CDK9

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O00115	S70	Sugiyama	DNASE2 DNASE2A DNL2	QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00165	S153	Sugiyama	HAX1 HS1BP1	PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O00178	S12	Sugiyama	GTPBP1	_________MATERsRsAMDsPVPAsMFAPEPssPGAARAA
O00178	S6	Sugiyama	GTPBP1	_______________MATERsRsAMDsPVPAsMFAPEPssP
O00178	S8	Sugiyama	GTPBP1	_____________MATERsRsAMDsPVPAsMFAPEPssPGA
O00193	S17	Sugiyama	SMAP C11orf58	____MsAARESHPHGVKRsAsPDDDLGssNWEAADLGNEER
O00267	S666	EPSD\|PSP	SUPT5H SPT5 SPT5H	AGGSKPRDVtNFtVGGFAPMsPRIssPMHPSAGGQRGGFGs
O00267	S773	PSP	SUPT5H SPT5 SPT5H	VGsRRPGGMTsTYGRtPMYGsQtPMYGsGsRtPMYGsQtPL
O00267	S782	PSP	SUPT5H SPT5 SPT5H	TsTYGRtPMYGsQtPMYGsGsRtPMYGsQtPLQDGsRtPHy
O00267	T768	SIGNOR\|EPSD\|PSP	SUPT5H SPT5 SPT5H	QRLTTVGsRRPGGMTsTYGRtPMYGsQtPMYGsGsRtPMYG
O00267	T775	GPS6\|SIGNOR\|EPSD\|PSP	SUPT5H SPT5 SPT5H	sRRPGGMTsTYGRtPMYGsQtPMYGsGsRtPMYGsQtPLQD
O00267	T784	GPS6\|SIGNOR\|EPSD\|PSP	SUPT5H SPT5 SPT5H	TYGRtPMYGsQtPMYGsGsRtPMYGsQtPLQDGsRtPHyGs
O00267	T791	SIGNOR\|EPSD\|PSP	SUPT5H SPT5 SPT5H	YGsQtPMYGsGsRtPMYGsQtPLQDGsRtPHyGsQtPLHDG
O00267	T799	SIGNOR\|EPSD\|PSP	SUPT5H SPT5 SPT5H	GsGsRtPMYGsQtPLQDGsRtPHyGsQtPLHDGsRtPAQsG
O00267	T806	SIGNOR\|EPSD\|PSP	SUPT5H SPT5 SPT5H	MYGsQtPLQDGsRtPHyGsQtPLHDGsRtPAQsGAWDPNNP
O00267	T814	SIGNOR\|EPSD\|PSP	SUPT5H SPT5 SPT5H	QDGsRtPHyGsQtPLHDGsRtPAQsGAWDPNNPNtPsRAEE
O14545	S327	Sugiyama	TRAFD1 FLN29	DHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQQAAS
O14545	T323	Sugiyama	TRAFD1 FLN29	ELLIDHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQ
O14979	S241	Sugiyama	HNRNPDL HNRPDL JKTBP	KRAKALKGKEPPKKVFVGGLsPDtsEEQIKEYFGAFGEIEN
O15047	S470	Sugiyama	SETD1A KIAA0339 KMT2F SET1 SET1A	sPEREEVRtsPRPAsPARsGsPAPEttNESVPFAQHSSLDS
O15085	S1295	Sugiyama	ARHGEF11 KIAA0380	PEQEDMGLCSLEHLPPRtRNsGIWEsPELDRNLAEDASSTE
O43237	S194	Sugiyama	DYNC1LI2 DNCLI2 LIC2	ERKFVKDFQDyMEPEEGCQGsPQRRGPLtsGsDEENVALPL
O43765	S77	Sugiyama	SGTA SGT SGT1	TLPEIFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTE
O43765	S84	Sugiyama	SGTA SGT SGT1	AAATGKEMPQDLRsPARtPPsEEDsAEAERLKTEGNEQMKV
O43765	T81	Sugiyama	SGTA SGT SGT1	IFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTEGNEQ
O43852	S261	Sugiyama	CALU	RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852	T65	Sugiyama	CALU	FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60239	S375	Sugiyama	SH3BP5 SAB	LsEFGMMFPVLGPRsECsGAssPECEVERGDRAEGAENKTS
O60292	S158	Sugiyama	SIPA1L3 KIAA0545 SPAL3	FHRLSRRRsKDVEFQDGWPRsPGRAFLPLRHRsssEItLSE
O60563	S352	Sugiyama	CCNT1	KRWLSSQPsFKLEPTQGHRtsENLALtGVDHsLPQDGsNAF
O60563	S363	Sugiyama	CCNT1	LEPTQGHRtsENLALtGVDHsLPQDGsNAFISQKQNSKSVP
O60563	S369	Sugiyama	CCNT1	HRtsENLALtGVDHsLPQDGsNAFISQKQNSKSVPSAKVSL
O60563	S427	Sugiyama	CCNT1	LENMEANVKSQYAyAAQNLLsHHDsHsSVILKMPIEGsENP
O60563	S431	Sugiyama	CCNT1	EANVKSQYAyAAQNLLsHHDsHsSVILKMPIEGsENPERPF
O60563	S433	Sugiyama	CCNT1	NVKSQYAyAAQNLLsHHDsHsSVILKMPIEGsENPERPFLE
O60563	S444	Sugiyama	CCNT1	NLLsHHDsHsSVILKMPIEGsENPERPFLEKADKTALKMRI
O60563	S577	Sugiyama	CCNT1	KTYSLSssFsSSsSTRKRGPsEEtGGAVFDHPAKIAKSTKS
O60563	T216	Sugiyama	CCNT1	VACVCIHLACKWSNWEIPVStDGKHWWEYVDATVTLELLDE
O60563	T358	Sugiyama	CCNT1	QPsFKLEPTQGHRtsENLALtGVDHsLPQDGsNAFISQKQN
O60563	T580	Sugiyama	CCNT1	SLSssFsSSsSTRKRGPsEEtGGAVFDHPAKIAKSTKSSSL
O60563	Y420	Sugiyama	CCNT1	LAAQKRQLENMEANVKSQYAyAAQNLLsHHDsHsSVILKMP
O60583	T215	Sugiyama	CCNT2	IACVCIHLACKWSNWEIPVStDGKHWWEYVDPTVTLELLDE
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75131	S240	Sugiyama	CPNE3 CPN3 KIAA0636	DGSHDLIGTFQTTMTKLKEAsRssPVEFECINEKKRQKKKS
O75533	T223	Sugiyama	SF3B1 SAP155	tADQtPGAtPKKLssWDQAEtPGHtPsLRWDEtPGRAKGsE
O75533	T227	Sugiyama	SF3B1 SAP155	tPGAtPKKLssWDQAEtPGHtPsLRWDEtPGRAKGsEtPGA
O75533	T313	Sugiyama	SF3B1 SAP155	WDEtPKtERDtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsK
O75828	S56	Sugiyama	CBR3 SDR21C2	TARDVARGQAAVQQLQAEGLsPRFHQLDIDDLQsIRALRDF
O75909	S36	Sugiyama	CCNK CPR4	NLDHTKPCWYWDKKDLAHTPsQLEGLDPATEARYRREGARF
O76080	S61	Sugiyama	ZFAND5 ZA20D2 ZNF216	QQNsGRMsPMGtAsGsNsPtsDSASVQRADtsLNNCEGAAG
O94826	S91	Sugiyama	TOMM70 KIAA0719 TOM70 TOMM70A	RGDASGLKRNSERKtPEGRAsPAPGsGHPEGPGAHLDMNsL
O94842	S178	Sugiyama	TOX4 C14orf92 KIAA0737	GGGTILPPAQSPEDRLsttPsPtssLHEDGVEDFRRQLPSQ
O94979	S188	Sugiyama	SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334	PEDISCIAWNRQVQHILAsAsPsGRATVWDLRKNEPIIKVS
O94979	S799	Sugiyama	SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334	IMQLRDRLCRAQGEPVAGHEsPKIPyEKQQLPKGRPGPVAG
O95149	S350	Sugiyama	SNUPN RNUT1 SPN1	ENGHyELEHLstPKLKGssHsPDHPGCLMEN__________
O95155	S88	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	GASGVAHRsQssEGVssLsssPsNsLEtQsQsLsRsQsMDI
O95359	S2317	Sugiyama	TACC2	MPLRRPKMKKtPEKLDNtPAsPPRsPAEPNDIPIAKGTYTF
O95359	S2321	Sugiyama	TACC2	RPKMKKtPEKLDNtPAsPPRsPAEPNDIPIAKGTYTFDIDK
O96019	S195	PSP	ACTL6A BAF53 BAF53A INO80K	THTTAIPVHDGYVLQQGIVKsPLAGDFITMQCRELFQEMNI
O96019	S233	PSP	ACTL6A BAF53 BAF53A INO80K	MNIELVPPYMIASKEAVREGsPANWKRKEKLPQVTRSWHNY
O96019	S86	PSP	ACTL6A BAF53 BAF53A INO80K	PtyyIDtNALRVPRENMEAIsPLKNGMVEDWDSFQAILDHT
P00558	T168	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P02545	S390	Sugiyama	LMNA LMN1	DMEIHAYRKLLEGEEERLRLsPsPtsQRsRGRAssHssQtQ
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04637	S315	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	TP53 P53	PHHELPPGStKRALPNNTsssPQPKKKPLDGEyFTLQIRGR
P04637	S33	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	TP53 P53	PLsQEtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQW
P04637	S392	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	TP53 P53	KKGQstsRHKKLMFKtEGPDsD___________________
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187	S177	Sugiyama	ALPP PLAP	RAKKAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADVP
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05387	S17	Sugiyama	RPLP2 D11S2243E RPP2	____MRyVAsyLLAALGGNssPsAKDIKKILDsVGIEADDD
P06400	S795	EPSD\|PSP	RB1	RPPtLsPIPHIPRsPyKFPssPLRIPGGNIyIsPLKsPYKI
P06400	S807	EPSD\|PSP	RB1	RsPyKFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtP
P06400	S811	EPSD\|PSP	RB1	KFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtPRSRI
P06733	S263	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GMDVAASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsF
P06744	S455	Sugiyama	GPI	ALMRGKSTEEARKELQAAGKsPEDLERLLPHKVFEGNRPTN
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	T168	Sugiyama	PGK2 PGKB	EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07437	S168	Sugiyama	TUBB TUBB5 OK/SW-cl.56	GTLLISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLS
P07437	S172	Sugiyama	TUBB TUBB5 OK/SW-cl.56	ISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLSVHQL
P07437	T166	Sugiyama	TUBB TUBB5 OK/SW-cl.56	GMGTLLISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNAT
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814	S885	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	KEKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPEAKVLF
P07858	S216	Sugiyama	CTSB CPSB	PPCTGEGDTPKCSKICEPGysPtyKQDKHYGYNSYSVSNSE
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08865	T97	Sugiyama	RPSA LAMBR LAMR1	IssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQAAFR
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09923	S174	Sugiyama	ALPI	RAKQAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADMP
P09972	S132	Sugiyama	ALDOC ALDC	GVVPLAGtDGEtttQGLDGLsERCAQYKKDGADFAKWRCVL
P10275	S83	PSP	AR DHTR NR3C4	QQQQQQQQQQQQQQQQQQETsPRQQQQQQGEDGsPQAHRRG
P10412	S187	PSP	H1-4 H1F4 HIST1H1E	AKKAKsPKKAKAAKPKKAPKsPAKAKAVKPKAAKPKTAKPK
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142	T38	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142	T45	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625	S552	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	KEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEPV
P14866	S101	Sugiyama	HNRNPL HNRPL P/OKcl.14	GAAGGGGGGENyDDPHKtPAsPVVHIRGLIDGVVEADLVEA
P15559	S82	Sugiyama	NQO1 DIA4 NMOR1	DPANFQYPAESVLAYKEGHLsPDIVAEQKKLEAADLVIFQF
P16152	S56	Sugiyama	CBR1 CBR CRN SDR21C1	TARDVTRGQAAVQQLQAEGLsPRFHQLDIDDLQsIRALRDF
P17066	T40	Sugiyama	HSPA6 HSP70B'	VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18124	T17	Sugiyama	RPL7	____MEGVEEKKKEVPAVPEtLKKKRRNFAELKIKRLRKKF
P18669	S31	Sugiyama	PGAM1 PGAMA CDABP0006	HGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQALRDAGyE
P18754	S11	Sugiyama	RCC1 CHC1	__________MsPKRIAKRRsPPADAIPKsKKVKVsHRsHs
P19338	S563	Sugiyama	NCL	CNKREIEGRAIRLELQGPRGsPNARSQPSKTLFVKGLsEDt
P21333	S1084	Sugiyama	FLNA FLN FLN1	PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P22059	S190	Sugiyama	OSBP OSBP1	QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059	S193	Sugiyama	OSBP OSBP1	VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22234	S27	Sugiyama	PAICS ADE2 AIRC PAIS	LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626	S225	Sugiyama	HNRNPA2B1 HNRPA2B1	GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P22626	S259	Sugiyama	HNRNPA2B1 HNRPA2B1	GFGDGyNGyGGGPGGGNFGGsPGyGGGRGGYGGGGPGYGNQ
P22681	S900	Sugiyama	CBL CBL2 RNF55	IAQNNIEMAKNILREFVSIssPAHVAT______________
P23246	T687	Sugiyama	SFPQ PSF	FGQGGAGPVGGQGPRGMGPGtPAGyGRGREEYEGPNKKPRF
P24928	S1616	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	POLR2A POLR2	TSPAYEPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNY
P24928	S1619	EPSD\|PSP	POLR2A POLR2	AYEPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNYSPT
P24928	S1621	EPSD\|PSP	POLR2A POLR2	EPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNYSPTSP
P24928	S1623	SIGNOR	POLR2A POLR2	RSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNYSPTSPSY
P24928	S1644	SIGNOR	POLR2A POLR2	PTsPSYSPTSPNYSPTSPSYsPTsPSYsPTsPSYSPTSPSY
P24928	S1651	SIGNOR	POLR2A POLR2	PTSPNYSPTSPSYsPTsPSYsPTsPSYSPTSPSYsPTsPSY
P24928	S1665	SIGNOR	POLR2A POLR2	PTsPSYsPTsPSYSPTSPSYsPTsPSYsPTsPSYSPTSPSY
P24928	S1672	SIGNOR	POLR2A POLR2	PTsPSYSPTSPSYsPTsPSYsPTsPSYSPTSPSYSPTSPSY
P24928	S1693	SIGNOR	POLR2A POLR2	PTsPSYSPTSPSYSPTSPSYsPTsPSYSPTSPSYSPTSPSY
P24928	S1714	SIGNOR	POLR2A POLR2	PTsPSYSPTSPSYSPTSPSYsPTsPSYsPTsPSYSPTSPSY
P24928	S1721	SIGNOR	POLR2A POLR2	PTSPSYSPTSPSYsPTsPSYsPTsPSYSPTSPSYsPTsPSY
P24928	S1735	SIGNOR	POLR2A POLR2	PTsPSYsPTsPSYSPTSPSYsPTsPSYSPTSPNYSPTSPNY
P24928	S1763	SIGNOR	POLR2A POLR2	PTSPNYSPTSPNYTPTSPSYsPTsPSYSPTSPNYTPTSPNY
P24928	S1784	SIGNOR	POLR2A POLR2	PTsPSYSPTSPNYTPTSPNYsPTsPSYSPTSPSYSPTSPSY
P24928	S1861	SIGNOR	POLR2A POLR2	PtsPsysPssPEytPtsPKysPtsPKysPtsPKysPtsPty
P24928	S1868	SIGNOR	POLR2A POLR2	PssPEytPtsPKysPtsPKysPtsPKysPtsPtysPttPKy
P24928	S1875	SIGNOR	POLR2A POLR2	PtsPKysPtsPKysPtsPKysPtsPtysPttPKysPtsPty
P24928	S1878	SIGNOR	POLR2A POLR2	PKysPtsPKysPtsPKysPtsPtysPttPKysPtsPtysPt
P24928	S1882	SIGNOR	POLR2A POLR2	PtsPKysPtsPKysPtsPtysPttPKysPtsPtysPtsPVy
P24928	S1889	SIGNOR	POLR2A POLR2	PtsPKysPtsPtysPttPKysPtsPtysPtsPVytPtsPKy
P24928	S1896	SIGNOR	POLR2A POLR2	PtsPtysPttPKysPtsPtysPtsPVytPtsPKysPtsPty
P24928	S1910	SIGNOR	POLR2A POLR2	PtsPtysPtsPVytPtsPKysPtsPtysPtsPKysPtsPty
P24928	S1913	Sugiyama	POLR2A POLR2	PtysPtsPVytPtsPKysPtsPtysPtsPKysPtsPtysPt
P24928	S1917	SIGNOR	POLR2A POLR2	PtsPVytPtsPKysPtsPtysPtsPKysPtsPtysPtsPKG
P24928	S1924	SIGNOR	POLR2A POLR2	PtsPKysPtsPtysPtsPKysPtsPtysPtsPKGstYsPts
P24928	S1931	SIGNOR	POLR2A POLR2	PtsPtysPtsPKysPtsPtysPtsPKGstYsPtsPGYsPts
P24928	S1941	SIGNOR	POLR2A POLR2	PKysPtsPtysPtsPKGstYsPtsPGYsPtsPTYSLTsPAI
P24928	S1948	SIGNOR	POLR2A POLR2	PtysPtsPKGstYsPtsPGYsPtsPTYSLTsPAIsPDDsDE
P24928	T1525	PSP	POLR2A POLR2	SAPsPMGGIsPAMTPWNQGAtPAYGAWsPSVGSGMtPGAAG
P24928	T1540	PSP	POLR2A POLR2	WNQGAtPAYGAWsPSVGSGMtPGAAGFSPSAASDASGFSPG
P24928	T1618	EPSD\|PSP	POLR2A POLR2	PAYEPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNYSP
P24928	T1919	Sugiyama	POLR2A POLR2	sPVytPtsPKysPtsPtysPtsPKysPtsPtysPtsPKGst
P25054	S1042	Sugiyama	APC DP2.5	DtPINYSLKysDEQLNsGRQsPsQNERWARPKHIIEDEIKQ
P25786	S14	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	_______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P27824	S583	Sugiyama	CANX	VsQEEEDRKPKAEEDEILNRsPRNRKPRRE___________
P29401	S332	Sugiyama	TKT	GDKIATRKAYGQALAKLGHAsDRIIALDGDtKNstFsEIFK
P29692	S133	Sugiyama	EEF1D EF1D	NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692	T125	Sugiyama	EEF1D EF1D	IsKLEARLNVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKP
P29692	T147	Sugiyama	EEF1D EF1D	PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P29966	S26	Sugiyama	MARCKS MACS PRKCSL	SKTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAs
P29966	S27	Sugiyama	MARCKS MACS PRKCSL	KTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAsP
P31943	S104	Sugiyama	HNRNPH1 HNRPH HNRPH1	EVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P31943	T100	Sugiyama	HNRNPH1 HNRPH HNRPH1	HRyVEVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPF
P33316	S88	Sugiyama	DUT	RGASTVGAAGWKGELPKAGGsPAPGPEtPAIsPsKRARPAE
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931	T40	Sugiyama	HSPA1L	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931	T47	Sugiyama	HSPA1L	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P35251	S1088	Sugiyama	RFC1 RFC140	KEAHLtPYsLQAIKASRHstsPSLDsEyNEELNEDDsQsDE
P35269	T389	Sugiyama	GTF2F1 RAP74	PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P37231	S112	EPSD\|PSP	PPARG NR1C3	DYKYDLKLQEyQSAIKVEPAsPPYYSEKTQLYNKPHEEPSN
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37802	T190	Sugiyama	TAGLN2 KIAA0120 CDABP0035	GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41091	T109	Sugiyama	EIF2S3 EIF2G	YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P42898	T34	Sugiyama	MTHFR	CLEGSASSGSESSKDSSRCStPGLDPERHERLREKMRRRLE
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46783	T148	Sugiyama	RPS10	RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P46937	T119	Sugiyama	YAP1 YAP65	PEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQLGAVsP
P48741	T40	Sugiyama	HSPA7 HSP70B	VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P49023	S303	Sugiyama	PXN	QRADGERCWAAGWPRDGGRssPGGQDEGGFMAQGKtGsssP
P49736	S27	Sugiyama	MCM2 BM28 CCNL1 CDCL1 KIAA0030	sFtMAssPAQRRRGNDPLtssPGRssRRtDALtssPGRDLP
P50750	S347	GPS6\|EPSD\|PSP	CDK9 CDC2L4 TAK	MLSTHLTSMFEyLAPPRRKGsQItQQstNQsRNPAttNQtE
P50750	S353	GPS6\|EPSD\|PSP	CDK9 CDC2L4 TAK	TSMFEyLAPPRRKGsQItQQstNQsRNPAttNQtEFERVF_
P50750	S357	GPS6\|EPSD	CDK9 CDC2L4 TAK	EyLAPPRRKGsQItQQstNQsRNPAttNQtEFERVF_____
P50750	S7	Sugiyama	CDK9 CDC2L4 TAK	______________MAKQYDsVECPFCDEVSKyEKLAKIGQ
P50750	T186	GPS6\|EPSD\|PSP	CDK9 CDC2L4 TAK	ADFGLARAFsLAKNSQPNRytNRVVTLWYRPPELLLGERDY
P50750	T29	Sugiyama	CDK9 CDC2L4 TAK	ECPFCDEVSKyEKLAKIGQGtFGEVFKARHRKTGQKVALKK
P50750	T350	GPS6\|EPSD	CDK9 CDC2L4 TAK	THLTSMFEyLAPPRRKGsQItQQstNQsRNPAttNQtEFER
P50750	T354	GPS6\|EPSD\|PSP	CDK9 CDC2L4 TAK	SMFEyLAPPRRKGsQItQQstNQsRNPAttNQtEFERVF__
P50750	T362	GPS6\|EPSD\|PSP\|Sugiyama	CDK9 CDC2L4 TAK	PRRKGsQItQQstNQsRNPAttNQtEFERVF__________
P50750	T363	GPS6\|EPSD\|PSP\|Sugiyama	CDK9 CDC2L4 TAK	RRKGsQItQQstNQsRNPAttNQtEFERVF___________
P50750	T366	Sugiyama	CDK9 CDC2L4 TAK	GsQItQQstNQsRNPAttNQtEFERVF______________
P51858	S165	Sugiyama	HDGF HMG1L2	AKEKNEKGALKRRAGDLLEDsPKRPKEAENPEGEEKEAAtL
P51991	S358	Sugiyama	HNRNPA3 HNRPA3	QQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF
P52948	S839	Sugiyama	NUP98 ADAR2	AEVtLDGVWPTDKTSRCLIKsPDRLADINyEGRLEAVSRKQ
P54646	S176	Sugiyama	PRKAA2 AMPK AMPK2	ADFGLSNMMsDGEFLRtsCGsPNyAAPEVISGRLYAGPEVD
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652	T39	Sugiyama	HSPA2	VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652	T46	Sugiyama	HSPA2	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P55081	T267	Sugiyama	MFAP1	ETKKELEENKRsLAALDALNtDDENDEEEyEAWKVRELKRI
P55795	S104	Sugiyama	HNRNPH2 FTP3 HNRPH2	EVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P55795	T100	Sugiyama	HNRNPH2 FTP3 HNRPH2	HRyVEVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPF
P55809	S509	Sugiyama	OXCT1 OXCT SCOT	LWEGLTVDDVQKSTGCDFAVsPKLMPMQQIAN_________
P60709	S300	Sugiyama	ACTB	NSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItAL
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61916	S40	Sugiyama	NPC2 HE1	EPVQFKDCGsVDGVIKEVNVsPCPtQPCQLSKGQSYSVNVT
P61978	S284	Sugiyama	HNRNPK HNRPK	MPPGRGGRPMPPSRRDyDDMsPRRGPPPPPPGRGGRGGsRA
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62714	S212	Sugiyama	PPP2CB	EGPMCDLLWSDPDDRGGWGIsPRGAGYTFGQDISETFNHAN
P62899	T119	Sugiyama	RPL31	PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62942	S9	Sugiyama	FKBP1A FKBP1 FKBP12	____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63261	S300	Sugiyama	ACTG1 ACTG	NSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItAL
P67775	S212	Sugiyama	PPP2CA	EGPMCDLLWSDPDDRGGWGIsPRGAGYTFGQDISETFNHAN
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P84022	S208	SIGNOR\|EPSD\|PSP	SMAD3 MADH3	DGETSDHQMNHSMDAGsPNLsPNPMsPAHNNLDLQPVTYCE
P84022	S213	SIGNOR\|EPSD\|PSP	SMAD3 MADH3	DHQMNHSMDAGsPNLsPNPMsPAHNNLDLQPVTYCEPAFWC
P84022	T179	SIGNOR\|EPSD\|PSP	SMAD3 MADH3	SIPENTNFPAGIEPQSNIPEtPPPGYLSEDGETSDHQMNHS
P85037	S420	Sugiyama	FOXK1 MNF	RGVSCFRtPFGPLssRsAPAsPtHPGLMsPRsGGLQtPECL
P85037	S428	Sugiyama	FOXK1 MNF	PFGPLssRsAPAsPtHPGLMsPRsGGLQtPECLsREGsPIP
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00987	S166	PSP	MDM2	KPSSSHLVSRPstSSRRRAIsEtEENsDELsGERQRKRHKs
Q01082	S2138	Sugiyama	SPTBN1 SPTB2	QWDtsKGEQVsQNGLPAEQGsPRMAETVDTsEMVNGAtEQR
Q01082	S2197	Sugiyama	SPTBN1 SPTB2	KTALPAQsAAtLPARtQEtPsAQMEGFLNRKHEWEAHNKKA
Q02539	S183	EPSD\|PSP	H1-1 H1F1 HIST1H1A	RKSSKNPKKPKTVKPKKVAKsPAKAKAVKPKAAKARVTKPK
Q02543	T24	Sugiyama	RPL18A	SGTLREYKVVGRCLPTPKCHtPPLYRMRIFAPNHVVAKSRF
Q06830	T166	Sugiyama	PRDX1 PAGA PAGB TDPX2	DLPVGRsVDEtLRLVQAFQFtDKHGEVCPAGWKPGsDtIKP
Q07960	S51	Sugiyama	ARHGAP1 CDC42GAP RHOGAP1	KNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARHQ
Q08AD1	S1319	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	NEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWENAstts
Q12931	S568	Sugiyama	TRAP1 HSP75 HSPC5	ISVETDIVVDHYKEEKFEDRsPAAECLSEKETEELMAWMRN
Q13033	S229	Sugiyama	STRN3 GS2NA SG2NA	SEPNGsVETKNLEQILNGGEsPKQKGQEIKRSSGDVLETFN
Q13098	S468	Sugiyama	GPS1 COPS1 CSN1	RRAKAMMLRAAVLRNQIHVKsPPREGsQGELtPANsQsRMs
Q13112	S410	Sugiyama	CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7	LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13131	S187	Sugiyama	PRKAA1 AMPK1	ADFGLsNMMsDGEFLRtsCGsPNyAAPEVISGRLYAGPEVD
Q13200	S16	Sugiyama	PSMD2 TRAP2	_____MEEGGRDKAPVQPQQsPAAAPGGtDEKPsGKERRDA
Q13242	S211	Sugiyama	SRSF9 SFRS9 SRP30C	GYsRsRSGsRGRDsPyQsRGsPHyFsPFRPy__________
Q13242	S216	Sugiyama	SRSF9 SFRS9 SRP30C	RSGsRGRDsPyQsRGsPHyFsPFRPy_______________
Q13242	Y214	Sugiyama	SRSF9 SFRS9 SRP30C	RsRSGsRGRDsPyQsRGsPHyFsPFRPy_____________
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283	S231	Sugiyama	G3BP1 G3BP	QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13442	S63	Sugiyama	PDAP1 HASPP28	GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13509	S168	Sugiyama	TUBB3 TUBB4	GTLLISKVREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLS
Q13509	S172	Sugiyama	TUBB3 TUBB4	ISKVREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLSIHQL
Q13509	T166	Sugiyama	TUBB3 TUBB4	GMGTLLISKVREEYPDRIMNtFsVVPsPKVSDTVVEPYNAT
Q14004	S383	Sugiyama	CDK13 CDC2L CDC2L5 CHED KIAA1791	sRRRSPSYSRHSSYERGGDVsPsPyssSsWRRsRsPysPVL
Q14103	S190	Sugiyama	HNRNPD AUF1 HNRPD	KRAKAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVES
Q14152	T1379	Sugiyama	EIF3A EIF3S10 KIAA0139	EKDREsLRRTKNEtDEDGWttVRR_________________
Q14157	S467	Sugiyama	UBAP2L KIAA0144 NICE4	AAPPPPssPLPsKstsAPQMsPGssDNQsssPQPAQQKLKQ
Q14157	S470	Sugiyama	UBAP2L KIAA0144 NICE4	PPPssPLPsKstsAPQMsPGssDNQsssPQPAQQKLKQQKK
Q14160	S504	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	MKRSIEGRRsEACPCQPDsGsPLPAEEEKRLsAESGLSEDS
Q14258	S100	Sugiyama	TRIM25 EFP RNF147 ZNF147	DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14697	S58	Sugiyama	GANAB G2AN KIAA0088	FKtCEEssFCKRQRsIRPGLsPyRALLDSLQLGPDSLTVHL
Q14974	S12	Sugiyama	KPNB1 NTF97	_________MELITILEKtVsPDRLELEAAQKFLERAAVEN
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15293	T76	Sugiyama	RCN1 RCN	FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15596	S469	SIGNOR\|EPSD\|PSP	NCOA2 BHLHE75 SRC2 TIF2	HVSGMQATtPQGSNYALKMNsPsQSSPGMNPGQPTSMLsPR
Q15596	S487	SIGNOR\|EPSD\|PSP	NCOA2 BHLHE75 SRC2 TIF2	MNsPsQSSPGMNPGQPTSMLsPRHRMsPGVAGsPRIPPSQF
Q15596	S493	SIGNOR\|EPSD\|PSP	NCOA2 BHLHE75 SRC2 TIF2	SSPGMNPGQPTSMLsPRHRMsPGVAGsPRIPPSQFSPAGSL
Q15596	S499	SIGNOR\|EPSD\|PSP	NCOA2 BHLHE75 SRC2 TIF2	PGQPTSMLsPRHRMsPGVAGsPRIPPSQFSPAGSLHSPVGV
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q15642	T302	Sugiyama	TRIP10 CIP4 STOT STP	VEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTKRWP
Q15648	T1032	PSP	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	RKKADtEGKsPsHssSNRPFtPPtSTGGSKsPGsAGRsQtP
Q15773	S238	Sugiyama	MLF2	GAGGRRAEGPPRLAIQGPEDsPsRQsRRYDW__________
Q15797	S187	SIGNOR\|EPSD\|PSP	SMAD1 BSP1 MADH1 MADR1	PLNATFPDSFQQPNSHPFPHsPNSSYPNsPGSSSStYPHsP
Q15797	S195	SIGNOR\|EPSD\|PSP	SMAD1 BSP1 MADH1 MADR1	SFQQPNSHPFPHsPNSSYPNsPGSSSStYPHsPTSSDPGsP
Q15797	S206	SIGNOR\|EPSD\|PSP	SMAD1 BSP1 MADH1 MADR1	HsPNSSYPNsPGSSSStYPHsPTSSDPGsPFQMPADTPPPA
Q15797	S214	SIGNOR\|EPSD\|PSP	SMAD1 BSP1 MADH1 MADR1	NsPGSSSStYPHsPTSSDPGsPFQMPADTPPPAYLPPEDPM
Q16204	S244	Sugiyama	CCDC6 D10S170 TST1	LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16658	S234	Sugiyama	FSCN1 FAN1 HSN SNL	LEFRsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELF
Q27J81	S1204	Sugiyama	INF2 C14orf151 C14orf173	ALDtsLDKsFsEDAVtDssGsGtLPRARGRASKGTGKRRKK
Q27J81	T1199	Sugiyama	INF2 C14orf151 C14orf173	tAPEsALDtsLDKsFsEDAVtDssGsGtLPRARGRASKGTG
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q53EL6	S94	Sugiyama	PDCD4 H731	GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q5JSH3	S561	Sugiyama	WDR44 RPH11	KNAFDYFNNMRMKYNtEGRVsPsPsQEsLsssKsDTDtGVC
Q5T200	S879	Sugiyama	ZC3H13 KIAA0853	EKHRLLsQVVRPQEsRsLsPsHLTEDRQGRWKEEDRKPERK
Q5T5Y3	S563	Sugiyama	CAMSAP1	VAIVRADVVPQQADPEFPRAsPRALGLtANARsPQGQLDts
Q6GYQ0	S860	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	DEFIAERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQ
Q6PCE3	S175	Sugiyama	PGM2L1 BM32A	PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6PGQ7	S325	EPSD\|PSP	BORA C13orf34	GtNsNGITNPCIRSPYIDGCsPIKNWSPMRLQMYsGGTQYR
Q6PKG0	S774	Sugiyama	LARP1 KIAA0731 LARP	LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15	T494	Sugiyama	FIP1L1 FIP1 RHE	DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q6VN20	S369	Sugiyama	RANBP10 KIAA1464	RSLSSRsPKsQDsyPGsPsLsPRHGPsssHMHNTGADsPsC
Q7L2J0	S217	Sugiyama	MEPCE BCDIN3	LNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDItD
Q7L2J0	S60	Sugiyama	MEPCE BCDIN3	SGELRGGTERGPGRCAPsAGsPAAAVGREsPGAAAtsSSGP
Q7L2J0	S69	Sugiyama	MEPCE BCDIN3	RGPGRCAPsAGsPAAAVGREsPGAAAtsSSGPQAQQHRGGG
Q7L2J0	T213	Sugiyama	MEPCE BCDIN3	DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z2W4	S378	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	NWKsLtsWtNDQGARRKtVFsPtLPAARssLGsLQtPEAVt
Q7Z417	S692	Sugiyama	NUFIP2 KIAA1321 PIG1	IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q86VM9	S609	Sugiyama	ZC3H18 NHN1	HSSFSGSRSRsRsFsssPsPsPtPsPHRPsIRTKGEPAPPP
Q86VM9	T611	Sugiyama	ZC3H18 NHN1	SFSGSRSRsRsFsssPsPsPtPsPHRPsIRTKGEPAPPPGK
Q86VV8	S310	Sugiyama	RTTN	SYCHEARGTHHSQNPsPGsssPRPSVVGRTGQRPRGDGQDW
Q86W92	S1001	Sugiyama	PPFIBP1 KIAA1230	NLTHMLKEDDMFKDFAARsPsAsItDEDsNV__________
Q86W92	S999	Sugiyama	PPFIBP1 KIAA1230	INNLTHMLKEDDMFKDFAARsPsAsItDEDsNV________
Q86WR0	S187	Sugiyama	CCDC25	KKREKEEMKKKREMDELRSYssLMKVENMSSNQDGNDsDEF
Q86X29	S464	Sugiyama	LSR ILDR3 LISCH	SRPSRGPALtPIRDEEWGGHsPRsPRGWDQEPAREQAGGGW
Q8IWW6	S240	Sugiyama	ARHGAP12	SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6	T231	Sugiyama	ARHGAP12	QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IWX8	S815	Sugiyama	CHERP DAN26 SCAF6	RSQSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIP
Q8IWX8	S817	Sugiyama	CHERP DAN26 SCAF6	QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8	T819	Sugiyama	CHERP DAN26 SCAF6	RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8IZ21	S118	Sugiyama	PHACTR4 PRO2963	PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N3X1	T479	Sugiyama	FNBP4 FBP30 KIAA1014	FVRAtsPESTSRSSSKtGRDtPENGEtAIGAENsEKIDENs
Q8N543	S256	PSP	OGFOD1 KIAA1612 TPA1	WFHGPSLTRPPNYFEPPIPRsPHIPQDHEILYDWINPTYLD
Q8N556	S264	Sugiyama	AFAP1 AFAP	IKEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssD
Q8N556	S265	Sugiyama	AFAP1 AFAP	KEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssDG
Q8N684	S205	Sugiyama	CPSF7	IPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLPYF
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8N6T3	S343	Sugiyama	ARFGAP1 ARF1GAP	NIDQSFWETFGSAEPTKtRKsPssDsWtCADtstERRssDs
Q8N6T3	S345	Sugiyama	ARFGAP1 ARF1GAP	DQSFWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWE
Q8NBJ5	S612	Sugiyama	COLGALT1 GLT25D1 PSEC0241	QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NBJ7	T278	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	IDtADGsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPP
Q8ND56	S183	Sugiyama	LSM14A C19orf13 FAM61A RAP55 RAP55A	GSAFTQDTRsLKtQLsQGRssPQLDPLRKsPtMEQAVQtAs
Q8TC07	S675	Sugiyama	TBC1D15	TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q8TD19	S29	Sugiyama	NEK9 KIAA1995 NEK8 NERCC	RHCDsINSDFGSEsGGCGDssPGPSASQGPRAGGGAAEQEE
Q8WVV9	S75	Sugiyama	HNRNPLL HNRPLL SRRF BLOCK24	GGGRsFsQPEAGGsHHKVsVsPVVHVRGLCEsVVEADLVEA
Q8WXI9	S122	Sugiyama	GATAD2B KIAA1150	DEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSsRM
Q8WXI9	S135	Sugiyama	GATAD2B KIAA1150	ERGRLtPsPDIIVLsDNEAssPRsSsRMEERLKAANLEMFK
Q8WY36	S844	Sugiyama	BBX HBP2	KRKARKTKITHLVRtADGRVsPAGGTLDDKPKEQLQRSLPK
Q92466	S26	Sugiyama	DDB2	RPETQKTSEIVLRPRNKRsRsPLELEPEAKKLCAKGSGPSR
Q92530	S152	Sugiyama	PSMF1	SRIVSGIITPIHEQWEKANVssPHREFPPAtAREVDPLRIP
Q92530	S153	Sugiyama	PSMF1	RIVSGIITPIHEQWEKANVssPHREFPPAtAREVDPLRIPP
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96CW6	S302	Sugiyama	SLC7A6OS	SRQRMWSKYPLDVQKEFGyDsPHDLDsD_____________
Q96EB6	S47	PSP	SIRT1 SIR2L1	sPAGEPLRKRPRRDGPGLERsPGEPGGAAPEREVPAAARGC
Q96EN8	S530	Sugiyama	MOCOS	APSADSQADVIPAVMGRRsLsPQEDALTGSRVWNNSSTVNA
Q96MH2	S76	Sugiyama	HEXIM2 L3	EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96MH2	T74	Sugiyama	HEXIM2 L3	EDEDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRR
Q96PM5	S211	SIGNOR\|EPSD\|PSP	RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363	LDMTRYWRQLDDEVAQTPMPsEYQNMtVDILCNDCNGRSTV
Q96PM5	T217	SIGNOR\|EPSD\|PSP	RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363	WRQLDDEVAQTPMPsEYQNMtVDILCNDCNGRSTVQFHILG
Q96QK1	S783	Sugiyama	VPS35 MEM3 TCCCTA00141	tEQINKHFHNtLEHLRLRREsPEsEGPIyEGLIL_______
Q96T37	S670	Sugiyama	RBM15 OTT OTT1	GRHLDRsPEsDRPRKRHCAPsPDRsPELsssRDRYNsDNDR
Q99459	T385	Sugiyama	CDC5L KIAA0432 PCDC5RP	EAQNLMALtNVDtPLKGGLNtPLHEsDFsGVtPQRQVVQtP
Q99459	T396	Sugiyama	CDC5L KIAA0432 PCDC5RP	DtPLKGGLNtPLHEsDFsGVtPQRQVVQtPNtVLstPFRtP
Q99569	S314	Sugiyama	PKP4	RQTSNPNGPTPQyQtTARVGsPLTLTDAQTRVAsPSQGQVG
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BVG9	S16	Sugiyama	PTDSS2 PSS2	_____MRRGERRDAGGPRPEsPVPAGRAsLEEPPDGPSAGQ
Q9BWH6	S80	Sugiyama	RPAP1 KIAA1403	DNLPDLPPALVPsPPKRARPsPGHCLPEDEDPEERLRRHDQ
Q9BX95	S112	Sugiyama	SGPP1 SPP1	GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9BX95	T114	Sugiyama	SGPP1 SPP1	AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9C0C2	S1103	Sugiyama	TNKS1BP1 KIAA1741 TAB182	KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2	S435	Sugiyama	TNKS1BP1 KIAA1741 TAB182	DAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQG
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H0D6	T439	SIGNOR\|EPSD\|PSP	XRN2	KEKRKRMKRDQPAFtPsGILtPHALGsRNsPGsQVAsNPRQ
Q9H2U2	S316	Sugiyama	PPA2 HSPC124	SDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLGK__
Q9H2U2	S317	Sugiyama	PPA2 HSPC124	DSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLGK___
Q9H4A3	S1261	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H6F5	S91	Sugiyama	CCDC86 CYCLON	RLQQGAGLEsPQGQPEPGAAsPQRQQDLHLEsPQRQPEysP
Q9H773	S85	Sugiyama	DCTPP1 XTP3TPA CDA03	GELAELFQWKTDGEPGPQGWsPRERAALQEELSDVLIYLVA
Q9H7D7	S121	Sugiyama	WDR26 CDW2 MIP2 PRO0852	ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9HC35	S146	Sugiyama	EML4 C2orf2 EMAPL4	REKKEEsHsNDQsPQIRAsPsPQPssQPLQIHRQtPEsKNA
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQ39	T159	Sugiyama	RPS10P5 RPS10L	RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NQR4	S207	Sugiyama	NIT2 CUA002	HWELLQRSRAVDNQVyVAtAsPARDDKASYVAWGHSTVVNP
Q9NR19	S30	Sugiyama	ACSS2 ACAS2	sGsGSRGQEEAGAGGRARsWsPPPEVsRSAHVPSLQRYREL
Q9NTJ3	T44	Sugiyama	SMC4 CAPC SMC4L1	DGAssDAEPEPPsGRtEsPAtAAEtAsEELDNRSLEEILNS
Q9NUQ3	S97	Sugiyama	TXLNG CXorf15 ELRG LSR5	KHSLEEDEGsDFItENRNLVsPAyCtQEsREEIPGGEARTD
Q9NZL9	S16	Sugiyama	MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995	_____MVGREKELsIHFVPGsCRLVEEEVNIPNRRVLVtGA
Q9UGV2	S361	Sugiyama	NDRG3	sPFsRsVtsNQsDGtQESCEsPDVLDRHQTMEVsC______
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UHI6	T705	Sugiyama	DDX20 DP103 GEMIN3	sEstPVDDRIsLEQPPNGsDtPNPEKyQEsPGIQMKTRLKE
Q9UI15	T190	Sugiyama	TAGLN3 NP25	GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UII2	S39	Sugiyama	ATP5IF1 ATPI ATPIF1	TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UJU6	S232	Sugiyama	DBNL CMAP SH3P7 PP5423	RELREAARREQRyQEQGGEAsPQRtWEQQQEVVSRNRNEQE
Q9UKI8	S159	Sugiyama	TLK1 KIAA0137	IGGRGHKIsDyFEYQGGNGssPVRGIPPAIRsPQNsHsHst
Q9UKS6	S319	Sugiyama	PACSIN3	FEEWsLDtQRtIsRKEKGGRsPDEVtLtsIVPTRDGTAPPP
Q9UKS6	T324	Sugiyama	PACSIN3	LDtQRtIsRKEKGGRsPDEVtLtsIVPTRDGTAPPPQsPGs
Q9UNE7	S19	Sugiyama	STUB1 CHIP PP1131	__MKGKEEKEGGARLGAGGGsPEKsPsAQELKEQGNRLFVG
Q9UNE7	S23	Sugiyama	STUB1 CHIP PP1131	GKEEKEGGARLGAGGGsPEKsPsAQELKEQGNRLFVGRKYP
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UNZ2	S271	Sugiyama	NSFL1C UBXN2C	KAFTGEGQKLGstAPQVLstssPAQQAENEAKAsSSILIDE
Q9UPQ0	S217	Sugiyama	LIMCH1 KIAA1102	GRDDsFDsLDsFGsRsRQtPsPDVVLRGssDGRGsDsEsDL
Q9UPW0	S223	Sugiyama	FOXJ3 KIAA1041	AINTVTNKVTLYNTDQDGsDsPRSSLNNSLSDQSLASVNLN
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	T1655	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	RSRSGSSSKGRGPsPEGssstEssPEHPPKSRTARRGsRSs
Q9UQ35	T328	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APFsEPGttstQRPssPEtAtKQPssPYEDKDKDKKEKsAt
Q9UQ35	T866	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sGtPPRQGsItsPQANEQsVtPQRRsCFEssPDPELKsRtP
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2V2	S41	Sugiyama	CARHSP1	LDtPRsRERsPsPLRGNVVPsPLPtRRtRtFsAtVRASQGP
Q9Y4P8	T415	Sugiyama	WIPI2 CGI-50	LVTQTYGAAAGKGTYVPssPtRLAYTDDLGAVGGACLEDEA
Q9Y6G9	S207	Sugiyama	DYNC1LI1 DNCLI1	EQKLIRDFQEyVEPGEDFPAsPQRRNtAsQEDKDDsVVLPL

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	0.000001	5.960	0	0
Chromatin organization	R-HSA-4839726	0.000002	5.785	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	0.000002	5.606	0	0
Chromatin modifying enzymes	R-HSA-3247509	0.000008	5.084	0	0
Cell Cycle, Mitotic	R-HSA-69278	0.000018	4.739	0	0
Apoptotic execution phase	R-HSA-75153	0.000026	4.582	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	0.000031	4.508	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	0.000046	4.337	0	0
Cell Cycle	R-HSA-1640170	0.000050	4.297	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	0.000054	4.264	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	0.000111	3.954	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	0.000196	3.707	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	0.000203	3.693	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	0.000196	3.707	0	0
ISG15 antiviral mechanism	R-HSA-1169408	0.000197	3.705	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	0.000222	3.653	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	0.000248	3.606	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	0.000299	3.524	0	0
Nuclear import of Rev protein	R-HSA-180746	0.000287	3.542	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	0.000325	3.489	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	0.000325	3.489	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	0.000354	3.451	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	0.000368	3.434	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	0.000400	3.398	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	0.000421	3.376	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	0.000541	3.267	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	0.000541	3.267	0	0
NRAGE signals death through JNK	R-HSA-193648	0.000636	3.197	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	0.000689	3.162	0	0
Circadian clock	R-HSA-9909396	0.000743	3.129	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	0.000737	3.133	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	0.000797	3.098	0	0
Polo-like kinase mediated events	R-HSA-156711	0.000799	3.098	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	0.000915	3.039	0	0
Repression of WNT target genes	R-HSA-4641265	0.001092	2.962	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	0.001134	2.945	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	0.001128	2.948	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	0.001135	2.945	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	0.001134	2.945	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	0.001128	2.948	0	0
G0 and Early G1	R-HSA-1538133	0.001284	2.892	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	0.001381	2.860	0	0
PKMTs methylate histone lysines	R-HSA-3214841	0.001381	2.860	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	0.001577	2.802	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	0.001577	2.802	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	0.001566	2.805	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	0.001956	2.709	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	0.002076	2.683	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	0.002221	2.653	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	0.002221	2.653	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	0.002169	2.664	0	0
Signaling by Hippo	R-HSA-2028269	0.002150	2.668	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	0.002478	2.606	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	0.002478	2.606	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	0.002384	2.623	0	0
Regulation of TP53 Activity	R-HSA-5633007	0.002476	2.606	0	0
Signaling by NTRKs	R-HSA-166520	0.002550	2.593	0	0
Signaling by NOTCH1	R-HSA-1980143	0.002731	2.564	0	0
Gene expression (Transcription)	R-HSA-74160	0.002866	2.543	1	0
Notch-HLH transcription pathway	R-HSA-350054	0.003296	2.482	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	0.003429	2.465	0	0
G1/S-Specific Transcription	R-HSA-69205	0.003659	2.437	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	0.003879	2.411	0	0
tRNA processing in the nucleus	R-HSA-6784531	0.003965	2.402	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	0.004233	2.373	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	0.004261	2.371	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	0.004464	2.350	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	0.004523	2.345	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	0.004906	2.309	0	0
Epigenetic regulation of gene expression	R-HSA-212165	0.004891	2.311	0	0
Deadenylation of mRNA	R-HSA-429947	0.005281	2.277	0	0
Metabolism of non-coding RNA	R-HSA-194441	0.005686	2.245	0	0
snRNP Assembly	R-HSA-191859	0.005686	2.245	0	0
HIV Life Cycle	R-HSA-162587	0.005654	2.248	1	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	0.005956	2.225	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	0.006222	2.206	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	0.006222	2.206	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	0.006485	2.188	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	0.006631	2.178	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	0.006786	2.168	1	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	0.007292	2.137	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	0.007475	2.126	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	0.007858	2.105	1	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	0.008219	2.085	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	0.008356	2.078	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	0.009120	2.040	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	0.009120	2.040	0	0
MITF-M-dependent gene expression	R-HSA-9856651	0.009001	2.046	0	0
RUNX2 regulates bone development	R-HSA-8941326	0.009257	2.034	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	0.009551	2.020	0	0
mRNA 3'-end processing	R-HSA-72187	0.010171	1.993	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	0.009970	2.001	0	0
Signaling by ALK in cancer	R-HSA-9700206	0.009970	2.001	0	0
Cardiogenesis	R-HSA-9733709	0.011511	1.939	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	0.011945	1.923	0	0
Death Receptor Signaling	R-HSA-73887	0.012295	1.910	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	0.012451	1.905	0	0
Type I hemidesmosome assembly	R-HSA-446107	0.013284	1.877	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	0.013284	1.877	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	0.014395	1.842	0	0
Cellular response to heat stress	R-HSA-3371556	0.013685	1.864	0	0
Apoptosis	R-HSA-109581	0.013762	1.861	0	0
G alpha (12/13) signalling events	R-HSA-416482	0.014175	1.848	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	0.014127	1.850	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	0.014006	1.854	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	0.014805	1.830	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	0.016550	1.781	0	0
Activation of the pre-replicative complex	R-HSA-68962	0.017034	1.769	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	0.017091	1.767	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	0.017427	1.759	0	0
Signaling by LTK	R-HSA-9842663	0.016550	1.781	0	0
Heme signaling	R-HSA-9707616	0.017427	1.759	0	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	0.018992	1.721	0	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	0.018992	1.721	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	0.018992	1.721	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	0.018992	1.721	0	0
Phosphorylation of Emi1	R-HSA-176417	0.018992	1.721	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	0.018992	1.721	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	0.018748	1.727	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	0.017807	1.749	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	0.018225	1.739	0	0
G2/M Transition	R-HSA-69275	0.019684	1.706	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	0.019999	1.699	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	0.020188	1.695	0	0
G1/S Transition	R-HSA-69206	0.020563	1.687	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	0.021495	1.668	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	0.021389	1.670	0	0
Mitotic G2-G2/M phases	R-HSA-453274	0.022347	1.651	0	0
Estrogen-dependent gene expression	R-HSA-9018519	0.020655	1.685	1	1
Mitotic Prophase	R-HSA-68875	0.021274	1.672	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	0.021029	1.677	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	0.022177	1.654	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	0.026517	1.576	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	0.026517	1.576	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	0.026517	1.576	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	0.026517	1.576	0	0
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	0.026517	1.576	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	0.026517	1.576	0	0
Regulation of KIT signaling	R-HSA-1433559	0.027351	1.563	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	0.027444	1.562	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	0.027260	1.564	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	0.027260	1.564	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	0.027260	1.564	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	0.027260	1.564	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	0.027260	1.564	0	0
mRNA Splicing	R-HSA-72172	0.027604	1.559	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	0.027444	1.562	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	0.027444	1.562	0	0
Signaling by WNT in cancer	R-HSA-4791275	0.023571	1.628	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	0.026839	1.571	0	0
Activation of ATR in response to replication stress	R-HSA-176187	0.027444	1.562	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	0.025671	1.591	0	0
HATs acetylate histones	R-HSA-3214847	0.024082	1.618	0	0
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	R-HSA-210746	0.027636	1.559	0	0
CREB phosphorylation	R-HSA-199920	0.027636	1.559	0	0
Gene Silencing by RNA	R-HSA-211000	0.029926	1.524	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	0.030372	1.518	0	0
Signaling by NOTCH3	R-HSA-9012852	0.030467	1.516	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	0.030983	1.509	0	0
RNA Polymerase II Transcription	R-HSA-73857	0.031731	1.499	1	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	0.031749	1.498	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	0.031820	1.497	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	0.032660	1.486	1	1
Signaling by ALK	R-HSA-201556	0.033037	1.481	0	0
MECP2 regulates transcription factors	R-HSA-9022707	0.038284	1.417	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	0.038284	1.417	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	0.038284	1.417	0	0
M Phase	R-HSA-68886	0.034481	1.462	0	0
Cell Cycle Checkpoints	R-HSA-69620	0.037578	1.425	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	0.040192	1.396	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	0.040192	1.396	0	0
Activation of BH3-only proteins	R-HSA-114452	0.040192	1.396	0	0
Interleukin-37 signaling	R-HSA-9008059	0.040192	1.396	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	0.040530	1.392	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	0.040530	1.392	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	0.040530	1.392	0	0
Signalling to ERKs	R-HSA-187687	0.041740	1.379	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	0.042084	1.376	0	0
Signaling by AXIN mutants	R-HSA-4839735	0.042084	1.376	0	0
Signaling by AMER1 mutants	R-HSA-4839748	0.042084	1.376	0	0
TGFBR3 expression	R-HSA-9839394	0.043992	1.357	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	0.047462	1.324	0	0
RNA Polymerase III Transcription	R-HSA-74158	0.047462	1.324	0	0
Mitotic Prometaphase	R-HSA-68877	0.044510	1.352	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	0.049922	1.302	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	0.046452	1.333	0	0
S Phase	R-HSA-69242	0.049474	1.306	0	0
Regulation of beta-cell development	R-HSA-186712	0.046452	1.333	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	0.047700	1.321	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	0.050970	1.293	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	0.050970	1.293	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	0.050970	1.293	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	0.050970	1.293	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	0.051194	1.291	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	0.051223	1.291	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	0.052664	1.278	0	0
NGF-stimulated transcription	R-HSA-9031628	0.053212	1.274	0	0
Amplification of signal from the kinetochores	R-HSA-141424	0.053576	1.271	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	0.053576	1.271	0	0
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	0.055016	1.260	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	0.055016	1.260	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	0.056058	1.251	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	0.058843	1.230	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	0.058843	1.230	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	0.058843	1.230	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	0.058843	1.230	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	0.065271	1.185	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	0.060761	1.216	0	0
Signaling by EGFR	R-HSA-177929	0.063629	1.196	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	0.058885	1.230	0	0
Nuclear RNA decay	R-HSA-9930044	0.060175	1.221	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	0.063629	1.196	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	0.058843	1.230	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	0.065678	1.183	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	0.066864	1.175	0	0
Cellular Senescence	R-HSA-2559583	0.067104	1.173	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	0.068033	1.167	0	0
Inositol phosphate metabolism	R-HSA-1483249	0.069117	1.160	0	0
Signal Transduction	R-HSA-162582	0.069286	1.159	1	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	0.070858	1.150	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	0.071123	1.148	0	0
IGF1R signaling cascade	R-HSA-2428924	0.073653	1.133	0	0
RAF activation	R-HSA-5673000	0.076504	1.116	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	0.076618	1.116	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	0.076618	1.116	0	0
Regulation of TP53 Expression	R-HSA-6804754	0.090270	1.044	0	0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	0.090270	1.044	0	0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	0.090270	1.044	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	0.080359	1.095	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	0.080359	1.095	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	0.080359	1.095	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	0.080359	1.095	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	0.080359	1.095	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	0.082346	1.084	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	0.078046	1.108	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	0.086283	1.064	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	0.079104	1.102	1	1
RNA Polymerase II Transcription Elongation	R-HSA-75955	0.086637	1.062	1	1
AURKA Activation by TPX2	R-HSA-8854518	0.086954	1.061	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	0.089906	1.046	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	0.086283	1.064	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	0.078151	1.107	0	0
Signal attenuation	R-HSA-74749	0.082346	1.084	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	0.086563	1.063	0	0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	0.090270	1.044	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	0.080126	1.096	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	0.083836	1.077	0	0
Formation of intermediate mesoderm	R-HSA-9761174	0.082346	1.084	0	0
Metabolism of RNA	R-HSA-8953854	0.077822	1.109	0	0
HIV Infection	R-HSA-162906	0.087395	1.059	1	0
Signaling by ERBB2	R-HSA-1227986	0.090757	1.042	0	0
DCC mediated attractive signaling	R-HSA-418885	0.092805	1.032	0	0
RET signaling	R-HSA-8853659	0.095297	1.021	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	0.095634	1.019	0	0
Long-term potentiation	R-HSA-9620244	0.098072	1.008	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	0.099172	1.004	0	0
Drug resistance of KIT mutants	R-HSA-9669937	0.117568	0.930	0	0
KIT mutants bind TKIs	R-HSA-9669921	0.117568	0.930	0	0
Nilotinib-resistant KIT mutants	R-HSA-9669926	0.117568	0.930	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	0.117568	0.930	0	0
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	0.117568	0.930	0	0
Imatinib-resistant KIT mutants	R-HSA-9669917	0.117568	0.930	0	0
Sunitinib-resistant KIT mutants	R-HSA-9669934	0.117568	0.930	0	0
Masitinib-resistant KIT mutants	R-HSA-9669924	0.117568	0.930	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	0.117568	0.930	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	0.117568	0.930	0	0
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	0.117568	0.930	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	0.117568	0.930	0	0
Dasatinib-resistant KIT mutants	R-HSA-9669914	0.117568	0.930	0	0
Regorafenib-resistant KIT mutants	R-HSA-9669929	0.117568	0.930	0	0
Sorafenib-resistant KIT mutants	R-HSA-9669936	0.117568	0.930	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	0.104748	0.980	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	0.104748	0.980	0	0
G2/M DNA replication checkpoint	R-HSA-69478	0.104748	0.980	0	0
Signaling by APC mutants	R-HSA-4839744	0.100878	0.996	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	0.100878	0.996	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	0.100878	0.996	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	0.100878	0.996	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	0.111234	0.954	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	0.120661	0.918	0	0
Centrosome maturation	R-HSA-380287	0.104244	0.982	0	0
Ovarian tumor domain proteases	R-HSA-5689896	0.105614	0.976	0	0
FOXO-mediated transcription	R-HSA-9614085	0.103639	0.984	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	0.102147	0.991	0	0
MTOR signalling	R-HSA-165159	0.102147	0.991	0	0
Homology Directed Repair	R-HSA-5693538	0.111745	0.952	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	0.108596	0.964	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	0.110700	0.956	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	0.108638	0.964	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	0.108884	0.963	0	0
Differentiation of T cells	R-HSA-9945266	0.108884	0.963	0	0
Deubiquitination	R-HSA-5688426	0.112981	0.947	0	0
Programmed Cell Death	R-HSA-5357801	0.115856	0.936	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	0.120661	0.918	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	0.121143	0.917	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	0.121143	0.917	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	0.122581	0.912	0	0
Regulation of endogenous retroelements	R-HSA-9842860	0.124081	0.906	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	0.124143	0.906	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	0.124143	0.906	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	0.124143	0.906	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	0.221320	0.655	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	0.221320	0.655	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	0.221320	0.655	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	0.130298	0.885	0	0
MET interacts with TNS proteins	R-HSA-8875513	0.130298	0.885	0	0
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	0.173491	0.761	0	0
HCN channels	R-HSA-1296061	0.173491	0.761	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	0.173491	0.761	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	0.173491	0.761	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	0.173491	0.761	0	0
Signaling by MAP2K mutants	R-HSA-9652169	0.173491	0.761	0	0
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	0.312879	0.505	0	0
t(4;14) translocations of FGFR3	R-HSA-2033515	0.312879	0.505	0	0
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	0.312879	0.505	0	0
Signaling by FGFR3 fusions in cancer	R-HSA-8853334	0.312879	0.505	0	0
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	0.312879	0.505	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	0.312879	0.505	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	0.312879	0.505	0	0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	0.312879	0.505	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	0.312879	0.505	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	0.312879	0.505	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	0.312879	0.505	0	0
Intestinal infectious diseases	R-HSA-8942233	0.312879	0.505	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	0.312879	0.505	0	0
Defective VWF binding to collagen type I	R-HSA-9845622	0.312879	0.505	0	0
Signaling by kinase domain mutants of KIT	R-HSA-9669933	0.312879	0.505	0	0
Defective MMADHC causes MMAHCD	R-HSA-3359473	0.312879	0.505	0	0
Defective ALG1 causes CDG-1k	R-HSA-4549380	0.312879	0.505	0	0
XAV939 stabilizes AXIN	R-HSA-5545619	0.312879	0.505	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	0.131637	0.881	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	0.131637	0.881	0	0
Regulation of PTEN localization	R-HSA-8948747	0.131637	0.881	0	0
SOS-mediated signalling	R-HSA-112412	0.131637	0.881	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	0.131637	0.881	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	0.218552	0.660	0	0
IRS activation	R-HSA-74713	0.218552	0.660	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	0.218552	0.660	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	0.160626	0.794	0	0
RSK activation	R-HSA-444257	0.160626	0.794	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	0.160626	0.794	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	0.142989	0.845	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	0.142989	0.845	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	0.142989	0.845	0	0
Pervasive developmental disorders	R-HSA-9005895	0.142989	0.845	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	0.142989	0.845	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	0.142989	0.845	0	0
Disorders of Nervous System Development	R-HSA-9697154	0.142989	0.845	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	0.142989	0.845	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	0.142989	0.845	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	0.142989	0.845	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	0.142989	0.845	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	0.142989	0.845	0	0
GP1b-IX-V activation signalling	R-HSA-430116	0.191317	0.718	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	0.191317	0.718	0	0
ALK mutants bind TKIs	R-HSA-9700645	0.191317	0.718	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	0.264447	0.578	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	0.264447	0.578	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	0.393676	0.405	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	0.393676	0.405	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	0.393676	0.405	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	0.393676	0.405	0	0
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	0.393676	0.405	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	0.393676	0.405	0	0
Defective F8 sulfation at Y1699	R-HSA-9674519	0.393676	0.405	0	0
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	0.393676	0.405	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	0.393676	0.405	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	0.393676	0.405	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	0.393676	0.405	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	0.393676	0.405	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	0.393676	0.405	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	0.393676	0.405	0	0
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	0.393676	0.405	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	0.393676	0.405	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	0.393676	0.405	0	0
Disorders of Developmental Biology	R-HSA-9675151	0.126217	0.899	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	0.126217	0.899	0	0
MAPK3 (ERK1) activation	R-HSA-110056	0.223319	0.651	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	0.126383	0.898	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	0.190735	0.720	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	0.310356	0.508	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	0.164317	0.784	0	0
PKA activation	R-HSA-163615	0.164317	0.784	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	0.164317	0.784	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	0.256262	0.591	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	0.216267	0.665	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	0.184893	0.733	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	0.138374	0.859	0	0
Formation of the Early Elongation Complex	R-HSA-113418	0.138374	0.859	0	0
Phosphorylation of the APC/C	R-HSA-176412	0.242656	0.615	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	0.242656	0.615	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	0.289802	0.538	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	0.289802	0.538	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	0.355642	0.449	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	0.355642	0.449	0	0
Synthesis of PIPs in the nucleus	R-HSA-8847453	0.355642	0.449	0	0
PTK6 Expression	R-HSA-8849473	0.355642	0.449	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	0.355642	0.449	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	0.355642	0.449	0	0
DAG1 core M1 glycosylations	R-HSA-8932506	0.355642	0.449	0	0
PLC-gamma1 signalling	R-HSA-167021	0.464977	0.333	0	0
Activated NTRK3 signals through PLCG1	R-HSA-9034793	0.464977	0.333	0	0
Defective MMACHC causes MAHCC	R-HSA-3359474	0.464977	0.333	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	0.464977	0.333	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	0.464977	0.333	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	0.464977	0.333	0	0
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	0.464977	0.333	0	0
Defective DPM3 causes DPM3-CDG	R-HSA-4719360	0.464977	0.333	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	0.464977	0.333	0	0
Defective DPM1 causes DPM1-CDG	R-HSA-4717374	0.464977	0.333	0	0
Defective DPM2 causes DPM2-CDG	R-HSA-4719377	0.464977	0.333	0	0
Defective GSS causes GSS deficiency	R-HSA-5579006	0.464977	0.333	0	0
MET activates PTPN11	R-HSA-8865999	0.464977	0.333	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	0.228565	0.641	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	0.140146	0.853	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	0.269715	0.569	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	0.269715	0.569	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	0.269715	0.569	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	0.269715	0.569	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	0.269715	0.569	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	0.215064	0.667	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	0.323626	0.490	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	0.323626	0.490	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	0.145083	0.838	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	0.251435	0.600	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	0.202413	0.694	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	0.234926	0.629	1	1
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	0.234926	0.629	1	1
Specification of primordial germ cells	R-HSA-9827857	0.297263	0.527	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	0.297263	0.527	0	0
DAG1 core M2 glycosylations	R-HSA-8932504	0.399818	0.398	0	0
MET receptor recycling	R-HSA-8875656	0.399818	0.398	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	0.399818	0.398	0	0
HIV elongation arrest and recovery	R-HSA-167287	0.255322	0.593	1	1
Pausing and recovery of HIV elongation	R-HSA-167290	0.255322	0.593	1	1
FGFR3 mutant receptor activation	R-HSA-2033514	0.357453	0.447	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	0.357453	0.447	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	0.357453	0.447	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	0.238044	0.623	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	0.325127	0.488	0	0
PKA activation in glucagon signalling	R-HSA-164378	0.325127	0.488	0	0
Interleukin receptor SHC signaling	R-HSA-912526	0.298673	0.525	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	0.239218	0.621	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	0.239218	0.621	1	1
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	0.185061	0.733	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	0.185061	0.733	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	0.239154	0.621	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	0.239154	0.621	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	0.239154	0.621	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	0.353144	0.452	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	0.353144	0.452	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	0.391034	0.408	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	0.391034	0.408	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	0.391034	0.408	0	0
MAPK1 (ERK2) activation	R-HSA-112411	0.442518	0.354	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	0.527897	0.277	0	0
Activated NTRK2 signals through PLCG1	R-HSA-9026527	0.527897	0.277	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	0.527897	0.277	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	0.527897	0.277	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	0.527897	0.277	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	0.527897	0.277	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	0.527897	0.277	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	0.164631	0.783	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	0.273695	0.563	0	0
HIV Transcription Initiation	R-HSA-167161	0.273695	0.563	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	0.273695	0.563	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	0.131208	0.882	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	0.196103	0.708	1	1
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	0.236813	0.626	0	0
Translation initiation complex formation	R-HSA-72649	0.253112	0.597	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	0.271192	0.567	0	0
Formation of definitive endoderm	R-HSA-9823730	0.381162	0.419	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	0.314340	0.503	0	0
HDACs deacetylate histones	R-HSA-3214815	0.268261	0.571	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	0.169162	0.772	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	0.248199	0.605	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	0.340678	0.468	0	0
Erythropoietin activates RAS	R-HSA-9027284	0.424153	0.372	0	0
Processive synthesis on the lagging strand	R-HSA-69183	0.424153	0.372	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	0.424153	0.372	0	0
Translesion synthesis by REV1	R-HSA-110312	0.424153	0.372	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	0.424153	0.372	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	0.424153	0.372	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	0.424153	0.372	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	0.189292	0.723	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	0.309431	0.509	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	0.283684	0.547	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	0.371600	0.430	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	0.371600	0.430	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	0.279586	0.553	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	0.409040	0.388	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	0.483478	0.316	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	0.483478	0.316	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	0.483478	0.316	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	0.483478	0.316	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	0.396043	0.402	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	0.396043	0.402	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	0.346057	0.461	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	0.309308	0.510	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	0.384530	0.415	0	0
Translesion synthesis by POLI	R-HSA-5656121	0.456625	0.340	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	0.298034	0.526	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	0.436652	0.360	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	0.436652	0.360	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	0.436652	0.360	0	0
Amino acids regulate mTORC1	R-HSA-9639288	0.355756	0.449	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	0.355756	0.449	0	0
MAP2K and MAPK activation	R-HSA-5674135	0.414347	0.383	0	0
Signaling by RAF1 mutants	R-HSA-9656223	0.414347	0.383	0	0
Signaling by Erythropoietin	R-HSA-9006335	0.444566	0.352	0	0
Late endosomal microautophagy	R-HSA-9615710	0.444566	0.352	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	0.444566	0.352	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	0.488296	0.311	0	0
Translesion synthesis by POLK	R-HSA-5655862	0.488296	0.311	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	0.522518	0.282	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	0.522518	0.282	0	0
DAG1 core M3 glycosylations	R-HSA-8932505	0.522518	0.282	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	0.522518	0.282	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	0.583421	0.234	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	0.583421	0.234	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	0.583421	0.234	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	0.583421	0.234	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	0.583421	0.234	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	0.583421	0.234	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	0.583421	0.234	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	0.408078	0.389	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	0.468480	0.329	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	0.490633	0.309	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	0.490633	0.309	0	0
Separation of Sister Chromatids	R-HSA-2467813	0.346122	0.461	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	0.410460	0.387	1	1
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	0.519039	0.285	0	0
EGFR downregulation	R-HSA-182971	0.492064	0.308	0	0
Signaling by ERBB4	R-HSA-1236394	0.449001	0.348	0	0
MET promotes cell motility	R-HSA-8875878	0.493057	0.307	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	0.559523	0.252	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	0.464611	0.333	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	0.481132	0.318	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	0.511360	0.291	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	0.577353	0.239	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	0.594431	0.226	0	0
Switching of origins to a post-replicative state	R-HSA-69052	0.558658	0.253	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	0.581894	0.235	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	0.591216	0.228	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	0.604787	0.218	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	0.604787	0.218	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	0.604787	0.218	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	0.604787	0.218	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	0.627224	0.203	0	0
Adenylate cyclase activating pathway	R-HSA-170660	0.627224	0.203	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	0.627224	0.203	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	0.627224	0.203	0	0
PRC2 methylates histones and DNA	R-HSA-212300	0.623456	0.205	0	0
PTEN Regulation	R-HSA-6807070	0.397334	0.401	0	0
Transcription of the HIV genome	R-HSA-167172	0.163520	0.786	1	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	0.424804	0.372	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	0.485151	0.314	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	0.485151	0.314	0	0
Nucleotide Excision Repair	R-HSA-5696398	0.220163	0.657	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	0.325477	0.487	0	0
Oncogenic MAPK signaling	R-HSA-6802957	0.129520	0.888	0	0
HIV Transcription Elongation	R-HSA-167169	0.239218	0.621	1	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	0.374126	0.427	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	0.374126	0.427	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	0.485151	0.314	0	0
Signaling by SCF-KIT	R-HSA-1433557	0.193908	0.712	0	0
Crosslinking of collagen fibrils	R-HSA-2243919	0.577353	0.239	0	0
HCMV Early Events	R-HSA-9609690	0.594944	0.226	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	0.297404	0.527	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	0.428386	0.368	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	0.190957	0.719	0	0
Adipogenesis	R-HSA-9843745	0.166377	0.779	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	0.182577	0.739	0	0
Mitotic Anaphase	R-HSA-68882	0.176340	0.754	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	0.370522	0.431	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	0.144726	0.839	0	0
MET activates RAS signaling	R-HSA-8851805	0.323626	0.490	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	0.184680	0.734	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	0.381162	0.419	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	0.140808	0.851	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	0.131051	0.883	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	0.555099	0.256	0	0
p75NTR recruits signalling complexes	R-HSA-209543	0.142989	0.845	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	0.305686	0.515	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	0.574991	0.240	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	0.166246	0.779	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	0.145805	0.836	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	0.239218	0.621	1	1
Downstream signaling of activated FGFR1	R-HSA-5654687	0.428386	0.368	0	0
DNA Replication Pre-Initiation	R-HSA-69002	0.445629	0.351	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	0.169057	0.772	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	0.391034	0.408	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	0.196774	0.706	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	0.381162	0.419	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	0.463884	0.334	0	0
Frs2-mediated activation	R-HSA-170968	0.166246	0.779	0	0
Insulin receptor signalling cascade	R-HSA-74751	0.294343	0.531	0	0
Signaling by NOTCH	R-HSA-157118	0.291944	0.535	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	0.289802	0.538	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	0.357453	0.447	0	0
G2/M Checkpoints	R-HSA-69481	0.130839	0.883	0	0
Regulation of the apoptosome activity	R-HSA-9627069	0.483478	0.316	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	0.315231	0.501	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	0.488296	0.311	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	0.471726	0.326	1	1
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	0.537987	0.269	0	0
Interleukin-15 signaling	R-HSA-8983432	0.142989	0.845	0	0
Nephron development	R-HSA-9831926	0.548751	0.261	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	0.436652	0.360	0	0
Signaling by FGFR3	R-HSA-5654741	0.133579	0.874	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	0.268231	0.571	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	0.237233	0.625	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	0.184163	0.735	1	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	0.269715	0.569	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	0.222565	0.653	1	1
CRMPs in Sema3A signaling	R-HSA-399956	0.391034	0.408	0	0
Formation of apoptosome	R-HSA-111458	0.483478	0.316	0	0
Regulation of CDH11 function	R-HSA-9762292	0.483478	0.316	0	0
PI3K/AKT activation	R-HSA-198203	0.483478	0.316	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	0.559523	0.252	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	0.480151	0.319	0	0
Generic Transcription Pathway	R-HSA-212436	0.134333	0.872	1	0
DNA Double Strand Break Response	R-HSA-5693606	0.234964	0.629	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	0.146753	0.833	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	0.146753	0.833	0	0
RNA Polymerase I Transcription	R-HSA-73864	0.510930	0.292	0	0
Signaling by RAS mutants	R-HSA-6802949	0.239154	0.621	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	0.581894	0.235	0	0
Synthesis of DNA	R-HSA-69239	0.626219	0.203	0	0
p75NTR signals via NF-kB	R-HSA-193639	0.216267	0.665	0	0
Signaling by VEGF	R-HSA-194138	0.391775	0.407	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	0.306408	0.514	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	0.589145	0.230	0	0
PIP3 activates AKT signaling	R-HSA-1257604	0.249902	0.602	0	0
TNF signaling	R-HSA-75893	0.283684	0.547	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	0.191317	0.718	0	0
Interleukin-6 signaling	R-HSA-1059683	0.166246	0.779	0	0
Formation of axial mesoderm	R-HSA-9796292	0.166246	0.779	0	0
mTORC1-mediated signalling	R-HSA-166208	0.142473	0.846	0	0
Activation of RAC1	R-HSA-428540	0.289802	0.538	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	0.251435	0.600	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	0.274843	0.561	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	0.325127	0.488	0	0
G2/M DNA damage checkpoint	R-HSA-69473	0.154337	0.812	0	0
Regulation of gap junction activity	R-HSA-191650	0.527897	0.277	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	0.184680	0.734	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	0.250796	0.601	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	0.534787	0.272	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	0.541174	0.267	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	0.577353	0.239	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	0.594431	0.226	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	0.591216	0.228	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	0.274843	0.561	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	0.371600	0.430	0	0
Laminin interactions	R-HSA-3000157	0.542342	0.266	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	0.331294	0.480	0	0
UCH proteinases	R-HSA-5689603	0.480151	0.319	0	0
Signaling by MET	R-HSA-6806834	0.218771	0.660	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	0.144726	0.839	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	0.144726	0.839	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	0.519039	0.285	0	0
Integration of provirus	R-HSA-162592	0.559523	0.252	0	0
Apoptotic factor-mediated response	R-HSA-111471	0.548751	0.261	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	0.594431	0.226	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	0.581894	0.235	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	0.602985	0.220	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	0.593694	0.226	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	0.239154	0.621	0	0
Signaling by FGFR4	R-HSA-5654743	0.309431	0.509	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	0.414347	0.383	0	0
DAP12 signaling	R-HSA-2424491	0.468480	0.329	0	0
Signalling to RAS	R-HSA-167044	0.228565	0.641	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	0.436652	0.360	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	0.492064	0.308	0	0
Resolution of D-Loop Structures	R-HSA-5693537	0.560216	0.252	0	0
Prolonged ERK activation events	R-HSA-169893	0.242656	0.615	0	0
Neurexins and neuroligins	R-HSA-6794361	0.476113	0.322	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	0.177253	0.751	0	0
Neurodegenerative Diseases	R-HSA-8863678	0.177253	0.751	0	0
Signaling by NOTCH2	R-HSA-1980145	0.581894	0.235	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	0.218552	0.660	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	0.218552	0.660	0	0
Calcineurin activates NFAT	R-HSA-2025928	0.191317	0.718	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	0.190735	0.720	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	0.289802	0.538	0	0
Adrenoceptors	R-HSA-390696	0.399818	0.398	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	0.442518	0.354	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	0.527897	0.277	0	0
Negative regulation of MET activity	R-HSA-6807004	0.381162	0.419	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	0.371600	0.430	0	0
IRS-mediated signalling	R-HSA-112399	0.299351	0.524	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	0.583421	0.234	0	0
DNA strand elongation	R-HSA-69190	0.515253	0.288	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	0.537987	0.269	0	0
Chylomicron remodeling	R-HSA-8963901	0.627224	0.203	0	0
Selective autophagy	R-HSA-9663891	0.553775	0.257	0	0
Cilium Assembly	R-HSA-5617833	0.383080	0.417	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	0.228565	0.641	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	0.228565	0.641	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	0.386321	0.413	0	0
Mismatch Repair	R-HSA-5358508	0.164317	0.784	0	0
Cyclin D associated events in G1	R-HSA-69231	0.327656	0.485	0	0
G1 Phase	R-HSA-69236	0.327656	0.485	0	0
Intracellular signaling by second messengers	R-HSA-9006925	0.173791	0.760	0	0
DNA Repair	R-HSA-73894	0.377910	0.423	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	0.518501	0.285	0	0
Interleukin-2 signaling	R-HSA-9020558	0.522518	0.282	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	0.354069	0.451	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	0.263802	0.579	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	0.166246	0.779	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	0.424153	0.372	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	0.542342	0.266	0	0
Signaling by ROBO receptors	R-HSA-376176	0.432222	0.364	0	0
Pexophagy	R-HSA-9664873	0.223319	0.651	0	0
Macroautophagy	R-HSA-1632852	0.335704	0.474	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	0.371600	0.430	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	0.202386	0.694	1	0
Signaling by FGFR1	R-HSA-5654736	0.547942	0.261	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	0.173491	0.761	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	0.173491	0.761	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	0.264447	0.578	0	0
Inhibition of nitric oxide production	R-HSA-9636249	0.464977	0.333	0	0
FasL/ CD95L signaling	R-HSA-75157	0.464977	0.333	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	0.274843	0.561	0	0
Signaling by NOTCH4	R-HSA-9013694	0.332428	0.478	0	0
GPER1 signaling	R-HSA-9634597	0.551132	0.259	0	0
Autophagy	R-HSA-9612973	0.269922	0.569	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	0.366631	0.436	0	0
Mitochondrial biogenesis	R-HSA-1592230	0.289686	0.538	0	0
Signaling by WNT	R-HSA-195721	0.443601	0.353	0	0
Oncogene Induced Senescence	R-HSA-2559585	0.602985	0.220	0	0
Protein-protein interactions at synapses	R-HSA-6794362	0.279827	0.553	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	0.218552	0.660	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	0.228565	0.641	0	0
Myogenesis	R-HSA-525793	0.215064	0.667	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	0.399818	0.398	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	0.420394	0.376	0	0
Regulation of TP53 Degradation	R-HSA-6804757	0.450151	0.347	0	0
RAF/MAP kinase cascade	R-HSA-5673001	0.434814	0.362	0	0
Interleukin-6 family signaling	R-HSA-6783589	0.516811	0.287	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	0.256277	0.591	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	0.442518	0.354	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	0.532312	0.274	0	0
Nervous system development	R-HSA-9675108	0.143618	0.843	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	0.516811	0.287	0	0
Germ layer formation at gastrulation	R-HSA-9754189	0.577353	0.239	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	0.152801	0.816	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	0.594431	0.226	0	0
Developmental Biology	R-HSA-1266738	0.459703	0.338	0	0
ESR-mediated signaling	R-HSA-8939211	0.394259	0.404	1	0
MAPK family signaling cascades	R-HSA-5683057	0.289694	0.538	0	0
Axon guidance	R-HSA-422475	0.280081	0.553	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	0.362569	0.441	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	0.312879	0.505	0	0
Interleukin-33 signaling	R-HSA-9014843	0.393676	0.405	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	0.393676	0.405	0	0
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	0.393676	0.405	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	0.310356	0.508	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	0.164317	0.784	0	0
Cell-extracellular matrix interactions	R-HSA-446353	0.216267	0.665	0	0
Negative regulation of FLT3	R-HSA-9706369	0.242656	0.615	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	0.464977	0.333	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	0.169548	0.771	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	0.357453	0.447	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	0.325127	0.488	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	0.325127	0.488	0	0
Unwinding of DNA	R-HSA-176974	0.442518	0.354	0	0
Alanine metabolism	R-HSA-8964540	0.527897	0.277	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	0.527897	0.277	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	0.236813	0.626	0	0
PI3K Cascade	R-HSA-109704	0.304400	0.517	0	0
Kinesins	R-HSA-983189	0.347507	0.459	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	0.522518	0.282	0	0
Suppression of autophagy	R-HSA-9636569	0.583421	0.234	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	0.583421	0.234	0	0
NF-kB is activated and signals survival	R-HSA-209560	0.559523	0.252	0	0
Collagen degradation	R-HSA-1442490	0.494857	0.306	0	0
Signaling by TGFB family members	R-HSA-9006936	0.307265	0.512	1	0
Cellular responses to stress	R-HSA-2262752	0.217402	0.663	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	0.251435	0.600	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	0.208502	0.681	0	0
HDMs demethylate histones	R-HSA-3214842	0.195814	0.708	0	0
Biotin transport and metabolism	R-HSA-196780	0.424153	0.372	0	0
Gastrulation	R-HSA-9758941	0.349710	0.456	0	0
Sema4D in semaphorin signaling	R-HSA-400685	0.542342	0.266	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	0.196774	0.706	0	0
Cell junction organization	R-HSA-446728	0.540288	0.267	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	0.216267	0.665	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	0.185359	0.732	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	0.297263	0.527	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	0.353144	0.452	0	0
FLT3 signaling in disease	R-HSA-9682385	0.450151	0.347	0	0
Cellular responses to stimuli	R-HSA-8953897	0.309704	0.509	0	0
ERK/MAPK targets	R-HSA-198753	0.228565	0.641	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	0.297404	0.527	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	0.161191	0.793	0	0
TBC/RABGAPs	R-HSA-8854214	0.309431	0.509	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	0.355182	0.450	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	0.584014	0.234	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	0.315231	0.501	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	0.190924	0.719	0	0
Formation of paraxial mesoderm	R-HSA-9793380	0.494857	0.306	0	0
Netrin-1 signaling	R-HSA-373752	0.327656	0.485	0	0
RMTs methylate histone arginines	R-HSA-3214858	0.474177	0.324	0	0
MAP kinase activation	R-HSA-450294	0.250796	0.601	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	0.274843	0.561	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	0.391034	0.408	0	0
p38MAPK events	R-HSA-171007	0.424153	0.372	0	0
Interleukin-17 signaling	R-HSA-448424	0.275442	0.560	0	0
Ub-specific processing proteases	R-HSA-5689880	0.610284	0.214	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	0.605044	0.218	0	0
Pyrimidine salvage	R-HSA-73614	0.614463	0.212	0	0
FLT3 Signaling	R-HSA-9607240	0.256277	0.591	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	0.434406	0.362	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	0.255112	0.593	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	0.605044	0.218	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	0.605044	0.218	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	0.380263	0.420	0	0
Post NMDA receptor activation events	R-HSA-438064	0.155421	0.808	0	0
Sensory processing of sound	R-HSA-9659379	0.526128	0.279	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	0.376651	0.424	0	0
Kidney development	R-HSA-9830369	0.339753	0.469	0	0
Semaphorin interactions	R-HSA-373755	0.528689	0.277	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	0.613388	0.212	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	0.279482	0.554	0	0
Breakdown of the nuclear lamina	R-HSA-352238	0.312879	0.505	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	0.126217	0.899	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	0.464977	0.333	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	0.323626	0.490	0	0
SLC-mediated bile acid transport	R-HSA-9958517	0.399818	0.398	0	0
Maturation of nucleoprotein	R-HSA-9683610	0.357453	0.447	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	0.391034	0.408	0	0
Sensory perception of sour taste	R-HSA-9729555	0.527897	0.277	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	0.456625	0.340	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	0.380263	0.420	0	0
Interleukin-36 pathway	R-HSA-9014826	0.583421	0.234	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	0.514093	0.289	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	0.627224	0.203	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	0.274843	0.561	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	0.279586	0.553	0	0
Signaling by PTK6	R-HSA-8848021	0.279586	0.553	0	0
Host Interactions of HIV factors	R-HSA-162909	0.212026	0.674	1	0
SARS-CoV-2-host interactions	R-HSA-9705683	0.453675	0.343	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	0.276175	0.559	0	0
Signaling by TGFBR3	R-HSA-9839373	0.239154	0.621	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	0.160626	0.794	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	0.144726	0.839	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	0.601483	0.221	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	0.310356	0.508	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	0.483478	0.316	0	0
DAG and IP3 signaling	R-HSA-1489509	0.346057	0.461	0	0
PECAM1 interactions	R-HSA-210990	0.522518	0.282	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	0.581894	0.235	0	0
Calmodulin induced events	R-HSA-111933	0.294782	0.530	0	0
Glycolysis	R-HSA-70171	0.163798	0.786	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	0.493798	0.306	0	0
NrCAM interactions	R-HSA-447038	0.218552	0.660	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	0.191317	0.718	0	0
Signaling by PDGFR in disease	R-HSA-9671555	0.126383	0.898	0	0
Anchoring fibril formation	R-HSA-2214320	0.289802	0.538	0	0
The NLRP1 inflammasome	R-HSA-844455	0.464977	0.333	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	0.527897	0.277	0	0
Dopamine receptors	R-HSA-390651	0.527897	0.277	0	0
CaM pathway	R-HSA-111997	0.294782	0.530	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	0.436652	0.360	0	0
Fibronectin matrix formation	R-HSA-1566977	0.488296	0.311	0	0
Bicarbonate transporters	R-HSA-425381	0.522518	0.282	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	0.408078	0.389	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	0.627224	0.203	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	0.256262	0.591	0	0
Interferon Signaling	R-HSA-913531	0.549460	0.260	0	0
Ca-dependent events	R-HSA-111996	0.434406	0.362	0	0
Maturation of nucleoprotein	R-HSA-9694631	0.577353	0.239	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	0.256262	0.591	0	0
Collagen chain trimerization	R-HSA-8948216	0.471726	0.326	0	0
tRNA processing	R-HSA-72306	0.497903	0.303	0	0
Glucose metabolism	R-HSA-70326	0.376664	0.424	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	0.146495	0.834	0	0
Formation of the nephric duct	R-HSA-9830364	0.347157	0.459	0	0
IRE1alpha activates chaperones	R-HSA-381070	0.204187	0.690	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	0.548751	0.261	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	0.622802	0.206	0	0
Interleukin-7 signaling	R-HSA-1266695	0.542342	0.266	0	0
Signaling by Leptin	R-HSA-2586552	0.483478	0.316	0	0
Lagging Strand Synthesis	R-HSA-69186	0.631012	0.200	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	0.631012	0.200	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	0.631012	0.200	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	0.631451	0.200	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	0.632418	0.199	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	0.632418	0.199	0	0
PDE3B signalling	R-HSA-165160	0.632418	0.199	0	0
PKB-mediated events	R-HSA-109703	0.632418	0.199	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	0.632418	0.199	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	0.632418	0.199	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	0.632418	0.199	0	0
Signaling by MAPK mutants	R-HSA-9652817	0.632418	0.199	0	0
Signaling by RNF43 mutants	R-HSA-5340588	0.632418	0.199	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	0.632418	0.199	0	0
TRAIL signaling	R-HSA-75158	0.632418	0.199	0	0
Synthesis of dolichyl-phosphate mannose	R-HSA-162699	0.632418	0.199	0	0
Sensory perception of salty taste	R-HSA-9730628	0.632418	0.199	0	0
Synthesis of PS	R-HSA-1483101	0.632418	0.199	0	0
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	0.632418	0.199	0	0
VEGF ligand-receptor interactions	R-HSA-194313	0.632418	0.199	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	0.632418	0.199	0	0
Relaxin receptors	R-HSA-444821	0.632418	0.199	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	0.632418	0.199	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	0.632418	0.199	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	0.632418	0.199	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	0.634049	0.198	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	0.634049	0.198	0	0
mRNA Capping	R-HSA-72086	0.636870	0.196	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	0.636870	0.196	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	0.636870	0.196	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	0.636870	0.196	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	0.637645	0.195	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	0.639698	0.194	0	0
NCAM1 interactions	R-HSA-419037	0.643281	0.192	0	0
Cell-Cell communication	R-HSA-1500931	0.645094	0.190	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	0.647098	0.189	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	0.647098	0.189	0	0
DNA Replication	R-HSA-69306	0.648090	0.188	0	0
Collagen formation	R-HSA-1474290	0.648232	0.188	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	0.648232	0.188	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	0.649766	0.187	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	0.654101	0.184	0	0
Regulation of mitotic cell cycle	R-HSA-453276	0.654101	0.184	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	0.654101	0.184	0	0
PI Metabolism	R-HSA-1483255	0.655220	0.184	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	0.656005	0.183	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	0.656005	0.183	0	0
Assembly Of The HIV Virion	R-HSA-175474	0.656005	0.183	0	0
L1CAM interactions	R-HSA-373760	0.656995	0.182	0	0
Removal of the Flap Intermediate	R-HSA-69166	0.657916	0.182	0	0
cGMP effects	R-HSA-418457	0.657916	0.182	0	0
Retrograde neurotrophin signalling	R-HSA-177504	0.657916	0.182	0	0
Physiological factors	R-HSA-5578768	0.657916	0.182	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	0.657916	0.182	0	0
Signaling by FGFR2	R-HSA-5654738	0.660752	0.180	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	0.660752	0.180	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	0.661855	0.179	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	0.661855	0.179	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	0.662440	0.179	0	0
Diseases of programmed cell death	R-HSA-9645723	0.667093	0.176	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	0.667149	0.176	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	0.667149	0.176	0	0
Diseases of DNA repair	R-HSA-9675135	0.667149	0.176	0	0
PPARA activates gene expression	R-HSA-1989781	0.667740	0.175	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	0.668371	0.175	0	0
STAT5 Activation	R-HSA-9645135	0.675654	0.170	0	0
Erythropoietin activates STAT5	R-HSA-9027283	0.675654	0.170	0	0
Autointegration results in viral DNA circles	R-HSA-177539	0.675654	0.170	0	0
Metabolism of ingested MeSeO2H into MeSeH	R-HSA-5263617	0.675654	0.170	0	0
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	0.675654	0.170	0	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	0.675654	0.170	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	0.675654	0.170	0	0
Intracellular metabolism of fatty acids regulates insulin secretion	R-HSA-434313	0.675654	0.170	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	0.675654	0.170	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	0.675654	0.170	0	0
NADPH regeneration	R-HSA-389542	0.675654	0.170	0	0
HDL clearance	R-HSA-8964011	0.675654	0.170	0	0
Nef and signal transduction	R-HSA-164944	0.675654	0.170	0	0
Neurofascin interactions	R-HSA-447043	0.675654	0.170	0	0
Defective factor VIII causes hemophilia A	R-HSA-9662001	0.675654	0.170	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	0.678966	0.168	0	0
Budding and maturation of HIV virion	R-HSA-162588	0.679073	0.168	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	0.679073	0.168	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	0.679756	0.168	0	0
Ca2+ pathway	R-HSA-4086398	0.682288	0.166	0	0
Recycling pathway of L1	R-HSA-437239	0.683976	0.165	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	0.686549	0.163	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	0.686549	0.163	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	0.686549	0.163	0	0
SHC1 events in EGFR signaling	R-HSA-180336	0.686549	0.163	0	0
FGFR3 ligand binding and activation	R-HSA-190239	0.686549	0.163	0	0
Spry regulation of FGF signaling	R-HSA-1295596	0.686549	0.163	0	0
DNA Damage Reversal	R-HSA-73942	0.686549	0.163	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	0.686549	0.163	0	0
Protein methylation	R-HSA-8876725	0.686549	0.163	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	0.686796	0.163	0	0
HCMV Late Events	R-HSA-9610379	0.686796	0.163	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	0.687659	0.163	0	0
Cellular response to hypoxia	R-HSA-1234174	0.691668	0.160	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	0.691668	0.160	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	0.695559	0.158	0	0
Signaling by FGFR in disease	R-HSA-1226099	0.695842	0.157	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	0.698703	0.156	0	0
Aggrephagy	R-HSA-9646399	0.698703	0.156	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	0.698703	0.156	0	0
Interleukin-2 family signaling	R-HSA-451927	0.698703	0.156	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	0.702266	0.153	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	0.702266	0.153	0	0
Carnitine shuttle	R-HSA-200425	0.702266	0.153	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	0.702266	0.153	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	0.702266	0.153	0	0
Formation of the ureteric bud	R-HSA-9830674	0.702266	0.153	0	0
Growth hormone receptor signaling	R-HSA-982772	0.702266	0.153	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	0.706339	0.151	0	0
Signaling by FGFR	R-HSA-190236	0.708571	0.150	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	0.713180	0.147	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	0.713180	0.147	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	0.713180	0.147	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	0.713180	0.147	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	0.713807	0.146	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	0.713807	0.146	0	0
Glycoprotein hormones	R-HSA-209822	0.713807	0.146	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	0.713807	0.146	0	0
FGFR3b ligand binding and activation	R-HSA-190371	0.713807	0.146	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	0.713807	0.146	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	0.713807	0.146	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	0.713807	0.146	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	0.713807	0.146	0	0
VLDL clearance	R-HSA-8964046	0.713807	0.146	0	0
Ca2+ activated K+ channels	R-HSA-1296052	0.713807	0.146	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	0.713807	0.146	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	0.713807	0.146	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	0.713807	0.146	0	0
DNA Damage Bypass	R-HSA-73893	0.715925	0.145	0	0
Dual incision in TC-NER	R-HSA-6782135	0.717254	0.144	0	0
Integrin signaling	R-HSA-354192	0.717724	0.144	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	0.718761	0.143	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	0.723548	0.141	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	0.723548	0.141	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	0.723548	0.141	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	0.723548	0.141	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	0.724661	0.140	0	0
Signaling by Insulin receptor	R-HSA-74752	0.727674	0.138	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	0.730845	0.136	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	0.732181	0.135	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	0.732181	0.135	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	0.732181	0.135	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	0.732501	0.135	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	0.734014	0.134	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	0.735715	0.133	0	0
Assembly of the pre-replicative complex	R-HSA-68867	0.738881	0.131	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	0.738975	0.131	0	0
Influenza Infection	R-HSA-168255	0.739324	0.131	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	0.743622	0.129	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	0.743622	0.129	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	0.743622	0.129	0	0
Tight junction interactions	R-HSA-420029	0.743622	0.129	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	0.744252	0.128	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	0.745258	0.128	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	0.746327	0.127	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	0.747019	0.127	0	0
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	0.747473	0.126	0	0
Regulation by c-FLIP	R-HSA-3371378	0.747473	0.126	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	0.747473	0.126	0	0
Dimerization of procaspase-8	R-HSA-69416	0.747473	0.126	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	0.747473	0.126	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	0.747473	0.126	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	0.747473	0.126	0	0
Fructose biosynthesis	R-HSA-5652227	0.747473	0.126	0	0
Formation of annular gap junctions	R-HSA-196025	0.747473	0.126	0	0
TGFBR3 PTM regulation	R-HSA-9839383	0.747473	0.126	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	0.747473	0.126	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	0.747873	0.126	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	0.752827	0.123	0	0
Dual Incision in GG-NER	R-HSA-5696400	0.752827	0.123	0	0
Mitophagy	R-HSA-5205647	0.752827	0.123	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	0.752827	0.123	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	0.752827	0.123	0	0
PLC beta mediated events	R-HSA-112043	0.757973	0.120	0	0
Orc1 removal from chromatin	R-HSA-68949	0.759532	0.119	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	0.759532	0.119	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	0.759696	0.119	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	0.759696	0.119	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	0.760751	0.119	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	0.760751	0.119	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	0.760751	0.119	0	0
MET activates PTK2 signaling	R-HSA-8874081	0.762516	0.118	0	0
Attachment of bacteria to epithelial cells	R-HSA-9638630	0.762516	0.118	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	0.762516	0.118	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	0.762516	0.118	0	0
HCMV Infection	R-HSA-9609646	0.766797	0.115	0	0
Co-inhibition by PD-1	R-HSA-389948	0.768792	0.114	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	0.769484	0.114	0	0
Meiotic synapsis	R-HSA-1221632	0.772920	0.112	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	0.772920	0.112	0	0
Smooth Muscle Contraction	R-HSA-445355	0.772920	0.112	0	0
Cellular response to chemical stress	R-HSA-9711123	0.772984	0.112	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	0.773383	0.112	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	0.773383	0.112	0	0
CASP8 activity is inhibited	R-HSA-5218900	0.777182	0.109	0	0
Gap junction degradation	R-HSA-190873	0.777182	0.109	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	0.777182	0.109	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	0.777182	0.109	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	0.777182	0.109	0	0
ARMS-mediated activation	R-HSA-170984	0.777182	0.109	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	0.777182	0.109	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	0.777182	0.109	0	0
Lipophagy	R-HSA-9613354	0.777182	0.109	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	0.777182	0.109	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	0.777182	0.109	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	0.777182	0.109	0	0
EPHB-mediated forward signaling	R-HSA-3928662	0.777186	0.109	0	0
DAP12 interactions	R-HSA-2172127	0.777186	0.109	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	0.780263	0.108	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	0.780263	0.108	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	0.780263	0.108	0	0
Insulin processing	R-HSA-264876	0.780263	0.108	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	0.780263	0.108	0	0
Maturation of hRSV A proteins	R-HSA-9828806	0.780263	0.108	0	0
GAB1 signalosome	R-HSA-180292	0.781865	0.107	0	0
Ephrin signaling	R-HSA-3928664	0.781865	0.107	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	0.781865	0.107	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	0.781865	0.107	0	0
Tie2 Signaling	R-HSA-210993	0.781865	0.107	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	0.782668	0.106	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	0.782710	0.106	1	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	0.785742	0.105	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	0.788907	0.103	0	0
Base Excision Repair	R-HSA-73884	0.790208	0.102	0	0
Nucleosome assembly	R-HSA-774815	0.790827	0.102	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	0.790827	0.102	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	0.790827	0.102	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	0.796901	0.099	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	0.796901	0.099	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	0.798006	0.098	0	0
Degradation of AXIN	R-HSA-4641257	0.799036	0.097	0	0
Voltage gated Potassium channels	R-HSA-1296072	0.799036	0.097	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	0.799036	0.097	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	0.801325	0.096	0	0
Regulation of signaling by CBL	R-HSA-912631	0.801325	0.096	0	0
Translesion Synthesis by POLH	R-HSA-110320	0.801325	0.096	0	0
Rap1 signalling	R-HSA-392517	0.801325	0.096	0	0
Specification of the neural plate border	R-HSA-9834899	0.801325	0.096	0	0
STING mediated induction of host immune responses	R-HSA-1834941	0.801325	0.096	0	0
Diseases of hemostasis	R-HSA-9671793	0.801325	0.096	0	0
Other interleukin signaling	R-HSA-449836	0.801325	0.096	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	0.803396	0.095	0	0
Folding of actin by CCT/TriC	R-HSA-390450	0.803396	0.095	0	0
Peptide hormone biosynthesis	R-HSA-209952	0.803396	0.095	0	0
DNA replication initiation	R-HSA-68952	0.803396	0.095	0	0
Interleukin-27 signaling	R-HSA-9020956	0.803396	0.095	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	0.803396	0.095	0	0
2-LTR circle formation	R-HSA-164843	0.803396	0.095	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	0.803396	0.095	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	0.803396	0.095	0	0
Josephin domain DUBs	R-HSA-5689877	0.803396	0.095	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	0.803396	0.095	0	0
DNA methylation	R-HSA-5334118	0.812472	0.090	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	0.812472	0.090	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	0.812472	0.090	0	0
DARPP-32 events	R-HSA-180024	0.812472	0.090	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	0.812797	0.090	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	0.812797	0.090	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	0.816794	0.088	0	0
Hedgehog 'off' state	R-HSA-5610787	0.817336	0.088	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	0.819226	0.087	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	0.819226	0.087	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	0.819226	0.087	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	0.819226	0.087	0	0
Pregnenolone biosynthesis	R-HSA-196108	0.819226	0.087	0	0
Nephrin family interactions	R-HSA-373753	0.819226	0.087	0	0
Protein hydroxylation	R-HSA-9629569	0.819226	0.087	0	0
Signal transduction by L1	R-HSA-445144	0.819226	0.087	0	0
Interleukin-12 signaling	R-HSA-9020591	0.822643	0.085	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	0.825719	0.083	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	0.825775	0.083	0	0
G-protein mediated events	R-HSA-112040	0.826325	0.083	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	0.826528	0.083	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	0.826528	0.083	0	0
Formation of the posterior neural plate	R-HSA-9832991	0.826528	0.083	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	0.826528	0.083	0	0
vRNA Synthesis	R-HSA-192814	0.826528	0.083	0	0
Hormone ligand-binding receptors	R-HSA-375281	0.826528	0.083	0	0
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	0.826528	0.083	0	0
Synthesis of PI	R-HSA-1483226	0.826528	0.083	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	0.826528	0.083	0	0
Chylomicron assembly	R-HSA-8963888	0.826528	0.083	0	0
Suppression of apoptosis	R-HSA-9635465	0.826528	0.083	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	0.833888	0.079	0	0
Adherens junctions interactions	R-HSA-418990	0.834497	0.079	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	0.835667	0.078	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	0.835667	0.078	0	0
Basigin interactions	R-HSA-210991	0.835667	0.078	0	0
SARS-CoV-2 Infection	R-HSA-9694516	0.839102	0.076	0	0
Interferon gamma signaling	R-HSA-877300	0.839458	0.076	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	0.840588	0.075	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	0.843609	0.074	0	0
Interleukin-12 family signaling	R-HSA-447115	0.846194	0.073	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	0.846626	0.072	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	0.846626	0.072	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	0.846940	0.072	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	0.846940	0.072	0	0
ERKs are inactivated	R-HSA-202670	0.846940	0.072	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	0.846940	0.072	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	0.846940	0.072	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	0.846940	0.072	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	0.846940	0.072	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	0.846940	0.072	0	0
DS-GAG biosynthesis	R-HSA-2022923	0.846940	0.072	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	0.849428	0.071	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	0.849494	0.071	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	0.849494	0.071	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	0.854301	0.068	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	0.858846	0.066	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	0.859350	0.066	0	0
HSF1-dependent transactivation	R-HSA-3371571	0.859350	0.066	0	0
Chromosome Maintenance	R-HSA-73886	0.860126	0.065	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	0.860292	0.065	0	0
Signaling by KIT in disease	R-HSA-9669938	0.864548	0.063	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	0.864548	0.063	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	0.864548	0.063	0	0
FGFR2 alternative splicing	R-HSA-6803529	0.864548	0.063	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	0.864548	0.063	0	0
Fructose metabolism	R-HSA-5652084	0.864548	0.063	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	0.864548	0.063	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	0.864950	0.063	0	0
IRAK1 recruits IKK complex	R-HSA-937039	0.864950	0.063	0	0
GRB2 events in EGFR signaling	R-HSA-179812	0.864950	0.063	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	0.864950	0.063	0	0
Interleukin-35 Signalling	R-HSA-8984722	0.864950	0.063	0	0
Leading Strand Synthesis	R-HSA-69109	0.864950	0.063	0	0
Polymerase switching	R-HSA-69091	0.864950	0.063	0	0
Estrogen biosynthesis	R-HSA-193144	0.864950	0.063	0	0
OAS antiviral response	R-HSA-8983711	0.864950	0.063	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	0.864980	0.063	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	0.864980	0.063	0	0
Regulation of necroptotic cell death	R-HSA-5675482	0.864980	0.063	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	0.866519	0.062	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	0.866519	0.062	0	0
Cell-cell junction organization	R-HSA-421270	0.867758	0.062	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	0.868719	0.061	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	0.868719	0.061	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	0.868719	0.061	0	0
Signaling by PDGF	R-HSA-186797	0.869146	0.061	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	0.870420	0.060	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	0.873301	0.059	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	0.875897	0.058	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	0.877172	0.057	0	0
Syndecan interactions	R-HSA-3000170	0.877172	0.057	0	0
Mitochondrial mRNA modification	R-HSA-9937008	0.877172	0.057	0	0
Cytoprotection by HMOX1	R-HSA-9707564	0.880468	0.055	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	0.880843	0.055	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	0.880843	0.055	0	0
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	0.880843	0.055	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	0.880843	0.055	0	0
Processing of SMDT1	R-HSA-8949664	0.880843	0.055	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	0.880843	0.055	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	0.882849	0.054	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	0.884248	0.053	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	0.885158	0.053	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	0.885879	0.053	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	0.886023	0.053	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	0.886023	0.053	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	0.886023	0.053	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	0.886023	0.053	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	0.886023	0.053	0	0
Cap-dependent Translation Initiation	R-HSA-72737	0.886317	0.052	0	0
Eukaryotic Translation Initiation	R-HSA-72613	0.886317	0.052	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	0.888701	0.051	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	0.888701	0.051	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	0.888701	0.051	0	0
Mitochondrial RNA degradation	R-HSA-9836573	0.888701	0.051	0	0
Plasma lipoprotein assembly	R-HSA-8963898	0.888701	0.051	0	0
Rab regulation of trafficking	R-HSA-9007101	0.891905	0.050	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	0.892710	0.049	0	0
Meiosis	R-HSA-1500620	0.893797	0.049	0	0
FGFR3c ligand binding and activation	R-HSA-190372	0.894866	0.048	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	0.894866	0.048	0	0
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	0.894866	0.048	0	0
HDL assembly	R-HSA-8963896	0.894866	0.048	0	0
Signal regulatory protein family interactions	R-HSA-391160	0.894866	0.048	0	0
P2Y receptors	R-HSA-417957	0.894866	0.048	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	0.894866	0.048	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	0.895404	0.048	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	0.895404	0.048	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	0.895404	0.048	0	0
Fanconi Anemia Pathway	R-HSA-6783310	0.897089	0.047	0	0
Somitogenesis	R-HSA-9824272	0.897089	0.047	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	0.897089	0.047	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	0.899219	0.046	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	0.899219	0.046	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	0.899219	0.046	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	0.899219	0.046	0	0
Interleukin-1 family signaling	R-HSA-446652	0.900102	0.046	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	0.904085	0.044	0	0
GPVI-mediated activation cascade	R-HSA-114604	0.904085	0.044	0	0
Triglyceride catabolism	R-HSA-163560	0.904085	0.044	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	0.904838	0.043	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	0.904838	0.043	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	0.907239	0.042	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	0.907239	0.042	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	0.907239	0.042	0	0
Signaling by Activin	R-HSA-1502540	0.907239	0.042	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	0.907239	0.042	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	0.907239	0.042	0	0
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	0.907239	0.042	0	0
Formation of the anterior neural plate	R-HSA-9823739	0.907239	0.042	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	0.907239	0.042	0	0
Other semaphorin interactions	R-HSA-416700	0.907239	0.042	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	0.908804	0.042	0	0
Metalloprotease DUBs	R-HSA-5689901	0.908804	0.042	0	0
TRP channels	R-HSA-3295583	0.908804	0.042	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	0.908804	0.042	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	0.912066	0.040	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	0.912109	0.040	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	0.912109	0.040	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	0.912112	0.040	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	0.912169	0.040	0	0
RSV-host interactions	R-HSA-9833110	0.913339	0.039	0	0
Signaling by Hedgehog	R-HSA-5358351	0.916362	0.038	0	0
Packaging Of Telomere Ends	R-HSA-171306	0.917529	0.037	0	0
Cristae formation	R-HSA-8949613	0.917529	0.037	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	0.917529	0.037	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	0.917529	0.037	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	0.918157	0.037	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	0.918157	0.037	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	0.918157	0.037	0	0
Activation of SMO	R-HSA-5635838	0.918157	0.037	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	0.918157	0.037	0	0
Fructose catabolism	R-HSA-70350	0.918157	0.037	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	0.918157	0.037	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	0.918157	0.037	0	0
Mineralocorticoid biosynthesis	R-HSA-193993	0.918157	0.037	0	0
Attachment and Entry	R-HSA-9678110	0.918157	0.037	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	0.919517	0.036	0	0
Biofilm formation	R-HSA-9931953	0.919517	0.036	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	0.920137	0.036	0	0
Extension of Telomeres	R-HSA-180786	0.920569	0.036	0	0
MHC class II antigen presentation	R-HSA-2132295	0.920887	0.036	0	0
Telomere Maintenance	R-HSA-157579	0.921978	0.035	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	0.925069	0.034	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	0.925069	0.034	0	0
Degradation of CDH1	R-HSA-9766229	0.925069	0.034	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	0.925464	0.034	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	0.925464	0.034	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	0.926351	0.033	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	0.927790	0.033	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	0.927790	0.033	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	0.927790	0.033	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	0.927790	0.033	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	0.927790	0.033	0	0
Synthesis of PG	R-HSA-1483148	0.927790	0.033	0	0
Galactose catabolism	R-HSA-70370	0.927790	0.033	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	0.927790	0.033	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	0.927790	0.033	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	0.927790	0.033	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	0.928737	0.032	0	0
Hedgehog 'on' state	R-HSA-5632684	0.928737	0.032	0	0
ECM proteoglycans	R-HSA-3000178	0.928737	0.032	0	0
Stimuli-sensing channels	R-HSA-2672351	0.931141	0.031	0	0
Aquaporin-mediated transport	R-HSA-445717	0.931597	0.031	0	0
Generation of second messenger molecules	R-HSA-202433	0.932649	0.030	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	0.932649	0.030	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	0.932675	0.030	0	0
Regulation of gene expression in beta cells	R-HSA-210745	0.932675	0.030	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	0.932675	0.030	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	0.936290	0.029	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	0.936290	0.029	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	0.936290	0.029	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	0.936290	0.029	0	0
Catecholamine biosynthesis	R-HSA-209905	0.936290	0.029	0	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	0.936290	0.029	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	0.936290	0.029	0	0
Glycogen storage diseases	R-HSA-3229121	0.936290	0.029	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	0.936290	0.029	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	0.936441	0.029	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	0.939221	0.027	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	0.941237	0.026	0	0
Complex I biogenesis	R-HSA-6799198	0.941237	0.026	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	0.941343	0.026	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	0.941343	0.026	0	0
Toll-like Receptor Cascades	R-HSA-168898	0.942517	0.026	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	0.943779	0.025	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	0.943779	0.025	0	0
Scavenging by Class A Receptors	R-HSA-3000480	0.943779	0.025	0	0
Translation of Structural Proteins	R-HSA-9683701	0.943779	0.025	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	0.943790	0.025	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	0.943790	0.025	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	0.943790	0.025	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	0.943790	0.025	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	0.943790	0.025	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	0.943790	0.025	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	0.943790	0.025	0	0
Trafficking of AMPA receptors	R-HSA-399719	0.945160	0.024	0	0
Downstream signal transduction	R-HSA-186763	0.945160	0.024	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	0.946006	0.024	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	0.948067	0.023	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	0.948680	0.023	0	0
Depyrimidination	R-HSA-73928	0.948680	0.023	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	0.949273	0.023	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	0.950408	0.022	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	0.950408	0.022	0	0
HDL remodeling	R-HSA-8964058	0.950408	0.022	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	0.950408	0.022	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	0.950408	0.022	0	0
DAG1 glycosylations	R-HSA-8931838	0.950543	0.022	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	0.950543	0.022	0	0
Signaling by Interleukins	R-HSA-449147	0.951024	0.022	0	0
Reproduction	R-HSA-1474165	0.951907	0.021	0	0
Defective pyroptosis	R-HSA-9710421	0.953180	0.021	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	0.953180	0.021	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	0.953313	0.021	0	0
Cellular response to starvation	R-HSA-9711097	0.953419	0.021	0	0
G alpha (z) signalling events	R-HSA-418597	0.954329	0.020	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	0.955419	0.020	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	0.955419	0.020	0	0
Recycling of bile acids and salts	R-HSA-159418	0.955419	0.020	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	0.956246	0.019	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	0.956246	0.019	0	0
Signaling by NODAL	R-HSA-1181150	0.956246	0.019	0	0
Creatine metabolism	R-HSA-71288	0.956246	0.019	0	0
Glycogen synthesis	R-HSA-3322077	0.956246	0.019	0	0
Cholesterol biosynthesis	R-HSA-191273	0.957026	0.019	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	0.957138	0.019	0	0
Amine ligand-binding receptors	R-HSA-375280	0.957310	0.019	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	0.958031	0.019	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	0.958117	0.019	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	0.959450	0.018	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	0.961095	0.017	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	0.961095	0.017	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	0.961398	0.017	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	0.961398	0.017	0	0
Regulation of CDH1 Function	R-HSA-9764561	0.961455	0.017	0	0
PKR-mediated signaling	R-HSA-9833482	0.962984	0.016	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	0.963222	0.016	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	0.963826	0.016	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	0.963826	0.016	0	0
Hyaluronan metabolism	R-HSA-2142845	0.963826	0.016	0	0
Serine metabolism	R-HSA-977347	0.965943	0.015	0	0
Glutathione synthesis and recycling	R-HSA-174403	0.965943	0.015	0	0
Androgen biosynthesis	R-HSA-193048	0.965943	0.015	0	0
Attachment and Entry	R-HSA-9694614	0.965943	0.015	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	0.967740	0.014	0	0
Synthesis of PC	R-HSA-1483191	0.967740	0.014	0	0
Integration of energy metabolism	R-HSA-163685	0.968079	0.014	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	0.968335	0.014	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	0.968488	0.014	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	0.969953	0.013	0	0
Reactions specific to the complex N-glycan synthesis pathway	R-HSA-975578	0.969953	0.013	0	0
Ethanol oxidation	R-HSA-71384	0.969953	0.013	0	0
LDL clearance	R-HSA-8964038	0.969953	0.013	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	0.969953	0.013	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	0.970231	0.013	0	0
Glutathione conjugation	R-HSA-156590	0.970231	0.013	0	0
EPH-Ephrin signaling	R-HSA-2682334	0.970551	0.013	0	0
Co-stimulation by CD28	R-HSA-389356	0.970645	0.013	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	0.970645	0.013	0	0
HSF1 activation	R-HSA-3371511	0.970698	0.013	0	0
Glycosphingolipid transport	R-HSA-9845576	0.970698	0.013	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	0.971134	0.013	0	0
SLC transporter disorders	R-HSA-5619102	0.971435	0.013	0	0
Nucleotide salvage	R-HSA-8956321	0.972714	0.012	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	0.973394	0.012	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	0.973492	0.012	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	0.973492	0.012	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	0.973643	0.012	0	0
Cleavage of the damaged purine	R-HSA-110331	0.973643	0.012	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	0.974683	0.011	0	0
Opioid Signalling	R-HSA-111885	0.974815	0.011	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	0.975003	0.011	0	0
Regulation of RAS by GAPs	R-HSA-5658442	0.975728	0.011	0	0
Potential therapeutics for SARS	R-HSA-9679191	0.976130	0.010	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	0.976301	0.010	0	0
tRNA processing in the mitochondrion	R-HSA-6785470	0.976301	0.010	0	0
Depurination	R-HSA-73927	0.976301	0.010	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	0.976376	0.010	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	0.976613	0.010	0	0
TNFs bind their physiological receptors	R-HSA-5669034	0.976613	0.010	0	0
Protein ubiquitination	R-HSA-8852135	0.977428	0.010	0	0
Meiotic recombination	R-HSA-912446	0.977945	0.010	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	0.977945	0.010	0	0
Stabilization of p53	R-HSA-69541	0.978699	0.009	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	0.978699	0.009	0	0
Plasma lipoprotein clearance	R-HSA-8964043	0.978699	0.009	0	0
Acyl chain remodelling of PS	R-HSA-1482801	0.979368	0.009	0	0
Defects in cobalamin (B12) metabolism	R-HSA-3296469	0.979368	0.009	0	0
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	0.979368	0.009	0	0
Hyaluronan degradation	R-HSA-2160916	0.979368	0.009	0	0
SARS-CoV Infections	R-HSA-9679506	0.979638	0.009	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	0.979648	0.009	0	0
Potassium Channels	R-HSA-1296071	0.979648	0.009	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	0.979654	0.009	0	0
Chaperonin-mediated protein folding	R-HSA-390466	0.980009	0.009	0	0
Attenuation phase	R-HSA-3371568	0.980861	0.008	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	0.980861	0.008	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	0.980861	0.008	0	0
Translation of Structural Proteins	R-HSA-9694635	0.980885	0.008	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	0.981070	0.008	0	0
Membrane Trafficking	R-HSA-199991	0.981643	0.008	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	0.981798	0.008	0	0
Suppression of phagosomal maturation	R-HSA-9637687	0.981798	0.008	0	0
Urea cycle	R-HSA-70635	0.981798	0.008	0	0
Sphingolipid catabolism	R-HSA-9845614	0.981798	0.008	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	0.981812	0.008	0	0
Integrin cell surface interactions	R-HSA-216083	0.982421	0.008	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	0.982472	0.008	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	0.982809	0.008	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	0.982809	0.008	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	0.982809	0.008	0	0
Maturation of spike protein	R-HSA-9694548	0.982809	0.008	0	0
SARS-CoV-1 Infection	R-HSA-9678108	0.982950	0.007	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	0.983306	0.007	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	0.983494	0.007	0	0
Cobalamin (Cbl) metabolism	R-HSA-9759218	0.983942	0.007	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	0.983942	0.007	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	0.983942	0.007	0	0
Signaling by BMP	R-HSA-201451	0.983942	0.007	0	0
Synthesis of PE	R-HSA-1483213	0.983942	0.007	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	0.983942	0.007	0	0
Metabolism of steroid hormones	R-HSA-196071	0.983978	0.007	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	0.984564	0.007	0	0
Intra-Golgi traffic	R-HSA-6811438	0.984564	0.007	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	0.984564	0.007	0	0
Regulated Necrosis	R-HSA-5218859	0.985360	0.006	0	0
Telomere Extension By Telomerase	R-HSA-171319	0.985833	0.006	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	0.985833	0.006	0	0
Pyroptosis	R-HSA-5620971	0.985833	0.006	0	0
Inflammasomes	R-HSA-622312	0.985833	0.006	0	0
Interleukin-1 signaling	R-HSA-9020702	0.986080	0.006	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	0.986080	0.006	0	0
Activation of GABAB receptors	R-HSA-991365	0.986144	0.006	0	0
GABA B receptor activation	R-HSA-977444	0.986144	0.006	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	0.986144	0.006	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	0.987502	0.005	0	0
Thyroxine biosynthesis	R-HSA-209968	0.987502	0.005	0	0
Platelet calcium homeostasis	R-HSA-418360	0.987502	0.005	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	0.987567	0.005	0	0
Pyrimidine catabolism	R-HSA-73621	0.987567	0.005	0	0
Protein folding	R-HSA-391251	0.987633	0.005	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	0.987633	0.005	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	0.987633	0.005	0	0
COPII-mediated vesicle transport	R-HSA-204005	0.987793	0.005	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	0.987793	0.005	0	0
Degradation of the extracellular matrix	R-HSA-1474228	0.988644	0.005	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	0.988846	0.005	0	0
Proteasome assembly	R-HSA-9907900	0.988846	0.005	0	0
Surfactant metabolism	R-HSA-5683826	0.988846	0.005	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	0.988847	0.005	0	0
Neurotransmitter clearance	R-HSA-112311	0.988975	0.005	0	0
Formation of the cornified envelope	R-HSA-6809371	0.989388	0.005	0	0
Mitochondrial protein degradation	R-HSA-9837999	0.989496	0.005	0	0
Peroxisomal protein import	R-HSA-9033241	0.989897	0.004	0	0
Triglyceride metabolism	R-HSA-8979227	0.989897	0.004	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	0.989997	0.004	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	0.989997	0.004	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	0.989997	0.004	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	0.990274	0.004	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	0.990274	0.004	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	0.990274	0.004	0	0
Molecules associated with elastic fibres	R-HSA-2129379	0.990274	0.004	0	0
Cargo concentration in the ER	R-HSA-5694530	0.990274	0.004	0	0
tRNA Aminoacylation	R-HSA-379724	0.990852	0.004	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	0.990976	0.004	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	0.991138	0.004	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	0.991420	0.004	0	0
Endogenous sterols	R-HSA-211976	0.991719	0.004	0	0
COPI-mediated anterograde transport	R-HSA-6807878	0.991801	0.004	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	0.991961	0.004	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	0.992431	0.003	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	0.992431	0.003	0	0
Mitochondrial protein import	R-HSA-1268020	0.992507	0.003	0	0
Intraflagellar transport	R-HSA-5620924	0.992796	0.003	0	0
Regulation of insulin secretion	R-HSA-422356	0.993062	0.003	0	0
Ribosome-associated quality control	R-HSA-9948299	0.993085	0.003	0	0
Peptide chain elongation	R-HSA-156902	0.993188	0.003	0	0
Striated Muscle Contraction	R-HSA-390522	0.993323	0.003	0	0
Acyl chain remodelling of PC	R-HSA-1482788	0.993323	0.003	0	0
Vpu mediated degradation of CD4	R-HSA-180534	0.993323	0.003	0	0
Heme degradation	R-HSA-189483	0.993323	0.003	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	0.993323	0.003	0	0
Miscellaneous transport and binding events	R-HSA-5223345	0.993323	0.003	0	0
Gap junction trafficking and regulation	R-HSA-157858	0.993546	0.003	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	0.993546	0.003	0	0
rRNA processing	R-HSA-72312	0.993784	0.003	0	0
G alpha (s) signalling events	R-HSA-418555	0.994097	0.003	0	0
eNOS activation	R-HSA-203615	0.994109	0.003	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	0.994109	0.003	0	0
RA biosynthesis pathway	R-HSA-5365859	0.994109	0.003	0	0
Calnexin/calreticulin cycle	R-HSA-901042	0.994109	0.003	0	0
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	0.994109	0.003	0	0
Azathioprine ADME	R-HSA-9748787	0.994220	0.003	0	0
Neurotransmitter release cycle	R-HSA-112310	0.994294	0.002	0	0
FCERI mediated MAPK activation	R-HSA-2871796	0.994617	0.002	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	0.994710	0.002	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	0.994780	0.002	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	0.994804	0.002	0	0
Acyl chain remodelling of PE	R-HSA-1482839	0.994804	0.002	0	0
Regulation of Apoptosis	R-HSA-169911	0.994804	0.002	0	0
Transferrin endocytosis and recycling	R-HSA-917977	0.994804	0.002	0	0
PERK regulates gene expression	R-HSA-381042	0.994804	0.002	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	0.995416	0.002	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	0.995416	0.002	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	0.995416	0.002	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	0.995476	0.002	0	0
Nicotinate metabolism	R-HSA-196807	0.995476	0.002	0	0
Eukaryotic Translation Elongation	R-HSA-156842	0.995636	0.002	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	0.995829	0.002	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	0.995914	0.002	0	0
Degradation of DVL	R-HSA-4641258	0.995956	0.002	0	0
SLC-mediated transport of organic cations	R-HSA-549127	0.995956	0.002	0	0
Metabolism of folate and pterines	R-HSA-196757	0.995956	0.002	0	0
Neuronal System	R-HSA-112316	0.996379	0.002	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	0.996383	0.002	0	0
Interferon alpha/beta signaling	R-HSA-909733	0.996428	0.002	0	0
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	0.996433	0.002	0	0
Elastic fibre formation	R-HSA-1566948	0.996433	0.002	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	0.996669	0.001	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	0.996680	0.001	0	0
Platelet degranulation	R-HSA-114608	0.996729	0.001	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	0.996853	0.001	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	0.996853	0.001	0	0
RAS processing	R-HSA-9648002	0.996853	0.001	0	0
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	0.996853	0.001	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	0.996962	0.001	0	0
Eukaryotic Translation Termination	R-HSA-72764	0.996962	0.001	0	0
Retinoid metabolism and transport	R-HSA-975634	0.996994	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	0.996994	0.001	0	0
Metabolism of amine-derived hormones	R-HSA-209776	0.997030	0.001	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	0.997224	0.001	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	0.997224	0.001	0	0
Glycogen metabolism	R-HSA-8982491	0.997224	0.001	0	0
N-glycan antennae elongation in the medial/trans-Golgi	R-HSA-975576	0.997224	0.001	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	0.997234	0.001	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	0.997288	0.001	0	0
Synthesis of PA	R-HSA-1483166	0.997344	0.001	0	0
Dectin-2 family	R-HSA-5621480	0.997344	0.001	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	0.997540	0.001	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	0.997552	0.001	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	0.997552	0.001	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	0.997729	0.001	0	0
TCR signaling	R-HSA-202403	0.997730	0.001	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	0.997877	0.001	0	0
Transmission across Chemical Synapses	R-HSA-112315	0.997981	0.001	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	0.998048	0.001	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	0.998095	0.001	0	0
GABA receptor activation	R-HSA-977443	0.998102	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	0.998102	0.001	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	0.998146	0.001	0	0
Selenocysteine synthesis	R-HSA-2408557	0.998251	0.001	0	0
Neddylation	R-HSA-8951664	0.998300	0.001	0	0
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	0.998320	0.001	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	0.998518	0.001	0	0
Gap junction trafficking	R-HSA-190828	0.998518	0.001	0	0
Methylation	R-HSA-156581	0.998518	0.001	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	0.998518	0.001	0	0
PCP/CE pathway	R-HSA-4086400	0.998545	0.001	0	0
ABC transporter disorders	R-HSA-5619084	0.998545	0.001	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	0.998545	0.001	0	0
Viral mRNA Translation	R-HSA-192823	0.998548	0.001	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	0.998661	0.001	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	0.998692	0.001	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	0.998692	0.001	0	0
Disorders of transmembrane transporters	R-HSA-5619115	0.998728	0.001	0	0
Ion transport by P-type ATPases	R-HSA-936837	0.998791	0.001	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	0.998847	0.001	0	0
Amyloid fiber formation	R-HSA-977225	0.998938	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	0.998938	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	0.998983	0.000	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	0.998983	0.000	0	0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	0.998983	0.000	0	0
Platelet homeostasis	R-HSA-418346	0.999003	0.000	0	0
Leishmania phagocytosis	R-HSA-9664417	0.999047	0.000	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	0.999047	0.000	0	0
Parasite infection	R-HSA-9664407	0.999047	0.000	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	0.999053	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	0.999096	0.000	0	0
Gluconeogenesis	R-HSA-70263	0.999103	0.000	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	0.999112	0.000	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	0.999124	0.000	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	0.999140	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	0.999232	0.000	0	0
Ion channel transport	R-HSA-983712	0.999269	0.000	0	0
Complex IV assembly	R-HSA-9864848	0.999384	0.000	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	0.999384	0.000	0	0
Cytosolic sulfonation of small molecules	R-HSA-156584	0.999384	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	0.999513	0.000	0	0
Nucleotide biosynthesis	R-HSA-8956320	0.999521	0.000	0	0
Developmental Cell Lineages	R-HSA-9734767	0.999567	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	0.999584	0.000	1	0
ROS and RNS production in phagocytes	R-HSA-1222556	0.999613	0.000	0	0
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	0.999627	0.000	0	0
Downstream TCR signaling	R-HSA-202424	0.999633	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	0.999655	0.000	0	0
Ion homeostasis	R-HSA-5578775	0.999671	0.000	0	0
Protein localization	R-HSA-9609507	0.999713	0.000	0	0
Metabolism of steroids	R-HSA-8957322	0.999719	0.000	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	0.999753	0.000	0	0
Interleukin-10 signaling	R-HSA-6783783	0.999755	0.000	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	0.999761	0.000	0	0
Metabolism of polyamines	R-HSA-351202	0.999801	0.000	0	0
Signaling by Retinoic Acid	R-HSA-5362517	0.999801	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	0.999845	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	0.999878	0.000	0	0
Glycosphingolipid biosynthesis	R-HSA-9840309	0.999880	0.000	0	0
Xenobiotics	R-HSA-211981	0.999880	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	0.999888	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	0.999893	0.000	0	0
ABC-family proteins mediated transport	R-HSA-382556	0.999900	0.000	0	0
Vesicle-mediated transport	R-HSA-5653656	0.999913	0.000	0	0
Pyruvate metabolism	R-HSA-70268	0.999923	0.000	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	0.999945	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	0.999946	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	0.999947	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	0.999950	0.000	0	0
Purine catabolism	R-HSA-74259	0.999956	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	0.999961	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	0.999962	0.000	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	0.999966	0.000	0	0
Selenoamino acid metabolism	R-HSA-2408522	0.999969	0.000	0	0
Iron uptake and transport	R-HSA-917937	0.999970	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	0.999970	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	0.999973	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	0.999982	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	0.999986	0.000	0	0
Muscle contraction	R-HSA-397014	0.999987	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	0.999990	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	0.999993	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	0.999993	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	0.999993	0.000	0	0
Keratinization	R-HSA-6805567	0.999993	0.000	0	0
O-linked glycosylation	R-HSA-5173105	0.999994	0.000	0	0
Antigen processing-Cross presentation	R-HSA-1236975	0.999995	0.000	0	0
ER-Phagosome pathway	R-HSA-1236974	0.999995	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	0.999996	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	0.999997	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	0.999997	0.000	0	0
Parasitic Infection Pathways	R-HSA-9824443	0.999997	0.000	0	0
Leishmania infection	R-HSA-9658195	0.999997	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	0.999997	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	0.999998	0.000	0	0
Cardiac conduction	R-HSA-5576891	0.999998	0.000	0	0
Respiratory electron transport	R-HSA-611105	0.999998	0.000	0	0
Adaptive Immune System	R-HSA-1280218	0.999998	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	0.999999	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	0.999999	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	0.999999	0.000	0	0
Hemostasis	R-HSA-109582	0.999999	0.000	0	0
Translation	R-HSA-72766	0.999999	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	0.999999	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	1.000000	0.000	0	0
Visual phototransduction	R-HSA-2187338	1.000000	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	1.000000	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000	0.000	0	0
Mitochondrial translation	R-HSA-5368287	1.000000	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	1.000000	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000	0.000	0	0
Neutrophil degranulation	R-HSA-6798695	1.000000	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	1.000000	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000	0.000	1	0
Infection with Enterobacteria	R-HSA-9640148	1.000000	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000	0.000	0	0
GPCR downstream signalling	R-HSA-388396	1.000000	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000	0.000	0	0
Immune System	R-HSA-168256	1.000000	0.000	0	0
Disease	R-HSA-1643685	1.000000	0.000	1	0
Post-translational protein modification	R-HSA-597592	1.000000	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	1.000000	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	1.000000	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000	0.000	0	0
Innate Immune System	R-HSA-168249	1.000000	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000	-0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000	-0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000	-0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000	-0.000	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	1.000000	0.000	1	1

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Chromatin organization	R-HSA-4839726	4.715809e-07	6.326	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.825519e-07	6.008	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	1.044773e-06	5.981	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	1.044773e-06	5.981	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.481586e-06	5.829	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.955987e-06	5.305	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	8.823495e-06	5.054	0	0
Cell Cycle, Mitotic	R-HSA-69278	7.601358e-06	5.119	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	9.363795e-06	5.029	0	0
Signal Transduction	R-HSA-162582	9.942144e-06	5.003	1	0
Chromatin modifying enzymes	R-HSA-3247509	4.200050e-05	4.377	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.419141e-05	4.266	0	0
Cell Cycle	R-HSA-1640170	7.895985e-05	4.103	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.054142e-04	3.977	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.222801e-04	3.913	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.332600e-04	3.875	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.742174e-04	3.759	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.947139e-04	3.711	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.112633e-04	3.675	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.322717e-04	3.634	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	3.079172e-04	3.512	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	3.165758e-04	3.500	0	0
mRNA Splicing	R-HSA-72172	4.047998e-04	3.393	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.336966e-04	3.363	0	0
M Phase	R-HSA-68886	4.278341e-04	3.369	0	0
Mitotic Anaphase	R-HSA-68882	3.792623e-04	3.421	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	4.035219e-04	3.394	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	4.624175e-04	3.335	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	5.348039e-04	3.272	0	0
Amplification of signal from the kinetochores	R-HSA-141424	5.348039e-04	3.272	0	0
MITF-M-dependent gene expression	R-HSA-9856651	6.865856e-04	3.163	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	7.461971e-04	3.127	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	8.205777e-04	3.086	0	0
Signaling by Hippo	R-HSA-2028269	1.164129e-03	2.934	0	0
TGFBR3 expression	R-HSA-9839394	1.369401e-03	2.863	0	0
MTOR signalling	R-HSA-165159	1.450702e-03	2.838	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	1.522520e-03	2.817	0	0
Gene expression (Transcription)	R-HSA-74160	1.561447e-03	2.806	1	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.656113e-03	2.781	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.090043e-03	2.680	0	0
Mitotic Prometaphase	R-HSA-68877	2.140308e-03	2.670	0	0
NRAGE signals death through JNK	R-HSA-193648	2.267518e-03	2.644	0	0
Apoptotic execution phase	R-HSA-75153	2.421805e-03	2.616	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.743243e-03	2.562	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.816435e-03	2.550	0	0
Activation of the pre-replicative complex	R-HSA-68962	3.131101e-03	2.504	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.131101e-03	2.504	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.056839e-03	2.515	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.211590e-03	2.493	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	3.630448e-03	2.440	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	3.630448e-03	2.440	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	3.648797e-03	2.438	0	0
Cell-extracellular matrix interactions	R-HSA-446353	3.446787e-03	2.463	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	3.467932e-03	2.460	0	0
Cell Cycle Checkpoints	R-HSA-69620	3.600266e-03	2.444	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	3.554769e-03	2.449	1	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.830417e-03	2.417	0	0
Separation of Sister Chromatids	R-HSA-2467813	3.888231e-03	2.410	0	0
PKMTs methylate histone lysines	R-HSA-3214841	4.130678e-03	2.384	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.037693e-03	2.394	0	0
DNA strand elongation	R-HSA-69190	4.188125e-03	2.378	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.232976e-03	2.373	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	4.808293e-03	2.318	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	4.808293e-03	2.318	0	0
mRNA 3'-end processing	R-HSA-72187	4.774893e-03	2.321	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.515685e-03	2.345	0	0
Deadenylation of mRNA	R-HSA-429947	5.301699e-03	2.276	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.495168e-03	2.260	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	5.473721e-03	2.262	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	5.159241e-03	2.287	1	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	5.629263e-03	2.250	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	5.486748e-03	2.261	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	5.066642e-03	2.295	0	0
HIV Life Cycle	R-HSA-162587	5.632201e-03	2.249	1	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	5.495168e-03	2.260	0	0
Nuclear import of Rev protein	R-HSA-180746	6.253003e-03	2.204	0	0
Regulation of TP53 Activity	R-HSA-5633007	6.645275e-03	2.177	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	7.086073e-03	2.150	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	7.347465e-03	2.134	0	0
Activation of RAC1	R-HSA-428540	8.284478e-03	2.082	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	8.779383e-03	2.057	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.995041e-03	2.046	0	0
Cell junction organization	R-HSA-446728	8.460849e-03	2.073	0	0
Cellular Senescence	R-HSA-2559583	9.546462e-03	2.020	0	0
RNA Polymerase II Transcription	R-HSA-73857	9.882977e-03	2.005	1	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.007638e-02	1.997	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.007946e-02	1.997	0	0
Death Receptor Signaling	R-HSA-73887	1.007638e-02	1.997	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.224833e-02	1.912	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.224833e-02	1.912	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	1.162159e-02	1.935	0	0
Adipogenesis	R-HSA-9843745	1.158297e-02	1.936	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	1.123749e-02	1.949	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.123749e-02	1.949	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	1.125611e-02	1.949	0	0
Mitotic Prophase	R-HSA-68875	1.197829e-02	1.922	0	0
Heme signaling	R-HSA-9707616	1.223442e-02	1.912	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.125611e-02	1.949	0	0
Interleukin-37 signaling	R-HSA-9008059	1.224833e-02	1.912	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	1.234445e-02	1.909	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.235009e-02	1.908	1	1
Transcriptional regulation by RUNX3	R-HSA-8878159	1.241570e-02	1.906	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.261209e-02	1.899	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.261209e-02	1.899	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	1.252916e-02	1.902	0	0
Cellular response to heat stress	R-HSA-3371556	1.269477e-02	1.896	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.371297e-02	1.863	0	0
ISG15 antiviral mechanism	R-HSA-1169408	1.294399e-02	1.888	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	1.252916e-02	1.902	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.252916e-02	1.902	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.390267e-02	1.857	0	0
UCH proteinases	R-HSA-5689603	1.395084e-02	1.855	0	0
HATs acetylate histones	R-HSA-3214847	1.412805e-02	1.850	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.412805e-02	1.850	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.430160e-02	1.845	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.430160e-02	1.845	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	1.589490e-02	1.799	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.589490e-02	1.799	0	0
SOS-mediated signalling	R-HSA-112412	1.589490e-02	1.799	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	1.538064e-02	1.813	0	0
HIV Transcription Initiation	R-HSA-167161	1.538064e-02	1.813	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	1.538064e-02	1.813	0	0
mTORC1-mediated signalling	R-HSA-166208	1.645677e-02	1.784	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.555975e-02	1.808	0	0
S Phase	R-HSA-69242	1.517514e-02	1.819	0	0
G alpha (12/13) signalling events	R-HSA-416482	1.613884e-02	1.792	0	0
Nuclear RNA decay	R-HSA-9930044	1.742782e-02	1.759	0	0
Processive synthesis on the lagging strand	R-HSA-69183	1.816508e-02	1.741	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	1.816508e-02	1.741	0	0
DCC mediated attractive signaling	R-HSA-418885	1.816508e-02	1.741	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	1.866537e-02	1.729	0	0
TBC/RABGAPs	R-HSA-8854214	1.866537e-02	1.729	0	0
Regulation of TP53 Expression	R-HSA-6804754	1.882234e-02	1.725	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.882234e-02	1.725	0	0
Cell-Cell communication	R-HSA-1500931	1.932979e-02	1.714	0	0
Type I hemidesmosome assembly	R-HSA-446107	2.037218e-02	1.691	0	0
Formation of annular gap junctions	R-HSA-196025	2.037218e-02	1.691	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	2.241300e-02	1.649	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.241300e-02	1.649	0	0
Oncogene Induced Senescence	R-HSA-2559585	2.394174e-02	1.621	0	0
HIV Infection	R-HSA-162906	2.139742e-02	1.670	1	0
Developmental Biology	R-HSA-1266738	2.333562e-02	1.632	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	2.142950e-02	1.669	0	0
Synthesis of DNA	R-HSA-69239	2.413478e-02	1.617	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	2.446907e-02	1.611	0	0
Signaling by TGFBR3	R-HSA-9839373	2.446907e-02	1.611	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.446907e-02	1.611	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.503078e-02	1.602	0	0
Gap junction degradation	R-HSA-190873	2.547135e-02	1.594	0	0
Unwinding of DNA	R-HSA-176974	2.547135e-02	1.594	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	2.579369e-02	1.588	0	0
Regulation of beta-cell development	R-HSA-186712	2.579369e-02	1.588	0	0
Oncogenic MAPK signaling	R-HSA-6802957	2.581790e-02	1.588	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	2.612550e-02	1.583	0	0
Myogenesis	R-HSA-525793	2.719847e-02	1.565	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.779983e-02	1.556	0	0
MET interacts with TNS proteins	R-HSA-8875513	2.842981e-02	1.546	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.842981e-02	1.546	0	0
Specification of primordial germ cells	R-HSA-9827857	2.897540e-02	1.538	0	0
G1/S Transition	R-HSA-69206	3.438801e-02	1.464	0	0
Signal attenuation	R-HSA-74749	3.119139e-02	1.506	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.987275e-02	1.525	1	1
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.326811e-02	1.478	0	0
Nephron development	R-HSA-9831926	3.326811e-02	1.478	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.326811e-02	1.478	0	0
Metabolism of RNA	R-HSA-8953854	3.584088e-02	1.446	0	0
PTEN Regulation	R-HSA-6807070	3.675492e-02	1.435	0	0
Regulation of endogenous retroelements	R-HSA-9842860	3.706509e-02	1.431	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	3.706509e-02	1.431	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.846104e-02	1.415	1	1
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.945529e-02	1.404	0	0
Regulation of gap junction activity	R-HSA-191650	3.958066e-02	1.403	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	3.958066e-02	1.403	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	3.958066e-02	1.403	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	3.958066e-02	1.403	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	3.958066e-02	1.403	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.143541e-02	1.383	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.143541e-02	1.383	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.159259e-02	1.381	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.212521e-02	1.375	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	5.065168e-02	1.295	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	5.065168e-02	1.295	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.446469e-02	1.352	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.446469e-02	1.352	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.199273e-02	1.284	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	5.199273e-02	1.284	0	0
Repression of WNT target genes	R-HSA-4641265	5.199273e-02	1.284	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.199273e-02	1.284	0	0
Lagging Strand Synthesis	R-HSA-69186	4.825777e-02	1.316	0	0
Transcription of the HIV genome	R-HSA-167172	4.781737e-02	1.320	1	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.825777e-02	1.316	0	0
Circadian clock	R-HSA-9909396	4.931728e-02	1.307	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.199273e-02	1.284	0	0
Signaling by NOTCH3	R-HSA-9012852	4.895727e-02	1.310	0	0
PIP3 activates AKT signaling	R-HSA-1257604	4.376187e-02	1.359	0	0
Signaling by LTK	R-HSA-9842663	5.199273e-02	1.284	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.700997e-02	1.328	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.700997e-02	1.328	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.332809e-02	1.363	0	0
Generic Transcription Pathway	R-HSA-212436	4.567337e-02	1.340	1	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.199273e-02	1.284	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.010025e-02	1.300	0	0
Signaling by ALK in cancer	R-HSA-9700206	5.010025e-02	1.300	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.922146e-02	1.308	0	0
IRS activation	R-HSA-74713	5.209429e-02	1.283	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.209429e-02	1.283	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	5.209429e-02	1.283	0	0
G2 Phase	R-HSA-68911	5.209429e-02	1.283	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.209429e-02	1.283	0	0
Signaling by EGFR	R-HSA-177929	5.238391e-02	1.281	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.395809e-02	1.268	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.426242e-02	1.266	0	0
Activation of ATR in response to replication stress	R-HSA-176187	5.491303e-02	1.260	0	0
DNA Replication Pre-Initiation	R-HSA-69002	5.505695e-02	1.259	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.820453e-02	1.235	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	5.984076e-02	1.223	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	6.009242e-02	1.221	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	6.092935e-02	1.215	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.132855e-02	1.212	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.354617e-02	1.197	0	0
snRNP Assembly	R-HSA-191859	6.354921e-02	1.197	0	0
Metabolism of non-coding RNA	R-HSA-194441	6.354921e-02	1.197	0	0
Switching of origins to a post-replicative state	R-HSA-69052	6.416037e-02	1.193	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	8.055791e-02	1.094	0	0
Removal of the Flap Intermediate	R-HSA-69166	6.874326e-02	1.163	0	0
RAF activation	R-HSA-5673000	6.501183e-02	1.187	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	6.538250e-02	1.185	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.538250e-02	1.185	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.538250e-02	1.185	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	7.313071e-02	1.136	0	0
Signaling by RAS mutants	R-HSA-6802949	6.538250e-02	1.185	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.478162e-02	1.126	0	0
Signaling by WNT	R-HSA-195721	7.426351e-02	1.129	0	0
Regulation of KIT signaling	R-HSA-1433559	6.874326e-02	1.163	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	6.756841e-02	1.170	0	0
Membrane Trafficking	R-HSA-199991	6.914112e-02	1.160	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	7.313071e-02	1.136	0	0
Adherens junctions interactions	R-HSA-418990	7.676160e-02	1.115	0	0
RUNX2 regulates bone development	R-HSA-8941326	7.607858e-02	1.119	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	6.580437e-02	1.182	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	8.055791e-02	1.094	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	7.447116e-02	1.128	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	7.809588e-02	1.107	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	6.981046e-02	1.156	0	0
tRNA processing in the nucleus	R-HSA-6784531	7.605470e-02	1.119	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.197001e-02	1.086	0	0
Rab regulation of trafficking	R-HSA-9007101	8.467673e-02	1.072	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.758275e-02	1.058	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.758275e-02	1.058	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.760556e-02	1.057	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	8.760556e-02	1.057	0	0
Nucleotide Excision Repair	R-HSA-5696398	8.887995e-02	1.051	0	0
Apoptosis	R-HSA-109581	9.201889e-02	1.036	0	0
Signaling by ALK	R-HSA-201556	9.445414e-02	1.025	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	9.528746e-02	1.021	0	0
Orc1 removal from chromatin	R-HSA-68949	9.597034e-02	1.018	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	9.621430e-02	1.017	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	9.621430e-02	1.017	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	9.621430e-02	1.017	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	9.621430e-02	1.017	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	9.621430e-02	1.017	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	9.621430e-02	1.017	0	0
Intracellular signaling by second messengers	R-HSA-9006925	9.632442e-02	1.016	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.674918e-02	1.014	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	9.776643e-02	1.010	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	9.776643e-02	1.010	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	9.776643e-02	1.010	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	9.874067e-02	1.006	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	9.874067e-02	1.006	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.004348e-01	0.998	0	0
Aggrephagy	R-HSA-9646399	1.010393e-01	0.996	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.017013e-01	0.993	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.126445e-01	0.948	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.126445e-01	0.948	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.297301e-01	0.887	0	0
WNT mediated activation of DVL	R-HSA-201688	1.297301e-01	0.887	0	0
ALK mutants bind TKIs	R-HSA-9700645	1.297301e-01	0.887	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.194123e-01	0.923	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	1.194123e-01	0.923	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.308408e-01	0.883	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.308408e-01	0.883	0	0
Signaling by RAF1 mutants	R-HSA-9656223	1.148734e-01	0.940	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.199362e-01	0.921	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.158997e-01	0.936	0	0
Cyclin D associated events in G1	R-HSA-69231	1.372037e-01	0.863	0	0
G1 Phase	R-HSA-69236	1.372037e-01	0.863	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.148734e-01	0.940	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	1.308408e-01	0.883	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.083780e-01	0.965	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.116080e-01	0.952	0	0
DNA Replication	R-HSA-69306	1.150806e-01	0.939	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	1.297301e-01	0.887	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	1.194123e-01	0.923	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	1.078474e-01	0.967	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.075018e-01	0.969	1	1
Regulation of CDH11 gene transcription	R-HSA-9762293	1.297301e-01	0.887	0	0
Selective autophagy	R-HSA-9663891	1.371508e-01	0.863	0	0
Macroautophagy	R-HSA-1632852	1.268004e-01	0.897	0	0
Protein-protein interactions at synapses	R-HSA-6794362	1.160018e-01	0.936	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	1.083780e-01	0.965	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	1.083780e-01	0.965	0	0
Deubiquitination	R-HSA-5688426	1.324138e-01	0.878	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.297301e-01	0.887	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.297301e-01	0.887	0	0
Mismatch Repair	R-HSA-5358508	1.194123e-01	0.923	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.272885e-01	0.895	0	0
Signaling by VEGF	R-HSA-194138	1.183915e-01	0.927	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.126445e-01	0.948	0	0
Inositol phosphate metabolism	R-HSA-1483249	1.171380e-01	0.931	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.263520e-01	0.898	0	0
RMTs methylate histone arginines	R-HSA-3214858	1.372037e-01	0.863	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	1.263448e-01	0.898	0	0
Regulation of gene expression in beta cells	R-HSA-210745	1.116080e-01	0.952	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.426348e-01	0.846	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	1.426348e-01	0.846	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	1.426348e-01	0.846	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.443965e-01	0.840	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	1.443965e-01	0.840	0	0
Defective MMADHC causes MMAHCD	R-HSA-3359473	1.443965e-01	0.840	0	0
Transport of connexins along the secretory pathway	R-HSA-190827	1.443965e-01	0.840	0	0
Oligomerization of connexins into connexons	R-HSA-190704	1.443965e-01	0.840	0	0
Breakdown of the nuclear lamina	R-HSA-352238	1.443965e-01	0.840	0	0
PI3K/AKT activation	R-HSA-198203	1.473629e-01	0.832	0	0
Josephin domain DUBs	R-HSA-5689877	1.473629e-01	0.832	0	0
Signaling by Leptin	R-HSA-2586552	1.473629e-01	0.832	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.475905e-01	0.831	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.475905e-01	0.831	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.484062e-01	0.829	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.496997e-01	0.825	0	0
Signaling by NOTCH1	R-HSA-1980143	1.516687e-01	0.819	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	1.530721e-01	0.815	0	0
Formation of paraxial mesoderm	R-HSA-9793380	1.536080e-01	0.814	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.877421e-01	0.726	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	1.877421e-01	0.726	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	1.877421e-01	0.726	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	1.877421e-01	0.726	0	0
Defective MMACHC causes MAHCC	R-HSA-3359474	2.288943e-01	0.640	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.288943e-01	0.640	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.288943e-01	0.640	0	0
HCN channels	R-HSA-1296061	2.679639e-01	0.572	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	2.679639e-01	0.572	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.679639e-01	0.572	0	0
Signaling by APC mutants	R-HSA-4839744	1.654437e-01	0.781	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.654437e-01	0.781	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.654437e-01	0.781	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.654437e-01	0.781	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	3.050562e-01	0.516	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.838820e-01	0.735	0	0
Polymerase switching	R-HSA-69091	2.025954e-01	0.693	0	0
Leading Strand Synthesis	R-HSA-69109	2.025954e-01	0.693	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.025954e-01	0.693	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.025954e-01	0.693	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.025954e-01	0.693	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.025954e-01	0.693	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.025954e-01	0.693	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.402712e-01	0.468	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.402712e-01	0.468	0	0
Phosphorylation of Emi1	R-HSA-176417	3.402712e-01	0.468	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	3.402712e-01	0.468	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.547655e-01	0.810	0	0
Signaling by LTK in cancer	R-HSA-9842640	3.737038e-01	0.427	0	0
Erythropoietin activates STAT5	R-HSA-9027283	3.737038e-01	0.427	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.737038e-01	0.427	0	0
Notch-HLH transcription pathway	R-HSA-350054	1.799218e-01	0.745	0	0
Erythropoietin activates RAS	R-HSA-9027284	2.596694e-01	0.586	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	2.596694e-01	0.586	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	1.928908e-01	0.715	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	1.928908e-01	0.715	0	0
Phosphorylation of the APC/C	R-HSA-176412	2.787989e-01	0.555	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.787989e-01	0.555	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	4.054440e-01	0.392	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	4.054440e-01	0.392	0	0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	4.054440e-01	0.392	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.054440e-01	0.392	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.670605e-01	0.777	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	2.978921e-01	0.526	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.978921e-01	0.526	0	0
G1/S-Specific Transcription	R-HSA-69205	1.873790e-01	0.727	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.612806e-01	0.792	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	2.467357e-01	0.608	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.467357e-01	0.608	1	1
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.467357e-01	0.608	1	1
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.169038e-01	0.499	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.355775e-01	0.361	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	4.355775e-01	0.361	0	0
MET receptor recycling	R-HSA-8875656	4.355775e-01	0.361	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.605597e-01	0.584	0	0
HIV elongation arrest and recovery	R-HSA-167287	2.605597e-01	0.584	1	1
Formation of the Early Elongation Complex	R-HSA-113418	2.605597e-01	0.584	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.605597e-01	0.584	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	2.605597e-01	0.584	1	1
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.301313e-01	0.638	0	0
HSF1-dependent transactivation	R-HSA-3371571	1.957710e-01	0.708	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.681342e-01	0.774	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.681342e-01	0.774	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.047691e-01	0.689	0	0
ARMS-mediated activation	R-HSA-170984	4.641855e-01	0.333	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.139015e-01	0.670	0	0
AURKA Activation by TPX2	R-HSA-8854518	1.909430e-01	0.719	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.636219e-01	0.579	0	0
Co-inhibition by CTLA4	R-HSA-389513	3.730635e-01	0.428	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.325361e-01	0.634	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.420220e-01	0.616	0	0
Striated Muscle Contraction	R-HSA-390522	3.447534e-01	0.462	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.481994e-01	0.605	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.095047e-01	0.509	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	3.588025e-01	0.445	0	0
Dual Incision in GG-NER	R-HSA-5696400	3.588025e-01	0.445	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	2.653987e-01	0.576	0	0
Centrosome maturation	R-HSA-380287	2.653987e-01	0.576	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.435342e-01	0.613	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	3.728077e-01	0.429	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	4.272660e-01	0.369	0	0
FGFR2 alternative splicing	R-HSA-6803529	4.272660e-01	0.369	0	0
Regulation of RAS by GAPs	R-HSA-5658442	3.560712e-01	0.448	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	3.793849e-01	0.421	1	1
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.910131e-01	0.408	1	1
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.910131e-01	0.408	0	0
Attenuation phase	R-HSA-3371568	4.416421e-01	0.355	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.416421e-01	0.355	1	1
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.484999e-01	0.348	0	0
Dual incision in TC-NER	R-HSA-6782135	4.484999e-01	0.348	0	0
PPARA activates gene expression	R-HSA-1989781	4.115540e-01	0.386	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	3.048755e-01	0.516	0	0
HIV Transcription Elongation	R-HSA-167169	4.416421e-01	0.355	1	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.313361e-01	0.636	0	0
Regulation of mitotic cell cycle	R-HSA-453276	2.313361e-01	0.636	0	0
HCMV Early Events	R-HSA-9609690	2.340129e-01	0.631	0	0
mRNA Capping	R-HSA-72086	2.744798e-01	0.561	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.978336e-01	0.704	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.978336e-01	0.704	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	2.744798e-01	0.561	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.978336e-01	0.704	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.397229e-01	0.620	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.416421e-01	0.355	1	1
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	3.457337e-01	0.461	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	2.979402e-01	0.526	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.007780e-01	0.522	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.550776e-01	0.342	0	0
DNA Damage Bypass	R-HSA-73893	1.782097e-01	0.749	0	0
G0 and Early G1	R-HSA-1538133	3.165924e-01	0.499	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.884731e-01	0.540	0	0
PCP/CE pathway	R-HSA-4086400	2.917280e-01	0.535	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.672040e-01	0.777	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	4.272660e-01	0.369	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.301313e-01	0.638	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.411812e-01	0.618	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	3.165924e-01	0.499	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.280799e-01	0.368	1	1
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	3.588025e-01	0.445	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	3.050562e-01	0.516	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.355775e-01	0.361	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	4.641855e-01	0.333	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.867527e-01	0.413	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.550729e-01	0.809	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.550729e-01	0.809	0	0
FOXO-mediated transcription	R-HSA-9614085	3.482795e-01	0.458	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	2.330317e-01	0.633	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.782097e-01	0.749	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	2.523492e-01	0.598	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.598080e-01	0.337	0	0
Degradation of DVL	R-HSA-4641258	1.978229e-01	0.704	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.313361e-01	0.636	0	0
Extension of Telomeres	R-HSA-180786	2.710549e-01	0.567	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.910131e-01	0.408	0	0
Gap junction trafficking and regulation	R-HSA-157858	3.444059e-01	0.463	0	0
MET activates RAS signaling	R-HSA-8851805	2.025954e-01	0.693	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.050562e-01	0.516	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	3.050562e-01	0.516	0	0
Killing mechanisms	R-HSA-9664420	2.787989e-01	0.555	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	2.787989e-01	0.555	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.978921e-01	0.526	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.884731e-01	0.540	0	0
Chromosome Maintenance	R-HSA-73886	4.038313e-01	0.394	0	0
Signaling by WNT in cancer	R-HSA-4791275	3.165924e-01	0.499	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	3.566768e-01	0.448	0	0
HCMV Infection	R-HSA-9609646	4.331983e-01	0.363	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.654437e-01	0.781	0	0
Regulation of Apoptosis	R-HSA-169911	3.728077e-01	0.429	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.838820e-01	0.735	0	0
Regulation of CDH1 Function	R-HSA-9764561	4.371183e-01	0.359	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.641855e-01	0.333	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	3.977874e-01	0.400	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	1.877421e-01	0.726	0	0
C6 deamination of adenosine	R-HSA-75102	1.877421e-01	0.726	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	2.288943e-01	0.640	0	0
Reelin signalling pathway	R-HSA-8866376	3.050562e-01	0.516	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.838820e-01	0.735	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.838820e-01	0.735	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.838820e-01	0.735	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.838820e-01	0.735	0	0
Synthesis of PS	R-HSA-1483101	3.402712e-01	0.468	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.215088e-01	0.655	0	0
G2/M DNA replication checkpoint	R-HSA-69478	3.737038e-01	0.427	0	0
Adrenoceptors	R-HSA-390696	4.355775e-01	0.361	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.355775e-01	0.361	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	3.357931e-01	0.474	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.545238e-01	0.450	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.447534e-01	0.462	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.793849e-01	0.421	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.620052e-01	0.335	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	4.026095e-01	0.395	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.416421e-01	0.355	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.416421e-01	0.355	0	0
Signaling by NOTCH	R-HSA-157118	3.778066e-01	0.423	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	4.008063e-01	0.397	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.668924e-01	0.574	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.330317e-01	0.633	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	3.357931e-01	0.474	0	0
DNA Repair	R-HSA-73894	4.185831e-01	0.378	0	0
RAF/MAP kinase cascade	R-HSA-5673001	3.455195e-01	0.462	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.094583e-01	0.388	0	0
G2/M Checkpoints	R-HSA-69481	2.093218e-01	0.679	0	0
EGFR downregulation	R-HSA-182971	3.025176e-01	0.519	0	0
Signaling by NOTCH4	R-HSA-9013694	2.567599e-01	0.590	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.004900e-01	0.698	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.355775e-01	0.361	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	3.802477e-01	0.420	0	0
Cell-cell junction organization	R-HSA-421270	1.771859e-01	0.752	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.021211e-01	0.396	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.605597e-01	0.584	0	0
Negative regulation of MET activity	R-HSA-6807004	3.730635e-01	0.428	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.061934e-01	0.686	0	0
Co-inhibition by PD-1	R-HSA-389948	3.533901e-01	0.452	0	0
Signaling by NOTCH2	R-HSA-1980145	3.588025e-01	0.445	0	0
Autophagy	R-HSA-9612973	2.002525e-01	0.698	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.679639e-01	0.572	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.799218e-01	0.745	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.054440e-01	0.392	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.641855e-01	0.333	0	0
Degradation of CDH1	R-HSA-9766229	3.444059e-01	0.463	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	3.793849e-01	0.421	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.722009e-01	0.764	0	0
MAPK family signaling cascades	R-HSA-5683057	2.097061e-01	0.678	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	2.734233e-01	0.563	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.025954e-01	0.693	0	0
p75NTR regulates axonogenesis	R-HSA-193697	4.641855e-01	0.333	0	0
Neurexins and neuroligins	R-HSA-6794361	2.047691e-01	0.689	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.978921e-01	0.526	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.025176e-01	0.519	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	3.306773e-01	0.481	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.115540e-01	0.386	0	0
HDMs demethylate histones	R-HSA-3214842	2.194724e-01	0.659	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	2.523492e-01	0.598	0	0
Cellular responses to stress	R-HSA-2262752	2.595739e-01	0.586	0	0
Signaling by KIT in disease	R-HSA-9669938	4.272660e-01	0.369	0	0
Protein ubiquitination	R-HSA-8852135	4.324549e-01	0.364	0	0
Sensory perception of sour taste	R-HSA-9729555	2.679639e-01	0.572	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.402712e-01	0.468	0	0
Retrograde neurotrophin signalling	R-HSA-177504	2.405541e-01	0.619	0	0
VLDL clearance	R-HSA-8964046	4.054440e-01	0.392	0	0
Disorders of Developmental Biology	R-HSA-9675151	2.978921e-01	0.526	0	0
mRNA Editing	R-HSA-75072	4.641855e-01	0.333	0	0
Regulation of signaling by NODAL	R-HSA-1433617	4.641855e-01	0.333	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.913834e-01	0.407	0	0
Interleukin receptor SHC signaling	R-HSA-912526	4.447872e-01	0.352	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.620052e-01	0.335	0	0
Neurodegenerative Diseases	R-HSA-8863678	4.620052e-01	0.335	0	0
Cellular responses to stimuli	R-HSA-8953897	3.934603e-01	0.405	0	0
Signaling by MET	R-HSA-6806834	1.780392e-01	0.749	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.867527e-01	0.413	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	2.134836e-01	0.671	0	0
Carnitine shuttle	R-HSA-200425	4.447872e-01	0.352	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	3.190964e-01	0.496	0	0
Suppression of apoptosis	R-HSA-9635465	1.654437e-01	0.781	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.067701e-01	0.685	0	0
ERK/MAPK targets	R-HSA-198753	3.913834e-01	0.407	0	0
Ovarian tumor domain proteases	R-HSA-5689896	4.006224e-01	0.397	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.805105e-01	0.420	0	0
RNA Polymerase III Transcription	R-HSA-74158	3.867527e-01	0.413	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.978921e-01	0.526	0	0
Mitotic G2-G2/M phases	R-HSA-453274	1.956509e-01	0.709	0	0
Co-stimulation by CD28	R-HSA-389356	3.327490e-01	0.478	0	0
Base Excision Repair	R-HSA-73884	4.096849e-01	0.388	0	0
Signaling by PDGFR in disease	R-HSA-9671555	1.672040e-01	0.777	0	0
NADPH regeneration	R-HSA-389542	3.737038e-01	0.427	0	0
Regulation of PTEN localization	R-HSA-8948747	4.054440e-01	0.392	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	4.054440e-01	0.392	0	0
Sodium/Proton exchangers	R-HSA-425986	4.355775e-01	0.361	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	2.192126e-01	0.659	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.744798e-01	0.561	0	0
Signaling by NODAL	R-HSA-1181150	3.730635e-01	0.428	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.006224e-01	0.397	1	1
G2/M Transition	R-HSA-69275	3.794141e-01	0.421	0	0
NGF-stimulated transcription	R-HSA-9031628	1.696622e-01	0.770	0	0
Sensory processing of sound	R-HSA-9659379	3.006230e-01	0.522	0	0
GP1b-IX-V activation signalling	R-HSA-430116	4.641855e-01	0.333	0	0
Mitochondrial biogenesis	R-HSA-1592230	2.457639e-01	0.609	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	3.882795e-01	0.411	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.272660e-01	0.369	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	1.799218e-01	0.745	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	4.094583e-01	0.388	0	0
Signaling by TGFB family members	R-HSA-9006936	3.237771e-01	0.490	1	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.402712e-01	0.468	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.215088e-01	0.655	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.596694e-01	0.586	0	0
Polo-like kinase mediated events	R-HSA-156711	3.357931e-01	0.474	0	0
Lipophagy	R-HSA-9613354	4.641855e-01	0.333	0	0
Gene Silencing by RNA	R-HSA-211000	1.717441e-01	0.765	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	3.817908e-01	0.418	0	0
Signaling by NTRKs	R-HSA-166520	1.613997e-01	0.792	0	0
FLT3 Signaling	R-HSA-9607240	4.550776e-01	0.342	0	0
Host Interactions of HIV factors	R-HSA-162909	1.866286e-01	0.729	1	0
Signaling by ROBO receptors	R-HSA-376176	2.698574e-01	0.569	0	0
TNF signaling	R-HSA-75893	2.420220e-01	0.616	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.306773e-01	0.481	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.021211e-01	0.396	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.256707e-01	0.371	1	0
Uptake and function of anthrax toxins	R-HSA-5210891	3.169038e-01	0.499	0	0
RSV-host interactions	R-HSA-9833110	3.984416e-01	0.400	0	0
Netrin-1 signaling	R-HSA-373752	2.864301e-01	0.543	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.050562e-01	0.516	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.596694e-01	0.586	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.280799e-01	0.368	0	0
Glycolysis	R-HSA-70171	2.243854e-01	0.649	0	0
RET signaling	R-HSA-8853659	1.873790e-01	0.727	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.327490e-01	0.478	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	4.256707e-01	0.371	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.787989e-01	0.555	0	0
Programmed Cell Death	R-HSA-5357801	1.997158e-01	0.700	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.228958e-01	0.491	0	0
STING mediated induction of host immune responses	R-HSA-1834941	3.545238e-01	0.450	0	0
Kidney development	R-HSA-9830369	3.512644e-01	0.454	0	0
Interleukin-7 signaling	R-HSA-1266695	2.194724e-01	0.659	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	2.710549e-01	0.567	0	0
IRE1alpha activates chaperones	R-HSA-381070	1.600953e-01	0.796	0	0
Glucose metabolism	R-HSA-70326	3.727502e-01	0.429	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.272660e-01	0.369	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	4.226740e-01	0.374	0	0
Interleukin-1 family signaling	R-HSA-446652	3.909106e-01	0.408	0	0
Growth hormone receptor signaling	R-HSA-982772	4.447872e-01	0.352	0	0
Vesicle-mediated transport	R-HSA-5653656	4.651380e-01	0.332	0	0
ESR-mediated signaling	R-HSA-8939211	4.665993e-01	0.331	1	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.683758e-01	0.329	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	4.683758e-01	0.329	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.710353e-01	0.327	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.710353e-01	0.327	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.710353e-01	0.327	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.710353e-01	0.327	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.710353e-01	0.327	0	0
Signaling by ERBB2	R-HSA-1227986	4.710353e-01	0.327	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	4.723492e-01	0.326	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	4.733461e-01	0.325	0	0
Nervous system development	R-HSA-9675108	4.773622e-01	0.321	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.789058e-01	0.320	0	0
Acyl chain remodelling of PS	R-HSA-1482801	4.789058e-01	0.320	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.815267e-01	0.317	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.815267e-01	0.317	0	0
COPI-mediated anterograde transport	R-HSA-6807878	4.819338e-01	0.317	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	4.821750e-01	0.317	0	0
MAP kinase activation	R-HSA-450294	4.821750e-01	0.317	0	0
Axon guidance	R-HSA-422475	4.823351e-01	0.317	0	0
Telomere Maintenance	R-HSA-157579	4.907974e-01	0.309	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.913451e-01	0.309	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.913451e-01	0.309	0	0
DNA replication initiation	R-HSA-68952	4.913451e-01	0.309	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.913451e-01	0.309	0	0
Regulation of CDH11 function	R-HSA-9762292	4.913451e-01	0.309	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.913451e-01	0.309	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	4.913451e-01	0.309	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	4.913451e-01	0.309	0	0
Pexophagy	R-HSA-9664873	4.913451e-01	0.309	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	4.913451e-01	0.309	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	4.913451e-01	0.309	0	0
Signaling by SCF-KIT	R-HSA-1433557	4.945215e-01	0.306	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.954768e-01	0.305	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.954768e-01	0.305	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.978484e-01	0.303	0	0
Gastrulation	R-HSA-9758941	5.020248e-01	0.299	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.041666e-01	0.297	0	0
Gap junction trafficking	R-HSA-190828	5.073517e-01	0.295	0	0
EPHB-mediated forward signaling	R-HSA-3928662	5.073517e-01	0.295	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.117084e-01	0.291	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.117084e-01	0.291	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	5.117084e-01	0.291	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.117084e-01	0.291	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.117084e-01	0.291	0	0
IGF1R signaling cascade	R-HSA-2428924	5.150066e-01	0.288	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	5.171296e-01	0.286	0	0
LGI-ADAM interactions	R-HSA-5682910	5.171296e-01	0.286	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.171296e-01	0.286	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	5.171296e-01	0.286	0	0
PECAM1 interactions	R-HSA-210990	5.171296e-01	0.286	0	0
Somitogenesis	R-HSA-9824272	5.200100e-01	0.284	0	0
Cilium Assembly	R-HSA-5617833	5.243859e-01	0.280	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.257356e-01	0.279	0	0
Cellular response to hypoxia	R-HSA-1234174	5.257356e-01	0.279	0	0
Homology Directed Repair	R-HSA-5693538	5.299295e-01	0.276	0	0
Interferon Signaling	R-HSA-913531	5.300476e-01	0.276	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.397319e-01	0.268	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.416085e-01	0.266	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.416085e-01	0.266	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	5.416085e-01	0.266	0	0
NF-kB is activated and signals survival	R-HSA-209560	5.416085e-01	0.266	0	0
ERKs are inactivated	R-HSA-202670	5.416085e-01	0.266	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.416085e-01	0.266	0	0
Signaling by Erythropoietin	R-HSA-9006335	5.431221e-01	0.265	0	0
Late endosomal microautophagy	R-HSA-9615710	5.431221e-01	0.265	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.431221e-01	0.265	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.431221e-01	0.265	0	0
Recycling pathway of L1	R-HSA-437239	5.447842e-01	0.264	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.468104e-01	0.262	0	0
DNA Double Strand Break Response	R-HSA-5693606	5.468412e-01	0.262	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.468412e-01	0.262	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.534579e-01	0.257	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.568885e-01	0.254	0	0
HCMV Late Events	R-HSA-9610379	5.577249e-01	0.254	0	0
Activation of BH3-only proteins	R-HSA-114452	5.582929e-01	0.253	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.582929e-01	0.253	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.582929e-01	0.253	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.648479e-01	0.248	0	0
GRB2 events in EGFR signaling	R-HSA-179812	5.648479e-01	0.248	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.648479e-01	0.248	0	0
p75NTR recruits signalling complexes	R-HSA-209543	5.648479e-01	0.248	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	5.648479e-01	0.248	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.648479e-01	0.248	0	0
VLDLR internalisation and degradation	R-HSA-8866427	5.648479e-01	0.248	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.648479e-01	0.248	0	0
Disorders of Nervous System Development	R-HSA-9697154	5.648479e-01	0.248	0	0
Pervasive developmental disorders	R-HSA-9005895	5.648479e-01	0.248	0	0
OAS antiviral response	R-HSA-8983711	5.648479e-01	0.248	0	0
Interleukin-15 signaling	R-HSA-8983432	5.648479e-01	0.248	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.674478e-01	0.246	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	5.699906e-01	0.244	0	0
Parasite infection	R-HSA-9664407	5.699906e-01	0.244	0	0
Leishmania phagocytosis	R-HSA-9664417	5.699906e-01	0.244	0	0
Budding and maturation of HIV virion	R-HSA-162588	5.731011e-01	0.242	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	5.731011e-01	0.242	0	0
Cargo concentration in the ER	R-HSA-5694530	5.731011e-01	0.242	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	5.731011e-01	0.242	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	5.770994e-01	0.239	0	0
Interleukin-17 signaling	R-HSA-448424	5.775542e-01	0.238	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.775542e-01	0.238	0	0
Influenza Infection	R-HSA-168255	5.789518e-01	0.237	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	5.805074e-01	0.236	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.869105e-01	0.231	0	0
Formation of axial mesoderm	R-HSA-9796292	5.869105e-01	0.231	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.869105e-01	0.231	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.869105e-01	0.231	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	5.869105e-01	0.231	0	0
Maturation of nucleoprotein	R-HSA-9683610	5.869105e-01	0.231	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.869105e-01	0.231	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	5.875250e-01	0.231	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	5.875446e-01	0.231	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.973571e-01	0.224	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.016222e-01	0.221	0	0
Integrin signaling	R-HSA-354192	6.016222e-01	0.221	0	0
G-protein beta:gamma signalling	R-HSA-397795	6.016222e-01	0.221	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.016222e-01	0.221	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.078557e-01	0.216	0	0
CRMPs in Sema3A signaling	R-HSA-399956	6.078557e-01	0.216	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.078557e-01	0.216	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	6.078557e-01	0.216	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	6.078557e-01	0.216	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	6.078557e-01	0.216	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	6.078557e-01	0.216	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.078557e-01	0.216	0	0
Developmental Cell Lineages	R-HSA-9734767	6.100165e-01	0.215	0	0
Smooth Muscle Contraction	R-HSA-445355	6.144062e-01	0.212	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.153340e-01	0.211	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.153340e-01	0.211	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	6.153340e-01	0.211	0	0
Vpu mediated degradation of CD4	R-HSA-180534	6.153340e-01	0.211	0	0
Miscellaneous transport and binding events	R-HSA-5223345	6.153340e-01	0.211	0	0
G2/M DNA damage checkpoint	R-HSA-69473	6.165946e-01	0.210	0	0
Signaling by FGFR in disease	R-HSA-1226099	6.165946e-01	0.210	0	0
SLC transporter disorders	R-HSA-5619102	6.234488e-01	0.205	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.259955e-01	0.203	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.259955e-01	0.203	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.277401e-01	0.202	0	0
Translesion synthesis by REV1	R-HSA-110312	6.277401e-01	0.202	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	6.277401e-01	0.202	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.277401e-01	0.202	0	0
SHC1 events in EGFR signaling	R-HSA-180336	6.277401e-01	0.202	0	0
p75NTR signals via NF-kB	R-HSA-193639	6.277401e-01	0.202	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.277401e-01	0.202	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.277401e-01	0.202	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	6.277401e-01	0.202	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.277401e-01	0.202	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.277401e-01	0.202	0	0
Collagen formation	R-HSA-1474290	6.283287e-01	0.202	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.286807e-01	0.202	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.286807e-01	0.202	0	0
Mitophagy	R-HSA-5205647	6.286807e-01	0.202	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	6.286807e-01	0.202	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	6.286807e-01	0.202	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.286807e-01	0.202	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.286807e-01	0.202	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.318877e-01	0.199	0	0
Reproduction	R-HSA-1474165	6.348453e-01	0.197	0	0
HDACs deacetylate histones	R-HSA-3214815	6.359552e-01	0.197	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	6.371476e-01	0.196	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	6.389476e-01	0.195	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	6.416643e-01	0.193	0	0
Signalling to ERKs	R-HSA-187687	6.416643e-01	0.193	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.416643e-01	0.193	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.443521e-01	0.191	0	0
Translesion synthesis by POLI	R-HSA-5656121	6.466174e-01	0.189	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.466174e-01	0.189	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	6.466174e-01	0.189	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.466174e-01	0.189	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.466174e-01	0.189	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	6.466174e-01	0.189	0	0
Prolonged ERK activation events	R-HSA-169893	6.466174e-01	0.189	0	0
Differentiation of T cells	R-HSA-9945266	6.466174e-01	0.189	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.466174e-01	0.189	0	0
Negative regulation of FLT3	R-HSA-9706369	6.466174e-01	0.189	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.466174e-01	0.189	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.537514e-01	0.185	0	0
HSF1 activation	R-HSA-3371511	6.542871e-01	0.184	0	0
PRC2 methylates histones and DNA	R-HSA-212300	6.542871e-01	0.184	0	0
FLT3 signaling in disease	R-HSA-9682385	6.542871e-01	0.184	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	6.542871e-01	0.184	0	0
Glycosphingolipid transport	R-HSA-9845576	6.542871e-01	0.184	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	6.542871e-01	0.184	0	0
IRS-mediated signalling	R-HSA-112399	6.566493e-01	0.183	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.573517e-01	0.182	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	6.607283e-01	0.180	1	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.645385e-01	0.177	0	0
Translesion synthesis by POLK	R-HSA-5655862	6.645385e-01	0.177	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	6.645385e-01	0.177	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	6.645385e-01	0.177	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	6.665523e-01	0.176	0	0
Degradation of AXIN	R-HSA-4641257	6.665523e-01	0.176	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	6.665523e-01	0.176	0	0
Collagen chain trimerization	R-HSA-8948216	6.665523e-01	0.176	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.666739e-01	0.176	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.685364e-01	0.175	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.685364e-01	0.175	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.685364e-01	0.175	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.779257e-01	0.169	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.784639e-01	0.168	0	0
MET promotes cell motility	R-HSA-8875878	6.784639e-01	0.168	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.784639e-01	0.168	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	6.792477e-01	0.168	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.815518e-01	0.167	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	6.815518e-01	0.167	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	6.815518e-01	0.167	0	0
Glycogen storage diseases	R-HSA-3229121	6.815518e-01	0.167	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.815518e-01	0.167	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.815518e-01	0.167	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.815518e-01	0.167	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.815518e-01	0.167	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.815518e-01	0.167	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.815518e-01	0.167	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.875878e-01	0.163	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.883622e-01	0.162	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.890889e-01	0.162	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.890889e-01	0.162	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	6.900260e-01	0.161	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.900260e-01	0.161	0	0
Plasma lipoprotein clearance	R-HSA-8964043	6.900260e-01	0.161	0	0
Stabilization of p53	R-HSA-69541	6.900260e-01	0.161	0	0
Cytoprotection by HMOX1	R-HSA-9707564	6.957736e-01	0.158	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	6.977032e-01	0.156	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.977032e-01	0.156	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	6.977032e-01	0.156	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.977032e-01	0.156	0	0
Ephrin signaling	R-HSA-3928664	6.977032e-01	0.156	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	6.977032e-01	0.156	0	0
Tie2 Signaling	R-HSA-210993	6.977032e-01	0.156	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	6.977032e-01	0.156	0	0
Platelet sensitization by LDL	R-HSA-432142	6.977032e-01	0.156	0	0
GAB1 signalosome	R-HSA-180292	6.977032e-01	0.156	0	0
Signaling by Interleukins	R-HSA-449147	6.994420e-01	0.155	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.012435e-01	0.154	0	0
Glycogen metabolism	R-HSA-8982491	7.012435e-01	0.154	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.012435e-01	0.154	0	0
Generation of second messenger molecules	R-HSA-202433	7.012435e-01	0.154	0	0
Interleukin-2 family signaling	R-HSA-451927	7.012435e-01	0.154	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.046244e-01	0.152	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	7.091150e-01	0.149	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	7.091150e-01	0.149	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	7.116317e-01	0.148	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	7.121215e-01	0.147	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	7.121215e-01	0.147	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	7.121215e-01	0.147	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	7.121215e-01	0.147	0	0
Translesion Synthesis by POLH	R-HSA-110320	7.130364e-01	0.147	0	0
Regulation of signaling by CBL	R-HSA-912631	7.130364e-01	0.147	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.130364e-01	0.147	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.130364e-01	0.147	0	0
Rap1 signalling	R-HSA-392517	7.130364e-01	0.147	0	0
Specification of the neural plate border	R-HSA-9834899	7.130364e-01	0.147	0	0
Maturation of nucleoprotein	R-HSA-9694631	7.130364e-01	0.147	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.130364e-01	0.147	0	0
Semaphorin interactions	R-HSA-373755	7.135786e-01	0.147	0	0
Signaling by PTK6	R-HSA-8848021	7.135786e-01	0.147	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.135786e-01	0.147	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.194043e-01	0.143	0	0
Insulin receptor signalling cascade	R-HSA-74751	7.223217e-01	0.141	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	7.226657e-01	0.141	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	7.226657e-01	0.141	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.226657e-01	0.141	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.226657e-01	0.141	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.226657e-01	0.141	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	7.236392e-01	0.140	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.275927e-01	0.138	0	0
Glycogen synthesis	R-HSA-3322077	7.275927e-01	0.138	0	0
Formation of definitive endoderm	R-HSA-9823730	7.275927e-01	0.138	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	7.275927e-01	0.138	0	0
Protein hydroxylation	R-HSA-9629569	7.275927e-01	0.138	0	0
Signal transduction by L1	R-HSA-445144	7.275927e-01	0.138	0	0
Nephrin family interactions	R-HSA-373753	7.275927e-01	0.138	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	7.328819e-01	0.135	0	0
Depyrimidination	R-HSA-73928	7.328819e-01	0.135	0	0
Post NMDA receptor activation events	R-HSA-438064	7.343886e-01	0.134	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.414115e-01	0.130	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.414115e-01	0.130	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	7.414115e-01	0.130	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.414115e-01	0.130	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.414115e-01	0.130	0	0
Signalling to RAS	R-HSA-167044	7.414115e-01	0.130	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.414115e-01	0.130	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.414115e-01	0.130	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	7.414115e-01	0.130	0	0
Diseases of programmed cell death	R-HSA-9645723	7.416516e-01	0.130	0	0
Defective pyroptosis	R-HSA-9710421	7.427762e-01	0.129	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.427762e-01	0.129	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.427762e-01	0.129	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	7.427762e-01	0.129	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.464896e-01	0.127	0	0
Stimuli-sensing channels	R-HSA-2672351	7.464896e-01	0.127	0	0
ER-Phagosome pathway	R-HSA-1236974	7.487629e-01	0.126	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	7.523550e-01	0.124	0	0
Proteasome assembly	R-HSA-9907900	7.523550e-01	0.124	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	7.523550e-01	0.124	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.528515e-01	0.123	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.545301e-01	0.122	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.545301e-01	0.122	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.545301e-01	0.122	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	7.545301e-01	0.122	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.545301e-01	0.122	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.545301e-01	0.122	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	7.545301e-01	0.122	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	7.616248e-01	0.118	0	0
Nucleosome assembly	R-HSA-774815	7.616248e-01	0.118	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.616248e-01	0.118	0	0
Fanconi Anemia Pathway	R-HSA-6783310	7.616248e-01	0.118	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.616248e-01	0.118	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	7.616248e-01	0.118	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.616248e-01	0.118	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	7.616248e-01	0.118	0	0
Toll-like Receptor Cascades	R-HSA-168898	7.621504e-01	0.118	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.669839e-01	0.115	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.669839e-01	0.115	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	7.669839e-01	0.115	0	0
LDL clearance	R-HSA-8964038	7.669839e-01	0.115	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.704528e-01	0.113	0	0
COPII-mediated vesicle transport	R-HSA-204005	7.704528e-01	0.113	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.705923e-01	0.113	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	7.705923e-01	0.113	0	0
Diseases of DNA repair	R-HSA-9675135	7.705923e-01	0.113	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.742905e-01	0.111	0	0
EPH-Ephrin signaling	R-HSA-2682334	7.757111e-01	0.110	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.771077e-01	0.110	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	7.777745e-01	0.109	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.777745e-01	0.109	0	0
Hedgehog 'on' state	R-HSA-5632684	7.777745e-01	0.109	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	7.788066e-01	0.109	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	7.788066e-01	0.109	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.788066e-01	0.109	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.788066e-01	0.109	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.788066e-01	0.109	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	7.788066e-01	0.109	0	0
Syndecan interactions	R-HSA-3000170	7.788066e-01	0.109	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.792643e-01	0.108	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.792643e-01	0.108	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	7.802417e-01	0.108	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	7.849030e-01	0.105	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.900301e-01	0.102	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	7.900301e-01	0.102	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.900301e-01	0.102	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	7.900301e-01	0.102	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.900301e-01	0.102	0	0
Ca2+ pathway	R-HSA-4086398	7.918414e-01	0.101	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.943865e-01	0.100	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.957495e-01	0.099	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.957495e-01	0.099	0	0
Long-term potentiation	R-HSA-9620244	8.006848e-01	0.097	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.006848e-01	0.097	0	0
Defects in cobalamin (B12) metabolism	R-HSA-3296469	8.006848e-01	0.097	0	0
Hyaluronan degradation	R-HSA-2160916	8.006848e-01	0.097	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.006848e-01	0.097	0	0
Laminin interactions	R-HSA-3000157	8.006848e-01	0.097	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.006848e-01	0.097	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.006848e-01	0.097	0	0
Formation of the nephric duct	R-HSA-9830364	8.006848e-01	0.097	0	0
PI3K Cascade	R-HSA-109704	8.035765e-01	0.095	0	0
L1CAM interactions	R-HSA-373760	8.048048e-01	0.094	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	8.061280e-01	0.094	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.107994e-01	0.091	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	8.107994e-01	0.091	0	0
Metalloprotease DUBs	R-HSA-5689901	8.107994e-01	0.091	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.107994e-01	0.091	0	0
TRP channels	R-HSA-3295583	8.107994e-01	0.091	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.107994e-01	0.091	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	8.111359e-01	0.091	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.111359e-01	0.091	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	8.111359e-01	0.091	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.115451e-01	0.091	0	0
Disorders of transmembrane transporters	R-HSA-5619115	8.183189e-01	0.087	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.184345e-01	0.087	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	8.184345e-01	0.087	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	8.204013e-01	0.086	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	8.204013e-01	0.086	0	0
Cobalamin (Cbl) metabolism	R-HSA-9759218	8.204013e-01	0.086	0	0
Signaling by BMP	R-HSA-201451	8.204013e-01	0.086	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.204013e-01	0.086	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	8.204013e-01	0.086	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.204013e-01	0.086	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.204013e-01	0.086	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.204013e-01	0.086	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	8.237863e-01	0.084	0	0
RNA Polymerase I Transcription	R-HSA-73864	8.237863e-01	0.084	0	0
Cholesterol biosynthesis	R-HSA-191273	8.237863e-01	0.084	0	0
Meiotic synapsis	R-HSA-1221632	8.254795e-01	0.083	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	8.254795e-01	0.083	0	0
Telomere Extension By Telomerase	R-HSA-171319	8.295165e-01	0.081	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.295165e-01	0.081	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.295165e-01	0.081	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.295165e-01	0.081	0	0
Translation initiation complex formation	R-HSA-72649	8.322777e-01	0.080	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.322777e-01	0.080	0	0
Interleukin-1 signaling	R-HSA-9020702	8.331035e-01	0.079	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.353420e-01	0.078	0	0
Signaling by FGFR2	R-HSA-5654738	8.353420e-01	0.078	0	0
PKR-mediated signaling	R-HSA-9833482	8.353420e-01	0.078	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.381061e-01	0.077	0	0
Platelet calcium homeostasis	R-HSA-418360	8.381696e-01	0.077	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	8.381696e-01	0.077	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	8.381696e-01	0.077	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.381696e-01	0.077	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.388360e-01	0.076	0	0
MHC class II antigen presentation	R-HSA-2132295	8.389135e-01	0.076	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	8.451613e-01	0.073	0	0
Ion homeostasis	R-HSA-5578775	8.451613e-01	0.073	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	8.451613e-01	0.073	0	0
DAP12 signaling	R-HSA-2424491	8.463839e-01	0.072	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	8.463839e-01	0.072	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.463839e-01	0.072	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	8.463839e-01	0.072	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.477348e-01	0.072	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.541818e-01	0.068	0	0
Downstream signal transduction	R-HSA-186763	8.541818e-01	0.068	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	8.568754e-01	0.067	0	0
tRNA processing	R-HSA-72306	8.598750e-01	0.066	0	0
Meiosis	R-HSA-1500620	8.614089e-01	0.065	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	8.615843e-01	0.065	0	0
SARS-CoV-2 Infection	R-HSA-9694516	8.621972e-01	0.064	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	8.633506e-01	0.064	0	0
Metabolism of polyamines	R-HSA-351202	8.682655e-01	0.061	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.686115e-01	0.061	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	8.686115e-01	0.061	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.686115e-01	0.061	0	0
Cardiogenesis	R-HSA-9733709	8.686115e-01	0.061	0	0
Regulation of necroptotic cell death	R-HSA-5675482	8.686115e-01	0.061	0	0
Antigen processing-Cross presentation	R-HSA-1236975	8.697081e-01	0.061	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.735248e-01	0.059	0	0
Collagen degradation	R-HSA-1442490	8.735248e-01	0.059	0	0
Chaperonin-mediated protein folding	R-HSA-390466	8.752491e-01	0.058	0	0
Resolution of D-Loop Structures	R-HSA-5693537	8.752823e-01	0.058	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.777028e-01	0.057	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	8.777028e-01	0.057	0	0
TCR signaling	R-HSA-202403	8.777028e-01	0.057	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.785902e-01	0.056	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	8.785902e-01	0.056	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.785902e-01	0.056	0	0
Signaling by PDGF	R-HSA-186797	8.785902e-01	0.056	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	8.815480e-01	0.055	0	0
eNOS activation	R-HSA-203615	8.816148e-01	0.055	0	0
Gap junction assembly	R-HSA-190861	8.816148e-01	0.055	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.816148e-01	0.055	0	0
Hyaluronan metabolism	R-HSA-2142845	8.816148e-01	0.055	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.816148e-01	0.055	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	8.816148e-01	0.055	0	0
Cellular response to chemical stress	R-HSA-9711123	8.822454e-01	0.054	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	8.834678e-01	0.054	0	0
FCERI mediated MAPK activation	R-HSA-2871796	8.852691e-01	0.053	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	8.876261e-01	0.052	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	8.876261e-01	0.052	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	8.876261e-01	0.052	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.876261e-01	0.052	0	0
PERK regulates gene expression	R-HSA-381042	8.876261e-01	0.052	0	0
Transferrin endocytosis and recycling	R-HSA-917977	8.876261e-01	0.052	0	0
Neurotransmitter release cycle	R-HSA-112310	8.878503e-01	0.052	0	0
Ion transport by P-type ATPases	R-HSA-936837	8.881634e-01	0.052	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	8.917908e-01	0.050	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	8.924244e-01	0.049	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	8.926831e-01	0.049	0	0
Viral Infection Pathways	R-HSA-9824446	8.931151e-01	0.049	1	0
Lysosome Vesicle Biogenesis	R-HSA-432720	8.933325e-01	0.049	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.933325e-01	0.049	0	0
Regulation of TP53 Degradation	R-HSA-6804757	8.933325e-01	0.049	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	8.943192e-01	0.049	1	0
Interferon gamma signaling	R-HSA-877300	8.972148e-01	0.047	0	0
Voltage gated Potassium channels	R-HSA-1296072	8.987495e-01	0.046	0	0
SLC-mediated transport of organic cations	R-HSA-549127	8.987495e-01	0.046	0	0
Signaling by Insulin receptor	R-HSA-74752	8.993014e-01	0.046	0	0
Protein folding	R-HSA-391251	8.993014e-01	0.046	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.028778e-01	0.044	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.038917e-01	0.044	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.038917e-01	0.044	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.052432e-01	0.043	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.052432e-01	0.043	0	0
Eukaryotic Translation Initiation	R-HSA-72613	9.055695e-01	0.043	0	0
Cap-dependent Translation Initiation	R-HSA-72737	9.055695e-01	0.043	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.087730e-01	0.042	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.128387e-01	0.040	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.129288e-01	0.040	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.134067e-01	0.039	0	0
Diseases of Immune System	R-HSA-5260271	9.134067e-01	0.039	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.134067e-01	0.039	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	9.134067e-01	0.039	0	0
Muscle contraction	R-HSA-397014	9.145926e-01	0.039	0	0
Ion channel transport	R-HSA-983712	9.146887e-01	0.039	0	0
Metabolism of cofactors	R-HSA-8978934	9.164188e-01	0.038	0	0
Maturation of spike protein	R-HSA-9694548	9.178053e-01	0.037	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.178053e-01	0.037	0	0
SARS-CoV Infections	R-HSA-9679506	9.216262e-01	0.035	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.219807e-01	0.035	0	0
Translation of Structural Proteins	R-HSA-9683701	9.219807e-01	0.035	0	0
Signaling by FGFR	R-HSA-190236	9.220254e-01	0.035	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.259443e-01	0.033	0	0
Signaling by ERBB4	R-HSA-1236394	9.263471e-01	0.033	0	0
Hedgehog 'off' state	R-HSA-5610787	9.275980e-01	0.033	0	0
Formation of the cornified envelope	R-HSA-6809371	9.276608e-01	0.033	0	0
Signaling by FGFR4	R-HSA-5654743	9.297067e-01	0.032	0	0
Interleukin-12 signaling	R-HSA-9020591	9.323362e-01	0.030	0	0
PI Metabolism	R-HSA-1483255	9.328029e-01	0.030	0	0
DAP12 interactions	R-HSA-2172127	9.332782e-01	0.030	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.332782e-01	0.030	0	0
Amine ligand-binding receptors	R-HSA-375280	9.332782e-01	0.030	0	0
Ub-specific processing proteases	R-HSA-5689880	9.332797e-01	0.030	0	0
Translation of Structural Proteins	R-HSA-9694635	9.351550e-01	0.029	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.362694e-01	0.029	0	0
Signaling by FGFR3	R-HSA-5654741	9.366685e-01	0.028	0	0
DAG and IP3 signaling	R-HSA-1489509	9.366685e-01	0.028	0	0
Platelet degranulation	R-HSA-114608	9.368591e-01	0.028	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	9.376612e-01	0.028	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.378623e-01	0.028	0	0
ABC transporter disorders	R-HSA-5619084	9.378623e-01	0.028	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.401967e-01	0.027	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.401967e-01	0.027	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.404622e-01	0.027	0	0
Synthesis of PC	R-HSA-1483191	9.429414e-01	0.026	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.429585e-01	0.026	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.430467e-01	0.025	0	0
Platelet homeostasis	R-HSA-418346	9.443428e-01	0.025	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	9.443428e-01	0.025	0	0
Amyloid fiber formation	R-HSA-977225	9.453551e-01	0.024	0	0
Metal ion SLC transporters	R-HSA-425410	9.458412e-01	0.024	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.464180e-01	0.024	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.484212e-01	0.023	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.484212e-01	0.023	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.485938e-01	0.023	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.498637e-01	0.022	0	0
Leishmania infection	R-HSA-9658195	9.500741e-01	0.022	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.500741e-01	0.022	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.504364e-01	0.022	0	0
Cellular response to starvation	R-HSA-9711097	9.507056e-01	0.022	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.507056e-01	0.022	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.513335e-01	0.022	0	0
Meiotic recombination	R-HSA-912446	9.536868e-01	0.021	0	0
Complex IV assembly	R-HSA-9864848	9.536868e-01	0.021	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.557563e-01	0.020	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.557563e-01	0.020	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	9.560410e-01	0.020	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.560410e-01	0.020	0	0
Amino acids regulate mTORC1	R-HSA-9639288	9.582757e-01	0.019	0	0
Interleukin-12 family signaling	R-HSA-447115	9.596335e-01	0.018	0	0
G alpha (z) signalling events	R-HSA-418597	9.624105e-01	0.017	0	0
Signaling by FGFR1	R-HSA-5654736	9.643217e-01	0.016	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.643217e-01	0.016	0	0
Downstream TCR signaling	R-HSA-202424	9.645899e-01	0.016	0	0
Dectin-2 family	R-HSA-5621480	9.661359e-01	0.015	0	0
Neddylation	R-HSA-8951664	9.669043e-01	0.015	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.675634e-01	0.014	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.678580e-01	0.014	0	0
Eukaryotic Translation Elongation	R-HSA-156842	9.689586e-01	0.014	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.689586e-01	0.014	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.689586e-01	0.014	0	0
Peroxisomal protein import	R-HSA-9033241	9.694925e-01	0.013	0	0
Kinesins	R-HSA-983189	9.710441e-01	0.013	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.710441e-01	0.013	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.715775e-01	0.013	0	0
SARS-CoV-1 Infection	R-HSA-9678108	9.729490e-01	0.012	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.733981e-01	0.012	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.736767e-01	0.012	0	0
Potassium Channels	R-HSA-1296071	9.751103e-01	0.011	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.751103e-01	0.011	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.767463e-01	0.010	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.772256e-01	0.010	0	0
Protein localization	R-HSA-9609507	9.775369e-01	0.010	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.791665e-01	0.009	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	9.800758e-01	0.009	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.809306e-01	0.008	0	0
Regulated Necrosis	R-HSA-5218859	9.809306e-01	0.008	0	0
Neuronal System	R-HSA-112316	9.828114e-01	0.008	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.828220e-01	0.008	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.836962e-01	0.007	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.853136e-01	0.006	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	9.853136e-01	0.006	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	9.853760e-01	0.006	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.860612e-01	0.006	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.867707e-01	0.006	0	0
Iron uptake and transport	R-HSA-917937	9.867707e-01	0.006	0	0
Ribosome-associated quality control	R-HSA-9948299	9.871392e-01	0.006	0	0
Signaling by Hedgehog	R-HSA-5358351	9.871392e-01	0.006	0	0
Antimicrobial peptides	R-HSA-6803157	9.878523e-01	0.005	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.885860e-01	0.005	0	0
Integrin cell surface interactions	R-HSA-216083	9.886901e-01	0.005	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.898692e-01	0.004	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.907512e-01	0.004	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.929344e-01	0.003	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.929706e-01	0.003	0	0
Peptide chain elongation	R-HSA-156902	9.936360e-01	0.003	0	0
Extracellular matrix organization	R-HSA-1474244	9.942933e-01	0.002	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.943282e-01	0.002	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.945601e-01	0.002	0	0
FCGR activation	R-HSA-2029481	9.953501e-01	0.002	0	0
Adaptive Immune System	R-HSA-1280218	9.956098e-01	0.002	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.958121e-01	0.002	0	0
Cardiac conduction	R-HSA-5576891	9.959589e-01	0.002	0	0
Eukaryotic Translation Termination	R-HSA-72764	9.960256e-01	0.002	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	9.960256e-01	0.002	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.961421e-01	0.002	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.962282e-01	0.002	0	0
Post-translational protein modification	R-HSA-597592	9.962895e-01	0.002	0	0
Regulation of insulin secretion	R-HSA-422356	9.966030e-01	0.001	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.967762e-01	0.001	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.968797e-01	0.001	0	0
Integration of energy metabolism	R-HSA-163685	9.969427e-01	0.001	0	0
Phospholipid metabolism	R-HSA-1483257	9.970725e-01	0.001	0	0
Selenocysteine synthesis	R-HSA-2408557	9.970966e-01	0.001	0	0
Metabolism of steroids	R-HSA-8957322	9.971035e-01	0.001	0	0
Keratinization	R-HSA-6805567	9.973448e-01	0.001	0	0
Viral mRNA Translation	R-HSA-192823	9.973852e-01	0.001	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.979190e-01	0.001	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.979930e-01	0.001	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.982533e-01	0.001	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.982800e-01	0.001	0	0
Infectious disease	R-HSA-5663205	9.985598e-01	0.001	1	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.988080e-01	0.001	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.988080e-01	0.001	0	0
Disease	R-HSA-1643685	9.988888e-01	0.000	1	0
Transmission across Chemical Synapses	R-HSA-112315	9.989246e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.989266e-01	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	9.990466e-01	0.000	0	0
rRNA processing	R-HSA-72312	9.990876e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.992596e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.993645e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.994002e-01	0.000	0	0
G alpha (s) signalling events	R-HSA-418555	9.994671e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.995361e-01	0.000	0	0
Hemostasis	R-HSA-109582	9.995581e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.996787e-01	0.000	0	0
Immune System	R-HSA-168256	9.997337e-01	0.000	0	0
Neutrophil degranulation	R-HSA-6798695	9.997907e-01	0.000	0	0
Translation	R-HSA-72766	9.998035e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.998418e-01	0.000	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.999262e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999379e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999564e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999564e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999648e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999665e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999709e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999755e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999787e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999848e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999900e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999972e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999978e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999995e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999995e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	9.999998e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999999e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	1.000000e+00	0.000	1	1