PLK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O15350 S48 EPSD|PSP TP73 P73 yFDLPQSSRGNNEVVGGTDssMDVFHLEGMTTSVMAQFNLL
O43719 S702 Sugiyama HTATSF1 EDADGKEVEDADEKLFEDDDsNEKLFDEEEDssEKLFDDsD
O43852 S44 EPSD|PSP|Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852 T196 EPSD|PSP|Sugiyama CALU FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O43852 T60 EPSD|PSP CALU NDAQsFDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKI
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S66 Sugiyama EIF5B IF2 KIAA0741 KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O95218 S165 Sugiyama ZRANB2 ZIS ZNF265 LKEVEDKEsEGEEEDEDEDLsKyKLDEDEDEDDADLsKyNL
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P02511 S19 PSP CRYAB CRYA2 HSPB5 __MDIAIHHPWIRRPFFPFHsPsRLFDQFFGEHLLESDLFP
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06748 S4 GPS6|SIGNOR|EPSD|PSP NPM1 NPM _________________MEDsMDMDMsPLRPQNyLFGCELK
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P23434 S160 Sugiyama GCSH EDGWLIKMtLsNPsELDELMsEEAyEKYIKSIEE_______
P25705 S53 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P31943 S63 Sugiyama HNRNPH1 HNRPH HNRPH1 IRFIYTREGRPsGEAFVELEsEDEVKLALKKDRETMGHRyV
P37840 S129 SIGNOR|EPSD|PSP SNCA NACP PARK1 QEGILEDMPVDPDNEAyEMPsEEGyQDyEPEA_________
P40855 S147 Sugiyama PEX19 HK33 PXF OK/SW-cl.22 SCLKETLSGLAKNATDLQNssMsEEELTKAMEGLGMDEGDG
P52597 S63 Sugiyama HNRNPF HNRPF VHFIYTREGRQsGEAFVELGsEDDVKMALKKDRESMGHRyI
P53350 S137 EPSD|PSP PLK1 PLK HGFFEDNDFVFVVLELCRRRsLLELHKRRKALTEPEARYYL
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P62258 T208 EPSD|PSP|Sugiyama YWHAE PDRACRLAKAAFDDAIAELDtLsEEsyKDstLIMQLLRDNL
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P67936 T241 Sugiyama TPM4 EEKLAQAKEENVGLHQtLDQtLNELNCI_____________
P68363 S439 Sugiyama TUBA1B SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q01105 S133 Sugiyama SET DEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLS
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q13435 S289 Sugiyama SF3B2 SAP145 IPQALEKILQLKESRQEEMNsQQEEEEMETDARssLGQsAs
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14978 S637 Sugiyama NOLC1 KIAA0035 NS5ATP13 GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER
Q14978 S643 Sugiyama NOLC1 KIAA0035 NS5ATP13 sPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGERANQVLK
Q14C86 S740 Sugiyama GAPVD1 GAPEX5 KIAA1521 RAP6 LPSDSEAPDLKQEERLQELEsCsGLGstSDDTDVREVSSRP
Q15056 T100 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 KFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRK
Q15084 S169 Sugiyama PDIA6 ERP5 P5 TXNDC7 GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15293 S80 Sugiyama RCN1 RCN HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15293 T211 Sugiyama RCN1 RCN FTAFLHPEEFEHMKEIVVLEtLEDIDKNGDGFVDQDEyIAD
Q16143 S118 SIGNOR|EPSD|PSP SNCB VAQEAAEEPLIEPLMEPEGEsYEDPPQEEyQEYEPEA____
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q71U36 S439 Sugiyama TUBA1A TUBA3 SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q969H0 S176 SIGNOR|EPSD|PSP FBXW7 FBW7 FBX30 SEL10 QLSSPFYTKTTKMKRKLDHGsEVRSFSLGKKPCKVSEYTST
Q969H0 S25 EPSD|PSP FBXW7 FBW7 FBX30 SEL10 LLSVGsKRRRTGGsLRGNPSssQVDEEQMNRVVEEEQQQQL
Q969H0 S349 EPSD|PSP FBXW7 FBW7 FBX30 SEL10 GIDEPLHIKRRKVIKPGFIHsPWKSAYIRQHRIDTNWRRGE
Q96A49 S313 Sugiyama SYAP1 PRO3113 EMEQLVLDKKQEEtAVLEEDsADWEKELQQELQEyEVVtES
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9H1E3 S132 Sugiyama NUCKS1 NUCKS JC7 GsEEEQEEEDEAPFQEKDsGsDEDFLMEDDDDsDyGSsKKK
Q9HC77 S589 GPS6|SIGNOR|EPSD|PSP CPAP CENPJ LAP LIP1 EKENLELDEFLFLEQAADEIsFSSNSsFVLKILERDQQICK
Q9HC77 S595 GPS6|SIGNOR|EPSD|PSP CPAP CENPJ LAP LIP1 LDEFLFLEQAADEIsFSSNSsFVLKILERDQQICKGHRMSS
Q9NYY3 S248 Sugiyama PLK2 SNK ARLEPLEHRRRtICGtPNyLsPEVLNKQGHGCESDIWALGC
Q9NYY3 T103 Sugiyama PLK2 SNK CRGKVLGKGGFAKCYEMTDLtNNKVYAAKIIPHSRVAKPHQ
Q9NYY3 T239 Sugiyama PLK2 SNK LKVGDFGLAARLEPLEHRRRtICGtPNyLsPEVLNKQGHGC
Q9NYY3 T243 Sugiyama PLK2 SNK DFGLAARLEPLEHRRRtICGtPNyLsPEVLNKQGHGCESDI
Q9NYY3 T424 Sugiyama PLK2 SNK KTSITQQPSKHRTDEELQPPtTTVARSGtPAVENKQQIGDA
Q9NYY3 T432 Sugiyama PLK2 SNK SKHRTDEELQPPtTTVARSGtPAVENKQQIGDAIRMIVRGT
Q9NYY3 Y246 Sugiyama PLK2 SNK LAARLEPLEHRRRtICGtPNyLsPEVLNKQGHGCESDIWAL
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.220446e-16 15.654 0 0
Cell Cycle, Mitotic R-HSA-69278 1.587619e-14 13.799 0 0
M Phase R-HSA-68886 3.175238e-13 12.498 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.981971e-11 10.098 0 0
Metabolism of RNA R-HSA-8953854 1.330227e-10 9.876 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.279234e-09 8.893 0 0
Mitotic Prometaphase R-HSA-68877 2.194980e-09 8.659 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.770573e-09 8.557 0 0
Cell-Cell communication R-HSA-1500931 1.768596e-08 7.752 0 0
Cellular Senescence R-HSA-2559583 3.466925e-08 7.460 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.930873e-08 7.406 0 0
Chromatin organization R-HSA-4839726 3.687223e-08 7.433 0 0
G2/M Transition R-HSA-69275 4.203761e-08 7.376 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.342488e-08 7.198 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.396351e-08 7.131 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.939725e-08 7.159 0 0
Cell Cycle Checkpoints R-HSA-69620 6.369309e-08 7.196 0 0
Signaling by ALK in cancer R-HSA-9700206 6.939725e-08 7.159 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.845346e-08 7.233 0 0
Aggrephagy R-HSA-9646399 8.528254e-08 7.069 0 0
Deubiquitination R-HSA-5688426 8.573118e-08 7.067 0 0
Cell junction organization R-HSA-446728 1.152560e-07 6.938 0 0
Mitotic Anaphase R-HSA-68882 1.111770e-07 6.954 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.288769e-07 6.890 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.554463e-07 6.808 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.519612e-07 6.818 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.508392e-07 6.821 0 0
G2/M Checkpoints R-HSA-69481 1.902389e-07 6.721 0 0
Chromatin modifying enzymes R-HSA-3247509 3.363918e-07 6.473 0 0
DNA Double Strand Break Response R-HSA-5693606 4.104394e-07 6.387 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.861693e-07 6.313 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.013015e-07 6.221 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.013015e-07 6.221 0 0
Separation of Sister Chromatids R-HSA-2467813 5.923486e-07 6.227 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.072460e-07 6.217 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.994368e-07 6.155 0 0
mRNA Splicing R-HSA-72172 7.742449e-07 6.111 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.904593e-07 6.050 0 0
Protein ubiquitination R-HSA-8852135 1.090575e-06 5.962 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.200920e-06 5.920 0 0
Adherens junctions interactions R-HSA-418990 1.283309e-06 5.892 0 0
Recycling pathway of L1 R-HSA-437239 1.323070e-06 5.878 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.718110e-06 5.765 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.039170e-06 5.691 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.289893e-06 5.640 0 0
DNA Repair R-HSA-73894 2.740715e-06 5.562 0 0
Cell-cell junction organization R-HSA-421270 2.956475e-06 5.529 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.929103e-06 5.533 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.174853e-06 5.498 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.298124e-06 5.482 0 0
Selective autophagy R-HSA-9663891 3.545962e-06 5.450 0 0
PKR-mediated signaling R-HSA-9833482 3.497809e-06 5.456 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.607409e-06 5.443 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.834293e-06 5.416 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.361944e-06 5.360 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.596095e-06 5.181 0 0
Mitotic Prophase R-HSA-68875 7.711876e-06 5.113 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.060190e-06 5.043 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.224312e-06 5.035 0 0
Apoptotic execution phase R-HSA-75153 1.023308e-05 4.990 0 0
Ub-specific processing proteases R-HSA-5689880 1.146244e-05 4.941 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.457726e-05 4.836 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.680250e-05 4.775 0 0
Post NMDA receptor activation events R-HSA-438064 1.843569e-05 4.734 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.939938e-05 4.712 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.142199e-05 4.669 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.162043e-05 4.665 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.282110e-05 4.642 0 0
Nucleosome assembly R-HSA-774815 2.394283e-05 4.621 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.394283e-05 4.621 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.870795e-05 4.542 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.947412e-05 4.531 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.947412e-05 4.531 0 0
Axon guidance R-HSA-422475 3.141666e-05 4.503 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.313928e-05 4.480 0 0
HDACs deacetylate histones R-HSA-3214815 3.515134e-05 4.454 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.056601e-05 4.392 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.056601e-05 4.392 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.408272e-05 4.356 0 0
ESR-mediated signaling R-HSA-8939211 4.484230e-05 4.348 0 0
Nervous system development R-HSA-9675108 5.036065e-05 4.298 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.126743e-05 4.290 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.446465e-05 4.264 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.827039e-05 4.235 0 0
Homology Directed Repair R-HSA-5693538 5.970004e-05 4.224 0 0
Meiotic synapsis R-HSA-1221632 6.111091e-05 4.214 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.524273e-05 4.124 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.635522e-05 4.117 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.014981e-05 4.096 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.967208e-05 4.047 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.967208e-05 4.047 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.074331e-05 4.042 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.001923e-04 3.999 0 0
Josephin domain DUBs R-HSA-5689877 1.013610e-04 3.994 0 0
Kinesins R-HSA-983189 1.074700e-04 3.969 0 0
Regulation of TP53 Activity R-HSA-5633007 1.098155e-04 3.959 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.186308e-04 3.926 0 0
Macroautophagy R-HSA-1632852 1.271935e-04 3.896 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.333231e-04 3.875 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.333714e-04 3.875 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.496668e-04 3.825 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.512114e-04 3.820 0 0
Regulation of signaling by CBL R-HSA-912631 1.646529e-04 3.783 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.621778e-04 3.790 0 0
Cellular responses to stress R-HSA-2262752 1.728675e-04 3.762 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.750040e-04 3.757 0 0
Gap junction trafficking and regulation R-HSA-157858 1.833882e-04 3.737 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.104283e-04 3.677 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.206559e-04 3.656 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.286043e-04 3.641 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.342826e-04 3.630 0 0
Autophagy R-HSA-9612973 2.460566e-04 3.609 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.589615e-04 3.587 0 0
Apoptosis R-HSA-109581 2.634458e-04 3.579 0 0
Signaling by EGFR R-HSA-177929 3.099416e-04 3.509 0 0
Centrosome maturation R-HSA-380287 3.144302e-04 3.502 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.224028e-04 3.492 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.237117e-04 3.490 0 0
PTEN Regulation R-HSA-6807070 3.736027e-04 3.428 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.742225e-04 3.427 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.733185e-04 3.428 0 0
Regulation of CDH1 Function R-HSA-9764561 3.780812e-04 3.422 0 0
L1CAM interactions R-HSA-373760 3.974393e-04 3.401 0 0
Gap junction trafficking R-HSA-190828 4.379187e-04 3.359 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.444144e-04 3.352 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.444144e-04 3.352 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.589452e-04 3.338 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.749812e-04 3.323 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.749812e-04 3.323 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.248366e-04 3.280 0 0
RNA Polymerase I Transcription R-HSA-73864 5.208111e-04 3.283 0 0
Signal Transduction R-HSA-162582 5.321227e-04 3.274 0 0
Regulation of PTEN localization R-HSA-8948747 5.495050e-04 3.260 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.495050e-04 3.260 0 0
Cilium Assembly R-HSA-5617833 5.512446e-04 3.259 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.735774e-04 3.241 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.930467e-04 3.227 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.098820e-04 3.215 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.098820e-04 3.215 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.342780e-04 3.198 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.696173e-04 3.174 0 0
Myogenesis R-HSA-525793 6.342780e-04 3.198 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.002287e-04 3.155 0 0
Meiosis R-HSA-1500620 7.144844e-04 3.146 0 0
Gap junction assembly R-HSA-190861 7.334486e-04 3.135 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.199307e-04 3.086 0 0
Cellular responses to stimuli R-HSA-8953897 8.271821e-04 3.082 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.364165e-04 3.078 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.364165e-04 3.078 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.624058e-04 3.064 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.414899e-04 3.075 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.216997e-04 3.035 0 0
HATs acetylate histones R-HSA-3214847 9.002998e-04 3.046 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.515575e-04 3.022 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 9.525438e-04 3.021 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 9.525438e-04 3.021 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.625055e-04 3.017 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.047819e-03 2.980 0 0
Nucleotide Excision Repair R-HSA-5696398 1.134006e-03 2.945 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.134006e-03 2.945 0 0
Signaling by Hippo R-HSA-2028269 1.140426e-03 2.943 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.145923e-03 2.941 0 0
S Phase R-HSA-69242 1.156891e-03 2.937 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.214212e-03 2.916 0 0
EPH-Ephrin signaling R-HSA-2682334 1.250147e-03 2.903 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.308787e-03 2.883 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.499392e-03 2.824 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.404821e-03 2.852 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.512622e-03 2.820 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.499392e-03 2.824 0 0
Gene Silencing by RNA R-HSA-211000 1.459460e-03 2.836 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.523940e-03 2.817 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.556719e-03 2.808 0 0
Signaling by ERBB2 R-HSA-1227986 1.556719e-03 2.808 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.576449e-03 2.802 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.576449e-03 2.802 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.576449e-03 2.802 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.576449e-03 2.802 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.615404e-03 2.792 1 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.751575e-03 2.757 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.812811e-03 2.742 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.940456e-03 2.712 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.048835e-03 2.688 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.048835e-03 2.688 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.098225e-03 2.678 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.098225e-03 2.678 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.132163e-03 2.671 0 0
Interferon Signaling R-HSA-913531 2.141844e-03 2.669 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.440499e-03 2.613 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.440499e-03 2.613 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.440499e-03 2.613 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.440499e-03 2.613 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.440499e-03 2.613 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.440499e-03 2.613 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.440499e-03 2.613 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.440499e-03 2.613 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.440499e-03 2.613 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.440499e-03 2.613 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.440499e-03 2.613 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.214644e-03 2.655 0 0
Programmed Cell Death R-HSA-5357801 2.384579e-03 2.623 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.492020e-03 2.603 0 0
Packaging Of Telomere Ends R-HSA-171306 2.492020e-03 2.603 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.492020e-03 2.603 0 0
Oncogene Induced Senescence R-HSA-2559585 2.513105e-03 2.600 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.548338e-03 2.594 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.694482e-03 2.570 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.701595e-03 2.568 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.795352e-03 2.554 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.852135e-03 2.545 0 0
Negative regulation of MET activity R-HSA-6807004 2.852135e-03 2.545 0 0
Gene expression (Transcription) R-HSA-74160 2.881862e-03 2.540 1 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.077196e-03 2.512 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.088559e-03 2.510 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.273702e-03 2.485 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.430707e-03 2.465 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.281472e-03 2.484 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.077109e-03 2.512 0 0
DNA Replication R-HSA-69306 3.335084e-03 2.477 0 0
Signaling by MET R-HSA-6806834 3.184281e-03 2.497 0 0
FLT3 Signaling R-HSA-9607240 3.273702e-03 2.485 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.395350e-03 2.469 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.471226e-03 2.460 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.509802e-03 2.455 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.632988e-03 2.440 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.632988e-03 2.440 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.738352e-03 2.427 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.743809e-03 2.427 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.922216e-03 2.406 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.922216e-03 2.406 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.925410e-03 2.406 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.967159e-03 2.402 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.044805e-03 2.393 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.044805e-03 2.393 0 0
HCMV Early Events R-HSA-9609690 4.448247e-03 2.352 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.566838e-03 2.340 0 0
Chromosome Maintenance R-HSA-73886 4.770832e-03 2.321 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.805272e-03 2.318 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.843000e-03 2.315 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.843000e-03 2.315 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.244112e-03 2.280 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.244112e-03 2.280 0 0
NF-kB is activated and signals survival R-HSA-209560 5.244112e-03 2.280 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.244112e-03 2.280 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.379047e-03 2.269 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.379047e-03 2.269 0 0
p75NTR signals via NF-kB R-HSA-193639 5.379047e-03 2.269 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.419868e-03 2.266 0 0
Dual incision in TC-NER R-HSA-6782135 5.540199e-03 2.256 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.543917e-03 2.256 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.627807e-03 2.250 0 0
Death Receptor Signaling R-HSA-73887 6.138298e-03 2.212 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.211108e-03 2.142 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.768773e-03 2.169 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.638722e-03 2.178 0 0
TCR signaling R-HSA-202403 7.074942e-03 2.150 0 0
Membrane Trafficking R-HSA-199991 7.119739e-03 2.148 0 0
Negative regulation of FLT3 R-HSA-9706369 7.211108e-03 2.142 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 7.339568e-03 2.134 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.339568e-03 2.134 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.372769e-03 2.132 0 0
FLT3 signaling in disease R-HSA-9682385 7.660412e-03 2.116 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.661664e-03 2.062 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 8.661664e-03 2.062 0 0
TNF signaling R-HSA-75893 8.763362e-03 2.057 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.920483e-03 2.050 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.920483e-03 2.050 0 0
Meiotic recombination R-HSA-912446 8.987410e-03 2.046 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.142925e-03 2.039 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 9.144158e-03 2.039 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.451621e-03 2.024 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.478032e-03 2.023 0 0
Co-inhibition by PD-1 R-HSA-389948 9.499662e-03 2.022 0 0
Diseases of programmed cell death R-HSA-9645723 9.615281e-03 2.017 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.703158e-03 2.013 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.917803e-03 2.004 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 9.917803e-03 2.004 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 9.917803e-03 2.004 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 9.917803e-03 2.004 0 0
DNA methylation R-HSA-5334118 1.035247e-02 1.985 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.035247e-02 1.985 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.071011e-02 1.970 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.064827e-02 1.973 0 0
mRNA 3'-end processing R-HSA-72187 1.039593e-02 1.983 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.039593e-02 1.983 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.197340e-02 1.922 0 0
TGFBR3 expression R-HSA-9839394 1.195572e-02 1.922 0 0
Long-term potentiation R-HSA-9620244 1.195572e-02 1.922 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.110424e-02 1.955 0 0
Intraflagellar transport R-HSA-5620924 1.234181e-02 1.909 0 0
HDMs demethylate histones R-HSA-3214842 1.195572e-02 1.922 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.035247e-02 1.985 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.234181e-02 1.909 0 0
Signaling by PTK6 R-HSA-8848021 1.107739e-02 1.956 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.107739e-02 1.956 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.276492e-02 1.894 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.276492e-02 1.894 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.276492e-02 1.894 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.277946e-02 1.893 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.277946e-02 1.893 0 0
Hedgehog 'off' state R-HSA-5610787 1.289454e-02 1.890 0 0
snRNP Assembly R-HSA-191859 1.317533e-02 1.880 0 0
Metabolism of non-coding RNA R-HSA-194441 1.317533e-02 1.880 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.329659e-02 1.876 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.329659e-02 1.876 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.370791e-02 1.863 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.370791e-02 1.863 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.370791e-02 1.863 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.382016e-02 1.859 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.389718e-02 1.857 0 0
Cellular response to heat stress R-HSA-3371556 1.413967e-02 1.850 0 0
Degradation of CDH1 R-HSA-9766229 1.423842e-02 1.847 0 0
Metalloprotease DUBs R-HSA-5689901 1.458183e-02 1.836 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.466369e-02 1.834 0 0
Signalling to ERKs R-HSA-187687 1.510843e-02 1.821 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.521564e-02 1.818 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.662245e-02 1.779 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.896080e-02 1.722 0 0
Ephrin signaling R-HSA-3928664 1.554348e-02 1.808 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.776416e-02 1.750 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.776416e-02 1.750 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.909324e-02 1.719 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.554348e-02 1.808 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.743754e-02 1.759 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.554348e-02 1.808 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.726563e-02 1.763 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.595618e-02 1.797 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.909324e-02 1.719 0 0
MAP kinase activation R-HSA-450294 1.697365e-02 1.770 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.698385e-02 1.770 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.680196e-02 1.775 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.849046e-02 1.733 0 0
Signaling by NOTCH R-HSA-157118 1.873701e-02 1.727 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.849046e-02 1.733 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.849046e-02 1.733 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.731086e-02 1.762 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.743754e-02 1.759 0 0
Signaling by NTRKs R-HSA-166520 1.601554e-02 1.795 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.785055e-02 1.748 0 0
Signaling by TGFB family members R-HSA-9006936 1.604384e-02 1.795 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.761576e-02 1.754 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.945273e-02 1.711 0 0
HIV Life Cycle R-HSA-162587 2.005175e-02 1.698 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.020006e-02 1.695 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.030936e-02 1.692 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.061612e-02 1.686 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.068260e-02 1.684 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.068964e-02 1.684 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.068964e-02 1.684 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.075544e-02 1.683 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.075544e-02 1.683 0 0
Cleavage of the damaged purine R-HSA-110331 2.075544e-02 1.683 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.108779e-02 1.676 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.108779e-02 1.676 0 0
Signaling by ERBB4 R-HSA-1236394 2.129833e-02 1.672 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.187086e-02 1.660 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.226495e-02 1.652 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.232406e-02 1.651 0 0
MTOR signalling R-HSA-165159 2.327790e-02 1.633 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.327790e-02 1.633 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.398301e-02 1.620 0 0
Depurination R-HSA-73927 2.410510e-02 1.618 0 0
Amyloid fiber formation R-HSA-977225 2.452153e-02 1.610 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.460056e-02 1.609 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.460056e-02 1.609 0 0
Neurodegenerative Diseases R-HSA-8863678 2.487980e-02 1.604 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.487980e-02 1.604 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.504031e-02 1.601 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.504031e-02 1.601 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.533036e-02 1.596 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.551810e-02 1.593 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.551810e-02 1.593 0 0
Maturation of protein E R-HSA-9694493 2.551810e-02 1.593 0 0
Maturation of protein E R-HSA-9683683 2.551810e-02 1.593 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.626368e-02 1.581 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.626368e-02 1.581 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.626368e-02 1.581 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.626368e-02 1.581 0 0
Unwinding of DNA R-HSA-176974 2.626368e-02 1.581 0 0
Signaling by SCF-KIT R-HSA-1433557 2.669026e-02 1.574 0 0
Synthesis of DNA R-HSA-69239 2.689042e-02 1.570 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.729968e-02 1.564 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.140233e-02 1.503 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.140233e-02 1.503 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.242410e-02 1.489 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.242410e-02 1.489 0 0
CREB phosphorylation R-HSA-199920 3.680459e-02 1.434 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.776086e-02 1.557 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.949412e-02 1.530 0 0
EGFR downregulation R-HSA-182971 3.448125e-02 1.462 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.448125e-02 1.462 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.448125e-02 1.462 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.334482e-02 1.477 0 0
DNA Damage Bypass R-HSA-73893 2.888196e-02 1.539 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.652083e-02 1.437 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.196720e-02 1.495 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.776086e-02 1.557 0 0
Stabilization of p53 R-HSA-69541 2.783529e-02 1.555 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.888196e-02 1.539 0 0
PI3K/AKT activation R-HSA-198203 3.515042e-02 1.454 0 0
Signaling by VEGF R-HSA-194138 3.433218e-02 1.464 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.924630e-02 1.534 0 0
Heme signaling R-HSA-9707616 3.594432e-02 1.444 0 0
Nuclear import of Rev protein R-HSA-180746 2.880668e-02 1.541 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.774531e-02 1.557 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.907645e-02 1.536 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.196720e-02 1.495 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.194630e-02 1.496 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.175625e-02 1.498 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.652083e-02 1.437 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.348720e-02 1.475 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.196720e-02 1.495 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.225583e-02 1.491 0 0
Pexophagy R-HSA-9664873 3.515042e-02 1.454 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.810664e-02 1.419 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.833701e-02 1.416 0 0
RET signaling R-HSA-8853659 3.836635e-02 1.416 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.911596e-02 1.408 0 0
Signaling by TGFBR3 R-HSA-9839373 3.911596e-02 1.408 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.942039e-02 1.404 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.942039e-02 1.404 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.982842e-02 1.400 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.990547e-02 1.399 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.990547e-02 1.399 0 0
Regulation of KIT signaling R-HSA-1433559 3.990547e-02 1.399 0 0
Semaphorin interactions R-HSA-373755 3.993001e-02 1.399 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.002795e-02 1.398 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.151480e-02 1.382 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.208248e-02 1.376 0 0
mTORC1-mediated signalling R-HSA-166208 4.208248e-02 1.376 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.208248e-02 1.376 0 0
Signaling by KIT in disease R-HSA-9669938 4.208248e-02 1.376 0 0
RNA Polymerase II Transcription R-HSA-73857 4.241437e-02 1.372 1 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.344768e-02 1.362 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.389204e-02 1.358 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.389204e-02 1.358 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.404308e-02 1.356 0 0
Interleukin-17 signaling R-HSA-448424 4.524885e-02 1.344 0 0
PECAM1 interactions R-HSA-210990 4.569107e-02 1.340 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.569107e-02 1.340 0 0
Signaling by NOTCH1 R-HSA-1980143 4.601826e-02 1.337 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.605197e-02 1.337 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.605197e-02 1.337 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.605197e-02 1.337 0 0
Host Interactions of HIV factors R-HSA-162909 4.615117e-02 1.336 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.615761e-02 1.336 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.651156e-02 1.332 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.696608e-02 1.328 0 0
Depyrimidination R-HSA-73928 4.696608e-02 1.328 0 0
Protein folding R-HSA-391251 4.714564e-02 1.327 0 0
rRNA processing R-HSA-72312 4.875381e-02 1.312 0 0
Erythropoietin activates RAS R-HSA-9027284 4.940533e-02 1.306 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.940533e-02 1.306 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.940533e-02 1.306 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.940533e-02 1.306 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.940533e-02 1.306 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.994043e-02 1.302 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.994043e-02 1.302 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.995450e-02 1.301 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.995450e-02 1.301 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.032549e-02 1.298 0 0
Translesion Synthesis by POLH R-HSA-110320 5.032549e-02 1.298 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.054044e-02 1.296 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.054044e-02 1.296 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.054044e-02 1.296 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.054044e-02 1.296 0 0
SOS-mediated signalling R-HSA-112412 5.054044e-02 1.296 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.076519e-02 1.294 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.076519e-02 1.294 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.076519e-02 1.294 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.076519e-02 1.294 0 0
NADE modulates death signalling R-HSA-205025 5.076519e-02 1.294 0 0
HIV Infection R-HSA-162906 5.238350e-02 1.281 0 0
Reproduction R-HSA-1474165 5.238813e-02 1.281 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.288986e-02 1.277 0 0
Signaling by FGFR4 R-HSA-5654743 5.288986e-02 1.277 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.289045e-02 1.277 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.359036e-02 1.271 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.409640e-02 1.267 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.453594e-02 1.263 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.453594e-02 1.263 0 0
Pervasive developmental disorders R-HSA-9005895 7.184607e-02 1.144 0 0
Disorders of Nervous System Development R-HSA-9697154 7.184607e-02 1.144 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.184607e-02 1.144 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 7.184607e-02 1.144 0 0
Regulation of BACH1 activity R-HSA-9708530 6.018264e-02 1.221 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.018264e-02 1.221 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.984211e-02 1.223 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.984211e-02 1.223 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.984211e-02 1.223 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.984211e-02 1.223 0 0
Signalling to RAS R-HSA-167044 7.039145e-02 1.152 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.197811e-02 1.086 0 0
Signaling by Erythropoietin R-HSA-9006335 5.569022e-02 1.254 0 0
Late endosomal microautophagy R-HSA-9615710 5.569022e-02 1.254 0 0
DAP12 signaling R-HSA-2424491 6.393503e-02 1.194 0 0
Activation of the pre-replicative complex R-HSA-68962 6.393503e-02 1.194 0 0
Dual Incision in GG-NER R-HSA-5696400 6.024325e-02 1.220 0 0
Generation of second messenger molecules R-HSA-202433 6.366681e-02 1.196 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.688364e-02 1.245 0 0
Signaling by RAS mutants R-HSA-6802949 7.361750e-02 1.133 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.361750e-02 1.133 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.361750e-02 1.133 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.361750e-02 1.133 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.290054e-02 1.201 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.290054e-02 1.201 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.154139e-02 1.089 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.517137e-02 1.124 0 0
UCH proteinases R-HSA-5689603 7.691382e-02 1.114 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.052297e-02 1.152 0 0
Downstream signal transduction R-HSA-186763 7.291381e-02 1.137 0 0
Telomere Maintenance R-HSA-157579 7.480401e-02 1.126 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.697154e-02 1.114 0 0
DNA strand elongation R-HSA-69190 8.263330e-02 1.083 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.620563e-02 1.179 0 0
Nephrin family interactions R-HSA-373753 5.984211e-02 1.223 0 0
Mitophagy R-HSA-5205647 6.024325e-02 1.220 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.077018e-02 1.093 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.138642e-02 1.212 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.366681e-02 1.196 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.138642e-02 1.212 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.792228e-02 1.237 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 7.309815e-02 1.136 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 7.309815e-02 1.136 0 0
Orc1 removal from chromatin R-HSA-68949 7.517137e-02 1.124 0 0
Repression of WNT target genes R-HSA-4641265 7.184607e-02 1.144 0 0
MAPK family signaling cascades R-HSA-5683057 7.695035e-02 1.114 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.465720e-02 1.189 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.016711e-02 1.154 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.925957e-02 1.101 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.964487e-02 1.224 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.905243e-02 1.229 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.758321e-02 1.110 0 0
Signaling by FGFR3 R-HSA-5654741 6.620563e-02 1.179 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.792185e-02 1.237 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.480401e-02 1.126 0 0
Prolonged ERK activation events R-HSA-169893 6.018264e-02 1.221 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.197811e-02 1.086 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.620563e-02 1.179 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.620563e-02 1.179 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.758321e-02 1.110 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.670925e-02 1.176 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.184607e-02 1.144 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.184607e-02 1.144 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.812844e-02 1.236 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.291381e-02 1.137 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.136869e-02 1.146 0 0
Smooth Muscle Contraction R-HSA-445355 8.276114e-02 1.082 0 0
tRNA processing in the nucleus R-HSA-6784531 6.397073e-02 1.194 0 0
G1/S Transition R-HSA-69206 7.934114e-02 1.101 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.674879e-02 1.115 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.660832e-02 1.176 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.697154e-02 1.114 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.039145e-02 1.152 0 0
Base Excision Repair R-HSA-73884 6.006082e-02 1.221 0 0
Modulation by Mtb of host immune system R-HSA-9637628 6.670925e-02 1.176 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.365980e-02 1.077 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.365980e-02 1.077 0 0
HCMV Infection R-HSA-9609646 8.380318e-02 1.077 0 0
ALK mutants bind TKIs R-HSA-9700645 8.522981e-02 1.069 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.522981e-02 1.069 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.522981e-02 1.069 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.559990e-02 1.068 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.559990e-02 1.068 0 0
Degradation of DVL R-HSA-4641258 8.613291e-02 1.065 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.743624e-02 1.058 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.743624e-02 1.058 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.743624e-02 1.058 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.860821e-02 1.053 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.860821e-02 1.053 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.071218e-02 1.042 0 0
Translation initiation complex formation R-HSA-72649 9.081881e-02 1.042 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.081881e-02 1.042 0 0
Signaling by Hedgehog R-HSA-5358351 9.101680e-02 1.041 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.114968e-02 1.040 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.114968e-02 1.040 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.114968e-02 1.040 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.114968e-02 1.040 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.114968e-02 1.040 0 0
Activation of ATR in response to replication stress R-HSA-176187 9.309485e-02 1.031 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 9.309485e-02 1.031 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.459573e-02 1.024 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.624166e-02 1.017 0 0
Defective pyroptosis R-HSA-9710421 9.791005e-02 1.009 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.893875e-02 1.005 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.893875e-02 1.005 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 9.902268e-02 1.004 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 9.902268e-02 1.004 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 9.902268e-02 1.004 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.902268e-02 1.004 0 0
GAB1 signalosome R-HSA-180292 1.002118e-01 0.999 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.004937e-01 0.998 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.009351e-01 0.996 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.046368e-01 0.980 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.046368e-01 0.980 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.046368e-01 0.980 0 0
Signaling by FGFR2 R-HSA-5654738 1.046369e-01 0.980 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.053033e-01 0.978 0 0
Regulation of TP53 Expression R-HSA-6804754 1.053033e-01 0.978 0 0
C6 deamination of adenosine R-HSA-75102 1.053033e-01 0.978 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.053033e-01 0.978 0 0
Signaling by FGFR in disease R-HSA-1226099 1.059166e-01 0.975 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.059672e-01 0.975 0 0
Regulation of CDH11 function R-HSA-9762292 1.059672e-01 0.975 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.059672e-01 0.975 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.066277e-01 0.972 0 0
Signaling by ALK R-HSA-201556 1.066277e-01 0.972 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.066277e-01 0.972 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.078380e-01 0.967 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.084127e-01 0.965 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.132270e-01 0.946 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.132270e-01 0.946 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.132270e-01 0.946 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.162226e-01 0.935 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.168251e-01 0.932 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.178371e-01 0.929 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.178371e-01 0.929 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.184725e-01 0.926 0 0
DCC mediated attractive signaling R-HSA-418885 1.233676e-01 0.909 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.233676e-01 0.909 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.233676e-01 0.909 0 0
p38MAPK events R-HSA-171007 1.233676e-01 0.909 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.233676e-01 0.909 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.233676e-01 0.909 0 0
Translesion synthesis by REV1 R-HSA-110312 1.233676e-01 0.909 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.233676e-01 0.909 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.233676e-01 0.909 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.245003e-01 0.905 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.267885e-01 0.897 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.267885e-01 0.897 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.267885e-01 0.897 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.277311e-01 0.894 0 0
Signaling by LTK in cancer R-HSA-9842640 1.280572e-01 0.893 0 0
Nef and signal transduction R-HSA-164944 1.280572e-01 0.893 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.281899e-01 0.892 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.281899e-01 0.892 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.281899e-01 0.892 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.281899e-01 0.892 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.281899e-01 0.892 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.281899e-01 0.892 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.281899e-01 0.892 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.281899e-01 0.892 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.281899e-01 0.892 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.281899e-01 0.892 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.281899e-01 0.892 0 0
Potential therapeutics for SARS R-HSA-9679191 1.283069e-01 0.892 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 1.287444e-01 0.890 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 1.287444e-01 0.890 1 1
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.288651e-01 0.890 0 0
Regulation of Apoptosis R-HSA-169911 1.288651e-01 0.890 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.288931e-01 0.890 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.296746e-01 0.887 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.296746e-01 0.887 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.330528e-01 0.876 0 0
Signaling by ROBO receptors R-HSA-376176 1.359524e-01 0.867 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.384153e-01 0.859 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.384153e-01 0.859 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 1.384153e-01 0.859 0 0
MHC class II antigen presentation R-HSA-2132295 1.387395e-01 0.858 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.411521e-01 0.850 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.411521e-01 0.850 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.421257e-01 0.847 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.422022e-01 0.847 0 0
RNA Polymerase III Transcription R-HSA-74158 1.422022e-01 0.847 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.422022e-01 0.847 0 0
Translesion synthesis by POLI R-HSA-5656121 1.435275e-01 0.843 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.435275e-01 0.843 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.399536e-01 0.620 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.399536e-01 0.620 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.399536e-01 0.620 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.399536e-01 0.620 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.399536e-01 0.620 0 0
Hereditary fructose intolerance R-HSA-5657560 2.399536e-01 0.620 0 0
UNC93B1 deficiency - HSE R-HSA-5602415 2.399536e-01 0.620 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.399536e-01 0.620 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.399536e-01 0.620 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.399536e-01 0.620 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.399536e-01 0.620 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.399536e-01 0.620 0 0
TRKA activation by NGF R-HSA-187042 1.509009e-01 0.821 0 0
PLC-gamma1 signalling R-HSA-167021 1.509009e-01 0.821 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.509009e-01 0.821 0 0
MET interacts with TNS proteins R-HSA-8875513 1.509009e-01 0.821 0 0
Regulation of gap junction activity R-HSA-191650 1.995139e-01 0.700 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.995139e-01 0.700 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.995139e-01 0.700 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.995139e-01 0.700 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.995139e-01 0.700 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.596812e-01 0.797 0 0
NrCAM interactions R-HSA-447038 2.496208e-01 0.603 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.496208e-01 0.603 0 0
IRS activation R-HSA-74713 2.496208e-01 0.603 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.496208e-01 0.603 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.496208e-01 0.603 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.496208e-01 0.603 0 0
Type I hemidesmosome assembly R-HSA-446107 1.933668e-01 0.714 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.933668e-01 0.714 0 0
Formation of annular gap junctions R-HSA-196025 1.933668e-01 0.714 0 0
Activation of RAC1 R-HSA-428540 1.533525e-01 0.814 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.795613e-01 0.746 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.795613e-01 0.746 0 0
Lipophagy R-HSA-9613354 2.286000e-01 0.641 0 0
Gap junction degradation R-HSA-190873 2.286000e-01 0.641 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.649981e-01 0.783 0 0
Translesion synthesis by POLK R-HSA-5655862 1.649981e-01 0.783 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.649981e-01 0.783 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.511644e-01 0.821 0 0
2-LTR circle formation R-HSA-164843 2.648964e-01 0.577 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.648964e-01 0.577 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.648964e-01 0.577 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.876478e-01 0.727 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.703056e-01 0.769 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.113352e-01 0.675 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.903913e-01 0.720 0 0
Notch-HLH transcription pathway R-HSA-350054 1.903913e-01 0.720 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.903913e-01 0.720 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.722184e-01 0.764 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.722184e-01 0.764 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.722184e-01 0.764 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 2.653428e-01 0.576 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.653428e-01 0.576 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.653428e-01 0.576 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 2.113290e-01 0.675 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.113290e-01 0.675 0 0
HIV elongation arrest and recovery R-HSA-167287 1.903405e-01 0.720 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.903405e-01 0.720 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.551720e-01 0.809 0 0
MET promotes cell motility R-HSA-8875878 1.708599e-01 0.767 0 0
Striated Muscle Contraction R-HSA-390522 1.887028e-01 0.724 0 0
Deadenylation of mRNA R-HSA-429947 2.330206e-01 0.633 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.612286e-01 0.583 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.019529e-01 0.695 0 0
PERK regulates gene expression R-HSA-381042 2.236798e-01 0.650 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.694089e-01 0.570 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.351807e-01 0.629 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.351807e-01 0.629 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.206406e-01 0.656 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.554156e-01 0.593 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.554156e-01 0.593 0 0
HIV Transcription Elongation R-HSA-167169 2.019529e-01 0.695 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.158741e-01 0.666 0 0
G0 and Early G1 R-HSA-1538133 2.694089e-01 0.570 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.286000e-01 0.641 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.019529e-01 0.695 0 0
HSF1-dependent transactivation R-HSA-3371571 1.931553e-01 0.714 0 0
Signaling by PDGF R-HSA-186797 1.718931e-01 0.765 0 0
Disorders of Developmental Biology R-HSA-9675151 1.649981e-01 0.783 0 0
MAP2K and MAPK activation R-HSA-5674135 2.351807e-01 0.629 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.439779e-01 0.613 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.795092e-01 0.554 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.782563e-01 0.556 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.649981e-01 0.783 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.496208e-01 0.603 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 2.286000e-01 0.641 0 0
Polo-like kinase mediated events R-HSA-156711 2.113352e-01 0.675 0 0
Nuclear RNA decay R-HSA-9930044 1.721498e-01 0.764 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.861196e-01 0.730 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.931553e-01 0.714 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.912297e-01 0.718 0 0
Downstream TCR signaling R-HSA-202424 2.083387e-01 0.681 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.169532e-01 0.664 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.058966e-01 0.686 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.817399e-01 0.741 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.566893e-01 0.591 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.995139e-01 0.700 0 0
Budding and maturation of HIV virion R-HSA-162588 2.488002e-01 0.604 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.206406e-01 0.656 0 0
Generic Transcription Pathway R-HSA-212436 2.641689e-01 0.578 1 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.782563e-01 0.556 0 0
Signal attenuation R-HSA-74749 2.648964e-01 0.577 0 0
Signaling by NOTCH4 R-HSA-9013694 1.641104e-01 0.785 0 0
Regulated Necrosis R-HSA-5218859 2.500193e-01 0.602 0 0
Pyrophosphate hydrolysis R-HSA-71737 2.496208e-01 0.603 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.649981e-01 0.783 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 1.876478e-01 0.727 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.721498e-01 0.764 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.562100e-01 0.806 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.236798e-01 0.650 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.183206e-01 0.661 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.183206e-01 0.661 0 0
Cellular response to hypoxia R-HSA-1234174 2.093522e-01 0.679 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.330206e-01 0.633 0 0
Degradation of AXIN R-HSA-4641257 1.562100e-01 0.806 0 0
Signaling by WNT R-HSA-195721 1.830022e-01 0.738 0 0
CHL1 interactions R-HSA-447041 1.596812e-01 0.797 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.782563e-01 0.556 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.266305e-01 0.645 0 0
Signaling by NOTCH2 R-HSA-1980145 2.058966e-01 0.686 0 0
Toll-like Receptor Cascades R-HSA-168898 1.873633e-01 0.727 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.782563e-01 0.556 0 0
Interleukin-1 signaling R-HSA-9020702 1.452804e-01 0.838 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.687917e-01 0.773 0 0
ERK/MAPK targets R-HSA-198753 2.871325e-01 0.542 0 0
TBC/RABGAPs R-HSA-8854214 2.701991e-01 0.568 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.649981e-01 0.783 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.359124e-01 0.627 0 0
Signaling by FGFR1 R-HSA-5654736 1.757282e-01 0.755 0 0
G1 Phase R-HSA-69236 1.829598e-01 0.738 0 0
Cyclin D associated events in G1 R-HSA-69231 1.829598e-01 0.738 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.703056e-01 0.769 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.721498e-01 0.764 0 0
SDK interactions R-HSA-373756 2.399536e-01 0.620 0 0
MTF1 activates gene expression R-HSA-5660489 1.995139e-01 0.700 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.995139e-01 0.700 0 0
Co-stimulation by ICOS R-HSA-9927354 1.933668e-01 0.714 0 0
Signaling by LTK R-HSA-9842663 1.795613e-01 0.746 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.286000e-01 0.641 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.648964e-01 0.577 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.703056e-01 0.769 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.903405e-01 0.720 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.091918e-01 0.679 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.058966e-01 0.686 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.976485e-01 0.704 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.976485e-01 0.704 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.602046e-01 0.795 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.607937e-01 0.584 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.800085e-01 0.553 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.871325e-01 0.542 0 0
NGF-stimulated transcription R-HSA-9031628 2.445191e-01 0.612 0 0
Developmental Biology R-HSA-1266738 1.723549e-01 0.764 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.286000e-01 0.641 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.721498e-01 0.764 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.236798e-01 0.650 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.596812e-01 0.797 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.887028e-01 0.724 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.058966e-01 0.686 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.609608e-01 0.583 0 0
Frs2-mediated activation R-HSA-170968 2.071278e-01 0.684 0 0
Formation of definitive endoderm R-HSA-9823730 2.612286e-01 0.583 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.058966e-01 0.686 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.003120e-01 0.698 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.160757e-01 0.665 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.113352e-01 0.675 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.488002e-01 0.604 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.185678e-01 0.660 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.795613e-01 0.746 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.795613e-01 0.746 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.871325e-01 0.542 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.505884e-01 0.601 0 0
Assembly Of The HIV Virion R-HSA-175474 1.703056e-01 0.769 0 0
Inositol phosphate metabolism R-HSA-1483249 2.638846e-01 0.579 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.871325e-01 0.542 0 0
Signal regulatory protein family interactions R-HSA-391160 2.358038e-01 0.627 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.871325e-01 0.542 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.596812e-01 0.797 0 0
Signaling by Interleukins R-HSA-449147 2.586099e-01 0.587 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.649981e-01 0.783 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.128269e-01 0.672 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.661824e-01 0.779 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.800085e-01 0.553 0 0
IRE1alpha activates chaperones R-HSA-381070 1.619499e-01 0.791 0 0
Interleukin-7 signaling R-HSA-1266695 2.553644e-01 0.593 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.513639e-01 0.820 0 0
Netrin-1 signaling R-HSA-373752 2.882638e-01 0.540 0 0
DAP12 interactions R-HSA-2172127 2.882638e-01 0.540 0 0
IGF1R signaling cascade R-HSA-2428924 2.890316e-01 0.539 0 0
Ion transport by P-type ATPases R-HSA-936837 2.890316e-01 0.539 0 0
Integrin signaling R-HSA-354192 2.904515e-01 0.537 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.904515e-01 0.537 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.904515e-01 0.537 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.904515e-01 0.537 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.921292e-01 0.534 0 0
Hedgehog 'on' state R-HSA-5632684 2.933158e-01 0.533 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.948442e-01 0.530 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.948442e-01 0.530 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.955043e-01 0.529 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 2.955043e-01 0.529 0 0
Phosphorylation of the APC/C R-HSA-176412 2.955043e-01 0.529 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.955043e-01 0.529 0 0
Adaptive Immune System R-HSA-1280218 2.969298e-01 0.527 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.969372e-01 0.527 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.000404e-01 0.523 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.000404e-01 0.523 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.000404e-01 0.523 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.000404e-01 0.523 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.000404e-01 0.523 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.006102e-01 0.522 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.015918e-01 0.521 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.015918e-01 0.521 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.015918e-01 0.521 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.018106e-01 0.520 0 0
Bicarbonate transporters R-HSA-425381 3.018106e-01 0.520 0 0
Circadian clock R-HSA-9909396 3.023733e-01 0.519 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.045727e-01 0.516 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.045727e-01 0.516 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.066342e-01 0.513 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.112766e-01 0.507 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.118502e-01 0.506 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.122063e-01 0.506 0 0
Platelet degranulation R-HSA-114608 3.123823e-01 0.505 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.133218e-01 0.504 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.134748e-01 0.504 0 0
Diseases of DNA repair R-HSA-9675135 3.252614e-01 0.488 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.252668e-01 0.488 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.252668e-01 0.488 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.252668e-01 0.488 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.260591e-01 0.487 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.297944e-01 0.482 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.309864e-01 0.480 0 0
Signaling by FGFR R-HSA-190236 3.309864e-01 0.480 0 0
RAF activation R-HSA-5673000 3.335272e-01 0.477 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.335272e-01 0.477 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.335272e-01 0.477 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.373952e-01 0.472 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.373952e-01 0.472 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 3.373952e-01 0.472 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.373952e-01 0.472 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 3.373952e-01 0.472 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.373952e-01 0.472 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.373952e-01 0.472 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.373952e-01 0.472 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.373952e-01 0.472 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.373952e-01 0.472 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.373952e-01 0.472 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.373952e-01 0.472 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.373952e-01 0.472 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.389419e-01 0.470 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 3.389419e-01 0.470 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.389419e-01 0.470 0 0
Integration of provirus R-HSA-162592 3.389419e-01 0.470 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.389419e-01 0.470 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.389419e-01 0.470 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.395618e-01 0.469 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.395618e-01 0.469 0 0
FGFR2 alternative splicing R-HSA-6803529 3.401107e-01 0.468 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.491792e-01 0.457 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.498694e-01 0.456 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.498694e-01 0.456 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.498694e-01 0.456 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.498694e-01 0.456 0 0
Neurofascin interactions R-HSA-447043 3.498694e-01 0.456 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.498694e-01 0.456 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.498694e-01 0.456 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.502579e-01 0.456 0 0
Vesicle-mediated transport R-HSA-5653656 3.533724e-01 0.452 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.539971e-01 0.451 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.567916e-01 0.448 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.567916e-01 0.448 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.567916e-01 0.448 0 0
Glycogen storage diseases R-HSA-3229121 3.567916e-01 0.448 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.570079e-01 0.447 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.581871e-01 0.446 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.598471e-01 0.444 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.598471e-01 0.444 0 0
Co-stimulation by CD28 R-HSA-389356 3.630889e-01 0.440 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.633259e-01 0.440 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.669008e-01 0.435 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.669008e-01 0.435 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.669008e-01 0.435 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.669008e-01 0.435 0 0
Syndecan interactions R-HSA-3000170 3.669008e-01 0.435 0 0
ER-Phagosome pathway R-HSA-1236974 3.706315e-01 0.431 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.732301e-01 0.428 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.732301e-01 0.428 0 0
Activation of BH3-only proteins R-HSA-114452 3.732301e-01 0.428 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.759365e-01 0.425 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.759365e-01 0.425 0 0
Polymerase switching R-HSA-69091 3.759365e-01 0.425 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 3.759365e-01 0.425 0 0
Leading Strand Synthesis R-HSA-69109 3.759365e-01 0.425 0 0
GRB2 events in EGFR signaling R-HSA-179812 3.759365e-01 0.425 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 3.759365e-01 0.425 0 0
MET activates RAS signaling R-HSA-8851805 3.759365e-01 0.425 0 0
GPVI-mediated activation cascade R-HSA-114604 3.774113e-01 0.423 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.840869e-01 0.416 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.875024e-01 0.412 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.875024e-01 0.412 0 0
Mismatch Repair R-HSA-5358508 3.875024e-01 0.412 0 0
Tie2 Signaling R-HSA-210993 3.875024e-01 0.412 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.937135e-01 0.405 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.954880e-01 0.403 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.963857e-01 0.402 0 0
Trafficking of AMPA receptors R-HSA-399719 3.973240e-01 0.401 0 0
Activation of TRKA receptors R-HSA-187015 3.984311e-01 0.400 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.984311e-01 0.400 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.984311e-01 0.400 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.984311e-01 0.400 0 0
Recycling of eIF2:GDP R-HSA-72731 3.984311e-01 0.400 0 0
Netrin mediated repulsion signals R-HSA-418886 3.984311e-01 0.400 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.984311e-01 0.400 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.984311e-01 0.400 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.988744e-01 0.399 0 0
PCP/CE pathway R-HSA-4086400 4.008182e-01 0.397 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.012551e-01 0.397 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.013566e-01 0.396 0 0
IRS-mediated signalling R-HSA-112399 4.015905e-01 0.396 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.124883e-01 0.385 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.124883e-01 0.385 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.124883e-01 0.385 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.124883e-01 0.385 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.180096e-01 0.379 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.196996e-01 0.377 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.205974e-01 0.376 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.211762e-01 0.376 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.223492e-01 0.374 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.223492e-01 0.374 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.223492e-01 0.374 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.223492e-01 0.374 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.223492e-01 0.374 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.223492e-01 0.374 0 0
DSCAM interactions R-HSA-376172 4.223492e-01 0.374 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.223492e-01 0.374 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.223492e-01 0.374 0 0
Synthesis and processing of ENV and VPU R-HSA-171286 4.223492e-01 0.374 0 0
Peroxisomal protein import R-HSA-9033241 4.377952e-01 0.359 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.377952e-01 0.359 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.415899e-01 0.355 0 0
RAS processing R-HSA-9648002 4.434721e-01 0.353 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.452315e-01 0.351 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.452315e-01 0.351 0 0
MET receptor recycling R-HSA-8875656 4.452315e-01 0.351 0 0
Regulation by c-FLIP R-HSA-3371378 4.452315e-01 0.351 0 0
Sodium/Proton exchangers R-HSA-425986 4.452315e-01 0.351 0 0
Dimerization of procaspase-8 R-HSA-69416 4.452315e-01 0.351 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.452315e-01 0.351 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.452315e-01 0.351 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.452844e-01 0.351 0 0
Cardiogenesis R-HSA-9733709 4.452844e-01 0.351 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.469226e-01 0.350 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.479855e-01 0.349 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.481502e-01 0.349 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.481502e-01 0.349 0 0
Glycogen synthesis R-HSA-3322077 4.481502e-01 0.349 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.483375e-01 0.348 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.483375e-01 0.348 0 0
ABC-family proteins mediated transport R-HSA-382556 4.552214e-01 0.342 0 0
Glycolysis R-HSA-70171 4.552214e-01 0.342 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.619008e-01 0.335 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.652850e-01 0.332 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.652850e-01 0.332 0 0
Diseases of Immune System R-HSA-5260271 4.652850e-01 0.332 0 0
Interleukin-2 family signaling R-HSA-451927 4.652850e-01 0.332 0 0
Transcription of the HIV genome R-HSA-167172 4.701792e-01 0.328 0 0
Interleukin-1 family signaling R-HSA-446652 4.715351e-01 0.326 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.731006e-01 0.325 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.747935e-01 0.323 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.766784e-01 0.322 0 0
Lagging Strand Synthesis R-HSA-69186 4.777795e-01 0.321 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.777795e-01 0.321 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 4.777795e-01 0.321 0 0
Interleukin-12 signaling R-HSA-9020591 4.830857e-01 0.316 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.832678e-01 0.316 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.832678e-01 0.316 0 0
Protein methylation R-HSA-8876725 4.832678e-01 0.316 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.832678e-01 0.316 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.870791e-01 0.312 0 0
ARMS-mediated activation R-HSA-170984 4.899242e-01 0.310 0 0
WNT mediated activation of DVL R-HSA-201688 4.899242e-01 0.310 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.899242e-01 0.310 0 0
Calcineurin activates NFAT R-HSA-2025928 4.899242e-01 0.310 0 0
CASP8 activity is inhibited R-HSA-5218900 4.899242e-01 0.310 0 0
mRNA Editing R-HSA-75072 4.899242e-01 0.310 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.899242e-01 0.310 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.899242e-01 0.310 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.899242e-01 0.310 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.899242e-01 0.310 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.899242e-01 0.310 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.899242e-01 0.310 0 0
FasL/ CD95L signaling R-HSA-75157 4.964154e-01 0.304 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.964154e-01 0.304 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.964154e-01 0.304 0 0
MET activates PTPN11 R-HSA-8865999 4.964154e-01 0.304 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.964154e-01 0.304 0 0
Signalling to STAT3 R-HSA-198745 4.964154e-01 0.304 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.964154e-01 0.304 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.964154e-01 0.304 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.964154e-01 0.304 0 0
Expression and Processing of Neurotrophins R-HSA-9036866 4.964154e-01 0.304 0 0
NGF processing R-HSA-167060 4.964154e-01 0.304 0 0
Signaling by NOTCH3 R-HSA-9012852 4.965453e-01 0.304 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.992546e-01 0.302 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.067720e-01 0.295 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.082387e-01 0.294 0 0
HIV Transcription Initiation R-HSA-167161 5.082387e-01 0.294 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.082387e-01 0.294 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.151671e-01 0.288 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.154645e-01 0.288 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.154645e-01 0.288 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.154645e-01 0.288 0 0
SARS-CoV Infections R-HSA-9679506 5.164817e-01 0.287 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.171039e-01 0.286 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.171039e-01 0.286 0 0
Killing mechanisms R-HSA-9664420 5.171039e-01 0.286 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.171039e-01 0.286 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.203955e-01 0.284 0 0
mRNA Capping R-HSA-72086 5.241327e-01 0.281 0 0
Insulin receptor signalling cascade R-HSA-74751 5.268286e-01 0.278 0 0
Mitochondrial biogenesis R-HSA-1592230 5.289610e-01 0.277 0 0
Ca-dependent events R-HSA-111996 5.292736e-01 0.276 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.322803e-01 0.274 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.322803e-01 0.274 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.322803e-01 0.274 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 5.322803e-01 0.274 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.322803e-01 0.274 0 0
Signaling by Leptin R-HSA-2586552 5.322803e-01 0.274 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.350199e-01 0.272 1 1
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.350199e-01 0.272 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.350199e-01 0.272 0 0
RUNX2 regulates bone development R-HSA-8941326 5.381136e-01 0.269 0 0
HSF1 activation R-HSA-3371511 5.381136e-01 0.269 0 0
Calmodulin induced events R-HSA-111933 5.381136e-01 0.269 0 0
CaM pathway R-HSA-111997 5.381136e-01 0.269 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.403517e-01 0.267 0 0
PI3K Cascade R-HSA-109704 5.411798e-01 0.267 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.488291e-01 0.261 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.495739e-01 0.260 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.495739e-01 0.260 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.495739e-01 0.260 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.497075e-01 0.260 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.497075e-01 0.260 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.499507e-01 0.260 0 0
Ribosome-associated quality control R-HSA-9948299 5.521831e-01 0.258 0 0
Interleukin-12 family signaling R-HSA-447115 5.557520e-01 0.255 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.609886e-01 0.251 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.609886e-01 0.251 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.609886e-01 0.251 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.609886e-01 0.251 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.609886e-01 0.251 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.609886e-01 0.251 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.609886e-01 0.251 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.609886e-01 0.251 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.609886e-01 0.251 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.609886e-01 0.251 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.609886e-01 0.251 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.624331e-01 0.250 0 0
Growth hormone receptor signaling R-HSA-982772 5.624331e-01 0.250 0 0
Ion channel transport R-HSA-983712 5.655140e-01 0.248 0 0
RMTs methylate histone arginines R-HSA-3214858 5.702280e-01 0.244 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.721643e-01 0.242 0 0
Signaling by APC mutants R-HSA-4839744 5.721643e-01 0.242 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.721643e-01 0.242 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.721643e-01 0.242 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.721643e-01 0.242 0 0
Dissolution of Fibrin Clot R-HSA-75205 5.721643e-01 0.242 0 0
Formation of the posterior neural plate R-HSA-9832991 5.721643e-01 0.242 0 0
Synthesis of PI R-HSA-1483226 5.721643e-01 0.242 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.721643e-01 0.242 0 0
Interleukin-2 signaling R-HSA-9020558 5.721643e-01 0.242 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 5.728906e-01 0.242 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.739511e-01 0.241 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.790713e-01 0.237 1 0
Neurexins and neuroligins R-HSA-6794361 5.790713e-01 0.237 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.809737e-01 0.236 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.809737e-01 0.236 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.889379e-01 0.230 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.889379e-01 0.230 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.889379e-01 0.230 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.900683e-01 0.229 0 0
DAG and IP3 signaling R-HSA-1489509 5.900683e-01 0.229 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.030678e-01 0.220 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.043062e-01 0.219 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.094385e-01 0.215 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.095138e-01 0.215 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.095138e-01 0.215 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.095138e-01 0.215 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.095138e-01 0.215 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.095138e-01 0.215 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.095138e-01 0.215 0 0
Signaling by AXIN mutants R-HSA-4839735 6.095138e-01 0.215 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.095138e-01 0.215 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.095138e-01 0.215 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 6.108276e-01 0.214 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.108276e-01 0.214 0 0
Platelet sensitization by LDL R-HSA-432142 6.108276e-01 0.214 0 0
Apoptotic factor-mediated response R-HSA-111471 6.108276e-01 0.214 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.119255e-01 0.213 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.144759e-01 0.211 0 0
Tight junction interactions R-HSA-420029 6.144759e-01 0.211 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.144759e-01 0.211 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.144759e-01 0.211 0 0
Reelin signalling pathway R-HSA-8866376 6.172850e-01 0.210 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.172850e-01 0.210 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.172850e-01 0.210 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.172850e-01 0.210 0 0
Activation of AKT2 R-HSA-165158 6.172850e-01 0.210 0 0
PTK6 Down-Regulation R-HSA-8849472 6.172850e-01 0.210 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.172850e-01 0.210 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.172850e-01 0.210 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.172850e-01 0.210 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.172850e-01 0.210 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 6.172850e-01 0.210 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.211270e-01 0.207 0 0
Attenuation phase R-HSA-3371568 6.235827e-01 0.205 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.294309e-01 0.201 0 0
ABC transporter disorders R-HSA-5619084 6.317028e-01 0.199 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.390028e-01 0.194 0 0
Suppression of phagosomal maturation R-HSA-9637687 6.390028e-01 0.194 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.392201e-01 0.194 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.392201e-01 0.194 0 0
The NLRP3 inflammasome R-HSA-844456 6.392201e-01 0.194 0 0
Other interleukin signaling R-HSA-449836 6.392201e-01 0.194 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.407695e-01 0.193 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.407695e-01 0.193 0 0
Signaling by Insulin receptor R-HSA-74752 6.414073e-01 0.193 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.443229e-01 0.191 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.443229e-01 0.191 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.443229e-01 0.191 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.443229e-01 0.191 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.443229e-01 0.191 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.443229e-01 0.191 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.443229e-01 0.191 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.443229e-01 0.191 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 6.443229e-01 0.191 0 0
Regulation of IFNG signaling R-HSA-877312 6.443229e-01 0.191 0 0
Interleukin-15 signaling R-HSA-8983432 6.443229e-01 0.191 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 6.443229e-01 0.191 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.500876e-01 0.187 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.624875e-01 0.179 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.624875e-01 0.179 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.627214e-01 0.179 0 0
Translation of Structural Proteins R-HSA-9683701 6.627214e-01 0.179 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.646445e-01 0.177 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.661248e-01 0.176 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.661248e-01 0.176 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.661248e-01 0.176 0 0
Signal transduction by L1 R-HSA-445144 6.661248e-01 0.176 0 0
Signaling by NODAL R-HSA-1181150 6.661248e-01 0.176 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.661248e-01 0.176 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.663651e-01 0.176 0 0
NGF-independant TRKA activation R-HSA-187024 6.663651e-01 0.176 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.663651e-01 0.176 0 0
Cam-PDE 1 activation R-HSA-111957 6.663651e-01 0.176 0 0
Phosphorylation of Emi1 R-HSA-176417 6.663651e-01 0.176 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.663651e-01 0.176 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.663651e-01 0.176 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.663651e-01 0.176 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.663651e-01 0.176 0 0
PDE3B signalling R-HSA-165160 6.663651e-01 0.176 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.663651e-01 0.176 0 0
PKB-mediated events R-HSA-109703 6.663651e-01 0.176 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.663651e-01 0.176 0 0
Synthesis of PS R-HSA-1483101 6.663651e-01 0.176 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.663651e-01 0.176 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.663651e-01 0.176 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.663651e-01 0.176 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.663651e-01 0.176 0 0
Relaxin receptors R-HSA-444821 6.663651e-01 0.176 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.663651e-01 0.176 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.663651e-01 0.176 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.663651e-01 0.176 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.663651e-01 0.176 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.667152e-01 0.176 1 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.675161e-01 0.176 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.677417e-01 0.175 0 0
Ca2+ pathway R-HSA-4086398 6.720358e-01 0.173 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.749132e-01 0.171 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 6.766289e-01 0.170 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.766289e-01 0.170 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.766289e-01 0.170 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 6.766289e-01 0.170 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.766289e-01 0.170 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.766289e-01 0.170 0 0
Cellular response to chemical stress R-HSA-9711123 6.782545e-01 0.169 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.847331e-01 0.164 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.849101e-01 0.164 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.849101e-01 0.164 0 0
HCMV Late Events R-HSA-9610379 6.876990e-01 0.163 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.915345e-01 0.160 0 0
Basigin interactions R-HSA-210991 6.915345e-01 0.160 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.974251e-01 0.157 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.020033e-01 0.154 0 0
Removal of the Flap Intermediate R-HSA-69166 7.065012e-01 0.151 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.091535e-01 0.149 0 0
STAT5 Activation R-HSA-9645135 7.091535e-01 0.149 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.091535e-01 0.149 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.091535e-01 0.149 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 7.091535e-01 0.149 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.091535e-01 0.149 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.091535e-01 0.149 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 7.091535e-01 0.149 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.091535e-01 0.149 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.091535e-01 0.149 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.091535e-01 0.149 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.091535e-01 0.149 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.091535e-01 0.149 0 0
Lipid particle organization R-HSA-8964572 7.091535e-01 0.149 0 0
Rab regulation of trafficking R-HSA-9007101 7.119821e-01 0.148 0 0
Glucose metabolism R-HSA-70326 7.119821e-01 0.148 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.136063e-01 0.147 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.138287e-01 0.146 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.154583e-01 0.145 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.154583e-01 0.145 0 0
Attachment and Entry R-HSA-9694614 7.154583e-01 0.145 0 0
Viral Infection Pathways R-HSA-9824446 7.154615e-01 0.145 0 0
Proteasome assembly R-HSA-9907900 7.164187e-01 0.145 0 0
Muscle contraction R-HSA-397014 7.173164e-01 0.144 0 0
RSV-host interactions R-HSA-9833110 7.192063e-01 0.143 0 0
Interleukin-37 signaling R-HSA-9008059 7.265408e-01 0.139 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.274882e-01 0.138 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.276544e-01 0.138 0 0
PLC beta mediated events R-HSA-112043 7.282838e-01 0.138 0 0
Post-translational protein modification R-HSA-597592 7.317482e-01 0.136 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.332054e-01 0.135 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.340327e-01 0.134 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.340327e-01 0.134 0 0
Biotin transport and metabolism R-HSA-196780 7.340327e-01 0.134 0 0
Formation of the anterior neural plate R-HSA-9823739 7.340327e-01 0.134 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.340327e-01 0.134 0 0
DNA Damage Reversal R-HSA-73942 7.340327e-01 0.134 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.379188e-01 0.132 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.379188e-01 0.132 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.379188e-01 0.132 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.379188e-01 0.132 0 0
FOXO-mediated transcription R-HSA-9614085 7.406193e-01 0.130 0 0
Transmission across Chemical Synapses R-HSA-112315 7.447014e-01 0.128 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 7.464566e-01 0.127 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.464566e-01 0.127 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.464566e-01 0.127 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 7.464566e-01 0.127 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.464566e-01 0.127 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.464566e-01 0.127 0 0
PTK6 Expression R-HSA-8849473 7.464566e-01 0.127 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.464566e-01 0.127 0 0
Disinhibition of SNARE formation R-HSA-114516 7.464566e-01 0.127 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.464566e-01 0.127 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.464566e-01 0.127 0 0
VLDL clearance R-HSA-8964046 7.464566e-01 0.127 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.464566e-01 0.127 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.464566e-01 0.127 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.547265e-01 0.122 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.593322e-01 0.120 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.593322e-01 0.120 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 7.593322e-01 0.120 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.593322e-01 0.120 0 0
Activation of SMO R-HSA-5635838 7.593322e-01 0.120 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.623534e-01 0.118 0 0
Stimuli-sensing channels R-HSA-2672351 7.623720e-01 0.118 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.639032e-01 0.117 0 0
Signaling by WNT in cancer R-HSA-4791275 7.639231e-01 0.117 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.639231e-01 0.117 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.707984e-01 0.113 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.707984e-01 0.113 0 0
Glycogen metabolism R-HSA-8982491 7.707984e-01 0.113 0 0
NRAGE signals death through JNK R-HSA-193648 7.729298e-01 0.112 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.778644e-01 0.109 0 0
Gluconeogenesis R-HSA-70263 7.783536e-01 0.109 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.785928e-01 0.109 0 0
phospho-PLA2 pathway R-HSA-111995 7.789771e-01 0.108 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.789771e-01 0.108 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.789771e-01 0.108 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.789771e-01 0.108 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.789771e-01 0.108 0 0
Activation of RAS in B cells R-HSA-1169092 7.789771e-01 0.108 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.789771e-01 0.108 0 0
Adrenoceptors R-HSA-390696 7.789771e-01 0.108 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.789771e-01 0.108 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.789771e-01 0.108 0 0
G-protein beta:gamma signalling R-HSA-397795 7.810611e-01 0.107 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 7.825194e-01 0.107 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 7.825194e-01 0.107 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 7.825194e-01 0.107 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.825194e-01 0.107 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.825194e-01 0.107 0 0
Response to metal ions R-HSA-5660526 7.825194e-01 0.107 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.968978e-01 0.099 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.968978e-01 0.099 0 0
Laminin interactions R-HSA-3000157 7.968978e-01 0.099 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.968978e-01 0.099 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.971958e-01 0.098 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.971958e-01 0.098 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.037198e-01 0.095 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.037198e-01 0.095 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.037198e-01 0.095 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.037198e-01 0.095 0 0
Specification of primordial germ cells R-HSA-9827857 8.037198e-01 0.095 0 0
G-protein mediated events R-HSA-112040 8.052795e-01 0.094 0 0
tRNA processing R-HSA-72306 8.072308e-01 0.093 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.073281e-01 0.093 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.073281e-01 0.093 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 8.073281e-01 0.093 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.073281e-01 0.093 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.073281e-01 0.093 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.073281e-01 0.093 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.073281e-01 0.093 0 0
Interleukin-1 processing R-HSA-448706 8.073281e-01 0.093 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.073281e-01 0.093 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.073281e-01 0.093 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.073281e-01 0.093 0 0
Extension of Telomeres R-HSA-180786 8.106371e-01 0.091 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.123567e-01 0.090 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.123567e-01 0.090 0 0
Signal amplification R-HSA-392518 8.123567e-01 0.090 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.123567e-01 0.090 0 0
MET activates PTK2 signaling R-HSA-8874081 8.139190e-01 0.089 0 0
TRP channels R-HSA-3295583 8.139190e-01 0.089 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.141800e-01 0.089 0 0
Influenza Infection R-HSA-168255 8.145721e-01 0.089 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.220743e-01 0.085 0 0
Translation of Structural Proteins R-HSA-9694635 8.221355e-01 0.085 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.230616e-01 0.085 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.230616e-01 0.085 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.246499e-01 0.084 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.270909e-01 0.082 0 0
G alpha (12/13) signalling events R-HSA-416482 8.319576e-01 0.080 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.320439e-01 0.080 0 0
Binding and entry of HIV virion R-HSA-173107 8.320439e-01 0.080 0 0
DNA replication initiation R-HSA-68952 8.320439e-01 0.080 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.320439e-01 0.080 0 0
Formation of apoptosome R-HSA-111458 8.320439e-01 0.080 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.320439e-01 0.080 0 0
Interleukin-27 signaling R-HSA-9020956 8.320439e-01 0.080 0 0
Maturation of spike protein R-HSA-9683686 8.320439e-01 0.080 0 0
G1/S-Specific Transcription R-HSA-69205 8.398899e-01 0.076 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.406725e-01 0.075 0 0
Rap1 signalling R-HSA-392517 8.406725e-01 0.075 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.406725e-01 0.075 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.406725e-01 0.075 0 0
Sensory processing of sound R-HSA-9659379 8.413538e-01 0.075 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.433181e-01 0.074 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.443444e-01 0.073 0 0
Insulin receptor recycling R-HSA-77387 8.443444e-01 0.073 0 0
Inflammasomes R-HSA-622312 8.443444e-01 0.073 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.504124e-01 0.070 0 0
Somitogenesis R-HSA-9824272 8.507235e-01 0.070 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.512949e-01 0.070 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.523343e-01 0.069 0 0
Adipogenesis R-HSA-9843745 8.530244e-01 0.069 0 0
vRNP Assembly R-HSA-192905 8.535904e-01 0.069 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.535904e-01 0.069 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.535904e-01 0.069 0 0
Prostanoid ligand receptors R-HSA-391908 8.535904e-01 0.069 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.578706e-01 0.067 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.583110e-01 0.066 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.614960e-01 0.065 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.623927e-01 0.064 0 0
Elastic fibre formation R-HSA-1566948 8.639477e-01 0.064 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.658768e-01 0.063 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.703553e-01 0.060 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.703553e-01 0.060 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.705193e-01 0.060 0 0
Ion homeostasis R-HSA-5578775 8.707501e-01 0.060 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.712009e-01 0.060 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.712009e-01 0.060 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.712009e-01 0.060 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.712009e-01 0.060 0 0
DS-GAG biosynthesis R-HSA-2022923 8.723739e-01 0.059 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.723739e-01 0.059 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.723739e-01 0.059 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.723739e-01 0.059 0 0
ERKs are inactivated R-HSA-202670 8.723739e-01 0.059 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.723739e-01 0.059 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.747691e-01 0.058 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.796743e-01 0.056 0 0
Metal ion SLC transporters R-HSA-425410 8.810880e-01 0.055 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.818602e-01 0.055 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.843574e-01 0.053 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.843574e-01 0.053 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.843574e-01 0.053 0 0
Serine metabolism R-HSA-977347 8.843574e-01 0.053 0 0
Developmental Cell Lineages R-HSA-9734767 8.846066e-01 0.053 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.880332e-01 0.052 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.887485e-01 0.051 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.887485e-01 0.051 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.887485e-01 0.051 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.887485e-01 0.051 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.887485e-01 0.051 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.887485e-01 0.051 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 8.887485e-01 0.051 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.887485e-01 0.051 0 0
Interleukin-35 Signalling R-HSA-8984722 8.887485e-01 0.051 0 0
OAS antiviral response R-HSA-8983711 8.887485e-01 0.051 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.909874e-01 0.050 0 0
Maturation of spike protein R-HSA-9694548 8.941931e-01 0.049 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.959130e-01 0.048 0 0
Protein localization R-HSA-9609507 8.960040e-01 0.048 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.962592e-01 0.048 0 0
Integrin cell surface interactions R-HSA-216083 9.018747e-01 0.045 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.028739e-01 0.044 0 0
Intra-Golgi traffic R-HSA-6811438 9.028739e-01 0.044 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 9.030230e-01 0.044 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 9.030230e-01 0.044 0 0
Processing of SMDT1 R-HSA-8949664 9.030230e-01 0.044 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.030230e-01 0.044 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 9.030230e-01 0.044 0 0
Maturation of nucleoprotein R-HSA-9683610 9.030230e-01 0.044 0 0
Interleukin-6 signaling R-HSA-1059683 9.030230e-01 0.044 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.030230e-01 0.044 0 0
tRNA Aminoacylation R-HSA-379724 9.033136e-01 0.044 0 0
PI Metabolism R-HSA-1483255 9.047273e-01 0.043 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.070115e-01 0.042 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.070115e-01 0.042 0 0
Formation of the ureteric bud R-HSA-9830674 9.070115e-01 0.042 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.070115e-01 0.042 0 0
Carnitine shuttle R-HSA-200425 9.070115e-01 0.042 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.070115e-01 0.042 0 0
Leishmania phagocytosis R-HSA-9664417 9.096421e-01 0.041 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.096421e-01 0.041 0 0
Parasite infection R-HSA-9664407 9.096421e-01 0.041 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.102565e-01 0.041 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.110977e-01 0.040 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.132407e-01 0.039 0 0
Peptide chain elongation R-HSA-156902 9.140991e-01 0.039 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.154668e-01 0.038 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.154668e-01 0.038 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 9.154668e-01 0.038 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.154668e-01 0.038 0 0
Hydrolysis of LPC R-HSA-1483115 9.154668e-01 0.038 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 9.154668e-01 0.038 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.154668e-01 0.038 0 0
Physiological factors R-HSA-5578768 9.154668e-01 0.038 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.154668e-01 0.038 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.154668e-01 0.038 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.154668e-01 0.038 0 0
Zinc transporters R-HSA-435354 9.154668e-01 0.038 0 0
P2Y receptors R-HSA-417957 9.154668e-01 0.038 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.154668e-01 0.038 0 0
Gastrulation R-HSA-9758941 9.162568e-01 0.038 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.167134e-01 0.038 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.167134e-01 0.038 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.167134e-01 0.038 0 0
Interleukin-6 family signaling R-HSA-6783589 9.167134e-01 0.038 0 0
Cellular response to starvation R-HSA-9711097 9.183704e-01 0.037 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.192762e-01 0.037 1 1
Hyaluronan degradation R-HSA-2160916 9.254574e-01 0.034 0 0
Protein lipoylation R-HSA-9857492 9.263144e-01 0.033 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.263144e-01 0.033 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.263144e-01 0.033 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.263144e-01 0.033 0 0
Signaling by Activin R-HSA-1502540 9.263144e-01 0.033 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.263144e-01 0.033 0 0
Other semaphorin interactions R-HSA-416700 9.263144e-01 0.033 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.294341e-01 0.032 0 0
Translation R-HSA-72766 9.299026e-01 0.032 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.301351e-01 0.031 0 0
Sphingolipid catabolism R-HSA-9845614 9.333294e-01 0.030 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.333294e-01 0.030 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.333294e-01 0.030 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.336049e-01 0.030 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.336049e-01 0.030 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.336049e-01 0.030 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.339909e-01 0.030 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.357705e-01 0.029 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 9.357705e-01 0.029 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.357705e-01 0.029 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.357705e-01 0.029 0 0
Fructose catabolism R-HSA-70350 9.357705e-01 0.029 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.357705e-01 0.029 0 0
Attachment and Entry R-HSA-9678110 9.357705e-01 0.029 0 0
Atorvastatin ADME R-HSA-9754706 9.357705e-01 0.029 0 0
Virus Assembly and Release R-HSA-168268 9.357705e-01 0.029 0 0
Iron uptake and transport R-HSA-917937 9.363910e-01 0.029 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.374674e-01 0.028 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.374674e-01 0.028 0 0
Neddylation R-HSA-8951664 9.384616e-01 0.028 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.388402e-01 0.027 0 0
Cristae formation R-HSA-8949613 9.404092e-01 0.027 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.404092e-01 0.027 0 0
Triglyceride biosynthesis R-HSA-75109 9.404092e-01 0.027 0 0
Insulin processing R-HSA-264876 9.404092e-01 0.027 0 0
Synthesis of PE R-HSA-1483213 9.404092e-01 0.027 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.434486e-01 0.025 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.434726e-01 0.025 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.440137e-01 0.025 0 0
Glycine degradation R-HSA-6783984 9.440137e-01 0.025 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.440137e-01 0.025 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.440137e-01 0.025 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.440137e-01 0.025 0 0
Synthesis of PG R-HSA-1483148 9.440137e-01 0.025 0 0
Telomere Extension By Telomerase R-HSA-171319 9.467705e-01 0.024 0 0
Pyroptosis R-HSA-5620971 9.467705e-01 0.024 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.507486e-01 0.022 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.511993e-01 0.022 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.511993e-01 0.022 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.511993e-01 0.022 0 0
Regulation of beta-cell development R-HSA-186712 9.514762e-01 0.022 0 0
Opioid Signalling R-HSA-111885 9.522473e-01 0.021 0 0
DARPP-32 events R-HSA-180024 9.524810e-01 0.021 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.524810e-01 0.021 0 0
Eukaryotic Translation Termination R-HSA-72764 9.531308e-01 0.021 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.574630e-01 0.019 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.574630e-01 0.019 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.574630e-01 0.019 0 0
PKA activation R-HSA-163615 9.574630e-01 0.019 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.574630e-01 0.019 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.574630e-01 0.019 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.576029e-01 0.019 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.595812e-01 0.018 0 0
Cargo concentration in the ER R-HSA-5694530 9.621933e-01 0.017 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.629231e-01 0.016 0 0
Pyrimidine biosynthesis R-HSA-500753 9.629231e-01 0.016 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.629231e-01 0.016 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.629231e-01 0.016 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.629231e-01 0.016 0 0
Specification of the neural plate border R-HSA-9834899 9.629231e-01 0.016 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.629231e-01 0.016 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.629231e-01 0.016 0 0
Maturation of nucleoprotein R-HSA-9694631 9.629231e-01 0.016 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.629231e-01 0.016 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.636412e-01 0.016 0 0
Interferon alpha/beta signaling R-HSA-909733 9.652884e-01 0.015 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.663042e-01 0.015 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.676826e-01 0.014 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.676826e-01 0.014 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.676826e-01 0.014 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.676826e-01 0.014 0 0
Protein hydroxylation R-HSA-9629569 9.676826e-01 0.014 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.676826e-01 0.014 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.686324e-01 0.014 0 0
Hemostasis R-HSA-109582 9.704188e-01 0.013 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.705705e-01 0.013 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.709317e-01 0.013 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.718314e-01 0.012 0 0
Abacavir metabolism R-HSA-2161541 9.718314e-01 0.012 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.718314e-01 0.012 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.718314e-01 0.012 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.732727e-01 0.012 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.744281e-01 0.011 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.744281e-01 0.011 0 0
CS-GAG biosynthesis R-HSA-2022870 9.754478e-01 0.011 0 0
Ribavirin ADME R-HSA-9755088 9.754478e-01 0.011 0 0
Glutathione synthesis and recycling R-HSA-174403 9.754478e-01 0.011 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.754502e-01 0.011 0 0
Integration of energy metabolism R-HSA-163685 9.758146e-01 0.011 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.762129e-01 0.010 0 0
Hyaluronan metabolism R-HSA-2142845 9.762129e-01 0.010 0 0
Immune System R-HSA-168256 9.784231e-01 0.009 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.786000e-01 0.009 0 0
Fructose metabolism R-HSA-5652084 9.786000e-01 0.009 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.788388e-01 0.009 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.788388e-01 0.009 0 0
Synthesis of PC R-HSA-1483191 9.805722e-01 0.009 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.807250e-01 0.008 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.807903e-01 0.008 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.813478e-01 0.008 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.813478e-01 0.008 0 0
Neutrophil degranulation R-HSA-6798695 9.813987e-01 0.008 0 0
SLC transporter disorders R-HSA-5619102 9.816805e-01 0.008 0 0
Neuronal System R-HSA-112316 9.833074e-01 0.007 0 0
Metabolism of polyamines R-HSA-351202 9.833511e-01 0.007 0 0
Complex III assembly R-HSA-9865881 9.837428e-01 0.007 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.851384e-01 0.007 0 0
Selenocysteine synthesis R-HSA-2408557 9.856745e-01 0.006 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.858305e-01 0.006 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.858305e-01 0.006 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.861616e-01 0.006 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.876501e-01 0.005 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.876501e-01 0.005 0 0
Urea cycle R-HSA-70635 9.876501e-01 0.005 0 0
Abacavir ADME R-HSA-2161522 9.876501e-01 0.005 0 0
Viral mRNA Translation R-HSA-192823 9.878220e-01 0.005 0 0
PPARA activates gene expression R-HSA-1989781 9.881135e-01 0.005 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.882800e-01 0.005 0 0
Parasitic Infection Pathways R-HSA-9824443 9.886437e-01 0.005 1 0
Leishmania infection R-HSA-9658195 9.886437e-01 0.005 1 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.892362e-01 0.005 0 0
Signaling by BMP R-HSA-201451 9.892362e-01 0.005 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.892362e-01 0.005 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.897933e-01 0.004 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.906186e-01 0.004 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.906186e-01 0.004 0 0
Pyrimidine salvage R-HSA-73614 9.906186e-01 0.004 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.907704e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.910118e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.917569e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.917932e-01 0.004 0 0
Platelet calcium homeostasis R-HSA-418360 9.918236e-01 0.004 0 0
Neurotransmitter release cycle R-HSA-112310 9.928041e-01 0.003 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.928739e-01 0.003 0 0
Neurotransmitter clearance R-HSA-112311 9.928739e-01 0.003 0 0
Dectin-2 family R-HSA-5621480 9.934117e-01 0.003 0 0
Surfactant metabolism R-HSA-5683826 9.935654e-01 0.003 0 0
Methylation R-HSA-156581 9.935654e-01 0.003 0 0
Amine ligand-binding receptors R-HSA-375280 9.935654e-01 0.003 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.935795e-01 0.003 0 0
COPII-mediated vesicle transport R-HSA-204005 9.939281e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.939281e-01 0.003 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.942978e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.945236e-01 0.002 0 0
HS-GAG degradation R-HSA-2024096 9.945871e-01 0.002 0 0
DAG1 glycosylations R-HSA-8931838 9.945871e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.947191e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.947191e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.947298e-01 0.002 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.952825e-01 0.002 0 0
CS/DS degradation R-HSA-2024101 9.958886e-01 0.002 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.958886e-01 0.002 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.958886e-01 0.002 0 0
Heme degradation R-HSA-189483 9.958886e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.960384e-01 0.002 0 0
Mitochondrial protein import R-HSA-1268020 9.962204e-01 0.002 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.964169e-01 0.002 0 0
eNOS activation R-HSA-203615 9.964169e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.964169e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.964169e-01 0.002 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.964290e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.964931e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.964931e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.965896e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.967543e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.968773e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.968964e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.972786e-01 0.001 0 0
Triglyceride catabolism R-HSA-163560 9.972786e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.976283e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.976283e-01 0.001 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.979331e-01 0.001 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.979331e-01 0.001 0 0
Purine salvage R-HSA-74217 9.979331e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.979396e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.981316e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.981988e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.981988e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.984303e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.984303e-01 0.001 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.985161e-01 0.001 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.986321e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.986380e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.988079e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.989612e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.989996e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.990219e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.990947e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.992111e-01 0.000 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.993125e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.993313e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.994009e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.994515e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.994884e-01 0.000 0 0
GPER1 signaling R-HSA-9634597 9.995451e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.995847e-01 0.000 0 0
Kidney development R-HSA-9830369 9.996234e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.996234e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.996546e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.996566e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996679e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.996990e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.996990e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.996990e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.996990e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.997715e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997724e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.997868e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997994e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.997994e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998044e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998233e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.998265e-01 0.000 0 0
G alpha (z) signalling events R-HSA-418597 9.998265e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998443e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.998683e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.998756e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.998869e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999000e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999000e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999033e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999062e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999062e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999062e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999063e-01 0.000 1 0
RAB geranylgeranylation R-HSA-8873719 9.999129e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999129e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999155e-01 0.000 1 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999155e-01 0.000 1 0
Platelet homeostasis R-HSA-418346 9.999233e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999241e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.999241e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999241e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999270e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999280e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.999280e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999360e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999469e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999498e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999498e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999606e-01 0.000 0 0
Regulation of insulin secretion R-HSA-422356 9.999606e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999764e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999784e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999809e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999809e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999809e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999851e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999909e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999936e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999936e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999944e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999957e-01 0.000 0 0
Disease R-HSA-1643685 9.999960e-01 0.000 1 0
Keratinization R-HSA-6805567 9.999969e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999973e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999976e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999980e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999984e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999988e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999989e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999991e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999992e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999995e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999998e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.423528e-12 11.847 0 0
Metabolism of RNA R-HSA-8953854 4.262772e-10 9.370 0 0
Cell Cycle, Mitotic R-HSA-69278 2.332427e-09 8.632 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.293397e-09 8.640 0 0
M Phase R-HSA-68886 1.351238e-08 7.869 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.277137e-08 7.643 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.596883e-08 7.586 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.596883e-08 7.586 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.715729e-08 7.326 0 0
Apoptotic execution phase R-HSA-75153 6.254521e-08 7.204 0 0
Cell Cycle Checkpoints R-HSA-69620 6.724210e-08 7.172 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.122071e-08 7.040 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.034184e-07 6.985 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.200820e-07 6.921 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.608769e-07 6.794 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.399773e-07 6.620 0 0
G2/M Checkpoints R-HSA-69481 3.065714e-07 6.513 0 0
Adherens junctions interactions R-HSA-418990 3.532158e-07 6.452 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.974303e-07 6.001 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.227118e-06 5.911 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.450618e-06 5.838 0 0
Cell junction organization R-HSA-446728 1.482874e-06 5.829 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.637255e-06 5.786 0 0
Cell-Cell communication R-HSA-1500931 1.596544e-06 5.797 0 0
DNA Double Strand Break Response R-HSA-5693606 1.863895e-06 5.730 0 0
Cell-cell junction organization R-HSA-421270 2.226091e-06 5.652 0 0
Mitotic Prometaphase R-HSA-68877 2.495088e-06 5.603 0 0
mRNA Splicing R-HSA-72172 2.555288e-06 5.593 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.836504e-06 5.547 0 0
Mitotic Prophase R-HSA-68875 3.073602e-06 5.512 0 0
Chromatin modifying enzymes R-HSA-3247509 5.144250e-06 5.289 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.665458e-06 5.247 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.921568e-06 5.228 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.095549e-06 5.215 0 0
Chromatin organization R-HSA-4839726 6.923270e-06 5.160 0 0
RNA Polymerase I Transcription R-HSA-73864 7.087820e-06 5.149 0 0
Nucleosome assembly R-HSA-774815 8.329475e-06 5.079 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.329475e-06 5.079 0 0
HDACs deacetylate histones R-HSA-3214815 9.957922e-06 5.002 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.189554e-05 4.925 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.201955e-05 4.920 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.317139e-05 4.880 0 0
Homology Directed Repair R-HSA-5693538 1.292512e-05 4.889 0 0
Regulation of TP53 Activity R-HSA-5633007 1.336824e-05 4.874 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.541902e-05 4.812 1 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.277609e-05 4.643 0 0
Signaling by ALK in cancer R-HSA-9700206 2.277609e-05 4.643 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.645537e-05 4.333 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.705023e-05 4.327 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.799437e-05 4.237 0 0
Meiotic synapsis R-HSA-1221632 5.799437e-05 4.237 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.373361e-05 4.132 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.922020e-05 4.101 0 0
DNA Repair R-HSA-73894 8.127944e-05 4.090 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.777838e-05 4.057 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.863226e-05 4.006 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.032780e-04 3.986 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.071420e-04 3.970 0 0
G2/M Transition R-HSA-69275 1.525723e-04 3.817 0 0
Apoptosis R-HSA-109581 1.492675e-04 3.826 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.628784e-04 3.788 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.568235e-04 3.805 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.568235e-04 3.805 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.675428e-04 3.776 0 0
Meiosis R-HSA-1500620 1.697931e-04 3.770 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.872924e-04 3.727 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.989083e-04 3.701 0 0
Translation initiation complex formation R-HSA-72649 2.040206e-04 3.690 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.445901e-04 3.612 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.770296e-04 3.557 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.986724e-04 3.525 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.004293e-04 3.522 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.142099e-04 3.503 0 0
G alpha (12/13) signalling events R-HSA-416482 3.239920e-04 3.489 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.458226e-04 3.461 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.521036e-04 3.453 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.457804e-04 3.461 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.858779e-04 3.414 0 0
Cilium Assembly R-HSA-5617833 4.249357e-04 3.372 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.343538e-04 3.362 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.766947e-04 3.322 0 0
Centrosome maturation R-HSA-380287 4.845593e-04 3.315 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.883323e-04 3.311 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.211029e-04 3.283 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.211029e-04 3.283 0 0
ESR-mediated signaling R-HSA-8939211 5.291920e-04 3.276 0 0
rRNA processing R-HSA-72312 6.046969e-04 3.218 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 6.418070e-04 3.193 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.649435e-04 3.177 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.510173e-04 3.124 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.519044e-04 3.124 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.805549e-04 3.108 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.818821e-04 3.055 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.818821e-04 3.055 0 0
Regulation of CDH1 Function R-HSA-9764561 9.333823e-04 3.030 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.001210e-03 2.999 0 0
Programmed Cell Death R-HSA-5357801 9.973283e-04 3.001 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.001210e-03 2.999 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.075208e-03 2.969 0 0
DNA methylation R-HSA-5334118 1.131256e-03 2.946 0 0
Protein ubiquitination R-HSA-8852135 1.134038e-03 2.945 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.227083e-03 2.911 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.256568e-03 2.901 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.371124e-03 2.863 0 0
Defective pyroptosis R-HSA-9710421 1.348344e-03 2.870 0 0
Signaling by Hippo R-HSA-2028269 1.410818e-03 2.851 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.435853e-03 2.843 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.435853e-03 2.843 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.570620e-03 2.804 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.759247e-03 2.755 0 0
Chromosome Maintenance R-HSA-73886 1.836147e-03 2.736 0 0
HATs acetylate histones R-HSA-3214847 1.767662e-03 2.753 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.728653e-03 2.762 0 0
Ribosome-associated quality control R-HSA-9948299 2.036486e-03 2.691 0 0
Meiotic recombination R-HSA-912446 2.134389e-03 2.671 0 0
Packaging Of Telomere Ends R-HSA-171306 2.211200e-03 2.655 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.217196e-03 2.654 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.287435e-03 2.641 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.403748e-03 2.619 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.623316e-03 2.581 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.623316e-03 2.581 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.727878e-03 2.564 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.727878e-03 2.564 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.041695e-03 2.517 0 0
Cellular Senescence R-HSA-2559583 3.111697e-03 2.507 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.200072e-03 2.495 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.281437e-03 2.484 0 0
Diseases of programmed cell death R-HSA-9645723 3.284009e-03 2.484 0 0
Striated Muscle Contraction R-HSA-390522 3.330180e-03 2.478 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.496924e-03 2.456 0 0
Separation of Sister Chromatids R-HSA-2467813 3.962803e-03 2.402 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.950410e-03 2.403 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.973058e-03 2.401 0 0
Mitotic Anaphase R-HSA-68882 3.984383e-03 2.400 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.279814e-03 2.369 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.515316e-03 2.345 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.515316e-03 2.345 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.541350e-03 2.343 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.593668e-03 2.338 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.728065e-03 2.325 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.728065e-03 2.325 0 0
Gene Silencing by RNA R-HSA-211000 4.754862e-03 2.323 0 0
Cellular responses to stimuli R-HSA-8953897 5.286857e-03 2.277 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.347225e-03 2.272 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.789870e-03 2.237 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.033054e-03 2.219 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.054039e-03 2.218 0 0
Cellular response to heat stress R-HSA-3371556 6.447727e-03 2.191 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.591246e-03 2.181 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.467119e-03 2.127 0 0
G-protein beta:gamma signalling R-HSA-397795 7.467119e-03 2.127 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.377327e-03 2.132 0 0
Cleavage of the damaged purine R-HSA-110331 6.894196e-03 2.162 0 0
Depyrimidination R-HSA-73928 7.377327e-03 2.132 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.377327e-03 2.132 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.746943e-03 2.111 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.746943e-03 2.111 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.885850e-03 2.103 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.961334e-03 2.099 0 0
Depurination R-HSA-73927 8.138781e-03 2.089 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.313014e-03 2.080 0 0
Signaling by WNT R-HSA-195721 8.489520e-03 2.071 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.701528e-03 2.060 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.875090e-03 2.052 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.899859e-03 2.051 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.108174e-03 2.041 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 9.552461e-03 2.020 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.008520e-02 1.996 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.013610e-02 1.994 0 0
Membrane Trafficking R-HSA-199991 9.710725e-03 2.013 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.972998e-03 2.001 0 0
Cellular responses to stress R-HSA-2262752 9.964057e-03 2.002 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.013610e-02 1.994 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.218316e-02 1.914 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.218316e-02 1.914 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.218316e-02 1.914 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.218316e-02 1.914 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.218316e-02 1.914 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.218316e-02 1.914 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.218316e-02 1.914 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.218316e-02 1.914 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.218316e-02 1.914 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.218316e-02 1.914 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.218316e-02 1.914 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.237839e-02 1.907 0 0
Peptide chain elongation R-HSA-156902 1.281754e-02 1.892 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.291607e-02 1.889 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.294514e-02 1.888 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.457993e-02 1.836 0 0
ALK mutants bind TKIs R-HSA-9700645 1.457993e-02 1.836 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.358437e-02 1.867 0 0
Gene expression (Transcription) R-HSA-74160 1.424624e-02 1.846 1 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.463764e-02 1.835 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.486709e-02 1.828 0 0
Recycling pathway of L1 R-HSA-437239 1.513977e-02 1.820 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.581942e-02 1.801 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.604965e-02 1.795 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.637484e-02 1.786 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.693617e-02 1.771 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.710226e-02 1.767 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.710226e-02 1.767 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.730744e-02 1.762 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.765765e-02 1.753 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.776554e-02 1.750 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.883395e-02 1.725 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.888280e-02 1.724 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.888280e-02 1.724 0 0
2-LTR circle formation R-HSA-164843 1.980720e-02 1.703 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.051764e-02 1.688 0 0
Influenza Infection R-HSA-168255 2.075489e-02 1.683 0 0
NRAGE signals death through JNK R-HSA-193648 2.166362e-02 1.664 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.166362e-02 1.664 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.184463e-02 1.661 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.197965e-02 1.658 0 0
DNA Replication R-HSA-69306 2.223458e-02 1.653 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.361074e-02 1.627 0 0
Nervous system development R-HSA-9675108 2.442994e-02 1.612 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.513065e-02 1.600 0 0
Axon guidance R-HSA-422475 2.557682e-02 1.592 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.613083e-02 1.583 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.634318e-02 1.579 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.634318e-02 1.579 0 0
mRNA 3'-end processing R-HSA-72187 2.797772e-02 1.553 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.878048e-02 1.541 0 0
G1/S Transition R-HSA-69206 2.878991e-02 1.541 0 0
Eukaryotic Translation Termination R-HSA-72764 2.905231e-02 1.537 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.925072e-02 1.534 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.925072e-02 1.534 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.995978e-02 1.523 0 0
snRNP Assembly R-HSA-191859 3.013740e-02 1.521 0 0
Metabolism of non-coding RNA R-HSA-194441 3.013740e-02 1.521 0 0
MTF1 activates gene expression R-HSA-5660489 3.467268e-02 1.460 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.467268e-02 1.460 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.361462e-02 1.473 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.361462e-02 1.473 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.257223e-02 1.487 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.342245e-02 1.476 0 0
PTEN Regulation R-HSA-6807070 3.314463e-02 1.480 0 0
Integration of provirus R-HSA-162592 3.361462e-02 1.473 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.342245e-02 1.476 0 0
Telomere Maintenance R-HSA-157579 3.416902e-02 1.466 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.467268e-02 1.460 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.560785e-02 1.448 0 0
Sensory processing of sound R-HSA-9659379 3.166819e-02 1.499 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.560785e-02 1.448 0 0
L1CAM interactions R-HSA-373760 3.788170e-02 1.422 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.807999e-02 1.419 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.807999e-02 1.419 0 0
G0 and Early G1 R-HSA-1538133 3.835280e-02 1.416 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.968566e-02 1.401 0 0
S Phase R-HSA-69242 3.990749e-02 1.399 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.056055e-02 1.392 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.080927e-02 1.389 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.116741e-02 1.385 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.230444e-02 1.374 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.271732e-02 1.369 0 0
Reproduction R-HSA-1474165 4.328226e-02 1.364 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.333578e-02 1.363 0 0
Interleukin-12 signaling R-HSA-9020591 4.375153e-02 1.359 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.386734e-02 1.358 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.387721e-02 1.358 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.387721e-02 1.358 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.415296e-02 1.355 0 0
HIV Life Cycle R-HSA-162587 4.456090e-02 1.351 0 0
Semaphorin interactions R-HSA-373755 4.489757e-02 1.348 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.922328e-02 1.308 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.060288e-02 1.296 0 0
HIV elongation arrest and recovery R-HSA-167287 5.051038e-02 1.297 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.051038e-02 1.297 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.522927e-02 1.258 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.338672e-02 1.273 0 0
Aggrephagy R-HSA-9646399 5.451674e-02 1.263 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.222793e-02 1.282 0 0
Unwinding of DNA R-HSA-176974 5.469821e-02 1.262 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.222793e-02 1.282 0 0
Neurexins and neuroligins R-HSA-6794361 5.510797e-02 1.259 0 0
Nuclear import of Rev protein R-HSA-180746 5.643037e-02 1.248 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.922328e-02 1.308 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.429451e-02 1.265 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.859467e-02 1.313 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.451674e-02 1.263 0 0
Signal Transduction R-HSA-162582 5.457701e-02 1.263 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.071010e-02 1.295 0 0
Deubiquitination R-HSA-5688426 5.557541e-02 1.255 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.062236e-02 1.296 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.667392e-02 1.247 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 5.667392e-02 1.247 0 0
Platelet sensitization by LDL R-HSA-432142 5.667392e-02 1.247 0 0
Presynaptic function of Kainate receptors R-HSA-500657 5.667392e-02 1.247 0 0
Death Receptor Signaling R-HSA-73887 5.670289e-02 1.246 0 0
IRE1alpha activates chaperones R-HSA-381070 5.719428e-02 1.243 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.736348e-02 1.241 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.775870e-02 1.238 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.804956e-02 1.236 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.804956e-02 1.236 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.804956e-02 1.236 0 0
Signaling by RAS mutants R-HSA-6802949 5.804956e-02 1.236 0 0
Diseases of DNA repair R-HSA-9675135 5.804956e-02 1.236 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.808080e-02 1.236 0 0
Macroautophagy R-HSA-1632852 5.825624e-02 1.235 0 0
PKR-mediated signaling R-HSA-9833482 6.080402e-02 1.216 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.089575e-02 1.215 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.089575e-02 1.215 0 0
Protein folding R-HSA-391251 6.152249e-02 1.211 0 0
Kinesins R-HSA-983189 6.268889e-02 1.203 0 0
Autophagy R-HSA-9612973 6.329019e-02 1.199 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.339481e-02 1.198 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.563270e-02 1.183 0 0
Activation of the pre-replicative complex R-HSA-68962 6.563270e-02 1.183 0 0
Amyloid fiber formation R-HSA-977225 6.568990e-02 1.183 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.600202e-02 1.180 0 0
Interleukin-12 family signaling R-HSA-447115 6.600202e-02 1.180 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.689072e-02 1.175 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.773954e-02 1.169 0 0
MAP2K and MAPK activation R-HSA-5674135 6.773954e-02 1.169 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.791577e-02 1.168 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.903037e-02 1.161 0 0
Phosphorylation of Emi1 R-HSA-176417 6.946267e-02 1.158 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.742849e-02 1.111 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.413899e-02 1.130 0 0
Trafficking of AMPA receptors R-HSA-399719 7.413899e-02 1.130 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.413899e-02 1.130 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.413899e-02 1.130 0 0
HSF1 activation R-HSA-3371511 7.111156e-02 1.148 0 0
Degradation of CDH1 R-HSA-9766229 7.784175e-02 1.109 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.965636e-02 1.157 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.037356e-02 1.095 0 0
Viral mRNA Translation R-HSA-192823 8.561540e-02 1.067 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.454310e-02 1.128 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.491539e-02 1.071 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.742849e-02 1.111 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.646093e-02 1.117 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.646093e-02 1.117 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.111156e-02 1.148 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.375754e-02 1.077 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.454310e-02 1.128 0 0
Selective autophagy R-HSA-9663891 7.095571e-02 1.149 0 0
HIV Infection R-HSA-162906 8.415810e-02 1.075 0 0
Glycolysis R-HSA-70171 7.053784e-02 1.152 0 0
Ub-specific processing proteases R-HSA-5689880 7.499260e-02 1.125 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.684636e-02 1.061 1 0
Cell-extracellular matrix interactions R-HSA-446353 7.579770e-02 1.120 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.579770e-02 1.120 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.042311e-02 1.152 0 0
Selenocysteine synthesis R-HSA-2408557 7.534839e-02 1.123 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.579770e-02 1.120 0 0
Signaling by ROBO receptors R-HSA-376176 7.571656e-02 1.121 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.728424e-02 1.059 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.774467e-02 1.057 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.784446e-02 1.056 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.848539e-02 1.053 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.921418e-02 1.050 0 0
Phosphorylation of the APC/C R-HSA-176412 8.941317e-02 1.049 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 9.100528e-02 1.041 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 9.305459e-02 1.031 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.305459e-02 1.031 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 9.305459e-02 1.031 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.305459e-02 1.031 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.305459e-02 1.031 0 0
HSF1-dependent transactivation R-HSA-3371571 9.313272e-02 1.031 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.494953e-02 1.023 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.675541e-02 1.014 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.675541e-02 1.014 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.719846e-02 1.012 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.787123e-02 1.009 0 0
Potential therapeutics for SARS R-HSA-9679191 9.934144e-02 1.003 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.014237e-01 0.994 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.108019e-01 0.955 0 0
Defective Base Excision Repair Associated with NEIL1 R-HSA-9616334 1.108019e-01 0.955 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.108019e-01 0.955 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.108019e-01 0.955 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.108019e-01 0.955 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.108019e-01 0.955 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.108019e-01 0.955 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.108019e-01 0.955 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.108019e-01 0.955 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.108019e-01 0.955 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.108019e-01 0.955 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.108019e-01 0.955 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.108019e-01 0.955 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.108019e-01 0.955 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.108019e-01 0.955 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.108019e-01 0.955 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.108019e-01 0.955 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.176700e-01 0.929 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.176700e-01 0.929 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 1.176700e-01 0.929 0 0
Regulation of PTEN localization R-HSA-8948747 1.149365e-01 0.940 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.149365e-01 0.940 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.025081e-01 0.989 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.216189e-01 0.915 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.216189e-01 0.915 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.216189e-01 0.915 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.216189e-01 0.915 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.216189e-01 0.915 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.216189e-01 0.915 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.216189e-01 0.915 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.216189e-01 0.915 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.042032e-01 0.982 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.042032e-01 0.982 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.201168e-01 0.920 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.201168e-01 0.920 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 1.299732e-01 0.886 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.222331e-01 0.913 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.144781e-01 0.941 0 0
HIV Transcription Elongation R-HSA-167169 1.069765e-01 0.971 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.069765e-01 0.971 0 0
Attenuation phase R-HSA-3371568 1.069765e-01 0.971 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.069765e-01 0.971 0 0
Transcription of the HIV genome R-HSA-167172 1.183070e-01 0.927 0 0
Neutrophil degranulation R-HSA-6798695 1.041986e-01 0.982 0 0
Nucleotide Excision Repair R-HSA-5696398 1.026556e-01 0.989 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.314301e-01 0.881 0 0
Signaling by ERBB2 R-HSA-1227986 1.104108e-01 0.957 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.034570e-01 0.985 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.266777e-01 0.897 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.042032e-01 0.982 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.020582e-01 0.991 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.019186e-01 0.992 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.216189e-01 0.915 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.341155e-01 0.873 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.069765e-01 0.971 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.288741e-01 0.890 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.116003e-01 0.952 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.270639e-01 0.896 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.019186e-01 0.992 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.018762e-01 0.992 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.144781e-01 0.941 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.176700e-01 0.929 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 1.149365e-01 0.940 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.096915e-01 0.960 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.144781e-01 0.941 0 0
Base Excision Repair R-HSA-73884 1.291000e-01 0.889 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.354728e-01 0.868 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.069765e-01 0.971 0 0
Smooth Muscle Contraction R-HSA-445355 1.101096e-01 0.958 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.336241e-01 0.874 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.155160e-01 0.937 1 1
RNA Polymerase II Transcription R-HSA-73857 1.021510e-01 0.991 1 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.299732e-01 0.886 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.034570e-01 0.985 0 0
Activation of BH3-only proteins R-HSA-114452 1.354728e-01 0.868 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.356228e-01 0.868 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.356228e-01 0.868 0 0
Polo-like kinase mediated events R-HSA-156711 1.370916e-01 0.863 0 0
G1/S-Specific Transcription R-HSA-69205 1.383207e-01 0.859 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.383351e-01 0.859 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.386790e-01 0.858 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.396450e-01 0.855 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.409356e-01 0.851 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.409356e-01 0.851 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.410232e-01 0.851 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.447775e-01 0.839 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.447775e-01 0.839 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.452501e-01 0.838 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.481385e-01 0.829 0 0
EGFR downregulation R-HSA-182971 1.493832e-01 0.826 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.493832e-01 0.826 0 0
Interferon Signaling R-HSA-913531 1.498941e-01 0.824 0 0
Inositol phosphate metabolism R-HSA-1483249 1.501056e-01 0.824 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.550556e-01 0.810 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.550556e-01 0.810 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.550556e-01 0.810 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 1.550556e-01 0.810 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.550556e-01 0.810 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.093324e-01 0.679 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.093324e-01 0.679 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.093324e-01 0.679 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.093324e-01 0.679 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.093324e-01 0.679 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.093324e-01 0.679 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.093324e-01 0.679 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.093324e-01 0.679 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.093324e-01 0.679 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.093324e-01 0.679 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.093324e-01 0.679 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.093324e-01 0.679 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.573826e-01 0.803 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.573826e-01 0.803 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.573826e-01 0.803 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.573826e-01 0.803 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.573826e-01 0.803 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.991304e-01 0.701 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.991304e-01 0.701 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.991304e-01 0.701 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.686712e-01 0.773 0 0
Gap junction degradation R-HSA-190873 1.686712e-01 0.773 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.978134e-01 0.704 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.978134e-01 0.704 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.978134e-01 0.704 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.978134e-01 0.704 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.978134e-01 0.704 0 0
DNA replication initiation R-HSA-68952 1.978134e-01 0.704 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.280426e-01 0.642 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.280426e-01 0.642 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.280426e-01 0.642 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.280426e-01 0.642 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.280426e-01 0.642 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.867266e-01 0.729 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 1.867266e-01 0.729 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.867266e-01 0.729 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.867266e-01 0.729 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.739292e-01 0.760 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.739292e-01 0.760 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.739292e-01 0.760 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.739292e-01 0.760 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.739292e-01 0.760 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.105278e-01 0.677 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.936264e-01 0.713 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.936264e-01 0.713 0 0
Disorders of Developmental Biology R-HSA-9675151 2.351205e-01 0.629 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.351205e-01 0.629 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.780734e-01 0.749 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.140570e-01 0.669 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.955127e-01 0.709 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.135591e-01 0.670 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.135591e-01 0.670 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.948015e-01 0.710 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.321508e-01 0.634 0 0
Orc1 removal from chromatin R-HSA-68949 1.738131e-01 0.760 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.738131e-01 0.760 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.896085e-01 0.722 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.860747e-01 0.730 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.860747e-01 0.730 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.860747e-01 0.730 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.860747e-01 0.730 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.117097e-01 0.674 0 0
Signaling by EGFR R-HSA-177929 2.250428e-01 0.648 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.328337e-01 0.633 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.822401e-01 0.739 0 0
Synthesis of DNA R-HSA-69239 1.701797e-01 0.769 0 0
G-protein activation R-HSA-202040 1.936264e-01 0.713 0 0
Regulation of CDH11 function R-HSA-9762292 1.978134e-01 0.704 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.638728e-01 0.785 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.867266e-01 0.729 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.926325e-01 0.715 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.123018e-01 0.673 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.686712e-01 0.773 0 0
TGFBR3 expression R-HSA-9839394 1.613007e-01 0.792 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 1.936264e-01 0.713 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.987134e-01 0.702 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.074377e-01 0.683 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.780734e-01 0.749 0 0
Signaling by NOTCH4 R-HSA-9013694 1.741510e-01 0.759 0 0
Translation R-HSA-72766 2.125387e-01 0.673 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.351205e-01 0.629 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.790848e-01 0.747 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.782369e-01 0.749 0 0
Stabilization of p53 R-HSA-69541 1.782888e-01 0.749 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.021087e-01 0.694 0 0
Negative regulation of MET activity R-HSA-6807004 1.739292e-01 0.760 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.717005e-01 0.765 0 0
Protein methylation R-HSA-8876725 1.867266e-01 0.729 0 0
Ca2+ pathway R-HSA-4086398 1.640494e-01 0.785 0 0
Signaling by NOTCH R-HSA-157118 1.807567e-01 0.743 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.334137e-01 0.632 0 0
Co-inhibition by PD-1 R-HSA-389948 2.220091e-01 0.654 0 0
Rab regulation of trafficking R-HSA-9007101 2.078093e-01 0.682 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.046401e-01 0.689 0 0
Inhibition of PKR R-HSA-169131 2.093324e-01 0.679 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 1.991304e-01 0.701 0 0
NrCAM interactions R-HSA-447038 1.991304e-01 0.701 0 0
Signaling by APC mutants R-HSA-4839744 2.280426e-01 0.642 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.316360e-01 0.635 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.316360e-01 0.635 0 0
Signaling by VEGF R-HSA-194138 1.568361e-01 0.805 0 0
HDMs demethylate histones R-HSA-3214842 1.613007e-01 0.792 0 0
Biotin transport and metabolism R-HSA-196780 1.867266e-01 0.729 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.061513e-01 0.686 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 2.280426e-01 0.642 1 1
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.686712e-01 0.773 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.955127e-01 0.709 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.790848e-01 0.747 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.644371e-01 0.784 0 0
Glucose metabolism R-HSA-70326 2.078093e-01 0.682 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.573826e-01 0.803 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 1.686712e-01 0.773 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.936264e-01 0.713 0 0
Basigin interactions R-HSA-210991 1.936264e-01 0.713 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.955127e-01 0.709 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.277592e-01 0.643 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.351205e-01 0.629 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.686712e-01 0.773 0 0
Glucagon-type ligand receptors R-HSA-420092 2.321508e-01 0.634 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.074377e-01 0.683 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.185866e-01 0.660 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.644371e-01 0.784 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.250428e-01 0.648 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.623348e-01 0.790 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.280426e-01 0.642 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.125649e-01 0.673 0 0
FGFR2 alternative splicing R-HSA-6803529 2.351278e-01 0.629 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.351278e-01 0.629 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.383002e-01 0.623 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.406457e-01 0.619 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.419754e-01 0.616 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.419754e-01 0.616 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.419754e-01 0.616 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.419754e-01 0.616 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.419754e-01 0.616 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.969501e-01 0.527 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.969501e-01 0.527 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.969501e-01 0.527 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.969501e-01 0.527 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.969501e-01 0.527 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.969501e-01 0.527 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.969501e-01 0.527 0 0
Signalling to ERK5 R-HSA-198765 3.748630e-01 0.426 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.748630e-01 0.426 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.748630e-01 0.426 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.748630e-01 0.426 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.851624e-01 0.545 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 2.851624e-01 0.545 0 0
Hydrolysis of LPE R-HSA-1483152 2.851624e-01 0.545 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.851624e-01 0.545 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.851624e-01 0.545 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 2.590560e-01 0.587 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.590560e-01 0.587 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.280899e-01 0.484 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.280899e-01 0.484 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.280899e-01 0.484 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.280899e-01 0.484 0 0
Recycling of eIF2:GDP R-HSA-72731 3.280899e-01 0.484 0 0
PLC-gamma1 signalling R-HSA-167021 4.441456e-01 0.352 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.441456e-01 0.352 0 0
Axonal growth stimulation R-HSA-209563 4.441456e-01 0.352 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 4.441456e-01 0.352 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.441456e-01 0.352 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 4.441456e-01 0.352 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.441456e-01 0.352 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.441456e-01 0.352 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.441456e-01 0.352 0 0
MET activates PTPN11 R-HSA-8865999 4.441456e-01 0.352 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.441456e-01 0.352 0 0
Invadopodia formation R-HSA-8941237 4.441456e-01 0.352 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 4.441456e-01 0.352 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.905716e-01 0.537 0 0
Disorders of Nervous System Development R-HSA-9697154 2.905716e-01 0.537 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.905716e-01 0.537 0 0
Pervasive developmental disorders R-HSA-9005895 2.905716e-01 0.537 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.603498e-01 0.584 0 0
Type I hemidesmosome assembly R-HSA-446107 3.702855e-01 0.431 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.702855e-01 0.431 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.702855e-01 0.431 0 0
Formation of annular gap junctions R-HSA-196025 3.702855e-01 0.431 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.223313e-01 0.492 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.567438e-01 0.591 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.567438e-01 0.591 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.567438e-01 0.591 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.512236e-01 0.600 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.788102e-01 0.555 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.788102e-01 0.555 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.121190e-01 0.506 0 0
Lipophagy R-HSA-9613354 4.113843e-01 0.386 0 0
Calcineurin activates NFAT R-HSA-2025928 4.113843e-01 0.386 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.012327e-01 0.521 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.012327e-01 0.521 0 0
G protein gated Potassium channels R-HSA-1296059 3.012327e-01 0.521 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.012327e-01 0.521 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.383741e-01 0.471 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.856762e-01 0.414 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.856762e-01 0.414 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.239192e-01 0.490 0 0
ERK/MAPK targets R-HSA-198753 3.646993e-01 0.438 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.646993e-01 0.438 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.511115e-01 0.346 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.511115e-01 0.346 0 0
Cristae formation R-HSA-8949613 3.467802e-01 0.460 0 0
Negative regulation of FLT3 R-HSA-9706369 4.168716e-01 0.380 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 4.168716e-01 0.380 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.168716e-01 0.380 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.040328e-01 0.517 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.040328e-01 0.517 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.909730e-01 0.408 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.909730e-01 0.408 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.909730e-01 0.408 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.697299e-01 0.432 0 0
RAF activation R-HSA-5673000 3.515205e-01 0.454 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.210824e-01 0.493 0 0
Intraflagellar transport R-HSA-5620924 3.383024e-01 0.471 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.721156e-01 0.429 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.926863e-01 0.406 0 0
Late endosomal microautophagy R-HSA-9615710 3.926863e-01 0.406 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.170832e-01 0.380 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.170832e-01 0.380 0 0
PECAM1 interactions R-HSA-210990 4.892663e-01 0.310 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.927456e-01 0.406 0 0
Dual incision in TC-NER R-HSA-6782135 3.725975e-01 0.429 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.775193e-01 0.321 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.775193e-01 0.321 0 0
HCMV Early Events R-HSA-9609690 2.512835e-01 0.600 0 0
Deadenylation of mRNA R-HSA-429947 4.684154e-01 0.329 0 0
Post-translational protein phosphorylation R-HSA-8957275 4.049078e-01 0.393 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.831108e-01 0.316 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.745132e-01 0.324 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.777983e-01 0.321 0 0
RNA Polymerase III Transcription R-HSA-74158 3.927456e-01 0.406 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.831108e-01 0.316 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.168854e-01 0.499 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.168854e-01 0.499 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.512236e-01 0.600 0 0
mRNA Capping R-HSA-72086 3.926863e-01 0.406 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.155722e-01 0.381 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.741713e-01 0.562 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.945525e-01 0.531 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.945525e-01 0.531 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.945525e-01 0.531 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.590560e-01 0.587 0 0
DNA strand elongation R-HSA-69190 2.905518e-01 0.537 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.475308e-01 0.349 0 0
Repression of WNT target genes R-HSA-4641265 2.905716e-01 0.537 0 0
Frs2-mediated activation R-HSA-170968 3.223313e-01 0.492 0 0
Hydrolysis of LPC R-HSA-1483115 3.541020e-01 0.451 0 0
FLT3 signaling in disease R-HSA-9682385 3.927456e-01 0.406 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.905518e-01 0.537 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.775193e-01 0.321 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.629790e-01 0.580 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.467802e-01 0.460 0 0
Generation of second messenger molecules R-HSA-202433 4.745132e-01 0.324 0 0
Signaling by FGFR2 R-HSA-5654738 3.415583e-01 0.467 0 0
Signaling by FGFR4 R-HSA-5654743 3.919288e-01 0.407 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.860646e-01 0.544 0 0
Thromboxane signalling through TP receptor R-HSA-428930 2.788102e-01 0.555 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.511115e-01 0.346 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.475308e-01 0.349 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.414981e-01 0.467 0 0
Nuclear RNA decay R-HSA-9930044 3.106759e-01 0.508 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.821366e-01 0.550 0 0
Signaling by FGFR3 R-HSA-5654741 4.296660e-01 0.367 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.467802e-01 0.460 0 0
Long-term potentiation R-HSA-9620244 4.934637e-01 0.307 0 0
Mitochondrial protein import R-HSA-1268020 4.382267e-01 0.358 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.831108e-01 0.316 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.271111e-01 0.485 0 0
Prolonged ERK activation events R-HSA-169893 4.168716e-01 0.380 0 0
Signal amplification R-HSA-392518 3.515205e-01 0.454 0 0
Signaling by Erythropoietin R-HSA-9006335 3.926863e-01 0.406 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.590560e-01 0.587 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.223313e-01 0.492 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.541020e-01 0.451 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.383741e-01 0.471 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.856762e-01 0.414 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.239192e-01 0.490 0 0
Formation of the posterior neural plate R-HSA-9832991 4.892663e-01 0.310 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.155722e-01 0.381 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.393264e-01 0.357 0 0
LDL clearance R-HSA-8964038 4.170832e-01 0.380 0 0
Ion homeostasis R-HSA-5578775 4.777983e-01 0.321 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.113843e-01 0.386 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.856762e-01 0.414 0 0
Signaling by WNT in cancer R-HSA-4791275 4.608488e-01 0.336 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.630296e-01 0.440 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.168716e-01 0.380 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.889832e-01 0.410 0 0
Vesicle-mediated transport R-HSA-5653656 3.283763e-01 0.484 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.046837e-01 0.516 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.630296e-01 0.440 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.133533e-01 0.384 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.926863e-01 0.406 0 0
TCR signaling R-HSA-202403 3.630296e-01 0.440 0 0
Platelet homeostasis R-HSA-418346 4.143459e-01 0.383 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.906621e-01 0.309 0 0
RMTs methylate histone arginines R-HSA-3214858 2.705973e-01 0.568 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.385064e-01 0.470 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.414981e-01 0.467 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.748630e-01 0.426 0 0
Antagonism of Activin by Follistatin R-HSA-2473224 3.748630e-01 0.426 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.748630e-01 0.426 0 0
CREB phosphorylation R-HSA-199920 2.851624e-01 0.545 0 0
Signaling by AXIN mutants R-HSA-4839735 2.590560e-01 0.587 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.590560e-01 0.587 0 0
MET interacts with TNS proteins R-HSA-8875513 4.441456e-01 0.352 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.702855e-01 0.431 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.702855e-01 0.431 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.223313e-01 0.492 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.860646e-01 0.544 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.860646e-01 0.544 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.871917e-01 0.542 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.909730e-01 0.408 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.959646e-01 0.529 0 0
DARPP-32 events R-HSA-180024 3.926863e-01 0.406 0 0
Bicarbonate transporters R-HSA-425381 4.892663e-01 0.310 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.775193e-01 0.321 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.383154e-01 0.358 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.542870e-01 0.343 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.904635e-01 0.309 0 0
Co-stimulation by CD28 R-HSA-389356 3.383024e-01 0.471 0 0
Muscle contraction R-HSA-397014 3.225605e-01 0.491 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.168716e-01 0.380 0 0
MAP kinase activation R-HSA-450294 4.218263e-01 0.375 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.871917e-01 0.542 0 0
EPH-Ephrin signaling R-HSA-2682334 4.215122e-01 0.375 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.437559e-01 0.353 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.542148e-01 0.451 0 0
UCH proteinases R-HSA-5689603 2.875600e-01 0.541 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.725975e-01 0.429 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.989321e-01 0.399 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.871917e-01 0.542 0 0
NGF-stimulated transcription R-HSA-9031628 3.383024e-01 0.471 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.658794e-01 0.575 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.860646e-01 0.544 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.113843e-01 0.386 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.511115e-01 0.346 0 0
tRNA processing in the nucleus R-HSA-6784531 3.108303e-01 0.507 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.239407e-01 0.490 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.608488e-01 0.336 0 0
MTOR signalling R-HSA-165159 3.730468e-01 0.428 0 0
Opioid Signalling R-HSA-111885 2.821366e-01 0.550 0 0
CHL1 interactions R-HSA-447041 3.280899e-01 0.484 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.113843e-01 0.386 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.170832e-01 0.380 0 0
LGI-ADAM interactions R-HSA-5682910 4.892663e-01 0.310 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.984833e-01 0.525 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.545764e-01 0.342 0 0
Host Interactions of HIV factors R-HSA-162909 2.742668e-01 0.562 0 0
Integration of energy metabolism R-HSA-163685 4.346532e-01 0.362 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.354786e-01 0.474 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 2.603498e-01 0.584 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.860646e-01 0.544 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.851624e-01 0.545 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.113843e-01 0.386 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.310199e-01 0.480 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.475308e-01 0.349 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.608488e-01 0.336 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.745132e-01 0.324 0 0
Circadian clock R-HSA-9909396 4.726692e-01 0.325 0 0
Nephrin family interactions R-HSA-373753 3.383741e-01 0.471 0 0
Signaling by TGFBR3 R-HSA-9839373 4.484375e-01 0.348 0 0
PI Metabolism R-HSA-1483255 3.523996e-01 0.453 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.133533e-01 0.384 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.775193e-01 0.321 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 4.542870e-01 0.343 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.542870e-01 0.343 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.788102e-01 0.555 0 0
Neurodegenerative Diseases R-HSA-8863678 2.788102e-01 0.555 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.542148e-01 0.451 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.748630e-01 0.426 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.280899e-01 0.484 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.280899e-01 0.484 0 0
Sodium/Proton exchangers R-HSA-425986 3.702855e-01 0.431 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.511115e-01 0.346 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.271500e-01 0.369 0 0
Viral Infection Pathways R-HSA-9824446 4.351118e-01 0.361 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.280899e-01 0.484 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.280899e-01 0.484 0 0
Expression and Processing of Neurotrophins R-HSA-9036866 4.441456e-01 0.352 0 0
NGF processing R-HSA-167060 4.441456e-01 0.352 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.702855e-01 0.431 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.113843e-01 0.386 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.040328e-01 0.517 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.441041e-01 0.353 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.860646e-01 0.544 0 0
SARS-CoV Infections R-HSA-9679506 3.111408e-01 0.507 0 0
Response to metal ions R-HSA-5660526 4.475308e-01 0.349 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.799586e-01 0.319 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.542870e-01 0.343 0 0
Synthesis and processing of ENV and VPU R-HSA-171286 3.748630e-01 0.426 0 0
FLT3 Signaling R-HSA-9607240 4.945179e-01 0.306 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.945179e-01 0.306 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.945179e-01 0.306 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.945179e-01 0.306 0 0
Platelet degranulation R-HSA-114608 5.010192e-01 0.300 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.018722e-01 0.299 0 0
Gap junction trafficking and regulation R-HSA-157858 5.039028e-01 0.298 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.050451e-01 0.297 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.050451e-01 0.297 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.050451e-01 0.297 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.057533e-01 0.296 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.057533e-01 0.296 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.057533e-01 0.296 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.057533e-01 0.296 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.057533e-01 0.296 0 0
Regulation of gap junction activity R-HSA-191650 5.057533e-01 0.296 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.057533e-01 0.296 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.057533e-01 0.296 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.057533e-01 0.296 0 0
NADE modulates death signalling R-HSA-205025 5.057533e-01 0.296 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.057533e-01 0.296 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.067248e-01 0.295 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.067248e-01 0.295 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.102685e-01 0.292 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.125330e-01 0.290 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.142597e-01 0.289 0 0
HIV Transcription Initiation R-HSA-167161 5.142597e-01 0.289 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.142597e-01 0.289 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.142597e-01 0.289 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.142597e-01 0.289 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.142597e-01 0.289 0 0
Regulation of insulin secretion R-HSA-422356 5.150550e-01 0.288 0 0
Myogenesis R-HSA-525793 5.180010e-01 0.286 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.180010e-01 0.286 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.180010e-01 0.286 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.180010e-01 0.286 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.180010e-01 0.286 0 0
ERKs are inactivated R-HSA-202670 5.257094e-01 0.279 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.257094e-01 0.279 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.257094e-01 0.279 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.257094e-01 0.279 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.257094e-01 0.279 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.266011e-01 0.279 0 0
Dual Incision in GG-NER R-HSA-5696400 5.266011e-01 0.279 0 0
Mitophagy R-HSA-5205647 5.266011e-01 0.279 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.266011e-01 0.279 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.266011e-01 0.279 0 0
MAPK family signaling cascades R-HSA-5683057 5.269554e-01 0.278 0 0
Generic Transcription Pathway R-HSA-212436 5.335381e-01 0.273 1 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.337005e-01 0.273 0 0
The NLRP3 inflammasome R-HSA-844456 5.350553e-01 0.272 0 0
Maturation of nucleoprotein R-HSA-9694631 5.350553e-01 0.272 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.379635e-01 0.269 0 0
Hedgehog 'off' state R-HSA-5610787 5.411196e-01 0.267 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.419650e-01 0.266 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.419650e-01 0.266 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.477335e-01 0.261 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.477335e-01 0.261 0 0
Regulation of Apoptosis R-HSA-169911 5.477335e-01 0.261 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.528057e-01 0.257 0 0
TBC/RABGAPs R-HSA-8854214 5.528057e-01 0.257 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.528057e-01 0.257 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.547717e-01 0.256 0 0
Leading Strand Synthesis R-HSA-69109 5.603516e-01 0.252 0 0
Polymerase switching R-HSA-69091 5.603516e-01 0.252 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.603516e-01 0.252 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.603516e-01 0.252 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.603516e-01 0.252 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.603516e-01 0.252 0 0
OAS antiviral response R-HSA-8983711 5.603516e-01 0.252 0 0
Co-inhibition by BTLA R-HSA-9927353 5.605360e-01 0.251 0 0
G2 Phase R-HSA-68911 5.605360e-01 0.251 0 0
Defective F9 activation R-HSA-9673221 5.605360e-01 0.251 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.605360e-01 0.251 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.605360e-01 0.251 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.605360e-01 0.251 0 0
Activation of AKT2 R-HSA-165158 5.605360e-01 0.251 0 0
Reelin signalling pathway R-HSA-8866376 5.605360e-01 0.251 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.605360e-01 0.251 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.605360e-01 0.251 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.605360e-01 0.251 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.605360e-01 0.251 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.605360e-01 0.251 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.605360e-01 0.251 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.605360e-01 0.251 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.605360e-01 0.251 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.605360e-01 0.251 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.605360e-01 0.251 0 0
Aquaporin-mediated transport R-HSA-445717 5.616170e-01 0.251 0 0
Selenoamino acid metabolism R-HSA-2408522 5.616744e-01 0.251 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.624373e-01 0.250 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 5.624373e-01 0.250 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.624373e-01 0.250 0 0
Signal transduction by L1 R-HSA-445144 5.624373e-01 0.250 0 0
Protein hydroxylation R-HSA-9629569 5.624373e-01 0.250 0 0
Formation of definitive endoderm R-HSA-9823730 5.624373e-01 0.250 0 0
Telomere Extension By Telomerase R-HSA-171319 5.653023e-01 0.248 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.653023e-01 0.248 0 0
Interleukin-17 signaling R-HSA-448424 5.655534e-01 0.248 0 0
RET signaling R-HSA-8853659 5.684024e-01 0.245 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.684024e-01 0.245 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.715441e-01 0.243 0 0
Proteasome assembly R-HSA-9907900 5.715441e-01 0.243 0 0
Gap junction trafficking R-HSA-190828 5.715441e-01 0.243 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.715441e-01 0.243 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.755137e-01 0.240 0 0
Signaling by NTRKs R-HSA-166520 5.755137e-01 0.240 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.799923e-01 0.237 0 0
Signaling by MET R-HSA-6806834 5.835372e-01 0.234 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.852954e-01 0.233 0 0
Platelet calcium homeostasis R-HSA-418360 5.879686e-01 0.231 0 0
Degradation of DVL R-HSA-4641258 5.885732e-01 0.230 0 0
Degradation of AXIN R-HSA-4641257 5.885732e-01 0.230 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.885732e-01 0.230 0 0
Cellular response to starvation R-HSA-9711097 5.886803e-01 0.230 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.888143e-01 0.230 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.898881e-01 0.229 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.898881e-01 0.229 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.898881e-01 0.229 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.898881e-01 0.229 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.898881e-01 0.229 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.898881e-01 0.229 0 0
DAG and IP3 signaling R-HSA-1489509 5.898881e-01 0.229 0 0
Somitogenesis R-HSA-9824272 5.898881e-01 0.229 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.898881e-01 0.229 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.898881e-01 0.229 0 0
Maturation of nucleoprotein R-HSA-9683610 5.931442e-01 0.227 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.931442e-01 0.227 0 0
Signaling by PTK6 R-HSA-8848021 5.934888e-01 0.227 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.934888e-01 0.227 0 0
ER-Phagosome pathway R-HSA-1236974 5.997258e-01 0.222 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.061035e-01 0.217 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.063674e-01 0.217 0 0
Signaling by NOTCH3 R-HSA-9012852 6.081678e-01 0.216 0 0
MET promotes cell motility R-HSA-8875878 6.082160e-01 0.216 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.082160e-01 0.216 0 0
Signaling by TGFB family members R-HSA-9006936 6.085570e-01 0.216 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.092494e-01 0.215 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.092494e-01 0.215 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.092494e-01 0.215 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.092494e-01 0.215 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.092494e-01 0.215 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.092494e-01 0.215 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.092494e-01 0.215 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.092494e-01 0.215 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.092494e-01 0.215 0 0
PDE3B signalling R-HSA-165160 6.092494e-01 0.215 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.092494e-01 0.215 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 6.092494e-01 0.215 0 0
PKB-mediated events R-HSA-109703 6.092494e-01 0.215 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.092494e-01 0.215 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.092494e-01 0.215 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.092494e-01 0.215 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.092494e-01 0.215 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.092494e-01 0.215 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.092494e-01 0.215 0 0
Diseases of Base Excision Repair R-HSA-9605308 6.092494e-01 0.215 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.092494e-01 0.215 0 0
DAP12 signaling R-HSA-2424491 6.099275e-01 0.215 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.099275e-01 0.215 0 0
Interleukin-37 signaling R-HSA-9008059 6.099275e-01 0.215 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.141447e-01 0.212 0 0
Removal of the Flap Intermediate R-HSA-69166 6.240718e-01 0.205 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.240718e-01 0.205 0 0
Regulation of KIT signaling R-HSA-1433559 6.240718e-01 0.205 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.240718e-01 0.205 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.240718e-01 0.205 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.240718e-01 0.205 0 0
Signal regulatory protein family interactions R-HSA-391160 6.240718e-01 0.205 0 0
Signaling by FGFR1 R-HSA-5654736 6.243887e-01 0.205 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.243887e-01 0.205 0 0
Signaling by FGFR in disease R-HSA-1226099 6.244479e-01 0.205 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.252984e-01 0.204 0 0
Signaling by FGFR R-HSA-190236 6.268753e-01 0.203 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.268753e-01 0.203 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.268753e-01 0.203 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.268753e-01 0.203 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.292276e-01 0.201 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.311503e-01 0.200 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.318700e-01 0.199 0 0
Notch-HLH transcription pathway R-HSA-350054 6.384008e-01 0.195 0 0
mTORC1-mediated signalling R-HSA-166208 6.384008e-01 0.195 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.384008e-01 0.195 0 0
MHC class II antigen presentation R-HSA-2132295 6.414449e-01 0.193 0 0
GPER1 signaling R-HSA-9634597 6.423256e-01 0.192 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.512754e-01 0.186 0 0
VLDL assembly R-HSA-8866423 6.525656e-01 0.185 0 0
Chylomicron clearance R-HSA-8964026 6.525656e-01 0.185 0 0
Signaling by LTK in cancer R-HSA-9842640 6.525656e-01 0.185 0 0
STAT5 Activation R-HSA-9645135 6.525656e-01 0.185 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.525656e-01 0.185 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.525656e-01 0.185 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.525656e-01 0.185 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.525656e-01 0.185 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.525656e-01 0.185 0 0
Neurofascin interactions R-HSA-447043 6.525656e-01 0.185 0 0
Lactose synthesis R-HSA-5653890 6.525656e-01 0.185 0 0
NADPH regeneration R-HSA-389542 6.525656e-01 0.185 0 0
Nef and signal transduction R-HSA-164944 6.525656e-01 0.185 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.525656e-01 0.185 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.531448e-01 0.185 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.531448e-01 0.185 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.531448e-01 0.185 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.531448e-01 0.185 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.531448e-01 0.185 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.531448e-01 0.185 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.531448e-01 0.185 0 0
p75NTR signals via NF-kB R-HSA-193639 6.531448e-01 0.185 0 0
Other semaphorin interactions R-HSA-416700 6.531448e-01 0.185 0 0
Formation of the anterior neural plate R-HSA-9823739 6.531448e-01 0.185 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.531448e-01 0.185 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.531448e-01 0.185 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.531448e-01 0.185 0 0
Toll-like Receptor Cascades R-HSA-168898 6.594319e-01 0.181 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.626140e-01 0.179 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.637502e-01 0.178 0 0
Extension of Telomeres R-HSA-180786 6.707193e-01 0.173 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.713076e-01 0.173 0 0
Integrin signaling R-HSA-354192 6.713076e-01 0.173 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.713076e-01 0.173 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.749487e-01 0.171 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.771784e-01 0.169 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.803943e-01 0.167 0 0
Activation of SMO R-HSA-5635838 6.803943e-01 0.167 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.803943e-01 0.167 0 0
Intra-Golgi traffic R-HSA-6811438 6.810761e-01 0.167 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.810761e-01 0.167 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.810761e-01 0.167 0 0
Interferon gamma signaling R-HSA-877300 6.832268e-01 0.165 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.836361e-01 0.165 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.836361e-01 0.165 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.836361e-01 0.165 0 0
Post NMDA receptor activation events R-HSA-438064 6.891117e-01 0.162 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.905230e-01 0.161 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.905230e-01 0.161 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 6.910822e-01 0.160 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.910822e-01 0.160 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.910822e-01 0.160 0 0
VLDL clearance R-HSA-8964046 6.910822e-01 0.160 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 6.910822e-01 0.160 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.910822e-01 0.160 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.910822e-01 0.160 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.910822e-01 0.160 0 0
PTK6 Expression R-HSA-8849473 6.910822e-01 0.160 0 0
LDL remodeling R-HSA-8964041 6.910822e-01 0.160 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.910822e-01 0.160 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.910822e-01 0.160 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.910822e-01 0.160 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.910822e-01 0.160 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.910822e-01 0.160 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.910822e-01 0.160 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.942794e-01 0.158 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.942794e-01 0.158 0 0
COPII-mediated vesicle transport R-HSA-204005 6.950594e-01 0.158 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.950594e-01 0.158 0 0
Activation of GABAB receptors R-HSA-991365 6.977922e-01 0.156 0 0
Ca-dependent events R-HSA-111996 6.977922e-01 0.156 0 0
GABA B receptor activation R-HSA-977444 6.977922e-01 0.156 0 0
PLC beta mediated events R-HSA-112043 6.995539e-01 0.155 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.995539e-01 0.155 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.046131e-01 0.152 0 0
Tight junction interactions R-HSA-420029 7.046131e-01 0.152 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.046131e-01 0.152 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.046131e-01 0.152 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.046131e-01 0.152 0 0
Interleukin-7 signaling R-HSA-1266695 7.046131e-01 0.152 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.055958e-01 0.151 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.055958e-01 0.151 1 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.058672e-01 0.151 0 0
Glycine degradation R-HSA-6783984 7.058672e-01 0.151 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.058672e-01 0.151 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.058672e-01 0.151 0 0
Hedgehog 'on' state R-HSA-5632684 7.081570e-01 0.150 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.083417e-01 0.150 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.099254e-01 0.149 0 0
HCMV Infection R-HSA-9609646 7.104604e-01 0.148 0 0
Heme signaling R-HSA-9707616 7.133331e-01 0.147 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.163489e-01 0.145 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.193934e-01 0.143 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.209010e-01 0.142 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.241283e-01 0.140 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.241283e-01 0.140 0 0
TRP channels R-HSA-3295583 7.245085e-01 0.140 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.245085e-01 0.140 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.253309e-01 0.139 0 0
RSK activation R-HSA-444257 7.253309e-01 0.139 0 0
phospho-PLA2 pathway R-HSA-111995 7.253309e-01 0.139 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.253309e-01 0.139 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.253309e-01 0.139 0 0
MET receptor recycling R-HSA-8875656 7.253309e-01 0.139 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.253309e-01 0.139 0 0
Adrenoceptors R-HSA-390696 7.253309e-01 0.139 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.253309e-01 0.139 0 0
Regulation by c-FLIP R-HSA-3371378 7.253309e-01 0.139 0 0
Co-stimulation by ICOS R-HSA-9927354 7.253309e-01 0.139 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.253309e-01 0.139 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.253309e-01 0.139 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.253309e-01 0.139 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.253309e-01 0.139 0 0
Dimerization of procaspase-8 R-HSA-69416 7.253309e-01 0.139 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.253309e-01 0.139 0 0
Nucleotide salvage defects R-HSA-9734207 7.253309e-01 0.139 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.253309e-01 0.139 0 0
Signalling to ERKs R-HSA-187687 7.256803e-01 0.139 0 0
Cyclin D associated events in G1 R-HSA-69231 7.293779e-01 0.137 0 0
G1 Phase R-HSA-69236 7.293779e-01 0.137 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.296225e-01 0.137 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.296225e-01 0.137 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.296225e-01 0.137 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.296225e-01 0.137 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.296225e-01 0.137 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.318865e-01 0.136 0 0
Adipogenesis R-HSA-9843745 7.408023e-01 0.130 0 0
FOXO-mediated transcription R-HSA-9614085 7.420386e-01 0.130 0 0
GPVI-mediated activation cascade R-HSA-114604 7.422386e-01 0.129 0 0
Calmodulin induced events R-HSA-111933 7.422386e-01 0.129 0 0
CaM pathway R-HSA-111997 7.422386e-01 0.129 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.433401e-01 0.129 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.433401e-01 0.129 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.433401e-01 0.129 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.433401e-01 0.129 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.433401e-01 0.129 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.442468e-01 0.128 0 0
HCMV Late Events R-HSA-9610379 7.443715e-01 0.128 0 0
Signaling by ERBB4 R-HSA-1236394 7.451996e-01 0.128 0 0
G alpha (z) signalling events R-HSA-418597 7.477700e-01 0.126 0 0
GAB1 signalosome R-HSA-180292 7.517279e-01 0.124 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.517279e-01 0.124 0 0
Mismatch Repair R-HSA-5358508 7.517279e-01 0.124 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.517279e-01 0.124 0 0
Apoptotic factor-mediated response R-HSA-111471 7.517279e-01 0.124 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.517279e-01 0.124 0 0
Nephron development R-HSA-9831926 7.517279e-01 0.124 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.517279e-01 0.124 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.557844e-01 0.122 0 0
CASP8 activity is inhibited R-HSA-5218900 7.557844e-01 0.122 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.557844e-01 0.122 0 0
ARMS-mediated activation R-HSA-170984 7.557844e-01 0.122 0 0
WNT mediated activation of DVL R-HSA-201688 7.557844e-01 0.122 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.557844e-01 0.122 0 0
Interleukin-1 processing R-HSA-448706 7.557844e-01 0.122 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.557844e-01 0.122 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.585038e-01 0.120 0 0
TNF signaling R-HSA-75893 7.608123e-01 0.119 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.611307e-01 0.119 0 0
Inflammasomes R-HSA-622312 7.611307e-01 0.119 0 0
Interleukin-1 signaling R-HSA-9020702 7.620800e-01 0.118 0 0
Mitochondrial biogenesis R-HSA-1592230 7.639976e-01 0.117 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.721548e-01 0.112 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.721548e-01 0.112 0 0
Synthesis of PC R-HSA-1483191 7.721548e-01 0.112 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.722025e-01 0.112 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.722571e-01 0.112 0 0
Regulation of signaling by CBL R-HSA-912631 7.722571e-01 0.112 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.722571e-01 0.112 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.722571e-01 0.112 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.722571e-01 0.112 0 0
Specification of the neural plate border R-HSA-9834899 7.722571e-01 0.112 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.722571e-01 0.112 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.722571e-01 0.112 0 0
Translesion Synthesis by POLH R-HSA-110320 7.722571e-01 0.112 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.724652e-01 0.112 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.730526e-01 0.112 0 0
G-protein mediated events R-HSA-112040 7.757404e-01 0.110 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.779078e-01 0.109 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.779078e-01 0.109 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.828629e-01 0.106 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.828629e-01 0.106 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.828629e-01 0.106 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.828629e-01 0.106 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.828629e-01 0.106 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.828629e-01 0.106 0 0
Pexophagy R-HSA-9664873 7.828629e-01 0.106 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.828629e-01 0.106 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.828629e-01 0.106 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.828629e-01 0.106 0 0
Josephin domain DUBs R-HSA-5689877 7.828629e-01 0.106 0 0
Interleukin-27 signaling R-HSA-9020956 7.828629e-01 0.106 0 0
Maturation of spike protein R-HSA-9683686 7.828629e-01 0.106 0 0
Gluconeogenesis R-HSA-70263 7.852080e-01 0.105 0 0
Metal ion SLC transporters R-HSA-425410 7.852080e-01 0.105 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.861486e-01 0.104 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.873350e-01 0.104 0 0
Signaling by ALK R-HSA-201556 7.873350e-01 0.104 0 0
PCP/CE pathway R-HSA-4086400 7.893000e-01 0.103 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.912879e-01 0.102 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.912879e-01 0.102 0 0
Acyl chain remodelling of PI R-HSA-1482922 7.912879e-01 0.102 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.937025e-01 0.100 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.937025e-01 0.100 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.937025e-01 0.100 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.976731e-01 0.098 0 0
DNA Damage Bypass R-HSA-73893 7.976731e-01 0.098 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.986615e-01 0.098 0 0
Diseases of Immune System R-HSA-5260271 8.008898e-01 0.096 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.008898e-01 0.096 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.008898e-01 0.096 0 0
Signaling by Hedgehog R-HSA-5358351 8.061169e-01 0.094 0 0
Chylomicron assembly R-HSA-8963888 8.069404e-01 0.093 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.069404e-01 0.093 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.069404e-01 0.093 0 0
vRNP Assembly R-HSA-192905 8.069404e-01 0.093 0 0
vRNA Synthesis R-HSA-192814 8.069404e-01 0.093 0 0
Synthesis of PI R-HSA-1483226 8.069404e-01 0.093 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.069404e-01 0.093 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.069404e-01 0.093 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.069404e-01 0.093 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.069404e-01 0.093 0 0
Suppression of apoptosis R-HSA-9635465 8.069404e-01 0.093 0 0
Interleukin-2 signaling R-HSA-9020558 8.069404e-01 0.093 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.069404e-01 0.093 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.079993e-01 0.093 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.079993e-01 0.093 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.079993e-01 0.093 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.079993e-01 0.093 0 0
GABA receptor activation R-HSA-977443 8.079993e-01 0.093 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.079993e-01 0.093 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.089000e-01 0.092 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.089000e-01 0.092 0 0
Lagging Strand Synthesis R-HSA-69186 8.089000e-01 0.092 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.089000e-01 0.092 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.089000e-01 0.092 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.089000e-01 0.092 0 0
PI3K Cascade R-HSA-109704 8.095617e-01 0.092 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.095617e-01 0.092 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.137706e-01 0.089 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.185849e-01 0.087 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.189568e-01 0.087 0 0
Downstream TCR signaling R-HSA-202424 8.197144e-01 0.086 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.208867e-01 0.086 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.224821e-01 0.085 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.251740e-01 0.083 0 0
Attachment and Entry R-HSA-9694614 8.251740e-01 0.083 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.251740e-01 0.083 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.258946e-01 0.083 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.283493e-01 0.082 0 0
DS-GAG biosynthesis R-HSA-2022923 8.283493e-01 0.082 0 0
Scavenging by Class H Receptors R-HSA-3000497 8.283493e-01 0.082 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.283493e-01 0.082 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.283493e-01 0.082 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.283493e-01 0.082 0 0
NF-kB is activated and signals survival R-HSA-209560 8.283493e-01 0.082 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.283493e-01 0.082 0 0
Activation of RAC1 R-HSA-428540 8.283493e-01 0.082 0 0
Sodium/Calcium exchangers R-HSA-425561 8.283493e-01 0.082 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.283493e-01 0.082 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.313100e-01 0.080 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.316621e-01 0.080 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.373875e-01 0.077 0 0
ABC-family proteins mediated transport R-HSA-382556 8.373922e-01 0.077 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.401901e-01 0.076 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.401901e-01 0.076 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.401901e-01 0.076 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.444346e-01 0.073 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.473853e-01 0.072 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.473853e-01 0.072 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.473853e-01 0.072 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.473853e-01 0.072 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.473853e-01 0.072 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.473853e-01 0.072 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.473853e-01 0.072 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.473853e-01 0.072 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 8.473853e-01 0.072 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.473853e-01 0.072 0 0
Regulation of IFNG signaling R-HSA-877312 8.473853e-01 0.072 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.473853e-01 0.072 0 0
Signaling by LTK R-HSA-9842663 8.473853e-01 0.072 0 0
Interleukin-35 Signalling R-HSA-8984722 8.473853e-01 0.072 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.475839e-01 0.072 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.477616e-01 0.072 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.477616e-01 0.072 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.477616e-01 0.072 0 0
Signaling by SCF-KIT R-HSA-1433557 8.482377e-01 0.071 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.482377e-01 0.071 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.482377e-01 0.071 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.521881e-01 0.069 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.537424e-01 0.069 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.540271e-01 0.069 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.540271e-01 0.069 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.540271e-01 0.069 0 0
Hemostasis R-HSA-109582 8.556664e-01 0.068 0 0
Netrin-1 signaling R-HSA-373752 8.584691e-01 0.066 0 0
DAP12 interactions R-HSA-2172127 8.584691e-01 0.066 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.591849e-01 0.066 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.591849e-01 0.066 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.591849e-01 0.066 0 0
eNOS activation R-HSA-203615 8.591849e-01 0.066 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.591849e-01 0.066 0 0
Gap junction assembly R-HSA-190861 8.591849e-01 0.066 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.591849e-01 0.066 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.592630e-01 0.066 0 0
Signaling by NOTCH1 R-HSA-1980143 8.617354e-01 0.065 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 8.643111e-01 0.063 0 0
Chylomicron remodeling R-HSA-8963901 8.643111e-01 0.063 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.643111e-01 0.063 0 0
Processing of SMDT1 R-HSA-8949664 8.643111e-01 0.063 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.643111e-01 0.063 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.643111e-01 0.063 0 0
Formation of axial mesoderm R-HSA-9796292 8.643111e-01 0.063 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.643111e-01 0.063 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.643111e-01 0.063 0 0
Interleukin-6 signaling R-HSA-1059683 8.643111e-01 0.063 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.644719e-01 0.063 0 0
Signaling by Interleukins R-HSA-449147 8.646316e-01 0.063 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.647319e-01 0.063 0 0
Cellular response to chemical stress R-HSA-9711123 8.652285e-01 0.063 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.666198e-01 0.062 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.667616e-01 0.062 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.667616e-01 0.062 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.667616e-01 0.062 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.698492e-01 0.061 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.698492e-01 0.061 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.698492e-01 0.061 0 0
PERK regulates gene expression R-HSA-381042 8.698492e-01 0.061 0 0
Oncogene Induced Senescence R-HSA-2559585 8.698492e-01 0.061 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.698492e-01 0.061 0 0
ABC transporter disorders R-HSA-5619084 8.766494e-01 0.057 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.771731e-01 0.057 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.771731e-01 0.057 0 0
IRS-mediated signalling R-HSA-112399 8.778454e-01 0.057 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.784681e-01 0.056 0 0
Hyaluronan degradation R-HSA-2160916 8.784681e-01 0.056 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.784681e-01 0.056 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.784681e-01 0.056 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.793607e-01 0.056 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.793607e-01 0.056 0 0
HDL assembly R-HSA-8963896 8.793607e-01 0.056 0 0
Transport of fatty acids R-HSA-804914 8.793607e-01 0.056 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.793607e-01 0.056 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.793607e-01 0.056 0 0
Physiological factors R-HSA-5578768 8.793607e-01 0.056 0 0
Malate-aspartate shuttle R-HSA-9856872 8.793607e-01 0.056 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.793607e-01 0.056 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.793607e-01 0.056 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.793607e-01 0.056 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.797933e-01 0.056 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.846960e-01 0.053 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.892178e-01 0.051 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.892178e-01 0.051 0 0
Metalloprotease DUBs R-HSA-5689901 8.892178e-01 0.051 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.892178e-01 0.051 0 0
Sphingolipid catabolism R-HSA-9845614 8.892178e-01 0.051 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.892178e-01 0.051 0 0
Interferon alpha/beta signaling R-HSA-909733 8.895407e-01 0.051 0 0
tRNA processing R-HSA-72306 8.919540e-01 0.050 0 0
Erythropoietin activates RAS R-HSA-9027284 8.927418e-01 0.049 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.927418e-01 0.049 0 0
Protein lipoylation R-HSA-9857492 8.927418e-01 0.049 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.927418e-01 0.049 0 0
DCC mediated attractive signaling R-HSA-418885 8.927418e-01 0.049 0 0
DNA Damage Reversal R-HSA-73942 8.927418e-01 0.049 0 0
Transport and metabolism of PAPS R-HSA-174362 8.927418e-01 0.049 0 0
p38MAPK events R-HSA-171007 8.927418e-01 0.049 0 0
Signaling by Activin R-HSA-1502540 8.927418e-01 0.049 0 0
Interleukin-1 family signaling R-HSA-446652 8.949448e-01 0.048 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.976734e-01 0.047 0 0
Triglyceride biosynthesis R-HSA-75109 8.990789e-01 0.046 0 0
Insulin processing R-HSA-264876 8.990789e-01 0.046 0 0
Synthesis of PE R-HSA-1483213 8.990789e-01 0.046 0 0
Protein localization R-HSA-9609507 8.994514e-01 0.046 0 0
Metabolism of polyamines R-HSA-351202 9.000111e-01 0.046 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.012013e-01 0.045 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.046395e-01 0.044 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.046395e-01 0.044 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.046395e-01 0.044 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.046395e-01 0.044 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.046395e-01 0.044 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.046395e-01 0.044 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.046395e-01 0.044 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.046395e-01 0.044 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.046395e-01 0.044 0 0
Attachment and Entry R-HSA-9678110 9.046395e-01 0.044 0 0
Virus Assembly and Release R-HSA-168268 9.046395e-01 0.044 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.065807e-01 0.043 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.081163e-01 0.042 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.081669e-01 0.042 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.089774e-01 0.041 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.127699e-01 0.040 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.152180e-01 0.038 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.152180e-01 0.038 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.152180e-01 0.038 0 0
Phase 2 - plateau phase R-HSA-5576893 9.152180e-01 0.038 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.152180e-01 0.038 0 0
Passive transport by Aquaporins R-HSA-432047 9.152180e-01 0.038 0 0
Synthesis of PG R-HSA-1483148 9.152180e-01 0.038 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.152180e-01 0.038 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.152180e-01 0.038 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.152180e-01 0.038 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.152180e-01 0.038 0 0
SLC transporter disorders R-HSA-5619102 9.159474e-01 0.038 0 0
Adaptive Immune System R-HSA-1280218 9.163440e-01 0.038 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.200224e-01 0.036 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.209786e-01 0.036 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.239617e-01 0.034 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.239617e-01 0.034 0 0
Ion transport by P-type ATPases R-HSA-936837 9.240754e-01 0.034 0 0
IGF1R signaling cascade R-HSA-2428924 9.240754e-01 0.034 0 0
Insulin receptor signalling cascade R-HSA-74751 9.240754e-01 0.034 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.246235e-01 0.034 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.246235e-01 0.034 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.246235e-01 0.034 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.246235e-01 0.034 0 0
Catecholamine biosynthesis R-HSA-209905 9.246235e-01 0.034 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.246235e-01 0.034 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.264185e-01 0.033 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.264185e-01 0.033 0 0
Translation of Structural Proteins R-HSA-9683701 9.264185e-01 0.033 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.292251e-01 0.032 0 0
Cellular response to hypoxia R-HSA-1234174 9.292251e-01 0.032 0 0
Downstream signal transduction R-HSA-186763 9.308820e-01 0.031 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.308820e-01 0.031 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.323418e-01 0.030 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.329862e-01 0.030 0 0
PKA activation R-HSA-163615 9.329862e-01 0.030 0 0
PKA activation in glucagon signalling R-HSA-164378 9.329862e-01 0.030 0 0
Ephrin signaling R-HSA-3928664 9.329862e-01 0.030 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.330735e-01 0.030 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.372033e-01 0.028 0 0
Leishmania infection R-HSA-9658195 9.385133e-01 0.028 1 0
Parasitic Infection Pathways R-HSA-9824443 9.385133e-01 0.028 1 0
Germ layer formation at gastrulation R-HSA-9754189 9.404214e-01 0.027 0 0
Rap1 signalling R-HSA-392517 9.404214e-01 0.027 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.404214e-01 0.027 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.404214e-01 0.027 0 0
Diseases of hemostasis R-HSA-9671793 9.404214e-01 0.027 0 0
Transport of nucleotide sugars R-HSA-727802 9.404214e-01 0.027 0 0
Other interleukin signaling R-HSA-449836 9.404214e-01 0.027 0 0
Regulated Necrosis R-HSA-5218859 9.428544e-01 0.026 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.470321e-01 0.024 0 0
Creatine metabolism R-HSA-71288 9.470321e-01 0.024 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.470321e-01 0.024 0 0
Signaling by NODAL R-HSA-1181150 9.470321e-01 0.024 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.482364e-01 0.023 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.482364e-01 0.023 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.482364e-01 0.023 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.485454e-01 0.023 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.502192e-01 0.022 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.503121e-01 0.022 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.508798e-01 0.022 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.518954e-01 0.021 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.518954e-01 0.021 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.529097e-01 0.021 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.529097e-01 0.021 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.529097e-01 0.021 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.529097e-01 0.021 0 0
Signalling to RAS R-HSA-167044 9.529097e-01 0.021 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.529097e-01 0.021 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.529097e-01 0.021 0 0
Signaling by NOTCH2 R-HSA-1980145 9.530341e-01 0.021 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.530341e-01 0.021 0 0
Hyaluronan metabolism R-HSA-2142845 9.530341e-01 0.021 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.530341e-01 0.021 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.530341e-01 0.021 1 1
Triglyceride metabolism R-HSA-8979227 9.539935e-01 0.020 0 0
Regulation of beta-cell development R-HSA-186712 9.539935e-01 0.020 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.541020e-01 0.020 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.552421e-01 0.020 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.556994e-01 0.020 0 0
Parasite infection R-HSA-9664407 9.556994e-01 0.020 0 0
Leishmania phagocytosis R-HSA-9664417 9.556994e-01 0.020 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.558833e-01 0.020 0 0
Cardiac conduction R-HSA-5576891 9.572779e-01 0.019 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.575024e-01 0.019 0 0
CS-GAG biosynthesis R-HSA-2022870 9.581353e-01 0.019 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.581353e-01 0.019 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.581353e-01 0.019 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.581353e-01 0.019 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.581353e-01 0.019 0 0
Glutathione synthesis and recycling R-HSA-174403 9.581353e-01 0.019 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.581353e-01 0.019 0 0
Assembly Of The HIV Virion R-HSA-175474 9.581353e-01 0.019 0 0
Neddylation R-HSA-8951664 9.584238e-01 0.018 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.595599e-01 0.018 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.596435e-01 0.018 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.613842e-01 0.017 0 0
Triglyceride catabolism R-HSA-163560 9.613842e-01 0.017 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.613842e-01 0.017 0 0
Transmission across Chemical Synapses R-HSA-112315 9.620271e-01 0.017 0 0
Neuronal System R-HSA-112316 9.624433e-01 0.017 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.627813e-01 0.016 0 0
Cellular hexose transport R-HSA-189200 9.627813e-01 0.016 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.627813e-01 0.016 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.627813e-01 0.016 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.627813e-01 0.016 0 0
Signaling by PDGF R-HSA-186797 9.637894e-01 0.016 0 0
Phospholipid metabolism R-HSA-1483257 9.645354e-01 0.016 0 0
Voltage gated Potassium channels R-HSA-1296072 9.650052e-01 0.015 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.650052e-01 0.015 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.659028e-01 0.015 0 0
Iron uptake and transport R-HSA-917937 9.659028e-01 0.015 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.669120e-01 0.015 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.669120e-01 0.015 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.669120e-01 0.015 0 0
Carnitine shuttle R-HSA-200425 9.669120e-01 0.015 0 0
Potassium Channels R-HSA-1296071 9.671137e-01 0.015 0 0
Elastic fibre formation R-HSA-1566948 9.682984e-01 0.014 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.682984e-01 0.014 0 0
The phototransduction cascade R-HSA-2514856 9.689362e-01 0.014 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.705844e-01 0.013 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.705844e-01 0.013 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.705844e-01 0.013 0 0
Interleukin-6 family signaling R-HSA-6783589 9.705844e-01 0.013 0 0
Post-translational protein modification R-HSA-597592 9.706762e-01 0.013 0 0
Translation of Structural Proteins R-HSA-9694635 9.707005e-01 0.013 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.712920e-01 0.013 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.738495e-01 0.012 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.738495e-01 0.012 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.738495e-01 0.012 0 0
Formation of the nephric duct R-HSA-9830364 9.738495e-01 0.012 0 0
Interleukin-2 family signaling R-HSA-451927 9.740118e-01 0.011 0 0
Neurotransmitter release cycle R-HSA-112310 9.746560e-01 0.011 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.746560e-01 0.011 0 0
Gastrulation R-HSA-9758941 9.746815e-01 0.011 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.759223e-01 0.011 0 0
Maturation of spike protein R-HSA-9694548 9.764817e-01 0.010 0 0
MET activates PTK2 signaling R-HSA-8874081 9.767523e-01 0.010 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.767523e-01 0.010 0 0
Urea cycle R-HSA-70635 9.767523e-01 0.010 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.767523e-01 0.010 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.787238e-01 0.009 0 0
Developmental Biology R-HSA-1266738 9.791762e-01 0.009 0 0
Signaling by BMP R-HSA-201451 9.793330e-01 0.009 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.793330e-01 0.009 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.793330e-01 0.009 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.793330e-01 0.009 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.793330e-01 0.009 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.796081e-01 0.009 0 0
Signaling by Insulin receptor R-HSA-74752 9.796617e-01 0.009 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.796617e-01 0.009 0 0
Formation of the cornified envelope R-HSA-6809371 9.807328e-01 0.008 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.807580e-01 0.008 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.811145e-01 0.008 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.812448e-01 0.008 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.816274e-01 0.008 0 0
Insulin receptor recycling R-HSA-77387 9.816274e-01 0.008 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.816274e-01 0.008 0 0
Pyrimidine salvage R-HSA-73614 9.816274e-01 0.008 0 0
Pyrimidine catabolism R-HSA-73621 9.826030e-01 0.008 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.836672e-01 0.007 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.836672e-01 0.007 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.836672e-01 0.007 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.836672e-01 0.007 0 0
Purine catabolism R-HSA-74259 9.841527e-01 0.007 0 0
Peroxisomal protein import R-HSA-9033241 9.849000e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.849000e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.854806e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.862247e-01 0.006 0 0
Budding and maturation of HIV virion R-HSA-162588 9.870928e-01 0.006 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.870928e-01 0.006 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.870928e-01 0.006 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.870928e-01 0.006 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.888679e-01 0.005 1 0
Leishmania parasite growth and survival R-HSA-9664433 9.888679e-01 0.005 1 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.898002e-01 0.004 0 0
Recycling of bile acids and salts R-HSA-159418 9.898002e-01 0.004 0 0
Cardiogenesis R-HSA-9733709 9.898002e-01 0.004 0 0
Integrin cell surface interactions R-HSA-216083 9.905218e-01 0.004 0 0
Interleukin-10 signaling R-HSA-6783783 9.905218e-01 0.004 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.905524e-01 0.004 0 0
CS/DS degradation R-HSA-2024101 9.909329e-01 0.004 0 0
Heme degradation R-HSA-189483 9.909329e-01 0.004 0 0
Developmental Cell Lineages R-HSA-9734767 9.910176e-01 0.004 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.914740e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.919399e-01 0.004 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.923076e-01 0.003 0 0
Kidney development R-HSA-9830369 9.928210e-01 0.003 0 0
RSV-host interactions R-HSA-9833110 9.930212e-01 0.003 0 0
Infectious disease R-HSA-5663205 9.934279e-01 0.003 1 0
Mitochondrial protein degradation R-HSA-9837999 9.935745e-01 0.003 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.937801e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.943385e-01 0.002 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.943385e-01 0.002 0 0
Metabolism of proteins R-HSA-392499 9.944309e-01 0.002 0 0
Immune System R-HSA-168256 9.947273e-01 0.002 0 0
Stimuli-sensing channels R-HSA-2672351 9.949184e-01 0.002 0 0
Purine salvage R-HSA-74217 9.949674e-01 0.002 0 0
Mitochondrial translation elongation R-HSA-5389840 9.949988e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.950849e-01 0.002 0 0
Pentose phosphate pathway R-HSA-71336 9.955265e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.957096e-01 0.002 0 0
Mitochondrial translation initiation R-HSA-5368286 9.957745e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.960235e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.960235e-01 0.002 0 0
Glycogen metabolism R-HSA-8982491 9.960235e-01 0.002 0 0
Pyruvate metabolism R-HSA-70268 9.960770e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.964653e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.966480e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.966489e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.971624e-01 0.001 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.972407e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.972818e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.972818e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.974920e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.975176e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.975522e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.977934e-01 0.001 0 0
Amine ligand-binding receptors R-HSA-375280 9.977934e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.977973e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.980387e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.980387e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.983596e-01 0.001 0 0
Mitochondrial translation termination R-HSA-5419276 9.984969e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.985888e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.987758e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.989119e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.990329e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.990329e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.992105e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.992360e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.992598e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.992957e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.992957e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.993075e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.993148e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.993813e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.993965e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.993965e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.994242e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.994636e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.994636e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.995096e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.995232e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.995232e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.995761e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.996133e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.996234e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.996653e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.996653e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.997025e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997190e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.997505e-01 0.000 0 0
Disease R-HSA-1643685 9.998073e-01 0.000 1 0
Nicotinate metabolism R-HSA-196807 9.998534e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998534e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.998570e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.998697e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998743e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.998995e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999086e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999086e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999215e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999278e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.999304e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999321e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999387e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999447e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999671e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999719e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999719e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999752e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999768e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999857e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999862e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999902e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999912e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999945e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999946e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999949e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999950e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999963e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999973e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999978e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999987e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999988e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999992e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999994e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999995e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999996e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999996e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999997e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways