FGFR1 signaling	R-HSA-5654726	4.764466e-01	0.322
G-protein beta:gamma signalling	R-HSA-397795	4.764466e-01	0.322
PLC beta mediated events	R-HSA-112043	2.978667e-01	0.526
Co-inhibition by PD-1	R-HSA-389948	3.550324e-01	0.450
trans-Golgi Network Vesicle Budding	R-HSA-199992	3.109440e-01	0.507
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.387411e-01	0.470
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.289789e-01	0.368
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.748823e-01	0.426
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	4.368416e-01	0.360
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.749646e-01	0.561
Ca-dependent events	R-HSA-111996	3.079860e-01	0.511
DNA Repair	R-HSA-73894	3.071974e-01	0.513
Gastrulation	R-HSA-9758941	2.714253e-01	0.566
mRNA Editing: A to I Conversion	R-HSA-75064	3.059385e-01	0.514
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.059385e-01	0.514
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.059385e-01	0.514
C6 deamination of adenosine	R-HSA-75102	3.059385e-01	0.514
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.059385e-01	0.514
Type II Na+/Pi cotransporters	R-HSA-427589	3.665078e-01	0.436
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.657723e-01	0.575
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.326006e-01	0.478
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	2.762538e-01	0.559
Disorders of Developmental Biology	R-HSA-9675151	3.008656e-01	0.522
Bicarbonate transporters	R-HSA-425381	3.654142e-01	0.437
Reelin signalling pathway	R-HSA-8866376	4.722593e-01	0.326
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.943857e-01	0.531
Signaling by AXIN mutants	R-HSA-4839735	3.975862e-01	0.401
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.502822e-01	0.456
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.146866e-01	0.502
Membrane binding and targetting of GAG proteins	R-HSA-174490	4.594833e-01	0.338
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.594833e-01	0.338
Budding and maturation of HIV virion	R-HSA-162588	4.368416e-01	0.360
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.912610e-01	0.536
Intraflagellar transport	R-HSA-5620924	4.037336e-01	0.394
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.149353e-01	0.288
Ca2+ pathway	R-HSA-4086398	4.599697e-01	0.337
G-protein mediated events	R-HSA-112040	3.783811e-01	0.422
Neurodegenerative Diseases	R-HSA-8863678	2.943857e-01	0.531
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.943857e-01	0.531
Spry regulation of FGF signaling	R-HSA-1295596	5.175127e-01	0.286
Cellular response to hypoxia	R-HSA-1234174	4.993556e-01	0.302
Smooth Muscle Contraction	R-HSA-445355	3.246331e-01	0.489
Hedgehog 'off' state	R-HSA-5610787	4.336389e-01	0.363
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.208307e-01	0.494
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.882392e-01	0.311
Cellular responses to mechanical stimuli	R-HSA-9855142	4.806949e-01	0.318
MAPK6/MAPK4 signaling	R-HSA-5687128	3.454996e-01	0.462
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.555674e-01	0.449
Muscle contraction	R-HSA-397014	2.965652e-01	0.528
Ion homeostasis	R-HSA-5578775	3.683485e-01	0.434
Protein ubiquitination	R-HSA-8852135	3.484607e-01	0.458
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.993167e-01	0.524
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.217946e-01	0.375
Muscarinic acetylcholine receptors	R-HSA-390648	4.722593e-01	0.326
Disorders of Nervous System Development	R-HSA-9697154	4.289789e-01	0.368
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.289789e-01	0.368
Pervasive developmental disorders	R-HSA-9005895	4.289789e-01	0.368
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	4.890155e-01	0.311
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	4.890155e-01	0.311
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.706034e-01	0.327
Signaling by Activin	R-HSA-1502540	5.175127e-01	0.286
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	5.175127e-01	0.286
Organelle biogenesis and maintenance	R-HSA-1852241	3.192506e-01	0.496
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	3.351010e-01	0.475
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.289789e-01	0.368
Activation of BH3-only proteins	R-HSA-114452	4.167140e-01	0.380
Regulation of NPAS4 gene expression	R-HSA-9768759	3.255774e-01	0.487
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	4.368416e-01	0.360
Platelet degranulation	R-HSA-114608	4.228471e-01	0.374
HDMs demethylate histones	R-HSA-3214842	3.146866e-01	0.502
Ion transport by P-type ATPases	R-HSA-936837	3.377588e-01	0.471
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	4.579135e-01	0.339
GP1b-IX-V activation signalling	R-HSA-430116	2.993167e-01	0.524
Cellular response to mitochondrial stress	R-HSA-9840373	2.993167e-01	0.524
TNFR1-mediated ceramide production	R-HSA-5626978	4.217946e-01	0.375
Josephin domain DUBs	R-HSA-5689877	3.326006e-01	0.478
Inositol transporters	R-HSA-429593	4.722593e-01	0.326
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.858678e-01	0.544
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.234241e-01	0.373
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.234241e-01	0.373
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.233302e-01	0.490
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.562376e-01	0.341
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.159552e-01	0.287
Signaling by NOTCH1	R-HSA-1980143	5.000917e-01	0.301
TP53 Regulates Metabolic Genes	R-HSA-5628897	2.851303e-01	0.545
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.878320e-01	0.411
MET activates RAS signaling	R-HSA-8851805	4.289789e-01	0.368
Basigin interactions	R-HSA-210991	4.234241e-01	0.373
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.876957e-01	0.412
Switching of origins to a post-replicative state	R-HSA-69052	4.599697e-01	0.337
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.657723e-01	0.575
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.890155e-01	0.311
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.454316e-01	0.351
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	3.555674e-01	0.449
Syndecan interactions	R-HSA-3000170	2.742628e-01	0.562
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	3.255774e-01	0.487
Mitophagy	R-HSA-5205647	5.149353e-01	0.288
Signaling by MET	R-HSA-6806834	2.871835e-01	0.542
Regulation of HMOX1 expression and activity	R-HSA-9707587	4.217946e-01	0.375
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	4.764466e-01	0.322
Potential therapeutics for SARS	R-HSA-9679191	4.664936e-01	0.331
Non-integrin membrane-ECM interactions	R-HSA-3000171	4.868056e-01	0.313
Interleukin-7 signaling	R-HSA-1266695	3.146866e-01	0.502
RMTs methylate histone arginines	R-HSA-3214858	3.396614e-01	0.469
S Phase	R-HSA-69242	4.477313e-01	0.349
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.802338e-01	0.319
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.654142e-01	0.437
Signal regulatory protein family interactions	R-HSA-391160	4.890155e-01	0.311
Formation of the anterior neural plate	R-HSA-9823739	5.175127e-01	0.286
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.175127e-01	0.286
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.959734e-01	0.529
Influenza Infection	R-HSA-168255	3.552260e-01	0.449
Signaling by ALK in cancer	R-HSA-9700206	2.959734e-01	0.529
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.175127e-01	0.286
Interleukin-1 family signaling	R-HSA-446652	3.861623e-01	0.413
Assembly of the pre-replicative complex	R-HSA-68867	4.656492e-01	0.332
Programmed Cell Death	R-HSA-5357801	4.021824e-01	0.396
Signaling by PDGFR in disease	R-HSA-9671555	4.472162e-01	0.349
Physiological factors	R-HSA-5578768	4.890155e-01	0.311
Interleukin-2 signaling	R-HSA-9020558	3.654142e-01	0.437
Transcriptional Regulation by MECP2	R-HSA-8986944	4.296004e-01	0.367
OAS antiviral response	R-HSA-8983711	4.289789e-01	0.368
Nectin/Necl trans heterodimerization	R-HSA-420597	4.722593e-01	0.326
Glucose metabolism	R-HSA-70326	3.136568e-01	0.504
Other semaphorin interactions	R-HSA-416700	5.175127e-01	0.286
Signaling by Interleukins	R-HSA-449147	5.168773e-01	0.287
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.149353e-01	0.288
Cam-PDE 1 activation	R-HSA-111957	5.183224e-01	0.285
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.183224e-01	0.285
Noncanonical activation of NOTCH3	R-HSA-9017802	5.183224e-01	0.285
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.183224e-01	0.285
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.183224e-01	0.285
Phosphorylation of Emi1	R-HSA-176417	5.183224e-01	0.285
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.183224e-01	0.285
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	5.183224e-01	0.285
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	5.183224e-01	0.285
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	5.183224e-01	0.285
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.183224e-01	0.285
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.183224e-01	0.285
Signalling to p38 via RIT and RIN	R-HSA-187706	5.183224e-01	0.285
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.183224e-01	0.285
SLC transporter disorders	R-HSA-5619102	5.219562e-01	0.282
PCP/CE pathway	R-HSA-4086400	5.263371e-01	0.279
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.274839e-01	0.278
Ribosomal scanning and start codon recognition	R-HSA-72702	5.289602e-01	0.277
Asymmetric localization of PCP proteins	R-HSA-4608870	5.309275e-01	0.275
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.309275e-01	0.275
HCMV Late Events	R-HSA-9610379	5.313309e-01	0.275
Regulation of Apoptosis	R-HSA-169911	5.336811e-01	0.273
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.336811e-01	0.273
Signalling to ERKs	R-HSA-187687	5.336811e-01	0.273
PERK regulates gene expression	R-HSA-381042	5.336811e-01	0.273
MicroRNA (miRNA) biogenesis	R-HSA-203927	5.378339e-01	0.269
ER to Golgi Anterograde Transport	R-HSA-199977	5.412844e-01	0.267
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.413196e-01	0.267
IRS-mediated signalling	R-HSA-112399	5.439160e-01	0.264
Killing mechanisms	R-HSA-9664420	5.449307e-01	0.264
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.449307e-01	0.264
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	5.449307e-01	0.264
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	5.473309e-01	0.262
Downstream TCR signaling	R-HSA-202424	5.496907e-01	0.260
GPVI-mediated activation cascade	R-HSA-114604	5.520587e-01	0.258
FLT3 signaling in disease	R-HSA-9682385	5.520587e-01	0.258
Signaling by ROBO receptors	R-HSA-376176	5.539550e-01	0.257
Transcriptional regulation by RUNX2	R-HSA-8878166	5.549894e-01	0.256
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.586586e-01	0.253
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.591351e-01	0.252
Metalloprotease DUBs	R-HSA-5689901	5.591351e-01	0.252
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.591351e-01	0.252
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.603673e-01	0.252
Signaling by LTK in cancer	R-HSA-9842640	5.603673e-01	0.252
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.603673e-01	0.252
Chylomicron clearance	R-HSA-8964026	5.603673e-01	0.252
Erythropoietin activates STAT5	R-HSA-9027283	5.603673e-01	0.252
Autointegration results in viral DNA circles	R-HSA-177539	5.603673e-01	0.252
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.603673e-01	0.252
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	5.603673e-01	0.252
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.603673e-01	0.252
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.603673e-01	0.252
CREB phosphorylation	R-HSA-199920	5.603673e-01	0.252
Processing of DNA double-strand break ends	R-HSA-5693607	5.647165e-01	0.248
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.647165e-01	0.248
Degradation of DVL	R-HSA-4641258	5.700452e-01	0.244
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.712409e-01	0.243
Acetylcholine regulates insulin secretion	R-HSA-399997	5.712409e-01	0.243
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.712409e-01	0.243
Synthesis of PG	R-HSA-1483148	5.712409e-01	0.243
SARS-CoV-2 Infection	R-HSA-9694516	5.713307e-01	0.243
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	5.798323e-01	0.237
Insulin processing	R-HSA-264876	5.798323e-01	0.237
Class I MHC mediated antigen processing & presentation	R-HSA-983169	5.811796e-01	0.236
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	5.872363e-01	0.231
SLC-mediated transport of inorganic anions	R-HSA-9958790	5.876210e-01	0.231
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	5.876210e-01	0.231
Cytoprotection by HMOX1	R-HSA-9707564	5.895253e-01	0.229
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.948524e-01	0.226
PI3K events in ERBB2 signaling	R-HSA-1963642	5.964276e-01	0.224
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	5.964276e-01	0.224
Signaling by EGFRvIII in Cancer	R-HSA-5637812	5.964276e-01	0.224
Constitutive Signaling by EGFRvIII	R-HSA-5637810	5.964276e-01	0.224
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	5.964276e-01	0.224
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	5.987445e-01	0.223
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	5.987445e-01	0.223
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	5.987445e-01	0.223
Recycling of eIF2:GDP	R-HSA-72731	5.987445e-01	0.223
SOS-mediated signalling	R-HSA-112412	5.987445e-01	0.223
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	5.987445e-01	0.223
NOSTRIN mediated eNOS trafficking	R-HSA-203641	5.987445e-01	0.223
Activated NTRK2 signals through CDK5	R-HSA-9032845	5.987445e-01	0.223
VLDL clearance	R-HSA-8964046	5.987445e-01	0.223
Regulation of PTEN localization	R-HSA-8948747	5.987445e-01	0.223
Nef Mediated CD4 Down-regulation	R-HSA-167590	5.987445e-01	0.223
Uptake and function of diphtheria toxin	R-HSA-5336415	5.987445e-01	0.223
CHL1 interactions	R-HSA-447041	5.987445e-01	0.223
Displacement of DNA glycosylase by APEX1	R-HSA-110357	5.987445e-01	0.223
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.987445e-01	0.223
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.999044e-01	0.222
Formation of the Early Elongation Complex	R-HSA-113418	5.999044e-01	0.222
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	5.999044e-01	0.222
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	5.999044e-01	0.222
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.016700e-01	0.221
Response of endothelial cells to shear stress	R-HSA-9860931	6.032696e-01	0.219
Signaling by ALK	R-HSA-201556	6.047695e-01	0.218
SARS-CoV Infections	R-HSA-9679506	6.072945e-01	0.217
Transmission across Chemical Synapses	R-HSA-112315	6.183571e-01	0.209
Signaling by ERBB2 KD Mutants	R-HSA-9664565	6.193355e-01	0.208
Impaired BRCA2 binding to RAD51	R-HSA-9709570	6.193355e-01	0.208
Termination of translesion DNA synthesis	R-HSA-5656169	6.193355e-01	0.208
Platelet calcium homeostasis	R-HSA-418360	6.193355e-01	0.208
G2/M DNA damage checkpoint	R-HSA-69473	6.203886e-01	0.207
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.204866e-01	0.207
FGFR1 ligand binding and activation	R-HSA-190242	6.204866e-01	0.207
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.204866e-01	0.207
RNA Polymerase III Transcription Termination	R-HSA-73980	6.204866e-01	0.207
Nephron development	R-HSA-9831926	6.204866e-01	0.207
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.214765e-01	0.207
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.214765e-01	0.207
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.245511e-01	0.204
Activation of NF-kappaB in B cells	R-HSA-1169091	6.248459e-01	0.204
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	6.249779e-01	0.204
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	6.249779e-01	0.204
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	6.249779e-01	0.204
Viral Infection Pathways	R-HSA-9824446	6.260206e-01	0.203
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.287278e-01	0.202
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.337737e-01	0.198
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.337737e-01	0.198
FGFR1b ligand binding and activation	R-HSA-190370	6.337737e-01	0.198
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.337737e-01	0.198
ROBO receptors bind AKAP5	R-HSA-9010642	6.337737e-01	0.198
Downregulation of ERBB4 signaling	R-HSA-1253288	6.337737e-01	0.198
Alpha-defensins	R-HSA-1462054	6.337737e-01	0.198
Sodium/Proton exchangers	R-HSA-425986	6.337737e-01	0.198
RSK activation	R-HSA-444257	6.337737e-01	0.198
DAP12 signaling	R-HSA-2424491	6.381143e-01	0.195
GABA synthesis, release, reuptake and degradation	R-HSA-888590	6.381143e-01	0.195
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.393570e-01	0.194
Insulin receptor signalling cascade	R-HSA-74751	6.419404e-01	0.193
Rap1 signalling	R-HSA-392517	6.434227e-01	0.192
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.434227e-01	0.192
Specification of the neural plate border	R-HSA-9834899	6.434227e-01	0.192
Translesion Synthesis by POLH	R-HSA-110320	6.434227e-01	0.192
STING mediated induction of host immune responses	R-HSA-1834941	6.434227e-01	0.192
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.450153e-01	0.190
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.451569e-01	0.190
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.482165e-01	0.188
Mitochondrial biogenesis	R-HSA-1592230	6.492647e-01	0.188
Regulation of PTEN stability and activity	R-HSA-8948751	6.535148e-01	0.185
Signaling by Nuclear Receptors	R-HSA-9006931	6.550364e-01	0.184
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	6.562339e-01	0.183
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	6.562339e-01	0.183
Evasion by RSV of host interferon responses	R-HSA-9833109	6.562339e-01	0.183
Molecules associated with elastic fibres	R-HSA-2129379	6.562339e-01	0.183
Signaling by Hedgehog	R-HSA-5358351	6.571011e-01	0.182
Diseases of programmed cell death	R-HSA-9645723	6.595119e-01	0.181
Regulation of PD-L1(CD274) translation	R-HSA-9909620	6.652487e-01	0.177
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.652487e-01	0.177
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.652487e-01	0.177
Common Pathway of Fibrin Clot Formation	R-HSA-140875	6.652487e-01	0.177
DNA Replication Pre-Initiation	R-HSA-69002	6.652663e-01	0.177
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	6.657468e-01	0.177
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.657468e-01	0.177
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.657468e-01	0.177
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.657468e-01	0.177
Calcineurin activates NFAT	R-HSA-2025928	6.657468e-01	0.177
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.657468e-01	0.177
p75NTR regulates axonogenesis	R-HSA-193697	6.657468e-01	0.177
mRNA Editing	R-HSA-75072	6.657468e-01	0.177
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	6.657468e-01	0.177
Regulation of signaling by NODAL	R-HSA-1433617	6.657468e-01	0.177
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.657468e-01	0.177
Respiratory syncytial virus genome replication	R-HSA-9834752	6.657468e-01	0.177
Platelet activation, signaling and aggregation	R-HSA-76002	6.665409e-01	0.176
Signaling by NOTCH	R-HSA-157118	6.684917e-01	0.175
RNA Polymerase I Transcription	R-HSA-73864	6.686816e-01	0.175
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.736910e-01	0.172
MyD88-independent TLR4 cascade	R-HSA-166166	6.750362e-01	0.171
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.750362e-01	0.171
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.801422e-01	0.167
Sensory processing of sound	R-HSA-9659379	6.801422e-01	0.167
Defective pyroptosis	R-HSA-9710421	6.837011e-01	0.165
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	6.859835e-01	0.164
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	6.859835e-01	0.164
Early Phase of HIV Life Cycle	R-HSA-162594	6.859835e-01	0.164
Cardiac conduction	R-HSA-5576891	6.890119e-01	0.162
Cardiogenesis	R-HSA-9733709	6.904858e-01	0.161
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.904858e-01	0.161
Pre-NOTCH Transcription and Translation	R-HSA-1912408	6.917170e-01	0.160
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.938100e-01	0.159
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.949302e-01	0.158
Folding of actin by CCT/TriC	R-HSA-390450	6.949302e-01	0.158
PI3K/AKT activation	R-HSA-198203	6.949302e-01	0.158
Binding and entry of HIV virion	R-HSA-173107	6.949302e-01	0.158
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	6.949302e-01	0.158
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	6.949302e-01	0.158
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	6.949302e-01	0.158
Signal attenuation	R-HSA-74749	6.949302e-01	0.158
MET activates RAP1 and RAC1	R-HSA-8875555	6.949302e-01	0.158
Formation of intermediate mesoderm	R-HSA-9761174	6.949302e-01	0.158
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.949302e-01	0.158
2-LTR circle formation	R-HSA-164843	6.949302e-01	0.158
Pexophagy	R-HSA-9664873	6.949302e-01	0.158
Receptor Mediated Mitophagy	R-HSA-8934903	6.949302e-01	0.158
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	6.949302e-01	0.158
Signaling by Leptin	R-HSA-2586552	6.949302e-01	0.158
G1 Phase	R-HSA-69236	6.980786e-01	0.156
Cyclin D associated events in G1	R-HSA-69231	6.980786e-01	0.156
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	7.056512e-01	0.151
Assembly Of The HIV Virion	R-HSA-175474	7.056512e-01	0.151
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.066216e-01	0.151
Fanconi Anemia Pathway	R-HSA-6783310	7.119805e-01	0.148
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.150400e-01	0.146
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.150400e-01	0.146
Cyclin E associated events during G1/S transition	R-HSA-69202	7.150400e-01	0.146
Opioid Signalling	R-HSA-111885	7.212934e-01	0.142
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.215672e-01	0.142
Presynaptic depolarization and calcium channel opening	R-HSA-112308	7.215672e-01	0.142
LGI-ADAM interactions	R-HSA-5682910	7.215672e-01	0.142
vRNA Synthesis	R-HSA-192814	7.215672e-01	0.142
RHOBTB3 ATPase cycle	R-HSA-9706019	7.215672e-01	0.142
Chylomicron assembly	R-HSA-8963888	7.215672e-01	0.142
Vitamin B1 (thiamin) metabolism	R-HSA-196819	7.215672e-01	0.142
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.215672e-01	0.142
Transport of RCbl within the body	R-HSA-9758890	7.215672e-01	0.142
Prostanoid ligand receptors	R-HSA-391908	7.215672e-01	0.142
Dissolution of Fibrin Clot	R-HSA-75205	7.215672e-01	0.142
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	7.221043e-01	0.141
NOD1/2 Signaling Pathway	R-HSA-168638	7.221043e-01	0.141
Signaling by NOTCH2	R-HSA-1980145	7.221043e-01	0.141
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.221043e-01	0.141
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.242801e-01	0.140
PI-3K cascade:FGFR1	R-HSA-5654689	7.242801e-01	0.140
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.242801e-01	0.140
LDL clearance	R-HSA-8964038	7.242801e-01	0.140
Signaling by KIT in disease	R-HSA-9669938	7.242801e-01	0.140
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.242801e-01	0.140
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.254080e-01	0.139
mRNA Splicing - Minor Pathway	R-HSA-72165	7.254080e-01	0.139
Diseases of DNA repair	R-HSA-9675135	7.254080e-01	0.139
NoRC negatively regulates rRNA expression	R-HSA-427413	7.261608e-01	0.139
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.307703e-01	0.136
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.369422e-01	0.133
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.383634e-01	0.132
tRNA processing	R-HSA-72306	7.404323e-01	0.131
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.419017e-01	0.130
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.419017e-01	0.130
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.419017e-01	0.130
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.423453e-01	0.129
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.423453e-01	0.129
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.423453e-01	0.129
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.423453e-01	0.129
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.423453e-01	0.129
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.423453e-01	0.129
Protein-protein interactions at synapses	R-HSA-6794362	7.434959e-01	0.129
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	7.458799e-01	0.127
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	7.458799e-01	0.127
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.458799e-01	0.127
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.458799e-01	0.127
Integration of provirus	R-HSA-162592	7.458799e-01	0.127
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.458799e-01	0.127
NF-kB is activated and signals survival	R-HSA-209560	7.458799e-01	0.127
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.458799e-01	0.127
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.458799e-01	0.127
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.458799e-01	0.127
Sodium/Calcium exchangers	R-HSA-425561	7.458799e-01	0.127
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.462404e-01	0.127
SARS-CoV-1-host interactions	R-HSA-9692914	7.480922e-01	0.126
NGF-stimulated transcription	R-HSA-9031628	7.508507e-01	0.124
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	7.511454e-01	0.124
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.511454e-01	0.124
Lysosome Vesicle Biogenesis	R-HSA-432720	7.511454e-01	0.124
RET signaling	R-HSA-8853659	7.511454e-01	0.124
Formation of paraxial mesoderm	R-HSA-9793380	7.535498e-01	0.123
MAP kinase activation	R-HSA-450294	7.535498e-01	0.123
Ribosome-associated quality control	R-HSA-9948299	7.536161e-01	0.123
Signaling by NOTCH4	R-HSA-9013694	7.576777e-01	0.121
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.585497e-01	0.120
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.585497e-01	0.120
CD209 (DC-SIGN) signaling	R-HSA-5621575	7.585497e-01	0.120
Plasma lipoprotein assembly	R-HSA-8963898	7.585497e-01	0.120
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	7.585497e-01	0.120
NCAM signaling for neurite out-growth	R-HSA-375165	7.643864e-01	0.117
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	7.647260e-01	0.116
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.675709e-01	0.115
Telomere Maintenance	R-HSA-157579	7.677150e-01	0.115
Cellular response to chemical stress	R-HSA-9711123	7.679521e-01	0.115
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	7.680709e-01	0.115
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	7.680709e-01	0.115
Maple Syrup Urine Disease	R-HSA-9865114	7.680709e-01	0.115
GRB2 events in EGFR signaling	R-HSA-179812	7.680709e-01	0.115
SHC-related events triggered by IGF1R	R-HSA-2428933	7.680709e-01	0.115
Regulation of IFNG signaling	R-HSA-877312	7.680709e-01	0.115
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.680709e-01	0.115
VLDLR internalisation and degradation	R-HSA-8866427	7.680709e-01	0.115
Diseases associated with surfactant metabolism	R-HSA-5687613	7.680709e-01	0.115
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.692728e-01	0.114
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.742597e-01	0.111
Acyl chain remodelling of PS	R-HSA-1482801	7.742597e-01	0.111
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.742597e-01	0.111
MET promotes cell motility	R-HSA-8875878	7.776975e-01	0.109
Elastic fibre formation	R-HSA-1566948	7.776975e-01	0.109
FOXO-mediated transcription	R-HSA-9614085	7.844310e-01	0.105
Meiotic recombination	R-HSA-912446	7.855609e-01	0.105
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.858757e-01	0.105
Chromosome Maintenance	R-HSA-73886	7.858757e-01	0.105
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.883253e-01	0.103
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.883253e-01	0.103
Chylomicron remodeling	R-HSA-8963901	7.883253e-01	0.103
FGFR1c ligand binding and activation	R-HSA-190373	7.883253e-01	0.103
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.883253e-01	0.103
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	7.883253e-01	0.103
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.883253e-01	0.103
Maturation of nucleoprotein	R-HSA-9683610	7.883253e-01	0.103
Interleukin-6 signaling	R-HSA-1059683	7.883253e-01	0.103
Signaling by EGFR in Cancer	R-HSA-1643713	7.890686e-01	0.103
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.890686e-01	0.103
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	7.900746e-01	0.102
Plasma lipoprotein clearance	R-HSA-8964043	7.900746e-01	0.102
Stabilization of p53	R-HSA-69541	7.900746e-01	0.102
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.900746e-01	0.102
ABC-family proteins mediated transport	R-HSA-382556	7.924495e-01	0.101
Integrin cell surface interactions	R-HSA-216083	7.954411e-01	0.099
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.962374e-01	0.099
Hemostasis	R-HSA-109582	7.969875e-01	0.099
Toll-like Receptor Cascades	R-HSA-168898	7.978034e-01	0.098
Extra-nuclear estrogen signaling	R-HSA-9009391	8.002438e-01	0.097
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.018731e-01	0.096
Glycogen metabolism	R-HSA-8982491	8.018731e-01	0.096
Interleukin-2 family signaling	R-HSA-451927	8.018731e-01	0.096
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.030140e-01	0.095
Packaging Of Telomere Ends	R-HSA-171306	8.030140e-01	0.095
Cristae formation	R-HSA-8949613	8.030140e-01	0.095
RNA Polymerase I Promoter Opening	R-HSA-73728	8.030140e-01	0.095
Triglyceride biosynthesis	R-HSA-75109	8.030140e-01	0.095
Signaling by BMP	R-HSA-201451	8.030140e-01	0.095
Immune System	R-HSA-168256	8.042062e-01	0.095
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.068119e-01	0.093
Synthesis of IPs in the nucleus	R-HSA-1855191	8.068119e-01	0.093
Biosynthesis of protectins	R-HSA-9018681	8.068119e-01	0.093
Retrograde neurotrophin signalling	R-HSA-177504	8.068119e-01	0.093
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	8.068119e-01	0.093
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.068119e-01	0.093
HDL assembly	R-HSA-8963896	8.068119e-01	0.093
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.125454e-01	0.090
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.131096e-01	0.090
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.131096e-01	0.090
Hh mutants are degraded by ERAD	R-HSA-5362768	8.131096e-01	0.090
Maturation of spike protein	R-HSA-9694548	8.131096e-01	0.090
Telomere Extension By Telomerase	R-HSA-171319	8.161336e-01	0.088
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.161336e-01	0.088
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.163019e-01	0.088
Signaling by Insulin receptor	R-HSA-74752	8.209841e-01	0.086
C-type lectin receptors (CLRs)	R-HSA-5621481	8.224637e-01	0.085
SHC1 events in EGFR signaling	R-HSA-180336	8.236851e-01	0.084
Telomere C-strand synthesis initiation	R-HSA-174430	8.236851e-01	0.084
Biotin transport and metabolism	R-HSA-196780	8.236851e-01	0.084
p38MAPK events	R-HSA-171007	8.236851e-01	0.084
Lysosphingolipid and LPA receptors	R-HSA-419408	8.236851e-01	0.084
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.236851e-01	0.084
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.238013e-01	0.084
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.238013e-01	0.084
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.242809e-01	0.084
Signaling by Erythropoietin	R-HSA-9006335	8.284653e-01	0.082
DNA methylation	R-HSA-5334118	8.284653e-01	0.082
mRNA Capping	R-HSA-72086	8.284653e-01	0.082
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.284653e-01	0.082
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.284653e-01	0.082
Cytosolic tRNA aminoacylation	R-HSA-379716	8.339658e-01	0.079
Cleavage of the damaged pyrimidine	R-HSA-110329	8.339658e-01	0.079
Depyrimidination	R-HSA-73928	8.339658e-01	0.079
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.347135e-01	0.078
Signaling by FGFR1	R-HSA-5654736	8.347135e-01	0.078
Intrinsic Pathway for Apoptosis	R-HSA-109606	8.347135e-01	0.078
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.354490e-01	0.078
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	8.383679e-01	0.077
Interleukin-17 signaling	R-HSA-448424	8.383679e-01	0.077
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.384944e-01	0.076
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.390854e-01	0.076
Defective GALNT3 causes HFTC	R-HSA-5083625	8.390854e-01	0.076
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.390854e-01	0.076
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.390854e-01	0.076
Activation of SMO	R-HSA-5635838	8.390854e-01	0.076
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.390854e-01	0.076
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.390854e-01	0.076
Differentiation of T cells	R-HSA-9945266	8.390854e-01	0.076
Regulation of NF-kappa B signaling	R-HSA-9758274	8.390854e-01	0.076
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.390854e-01	0.076
Attachment and Entry	R-HSA-9678110	8.390854e-01	0.076
Disorders of transmembrane transporters	R-HSA-5619115	8.405673e-01	0.075
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.436214e-01	0.074
Hedgehog 'on' state	R-HSA-5632684	8.461162e-01	0.073
Synthesis of DNA	R-HSA-69239	8.487229e-01	0.071
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	8.489700e-01	0.071
Downstream signal transduction	R-HSA-186763	8.509144e-01	0.070
Ion channel transport	R-HSA-983712	8.512888e-01	0.070
Dual incision in TC-NER	R-HSA-6782135	8.515569e-01	0.070
DAP12 interactions	R-HSA-2172127	8.527861e-01	0.069
Amine ligand-binding receptors	R-HSA-375280	8.527861e-01	0.069
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	8.527861e-01	0.069
G beta:gamma signalling through CDC42	R-HSA-8964616	8.531414e-01	0.069
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.531414e-01	0.069
Phase 2 - plateau phase	R-HSA-5576893	8.531414e-01	0.069
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.531414e-01	0.069
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.531414e-01	0.069
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	8.531414e-01	0.069
Coenzyme A biosynthesis	R-HSA-196783	8.531414e-01	0.069
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.531414e-01	0.069
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	8.535547e-01	0.069
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.571581e-01	0.067
Peroxisomal protein import	R-HSA-9033241	8.594184e-01	0.066
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.611050e-01	0.065
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.611050e-01	0.065
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	8.614783e-01	0.065
Nucleosome assembly	R-HSA-774815	8.614783e-01	0.065
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.614783e-01	0.065
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.614783e-01	0.065
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.614783e-01	0.065
Somitogenesis	R-HSA-9824272	8.614783e-01	0.065
XBP1(S) activates chaperone genes	R-HSA-381038	8.636716e-01	0.064
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.659704e-01	0.062
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.659704e-01	0.062
Glycogen storage diseases	R-HSA-3229121	8.659704e-01	0.062
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	8.659704e-01	0.062
tRNA Aminoacylation	R-HSA-379724	8.669217e-01	0.062
Signaling by FGFR	R-HSA-190236	8.675564e-01	0.062
Condensation of Prophase Chromosomes	R-HSA-2299718	8.697165e-01	0.061
Chaperonin-mediated protein folding	R-HSA-390466	8.699371e-01	0.061
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.706538e-01	0.060
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.731326e-01	0.059
Cellular response to starvation	R-HSA-9711097	8.776241e-01	0.057
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.776241e-01	0.057
G beta:gamma signalling through PLC beta	R-HSA-418217	8.776794e-01	0.057
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	8.776794e-01	0.057
Presynaptic function of Kainate receptors	R-HSA-500657	8.776794e-01	0.057
Platelet sensitization by LDL	R-HSA-432142	8.776794e-01	0.057
Tie2 Signaling	R-HSA-210993	8.776794e-01	0.057
Effects of PIP2 hydrolysis	R-HSA-114508	8.795951e-01	0.056
Vpu mediated degradation of CD4	R-HSA-180534	8.795951e-01	0.056
Miscellaneous transport and binding events	R-HSA-5223345	8.795951e-01	0.056
Signaling by PDGF	R-HSA-186797	8.808999e-01	0.055
Formation of the cornified envelope	R-HSA-6809371	8.814197e-01	0.055
Pre-NOTCH Expression and Processing	R-HSA-1912422	8.823686e-01	0.054
Interleukin-1 signaling	R-HSA-9020702	8.842197e-01	0.053
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.849030e-01	0.053
Neurotransmitter release cycle	R-HSA-112310	8.873069e-01	0.052
G1/S DNA Damage Checkpoints	R-HSA-69615	8.873981e-01	0.052
Dual Incision in GG-NER	R-HSA-5696400	8.879621e-01	0.052
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.879621e-01	0.052
Hyaluronan metabolism	R-HSA-2142845	8.879621e-01	0.052
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.879621e-01	0.052
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.879621e-01	0.052
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.883661e-01	0.051
E2F mediated regulation of DNA replication	R-HSA-113510	8.883661e-01	0.051
The NLRP3 inflammasome	R-HSA-844456	8.883661e-01	0.051
HDL remodeling	R-HSA-8964058	8.883661e-01	0.051
Maturation of nucleoprotein	R-HSA-9694631	8.883661e-01	0.051
p53-Dependent G1 DNA Damage Response	R-HSA-69563	8.918873e-01	0.050
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	8.918873e-01	0.050
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	8.935843e-01	0.049
Downstream signaling of activated FGFR1	R-HSA-5654687	8.957868e-01	0.048
Transferrin endocytosis and recycling	R-HSA-917977	8.957868e-01	0.048
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.957868e-01	0.048
Neutrophil degranulation	R-HSA-6798695	8.972730e-01	0.047
IRE1alpha activates chaperones	R-HSA-381070	8.977608e-01	0.047
Glycogen synthesis	R-HSA-3322077	8.981197e-01	0.047
Pregnenolone biosynthesis	R-HSA-196108	8.981197e-01	0.047
Protein hydroxylation	R-HSA-9629569	8.981197e-01	0.047
Eicosanoid ligand-binding receptors	R-HSA-391903	8.981197e-01	0.047
G2/M Checkpoints	R-HSA-69481	8.995458e-01	0.046
Unfolded Protein Response (UPR)	R-HSA-381119	9.026247e-01	0.044
Protein folding	R-HSA-391251	9.026688e-01	0.044
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.026688e-01	0.044
Signaling by FGFR2	R-HSA-5654738	9.028786e-01	0.044
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.028786e-01	0.044
G1/S-Specific Transcription	R-HSA-69205	9.031002e-01	0.044
Glycosphingolipid transport	R-HSA-9845576	9.031002e-01	0.044
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.031002e-01	0.044
FGFR2 mutant receptor activation	R-HSA-1839126	9.031002e-01	0.044
Transport to the Golgi and subsequent modification	R-HSA-948021	9.032820e-01	0.044
RSV-host interactions	R-HSA-9833110	9.036754e-01	0.044
Signaling by NTRK1 (TRKA)	R-HSA-187037	9.036968e-01	0.044
Hedgehog ligand biogenesis	R-HSA-5358346	9.047253e-01	0.043
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.065079e-01	0.043
Leishmania phagocytosis	R-HSA-9664417	9.065079e-01	0.043
Parasite infection	R-HSA-9664407	9.065079e-01	0.043
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.070217e-01	0.042
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.070217e-01	0.042
ERK/MAPK targets	R-HSA-198753	9.070217e-01	0.042
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.070217e-01	0.042
Abacavir metabolism	R-HSA-2161541	9.070217e-01	0.042
Zygotic genome activation (ZGA)	R-HSA-9819196	9.070217e-01	0.042
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.070217e-01	0.042
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.070217e-01	0.042
Signalling to RAS	R-HSA-167044	9.070217e-01	0.042
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.073728e-01	0.042
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.099318e-01	0.041
TRAF6 mediated IRF7 activation	R-HSA-933541	9.099318e-01	0.041
Degradation of AXIN	R-HSA-4641257	9.099318e-01	0.041
Cleavage of the damaged purine	R-HSA-110331	9.099318e-01	0.041
NCAM1 interactions	R-HSA-419037	9.099318e-01	0.041
Collagen chain trimerization	R-HSA-8948216	9.099318e-01	0.041
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.102605e-01	0.041
Kidney development	R-HSA-9830369	9.103860e-01	0.041
RNA Polymerase I Promoter Escape	R-HSA-73772	9.106130e-01	0.041
Neurexins and neuroligins	R-HSA-6794361	9.106130e-01	0.041
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.151463e-01	0.039
Ribavirin ADME	R-HSA-9755088	9.151463e-01	0.039
Mitochondrial calcium ion transport	R-HSA-8949215	9.151463e-01	0.039
Attachment and Entry	R-HSA-9694614	9.151463e-01	0.039
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.161938e-01	0.038
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.161938e-01	0.038
Depurination	R-HSA-73927	9.163100e-01	0.038
PPARA activates gene expression	R-HSA-1989781	9.164039e-01	0.038
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.173603e-01	0.037
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.173603e-01	0.037
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.214071e-01	0.036
Neuronal System	R-HSA-112316	9.214264e-01	0.036
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.222617e-01	0.035
Pentose phosphate pathway	R-HSA-71336	9.222617e-01	0.035
Biosynthesis of D-series resolvins	R-HSA-9018676	9.225614e-01	0.035
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.225614e-01	0.035
Cellular hexose transport	R-HSA-189200	9.225614e-01	0.035
G alpha (z) signalling events	R-HSA-418597	9.263448e-01	0.033
Paracetamol ADME	R-HSA-9753281	9.263448e-01	0.033
Nuclear signaling by ERBB4	R-HSA-1251985	9.278129e-01	0.033
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.278129e-01	0.033
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.278129e-01	0.033
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.279614e-01	0.032
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.279614e-01	0.032
Termination of O-glycan biosynthesis	R-HSA-977068	9.293290e-01	0.032
Free fatty acids regulate insulin secretion	R-HSA-400451	9.293290e-01	0.032
Interleukin receptor SHC signaling	R-HSA-912526	9.293290e-01	0.032
Mitochondrial mRNA modification	R-HSA-9937008	9.293290e-01	0.032
Carnitine shuttle	R-HSA-200425	9.293290e-01	0.032
Formation of the ureteric bud	R-HSA-9830674	9.293290e-01	0.032
Growth hormone receptor signaling	R-HSA-982772	9.293290e-01	0.032
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.312228e-01	0.031
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.316611e-01	0.031
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.316611e-01	0.031
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.316611e-01	0.031
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.329880e-01	0.030
Resolution of Abasic Sites (AP sites)	R-HSA-73933	9.329880e-01	0.030
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.329880e-01	0.030
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.355054e-01	0.029
TRAF6 mediated NF-kB activation	R-HSA-933542	9.355054e-01	0.029
Mitochondrial RNA degradation	R-HSA-9836573	9.355054e-01	0.029
Complex III assembly	R-HSA-9865881	9.355054e-01	0.029
TNFs bind their physiological receptors	R-HSA-5669034	9.355054e-01	0.029
Interleukin-6 family signaling	R-HSA-6783589	9.355054e-01	0.029
Signaling by NTRKs	R-HSA-166520	9.359434e-01	0.029
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.374821e-01	0.028
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.378103e-01	0.028
Intra-Golgi traffic	R-HSA-6811438	9.378103e-01	0.028
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.378103e-01	0.028
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.378103e-01	0.028
Signaling by ERBB4	R-HSA-1236394	9.407386e-01	0.027
Polymerase switching on the C-strand of the telomere	R-HSA-174411	9.411424e-01	0.026
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.411424e-01	0.026
Hyaluronan degradation	R-HSA-2160916	9.411424e-01	0.026
Formation of the nephric duct	R-HSA-9830364	9.411424e-01	0.026
Laminin interactions	R-HSA-3000157	9.411424e-01	0.026
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.411424e-01	0.026
Extension of Telomeres	R-HSA-180786	9.433750e-01	0.025
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.442130e-01	0.025
Iron uptake and transport	R-HSA-917937	9.442130e-01	0.025
Phospholipid metabolism	R-HSA-1483257	9.458739e-01	0.024
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.462871e-01	0.024
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.462871e-01	0.024
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.462871e-01	0.024
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.462871e-01	0.024
TRP channels	R-HSA-3295583	9.462871e-01	0.024
Abacavir ADME	R-HSA-2161522	9.462871e-01	0.024
Signaling by FGFR4	R-HSA-5654743	9.464840e-01	0.024
DNA Replication	R-HSA-69306	9.485358e-01	0.023
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.501377e-01	0.022
Proteasome assembly	R-HSA-9907900	9.503761e-01	0.022
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.503761e-01	0.022
Surfactant metabolism	R-HSA-5683826	9.503761e-01	0.022
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.504465e-01	0.022
Collagen degradation	R-HSA-1442490	9.504465e-01	0.022
Translation of Structural Proteins	R-HSA-9694635	9.506092e-01	0.022
RNA Polymerase I Transcription Termination	R-HSA-73863	9.509823e-01	0.022
Synthesis of PE	R-HSA-1483213	9.509823e-01	0.022
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.509823e-01	0.022
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.509823e-01	0.022
Maturation of hRSV A proteins	R-HSA-9828806	9.509823e-01	0.022
Mitochondrial protein import	R-HSA-1268020	9.536650e-01	0.021
Signaling by FGFR3	R-HSA-5654741	9.539970e-01	0.020
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.539970e-01	0.020
Insulin receptor recycling	R-HSA-77387	9.552673e-01	0.020
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.552673e-01	0.020
Inflammasomes	R-HSA-622312	9.552673e-01	0.020
Pyroptosis	R-HSA-5620971	9.552673e-01	0.020
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.573643e-01	0.019
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.591780e-01	0.018
DARPP-32 events	R-HSA-180024	9.591780e-01	0.018
Collagen formation	R-HSA-1474290	9.600336e-01	0.018
Interferon gamma signaling	R-HSA-877300	9.607331e-01	0.017
Amyloid fiber formation	R-HSA-977225	9.614249e-01	0.017
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.619564e-01	0.017
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.619564e-01	0.017
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.619564e-01	0.017
Stimuli-sensing channels	R-HSA-2672351	9.619564e-01	0.017
Mitotic G1 phase and G1/S transition	R-HSA-453279	9.626870e-01	0.017
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.627470e-01	0.016
Neurotransmitter clearance	R-HSA-112311	9.627470e-01	0.016
Plasma lipoprotein remodeling	R-HSA-8963899	9.634040e-01	0.016
Metal ion SLC transporters	R-HSA-425410	9.634040e-01	0.016
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.639894e-01	0.016
SARS-CoV-1 Infection	R-HSA-9678108	9.657827e-01	0.015
Chemokine receptors bind chemokines	R-HSA-380108	9.661068e-01	0.015
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.663309e-01	0.015
Azathioprine ADME	R-HSA-9748787	9.686169e-01	0.014
Signaling by FGFR2 in disease	R-HSA-5655253	9.686169e-01	0.014
The phototransduction cascade	R-HSA-2514856	9.709474e-01	0.013
Activation of ATR in response to replication stress	R-HSA-176187	9.716896e-01	0.012
Recycling of bile acids and salts	R-HSA-159418	9.716896e-01	0.012
Synthesis of bile acids and bile salts	R-HSA-192105	9.719048e-01	0.012
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.721020e-01	0.012
Orc1 removal from chromatin	R-HSA-68949	9.731105e-01	0.012
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.731105e-01	0.012
Protein localization	R-HSA-9609507	9.734427e-01	0.012
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.741653e-01	0.011
Acyl chain remodelling of PC	R-HSA-1482788	9.741653e-01	0.011
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.741653e-01	0.011
Heme degradation	R-HSA-189483	9.741653e-01	0.011
ECM proteoglycans	R-HSA-3000178	9.749969e-01	0.011
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.764247e-01	0.010
NPAS4 regulates expression of target genes	R-HSA-9768919	9.764247e-01	0.010
Interferon alpha/beta signaling	R-HSA-909733	9.770049e-01	0.010
Cap-dependent Translation Initiation	R-HSA-72737	9.782826e-01	0.010
Eukaryotic Translation Initiation	R-HSA-72613	9.782826e-01	0.010
Acyl chain remodelling of PE	R-HSA-1482839	9.784865e-01	0.009
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.784865e-01	0.009
Base Excision Repair	R-HSA-73884	9.795989e-01	0.009
FCERI mediated NF-kB activation	R-HSA-2871837	9.801301e-01	0.009
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.808843e-01	0.008
Dectin-2 family	R-HSA-5621480	9.817909e-01	0.008
Synthesis of PA	R-HSA-1483166	9.817909e-01	0.008
Voltage gated Potassium channels	R-HSA-1296072	9.820854e-01	0.008
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.820854e-01	0.008
SLC-mediated transport of organic cations	R-HSA-549127	9.820854e-01	0.008
Platelet homeostasis	R-HSA-418346	9.826863e-01	0.008
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.832290e-01	0.007
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.836525e-01	0.007
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.836525e-01	0.007
Amino acid transport across the plasma membrane	R-HSA-352230	9.844399e-01	0.007
Triglyceride metabolism	R-HSA-8979227	9.844399e-01	0.007
ABC transporter disorders	R-HSA-5619084	9.847376e-01	0.007
Cholesterol biosynthesis	R-HSA-191273	9.847376e-01	0.007
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.850826e-01	0.007
RAS processing	R-HSA-9648002	9.850826e-01	0.007
Metabolism of polyamines	R-HSA-351202	9.856199e-01	0.006
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.863877e-01	0.006
Diseases of Immune System	R-HSA-5260271	9.863877e-01	0.006
Tryptophan catabolism	R-HSA-71240	9.863877e-01	0.006
Bile acid and bile salt metabolism	R-HSA-194068	9.864840e-01	0.006
Formation of a pool of free 40S subunits	R-HSA-72689	9.871255e-01	0.006
G1/S Transition	R-HSA-69206	9.878901e-01	0.005
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.886607e-01	0.005
Translation of Structural Proteins	R-HSA-9683701	9.886654e-01	0.005
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.893409e-01	0.005
Regulation of insulin secretion	R-HSA-422356	9.894650e-01	0.005
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.896572e-01	0.005
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.896572e-01	0.005
Defensins	R-HSA-1461973	9.905623e-01	0.004
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.910710e-01	0.004
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.913882e-01	0.004
SLC-mediated transport of amino acids	R-HSA-9958863	9.917570e-01	0.004
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.917570e-01	0.004
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.923915e-01	0.003
Regulation of pyruvate metabolism	R-HSA-9861718	9.928296e-01	0.003
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.928296e-01	0.003
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.928296e-01	0.003
Peptide chain elongation	R-HSA-156902	9.931150e-01	0.003
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.934572e-01	0.003
Synthesis of PC	R-HSA-1483191	9.934572e-01	0.003
ER-Phagosome pathway	R-HSA-1236974	9.936027e-01	0.003
Retinoid metabolism and transport	R-HSA-975634	9.940214e-01	0.003
Gluconeogenesis	R-HSA-70263	9.940300e-01	0.003
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.944845e-01	0.002
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.945526e-01	0.002
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.948732e-01	0.002
Antigen processing-Cross presentation	R-HSA-1236975	9.950255e-01	0.002
Eukaryotic Translation Elongation	R-HSA-156842	9.952395e-01	0.002
Branched-chain amino acid catabolism	R-HSA-70895	9.954646e-01	0.002
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.955329e-01	0.002
Post-translational protein modification	R-HSA-597592	9.955542e-01	0.002
Uptake and actions of bacterial toxins	R-HSA-5339562	9.958617e-01	0.002
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.960484e-01	0.002
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.962337e-01	0.002
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.962337e-01	0.002
Eukaryotic Translation Termination	R-HSA-72764	9.964665e-01	0.002
Interleukin-10 signaling	R-HSA-6783783	9.966086e-01	0.001
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.971317e-01	0.001
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.973447e-01	0.001
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.973498e-01	0.001
Role of phospholipids in phagocytosis	R-HSA-2029485	9.973498e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.974971e-01	0.001
Extracellular matrix organization	R-HSA-1474244	9.975043e-01	0.001
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.976121e-01	0.001
Peptide hormone metabolism	R-HSA-2980736	9.976999e-01	0.001
Selenocysteine synthesis	R-HSA-2408557	9.977503e-01	0.001
RAB geranylgeranylation	R-HSA-8873719	9.980121e-01	0.001
Viral mRNA Translation	R-HSA-192823	9.980667e-01	0.001
Endogenous sterols	R-HSA-211976	9.981863e-01	0.001
Integration of energy metabolism	R-HSA-163685	9.982141e-01	0.001
Parasitic Infection Pathways	R-HSA-9824443	9.984047e-01	0.001
Leishmania infection	R-HSA-9658195	9.984047e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.984901e-01	0.001
Cell surface interactions at the vascular wall	R-HSA-202733	9.985924e-01	0.001
Keratinization	R-HSA-6805567	9.986771e-01	0.001
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.986796e-01	0.001
Nicotinate metabolism	R-HSA-196807	9.989538e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.989538e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.990288e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.990454e-01	0.000
Regulated Necrosis	R-HSA-5218859	9.990454e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.991009e-01	0.000
FCGR activation	R-HSA-2029481	9.991624e-01	0.000
COPII-mediated vesicle transport	R-HSA-204005	9.992054e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.992054e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.992292e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.992751e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.992751e-01	0.000
Purine catabolism	R-HSA-74259	9.993386e-01	0.000
Infectious disease	R-HSA-5663205	9.993613e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.993966e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.993995e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.994495e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.994918e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.995027e-01	0.000
Disease	R-HSA-1643685	9.997002e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.997006e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.997104e-01	0.000
rRNA processing	R-HSA-72312	9.997269e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.997614e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.997642e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.997801e-01	0.000
Visual phototransduction	R-HSA-2187338	9.998090e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.998331e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.998438e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.998477e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.998844e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.998882e-01	0.000
Innate Immune System	R-HSA-168249	9.999037e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999119e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999334e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999377e-01	0.000
Potassium Channels	R-HSA-1296071	9.999446e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999459e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999531e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999558e-01	0.000
Translation	R-HSA-72766	9.999643e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999689e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999758e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999766e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999913e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999928e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999954e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999961e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999961e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999965e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999965e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999971e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999981e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999982e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999986e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999990e-01	0.000
Transport of small molecules	R-HSA-382551	9.999992e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999993e-01	0.000
Drug ADME	R-HSA-9748784	9.999994e-01	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.999996e-01	0.000
Complement cascade	R-HSA-166658	9.999997e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999999e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
HSF1-dependent transactivation	R-HSA-3371571	6.661338e-15	14.176
Cell Cycle	R-HSA-1640170	8.215650e-15	14.085
Attenuation phase	R-HSA-3371568	3.419487e-14	13.466
Cellular response to heat stress	R-HSA-3371556	5.273559e-14	13.278
Metabolism of RNA	R-HSA-8953854	5.218048e-14	13.282
Cell Cycle, Mitotic	R-HSA-69278	4.371947e-12	11.359
HSF1 activation	R-HSA-3371511	8.455792e-12	11.073
M Phase	R-HSA-68886	8.520185e-12	11.070
Cell-Cell communication	R-HSA-1500931	2.924028e-11	10.534
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.551459e-11	10.450
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.521563e-10	9.598
Cell junction organization	R-HSA-446728	6.810051e-10	9.167
Cellular responses to stimuli	R-HSA-8953897	8.166448e-10	9.088
G2/M Checkpoints	R-HSA-69481	1.715501e-09	8.766
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.925628e-09	8.715
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.925628e-09	8.715
Adherens junctions interactions	R-HSA-418990	5.170783e-09	8.286
Apoptotic cleavage of cellular proteins	R-HSA-111465	6.924704e-09	8.160
Cellular responses to stress	R-HSA-2262752	7.735832e-09	8.111
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.062431e-08	7.974
mRNA Splicing - Major Pathway	R-HSA-72163	1.724226e-08	7.763
Apoptotic execution phase	R-HSA-75153	1.757607e-08	7.755
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.285091e-08	7.641
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.437333e-08	7.613
Cell Cycle Checkpoints	R-HSA-69620	2.545679e-08	7.594
Cell-cell junction organization	R-HSA-421270	2.564240e-08	7.591
Meiotic synapsis	R-HSA-1221632	3.363522e-08	7.473
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.363522e-08	7.473
mRNA Splicing	R-HSA-72172	3.106260e-08	7.508
Chromatin organization	R-HSA-4839726	4.732540e-08	7.325
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	5.718157e-08	7.243
DNA Double Strand Break Response	R-HSA-5693606	8.873660e-08	7.052
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.060082e-07	6.975
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.423512e-07	6.847
Protein ubiquitination	R-HSA-8852135	1.609561e-07	6.793
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.821638e-07	6.740
Chromatin modifying enzymes	R-HSA-3247509	2.324996e-07	6.634
Epigenetic regulation of gene expression	R-HSA-212165	2.531786e-07	6.597
Apoptosis	R-HSA-109581	3.156499e-07	6.501
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.128694e-07	6.290
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	7.080267e-07	6.150
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.044081e-07	6.095
NoRC negatively regulates rRNA expression	R-HSA-427413	8.029344e-07	6.095
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.317186e-07	6.080
TCF dependent signaling in response to WNT	R-HSA-201681	9.439151e-07	6.025
RNA Polymerase I Transcription	R-HSA-73864	1.042891e-06	5.982
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.431766e-06	5.844
G2/M DNA damage checkpoint	R-HSA-69473	1.513612e-06	5.820
Estrogen-dependent gene expression	R-HSA-9018519	2.036973e-06	5.691
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.268766e-06	5.644
Transcriptional regulation by RUNX1	R-HSA-8878171	2.424845e-06	5.615
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.569688e-06	5.590
HDACs deacetylate histones	R-HSA-3214815	3.393102e-06	5.469
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.354940e-06	5.474
DNA Double-Strand Break Repair	R-HSA-5693532	3.673058e-06	5.435
Mitotic Anaphase	R-HSA-68882	4.001323e-06	5.398
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.020059e-06	5.396
Mitotic Metaphase and Anaphase	R-HSA-2555396	4.451240e-06	5.352
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.897470e-06	5.310
Regulation of endogenous retroelements	R-HSA-9842860	4.952230e-06	5.305
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.682608e-06	5.245
Cohesin Loading onto Chromatin	R-HSA-2470946	5.965291e-06	5.224
Programmed Cell Death	R-HSA-5357801	5.931468e-06	5.227
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.999232e-06	5.222
Mitotic Prophase	R-HSA-68875	6.127043e-06	5.213
Mitotic Prometaphase	R-HSA-68877	7.061295e-06	5.151
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.046126e-05	4.980
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.006288e-05	4.997
Separation of Sister Chromatids	R-HSA-2467813	1.406936e-05	4.852
Regulation of CDH1 Function	R-HSA-9764561	1.817113e-05	4.741
Processing of DNA double-strand break ends	R-HSA-5693607	1.760526e-05	4.754
Assembly of the pre-replicative complex	R-HSA-68867	2.166530e-05	4.664
Interleukin-12 signaling	R-HSA-9020591	2.178219e-05	4.662
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.206819e-05	4.494
ESR-mediated signaling	R-HSA-8939211	3.188593e-05	4.496
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.371145e-05	4.472
Meiosis	R-HSA-1500620	3.425046e-05	4.465
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.031117e-05	4.395
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.044405e-05	4.393
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	4.435510e-05	4.353
DNA Replication Pre-Initiation	R-HSA-69002	4.308557e-05	4.366
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.837941e-05	4.315
Interleukin-12 family signaling	R-HSA-447115	5.486691e-05	4.261
RNA Polymerase I Promoter Escape	R-HSA-73772	7.109997e-05	4.148
Regulation of TP53 Degradation	R-HSA-6804757	7.298466e-05	4.137
Homology Directed Repair	R-HSA-5693538	7.364615e-05	4.133
G2/M Transition	R-HSA-69275	7.442453e-05	4.128
Deubiquitination	R-HSA-5688426	7.752858e-05	4.111
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	8.245575e-05	4.084
Signaling by ALK in cancer	R-HSA-9700206	8.245575e-05	4.084
Mitotic G2-G2/M phases	R-HSA-453274	9.036231e-05	4.044
Signaling by WNT	R-HSA-195721	9.865359e-05	4.006
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.019466e-04	3.992
DNA Repair	R-HSA-73894	1.364854e-04	3.865
DNA methylation	R-HSA-5334118	1.459755e-04	3.836
rRNA processing	R-HSA-72312	1.581217e-04	3.801
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.731172e-04	3.762
Diseases of programmed cell death	R-HSA-9645723	1.685000e-04	3.773
Nucleosome assembly	R-HSA-774815	1.866146e-04	3.729
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.866146e-04	3.729
Ub-specific processing proteases	R-HSA-5689880	1.904796e-04	3.720
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.906769e-04	3.720
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.152043e-04	3.667
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.156820e-04	3.666
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.584276e-04	3.588
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.584276e-04	3.588
PRC2 methylates histones and DNA	R-HSA-212300	2.636573e-04	3.579
Translation initiation complex formation	R-HSA-72649	3.192758e-04	3.496
HIV Life Cycle	R-HSA-162587	3.321984e-04	3.479
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.441427e-04	3.463
HATs acetylate histones	R-HSA-3214847	3.761579e-04	3.425
Chaperone Mediated Autophagy	R-HSA-9613829	3.764483e-04	3.424
Regulation of TP53 Activity	R-HSA-5633007	4.409877e-04	3.356
Ribosomal scanning and start codon recognition	R-HSA-72702	4.480257e-04	3.349
Transcriptional Regulation by TP53	R-HSA-3700989	4.732529e-04	3.325
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	4.893820e-04	3.310
Degradation of beta-catenin by the destruction complex	R-HSA-195253	5.176244e-04	3.286
Inhibition of DNA recombination at telomere	R-HSA-9670095	5.998356e-04	3.222
MAPK6/MAPK4 signaling	R-HSA-5687128	6.243972e-04	3.205
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	6.598607e-04	3.181
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	6.608706e-04	3.180
Cap-dependent Translation Initiation	R-HSA-72737	7.086264e-04	3.150
Eukaryotic Translation Initiation	R-HSA-72613	7.086264e-04	3.150
Condensation of Prophase Chromosomes	R-HSA-2299718	7.023300e-04	3.153
Downregulation of ERBB2 signaling	R-HSA-8863795	6.976716e-04	3.156
HIV Infection	R-HSA-162906	7.088399e-04	3.149
PKMTs methylate histone lysines	R-HSA-3214841	7.255379e-04	3.139
Reproduction	R-HSA-1474165	7.888110e-04	3.103
EPH-Ephrin signaling	R-HSA-2682334	7.980214e-04	3.098
SWI/SNF chromatin remodelers	R-HSA-9932451	8.025931e-04	3.096
ATP-dependent chromatin remodelers	R-HSA-9932444	8.025931e-04	3.096
p75 NTR receptor-mediated signalling	R-HSA-193704	8.786729e-04	3.056
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.874996e-04	3.052
Co-inhibition by PD-1	R-HSA-389948	9.876098e-04	3.005
Regulation of T cell activation by CD28 family	R-HSA-388841	9.685678e-04	3.014
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.016658e-03	2.993
DNA Replication	R-HSA-69306	9.505720e-04	3.022
Gene expression (Transcription)	R-HSA-74160	9.379211e-04	3.028
PTEN Regulation	R-HSA-6807070	9.910678e-04	3.004
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.017594e-03	2.992
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.029039e-03	2.988
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.038424e-03	2.984
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.044090e-03	2.981
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.132449e-03	2.946
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.132449e-03	2.946
Packaging Of Telomere Ends	R-HSA-171306	1.273537e-03	2.895
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.179626e-03	2.928
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.230915e-03	2.910
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.184061e-03	2.927
S Phase	R-HSA-69242	1.216686e-03	2.915
Axon guidance	R-HSA-422475	1.159322e-03	2.936
RNA Polymerase I Promoter Opening	R-HSA-73728	1.273537e-03	2.895
Defective pyroptosis	R-HSA-9710421	1.242740e-03	2.906
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.314376e-03	2.881
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.314376e-03	2.881
Membrane Trafficking	R-HSA-199991	1.336050e-03	2.874
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.380855e-03	2.860
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.473738e-03	2.832
Stabilization of p53	R-HSA-69541	1.555080e-03	2.808
Transcriptional Regulation by E2F6	R-HSA-8953750	1.555080e-03	2.808
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.599414e-03	2.796
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.701079e-03	2.769
Aggrephagy	R-HSA-9646399	1.853226e-03	2.732
Formation of RNA Pol II elongation complex	R-HSA-112382	1.858702e-03	2.731
AURKA Activation by TPX2	R-HSA-8854518	1.967455e-03	2.706
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.968571e-03	2.706
Nervous system development	R-HSA-9675108	1.797780e-03	2.745
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.968571e-03	2.706
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.933074e-03	2.714
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.155120e-03	2.667
Smooth Muscle Contraction	R-HSA-445355	2.155120e-03	2.667
Regulation of PTEN gene transcription	R-HSA-8943724	2.220553e-03	2.654
p75NTR signals via NF-kB	R-HSA-193639	2.290161e-03	2.640
Cell-extracellular matrix interactions	R-HSA-446353	2.290161e-03	2.640
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.332988e-03	2.632
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	2.332988e-03	2.632
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.459608e-03	2.609
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.535138e-03	2.596
Regulation of PTEN localization	R-HSA-8948747	2.671416e-03	2.573
Oxidative Stress Induced Senescence	R-HSA-2559580	2.682561e-03	2.571
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.719431e-03	2.566
Late Phase of HIV Life Cycle	R-HSA-162599	2.799013e-03	2.553
UCH proteinases	R-HSA-5689603	2.836753e-03	2.547
Degradation of DVL	R-HSA-4641258	3.286853e-03	2.483
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.286853e-03	2.483
NF-kB is activated and signals survival	R-HSA-209560	3.111989e-03	2.507
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.202572e-03	2.495
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.301387e-03	2.481
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.301387e-03	2.481
Oncogenic MAPK signaling	R-HSA-6802957	3.444622e-03	2.463
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.474024e-03	2.459
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.550406e-03	2.450
Signaling by VEGF	R-HSA-194138	3.836853e-03	2.416
G1/S Transition	R-HSA-69206	3.836853e-03	2.416
Disorders of Developmental Biology	R-HSA-9675151	3.943296e-03	2.404
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.990423e-03	2.399
Formation of annular gap junctions	R-HSA-196025	3.990423e-03	2.399
EPHB-mediated forward signaling	R-HSA-3928662	4.127845e-03	2.384
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.127845e-03	2.384
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.138942e-03	2.383
Transcriptional regulation by small RNAs	R-HSA-5578749	4.138942e-03	2.383
Regulation of MECP2 expression and activity	R-HSA-9022692	4.153189e-03	2.382
Repression of WNT target genes	R-HSA-4641265	4.243552e-03	2.372
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.243552e-03	2.372
p75NTR recruits signalling complexes	R-HSA-209543	4.243552e-03	2.372
FLT3 signaling by CBL mutants	R-HSA-9706377	4.443113e-03	2.352
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	4.320186e-03	2.364
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.872039e-03	2.312
Orc1 removal from chromatin	R-HSA-68949	4.872039e-03	2.312
mRNA 3'-end processing	R-HSA-72187	4.872039e-03	2.312
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.643321e-03	2.333
Cellular Senescence	R-HSA-2559583	4.578900e-03	2.339
Chromosome Maintenance	R-HSA-73886	4.914644e-03	2.309
Amyloid fiber formation	R-HSA-977225	4.977985e-03	2.303
Signaling by NOTCH	R-HSA-157118	5.166146e-03	2.287
RNA Polymerase II Pre-transcription Events	R-HSA-674695	5.196747e-03	2.284
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	5.246512e-03	2.280
Signaling downstream of RAS mutants	R-HSA-9649948	5.508055e-03	2.259
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.508055e-03	2.259
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.508055e-03	2.259
Signaling by RAS mutants	R-HSA-6802949	5.508055e-03	2.259
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.479858e-03	2.188
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.479858e-03	2.188
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.479858e-03	2.188
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.479858e-03	2.188
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.479858e-03	2.188
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.479858e-03	2.188
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	6.479858e-03	2.188
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.479858e-03	2.188
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.479858e-03	2.188
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.479858e-03	2.188
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.479858e-03	2.188
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.479858e-03	2.188
Gap junction degradation	R-HSA-190873	5.719545e-03	2.243
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.653176e-03	2.248
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.248091e-03	2.204
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.373648e-03	2.196
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	6.173108e-03	2.209
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	6.173108e-03	2.209
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.173108e-03	2.209
Hh mutants are degraded by ERAD	R-HSA-5362768	6.173108e-03	2.209
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	5.823306e-03	2.235
Host Interactions of HIV factors	R-HSA-162909	6.310449e-03	2.200
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.834105e-03	2.165
Signaling by ROBO receptors	R-HSA-376176	6.886799e-03	2.162
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	7.050882e-03	2.152
Maturation of protein E	R-HSA-9694493	7.050882e-03	2.152
Maturation of protein E	R-HSA-9683683	7.050882e-03	2.152
Signaling by RAF1 mutants	R-HSA-9656223	7.138531e-03	2.146
Degradation of GLI1 by the proteasome	R-HSA-5610780	7.138531e-03	2.146
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.138531e-03	2.146
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.138531e-03	2.146
Signaling by TGF-beta Receptor Complex	R-HSA-170834	7.233007e-03	2.141
Transcriptional regulation by RUNX3	R-HSA-8878159	7.233007e-03	2.141
Activation of HOX genes during differentiation	R-HSA-5619507	7.350906e-03	2.134
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.350906e-03	2.134
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	7.377255e-03	2.132
NRIF signals cell death from the nucleus	R-HSA-205043	7.377255e-03	2.132
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	7.918791e-03	2.101
Josephin domain DUBs	R-HSA-5689877	7.918791e-03	2.101
Pexophagy	R-HSA-9664873	7.918791e-03	2.101
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	7.940724e-03	2.100
PCP/CE pathway	R-HSA-4086400	7.970447e-03	2.099
CaM pathway	R-HSA-111997	7.975753e-03	2.098
Calmodulin induced events	R-HSA-111933	7.975753e-03	2.098
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.451801e-03	2.024
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	9.774275e-03	2.010
Sema4D in semaphorin signaling	R-HSA-400685	9.439918e-03	2.025
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.777901e-03	2.057
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.342462e-03	2.030
PKR-mediated signaling	R-HSA-9833482	9.744773e-03	2.011
Ca-dependent events	R-HSA-111996	8.217889e-03	2.085
Nephrin family interactions	R-HSA-373753	9.774275e-03	2.010
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	8.239483e-03	2.084
p53-Dependent G1 DNA Damage Response	R-HSA-69563	8.239483e-03	2.084
Degradation of CDH1	R-HSA-9766229	8.239483e-03	2.084
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	9.451801e-03	2.024
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.419710e-03	2.026
Platelet degranulation	R-HSA-114608	8.664012e-03	2.062
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	8.239483e-03	2.084
SARS-CoV-1-host interactions	R-HSA-9692914	8.738778e-03	2.059
Cleavage of the damaged purine	R-HSA-110331	9.258776e-03	2.033
Cleavage of the damaged pyrimidine	R-HSA-110329	8.217889e-03	2.085
Depyrimidination	R-HSA-73928	8.217889e-03	2.085
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.035916e-02	1.985
Switching of origins to a post-replicative state	R-HSA-69052	1.035916e-02	1.985
Intracellular signaling by second messengers	R-HSA-9006925	1.056610e-02	1.976
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.064529e-02	1.973
Depurination	R-HSA-73927	1.069383e-02	1.971
Selective autophagy	R-HSA-9663891	1.100062e-02	1.959
Myogenesis	R-HSA-525793	1.124547e-02	1.949
Metalloprotease DUBs	R-HSA-5689901	1.124547e-02	1.949
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.181867e-02	1.927
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.182338e-02	1.927
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.189917e-02	1.924
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.189917e-02	1.924
Regulation of NF-kappa B signaling	R-HSA-9758274	1.191186e-02	1.924
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.201667e-02	1.920
Diseases of Telomere Maintenance	R-HSA-9673013	1.525744e-02	1.817
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.525744e-02	1.817
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.525744e-02	1.817
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.525744e-02	1.817
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.525744e-02	1.817
RUNX3 regulates WNT signaling	R-HSA-8951430	1.490717e-02	1.827
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.490717e-02	1.827
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.395207e-02	1.855
RNA Polymerase I Transcription Termination	R-HSA-73863	1.329373e-02	1.876
Striated Muscle Contraction	R-HSA-390522	1.393568e-02	1.856
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.229166e-02	1.910
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.384684e-02	1.859
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.384684e-02	1.859
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.340716e-02	1.873
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.428635e-02	1.845
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.348403e-02	1.870
Centrosome maturation	R-HSA-380287	1.265249e-02	1.898
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.422440e-02	1.847
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.406298e-02	1.852
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.316866e-02	1.880
Integration of provirus	R-HSA-162592	1.395207e-02	1.855
Telomere Maintenance	R-HSA-157579	1.440460e-02	1.841
Signaling by ERBB2	R-HSA-1227986	1.282733e-02	1.892
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.433876e-02	1.843
Regulation of PTEN stability and activity	R-HSA-8948751	1.340716e-02	1.873
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	1.490717e-02	1.827
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.222543e-02	1.913
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.222543e-02	1.913
Death Receptor Signaling	R-HSA-73887	1.249201e-02	1.903
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.406298e-02	1.852
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.222543e-02	1.913
RNA Polymerase II Transcription Termination	R-HSA-73856	1.428635e-02	1.845
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.479097e-02	1.830
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.406298e-02	1.852
ISG15 antiviral mechanism	R-HSA-1169408	1.265249e-02	1.898
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.395207e-02	1.855
Vpu mediated degradation of CD4	R-HSA-180534	1.393568e-02	1.856
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.329373e-02	1.876
Signaling by Interleukins	R-HSA-449147	1.296718e-02	1.887
Nucleotide Excision Repair	R-HSA-5696398	1.552682e-02	1.809
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.562563e-02	1.806
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.601848e-02	1.795
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.607228e-02	1.794
Cyclin E associated events during G1/S transition	R-HSA-69202	1.645042e-02	1.784
G1/S DNA Damage Checkpoints	R-HSA-69615	1.758185e-02	1.755
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.788705e-02	1.747
VLDLR internalisation and degradation	R-HSA-8866427	1.788705e-02	1.747
Disorders of Nervous System Development	R-HSA-9697154	1.788705e-02	1.747
Pervasive developmental disorders	R-HSA-9005895	1.788705e-02	1.747
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.788705e-02	1.747
Gene Silencing by RNA	R-HSA-211000	1.811857e-02	1.742
Signaling by Hippo	R-HSA-2028269	1.812066e-02	1.742
Degradation of CRY and PER proteins	R-HSA-9932298	1.816871e-02	1.741
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.843954e-02	1.734
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.843954e-02	1.734
Regulation of Apoptosis	R-HSA-169911	1.843954e-02	1.734
Beta-catenin independent WNT signaling	R-HSA-3858494	1.896671e-02	1.722
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.989105e-02	1.701
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.031854e-02	1.692
Myoclonic epilepsy of Lafora	R-HSA-3785653	2.031854e-02	1.692
Downregulation of ERBB4 signaling	R-HSA-1253288	2.031854e-02	1.692
Modulation by Mtb of host immune system	R-HSA-9637628	2.031854e-02	1.692
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.031854e-02	1.692
Nuclear Envelope Breakdown	R-HSA-2980766	2.074348e-02	1.683
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.103397e-02	1.677
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.105021e-02	1.677
Cellular response to hypoxia	R-HSA-1234174	2.142197e-02	1.669
Ephrin signaling	R-HSA-3928664	2.193001e-02	1.659
Regulation of RAS by GAPs	R-HSA-5658442	2.199284e-02	1.658
L1CAM interactions	R-HSA-373760	2.208381e-02	1.656
Dual incision in TC-NER	R-HSA-6782135	2.297079e-02	1.639
RNA Polymerase II Transcription	R-HSA-73857	2.305963e-02	1.637
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.348351e-02	1.629
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.391659e-02	1.621
Degradation of AXIN	R-HSA-4641257	2.391659e-02	1.621
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	2.391659e-02	1.621
Signal Transduction	R-HSA-162582	2.405230e-02	1.619
Budding and maturation of HIV virion	R-HSA-162588	2.425154e-02	1.615
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.448699e-02	1.611
Meiotic recombination	R-HSA-912446	2.448699e-02	1.611
Hedgehog ligand biogenesis	R-HSA-5358346	2.448699e-02	1.611
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.834451e-02	1.548
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	2.834451e-02	1.548
ALK mutants bind TKIs	R-HSA-9700645	2.679722e-02	1.572
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	3.384825e-02	1.470
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	3.384825e-02	1.470
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.624528e-02	1.581
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.624528e-02	1.581
Signaling by EGFR in Cancer	R-HSA-1643713	3.201146e-02	1.495
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.718058e-02	1.566
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.008132e-02	1.522
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.008132e-02	1.522
Amplification of signal from the kinetochores	R-HSA-141424	3.301386e-02	1.481
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.301386e-02	1.481
Translesion Synthesis by POLH	R-HSA-110320	2.624528e-02	1.581
Regulation of necroptotic cell death	R-HSA-5675482	3.160708e-02	1.500
DAG and IP3 signaling	R-HSA-1489509	2.891951e-02	1.539
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.679722e-02	1.572
Translesion synthesis by REV1	R-HSA-110312	3.384825e-02	1.470
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	2.891951e-02	1.539
Clathrin-mediated endocytosis	R-HSA-8856828	3.117907e-02	1.506
Regulation of signaling by CBL	R-HSA-912631	2.624528e-02	1.581
Breakdown of the nuclear lamina	R-HSA-352238	3.230922e-02	1.491
Fanconi Anemia Pathway	R-HSA-6783310	2.891951e-02	1.539
Activation of BAD and translocation to mitochondria	R-HSA-111447	3.384825e-02	1.470
Macroautophagy	R-HSA-1632852	2.604960e-02	1.584
Asymmetric localization of PCP proteins	R-HSA-4608870	2.891951e-02	1.539
Activation of ATR in response to replication stress	R-HSA-176187	3.160708e-02	1.500
Cellular response to mitochondrial stress	R-HSA-9840373	2.679722e-02	1.572
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	3.319661e-02	1.479
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	3.372000e-02	1.472
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.384825e-02	1.470
Signaling by TGFB family members	R-HSA-9006936	3.035263e-02	1.518
Spry regulation of FGF signaling	R-HSA-1295596	3.384825e-02	1.470
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.891951e-02	1.539
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.992045e-02	1.524
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.384825e-02	1.470
Base-Excision Repair, AP Site Formation	R-HSA-73929	3.319661e-02	1.479
Mitotic Spindle Checkpoint	R-HSA-69618	3.396063e-02	1.469
Interactions of Rev with host cellular proteins	R-HSA-177243	3.416421e-02	1.466
2-LTR circle formation	R-HSA-164843	3.437947e-02	1.464
Folding of actin by CCT/TriC	R-HSA-390450	3.437947e-02	1.464
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.437947e-02	1.464
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.508724e-02	1.455
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.543668e-02	1.451
Recycling pathway of L1	R-HSA-437239	3.571687e-02	1.447
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	3.571687e-02	1.447
Signaling by Nuclear Receptors	R-HSA-9006931	3.624222e-02	1.441
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.648260e-02	1.438
Early Phase of HIV Life Cycle	R-HSA-162594	3.648260e-02	1.438
Ribosome-associated quality control	R-HSA-9948299	3.652250e-02	1.437
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	3.653347e-02	1.437
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.677174e-02	1.434
Interaction between L1 and Ankyrins	R-HSA-445095	3.677174e-02	1.434
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	3.677174e-02	1.434
Semaphorin interactions	R-HSA-373755	3.680939e-02	1.434
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.816422e-02	1.418
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.922946e-02	1.406
Autophagy	R-HSA-9612973	3.951545e-02	1.403
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.009850e-02	1.397
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.009850e-02	1.397
Dual Incision in GG-NER	R-HSA-5696400	4.035714e-02	1.394
Mitophagy	R-HSA-5205647	4.035714e-02	1.394
Calnexin/calreticulin cycle	R-HSA-901042	4.035714e-02	1.394
Translesion synthesis by POLI	R-HSA-5656121	4.064929e-02	1.391
Negative regulation of FLT3	R-HSA-9706369	4.064929e-02	1.391
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	4.197587e-02	1.377
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	4.244054e-02	1.372
MAP2K and MAPK activation	R-HSA-5674135	4.247163e-02	1.372
Negative regulation of MAPK pathway	R-HSA-5675221	4.247163e-02	1.372
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.308426e-02	1.366
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	4.308426e-02	1.366
DNA Damage Bypass	R-HSA-73893	4.355142e-02	1.361
Cytokine Signaling in Immune system	R-HSA-1280215	4.495843e-02	1.347
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	4.528213e-02	1.344
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.570761e-02	1.340
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.570761e-02	1.340
COPI-mediated anterograde transport	R-HSA-6807878	4.613847e-02	1.336
Signaling by NOTCH4	R-HSA-9013694	4.669653e-02	1.331
PIP3 activates AKT signaling	R-HSA-1257604	4.707206e-02	1.327
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	4.763489e-02	1.322
Late endosomal microautophagy	R-HSA-9615710	4.763489e-02	1.322
Translesion synthesis by POLK	R-HSA-5655862	4.822057e-02	1.317
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	4.897580e-02	1.310
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	5.114293e-02	1.291
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.245919e-02	1.280
Activation of NF-kappaB in B cells	R-HSA-1169091	5.247824e-02	1.280
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.270612e-02	1.278
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.291438e-02	1.276
Activation of BH3-only proteins	R-HSA-114452	5.375757e-02	1.270
Regulation of TP53 Expression	R-HSA-6804754	5.408542e-02	1.267
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	5.408542e-02	1.267
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	5.408542e-02	1.267
Signaling by NOTCH1	R-HSA-1980143	5.433569e-02	1.265
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.609708e-02	1.251
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.609708e-02	1.251
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.609708e-02	1.251
Ovarian tumor domain proteases	R-HSA-5689896	5.627405e-02	1.250
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.627405e-02	1.250
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.656943e-02	1.247
Kinesins	R-HSA-983189	5.675572e-02	1.246
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.675572e-02	1.246
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.675572e-02	1.246
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.675572e-02	1.246
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.675572e-02	1.246
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.675572e-02	1.246
Synthesis of DNA	R-HSA-69239	5.729096e-02	1.242
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.731180e-02	1.242
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	7.961463e-02	1.099
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	7.961463e-02	1.099
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	7.961463e-02	1.099
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.766267e-02	1.170
Type I hemidesmosome assembly	R-HSA-446107	8.431466e-02	1.074
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	8.431466e-02	1.074
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	7.588928e-02	1.120
Deadenylation of mRNA	R-HSA-429947	6.380924e-02	1.195
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	6.380924e-02	1.195
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	8.625371e-02	1.064
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.625371e-02	1.064
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	6.035042e-02	1.219
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.885927e-02	1.162
Formation of a pool of free 40S subunits	R-HSA-72689	7.509310e-02	1.124
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.483400e-02	1.188
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	6.062698e-02	1.217
Post NMDA receptor activation events	R-HSA-438064	6.923141e-02	1.160
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.235335e-02	1.205
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.100710e-02	1.091
EGFR downregulation	R-HSA-182971	6.035042e-02	1.219
Signaling by EGFR	R-HSA-177929	7.983120e-02	1.098
G0 and Early G1	R-HSA-1538133	6.741761e-02	1.171
PLC beta mediated events	R-HSA-112043	6.154354e-02	1.211
Membrane binding and targetting of GAG proteins	R-HSA-174490	7.588928e-02	1.120
Signal transduction by L1	R-HSA-445144	8.625371e-02	1.064
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.235335e-02	1.205
Translation	R-HSA-72766	6.780121e-02	1.169
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.514028e-02	1.124
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	6.385783e-02	1.195
ROBO receptors bind AKAP5	R-HSA-9010642	8.431466e-02	1.074
Response of endothelial cells to shear stress	R-HSA-9860931	7.596607e-02	1.119
Circadian clock	R-HSA-9909396	6.582396e-02	1.182
MAPK family signaling cascades	R-HSA-5683057	7.642054e-02	1.117
ER-Phagosome pathway	R-HSA-1236974	7.860524e-02	1.105
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.569632e-02	1.182
Cellular responses to mechanical stimuli	R-HSA-9855142	8.526686e-02	1.069
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	7.596607e-02	1.119
Vesicle-mediated transport	R-HSA-5653656	7.455026e-02	1.128
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	7.970949e-02	1.098
Organelle biogenesis and maintenance	R-HSA-1852241	5.887581e-02	1.230
Hedgehog 'off' state	R-HSA-5610787	5.978620e-02	1.223
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	6.658848e-02	1.177
NRAGE signals death through JNK	R-HSA-193648	7.983120e-02	1.098
Muscle contraction	R-HSA-397014	7.076260e-02	1.150
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.741761e-02	1.171
Uptake and function of diphtheria toxin	R-HSA-5336415	6.766267e-02	1.170
Interleukin-1 signaling	R-HSA-9020702	6.358843e-02	1.197
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	6.035042e-02	1.219
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.385783e-02	1.195
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.385783e-02	1.195
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.983120e-02	1.098
Cellular response to chemical stress	R-HSA-9711123	6.987430e-02	1.156
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	6.380924e-02	1.195
Neurodegenerative Diseases	R-HSA-8863678	6.380924e-02	1.195
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.480096e-02	1.188
IRAK1 recruits IKK complex	R-HSA-937039	6.385783e-02	1.195
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.385783e-02	1.195
Signaling by ALK	R-HSA-201556	6.882724e-02	1.162
SARS-CoV-1 Infection	R-HSA-9678108	6.782153e-02	1.169
Platelet activation, signaling and aggregation	R-HSA-76002	8.632424e-02	1.064
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	8.871978e-02	1.052
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	8.871978e-02	1.052
Loss of Function of TP53 in Cancer	R-HSA-9723907	8.871978e-02	1.052
Gap junction trafficking and regulation	R-HSA-157858	8.872407e-02	1.052
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.872407e-02	1.052
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.897174e-02	1.051
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.897174e-02	1.051
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.897174e-02	1.051
EPHA-mediated growth cone collapse	R-HSA-3928663	9.048419e-02	1.043
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	9.048419e-02	1.043
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.048419e-02	1.043
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.164319e-02	1.038
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.164319e-02	1.038
G-protein mediated events	R-HSA-112040	9.574458e-02	1.019
Unfolded Protein Response (UPR)	R-HSA-381119	9.736802e-02	1.012
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.765392e-02	1.010
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.765392e-02	1.010
Basigin interactions	R-HSA-210991	9.765392e-02	1.010
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.765392e-02	1.010
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.869100e-02	1.006
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.869100e-02	1.006
Eukaryotic Translation Elongation	R-HSA-156842	9.970471e-02	1.001
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.991573e-02	1.000
Antigen processing-Cross presentation	R-HSA-1236975	9.991573e-02	1.000
ABC-family proteins mediated transport	R-HSA-382556	9.998330e-02	1.000
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.005352e-01	0.998
HIV elongation arrest and recovery	R-HSA-167287	1.005352e-01	0.998
Pausing and recovery of HIV elongation	R-HSA-167290	1.005352e-01	0.998
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.025197e-01	0.989
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.025197e-01	0.989
MASTL Facilitates Mitotic Progression	R-HSA-2465910	1.025197e-01	0.989
Calcineurin activates NFAT	R-HSA-2025928	1.025197e-01	0.989
Unwinding of DNA	R-HSA-176974	1.025197e-01	0.989
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.025197e-01	0.989
Golgi-to-ER retrograde transport	R-HSA-8856688	1.029565e-01	0.987
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.030582e-01	0.987
DCC mediated attractive signaling	R-HSA-418885	1.030582e-01	0.987
Protein methylation	R-HSA-8876725	1.030582e-01	0.987
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.030582e-01	0.987
MITF-M-regulated melanocyte development	R-HSA-9730414	1.055783e-01	0.976
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.080604e-01	0.966
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.080604e-01	0.966
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	1.080604e-01	0.966
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.080604e-01	0.966
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.080604e-01	0.966
MTF1 activates gene expression	R-HSA-5660489	1.080604e-01	0.966
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.080604e-01	0.966
HCMV Early Events	R-HSA-9609690	1.095296e-01	0.960
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	1.097726e-01	0.960
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.097726e-01	0.960
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.097726e-01	0.960
Assembly Of The HIV Virion	R-HSA-175474	1.097726e-01	0.960
FLT3 signaling in disease	R-HSA-9682385	1.098524e-01	0.959
ABC transporter disorders	R-HSA-5619084	1.105925e-01	0.956
TCR signaling	R-HSA-202403	1.106744e-01	0.956
Termination of translesion DNA synthesis	R-HSA-5656169	1.111474e-01	0.954
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.112112e-01	0.954
XBP1(S) activates chaperone genes	R-HSA-381038	1.112696e-01	0.954
Neurexins and neuroligins	R-HSA-6794361	1.116420e-01	0.952
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.116420e-01	0.952
Gap junction trafficking	R-HSA-190828	1.159758e-01	0.936
G1 Phase	R-HSA-69236	1.159758e-01	0.936
Cyclin D associated events in G1	R-HSA-69231	1.159758e-01	0.936
Viral Infection Pathways	R-HSA-9824446	1.179754e-01	0.928
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.180930e-01	0.928
Class I peroxisomal membrane protein import	R-HSA-9603798	1.180930e-01	0.928
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.180930e-01	0.928
Regulation of BACH1 activity	R-HSA-9708530	1.180930e-01	0.928
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.197246e-01	0.922
CASP4 inflammasome assembly	R-HSA-9948001	1.221227e-01	0.913
Apoptosis induced DNA fragmentation	R-HSA-140342	1.221227e-01	0.913
RNA Polymerase III Transcription Initiation	R-HSA-76046	1.223052e-01	0.913
Activation of the pre-replicative complex	R-HSA-68962	1.223052e-01	0.913
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.225816e-01	0.912
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	1.225816e-01	0.912
mTORC1-mediated signalling	R-HSA-166208	1.225816e-01	0.912
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.231636e-01	0.910
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.238071e-01	0.907
Regulation of mitotic cell cycle	R-HSA-453276	1.238071e-01	0.907
Hedgehog 'on' state	R-HSA-5632684	1.238071e-01	0.907
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.238071e-01	0.907
Cilium Assembly	R-HSA-5617833	1.247101e-01	0.904
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.275381e-01	0.894
SLC-mediated transport of inorganic anions	R-HSA-9958790	1.300372e-01	0.886
TGFBR2 MSI Frameshift Mutants in Cancer	R-HSA-3642279	1.695731e-01	0.771
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.695731e-01	0.771
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	1.695731e-01	0.771
Defective GALM causes GALAC4	R-HSA-9931929	1.695731e-01	0.771
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.695731e-01	0.771
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.695731e-01	0.771
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.695731e-01	0.771
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	1.695731e-01	0.771
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.695731e-01	0.771
MyD88 deficiency (TLR5)	R-HSA-5602680	2.432572e-01	0.614
Defective SLC26A2 causes chondrodysplasias	R-HSA-3560792	2.432572e-01	0.614
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.432572e-01	0.614
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.432572e-01	0.614
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.432572e-01	0.614
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.432572e-01	0.614
Signaling by TCF7L2 mutants	R-HSA-5339700	2.432572e-01	0.614
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.387051e-01	0.858
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	1.387051e-01	0.858
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.709352e-01	0.767
CDC6 association with the ORC:origin complex	R-HSA-68689	1.709352e-01	0.767
IkBA variant leads to EDA-ID	R-HSA-5603029	1.709352e-01	0.767
Autointegration results in viral DNA circles	R-HSA-177539	2.042286e-01	0.690
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.042286e-01	0.690
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	1.429619e-01	0.845
Signaling by APC mutants	R-HSA-4839744	1.429619e-01	0.845
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.429619e-01	0.845
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.429619e-01	0.845
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.429619e-01	0.845
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.648725e-01	0.783
Signaling by GSK3beta mutants	R-HSA-5339716	1.648725e-01	0.783
NOSTRIN mediated eNOS trafficking	R-HSA-203641	2.381434e-01	0.623
Recycling of eIF2:GDP	R-HSA-72731	2.381434e-01	0.623
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.876910e-01	0.727
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.876910e-01	0.727
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.876910e-01	0.727
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.876910e-01	0.727
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.876910e-01	0.727
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.112575e-01	0.675
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.682377e-01	0.774
PKA activation	R-HSA-163615	1.682377e-01	0.774
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.360490e-01	0.866
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	1.360490e-01	0.866
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	1.360490e-01	0.866
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.863940e-01	0.730
Co-inhibition by CTLA4	R-HSA-389513	2.051450e-01	0.688
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.600254e-01	0.585
Beta-catenin phosphorylation cascade	R-HSA-196299	2.600254e-01	0.585
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.407772e-01	0.851
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.957411e-01	0.708
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.957411e-01	0.708
Cristae formation	R-HSA-8949613	1.957411e-01	0.708
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.719856e-01	0.765
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.519299e-01	0.818
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.519299e-01	0.818
mRNA Splicing - Minor Pathway	R-HSA-72165	1.347718e-01	0.870
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.441224e-01	0.612
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.119081e-01	0.674
Formation of the Early Elongation Complex	R-HSA-113418	2.119081e-01	0.674
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.855469e-01	0.732
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.995100e-01	0.700
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.138448e-01	0.670
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.454167e-01	0.610
Metabolism of non-coding RNA	R-HSA-194441	1.763706e-01	0.754
snRNP Assembly	R-HSA-191859	1.763706e-01	0.754
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.531780e-01	0.815
Chaperonin-mediated protein folding	R-HSA-390466	1.885716e-01	0.725
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.851213e-01	0.733
Neutrophil degranulation	R-HSA-6798695	2.160496e-01	0.665
Transcription of the HIV genome	R-HSA-167172	1.752229e-01	0.756
Transcriptional regulation by RUNX2	R-HSA-8878166	2.604400e-01	0.584
RNA Polymerase III Transcription	R-HSA-74158	2.138448e-01	0.670
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.640157e-01	0.785
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.640157e-01	0.785
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.640157e-01	0.785
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.682377e-01	0.774
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	1.634789e-01	0.787
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.454167e-01	0.610
Integrin signaling	R-HSA-354192	1.588546e-01	0.799
mRNA Capping	R-HSA-72086	2.284823e-01	0.641
Protein folding	R-HSA-391251	2.449397e-01	0.611
Nectin/Necl trans heterodimerization	R-HSA-420597	1.387051e-01	0.858
Lysosome Vesicle Biogenesis	R-HSA-432720	2.138448e-01	0.670
Protein localization	R-HSA-9609507	2.473501e-01	0.607
Regulation of TNFR1 signaling	R-HSA-5357905	1.347718e-01	0.870
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.587682e-01	0.587
Microbial factors inhibit CASP4 activity	R-HSA-9956593	2.112575e-01	0.675
RAF activation	R-HSA-5673000	1.855469e-01	0.732
TNF signaling	R-HSA-75893	2.482954e-01	0.605
Nuclear import of Rev protein	R-HSA-180746	1.855469e-01	0.732
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.284823e-01	0.641
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.657613e-01	0.781
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.407772e-01	0.851
MTOR signalling	R-HSA-165159	1.876938e-01	0.727
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.519299e-01	0.818
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.519299e-01	0.818
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	1.709352e-01	0.767
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.709352e-01	0.767
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.648725e-01	0.783
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.400206e-01	0.620
Heme signaling	R-HSA-9707616	2.084115e-01	0.681
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.550079e-01	0.810
Rap1 signalling	R-HSA-392517	1.863940e-01	0.730
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.634789e-01	0.787
Generic Transcription Pathway	R-HSA-212436	1.827478e-01	0.738
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.199449e-01	0.658
Ion homeostasis	R-HSA-5578775	2.482954e-01	0.605
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.199449e-01	0.658
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.705405e-01	0.768
MyD88-independent TLR4 cascade	R-HSA-166166	1.705405e-01	0.768
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.199449e-01	0.658
Inhibition of PKR	R-HSA-169131	1.695731e-01	0.771
Manipulation of host energy metabolism	R-HSA-9636667	2.432572e-01	0.614
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.432572e-01	0.614
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	1.709352e-01	0.767
Bicarbonate transporters	R-HSA-425381	1.429619e-01	0.845
Signaling by AMER1 mutants	R-HSA-4839748	1.648725e-01	0.783
Signaling by AXIN mutants	R-HSA-4839735	1.648725e-01	0.783
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	2.381434e-01	0.623
Regulation of FZD by ubiquitination	R-HSA-4641263	1.507527e-01	0.822
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.519299e-01	0.818
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.358324e-01	0.867
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.340138e-01	0.873
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.305062e-01	0.884
Interferon Signaling	R-HSA-913531	2.032256e-01	0.692
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.709352e-01	0.767
Nef and signal transduction	R-HSA-164944	2.042286e-01	0.690
CHL1 interactions	R-HSA-447041	2.381434e-01	0.623
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.381434e-01	0.623
Signaling by Hedgehog	R-HSA-5358351	2.015137e-01	0.696
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.800273e-01	0.745
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.349184e-01	0.629
Protein-protein interactions at synapses	R-HSA-6794362	1.629053e-01	0.788
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.119081e-01	0.674
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.284823e-01	0.641
Glycolysis	R-HSA-70171	1.585995e-01	0.800
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.042286e-01	0.690
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.244135e-01	0.649
RAS processing	R-HSA-9648002	2.587682e-01	0.587
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.587682e-01	0.587
RMTs methylate histone arginines	R-HSA-3214858	2.132652e-01	0.671
Mitochondrial biogenesis	R-HSA-1592230	1.672884e-01	0.777
Signaling by TGFBR3	R-HSA-9839373	1.347718e-01	0.870
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.305356e-01	0.884
Signaling by PTK6	R-HSA-8848021	1.305356e-01	0.884
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	2.112575e-01	0.675
Signal regulatory protein family interactions	R-HSA-391160	2.354178e-01	0.628
Glycogen metabolism	R-HSA-8982491	1.519299e-01	0.818
PECAM1 interactions	R-HSA-210990	1.429619e-01	0.845
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.855469e-01	0.732
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	2.110977e-01	0.676
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.340138e-01	0.873
Signaling by NOTCH2	R-HSA-1980145	1.855469e-01	0.732
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	2.311089e-01	0.636
Transcriptional Regulation by MECP2	R-HSA-8986944	2.254695e-01	0.647
Interleukin-1 family signaling	R-HSA-446652	1.724448e-01	0.763
Sodium-coupled phosphate cotransporters	R-HSA-427652	1.709352e-01	0.767
MECP2 regulates transcription factors	R-HSA-9022707	2.381434e-01	0.623
TGFBR3 expression	R-HSA-9839394	1.648121e-01	0.783
Negative regulation of MET activity	R-HSA-6807004	2.051450e-01	0.688
Downstream TCR signaling	R-HSA-202424	2.159785e-01	0.666
Influenza Infection	R-HSA-168255	1.665916e-01	0.778
Zinc transporters	R-HSA-435354	2.354178e-01	0.628
Response to metal ions	R-HSA-5660526	1.340138e-01	0.873
Plasma lipoprotein clearance	R-HSA-8964043	2.587682e-01	0.587
Potential therapeutics for SARS	R-HSA-9679191	1.602026e-01	0.795
Signaling by NOTCH3	R-HSA-9012852	2.357160e-01	0.628
G1/S-Specific Transcription	R-HSA-69205	2.138448e-01	0.670
Specification of primordial germ cells	R-HSA-9827857	1.507527e-01	0.822
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.709352e-01	0.767
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.340138e-01	0.873
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.441224e-01	0.612
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.682377e-01	0.774
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.244135e-01	0.649
MITF-M-dependent gene expression	R-HSA-9856651	2.249282e-01	0.648
Signaling by PDGFR in disease	R-HSA-9671555	2.441224e-01	0.612
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.254695e-01	0.647
Base Excision Repair	R-HSA-73884	1.383806e-01	0.859
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.467941e-01	0.833
Oncogene Induced Senescence	R-HSA-2559585	1.995100e-01	0.700
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.482768e-01	0.605
IRE1alpha activates chaperones	R-HSA-381070	1.531780e-01	0.815
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.482954e-01	0.605
Non-canonical inflammasome activation	R-HSA-9686114	2.354178e-01	0.628
Glycogen storage diseases	R-HSA-3229121	1.507527e-01	0.822
Glycogen synthesis	R-HSA-3322077	2.051450e-01	0.688
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.610853e-01	0.583
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.626642e-01	0.581
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.626642e-01	0.581
Trafficking of AMPA receptors	R-HSA-399719	2.626642e-01	0.581
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.626642e-01	0.581
Evasion by RSV of host interferon responses	R-HSA-9833109	2.626642e-01	0.581
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	2.641957e-01	0.578
FGFR2 alternative splicing	R-HSA-6803529	2.641957e-01	0.578
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.641957e-01	0.578
Notch-HLH transcription pathway	R-HSA-350054	2.641957e-01	0.578
Co-stimulation by CD28	R-HSA-389356	2.677759e-01	0.572
MET receptor recycling	R-HSA-8875656	2.723076e-01	0.565
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.723076e-01	0.565
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	2.723076e-01	0.565
HIV Transcription Elongation	R-HSA-167169	2.742753e-01	0.562
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.742753e-01	0.562
Opioid Signalling	R-HSA-111885	2.767425e-01	0.558
Regulated Necrosis	R-HSA-5218859	2.785435e-01	0.555
DNA strand elongation	R-HSA-69190	2.801778e-01	0.553
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	2.801778e-01	0.553
G alpha (12/13) signalling events	R-HSA-416482	2.817461e-01	0.550
Syndecan interactions	R-HSA-3000170	2.845591e-01	0.546
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.849419e-01	0.545
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	2.849419e-01	0.545
Killing mechanisms	R-HSA-9664420	2.849419e-01	0.545
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.849419e-01	0.545
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.849419e-01	0.545
Peroxisomal protein import	R-HSA-9033241	2.872230e-01	0.542
Deadenylation-dependent mRNA decay	R-HSA-429914	2.872230e-01	0.542
FLT3 Signaling	R-HSA-9607240	2.899945e-01	0.538
RAF/MAP kinase cascade	R-HSA-5673001	2.917768e-01	0.535
Peptide chain elongation	R-HSA-156902	2.950194e-01	0.530
IPs transport between nucleus and cytosol	R-HSA-1855170	2.979111e-01	0.526
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.979111e-01	0.526
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.979111e-01	0.526
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.979111e-01	0.526
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.979111e-01	0.526
HCMV Infection	R-HSA-9609646	3.045861e-01	0.516
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.051404e-01	0.516
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.058934e-01	0.514
Translation of Structural Proteins	R-HSA-9683701	3.058934e-01	0.514
ARMS-mediated activation	R-HSA-170984	3.064102e-01	0.514
WNT mediated activation of DVL	R-HSA-201688	3.064102e-01	0.514
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	3.064102e-01	0.514
Inactivation of CDC42 and RAC1	R-HSA-428543	3.064102e-01	0.514
Regulation of CDH11 gene transcription	R-HSA-9762293	3.064102e-01	0.514
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.064102e-01	0.514
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	3.064102e-01	0.514
Respiratory syncytial virus genome replication	R-HSA-9834752	3.064102e-01	0.514
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.064102e-01	0.514
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.100387e-01	0.509
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.104072e-01	0.508
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.104072e-01	0.508
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.158183e-01	0.501
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.158183e-01	0.501
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.169867e-01	0.499
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.286535e-01	0.483
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.338546e-01	0.476
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.338546e-01	0.476
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.338546e-01	0.476
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.351967e-01	0.475
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.351967e-01	0.475
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.351967e-01	0.475
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.351967e-01	0.475
MAPK1/MAPK3 signaling	R-HSA-5684996	3.356284e-01	0.474
Glucose metabolism	R-HSA-70326	3.361840e-01	0.473
Response of Mtb to phagocytosis	R-HSA-9637690	3.381019e-01	0.471
Binding and entry of HIV virion	R-HSA-173107	3.401934e-01	0.468
MET activates RAP1 and RAC1	R-HSA-8875555	3.401934e-01	0.468
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	3.401934e-01	0.468
EGFR Transactivation by Gastrin	R-HSA-2179392	3.401934e-01	0.468
Regulation of CDH11 function	R-HSA-9762292	3.401934e-01	0.468
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.401934e-01	0.468
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.401934e-01	0.468
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.401934e-01	0.468
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	3.466822e-01	0.460
Suppression of phagosomal maturation	R-HSA-9637687	3.466822e-01	0.460
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.469258e-01	0.460
PERK regulates gene expression	R-HSA-381042	3.519766e-01	0.453
Developmental Biology	R-HSA-1266738	3.530457e-01	0.452
Proteasome assembly	R-HSA-9907900	3.543487e-01	0.451
Ion transport by P-type ATPases	R-HSA-936837	3.549428e-01	0.450
GAB1 signalosome	R-HSA-180292	3.603069e-01	0.443
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.603069e-01	0.443
Mismatch Repair	R-HSA-5358508	3.603069e-01	0.443
Polo-like kinase mediated events	R-HSA-156711	3.603069e-01	0.443
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.603069e-01	0.443
Transport of connexons to the plasma membrane	R-HSA-190872	3.603069e-01	0.443
Platelet sensitization by LDL	R-HSA-432142	3.603069e-01	0.443
ER to Golgi Anterograde Transport	R-HSA-199977	3.674229e-01	0.435
Hemostasis	R-HSA-109582	3.677320e-01	0.434
SARS-CoV-2-host interactions	R-HSA-9705683	3.679770e-01	0.434
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.700250e-01	0.432
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.706497e-01	0.431
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.706497e-01	0.431
Axonal growth stimulation	R-HSA-209563	3.716022e-01	0.430
Defective ABCD4 causes MAHCJ	R-HSA-5683329	3.716022e-01	0.430
IRAK4 deficiency (TLR5)	R-HSA-5603037	3.716022e-01	0.430
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	3.716022e-01	0.430
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.716022e-01	0.430
Cellular response to starvation	R-HSA-9711097	3.733849e-01	0.428
Formation of the posterior neural plate	R-HSA-9832991	3.734454e-01	0.428
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.765695e-01	0.424
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.796662e-01	0.421
SARS-CoV Infections	R-HSA-9679506	3.833675e-01	0.416
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.852704e-01	0.414
The NLRP3 inflammasome	R-HSA-844456	3.852704e-01	0.414
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.852704e-01	0.414
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.862017e-01	0.413
Regulation of pyruvate metabolism	R-HSA-9861718	3.869753e-01	0.412
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.895694e-01	0.409
MHC class II antigen presentation	R-HSA-2132295	3.969044e-01	0.401
Eukaryotic Translation Termination	R-HSA-72764	3.978382e-01	0.400
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.059947e-01	0.391
Proton-coupled monocarboxylate transport	R-HSA-433692	4.059947e-01	0.391
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.059947e-01	0.391
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.059947e-01	0.391
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.059947e-01	0.391
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	4.064461e-01	0.391
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.090008e-01	0.388
DARPP-32 events	R-HSA-180024	4.090008e-01	0.388
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.090008e-01	0.388
Post-chaperonin tubulin folding pathway	R-HSA-389977	4.099980e-01	0.387
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.099980e-01	0.387
Formation of definitive endoderm	R-HSA-9823730	4.099980e-01	0.387
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.103282e-01	0.387
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.115718e-01	0.386
Sensory processing of sound	R-HSA-9659379	4.189935e-01	0.378
NGF-stimulated transcription	R-HSA-9031628	4.195870e-01	0.377
Metal ion SLC transporters	R-HSA-425410	4.195870e-01	0.377
Pentose phosphate pathway	R-HSA-71336	4.245089e-01	0.372
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	4.245089e-01	0.372
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.273700e-01	0.369
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.273700e-01	0.369
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.273700e-01	0.369
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	4.273700e-01	0.369
Regulation of gap junction activity	R-HSA-191650	4.273700e-01	0.369
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.273700e-01	0.369
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.273700e-01	0.369
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.273700e-01	0.369
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.273700e-01	0.369
NADE modulates death signalling	R-HSA-205025	4.273700e-01	0.369
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.295498e-01	0.367
Interleukin-37 signaling	R-HSA-9008059	4.295498e-01	0.367
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.319833e-01	0.365
Signaling by FGFR2	R-HSA-5654738	4.319833e-01	0.365
Post-translational protein phosphorylation	R-HSA-8957275	4.328122e-01	0.364
TNFR1-induced proapoptotic signaling	R-HSA-5357786	4.344102e-01	0.362
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.377042e-01	0.359
Scavenging by Class F Receptors	R-HSA-3000484	4.377042e-01	0.359
Leading Strand Synthesis	R-HSA-69109	4.377042e-01	0.359
Polymerase switching	R-HSA-69091	4.377042e-01	0.359
Metallothioneins bind metals	R-HSA-5661231	4.377042e-01	0.359
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.384889e-01	0.358
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.424655e-01	0.354
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.496023e-01	0.347
Cargo trafficking to the periciliary membrane	R-HSA-5620920	4.518241e-01	0.345
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.584368e-01	0.339
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	4.584368e-01	0.339
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.584368e-01	0.339
Ribavirin ADME	R-HSA-9755088	4.584368e-01	0.339
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.584368e-01	0.339
Viral Messenger RNA Synthesis	R-HSA-168325	4.594331e-01	0.338
MAP kinase activation	R-HSA-450294	4.594331e-01	0.338
Transcriptional Regulation by VENTX	R-HSA-8853884	4.602836e-01	0.337
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.602836e-01	0.337
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	4.622106e-01	0.335
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.648422e-01	0.333
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.648422e-01	0.333
Extra-nuclear estrogen signaling	R-HSA-9009391	4.676718e-01	0.330
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	4.684668e-01	0.329
Replication of the SARS-CoV-1 genome	R-HSA-9682706	4.684668e-01	0.329
Signaling by WNT in cancer	R-HSA-4791275	4.700202e-01	0.328
Diseases of mitotic cell cycle	R-HSA-9675126	4.700202e-01	0.328
tRNA processing in the nucleus	R-HSA-6784531	4.741427e-01	0.324
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.779326e-01	0.321
HIV Transcription Initiation	R-HSA-167161	4.779326e-01	0.321
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.779326e-01	0.321
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	4.781917e-01	0.320
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	R-HSA-5619067	4.781917e-01	0.320
Activation of AKT2	R-HSA-165158	4.781917e-01	0.320
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	4.781917e-01	0.320
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.781917e-01	0.320
NTRK2 activates RAC1	R-HSA-9032759	4.781917e-01	0.320
Muscarinic acetylcholine receptors	R-HSA-390648	4.781917e-01	0.320
NrCAM interactions	R-HSA-447038	4.781917e-01	0.320
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.781917e-01	0.320
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.781917e-01	0.320
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	4.781917e-01	0.320
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.781917e-01	0.320
Adaptive Immune System	R-HSA-1280218	4.785278e-01	0.320
Ca2+ pathway	R-HSA-4086398	4.792224e-01	0.319
Toll-like Receptor Cascades	R-HSA-168898	4.860098e-01	0.313
Nuclear RNA decay	R-HSA-9930044	4.898583e-01	0.310
FGFR1 mutant receptor activation	R-HSA-1839124	4.898583e-01	0.310
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.898583e-01	0.310
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	4.898583e-01	0.310
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	4.898583e-01	0.310
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	4.898583e-01	0.310
Signaling by ERBB4	R-HSA-1236394	4.927970e-01	0.307
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.937587e-01	0.306
Cytosolic tRNA aminoacylation	R-HSA-379716	4.953846e-01	0.305
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.965291e-01	0.304
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.965291e-01	0.304
Removal of the Flap Intermediate	R-HSA-69166	4.982007e-01	0.303
Retrograde neurotrophin signalling	R-HSA-177504	4.982007e-01	0.303
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.982007e-01	0.303
Regulation of KIT signaling	R-HSA-1433559	4.982007e-01	0.303
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	4.982007e-01	0.303
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	4.982007e-01	0.303
HDL assembly	R-HSA-8963896	4.982007e-01	0.303
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	4.982007e-01	0.303
C-type lectin receptors (CLRs)	R-HSA-5621481	4.988066e-01	0.302
Adipogenesis	R-HSA-9843745	4.990788e-01	0.302
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	5.014436e-01	0.300
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.032305e-01	0.298
Iron uptake and transport	R-HSA-917937	5.062700e-01	0.296
Disorders of transmembrane transporters	R-HSA-5619115	5.115624e-01	0.291
RNA Polymerase II Promoter Escape	R-HSA-73776	5.126133e-01	0.290
Signaling by SCF-KIT	R-HSA-1433557	5.126133e-01	0.290
TBC/RABGAPs	R-HSA-8854214	5.126133e-01	0.290
Signaling by FGFR4	R-HSA-5654743	5.126133e-01	0.290
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.245056e-01	0.280
Plus-strand DNA synthesis	R-HSA-164525	5.245056e-01	0.280
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.245056e-01	0.280
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.245056e-01	0.280
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.245056e-01	0.280
Signaling by MAPK mutants	R-HSA-9652817	5.245056e-01	0.280
Pentose phosphate pathway disease	R-HSA-6791465	5.245056e-01	0.280
PDE3B signalling	R-HSA-165160	5.245056e-01	0.280
Cam-PDE 1 activation	R-HSA-111957	5.245056e-01	0.280
PKB-mediated events	R-HSA-109703	5.245056e-01	0.280
Noncanonical activation of NOTCH3	R-HSA-9017802	5.245056e-01	0.280
Signalling to p38 via RIT and RIN	R-HSA-187706	5.245056e-01	0.280
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.245056e-01	0.280
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.245056e-01	0.280
Relaxin receptors	R-HSA-444821	5.245056e-01	0.280
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.245056e-01	0.280
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.245056e-01	0.280
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.263440e-01	0.279
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.268464e-01	0.278
RNA Polymerase III Chain Elongation	R-HSA-73780	5.268464e-01	0.278
Processive synthesis on the lagging strand	R-HSA-69183	5.268464e-01	0.278
Formation of the anterior neural plate	R-HSA-9823739	5.268464e-01	0.278
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.268464e-01	0.278
TRAF6 mediated NF-kB activation	R-HSA-933542	5.276312e-01	0.278
CD209 (DC-SIGN) signaling	R-HSA-5621575	5.276312e-01	0.278
eNOS activation	R-HSA-203615	5.285611e-01	0.277
NOD1/2 Signaling Pathway	R-HSA-168638	5.285611e-01	0.277
Netrin-1 signaling	R-HSA-373752	5.295949e-01	0.276
Translation of Structural Proteins	R-HSA-9694635	5.328597e-01	0.273
Detoxification of Reactive Oxygen Species	R-HSA-3299685	5.458687e-01	0.263
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.463076e-01	0.263
Signaling by FGFR3	R-HSA-5654741	5.463076e-01	0.263
Somitogenesis	R-HSA-9824272	5.463076e-01	0.263
Long-term potentiation	R-HSA-9620244	5.495832e-01	0.260
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.495832e-01	0.260
Tight junction interactions	R-HSA-420029	5.495832e-01	0.260
Acyl chain remodelling of PS	R-HSA-1482801	5.495832e-01	0.260
Glycogen breakdown (glycogenolysis)	R-HSA-70221	5.495832e-01	0.260
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	5.495832e-01	0.260
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.495832e-01	0.260
HDMs demethylate histones	R-HSA-3214842	5.495832e-01	0.260
Interleukin-7 signaling	R-HSA-1266695	5.495832e-01	0.260
Phosphorylation of the APC/C	R-HSA-176412	5.543627e-01	0.256
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.543627e-01	0.256
Activation of SMO	R-HSA-5635838	5.543627e-01	0.256
Prolonged ERK activation events	R-HSA-169893	5.543627e-01	0.256
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.543627e-01	0.256
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.543627e-01	0.256
HCMV Late Events	R-HSA-9610379	5.592864e-01	0.252
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.667114e-01	0.247
Signaling by LTK in cancer	R-HSA-9842640	5.667114e-01	0.247
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.667114e-01	0.247
Erythropoietin activates STAT5	R-HSA-9027283	5.667114e-01	0.247
Uncoating of the HIV Virion	R-HSA-162585	5.667114e-01	0.247
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	5.667114e-01	0.247
CREB phosphorylation	R-HSA-199920	5.667114e-01	0.247
G2/M DNA replication checkpoint	R-HSA-69478	5.667114e-01	0.247
Neurofascin interactions	R-HSA-447043	5.667114e-01	0.247
Lactose synthesis	R-HSA-5653890	5.667114e-01	0.247
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.667114e-01	0.247
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	5.683543e-01	0.245
FOXO-mediated transcription	R-HSA-9614085	5.696891e-01	0.244
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.709212e-01	0.243
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.709212e-01	0.243
TRP channels	R-HSA-3295583	5.709212e-01	0.243
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.709212e-01	0.243
Signaling by MET	R-HSA-6806834	5.716781e-01	0.243
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.807245e-01	0.236
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.807245e-01	0.236
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.807245e-01	0.236
tRNA modification in the mitochondrion	R-HSA-6787450	5.807245e-01	0.236
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.807245e-01	0.236
Coenzyme A biosynthesis	R-HSA-196783	5.807245e-01	0.236
Acetylcholine regulates insulin secretion	R-HSA-399997	5.807245e-01	0.236
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	5.807245e-01	0.236
Interleukin-17 signaling	R-HSA-448424	5.867480e-01	0.232
CD28 dependent PI3K/Akt signaling	R-HSA-389357	5.916207e-01	0.228
Selenocysteine synthesis	R-HSA-2408557	5.921965e-01	0.228
Metabolism of polyamines	R-HSA-351202	6.042777e-01	0.219
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.051732e-01	0.218
TRIF-mediated programmed cell death	R-HSA-2562578	6.051732e-01	0.218
Disinhibition of SNARE formation	R-HSA-114516	6.051732e-01	0.218
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.051732e-01	0.218
PTK6 Expression	R-HSA-8849473	6.051732e-01	0.218
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.051732e-01	0.218
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.051732e-01	0.218
VLDL clearance	R-HSA-8964046	6.051732e-01	0.218
Cation-coupled Chloride cotransporters	R-HSA-426117	6.051732e-01	0.218
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.051732e-01	0.218
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.051732e-01	0.218
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.051732e-01	0.218
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.059199e-01	0.218
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.059199e-01	0.218
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.059199e-01	0.218
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.059199e-01	0.218
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.059199e-01	0.218
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.116626e-01	0.213
Phase 0 - rapid depolarisation	R-HSA-5576892	6.116626e-01	0.213
Inflammasomes	R-HSA-622312	6.116626e-01	0.213
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.130016e-01	0.213
Viral mRNA Translation	R-HSA-192823	6.141455e-01	0.212
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	6.183906e-01	0.209
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	6.197826e-01	0.208
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.299484e-01	0.201
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	6.299484e-01	0.201
RNA Polymerase III Transcription Termination	R-HSA-73980	6.299484e-01	0.201
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.299484e-01	0.201
PKA activation in glucagon signalling	R-HSA-164378	6.299484e-01	0.201
Synaptic adhesion-like molecules	R-HSA-8849932	6.299484e-01	0.201
Regulation of gene expression in beta cells	R-HSA-210745	6.310330e-01	0.200
Platelet calcium homeostasis	R-HSA-418360	6.310330e-01	0.200
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.310330e-01	0.200
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	6.320739e-01	0.199
Generation of second messenger molecules	R-HSA-202433	6.350146e-01	0.197
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.350146e-01	0.197
Diseases of Immune System	R-HSA-5260271	6.350146e-01	0.197
Reverse Transcription of HIV RNA	R-HSA-162589	6.402229e-01	0.194
Minus-strand DNA synthesis	R-HSA-164516	6.402229e-01	0.194
phospho-PLA2 pathway	R-HSA-111995	6.402229e-01	0.194
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.402229e-01	0.194
Signaling by MRAS-complex mutants	R-HSA-9660537	6.402229e-01	0.194
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	6.402229e-01	0.194
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	6.402229e-01	0.194
Regulation by c-FLIP	R-HSA-3371378	6.402229e-01	0.194
Adrenoceptors	R-HSA-390696	6.402229e-01	0.194
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.402229e-01	0.194
Dimerization of procaspase-8	R-HSA-69416	6.402229e-01	0.194
TGFBR3 PTM regulation	R-HSA-9839383	6.402229e-01	0.194
Sodium/Proton exchangers	R-HSA-425986	6.402229e-01	0.194
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	6.402229e-01	0.194
Activated NTRK2 signals through FYN	R-HSA-9032500	6.402229e-01	0.194
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	6.497229e-01	0.187
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	6.497229e-01	0.187
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.528184e-01	0.185
E2F mediated regulation of DNA replication	R-HSA-113510	6.528184e-01	0.185
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.528184e-01	0.185
STING mediated induction of host immune responses	R-HSA-1834941	6.528184e-01	0.185
Uptake and actions of bacterial toxins	R-HSA-5339562	6.543620e-01	0.184
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	6.615924e-01	0.179
Signaling by FGFR1 in disease	R-HSA-5655302	6.668257e-01	0.176
Lipophagy	R-HSA-9613354	6.721631e-01	0.173
CASP8 activity is inhibited	R-HSA-5218900	6.721631e-01	0.173
p75NTR regulates axonogenesis	R-HSA-193697	6.721631e-01	0.173
GP1b-IX-V activation signalling	R-HSA-430116	6.721631e-01	0.173
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.721631e-01	0.173
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.721631e-01	0.173
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.721631e-01	0.173
Regulated proteolysis of p75NTR	R-HSA-193692	6.721631e-01	0.173
Interleukin-1 processing	R-HSA-448706	6.721631e-01	0.173
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.721631e-01	0.173
Regulation of PD-L1(CD274) translation	R-HSA-9909620	6.745462e-01	0.171
Formation of ATP by chemiosmotic coupling	R-HSA-163210	6.745462e-01	0.171
VxPx cargo-targeting to cilium	R-HSA-5620916	6.745462e-01	0.171
Creatine metabolism	R-HSA-71288	6.745462e-01	0.171
SARS-CoV-2 Infection	R-HSA-9694516	6.769068e-01	0.169
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.785122e-01	0.168
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.820005e-01	0.166
Signaling by FGFR	R-HSA-190236	6.820144e-01	0.166
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.820152e-01	0.166
Lagging Strand Synthesis	R-HSA-69186	6.951545e-01	0.158
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	6.951545e-01	0.158
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	6.951545e-01	0.158
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	6.951545e-01	0.158
SLC-mediated transport of amino acids	R-HSA-9958863	6.957325e-01	0.158
FCGR3A-mediated phagocytosis	R-HSA-9664422	6.977816e-01	0.156
Parasite infection	R-HSA-9664407	6.977816e-01	0.156
Leishmania phagocytosis	R-HSA-9664417	6.977816e-01	0.156
Developmental Cell Lineages	R-HSA-9734767	7.008320e-01	0.154
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.012694e-01	0.154
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.012694e-01	0.154
Receptor Mediated Mitophagy	R-HSA-8934903	7.012694e-01	0.154
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	7.012694e-01	0.154
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.012694e-01	0.154
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.012694e-01	0.154
PAOs oxidise polyamines to amines	R-HSA-141334	7.012694e-01	0.154
Interleukin-27 signaling	R-HSA-9020956	7.012694e-01	0.154
Maturation of spike protein	R-HSA-9683686	7.012694e-01	0.154
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.016803e-01	0.154
Signaling by FGFR1	R-HSA-5654736	7.081408e-01	0.150
Mitochondrial calcium ion transport	R-HSA-8949215	7.146706e-01	0.146
Serine metabolism	R-HSA-977347	7.146706e-01	0.146
Resolution of D-Loop Structures	R-HSA-5693537	7.176362e-01	0.144
Effects of PIP2 hydrolysis	R-HSA-114508	7.176362e-01	0.144
Glucagon signaling in metabolic regulation	R-HSA-163359	7.176362e-01	0.144
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.176362e-01	0.144
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	7.190890e-01	0.143
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.245734e-01	0.140
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.245734e-01	0.140
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.277931e-01	0.138
Ionotropic activity of kainate receptors	R-HSA-451306	7.277931e-01	0.138
vRNP Assembly	R-HSA-192905	7.277931e-01	0.138
Propionyl-CoA catabolism	R-HSA-71032	7.277931e-01	0.138
RHOBTB3 ATPase cycle	R-HSA-9706019	7.277931e-01	0.138
Synthesis of PI	R-HSA-1483226	7.277931e-01	0.138
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	7.277931e-01	0.138
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.277931e-01	0.138
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.277931e-01	0.138
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	7.277931e-01	0.138
Suppression of apoptosis	R-HSA-9635465	7.277931e-01	0.138
Transport of RCbl within the body	R-HSA-9758890	7.277931e-01	0.138
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.277931e-01	0.138
Dissolution of Fibrin Clot	R-HSA-75205	7.277931e-01	0.138
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	7.296608e-01	0.137
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.296608e-01	0.137
Gap junction assembly	R-HSA-190861	7.329214e-01	0.135
NPAS4 regulates expression of target genes	R-HSA-9768919	7.329214e-01	0.135
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.331261e-01	0.135
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.331261e-01	0.135
Cellular hexose transport	R-HSA-189200	7.331261e-01	0.135
LDL clearance	R-HSA-8964038	7.331261e-01	0.135
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	7.377834e-01	0.132
FCERI mediated NF-kB activation	R-HSA-2871837	7.377859e-01	0.132
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.428053e-01	0.129
Extension of Telomeres	R-HSA-180786	7.444363e-01	0.128
Amino acid transport across the plasma membrane	R-HSA-352230	7.444363e-01	0.128
RSV-host interactions	R-HSA-9833110	7.485212e-01	0.126
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.505085e-01	0.125
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.505553e-01	0.125
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.505553e-01	0.125
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.519633e-01	0.124
ERKs are inactivated	R-HSA-202670	7.519633e-01	0.124
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.519633e-01	0.124
Reduction of cytosolic Ca++ levels	R-HSA-418359	7.519633e-01	0.124
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.519633e-01	0.124
Sodium/Calcium exchangers	R-HSA-425561	7.519633e-01	0.124
Activation of RAC1	R-HSA-428540	7.519633e-01	0.124
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	7.519633e-01	0.124
tRNA Aminoacylation	R-HSA-379724	7.557659e-01	0.122
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.557659e-01	0.122
RUNX2 regulates bone development	R-HSA-8941326	7.615231e-01	0.118
GPVI-mediated activation cascade	R-HSA-114604	7.615231e-01	0.118
Glycosphingolipid transport	R-HSA-9845576	7.615231e-01	0.118
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	7.615231e-01	0.118
Triglyceride catabolism	R-HSA-163560	7.615231e-01	0.118
RET signaling	R-HSA-8853659	7.615231e-01	0.118
Intraflagellar transport	R-HSA-5620924	7.627540e-01	0.118
Gluconeogenesis	R-HSA-70263	7.627540e-01	0.118
Formation of paraxial mesoderm	R-HSA-9793380	7.667150e-01	0.115
Complex III assembly	R-HSA-9865881	7.669950e-01	0.115
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.669950e-01	0.115
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.669950e-01	0.115
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.669950e-01	0.115
Plasma lipoprotein assembly	R-HSA-8963898	7.669950e-01	0.115
Signaling by FGFR in disease	R-HSA-1226099	7.719145e-01	0.112
Signaling by NTRK1 (TRKA)	R-HSA-187037	7.731584e-01	0.112
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	7.739886e-01	0.111
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	7.739886e-01	0.111
GRB2 events in EGFR signaling	R-HSA-179812	7.739886e-01	0.111
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.739886e-01	0.111
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.739886e-01	0.111
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.739886e-01	0.111
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.739886e-01	0.111
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.739886e-01	0.111
Regulation of IFNG signaling	R-HSA-877312	7.739886e-01	0.111
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.739886e-01	0.111
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	7.739886e-01	0.111
Signaling by LTK	R-HSA-9842663	7.739886e-01	0.111
Interleukin-35 Signalling	R-HSA-8984722	7.739886e-01	0.111
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.739886e-01	0.111
Gastrulation	R-HSA-9758941	7.741781e-01	0.111
NCAM signaling for neurite out-growth	R-HSA-375165	7.772875e-01	0.109
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.809306e-01	0.107
Activation of G protein gated Potassium channels	R-HSA-1296041	7.824835e-01	0.107
G protein gated Potassium channels	R-HSA-1296059	7.824835e-01	0.107
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.824835e-01	0.107
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.824835e-01	0.107
Pyruvate metabolism	R-HSA-70268	7.865185e-01	0.104
MET promotes cell motility	R-HSA-8875878	7.875889e-01	0.104
Immune System	R-HSA-168256	7.925366e-01	0.101
Processing of SMDT1	R-HSA-8949664	7.940594e-01	0.100
Frs2-mediated activation	R-HSA-170968	7.940594e-01	0.100
CD28 dependent Vav1 pathway	R-HSA-389359	7.940594e-01	0.100
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.940594e-01	0.100
Platelet Adhesion to exposed collagen	R-HSA-75892	7.940594e-01	0.100
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.940594e-01	0.100
Interconversion of polyamines	R-HSA-351200	7.940594e-01	0.100
Maturation of nucleoprotein	R-HSA-9683610	7.940594e-01	0.100
The phototransduction cascade	R-HSA-2514856	7.966832e-01	0.099
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.970599e-01	0.099
Urea cycle	R-HSA-70635	7.970599e-01	0.099
Sphingolipid catabolism	R-HSA-9845614	7.970599e-01	0.099
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.070853e-01	0.093
Ion channel transport	R-HSA-983712	8.072425e-01	0.093
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	8.074152e-01	0.093
Integrin cell surface interactions	R-HSA-216083	8.085421e-01	0.092
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.107641e-01	0.091
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.107641e-01	0.091
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.107641e-01	0.091
Nuclear signaling by ERBB4	R-HSA-1251985	8.112452e-01	0.091
Inositol phosphate metabolism	R-HSA-1483249	8.119688e-01	0.090
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.123488e-01	0.090
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.123488e-01	0.090
Hydrolysis of LPC	R-HSA-1483115	8.123488e-01	0.090
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.123488e-01	0.090
Malate-aspartate shuttle	R-HSA-9856872	8.123488e-01	0.090
Acyl chain remodeling of CL	R-HSA-1482798	8.123488e-01	0.090
Transport to the Golgi and subsequent modification	R-HSA-948021	8.132168e-01	0.090
Maturation of spike protein	R-HSA-9694548	8.222133e-01	0.085
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.222133e-01	0.085
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.236360e-01	0.084
Telomere Extension By Telomerase	R-HSA-171319	8.236360e-01	0.084
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.236360e-01	0.084
Erythropoietin activates RAS	R-HSA-9027284	8.290149e-01	0.081
SHC1 events in EGFR signaling	R-HSA-180336	8.290149e-01	0.081
G beta:gamma signalling through BTK	R-HSA-8964315	8.290149e-01	0.081
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.290149e-01	0.081
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.290149e-01	0.081
Biotin transport and metabolism	R-HSA-196780	8.290149e-01	0.081
Other semaphorin interactions	R-HSA-416700	8.290149e-01	0.081
Transport and metabolism of PAPS	R-HSA-174362	8.290149e-01	0.081
DNA Damage Reversal	R-HSA-73942	8.290149e-01	0.081
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.326328e-01	0.080
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.326328e-01	0.080
Glucagon-type ligand receptors	R-HSA-420092	8.357153e-01	0.078
Signaling by NTRKs	R-HSA-166520	8.430014e-01	0.074
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.442018e-01	0.074
Defective GALNT3 causes HFTC	R-HSA-5083625	8.442018e-01	0.074
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.442018e-01	0.074
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.442018e-01	0.074
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.442018e-01	0.074
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	8.442018e-01	0.074
Attachment and Entry	R-HSA-9678110	8.442018e-01	0.074
Virus Assembly and Release	R-HSA-168268	8.442018e-01	0.074
DAP12 signaling	R-HSA-2424491	8.470412e-01	0.072
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.470412e-01	0.072
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.470412e-01	0.072
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.470412e-01	0.072
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.470412e-01	0.072
Cytoprotection by HMOX1	R-HSA-9707564	8.476646e-01	0.072
Parasitic Infection Pathways	R-HSA-9824443	8.525449e-01	0.069
Leishmania infection	R-HSA-9658195	8.525449e-01	0.069
Rab regulation of trafficking	R-HSA-9007101	8.568604e-01	0.067
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.576523e-01	0.067
Molecules associated with elastic fibres	R-HSA-2129379	8.576523e-01	0.067
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.580406e-01	0.066
G beta:gamma signalling through CDC42	R-HSA-8964616	8.580406e-01	0.066
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.580406e-01	0.066
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	8.580406e-01	0.066
Passive transport by Aquaporins	R-HSA-432047	8.580406e-01	0.066
Synthesis of PG	R-HSA-1483148	8.580406e-01	0.066
Galactose catabolism	R-HSA-70370	8.580406e-01	0.066
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.669094e-01	0.062
Stimuli-sensing channels	R-HSA-2672351	8.670729e-01	0.062
Inwardly rectifying K+ channels	R-HSA-1296065	8.675860e-01	0.062
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.675860e-01	0.062
Diseases of carbohydrate metabolism	R-HSA-5663084	8.703944e-01	0.060
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.706509e-01	0.060
PI3K events in ERBB2 signaling	R-HSA-1963642	8.706509e-01	0.060
Regulation of NPAS4 gene expression	R-HSA-9768759	8.706509e-01	0.060
Choline catabolism	R-HSA-6798163	8.706509e-01	0.060
Uptake and function of anthrax toxins	R-HSA-5210891	8.706509e-01	0.060
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.749776e-01	0.058
Transmission across Chemical Synapses	R-HSA-112315	8.750603e-01	0.058
SLC transporter disorders	R-HSA-5619102	8.755532e-01	0.058
G-protein beta:gamma signalling	R-HSA-397795	8.768790e-01	0.057
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	8.768790e-01	0.057
Cardiogenesis	R-HSA-9733709	8.768790e-01	0.057
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.771700e-01	0.057
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.771700e-01	0.057
Regulation of insulin secretion	R-HSA-422356	8.784625e-01	0.056
G beta:gamma signalling through PLC beta	R-HSA-418217	8.821417e-01	0.054
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.821417e-01	0.054
Presynaptic function of Kainate receptors	R-HSA-500657	8.821417e-01	0.054
Apoptotic factor-mediated response	R-HSA-111471	8.821417e-01	0.054
Aquaporin-mediated transport	R-HSA-445717	8.823502e-01	0.054
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	8.847000e-01	0.053
Acyl chain remodelling of PC	R-HSA-1482788	8.855667e-01	0.053
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.855667e-01	0.053
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.855667e-01	0.053
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.855667e-01	0.053
Mitochondrial protein import	R-HSA-1268020	8.888896e-01	0.051
Infectious disease	R-HSA-5663205	8.899176e-01	0.051
GPER1 signaling	R-HSA-9634597	8.918153e-01	0.050
Impaired BRCA2 binding to PALB2	R-HSA-9709603	8.926123e-01	0.049
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.926123e-01	0.049
Germ layer formation at gastrulation	R-HSA-9754189	8.926123e-01	0.049
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	8.926123e-01	0.049
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	8.926123e-01	0.049
Other interleukin signaling	R-HSA-449836	8.926123e-01	0.049
O2/CO2 exchange in erythrocytes	R-HSA-1480926	8.926123e-01	0.049
Specification of the neural plate border	R-HSA-9834899	8.926123e-01	0.049
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.926123e-01	0.049
Amine Oxidase reactions	R-HSA-140179	8.926123e-01	0.049
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	8.926123e-01	0.049
Maturation of nucleoprotein	R-HSA-9694631	8.926123e-01	0.049
Signal amplification	R-HSA-392518	8.936832e-01	0.049
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.936832e-01	0.049
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.936832e-01	0.049
Interferon gamma signaling	R-HSA-877300	8.948158e-01	0.048
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.951088e-01	0.048
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	9.012615e-01	0.045
Acyl chain remodelling of PE	R-HSA-1482839	9.012615e-01	0.045
Signalling to ERKs	R-HSA-187687	9.012615e-01	0.045
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.012615e-01	0.045
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	9.021533e-01	0.045
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	9.021533e-01	0.045
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	9.021533e-01	0.045
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	9.021533e-01	0.045
Acyl chain remodelling of PI	R-HSA-1482922	9.021533e-01	0.045
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.021533e-01	0.045
Pregnenolone biosynthesis	R-HSA-196108	9.021533e-01	0.045
Protein hydroxylation	R-HSA-9629569	9.021533e-01	0.045
Azathioprine ADME	R-HSA-9748787	9.048747e-01	0.043
FGFR2 mutant receptor activation	R-HSA-1839126	9.083331e-01	0.042
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.108471e-01	0.041
G-protein activation	R-HSA-202040	9.108471e-01	0.041
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.108471e-01	0.041
ERK/MAPK targets	R-HSA-198753	9.108471e-01	0.041
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.108471e-01	0.041
Zygotic genome activation (ZGA)	R-HSA-9819196	9.108471e-01	0.041
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.108471e-01	0.041
Acyl chain remodelling of PG	R-HSA-1482925	9.108471e-01	0.041
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.187690e-01	0.037
Attachment and Entry	R-HSA-9694614	9.187690e-01	0.037
Mitochondrial protein degradation	R-HSA-9837999	9.196606e-01	0.036
Platelet homeostasis	R-HSA-418346	9.205892e-01	0.036
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	9.210754e-01	0.036
Elastic fibre formation	R-HSA-1566948	9.210754e-01	0.036
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.210754e-01	0.036
Post-translational protein modification	R-HSA-597592	9.212418e-01	0.036
Amino acids regulate mTORC1	R-HSA-9639288	9.218006e-01	0.035
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.259873e-01	0.033
Signaling by KIT in disease	R-HSA-9669938	9.259873e-01	0.033
Neurotoxicity of clostridium toxins	R-HSA-168799	9.259873e-01	0.033
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.259873e-01	0.033
RAF-independent MAPK1/3 activation	R-HSA-112409	9.259873e-01	0.033
G alpha (z) signalling events	R-HSA-418597	9.315038e-01	0.031
Termination of O-glycan biosynthesis	R-HSA-977068	9.325646e-01	0.030
Mitochondrial mRNA modification	R-HSA-9937008	9.325646e-01	0.030
ABC transporters in lipid homeostasis	R-HSA-1369062	9.325646e-01	0.030
Growth hormone receptor signaling	R-HSA-982772	9.325646e-01	0.030
tRNA processing	R-HSA-72306	9.344323e-01	0.029
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.385578e-01	0.028
Thromboxane signalling through TP receptor	R-HSA-428930	9.385578e-01	0.028
Mitochondrial RNA degradation	R-HSA-9836573	9.385578e-01	0.028
TNFs bind their physiological receptors	R-HSA-5669034	9.385578e-01	0.028
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.386078e-01	0.028
Scavenging by Class A Receptors	R-HSA-3000480	9.417169e-01	0.026
Intra-Golgi traffic	R-HSA-6811438	9.417169e-01	0.026
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.417169e-01	0.026
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.439947e-01	0.025
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	9.440186e-01	0.025
Hyaluronan degradation	R-HSA-2160916	9.440186e-01	0.025
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.440186e-01	0.025
Laminin interactions	R-HSA-3000157	9.440186e-01	0.025
Integration of energy metabolism	R-HSA-163685	9.449854e-01	0.025
GABA B receptor activation	R-HSA-977444	9.460111e-01	0.024
Activation of GABAB receptors	R-HSA-991365	9.460111e-01	0.024
Regulation of beta-cell development	R-HSA-186712	9.476646e-01	0.023
Triglyceride metabolism	R-HSA-8979227	9.476646e-01	0.023
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.476646e-01	0.023
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.489697e-01	0.023
MET activates PTK2 signaling	R-HSA-8874081	9.489944e-01	0.023
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.489944e-01	0.023
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.489944e-01	0.023
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.489944e-01	0.023
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.489944e-01	0.023
Selenoamino acid metabolism	R-HSA-2408522	9.496552e-01	0.022
Neurotransmitter release cycle	R-HSA-112310	9.518211e-01	0.021
Extracellular matrix organization	R-HSA-1474244	9.521859e-01	0.021
Insulin processing	R-HSA-264876	9.535282e-01	0.021
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.535282e-01	0.021
Maturation of hRSV A proteins	R-HSA-9828806	9.535282e-01	0.021
DAP12 interactions	R-HSA-2172127	9.537117e-01	0.021
Surfactant metabolism	R-HSA-5683826	9.537117e-01	0.021
Amine ligand-binding receptors	R-HSA-375280	9.537117e-01	0.021
Neuronal System	R-HSA-112316	9.548028e-01	0.020
Signaling by PDGF	R-HSA-186797	9.573736e-01	0.019
Insulin receptor recycling	R-HSA-77387	9.576593e-01	0.019
Pyroptosis	R-HSA-5620971	9.576593e-01	0.019
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.585190e-01	0.018
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.602937e-01	0.018
Diseases of DNA repair	R-HSA-9675135	9.603551e-01	0.018
Neddylation	R-HSA-8951664	9.606109e-01	0.017
Signaling by Erythropoietin	R-HSA-9006335	9.614233e-01	0.017
Impaired BRCA2 binding to RAD51	R-HSA-9709570	9.614233e-01	0.017
Thyroxine biosynthesis	R-HSA-209968	9.614233e-01	0.017
Cardiac conduction	R-HSA-5576891	9.624946e-01	0.017
Collagen formation	R-HSA-1474290	9.640825e-01	0.016
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.648529e-01	0.016
Neurotransmitter clearance	R-HSA-112311	9.648529e-01	0.016
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.677101e-01	0.014
Downstream signal transduction	R-HSA-186763	9.679778e-01	0.014
Chemokine receptors bind chemokines	R-HSA-380108	9.686331e-01	0.014
Signaling by FGFR2 in disease	R-HSA-5655253	9.710019e-01	0.013
Formation of the cornified envelope	R-HSA-6809371	9.717440e-01	0.012
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.719429e-01	0.012
Complex IV assembly	R-HSA-9864848	9.731977e-01	0.012
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.734193e-01	0.012
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.746887e-01	0.011
Glutamate and glutamine metabolism	R-HSA-8964539	9.757830e-01	0.011
Miscellaneous transport and binding events	R-HSA-5223345	9.757830e-01	0.011
Heme degradation	R-HSA-189483	9.757830e-01	0.011
Metabolism of proteins	R-HSA-392499	9.769310e-01	0.010
ECM proteoglycans	R-HSA-3000178	9.773187e-01	0.010
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	9.779366e-01	0.010
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	9.779366e-01	0.010
Hyaluronan metabolism	R-HSA-2142845	9.779366e-01	0.010
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.779366e-01	0.010
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.779366e-01	0.010
Interferon alpha/beta signaling	R-HSA-909733	9.798174e-01	0.009
Transferrin endocytosis and recycling	R-HSA-917977	9.798989e-01	0.009
NCAM1 interactions	R-HSA-419037	9.833156e-01	0.007
Lysine catabolism	R-HSA-71064	9.833156e-01	0.007
Collagen chain trimerization	R-HSA-8948216	9.833156e-01	0.007
Metabolism of folate and pterines	R-HSA-196757	9.833156e-01	0.007
Dectin-2 family	R-HSA-5621480	9.833603e-01	0.007
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.846413e-01	0.007
tRNA processing in the mitochondrion	R-HSA-6785470	9.847997e-01	0.007
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.858591e-01	0.006
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.860739e-01	0.006
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.861519e-01	0.006
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.861519e-01	0.006
GABA receptor activation	R-HSA-977443	9.869218e-01	0.006
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.869837e-01	0.006
rRNA processing in the mitochondrion	R-HSA-8868766	9.873838e-01	0.006
Tryptophan catabolism	R-HSA-71240	9.873838e-01	0.006
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.873838e-01	0.006
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.874630e-01	0.005
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.885063e-01	0.005
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.889975e-01	0.005
Heme biosynthesis	R-HSA-189451	9.895289e-01	0.005
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.901711e-01	0.004
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.904606e-01	0.004
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.909427e-01	0.004
Innate Immune System	R-HSA-168249	9.915223e-01	0.004
Peptide ligand-binding receptors	R-HSA-375276	9.916741e-01	0.004
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.920828e-01	0.003
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.927874e-01	0.003
Disease	R-HSA-1643685	9.928745e-01	0.003
Synthesis of PC	R-HSA-1483191	9.940141e-01	0.003
COPII-mediated vesicle transport	R-HSA-204005	9.942001e-01	0.003
Metabolism of cofactors	R-HSA-8978934	9.946572e-01	0.002
Metabolism of porphyrins	R-HSA-189445	9.946572e-01	0.002
Class B/2 (Secretin family receptors)	R-HSA-373080	9.947762e-01	0.002
Purine catabolism	R-HSA-74259	9.950790e-01	0.002
PI3K Cascade	R-HSA-109704	9.954746e-01	0.002
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.954746e-01	0.002
Asparagine N-linked glycosylation	R-HSA-446203	9.957457e-01	0.002
ROS and RNS production in phagocytes	R-HSA-1222556	9.958267e-01	0.002
Cytosolic sulfonation of small molecules	R-HSA-156584	9.958774e-01	0.002
SLC-mediated transmembrane transport	R-HSA-425407	9.960813e-01	0.002
Nucleotide biosynthesis	R-HSA-8956320	9.965789e-01	0.001
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.967438e-01	0.001
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.969203e-01	0.001
Leishmania parasite growth and survival	R-HSA-9664433	9.969203e-01	0.001
Nuclear Receptor transcription pathway	R-HSA-383280	9.970030e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.970030e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.970030e-01	0.001
G alpha (q) signalling events	R-HSA-416476	9.970697e-01	0.001
Metabolism of amine-derived hormones	R-HSA-209776	9.974138e-01	0.001
IRS-mediated signalling	R-HSA-112399	9.976441e-01	0.001
Synthesis of PA	R-HSA-1483166	9.976441e-01	0.001
Synthesis of bile acids and bile salts	R-HSA-192105	9.977401e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.979003e-01	0.001
IRS-related events triggered by IGF1R	R-HSA-2428928	9.983779e-01	0.001
Collagen degradation	R-HSA-1442490	9.983779e-01	0.001
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.985224e-01	0.001
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.985862e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.986540e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.987357e-01	0.001
PPARA activates gene expression	R-HSA-1989781	9.987403e-01	0.001
CD22 mediated BCR regulation	R-HSA-5690714	9.987739e-01	0.001
IGF1R signaling cascade	R-HSA-2428924	9.987739e-01	0.001
Insulin receptor signalling cascade	R-HSA-74751	9.987739e-01	0.001
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.988832e-01	0.000
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.988982e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.989069e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.990733e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.990733e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.991113e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.991559e-01	0.000
Signaling by Insulin receptor	R-HSA-74752	9.992162e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.992406e-01	0.000
FCGR activation	R-HSA-2029481	9.992797e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.992997e-01	0.000
Transport of small molecules	R-HSA-382551	9.993418e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.993621e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.993920e-01	0.000
Aspirin ADME	R-HSA-9749641	9.994707e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.994870e-01	0.000
Potassium Channels	R-HSA-1296071	9.994870e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.994885e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.995672e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.996374e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.996682e-01	0.000
PI Metabolism	R-HSA-1483255	9.996923e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.997175e-01	0.000
Respiratory electron transport	R-HSA-611105	9.997564e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.998106e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.998270e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.998450e-01	0.000
Visual phototransduction	R-HSA-2187338	9.998466e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998782e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.998813e-01	0.000
Keratinization	R-HSA-6805567	9.998853e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.998965e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999222e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999346e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999534e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999591e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999786e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999789e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999861e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999896e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999919e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999960e-01	0.000
Drug ADME	R-HSA-9748784	9.999973e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999978e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999982e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999988e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999992e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999994e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999994e-01	0.000
Infection with Enterobacteria	R-HSA-9640148	9.999998e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999998e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999999e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999999e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999999e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999999e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000