HIPK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00115 S70 Sugiyama DNASE2 DNASE2A DNL2 QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O14639 S431 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 TSGYDDKQERQsLGEsPRtLsPtPsAEGyQDVRDRMIHRst
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60829 T51 SIGNOR|EPSD|PSP PAGE4 GAGEC1 JM27 QQEEPPTDNQDIEPGQEREGtPPIEERKVEGDCQEMDLEKt
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P10586 S1853 Sugiyama PTPRF LAR GPITVHCSAGVGRtGVFItLsIVLERMRyEGVVDMFQTVKT
P10586 T1846 Sugiyama PTPRF LAR KEQFGQDGPITVHCSAGVGRtGVFItLsIVLERMRyEGVVD
P10586 T1851 Sugiyama PTPRF LAR QDGPITVHCSAGVGRtGVFItLsIVLERMRyEGVVDMFQTV
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142 T37 Sugiyama HSPA8 HSC70 HSP73 HSPA10 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142 T38 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P17812 S573 Sugiyama CTPS1 CTPS HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23468 S1858 Sugiyama PTPRD GPISVHCSAGVGRtGVFItLsIVLERMRYEGVVDIFQTVKM
P23468 T1851 Sugiyama PTPRD KEQFGQDGPISVHCSAGVGRtGVFItLsIVLERMRYEGVVD
P23468 T1856 Sugiyama PTPRD QDGPISVHCSAGVGRtGVFItLsIVLERMRYEGVVDIFQTV
P25054 S1389 Sugiyama APC DP2.5 PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27824 S362 Sugiyama CANX WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401 T287 Sugiyama TKT AEQIIQEIysQIQsKKKILAtPPQEDAPsVDIANIRMPsLP
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086 T51 Sugiyama PEBP1 PBP PEBP GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931 T39 Sugiyama HSPA1L CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931 T40 Sugiyama HSPA1L VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35269 S385 Sugiyama GTF2F1 RAP74 KKKTPPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAA
P35269 T389 Sugiyama GTF2F1 RAP74 PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P42166 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167 T160 Sugiyama TMPO LAP2 KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P51608 S216 EPSD|PSP MECP2 TTRPKAATSEGVQVKRVLEKsPGKLLVKMPFQtsPGGKAEG
P51608 S80 EPSD|PSP MECP2 GKAETsEGsGsAPAVPEAsAsPKQRRSIIRDRGPMYDDPTL
P54652 T38 Sugiyama HSPA2 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652 T39 Sugiyama HSPA2 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07666 S35 Sugiyama KHDRBS1 SAM68 sGRsGsMDPsGAHPsVRQtPsRQPPLPHRSRGGGGGSRGGA
Q13283 S231 Sugiyama G3BP1 G3BP QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13332 S1894 Sugiyama PTPRS GPISVHCSAGVGRtGVFItLsIVLERMRYEGVVDIFQTVKM
Q13332 T1887 Sugiyama PTPRS KEQFGQDGPISVHCSAGVGRtGVFItLsIVLERMRYEGVVD
Q13332 T1892 Sugiyama PTPRS QDGPISVHCSAGVGRtGVFItLsIVLERMRYEGVVDIFQTV
Q13428 T1014 Sugiyama TCOF1 ARssssEsEDEDVIPAtQCLtPGIRTNVVTMPTAHPRIAPK
Q13573 S182 Sugiyama SNW1 SKIIP SKIP AMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRVIRMVEM
Q13586 S620 Sugiyama STIM1 GOK sPsAPPGGsPHLDssRsHsPssPDPDtPsPVGDSRALQASR
Q14160 S1448 Sugiyama SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL QEDEQPPWAsPsPtsRQsPAsPPPLGGGAPVRTAKAERRHQ
Q14247 S405 Sugiyama CTTN EMS1 EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14258 S100 Sugiyama TRIM25 EFP RNF147 ZNF147 DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q71RC2 S597 Sugiyama LARP4 PP13296 QttIPVsPPsttKPsRAstAsPCNNNINAAtAVALQEPRKL
Q7Z2W4 T273 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q86YP4 S100 Sugiyama GATAD2A DGPVDMRTSHSDMKSERRPPsPDVIVLsDNEQPssPRVNGL
Q86Z02 S239 Sugiyama HIPK1 KIAA0630 MYAK NBAK2 KILKNHPSYARQGQIEVSILsRLSsENADEYNFVRSYECFQ
Q86Z02 S243 Sugiyama HIPK1 KIAA0630 MYAK NBAK2 NHPSYARQGQIEVSILsRLSsENADEYNFVRSYECFQHKNH
Q86Z02 S355 Sugiyama HIPK1 KIAA0630 MYAK NBAK2 VIDFGSAsHVSKAVCstyLQsRYYRAPEIILGLPFCEAIDM
Q86Z02 Y352 Sugiyama HIPK1 KIAA0630 MYAK NBAK2 RVKVIDFGSAsHVSKAVCstyLQsRYYRAPEIILGLPFCEA
Q8IWW6 S240 Sugiyama ARHGAP12 SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6 T231 Sugiyama ARHGAP12 QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IWX8 S817 Sugiyama CHERP DAN26 SCAF6 QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8IZ21 S118 Sugiyama PHACTR4 PRO2963 PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8ND56 S183 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A GSAFTQDTRsLKtQLsQGRssPQLDPLRKsPtMEQAVQtAs
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TEW0 S962 Sugiyama PARD3 PAR3 PAR3A DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q8WXI9 S122 Sugiyama GATAD2B KIAA1150 DEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSsRM
Q8WXI9 T120 Sugiyama GATAD2B KIAA1150 INDEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSs
Q8WY36 S844 Sugiyama BBX HBP2 KRKARKTKITHLVRtADGRVsPAGGTLDDKPKEQLQRSLPK
Q96B36 S212 Sugiyama AKT1S1 PRAS40 GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96G74 S64 Sugiyama OTUD5 GVGGGDRDRDsGVVGARPRAsPPPQGPLPGPPGALHRWALA
Q96MH2 S76 Sugiyama HEXIM2 L3 EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96MH2 T74 Sugiyama HEXIM2 L3 EDEDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRR
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2 S672 Sugiyama TNKS1BP1 KIAA1741 TAB182 TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H2X6 S364 Sugiyama HIPK2 VIDFGSAsHVSKAVCstyLQsRYyRAPEIILGLPFCEAIDM
Q9H2X6 Y361 Sugiyama HIPK2 RVKVIDFGSAsHVSKAVCstyLQsRYyRAPEIILGLPFCEA
Q9HC35 S144 Sugiyama EML4 C2orf2 EMAPL4 GQREKKEEsHsNDQsPQIRAsPsPQPssQPLQIHRQtPEsK
Q9HC35 S146 Sugiyama EML4 C2orf2 EMAPL4 REKKEEsHsNDQsPQIRAsPsPQPssQPLQIHRQtPEsKNA
Q9NPI6 S523 Sugiyama DCP1A SMIF APSVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILS
Q9P265 T71 Sugiyama DIP2B KIAA1463 PysPQTQETDSAVQKELRNQtPAPsAAQtsAPsKYHRTRSG
Q9UER7 S668 SIGNOR DAXX BING2 DAP6 YVERQRSVHEKNGKKICtLPsPPsPLAsLAPVADsstRVDs
Q9UGI8 S214 Sugiyama TES LPCEMDAQGPKQMNIPGGDRstPAAVGAMEDKSAEHKRTQY
Q9UMZ2 S1087 Sugiyama SYNRG AP1GBP1 SYNG QGSHKRsLsLGDKEIsRssPsPALEQPFRDRsNtLNEKPAL
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35 S323 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 RGEGDAPFsEPGttstQRPssPEtAtKQPssPYEDKDKDKK
Q9UQ35 T318 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 PAsGRRGEGDAPFsEPGttstQRPssPEtAtKQPssPYEDK
Q9UQ35 T328 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APFsEPGttstQRPssPEtAtKQPssPYEDKDKDKKEKsAt
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2U5 S163 Sugiyama MAP3K2 MAPKKK2 MEKK2 VFGAERKKRLsIIGPTSRDRssPPPGYIPDELHQVARNGSF
Q9Y2U5 S164 Sugiyama MAP3K2 MAPKKK2 MEKK2 FGAERKKRLsIIGPTSRDRssPPPGYIPDELHQVARNGSFT
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 9.178136e-11 10.037 0 0
Chromatin modifying enzymes R-HSA-3247509 4.336468e-10 9.363 0 0
Cell Cycle R-HSA-1640170 3.422963e-08 7.466 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.174998e-07 6.209 0 0
NRAGE signals death through JNK R-HSA-193648 6.314494e-07 6.200 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.420845e-07 6.075 0 0
Cell Cycle, Mitotic R-HSA-69278 8.465484e-07 6.072 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.299718e-06 5.886 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.462928e-06 5.835 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.811691e-06 5.419 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.268237e-06 5.486 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.993780e-06 5.399 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.864063e-06 5.232 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.864063e-06 5.232 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.176240e-06 5.209 0 0
Gene expression (Transcription) R-HSA-74160 6.331404e-06 5.198 1 0
Nuclear import of Rev protein R-HSA-180746 7.629958e-06 5.117 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.728562e-06 5.112 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.061147e-05 4.974 0 0
Regulation of TP53 Activity R-HSA-5633007 1.627483e-05 4.788 1 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.777138e-05 4.750 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.988581e-05 4.701 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.493304e-05 4.603 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.493304e-05 4.603 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.569757e-05 4.447 0 0
Mitotic Prophase R-HSA-68875 4.257313e-05 4.371 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.732390e-05 4.325 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.746482e-05 4.324 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.746482e-05 4.324 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.410205e-05 4.193 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.436019e-05 4.074 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.045142e-04 3.981 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.103416e-04 3.957 0 0
Cellular Senescence R-HSA-2559583 1.188799e-04 3.925 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.223633e-04 3.912 1 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.510340e-04 3.821 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.537794e-04 3.813 0 0
RNA Polymerase II Transcription R-HSA-73857 1.595522e-04 3.797 1 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.713152e-04 3.766 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.663095e-04 3.779 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.841254e-04 3.735 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.089702e-04 3.680 0 0
HATs acetylate histones R-HSA-3214847 2.274028e-04 3.643 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.752059e-04 3.560 0 0
M Phase R-HSA-68886 3.001216e-04 3.523 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.921447e-04 3.308 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.655146e-04 3.248 0 0
G alpha (12/13) signalling events R-HSA-416482 5.655146e-04 3.248 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.003102e-04 3.222 0 0
Cell Cycle Checkpoints R-HSA-69620 6.592900e-04 3.181 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 7.294296e-04 3.137 0 0
Apoptotic execution phase R-HSA-75153 7.173473e-04 3.144 0 0
Signaling by NTRKs R-HSA-166520 7.088665e-04 3.149 0 0
Death Receptor Signaling R-HSA-73887 7.511649e-04 3.124 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.728882e-04 3.112 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.238485e-04 3.084 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 9.850343e-04 3.007 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.021875e-03 2.991 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.056452e-03 2.976 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.072215e-03 2.970 0 0
Circadian clock R-HSA-9909396 1.081472e-03 2.966 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.180761e-03 2.928 0 0
Generic Transcription Pathway R-HSA-212436 1.228463e-03 2.911 1 0
RUNX2 regulates bone development R-HSA-8941326 1.236623e-03 2.908 0 0
Metabolism of non-coding RNA R-HSA-194441 1.405094e-03 2.852 0 0
snRNP Assembly R-HSA-191859 1.405094e-03 2.852 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.344507e-03 2.871 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.632594e-03 2.787 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.632594e-03 2.787 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.632594e-03 2.787 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.559781e-03 2.807 0 0
Polo-like kinase mediated events R-HSA-156711 1.644735e-03 2.784 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.576842e-03 2.802 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.576842e-03 2.802 0 0
mRNA Splicing R-HSA-72172 1.489870e-03 2.827 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.591520e-03 2.798 0 0
Signaling by ALK in cancer R-HSA-9700206 1.591520e-03 2.798 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.483438e-03 2.829 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.664750e-03 2.779 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.689126e-03 2.772 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.797592e-03 2.745 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.194621e-03 2.659 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.286224e-03 2.641 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.338864e-03 2.631 0 0
Regulation of TP53 Expression R-HSA-6804754 2.492174e-03 2.603 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.576601e-03 2.589 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.526886e-03 2.597 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.508542e-03 2.601 0 0
NGF-stimulated transcription R-HSA-9031628 2.595147e-03 2.586 0 0
Cellular response to heat stress R-HSA-3371556 2.891042e-03 2.539 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.971611e-03 2.527 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.053046e-03 2.515 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.161590e-03 2.500 0 0
G2/M Transition R-HSA-69275 3.498931e-03 2.456 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.683272e-03 2.434 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.693510e-03 2.433 0 0
Kinesins R-HSA-983189 3.693510e-03 2.433 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.789423e-03 2.421 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.063276e-03 2.391 0 0
Gastrulation R-HSA-9758941 4.288794e-03 2.368 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.297634e-03 2.367 0 0
HDMs demethylate histones R-HSA-3214842 4.603394e-03 2.337 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.700772e-03 2.328 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.981133e-03 2.303 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.039035e-03 2.298 0 0
HIV Life Cycle R-HSA-162587 5.258362e-03 2.279 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.500014e-03 2.260 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.143208e-03 2.212 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.983649e-03 2.156 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.060519e-03 2.151 0 0
Signaling by LTK R-HSA-9842663 7.564843e-03 2.121 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.628087e-03 2.118 0 0
Deubiquitination R-HSA-5688426 7.661895e-03 2.116 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.699500e-03 2.114 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 8.687569e-03 2.061 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 8.687569e-03 2.061 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 8.687569e-03 2.061 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.665106e-03 2.062 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 8.867684e-03 2.052 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.972408e-03 2.047 0 0
Adipogenesis R-HSA-9843745 9.439717e-03 2.025 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.017517e-02 1.992 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.029800e-02 1.987 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.791478e-03 2.009 0 0
DNA Double Strand Break Response R-HSA-5693606 9.865586e-03 2.006 0 0
Ovarian tumor domain proteases R-HSA-5689896 9.563362e-03 2.019 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 9.563362e-03 2.019 0 0
tRNA processing in the nucleus R-HSA-6784531 1.026002e-02 1.989 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.062152e-02 1.974 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.068663e-02 1.971 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.083236e-02 1.965 0 0
mRNA 3'-end processing R-HSA-72187 1.093382e-02 1.961 0 0
Homology Directed Repair R-HSA-5693538 1.158045e-02 1.936 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.169072e-02 1.932 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.169072e-02 1.932 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.344247e-02 1.872 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.344247e-02 1.872 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.301721e-02 1.885 0 0
Centrosome maturation R-HSA-380287 1.354503e-02 1.868 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.301721e-02 1.885 0 0
Glycolysis R-HSA-70171 1.375464e-02 1.862 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.418389e-02 1.848 0 0
Signal Transduction R-HSA-162582 1.435682e-02 1.843 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.498173e-02 1.824 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.503900e-02 1.823 1 1
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.512155e-02 1.820 0 0
Signaling by NOTCH1 R-HSA-1980143 1.518483e-02 1.819 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.621039e-02 1.790 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.694337e-02 1.771 0 0
Notch-HLH transcription pathway R-HSA-350054 1.748110e-02 1.757 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.818801e-02 1.740 0 0
NrCAM interactions R-HSA-447038 1.694337e-02 1.771 0 0
G1/S-Specific Transcription R-HSA-69205 1.848935e-02 1.733 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.731845e-02 1.761 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.854580e-02 1.732 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.861868e-02 1.730 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.916203e-02 1.718 0 0
MET receptor recycling R-HSA-8875656 1.938770e-02 1.712 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.005696e-02 1.698 0 0
Specification of the neural plate border R-HSA-9834899 2.005696e-02 1.698 0 0
Heme signaling R-HSA-9707616 2.013016e-02 1.696 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.130420e-02 1.672 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.184313e-02 1.661 0 0
Cardiogenesis R-HSA-9733709 2.188716e-02 1.660 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.188716e-02 1.660 0 0
Mitotic Prometaphase R-HSA-68877 2.236988e-02 1.650 0 0
Repression of WNT target genes R-HSA-4641265 2.521549e-02 1.598 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.474618e-02 1.606 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.474618e-02 1.606 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.474618e-02 1.606 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.474618e-02 1.606 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.362166e-02 1.627 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.521549e-02 1.598 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.591628e-02 1.586 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.599528e-02 1.585 0 0
Inositol phosphate metabolism R-HSA-1483249 2.649657e-02 1.577 0 0
Signaling by TGFB family members R-HSA-9006936 2.668453e-02 1.574 0 0
G2/M Checkpoints R-HSA-69481 2.697930e-02 1.569 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.819463e-02 1.550 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.173972e-02 1.498 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.173972e-02 1.498 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.852151e-02 1.545 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.050618e-02 1.516 0 0
RAF activation R-HSA-5673000 2.985966e-02 1.525 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.018295e-02 1.520 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.034218e-02 1.518 0 0
TGFBR3 expression R-HSA-9839394 3.068705e-02 1.513 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.120866e-02 1.506 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.985966e-02 1.525 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.034218e-02 1.518 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.159053e-02 1.500 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.852151e-02 1.545 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.985966e-02 1.525 0 0
Gene Silencing by RNA R-HSA-211000 2.852727e-02 1.545 0 0
Formation of axial mesoderm R-HSA-9796292 3.242425e-02 1.489 0 0
MET interacts with TNS proteins R-HSA-8875513 3.290404e-02 1.483 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.290404e-02 1.483 0 0
Signaling by Hippo R-HSA-2028269 3.523503e-02 1.453 0 0
Specification of primordial germ cells R-HSA-9827857 3.523503e-02 1.453 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.631768e-02 1.440 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.631768e-02 1.440 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.631768e-02 1.440 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.747078e-02 1.426 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.747078e-02 1.426 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.754548e-02 1.425 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.785164e-02 1.422 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.140756e-02 1.383 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.140756e-02 1.383 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.134849e-02 1.384 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.291844e-02 1.367 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.085259e-02 1.389 1 1
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.841568e-02 1.415 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.992001e-02 1.399 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.327974e-02 1.364 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.189177e-02 1.378 0 0
Mitotic Anaphase R-HSA-68882 4.428682e-02 1.354 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.596448e-02 1.338 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.596448e-02 1.338 0 0
Formation of the posterior neural plate R-HSA-9832991 4.663507e-02 1.331 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.672526e-02 1.330 0 0
Nuclear RNA decay R-HSA-9930044 4.765014e-02 1.322 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.765014e-02 1.322 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.765014e-02 1.322 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.054721e-02 1.296 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.054721e-02 1.296 0 0
Formation of the anterior neural plate R-HSA-9823739 5.054721e-02 1.296 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.124452e-02 1.290 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.142543e-02 1.289 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.142543e-02 1.289 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.148801e-02 1.288 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.148801e-02 1.288 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.148801e-02 1.288 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.148801e-02 1.288 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.160825e-02 1.287 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.163330e-02 1.287 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.277983e-02 1.278 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.908357e-02 1.229 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.153659e-02 1.211 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.153659e-02 1.211 0 0
Negative regulation of MET activity R-HSA-6807004 6.133003e-02 1.212 0 0
Formation of definitive endoderm R-HSA-9823730 6.133003e-02 1.212 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.776952e-02 1.238 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.776952e-02 1.238 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.846454e-02 1.233 0 0
DNA Repair R-HSA-73894 6.437629e-02 1.191 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.840681e-02 1.234 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.211319e-02 1.207 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.527549e-02 1.185 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 6.531880e-02 1.185 0 0
Interleukin-37 signaling R-HSA-9008059 6.577698e-02 1.182 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.730259e-02 1.172 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.783856e-02 1.169 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.783856e-02 1.169 0 0
Type I hemidesmosome assembly R-HSA-446107 6.783856e-02 1.169 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.783856e-02 1.169 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.783856e-02 1.169 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.783856e-02 1.169 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.796003e-02 1.168 0 0
Signaling by MET R-HSA-6806834 6.806392e-02 1.167 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.806392e-02 1.167 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.921394e-02 1.160 0 0
Long-term potentiation R-HSA-9620244 6.921394e-02 1.160 0 0
Glucose metabolism R-HSA-70326 6.998334e-02 1.155 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.030321e-02 1.153 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.283954e-02 1.138 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.324424e-02 1.135 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.324424e-02 1.135 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.383083e-02 1.132 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 7.409851e-02 1.130 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 7.409851e-02 1.130 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 7.409851e-02 1.130 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 7.409851e-02 1.130 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 7.409851e-02 1.130 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.608190e-02 1.119 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.608190e-02 1.119 0 0
Signaling by TGFBR3 R-HSA-9839373 7.608190e-02 1.119 0 0
Diseases of DNA repair R-HSA-9675135 7.608190e-02 1.119 0 0
ALK mutants bind TKIs R-HSA-9700645 8.662383e-02 1.062 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.908634e-02 1.050 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.908634e-02 1.050 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.742210e-02 1.058 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.435396e-02 1.025 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.435396e-02 1.025 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.435396e-02 1.025 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.435396e-02 1.025 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.435396e-02 1.025 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.683917e-02 1.061 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 8.561404e-02 1.067 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.391542e-02 1.076 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.908634e-02 1.050 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.662383e-02 1.062 0 0
Frs2-mediated activation R-HSA-170968 8.908634e-02 1.050 0 0
RET signaling R-HSA-8853659 7.914478e-02 1.102 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.662383e-02 1.062 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.120219e-02 1.040 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.880455e-02 1.052 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.560182e-02 1.020 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.560182e-02 1.020 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.560182e-02 1.020 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.677384e-02 1.014 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.677384e-02 1.014 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.677384e-02 1.014 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.994923e-02 1.000 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.003241e-01 0.999 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.003241e-01 0.999 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.003241e-01 0.999 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.003241e-01 0.999 0 0
Phosphorylation of Emi1 R-HSA-176417 1.003241e-01 0.999 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.003241e-01 0.999 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.003241e-01 0.999 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.003241e-01 0.999 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.008523e-01 0.996 0 0
PTEN Regulation R-HSA-6807070 1.012148e-01 0.995 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.022855e-01 0.990 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.022855e-01 0.990 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.022855e-01 0.990 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.022855e-01 0.990 0 0
Signaling by NOTCH R-HSA-157118 1.023402e-01 0.990 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.063284e-01 0.973 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.063284e-01 0.973 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.063284e-01 0.973 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.063284e-01 0.973 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.063284e-01 0.973 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.063284e-01 0.973 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.063284e-01 0.973 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.063284e-01 0.973 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.063284e-01 0.973 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.063284e-01 0.973 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.063284e-01 0.973 0 0
Pexophagy R-HSA-9664873 1.076407e-01 0.968 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.076407e-01 0.968 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.065508e-01 0.972 0 0
Erythropoietin activates RAS R-HSA-9027284 1.255536e-01 0.901 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.183801e-01 0.927 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.029755e-01 0.987 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.029755e-01 0.987 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.255280e-01 0.901 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.070388e-01 0.970 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.070388e-01 0.970 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.210508e-01 0.917 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.210508e-01 0.917 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.210508e-01 0.917 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.213037e-01 0.916 0 0
Transcription of the HIV genome R-HSA-167172 1.107827e-01 0.956 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.204283e-01 0.919 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.204283e-01 0.919 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.204283e-01 0.919 0 0
Signal attenuation R-HSA-74749 1.076407e-01 0.968 0 0
Signaling by EGFR R-HSA-177929 1.118547e-01 0.951 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.070388e-01 0.970 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.210508e-01 0.917 0 0
RMTs methylate histone arginines R-HSA-3214858 1.110820e-01 0.954 0 0
Apoptosis R-HSA-109581 1.281612e-01 0.892 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.159547e-01 0.936 0 0
Cell junction organization R-HSA-446728 1.241467e-01 0.906 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.166383e-01 0.933 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.076407e-01 0.968 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.288935e-01 0.890 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.288935e-01 0.890 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.288935e-01 0.890 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.288935e-01 0.890 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.288935e-01 0.890 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.296721e-01 0.887 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.296721e-01 0.887 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.307061e-01 0.884 0 0
Signalling to ERKs R-HSA-187687 1.320995e-01 0.879 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.327203e-01 0.877 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.378619e-01 0.861 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.383080e-01 0.859 0 0
Metabolism of RNA R-HSA-8953854 1.412827e-01 0.850 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.413560e-01 0.850 0 0
Interleukin-7 signaling R-HSA-1266695 1.413560e-01 0.850 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.439527e-01 0.842 0 0
EGFR downregulation R-HSA-182971 1.443843e-01 0.840 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.443843e-01 0.840 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.458295e-01 0.836 0 0
HIV Transcription Initiation R-HSA-167161 1.458295e-01 0.836 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.458295e-01 0.836 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.458295e-01 0.836 0 0
Differentiation of T cells R-HSA-9945266 1.459897e-01 0.836 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.459897e-01 0.836 0 0
Phosphorylation of the APC/C R-HSA-176412 1.459897e-01 0.836 0 0
Prolonged ERK activation events R-HSA-169893 1.459897e-01 0.836 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.482612e-01 0.829 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.517589e-01 0.819 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.522968e-01 0.817 0 0
Invadopodia formation R-HSA-8941237 1.522968e-01 0.817 0 0
MET activates PTPN11 R-HSA-8865999 1.522968e-01 0.817 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.556056e-01 0.808 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 1.556056e-01 0.808 0 0
Activation of RAC1 R-HSA-428540 1.556056e-01 0.808 0 0
Signaling by AXIN mutants R-HSA-4839735 1.556056e-01 0.808 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.556056e-01 0.808 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.580912e-01 0.801 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.591230e-01 0.798 0 0
Signaling by WNT in cancer R-HSA-4791275 1.597723e-01 0.796 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.599447e-01 0.796 0 0
HCN channels R-HSA-1296061 2.012657e-01 0.696 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.012657e-01 0.696 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.012657e-01 0.696 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.012657e-01 0.696 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.012657e-01 0.696 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.012657e-01 0.696 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.616120e-01 0.792 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.616120e-01 0.792 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.616120e-01 0.792 0 0
Regulation of PTEN localization R-HSA-8948747 1.616120e-01 0.792 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.616120e-01 0.792 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.616120e-01 0.792 0 0
SOS-mediated signalling R-HSA-112412 1.616120e-01 0.792 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.956064e-01 0.709 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.821034e-01 0.740 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.821034e-01 0.740 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.821034e-01 0.740 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.677369e-01 0.775 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.677369e-01 0.775 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.677369e-01 0.775 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.099512e-01 0.678 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.146137e-01 0.668 0 0
PKA activation in glucagon signalling R-HSA-164378 2.146137e-01 0.668 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.756788e-01 0.755 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.756788e-01 0.755 0 0
HIV elongation arrest and recovery R-HSA-167287 1.940574e-01 0.712 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.940574e-01 0.712 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.729895e-01 0.762 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.064299e-01 0.685 0 0
HDACs deacetylate histones R-HSA-3214815 1.678683e-01 0.775 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.023334e-01 0.694 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.717902e-01 0.765 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.815673e-01 0.741 0 0
HIV Transcription Elongation R-HSA-167169 2.064299e-01 0.685 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.094930e-01 0.679 0 0
Neurexins and neuroligins R-HSA-6794361 2.124200e-01 0.673 0 0
mTORC1-mediated signalling R-HSA-166208 1.937862e-01 0.713 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.064299e-01 0.685 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.756788e-01 0.755 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.748448e-01 0.757 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.903524e-01 0.720 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.917570e-01 0.717 0 0
S Phase R-HSA-69242 1.663353e-01 0.779 0 0
Cyclin D associated events in G1 R-HSA-69231 1.874028e-01 0.727 0 0
G1 Phase R-HSA-69236 1.874028e-01 0.727 0 0
G1/S Transition R-HSA-69206 1.683901e-01 0.774 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.756788e-01 0.755 0 0
TBC/RABGAPs R-HSA-8854214 1.729895e-01 0.762 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.734372e-01 0.761 0 0
HIV Infection R-HSA-162906 1.737404e-01 0.760 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.758911e-01 0.755 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.956064e-01 0.709 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.616120e-01 0.792 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.411799e-01 0.618 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.411799e-01 0.618 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.411799e-01 0.618 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.411799e-01 0.618 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.411799e-01 0.618 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.411799e-01 0.618 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.411799e-01 0.618 0 0
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9036092 2.411799e-01 0.618 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.411799e-01 0.618 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.389982e-01 0.470 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.389982e-01 0.470 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.389982e-01 0.470 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.389982e-01 0.470 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.389982e-01 0.470 0 0
Defective SLC9A9 causes autism 16 (AUTS16) R-HSA-5619052 3.389982e-01 0.470 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.389982e-01 0.470 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.389982e-01 0.470 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.389982e-01 0.470 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.389982e-01 0.470 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.389982e-01 0.470 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.389982e-01 0.470 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.389982e-01 0.470 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.516987e-01 0.599 0 0
IRS activation R-HSA-74713 2.516987e-01 0.599 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.516987e-01 0.599 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.311340e-01 0.636 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.311340e-01 0.636 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.024056e-01 0.519 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.024056e-01 0.519 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.024056e-01 0.519 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.024056e-01 0.519 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.024056e-01 0.519 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.024056e-01 0.519 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.024056e-01 0.519 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.242118e-01 0.372 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.242118e-01 0.372 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.242118e-01 0.372 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.242118e-01 0.372 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.242118e-01 0.372 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.242118e-01 0.372 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.242118e-01 0.372 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.677042e-01 0.572 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.677042e-01 0.572 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.524782e-01 0.453 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.524782e-01 0.453 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.048669e-01 0.516 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.048669e-01 0.516 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.048669e-01 0.516 0 0
Signaling by APC mutants R-HSA-4839744 3.048669e-01 0.516 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.048669e-01 0.516 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.048669e-01 0.516 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.048669e-01 0.516 0 0
Regulation of signaling by CBL R-HSA-912631 2.394473e-01 0.621 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.394473e-01 0.621 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.149812e-01 0.668 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.650069e-01 0.577 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.422178e-01 0.466 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.422178e-01 0.466 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.422178e-01 0.466 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.422178e-01 0.466 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.012379e-01 0.397 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.012379e-01 0.397 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 4.012379e-01 0.397 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.984443e-01 0.302 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.984443e-01 0.302 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.984443e-01 0.302 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.984443e-01 0.302 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 4.984443e-01 0.302 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.984443e-01 0.302 0 0
Activation of the pre-replicative complex R-HSA-68962 2.329151e-01 0.633 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.911388e-01 0.536 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.911388e-01 0.536 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.298519e-01 0.482 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.826207e-01 0.549 0 0
MET activates RAS signaling R-HSA-8851805 3.794013e-01 0.421 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.794013e-01 0.421 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.794013e-01 0.421 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.794013e-01 0.421 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.794013e-01 0.421 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.794013e-01 0.421 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.467126e-01 0.608 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.177495e-01 0.662 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.177495e-01 0.662 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.177495e-01 0.662 0 0
G0 and Early G1 R-HSA-1538133 2.740805e-01 0.562 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.401292e-01 0.620 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.481912e-01 0.349 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.445183e-01 0.463 0 0
MET promotes cell motility R-HSA-8875878 2.851605e-01 0.545 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.161101e-01 0.381 0 0
PKA activation R-HSA-163615 3.916472e-01 0.407 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.714787e-01 0.430 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.714787e-01 0.430 0 0
Signaling by Erythropoietin R-HSA-9006335 3.541252e-01 0.451 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.853446e-01 0.545 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.452772e-01 0.462 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.452772e-01 0.462 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.984401e-01 0.400 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.222922e-01 0.374 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.929937e-01 0.307 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.631103e-01 0.249 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.631103e-01 0.249 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.631103e-01 0.249 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.631103e-01 0.249 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.361564e-01 0.473 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.657214e-01 0.437 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.525443e-01 0.344 0 0
Separation of Sister Chromatids R-HSA-2467813 2.427739e-01 0.615 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 4.871079e-01 0.312 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.871079e-01 0.312 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.871079e-01 0.312 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.871079e-01 0.312 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.871079e-01 0.312 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.518794e-01 0.345 0 0
DNA replication initiation R-HSA-68952 5.354196e-01 0.271 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.354196e-01 0.271 0 0
HSF1-dependent transactivation R-HSA-3371571 4.271924e-01 0.369 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.781387e-01 0.320 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.781387e-01 0.320 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.087702e-01 0.389 0 0
Nucleosome assembly R-HSA-774815 4.479379e-01 0.349 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.479379e-01 0.349 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.464358e-01 0.350 0 0
Meiotic synapsis R-HSA-1221632 4.655908e-01 0.332 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.655908e-01 0.332 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.292676e-01 0.276 0 0
DNA methylation R-HSA-5334118 5.292676e-01 0.276 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.536449e-01 0.257 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.753371e-01 0.240 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.194421e-01 0.208 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.194421e-01 0.208 0 0
G2 Phase R-HSA-68911 6.194421e-01 0.208 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.194421e-01 0.208 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.194421e-01 0.208 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.194421e-01 0.208 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.437717e-01 0.265 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.539806e-01 0.257 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.539806e-01 0.257 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.670216e-01 0.246 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.659546e-01 0.247 0 0
HCMV Early Events R-HSA-9609690 5.741033e-01 0.241 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.935171e-01 0.227 0 0
Deadenylation of mRNA R-HSA-429947 5.935171e-01 0.227 0 0
ERKs are inactivated R-HSA-202670 6.126878e-01 0.213 0 0
Ephrin signaling R-HSA-3928664 6.147559e-01 0.211 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.147559e-01 0.211 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.190256e-01 0.208 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.291465e-01 0.201 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.929760e-01 0.406 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.065669e-01 0.513 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.923918e-01 0.406 0 0
Signaling by NOTCH3 R-HSA-9012852 2.580177e-01 0.588 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.298519e-01 0.482 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.916472e-01 0.407 0 0
Nucleotide Excision Repair R-HSA-5696398 5.479295e-01 0.261 0 0
Signaling by ERBB2 R-HSA-1227986 4.630387e-01 0.334 0 0
mRNA Capping R-HSA-72086 5.292676e-01 0.276 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.853446e-01 0.545 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.525443e-01 0.344 0 0
Regulation of CDH11 function R-HSA-9762292 5.354196e-01 0.271 0 0
GPER1 signaling R-HSA-9634597 5.085474e-01 0.294 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.614025e-01 0.251 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.794013e-01 0.421 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.794013e-01 0.421 0 0
RNA Polymerase III Transcription R-HSA-74158 2.467126e-01 0.608 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.387911e-01 0.470 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.520842e-01 0.345 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.539806e-01 0.257 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.849189e-01 0.233 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.156693e-01 0.211 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.066603e-01 0.391 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.422178e-01 0.466 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.929937e-01 0.307 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.354196e-01 0.271 0 0
Interleukin-15 signaling R-HSA-8983432 3.794013e-01 0.421 0 0
Signaling by BMP R-HSA-201451 3.061667e-01 0.514 0 0
DAP12 signaling R-HSA-2424491 3.783342e-01 0.422 0 0
IGF1R signaling cascade R-HSA-2428924 4.088156e-01 0.388 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.665571e-01 0.574 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.665571e-01 0.574 0 0
UCH proteinases R-HSA-5689603 3.772335e-01 0.423 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.147559e-01 0.211 0 0
Meiosis R-HSA-1500620 4.085226e-01 0.389 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.868103e-01 0.232 0 0
PI3K/AKT activation R-HSA-198203 2.677042e-01 0.572 0 0
Signaling by Activin R-HSA-1502540 2.686890e-01 0.571 0 0
Formation of apoptosome R-HSA-111458 5.354196e-01 0.271 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.633124e-01 0.580 0 0
RNA Polymerase I Transcription R-HSA-73864 2.155579e-01 0.666 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.521598e-01 0.345 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.292676e-01 0.276 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.539806e-01 0.257 0 0
Hedgehog 'off' state R-HSA-5610787 4.644098e-01 0.333 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.422178e-01 0.466 0 0
Signaling by RAS mutants R-HSA-6802949 2.177495e-01 0.662 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.631051e-01 0.249 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.329151e-01 0.633 0 0
p75NTR signals via NF-kB R-HSA-193639 4.871079e-01 0.312 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.210070e-01 0.283 0 0
Hedgehog 'on' state R-HSA-5632684 3.002212e-01 0.523 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.389982e-01 0.470 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.714787e-01 0.430 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.929937e-01 0.307 0 0
Regulation of gap junction activity R-HSA-191650 5.631103e-01 0.249 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.871079e-01 0.312 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.781387e-01 0.320 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.404099e-01 0.356 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.835961e-01 0.547 0 0
Activation of BH3-only proteins R-HSA-114452 2.329151e-01 0.633 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.261168e-01 0.370 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.631636e-01 0.440 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.507454e-01 0.346 0 0
MTOR signalling R-HSA-165159 2.576618e-01 0.589 0 0
Rap1 signalling R-HSA-392517 2.394473e-01 0.621 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.088813e-01 0.388 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.980003e-01 0.303 0 0
Integration of provirus R-HSA-162592 6.126878e-01 0.213 0 0
Apoptotic factor-mediated response R-HSA-111471 6.147559e-01 0.211 0 0
TNF signaling R-HSA-75893 3.903122e-01 0.409 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.518794e-01 0.345 0 0
Cilium Assembly R-HSA-5617833 3.010078e-01 0.521 0 0
Meiotic recombination R-HSA-912446 5.668581e-01 0.247 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.343051e-01 0.198 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.532974e-01 0.596 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.620002e-01 0.335 0 0
Signaling by Hedgehog R-HSA-5358351 4.760750e-01 0.322 0 0
Semaphorin interactions R-HSA-373755 5.166612e-01 0.287 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.369217e-01 0.625 0 0
Neurodegenerative Diseases R-HSA-8863678 2.369217e-01 0.625 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.516987e-01 0.599 0 0
Calcineurin activates NFAT R-HSA-2025928 2.311340e-01 0.636 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.520842e-01 0.345 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.520842e-01 0.345 0 0
Signaling by NODAL R-HSA-1181150 4.525443e-01 0.344 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.194421e-01 0.208 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.194421e-01 0.208 0 0
Defective pyroptosis R-HSA-9710421 5.560790e-01 0.255 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.143375e-01 0.289 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.452967e-01 0.610 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.395761e-01 0.621 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.549907e-01 0.256 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.312274e-01 0.480 0 0
Signaling by FGFR4 R-HSA-5654743 5.560790e-01 0.255 0 0
Oncogene Induced Senescence R-HSA-2559585 3.608364e-01 0.443 0 0
Interleukin-2 signaling R-HSA-9020558 5.753371e-01 0.240 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.441478e-01 0.463 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.985906e-01 0.302 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.422312e-01 0.616 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.964286e-01 0.402 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.575891e-01 0.254 0 0
Diseases of programmed cell death R-HSA-9645723 3.644537e-01 0.438 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.239882e-01 0.205 0 0
Axon guidance R-HSA-422475 4.291334e-01 0.367 0 0
Nervous system development R-HSA-9675108 3.926637e-01 0.406 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.407503e-01 0.618 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.310558e-01 0.480 0 0
Signaling by FGFR3 R-HSA-5654741 5.961600e-01 0.225 0 0
Programmed Cell Death R-HSA-5357801 3.203319e-01 0.494 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 3.024056e-01 0.519 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.984443e-01 0.302 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.631103e-01 0.249 0 0
Ub-specific processing proteases R-HSA-5689880 2.714362e-01 0.566 0 0
Rab regulation of trafficking R-HSA-9007101 3.555227e-01 0.449 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.745257e-01 0.324 0 0
Reproduction R-HSA-1474165 4.539390e-01 0.343 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.025670e-01 0.395 0 0
Mitochondrial biogenesis R-HSA-1592230 3.555227e-01 0.449 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.648635e-01 0.577 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.166612e-01 0.287 0 0
Neurofascin interactions R-HSA-447043 3.524782e-01 0.453 0 0
ERK/MAPK targets R-HSA-198753 2.911388e-01 0.536 0 0
Myogenesis R-HSA-525793 2.826207e-01 0.549 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.049353e-01 0.516 0 0
Vasopressin-like receptors R-HSA-388479 5.631103e-01 0.249 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.903122e-01 0.409 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.822592e-01 0.317 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.929500e-01 0.307 0 0
Recycling pathway of L1 R-HSA-437239 4.885437e-01 0.311 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.346529e-01 0.630 0 0
Membrane Trafficking R-HSA-199991 3.234428e-01 0.490 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.140387e-01 0.212 0 0
Signaling by VEGF R-HSA-194138 4.684829e-01 0.329 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.607730e-01 0.443 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.607730e-01 0.443 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.140387e-01 0.212 0 0
Cell-cell junction organization R-HSA-421270 4.176233e-01 0.379 0 0
Adherens junctions interactions R-HSA-418990 3.122008e-01 0.506 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.210070e-01 0.283 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.935171e-01 0.227 0 0
Cellular responses to stress R-HSA-2262752 5.932241e-01 0.227 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.479295e-01 0.261 0 0
Interleukin-2 family signaling R-HSA-451927 6.291465e-01 0.201 0 0
Post NMDA receptor activation events R-HSA-438064 4.541400e-01 0.343 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.714362e-01 0.566 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.714362e-01 0.566 0 0
Cell-Cell communication R-HSA-1500931 2.199096e-01 0.658 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.435045e-01 0.191 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.822592e-01 0.317 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.822592e-01 0.317 0 0
ESR-mediated signaling R-HSA-8939211 4.199394e-01 0.377 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.011585e-01 0.221 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.411799e-01 0.618 0 0
SDK interactions R-HSA-373756 2.411799e-01 0.618 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.389982e-01 0.470 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.516987e-01 0.599 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.242118e-01 0.372 0 0
C6 deamination of adenosine R-HSA-75102 4.242118e-01 0.372 0 0
TGFBR3 regulates activin signaling R-HSA-9839406 4.242118e-01 0.372 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.242118e-01 0.372 0 0
Regulation of KIT signaling R-HSA-1433559 2.388967e-01 0.622 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.048669e-01 0.516 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.422178e-01 0.466 0 0
MET activates STAT3 R-HSA-8875791 4.984443e-01 0.302 0 0
Sodium/Proton exchangers R-HSA-425986 4.481912e-01 0.349 0 0
Unwinding of DNA R-HSA-176974 4.929937e-01 0.307 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.631103e-01 0.249 0 0
Metalloprotease DUBs R-HSA-5689901 4.518794e-01 0.345 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.210070e-01 0.283 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.360780e-01 0.360 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.194421e-01 0.208 0 0
Reelin signalling pathway R-HSA-8866376 6.194421e-01 0.208 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 5.849189e-01 0.233 0 0
MAPK family signaling cascades R-HSA-5683057 6.116644e-01 0.213 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.880959e-01 0.231 0 0
NF-kB is activated and signals survival R-HSA-209560 6.126878e-01 0.213 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.564469e-01 0.255 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.360780e-01 0.360 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.360780e-01 0.360 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.925834e-01 0.308 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.951672e-01 0.225 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.176915e-01 0.498 0 0
HCMV Late Events R-HSA-9610379 5.396018e-01 0.268 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.520842e-01 0.345 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.677042e-01 0.572 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.794013e-01 0.421 0 0
Downstream signal transduction R-HSA-186763 4.025670e-01 0.395 0 0
Calmodulin induced events R-HSA-111933 3.829912e-01 0.417 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.170961e-01 0.286 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.517404e-01 0.258 0 0
TRP channels R-HSA-3295583 6.435045e-01 0.191 0 0
DCC mediated attractive signaling R-HSA-418885 2.686890e-01 0.571 0 0
CaM pathway R-HSA-111997 3.829912e-01 0.417 0 0
Interferon Signaling R-HSA-913531 5.047640e-01 0.297 0 0
MAP kinase activation R-HSA-450294 4.810585e-01 0.318 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.481912e-01 0.349 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.631103e-01 0.249 0 0
Formation of intermediate mesoderm R-HSA-9761174 5.354196e-01 0.271 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.753371e-01 0.240 0 0
Interleukin-17 signaling R-HSA-448424 5.117552e-01 0.291 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.204649e-01 0.284 0 0
L1CAM interactions R-HSA-373760 5.259224e-01 0.279 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.337053e-01 0.198 0 0
FOXO-mediated transcription R-HSA-9614085 2.659029e-01 0.575 0 0
Ca-dependent events R-HSA-111996 5.353957e-01 0.271 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.061667e-01 0.514 0 0
PI Metabolism R-HSA-1483255 5.941933e-01 0.226 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.443370e-01 0.191 0 0
Signaling by PTK6 R-HSA-8848021 6.443370e-01 0.191 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.025290e-01 0.395 0 0
Tie2 Signaling R-HSA-210993 3.916472e-01 0.407 0 0
DAG and IP3 signaling R-HSA-1489509 5.961600e-01 0.225 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.911388e-01 0.536 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.124198e-01 0.505 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.389982e-01 0.470 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.677042e-01 0.572 0 0
Activation of SMO R-HSA-5635838 2.990847e-01 0.524 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.990847e-01 0.524 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.984443e-01 0.302 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.984443e-01 0.302 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 2.911388e-01 0.536 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 3.984401e-01 0.400 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.520842e-01 0.345 0 0
Sensory perception of sour taste R-HSA-9729555 5.631103e-01 0.249 0 0
NADE modulates death signalling R-HSA-205025 5.631103e-01 0.249 0 0
Disorders of Developmental Biology R-HSA-9675151 5.536449e-01 0.257 0 0
Synthesis of PI R-HSA-1483226 5.753371e-01 0.240 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.753371e-01 0.240 0 0
Integrin signaling R-HSA-354192 6.239882e-01 0.205 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.541252e-01 0.451 0 0
FLT3 signaling in disease R-HSA-9682385 2.467126e-01 0.608 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.856075e-01 0.232 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.311340e-01 0.636 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.871079e-01 0.312 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.017494e-01 0.221 0 0
Signaling by SCF-KIT R-HSA-1433557 5.560790e-01 0.255 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.871079e-01 0.312 0 0
Netrin-1 signaling R-HSA-373752 2.938563e-01 0.532 0 0
Signaling by ALK R-HSA-201556 3.049353e-01 0.516 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.242118e-01 0.372 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.990847e-01 0.524 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.012379e-01 0.397 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.012379e-01 0.397 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.984443e-01 0.302 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.607730e-01 0.443 0 0
Dopamine receptors R-HSA-390651 5.631103e-01 0.249 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.631103e-01 0.249 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.186905e-01 0.497 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.518794e-01 0.345 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.507454e-01 0.346 0 0
Bicarbonate transporters R-HSA-425381 5.753371e-01 0.240 0 0
Trafficking of AMPA receptors R-HSA-399719 5.780390e-01 0.238 0 0
Anchoring fibril formation R-HSA-2214320 6.126878e-01 0.213 0 0
Host Interactions of HIV factors R-HSA-162909 2.771485e-01 0.557 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.826207e-01 0.549 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.911388e-01 0.536 0 0
FLT3 Signaling R-HSA-9607240 4.929500e-01 0.307 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.516987e-01 0.599 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 2.911388e-01 0.536 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.194421e-01 0.208 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.915313e-01 0.407 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.916472e-01 0.407 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.849189e-01 0.233 0 0
tRNA processing R-HSA-72306 4.543308e-01 0.343 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.856075e-01 0.232 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.194421e-01 0.208 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.194421e-01 0.208 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.239882e-01 0.205 0 0
Signaling by Leptin R-HSA-2586552 5.354196e-01 0.271 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.458004e-01 0.190 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.474699e-01 0.189 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.474699e-01 0.189 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.474699e-01 0.189 0 0
Polymerase switching R-HSA-69091 6.474699e-01 0.189 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.474699e-01 0.189 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.474699e-01 0.189 0 0
Leading Strand Synthesis R-HSA-69109 6.474699e-01 0.189 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.474699e-01 0.189 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.474699e-01 0.189 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.474699e-01 0.189 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.474699e-01 0.189 0 0
Disorders of Nervous System Development R-HSA-9697154 6.474699e-01 0.189 0 0
Pervasive developmental disorders R-HSA-9005895 6.474699e-01 0.189 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.474699e-01 0.189 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.491604e-01 0.188 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.491604e-01 0.188 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.562815e-01 0.183 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.562815e-01 0.183 0 0
Signaling by FGFR1 R-HSA-5654736 6.564036e-01 0.183 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.564036e-01 0.183 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.583996e-01 0.182 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.590192e-01 0.181 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.635378e-01 0.178 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.667992e-01 0.176 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.667992e-01 0.176 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.669240e-01 0.176 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.669240e-01 0.176 0 0
Cellular responses to stimuli R-HSA-8953897 6.671163e-01 0.176 0 0
MAP2K and MAPK activation R-HSA-5674135 6.681463e-01 0.175 0 0
PKR-mediated signaling R-HSA-9833482 6.681651e-01 0.175 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.685134e-01 0.175 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.685134e-01 0.175 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.685134e-01 0.175 0 0
PDE3B signalling R-HSA-165160 6.685134e-01 0.175 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.685134e-01 0.175 0 0
PKB-mediated events R-HSA-109703 6.685134e-01 0.175 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.685134e-01 0.175 0 0
Signaling by MAPK mutants R-HSA-9652817 6.685134e-01 0.175 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.685134e-01 0.175 0 0
Ligand-receptor interactions R-HSA-5632681 6.685134e-01 0.175 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.685134e-01 0.175 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.685134e-01 0.175 0 0
Synthesis of PS R-HSA-1483101 6.685134e-01 0.175 0 0
Sensory perception of salty taste R-HSA-9730628 6.685134e-01 0.175 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.685134e-01 0.175 0 0
Relaxin receptors R-HSA-444821 6.685134e-01 0.175 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.685134e-01 0.175 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.699557e-01 0.174 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.699557e-01 0.174 0 0
Nephrin family interactions R-HSA-373753 6.699557e-01 0.174 0 0
PPARA activates gene expression R-HSA-1989781 6.779772e-01 0.169 0 0
Ca2+ pathway R-HSA-4086398 6.789537e-01 0.168 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 6.797247e-01 0.168 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.797247e-01 0.168 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.797247e-01 0.168 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.797247e-01 0.168 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.797247e-01 0.168 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.797247e-01 0.168 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.841428e-01 0.165 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.869570e-01 0.163 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.869657e-01 0.163 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.869657e-01 0.163 0 0
Signaling by WNT R-HSA-195721 6.904800e-01 0.161 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.905165e-01 0.161 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.905165e-01 0.161 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.952896e-01 0.158 0 0
Signalling to RAS R-HSA-167044 6.952896e-01 0.158 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.977059e-01 0.156 0 0
Influenza Infection R-HSA-168255 6.987272e-01 0.156 0 0
MHC class II antigen presentation R-HSA-2132295 7.014824e-01 0.154 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.044817e-01 0.152 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.045359e-01 0.152 0 0
GPVI-mediated activation cascade R-HSA-114604 7.062876e-01 0.151 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.062876e-01 0.151 0 0
Removal of the Flap Intermediate R-HSA-69166 7.095257e-01 0.149 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.095257e-01 0.149 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.095257e-01 0.149 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.095257e-01 0.149 0 0
Late endosomal microautophagy R-HSA-9615710 7.105240e-01 0.148 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.105240e-01 0.148 0 0
DARPP-32 events R-HSA-180024 7.105240e-01 0.148 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.112597e-01 0.148 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.112597e-01 0.148 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.112597e-01 0.148 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.112597e-01 0.148 0 0
MET Receptor Activation R-HSA-6806942 7.112597e-01 0.148 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.112597e-01 0.148 0 0
CREB phosphorylation R-HSA-199920 7.112597e-01 0.148 0 0
Signaling by LTK in cancer R-HSA-9842640 7.112597e-01 0.148 0 0
NADPH regeneration R-HSA-389542 7.112597e-01 0.148 0 0
CREB3 factors activate genes R-HSA-8874211 7.112597e-01 0.148 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.155101e-01 0.145 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.191228e-01 0.143 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.191228e-01 0.143 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.191228e-01 0.143 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.215457e-01 0.142 0 0
DAP12 interactions R-HSA-2172127 7.215457e-01 0.142 0 0
Interleukin-1 family signaling R-HSA-446652 7.232700e-01 0.141 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.247591e-01 0.140 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.247591e-01 0.140 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.306984e-01 0.136 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.340757e-01 0.134 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.340757e-01 0.134 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.340757e-01 0.134 0 0
IRE1alpha activates chaperones R-HSA-381070 7.353705e-01 0.133 0 0
Translesion synthesis by REV1 R-HSA-110312 7.369692e-01 0.133 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.369692e-01 0.133 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.369692e-01 0.133 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.369692e-01 0.133 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.369692e-01 0.133 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.369692e-01 0.133 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.369692e-01 0.133 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 7.369692e-01 0.133 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.369692e-01 0.133 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.379483e-01 0.132 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.379483e-01 0.132 0 0
Developmental Biology R-HSA-1266738 7.410989e-01 0.130 0 0
FGFR2 alternative splicing R-HSA-6803529 7.414801e-01 0.130 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.414801e-01 0.130 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.414801e-01 0.130 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.423804e-01 0.129 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.465497e-01 0.127 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.480644e-01 0.126 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.484958e-01 0.126 0 0
Glycoprotein hormones R-HSA-209822 7.484958e-01 0.126 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.484958e-01 0.126 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.484958e-01 0.126 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.484958e-01 0.126 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.484958e-01 0.126 0 0
Recycling of eIF2:GDP R-HSA-72731 7.484958e-01 0.126 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.484958e-01 0.126 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.484958e-01 0.126 0 0
PTK6 Expression R-HSA-8849473 7.484958e-01 0.126 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.484958e-01 0.126 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.484958e-01 0.126 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.484958e-01 0.126 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.484958e-01 0.126 0 0
VLDL clearance R-HSA-8964046 7.484958e-01 0.126 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.484958e-01 0.126 0 0
CHL1 interactions R-HSA-447041 7.484958e-01 0.126 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.501719e-01 0.125 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.536493e-01 0.123 0 0
Sensory processing of sound R-HSA-9659379 7.587410e-01 0.120 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.591564e-01 0.120 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.597515e-01 0.119 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.597515e-01 0.119 0 0
Chromosome Maintenance R-HSA-73886 7.611476e-01 0.119 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.621675e-01 0.118 0 0
Translesion synthesis by POLI R-HSA-5656121 7.621675e-01 0.118 0 0
Negative regulation of FLT3 R-HSA-9706369 7.621675e-01 0.118 0 0
Growth hormone receptor signaling R-HSA-982772 7.623973e-01 0.118 0 0
DNA strand elongation R-HSA-69190 7.678422e-01 0.115 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.678422e-01 0.115 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.678422e-01 0.115 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.686524e-01 0.114 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.686524e-01 0.114 0 0
Signaling by FGFR2 R-HSA-5654738 7.705888e-01 0.113 0 0
Insulin receptor signalling cascade R-HSA-74751 7.744749e-01 0.111 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.750966e-01 0.111 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.779457e-01 0.109 0 0
Selective autophagy R-HSA-9663891 7.806847e-01 0.108 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.809319e-01 0.107 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.809319e-01 0.107 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.809319e-01 0.107 0 0
Activation of RAS in B cells R-HSA-1169092 7.809319e-01 0.107 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.809319e-01 0.107 0 0
Adrenoceptors R-HSA-390696 7.809319e-01 0.107 0 0
Regulation by c-FLIP R-HSA-3371378 7.809319e-01 0.107 0 0
Formation of annular gap junctions R-HSA-196025 7.809319e-01 0.107 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.809319e-01 0.107 0 0
Co-stimulation by ICOS R-HSA-9927354 7.809319e-01 0.107 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.809319e-01 0.107 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.809319e-01 0.107 0 0
Dimerization of procaspase-8 R-HSA-69416 7.809319e-01 0.107 0 0
Alpha-defensins R-HSA-1462054 7.809319e-01 0.107 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.809319e-01 0.107 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.809319e-01 0.107 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.819187e-01 0.107 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.819187e-01 0.107 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.819187e-01 0.107 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.848499e-01 0.105 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.852433e-01 0.105 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.852433e-01 0.105 0 0
Translesion synthesis by POLK R-HSA-5655862 7.852433e-01 0.105 0 0
Glycine degradation R-HSA-6783984 7.852433e-01 0.105 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.852433e-01 0.105 0 0
Fibronectin matrix formation R-HSA-1566977 7.852433e-01 0.105 0 0
tRNA modification in the mitochondrion R-HSA-6787450 7.852433e-01 0.105 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.852433e-01 0.105 0 0
SLC transporter disorders R-HSA-5619102 7.854005e-01 0.105 0 0
Cellular response to hypoxia R-HSA-1234174 7.869009e-01 0.104 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.902147e-01 0.102 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.902147e-01 0.102 0 0
IRS-mediated signalling R-HSA-112399 7.909457e-01 0.102 0 0
Signaling by FGFR in disease R-HSA-1226099 7.954687e-01 0.099 0 0
DNA Replication R-HSA-69306 7.992178e-01 0.097 0 0
Laminin interactions R-HSA-3000157 8.000955e-01 0.097 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.008491e-01 0.096 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.036384e-01 0.095 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.063249e-01 0.093 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.063249e-01 0.093 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.063249e-01 0.093 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.063249e-01 0.093 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.063249e-01 0.093 0 0
RSV-host interactions R-HSA-9833110 8.082610e-01 0.092 0 0
CASP8 activity is inhibited R-HSA-5218900 8.091863e-01 0.092 0 0
Gap junction degradation R-HSA-190873 8.091863e-01 0.092 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.091863e-01 0.092 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.091863e-01 0.092 0 0
mRNA Editing R-HSA-75072 8.091863e-01 0.092 0 0
ARMS-mediated activation R-HSA-170984 8.091863e-01 0.092 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.091863e-01 0.092 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 8.091863e-01 0.092 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 8.091863e-01 0.092 0 0
Lipophagy R-HSA-9613354 8.091863e-01 0.092 0 0
Interleukin-1 processing R-HSA-448706 8.091863e-01 0.092 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.091863e-01 0.092 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.091863e-01 0.092 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.091863e-01 0.092 0 0
PI3K Cascade R-HSA-109704 8.095551e-01 0.092 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.104237e-01 0.091 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.152096e-01 0.089 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.158705e-01 0.088 0 0
MET activates PTK2 signaling R-HSA-8874081 8.169839e-01 0.088 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.180546e-01 0.087 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.180546e-01 0.087 0 0
Depyrimidination R-HSA-73928 8.180546e-01 0.087 0 0
Regulated Necrosis R-HSA-5218859 8.211236e-01 0.086 0 0
Mismatch Repair R-HSA-5358508 8.255425e-01 0.083 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.255425e-01 0.083 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.255425e-01 0.083 0 0
HCMV Infection R-HSA-9609646 8.287888e-01 0.082 0 0
EPH-Ephrin signaling R-HSA-2682334 8.300531e-01 0.081 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.326432e-01 0.080 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.326432e-01 0.080 0 0
Packaging Of Telomere Ends R-HSA-171306 8.326432e-01 0.080 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.326432e-01 0.080 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.326432e-01 0.080 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.326432e-01 0.080 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.335261e-01 0.079 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.337981e-01 0.079 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.337981e-01 0.079 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.337981e-01 0.079 0 0
Peptide hormone biosynthesis R-HSA-209952 8.337981e-01 0.079 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.337981e-01 0.079 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.337981e-01 0.079 0 0
2-LTR circle formation R-HSA-164843 8.337981e-01 0.079 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.337981e-01 0.079 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.337981e-01 0.079 0 0
Synthesis of DNA R-HSA-69239 8.342054e-01 0.079 0 0
Collagen degradation R-HSA-1442490 8.372286e-01 0.077 0 0
Aquaporin-mediated transport R-HSA-445717 8.372286e-01 0.077 0 0
PLC beta mediated events R-HSA-112043 8.372286e-01 0.077 0 0
COPII-mediated vesicle transport R-HSA-204005 8.414728e-01 0.075 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.422367e-01 0.075 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.430264e-01 0.074 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.430264e-01 0.074 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.430264e-01 0.074 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.430264e-01 0.074 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.430264e-01 0.074 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.430264e-01 0.074 0 0
Other interleukin signaling R-HSA-449836 8.430264e-01 0.074 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.430264e-01 0.074 0 0
Interleukin-1 signaling R-HSA-9020702 8.444843e-01 0.073 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.445700e-01 0.073 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.471355e-01 0.072 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.471355e-01 0.072 0 0
Pyroptosis R-HSA-5620971 8.471355e-01 0.072 0 0
Signaling by PDGF R-HSA-186797 8.474280e-01 0.072 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.508862e-01 0.070 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.541534e-01 0.068 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.541534e-01 0.068 0 0
Somitogenesis R-HSA-9824272 8.541534e-01 0.068 0 0
Translation initiation complex formation R-HSA-72649 8.550107e-01 0.068 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.550107e-01 0.068 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.552365e-01 0.068 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.552365e-01 0.068 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.552365e-01 0.068 0 0
vRNA Synthesis R-HSA-192814 8.552365e-01 0.068 0 0
Hormone ligand-binding receptors R-HSA-375281 8.552365e-01 0.068 0 0
Transport of RCbl within the body R-HSA-9758890 8.552365e-01 0.068 0 0
LGI-ADAM interactions R-HSA-5682910 8.552365e-01 0.068 0 0
PECAM1 interactions R-HSA-210990 8.552365e-01 0.068 0 0
Suppression of apoptosis R-HSA-9635465 8.552365e-01 0.068 0 0
Degradation of AXIN R-HSA-4641257 8.554175e-01 0.068 0 0
Cleavage of the damaged purine R-HSA-110331 8.554175e-01 0.068 0 0
Collagen chain trimerization R-HSA-8948216 8.554175e-01 0.068 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.589039e-01 0.066 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.589039e-01 0.066 0 0
Creatine metabolism R-HSA-71288 8.589039e-01 0.066 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.599449e-01 0.066 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.605236e-01 0.065 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.605236e-01 0.065 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.647773e-01 0.063 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.648681e-01 0.063 0 0
Depurination R-HSA-73927 8.668868e-01 0.062 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.668868e-01 0.062 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.685072e-01 0.061 0 0
Lagging Strand Synthesis R-HSA-69186 8.732985e-01 0.059 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.732985e-01 0.059 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.732985e-01 0.059 0 0
Basigin interactions R-HSA-210991 8.732985e-01 0.059 0 0
Autophagy R-HSA-9612973 8.734572e-01 0.059 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.739107e-01 0.059 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.739107e-01 0.059 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.739107e-01 0.059 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.739107e-01 0.059 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.739107e-01 0.059 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.739107e-01 0.059 0 0
DS-GAG biosynthesis R-HSA-2022923 8.739107e-01 0.059 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.741628e-01 0.058 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.741628e-01 0.058 0 0
Ion homeostasis R-HSA-5578775 8.741628e-01 0.058 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.747420e-01 0.058 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.749022e-01 0.058 0 0
Macroautophagy R-HSA-1632852 8.759992e-01 0.057 0 0
Signaling by NOTCH4 R-HSA-9013694 8.766376e-01 0.057 0 0
Stabilization of p53 R-HSA-69541 8.775653e-01 0.057 0 0
Budding and maturation of HIV virion R-HSA-162588 8.842397e-01 0.053 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.842397e-01 0.053 0 0
Signaling by FGFR R-HSA-190236 8.843132e-01 0.053 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.863284e-01 0.052 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.863284e-01 0.052 0 0
Assembly Of The HIV Virion R-HSA-175474 8.863284e-01 0.052 0 0
Aggrephagy R-HSA-9646399 8.874930e-01 0.052 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.901770e-01 0.051 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.901770e-01 0.051 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.901770e-01 0.051 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.901770e-01 0.051 0 0
OAS antiviral response R-HSA-8983711 8.901770e-01 0.051 0 0
G-protein mediated events R-HSA-112040 8.909284e-01 0.050 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.911492e-01 0.050 0 0
Degradation of CDH1 R-HSA-9766229 8.928071e-01 0.049 0 0
Co-inhibition by PD-1 R-HSA-389948 8.942255e-01 0.049 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.967099e-01 0.047 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.981061e-01 0.047 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.981061e-01 0.047 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.981061e-01 0.047 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.981061e-01 0.047 0 0
Signaling by KIT in disease R-HSA-9669938 8.981061e-01 0.047 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.009647e-01 0.045 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.042884e-01 0.044 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.043456e-01 0.044 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 9.043456e-01 0.044 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.043456e-01 0.044 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 9.043456e-01 0.044 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.043456e-01 0.044 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.043456e-01 0.044 0 0
Processing of SMDT1 R-HSA-8949664 9.043456e-01 0.044 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.043456e-01 0.044 0 0
Maturation of nucleoprotein R-HSA-9683610 9.043456e-01 0.044 0 0
Interleukin-6 signaling R-HSA-1059683 9.043456e-01 0.044 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.043456e-01 0.044 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.051409e-01 0.043 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.052553e-01 0.043 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.052553e-01 0.043 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.052553e-01 0.043 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.052553e-01 0.043 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.087378e-01 0.042 0 0
Carnitine shuttle R-HSA-200425 9.087378e-01 0.042 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.087378e-01 0.042 0 0
Syndecan interactions R-HSA-3000170 9.087378e-01 0.042 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.087378e-01 0.042 0 0
Formation of the ureteric bud R-HSA-9830674 9.087378e-01 0.042 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.116511e-01 0.040 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.130865e-01 0.039 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.130865e-01 0.039 0 0
Orc1 removal from chromatin R-HSA-68949 9.156717e-01 0.038 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 9.166869e-01 0.038 0 0
NRIF signals cell death from the nucleus R-HSA-205043 9.166869e-01 0.038 0 0
Physiological factors R-HSA-5578768 9.166869e-01 0.038 1 1
Non-canonical inflammasome activation R-HSA-9686114 9.166869e-01 0.038 0 0
HDL assembly R-HSA-8963896 9.166869e-01 0.038 0 0
P2Y receptors R-HSA-417957 9.166869e-01 0.038 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.166869e-01 0.038 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.183231e-01 0.037 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.183231e-01 0.037 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.211249e-01 0.036 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.211423e-01 0.036 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.211423e-01 0.036 0 0
Mitophagy R-HSA-5205647 9.211423e-01 0.036 0 0
Signaling by NOTCH2 R-HSA-1980145 9.211423e-01 0.036 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.222769e-01 0.035 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.234773e-01 0.035 0 0
Toll-like Receptor Cascades R-HSA-168898 9.240646e-01 0.034 0 0
Potential therapeutics for SARS R-HSA-9679191 9.243087e-01 0.034 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.252784e-01 0.034 0 0
Vesicle-mediated transport R-HSA-5653656 9.258974e-01 0.033 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.269550e-01 0.033 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.269550e-01 0.033 0 0
Tight junction interactions R-HSA-420029 9.269550e-01 0.033 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.269550e-01 0.033 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.269550e-01 0.033 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.272456e-01 0.033 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 9.274367e-01 0.033 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 9.274367e-01 0.033 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 9.274367e-01 0.033 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.274367e-01 0.033 0 0
Protein lipoylation R-HSA-9857492 9.274367e-01 0.033 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.274367e-01 0.033 0 0
DNA Damage Reversal R-HSA-73942 9.274367e-01 0.033 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 9.274367e-01 0.033 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.274367e-01 0.033 0 0
p38MAPK events R-HSA-171007 9.274367e-01 0.033 0 0
Protein methylation R-HSA-8876725 9.274367e-01 0.033 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.285095e-01 0.032 0 0
Signaling by ERBB4 R-HSA-1236394 9.339147e-01 0.030 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.347198e-01 0.029 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.347198e-01 0.029 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.347198e-01 0.029 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.347198e-01 0.029 0 0
Triglyceride catabolism R-HSA-163560 9.352391e-01 0.029 0 0
Signaling by ROBO receptors R-HSA-376176 9.359344e-01 0.029 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.367999e-01 0.028 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.367999e-01 0.028 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.367999e-01 0.028 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 9.367999e-01 0.028 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.367999e-01 0.028 0 0
Killing mechanisms R-HSA-9664420 9.367999e-01 0.028 0 0
Mineralocorticoid biosynthesis R-HSA-193993 9.367999e-01 0.028 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.386478e-01 0.027 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.386478e-01 0.027 0 0
Signaling by Insulin receptor R-HSA-74752 9.407478e-01 0.027 0 0
Protein folding R-HSA-391251 9.407478e-01 0.027 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.408953e-01 0.026 0 0
NCAM1 interactions R-HSA-419037 9.413794e-01 0.026 0 0
Cristae formation R-HSA-8949613 9.416976e-01 0.026 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.416976e-01 0.026 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.428783e-01 0.026 0 0
Regulation of CDH1 Function R-HSA-9764561 9.443303e-01 0.025 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.449554e-01 0.025 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.449554e-01 0.025 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.449554e-01 0.025 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.449554e-01 0.025 0 0
Coenzyme A biosynthesis R-HSA-196783 9.449554e-01 0.025 0 0
Passive transport by Aquaporins R-HSA-432047 9.449554e-01 0.025 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.449554e-01 0.025 0 0
Synthesis of PG R-HSA-1483148 9.449554e-01 0.025 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.469759e-01 0.024 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.479621e-01 0.023 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.479621e-01 0.023 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.479621e-01 0.023 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.479621e-01 0.023 0 0
Dual incision in TC-NER R-HSA-6782135 9.488772e-01 0.023 0 0
Co-stimulation by CD28 R-HSA-389356 9.493911e-01 0.023 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.515924e-01 0.022 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.520590e-01 0.021 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.520590e-01 0.021 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.520590e-01 0.021 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.520590e-01 0.021 0 0
Glycogen storage diseases R-HSA-3229121 9.520590e-01 0.021 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.520590e-01 0.021 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.520718e-01 0.021 0 0
Interferon gamma signaling R-HSA-877300 9.532450e-01 0.021 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.535812e-01 0.021 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.535812e-01 0.021 0 0
Platelet calcium homeostasis R-HSA-418360 9.535812e-01 0.021 0 0
Glucagon-type ligand receptors R-HSA-420092 9.535812e-01 0.021 0 0
DNA Damage Bypass R-HSA-73893 9.538638e-01 0.021 0 0
Opioid Signalling R-HSA-111885 9.543700e-01 0.020 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.567072e-01 0.019 0 0
Attenuation phase R-HSA-3371568 9.567072e-01 0.019 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.567072e-01 0.019 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.567072e-01 0.019 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.571660e-01 0.019 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.582036e-01 0.019 0 0
GAB1 signalosome R-HSA-180292 9.582461e-01 0.019 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.582461e-01 0.019 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.582461e-01 0.019 0 0
Platelet sensitization by LDL R-HSA-432142 9.582461e-01 0.019 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.582461e-01 0.019 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.582461e-01 0.019 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.609198e-01 0.017 0 0
Telomere Maintenance R-HSA-157579 9.610859e-01 0.017 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.617351e-01 0.017 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.617351e-01 0.017 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.617629e-01 0.017 0 0
Base Excision Repair R-HSA-73884 9.623743e-01 0.017 0 0
Cargo concentration in the ER R-HSA-5694530 9.631267e-01 0.016 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.634114e-01 0.016 0 0
Translesion Synthesis by POLH R-HSA-110320 9.636351e-01 0.016 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.636351e-01 0.016 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.636351e-01 0.016 0 0
Diseases of hemostasis R-HSA-9671793 9.636351e-01 0.016 0 0
Maturation of nucleoprotein R-HSA-9694631 9.636351e-01 0.016 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.636351e-01 0.016 0 0
The NLRP3 inflammasome R-HSA-844456 9.636351e-01 0.016 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.636351e-01 0.016 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.638816e-01 0.016 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.647447e-01 0.016 0 0
Intra-Golgi traffic R-HSA-6811438 9.647447e-01 0.016 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.651856e-01 0.015 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.662794e-01 0.015 0 0
Signaling by Interleukins R-HSA-449147 9.671135e-01 0.015 0 0
Stimuli-sensing channels R-HSA-2672351 9.677090e-01 0.014 0 0
GABA B receptor activation R-HSA-977444 9.682147e-01 0.014 0 0
Activation of GABAB receptors R-HSA-991365 9.682147e-01 0.014 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.682147e-01 0.014 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.683288e-01 0.014 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.683288e-01 0.014 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.683288e-01 0.014 0 0
Glycogen synthesis R-HSA-3322077 9.683288e-01 0.014 0 0
Pregnenolone biosynthesis R-HSA-196108 9.683288e-01 0.014 0 0
Signal transduction by L1 R-HSA-445144 9.683288e-01 0.014 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.683446e-01 0.014 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.683446e-01 0.014 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.696207e-01 0.013 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.697550e-01 0.013 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.705987e-01 0.013 0 0
Recycling of bile acids and salts R-HSA-159418 9.707701e-01 0.013 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.712344e-01 0.013 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.717532e-01 0.012 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.717884e-01 0.012 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.723479e-01 0.012 0 0
G alpha (z) signalling events R-HSA-418597 9.738758e-01 0.011 0 0
Striated Muscle Contraction R-HSA-390522 9.739942e-01 0.011 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.739942e-01 0.011 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.743149e-01 0.011 0 0
Neddylation R-HSA-8951664 9.753006e-01 0.011 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.757303e-01 0.011 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.757303e-01 0.011 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.759776e-01 0.011 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.759776e-01 0.011 0 0
Glutathione synthesis and recycling R-HSA-174403 9.759776e-01 0.011 0 0
Androgen biosynthesis R-HSA-193048 9.759776e-01 0.011 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.762883e-01 0.010 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.767421e-01 0.010 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.767872e-01 0.010 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.767872e-01 0.010 0 0
Dual Incision in GG-NER R-HSA-5696400 9.768733e-01 0.010 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.768733e-01 0.010 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.768733e-01 0.010 0 0
SARS-CoV Infections R-HSA-9679506 9.769511e-01 0.010 0 0
Integration of energy metabolism R-HSA-163685 9.772030e-01 0.010 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.790788e-01 0.009 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.790788e-01 0.009 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 9.790788e-01 0.009 0 0
Ethanol oxidation R-HSA-71384 9.790788e-01 0.009 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.790788e-01 0.009 0 0
LDL clearance R-HSA-8964038 9.790788e-01 0.009 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.790788e-01 0.009 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.791190e-01 0.009 0 0
PERK regulates gene expression R-HSA-381042 9.794426e-01 0.009 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.794426e-01 0.009 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.811243e-01 0.008 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.817341e-01 0.008 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.817341e-01 0.008 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.817341e-01 0.008 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.817798e-01 0.008 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.817798e-01 0.008 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.817798e-01 0.008 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.817798e-01 0.008 0 0
Extension of Telomeres R-HSA-180786 9.823280e-01 0.008 0 0
Triglyceride metabolism R-HSA-8979227 9.823280e-01 0.008 0 0
Regulation of beta-cell development R-HSA-186712 9.823280e-01 0.008 0 0
Neurotransmitter release cycle R-HSA-112310 9.827656e-01 0.008 0 0
Amyloid fiber formation R-HSA-977225 9.831745e-01 0.007 0 0
Interferon alpha/beta signaling R-HSA-909733 9.831938e-01 0.007 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.837768e-01 0.007 0 0
Voltage gated Potassium channels R-HSA-1296072 9.837768e-01 0.007 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.837768e-01 0.007 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.839945e-01 0.007 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.841322e-01 0.007 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.841322e-01 0.007 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.841322e-01 0.007 0 0
Complex III assembly R-HSA-9865881 9.841322e-01 0.007 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.841322e-01 0.007 0 0
Interleukin-6 family signaling R-HSA-6783589 9.841322e-01 0.007 0 0
Biofilm formation R-HSA-9931953 9.855967e-01 0.006 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.859014e-01 0.006 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.861810e-01 0.006 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.861810e-01 0.006 0 0
G protein gated Potassium channels R-HSA-1296059 9.861810e-01 0.006 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.861810e-01 0.006 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.861810e-01 0.006 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.861810e-01 0.006 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.861810e-01 0.006 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.863897e-01 0.006 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.863962e-01 0.006 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.864170e-01 0.006 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.868907e-01 0.006 0 0
Mitochondrial protein import R-HSA-1268020 9.868907e-01 0.006 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.872172e-01 0.006 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.879654e-01 0.005 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.879654e-01 0.005 0 0
Urea cycle R-HSA-70635 9.879654e-01 0.005 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.881222e-01 0.005 0 0
Generation of second messenger molecules R-HSA-202433 9.886595e-01 0.005 0 0
Diseases of Immune System R-HSA-5260271 9.886595e-01 0.005 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.886595e-01 0.005 0 0
Collagen formation R-HSA-1474290 9.887243e-01 0.005 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.890507e-01 0.005 0 0
Ion transport by P-type ATPases R-HSA-936837 9.892836e-01 0.005 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.893426e-01 0.005 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.895194e-01 0.005 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.895194e-01 0.005 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.895194e-01 0.005 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.895194e-01 0.005 0 0
Triglyceride biosynthesis R-HSA-75109 9.895194e-01 0.005 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.895194e-01 0.005 0 0
Insulin processing R-HSA-264876 9.895194e-01 0.005 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.899425e-01 0.004 0 0
Maturation of spike protein R-HSA-9694548 9.899425e-01 0.004 0 0
Interleukin-12 signaling R-HSA-9020591 9.900422e-01 0.004 0 0
Smooth Muscle Contraction R-HSA-445355 9.901834e-01 0.004 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.904708e-01 0.004 0 0
Telomere Extension By Telomerase R-HSA-171319 9.908729e-01 0.004 0 0
Insulin receptor recycling R-HSA-77387 9.908729e-01 0.004 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.908729e-01 0.004 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.908729e-01 0.004 0 0
Pyrimidine salvage R-HSA-73614 9.908729e-01 0.004 0 0
Inflammasomes R-HSA-622312 9.908729e-01 0.004 0 0
Cellular response to starvation R-HSA-9711097 9.909915e-01 0.004 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.910834e-01 0.004 0 0
Heme biosynthesis R-HSA-189451 9.910834e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.910834e-01 0.004 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.910924e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.911256e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.911256e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.911256e-01 0.004 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.913062e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.915607e-01 0.004 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.917572e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.920517e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.920517e-01 0.003 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.920517e-01 0.003 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.920517e-01 0.003 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.921192e-01 0.003 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.925070e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.928776e-01 0.003 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.929984e-01 0.003 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.929984e-01 0.003 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.930233e-01 0.003 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.930233e-01 0.003 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.930782e-01 0.003 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.930782e-01 0.003 0 0
Neurotransmitter clearance R-HSA-112311 9.930782e-01 0.003 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.930782e-01 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.931783e-01 0.003 0 0
Proteasome assembly R-HSA-9907900 9.937985e-01 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.937985e-01 0.003 0 0
Amine ligand-binding receptors R-HSA-375280 9.937985e-01 0.003 0 0
Surfactant metabolism R-HSA-5683826 9.937985e-01 0.003 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.939723e-01 0.003 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.939723e-01 0.003 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.939723e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.939723e-01 0.003 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.945088e-01 0.002 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.947509e-01 0.002 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.947509e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.949450e-01 0.002 0 0
Cellular response to chemical stress R-HSA-9711123 9.952860e-01 0.002 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.952980e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.953037e-01 0.002 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.954289e-01 0.002 0 0
G-protein beta:gamma signalling R-HSA-397795 9.954289e-01 0.002 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.954289e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.954803e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.954803e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.954803e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.956982e-01 0.002 0 0
Endogenous sterols R-HSA-211976 9.959603e-01 0.002 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.960194e-01 0.002 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.960194e-01 0.002 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.961127e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.961885e-01 0.002 0 0
Metal ion SLC transporters R-HSA-425410 9.961940e-01 0.002 0 0
eNOS activation R-HSA-203615 9.965337e-01 0.002 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.965337e-01 0.002 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.965337e-01 0.002 0 0
Signal amplification R-HSA-392518 9.965337e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.965337e-01 0.002 0 0
Hyaluronan metabolism R-HSA-2142845 9.965337e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.965337e-01 0.002 0 0
Gap junction trafficking and regulation R-HSA-157858 9.966336e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.966336e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.967762e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.968033e-01 0.001 0 0
Interleukin-12 family signaling R-HSA-447115 9.969319e-01 0.001 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.969816e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.969816e-01 0.001 0 0
Regulation of Apoptosis R-HSA-169911 9.969816e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.969816e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.969816e-01 0.001 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.970743e-01 0.001 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.970743e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.973486e-01 0.001 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.973682e-01 0.001 0 0
HSF1 activation R-HSA-3371511 9.973716e-01 0.001 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.973716e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.973716e-01 0.001 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.973843e-01 0.001 0 0
Adaptive Immune System R-HSA-1280218 9.973902e-01 0.001 0 0
Platelet degranulation R-HSA-114608 9.973961e-01 0.001 0 0
PCP/CE pathway R-HSA-4086400 9.975065e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.975065e-01 0.001 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.976739e-01 0.001 0 0
Degradation of DVL R-HSA-4641258 9.977112e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.977112e-01 0.001 0 0
Downstream TCR signaling R-HSA-202424 9.977339e-01 0.001 0 0
TCR signaling R-HSA-202403 9.977578e-01 0.001 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.979450e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.979548e-01 0.001 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.980070e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.980070e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.981402e-01 0.001 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.981516e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.982645e-01 0.001 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.982645e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.982645e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.982645e-01 0.001 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.983584e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.984577e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.984834e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.984888e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.984888e-01 0.001 0 0
Glycogen metabolism R-HSA-8982491 9.984888e-01 0.001 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.984888e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.985507e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.985861e-01 0.001 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.985882e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.986841e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.987087e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.987087e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.987494e-01 0.001 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.988542e-01 0.000 0 0
Translation of Structural Proteins R-HSA-9683701 9.988542e-01 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.988961e-01 0.000 0 0
Platelet homeostasis R-HSA-418346 9.989017e-01 0.000 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.989497e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.990023e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.990048e-01 0.000 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.990190e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.990257e-01 0.000 0 0
Defensins R-HSA-1461973 9.991313e-01 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 9.991347e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.991843e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.991882e-01 0.000 0 0
Protein ubiquitination R-HSA-8852135 9.991882e-01 0.000 0 0
Gap junction trafficking R-HSA-190828 9.992436e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.992436e-01 0.000 0 0
Peptide chain elongation R-HSA-156902 9.992443e-01 0.000 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.993414e-01 0.000 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.993414e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.993414e-01 0.000 0 0
Translation of Structural Proteins R-HSA-9694635 9.993573e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.993959e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.994265e-01 0.000 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.994265e-01 0.000 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.994265e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.994265e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.994284e-01 0.000 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.994576e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.994917e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.995007e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.995515e-01 0.000 0 0
Intraflagellar transport R-HSA-5620924 9.995652e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.995652e-01 0.000 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.995658e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.996215e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.996215e-01 0.000 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.996222e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.996437e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.996437e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.996437e-01 0.000 0 0
Kidney development R-HSA-9830369 9.996437e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.996704e-01 0.000 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.996861e-01 0.000 0 0
Neuronal System R-HSA-112316 9.996997e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.997130e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.997130e-01 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.997205e-01 0.000 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.997225e-01 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 9.997225e-01 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 9.997325e-01 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.997441e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997854e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997854e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.998017e-01 0.000 1 0
Protein localization R-HSA-9609507 9.998126e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998336e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.998351e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998564e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.998593e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998710e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.998750e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.998880e-01 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 9.999119e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.999121e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999121e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.999121e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.999148e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.999148e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999175e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999175e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999282e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.999330e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.999330e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.999341e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.999437e-01 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.999475e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999526e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999535e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.999714e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999728e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999752e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999786e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999789e-01 0.000 0 0
rRNA processing R-HSA-72312 9.999807e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999820e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999820e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999844e-01 0.000 0 0
Muscle contraction R-HSA-397014 9.999848e-01 0.000 1 0
Mitochondrial protein degradation R-HSA-9837999 9.999914e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999941e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999955e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999960e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999970e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999973e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999976e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999977e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999980e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999983e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.999987e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999989e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999991e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999992e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999993e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999993e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999993e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999995e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999995e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999996e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999996e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999996e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999996e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999996e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999997e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999997e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999997e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999999e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999999e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Immune System R-HSA-168256 9.999999e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
G alpha (q) signalling events R-HSA-416476 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Neutrophil degranulation R-HSA-6798695 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.274987e-10 9.894 0 0
Cell Cycle R-HSA-1640170 1.932967e-10 9.714 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.715376e-09 8.766 0 0
Cell Cycle, Mitotic R-HSA-69278 3.999284e-08 7.398 0 0
HSF1-dependent transactivation R-HSA-3371571 8.079217e-08 7.093 0 0
Attenuation phase R-HSA-3371568 1.824171e-07 6.739 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.952293e-07 6.709 0 0
Signaling by ALK in cancer R-HSA-9700206 1.952293e-07 6.709 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.682250e-07 6.434 0 0
Activation of BH3-only proteins R-HSA-114452 4.917544e-07 6.308 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.089065e-07 6.092 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.467402e-06 5.460 0 0
Cell Cycle Checkpoints R-HSA-69620 6.509444e-06 5.186 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.056414e-05 4.976 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.276234e-05 4.894 0 0
M Phase R-HSA-68886 1.192751e-05 4.923 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.368470e-05 4.864 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.620822e-05 4.790 0 0
HSF1 activation R-HSA-3371511 1.905061e-05 4.720 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.833547e-05 4.737 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.626421e-05 4.581 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.440160e-05 4.463 0 0
Cellular responses to stress R-HSA-2262752 3.412434e-05 4.467 0 0
Nuclear import of Rev protein R-HSA-180746 4.466949e-05 4.350 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.739880e-05 4.324 0 0
Signaling by Hippo R-HSA-2028269 5.479041e-05 4.261 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.222141e-05 4.206 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.222141e-05 4.206 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.980824e-05 4.223 0 0
Gene expression (Transcription) R-HSA-74160 6.236495e-05 4.205 1 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.394080e-05 4.194 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.104902e-05 4.148 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.091123e-05 4.092 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 9.449443e-05 4.025 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.319393e-05 4.031 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.391352e-05 4.027 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.042771e-04 3.982 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.332534e-04 3.875 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.526997e-04 3.816 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.822284e-04 3.739 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.822284e-04 3.739 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.124746e-04 3.673 0 0
Mitotic Prophase R-HSA-68875 2.218951e-04 3.654 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.321606e-04 3.634 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.371709e-04 3.625 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.872631e-04 3.542 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.872631e-04 3.542 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.990314e-04 3.524 1 0
Mitotic Prometaphase R-HSA-68877 2.928295e-04 3.533 0 0
Mitotic Anaphase R-HSA-68882 3.033688e-04 3.518 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.047717e-04 3.516 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.331596e-04 3.477 0 0
Chromatin organization R-HSA-4839726 3.280376e-04 3.484 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.291931e-04 3.483 0 0
MTOR signalling R-HSA-165159 3.366755e-04 3.473 0 0
Membrane Trafficking R-HSA-199991 4.117185e-04 3.385 0 0
tRNA processing in the nucleus R-HSA-6784531 4.206856e-04 3.376 0 0
Cellular responses to stimuli R-HSA-8953897 3.889770e-04 3.410 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.052817e-04 3.392 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.530860e-04 3.344 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.960633e-04 3.304 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.313552e-04 3.275 0 0
Apoptosis R-HSA-109581 5.358612e-04 3.271 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.549607e-04 3.256 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.027409e-04 3.220 0 0
Metabolism of non-coding RNA R-HSA-194441 7.287140e-04 3.137 0 0
snRNP Assembly R-HSA-191859 7.287140e-04 3.137 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.068021e-04 3.151 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.299232e-04 3.137 0 0
RNA Polymerase II Transcription R-HSA-73857 7.440903e-04 3.128 1 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.748293e-04 3.058 0 0
Regulation of PTEN gene transcription R-HSA-8943724 8.488408e-04 3.071 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.321102e-04 3.031 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.021156e-03 2.991 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.032535e-03 2.986 0 0
ALK mutants bind TKIs R-HSA-9700645 1.032535e-03 2.986 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.043565e-03 2.981 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.078096e-03 2.967 0 0
Chromatin modifying enzymes R-HSA-3247509 1.191477e-03 2.924 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.235584e-03 2.908 0 0
Separation of Sister Chromatids R-HSA-2467813 1.261319e-03 2.899 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.479601e-03 2.830 0 0
mTORC1-mediated signalling R-HSA-166208 1.480397e-03 2.830 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.480397e-03 2.830 0 0
Programmed Cell Death R-HSA-5357801 1.568325e-03 2.805 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.745073e-03 2.758 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.872430e-03 2.728 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.048986e-03 2.688 0 0
Apoptotic execution phase R-HSA-75153 2.047587e-03 2.689 0 0
S Phase R-HSA-69242 2.405077e-03 2.619 0 0
Generic Transcription Pathway R-HSA-212436 2.416490e-03 2.617 1 0
SARS-CoV-2-host interactions R-HSA-9705683 2.457874e-03 2.609 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.557930e-03 2.592 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.679015e-03 2.572 0 0
NGF-stimulated transcription R-HSA-9031628 2.782544e-03 2.556 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.816123e-03 2.550 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.599699e-03 2.444 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.703513e-03 2.431 0 0
Formation of annular gap junctions R-HSA-196025 4.001577e-03 2.398 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.172233e-03 2.380 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.172233e-03 2.380 0 0
Cellular Senescence R-HSA-2559583 4.621604e-03 2.335 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.672072e-03 2.330 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.978547e-03 2.303 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.302645e-03 2.276 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.735253e-03 2.241 0 0
Gap junction degradation R-HSA-190873 5.735253e-03 2.241 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.735253e-03 2.241 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.491684e-03 2.188 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.491684e-03 2.188 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 6.491684e-03 2.188 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.491684e-03 2.188 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.491684e-03 2.188 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.491684e-03 2.188 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.491684e-03 2.188 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.491684e-03 2.188 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.491684e-03 2.188 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.491684e-03 2.188 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.491684e-03 2.188 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.491684e-03 2.188 0 0
Regulation of TP53 Activity R-HSA-5633007 6.047105e-03 2.218 1 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.511326e-03 2.186 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.461603e-03 2.127 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.103208e-03 2.149 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.589429e-03 2.120 0 0
Inositol phosphate metabolism R-HSA-1483249 7.467114e-03 2.127 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.940153e-03 2.100 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.717094e-03 2.060 0 0
G2/M Checkpoints R-HSA-69481 8.727705e-03 2.059 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.394868e-03 2.027 0 0
Signal Transduction R-HSA-162582 9.424215e-03 2.026 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.480587e-03 2.023 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.480587e-03 2.023 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.152404e-02 1.938 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.206412e-02 1.919 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.293788e-02 1.888 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.234356e-02 1.909 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.334184e-02 1.875 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.399000e-02 1.854 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.445502e-02 1.840 0 0
Signaling by NTRKs R-HSA-166520 1.477539e-02 1.830 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.493993e-02 1.826 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.493993e-02 1.826 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.527661e-02 1.816 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.527661e-02 1.816 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.527661e-02 1.816 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.527661e-02 1.816 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.527661e-02 1.816 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.527661e-02 1.816 0 0
Axon guidance R-HSA-422475 1.563920e-02 1.806 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.608449e-02 1.794 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.793272e-02 1.746 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.690102e-02 1.772 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.710562e-02 1.767 0 0
NRAGE signals death through JNK R-HSA-193648 1.876573e-02 1.727 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.909496e-02 1.719 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.912646e-02 1.718 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.912646e-02 1.718 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.999013e-02 1.699 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.036226e-02 1.691 0 0
Nervous system development R-HSA-9675108 2.072656e-02 1.683 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.112908e-02 1.675 0 0
Activation of the pre-replicative complex R-HSA-68962 2.113814e-02 1.675 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.113814e-02 1.675 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.254858e-02 1.647 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.254858e-02 1.647 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.254858e-02 1.647 0 0
Deadenylation of mRNA R-HSA-429947 2.384236e-02 1.623 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.284616e-02 1.641 0 0
Vesicle-mediated transport R-HSA-5653656 2.333460e-02 1.632 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.254858e-02 1.647 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.199253e-02 1.658 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.191003e-02 1.659 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.400500e-02 1.620 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.610311e-02 1.583 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.685365e-02 1.571 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.685365e-02 1.571 0 0
Unwinding of DNA R-HSA-176974 2.685365e-02 1.571 0 0
G2 Phase R-HSA-68911 2.839249e-02 1.547 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.839249e-02 1.547 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.776741e-02 1.556 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.776741e-02 1.556 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.057240e-02 1.515 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.843864e-02 1.546 0 0
G0 and Early G1 R-HSA-1538133 2.785462e-02 1.555 0 0
Signaling by ERBB2 R-HSA-1227986 2.806790e-02 1.552 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.839249e-02 1.547 0 0
MAP kinase activation R-HSA-450294 3.083981e-02 1.511 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.096285e-02 1.509 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.117521e-02 1.506 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.117521e-02 1.506 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.137675e-02 1.503 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.210883e-02 1.493 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.210883e-02 1.493 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.234852e-02 1.490 0 0
G alpha (12/13) signalling events R-HSA-416482 3.363541e-02 1.473 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.392991e-02 1.469 0 0
p75NTR signals via NF-kB R-HSA-193639 3.392991e-02 1.469 0 0
DCC mediated attractive signaling R-HSA-418885 3.392991e-02 1.469 0 0
Glycolysis R-HSA-70171 3.413865e-02 1.467 0 0
Josephin domain DUBs R-HSA-5689877 3.445030e-02 1.463 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.445030e-02 1.463 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.581509e-02 1.446 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.963345e-02 1.402 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.074547e-02 1.390 0 0
PTEN Regulation R-HSA-6807070 3.891916e-02 1.410 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.000994e-02 1.398 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.963345e-02 1.402 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.829777e-02 1.417 0 0
Signaling by PTK6 R-HSA-8848021 3.696408e-02 1.432 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.696408e-02 1.432 0 0
Rab regulation of trafficking R-HSA-9007101 4.151691e-02 1.382 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.909385e-02 1.408 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.660885e-02 1.436 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.829777e-02 1.417 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.767164e-02 1.424 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.688181e-02 1.433 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.255343e-02 1.371 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.255343e-02 1.371 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.261818e-02 1.370 0 0
Oncogene Induced Senescence R-HSA-2559585 4.542597e-02 1.343 0 0
Metabolism of RNA R-HSA-8953854 4.563675e-02 1.341 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.745107e-02 1.324 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.768675e-02 1.322 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.833246e-02 1.316 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.833246e-02 1.316 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.833246e-02 1.316 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.857937e-02 1.314 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.857937e-02 1.314 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.884606e-02 1.311 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.910379e-02 1.309 0 0
RET signaling R-HSA-8853659 5.074371e-02 1.295 0 0
SARS-CoV Infections R-HSA-9679506 5.159080e-02 1.287 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.241954e-02 1.281 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.279081e-02 1.277 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.279081e-02 1.277 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.300513e-02 1.276 0 0
Signaling by AXIN mutants R-HSA-4839735 5.301867e-02 1.276 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.301867e-02 1.276 0 0
Regulation of TP53 Expression R-HSA-6804754 5.414909e-02 1.266 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.398087e-02 1.194 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.398087e-02 1.194 0 0
mRNA 3'-end processing R-HSA-72187 5.756765e-02 1.240 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.398087e-02 1.194 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.312226e-02 1.200 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.844492e-02 1.233 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.275863e-02 1.202 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.669810e-02 1.246 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.696808e-02 1.244 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.644742e-02 1.248 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 5.414909e-02 1.266 0 0
Deubiquitination R-HSA-5688426 6.152558e-02 1.211 0 0
Host Interactions of HIV factors R-HSA-162909 6.244278e-02 1.205 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.398087e-02 1.194 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.397007e-02 1.194 0 0
Neurodegenerative Diseases R-HSA-8863678 6.397007e-02 1.194 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.391082e-02 1.268 0 0
Death Receptor Signaling R-HSA-73887 5.693249e-02 1.245 0 0
Influenza Infection R-HSA-168255 5.389313e-02 1.268 0 0
IRE1alpha activates chaperones R-HSA-381070 5.490534e-02 1.260 0 0
Interleukin-17 signaling R-HSA-448424 6.505091e-02 1.187 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.510795e-02 1.186 0 0
L1CAM interactions R-HSA-373760 6.550515e-02 1.184 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.558542e-02 1.183 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.584279e-02 1.181 0 0
HIV Life Cycle R-HSA-162587 6.592413e-02 1.181 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.776854e-02 1.169 0 0
PTK6 Expression R-HSA-8849473 6.776854e-02 1.169 0 0
SOS-mediated signalling R-HSA-112412 6.776854e-02 1.169 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.776854e-02 1.169 0 0
G1/S Transition R-HSA-69206 6.956110e-02 1.158 0 0
Signaling by VEGF R-HSA-194138 6.956110e-02 1.158 0 0
Drug resistance of KIT mutants R-HSA-9669937 8.877637e-02 1.052 0 0
KIT mutants bind TKIs R-HSA-9669921 8.877637e-02 1.052 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 8.877637e-02 1.052 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 8.877637e-02 1.052 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 8.877637e-02 1.052 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 8.877637e-02 1.052 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 8.877637e-02 1.052 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 8.877637e-02 1.052 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 8.877637e-02 1.052 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 8.877637e-02 1.052 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 8.877637e-02 1.052 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 8.877637e-02 1.052 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 8.877637e-02 1.052 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 7.970529e-02 1.099 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 7.970529e-02 1.099 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.970529e-02 1.099 0 0
Type I hemidesmosome assembly R-HSA-446107 8.444308e-02 1.073 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 8.444308e-02 1.073 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.444308e-02 1.073 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.444308e-02 1.073 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.576031e-02 1.121 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.643828e-02 1.063 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.643828e-02 1.063 0 0
Recycling pathway of L1 R-HSA-437239 7.537791e-02 1.123 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.215186e-02 1.142 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.215186e-02 1.142 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.358212e-02 1.078 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.511183e-02 1.124 0 0
Nucleotide Excision Repair R-HSA-5696398 8.541174e-02 1.068 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.049534e-02 1.094 0 0
Integrin signaling R-HSA-354192 7.516415e-02 1.124 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.320637e-02 1.080 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.643828e-02 1.063 0 0
Myogenesis R-HSA-525793 8.120388e-02 1.090 0 0
Adrenoceptors R-HSA-390696 8.444308e-02 1.073 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.563082e-02 1.067 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.229188e-02 1.141 0 0
Semaphorin interactions R-HSA-373755 7.215186e-02 1.142 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.511183e-02 1.124 0 0
Cell junction organization R-HSA-446728 7.173871e-02 1.144 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 7.970529e-02 1.099 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.444308e-02 1.073 0 0
Rap1 signalling R-HSA-392517 7.576031e-02 1.121 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.009734e-02 1.096 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.234711e-02 1.141 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.195397e-02 1.086 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.913544e-02 1.050 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.913544e-02 1.050 0 0
RAF activation R-HSA-5673000 9.171147e-02 1.038 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 9.352565e-02 1.029 0 0
HATs acetylate histones R-HSA-3214847 9.502931e-02 1.022 0 0
FOXO-mediated transcription R-HSA-9614085 9.502931e-02 1.022 0 0
Gene Silencing by RNA R-HSA-211000 9.519165e-02 1.021 0 0
Cell-Cell communication R-HSA-1500931 9.750704e-02 1.011 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 9.785859e-02 1.009 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.785859e-02 1.009 0 0
EPH-Ephrin signaling R-HSA-2682334 1.000922e-01 1.000 0 0
HIV elongation arrest and recovery R-HSA-167287 1.007703e-01 0.997 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.007703e-01 0.997 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.007703e-01 0.997 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.026716e-01 0.989 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.054091e-01 0.977 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.081794e-01 0.966 0 0
Regulation of gap junction activity R-HSA-191650 1.081794e-01 0.966 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.081794e-01 0.966 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.081794e-01 0.966 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.081794e-01 0.966 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.081794e-01 0.966 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.388527e-01 0.857 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.388527e-01 0.857 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.388527e-01 0.857 0 0
IRS activation R-HSA-74713 1.388527e-01 0.857 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 1.388527e-01 0.857 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 1.388527e-01 0.857 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.388527e-01 0.857 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.222988e-01 0.913 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.222988e-01 0.913 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.431623e-01 0.844 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.431623e-01 0.844 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.431623e-01 0.844 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.183002e-01 0.927 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.183002e-01 0.927 0 0
Phosphorylation of the APC/C R-HSA-176412 1.183002e-01 0.927 0 0
Disorders of Developmental Biology R-HSA-9675151 1.342434e-01 0.872 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.342434e-01 0.872 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.342434e-01 0.872 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.225804e-01 0.912 0 0
G1/S-Specific Transcription R-HSA-69205 1.101301e-01 0.958 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.351247e-01 0.869 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.398171e-01 0.854 0 0
HCMV Early Events R-HSA-9609690 1.101210e-01 0.958 0 0
Prolonged ERK activation events R-HSA-169893 1.183002e-01 0.927 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.388576e-01 0.857 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.351247e-01 0.869 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.351247e-01 0.869 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.318855e-01 0.880 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.342434e-01 0.872 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.081794e-01 0.966 0 0
Regulation of CDH11 function R-HSA-9762292 1.222988e-01 0.913 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.236379e-01 0.908 0 0
Signaling by RAS mutants R-HSA-6802949 1.351247e-01 0.869 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.101301e-01 0.958 0 0
RNA Polymerase III Transcription R-HSA-74158 1.101301e-01 0.958 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.342434e-01 0.872 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.228279e-01 0.911 0 0
Signal attenuation R-HSA-74749 1.222988e-01 0.913 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.183002e-01 0.927 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.116500e-01 0.952 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.200219e-01 0.921 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.114025e-01 0.953 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.222988e-01 0.913 0 0
ESR-mediated signaling R-HSA-8939211 1.254488e-01 0.902 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.227915e-01 0.911 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.081794e-01 0.966 0 0
Signaling by APC mutants R-HSA-4839744 1.431623e-01 0.844 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.149411e-01 0.940 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.255223e-01 0.901 0 0
Interferon Signaling R-HSA-913531 1.269863e-01 0.896 0 0
RUNX2 regulates bone development R-HSA-8941326 1.101301e-01 0.958 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.364544e-01 0.865 0 0
Glucose metabolism R-HSA-70326 1.103605e-01 0.957 0 0
Signaling by Leptin R-HSA-2586552 1.222988e-01 0.913 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.431623e-01 0.844 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.444244e-01 0.840 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.446921e-01 0.840 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.446921e-01 0.840 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.446921e-01 0.840 0 0
MHC class II antigen presentation R-HSA-2132295 1.451795e-01 0.838 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.461132e-01 0.835 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.461737e-01 0.835 0 0
Adipogenesis R-HSA-9843745 1.488302e-01 0.827 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.504275e-01 0.823 0 0
Aggrephagy R-HSA-9646399 1.522869e-01 0.817 0 0
Co-stimulation by CD28 R-HSA-389356 1.554001e-01 0.809 0 0
Centrosome maturation R-HSA-380287 1.564172e-01 0.806 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.591913e-01 0.798 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.591913e-01 0.798 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.591913e-01 0.798 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.696763e-01 0.770 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.433981e-01 0.614 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.433981e-01 0.614 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.433981e-01 0.614 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.433981e-01 0.614 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.433981e-01 0.614 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.433981e-01 0.614 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 2.433981e-01 0.614 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.433981e-01 0.614 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.433981e-01 0.614 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.711108e-01 0.767 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 1.711108e-01 0.767 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.711108e-01 0.767 0 0
CREB phosphorylation R-HSA-199920 2.044312e-01 0.689 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.044312e-01 0.689 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.650971e-01 0.782 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.650971e-01 0.782 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.383714e-01 0.623 0 0
Recycling of eIF2:GDP R-HSA-72731 2.383714e-01 0.623 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.879395e-01 0.726 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.879395e-01 0.726 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.879395e-01 0.726 0 0
Pervasive developmental disorders R-HSA-9005895 1.879395e-01 0.726 0 0
Disorders of Nervous System Development R-HSA-9697154 1.879395e-01 0.726 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.879395e-01 0.726 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.879395e-01 0.726 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.879395e-01 0.726 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.879395e-01 0.726 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.879395e-01 0.726 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.879395e-01 0.726 0 0
Ephrin signaling R-HSA-3928664 1.685121e-01 0.773 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.357116e-01 0.628 0 0
Regulation of KIT signaling R-HSA-1433559 2.357116e-01 0.628 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.357116e-01 0.628 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.054630e-01 0.687 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.803585e-01 0.744 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.960931e-01 0.708 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.960931e-01 0.708 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.960931e-01 0.708 0 0
Striated Muscle Contraction R-HSA-390522 1.723429e-01 0.764 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.758036e-01 0.755 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.288746e-01 0.640 0 0
Orc1 removal from chromatin R-HSA-68949 1.998899e-01 0.699 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.872723e-01 0.728 0 0
Meiotic synapsis R-HSA-1221632 2.117498e-01 0.674 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.981097e-01 0.703 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.350371e-01 0.629 0 0
mRNA Splicing R-HSA-72172 2.049143e-01 0.688 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.137208e-01 0.670 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.350371e-01 0.629 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.803650e-01 0.744 1 1
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.879395e-01 0.726 0 0
TGFBR3 expression R-HSA-9839394 1.651221e-01 0.782 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.768318e-01 0.752 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.357116e-01 0.628 0 0
Frs2-mediated activation R-HSA-170968 2.115291e-01 0.675 0 0
MAP2K and MAPK activation R-HSA-5674135 1.758036e-01 0.755 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.634188e-01 0.787 0 0
Specification of the neural plate border R-HSA-9834899 1.866904e-01 0.729 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.954013e-01 0.709 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.685121e-01 0.773 0 0
NF-kB is activated and signals survival R-HSA-209560 1.650971e-01 0.782 0 0
Activation of RAC1 R-HSA-428540 1.650971e-01 0.782 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.879395e-01 0.726 0 0
Regulation of IFNG signaling R-HSA-877312 1.879395e-01 0.726 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.142622e-01 0.669 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.326664e-01 0.633 0 0
Synthesis of DNA R-HSA-69239 2.238751e-01 0.650 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.822619e-01 0.739 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.044312e-01 0.689 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.247525e-01 0.648 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.960931e-01 0.708 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.822619e-01 0.739 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.048922e-01 0.688 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.723429e-01 0.764 0 0
Selective autophagy R-HSA-9663891 1.981097e-01 0.703 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.048922e-01 0.688 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.866904e-01 0.729 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.666655e-01 0.778 0 0
HDACs deacetylate histones R-HSA-3214815 2.362415e-01 0.627 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.326664e-01 0.633 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.415955e-01 0.617 0 0
Signaling by MET R-HSA-6806834 2.019434e-01 0.695 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.288746e-01 0.640 0 0
HIV Infection R-HSA-162906 2.237401e-01 0.650 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.112931e-01 0.675 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.433981e-01 0.614 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.433981e-01 0.614 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.433981e-01 0.614 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.650971e-01 0.782 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.383714e-01 0.623 0 0
Signaling by LTK R-HSA-9842663 1.879395e-01 0.726 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.288746e-01 0.640 0 0
TBC/RABGAPs R-HSA-8854214 2.007568e-01 0.697 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.357116e-01 0.628 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.635092e-01 0.786 0 0
Kinesins R-HSA-983189 1.872723e-01 0.728 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.067288e-01 0.685 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.711108e-01 0.767 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.383714e-01 0.623 0 0
Heme signaling R-HSA-9707616 2.089294e-01 0.680 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.433981e-01 0.614 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.383714e-01 0.623 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.116298e-01 0.674 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.383714e-01 0.623 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.383714e-01 0.623 0 0
Signaling by NOTCH3 R-HSA-9012852 2.362415e-01 0.627 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.685121e-01 0.773 0 0
tRNA processing R-HSA-72306 2.347618e-01 0.629 0 0
FLT3 Signaling R-HSA-9607240 1.638560e-01 0.786 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.247525e-01 0.648 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.861422e-01 0.730 0 0
MET promotes cell motility R-HSA-8875878 2.439612e-01 0.613 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.444817e-01 0.612 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.458283e-01 0.609 0 0
Interleukin-37 signaling R-HSA-9008059 2.458283e-01 0.609 0 0
Developmental Biology R-HSA-1266738 2.483021e-01 0.605 0 0
Signaling by EGFR R-HSA-177929 2.488385e-01 0.604 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.506563e-01 0.601 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.506563e-01 0.601 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.523814e-01 0.598 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.549874e-01 0.593 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.563066e-01 0.591 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.563253e-01 0.591 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.563253e-01 0.591 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.580008e-01 0.588 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.592417e-01 0.586 0 0
Erythropoietin activates RAS R-HSA-9027284 2.603402e-01 0.584 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.603402e-01 0.584 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.603402e-01 0.584 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.603402e-01 0.584 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.603402e-01 0.584 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.612313e-01 0.583 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.105785e-01 0.508 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.105785e-01 0.508 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.105785e-01 0.508 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.105785e-01 0.508 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.105785e-01 0.508 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.105785e-01 0.508 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.717973e-01 0.430 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 3.717973e-01 0.430 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.717973e-01 0.430 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 3.717973e-01 0.430 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.717973e-01 0.430 0 0
MET activates PTPN11 R-HSA-8865999 3.717973e-01 0.430 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 3.717973e-01 0.430 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.725590e-01 0.565 0 0
MET receptor recycling R-HSA-8875656 2.725590e-01 0.565 0 0
ARMS-mediated activation R-HSA-170984 3.066828e-01 0.513 0 0
Lipophagy R-HSA-9613354 3.066828e-01 0.513 0 0
WNT mediated activation of DVL R-HSA-201688 3.066828e-01 0.513 0 0
Calcineurin activates NFAT R-HSA-2025928 3.066828e-01 0.513 0 0
HCN channels R-HSA-1296061 4.275834e-01 0.369 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.275834e-01 0.369 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.275834e-01 0.369 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.275834e-01 0.369 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.275834e-01 0.369 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.404849e-01 0.468 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.852765e-01 0.545 0 0
Notch-HLH transcription pathway R-HSA-350054 2.645745e-01 0.577 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.737535e-01 0.427 0 0
Defective F9 activation R-HSA-9673221 4.784185e-01 0.320 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.355666e-01 0.474 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.355666e-01 0.474 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.355666e-01 0.474 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.055549e-01 0.515 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.055549e-01 0.515 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.063169e-01 0.391 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.063169e-01 0.391 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.747662e-01 0.561 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.856691e-01 0.414 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.380383e-01 0.358 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.247419e-01 0.280 0 0
Phosphorylation of Emi1 R-HSA-176417 5.247419e-01 0.280 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.247419e-01 0.280 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.247419e-01 0.280 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.247419e-01 0.280 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.247419e-01 0.280 0 0
Signaling by MAPK mutants R-HSA-9652817 5.247419e-01 0.280 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.746444e-01 0.561 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.224783e-01 0.491 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.688105e-01 0.329 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.688105e-01 0.329 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.261105e-01 0.487 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.348312e-01 0.362 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.348312e-01 0.362 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.408847e-01 0.467 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.408847e-01 0.467 0 0
Signaling by Erythropoietin R-HSA-9006335 4.094834e-01 0.388 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.094834e-01 0.388 0 0
Translation initiation complex formation R-HSA-72649 3.557401e-01 0.449 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.875646e-01 0.412 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.300420e-01 0.366 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.300420e-01 0.366 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.588665e-01 0.338 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.038965e-01 0.394 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.250627e-01 0.372 0 0
FGFR2 alternative splicing R-HSA-6803529 4.824532e-01 0.317 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.824532e-01 0.317 0 0
HIV Transcription Elongation R-HSA-167169 4.430275e-01 0.354 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.430275e-01 0.354 0 0
Transcription of the HIV genome R-HSA-167172 4.110329e-01 0.386 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.110329e-01 0.386 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.705276e-01 0.327 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.272029e-01 0.278 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.272029e-01 0.278 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.393809e-01 0.357 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.845577e-01 0.315 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.003230e-01 0.301 0 0
Dual Incision in GG-NER R-HSA-5696400 5.290815e-01 0.276 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.290815e-01 0.276 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.070141e-01 0.295 0 0
Chromosome Maintenance R-HSA-73886 3.774212e-01 0.423 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.606921e-01 0.443 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.525510e-01 0.344 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.525510e-01 0.344 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.286073e-01 0.368 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.747662e-01 0.561 0 0
Telomere Extension By Telomerase R-HSA-171319 3.887765e-01 0.410 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.968313e-01 0.527 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.286073e-01 0.368 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.286073e-01 0.368 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.471278e-01 0.460 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.281794e-01 0.484 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.038965e-01 0.394 0 0
G1 Phase R-HSA-69236 3.549146e-01 0.450 0 0
Cyclin D associated events in G1 R-HSA-69231 3.549146e-01 0.450 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.030370e-01 0.298 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.679728e-01 0.434 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.300420e-01 0.366 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.748284e-01 0.323 0 0
DNA Double Strand Break Response R-HSA-5693606 2.669928e-01 0.574 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.066828e-01 0.513 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.606921e-01 0.443 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.601135e-01 0.337 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.548613e-01 0.450 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.586502e-01 0.339 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.903713e-01 0.309 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.066828e-01 0.513 0 0
PI3K/AKT activation R-HSA-198203 3.404849e-01 0.468 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.852765e-01 0.545 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.679728e-01 0.434 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.364362e-01 0.360 0 0
Homology Directed Repair R-HSA-5693538 4.551531e-01 0.342 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.856691e-01 0.414 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.380383e-01 0.358 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.247419e-01 0.280 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.688105e-01 0.329 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.384776e-01 0.470 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.237489e-01 0.373 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.159162e-01 0.287 0 0
UCH proteinases R-HSA-5689603 3.807393e-01 0.419 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.805518e-01 0.420 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.056009e-01 0.296 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.380383e-01 0.358 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.525510e-01 0.344 0 0
Gap junction trafficking and regulation R-HSA-157858 4.364362e-01 0.360 0 0
Generation of second messenger molecules R-HSA-202433 4.430275e-01 0.354 0 0
IGF1R signaling cascade R-HSA-2428924 5.039241e-01 0.298 0 0
MET activates RAS signaling R-HSA-8851805 4.380383e-01 0.358 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.797869e-01 0.319 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 4.304381e-01 0.366 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.679728e-01 0.434 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.784185e-01 0.320 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.784185e-01 0.320 0 0
PTK6 Down-Regulation R-HSA-8849472 4.784185e-01 0.320 0 0
Activation of AKT2 R-HSA-165158 4.784185e-01 0.320 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.063169e-01 0.391 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.224783e-01 0.491 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.281030e-01 0.484 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.903713e-01 0.309 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.064169e-01 0.514 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.638187e-01 0.439 0 0
Signal transduction by L1 R-HSA-445144 4.104087e-01 0.387 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.182721e-01 0.285 0 0
Circadian clock R-HSA-9909396 3.064321e-01 0.514 0 0
Signaling by WNT in cancer R-HSA-4791275 2.806258e-01 0.552 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.038848e-01 0.394 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.275834e-01 0.369 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.275834e-01 0.369 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.275834e-01 0.369 0 0
DNA strand elongation R-HSA-69190 2.806258e-01 0.552 0 0
Polo-like kinase mediated events R-HSA-156711 3.606921e-01 0.443 0 0
G-protein beta:gamma signalling R-HSA-397795 2.983760e-01 0.525 0 0
Nuclear RNA decay R-HSA-9930044 4.903713e-01 0.309 0 0
Autophagy R-HSA-9612973 4.515628e-01 0.345 0 0
Signalling to ERKs R-HSA-187687 3.524863e-01 0.453 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.747662e-01 0.561 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.747662e-01 0.561 0 0
Meiosis R-HSA-1500620 3.658806e-01 0.437 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.066828e-01 0.513 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.985519e-01 0.302 1 1
Macroautophagy R-HSA-1632852 3.056797e-01 0.515 0 0
HCMV Infection R-HSA-9609646 4.551194e-01 0.342 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.773669e-01 0.557 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.785662e-01 0.555 0 0
Signaling by NOTCH R-HSA-157118 3.808994e-01 0.419 0 0
Cellular response to chemical stress R-HSA-9711123 2.897519e-01 0.538 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.074287e-01 0.512 0 0
Interleukin-33 signaling R-HSA-9014843 3.105785e-01 0.508 0 0
MET interacts with TNS proteins R-HSA-8875513 3.717973e-01 0.430 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.275834e-01 0.369 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.404849e-01 0.468 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 3.737535e-01 0.427 0 0
Bicarbonate transporters R-HSA-425381 3.737535e-01 0.427 0 0
vRNP Assembly R-HSA-192905 3.737535e-01 0.427 0 0
Reelin signalling pathway R-HSA-8866376 4.784185e-01 0.320 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.784185e-01 0.320 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.055549e-01 0.515 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.055549e-01 0.515 0 0
PKB-mediated events R-HSA-109703 5.247419e-01 0.280 0 0
PDE3B signalling R-HSA-165160 5.247419e-01 0.280 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.247419e-01 0.280 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.247419e-01 0.280 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.688105e-01 0.329 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.430275e-01 0.354 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.099000e-01 0.293 0 0
DNA Repair R-HSA-73894 4.106995e-01 0.386 0 0
Adherens junctions interactions R-HSA-418990 3.722363e-01 0.429 0 0
Cell-cell junction organization R-HSA-421270 3.849136e-01 0.415 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.865469e-01 0.413 0 0
EGFR downregulation R-HSA-182971 4.504046e-01 0.346 0 0
Signaling by FGFR in disease R-HSA-1226099 4.935381e-01 0.307 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.038965e-01 0.394 0 0
Signaling by TGFBR3 R-HSA-9839373 3.875646e-01 0.412 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.784185e-01 0.320 0 0
G2/M Transition R-HSA-69275 2.780461e-01 0.556 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.504046e-01 0.346 0 0
HDMs demethylate histones R-HSA-3214842 3.263009e-01 0.486 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.457181e-01 0.351 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.784185e-01 0.320 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.905021e-01 0.537 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.658806e-01 0.437 0 0
Regulation of beta-cell development R-HSA-186712 2.878161e-01 0.541 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.263009e-01 0.486 0 0
Neurexins and neuroligins R-HSA-6794361 3.261105e-01 0.487 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.281794e-01 0.484 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.677776e-01 0.434 0 0
Diseases of programmed cell death R-HSA-9645723 4.149057e-01 0.382 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.717973e-01 0.430 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.066828e-01 0.513 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.066828e-01 0.513 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.275834e-01 0.369 0 0
NADE modulates death signalling R-HSA-205025 4.275834e-01 0.369 0 0
Interleukin-36 pathway R-HSA-9014826 4.784185e-01 0.320 0 0
Syndecan interactions R-HSA-3000170 2.849563e-01 0.545 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.247419e-01 0.280 0 0
Signal regulatory protein family interactions R-HSA-391160 4.985519e-01 0.302 0 0
Histamine receptors R-HSA-390650 3.717973e-01 0.430 0 0
Suppression of apoptosis R-HSA-9635465 3.737535e-01 0.427 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.079592e-01 0.294 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.845577e-01 0.315 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.903713e-01 0.309 0 0
Signaling by TGFB family members R-HSA-9006936 4.885017e-01 0.311 0 0
The NLRP1 inflammasome R-HSA-844455 3.717973e-01 0.430 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.275834e-01 0.369 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.852765e-01 0.545 0 0
Anchoring fibril formation R-HSA-2214320 4.063169e-01 0.391 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.247419e-01 0.280 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.688105e-01 0.329 0 0
Formation of axial mesoderm R-HSA-9796292 4.688105e-01 0.329 0 0
PKR-mediated signaling R-HSA-9833482 3.057666e-01 0.515 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.055385e-01 0.296 0 0
Potential therapeutics for SARS R-HSA-9679191 3.959914e-01 0.402 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.348312e-01 0.362 0 0
Maturation of nucleoprotein R-HSA-9683610 4.688105e-01 0.329 0 0
Protein methylation R-HSA-8876725 5.272029e-01 0.278 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.524863e-01 0.453 0 0
Signaling by ROBO receptors R-HSA-376176 4.107395e-01 0.386 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.888458e-01 0.410 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.959640e-01 0.305 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.105785e-01 0.508 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.725590e-01 0.565 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.784185e-01 0.320 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.355666e-01 0.474 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.063169e-01 0.391 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.247419e-01 0.280 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.688105e-01 0.329 0 0
LDL clearance R-HSA-8964038 4.824532e-01 0.317 0 0
Growth hormone receptor signaling R-HSA-982772 2.849563e-01 0.545 0 0
Signaling by Interleukins R-HSA-449147 3.668969e-01 0.435 0 0
Physiological factors R-HSA-5578768 4.985519e-01 0.302 1 1
Signaling by ALK R-HSA-201556 4.250627e-01 0.372 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.290815e-01 0.276 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.737535e-01 0.427 0 0
Zinc transporters R-HSA-435354 4.985519e-01 0.302 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.247419e-01 0.280 0 0
OAS antiviral response R-HSA-8983711 4.380383e-01 0.358 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.711229e-01 0.567 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.694181e-01 0.432 0 0
Interleukin-12 signaling R-HSA-9020591 5.203746e-01 0.284 0 0
Gap junction trafficking R-HSA-190828 5.301803e-01 0.276 0 0
Amine ligand-binding receptors R-HSA-375280 5.301803e-01 0.276 0 0
Netrin-1 signaling R-HSA-373752 5.301803e-01 0.276 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.313189e-01 0.275 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.358385e-01 0.271 0 0
Viral Infection Pathways R-HSA-9824446 5.432526e-01 0.265 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.465136e-01 0.262 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.465136e-01 0.262 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.465136e-01 0.262 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.468943e-01 0.262 0 0
Nucleosome assembly R-HSA-774815 5.468943e-01 0.262 0 0
DAG and IP3 signaling R-HSA-1489509 5.468943e-01 0.262 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.475154e-01 0.262 0 0
PERK regulates gene expression R-HSA-381042 5.478874e-01 0.261 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.500315e-01 0.260 0 0
Tight junction interactions R-HSA-420029 5.500315e-01 0.260 0 0
Laminin interactions R-HSA-3000157 5.500315e-01 0.260 0 0
SLC transporter disorders R-HSA-5619102 5.519007e-01 0.258 0 0
Killing mechanisms R-HSA-9664420 5.547227e-01 0.256 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.547227e-01 0.256 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.547227e-01 0.256 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.547227e-01 0.256 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.547227e-01 0.256 0 0
Differentiation of T cells R-HSA-9945266 5.547227e-01 0.256 0 0
Negative regulation of FLT3 R-HSA-9706369 5.547227e-01 0.256 0 0
IRS-mediated signalling R-HSA-112399 5.614847e-01 0.251 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.633187e-01 0.249 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.633187e-01 0.249 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.662930e-01 0.247 0 0
GPVI-mediated activation cascade R-HSA-114604 5.662930e-01 0.247 0 0
Calmodulin induced events R-HSA-111933 5.662930e-01 0.247 0 0
CaM pathway R-HSA-111997 5.662930e-01 0.247 0 0
Signaling by WNT R-HSA-195721 5.669089e-01 0.246 0 0
Signaling by LTK in cancer R-HSA-9842640 5.669536e-01 0.246 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.669536e-01 0.246 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.669536e-01 0.246 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.669536e-01 0.246 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.669536e-01 0.246 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.669536e-01 0.246 0 0
Neurofascin interactions R-HSA-447043 5.669536e-01 0.246 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.669536e-01 0.246 0 0
Cilium Assembly R-HSA-5617833 5.699838e-01 0.244 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.713706e-01 0.243 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.713706e-01 0.243 0 0
Metalloprotease DUBs R-HSA-5689901 5.713706e-01 0.243 0 0
TRP channels R-HSA-3295583 5.713706e-01 0.243 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.739936e-01 0.241 0 0
Dual incision in TC-NER R-HSA-6782135 5.762176e-01 0.239 0 0
Toll-like Receptor Cascades R-HSA-168898 5.782515e-01 0.238 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.810862e-01 0.236 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.810862e-01 0.236 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.810862e-01 0.236 0 0
Fibronectin matrix formation R-HSA-1566977 5.810862e-01 0.236 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.842767e-01 0.233 0 0
Collagen chain trimerization R-HSA-8948216 5.842767e-01 0.233 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.850358e-01 0.233 0 0
Extension of Telomeres R-HSA-180786 5.906991e-01 0.229 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.920698e-01 0.228 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.920698e-01 0.228 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.920698e-01 0.228 0 0
Insulin processing R-HSA-264876 5.920698e-01 0.228 0 0
Interleukin-1 signaling R-HSA-9020702 5.930281e-01 0.227 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.930281e-01 0.227 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.949817e-01 0.225 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.952300e-01 0.225 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.018203e-01 0.221 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.018203e-01 0.221 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 6.020400e-01 0.220 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 6.020400e-01 0.220 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.054184e-01 0.218 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.054184e-01 0.218 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.054184e-01 0.218 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.054184e-01 0.218 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.054184e-01 0.218 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.054184e-01 0.218 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.054184e-01 0.218 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.054184e-01 0.218 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.054184e-01 0.218 0 0
Opsins R-HSA-419771 6.054184e-01 0.218 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.054184e-01 0.218 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.054184e-01 0.218 0 0
VLDL clearance R-HSA-8964046 6.054184e-01 0.218 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.054184e-01 0.218 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.054184e-01 0.218 0 0
Regulation of PTEN localization R-HSA-8948747 6.054184e-01 0.218 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.054184e-01 0.218 0 0
CHL1 interactions R-HSA-447041 6.054184e-01 0.218 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.062816e-01 0.217 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.062816e-01 0.217 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.062816e-01 0.217 0 0
Specification of primordial germ cells R-HSA-9827857 6.062816e-01 0.217 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.062816e-01 0.217 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.062816e-01 0.217 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.062816e-01 0.217 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.062816e-01 0.217 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.065795e-01 0.217 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.106876e-01 0.214 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.106876e-01 0.214 0 0
DNA Damage Bypass R-HSA-73893 6.106876e-01 0.214 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.121101e-01 0.213 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.121101e-01 0.213 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.121101e-01 0.213 0 0
Interleukin-1 family signaling R-HSA-446652 6.149246e-01 0.211 0 0
Stabilization of p53 R-HSA-69541 6.189085e-01 0.208 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.189085e-01 0.208 0 0
PI3K Cascade R-HSA-109704 6.257968e-01 0.204 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.257968e-01 0.204 0 0
GAB1 signalosome R-HSA-180292 6.303086e-01 0.200 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.303086e-01 0.200 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.303086e-01 0.200 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.303086e-01 0.200 0 0
Mismatch Repair R-HSA-5358508 6.303086e-01 0.200 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.303086e-01 0.200 0 0
Tie2 Signaling R-HSA-210993 6.303086e-01 0.200 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.303086e-01 0.200 0 0
Platelet sensitization by LDL R-HSA-432142 6.303086e-01 0.200 0 0
Late endosomal microautophagy R-HSA-9615710 6.314779e-01 0.200 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.314779e-01 0.200 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.314779e-01 0.200 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.314779e-01 0.200 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.325228e-01 0.199 0 0
Signaling by PDGF R-HSA-186797 6.325228e-01 0.199 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.355290e-01 0.197 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.355290e-01 0.197 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.363033e-01 0.196 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.363033e-01 0.196 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.383352e-01 0.195 0 0
Signaling by NOTCH4 R-HSA-9013694 6.390114e-01 0.194 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.404687e-01 0.194 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.404687e-01 0.194 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.404687e-01 0.194 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.404687e-01 0.194 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.404687e-01 0.194 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.404687e-01 0.194 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.404687e-01 0.194 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.404687e-01 0.194 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.404687e-01 0.194 0 0
Alpha-defensins R-HSA-1462054 6.404687e-01 0.194 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.404687e-01 0.194 0 0
Sodium/Proton exchangers R-HSA-425986 6.404687e-01 0.194 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.458925e-01 0.190 0 0
DAP12 signaling R-HSA-2424491 6.501641e-01 0.187 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.501641e-01 0.187 0 0
Protein ubiquitination R-HSA-8852135 6.513057e-01 0.186 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.531757e-01 0.185 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.531757e-01 0.185 0 0
Crosslinking of collagen fibrils R-HSA-2243919 6.531757e-01 0.185 0 0
Regulation of signaling by CBL R-HSA-912631 6.531757e-01 0.185 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.531757e-01 0.185 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.531757e-01 0.185 0 0
Diseases of hemostasis R-HSA-9671793 6.531757e-01 0.185 0 0
Maturation of nucleoprotein R-HSA-9694631 6.531757e-01 0.185 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.549311e-01 0.184 0 0
Insulin receptor signalling cascade R-HSA-74751 6.589638e-01 0.181 0 0
Signaling by NOTCH1 R-HSA-1980143 6.633479e-01 0.178 0 0
MAPK family signaling cascades R-HSA-5683057 6.668328e-01 0.176 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.670783e-01 0.176 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.673302e-01 0.176 0 0
HIV Transcription Initiation R-HSA-167161 6.673302e-01 0.176 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.673302e-01 0.176 0 0
Post NMDA receptor activation events R-HSA-438064 6.678780e-01 0.175 0 0
Interleukin-12 family signaling R-HSA-447115 6.678780e-01 0.175 0 0
Trafficking of AMPA receptors R-HSA-399719 6.681640e-01 0.175 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.681640e-01 0.175 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.681640e-01 0.175 0 0
Downstream signal transduction R-HSA-186763 6.681640e-01 0.175 0 0
Mitochondrial biogenesis R-HSA-1592230 6.720853e-01 0.173 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.724074e-01 0.172 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.724074e-01 0.172 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.724074e-01 0.172 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.724074e-01 0.172 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.724074e-01 0.172 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.724074e-01 0.172 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.724074e-01 0.172 0 0
Interleukin-1 processing R-HSA-448706 6.724074e-01 0.172 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.724074e-01 0.172 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.724074e-01 0.172 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.724074e-01 0.172 0 0
Telomere Maintenance R-HSA-157579 6.724463e-01 0.172 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.748996e-01 0.171 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.748996e-01 0.171 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.748996e-01 0.171 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.748996e-01 0.171 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.748996e-01 0.171 0 0
Formation of definitive endoderm R-HSA-9823730 6.748996e-01 0.171 0 0
Negative regulation of MET activity R-HSA-6807004 6.748996e-01 0.171 0 0
Protein hydroxylation R-HSA-9629569 6.748996e-01 0.171 0 0
Peptide chain elongation R-HSA-156902 6.788613e-01 0.168 0 0
Ca-dependent events R-HSA-111996 6.824989e-01 0.166 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.854767e-01 0.164 0 0
Gastrulation R-HSA-9758941 6.863000e-01 0.163 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.939234e-01 0.159 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.955028e-01 0.158 0 0
ERK/MAPK targets R-HSA-198753 6.955028e-01 0.158 0 0
Basigin interactions R-HSA-210991 6.955028e-01 0.158 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.958198e-01 0.158 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.963331e-01 0.157 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.971752e-01 0.157 0 0
Signaling by SCF-KIT R-HSA-1433557 6.971752e-01 0.157 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.015105e-01 0.154 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.015105e-01 0.154 0 0
DNA replication initiation R-HSA-68952 7.015105e-01 0.154 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.015105e-01 0.154 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.015105e-01 0.154 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.015105e-01 0.154 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.015105e-01 0.154 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.015105e-01 0.154 0 0
2-LTR circle formation R-HSA-164843 7.015105e-01 0.154 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.015105e-01 0.154 0 0
Pexophagy R-HSA-9664873 7.015105e-01 0.154 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.015105e-01 0.154 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.015105e-01 0.154 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.015105e-01 0.154 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.021046e-01 0.154 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.021046e-01 0.154 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.021046e-01 0.154 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.021046e-01 0.154 0 0
Reproduction R-HSA-1474165 7.033613e-01 0.153 0 0
Ion homeostasis R-HSA-5578775 7.086825e-01 0.150 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.086825e-01 0.150 0 0
RMTs methylate histone arginines R-HSA-3214858 7.113584e-01 0.148 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.150128e-01 0.146 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.150128e-01 0.146 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.150128e-01 0.146 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.150128e-01 0.146 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.150128e-01 0.146 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.150128e-01 0.146 0 0
Serine metabolism R-HSA-977347 7.150128e-01 0.146 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.150128e-01 0.146 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.150128e-01 0.146 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.150128e-01 0.146 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.180533e-01 0.144 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.180533e-01 0.144 0 0
DNA Replication R-HSA-69306 7.182965e-01 0.144 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.219002e-01 0.142 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.250494e-01 0.140 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.260315e-01 0.139 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.280298e-01 0.138 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.280298e-01 0.138 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.280298e-01 0.138 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.280298e-01 0.138 0 0
Synthesis of PI R-HSA-1483226 7.280298e-01 0.138 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.280298e-01 0.138 0 0
PECAM1 interactions R-HSA-210990 7.280298e-01 0.138 0 0
Transport of RCbl within the body R-HSA-9758890 7.280298e-01 0.138 0 0
Interleukin-2 signaling R-HSA-9020558 7.280298e-01 0.138 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.308650e-01 0.136 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.308650e-01 0.136 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.308650e-01 0.136 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.326776e-01 0.135 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.332478e-01 0.135 0 0
Signaling by NOTCH2 R-HSA-1980145 7.333307e-01 0.135 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.333307e-01 0.135 0 0
Mitophagy R-HSA-5205647 7.333307e-01 0.135 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.333307e-01 0.135 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.333307e-01 0.135 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.333307e-01 0.135 0 0
Signaling by KIT in disease R-HSA-9669938 7.334614e-01 0.135 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.334614e-01 0.135 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.334614e-01 0.135 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.334614e-01 0.135 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.334614e-01 0.135 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.334614e-01 0.135 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.382508e-01 0.132 0 0
Diseases of DNA repair R-HSA-9675135 7.382508e-01 0.132 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.403352e-01 0.131 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.479472e-01 0.126 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.479472e-01 0.126 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.479472e-01 0.126 0 0
HCMV Late Events R-HSA-9610379 7.481845e-01 0.126 0 0
RSV-host interactions R-HSA-9833110 7.492000e-01 0.125 0 0
Collagen formation R-HSA-1474290 7.492577e-01 0.125 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.508831e-01 0.124 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.508831e-01 0.124 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.508831e-01 0.124 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.508831e-01 0.124 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.508831e-01 0.124 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.508831e-01 0.124 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.509669e-01 0.124 0 0
Synthesis of PC R-HSA-1483191 7.509669e-01 0.124 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.521944e-01 0.124 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.521944e-01 0.124 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.521944e-01 0.124 0 0
Integration of provirus R-HSA-162592 7.521944e-01 0.124 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.521944e-01 0.124 0 0
Plasmalogen biosynthesis R-HSA-75896 7.521944e-01 0.124 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.521944e-01 0.124 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.521944e-01 0.124 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.521944e-01 0.124 0 0
Cellular response to starvation R-HSA-9711097 7.553194e-01 0.122 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.583690e-01 0.120 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.597956e-01 0.119 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.605759e-01 0.119 0 0
FLT3 signaling in disease R-HSA-9682385 7.619151e-01 0.118 0 0
Interferon gamma signaling R-HSA-877300 7.623183e-01 0.118 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.639451e-01 0.117 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.670005e-01 0.115 0 0
PLC beta mediated events R-HSA-112043 7.672105e-01 0.115 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.672428e-01 0.115 0 0
Mitochondrial RNA degradation R-HSA-9836573 7.673146e-01 0.115 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.673146e-01 0.115 0 0
Developmental Cell Lineages R-HSA-9734767 7.689703e-01 0.114 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.742132e-01 0.111 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.742132e-01 0.111 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.742132e-01 0.111 0 0
Repression of WNT target genes R-HSA-4641265 7.742132e-01 0.111 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.742132e-01 0.111 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.742132e-01 0.111 0 0
Polymerase switching R-HSA-69091 7.742132e-01 0.111 0 0
Leading Strand Synthesis R-HSA-69109 7.742132e-01 0.111 0 0
Interleukin-15 signaling R-HSA-8983432 7.742132e-01 0.111 0 0
Degradation of CDH1 R-HSA-9766229 7.749654e-01 0.111 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.758799e-01 0.110 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.820569e-01 0.107 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.827944e-01 0.106 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.827944e-01 0.106 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.827944e-01 0.106 0 0
Long-term potentiation R-HSA-9620244 7.827944e-01 0.106 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.827944e-01 0.106 0 0
Hyaluronan degradation R-HSA-2160916 7.827944e-01 0.106 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.827944e-01 0.106 0 0
Interleukin-7 signaling R-HSA-1266695 7.827944e-01 0.106 0 0
Ub-specific processing proteases R-HSA-5689880 7.834378e-01 0.106 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.879620e-01 0.103 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.879620e-01 0.103 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.879620e-01 0.103 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.913542e-01 0.102 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.924486e-01 0.101 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.942768e-01 0.100 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.942768e-01 0.100 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 7.942768e-01 0.100 0 0
Processing of SMDT1 R-HSA-8949664 7.942768e-01 0.100 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.942768e-01 0.100 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.942768e-01 0.100 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.942768e-01 0.100 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.942768e-01 0.100 0 0
rRNA modification in the mitochondrion R-HSA-6793080 7.942768e-01 0.100 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.942768e-01 0.100 0 0
MET activates PTK2 signaling R-HSA-8874081 7.973618e-01 0.098 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.973618e-01 0.098 0 0
Ion transport by P-type ATPases R-HSA-936837 7.977842e-01 0.098 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.023362e-01 0.096 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.074930e-01 0.093 0 0
PCP/CE pathway R-HSA-4086400 8.090326e-01 0.092 0 0
RNA Polymerase I Transcription R-HSA-73864 8.090326e-01 0.092 0 0
Integrin cell surface interactions R-HSA-216083 8.090326e-01 0.092 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.110567e-01 0.091 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.115980e-01 0.091 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.115980e-01 0.091 0 0
Interleukin-2 family signaling R-HSA-451927 8.115980e-01 0.091 0 0
Base Excision Repair R-HSA-73884 8.119664e-01 0.090 0 0
Removal of the Flap Intermediate R-HSA-69166 8.125585e-01 0.090 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.125585e-01 0.090 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.125585e-01 0.090 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.125585e-01 0.090 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.125585e-01 0.090 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.125585e-01 0.090 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.125585e-01 0.090 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.125585e-01 0.090 0 0
Prolactin receptor signaling R-HSA-1170546 8.125585e-01 0.090 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.125585e-01 0.090 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.125585e-01 0.090 0 0
Smooth Muscle Contraction R-HSA-445355 8.174465e-01 0.088 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.174465e-01 0.088 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.197451e-01 0.086 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.225558e-01 0.085 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.228152e-01 0.085 0 0
PI Metabolism R-HSA-1483255 8.228152e-01 0.085 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.237337e-01 0.084 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.239190e-01 0.084 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.239190e-01 0.084 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.239190e-01 0.084 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.239190e-01 0.084 0 0
Inflammasomes R-HSA-622312 8.239190e-01 0.084 0 0
G-protein mediated events R-HSA-112040 8.251068e-01 0.083 0 0
Signaling by FGFR2 R-HSA-5654738 8.255179e-01 0.083 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.269727e-01 0.083 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.292167e-01 0.081 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.292167e-01 0.081 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.292167e-01 0.081 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.292167e-01 0.081 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.292167e-01 0.081 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.292167e-01 0.081 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.292167e-01 0.081 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.292167e-01 0.081 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.292167e-01 0.081 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.292167e-01 0.081 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 8.292167e-01 0.081 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.292167e-01 0.081 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.329648e-01 0.079 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.329648e-01 0.079 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 8.335223e-01 0.079 0 0
Regulated Necrosis R-HSA-5218859 8.335223e-01 0.079 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.335223e-01 0.079 0 0
Signaling by Insulin receptor R-HSA-74752 8.345465e-01 0.079 0 0
mRNA Capping R-HSA-72086 8.359885e-01 0.078 0 0
DARPP-32 events R-HSA-180024 8.359885e-01 0.078 0 0
Platelet calcium homeostasis R-HSA-418360 8.359885e-01 0.078 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.380664e-01 0.077 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.428440e-01 0.074 0 0
Depyrimidination R-HSA-73928 8.428440e-01 0.074 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.443953e-01 0.073 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.443953e-01 0.073 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.443953e-01 0.073 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.443953e-01 0.073 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.443953e-01 0.073 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.443953e-01 0.073 0 0
Activation of SMO R-HSA-5635838 8.443953e-01 0.073 0 0
Signaling by FGFR1 R-HSA-5654736 8.447877e-01 0.073 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.447877e-01 0.073 0 0
TNF signaling R-HSA-75893 8.447877e-01 0.073 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.473046e-01 0.072 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.480968e-01 0.072 0 0
Platelet degranulation R-HSA-114608 8.482043e-01 0.071 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.486570e-01 0.071 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.493602e-01 0.071 0 0
Signaling by FGFR4 R-HSA-5654743 8.522126e-01 0.069 0 0
Regulation of CDH1 Function R-HSA-9764561 8.530998e-01 0.069 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.549204e-01 0.068 0 0
ECM proteoglycans R-HSA-3000178 8.567986e-01 0.067 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.567986e-01 0.067 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.572443e-01 0.067 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.579058e-01 0.067 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.582257e-01 0.066 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.582257e-01 0.066 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.582257e-01 0.066 0 0
Synthesis of PG R-HSA-1483148 8.582257e-01 0.066 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.582257e-01 0.066 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.582257e-01 0.066 0 0
DAP12 interactions R-HSA-2172127 8.610901e-01 0.065 0 0
Surfactant metabolism R-HSA-5683826 8.610901e-01 0.065 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.612422e-01 0.065 0 0
Eukaryotic Translation Termination R-HSA-72764 8.612422e-01 0.065 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.639276e-01 0.064 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.643202e-01 0.063 0 0
Muscle contraction R-HSA-397014 8.663727e-01 0.062 1 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.694958e-01 0.061 0 0
Signaling by FGFR3 R-HSA-5654741 8.694958e-01 0.061 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.694958e-01 0.061 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.708276e-01 0.060 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.708276e-01 0.060 0 0
Glycogen storage diseases R-HSA-3229121 8.708276e-01 0.060 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.708276e-01 0.060 0 0
Catecholamine biosynthesis R-HSA-209905 8.708276e-01 0.060 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.708276e-01 0.060 0 0
Choline catabolism R-HSA-6798163 8.708276e-01 0.060 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.708276e-01 0.060 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.708276e-01 0.060 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.757979e-01 0.058 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.757979e-01 0.058 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.757979e-01 0.058 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.757979e-01 0.058 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.757979e-01 0.058 0 0
Cardiogenesis R-HSA-9733709 8.771128e-01 0.057 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.774489e-01 0.057 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.774489e-01 0.057 0 0
TCR signaling R-HSA-202403 8.784683e-01 0.056 0 0
Signaling by FGFR R-HSA-190236 8.788666e-01 0.056 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.823100e-01 0.054 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.823100e-01 0.054 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.823100e-01 0.054 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.823100e-01 0.054 0 0
PKA activation R-HSA-163615 8.823100e-01 0.054 0 0
PKA activation in glucagon signalling R-HSA-164378 8.823100e-01 0.054 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.823100e-01 0.054 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.823100e-01 0.054 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 8.823100e-01 0.054 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.826587e-01 0.054 0 0
Collagen degradation R-HSA-1442490 8.826587e-01 0.054 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.826587e-01 0.054 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.845114e-01 0.053 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.857908e-01 0.053 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.870912e-01 0.052 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.886538e-01 0.051 0 0
Metal ion SLC transporters R-HSA-425410 8.920735e-01 0.050 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.927724e-01 0.049 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.927724e-01 0.049 0 0
Other interleukin signaling R-HSA-449836 8.927724e-01 0.049 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.927724e-01 0.049 0 0
The NLRP3 inflammasome R-HSA-844456 8.927724e-01 0.049 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.927724e-01 0.049 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.938978e-01 0.049 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.938978e-01 0.049 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.938978e-01 0.049 0 0
eNOS activation R-HSA-203615 8.938978e-01 0.049 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.938978e-01 0.049 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.938978e-01 0.049 0 0
Hyaluronan metabolism R-HSA-2142845 8.938978e-01 0.049 0 0
Selenocysteine synthesis R-HSA-2408557 8.945878e-01 0.048 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.952341e-01 0.048 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.953958e-01 0.048 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.003541e-01 0.046 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.012965e-01 0.045 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.014666e-01 0.045 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.023052e-01 0.045 0 0
Glycogen synthesis R-HSA-3322077 9.023052e-01 0.045 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.023052e-01 0.045 0 0
Signaling by NODAL R-HSA-1181150 9.023052e-01 0.045 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.023052e-01 0.045 0 0
Nephrin family interactions R-HSA-373753 9.023052e-01 0.045 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.025906e-01 0.045 0 0
Viral mRNA Translation R-HSA-192823 9.040817e-01 0.044 0 0
Sensory processing of sound R-HSA-9659379 9.058946e-01 0.043 0 0
Cellular response to hypoxia R-HSA-1234174 9.069012e-01 0.042 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.085289e-01 0.042 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.085289e-01 0.042 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.085289e-01 0.042 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.108607e-01 0.041 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.109911e-01 0.040 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.109911e-01 0.040 0 0
Lagging Strand Synthesis R-HSA-69186 9.109911e-01 0.040 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.109911e-01 0.040 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.109911e-01 0.040 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.109911e-01 0.040 0 0
Signalling to RAS R-HSA-167044 9.109911e-01 0.040 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.109911e-01 0.040 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.110830e-01 0.040 0 0
Degradation of AXIN R-HSA-4641257 9.151150e-01 0.039 0 0
Voltage gated Potassium channels R-HSA-1296072 9.151150e-01 0.039 0 0
Degradation of DVL R-HSA-4641258 9.151150e-01 0.039 0 0
NCAM1 interactions R-HSA-419037 9.151150e-01 0.039 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.167098e-01 0.038 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.189052e-01 0.037 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.189052e-01 0.037 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.189052e-01 0.037 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.189052e-01 0.037 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.189052e-01 0.037 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.199475e-01 0.036 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.204202e-01 0.036 0 0
Elastic fibre formation R-HSA-1566948 9.212535e-01 0.036 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.220102e-01 0.035 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.220102e-01 0.035 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.261160e-01 0.033 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.261160e-01 0.033 0 0
Ethanol oxidation R-HSA-71384 9.261160e-01 0.033 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.261160e-01 0.033 0 0
PPARA activates gene expression R-HSA-1989781 9.264645e-01 0.033 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.269720e-01 0.033 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.269720e-01 0.033 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.270001e-01 0.033 0 0
COPII-mediated vesicle transport R-HSA-204005 9.308896e-01 0.031 0 0
rRNA processing R-HSA-72312 9.314887e-01 0.031 0 0
Diseases of Immune System R-HSA-5260271 9.322967e-01 0.030 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.322967e-01 0.030 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.326860e-01 0.030 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.326860e-01 0.030 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.326860e-01 0.030 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.326860e-01 0.030 0 0
Carnitine shuttle R-HSA-200425 9.326860e-01 0.030 0 0
Formation of the ureteric bud R-HSA-9830674 9.326860e-01 0.030 0 0
Hedgehog 'on' state R-HSA-5632684 9.349579e-01 0.029 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.369103e-01 0.028 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.372523e-01 0.028 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.372523e-01 0.028 0 0
Maturation of spike protein R-HSA-9694548 9.372523e-01 0.028 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.375834e-01 0.028 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.386722e-01 0.027 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.386722e-01 0.027 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.386722e-01 0.027 0 0
Complex III assembly R-HSA-9865881 9.386722e-01 0.027 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.386722e-01 0.027 0 0
Formation of the cornified envelope R-HSA-6809371 9.417271e-01 0.026 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.418624e-01 0.026 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.418624e-01 0.026 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.418624e-01 0.026 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.418624e-01 0.026 0 0
Translation of Structural Proteins R-HSA-9683701 9.418624e-01 0.026 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.418624e-01 0.026 0 0
Ca2+ pathway R-HSA-4086398 9.424492e-01 0.026 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.441264e-01 0.025 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.441264e-01 0.025 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.452463e-01 0.024 0 0
Hemostasis R-HSA-109582 9.464541e-01 0.024 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.490958e-01 0.023 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.490958e-01 0.023 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.490958e-01 0.023 0 0
Urea cycle R-HSA-70635 9.490958e-01 0.023 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.490958e-01 0.023 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.490958e-01 0.023 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.490958e-01 0.023 0 0
Defective pyroptosis R-HSA-9710421 9.501336e-01 0.022 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.501336e-01 0.022 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.501336e-01 0.022 0 0
Packaging Of Telomere Ends R-HSA-171306 9.536234e-01 0.021 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.536234e-01 0.021 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.536234e-01 0.021 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.536234e-01 0.021 0 0
Cristae formation R-HSA-8949613 9.536234e-01 0.021 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.536234e-01 0.021 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.538356e-01 0.021 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.538356e-01 0.021 0 0
Translation of Structural Proteins R-HSA-9694635 9.551189e-01 0.020 0 0
Opioid Signalling R-HSA-111885 9.554754e-01 0.020 0 0
Neutrophil degranulation R-HSA-6798695 9.567919e-01 0.019 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.572739e-01 0.019 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.572739e-01 0.019 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.572739e-01 0.019 0 0
Mitochondrial protein import R-HSA-1268020 9.575105e-01 0.019 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.575105e-01 0.019 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.577487e-01 0.019 0 0
Insulin receptor recycling R-HSA-77387 9.577487e-01 0.019 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.577487e-01 0.019 0 0
Pyrimidine salvage R-HSA-73614 9.577487e-01 0.019 0 0
Pyroptosis R-HSA-5620971 9.577487e-01 0.019 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.603459e-01 0.018 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.604395e-01 0.018 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.604395e-01 0.018 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.604661e-01 0.018 0 0
Adaptive Immune System R-HSA-1280218 9.614434e-01 0.017 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.615071e-01 0.017 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.615071e-01 0.017 0 0
DNA methylation R-HSA-5334118 9.615071e-01 0.017 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.615071e-01 0.017 0 0
Cardiac conduction R-HSA-5576891 9.626803e-01 0.017 1 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.649315e-01 0.016 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.649315e-01 0.016 0 0
Neurotransmitter clearance R-HSA-112311 9.649315e-01 0.016 0 0
Gluconeogenesis R-HSA-70263 9.661773e-01 0.015 0 0
Stimuli-sensing channels R-HSA-2672351 9.662968e-01 0.015 0 0
Co-inhibition by PD-1 R-HSA-389948 9.677447e-01 0.014 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.678216e-01 0.014 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.680514e-01 0.014 0 0
Budding and maturation of HIV virion R-HSA-162588 9.680514e-01 0.014 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.680514e-01 0.014 0 0
Cargo concentration in the ER R-HSA-5694530 9.680514e-01 0.014 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.687265e-01 0.014 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.694844e-01 0.013 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.701169e-01 0.013 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.708939e-01 0.013 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.708939e-01 0.013 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.710901e-01 0.013 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.712886e-01 0.013 0 0
Phospholipid metabolism R-HSA-1483257 9.719749e-01 0.012 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.732808e-01 0.012 0 0
Meiotic recombination R-HSA-912446 9.732808e-01 0.012 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.734837e-01 0.012 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.734837e-01 0.012 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.734837e-01 0.012 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.753107e-01 0.011 0 0
Ribosome-associated quality control R-HSA-9948299 9.753161e-01 0.011 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.758432e-01 0.011 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.758432e-01 0.011 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.758432e-01 0.011 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.758432e-01 0.011 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.758432e-01 0.011 0 0
Heme degradation R-HSA-189483 9.758432e-01 0.011 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.760860e-01 0.011 0 0
Protein localization R-HSA-9609507 9.772714e-01 0.010 0 0
Pyruvate metabolism R-HSA-70268 9.778912e-01 0.010 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.778912e-01 0.010 0 0
Gap junction assembly R-HSA-190861 9.779928e-01 0.010 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.779928e-01 0.010 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.779928e-01 0.010 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.779928e-01 0.010 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.779928e-01 0.010 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.799513e-01 0.009 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.799513e-01 0.009 0 0
Regulation of Apoptosis R-HSA-169911 9.799513e-01 0.009 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.799513e-01 0.009 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.799513e-01 0.009 0 0
Paracetamol ADME R-HSA-9753281 9.805448e-01 0.009 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.817356e-01 0.008 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.824307e-01 0.008 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.833612e-01 0.007 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.833612e-01 0.007 0 0
Cleavage of the damaged purine R-HSA-110331 9.833612e-01 0.007 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.833612e-01 0.007 0 0
Metabolism of folate and pterines R-HSA-196757 9.833612e-01 0.007 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.842551e-01 0.007 0 0
Depurination R-HSA-73927 9.848422e-01 0.007 0 0
Biofilm formation R-HSA-9931953 9.848422e-01 0.007 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.849894e-01 0.007 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.849894e-01 0.007 0 0
Ion channel transport R-HSA-983712 9.851046e-01 0.007 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.851719e-01 0.006 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.851719e-01 0.006 0 0
Protein folding R-HSA-391251 9.851719e-01 0.006 0 0
Peroxisomal protein import R-HSA-9033241 9.858769e-01 0.006 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.858769e-01 0.006 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.861383e-01 0.006 0 0
Pentose phosphate pathway R-HSA-71336 9.861914e-01 0.006 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.861914e-01 0.006 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.861914e-01 0.006 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.863634e-01 0.006 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.866505e-01 0.006 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.869695e-01 0.006 0 0
Selenoamino acid metabolism R-HSA-2408522 9.871898e-01 0.006 0 0
Glycogen metabolism R-HSA-8982491 9.874207e-01 0.005 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.874207e-01 0.005 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.874207e-01 0.005 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.874207e-01 0.005 0 0
Integration of energy metabolism R-HSA-163685 9.878935e-01 0.005 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.882189e-01 0.005 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.885405e-01 0.005 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.885405e-01 0.005 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.885405e-01 0.005 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.885405e-01 0.005 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.895608e-01 0.005 0 0
Intra-Golgi traffic R-HSA-6811438 9.895608e-01 0.005 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.895608e-01 0.005 0 0
Parasite infection R-HSA-9664407 9.904099e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.904099e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.904099e-01 0.004 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.904902e-01 0.004 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.904902e-01 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.905541e-01 0.004 0 0
Defensins R-HSA-1461973 9.913370e-01 0.004 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.913370e-01 0.004 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.916865e-01 0.004 0 0
Hedgehog 'off' state R-HSA-5610787 9.919780e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.919780e-01 0.003 0 0
Proteasome assembly R-HSA-9907900 9.921084e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.921084e-01 0.003 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.924395e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.926167e-01 0.003 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.928111e-01 0.003 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.928111e-01 0.003 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.928111e-01 0.003 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.928111e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.928111e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.929829e-01 0.003 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.934513e-01 0.003 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.934513e-01 0.003 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.934513e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.942248e-01 0.003 0 0
ER-Phagosome pathway R-HSA-1236974 9.943957e-01 0.002 0 0
Intraflagellar transport R-HSA-5620924 9.945659e-01 0.002 0 0
GPER1 signaling R-HSA-9634597 9.945659e-01 0.002 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.946803e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.946803e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.948021e-01 0.002 0 0
Downstream TCR signaling R-HSA-202424 9.948021e-01 0.002 0 0
Platelet homeostasis R-HSA-418346 9.950808e-01 0.002 0 0
Azathioprine ADME R-HSA-9748787 9.954909e-01 0.002 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.954909e-01 0.002 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.956709e-01 0.002 0 0
Signaling by ERBB4 R-HSA-1236394 9.958455e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.958925e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.958925e-01 0.002 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.958925e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.961751e-01 0.002 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.962585e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.965918e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.970173e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.971702e-01 0.001 0 0
G alpha (z) signalling events R-HSA-418597 9.971721e-01 0.001 0 0
Neddylation R-HSA-8951664 9.973433e-01 0.001 0 0
Immune System R-HSA-168256 9.973888e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.974241e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.975730e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.976536e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.976536e-01 0.001 0 0
Amyloid fiber formation R-HSA-977225 9.976763e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.977582e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.977812e-01 0.001 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.978627e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.979145e-01 0.001 0 0
Sialic acid metabolism R-HSA-4085001 9.980532e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.982267e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.982267e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.982267e-01 0.001 0 0
Aquaporin-mediated transport R-HSA-445717 9.983848e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.983848e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.986599e-01 0.001 0 0
Signaling by Hedgehog R-HSA-5358351 9.987161e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.990777e-01 0.000 0 0
Kidney development R-HSA-9830369 9.990777e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.993421e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.993652e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.993652e-01 0.000 0 0
Neuronal System R-HSA-112316 9.994150e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.994734e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.994881e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.994901e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.994920e-01 0.000 0 0
Translation R-HSA-72766 9.995017e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.995204e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.995666e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.995842e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.996092e-01 0.000 0 0
Keratinization R-HSA-6805567 9.996339e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.996700e-01 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 9.997194e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.997905e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.997905e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.998054e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998515e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998704e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.998970e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999021e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999228e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999327e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999502e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999537e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999541e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999616e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999648e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999650e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999703e-01 0.000 0 0
Disease R-HSA-1643685 9.999721e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999750e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999760e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999801e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999839e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999875e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999886e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999908e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999971e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999971e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999977e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999979e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999980e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999986e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999986e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999990e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999991e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999995e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999998e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways