PKCI

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O15498 S174 PSP YKT6 HNTMEsLLERGEKLDDLVsKsEVLGTQSKAFYKTARKQNSC
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S137 Sugiyama EIF5B IF2 KIAA0741 EDKDsKSKKTAKPKVEMysGsDDDDDFNKLPKKAKGKAQKS
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 S214 Sugiyama EIF5B IF2 KIAA0741 LQsRKGQKKNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAE
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O95218 S153 Sugiyama ZRANB2 ZIS ZNF265 KYRGKAVGPAsILKEVEDKEsEGEEEDEDEDLsKyKLDEDE
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083 S27 iPTMNet|EPSD ANXA1 ANX1 LPC1 FLKQAWFIENEEQEyVQtVKssKGGPGsAVsPyPtFNPssD
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07900 S263 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P08047 S59 EPSD|PSP SP1 TSFP1 RssstGsssstGGGGQEsQPsPLALLAATCSRIESPNENSN
P08151 S243 EPSD|PSP GLI1 GLI REEKREPESVYETDCRWDGCsQEFDSQEQLVHHINSEHIHG
P08151 T304 EPSD|PSP GLI1 GLI AQYMLVVHMRRHTGEKPHKCtFEGCRKSYSRLENLKTHLRS
P08670 S34 SIGNOR|PSP VIM MFGGPGtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyA
P08670 S39 PSP VIM GtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyAssPGG
P08670 S56 PSP VIM RtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLRssVPG
P09651 S365 Sugiyama HNRNPA1 HNRPA1 GQyFAKPRNQGGyGGssssssyGsGRRF_____________
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P11142 S340 Sugiyama HSPA8 HSC70 HSP73 HSPA10 ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P15311 T567 SIGNOR|EPSD|PSP EZR VIL2 RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P15880 T202 Sugiyama RPS2 RPS4 CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17480 S412 PSP UBTF UBF UBF1 SKKPAQEGGKGGSEKPKRPVsAMFIFSEEKRRQLQEERPEL
P17844 S520 Sugiyama DDX5 G17P1 HELR HLR1 GKRGGFNTFRDRENYDRGYssLLKRDFGAKTQNGVYSAANY
P18615 S131 Sugiyama NELFE RD RDBP QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18615 Y133 Sugiyama NELFE RD RDBP sIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEA
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18621 T79 Sugiyama RPL17 PFRRYNGGVGRCAQAKQWGWtQGRWPKKSAEFLLHMLKNAE
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27448 T564 EPSD|PSP MARK3 CTAK1 EMK2 IssAAtPDRIRFPRGtASRstFHGQPRERRtAtYNGPPAsP
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29474 T495 SIGNOR NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P35579 S1714 Sugiyama MYH9 RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 S200 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 NyLGHtAKNAVItVPAyFNDsQRQAtKDAGQIsGLNVLRVI
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41743 S388 Sugiyama PRKCI DXS1179E YLHERGIIYRDLKLDNVLLDsEGHIKLTDYGMCKEGLRPGD
P41743 T142 Sugiyama PRKCI DXS1179E KSIYRRGARRWRKLyCANGHtFQAKRFNRRAHCAICTDRIW
P41743 T412 Sugiyama PRKCI DXS1179E IKLTDYGMCKEGLRPGDttstFCGtPNYIAPEILRGEDyGF
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776 S106 Sugiyama RPL27A tRVNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKA
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776 Y108 Sugiyama RPL27A VNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKAKF
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P49757 S276 PSP NUMB C14orf41 NNPHAIPRRHAPIEQLARQGsFRGFPALsQKMSPFKRQLsL
P49757 S295 PSP NUMB C14orf41 GsFRGFPALsQKMSPFKRQLsLRINELPstMQRKTDFPIKN
P49757 S7 PSP NUMB C14orf41 ______________MNKLRQsFRRKKDVyVPEASRPHQWQT
P50613 T170 EPSD|PSP CDK7 CAK CAK1 CDKN7 MO15 STK1 VLKLADFGLAKsFGsPNRAytHQVVtRWYRAPELLFGARMY
P50991 S51 Sugiyama CCT4 CCTD SRB AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P56270 S302 Sugiyama MAZ ZNF801 EMCGKAFRDVYHLNRHKLSHsDEKPyQCPVCQQRFKRKDRM
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P61254 S9 Sugiyama RPL26 ____________MKFNPFVtsDRsKNRKRHFNAPsHIRRKI
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61313 Y6 Sugiyama RPL15 EC45 TCBAP0781 _______________MGAYKyIQELWRKKQSDVMRFLLRVR
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62312 S74 Sugiyama LSM6 GQLKNKyGDAFIRGNNVLyIstQKRRM______________
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62753 T127 Sugiyama RPS6 OK/SW-cl.2 SVLNLVIVKKGEKDIPGLtDttVPRRLGPKRASRIRKLFNL
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104 T261 Sugiyama EEF1A1 EEF1A EF1A LENG7 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P78417 S23 Sugiyama GSTO1 GSTTLP28 GESARsLGKGsAPPGPVPEGsIRIySMRFCPFAERTRLVLK
P78545 S68 EPSD|PSP ELF3 ERT ESX JEN QMSLEGTEKASWLGEQPQFWsKTQVLDWISYQVEKNKYDAS
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S122 Sugiyama RPL19 LRRLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHI
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q05639 T261 Sugiyama EEF1A2 EEF1AL STN PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q09472 S89 PSP EP300 P300 GMVQDAASKHKQLSELLRsGssPNLNMGVGGPGQVMAsQAQ
Q13118 S384 PSP KLF10 TIEG TIEG1 SRIRSHICSHPGCGKTYFKSsHLKAHTRTHTGEKPFSCSWK
Q13118 T445 PSP KLF10 TIEG TIEG1 GEKKFACPMCDRRFMRSDHLtKHARRHLSAKKLPNWQMEVS
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13464 S1333 PSP ROCK1 VKKIPKNPPSGFVRAsPRTLstRStANQsFRKVVKNTSGKT
Q13464 S1341 PSP ROCK1 PSGFVRAsPRTLstRStANQsFRKVVKNTSGKTS_______
Q13464 T1024 PSP ROCK1 NKLAEIMNRKDFKIDRKKANtQDLRKKEKENRKLQLELNQE
Q13464 T1334 PSP ROCK1 KKIPKNPPSGFVRAsPRTLstRStANQsFRKVVKNTSGKTS
Q13464 T1337 PSP ROCK1 PKNPPSGFVRAsPRTLstRStANQsFRKVVKNTSGKTS___
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14119 S197 Sugiyama VEZF1 DB1 ZNF161 EMCGKAFRDVYHLNRHKLSHsDEKPFECPICNQRFKRKDRM
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14184 S34 PSP DOC2B DOC2BL IQEHMAIDVCPGPIRPIKQIsDYFPRFPRGLPPDAGPRAAA
Q14247 S261 EPSD|PSP CTTN EMS1 DRQDKCALGWDHQEKLQLHEsQKDyKTGFGGKFGVQsERQD
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15334 S659 SIGNOR LLGL1 DLG4 HUGL HUGL1 HPNDSLAMEGPLSRVKsLKKsLRQsFRRIRKsRVsGKKRAA
Q15910 S690 EPSD|PSP EZH2 KMT6 NNDFVVDATRKGNKIRFANHsVNPNCYAKVMMVNGDHRIGI
Q15910 T345 EPSD|PSP EZH2 KMT6 YQHLEGAKEFAAALTAERIKtPPKRPGGRRRGRLPNNssRP
Q15910 T487 EPSD|PSP EZH2 KMT6 YEFRVKEssIIAPAPAEDVDtPPRKKKRKHRLWAAHCRKIQ
Q16236 S40 PSP NFE2L2 NRF2 IDILWRQDIDLGVSREVFDFsQRRKEYELEKQKKLEKERQE
Q27J81 S1201 Sugiyama INF2 C14orf151 C14orf173 PEsALDtsLDKsFsEDAVtDssGsGtLPRARGRASKGTGKR
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q4VCS5 S538 EPSD|PSP AMOT KIAA1071 ANKQLAEKEYEGSEDTRKtIsQLFAKNKESQREKEKLEAEL
Q4VCS5 T536 EPSD|PSP AMOT KIAA1071 ETANKQLAEKEYEGSEDTRKtIsQLFAKNKESQREKEKLEA
Q4VCS5 T750 EPSD|PSP AMOT KIAA1071 EEEEILMANKRCLDMEGRIKtLHAQIIEKDAMIKVLQQRSR
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5VTE0 T261 Sugiyama EEF1A1P5 EEF1AL3 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6P1M3 S653 SIGNOR LLGL2 QLALEGPLSRVKSLKKSLRQsFRRMRRSRVSSRKRHPAGPP
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6STE5 S247 EPSD SMARCD3 BAF60C HRTPTTQETDGFQVKRPGDLsVRCTLLLMLDYQPPQFKLDP
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7KZI7 T596 EPSD|PSP MARK2 EMK1 sssGGAPDRTNFPRGVssRstFHAGQLRQVRDQQNLPyGVt
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8NAF0 S455 Sugiyama ZNF579 AGGPAPHPCPRCPRRFSRAYsLLRHQRCHRAELERAAALQA
Q8TAE6 T73 PSP PPP1R14C KEPI AAAAGQVQQQQQRRHQQGKVtVKYDRKELRKRLVLEEWIVE
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TEW0 S827 EPSD|PSP PARD3 PAR3 PAR3A sLsPDVDPVLAFQREGFGRQsMsEKRtKQFsDAsQLDFVKT
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q92934 S118 SIGNOR|EPSD|PSP BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S75 SIGNOR|EPSD|PSP BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 SIGNOR|EPSD|PSP BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q969H0 S10 EPSD|PSP FBXW7 FBW7 FBX30 SEL10 ___________MNQELLSVGsKRRRTGGsLRGNPSssQVDE
Q969H0 S18 SIGNOR|EPSD|PSP FBXW7 FBW7 FBX30 SEL10 ___MNQELLSVGsKRRRTGGsLRGNPSssQVDEEQMNRVVE
Q99613 S639 Sugiyama EIF3C EIF3S8 CAFRQGLTKDAHNALLDIQssGRAKELLGQGLLLRSLQERN
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BX40 S349 Sugiyama LSM14B C20orf40 FAM61B RAP55B SSRRTTWAEERKLNtEtFGVsGRFLRGRSSRGGFRGGRGNG
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9H8V3 T359 SIGNOR|EPSD|PSP ECT2 GSIQMDARAGETMYLYEKANtPELKKsVsMLsLNtPNsNRK
Q9NPB6 S345 SIGNOR|EPSD|PSP PARD6A PAR6A DQEQASSGWGSRIRGDGSGFsL___________________
Q9NYF8 S320 Sugiyama BCLAF1 BTF KIAA0164 sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UBS0 S473 ELM|EPSD|PSP RPS6KB2 STK14B PPPPSTTAPLPIRPPSGTKKsKRGRGRPGR___________
Q9UNX3 S9 Sugiyama RPL26L1 RPL26P1 ____________MKFNPFVtsDRsKNRKRHFNAPSHVRRKI
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 5.551115e-16 15.256 0 0
Signal Transduction R-HSA-162582 1.443290e-15 14.841 1 0
Cell Cycle, Mitotic R-HSA-69278 2.742251e-14 13.562 0 0
Cellular Senescence R-HSA-2559583 4.526379e-13 12.344 0 0
Apoptotic execution phase R-HSA-75153 4.931144e-11 10.307 0 0
Axon guidance R-HSA-422475 5.250641e-10 9.280 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.727509e-10 9.172 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.727509e-10 9.172 0 0
M Phase R-HSA-68886 9.906477e-10 9.004 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.710488e-09 8.767 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 9.163598e-09 8.038 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.080010e-08 7.967 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.625839e-08 7.581 0 0
Nervous system development R-HSA-9675108 2.677894e-08 7.572 0 0
Diseases of programmed cell death R-HSA-9645723 3.342281e-08 7.476 0 0
Meiotic synapsis R-HSA-1221632 4.433457e-08 7.353 0 0
DNA methylation R-HSA-5334118 4.694185e-08 7.328 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.430790e-08 7.265 0 0
Post NMDA receptor activation events R-HSA-438064 7.183587e-08 7.144 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.022373e-08 7.096 0 0
HDACs deacetylate histones R-HSA-3214815 8.758828e-08 7.058 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.370963e-07 6.863 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.481738e-07 6.829 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.299984e-07 6.638 0 0
Meiosis R-HSA-1500620 2.513482e-07 6.600 0 0
Packaging Of Telomere Ends R-HSA-171306 3.285662e-07 6.483 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.285662e-07 6.483 0 0
Cell Cycle Checkpoints R-HSA-69620 3.676217e-07 6.435 0 0
Defective pyroptosis R-HSA-9710421 5.972519e-07 6.224 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.071498e-07 6.150 0 0
Chromatin modifying enzymes R-HSA-3247509 7.101424e-07 6.149 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.303868e-07 6.136 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.297908e-07 6.081 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 8.941081e-07 6.049 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.080747e-06 5.966 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.093890e-06 5.961 0 0
NRAGE signals death through JNK R-HSA-193648 1.179650e-06 5.928 0 0
Mitotic Prophase R-HSA-68875 1.362537e-06 5.866 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.464865e-06 5.834 0 0
Chromatin organization R-HSA-4839726 1.452793e-06 5.838 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.492976e-06 5.826 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.695904e-06 5.771 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.705344e-06 5.768 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.388187e-06 5.622 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.356115e-06 5.628 0 0
Meiotic recombination R-HSA-912446 2.450841e-06 5.611 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.356115e-06 5.628 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.037108e-06 5.518 0 0
Apoptosis R-HSA-109581 3.497805e-06 5.456 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.500662e-06 5.456 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.746934e-06 5.426 0 0
Nucleosome assembly R-HSA-774815 3.746934e-06 5.426 0 0
Kinesins R-HSA-983189 3.638299e-06 5.439 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.638299e-06 5.439 0 0
HATs acetylate histones R-HSA-3214847 4.639549e-06 5.334 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.830165e-06 5.316 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.830165e-06 5.316 0 0
G alpha (12/13) signalling events R-HSA-416482 5.998216e-06 5.222 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.123881e-06 5.213 0 0
Cleavage of the damaged purine R-HSA-110331 6.794013e-06 5.168 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.841833e-06 5.106 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.234158e-06 5.084 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.537231e-06 5.069 0 0
Depurination R-HSA-73927 9.457319e-06 5.024 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.955717e-06 5.002 0 0
Cellular responses to stimuli R-HSA-8953897 1.015617e-05 4.993 1 0
Mitotic Prometaphase R-HSA-68877 1.156918e-05 4.937 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.382468e-05 4.859 0 0
Cellular responses to stress R-HSA-2262752 1.403179e-05 4.853 1 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.449642e-05 4.839 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.633080e-05 4.787 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.649284e-05 4.783 0 0
Programmed Cell Death R-HSA-5357801 1.767395e-05 4.753 0 0
Regulation of TP53 Activity R-HSA-5633007 2.110738e-05 4.676 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.195130e-05 4.659 0 0
ESR-mediated signaling R-HSA-8939211 2.321027e-05 4.634 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.481615e-05 4.605 1 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.726026e-05 4.564 0 0
L1CAM interactions R-HSA-373760 3.520079e-05 4.453 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.271174e-05 4.369 0 0
Depyrimidination R-HSA-73928 4.271174e-05 4.369 0 0
Signaling by Hippo R-HSA-2028269 4.589674e-05 4.338 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.875336e-05 4.312 0 0
Gene expression (Transcription) R-HSA-74160 4.832398e-05 4.316 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.198272e-05 4.284 0 0
DNA Double Strand Break Response R-HSA-5693606 5.282839e-05 4.277 0 0
RNA Polymerase II Transcription R-HSA-73857 5.424149e-05 4.266 0 0
Selective autophagy R-HSA-9663891 5.859126e-05 4.232 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.154116e-05 4.211 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.092661e-05 4.149 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.439769e-05 4.128 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.013233e-05 4.096 0 0
Signaling by VEGF R-HSA-194138 8.150755e-05 4.089 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 8.501709e-05 4.070 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.359563e-05 4.029 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.408779e-05 4.026 0 0
Rap1 signalling R-HSA-392517 1.080972e-04 3.966 0 0
Mitotic Anaphase R-HSA-68882 1.163886e-04 3.934 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.217827e-04 3.914 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.307417e-04 3.884 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.298185e-04 3.887 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.340588e-04 3.873 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.384587e-04 3.859 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.501038e-04 3.824 0 0
Generic Transcription Pathway R-HSA-212436 1.625151e-04 3.789 0 0
Reproduction R-HSA-1474165 1.925695e-04 3.715 0 0
RNA Polymerase I Transcription R-HSA-73864 2.014662e-04 3.696 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.205354e-04 3.657 1 1
Neuronal System R-HSA-112316 2.245745e-04 3.649 0 0
Separation of Sister Chromatids R-HSA-2467813 2.405354e-04 3.619 0 0
FOXO-mediated transcription R-HSA-9614085 2.514338e-04 3.600 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.574070e-04 3.589 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.998081e-04 3.523 0 0
EPH-Ephrin signaling R-HSA-2682334 3.065822e-04 3.513 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.254242e-04 3.488 0 0
Interleukin-12 signaling R-HSA-9020591 3.144411e-04 3.502 0 0
Semaphorin interactions R-HSA-373755 3.274613e-04 3.485 0 0
G2/M Transition R-HSA-69275 3.347256e-04 3.475 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.716682e-04 3.430 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.716682e-04 3.430 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.755018e-04 3.425 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.093443e-04 3.388 0 0
Recycling pathway of L1 R-HSA-437239 4.070721e-04 3.390 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.853773e-04 3.414 0 0
Base Excision Repair R-HSA-73884 3.974810e-04 3.401 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.678899e-04 3.330 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.754618e-04 3.323 0 0
Gene Silencing by RNA R-HSA-211000 4.796165e-04 3.319 0 0
mRNA 3'-end processing R-HSA-72187 4.825365e-04 3.316 0 0
mRNA Splicing R-HSA-72172 4.903721e-04 3.309 0 0
Cell-Cell communication R-HSA-1500931 5.256017e-04 3.279 1 0
Interleukin-37 signaling R-HSA-9008059 5.393742e-04 3.268 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.668422e-04 3.247 0 0
Chromosome Maintenance R-HSA-73886 5.925124e-04 3.227 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.936001e-04 3.227 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.271467e-04 3.203 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.685647e-04 3.175 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.694794e-04 3.174 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.820525e-04 3.166 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.849469e-04 3.164 0 0
Deubiquitination R-HSA-5688426 6.996498e-04 3.155 0 0
Ub-specific processing proteases R-HSA-5689880 7.451676e-04 3.128 0 0
Homology Directed Repair R-HSA-5693538 7.576495e-04 3.121 0 0
G2/M Checkpoints R-HSA-69481 7.748883e-04 3.111 0 0
Death Receptor Signaling R-HSA-73887 7.751670e-04 3.111 1 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.660178e-04 3.062 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.583744e-04 3.066 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.673949e-04 3.062 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.807229e-04 3.055 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.072296e-04 3.042 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 9.143055e-04 3.039 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.720665e-04 3.012 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 9.878169e-04 3.005 0 0
MAPK family signaling cascades R-HSA-5683057 1.067173e-03 2.972 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.081502e-03 2.966 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.088529e-03 2.963 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.182299e-03 2.927 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.168404e-03 2.932 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.175268e-03 2.930 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.088529e-03 2.963 0 0
Membrane Trafficking R-HSA-199991 1.183278e-03 2.927 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.186476e-03 2.926 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.186476e-03 2.926 0 0
Signaling by Interleukins R-HSA-449147 1.191491e-03 2.924 0 0
Signaling by NOTCH R-HSA-157118 1.218203e-03 2.914 1 0
TCF dependent signaling in response to WNT R-HSA-201681 1.224858e-03 2.912 0 0
DNA Repair R-HSA-73894 1.228347e-03 2.911 0 0
Cell junction organization R-HSA-446728 1.250858e-03 2.903 1 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.355399e-03 2.868 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.397916e-03 2.855 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.413102e-03 2.850 0 0
Telomere Maintenance R-HSA-157579 1.510448e-03 2.821 0 0
G-protein mediated events R-HSA-112040 1.521620e-03 2.818 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.417555e-03 2.848 0 0
FLT3 Signaling R-HSA-9607240 1.397916e-03 2.855 0 0
HCMV Early Events R-HSA-9609690 1.562793e-03 2.806 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.568073e-03 2.805 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.667819e-03 2.778 0 0
RAF activation R-HSA-5673000 1.909726e-03 2.719 0 0
Signaling by RAS mutants R-HSA-6802949 1.976641e-03 2.704 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.976641e-03 2.704 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.976641e-03 2.704 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.976641e-03 2.704 0 0
Interleukin-12 family signaling R-HSA-447115 2.126572e-03 2.672 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.131859e-03 2.671 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.131859e-03 2.671 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.263807e-03 2.645 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.286560e-03 2.641 0 0
Activation of RAC1 R-HSA-428540 2.390089e-03 2.622 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.443883e-03 2.612 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.696656e-03 2.569 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.570160e-03 2.590 0 0
Neurodegenerative Diseases R-HSA-8863678 2.570160e-03 2.590 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.570160e-03 2.590 0 0
Aggrephagy R-HSA-9646399 2.783924e-03 2.555 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.802730e-03 2.552 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.802730e-03 2.552 0 0
RET signaling R-HSA-8853659 2.967652e-03 2.528 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.967652e-03 2.528 0 0
Calmodulin induced events R-HSA-111933 2.967652e-03 2.528 0 0
CaM pathway R-HSA-111997 2.967652e-03 2.528 0 0
Transmission across Chemical Synapses R-HSA-112315 3.049994e-03 2.516 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.074445e-03 2.512 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.130811e-03 2.504 0 0
Netrin-1 signaling R-HSA-373752 3.140247e-03 2.503 0 0
Polo-like kinase mediated events R-HSA-156711 3.183857e-03 2.497 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.183857e-03 2.497 0 0
Long-term potentiation R-HSA-9620244 3.329300e-03 2.478 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.399293e-03 2.469 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.559144e-03 2.449 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.559144e-03 2.449 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.559144e-03 2.449 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.277639e-03 2.484 0 0
Signaling by ALK in cancer R-HSA-9700206 3.277639e-03 2.484 0 0
Developmental Biology R-HSA-1266738 3.481404e-03 2.458 0 0
Co-inhibition by PD-1 R-HSA-389948 3.595792e-03 2.444 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.648326e-03 2.438 0 0
Opioid Signalling R-HSA-111885 3.698210e-03 2.432 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.019582e-03 2.396 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.042501e-03 2.393 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.154060e-03 2.382 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.164610e-03 2.380 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.164610e-03 2.380 0 0
Metalloprotease DUBs R-HSA-5689901 4.259950e-03 2.371 0 0
Macroautophagy R-HSA-1632852 4.592503e-03 2.338 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.650228e-03 2.333 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.650228e-03 2.333 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.677294e-03 2.330 0 0
Ca-dependent events R-HSA-111996 4.967140e-03 2.304 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.016027e-03 2.300 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.120502e-03 2.291 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.210852e-03 2.283 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.319170e-03 2.274 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.420023e-03 2.266 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.572806e-03 2.254 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.572806e-03 2.254 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.623244e-03 2.250 0 0
Oncogene Induced Senescence R-HSA-2559585 5.879248e-03 2.231 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.328357e-03 2.199 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.051365e-03 2.218 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.256367e-03 2.204 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.461216e-03 2.190 1 0
Signaling by Nuclear Receptors R-HSA-9006931 6.471914e-03 2.189 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.767445e-03 2.170 0 0
Amyloid fiber formation R-HSA-977225 5.944177e-03 2.226 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.785838e-03 2.168 0 0
RMTs methylate histone arginines R-HSA-3214858 7.078625e-03 2.150 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.267221e-03 2.139 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.306945e-03 2.136 0 0
Autophagy R-HSA-9612973 7.601853e-03 2.119 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.633436e-03 2.117 0 0
MHC class II antigen presentation R-HSA-2132295 7.644409e-03 2.117 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.817901e-03 2.107 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 8.035910e-03 2.095 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.035910e-03 2.095 0 0
DAG and IP3 signaling R-HSA-1489509 8.376470e-03 2.077 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.390761e-03 2.076 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.601861e-03 2.065 0 0
Adaptive Immune System R-HSA-1280218 8.659786e-03 2.062 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.762215e-03 2.057 0 0
Signaling by RAF1 mutants R-HSA-9656223 9.299027e-03 2.032 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.323335e-03 2.030 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 9.497626e-03 2.022 0 0
Ephrin signaling R-HSA-3928664 9.547356e-03 2.020 0 0
Cell-cell junction organization R-HSA-421270 1.000293e-02 2.000 1 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.018093e-02 1.992 0 0
Activation of BH3-only proteins R-HSA-114452 1.024437e-02 1.990 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.032013e-02 1.986 0 0
Adherens junctions interactions R-HSA-418990 1.036048e-02 1.985 0 0
PLC beta mediated events R-HSA-112043 1.085057e-02 1.965 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.087783e-02 1.963 0 0
TRP channels R-HSA-3295583 1.104436e-02 1.957 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.104436e-02 1.957 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.115528e-02 1.953 0 0
Signaling by WNT R-HSA-195721 1.119879e-02 1.951 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.387698e-02 1.858 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.387698e-02 1.858 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.387698e-02 1.858 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.387698e-02 1.858 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.387698e-02 1.858 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.212316e-02 1.916 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.295454e-02 1.888 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.306039e-02 1.884 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.399333e-02 1.854 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.510286e-02 1.821 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.542896e-02 1.812 0 0
Gap junction trafficking and regulation R-HSA-157858 1.557140e-02 1.808 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.603803e-02 1.795 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.632639e-02 1.787 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.632639e-02 1.787 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.755982e-02 1.755 0 0
Integrin signaling R-HSA-354192 1.794918e-02 1.746 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.794918e-02 1.746 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.819592e-02 1.740 0 0
Signaling by ERBB2 R-HSA-1227986 1.829788e-02 1.738 0 0
MAP2K and MAPK activation R-HSA-5674135 1.978968e-02 1.704 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.045656e-02 1.689 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.065488e-02 1.685 0 0
Signaling by EGFR R-HSA-177929 2.075872e-02 1.683 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.075872e-02 1.683 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.075872e-02 1.683 0 0
Muscle contraction R-HSA-397014 2.168357e-02 1.664 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.347419e-02 1.629 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.358813e-02 1.627 0 0
Signaling by ROBO receptors R-HSA-376176 2.362349e-02 1.627 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.367977e-02 1.626 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.745970e-02 1.561 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.842527e-02 1.546 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.842527e-02 1.546 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.763717e-02 1.559 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.378707e-02 1.624 0 0
Trafficking of AMPA receptors R-HSA-399719 2.819283e-02 1.550 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.564394e-02 1.591 0 0
Cellular response to heat stress R-HSA-3371556 2.746151e-02 1.561 0 0
Mitophagy R-HSA-5205647 2.508677e-02 1.601 0 0
Adrenoceptors R-HSA-390696 2.745970e-02 1.561 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.763717e-02 1.559 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.544485e-02 1.594 0 0
GPER1 signaling R-HSA-9634597 2.676628e-02 1.572 0 0
HCMV Infection R-HSA-9609646 2.725094e-02 1.565 0 0
Co-stimulation by CD28 R-HSA-389356 2.676628e-02 1.572 0 0
Gap junction assembly R-HSA-190861 2.508677e-02 1.601 0 0
Metabolism of RNA R-HSA-8953854 2.642757e-02 1.578 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.763717e-02 1.559 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.608677e-02 1.584 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.404190e-02 1.619 0 0
Sensory processing of sound R-HSA-9659379 2.793608e-02 1.554 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.931217e-02 1.533 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.940437e-02 1.532 1 1
Cardiac conduction R-HSA-5576891 2.982177e-02 1.525 0 0
Gap junction trafficking R-HSA-190828 3.042367e-02 1.517 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.051628e-02 1.515 0 0
PKR-mediated signaling R-HSA-9833482 3.096518e-02 1.509 0 0
Centrosome maturation R-HSA-380287 3.177453e-02 1.498 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.383161e-02 1.471 0 0
DNA Replication R-HSA-69306 3.392186e-02 1.470 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.475354e-02 1.459 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.475354e-02 1.459 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.475354e-02 1.459 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.475354e-02 1.459 0 0
Signaling by NOTCH1 R-HSA-1980143 3.522182e-02 1.453 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.701992e-02 1.432 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.701992e-02 1.432 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.701992e-02 1.432 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.701992e-02 1.432 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.701992e-02 1.432 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.701992e-02 1.432 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.701992e-02 1.432 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.757889e-02 1.425 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.757889e-02 1.425 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.757889e-02 1.425 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.757889e-02 1.425 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.757889e-02 1.425 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.757889e-02 1.425 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.762907e-02 1.424 0 0
Immune System R-HSA-168256 3.775300e-02 1.423 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.870701e-02 1.412 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.870701e-02 1.412 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.870701e-02 1.412 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.870701e-02 1.412 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.930347e-02 1.406 0 0
Voltage gated Potassium channels R-HSA-1296072 3.939162e-02 1.405 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.009826e-02 1.397 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.070191e-02 1.390 0 0
Potassium Channels R-HSA-1296071 4.080879e-02 1.389 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.145687e-02 1.382 0 0
DARPP-32 events R-HSA-180024 4.392745e-02 1.357 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.406656e-02 1.356 0 0
Hemostasis R-HSA-109582 4.454458e-02 1.351 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.487417e-02 1.348 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.487417e-02 1.348 0 0
MTOR signalling R-HSA-165159 4.513672e-02 1.345 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.701505e-02 1.328 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.701505e-02 1.328 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.711794e-02 1.327 0 0
Stimuli-sensing channels R-HSA-2672351 4.825832e-02 1.316 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.960901e-02 1.304 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.982878e-02 1.303 0 0
Regulation of CDH11 function R-HSA-9762292 4.982878e-02 1.303 0 0
HDMs demethylate histones R-HSA-3214842 4.983542e-02 1.302 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.983542e-02 1.302 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.389685e-02 1.195 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.115882e-02 1.291 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.162957e-02 1.287 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.862258e-02 1.232 0 0
Signal amplification R-HSA-392518 5.168191e-02 1.287 0 0
Nuclear import of Rev protein R-HSA-180746 5.168191e-02 1.287 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.389685e-02 1.195 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.862258e-02 1.232 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.953151e-02 1.225 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.953151e-02 1.225 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.953151e-02 1.225 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.953151e-02 1.225 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.389685e-02 1.195 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.118769e-02 1.213 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.953151e-02 1.225 0 0
Signaling by ALK R-HSA-201556 5.162957e-02 1.287 0 0
Signaling by APC mutants R-HSA-4839744 6.409400e-02 1.193 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.409400e-02 1.193 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.409400e-02 1.193 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.409400e-02 1.193 0 0
Interleukin-2 signaling R-HSA-9020558 6.409400e-02 1.193 0 0
Regulation of gap junction activity R-HSA-191650 6.427568e-02 1.192 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 6.427568e-02 1.192 0 0
TNFR1-mediated ceramide production R-HSA-5626978 6.427568e-02 1.192 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 6.427568e-02 1.192 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 6.427568e-02 1.192 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.481096e-02 1.188 0 0
PI Metabolism R-HSA-1483255 6.636805e-02 1.178 0 0
Notch-HLH transcription pathway R-HSA-350054 6.662134e-02 1.176 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.662134e-02 1.176 0 0
mTORC1-mediated signalling R-HSA-166208 6.662134e-02 1.176 0 0
Interleukin-1 family signaling R-HSA-446652 6.697945e-02 1.174 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.707150e-02 1.173 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.743264e-02 1.171 0 0
Netrin mediated repulsion signals R-HSA-418886 6.743264e-02 1.171 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.743264e-02 1.171 0 0
SOS-mediated signalling R-HSA-112412 6.743264e-02 1.171 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.743264e-02 1.171 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.777944e-02 1.169 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.777944e-02 1.169 0 0
Ion homeostasis R-HSA-5578775 6.808113e-02 1.167 0 0
HSF1-dependent transactivation R-HSA-3371571 7.032150e-02 1.153 0 0
Rab regulation of trafficking R-HSA-9007101 7.176103e-02 1.144 0 0
p75NTR signals via NF-kB R-HSA-193639 7.198555e-02 1.143 1 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.198555e-02 1.143 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.198555e-02 1.143 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 7.198555e-02 1.143 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.198555e-02 1.143 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.327364e-02 1.135 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.328365e-02 1.135 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.519541e-02 1.124 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.605768e-02 1.119 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.642200e-02 1.117 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 7.668676e-02 1.115 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 7.668676e-02 1.115 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 7.668676e-02 1.115 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 7.668676e-02 1.115 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 7.668676e-02 1.115 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 7.668676e-02 1.115 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 7.668676e-02 1.115 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.693529e-02 1.114 0 0
Neurexins and neuroligins R-HSA-6794361 7.797538e-02 1.108 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.809309e-02 1.107 0 0
Pyroptosis R-HSA-5620971 7.809309e-02 1.107 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.947375e-02 1.100 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.041201e-02 1.095 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.041201e-02 1.095 0 0
Signaling by AXIN mutants R-HSA-4839735 8.041201e-02 1.095 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 9.166855e-02 1.038 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 9.166855e-02 1.038 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 9.166855e-02 1.038 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 8.811630e-02 1.055 0 0
Activation of RAS in B cells R-HSA-1169092 8.811630e-02 1.055 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.811630e-02 1.055 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.811630e-02 1.055 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.114729e-01 0.953 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.114729e-01 0.953 0 0
ALK mutants bind TKIs R-HSA-9700645 1.114729e-01 0.953 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.872607e-02 1.006 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.676963e-02 1.062 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.948047e-02 1.048 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.931116e-02 1.049 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.014311e-01 0.994 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.886464e-02 1.005 0 0
Translation initiation complex formation R-HSA-72649 9.484157e-02 1.023 0 0
IGF1R signaling cascade R-HSA-2428924 8.716569e-02 1.060 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.103677e-01 0.957 0 0
Cyclin D associated events in G1 R-HSA-69231 1.028367e-01 0.988 0 0
G1 Phase R-HSA-69236 1.028367e-01 0.988 0 0
Formation of definitive endoderm R-HSA-9823730 8.948047e-02 1.048 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.517563e-02 1.021 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.024720e-01 0.989 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.041487e-01 0.982 0 0
S Phase R-HSA-69242 1.042372e-01 0.982 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.114729e-01 0.953 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 9.166855e-02 1.038 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 9.166855e-02 1.038 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 9.872607e-02 1.006 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.676963e-02 1.062 0 0
Hedgehog 'off' state R-HSA-5610787 8.664367e-02 1.062 0 0
Signaling by LTK R-HSA-9842663 9.872607e-02 1.006 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.567233e-02 1.067 0 0
Interferon Signaling R-HSA-913531 9.332516e-02 1.030 0 0
Protein ubiquitination R-HSA-8852135 8.698152e-02 1.061 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.030877e-01 0.987 0 0
Signalling to ERKs R-HSA-187687 1.107640e-01 0.956 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.945992e-02 1.048 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.600210e-02 1.065 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 9.166855e-02 1.038 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.811630e-02 1.055 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.591041e-02 1.018 0 0
TBC/RABGAPs R-HSA-8854214 9.273866e-02 1.033 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.698152e-02 1.061 0 0
Signaling by NTRKs R-HSA-166520 1.042372e-01 0.982 0 0
Glycolysis R-HSA-70171 8.664367e-02 1.062 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.483099e-02 1.023 0 0
NrCAM interactions R-HSA-447038 9.166855e-02 1.038 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.135628e-01 0.945 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.138001e-01 0.944 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.144425e-01 0.941 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.144425e-01 0.941 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.181447e-01 0.928 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.189406e-01 0.925 0 0
Formation of axial mesoderm R-HSA-9796292 1.189406e-01 0.925 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.189406e-01 0.925 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.189406e-01 0.925 0 0
HCMV Late Events R-HSA-9610379 1.227182e-01 0.911 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.230171e-01 0.910 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.230171e-01 0.910 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.230171e-01 0.910 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.230171e-01 0.910 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.230171e-01 0.910 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.238029e-01 0.907 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.238152e-01 0.907 0 0
Regulation of TP53 Expression R-HSA-6804754 1.238152e-01 0.907 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.238152e-01 0.907 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.238152e-01 0.907 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.238152e-01 0.907 0 0
Diseases of cellular response to stress R-HSA-9675132 1.238152e-01 0.907 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.238152e-01 0.907 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.238152e-01 0.907 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.238152e-01 0.907 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.238152e-01 0.907 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.238152e-01 0.907 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.238152e-01 0.907 0 0
Potassium transport channels R-HSA-1296067 1.238152e-01 0.907 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.238152e-01 0.907 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.238152e-01 0.907 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.238152e-01 0.907 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.238152e-01 0.907 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.249103e-01 0.903 0 0
Signaling by TGFBR3 R-HSA-9839373 1.249103e-01 0.903 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.281684e-01 0.892 0 0
Signaling by PTK6 R-HSA-8848021 1.281684e-01 0.892 0 0
G0 and Early G1 R-HSA-1538133 1.283272e-01 0.892 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.283734e-01 0.892 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.295294e-01 0.888 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.307979e-01 0.883 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.316786e-01 0.880 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.329757e-01 0.876 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.329757e-01 0.876 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.329757e-01 0.876 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.329757e-01 0.876 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.348327e-01 0.870 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.368687e-01 0.864 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.368687e-01 0.864 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.370801e-01 0.863 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.372546e-01 0.862 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.372546e-01 0.862 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.372546e-01 0.862 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.372546e-01 0.862 0 0
Signaling by Leptin R-HSA-2586552 1.372546e-01 0.862 0 0
PKA activation in glucagon signalling R-HSA-164378 1.400890e-01 0.854 0 0
PKA activation R-HSA-163615 1.400890e-01 0.854 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.400890e-01 0.854 0 0
Platelet sensitization by LDL R-HSA-432142 1.400890e-01 0.854 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.405539e-01 0.852 0 0
KIT mutants bind TKIs R-HSA-9669921 1.405539e-01 0.852 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.405539e-01 0.852 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.405539e-01 0.852 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.405539e-01 0.852 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.405539e-01 0.852 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.405539e-01 0.852 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.405539e-01 0.852 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.405539e-01 0.852 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.405539e-01 0.852 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.405539e-01 0.852 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.405539e-01 0.852 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.405539e-01 0.852 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.405539e-01 0.852 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.405539e-01 0.852 0 0
Regulation of KIT signaling R-HSA-1433559 1.409269e-01 0.851 0 0
Signal regulatory protein family interactions R-HSA-391160 1.409269e-01 0.851 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.419068e-01 0.848 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.430596e-01 0.844 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.430596e-01 0.844 0 0
Cardiogenesis R-HSA-9733709 1.430596e-01 0.844 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.430596e-01 0.844 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.759388e-01 0.755 0 0
Axonal growth stimulation R-HSA-209563 1.759388e-01 0.755 0 0
MET activates PTPN11 R-HSA-8865999 1.759388e-01 0.755 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.759388e-01 0.755 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.576295e-01 0.802 0 0
CREB phosphorylation R-HSA-199920 1.576295e-01 0.802 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.576295e-01 0.802 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.947951e-01 0.710 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.947951e-01 0.710 0 0
Disinhibition of SNARE formation R-HSA-114516 1.947951e-01 0.710 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.947951e-01 0.710 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.651709e-01 0.782 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.949038e-01 0.710 0 0
NF-kB is activated and signals survival R-HSA-209560 1.949038e-01 0.710 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.949038e-01 0.710 0 0
DCC mediated attractive signaling R-HSA-418885 1.645297e-01 0.784 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.645297e-01 0.784 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.645297e-01 0.784 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.606045e-01 0.794 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.895729e-01 0.722 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.895729e-01 0.722 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.823242e-01 0.739 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.823242e-01 0.739 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.823242e-01 0.739 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.823242e-01 0.739 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.492542e-01 0.826 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.744347e-01 0.758 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.051277e-01 0.688 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.051277e-01 0.688 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.051277e-01 0.688 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.664461e-01 0.779 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.586072e-01 0.800 0 0
Striated Muscle Contraction R-HSA-390522 1.586072e-01 0.800 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.844962e-01 0.734 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.844962e-01 0.734 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.437824e-01 0.842 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.156133e-01 0.666 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.919863e-01 0.717 0 0
G alpha (z) signalling events R-HSA-418597 1.667362e-01 0.778 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.540901e-01 0.812 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.909295e-01 0.719 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.015274e-01 0.696 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.915172e-01 0.718 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.915172e-01 0.718 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.782280e-01 0.749 0 0
Protein folding R-HSA-391251 1.506025e-01 0.822 0 0
Signaling by FGFR3 R-HSA-5654741 1.865291e-01 0.729 0 0
Signaling by FGFR4 R-HSA-5654743 1.574156e-01 0.803 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.489467e-01 0.827 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.017833e-01 0.695 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.510350e-01 0.821 0 0
Specification of the neural plate border R-HSA-9834899 1.606045e-01 0.794 0 0
Myogenesis R-HSA-525793 2.156133e-01 0.666 0 0
Signaling by SCF-KIT R-HSA-1433557 1.574156e-01 0.803 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.949038e-01 0.710 0 0
Signalling to RAS R-HSA-167044 2.051277e-01 0.688 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.976440e-01 0.704 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.960036e-01 0.708 0 0
TGFBR3 expression R-HSA-9839394 1.945892e-01 0.711 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.097231e-01 0.678 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.947951e-01 0.710 0 0
p38MAPK events R-HSA-171007 1.645297e-01 0.784 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.606045e-01 0.794 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.884474e-01 0.725 0 0
Platelet calcium homeostasis R-HSA-418360 1.664461e-01 0.779 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.540901e-01 0.812 0 0
PTEN Regulation R-HSA-6807070 2.080571e-01 0.682 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.919863e-01 0.717 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.156133e-01 0.666 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.759388e-01 0.755 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.540901e-01 0.812 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.844962e-01 0.734 0 0
Vesicle-mediated transport R-HSA-5653656 2.050876e-01 0.688 0 0
Signaling by Hedgehog R-HSA-5358351 1.489776e-01 0.827 0 0
Cilium Assembly R-HSA-5617833 1.481706e-01 0.829 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.664461e-01 0.779 0 0
Ion channel transport R-HSA-983712 1.834239e-01 0.737 0 0
Regulation of PTEN localization R-HSA-8948747 1.947951e-01 0.710 0 0
Intraflagellar transport R-HSA-5620924 1.494256e-01 0.826 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 1.814574e-01 0.741 0 0
Diseases of Immune System R-HSA-5260271 1.814574e-01 0.741 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.814574e-01 0.741 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.437824e-01 0.842 0 0
UCH proteinases R-HSA-5689603 2.119108e-01 0.674 0 0
The NLRP3 inflammasome R-HSA-844456 1.606045e-01 0.794 0 0
Downstream signal transduction R-HSA-186763 2.033421e-01 0.692 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.586072e-01 0.800 0 0
RAB geranylgeranylation R-HSA-8873719 1.578802e-01 0.802 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.109530e-01 0.676 0 0
Glucose metabolism R-HSA-70326 2.011961e-01 0.696 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.158659e-01 0.666 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.214652e-01 0.655 0 0
Metabolism of non-coding RNA R-HSA-194441 2.222961e-01 0.653 0 0
snRNP Assembly R-HSA-191859 2.222961e-01 0.653 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.229157e-01 0.652 0 0
Signaling by WNT in cancer R-HSA-4791275 2.229157e-01 0.652 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.240011e-01 0.650 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.243488e-01 0.649 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.243488e-01 0.649 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.243488e-01 0.649 0 0
Peptide chain elongation R-HSA-156902 2.250245e-01 0.648 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.261217e-01 0.646 1 1
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.261217e-01 0.646 0 0
Repression of WNT target genes R-HSA-4641265 2.261217e-01 0.646 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.261217e-01 0.646 0 0
Regulation of IFNG signaling R-HSA-877312 2.261217e-01 0.646 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.261217e-01 0.646 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.613593e-01 0.583 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.613593e-01 0.583 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.613593e-01 0.583 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.613593e-01 0.583 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.613593e-01 0.583 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.613593e-01 0.583 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.613593e-01 0.583 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.613593e-01 0.583 0 0
NADE modulates death signalling R-HSA-205025 2.307237e-01 0.637 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.307237e-01 0.637 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.307237e-01 0.637 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.307237e-01 0.637 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.307237e-01 0.637 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.307237e-01 0.637 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.651901e-01 0.437 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.651901e-01 0.437 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.651901e-01 0.437 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.651901e-01 0.437 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.651901e-01 0.437 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.651901e-01 0.437 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.651901e-01 0.437 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.651901e-01 0.437 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 3.651901e-01 0.437 0 0
Intestinal infectious diseases R-HSA-8942233 3.651901e-01 0.437 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.651901e-01 0.437 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.651901e-01 0.437 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.651901e-01 0.437 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.651901e-01 0.437 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.651901e-01 0.437 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.651901e-01 0.437 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.651901e-01 0.437 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.651901e-01 0.437 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.651901e-01 0.437 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.651901e-01 0.437 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.863930e-01 0.543 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.863930e-01 0.543 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.863930e-01 0.543 0 0
IRS activation R-HSA-74713 2.863930e-01 0.543 0 0
Activation of AKT2 R-HSA-165158 2.863930e-01 0.543 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.863930e-01 0.543 0 0
G2 Phase R-HSA-68911 2.863930e-01 0.543 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.863930e-01 0.543 0 0
Type I hemidesmosome assembly R-HSA-446107 2.338225e-01 0.631 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.338225e-01 0.631 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 2.338225e-01 0.631 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.338225e-01 0.631 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.740646e-01 0.562 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 2.740646e-01 0.562 0 0
Lipophagy R-HSA-9613354 2.740646e-01 0.562 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.740646e-01 0.562 0 0
WNT mediated activation of DVL R-HSA-201688 2.740646e-01 0.562 0 0
Gap junction degradation R-HSA-190873 2.740646e-01 0.562 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.416162e-01 0.466 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.416162e-01 0.466 0 0
Phosphorylation of Emi1 R-HSA-176417 3.416162e-01 0.466 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.416162e-01 0.466 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.416162e-01 0.466 0 0
PDE3B signalling R-HSA-165160 3.416162e-01 0.466 0 0
PKB-mediated events R-HSA-109703 3.416162e-01 0.466 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.416162e-01 0.466 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.416162e-01 0.466 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.544305e-01 0.343 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 4.544305e-01 0.343 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.544305e-01 0.343 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.544305e-01 0.343 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.544305e-01 0.343 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.544305e-01 0.343 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.544305e-01 0.343 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.544305e-01 0.343 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.544305e-01 0.343 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.584911e-01 0.588 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.149333e-01 0.502 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.149333e-01 0.502 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.149333e-01 0.502 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.149333e-01 0.502 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.149333e-01 0.502 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.288855e-01 0.640 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.288855e-01 0.640 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.916858e-01 0.535 0 0
STAT5 Activation R-HSA-9645135 3.954193e-01 0.403 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 3.954193e-01 0.403 0 0
GAB1 signalosome R-HSA-180292 2.713995e-01 0.566 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.713995e-01 0.566 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.559083e-01 0.449 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.559083e-01 0.449 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.253943e-01 0.488 0 0
Erythropoietin activates RAS R-HSA-9027284 3.253943e-01 0.488 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.253943e-01 0.488 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.253943e-01 0.488 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.253943e-01 0.488 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.787163e-01 0.555 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.639497e-01 0.578 0 0
Signaling by Erythropoietin R-HSA-9006335 2.829315e-01 0.548 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.829315e-01 0.548 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.829315e-01 0.548 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.045090e-01 0.516 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.045090e-01 0.516 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.045090e-01 0.516 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.295132e-01 0.482 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.593249e-01 0.445 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.965397e-01 0.402 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.965397e-01 0.402 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.965397e-01 0.402 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.471106e-01 0.350 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.471106e-01 0.350 0 0
CHL1 interactions R-HSA-447041 4.471106e-01 0.350 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 4.471106e-01 0.350 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.471106e-01 0.350 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.471106e-01 0.350 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.471106e-01 0.350 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.471106e-01 0.350 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.471106e-01 0.350 0 0
Tight junction interactions R-HSA-420029 3.306998e-01 0.481 1 1
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.306998e-01 0.481 0 0
Lagging Strand Synthesis R-HSA-69186 3.590471e-01 0.445 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.069754e-01 0.513 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.069754e-01 0.513 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.932101e-01 0.405 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.932101e-01 0.405 0 0
Phase 2 - plateau phase R-HSA-5576893 3.932101e-01 0.405 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.685693e-01 0.571 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.526446e-01 0.597 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.364474e-01 0.360 0 0
Polymerase switching R-HSA-69091 4.364474e-01 0.360 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.364474e-01 0.360 0 0
Leading Strand Synthesis R-HSA-69109 4.364474e-01 0.360 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.290320e-01 0.483 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.886546e-01 0.410 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.886546e-01 0.410 0 0
IRS-mediated signalling R-HSA-112399 2.854834e-01 0.544 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.544568e-01 0.450 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.249806e-01 0.488 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.837339e-01 0.416 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.837339e-01 0.416 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.268087e-01 0.370 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.268087e-01 0.370 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.268087e-01 0.370 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 4.181668e-01 0.379 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.103193e-01 0.387 0 0
PI3K Cascade R-HSA-109704 3.842143e-01 0.415 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.367899e-01 0.360 0 0
Signaling by NOTCH4 R-HSA-9013694 3.633010e-01 0.440 0 0
Signaling by FGFR2 R-HSA-5654738 3.586093e-01 0.445 0 0
Attenuation phase R-HSA-3371568 4.189980e-01 0.378 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.497281e-01 0.456 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.552708e-01 0.449 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.324602e-01 0.364 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.441356e-01 0.352 0 0
Neutrophil degranulation R-HSA-6798695 2.675073e-01 0.573 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.244381e-01 0.372 0 0
RNA Polymerase III Transcription R-HSA-74158 3.290320e-01 0.483 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.590471e-01 0.445 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.590471e-01 0.445 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.590471e-01 0.445 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.713995e-01 0.566 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.571521e-01 0.447 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.432093e-01 0.614 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.432093e-01 0.614 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.552430e-01 0.593 0 0
DAP12 signaling R-HSA-2424491 3.064449e-01 0.514 0 0
Adipogenesis R-HSA-9843745 2.396809e-01 0.620 0 0
G1/S Transition R-HSA-69206 3.762765e-01 0.424 0 0
G-protein beta:gamma signalling R-HSA-397795 2.431438e-01 0.614 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.027290e-01 0.395 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.031041e-01 0.395 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.189980e-01 0.378 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.189980e-01 0.378 0 0
Insulin receptor signalling cascade R-HSA-74751 3.007196e-01 0.522 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.744950e-01 0.561 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.552430e-01 0.593 0 0
Signaling by FGFR1 R-HSA-5654736 2.686768e-01 0.571 0 0
GPCR downstream signalling R-HSA-388396 4.173896e-01 0.379 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.932101e-01 0.405 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.382309e-01 0.623 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.271837e-01 0.485 0 0
Activation of GABAB receptors R-HSA-991365 3.480063e-01 0.458 0 0
Signal attenuation R-HSA-74749 3.149333e-01 0.502 0 0
Integration of provirus R-HSA-162592 3.965397e-01 0.402 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.932101e-01 0.405 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.237159e-01 0.490 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.686768e-01 0.571 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.382309e-01 0.623 0 0
GPVI-mediated activation cascade R-HSA-114604 3.290320e-01 0.483 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.431438e-01 0.614 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.965397e-01 0.402 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.526707e-01 0.597 0 0
Interleukin-15 signaling R-HSA-8983432 4.364474e-01 0.360 0 0
G alpha (s) signalling events R-HSA-418555 3.631099e-01 0.440 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.643222e-01 0.439 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.643222e-01 0.439 0 0
HIV Life Cycle R-HSA-162587 3.385826e-01 0.470 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.307237e-01 0.637 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.416162e-01 0.466 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.432093e-01 0.614 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.471106e-01 0.350 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.181668e-01 0.379 0 0
Interleukin-2 family signaling R-HSA-451927 2.863444e-01 0.543 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.852540e-01 0.545 0 0
Interferon gamma signaling R-HSA-877300 3.607121e-01 0.443 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.852540e-01 0.545 0 0
GABA B receptor activation R-HSA-977444 3.480063e-01 0.458 0 0
Dopamine receptors R-HSA-390651 2.307237e-01 0.637 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.740646e-01 0.562 0 0
NADPH regeneration R-HSA-389542 3.954193e-01 0.403 0 0
Apoptotic factor-mediated response R-HSA-111471 2.713995e-01 0.566 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.471106e-01 0.350 0 0
Passive transport by Aquaporins R-HSA-432047 3.932101e-01 0.405 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.980043e-01 0.526 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.474285e-01 0.349 0 0
Integration of energy metabolism R-HSA-163685 3.789531e-01 0.421 0 0
Cellular response to chemical stress R-HSA-9711123 2.714138e-01 0.566 1 0
Signaling by FGFR1 in disease R-HSA-5655302 3.271837e-01 0.485 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.225484e-01 0.491 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.367899e-01 0.360 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.593249e-01 0.445 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.740646e-01 0.562 0 0
Activation of SMO R-HSA-5635838 3.593249e-01 0.445 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.965397e-01 0.402 0 0
mRNA Editing: C to U Conversion R-HSA-72200 4.471106e-01 0.350 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.364474e-01 0.360 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.787505e-01 0.422 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.069754e-01 0.513 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.510858e-01 0.600 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.932101e-01 0.405 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.045090e-01 0.516 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.306998e-01 0.481 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.470198e-01 0.607 0 0
MET activates RAS signaling R-HSA-8851805 4.364474e-01 0.360 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.031041e-01 0.395 0 0
Eukaryotic Translation Termination R-HSA-72764 4.395141e-01 0.357 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.571521e-01 0.447 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.863930e-01 0.543 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.288855e-01 0.640 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.954193e-01 0.403 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.069754e-01 0.513 0 0
tRNA processing in the nucleus R-HSA-6784531 3.732778e-01 0.428 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.899802e-01 0.538 0 0
mRNA Editing R-HSA-75072 2.740646e-01 0.562 0 0
Protein methylation R-HSA-8876725 3.253943e-01 0.488 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.899802e-01 0.538 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.262215e-01 0.486 0 0
Signal transduction by L1 R-HSA-445144 3.295132e-01 0.482 0 0
Interleukin-7 signaling R-HSA-1266695 3.306998e-01 0.481 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.262215e-01 0.486 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.865951e-01 0.543 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.626163e-01 0.581 0 0
Signaling by ERBB4 R-HSA-1236394 2.668340e-01 0.574 0 0
Host Interactions of HIV factors R-HSA-162909 4.337641e-01 0.363 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.613593e-01 0.583 0 0
Inhibition of PKR R-HSA-169131 2.613593e-01 0.583 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.651901e-01 0.437 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.651901e-01 0.437 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.863930e-01 0.543 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.338225e-01 0.631 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.740646e-01 0.562 0 0
Formation of the Editosome R-HSA-75094 3.416162e-01 0.466 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.544305e-01 0.343 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.544305e-01 0.343 0 0
Interleukin-33 signaling R-HSA-9014843 4.544305e-01 0.343 0 0
C6 deamination of adenosine R-HSA-75102 4.544305e-01 0.343 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.584911e-01 0.588 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.288855e-01 0.640 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.559083e-01 0.449 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.253943e-01 0.488 0 0
Negative regulation of FLT3 R-HSA-9706369 3.593249e-01 0.445 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.593249e-01 0.445 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.593249e-01 0.445 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.471106e-01 0.350 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.852540e-01 0.545 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.865951e-01 0.543 0 0
FLT3 signaling in disease R-HSA-9682385 3.290320e-01 0.483 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.103193e-01 0.387 0 0
Amine ligand-binding receptors R-HSA-375280 3.901281e-01 0.409 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.093770e-01 0.388 0 0
Regulated Necrosis R-HSA-5218859 3.681832e-01 0.434 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.535527e-01 0.343 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.181668e-01 0.379 0 0
Pexophagy R-HSA-9664873 3.149333e-01 0.502 0 0
RUNX2 regulates bone development R-HSA-8941326 3.290320e-01 0.483 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.542373e-01 0.343 0 0
PECAM1 interactions R-HSA-210990 3.559083e-01 0.449 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.879700e-01 0.411 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.288855e-01 0.640 0 0
Formation of the nephric duct R-HSA-9830364 3.306998e-01 0.481 0 0
Ion transport by P-type ATPases R-HSA-936837 4.094038e-01 0.388 0 0
Signaling by NOTCH2 R-HSA-1980145 2.852540e-01 0.545 0 0
Interleukin-1 processing R-HSA-448706 2.740646e-01 0.562 0 0
Pervasive developmental disorders R-HSA-9005895 4.364474e-01 0.360 0 0
Disorders of Nervous System Development R-HSA-9697154 4.364474e-01 0.360 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.364474e-01 0.360 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.268087e-01 0.370 0 0
Other interleukin signaling R-HSA-449836 3.002337e-01 0.523 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.651901e-01 0.437 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.863930e-01 0.543 0 0
DSCAM interactions R-HSA-376172 4.544305e-01 0.343 0 0
Maturation of nucleoprotein R-HSA-9683610 2.584911e-01 0.588 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.149333e-01 0.502 0 0
Prostanoid ligand receptors R-HSA-391908 3.559083e-01 0.449 0 0
Synthesis of PI R-HSA-1483226 3.559083e-01 0.449 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 4.471106e-01 0.350 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.268087e-01 0.370 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.787505e-01 0.422 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.410666e-01 0.467 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.073821e-01 0.512 0 0
Diseases of DNA repair R-HSA-9675135 3.056408e-01 0.515 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.474285e-01 0.349 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.590471e-01 0.445 0 0
Tie2 Signaling R-HSA-210993 2.713995e-01 0.566 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.364474e-01 0.360 0 0
Inflammasomes R-HSA-622312 4.103193e-01 0.387 0 0
Co-inhibition by BTLA R-HSA-9927353 2.863930e-01 0.543 0 0
Sodium/Proton exchangers R-HSA-425986 2.338225e-01 0.631 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.066077e-01 0.513 0 0
Growth hormone receptor signaling R-HSA-982772 4.474285e-01 0.349 0 0
HDL assembly R-HSA-8963896 2.916858e-01 0.535 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.002337e-01 0.523 0 0
Specification of primordial germ cells R-HSA-9827857 4.268087e-01 0.370 0 0
Influenza Infection R-HSA-168255 3.801823e-01 0.420 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.253943e-01 0.488 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.056408e-01 0.515 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.559083e-01 0.449 0 0
GABA receptor activation R-HSA-977443 4.544478e-01 0.343 0 0
Ca2+ pathway R-HSA-4086398 4.547846e-01 0.342 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.584887e-01 0.339 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.599070e-01 0.337 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.599070e-01 0.337 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.599070e-01 0.337 0 0
Mismatch Repair R-HSA-5358508 4.599070e-01 0.337 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.599070e-01 0.337 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.599070e-01 0.337 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.630354e-01 0.334 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.630354e-01 0.334 0 0
Signaling by MET R-HSA-6806834 4.631414e-01 0.334 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.639520e-01 0.334 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.650748e-01 0.332 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.684422e-01 0.329 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.753181e-01 0.323 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.753181e-01 0.323 0 0
Frs2-mediated activation R-HSA-170968 4.753181e-01 0.323 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.753181e-01 0.323 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.753181e-01 0.323 0 0
G1/S-Specific Transcription R-HSA-69205 4.756125e-01 0.323 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.762990e-01 0.322 0 0
Deadenylation of mRNA R-HSA-429947 4.762990e-01 0.322 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.807560e-01 0.318 0 0
HIV Infection R-HSA-162906 4.835235e-01 0.316 0 0
Signaling by NOTCH3 R-HSA-9012852 4.837832e-01 0.315 0 0
Regulation of insulin secretion R-HSA-422356 4.846158e-01 0.315 0 0
EGFR downregulation R-HSA-182971 4.889545e-01 0.311 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.908553e-01 0.309 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.923193e-01 0.308 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.923193e-01 0.308 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.923193e-01 0.308 0 0
Maturation of nucleoprotein R-HSA-9694631 4.923193e-01 0.308 0 0
DNA Damage Bypass R-HSA-73893 4.953084e-01 0.305 0 0
RSK activation R-HSA-444257 4.962209e-01 0.304 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.962209e-01 0.304 0 0
Formation of annular gap junctions R-HSA-196025 4.962209e-01 0.304 0 0
MET receptor recycling R-HSA-8875656 4.962209e-01 0.304 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.962209e-01 0.304 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.962209e-01 0.304 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.962209e-01 0.304 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.962209e-01 0.304 0 0
Interleukin-9 signaling R-HSA-8985947 4.962209e-01 0.304 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.962209e-01 0.304 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.962209e-01 0.304 0 0
SLC-mediated bile acid transport R-HSA-9958517 4.962209e-01 0.304 0 0
Interleukin-18 signaling R-HSA-9012546 4.962209e-01 0.304 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.993204e-01 0.302 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.046525e-01 0.297 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 5.046525e-01 0.297 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.046525e-01 0.297 0 0
Nucleotide Excision Repair R-HSA-5696398 5.053130e-01 0.296 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.106213e-01 0.292 0 0
cGMP effects R-HSA-418457 5.129007e-01 0.290 0 0
Removal of the Flap Intermediate R-HSA-69166 5.129007e-01 0.290 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.129007e-01 0.290 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.129007e-01 0.290 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.129007e-01 0.290 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.129007e-01 0.290 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.129007e-01 0.290 0 0
DNA strand elongation R-HSA-69190 5.144549e-01 0.289 0 0
Platelet homeostasis R-HSA-418346 5.196871e-01 0.284 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.238873e-01 0.281 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.238873e-01 0.281 0 0
Protein hydroxylation R-HSA-9629569 5.238873e-01 0.281 0 0
Nephrin family interactions R-HSA-373753 5.238873e-01 0.281 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.247148e-01 0.280 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.288843e-01 0.277 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.290027e-01 0.277 0 0
Interleukin-1 signaling R-HSA-9020702 5.290968e-01 0.276 0 0
Selenocysteine synthesis R-HSA-2408557 5.290968e-01 0.276 0 0
DAP12 interactions R-HSA-2172127 5.298081e-01 0.276 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.311301e-01 0.275 0 0
Classical Kir channels R-HSA-1296053 5.311301e-01 0.275 0 0
Invadopodia formation R-HSA-8941237 5.311301e-01 0.275 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.311301e-01 0.275 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.311301e-01 0.275 0 0
MET interacts with TNS proteins R-HSA-8875513 5.311301e-01 0.275 0 0
Intracellular oxygen transport R-HSA-8981607 5.311301e-01 0.275 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.311301e-01 0.275 0 0
Histamine receptors R-HSA-390650 5.311301e-01 0.275 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.311301e-01 0.275 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.311301e-01 0.275 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.323784e-01 0.274 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.323784e-01 0.274 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.323784e-01 0.274 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.323784e-01 0.274 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.323784e-01 0.274 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.394543e-01 0.268 0 0
Nuclear RNA decay R-HSA-9930044 5.394543e-01 0.268 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.394543e-01 0.268 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.423257e-01 0.266 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.424543e-01 0.266 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 5.424543e-01 0.266 0 0
Calcineurin activates NFAT R-HSA-2025928 5.424543e-01 0.266 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.424543e-01 0.266 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.424543e-01 0.266 0 0
ARMS-mediated activation R-HSA-170984 5.424543e-01 0.266 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.424543e-01 0.266 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.424543e-01 0.266 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.456084e-01 0.263 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.456084e-01 0.263 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.490003e-01 0.260 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.490003e-01 0.260 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.490003e-01 0.260 0 0
Formation of the anterior neural plate R-HSA-9823739 5.490003e-01 0.260 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.511083e-01 0.259 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 5.544793e-01 0.256 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.544793e-01 0.256 0 0
Leishmania infection R-HSA-9658195 5.554664e-01 0.255 0 0
Parasitic Infection Pathways R-HSA-9824443 5.554664e-01 0.255 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.561159e-01 0.255 0 0
Viral mRNA Translation R-HSA-192823 5.581518e-01 0.253 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.593813e-01 0.252 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.593813e-01 0.252 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.593813e-01 0.252 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.638795e-01 0.249 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.638795e-01 0.249 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.638795e-01 0.249 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.658911e-01 0.247 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.663765e-01 0.247 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.680661e-01 0.246 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.680661e-01 0.246 0 0
HIV Transcription Elongation R-HSA-167169 5.680661e-01 0.246 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.680661e-01 0.246 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.757218e-01 0.240 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.759646e-01 0.240 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.759646e-01 0.240 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.772673e-01 0.239 0 0
Signaling by Insulin receptor R-HSA-74752 5.800381e-01 0.237 0 0
Signaling by FGFR R-HSA-190236 5.833677e-01 0.234 0 0
Phosphorylation of the APC/C R-HSA-176412 5.834728e-01 0.234 0 0
Killing mechanisms R-HSA-9664420 5.834728e-01 0.234 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.834728e-01 0.234 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.834728e-01 0.234 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.834728e-01 0.234 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.834728e-01 0.234 0 0
Prolonged ERK activation events R-HSA-169893 5.834728e-01 0.234 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.839887e-01 0.234 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.839887e-01 0.234 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.839887e-01 0.234 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.855803e-01 0.232 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.855803e-01 0.232 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.855803e-01 0.232 0 0
HIV elongation arrest and recovery R-HSA-167287 5.855803e-01 0.232 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.855803e-01 0.232 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.856492e-01 0.232 0 0
2-LTR circle formation R-HSA-164843 5.856492e-01 0.232 0 0
PI3K/AKT activation R-HSA-198203 5.856492e-01 0.232 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.857559e-01 0.232 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.876673e-01 0.231 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.876673e-01 0.231 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.876673e-01 0.231 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.899957e-01 0.229 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.924400e-01 0.227 0 0
HCN channels R-HSA-1296061 5.970505e-01 0.224 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.970505e-01 0.224 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.970505e-01 0.224 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.970505e-01 0.224 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.970505e-01 0.224 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.970505e-01 0.224 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.970505e-01 0.224 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 5.970505e-01 0.224 0 0
Transmission across Electrical Synapses R-HSA-112307 5.970505e-01 0.224 0 0
Alanine metabolism R-HSA-8964540 5.970505e-01 0.224 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.970505e-01 0.224 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.970505e-01 0.224 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.970505e-01 0.224 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.970505e-01 0.224 0 0
Aquaporin-mediated transport R-HSA-445717 5.974378e-01 0.224 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.974378e-01 0.224 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.004982e-01 0.221 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.036712e-01 0.219 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.062450e-01 0.217 0 0
PERK regulates gene expression R-HSA-381042 6.107635e-01 0.214 0 0
Late endosomal microautophagy R-HSA-9615710 6.109087e-01 0.214 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.109087e-01 0.214 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.109087e-01 0.214 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.113525e-01 0.214 0 0
Signaling by KIT in disease R-HSA-9669938 6.123320e-01 0.213 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.123320e-01 0.213 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.123320e-01 0.213 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.123320e-01 0.213 0 0
FGFR2 alternative splicing R-HSA-6803529 6.123320e-01 0.213 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.123320e-01 0.213 0 0
NGF-stimulated transcription R-HSA-9031628 6.123916e-01 0.213 0 0
Heme signaling R-HSA-9707616 6.152341e-01 0.211 0 0
Signaling by PDGF R-HSA-186797 6.152341e-01 0.211 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.162181e-01 0.210 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.162181e-01 0.210 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.162181e-01 0.210 0 0
Disorders of Developmental Biology R-HSA-9675151 6.162181e-01 0.210 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.257460e-01 0.204 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.257460e-01 0.204 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.257460e-01 0.204 0 0
Formation of the posterior neural plate R-HSA-9832991 6.257460e-01 0.204 0 0
Bicarbonate transporters R-HSA-425381 6.257460e-01 0.204 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.257460e-01 0.204 0 0
Suppression of apoptosis R-HSA-9635465 6.257460e-01 0.204 0 0
LGI-ADAM interactions R-HSA-5682910 6.257460e-01 0.204 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.277336e-01 0.202 0 0
Degradation of CDH1 R-HSA-9766229 6.318218e-01 0.199 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.320984e-01 0.199 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.320984e-01 0.199 0 0
HSF1 activation R-HSA-3371511 6.331229e-01 0.199 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.334572e-01 0.198 0 0
Developmental Cell Lineages R-HSA-9734767 6.340294e-01 0.198 0 0
Activation of the pre-replicative complex R-HSA-68962 6.353129e-01 0.197 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.353129e-01 0.197 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.353129e-01 0.197 0 0
Syndecan interactions R-HSA-3000170 6.394472e-01 0.194 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.471746e-01 0.189 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.471746e-01 0.189 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.471746e-01 0.189 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.471746e-01 0.189 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.520924e-01 0.186 0 0
SARS-CoV Infections R-HSA-9679506 6.531589e-01 0.185 0 0
Activation of AMPA receptors R-HSA-399710 6.537062e-01 0.185 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.537062e-01 0.185 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.537062e-01 0.185 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.537062e-01 0.185 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.537062e-01 0.185 0 0
PTK6 Down-Regulation R-HSA-8849472 6.537062e-01 0.185 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.537062e-01 0.185 0 0
Interleukin-36 pathway R-HSA-9014826 6.537062e-01 0.185 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.537062e-01 0.185 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.537062e-01 0.185 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.537062e-01 0.185 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.537062e-01 0.185 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.537062e-01 0.185 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.537062e-01 0.185 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.547091e-01 0.184 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.586740e-01 0.181 0 0
Budding and maturation of HIV virion R-HSA-162588 6.587518e-01 0.181 0 0
rRNA processing R-HSA-72312 6.604694e-01 0.180 0 0
Viral Infection Pathways R-HSA-9824446 6.605636e-01 0.180 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 6.627620e-01 0.179 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.627620e-01 0.179 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.627620e-01 0.179 0 0
Sodium/Calcium exchangers R-HSA-425561 6.627620e-01 0.179 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.627620e-01 0.179 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.627620e-01 0.179 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.627620e-01 0.179 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.652914e-01 0.177 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.652914e-01 0.177 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.652914e-01 0.177 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.654574e-01 0.177 0 0
MET promotes cell motility R-HSA-8875878 6.754935e-01 0.170 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.763131e-01 0.170 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.763131e-01 0.170 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.763131e-01 0.170 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.811960e-01 0.167 0 0
Extension of Telomeres R-HSA-180786 6.840836e-01 0.165 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.840836e-01 0.165 0 0
Regulation of beta-cell development R-HSA-186712 6.840836e-01 0.165 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.898393e-01 0.161 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.898393e-01 0.161 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.898393e-01 0.161 0 0
Inositol phosphate metabolism R-HSA-1483249 6.916475e-01 0.160 0 0
Stabilization of p53 R-HSA-69541 6.954552e-01 0.158 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.958056e-01 0.158 0 0
Signaling by FGFR in disease R-HSA-1226099 6.958056e-01 0.158 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.967708e-01 0.157 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.967708e-01 0.157 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.967708e-01 0.157 0 0
Plus-strand DNA synthesis R-HSA-164525 7.023987e-01 0.153 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.023987e-01 0.153 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.023987e-01 0.153 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.023987e-01 0.153 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 7.023987e-01 0.153 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.023987e-01 0.153 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.023987e-01 0.153 0 0
Ceramide signalling R-HSA-193681 7.023987e-01 0.153 0 0
Sensory perception of salty taste R-HSA-9730628 7.023987e-01 0.153 0 0
Synthesis of PS R-HSA-1483101 7.023987e-01 0.153 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 7.023987e-01 0.153 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 7.023987e-01 0.153 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 7.023987e-01 0.153 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 7.023987e-01 0.153 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 7.023987e-01 0.153 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 7.023987e-01 0.153 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.023987e-01 0.153 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.034057e-01 0.153 0 0
Translesion Synthesis by POLH R-HSA-110320 7.036318e-01 0.153 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.036318e-01 0.153 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.036318e-01 0.153 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.036318e-01 0.153 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.038357e-01 0.153 0 0
Smooth Muscle Contraction R-HSA-445355 7.038357e-01 0.153 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.084197e-01 0.150 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.084197e-01 0.150 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.084197e-01 0.150 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.130805e-01 0.147 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.130805e-01 0.147 0 0
Glycogen metabolism R-HSA-8982491 7.145804e-01 0.146 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.145804e-01 0.146 0 0
Generation of second messenger molecules R-HSA-202433 7.145804e-01 0.146 0 0
Toll-like Receptor Cascades R-HSA-168898 7.160597e-01 0.145 0 0
MAP kinase activation R-HSA-450294 7.161420e-01 0.145 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.242433e-01 0.140 0 0
Acetylcholine binding and downstream events R-HSA-181431 7.278861e-01 0.138 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.278861e-01 0.138 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 7.278861e-01 0.138 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.278861e-01 0.138 0 0
Interleukin-6 signaling R-HSA-1059683 7.278861e-01 0.138 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.278861e-01 0.138 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.278861e-01 0.138 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.278861e-01 0.138 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.278861e-01 0.138 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.278861e-01 0.138 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.291514e-01 0.137 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.291514e-01 0.137 0 0
Negative regulation of MET activity R-HSA-6807004 7.291514e-01 0.137 0 0
Signaling by NODAL R-HSA-1181150 7.291514e-01 0.137 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.291514e-01 0.137 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.313485e-01 0.136 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.346212e-01 0.134 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.350178e-01 0.134 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.350178e-01 0.134 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.380407e-01 0.132 0 0
Metal ion SLC transporters R-HSA-425410 7.423509e-01 0.129 0 0
Dual Incision in GG-NER R-HSA-5696400 7.424157e-01 0.129 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.424157e-01 0.129 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.424157e-01 0.129 0 0
Signaling by TGFB family members R-HSA-9006936 7.430170e-01 0.129 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.442470e-01 0.128 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.442470e-01 0.128 0 0
Uncoating of the HIV Virion R-HSA-162585 7.442470e-01 0.128 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.442470e-01 0.128 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.442470e-01 0.128 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.442470e-01 0.128 0 0
Abacavir transmembrane transport R-HSA-2161517 7.442470e-01 0.128 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.442470e-01 0.128 0 0
Nef and signal transduction R-HSA-164944 7.442470e-01 0.128 0 0
Lipid particle organization R-HSA-8964572 7.442470e-01 0.128 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.442470e-01 0.128 0 0
Neurofascin interactions R-HSA-447043 7.442470e-01 0.128 0 0
Signaling by GPCR R-HSA-372790 7.453998e-01 0.128 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.502973e-01 0.125 0 0
TCR signaling R-HSA-202403 7.503728e-01 0.125 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.514313e-01 0.124 0 0
TNF signaling R-HSA-75893 7.514313e-01 0.124 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.522630e-01 0.124 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.529108e-01 0.123 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.529108e-01 0.123 0 0
ERK/MAPK targets R-HSA-198753 7.529108e-01 0.123 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.544935e-01 0.122 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.552264e-01 0.122 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.552264e-01 0.122 0 0
Hedgehog 'on' state R-HSA-5632684 7.552264e-01 0.122 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.556655e-01 0.122 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.556655e-01 0.122 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.562491e-01 0.121 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.562491e-01 0.121 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.562491e-01 0.121 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.562491e-01 0.121 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.562491e-01 0.121 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.562491e-01 0.121 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.562491e-01 0.121 0 0
Prolactin receptor signaling R-HSA-1170546 7.562491e-01 0.121 0 0
Zinc transporters R-HSA-435354 7.562491e-01 0.121 0 0
IRE1alpha activates chaperones R-HSA-381070 7.571266e-01 0.121 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.602402e-01 0.119 0 0
Regulation of CDH1 Function R-HSA-9764561 7.660395e-01 0.116 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.721719e-01 0.112 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.734013e-01 0.112 0 0
Phospholipid metabolism R-HSA-1483257 7.740239e-01 0.111 0 0
mRNA Capping R-HSA-72086 7.750472e-01 0.111 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.750472e-01 0.111 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.750472e-01 0.111 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.799822e-01 0.108 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.802127e-01 0.108 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.802127e-01 0.108 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.802127e-01 0.108 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.802127e-01 0.108 0 0
Recycling of eIF2:GDP R-HSA-72731 7.802127e-01 0.108 0 0
PTK6 Expression R-HSA-8849473 7.802127e-01 0.108 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.802127e-01 0.108 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.802127e-01 0.108 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.802127e-01 0.108 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.820185e-01 0.107 0 0
Translesion synthesis by REV1 R-HSA-110312 7.820185e-01 0.107 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.820185e-01 0.107 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.820185e-01 0.107 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.820185e-01 0.107 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.820185e-01 0.107 0 0
Biotin transport and metabolism R-HSA-196780 7.820185e-01 0.107 0 0
Signaling by Activin R-HSA-1502540 7.820185e-01 0.107 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.820185e-01 0.107 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.820185e-01 0.107 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.878548e-01 0.104 0 0
The phototransduction cascade R-HSA-2514856 7.878548e-01 0.104 0 0
Cellular response to starvation R-HSA-9711097 7.878895e-01 0.104 0 0
Ribosome-associated quality control R-HSA-9948299 7.922922e-01 0.101 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.931945e-01 0.101 0 0
Degradation of DVL R-HSA-4641258 7.945119e-01 0.100 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.953725e-01 0.099 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.953725e-01 0.099 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.953725e-01 0.099 0 0
G alpha (q) signalling events R-HSA-416476 8.000733e-01 0.097 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.012884e-01 0.096 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.016052e-01 0.096 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.016052e-01 0.096 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.016052e-01 0.096 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.046681e-01 0.094 0 0
Platelet degranulation R-HSA-114608 8.051328e-01 0.094 0 0
Translesion synthesis by POLI R-HSA-5656121 8.053627e-01 0.094 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.053627e-01 0.094 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.053627e-01 0.094 0 0
Regulation of BACH1 activity R-HSA-9708530 8.053627e-01 0.094 0 0
Differentiation of T cells R-HSA-9945266 8.053627e-01 0.094 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.053627e-01 0.094 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.053627e-01 0.094 0 0
Parasite infection R-HSA-9664407 8.092920e-01 0.092 0 0
Leishmania phagocytosis R-HSA-9664417 8.092920e-01 0.092 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.092920e-01 0.092 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.101456e-01 0.091 0 0
Cargo concentration in the ER R-HSA-5694530 8.101456e-01 0.091 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.101456e-01 0.091 0 0
Transcription of the HIV genome R-HSA-167172 8.109010e-01 0.091 0 0
Reverse Transcription of HIV RNA R-HSA-162589 8.111225e-01 0.091 0 0
Minus-strand DNA synthesis R-HSA-164516 8.111225e-01 0.091 0 0
phospho-PLA2 pathway R-HSA-111995 8.111225e-01 0.091 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.111225e-01 0.091 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.111225e-01 0.091 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.111225e-01 0.091 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.111225e-01 0.091 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 8.111225e-01 0.091 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 8.111225e-01 0.091 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.111225e-01 0.091 0 0
Regulation by c-FLIP R-HSA-3371378 8.111225e-01 0.091 0 0
Co-stimulation by ICOS R-HSA-9927354 8.111225e-01 0.091 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 8.111225e-01 0.091 0 0
Dimerization of procaspase-8 R-HSA-69416 8.111225e-01 0.091 0 0
Alpha-defensins R-HSA-1462054 8.111225e-01 0.091 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 8.111225e-01 0.091 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.117233e-01 0.091 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.117233e-01 0.091 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.142112e-01 0.089 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.142112e-01 0.089 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.142112e-01 0.089 0 0
Formation of the ureteric bud R-HSA-9830674 8.142112e-01 0.089 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.182632e-01 0.087 0 0
RAS processing R-HSA-9648002 8.243943e-01 0.084 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.250706e-01 0.084 0 0
Translesion synthesis by POLK R-HSA-5655862 8.264541e-01 0.083 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.264541e-01 0.083 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.264541e-01 0.083 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.264541e-01 0.083 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.264541e-01 0.083 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.264541e-01 0.083 0 0
Synthesis of PG R-HSA-1483148 8.264541e-01 0.083 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.315572e-01 0.080 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.315572e-01 0.080 0 0
Complex III assembly R-HSA-9865881 8.315572e-01 0.080 0 0
Interleukin-17 signaling R-HSA-448424 8.330528e-01 0.079 0 0
Interleukin-21 signaling R-HSA-9020958 8.376867e-01 0.077 0 0
CASP8 activity is inhibited R-HSA-5218900 8.376867e-01 0.077 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.376867e-01 0.077 0 0
Unwinding of DNA R-HSA-176974 8.376867e-01 0.077 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 8.376867e-01 0.077 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 8.376867e-01 0.077 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.376867e-01 0.077 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.376867e-01 0.077 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.376867e-01 0.077 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.376867e-01 0.077 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.376867e-01 0.077 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.376867e-01 0.077 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.406349e-01 0.075 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.407730e-01 0.075 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.454645e-01 0.073 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.454645e-01 0.073 0 0
G protein gated Potassium channels R-HSA-1296059 8.474919e-01 0.072 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.474919e-01 0.072 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.474919e-01 0.072 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.474919e-01 0.072 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.498469e-01 0.071 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.506571e-01 0.070 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.506571e-01 0.070 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.542698e-01 0.068 0 0
Binding and entry of HIV virion R-HSA-173107 8.605163e-01 0.065 0 0
DNA replication initiation R-HSA-68952 8.605163e-01 0.065 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.605163e-01 0.065 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.605163e-01 0.065 0 0
Formation of apoptosome R-HSA-111458 8.605163e-01 0.065 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.605163e-01 0.065 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.605163e-01 0.065 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.605163e-01 0.065 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.605163e-01 0.065 0 0
Interleukin-27 signaling R-HSA-9020956 8.605163e-01 0.065 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.605163e-01 0.065 0 0
Arachidonate production from DAG R-HSA-426048 8.605163e-01 0.065 0 0
Maturation of spike protein R-HSA-9683686 8.605163e-01 0.065 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.605163e-01 0.065 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.605163e-01 0.065 0 0
Josephin domain DUBs R-HSA-5689877 8.605163e-01 0.065 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.605163e-01 0.065 0 0
Intra-Golgi traffic R-HSA-6811438 8.625146e-01 0.064 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.625146e-01 0.064 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.625146e-01 0.064 0 0
Translation of Structural Proteins R-HSA-9683701 8.625146e-01 0.064 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.625619e-01 0.064 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.625619e-01 0.064 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.625619e-01 0.064 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.643184e-01 0.063 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.668996e-01 0.062 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.701289e-01 0.060 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.701569e-01 0.060 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.754606e-01 0.058 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.754606e-01 0.058 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.765255e-01 0.057 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.779083e-01 0.057 0 0
Regulation of signaling by CBL R-HSA-912631 8.779083e-01 0.057 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 8.779083e-01 0.057 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.779083e-01 0.057 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.779083e-01 0.057 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.785769e-01 0.056 0 0
Kidney development R-HSA-9830369 8.791290e-01 0.056 0 0
Gastrulation R-HSA-9758941 8.794849e-01 0.056 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.801359e-01 0.055 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.801359e-01 0.055 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.801359e-01 0.055 0 0
vRNA Synthesis R-HSA-192814 8.801359e-01 0.055 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.801359e-01 0.055 0 0
Transport of RCbl within the body R-HSA-9758890 8.801359e-01 0.055 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.801359e-01 0.055 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.801359e-01 0.055 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.801359e-01 0.055 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.801359e-01 0.055 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.822766e-01 0.054 0 0
Potential therapeutics for SARS R-HSA-9679191 8.852189e-01 0.053 0 0
Telomere Extension By Telomerase R-HSA-171319 8.876609e-01 0.052 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.893547e-01 0.051 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.893547e-01 0.051 0 0
Triglyceride catabolism R-HSA-163560 8.893547e-01 0.051 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.899802e-01 0.051 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.916580e-01 0.050 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.916580e-01 0.050 0 0
Glycogen synthesis R-HSA-3322077 8.916580e-01 0.050 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.933647e-01 0.049 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.934290e-01 0.049 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.969969e-01 0.047 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.969969e-01 0.047 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.969969e-01 0.047 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.969969e-01 0.047 0 0
ERKs are inactivated R-HSA-202670 8.969969e-01 0.047 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.987806e-01 0.046 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.992857e-01 0.046 0 0
PCP/CE pathway R-HSA-4086400 9.020231e-01 0.045 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.023063e-01 0.045 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.023063e-01 0.045 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.039563e-01 0.044 0 0
G-protein activation R-HSA-202040 9.039563e-01 0.044 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.039563e-01 0.044 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 9.039563e-01 0.044 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.039563e-01 0.044 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.039563e-01 0.044 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.039563e-01 0.044 0 0
Basigin interactions R-HSA-210991 9.039563e-01 0.044 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.039563e-01 0.044 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.084217e-01 0.042 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.084217e-01 0.042 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.086726e-01 0.042 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.088981e-01 0.041 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.105326e-01 0.041 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.114868e-01 0.040 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.114868e-01 0.040 0 0
Interleukin-35 Signalling R-HSA-8984722 9.114868e-01 0.040 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.114868e-01 0.040 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.114868e-01 0.040 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.114868e-01 0.040 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.114868e-01 0.040 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.114868e-01 0.040 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.114868e-01 0.040 0 0
OAS antiviral response R-HSA-8983711 9.114868e-01 0.040 0 0
Estrogen biosynthesis R-HSA-193144 9.114868e-01 0.040 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.114868e-01 0.040 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.149396e-01 0.039 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.149396e-01 0.039 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.168136e-01 0.038 0 0
Interferon alpha/beta signaling R-HSA-909733 9.211454e-01 0.036 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.239392e-01 0.034 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.239392e-01 0.034 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.239392e-01 0.034 0 0
Chylomicron remodeling R-HSA-8963901 9.239392e-01 0.034 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.239392e-01 0.034 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.239392e-01 0.034 0 0
Processing of SMDT1 R-HSA-8949664 9.239392e-01 0.034 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.239392e-01 0.034 0 0
Cellular response to hypoxia R-HSA-1234174 9.241475e-01 0.034 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.245108e-01 0.034 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.245108e-01 0.034 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.245108e-01 0.034 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.247342e-01 0.034 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.247342e-01 0.034 0 0
ER-Phagosome pathway R-HSA-1236974 9.255209e-01 0.034 0 0
Mitochondrial biogenesis R-HSA-1592230 9.302541e-01 0.031 0 0
Neurotransmitter release cycle R-HSA-112310 9.305759e-01 0.031 0 0
Maturation of spike protein R-HSA-9694548 9.315609e-01 0.031 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.315741e-01 0.031 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.316715e-01 0.031 0 0
Dual incision in TC-NER R-HSA-6782135 9.331705e-01 0.030 0 0
Interleukin-20 family signaling R-HSA-8854691 9.334572e-01 0.030 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.334572e-01 0.030 0 0
Biosynthesis of maresins R-HSA-9018682 9.334572e-01 0.030 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.346403e-01 0.029 0 0
Hydrolysis of LPC R-HSA-1483115 9.346403e-01 0.029 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.346403e-01 0.029 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.346403e-01 0.029 0 0
Physiological factors R-HSA-5578768 9.346403e-01 0.029 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.346403e-01 0.029 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.346403e-01 0.029 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.346403e-01 0.029 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.346403e-01 0.029 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.346403e-01 0.029 0 0
P2Y receptors R-HSA-417957 9.346403e-01 0.029 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.380096e-01 0.028 0 0
HIV Transcription Initiation R-HSA-167161 9.380096e-01 0.028 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.380096e-01 0.028 0 0
Triglyceride metabolism R-HSA-8979227 9.386859e-01 0.027 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.390081e-01 0.027 0 0
Interleukin-6 family signaling R-HSA-6783589 9.412162e-01 0.026 0 0
Translation of Structural Proteins R-HSA-9694635 9.427927e-01 0.026 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.438364e-01 0.025 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.438364e-01 0.025 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.438364e-01 0.025 0 0
Transport and metabolism of PAPS R-HSA-174362 9.438364e-01 0.025 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 9.438364e-01 0.025 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.438364e-01 0.025 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.438364e-01 0.025 0 0
Other semaphorin interactions R-HSA-416700 9.438364e-01 0.025 0 0
DNA Damage Reversal R-HSA-73942 9.438364e-01 0.025 0 0
Selenoamino acid metabolism R-HSA-2408522 9.448976e-01 0.025 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.462759e-01 0.024 0 0
Synthesis of DNA R-HSA-69239 9.463297e-01 0.024 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.469773e-01 0.024 0 0
Hyaluronan metabolism R-HSA-2142845 9.469773e-01 0.024 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.481098e-01 0.023 0 0
Hyaluronan degradation R-HSA-2160916 9.481098e-01 0.023 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.489640e-01 0.023 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.492759e-01 0.023 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.492759e-01 0.023 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.492759e-01 0.023 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.493217e-01 0.023 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.498837e-01 0.022 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.517390e-01 0.021 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.517390e-01 0.021 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.517390e-01 0.021 0 0
Fructose catabolism R-HSA-70350 9.517390e-01 0.021 0 0
Attachment and Entry R-HSA-9678110 9.517390e-01 0.021 0 0
Atorvastatin ADME R-HSA-9754706 9.517390e-01 0.021 0 0
Regulation of Apoptosis R-HSA-169911 9.525442e-01 0.021 0 0
Mitochondrial protein import R-HSA-1268020 9.528764e-01 0.021 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.537651e-01 0.021 0 0
MET activates PTK2 signaling R-HSA-8874081 9.542278e-01 0.020 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.542278e-01 0.020 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.554386e-01 0.020 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.575611e-01 0.019 0 0
Glycosphingolipid transport R-HSA-9845576 9.575611e-01 0.019 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.585301e-01 0.018 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.585301e-01 0.018 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.585301e-01 0.018 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.585301e-01 0.018 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.585301e-01 0.018 0 0
Fibronectin matrix formation R-HSA-1566977 9.585301e-01 0.018 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.585301e-01 0.018 0 0
Galactose catabolism R-HSA-70370 9.585301e-01 0.018 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.585301e-01 0.018 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.586334e-01 0.018 0 0
Cristae formation R-HSA-8949613 9.596519e-01 0.018 0 0
Triglyceride biosynthesis R-HSA-75109 9.596519e-01 0.018 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.609266e-01 0.017 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.620772e-01 0.017 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.620772e-01 0.017 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.626879e-01 0.017 0 0
Downstream TCR signaling R-HSA-202424 9.628708e-01 0.016 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.643659e-01 0.016 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.643659e-01 0.016 0 0
Glycogen storage diseases R-HSA-3229121 9.643659e-01 0.016 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.643659e-01 0.016 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.643659e-01 0.016 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.643659e-01 0.016 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.643659e-01 0.016 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.643659e-01 0.016 0 0
Choline catabolism R-HSA-6798163 9.643659e-01 0.016 0 0
Insulin receptor recycling R-HSA-77387 9.644562e-01 0.016 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.646450e-01 0.016 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.663707e-01 0.015 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.663707e-01 0.015 0 0
Synthesis of PC R-HSA-1483191 9.663707e-01 0.015 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.671381e-01 0.015 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.687078e-01 0.014 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.693808e-01 0.014 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.693808e-01 0.014 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.693808e-01 0.014 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.693808e-01 0.014 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.694754e-01 0.013 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.697862e-01 0.013 0 0
Pentose phosphate pathway R-HSA-71336 9.697862e-01 0.013 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.709142e-01 0.013 0 0
Neurotransmitter clearance R-HSA-112311 9.724670e-01 0.012 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.724670e-01 0.012 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.730601e-01 0.012 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.736901e-01 0.012 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.736901e-01 0.012 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.736901e-01 0.012 0 0
Interleukin-10 signaling R-HSA-6783783 9.747809e-01 0.011 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.757882e-01 0.011 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.757882e-01 0.011 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.759954e-01 0.011 0 0
G alpha (i) signalling events R-HSA-418594 9.767527e-01 0.010 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.769406e-01 0.010 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.773932e-01 0.010 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.773932e-01 0.010 0 0
Keratan sulfate degradation R-HSA-2022857 9.773932e-01 0.010 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.773932e-01 0.010 0 0
Pregnenolone biosynthesis R-HSA-196108 9.773932e-01 0.010 0 0
Circadian clock R-HSA-9909396 9.775225e-01 0.010 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.779675e-01 0.010 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.804773e-01 0.009 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.805752e-01 0.009 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.805752e-01 0.009 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.805752e-01 0.009 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.809782e-01 0.008 0 0
Neddylation R-HSA-8951664 9.820935e-01 0.008 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.830827e-01 0.007 0 0
Eicosanoids R-HSA-211979 9.833096e-01 0.007 0 0
Miscellaneous substrates R-HSA-211958 9.833096e-01 0.007 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.833096e-01 0.007 0 0
Glutathione synthesis and recycling R-HSA-174403 9.833096e-01 0.007 0 0
Attachment and Entry R-HSA-9694614 9.833096e-01 0.007 0 0
Assembly Of The HIV Virion R-HSA-175474 9.833096e-01 0.007 0 0
Heme degradation R-HSA-189483 9.835868e-01 0.007 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.839802e-01 0.007 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.840678e-01 0.007 0 0
Surfactant metabolism R-HSA-5683826 9.849633e-01 0.007 0 0
eNOS activation R-HSA-203615 9.855956e-01 0.006 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.855956e-01 0.006 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.855956e-01 0.006 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.856591e-01 0.006 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.856591e-01 0.006 0 0
LDL clearance R-HSA-8964038 9.856591e-01 0.006 0 0
Fructose metabolism R-HSA-5652084 9.856591e-01 0.006 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.856591e-01 0.006 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.857174e-01 0.006 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.860161e-01 0.006 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.863530e-01 0.006 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.866425e-01 0.006 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.866425e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.870293e-01 0.006 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.873642e-01 0.006 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.873642e-01 0.006 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.873642e-01 0.006 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.876780e-01 0.005 0 0
Fatty acids R-HSA-211935 9.876780e-01 0.005 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.876780e-01 0.005 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.876780e-01 0.005 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.876780e-01 0.005 0 0
Carnitine shuttle R-HSA-200425 9.876780e-01 0.005 0 0
Synthesis of PA R-HSA-1483166 9.885420e-01 0.005 0 0
Mitochondrial protein degradation R-HSA-9837999 9.886001e-01 0.005 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.889205e-01 0.005 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.892638e-01 0.005 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.892638e-01 0.005 0 0
CYP2E1 reactions R-HSA-211999 9.894128e-01 0.005 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.894128e-01 0.005 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.894128e-01 0.005 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.894128e-01 0.005 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.894128e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.895920e-01 0.005 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.901996e-01 0.004 0 0
NCAM1 interactions R-HSA-419037 9.902891e-01 0.004 0 0
Gluconeogenesis R-HSA-70263 9.906666e-01 0.004 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.909035e-01 0.004 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.909035e-01 0.004 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.914921e-01 0.004 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.918014e-01 0.004 0 0
Abacavir ADME R-HSA-2161522 9.921843e-01 0.003 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.921843e-01 0.003 0 0
Protein localization R-HSA-9609507 9.922452e-01 0.003 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.925489e-01 0.003 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.925489e-01 0.003 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.925489e-01 0.003 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.926747e-01 0.003 0 0
tRNA processing R-HSA-72306 9.927095e-01 0.003 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.932849e-01 0.003 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.932849e-01 0.003 0 0
Synthesis of PE R-HSA-1483213 9.932849e-01 0.003 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.932849e-01 0.003 0 0
Insulin processing R-HSA-264876 9.932849e-01 0.003 0 0
Signaling by BMP R-HSA-201451 9.932849e-01 0.003 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.932849e-01 0.003 0 0
PPARA activates gene expression R-HSA-1989781 9.933398e-01 0.003 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.935079e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.940249e-01 0.003 0 0
Prednisone ADME R-HSA-9757110 9.942305e-01 0.003 0 0
Pyrimidine salvage R-HSA-73614 9.942305e-01 0.003 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.942532e-01 0.003 0 0
Orc1 removal from chromatin R-HSA-68949 9.942532e-01 0.003 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.942890e-01 0.002 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.942913e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.942913e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.944430e-01 0.002 0 0
SLC transporter disorders R-HSA-5619102 9.948272e-01 0.002 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.949152e-01 0.002 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.949152e-01 0.002 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.949981e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.950237e-01 0.002 0 0
Thyroxine biosynthesis R-HSA-209968 9.950430e-01 0.002 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.950430e-01 0.002 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.950430e-01 0.002 0 0
Infectious disease R-HSA-5663205 9.953403e-01 0.002 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.956323e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.957377e-01 0.002 0 0
Mucopolysaccharidoses R-HSA-2206281 9.957411e-01 0.002 0 0
Disease R-HSA-1643685 9.962678e-01 0.002 0 0
Nicotinate metabolism R-HSA-196807 9.963114e-01 0.002 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.963410e-01 0.002 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.963410e-01 0.002 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.963410e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.963410e-01 0.002 0 0
ABC transporter disorders R-HSA-5619084 9.963919e-01 0.002 0 0
Proteasome assembly R-HSA-9907900 9.966626e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.966626e-01 0.001 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.968564e-01 0.001 0 0
HS-GAG degradation R-HSA-2024096 9.968564e-01 0.001 0 0
Somitogenesis R-HSA-9824272 9.970840e-01 0.001 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.972992e-01 0.001 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.972992e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.973984e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.975814e-01 0.001 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.975814e-01 0.001 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.976796e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.976796e-01 0.001 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.976796e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.976862e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.978660e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.979429e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.980055e-01 0.001 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.980065e-01 0.001 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.980065e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.981178e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.982874e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.984317e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.985213e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.985579e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.985720e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.987360e-01 0.001 0 0
Degradation of AXIN R-HSA-4641257 9.987360e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.987360e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.987360e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.987360e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.987360e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.988634e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.988816e-01 0.000 0 0
Purine salvage R-HSA-74217 9.989141e-01 0.000 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.989141e-01 0.000 0 0
Elastic fibre formation R-HSA-1566948 9.989141e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.989924e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.990192e-01 0.000 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.990671e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.991640e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.991986e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.992258e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.992535e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.992548e-01 0.000 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.994086e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.994086e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.994086e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.994344e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.994733e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.995298e-01 0.000 0 0
Defensins R-HSA-1461973 9.995636e-01 0.000 0 0
RSV-host interactions R-HSA-9833110 9.995697e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.996251e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.996265e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.996265e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.996426e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.996587e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.996625e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.996749e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.996779e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.996779e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.997015e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.997233e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.997328e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997538e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.997623e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997858e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997858e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.997959e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.998246e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.998246e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.998494e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.998591e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998591e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998706e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999023e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999196e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999196e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999196e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999243e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999286e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999301e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999393e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999395e-01 0.000 0 0
Digestion R-HSA-8935690 9.999395e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999617e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.999617e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999671e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999700e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999717e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999791e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999804e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999804e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999846e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999883e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999885e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999889e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999904e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999913e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999928e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999928e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999937e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999949e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999954e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999970e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999973e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999982e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999985e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999990e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999991e-01 0.000 0 0
Translation R-HSA-72766 9.999994e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999995e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999996e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999996e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999998e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999998e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999998e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 1 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 1 0
M Phase R-HSA-68886 3.330669e-16 15.477 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.218847e-15 14.375 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.218847e-15 14.375 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.210143e-14 13.917 0 0
Signaling by ROBO receptors R-HSA-376176 3.119727e-14 13.506 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.685141e-14 13.329 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.496403e-14 13.347 0 0
Cell Cycle Checkpoints R-HSA-69620 4.340972e-14 13.362 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.764144e-13 12.753 0 0
Cellular response to heat stress R-HSA-3371556 8.252288e-13 12.083 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.353673e-12 11.628 0 0
Apoptotic execution phase R-HSA-75153 5.785483e-12 11.238 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.869150e-12 11.104 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.049783e-12 11.094 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.611100e-11 10.583 0 0
Ribosome-associated quality control R-HSA-9948299 2.984946e-11 10.525 0 0
Peptide chain elongation R-HSA-156902 3.519574e-11 10.454 0 0
Signal Transduction R-HSA-162582 6.233847e-11 10.205 1 0
Apoptosis R-HSA-109581 6.744516e-11 10.171 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.146051e-11 10.089 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.146051e-11 10.089 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 8.005119e-11 10.097 0 0
G2/M Checkpoints R-HSA-69481 1.589537e-10 9.799 0 0
Cell-Cell communication R-HSA-1500931 1.538483e-10 9.813 1 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.967597e-10 9.528 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.145212e-10 9.502 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.715058e-10 9.243 0 0
Translation initiation complex formation R-HSA-72649 6.208830e-10 9.207 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.875494e-10 9.163 0 0
Influenza Infection R-HSA-168255 6.856569e-10 9.164 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.746456e-10 9.058 0 0
Signaling by ALK in cancer R-HSA-9700206 8.746456e-10 9.058 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.231541e-09 8.910 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.092666e-09 8.679 0 0
Separation of Sister Chromatids R-HSA-2467813 2.130658e-09 8.671 0 0
Cellular Senescence R-HSA-2559583 2.150911e-09 8.667 0 0
Interleukin-12 signaling R-HSA-9020591 2.317553e-09 8.635 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.786017e-09 8.555 0 0
Mitotic Anaphase R-HSA-68882 3.017610e-09 8.520 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.132127e-09 8.504 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.508412e-09 8.455 0 0
HSF1-dependent transactivation R-HSA-3371571 4.087225e-09 8.389 0 0
Chromatin organization R-HSA-4839726 4.628587e-09 8.335 0 0
Eukaryotic Translation Termination R-HSA-72764 4.589552e-09 8.338 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.512571e-09 8.346 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.512571e-09 8.346 0 0
HSF1 activation R-HSA-3371511 4.661846e-09 8.331 0 0
Mitotic Prophase R-HSA-68875 7.441403e-09 8.128 0 0
Cell junction organization R-HSA-446728 8.234268e-09 8.084 1 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.698716e-09 8.061 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.105321e-08 7.957 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.355903e-08 7.868 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.334917e-08 7.875 0 0
Interleukin-12 family signaling R-HSA-447115 1.494175e-08 7.826 0 0
Chromatin modifying enzymes R-HSA-3247509 1.695416e-08 7.771 0 0
Mitotic Prometaphase R-HSA-68877 1.720013e-08 7.764 0 0
Selenocysteine synthesis R-HSA-2408557 1.801521e-08 7.744 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.879570e-08 7.726 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.200536e-08 7.657 0 0
Attenuation phase R-HSA-3371568 2.200536e-08 7.657 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.140256e-08 7.670 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.377004e-08 7.624 0 0
Viral mRNA Translation R-HSA-192823 2.775921e-08 7.557 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.787756e-08 7.555 0 0
Metabolism of RNA R-HSA-8953854 4.273653e-08 7.369 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.641793e-08 7.333 0 0
Programmed Cell Death R-HSA-5357801 4.812928e-08 7.318 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.415649e-08 7.130 0 0
L1CAM interactions R-HSA-373760 8.107035e-08 7.091 0 0
Cellular response to starvation R-HSA-9711097 9.367522e-08 7.028 0 0
Adherens junctions interactions R-HSA-418990 1.235078e-07 6.908 0 0
Cell-cell junction organization R-HSA-421270 1.532024e-07 6.815 1 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.817290e-07 6.741 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.263999e-07 6.645 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.378059e-07 6.624 0 0
Recycling pathway of L1 R-HSA-437239 3.112441e-07 6.507 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.117018e-07 6.506 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.984680e-07 6.400 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.577549e-07 6.339 0 0
G2/M Transition R-HSA-69275 4.772629e-07 6.321 0 0
RNA Polymerase I Transcription R-HSA-73864 5.129929e-07 6.290 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.253746e-07 6.204 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.253746e-07 6.204 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.540054e-07 6.184 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.583365e-07 6.182 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.299072e-07 6.137 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.508584e-07 6.124 0 0
HDACs deacetylate histones R-HSA-3214815 7.950236e-07 6.100 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.293850e-07 6.081 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.877550e-07 6.052 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.877550e-07 6.052 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.877550e-07 6.052 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.441835e-07 6.074 0 0
Signaling by RAS mutants R-HSA-6802949 8.877550e-07 6.052 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.417996e-07 6.075 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 9.021286e-07 6.045 0 0
HATs acetylate histones R-HSA-3214847 9.106653e-07 6.041 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.928200e-07 6.003 0 0
UCH proteinases R-HSA-5689603 1.029940e-06 5.987 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.029940e-06 5.987 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.116164e-06 5.952 0 0
Packaging Of Telomere Ends R-HSA-171306 1.116164e-06 5.952 0 0
DNA Double Strand Break Response R-HSA-5693606 1.354906e-06 5.868 0 0
DNA Replication R-HSA-69306 1.571000e-06 5.804 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.586648e-06 5.800 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.657319e-06 5.781 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.711723e-06 5.767 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.154238e-06 5.667 0 0
DNA methylation R-HSA-5334118 2.345048e-06 5.630 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.491276e-06 5.604 0 0
Nucleosome assembly R-HSA-774815 2.491276e-06 5.604 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.621475e-06 5.581 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.999556e-06 5.523 0 0
Viral Infection Pathways R-HSA-9824446 4.083930e-06 5.389 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.100431e-06 5.387 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.129497e-06 5.384 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.055640e-06 5.296 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.544577e-06 5.256 0 0
Meiotic synapsis R-HSA-1221632 5.675758e-06 5.246 0 0
Developmental Biology R-HSA-1266738 6.281147e-06 5.202 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.367158e-06 5.196 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.454003e-06 5.190 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.487634e-06 5.188 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.518953e-06 5.186 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.743690e-06 5.171 0 0
Deubiquitination R-HSA-5688426 8.987252e-06 5.046 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.903923e-06 5.050 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.880955e-06 5.005 0 0
ESR-mediated signaling R-HSA-8939211 1.104017e-05 4.957 0 0
MAP2K and MAPK activation R-HSA-5674135 1.104055e-05 4.957 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.118044e-05 4.952 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.382518e-05 4.859 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.392956e-05 4.856 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.475517e-05 4.831 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.601910e-05 4.795 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.722055e-05 4.764 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.882101e-05 4.725 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.130201e-05 4.672 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.130201e-05 4.672 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.179648e-05 4.662 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.258832e-05 4.646 0 0
Signaling by ERBB2 R-HSA-1227986 2.751243e-05 4.560 0 0
Translation R-HSA-72766 2.932005e-05 4.533 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.242958e-05 4.489 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.227326e-05 4.491 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.420317e-05 4.466 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.420317e-05 4.466 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.735302e-05 4.428 0 0
Cleavage of the damaged purine R-HSA-110331 3.735302e-05 4.428 0 0
MAPK family signaling cascades R-HSA-5683057 3.756520e-05 4.425 0 0
Signaling by Hippo R-HSA-2028269 3.878763e-05 4.411 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.016434e-05 4.396 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.096785e-05 4.388 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.138244e-05 4.383 0 0
Regulation of CDH1 Function R-HSA-9764561 4.434042e-05 4.353 0 0
S Phase R-HSA-69242 4.831920e-05 4.316 0 0
Depurination R-HSA-73927 4.847095e-05 4.315 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.922639e-05 4.308 0 0
Depyrimidination R-HSA-73928 4.922639e-05 4.308 0 0
rRNA processing R-HSA-72312 5.002944e-05 4.301 0 0
Semaphorin interactions R-HSA-373755 5.042699e-05 4.297 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.104371e-05 4.292 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.150045e-05 4.288 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.385303e-05 4.269 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.419679e-05 4.266 0 0
Defective pyroptosis R-HSA-9710421 6.241571e-05 4.205 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.359096e-05 4.197 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.692731e-05 4.174 0 0
Selenoamino acid metabolism R-HSA-2408522 6.959918e-05 4.157 0 0
Signaling by WNT R-HSA-195721 6.967323e-05 4.157 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.518889e-05 4.124 0 0
Homology Directed Repair R-HSA-5693538 7.678832e-05 4.115 0 0
Aggrephagy R-HSA-9646399 7.974652e-05 4.098 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.012324e-05 4.096 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.159900e-05 4.088 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.011142e-04 3.995 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.011749e-04 3.995 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.011749e-04 3.995 0 0
Ub-specific processing proteases R-HSA-5689880 1.014162e-04 3.994 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.045085e-04 3.981 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.045085e-04 3.981 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.124907e-04 3.949 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.136471e-04 3.944 0 0
Meiotic recombination R-HSA-912446 1.154210e-04 3.938 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.224901e-04 3.912 0 0
Base Excision Repair R-HSA-73884 1.240820e-04 3.906 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.258645e-04 3.900 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.293637e-04 3.888 0 0
HCMV Early Events R-HSA-9609690 1.370757e-04 3.863 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.396727e-04 3.855 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.414250e-04 3.849 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.424451e-04 3.846 0 0
Host Interactions of HIV factors R-HSA-162909 1.658379e-04 3.780 0 0
mRNA Splicing R-HSA-72172 1.695182e-04 3.771 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.058323e-04 3.686 0 0
Signaling by VEGF R-HSA-194138 2.115695e-04 3.675 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.092309e-04 3.679 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.245523e-04 3.649 0 0
Selective autophagy R-HSA-9663891 2.245523e-04 3.649 0 0
Diseases of programmed cell death R-HSA-9645723 2.245523e-04 3.649 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.276611e-04 3.643 0 0
Degradation of CDH1 R-HSA-9766229 2.281823e-04 3.642 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.352359e-04 3.628 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.415024e-04 3.617 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.512860e-04 3.600 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.545252e-04 3.594 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.590348e-04 3.587 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.610216e-04 3.583 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.832839e-04 3.548 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.832839e-04 3.548 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.951939e-04 3.530 0 0
Signaling by Interleukins R-HSA-449147 2.963544e-04 3.528 0 0
Meiosis R-HSA-1500620 3.015924e-04 3.521 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.100372e-04 3.509 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.420977e-04 3.466 0 0
FLT3 Signaling R-HSA-9607240 3.219967e-04 3.492 0 0
Gene Silencing by RNA R-HSA-211000 3.628411e-04 3.440 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.637731e-04 3.439 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.937811e-04 3.405 0 0
Protein ubiquitination R-HSA-8852135 4.035532e-04 3.394 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.053132e-04 3.392 0 0
Orc1 removal from chromatin R-HSA-68949 4.056829e-04 3.392 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.284050e-04 3.368 0 0
G1/S Transition R-HSA-69206 4.489607e-04 3.348 0 0
Post NMDA receptor activation events R-HSA-438064 4.635704e-04 3.334 0 0
Chromosome Maintenance R-HSA-73886 5.324043e-04 3.274 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.435538e-04 3.265 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.722410e-04 3.242 1 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.814719e-04 3.235 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.047696e-04 3.218 0 0
Kinesins R-HSA-983189 6.089201e-04 3.215 0 0
PTEN Regulation R-HSA-6807070 6.104239e-04 3.214 0 0
Signaling by NOTCH R-HSA-157118 6.202970e-04 3.207 1 0
AURKA Activation by TPX2 R-HSA-8854518 6.252587e-04 3.204 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.297004e-04 3.201 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.307696e-04 3.200 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.455839e-04 3.190 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.913168e-04 3.102 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.979973e-04 3.098 0 0
PECAM1 interactions R-HSA-210990 9.647711e-04 3.016 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 9.647711e-04 3.016 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.960582e-04 3.048 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.960582e-04 3.048 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.846057e-04 3.007 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.846057e-04 3.007 0 0
Telomere Maintenance R-HSA-157579 9.823397e-04 3.008 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.823397e-04 3.008 0 0
Metalloprotease DUBs R-HSA-5689901 9.123900e-04 3.040 0 0
Signaling by PTK6 R-HSA-8848021 9.846057e-04 3.007 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.846057e-04 3.007 0 0
Signaling by NOTCH4 R-HSA-9013694 8.490220e-04 3.071 0 0
Amyloid fiber formation R-HSA-977225 9.613950e-04 3.017 0 0
SARS-CoV Infections R-HSA-9679506 9.778046e-04 3.010 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.100458e-03 2.958 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.132904e-03 2.946 1 1
Negative regulation of MAPK pathway R-HSA-5675221 1.167066e-03 2.933 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.270447e-03 2.896 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.280073e-03 2.893 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.280073e-03 2.893 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.280073e-03 2.893 0 0
Degradation of DVL R-HSA-4641258 1.284698e-03 2.891 0 0
Integrin signaling R-HSA-354192 1.389796e-03 2.857 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.389796e-03 2.857 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.422461e-03 2.847 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.426393e-03 2.846 0 0
Regulation of signaling by CBL R-HSA-912631 1.446135e-03 2.840 0 0
Macroautophagy R-HSA-1632852 1.459451e-03 2.836 0 0
G alpha (12/13) signalling events R-HSA-416482 1.480010e-03 2.830 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.548369e-03 2.810 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.682025e-03 2.774 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.710350e-03 2.767 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.710350e-03 2.767 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.741475e-03 2.759 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.741475e-03 2.759 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.756758e-03 2.755 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.756758e-03 2.755 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.757968e-03 2.755 0 0
Autophagy R-HSA-9612973 1.789696e-03 2.747 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.046830e-03 2.689 0 0
Centrosome maturation R-HSA-380287 2.271960e-03 2.644 0 0
Signaling by EGFR R-HSA-177929 2.092002e-03 2.679 0 0
EPH-Ephrin signaling R-HSA-2682334 2.227299e-03 2.652 0 0
Signal transduction by L1 R-HSA-445144 1.900672e-03 2.721 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.044506e-03 2.689 0 0
Nuclear import of Rev protein R-HSA-180746 2.089301e-03 2.680 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.909974e-03 2.719 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.265383e-03 2.645 0 0
Negative regulation of MET activity R-HSA-6807004 1.900672e-03 2.721 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.100724e-03 2.678 0 0
DNA Repair R-HSA-73894 1.898793e-03 2.722 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.964841e-03 2.707 0 0
Interferon Signaling R-HSA-913531 2.022414e-03 2.694 0 0
NRAGE signals death through JNK R-HSA-193648 2.092002e-03 2.679 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.323547e-03 2.634 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.402365e-03 2.619 0 0
Long-term potentiation R-HSA-9620244 2.411344e-03 2.618 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.462657e-03 2.609 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.462657e-03 2.609 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.534293e-03 2.596 0 0
Regulation of Apoptosis R-HSA-169911 2.534293e-03 2.596 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.573568e-03 2.589 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.669490e-03 2.574 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.683132e-03 2.571 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.704357e-03 2.568 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.704357e-03 2.568 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.704357e-03 2.568 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.830410e-03 2.548 0 0
Gene expression (Transcription) R-HSA-74160 3.029084e-03 2.519 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.129535e-03 2.505 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.148999e-03 2.502 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.149003e-03 2.502 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.210505e-03 2.493 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.237271e-03 2.490 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.237271e-03 2.490 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.237271e-03 2.490 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.290451e-03 2.483 0 0
PCP/CE pathway R-HSA-4086400 3.318081e-03 2.479 0 0
Synthesis of DNA R-HSA-69239 3.360973e-03 2.474 0 0
HIV Infection R-HSA-162906 3.443425e-03 2.463 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.476667e-03 2.459 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.617225e-03 2.442 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.617540e-03 2.442 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.655643e-03 2.437 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.728987e-03 2.428 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.728987e-03 2.428 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.883164e-03 2.411 0 0
Regulation of KIT signaling R-HSA-1433559 3.883164e-03 2.411 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.977727e-03 2.400 0 0
mTORC1-mediated signalling R-HSA-166208 3.977727e-03 2.400 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.070858e-03 2.390 0 0
PKR-mediated signaling R-HSA-9833482 4.217370e-03 2.375 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.217370e-03 2.375 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.349894e-03 2.362 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.395097e-03 2.357 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.397556e-03 2.357 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.616842e-03 2.336 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.175323e-03 2.286 0 0
RAF activation R-HSA-5673000 5.904165e-03 2.229 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.051099e-03 2.297 0 0
Neutrophil degranulation R-HSA-6798695 5.437269e-03 2.265 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.051099e-03 2.297 0 0
Translesion Synthesis by POLH R-HSA-110320 5.216592e-03 2.283 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.207024e-03 2.283 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.166141e-03 2.287 0 0
HCMV Infection R-HSA-9609646 5.825369e-03 2.235 0 0
Mitophagy R-HSA-5205647 5.904165e-03 2.229 0 0
Muscle contraction R-HSA-397014 5.606822e-03 2.251 0 0
Regulation of PTEN localization R-HSA-8948747 5.032783e-03 2.298 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.145915e-03 2.289 0 0
Vpu mediated degradation of CD4 R-HSA-180534 4.948261e-03 2.306 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.904165e-03 2.229 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.904165e-03 2.229 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.958665e-03 2.225 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.987013e-03 2.223 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.987013e-03 2.223 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.053786e-03 2.218 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.053786e-03 2.218 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.058788e-03 2.218 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.058788e-03 2.218 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.058788e-03 2.218 0 0
Co-inhibition by PD-1 R-HSA-389948 6.338947e-03 2.198 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.386726e-03 2.195 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.386726e-03 2.195 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.593572e-03 2.181 0 0
Nephrin family interactions R-HSA-373753 6.593572e-03 2.181 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.707944e-03 2.173 0 0
Activation of the pre-replicative complex R-HSA-68962 6.707944e-03 2.173 0 0
Negative regulation of FLT3 R-HSA-9706369 6.766088e-03 2.170 0 0
mRNA 3'-end processing R-HSA-72187 6.845765e-03 2.165 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.999562e-03 2.155 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.999562e-03 2.155 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.017983e-03 2.154 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.083963e-03 2.150 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.083963e-03 2.150 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.372697e-03 2.132 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.428692e-03 2.129 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.512325e-03 2.124 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.512325e-03 2.124 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.512325e-03 2.124 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.583420e-03 2.120 1 1
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.030248e-03 2.095 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.030248e-03 2.095 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.093635e-03 2.092 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.247234e-03 2.084 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.247234e-03 2.084 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.247234e-03 2.084 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.247534e-03 2.084 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.247534e-03 2.084 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.601905e-03 2.065 0 0
Death Receptor Signaling R-HSA-73887 8.653907e-03 2.063 1 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.693824e-03 2.061 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.108125e-03 2.041 0 0
Membrane Trafficking R-HSA-199991 9.423424e-03 2.026 0 0
MTOR signalling R-HSA-165159 9.554659e-03 2.020 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.661480e-03 2.015 0 0
Degradation of AXIN R-HSA-4641257 9.661480e-03 2.015 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.661480e-03 2.015 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.754529e-03 2.011 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.754529e-03 2.011 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 9.754529e-03 2.011 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.754529e-03 2.011 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.754529e-03 2.011 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.754529e-03 2.011 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.754529e-03 2.011 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.754529e-03 2.011 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.754529e-03 2.011 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.754529e-03 2.011 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.754529e-03 2.011 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.754529e-03 2.011 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.052242e-02 1.978 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.052242e-02 1.978 0 0
RNA Polymerase II Transcription R-HSA-73857 1.062966e-02 1.973 0 0
DNA Damage Bypass R-HSA-73893 1.063159e-02 1.973 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.175006e-02 1.930 0 0
Ephrin signaling R-HSA-3928664 1.371262e-02 1.863 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.126736e-02 1.948 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.126736e-02 1.948 0 0
Striated Muscle Contraction R-HSA-390522 1.321583e-02 1.879 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.343683e-02 1.872 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.126736e-02 1.948 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.175006e-02 1.930 0 0
Regulation of CDH11 function R-HSA-9762292 1.439820e-02 1.842 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.099818e-02 1.959 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.305276e-02 1.884 0 0
Hedgehog 'off' state R-HSA-5610787 1.127495e-02 1.948 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.175006e-02 1.930 0 0
Josephin domain DUBs R-HSA-5689877 1.439820e-02 1.842 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.371262e-02 1.863 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.126736e-02 1.948 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.305276e-02 1.884 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.083524e-02 1.965 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.221370e-02 1.913 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.101751e-02 1.958 0 0
Hedgehog 'on' state R-HSA-5632684 1.411253e-02 1.850 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.366658e-02 1.864 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.113158e-02 1.953 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.304192e-02 1.885 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.321583e-02 1.879 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.134831e-02 1.945 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.304192e-02 1.885 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.208494e-02 1.918 0 0
Stabilization of p53 R-HSA-69541 1.304192e-02 1.885 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.418814e-02 1.848 0 0
Maturation of protein E R-HSA-9683683 1.175006e-02 1.930 0 0
Maturation of protein E R-HSA-9694493 1.175006e-02 1.930 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.445529e-02 1.840 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.445529e-02 1.840 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.445529e-02 1.840 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.460225e-02 1.836 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.474992e-02 1.831 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.476126e-02 1.831 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.496658e-02 1.825 0 0
Dual Incision in GG-NER R-HSA-5696400 1.540674e-02 1.812 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.544399e-02 1.811 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.544399e-02 1.811 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.544399e-02 1.811 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.554927e-02 1.808 0 0
snRNP Assembly R-HSA-191859 1.636907e-02 1.786 0 0
Metabolism of non-coding RNA R-HSA-194441 1.636907e-02 1.786 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.645325e-02 1.784 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.687752e-02 1.773 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.725091e-02 1.763 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.752373e-02 1.756 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.752373e-02 1.756 0 0
Smooth Muscle Contraction R-HSA-445355 1.752373e-02 1.756 0 0
Signaling by MET R-HSA-6806834 1.758558e-02 1.755 0 0
Signaling by FGFR2 R-HSA-5654738 1.758558e-02 1.755 0 0
Protein folding R-HSA-391251 1.767678e-02 1.753 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.785675e-02 1.748 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.791347e-02 1.747 0 0
HIV Life Cycle R-HSA-162587 1.794396e-02 1.746 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.814228e-02 1.741 0 0
Activation of BH3-only proteins R-HSA-114452 1.814228e-02 1.741 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.848675e-02 1.733 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.848675e-02 1.733 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.848675e-02 1.733 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.848675e-02 1.733 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.848675e-02 1.733 0 0
Translesion synthesis by REV1 R-HSA-110312 1.848675e-02 1.733 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.848675e-02 1.733 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.851260e-02 1.733 0 0
Reproduction R-HSA-1474165 1.879512e-02 1.726 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.913101e-02 1.718 0 0
FOXO-mediated transcription R-HSA-9614085 1.913431e-02 1.718 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.937601e-02 1.713 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.968209e-02 1.706 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.970031e-02 1.706 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.011877e-02 1.696 1 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.023634e-02 1.694 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.023634e-02 1.694 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.023634e-02 1.694 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.023634e-02 1.694 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.023634e-02 1.694 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.023634e-02 1.694 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.023634e-02 1.694 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.040364e-02 1.690 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.052593e-02 1.688 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.052593e-02 1.688 0 0
Co-stimulation by CD28 R-HSA-389356 2.106452e-02 1.676 0 0
EGFR downregulation R-HSA-182971 2.116776e-02 1.674 0 0
Regulation of TP53 Activity R-HSA-5633007 2.180086e-02 1.662 0 0
Signaling by NOTCH3 R-HSA-9012852 2.203398e-02 1.657 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.239749e-02 1.650 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.295096e-02 1.639 0 0
Translesion synthesis by POLI R-HSA-5656121 2.302385e-02 1.638 0 0
ER-Phagosome pathway R-HSA-1236974 2.312604e-02 1.636 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.359902e-02 1.627 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.370029e-02 1.625 0 0
Gap junction trafficking and regulation R-HSA-157858 2.370029e-02 1.625 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.397210e-02 1.620 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.428670e-02 1.615 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.428670e-02 1.615 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.428670e-02 1.615 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.458889e-02 1.609 0 0
Signaling by FGFR1 R-HSA-5654736 2.458889e-02 1.609 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.458889e-02 1.609 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.468987e-02 1.607 0 0
Basigin interactions R-HSA-210991 2.468987e-02 1.607 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.478484e-02 1.606 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.478484e-02 1.606 0 0
Infectious disease R-HSA-5663205 2.522834e-02 1.598 0 0
Signaling by FGFR4 R-HSA-5654743 2.535540e-02 1.596 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.543511e-02 1.595 0 0
Generic Transcription Pathway R-HSA-212436 2.551107e-02 1.593 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.696778e-02 1.569 0 0
TCR signaling R-HSA-202403 2.789632e-02 1.554 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.797722e-02 1.553 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.797722e-02 1.553 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.813037e-02 1.551 0 0
Regulation of gap junction activity R-HSA-191650 2.813037e-02 1.551 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.813037e-02 1.551 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.813037e-02 1.551 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.813037e-02 1.551 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.813037e-02 1.551 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.813037e-02 1.551 0 0
Translesion synthesis by POLK R-HSA-5655862 2.825394e-02 1.549 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.825394e-02 1.549 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.825394e-02 1.549 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.827675e-02 1.549 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.827675e-02 1.549 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.827675e-02 1.549 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.858653e-02 1.544 0 0
Cyclin D associated events in G1 R-HSA-69231 2.858653e-02 1.544 0 0
G1 Phase R-HSA-69236 2.858653e-02 1.544 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.858653e-02 1.544 0 0
RMTs methylate histone arginines R-HSA-3214858 2.858653e-02 1.544 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.921476e-02 1.534 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.921476e-02 1.534 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.921476e-02 1.534 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.939854e-02 1.532 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.939854e-02 1.532 0 0
Hemostasis R-HSA-109582 2.962928e-02 1.528 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.968621e-02 1.527 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 4.244017e-02 1.372 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 4.244017e-02 1.372 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 4.244017e-02 1.372 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.132135e-02 1.384 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.132135e-02 1.384 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.132135e-02 1.384 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.273564e-02 1.485 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.273564e-02 1.485 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 3.141162e-02 1.503 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 3.141162e-02 1.503 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.141162e-02 1.503 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.141162e-02 1.503 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.141162e-02 1.503 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.141162e-02 1.503 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.141162e-02 1.503 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.905045e-02 1.408 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.905045e-02 1.408 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.092480e-02 1.388 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.387733e-02 1.470 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.902037e-02 1.409 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.239580e-02 1.490 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.210283e-02 1.493 0 0
Nucleotide Excision Repair R-HSA-5696398 3.320583e-02 1.479 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.466009e-02 1.350 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.582253e-02 1.446 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.691276e-02 1.433 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.269908e-02 1.370 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.141162e-02 1.503 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.691276e-02 1.433 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.269908e-02 1.370 0 0
tRNA processing in the nucleus R-HSA-6784531 4.467798e-02 1.350 0 0
MAP kinase activation R-HSA-450294 4.072200e-02 1.390 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.056702e-02 1.515 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.273564e-02 1.485 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.269908e-02 1.370 0 0
Unwinding of DNA R-HSA-176974 4.269908e-02 1.370 0 0
HCMV Late Events R-HSA-9610379 4.545417e-02 1.342 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.467786e-02 1.460 0 0
Signaling by FGFR R-HSA-190236 3.157167e-02 1.501 0 0
Signaling by FGFR3 R-HSA-5654741 3.210283e-02 1.493 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.691276e-02 1.433 0 0
Platelet degranulation R-HSA-114608 3.962262e-02 1.402 0 0
Growth hormone receptor signaling R-HSA-982772 4.055020e-02 1.392 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.092480e-02 1.388 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.887341e-02 1.410 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.141162e-02 1.503 1 1
Modulation by Mtb of host immune system R-HSA-9637628 3.273564e-02 1.485 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.673277e-02 1.330 0 0
Neurodegenerative Diseases R-HSA-8863678 4.703408e-02 1.328 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.703408e-02 1.328 0 0
FLT3 signaling in disease R-HSA-9682385 4.719608e-02 1.326 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.772740e-02 1.321 0 0
Rap1 signalling R-HSA-392517 4.841522e-02 1.315 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.841522e-02 1.315 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.861511e-02 1.313 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.872228e-02 1.312 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.923380e-02 1.308 0 0
Ion homeostasis R-HSA-5578775 4.927411e-02 1.307 0 0
Rab regulation of trafficking R-HSA-9007101 5.176636e-02 1.286 0 0
Cilium Assembly R-HSA-5617833 5.210855e-02 1.283 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.232194e-02 1.281 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.232194e-02 1.281 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.241742e-02 1.281 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.241742e-02 1.281 0 0
Signaling by TGFB family members R-HSA-9006936 5.354684e-02 1.271 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.388083e-02 1.269 0 0
TBC/RABGAPs R-HSA-8854214 5.404936e-02 1.267 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.404936e-02 1.267 0 0
PI3K/AKT activation R-HSA-198203 5.418449e-02 1.266 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.418449e-02 1.266 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.418449e-02 1.266 0 0
Signal attenuation R-HSA-74749 5.418449e-02 1.266 0 0
Pexophagy R-HSA-9664873 5.418449e-02 1.266 0 0
Signaling by Hedgehog R-HSA-5358351 5.472493e-02 1.262 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.669736e-02 1.246 0 0
Signaling by NODAL R-HSA-1181150 5.669736e-02 1.246 0 0
Glycogen synthesis R-HSA-3322077 5.669736e-02 1.246 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.708485e-02 1.243 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.708485e-02 1.243 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.745555e-02 1.241 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.745555e-02 1.241 0 0
DCC mediated attractive signaling R-HSA-418885 5.745555e-02 1.241 0 0
p75NTR signals via NF-kB R-HSA-193639 5.745555e-02 1.241 1 0
DNA strand elongation R-HSA-69190 5.748165e-02 1.240 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.976502e-02 1.224 0 0
Proteasome assembly R-HSA-9907900 5.987000e-02 1.223 0 0
Gap junction trafficking R-HSA-190828 5.987000e-02 1.223 0 0
Netrin-1 signaling R-HSA-373752 5.987000e-02 1.223 0 0
Myogenesis R-HSA-525793 6.189008e-02 1.208 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.468271e-02 1.189 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.554683e-02 1.183 0 0
ERK/MAPK targets R-HSA-198753 6.577891e-02 1.182 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.577891e-02 1.182 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.590731e-02 1.181 0 0
Somitogenesis R-HSA-9824272 6.608333e-02 1.180 0 0
Signaling by APC mutants R-HSA-4839744 6.717215e-02 1.173 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.717215e-02 1.173 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.717215e-02 1.173 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.717215e-02 1.173 0 0
Suppression of apoptosis R-HSA-9635465 6.717215e-02 1.173 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.823543e-02 1.166 0 0
Cellular response to chemical stress R-HSA-9711123 6.896059e-02 1.161 1 0
Cristae formation R-HSA-8949613 7.027850e-02 1.153 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.027850e-02 1.153 0 0
mRNA Editing: A to I Conversion R-HSA-75064 7.037342e-02 1.153 0 0
C6 deamination of adenosine R-HSA-75102 7.037342e-02 1.153 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.167935e-02 1.145 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.241874e-02 1.140 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.305085e-02 1.136 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.526001e-02 1.123 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.526001e-02 1.123 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.526001e-02 1.123 0 0
Nef and signal transduction R-HSA-164944 7.526001e-02 1.123 0 0
Signaling by LTK in cancer R-HSA-9842640 7.526001e-02 1.123 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.566068e-02 1.121 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.566068e-02 1.121 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.566068e-02 1.121 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.566068e-02 1.121 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.566068e-02 1.121 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.566068e-02 1.121 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.624267e-02 1.118 0 0
Immune System R-HSA-168256 7.628586e-02 1.118 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.005563e-02 1.097 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.005563e-02 1.097 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.065433e-02 1.093 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.065433e-02 1.093 0 0
Gap junction assembly R-HSA-190861 8.069223e-02 1.093 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.161836e-02 1.088 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.161836e-02 1.088 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.161836e-02 1.088 0 0
Signaling by AXIN mutants R-HSA-4839735 8.161836e-02 1.088 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.161836e-02 1.088 0 0
NF-kB is activated and signals survival R-HSA-209560 8.161836e-02 1.088 0 0
Activation of RAC1 R-HSA-428540 8.161836e-02 1.088 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.500924e-02 1.071 0 0
Interleukin-17 signaling R-HSA-448424 8.613710e-02 1.065 0 0
FGFR2 alternative splicing R-HSA-6803529 8.633682e-02 1.064 0 0
Circadian clock R-HSA-9909396 8.790646e-02 1.056 0 0
Translation of Structural Proteins R-HSA-9683701 8.871866e-02 1.052 0 0
Late endosomal microautophagy R-HSA-9615710 8.898493e-02 1.051 0 0
Platelet calcium homeostasis R-HSA-418360 8.898493e-02 1.051 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.898493e-02 1.051 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.898493e-02 1.051 0 0
Oncogene Induced Senescence R-HSA-2559585 8.950280e-02 1.048 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.018051e-02 1.045 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 9.221000e-02 1.035 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.289364e-02 1.032 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.289364e-02 1.032 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.289364e-02 1.032 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.289364e-02 1.032 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.024242e-01 0.990 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.024242e-01 0.990 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.024242e-01 0.990 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.024242e-01 0.990 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.024242e-01 0.990 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.024242e-01 0.990 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.024242e-01 0.990 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.024242e-01 0.990 0 0
MET interacts with TNS proteins R-HSA-8875513 1.026308e-01 0.989 0 0
Axonal growth stimulation R-HSA-209563 1.026308e-01 0.989 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.026308e-01 0.989 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.026308e-01 0.989 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.026308e-01 0.989 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.380346e-01 0.860 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.380346e-01 0.860 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.380346e-01 0.860 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.380346e-01 0.860 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.380346e-01 0.860 0 0
IFNG signaling activates MAPKs R-HSA-9732724 9.564036e-02 1.019 0 0
Recycling of eIF2:GDP R-HSA-72731 9.564036e-02 1.019 0 0
Disinhibition of SNARE formation R-HSA-114516 9.564036e-02 1.019 0 0
Co-inhibition by BTLA R-HSA-9927353 1.756027e-01 0.755 0 0
IRS activation R-HSA-74713 1.756027e-01 0.755 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.756027e-01 0.755 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.756027e-01 0.755 0 0
RSK activation R-HSA-444257 1.179901e-01 0.928 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.179901e-01 0.928 0 0
Formation of annular gap junctions R-HSA-196025 1.179901e-01 0.928 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 9.745887e-02 1.011 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.420571e-01 0.848 0 0
Gap junction degradation R-HSA-190873 1.420571e-01 0.848 0 0
WNT mediated activation of DVL R-HSA-201688 1.420571e-01 0.848 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.420571e-01 0.848 0 0
Calcineurin activates NFAT R-HSA-2025928 1.420571e-01 0.848 0 0
ALK mutants bind TKIs R-HSA-9700645 1.420571e-01 0.848 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.146124e-01 0.941 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.675827e-01 0.776 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.675827e-01 0.776 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.329838e-01 0.876 0 0
GAB1 signalosome R-HSA-180292 1.067169e-01 0.972 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.067169e-01 0.972 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.214836e-01 0.915 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.729500e-01 0.762 0 0
MET promotes cell motility R-HSA-8875878 1.191105e-01 0.924 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.245679e-01 0.905 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.245679e-01 0.905 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.245679e-01 0.905 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.245679e-01 0.905 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.245679e-01 0.905 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.213834e-01 0.916 0 0
Dual incision in TC-NER R-HSA-6782135 1.826910e-01 0.738 0 0
Signaling by ERBB4 R-HSA-1236394 1.831535e-01 0.737 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.366529e-01 0.864 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.536426e-01 0.813 0 0
Signaling by NOTCH1 R-HSA-1980143 1.292983e-01 0.888 0 0
Formation of definitive endoderm R-HSA-9823730 1.371443e-01 0.863 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.598653e-01 0.796 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.465756e-01 0.834 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.675827e-01 0.776 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.756027e-01 0.755 0 0
Formation of apoptosome R-HSA-111458 1.675827e-01 0.776 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.729500e-01 0.762 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.214836e-01 0.915 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.510037e-01 0.821 0 0
GPVI-mediated activation cascade R-HSA-114604 1.879001e-01 0.726 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.380346e-01 0.860 0 0
Adrenoceptors R-HSA-390696 1.179901e-01 0.928 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 9.745887e-02 1.011 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.420571e-01 0.848 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.146124e-01 0.941 0 0
Formation of axial mesoderm R-HSA-9796292 1.146124e-01 0.941 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.366529e-01 0.864 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.815836e-01 0.741 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.366529e-01 0.864 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.642885e-01 0.784 0 0
Frs2-mediated activation R-HSA-170968 1.146124e-01 0.941 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.190135e-01 0.924 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.190135e-01 0.924 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.756027e-01 0.755 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.756027e-01 0.755 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.179901e-01 0.928 0 0
Downstream TCR signaling R-HSA-202424 1.241821e-01 0.906 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.507377e-01 0.822 0 0
Signaling by SCF-KIT R-HSA-1433557 1.062232e-01 0.974 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.214836e-01 0.915 0 0
Prolonged ERK activation events R-HSA-169893 1.729500e-01 0.762 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.190766e-01 0.924 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.335302e-01 0.874 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.420571e-01 0.848 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.329838e-01 0.876 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.623172e-01 0.790 0 0
HDMs demethylate histones R-HSA-3214842 1.229796e-01 0.910 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.102272e-01 0.958 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.756027e-01 0.755 0 0
Platelet sensitization by LDL R-HSA-432142 1.067169e-01 0.972 0 0
The NLRP3 inflammasome R-HSA-844456 1.214836e-01 0.915 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.580396e-01 0.801 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.466228e-01 0.834 0 0
Ca-dependent events R-HSA-111996 9.724268e-02 1.012 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.612998e-01 0.792 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.018149e-01 0.992 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.380346e-01 0.860 0 0
Reelin signalling pathway R-HSA-8866376 1.756027e-01 0.755 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.756027e-01 0.755 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.335302e-01 0.874 0 0
Adaptive Immune System R-HSA-1280218 1.206763e-01 0.918 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.865984e-01 0.729 0 0
Calmodulin induced events R-HSA-111933 1.879001e-01 0.726 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.428312e-01 0.845 0 0
DAG and IP3 signaling R-HSA-1489509 1.255306e-01 0.901 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.381800e-01 0.860 0 0
CaM pathway R-HSA-111997 1.879001e-01 0.726 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.392119e-01 0.856 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.392119e-01 0.856 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.392119e-01 0.856 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.329838e-01 0.876 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.691065e-01 0.772 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.023164e-01 0.990 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.624193e-01 0.789 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.976821e-02 1.001 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 9.564036e-02 1.019 0 0
Signaling by Activin R-HSA-1502540 1.524674e-01 0.817 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.339061e-01 0.873 0 0
Signaling by NTRKs R-HSA-166520 9.724779e-02 1.012 0 0
Maturation of spike protein R-HSA-9683686 1.675827e-01 0.776 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.659944e-01 0.780 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.676050e-01 0.776 0 0
Disease R-HSA-1643685 1.558990e-01 0.807 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.100173e-01 0.959 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.071892e-01 0.970 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.536426e-01 0.813 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.217706e-01 0.914 0 0
Glycolysis R-HSA-70171 1.002169e-01 0.999 0 0
RET signaling R-HSA-8853659 1.879001e-01 0.726 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.536426e-01 0.813 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.300093e-01 0.886 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.536426e-01 0.813 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 1.230421e-01 0.910 0 0
MHC class II antigen presentation R-HSA-2132295 1.659988e-01 0.780 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.745887e-02 1.011 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.745887e-02 1.011 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.329838e-01 0.876 0 0
Assembly Of The HIV Virion R-HSA-175474 1.709165e-01 0.767 0 0
ABC-family proteins mediated transport R-HSA-382556 1.544009e-01 0.811 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.146124e-01 0.941 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.329838e-01 0.876 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.709165e-01 0.767 0 0
Cellular response to hypoxia R-HSA-1234174 1.726888e-01 0.763 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.729500e-01 0.762 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.067169e-01 0.972 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.549909e-01 0.810 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.339061e-01 0.873 0 0
Regulation of BACH1 activity R-HSA-9708530 1.729500e-01 0.762 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.295436e-01 0.888 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.756027e-01 0.755 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.891788e-01 0.723 0 0
G-protein mediated events R-HSA-112040 1.941269e-01 0.712 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.943099e-01 0.712 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.943099e-01 0.712 0 0
Disorders of Developmental Biology R-HSA-9675151 1.943132e-01 0.711 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.943132e-01 0.711 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.943132e-01 0.711 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.943632e-01 0.711 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.943632e-01 0.711 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 1.943632e-01 0.711 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.943632e-01 0.711 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.943632e-01 0.711 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.943632e-01 0.711 0 0
Hereditary fructose intolerance R-HSA-5657560 1.943632e-01 0.711 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.943632e-01 0.711 0 0
Inhibition of PKR R-HSA-169131 1.943632e-01 0.711 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.977273e-01 0.704 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.977273e-01 0.704 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.022201e-01 0.694 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.061069e-01 0.686 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.075224e-01 0.683 0 0
Syndecan interactions R-HSA-3000170 2.075224e-01 0.683 0 0
IRE1alpha activates chaperones R-HSA-381070 2.101636e-01 0.677 0 0
Trafficking of AMPA receptors R-HSA-399719 2.143789e-01 0.669 0 0
Budding and maturation of HIV virion R-HSA-162588 2.143789e-01 0.669 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.143789e-01 0.669 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.145209e-01 0.669 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.145209e-01 0.669 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.145209e-01 0.669 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.145209e-01 0.669 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.145209e-01 0.669 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.145209e-01 0.669 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.145209e-01 0.669 0 0
Translation of Structural Proteins R-HSA-9694635 2.147770e-01 0.668 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.164361e-01 0.665 0 0
Glycogen storage diseases R-HSA-3229121 2.164361e-01 0.665 0 0
PLC beta mediated events R-HSA-112043 2.181749e-01 0.661 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.190767e-01 0.659 0 0
ERKs are inactivated R-HSA-202670 2.219887e-01 0.654 0 0
Integration of provirus R-HSA-162592 2.219887e-01 0.654 0 0
ABC transporter disorders R-HSA-5619084 2.258029e-01 0.646 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.288997e-01 0.640 0 0
G0 and Early G1 R-HSA-1538133 2.314898e-01 0.635 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.314898e-01 0.635 0 0
Signaling by WNT in cancer R-HSA-4791275 2.314898e-01 0.635 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.333019e-01 0.632 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.337066e-01 0.631 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.339358e-01 0.631 0 0
Interleukin-1 signaling R-HSA-9020702 2.366807e-01 0.626 0 0
Mismatch Repair R-HSA-5358508 2.391973e-01 0.621 0 0
Apoptotic factor-mediated response R-HSA-111471 2.391973e-01 0.621 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.391973e-01 0.621 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.418088e-01 0.617 0 0
G alpha (z) signalling events R-HSA-418597 2.458729e-01 0.609 0 0
Tight junction interactions R-HSA-420029 2.463961e-01 0.608 1 1
VEGFR2 mediated cell proliferation R-HSA-5218921 2.463961e-01 0.608 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.490103e-01 0.604 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.491911e-01 0.603 0 0
HIV Transcription Elongation R-HSA-167169 2.491911e-01 0.603 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.491911e-01 0.603 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.503809e-01 0.601 0 0
Pervasive developmental disorders R-HSA-9005895 2.503809e-01 0.601 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.503809e-01 0.601 0 0
Disorders of Nervous System Development R-HSA-9697154 2.503809e-01 0.601 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.503809e-01 0.601 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.503809e-01 0.601 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.523874e-01 0.598 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.541191e-01 0.595 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.541191e-01 0.595 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.541191e-01 0.595 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.541191e-01 0.595 0 0
CREB phosphorylation R-HSA-199920 2.541191e-01 0.595 0 0
Glucose metabolism R-HSA-70326 2.569873e-01 0.590 0 0
Vesicle-mediated transport R-HSA-5653656 2.571720e-01 0.590 0 0
TNF signaling R-HSA-75893 2.596794e-01 0.586 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.613391e-01 0.583 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.613391e-01 0.583 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.613391e-01 0.583 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.624766e-01 0.581 0 0
GPER1 signaling R-HSA-9634597 2.628477e-01 0.580 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.664995e-01 0.574 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.664995e-01 0.574 0 0
Opioid Signalling R-HSA-111885 2.672882e-01 0.573 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.672882e-01 0.573 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.764064e-01 0.558 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.764064e-01 0.558 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.768896e-01 0.558 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.768896e-01 0.558 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.768896e-01 0.558 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.768896e-01 0.558 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.768896e-01 0.558 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.768896e-01 0.558 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.768896e-01 0.558 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.768896e-01 0.558 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.768896e-01 0.558 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.768896e-01 0.558 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.768896e-01 0.558 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.768896e-01 0.558 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.768896e-01 0.558 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.768896e-01 0.558 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.768896e-01 0.558 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.772594e-01 0.557 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.792625e-01 0.554 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.792625e-01 0.554 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.792625e-01 0.554 0 0
Potential therapeutics for SARS R-HSA-9679191 2.808144e-01 0.552 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.850763e-01 0.545 0 0
Signaling by NOTCH2 R-HSA-1980145 2.850763e-01 0.545 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.861565e-01 0.543 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.861565e-01 0.543 0 0
Protein hydroxylation R-HSA-9629569 2.861565e-01 0.543 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.861565e-01 0.543 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.869487e-01 0.542 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.869487e-01 0.542 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.869487e-01 0.542 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.869487e-01 0.542 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.869487e-01 0.542 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.938500e-01 0.532 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 2.938500e-01 0.532 0 0
SOS-mediated signalling R-HSA-112412 2.938500e-01 0.532 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.938500e-01 0.532 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.959827e-01 0.529 0 0
Platelet homeostasis R-HSA-418346 2.991941e-01 0.524 0 0
Signalling to ERKs R-HSA-187687 3.035196e-01 0.518 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.064313e-01 0.514 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.064313e-01 0.514 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.076709e-01 0.512 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.076709e-01 0.512 0 0
HIV elongation arrest and recovery R-HSA-167287 3.076709e-01 0.512 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.076709e-01 0.512 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.076709e-01 0.512 0 0
Inflammasomes R-HSA-622312 3.076709e-01 0.512 0 0
Signal regulatory protein family interactions R-HSA-391160 3.084265e-01 0.511 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.097836e-01 0.509 0 0
Lagging Strand Synthesis R-HSA-69186 3.101235e-01 0.508 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.101235e-01 0.508 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 3.133220e-01 0.504 0 0
RUNX2 regulates bone development R-HSA-8941326 3.221686e-01 0.492 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.236038e-01 0.490 0 0
Signaling by Erythropoietin R-HSA-9006335 3.285948e-01 0.483 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.285948e-01 0.483 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.285948e-01 0.483 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.332713e-01 0.477 0 0
Type I hemidesmosome assembly R-HSA-446107 3.332713e-01 0.477 0 0
phospho-PLA2 pathway R-HSA-111995 3.332713e-01 0.477 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.332713e-01 0.477 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.332713e-01 0.477 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.332713e-01 0.477 0 0
Sodium/Proton exchangers R-HSA-425986 3.332713e-01 0.477 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.376833e-01 0.471 0 0
Protein methylation R-HSA-8876725 3.376833e-01 0.471 0 0
Sensory processing of sound R-HSA-9659379 3.422461e-01 0.466 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.430216e-01 0.465 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.496515e-01 0.456 0 0
DAP12 signaling R-HSA-2424491 3.496515e-01 0.456 0 0
Interleukin-37 signaling R-HSA-9008059 3.496515e-01 0.456 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.498491e-01 0.456 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.509667e-01 0.455 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.509667e-01 0.455 0 0
Potassium transport channels R-HSA-1296067 3.509667e-01 0.455 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.509667e-01 0.455 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.509667e-01 0.455 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.509667e-01 0.455 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.509667e-01 0.455 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.584911e-01 0.446 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.584911e-01 0.446 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.584911e-01 0.446 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.616529e-01 0.442 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.657286e-01 0.437 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.666146e-01 0.436 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.668618e-01 0.435 0 0
Phosphorylation of the APC/C R-HSA-176412 3.668618e-01 0.435 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.668618e-01 0.435 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.671601e-01 0.435 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.671601e-01 0.435 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.671601e-01 0.435 0 0
Downstream signal transduction R-HSA-186763 3.707743e-01 0.431 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 3.720297e-01 0.429 0 0
mRNA Editing R-HSA-75072 3.720297e-01 0.429 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.720297e-01 0.429 0 0
ARMS-mediated activation R-HSA-170984 3.720297e-01 0.429 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.720297e-01 0.429 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.720297e-01 0.429 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.720297e-01 0.429 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.720297e-01 0.429 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.720297e-01 0.429 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.720297e-01 0.429 0 0
Ion transport by P-type ATPases R-HSA-936837 3.766945e-01 0.424 0 0
Signaling by ALK R-HSA-201556 3.788561e-01 0.422 0 0
Interleukin-1 family signaling R-HSA-446652 3.818164e-01 0.418 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.826929e-01 0.417 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.826929e-01 0.417 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.845254e-01 0.415 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.845254e-01 0.415 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.918999e-01 0.407 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.958089e-01 0.403 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.958089e-01 0.403 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.958089e-01 0.403 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.958089e-01 0.403 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.958089e-01 0.403 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.978407e-01 0.400 0 0
Glycogen metabolism R-HSA-8982491 3.978407e-01 0.400 0 0
Intraflagellar transport R-HSA-5620924 4.019100e-01 0.396 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.067854e-01 0.391 0 0
Deadenylation of mRNA R-HSA-429947 4.067854e-01 0.391 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.067854e-01 0.391 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.084325e-01 0.389 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.098476e-01 0.387 0 0
Binding and entry of HIV virion R-HSA-173107 4.098476e-01 0.387 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.098476e-01 0.387 0 0
2-LTR circle formation R-HSA-164843 4.098476e-01 0.387 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.098476e-01 0.387 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.098476e-01 0.387 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.098476e-01 0.387 0 0
Signaling by Leptin R-HSA-2586552 4.098476e-01 0.387 0 0
G-protein beta:gamma signalling R-HSA-397795 4.129680e-01 0.384 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.129680e-01 0.384 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.129680e-01 0.384 0 0
Maturation of spike protein R-HSA-9694548 4.167949e-01 0.380 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.174591e-01 0.379 0 0
PLC-gamma1 signalling R-HSA-167021 4.174591e-01 0.379 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.174591e-01 0.379 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.174591e-01 0.379 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.174591e-01 0.379 0 0
Invadopodia formation R-HSA-8941237 4.174591e-01 0.379 0 0
MET activates PTPN11 R-HSA-8865999 4.174591e-01 0.379 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.174591e-01 0.379 0 0
Intracellular oxygen transport R-HSA-8981607 4.174591e-01 0.379 0 0
Cardiac conduction R-HSA-5576891 4.224761e-01 0.374 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.232613e-01 0.373 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.243900e-01 0.372 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.243900e-01 0.372 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.243900e-01 0.372 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.296222e-01 0.367 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.306862e-01 0.366 0 0
TGFBR3 expression R-HSA-9839394 4.306862e-01 0.366 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.356766e-01 0.361 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.356766e-01 0.361 0 0
Disorders of transmembrane transporters R-HSA-5619115 4.396945e-01 0.357 0 0
Bicarbonate transporters R-HSA-425381 4.465110e-01 0.350 0 0
Transport of RCbl within the body R-HSA-9758890 4.465110e-01 0.350 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.465110e-01 0.350 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.491718e-01 0.348 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.524873e-01 0.344 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.524873e-01 0.344 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.524873e-01 0.344 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.543203e-01 0.343 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.543203e-01 0.343 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.544461e-01 0.343 0 0
Signal amplification R-HSA-392518 4.547091e-01 0.342 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.752802e-01 0.323 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.752802e-01 0.323 0 0
HCN channels R-HSA-1296061 4.771430e-01 0.321 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.771430e-01 0.321 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.771430e-01 0.321 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.771430e-01 0.321 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.771430e-01 0.321 0 0
Alanine metabolism R-HSA-8964540 4.771430e-01 0.321 0 0
Dopamine receptors R-HSA-390651 4.771430e-01 0.321 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.771430e-01 0.321 0 0
NADE modulates death signalling R-HSA-205025 4.771430e-01 0.321 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.776200e-01 0.321 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.776200e-01 0.321 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 4.799998e-01 0.319 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.799998e-01 0.319 0 0
Other interleukin signaling R-HSA-449836 4.799998e-01 0.319 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.799998e-01 0.319 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.818597e-01 0.317 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.818597e-01 0.317 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.818597e-01 0.317 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.818597e-01 0.317 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.818597e-01 0.317 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.818597e-01 0.317 0 0
G1/S-Specific Transcription R-HSA-69205 4.955901e-01 0.305 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.976106e-01 0.303 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.997080e-01 0.301 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.068420e-01 0.295 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 5.068420e-01 0.295 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.114870e-01 0.291 0 0
Leading Strand Synthesis R-HSA-69109 5.157782e-01 0.288 0 0
Polymerase switching R-HSA-69091 5.157782e-01 0.288 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.157782e-01 0.288 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.157782e-01 0.288 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.157782e-01 0.288 0 0
Signaling by LTK R-HSA-9842663 5.157782e-01 0.288 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.157782e-01 0.288 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.157782e-01 0.288 0 0
Regulation of IFNG signaling R-HSA-877312 5.157782e-01 0.288 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.157782e-01 0.288 0 0
OAS antiviral response R-HSA-8983711 5.157782e-01 0.288 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.178890e-01 0.286 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.229806e-01 0.282 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.276879e-01 0.278 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.276879e-01 0.278 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.276879e-01 0.278 0 0
Interferon alpha/beta signaling R-HSA-909733 5.294773e-01 0.276 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.307151e-01 0.275 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.307151e-01 0.275 0 0
Activation of AKT2 R-HSA-165158 5.307151e-01 0.275 0 0
PTK6 Down-Regulation R-HSA-8849472 5.307151e-01 0.275 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.307151e-01 0.275 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.307151e-01 0.275 0 0
Suppression of autophagy R-HSA-9636569 5.307151e-01 0.275 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.307151e-01 0.275 0 0
NrCAM interactions R-HSA-447038 5.307151e-01 0.275 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.329429e-01 0.273 0 0
G-protein activation R-HSA-202040 5.329429e-01 0.273 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.329429e-01 0.273 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.352657e-01 0.271 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.352657e-01 0.271 0 0
Iron uptake and transport R-HSA-917937 5.405229e-01 0.267 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.449412e-01 0.264 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.453822e-01 0.263 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.481886e-01 0.261 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.481886e-01 0.261 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.481886e-01 0.261 0 0
Processing of SMDT1 R-HSA-8949664 5.481886e-01 0.261 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.481886e-01 0.261 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.481886e-01 0.261 0 0
Maturation of nucleoprotein R-HSA-9683610 5.481886e-01 0.261 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.545607e-01 0.256 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.545607e-01 0.256 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.582448e-01 0.253 0 0
Gluconeogenesis R-HSA-70263 5.627759e-01 0.250 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.663659e-01 0.247 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.685347e-01 0.245 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.734531e-01 0.242 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.734531e-01 0.242 0 0
Generation of second messenger molecules R-HSA-202433 5.734531e-01 0.242 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.788011e-01 0.237 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.788011e-01 0.237 0 0
Plus-strand DNA synthesis R-HSA-164525 5.788011e-01 0.237 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.788011e-01 0.237 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.788011e-01 0.237 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.788011e-01 0.237 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.788011e-01 0.237 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.788011e-01 0.237 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.788011e-01 0.237 0 0
Signaling by MAPK mutants R-HSA-9652817 5.788011e-01 0.237 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.788011e-01 0.237 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.788011e-01 0.237 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.788011e-01 0.237 0 0
PKB-mediated events R-HSA-109703 5.788011e-01 0.237 0 0
PDE3B signalling R-HSA-165160 5.788011e-01 0.237 0 0
Phosphorylation of Emi1 R-HSA-176417 5.788011e-01 0.237 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.788011e-01 0.237 0 0
Synthesis of PS R-HSA-1483101 5.788011e-01 0.237 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.788011e-01 0.237 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.788011e-01 0.237 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.788011e-01 0.237 0 0
Removal of the Flap Intermediate R-HSA-69166 5.790438e-01 0.237 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.790438e-01 0.237 0 0
Inositol phosphate metabolism R-HSA-1483249 5.805622e-01 0.236 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.811817e-01 0.236 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.827020e-01 0.235 0 0
Notch-HLH transcription pathway R-HSA-350054 5.827020e-01 0.235 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.827020e-01 0.235 0 0
Signaling by KIT in disease R-HSA-9669938 5.827020e-01 0.235 0 0
LDL clearance R-HSA-8964038 5.827020e-01 0.235 0 0
Extension of Telomeres R-HSA-180786 5.857232e-01 0.232 0 0
Peroxisomal protein import R-HSA-9033241 5.857232e-01 0.232 0 0
Regulation of beta-cell development R-HSA-186712 5.857232e-01 0.232 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.872209e-01 0.231 0 0
Pyruvate metabolism R-HSA-70268 5.883026e-01 0.230 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.919170e-01 0.228 0 0
RAB geranylgeranylation R-HSA-8873719 6.011130e-01 0.221 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.011130e-01 0.221 0 0
Metabolism of polyamines R-HSA-351202 6.011130e-01 0.221 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.074777e-01 0.216 0 0
Erythropoietin activates RAS R-HSA-9027284 6.083223e-01 0.216 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.083223e-01 0.216 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.083223e-01 0.216 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.083223e-01 0.216 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.083223e-01 0.216 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.083223e-01 0.216 0 0
p38MAPK events R-HSA-171007 6.083223e-01 0.216 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.083223e-01 0.216 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.105396e-01 0.214 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.219623e-01 0.206 0 0
Uncoating of the HIV Virion R-HSA-162585 6.219623e-01 0.206 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.219623e-01 0.206 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.219623e-01 0.206 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.219623e-01 0.206 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.219623e-01 0.206 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.219623e-01 0.206 0 0
Lactose synthesis R-HSA-5653890 6.219623e-01 0.206 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.219623e-01 0.206 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.219623e-01 0.206 0 0
NADPH regeneration R-HSA-389542 6.219623e-01 0.206 0 0
HDL clearance R-HSA-8964011 6.219623e-01 0.206 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.271136e-01 0.203 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.271136e-01 0.203 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.271136e-01 0.203 0 0
Activation of GABAB receptors R-HSA-991365 6.274732e-01 0.202 0 0
GABA B receptor activation R-HSA-977444 6.274732e-01 0.202 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.289548e-01 0.201 0 0
Gastrulation R-HSA-9758941 6.298636e-01 0.201 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.360232e-01 0.197 0 0
Killing mechanisms R-HSA-9664420 6.360232e-01 0.197 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.360232e-01 0.197 0 0
Activation of SMO R-HSA-5635838 6.360232e-01 0.197 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.360232e-01 0.197 0 0
Virus Assembly and Release R-HSA-168268 6.360232e-01 0.197 0 0
Developmental Cell Lineages R-HSA-9734767 6.382955e-01 0.195 0 0
Stimuli-sensing channels R-HSA-2672351 6.441802e-01 0.191 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.461109e-01 0.190 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.461109e-01 0.190 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.507103e-01 0.187 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.507103e-01 0.187 0 0
G protein gated Potassium channels R-HSA-1296059 6.507103e-01 0.187 0 0
Interleukin-7 signaling R-HSA-1266695 6.507103e-01 0.187 0 0
Ion channel transport R-HSA-983712 6.519021e-01 0.186 0 0
Insulin receptor signalling cascade R-HSA-74751 6.595270e-01 0.181 0 0
Signaling by FGFR in disease R-HSA-1226099 6.600829e-01 0.180 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.607031e-01 0.180 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.607031e-01 0.180 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.607031e-01 0.180 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.607031e-01 0.180 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.607031e-01 0.180 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.607031e-01 0.180 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.607031e-01 0.180 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.607031e-01 0.180 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.607031e-01 0.180 0 0
VLDL clearance R-HSA-8964046 6.607031e-01 0.180 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.607031e-01 0.180 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.607031e-01 0.180 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.607031e-01 0.180 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.607031e-01 0.180 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.607031e-01 0.180 0 0
Netrin mediated repulsion signals R-HSA-418886 6.607031e-01 0.180 0 0
CHL1 interactions R-HSA-447041 6.607031e-01 0.180 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.607031e-01 0.180 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.607031e-01 0.180 0 0
DAP12 interactions R-HSA-2172127 6.610900e-01 0.180 0 0
Amine ligand-binding receptors R-HSA-375280 6.610900e-01 0.180 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.621623e-01 0.179 0 0
Phase 2 - plateau phase R-HSA-5576893 6.621623e-01 0.179 0 0
Fibronectin matrix formation R-HSA-1566977 6.621623e-01 0.179 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.621623e-01 0.179 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.621623e-01 0.179 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.621623e-01 0.179 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.621623e-01 0.179 0 0
Passive transport by Aquaporins R-HSA-432047 6.621623e-01 0.179 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.621623e-01 0.179 0 0
PERK regulates gene expression R-HSA-381042 6.644567e-01 0.178 0 0
Protein localization R-HSA-9609507 6.670714e-01 0.176 0 0
Toll-like Receptor Cascades R-HSA-168898 6.684517e-01 0.175 0 0
MET activates PTK2 signaling R-HSA-8874081 6.715388e-01 0.173 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.715388e-01 0.173 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.733390e-01 0.172 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.771412e-01 0.169 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.771412e-01 0.169 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.821423e-01 0.166 0 0
RNA Polymerase III Transcription R-HSA-74158 6.821423e-01 0.166 0 0
Neddylation R-HSA-8951664 6.834835e-01 0.165 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.867688e-01 0.163 0 0
Specification of primordial germ cells R-HSA-9827857 6.867688e-01 0.163 0 0
Maturation of hRSV A proteins R-HSA-9828806 6.914395e-01 0.160 0 0
Diseases of DNA repair R-HSA-9675135 6.926773e-01 0.159 0 0
Signaling by TGFBR3 R-HSA-9839373 6.926773e-01 0.159 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.954757e-01 0.158 0 0
Minus-strand DNA synthesis R-HSA-164516 6.954757e-01 0.158 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.954757e-01 0.158 0 0
MET receptor recycling R-HSA-8875656 6.954757e-01 0.158 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.954757e-01 0.158 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.954757e-01 0.158 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.954757e-01 0.158 0 0
Co-stimulation by ICOS R-HSA-9927354 6.954757e-01 0.158 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.954757e-01 0.158 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.954757e-01 0.158 0 0
SLC transporter disorders R-HSA-5619102 7.035316e-01 0.153 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.098822e-01 0.149 0 0
Polo-like kinase mediated events R-HSA-156711 7.098822e-01 0.149 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.098822e-01 0.149 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.098822e-01 0.149 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.098822e-01 0.149 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.098822e-01 0.149 0 0
Nephron development R-HSA-9831926 7.098822e-01 0.149 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.104177e-01 0.148 0 0
Transcription of the HIV genome R-HSA-167172 7.124480e-01 0.147 0 0
Elastic fibre formation R-HSA-1566948 7.155181e-01 0.145 0 0
Transmission across Chemical Synapses R-HSA-112315 7.170656e-01 0.144 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.174922e-01 0.144 0 0
Parasite infection R-HSA-9664407 7.174922e-01 0.144 0 0
Leishmania phagocytosis R-HSA-9664417 7.174922e-01 0.144 0 0
Interferon gamma signaling R-HSA-877300 7.188814e-01 0.143 0 0
NGF-stimulated transcription R-HSA-9031628 7.221881e-01 0.141 0 0
Metal ion SLC transporters R-HSA-425410 7.221881e-01 0.141 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.261309e-01 0.139 0 0
Lipophagy R-HSA-9613354 7.266866e-01 0.139 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.266866e-01 0.139 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.266866e-01 0.139 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.266866e-01 0.139 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.266866e-01 0.139 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.266866e-01 0.139 0 0
Interleukin-1 processing R-HSA-448706 7.266866e-01 0.139 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.266866e-01 0.139 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.266866e-01 0.139 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.266866e-01 0.139 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.266866e-01 0.139 0 0
mRNA Capping R-HSA-72086 7.284837e-01 0.138 0 0
Glucagon-type ligand receptors R-HSA-420092 7.284837e-01 0.138 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.294014e-01 0.137 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.312092e-01 0.136 0 0
RAS processing R-HSA-9648002 7.312092e-01 0.136 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.315501e-01 0.136 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.315501e-01 0.136 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.315501e-01 0.136 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.315501e-01 0.136 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.315501e-01 0.136 0 0
Maturation of nucleoprotein R-HSA-9694631 7.315501e-01 0.136 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.427749e-01 0.129 0 0
Diseases of Immune System R-HSA-5260271 7.462417e-01 0.127 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.462417e-01 0.127 0 0
PI3K Cascade R-HSA-109704 7.496126e-01 0.125 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.518259e-01 0.124 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.518259e-01 0.124 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.518259e-01 0.124 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.518259e-01 0.124 0 0
Creatine metabolism R-HSA-71288 7.518259e-01 0.124 0 0
Mitochondrial biogenesis R-HSA-1592230 7.538793e-01 0.123 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.547003e-01 0.122 0 0
DNA replication initiation R-HSA-68952 7.547003e-01 0.122 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.547003e-01 0.122 0 0
Interleukin-27 signaling R-HSA-9020956 7.547003e-01 0.122 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.547003e-01 0.122 0 0
Parasitic Infection Pathways R-HSA-9824443 7.575342e-01 0.121 0 0
Leishmania infection R-HSA-9658195 7.575342e-01 0.121 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.589981e-01 0.120 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.619424e-01 0.118 0 0
Mitochondrial protein import R-HSA-1268020 7.660662e-01 0.116 0 0
Heme signaling R-HSA-9707616 7.660662e-01 0.116 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.707673e-01 0.113 0 0
Signalling to RAS R-HSA-167044 7.707673e-01 0.113 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.707699e-01 0.113 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.743629e-01 0.111 0 0
Neurexins and neuroligins R-HSA-6794361 7.749722e-01 0.111 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.749722e-01 0.111 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.798442e-01 0.108 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.798442e-01 0.108 0 0
vRNA Synthesis R-HSA-192814 7.798442e-01 0.108 0 0
vRNP Assembly R-HSA-192905 7.798442e-01 0.108 0 0
Propionyl-CoA catabolism R-HSA-71032 7.798442e-01 0.108 0 0
Synthesis of PI R-HSA-1483226 7.798442e-01 0.108 0 0
LGI-ADAM interactions R-HSA-5682910 7.798442e-01 0.108 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.798442e-01 0.108 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.798442e-01 0.108 0 0
Interleukin-2 signaling R-HSA-9020558 7.798442e-01 0.108 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.868916e-01 0.104 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.874734e-01 0.104 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.884347e-01 0.103 0 0
Nuclear RNA decay R-HSA-9930044 7.919752e-01 0.101 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.919752e-01 0.101 0 0
RSV-host interactions R-HSA-9833110 8.021493e-01 0.096 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.024120e-01 0.096 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.024120e-01 0.096 0 0
Plasmalogen biosynthesis R-HSA-75896 8.024120e-01 0.096 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.024120e-01 0.096 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.024120e-01 0.096 0 0
Sodium/Calcium exchangers R-HSA-425561 8.024120e-01 0.096 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.048903e-01 0.094 0 0
Free fatty acid receptors R-HSA-444209 8.048903e-01 0.094 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.057685e-01 0.094 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.057685e-01 0.094 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.187829e-01 0.087 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.187829e-01 0.087 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.193201e-01 0.087 0 0
Integrin cell surface interactions R-HSA-216083 8.193201e-01 0.087 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.197062e-01 0.086 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.201968e-01 0.086 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.201968e-01 0.086 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.201968e-01 0.086 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.201968e-01 0.086 0 0
Biosynthesis of maresins R-HSA-9018682 8.201968e-01 0.086 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.226677e-01 0.085 0 0
Repression of WNT target genes R-HSA-4641265 8.226677e-01 0.085 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.226677e-01 0.085 0 0
Acetylation R-HSA-156582 8.226677e-01 0.085 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.226677e-01 0.085 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.226677e-01 0.085 0 0
Interleukin-35 Signalling R-HSA-8984722 8.226677e-01 0.085 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.226677e-01 0.085 0 0
G alpha (q) signalling events R-HSA-416476 8.270633e-01 0.082 0 0
Regulated Necrosis R-HSA-5218859 8.280741e-01 0.082 0 0
IRS-mediated signalling R-HSA-112399 8.296966e-01 0.081 0 0
Regulation of insulin secretion R-HSA-422356 8.307797e-01 0.081 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.344169e-01 0.079 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.344169e-01 0.079 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.344169e-01 0.079 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.408479e-01 0.075 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.408479e-01 0.075 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.408479e-01 0.075 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.408479e-01 0.075 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.408479e-01 0.075 0 0
Interleukin-6 signaling R-HSA-1059683 8.408479e-01 0.075 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.408479e-01 0.075 0 0
Triglyceride catabolism R-HSA-163560 8.425916e-01 0.074 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.476122e-01 0.072 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.476122e-01 0.072 0 0
Laminin interactions R-HSA-3000157 8.476122e-01 0.072 0 0
Neuronal System R-HSA-112316 8.478361e-01 0.072 0 0
GABA receptor activation R-HSA-977443 8.569856e-01 0.067 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.571653e-01 0.067 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.571653e-01 0.067 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.571653e-01 0.067 0 0
Transport of fatty acids R-HSA-804914 8.571653e-01 0.067 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.571653e-01 0.067 0 0
Hydrolysis of LPC R-HSA-1483115 8.571653e-01 0.067 0 0
cGMP effects R-HSA-418457 8.571653e-01 0.067 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.571653e-01 0.067 0 0
Physiological factors R-HSA-5578768 8.571653e-01 0.067 0 0
Malate-aspartate shuttle R-HSA-9856872 8.571653e-01 0.067 0 0
HDL assembly R-HSA-8963896 8.571653e-01 0.067 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.571653e-01 0.067 0 0
P2Y receptors R-HSA-417957 8.571653e-01 0.067 0 0
Zinc transporters R-HSA-435354 8.571653e-01 0.067 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.571653e-01 0.067 0 0
Signaling by Insulin receptor R-HSA-74752 8.590123e-01 0.066 0 0
Metabolism of proteins R-HSA-392499 8.594309e-01 0.066 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.598435e-01 0.066 0 0
TRP channels R-HSA-3295583 8.598435e-01 0.066 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.615861e-01 0.065 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.636402e-01 0.064 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.636402e-01 0.064 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.652301e-01 0.063 0 0
Aquaporin-mediated transport R-HSA-445717 8.652301e-01 0.063 0 0
Ca2+ pathway R-HSA-4086398 8.690653e-01 0.061 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.690653e-01 0.061 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.711696e-01 0.060 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.711696e-01 0.060 0 0
Insulin processing R-HSA-264876 8.711696e-01 0.060 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.715497e-01 0.060 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.718105e-01 0.060 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.718105e-01 0.060 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.718105e-01 0.060 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.718105e-01 0.060 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.718105e-01 0.060 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.718105e-01 0.060 0 0
Biotin transport and metabolism R-HSA-196780 8.718105e-01 0.060 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.718105e-01 0.060 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.718105e-01 0.060 0 0
Other semaphorin interactions R-HSA-416700 8.718105e-01 0.060 0 0
DNA Damage Reversal R-HSA-73942 8.718105e-01 0.060 0 0
Signaling by PDGF R-HSA-186797 8.730708e-01 0.059 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.730708e-01 0.059 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.732054e-01 0.059 0 0
Telomere Extension By Telomerase R-HSA-171319 8.816476e-01 0.055 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.816476e-01 0.055 0 0
Interleukin-2 family signaling R-HSA-451927 8.821715e-01 0.054 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.830147e-01 0.054 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.849549e-01 0.053 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.849549e-01 0.053 0 0
Atorvastatin ADME R-HSA-9754706 8.849549e-01 0.053 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.849549e-01 0.053 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.849549e-01 0.053 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.849549e-01 0.053 0 0
Fructose catabolism R-HSA-70350 8.849549e-01 0.053 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.849549e-01 0.053 0 0
Attachment and Entry R-HSA-9678110 8.849549e-01 0.053 0 0
Mitochondrial Uncoupling R-HSA-166187 8.849549e-01 0.053 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.864250e-01 0.052 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.864250e-01 0.052 0 0
IGF1R signaling cascade R-HSA-2428924 8.875947e-01 0.052 0 0
Potassium Channels R-HSA-1296071 8.903231e-01 0.050 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.913322e-01 0.050 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.913322e-01 0.050 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.943054e-01 0.049 0 0
Innate Immune System R-HSA-168249 8.944319e-01 0.048 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.967522e-01 0.047 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.967522e-01 0.047 0 0
Galactose catabolism R-HSA-70370 8.967522e-01 0.047 0 0
Coenzyme A biosynthesis R-HSA-196783 8.967522e-01 0.047 0 0
Integration of energy metabolism R-HSA-163685 8.983829e-01 0.047 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.984242e-01 0.047 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.984242e-01 0.047 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.002760e-01 0.046 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.002760e-01 0.046 0 0
Neurotransmitter clearance R-HSA-112311 9.002760e-01 0.046 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.002760e-01 0.046 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.057685e-01 0.043 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.057685e-01 0.043 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.073403e-01 0.042 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.073403e-01 0.042 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.073403e-01 0.042 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.073403e-01 0.042 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.073403e-01 0.042 0 0
Choline catabolism R-HSA-6798163 9.073403e-01 0.042 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.073403e-01 0.042 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.073403e-01 0.042 0 0
Paracetamol ADME R-HSA-9753281 9.080601e-01 0.042 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.085289e-01 0.042 0 0
tRNA processing R-HSA-72306 9.117697e-01 0.040 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.165171e-01 0.038 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.168432e-01 0.038 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.168432e-01 0.038 0 0
PKA activation in glucagon signalling R-HSA-164378 9.168432e-01 0.038 0 0
PKA activation R-HSA-163615 9.168432e-01 0.038 0 0
Tie2 Signaling R-HSA-210993 9.168432e-01 0.038 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.168432e-01 0.038 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.168432e-01 0.038 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.179404e-01 0.037 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.231502e-01 0.035 0 0
Cardiogenesis R-HSA-9733709 9.231502e-01 0.035 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.253720e-01 0.034 0 0
Specification of the neural plate border R-HSA-9834899 9.253720e-01 0.034 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.253720e-01 0.034 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.253720e-01 0.034 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.253720e-01 0.034 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.271928e-01 0.033 0 0
ECM proteoglycans R-HSA-3000178 9.277103e-01 0.033 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.296062e-01 0.032 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.296062e-01 0.032 0 0
Triglyceride metabolism R-HSA-8979227 9.303033e-01 0.031 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.305681e-01 0.031 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.330266e-01 0.030 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.330266e-01 0.030 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.330266e-01 0.030 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.330266e-01 0.030 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.330266e-01 0.030 0 0
Pregnenolone biosynthesis R-HSA-196108 9.330266e-01 0.030 0 0
Post-translational protein modification R-HSA-597592 9.339769e-01 0.030 0 0
tRNA Aminoacylation R-HSA-379724 9.350450e-01 0.029 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.355469e-01 0.029 0 0
eNOS activation R-HSA-203615 9.355469e-01 0.029 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.355469e-01 0.029 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.355469e-01 0.029 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.398964e-01 0.027 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.398964e-01 0.027 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.398964e-01 0.027 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.398964e-01 0.027 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.398964e-01 0.027 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.398964e-01 0.027 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.410100e-01 0.026 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.410100e-01 0.026 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.410100e-01 0.026 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.422929e-01 0.026 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.460310e-01 0.024 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.460619e-01 0.024 0 0
Serine metabolism R-HSA-977347 9.460619e-01 0.024 0 0
Glutathione synthesis and recycling R-HSA-174403 9.460619e-01 0.024 0 0
Attachment and Entry R-HSA-9694614 9.460619e-01 0.024 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.475644e-01 0.023 0 0
Voltage gated Potassium channels R-HSA-1296072 9.506430e-01 0.022 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.506430e-01 0.022 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.515952e-01 0.022 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.515952e-01 0.022 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.515952e-01 0.022 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.515952e-01 0.022 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.515952e-01 0.022 0 0
Cellular hexose transport R-HSA-189200 9.515952e-01 0.022 0 0
Fructose metabolism R-HSA-5652084 9.515952e-01 0.022 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.515952e-01 0.022 0 0
The phototransduction cascade R-HSA-2514856 9.531023e-01 0.021 0 0
Adipogenesis R-HSA-9843745 9.548699e-01 0.020 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.548771e-01 0.020 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.565612e-01 0.019 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.565612e-01 0.019 0 0
Formation of the ureteric bud R-HSA-9830674 9.565612e-01 0.019 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.566977e-01 0.019 0 0
Pentose phosphate pathway R-HSA-71336 9.587623e-01 0.018 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.600335e-01 0.018 0 0
Kidney development R-HSA-9830369 9.608228e-01 0.017 0 0
CYP2E1 reactions R-HSA-211999 9.610180e-01 0.017 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.610180e-01 0.017 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.610180e-01 0.017 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.610180e-01 0.017 0 0
Complex III assembly R-HSA-9865881 9.610180e-01 0.017 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.610180e-01 0.017 0 0
Interleukin-6 family signaling R-HSA-6783589 9.610180e-01 0.017 0 0
Formation of the cornified envelope R-HSA-6809371 9.613964e-01 0.017 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.623255e-01 0.017 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.623255e-01 0.017 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.629751e-01 0.016 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.650178e-01 0.015 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.650178e-01 0.015 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.650178e-01 0.015 0 0
Hyaluronan degradation R-HSA-2160916 9.650178e-01 0.015 0 0
Formation of the nephric duct R-HSA-9830364 9.650178e-01 0.015 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.650178e-01 0.015 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.650178e-01 0.015 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.677682e-01 0.014 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.685850e-01 0.014 0 0
HIV Transcription Initiation R-HSA-167161 9.685850e-01 0.014 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.685850e-01 0.014 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.686073e-01 0.014 0 0
Urea cycle R-HSA-70635 9.686073e-01 0.014 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.686073e-01 0.014 0 0
Dectin-2 family R-HSA-5621480 9.711078e-01 0.013 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.718288e-01 0.012 0 0
Signaling by BMP R-HSA-201451 9.718288e-01 0.012 0 0
Triglyceride biosynthesis R-HSA-75109 9.718288e-01 0.012 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.718288e-01 0.012 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.730262e-01 0.012 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.733830e-01 0.012 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.738361e-01 0.012 0 0
Insulin receptor recycling R-HSA-77387 9.747198e-01 0.011 0 0
Prednisone ADME R-HSA-9757110 9.747198e-01 0.011 0 0
Pyroptosis R-HSA-5620971 9.747198e-01 0.011 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.753302e-01 0.011 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.754875e-01 0.011 0 0
Surfactant metabolism R-HSA-5683826 9.761329e-01 0.010 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.761329e-01 0.010 0 0
Thyroxine biosynthesis R-HSA-209968 9.773143e-01 0.010 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.773143e-01 0.010 0 0
DARPP-32 events R-HSA-180024 9.773143e-01 0.010 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.782341e-01 0.010 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.796426e-01 0.009 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.809447e-01 0.008 0 0
Cargo concentration in the ER R-HSA-5694530 9.817322e-01 0.008 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.817322e-01 0.008 0 0
PI Metabolism R-HSA-1483255 9.824623e-01 0.008 0 0
Interleukin-10 signaling R-HSA-6783783 9.829650e-01 0.007 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.842392e-01 0.007 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.852901e-01 0.006 0 0
Azathioprine ADME R-HSA-9748787 9.863223e-01 0.006 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.868002e-01 0.006 0 0
Heme degradation R-HSA-189483 9.868002e-01 0.006 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.874616e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.881554e-01 0.005 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.893715e-01 0.005 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.893715e-01 0.005 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.898782e-01 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 9.902952e-01 0.004 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.904628e-01 0.004 0 0
Glycosphingolipid transport R-HSA-9845576 9.904628e-01 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.904628e-01 0.004 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.912906e-01 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.914421e-01 0.004 0 0
NCAM1 interactions R-HSA-419037 9.914421e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.914421e-01 0.004 0 0
G alpha (s) signalling events R-HSA-418555 9.921689e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.923209e-01 0.003 0 0
Aspirin ADME R-HSA-9749641 9.925060e-01 0.003 0 0
Synthesis of PA R-HSA-1483166 9.929295e-01 0.003 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.930569e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.930569e-01 0.003 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.935707e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.938172e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.938172e-01 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.939392e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.941548e-01 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.944522e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.944522e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.946867e-01 0.002 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.947090e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.951528e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.956295e-01 0.002 0 0
Mitochondrial protein degradation R-HSA-9837999 9.959750e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.959750e-01 0.002 0 0
Xenobiotics R-HSA-211981 9.963787e-01 0.002 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.963787e-01 0.002 0 0
Methylation R-HSA-156581 9.964040e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.964040e-01 0.002 0 0
GPCR downstream signalling R-HSA-388396 9.965210e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.965222e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.967734e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.968603e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.970133e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.974024e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.974024e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.975381e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.975557e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.977031e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.978487e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.979088e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.981237e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.981596e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.981667e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.981667e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.983166e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.984389e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.985286e-01 0.001 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.986259e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.986259e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.986448e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.987841e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.990213e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.990709e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.991182e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.992932e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.993081e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.993659e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.994311e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.994415e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.995082e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.995228e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.995421e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.995935e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.996174e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997034e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997034e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997034e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.997858e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998079e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998079e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998079e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998276e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998756e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998959e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999194e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999194e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999352e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999432e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999463e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999485e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999532e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.999781e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999810e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999821e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999856e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999878e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999879e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999881e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999886e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999891e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999908e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.999909e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.999924e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999966e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999980e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999982e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999984e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999989e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999995e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999997e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999997e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways