EEF2K

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00418 S135 Sugiyama EEF2K HRYNAVTGEWLDDEVLIKMAsQPFGRGAMRECFRTKKLSNF
O00418 S241 Sugiyama EEF2K PGKPLFHLEHYIEGKYIKYNsNsGFVRDDNIRLTPQAFSHF
O00418 S243 Sugiyama EEF2K KPLFHLEHYIEGKYIKYNsNsGFVRDDNIRLTPQAFSHFTF
O00418 S366 EPSD|PSP EEF2K AKtILRGtEEKCGsPQVRTLsGSRPPLLRPLsENSGDENMS
O00418 S396 EPSD|PSP EEF2K LsENSGDENMSDVTFDsLPSsPsSATPHSQKLDHLHWPVFS
O00418 S441 EPSD|PSP EEF2K MASRDHDHLDNHRESENSGDsGYPsEKRGELDDPEPREHGH
O00418 S445 SIGNOR|EPSD|PSP EEF2K DHDHLDNHRESENSGDsGYPsEKRGELDDPEPREHGHsYsN
O00418 S474 EPSD|PSP|Sugiyama EEF2K PEPREHGHsYsNRKyEsDEDsLGssGRVCVEKWNLLNssRL
O00418 S478 Sugiyama EEF2K EHGHsYsNRKyEsDEDsLGssGRVCVEKWNLLNssRLHLPR
O00418 S491 Sugiyama EEF2K DEDsLGssGRVCVEKWNLLNssRLHLPRAsAVALEVQRLNA
O00418 S500 EPSD|PSP|Sugiyama EEF2K RVCVEKWNLLNssRLHLPRAsAVALEVQRLNALDLEKKIGK
O00418 S622 Sugiyama EEF2K LKAAEAGDRQSMILVARAFDsGQNLsPDRCQDWLEALHWYN
O00418 S66 Sugiyama EEF2K PSSNQNVNSKVNKYysNLtKsERysssGsPANsFHFKEAWK
O00418 S70 Sugiyama EEF2K QNVNSKVNKYysNLtKsERysssGsPANsFHFKEAWKHAIQ
O00418 S71 Sugiyama EEF2K NVNSKVNKYysNLtKsERysssGsPANsFHFKEAWKHAIQK
O00418 S72 Sugiyama EEF2K VNSKVNKYysNLtKsERysssGsPANsFHFKEAWKHAIQKA
O00418 S74 Sugiyama EEF2K SKVNKYysNLtKsERysssGsPANsFHFKEAWKHAIQKAKH
O00418 S78 PSP|Sugiyama EEF2K KYysNLtKsERysssGsPANsFHFKEAWKHAIQKAKHMPDP
O00418 T348 EPSD|PSP EEF2K LSPRERDAVNQNTKLLQSAKtILRGtEEKCGsPQVRTLsGS
O00418 T353 EPSD|PSP EEF2K RDAVNQNTKLLQSAKtILRGtEEKCGsPQVRTLsGSRPPLL
O00418 T64 Sugiyama EEF2K DDPSSNQNVNSKVNKYysNLtKsERysssGsPANsFHFKEA
O15371 T49 Sugiyama EIF3D EIF3S7 PyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQY
O43242 T69 Sugiyama PSMD3 GEADGKtAAAAAEHsQRELDtVtLEDIKEHVKQLEKAVSGK
O60664 S93 Sugiyama PLIN3 M6PRBP1 TIP47 AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O75821 T206 Sugiyama EIF3G EIF3S4 LGLstGEKEKLPGELEPVQAtQNKtGKYVPPsLRDGAsRRG
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04075 S17 Sugiyama ALDOA ALDA ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 T52 Sugiyama ALDOA ALDA AADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDRVNP
P04083 T64 Sugiyama ANXA1 ANX1 LPC1 PssDVAALHKAIMVKGVDEAtIIDILtKRNNAQRQQIKAAY
P04083 T70 Sugiyama ANXA1 ANX1 LPC1 ALHKAIMVKGVDEAtIIDILtKRNNAQRQQIKAAYLQEtGK
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198 T284 Sugiyama EIF2S1 EIF2A EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 T18 Sugiyama LDHB ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07237 T85 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 T637 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MGyMMAKKHLEINPDHPIVEtLRQKAEADKNDKAVKDLVVL
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11586 T128 Sugiyama MTHFD1 MTHFC MTHFD SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P13639 T54 iPTMNet|EPSD EEF2 EF2 tLtDsLVCKAGIIAsARAGEtRFtDtRKDEQERCITIKSTA
P13639 T57 SIGNOR|iPTMNet|EPSD|PSP EEF2 EF2 DsLVCKAGIIAsARAGEtRFtDtRKDEQERCITIKSTAISL
P13639 T59 SIGNOR|iPTMNet|EPSD EEF2 EF2 LVCKAGIIAsARAGEtRFtDtRKDEQERCITIKSTAISLFY
P13639 T724 Sugiyama EEF2 EF2 VHDVTLHADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPI
P13929 T26 Sugiyama ENO3 IFAREILDsRGNPtVEVDLHtAKGRFRAAVPsGAstGIyEA
P14314 T115 Sugiyama PRKCSH G19P1 GVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQQMAEVtR
P14618 T129 PSP PKM OIP3 PK2 PK3 PKM2 AVALDTKGPEIRtGLIKGsGtAEVELKKGATLKITLDNAyM
P14618 T41 Sugiyama PKM OIP3 PK2 PK3 PKM2 AMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtL
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P18124 T17 Sugiyama RPL7 ____MEGVEEKKKEVPAVPEtLKKKRRNFAELKIKRLRKKF
P18621 T12 Sugiyama RPL17 _________MVRysLDPENPtKsCKSRGSNLRVHFKNtRET
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 T452 Sugiyama NCL AyIEFKTEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQD
P20042 T31 Sugiyama EIF2S2 EIF2B tMsKKKKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtED
P22314 T1016 Sugiyama UBA1 A1S9T UBE1 MLYSFFMPAAKLKERLDQPMtEIVsRVSKRKLGRHVRALVL
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P23396 T221 Sugiyama RPS3 OK/SW-cl.26 KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P24752 T220 Sugiyama ACAT1 ACAT MAT TAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPVtV
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038 T425 Sugiyama MSN QAsRDQKKTQEQLALEMAELtARIsQLEMARQKKEsEAVEW
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P31327 T54 Sugiyama CPS1 PGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPSSVAGEVVFN
P31327 T903 Sugiyama CPS1 DILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQISKCLGL
P31948 T243 Sugiyama STIP1 KQALKEKELGNDAYKKKDFDtALKHYDKAKELDPtNMtyIT
P33176 T809 Sugiyama KIF5B KNS KNS1 VAKELQTLHNLRKLFVQDLAtRVKKSAEIDsDDTGGsAAQK
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P35241 T425 Sugiyama RDX KQAADQMKNQEQLAAELAEFtAKIALLEEAKKKKEEEATEW
P35579 T1208 Sugiyama MYH9 QEMRQKHsQAVEELAEQLEQtKRVKANLEKAKQtLENERGE
P35579 T1904 Sugiyama MYH9 EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35579 T1906 Sugiyama MYH9 AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P35580 T1911 Sugiyama MYH10 EEATRANASRRKLQRELDDAtEANEGLSREVSTLKNRLRRG
P35613 S279 Sugiyama BSG UNQ6505/PRO21383 TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P35637 S346 Sugiyama FUS TLS TDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKEFsGNPIKV
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P40763 Y705 PSP STAT3 APRF KyCRPEsQEHPEADPGsAAPyLKTKFICVtPttCsNtIDLP
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46783 T148 Sugiyama RPS10 RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49841 S9 PSP GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P50914 T43 Sugiyama RPL14 KLVAIVDVIDQNRALVDGPCtQVRRQAMPFKCMQLTDFILK
P53999 S19 Sugiyama SUB1 PC4 RPO2TC1 __MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPVKK
P53999 S56 Sugiyama SUB1 PC4 RPO2TC1 PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174 T38 Sugiyama TPI1 TPI RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174 T46 Sugiyama TPI1 TPI IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61247 S192 Sugiyama RPS3A FTE1 MFTL MTREVQTNDLKEVVNKLIPDsIGKDIEKACQsIyPLHDVFV
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S237 Sugiyama RPS3A FTE1 MFTL MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 T94 Sugiyama RPL27 VyNyNHLMPtRysVDIPLDKtVVNKDVFRDPALKRKARREA
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62263 T140 Sugiyama RPS14 PRO2640 ARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL_________
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62424 T93 Sugiyama RPL7A SURF-3 SURF3 RLKVPPAINQFtQALDRQTAtQLLKLAHKYRPEtKQEKKQR
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62750 T126 Sugiyama RPL23A KHQIKQAVKKLyDIDVAKVNtLIRPDGEKKAYVRLAPDyDA
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62899 T119 Sugiyama RPL31 PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T143 Sugiyama RPL8 RGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANR
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63167 T26 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 T89 Sugiyama YBX1 NSEP1 YB1 RNGyGFINRNDtKEDVFVHQtAIKKNNPRKyLRsVGDGEtV
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q02543 T107 Sugiyama RPL18A RSGtHNMYREyRDLttAGAVtQCyRDMGARHRARAHsIQIM
Q04760 T35 Sugiyama GLO1 AALSCCSDADPSTKDFLLQQtMLRVKDPKKSLDFyTRVLGM
Q06830 S32 Sugiyama PRDX1 PAGA PAGB TDPX2 APNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTFVC
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q14103 T91 Sugiyama HNRNPD AUF1 HNRPD sKNEEDEGHsNssPRHsEAAtAQREEWKMFIGGLSWDTTKK
Q14152 S1256 Sugiyama EIF3A EIF3S10 KIAA0139 EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14152 T1378 Sugiyama EIF3A EIF3S10 KIAA0139 AEKDREsLRRTKNEtDEDGWttVRR________________
Q14152 T1379 Sugiyama EIF3A EIF3S10 KIAA0139 EKDREsLRRTKNEtDEDGWttVRR_________________
Q14444 T303 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14677 T271 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 KDEEETVTTKHIHItQATEttttRHKRTANPsKtIDLGAAA
Q15029 T811 Sugiyama EFTUD2 KIAA0031 SNRP116 ILDAVVAQEPLHRGGGQIIPtARRVVYSAFLMATPRLMEPY
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q16658 S234 Sugiyama FSCN1 FAN1 HSN SNL LEFRsGKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELF
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6UXH1 T300 Sugiyama CRELD2 UNQ185/PRO211 GYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSYVCVCP
Q92804 S295 Sugiyama TAF15 RBP56 TAF2N TDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKEFHGNIIKV
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q96G46 T99 Sugiyama DUS3L DGQtADGQtEEAAEPGEQLQtQKRARGQNKGRPHVKPTNYD
Q96HE7 T148 Sugiyama ERO1A ERO1L UNQ434/PRO865 IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q96QK1 T763 Sugiyama VPS35 MEM3 TCCCTA00141 LNQLIQKIREDLPNLEssEEtEQINKHFHNtLEHLRLRREs
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQ39 T159 Sugiyama RPS10P5 RPS10L RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NUQ3 T90 Sugiyama TXLNG CXorf15 ELRG LSR5 NCGGTSNKHSLEEDEGsDFItENRNLVsPAyCtQEsREEIP
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2B0 T100 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 ELLEEICDRMKEyGEQIDPstHRKNYVRVVGRNGEssELDL
Q9Y2T7 T124 Sugiyama YBX2 CSDA3 MSY2 RNGyGFINRNDtKEDVFVHQtAIKRNNPRKFLRsVGDGEtV
Q9Y2W1 S232 Sugiyama THRAP3 BCLAF2 TRAP150 QDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERsPALK
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 1.109899e-06 5.955 0 0
Apoptotic execution phase R-HSA-75153 7.765927e-07 6.110 0 0
Signal Transduction R-HSA-162582 1.092749e-06 5.961 1 0
Nervous system development R-HSA-9675108 1.348033e-06 5.870 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.179207e-06 5.662 0 0
mRNA Splicing R-HSA-72172 5.266922e-06 5.278 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.425533e-06 5.192 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.726104e-06 5.172 0 0
Cell Cycle R-HSA-1640170 1.527117e-05 4.816 0 0
Metabolism of RNA R-HSA-8953854 3.006632e-05 4.522 0 0
Mitotic Anaphase R-HSA-68882 3.517051e-05 4.454 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.760834e-05 4.425 0 0
EPH-Ephrin signaling R-HSA-2682334 4.007661e-05 4.397 0 0
Signaling by Hippo R-HSA-2028269 5.024046e-05 4.299 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.852413e-05 4.233 0 0
Cell Cycle, Mitotic R-HSA-69278 1.104703e-04 3.957 0 0
M Phase R-HSA-68886 2.911466e-04 3.536 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.865589e-04 3.413 0 0
Ephrin signaling R-HSA-3928664 4.917119e-04 3.308 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.303041e-04 3.275 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.400426e-04 3.268 0 0
MAPK family signaling cascades R-HSA-5683057 5.549779e-04 3.256 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.218164e-04 3.142 0 0
GPER1 signaling R-HSA-9634597 7.331236e-04 3.135 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.889908e-04 3.103 0 0
Signaling by NTRKs R-HSA-166520 8.639171e-04 3.064 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.256664e-04 3.034 0 0
Semaphorin interactions R-HSA-373755 1.028075e-03 2.988 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.118551e-03 2.951 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.261072e-03 2.899 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 1.387713e-03 2.858 0 0
Integrin signaling R-HSA-354192 1.505099e-03 2.822 0 0
Striated Muscle Contraction R-HSA-390522 1.734200e-03 2.761 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.802007e-03 2.744 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.760203e-03 2.754 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.084725e-03 2.681 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.126894e-03 2.672 0 0
Apoptosis R-HSA-109581 2.012301e-03 2.696 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.138135e-03 2.670 0 0
Oncogene Induced Senescence R-HSA-2559585 2.272950e-03 2.643 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.508224e-03 2.601 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.508224e-03 2.601 0 0
Signaling by ERBB2 R-HSA-1227986 2.718395e-03 2.566 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.024434e-03 2.519 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.089101e-03 2.510 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.976443e-03 2.401 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.015804e-03 2.396 0 0
Cell Cycle Checkpoints R-HSA-69620 4.184774e-03 2.378 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.463273e-03 2.350 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.921309e-03 2.308 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.921309e-03 2.308 0 0
Separation of Sister Chromatids R-HSA-2467813 5.263131e-03 2.279 0 0
Signaling by LTK R-HSA-9842663 4.982067e-03 2.303 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.718026e-03 2.326 0 0
Cellular Senescence R-HSA-2559583 5.404044e-03 2.267 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.295622e-03 2.276 0 0
Signaling by ALK in cancer R-HSA-9700206 5.295622e-03 2.276 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.921309e-03 2.308 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.145357e-03 2.211 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.118337e-03 2.148 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 9.037792e-03 2.044 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.640809e-03 2.063 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.640809e-03 2.063 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.640809e-03 2.063 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.859666e-03 2.105 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.852387e-03 2.105 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.984129e-03 2.047 0 0
Mitophagy R-HSA-5205647 8.429726e-03 2.074 0 0
Signaling by RAS mutants R-HSA-6802949 8.640809e-03 2.063 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.812916e-03 2.107 0 0
Selective autophagy R-HSA-9663891 9.001364e-03 2.046 0 0
Regulation of KIT signaling R-HSA-1433559 7.476277e-03 2.126 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.893454e-03 2.051 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.661842e-03 2.062 0 0
Signal amplification R-HSA-392518 8.429726e-03 2.074 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.429726e-03 2.074 0 0
Programmed Cell Death R-HSA-5357801 8.132172e-03 2.090 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.643245e-03 2.016 0 0
Regulation of TP53 Activity R-HSA-5633007 9.675824e-03 2.014 0 0
Mitotic Prometaphase R-HSA-68877 9.712793e-03 2.013 0 0
Type I hemidesmosome assembly R-HSA-446107 1.166571e-02 1.933 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.166571e-02 1.933 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.166571e-02 1.933 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.161162e-02 1.935 0 0
Degradation of CDH1 R-HSA-9766229 1.135475e-02 1.945 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.139598e-02 1.943 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.068563e-02 1.971 0 0
Muscle contraction R-HSA-397014 1.084105e-02 1.965 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.166571e-02 1.933 0 0
L1CAM interactions R-HSA-373760 1.019720e-02 1.992 0 0
Regulation of TP53 Expression R-HSA-6804754 1.263582e-02 1.898 0 0
Mitotic Prophase R-HSA-68875 1.266310e-02 1.897 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.325586e-02 1.878 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.365785e-02 1.865 0 0
mRNA 3'-end processing R-HSA-72187 1.463791e-02 1.835 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.415277e-02 1.849 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.468850e-02 1.833 0 0
Signaling by ROBO receptors R-HSA-376176 1.460770e-02 1.835 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.498012e-02 1.824 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.533363e-02 1.814 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.578485e-02 1.802 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.811319e-02 1.742 0 0
Signal attenuation R-HSA-74749 1.811319e-02 1.742 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.694587e-02 1.771 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.758125e-02 1.755 0 0
Regulation of CDH11 function R-HSA-9762292 1.811319e-02 1.742 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.758125e-02 1.755 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.811319e-02 1.742 0 0
Signaling by VEGF R-HSA-194138 1.718705e-02 1.765 0 0
Cell-Cell communication R-HSA-1500931 1.723367e-02 1.764 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.705765e-02 1.768 0 0
MAP2K and MAPK activation R-HSA-5674135 1.865347e-02 1.729 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.908504e-02 1.719 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.920780e-02 1.717 0 0
Rap1 signalling R-HSA-392517 1.945260e-02 1.711 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.152179e-02 1.667 0 0
Activation of GABAB receptors R-HSA-991365 2.034838e-02 1.691 0 0
GABA B receptor activation R-HSA-977444 2.034838e-02 1.691 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.152179e-02 1.667 0 0
Regulation of CDH1 Function R-HSA-9764561 2.152844e-02 1.667 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.194374e-02 1.659 0 0
PECAM1 interactions R-HSA-210990 2.194374e-02 1.659 0 0
Regulation of gap junction activity R-HSA-191650 2.691148e-02 1.570 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.691148e-02 1.570 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.576548e-02 1.589 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 2.512211e-02 1.600 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.691148e-02 1.570 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.653565e-02 1.576 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.575522e-02 1.589 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.615124e-02 1.583 0 0
Interleukin-12 signaling R-HSA-9020591 2.761312e-02 1.559 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.828553e-02 1.548 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.829229e-02 1.548 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.829229e-02 1.548 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.845485e-02 1.546 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.033548e-02 1.518 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.039145e-02 1.517 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.082493e-02 1.511 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.095650e-02 1.509 0 0
RAF activation R-HSA-5673000 3.095650e-02 1.509 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.095650e-02 1.509 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.272833e-02 1.485 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.156093e-02 1.501 0 0
Autophagy R-HSA-9612973 3.545180e-02 1.450 0 0
DNA Repair R-HSA-73894 3.439963e-02 1.463 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.242635e-02 1.489 0 0
Signaling by PTK6 R-HSA-8848021 3.242635e-02 1.489 0 0
IRS activation R-HSA-74713 3.564279e-02 1.448 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.564279e-02 1.448 0 0
NrCAM interactions R-HSA-447038 3.564279e-02 1.448 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 4.117160e-02 1.385 0 0
PDGFR mutants bind TKIs R-HSA-9674428 4.117160e-02 1.385 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 4.117160e-02 1.385 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 4.117160e-02 1.385 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 4.117160e-02 1.385 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 4.117160e-02 1.385 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 4.117160e-02 1.385 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 4.117160e-02 1.385 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 4.117160e-02 1.385 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.131427e-02 1.384 0 0
Deadenylation of mRNA R-HSA-429947 3.917349e-02 1.407 0 0
RET signaling R-HSA-8853659 3.675945e-02 1.435 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.675945e-02 1.435 0 0
rRNA processing R-HSA-72312 4.111129e-02 1.386 0 0
Chromatin organization R-HSA-4839726 3.883827e-02 1.411 0 0
Macroautophagy R-HSA-1632852 3.803863e-02 1.420 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.955025e-02 1.403 0 0
G-protein mediated events R-HSA-112040 4.144159e-02 1.383 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.322607e-02 1.364 0 0
Chromatin modifying enzymes R-HSA-3247509 4.365705e-02 1.360 0 0
Developmental Biology R-HSA-1266738 4.407580e-02 1.356 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.714773e-02 1.327 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.714773e-02 1.327 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.714773e-02 1.327 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.663942e-02 1.331 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.025028e-02 1.299 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.212853e-02 1.283 0 0
Adipogenesis R-HSA-9843745 4.970451e-02 1.304 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.025028e-02 1.299 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.025028e-02 1.299 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.212853e-02 1.283 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.530432e-02 1.344 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.530432e-02 1.344 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.714773e-02 1.327 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.212853e-02 1.283 0 0
ESR-mediated signaling R-HSA-8939211 4.768456e-02 1.322 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.530432e-02 1.344 0 0
Cell junction organization R-HSA-446728 5.111407e-02 1.291 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.793955e-02 1.319 0 0
Cellular responses to stress R-HSA-2262752 4.894559e-02 1.310 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.663942e-02 1.331 0 0
Cellular responses to stimuli R-HSA-8953897 4.777782e-02 1.321 0 0
Interleukin-12 family signaling R-HSA-447115 5.276570e-02 1.278 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.336286e-02 1.273 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.336286e-02 1.273 0 0
Peptide chain elongation R-HSA-156902 5.536182e-02 1.257 0 0
Gene expression (Transcription) R-HSA-74160 5.543074e-02 1.256 0 0
Signaling by EGFR R-HSA-177929 5.561906e-02 1.255 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.580492e-02 1.253 0 0
Nef and signal transduction R-HSA-164944 5.580492e-02 1.253 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.580492e-02 1.253 0 0
Pyroptosis R-HSA-5620971 5.690566e-02 1.245 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.795091e-02 1.237 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 8.065051e-02 1.093 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.065051e-02 1.093 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.065051e-02 1.093 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.065051e-02 1.093 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.065051e-02 1.093 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 8.065051e-02 1.093 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 8.065051e-02 1.093 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.065051e-02 1.093 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 8.065051e-02 1.093 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 8.065051e-02 1.093 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 8.065051e-02 1.093 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 8.065051e-02 1.093 0 0
SOS-mediated signalling R-HSA-112412 6.705932e-02 1.174 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.898787e-02 1.102 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.689777e-02 1.175 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.419469e-02 1.130 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.182788e-02 1.087 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.978394e-02 1.047 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.978394e-02 1.047 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.978394e-02 1.047 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.978394e-02 1.047 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.190945e-02 1.208 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.713745e-02 1.173 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.258669e-02 1.139 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.258669e-02 1.139 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.825376e-02 1.106 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.413478e-02 1.075 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.403582e-02 1.131 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.403582e-02 1.131 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.363209e-02 1.196 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.655071e-02 1.177 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.904025e-02 1.102 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.236673e-02 1.084 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.540861e-02 1.123 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.540861e-02 1.123 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.540861e-02 1.123 0 0
Chromosome Maintenance R-HSA-73886 6.259427e-02 1.203 0 0
Nephrin family interactions R-HSA-373753 8.978394e-02 1.047 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.419469e-02 1.130 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.705932e-02 1.174 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.345618e-02 1.198 0 0
Recycling pathway of L1 R-HSA-437239 8.485461e-02 1.071 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.618333e-02 1.179 0 0
Eukaryotic Translation Termination R-HSA-72764 8.236673e-02 1.084 0 0
GABA receptor activation R-HSA-977443 6.994762e-02 1.155 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.082786e-02 1.216 0 0
Co-stimulation by CD28 R-HSA-389356 8.988187e-02 1.046 0 0
Trafficking of AMPA receptors R-HSA-399719 7.258669e-02 1.139 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.579540e-02 1.120 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.955070e-02 1.158 0 0
Regulation of signaling by CBL R-HSA-912631 8.182788e-02 1.087 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.190945e-02 1.208 0 0
Signaling by FGFR2 R-HSA-5654738 8.122594e-02 1.090 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.978394e-02 1.047 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 9.022546e-02 1.045 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.413478e-02 1.075 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.069598e-02 1.151 0 0
Signaling by FGFR4 R-HSA-5654743 6.628913e-02 1.179 0 0
Signaling by FGFR3 R-HSA-5654741 7.526005e-02 1.123 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.783934e-02 1.109 0 0
Diseases of DNA repair R-HSA-9675135 7.998009e-02 1.097 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.182788e-02 1.087 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.974833e-02 1.047 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.413478e-02 1.075 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.561724e-02 1.183 0 0
MECP2 regulates transcription factors R-HSA-9022707 6.705932e-02 1.174 0 0
Adrenoceptors R-HSA-390696 7.898787e-02 1.102 0 0
Signaling by MET R-HSA-6806834 8.122594e-02 1.090 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.413478e-02 1.075 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.994762e-02 1.155 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.003354e-02 1.046 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.526005e-02 1.123 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.413478e-02 1.075 0 0
Influenza Infection R-HSA-168255 7.941025e-02 1.100 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.363209e-02 1.196 0 0
WNT mediated activation of DVL R-HSA-201688 9.151615e-02 1.039 0 0
ALK mutants bind TKIs R-HSA-9700645 9.151615e-02 1.039 0 0
ARMS-mediated activation R-HSA-170984 9.151615e-02 1.039 0 0
GP1b-IX-V activation signalling R-HSA-430116 9.151615e-02 1.039 0 0
Developmental Cell Lineages R-HSA-9734767 9.393260e-02 1.027 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.652115e-02 1.015 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.652115e-02 1.015 0 0
Nuclear import of Rev protein R-HSA-180746 9.652115e-02 1.015 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.804889e-02 1.009 0 0
RNA Polymerase II Transcription R-HSA-73857 9.929829e-02 1.003 0 0
Glycolysis R-HSA-70171 1.002180e-01 0.999 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.185062e-01 0.926 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.185062e-01 0.926 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.185062e-01 0.926 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.185062e-01 0.926 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.045747e-01 0.981 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.045747e-01 0.981 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.180989e-01 0.928 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.320282e-01 0.879 0 0
Notch-HLH transcription pathway R-HSA-350054 1.154475e-01 0.938 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.339048e-01 0.873 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.030168e-01 0.987 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.097072e-01 0.960 0 0
Meiotic synapsis R-HSA-1221632 1.172335e-01 0.931 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.191976e-01 0.924 0 0
Viral mRNA Translation R-HSA-192823 1.118921e-01 0.951 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.329076e-01 0.876 0 0
Ribosome-associated quality control R-HSA-9948299 1.229967e-01 0.910 0 0
Cellular response to heat stress R-HSA-3371556 1.202442e-01 0.920 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.339048e-01 0.873 0 0
PI3K/AKT activation R-HSA-198203 1.045747e-01 0.981 0 0
Stabilization of p53 R-HSA-69541 1.308888e-01 0.883 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.154475e-01 0.938 0 0
Neurodegenerative Diseases R-HSA-8863678 1.339048e-01 0.873 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.339048e-01 0.873 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.030168e-01 0.987 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.236491e-01 0.908 0 0
Meiosis R-HSA-1500620 1.008957e-01 0.996 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.154475e-01 0.938 0 0
Signalling to ERKs R-HSA-187687 1.030168e-01 0.987 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.158658e-01 0.936 0 0
Diseases of programmed cell death R-HSA-9645723 1.183361e-01 0.927 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.185062e-01 0.926 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.045747e-01 0.981 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.180989e-01 0.928 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.165866e-01 0.933 0 0
MET promotes cell motility R-HSA-8875878 1.236491e-01 0.908 0 0
Membrane Trafficking R-HSA-199991 1.120924e-01 0.950 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.045747e-01 0.981 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.245514e-01 0.905 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.066083e-01 0.972 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.185062e-01 0.926 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.154475e-01 0.938 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.079215e-01 0.967 0 0
Ub-specific processing proteases R-HSA-5689880 1.158912e-01 0.936 0 0
RUNX2 regulates bone development R-HSA-8941326 1.097072e-01 0.960 0 0
Opioid Signalling R-HSA-111885 1.159412e-01 0.936 0 0
Selenocysteine synthesis R-HSA-2408557 1.040300e-01 0.983 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.280641e-01 0.893 0 0
Deubiquitination R-HSA-5688426 1.237145e-01 0.908 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.339048e-01 0.873 0 0
Signaling by KIT in disease R-HSA-9669938 1.154475e-01 0.938 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.045747e-01 0.981 0 0
Interleukin-2 signaling R-HSA-9020558 1.180989e-01 0.928 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.236491e-01 0.908 0 0
Signaling by NOTCH3 R-HSA-9012852 1.291594e-01 0.889 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.245514e-01 0.905 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.308888e-01 0.883 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.180989e-01 0.928 0 0
G alpha (z) signalling events R-HSA-418597 1.291594e-01 0.889 0 0
Growth hormone receptor signaling R-HSA-982772 1.245514e-01 0.905 0 0
Signaling by ALK R-HSA-201556 1.308888e-01 0.883 0 0
Signaling by Leptin R-HSA-2586552 1.045747e-01 0.981 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.066083e-01 0.972 0 0
Signaling by FGFR1 R-HSA-5654736 1.353214e-01 0.869 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.353214e-01 0.869 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.548053e-01 0.810 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.548053e-01 0.810 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.548053e-01 0.810 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 1.548053e-01 0.810 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.548053e-01 0.810 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.548053e-01 0.810 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.548053e-01 0.810 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.548053e-01 0.810 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.548053e-01 0.810 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.548053e-01 0.810 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.548053e-01 0.810 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.548053e-01 0.810 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.548053e-01 0.810 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.896118e-01 0.722 0 0
Classical Kir channels R-HSA-1296053 1.896118e-01 0.722 0 0
HCN channels R-HSA-1296061 2.229870e-01 0.652 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.229870e-01 0.652 0 0
Nucleotide catabolism defects R-HSA-9735786 2.229870e-01 0.652 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 2.229870e-01 0.652 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.229870e-01 0.652 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.229870e-01 0.652 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.229870e-01 0.652 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.549895e-01 0.593 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.463067e-01 0.835 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.463067e-01 0.835 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.856758e-01 0.544 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.856758e-01 0.544 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.856758e-01 0.544 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.856758e-01 0.544 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.856758e-01 0.544 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.856758e-01 0.544 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.608819e-01 0.793 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.608819e-01 0.793 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.608819e-01 0.793 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.757054e-01 0.755 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.757054e-01 0.755 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.757054e-01 0.755 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.757054e-01 0.755 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.151000e-01 0.502 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 3.151000e-01 0.502 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 3.151000e-01 0.502 0 0
Erythropoietin activates RAS R-HSA-9027284 1.907321e-01 0.720 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.907321e-01 0.720 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.907321e-01 0.720 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.907321e-01 0.720 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.059203e-01 0.686 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.433139e-01 0.464 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.433139e-01 0.464 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.433139e-01 0.464 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 3.433139e-01 0.464 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.433139e-01 0.464 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.434925e-01 0.843 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.434925e-01 0.843 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.434925e-01 0.843 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.212312e-01 0.655 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.366291e-01 0.626 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.703672e-01 0.431 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.703672e-01 0.431 0 0
phospho-PLA2 pathway R-HSA-111995 3.703672e-01 0.431 0 0
Activation of RAS in B cells R-HSA-1169092 3.703672e-01 0.431 0 0
Formation of annular gap junctions R-HSA-196025 3.703672e-01 0.431 0 0
Telomere Extension By Telomerase R-HSA-171319 1.735091e-01 0.761 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.838820e-01 0.735 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.382991e-01 0.859 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.944137e-01 0.711 0 0
DAP12 signaling R-HSA-2424491 1.944137e-01 0.711 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.944137e-01 0.711 0 0
Gap junction degradation R-HSA-190873 3.963075e-01 0.402 0 0
Downstream signal transduction R-HSA-186763 2.050899e-01 0.688 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.614884e-01 0.792 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.830266e-01 0.548 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.984666e-01 0.525 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.984666e-01 0.525 0 0
Nucleosome assembly R-HSA-774815 1.859714e-01 0.731 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.859714e-01 0.731 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.138525e-01 0.503 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.138525e-01 0.503 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.138525e-01 0.503 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.138525e-01 0.503 0 0
Dual Incision in GG-NER R-HSA-5696400 2.489565e-01 0.604 0 0
FGFR2 alternative splicing R-HSA-6803529 3.291626e-01 0.483 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.291626e-01 0.483 0 0
HSF1 activation R-HSA-3371511 2.713994e-01 0.566 0 0
HSF1-dependent transactivation R-HSA-3371571 2.380538e-01 0.623 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.373377e-01 0.862 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.470548e-01 0.607 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.470548e-01 0.607 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.594776e-01 0.444 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.561286e-01 0.592 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.561286e-01 0.592 0 0
Translation initiation complex formation R-HSA-72649 2.652682e-01 0.576 0 0
Attenuation phase R-HSA-3371568 3.168092e-01 0.499 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.168092e-01 0.499 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.837178e-01 0.547 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.837178e-01 0.547 0 0
Dual incision in TC-NER R-HSA-6782135 3.023498e-01 0.519 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.039407e-01 0.394 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.039407e-01 0.394 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.039407e-01 0.394 0 0
Packaging Of Telomere Ends R-HSA-171306 4.039407e-01 0.394 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.211125e-01 0.493 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.892736e-01 0.410 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.984666e-01 0.525 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.984666e-01 0.525 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.545629e-01 0.811 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.366291e-01 0.626 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.366291e-01 0.626 0 0
Formation of definitive endoderm R-HSA-9823730 2.830266e-01 0.548 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.984666e-01 0.525 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.138525e-01 0.503 0 0
Telomere Maintenance R-HSA-157579 1.735368e-01 0.761 0 0
Neutrophil degranulation R-HSA-6798695 2.159863e-01 0.666 0 0
Extension of Telomeres R-HSA-180786 1.545629e-01 0.811 0 0
DNA Damage Bypass R-HSA-73893 2.202981e-01 0.657 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.893401e-01 0.539 0 0
Nucleotide Excision Repair R-HSA-5696398 3.697588e-01 0.432 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.827039e-01 0.549 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.395974e-01 0.469 0 0
GAB1 signalosome R-HSA-180292 2.520809e-01 0.598 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.837178e-01 0.547 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.520809e-01 0.598 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.681123e-01 0.774 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.735091e-01 0.761 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.838820e-01 0.735 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.944137e-01 0.711 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.489565e-01 0.604 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.291626e-01 0.483 0 0
RNA Polymerase I Transcription R-HSA-73864 1.575214e-01 0.803 0 0
DNA Double Strand Break Response R-HSA-5693606 2.107433e-01 0.676 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.785739e-01 0.748 0 0
Translesion Synthesis by POLH R-HSA-110320 2.675561e-01 0.573 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.594776e-01 0.444 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.268182e-01 0.644 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.675561e-01 0.573 0 0
Myogenesis R-HSA-525793 1.532993e-01 0.814 0 0
Degradation of DVL R-HSA-4641258 2.827039e-01 0.549 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.457873e-01 0.836 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.017417e-01 0.695 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.396566e-01 0.855 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.107433e-01 0.676 0 0
Cyclin D associated events in G1 R-HSA-69231 1.776783e-01 0.750 0 0
G1 Phase R-HSA-69236 1.776783e-01 0.750 0 0
IGF1R signaling cascade R-HSA-2428924 1.889259e-01 0.724 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.754099e-01 0.756 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.654273e-01 0.781 0 0
Signalling to RAS R-HSA-167044 2.984666e-01 0.525 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.460647e-01 0.835 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.054200e-01 0.515 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.378428e-01 0.624 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.202981e-01 0.657 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.202981e-01 0.657 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.549895e-01 0.593 0 0
PTK6 Down-Regulation R-HSA-8849472 2.549895e-01 0.593 0 0
DCC mediated attractive signaling R-HSA-418885 1.907321e-01 0.720 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.059203e-01 0.686 0 0
Killing mechanisms R-HSA-9664420 2.059203e-01 0.686 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.212312e-01 0.655 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.703672e-01 0.431 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.614884e-01 0.792 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.268182e-01 0.644 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.268182e-01 0.644 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.373377e-01 0.862 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.744481e-01 0.427 0 0
Tight junction interactions R-HSA-420029 3.744481e-01 0.427 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.168092e-01 0.499 0 0
Defective pyroptosis R-HSA-9710421 3.623329e-01 0.441 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.965099e-01 0.402 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.644033e-01 0.578 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.961067e-01 0.708 0 0
Neurexins and neuroligins R-HSA-6794361 2.470548e-01 0.607 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.487367e-01 0.604 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.463067e-01 0.835 0 0
PCP/CE pathway R-HSA-4086400 1.575214e-01 0.803 0 0
Homology Directed Repair R-HSA-5693538 1.959207e-01 0.708 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.229870e-01 0.652 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.229870e-01 0.652 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.856758e-01 0.544 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.433139e-01 0.464 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.532993e-01 0.814 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.291325e-01 0.640 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.268182e-01 0.644 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.282051e-01 0.484 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.855063e-01 0.732 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.849432e-01 0.415 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.961805e-01 0.402 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.855063e-01 0.732 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.212312e-01 0.655 0 0
Frs2-mediated activation R-HSA-170968 1.608819e-01 0.793 0 0
HATs acetylate histones R-HSA-3214847 1.846079e-01 0.734 0 0
Prolonged ERK activation events R-HSA-169893 2.059203e-01 0.686 0 0
DAP12 interactions R-HSA-2172127 3.736580e-01 0.428 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.493934e-01 0.457 0 0
Signaling by SCF-KIT R-HSA-1433557 1.695150e-01 0.771 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.548053e-01 0.810 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.229870e-01 0.652 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.463067e-01 0.835 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.856758e-01 0.544 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 3.151000e-01 0.502 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.433139e-01 0.464 0 0
Disinhibition of SNARE formation R-HSA-114516 3.433139e-01 0.464 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.366291e-01 0.626 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.735091e-01 0.761 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.735091e-01 0.761 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.458736e-01 0.836 0 0
Unwinding of DNA R-HSA-176974 3.963075e-01 0.402 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.859714e-01 0.731 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.378428e-01 0.624 0 0
Metabolism of non-coding RNA R-HSA-194441 1.545629e-01 0.811 0 0
snRNP Assembly R-HSA-191859 1.545629e-01 0.811 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.744481e-01 0.427 0 0
G2/M Checkpoints R-HSA-69481 1.487538e-01 0.828 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.892736e-01 0.410 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.058825e-01 0.392 0 0
Aggrephagy R-HSA-9646399 3.168092e-01 0.499 0 0
Smooth Muscle Contraction R-HSA-445355 2.561286e-01 0.592 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.549895e-01 0.593 0 0
Long-term potentiation R-HSA-9620244 1.434925e-01 0.843 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 2.212312e-01 0.655 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.944331e-01 0.711 0 0
MTOR signalling R-HSA-165159 3.509764e-01 0.455 1 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.229569e-01 0.652 0 0
G2/M Transition R-HSA-69275 2.488605e-01 0.604 0 0
Generic Transcription Pathway R-HSA-212436 1.695962e-01 0.771 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.229870e-01 0.652 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.433139e-01 0.464 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.963075e-01 0.402 0 0
Intra-Golgi traffic R-HSA-6811438 1.536056e-01 0.814 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.487367e-01 0.604 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.134929e-01 0.671 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.584312e-01 0.588 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.057594e-01 0.392 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.535135e-01 0.452 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.458736e-01 0.836 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 2.489565e-01 0.604 0 0
mTORC1-mediated signalling R-HSA-166208 3.291626e-01 0.483 1 1
Free fatty acids regulate insulin secretion R-HSA-400451 3.443770e-01 0.463 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.744481e-01 0.427 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 3.417120e-01 0.466 0 0
Leishmania phagocytosis R-HSA-9664417 3.417120e-01 0.466 0 0
Parasite infection R-HSA-9664407 3.417120e-01 0.466 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.037403e-01 0.517 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.162924e-01 0.665 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.395974e-01 0.469 0 0
NGF-stimulated transcription R-HSA-9031628 2.115576e-01 0.675 0 0
NCAM signaling for neurite out-growth R-HSA-375165 3.399561e-01 0.469 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.896118e-01 0.722 0 0
Sensory perception of sour taste R-HSA-9729555 2.229870e-01 0.652 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.856758e-01 0.544 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.433139e-01 0.464 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.963075e-01 0.402 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.943871e-01 0.711 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.023498e-01 0.519 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.039407e-01 0.394 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.211125e-01 0.493 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.305272e-01 0.481 0 0
S Phase R-HSA-69242 2.674776e-01 0.573 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.402392e-01 0.468 0 0
Signaling by NOTCH R-HSA-157118 2.108035e-01 0.676 0 0
MHC class II antigen presentation R-HSA-2132295 3.550026e-01 0.450 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.978725e-01 0.526 0 0
Cardiogenesis R-HSA-9733709 2.268182e-01 0.644 0 0
Netrin-1 signaling R-HSA-373752 3.736580e-01 0.428 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.073622e-01 0.390 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.735091e-01 0.761 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.125599e-01 0.505 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.614884e-01 0.792 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.151000e-01 0.502 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.963075e-01 0.402 0 0
tRNA processing in the nucleus R-HSA-6784531 1.748601e-01 0.757 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.594776e-01 0.444 0 0
Cell-cell junction organization R-HSA-421270 3.544300e-01 0.450 0 0
Host Interactions of HIV factors R-HSA-162909 2.285233e-01 0.641 0 0
Parasitic Infection Pathways R-HSA-9824443 2.048289e-01 0.689 0 0
Leishmania infection R-HSA-9658195 2.048289e-01 0.689 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.892736e-01 0.410 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.916529e-01 0.535 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.916529e-01 0.535 0 0
G alpha (12/13) signalling events R-HSA-416482 2.963492e-01 0.528 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.849432e-01 0.415 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.421484e-01 0.466 0 0
Post NMDA receptor activation events R-HSA-438064 2.200685e-01 0.657 0 0
Reelin signalling pathway R-HSA-8866376 2.549895e-01 0.593 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.549895e-01 0.593 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.856758e-01 0.544 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.856758e-01 0.544 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.608819e-01 0.793 0 0
NADPH regeneration R-HSA-389542 3.151000e-01 0.502 0 0
Netrin mediated repulsion signals R-HSA-418886 3.433139e-01 0.464 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.433139e-01 0.464 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.433139e-01 0.464 0 0
TGFBR3 expression R-HSA-9839394 1.434925e-01 0.843 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.382991e-01 0.859 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.382991e-01 0.859 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.458736e-01 0.836 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.138525e-01 0.503 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.404841e-01 0.852 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 3.054200e-01 0.515 0 0
Leishmania parasite growth and survival R-HSA-9664433 2.916529e-01 0.535 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 2.916529e-01 0.535 0 0
G alpha (s) signalling events R-HSA-418555 4.057594e-01 0.392 0 0
Neuronal System R-HSA-112316 4.034887e-01 0.394 0 0
Regulation of insulin secretion R-HSA-422356 3.109890e-01 0.507 0 0
HDMs demethylate histones R-HSA-3214842 3.744481e-01 0.427 0 0
Ion transport by P-type ATPases R-HSA-936837 3.588332e-01 0.445 0 0
Biosynthesis of maresins R-HSA-9018682 3.443770e-01 0.463 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.924548e-01 0.716 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.463067e-01 0.835 0 0
Signaling by FGFR R-HSA-190236 1.790359e-01 0.747 0 0
Formation of the nephric duct R-HSA-9830364 1.434925e-01 0.843 0 0
Transmission across Chemical Synapses R-HSA-112315 3.721201e-01 0.429 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.856758e-01 0.544 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.856758e-01 0.544 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.433139e-01 0.464 0 0
Synthesis of PG R-HSA-1483148 2.212312e-01 0.655 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.703672e-01 0.431 0 0
Lipophagy R-HSA-9613354 3.963075e-01 0.402 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.963075e-01 0.402 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.963075e-01 0.402 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.963075e-01 0.402 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.943871e-01 0.711 0 0
Ion channel transport R-HSA-983712 3.787760e-01 0.422 0 0
Inositol phosphate metabolism R-HSA-1483249 2.691434e-01 0.570 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.549767e-01 0.450 0 0
Stimuli-sensing channels R-HSA-2672351 3.919676e-01 0.407 0 0
Cardiac conduction R-HSA-5576891 2.806390e-01 0.552 0 0
Integration of energy metabolism R-HSA-163685 1.995815e-01 0.700 0 0
Regulated Necrosis R-HSA-5218859 3.965099e-01 0.402 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.907321e-01 0.720 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.963075e-01 0.402 0 0
Negative regulation of MET activity R-HSA-6807004 2.830266e-01 0.548 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.652682e-01 0.576 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.744481e-01 0.427 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.492228e-01 0.603 0 0
Sensory processing of sound R-HSA-9659379 3.044382e-01 0.517 0 0
Selenoamino acid metabolism R-HSA-2408522 2.402926e-01 0.619 0 0
LDL clearance R-HSA-8964038 3.291626e-01 0.483 0 0
Glucose metabolism R-HSA-70326 1.906835e-01 0.720 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.509764e-01 0.455 0 0
Depyrimidination R-HSA-73928 3.509764e-01 0.455 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.856758e-01 0.544 0 0
TRP channels R-HSA-3295583 1.532993e-01 0.814 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.489565e-01 0.604 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.181904e-01 0.661 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.892736e-01 0.410 0 0
Cellular response to starvation R-HSA-9711097 2.112050e-01 0.675 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.493934e-01 0.457 0 0
FOXO-mediated transcription R-HSA-9614085 3.182662e-01 0.497 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.520809e-01 0.598 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 3.509764e-01 0.455 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.009543e-01 0.521 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.433139e-01 0.464 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.520809e-01 0.598 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.963075e-01 0.402 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.833161e-01 0.737 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.315716e-01 0.635 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 1.608819e-01 0.793 0 0
FLT3 Signaling R-HSA-9607240 3.282051e-01 0.484 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 2.366291e-01 0.626 0 0
Signaling by Interleukins R-HSA-449147 1.951270e-01 0.710 0 0
Signaling by TGFBR3 R-HSA-9839373 3.961805e-01 0.402 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 1.757054e-01 0.755 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.892736e-01 0.410 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 2.675561e-01 0.573 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.134632e-01 0.671 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.022762e-01 0.520 0 0
IRE1alpha activates chaperones R-HSA-381070 2.540476e-01 0.595 0 0
Interleukin-7 signaling R-HSA-1266695 3.744481e-01 0.427 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.111099e-01 0.386 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.152267e-01 0.382 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.152267e-01 0.382 0 0
Reproduction R-HSA-1474165 4.159694e-01 0.381 0 0
Adherens junctions interactions R-HSA-418990 4.177094e-01 0.379 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.184372e-01 0.378 0 0
HIV elongation arrest and recovery R-HSA-167287 4.184372e-01 0.378 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.184372e-01 0.378 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.184811e-01 0.378 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.211807e-01 0.376 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.211807e-01 0.376 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.211807e-01 0.376 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.211807e-01 0.376 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.211807e-01 0.376 0 0
Pexophagy R-HSA-9664873 4.211807e-01 0.376 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.211807e-01 0.376 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.245380e-01 0.372 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.245380e-01 0.372 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.295022e-01 0.367 0 0
Gap junction trafficking and regulation R-HSA-157858 4.295303e-01 0.367 0 0
Signaling by Erythropoietin R-HSA-9006335 4.327523e-01 0.364 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.327523e-01 0.364 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.327523e-01 0.364 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.338119e-01 0.363 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.362550e-01 0.360 0 0
Azathioprine ADME R-HSA-9748787 4.405034e-01 0.356 0 0
PPARA activates gene expression R-HSA-1989781 4.421469e-01 0.354 0 0
Ca2+ pathway R-HSA-4086398 4.430441e-01 0.354 0 0
Vesicle-mediated transport R-HSA-5653656 4.450186e-01 0.352 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.450304e-01 0.352 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.450304e-01 0.352 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.450304e-01 0.352 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.450304e-01 0.352 0 0
Prostanoid ligand receptors R-HSA-391908 4.450304e-01 0.352 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.450304e-01 0.352 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.468765e-01 0.350 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.468765e-01 0.350 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.468765e-01 0.350 0 0
Interleukin-37 signaling R-HSA-9008059 4.468765e-01 0.350 0 0
Meiotic recombination R-HSA-912446 4.513943e-01 0.345 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.513943e-01 0.345 0 0
Signaling by ERBB4 R-HSA-1236394 4.522307e-01 0.345 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.546588e-01 0.342 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.608011e-01 0.336 0 0
EGFR downregulation R-HSA-182971 4.608011e-01 0.336 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.613675e-01 0.336 0 0
Protein ubiquitination R-HSA-8852135 4.613675e-01 0.336 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.621972e-01 0.335 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.630498e-01 0.334 0 0
HIV Infection R-HSA-162906 4.652969e-01 0.332 0 0
Signaling by WNT R-HSA-195721 4.678887e-01 0.330 0 0
DS-GAG biosynthesis R-HSA-2022923 4.678989e-01 0.330 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.678989e-01 0.330 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.678989e-01 0.330 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.678989e-01 0.330 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 4.678989e-01 0.330 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.678989e-01 0.330 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.678989e-01 0.330 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.678989e-01 0.330 0 0
Activation of RAC1 R-HSA-428540 4.678989e-01 0.330 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.679229e-01 0.330 0 0
UCH proteinases R-HSA-5689603 4.704509e-01 0.327 0 0
Signaling by NOTCH1 R-HSA-1980143 4.704509e-01 0.327 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.729068e-01 0.325 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.729068e-01 0.325 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.745186e-01 0.324 0 0
Signaling by WNT in cancer R-HSA-4791275 4.745186e-01 0.324 0 0
DNA strand elongation R-HSA-69190 4.745186e-01 0.324 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.745186e-01 0.324 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.759133e-01 0.322 0 0
PTEN Regulation R-HSA-6807070 4.830982e-01 0.316 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.830982e-01 0.316 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.835181e-01 0.316 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.849579e-01 0.314 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.871238e-01 0.312 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.880225e-01 0.312 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.880225e-01 0.312 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.880225e-01 0.312 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.898263e-01 0.310 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.898263e-01 0.310 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.898263e-01 0.310 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.898263e-01 0.310 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.898263e-01 0.310 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.898263e-01 0.310 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.898263e-01 0.310 0 0
Leading Strand Synthesis R-HSA-69109 4.898263e-01 0.310 0 0
Polymerase switching R-HSA-69091 4.898263e-01 0.310 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.898263e-01 0.310 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.898263e-01 0.310 0 0
MET activates RAS signaling R-HSA-8851805 4.898263e-01 0.310 0 0
Interleukin-15 signaling R-HSA-8983432 4.898263e-01 0.310 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.898263e-01 0.310 0 0
Regulation of IFNG signaling R-HSA-877312 4.898263e-01 0.310 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.898263e-01 0.310 0 0
Disorders of Nervous System Development R-HSA-9697154 4.898263e-01 0.310 0 0
Pervasive developmental disorders R-HSA-9005895 4.898263e-01 0.310 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 4.898263e-01 0.310 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.898263e-01 0.310 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 4.898263e-01 0.310 0 0
HDACs deacetylate histones R-HSA-3214815 4.940263e-01 0.306 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.940263e-01 0.306 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.973455e-01 0.303 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.013070e-01 0.300 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.013070e-01 0.300 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.013070e-01 0.300 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.013070e-01 0.300 0 0
Ion homeostasis R-HSA-5578775 5.044271e-01 0.297 0 0
NRAGE signals death through JNK R-HSA-193648 5.044271e-01 0.297 0 0
TNF signaling R-HSA-75893 5.044271e-01 0.297 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.093853e-01 0.293 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.093853e-01 0.293 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.108515e-01 0.292 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.108515e-01 0.292 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.108515e-01 0.292 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.108515e-01 0.292 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.108515e-01 0.292 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.108515e-01 0.292 0 0
Formation of axial mesoderm R-HSA-9796292 5.108515e-01 0.292 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.108515e-01 0.292 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.108515e-01 0.292 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.143674e-01 0.289 0 0
Signaling by NOTCH2 R-HSA-1980145 5.143674e-01 0.289 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.143674e-01 0.289 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.147165e-01 0.288 0 0
Dectin-2 family R-HSA-5621480 5.147165e-01 0.288 0 0
Synthesis of PA R-HSA-1483166 5.147165e-01 0.288 0 0
Formation of the cornified envelope R-HSA-6809371 5.225508e-01 0.282 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.248907e-01 0.280 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 5.248907e-01 0.280 0 0
Regulation of Apoptosis R-HSA-169911 5.271995e-01 0.278 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.271995e-01 0.278 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.271995e-01 0.278 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.271995e-01 0.278 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.310113e-01 0.275 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.310113e-01 0.275 0 0
Hydrolysis of LPC R-HSA-1483115 5.310113e-01 0.275 0 0
HDL assembly R-HSA-8963896 5.310113e-01 0.275 0 0
Signal regulatory protein family interactions R-HSA-391160 5.310113e-01 0.275 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.310113e-01 0.275 0 0
Zinc transporters R-HSA-435354 5.310113e-01 0.275 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.349464e-01 0.272 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.398000e-01 0.268 0 0
GPVI-mediated activation cascade R-HSA-114604 5.398000e-01 0.268 0 0
tRNA processing R-HSA-72306 5.402490e-01 0.267 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.407971e-01 0.267 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.407971e-01 0.267 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.407971e-01 0.267 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.448803e-01 0.264 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.448803e-01 0.264 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.448803e-01 0.264 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.448803e-01 0.264 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.448803e-01 0.264 0 0
SARS-CoV Infections R-HSA-9679506 5.463899e-01 0.262 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.479059e-01 0.261 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.492569e-01 0.260 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.503415e-01 0.259 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.503415e-01 0.259 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.503415e-01 0.259 0 0
Translesion synthesis by REV1 R-HSA-110312 5.503415e-01 0.259 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.503415e-01 0.259 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.503415e-01 0.259 0 0
Transport and metabolism of PAPS R-HSA-174362 5.503415e-01 0.259 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.503415e-01 0.259 0 0
p38MAPK events R-HSA-171007 5.503415e-01 0.259 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.503415e-01 0.259 0 0
Signaling by Activin R-HSA-1502540 5.503415e-01 0.259 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.503415e-01 0.259 0 0
Protein methylation R-HSA-8876725 5.503415e-01 0.259 0 0
HCMV Early Events R-HSA-9609690 5.503913e-01 0.259 0 0
Cleavage of the damaged purine R-HSA-110331 5.521662e-01 0.258 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.521662e-01 0.258 0 0
Metabolism of folate and pterines R-HSA-196757 5.521662e-01 0.258 0 0
PLC beta mediated events R-HSA-112043 5.546897e-01 0.256 0 0
Potential therapeutics for SARS R-HSA-9679191 5.604614e-01 0.251 0 0
Gene Silencing by RNA R-HSA-211000 5.606821e-01 0.251 0 0
Purine salvage R-HSA-74217 5.642960e-01 0.248 0 0
Depurination R-HSA-73927 5.642960e-01 0.248 0 0
Signaling by PDGF R-HSA-186797 5.643719e-01 0.248 0 0
Heme signaling R-HSA-9707616 5.643719e-01 0.248 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.643719e-01 0.248 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.680506e-01 0.246 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.688761e-01 0.245 0 0
Translesion synthesis by POLI R-HSA-5656121 5.688761e-01 0.245 0 0
Phosphorylation of the APC/C R-HSA-176412 5.688761e-01 0.245 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 5.688761e-01 0.245 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 5.688761e-01 0.245 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 5.688761e-01 0.245 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.688761e-01 0.245 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.688761e-01 0.245 0 0
Activation of the phototransduction cascade R-HSA-2485179 5.688761e-01 0.245 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.688761e-01 0.245 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.688761e-01 0.245 0 0
Atorvastatin ADME R-HSA-9754706 5.688761e-01 0.245 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 5.688761e-01 0.245 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.688761e-01 0.245 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.688761e-01 0.245 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.688761e-01 0.245 0 0
Negative regulation of FLT3 R-HSA-9706369 5.688761e-01 0.245 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.695694e-01 0.244 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.739246e-01 0.241 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.739246e-01 0.241 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.761879e-01 0.239 0 0
Insulin receptor signalling cascade R-HSA-74751 5.833457e-01 0.234 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.866478e-01 0.232 0 0
Translesion synthesis by POLK R-HSA-5655862 5.866478e-01 0.232 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 5.866478e-01 0.232 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 5.866478e-01 0.232 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.866478e-01 0.232 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.866478e-01 0.232 0 0
Scavenging by Class B Receptors R-HSA-3000471 5.866478e-01 0.232 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.866478e-01 0.232 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.866478e-01 0.232 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.866478e-01 0.232 0 0
Passive transport by Aquaporins R-HSA-432047 5.866478e-01 0.232 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.866478e-01 0.232 0 0
Disorders of Developmental Biology R-HSA-9675151 5.866478e-01 0.232 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.878408e-01 0.231 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.878408e-01 0.231 0 0
Interleukin-2 family signaling R-HSA-451927 5.878408e-01 0.231 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.878408e-01 0.231 0 0
Diseases of Immune System R-HSA-5260271 5.878408e-01 0.231 0 0
Glycogen metabolism R-HSA-8982491 5.878408e-01 0.231 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.878408e-01 0.231 0 0
ER-Phagosome pathway R-HSA-1236974 5.902823e-01 0.229 0 0
Base Excision Repair R-HSA-73884 5.982200e-01 0.223 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.992543e-01 0.222 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.992543e-01 0.222 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.992543e-01 0.222 0 0
AURKA Activation by TPX2 R-HSA-8854518 6.017860e-01 0.221 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 6.017860e-01 0.221 0 0
HIV Life Cycle R-HSA-162587 6.031082e-01 0.220 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.036879e-01 0.219 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 6.036879e-01 0.219 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.036879e-01 0.219 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.036879e-01 0.219 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.036879e-01 0.219 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.036879e-01 0.219 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.036879e-01 0.219 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 6.036879e-01 0.219 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.039066e-01 0.219 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.090229e-01 0.215 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.104283e-01 0.214 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.104283e-01 0.214 0 0
Kidney development R-HSA-9830369 6.108022e-01 0.214 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.146477e-01 0.211 0 0
Transcription of the HIV genome R-HSA-167172 6.196808e-01 0.208 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.200265e-01 0.208 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.200265e-01 0.208 0 0
Polo-like kinase mediated events R-HSA-156711 6.200265e-01 0.208 0 0
Mismatch Repair R-HSA-5358508 6.200265e-01 0.208 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.200265e-01 0.208 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.200265e-01 0.208 0 0
PKA activation in glucagon signalling R-HSA-164378 6.200265e-01 0.208 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.200265e-01 0.208 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.200265e-01 0.208 0 0
PKA activation R-HSA-163615 6.200265e-01 0.208 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.200265e-01 0.208 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 6.200265e-01 0.208 0 0
Platelet sensitization by LDL R-HSA-432142 6.200265e-01 0.208 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.200265e-01 0.208 0 0
Tie2 Signaling R-HSA-210993 6.200265e-01 0.208 0 0
Apoptotic factor-mediated response R-HSA-111471 6.200265e-01 0.208 0 0
Signaling by TGFB family members R-HSA-9006936 6.207107e-01 0.207 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.213631e-01 0.207 0 0
Ca-dependent events R-HSA-111996 6.213631e-01 0.207 0 0
Signaling by Insulin receptor R-HSA-74752 6.214719e-01 0.207 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.220667e-01 0.206 0 0
FCGR activation R-HSA-2029481 6.290315e-01 0.201 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.290315e-01 0.201 0 0
TBC/RABGAPs R-HSA-8854214 6.320595e-01 0.199 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.320595e-01 0.199 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.320595e-01 0.199 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.356926e-01 0.197 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.356926e-01 0.197 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.356926e-01 0.197 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.356926e-01 0.197 0 0
Specification of the neural plate border R-HSA-9834899 6.356926e-01 0.197 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.356926e-01 0.197 0 0
The NLRP3 inflammasome R-HSA-844456 6.356926e-01 0.197 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.356926e-01 0.197 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.356926e-01 0.197 0 0
Other interleukin signaling R-HSA-449836 6.356926e-01 0.197 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.370212e-01 0.196 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.370212e-01 0.196 0 0
RMTs methylate histone arginines R-HSA-3214858 6.425186e-01 0.192 0 0
Amine ligand-binding receptors R-HSA-375280 6.425186e-01 0.192 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.438584e-01 0.191 0 0
Rab regulation of trafficking R-HSA-9007101 6.446045e-01 0.191 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.454816e-01 0.190 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.507136e-01 0.187 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.507136e-01 0.187 0 0
Signaling by NODAL R-HSA-1181150 6.507136e-01 0.187 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.507136e-01 0.187 0 0
Protein hydroxylation R-HSA-9629569 6.507136e-01 0.187 0 0
Signal transduction by L1 R-HSA-445144 6.507136e-01 0.187 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.507136e-01 0.187 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.524837e-01 0.185 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 6.527416e-01 0.185 0 0
Somitogenesis R-HSA-9824272 6.527416e-01 0.185 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.527416e-01 0.185 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.527416e-01 0.185 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.527416e-01 0.185 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.538016e-01 0.185 0 0
Toll-like Receptor Cascades R-HSA-168898 6.571337e-01 0.182 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.575734e-01 0.182 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.575734e-01 0.182 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.582906e-01 0.182 0 0
Potassium Channels R-HSA-1296071 6.582906e-01 0.182 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.582906e-01 0.182 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.619808e-01 0.179 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.619808e-01 0.179 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.619808e-01 0.179 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.619808e-01 0.179 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.627304e-01 0.179 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.627304e-01 0.179 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.627304e-01 0.179 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.627304e-01 0.179 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.627304e-01 0.179 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.651162e-01 0.177 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.651162e-01 0.177 0 0
Lagging Strand Synthesis R-HSA-69186 6.651162e-01 0.177 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.651162e-01 0.177 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.651162e-01 0.177 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.651162e-01 0.177 0 0
Basigin interactions R-HSA-210991 6.651162e-01 0.177 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.651162e-01 0.177 0 0
Signaling by NOTCH4 R-HSA-9013694 6.700191e-01 0.174 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.723234e-01 0.172 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.723234e-01 0.172 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.723234e-01 0.172 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.724868e-01 0.172 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.764486e-01 0.170 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.764486e-01 0.170 0 0
Centrosome maturation R-HSA-380287 6.779165e-01 0.169 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.779165e-01 0.169 0 0
CS-GAG biosynthesis R-HSA-2022870 6.789257e-01 0.168 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.789257e-01 0.168 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.789257e-01 0.168 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.789257e-01 0.168 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.789257e-01 0.168 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.789257e-01 0.168 0 0
Ribavirin ADME R-HSA-9755088 6.789257e-01 0.168 0 0
Gluconeogenesis R-HSA-70263 6.820129e-01 0.166 0 0
Hedgehog 'off' state R-HSA-5610787 6.859536e-01 0.164 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.869392e-01 0.163 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.913113e-01 0.160 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.921666e-01 0.160 0 0
Free fatty acid receptors R-HSA-444209 6.921666e-01 0.160 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.921666e-01 0.160 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 6.921666e-01 0.160 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.921666e-01 0.160 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.921666e-01 0.160 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.924583e-01 0.160 0 0
Interleukin-1 signaling R-HSA-9020702 6.926171e-01 0.160 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.932897e-01 0.159 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.991795e-01 0.155 0 0
PI Metabolism R-HSA-1483255 6.991795e-01 0.155 0 0
PI3K Cascade R-HSA-109704 7.003844e-01 0.155 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.048622e-01 0.152 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.048622e-01 0.152 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.048622e-01 0.152 0 0
Carnitine shuttle R-HSA-200425 7.048622e-01 0.152 0 0
Formation of the ureteric bud R-HSA-9830674 7.048622e-01 0.152 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.048622e-01 0.152 0 0
Syndecan interactions R-HSA-3000170 7.048622e-01 0.152 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.063391e-01 0.151 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.092351e-01 0.149 0 0
The phototransduction cascade R-HSA-2514856 7.092351e-01 0.149 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.138852e-01 0.146 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.153014e-01 0.146 0 0
PKR-mediated signaling R-HSA-9833482 7.153014e-01 0.146 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.154223e-01 0.145 0 0
G alpha (i) signalling events R-HSA-418594 7.160460e-01 0.145 0 0
CYP2E1 reactions R-HSA-211999 7.170350e-01 0.144 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.170350e-01 0.144 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.170350e-01 0.144 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.178661e-01 0.144 0 0
Orc1 removal from chromatin R-HSA-68949 7.178661e-01 0.144 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.178661e-01 0.144 0 0
Interleukin-1 family signaling R-HSA-446652 7.190787e-01 0.143 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.244182e-01 0.140 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.262807e-01 0.139 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.262807e-01 0.139 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.287064e-01 0.137 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.287064e-01 0.137 0 0
G protein gated Potassium channels R-HSA-1296059 7.287064e-01 0.137 0 0
Laminin interactions R-HSA-3000157 7.287064e-01 0.137 0 0
Death Receptor Signaling R-HSA-73887 7.292689e-01 0.137 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.344819e-01 0.134 0 0
Synthesis of DNA R-HSA-69239 7.364335e-01 0.133 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.398971e-01 0.131 0 0
MET activates PTK2 signaling R-HSA-8874081 7.398971e-01 0.131 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.398971e-01 0.131 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.398971e-01 0.131 0 0
Metalloprotease DUBs R-HSA-5689901 7.398971e-01 0.131 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.398971e-01 0.131 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.398971e-01 0.131 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.398971e-01 0.131 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.422913e-01 0.129 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.424730e-01 0.129 0 0
Paracetamol ADME R-HSA-9753281 7.424730e-01 0.129 0 0
Circadian clock R-HSA-9909396 7.448563e-01 0.128 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.480497e-01 0.126 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.480497e-01 0.126 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.500422e-01 0.125 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.502574e-01 0.125 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.502574e-01 0.125 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.506268e-01 0.125 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.506268e-01 0.125 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.506268e-01 0.125 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.506268e-01 0.125 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.506268e-01 0.125 0 0
Signaling by BMP R-HSA-201451 7.506268e-01 0.125 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.506268e-01 0.125 0 0
Triglyceride biosynthesis R-HSA-75109 7.506268e-01 0.125 0 0
Synthesis of PE R-HSA-1483213 7.506268e-01 0.125 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.506268e-01 0.125 0 0
TCR signaling R-HSA-202403 7.537093e-01 0.123 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.537093e-01 0.123 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.537093e-01 0.123 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.556260e-01 0.122 0 0
IRS-mediated signalling R-HSA-112399 7.578386e-01 0.120 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.609146e-01 0.119 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.609146e-01 0.119 0 0
Insulin receptor recycling R-HSA-77387 7.609146e-01 0.119 0 0
Inflammasomes R-HSA-622312 7.609146e-01 0.119 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.609146e-01 0.119 0 0
Prednisone ADME R-HSA-9757110 7.609146e-01 0.119 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.647341e-01 0.116 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.680023e-01 0.115 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.701006e-01 0.113 0 0
DNA methylation R-HSA-5334118 7.707785e-01 0.113 0 0
Late endosomal microautophagy R-HSA-9615710 7.707785e-01 0.113 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.707785e-01 0.113 0 0
DARPP-32 events R-HSA-180024 7.707785e-01 0.113 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.739965e-01 0.111 0 0
Hemostasis R-HSA-109582 7.749485e-01 0.111 0 0
Kinesins R-HSA-983189 7.793978e-01 0.108 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.793978e-01 0.108 0 0
Glutathione conjugation R-HSA-156590 7.793978e-01 0.108 0 0
Activation of the pre-replicative complex R-HSA-68962 7.802360e-01 0.108 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.802360e-01 0.108 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.802360e-01 0.108 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.802360e-01 0.108 0 0
Activation of BH3-only proteins R-HSA-114452 7.802360e-01 0.108 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.856040e-01 0.105 0 0
Downstream TCR signaling R-HSA-202424 7.856040e-01 0.105 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.856249e-01 0.105 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.862016e-01 0.104 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.862016e-01 0.104 0 0
Aquaporin-mediated transport R-HSA-445717 7.862016e-01 0.104 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.862016e-01 0.104 0 0
Nucleotide salvage R-HSA-8956321 7.862016e-01 0.104 0 0
Collagen degradation R-HSA-1442490 7.862016e-01 0.104 0 0
Cargo concentration in the ER R-HSA-5694530 7.893039e-01 0.103 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.893039e-01 0.103 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.893039e-01 0.103 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.893039e-01 0.103 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.928200e-01 0.101 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.928200e-01 0.101 0 0
Neddylation R-HSA-8951664 7.934843e-01 0.100 0 0
G0 and Early G1 R-HSA-1538133 7.979982e-01 0.098 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.979982e-01 0.098 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.979982e-01 0.098 0 0
HS-GAG degradation R-HSA-2024096 7.979982e-01 0.098 0 0
HCMV Infection R-HSA-9609646 7.999963e-01 0.097 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.020861e-01 0.096 0 0
Protein folding R-HSA-391251 8.020861e-01 0.096 0 0
Xenobiotics R-HSA-211981 8.055161e-01 0.094 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.055161e-01 0.094 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.063342e-01 0.093 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.063342e-01 0.093 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.063342e-01 0.093 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.063342e-01 0.093 0 0
G-protein beta:gamma signalling R-HSA-397795 8.063342e-01 0.093 0 0
Nuclear RNA decay R-HSA-9930044 8.063342e-01 0.093 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.073388e-01 0.093 0 0
Cellular response to hypoxia R-HSA-1234174 8.116010e-01 0.091 0 0
Collagen formation R-HSA-1474290 8.124735e-01 0.090 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.143267e-01 0.089 0 0
CS/DS degradation R-HSA-2024101 8.143267e-01 0.089 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.143267e-01 0.089 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.143267e-01 0.089 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.143267e-01 0.089 0 0
Heme degradation R-HSA-189483 8.143267e-01 0.089 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.143267e-01 0.089 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.175155e-01 0.088 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.185980e-01 0.087 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.195589e-01 0.086 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 8.219898e-01 0.085 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.219898e-01 0.085 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.219898e-01 0.085 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.219898e-01 0.085 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.219898e-01 0.085 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 8.271872e-01 0.082 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.288480e-01 0.082 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.293370e-01 0.081 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.293370e-01 0.081 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.293370e-01 0.081 0 0
PERK regulates gene expression R-HSA-381042 8.293370e-01 0.081 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.293370e-01 0.081 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.363815e-01 0.078 0 0
RNA Polymerase III Transcription R-HSA-74158 8.363815e-01 0.078 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.363815e-01 0.078 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.363815e-01 0.078 0 0
FLT3 signaling in disease R-HSA-9682385 8.363815e-01 0.078 0 0
G1/S-Specific Transcription R-HSA-69205 8.363815e-01 0.078 0 0
Calmodulin induced events R-HSA-111933 8.363815e-01 0.078 0 0
CaM pathway R-HSA-111997 8.363815e-01 0.078 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.364384e-01 0.078 0 0
G1/S Transition R-HSA-69206 8.395044e-01 0.076 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.395428e-01 0.076 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.395428e-01 0.076 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.395428e-01 0.076 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.409019e-01 0.075 0 0
Voltage gated Potassium channels R-HSA-1296072 8.431356e-01 0.074 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.431356e-01 0.074 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.431356e-01 0.074 0 0
Degradation of AXIN R-HSA-4641257 8.431356e-01 0.074 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.431356e-01 0.074 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.431356e-01 0.074 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.431356e-01 0.074 0 0
Collagen chain trimerization R-HSA-8948216 8.431356e-01 0.074 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 8.446602e-01 0.073 0 0
Hedgehog 'on' state R-HSA-5632684 8.446602e-01 0.073 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.446602e-01 0.073 0 0
DNA Replication R-HSA-69306 8.450032e-01 0.073 0 0
Platelet degranulation R-HSA-114608 8.472832e-01 0.072 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.496113e-01 0.071 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.496113e-01 0.071 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.496113e-01 0.071 0 0
Cellular response to chemical stress R-HSA-9711123 8.542612e-01 0.068 0 0
Aspirin ADME R-HSA-9749641 8.544528e-01 0.068 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.558200e-01 0.068 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 8.558200e-01 0.068 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.558200e-01 0.068 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.558200e-01 0.068 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.558200e-01 0.068 0 0
HCMV Late Events R-HSA-9610379 8.586087e-01 0.066 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.617728e-01 0.065 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.617728e-01 0.065 0 0
HIV Transcription Elongation R-HSA-167169 8.617728e-01 0.065 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.617728e-01 0.065 0 0
Generation of second messenger molecules R-HSA-202433 8.617728e-01 0.065 0 0
Interferon gamma signaling R-HSA-877300 8.650287e-01 0.063 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.655264e-01 0.063 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.655264e-01 0.063 0 0
Interferon Signaling R-HSA-913531 8.674039e-01 0.062 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.674801e-01 0.062 0 0
Aflatoxin activation and detoxification R-HSA-5423646 8.674801e-01 0.062 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.674801e-01 0.062 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.674801e-01 0.062 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.674801e-01 0.062 0 0
Maturation of spike protein R-HSA-9694548 8.674801e-01 0.062 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.674801e-01 0.062 0 0
HIV Transcription Initiation R-HSA-167161 8.729522e-01 0.059 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.729522e-01 0.059 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.729522e-01 0.059 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.729522e-01 0.059 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.729522e-01 0.059 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.729522e-01 0.059 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.729522e-01 0.059 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.729522e-01 0.059 0 0
Cholesterol biosynthesis R-HSA-191273 8.765168e-01 0.057 0 0
Disease R-HSA-1643685 8.770125e-01 0.057 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.781986e-01 0.056 0 0
Viral Infection Pathways R-HSA-9824446 8.786792e-01 0.056 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.832286e-01 0.054 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.832286e-01 0.054 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.875412e-01 0.052 0 0
Gap junction trafficking R-HSA-190828 8.880512e-01 0.052 0 0
Surfactant metabolism R-HSA-5683826 8.880512e-01 0.052 0 0
Proteasome assembly R-HSA-9907900 8.880512e-01 0.052 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.880512e-01 0.052 0 0
Amyloid fiber formation R-HSA-977225 8.882316e-01 0.051 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.882316e-01 0.051 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 8.882316e-01 0.051 0 0
SLC transporter disorders R-HSA-5619102 8.883060e-01 0.051 0 0
Signaling by Hedgehog R-HSA-5358351 8.904366e-01 0.050 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.919019e-01 0.050 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.926750e-01 0.049 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.926750e-01 0.049 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.926750e-01 0.049 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.926750e-01 0.049 0 0
DAG and IP3 signaling R-HSA-1489509 8.926750e-01 0.049 0 0
GPCR downstream signalling R-HSA-388396 8.933444e-01 0.049 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.954601e-01 0.048 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.971080e-01 0.047 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.971080e-01 0.047 0 0
Sphingolipid metabolism R-HSA-428157 9.002056e-01 0.046 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.013582e-01 0.045 0 0
Synthesis of PC R-HSA-1483191 9.013582e-01 0.045 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.013582e-01 0.045 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.020707e-01 0.045 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.024568e-01 0.045 0 0
Innate Immune System R-HSA-168249 9.028280e-01 0.044 0 0
Intraflagellar transport R-HSA-5620924 9.054330e-01 0.043 0 0
Metal ion SLC transporters R-HSA-425410 9.054330e-01 0.043 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.054911e-01 0.043 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.076625e-01 0.042 0 0
Interferon alpha/beta signaling R-HSA-909733 9.076625e-01 0.042 0 0
G alpha (q) signalling events R-HSA-416476 9.097938e-01 0.041 0 0
Mitochondrial biogenesis R-HSA-1592230 9.129636e-01 0.040 0 0
Peptide hormone metabolism R-HSA-2980736 9.129636e-01 0.040 0 0
Phospholipid metabolism R-HSA-1483257 9.129940e-01 0.040 0 0
Keratinization R-HSA-6805567 9.130689e-01 0.039 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.166765e-01 0.038 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.201194e-01 0.036 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.201194e-01 0.036 0 0
Nucleotide biosynthesis R-HSA-8956320 9.234203e-01 0.035 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.266379e-01 0.033 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.296190e-01 0.032 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.325278e-01 0.030 0 0
Drug ADME R-HSA-9748784 9.345360e-01 0.029 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.379903e-01 0.028 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.405536e-01 0.027 0 0
Peroxisomal protein import R-HSA-9033241 9.405536e-01 0.027 0 0
Triglyceride metabolism R-HSA-8979227 9.405536e-01 0.027 0 0
tRNA Aminoacylation R-HSA-379724 9.430111e-01 0.025 0 0
Metabolism of polyamines R-HSA-351202 9.430111e-01 0.025 0 0
MAP kinase activation R-HSA-450294 9.453672e-01 0.024 0 0
Sensory perception of taste R-HSA-9717189 9.463572e-01 0.024 0 0
ABC-family proteins mediated transport R-HSA-382556 9.472666e-01 0.024 0 0
Mitochondrial protein import R-HSA-1268020 9.476260e-01 0.023 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.476260e-01 0.023 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.479869e-01 0.023 0 0
Signaling by GPCR R-HSA-372790 9.493485e-01 0.023 0 0
Adaptive Immune System R-HSA-1280218 9.495704e-01 0.022 0 0
Complex I biogenesis R-HSA-6799198 9.497915e-01 0.022 0 0
RSV-host interactions R-HSA-9833110 9.557314e-01 0.020 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.563191e-01 0.019 0 0
Infectious disease R-HSA-5663205 9.566893e-01 0.019 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.593075e-01 0.018 0 0
O-linked glycosylation of mucins R-HSA-913709 9.593495e-01 0.018 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.593495e-01 0.018 0 0
COPII-mediated vesicle transport R-HSA-204005 9.626429e-01 0.017 0 0
Interleukin-17 signaling R-HSA-448424 9.626429e-01 0.017 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.632684e-01 0.016 0 0
Metabolism of porphyrins R-HSA-189445 9.641883e-01 0.016 0 0
Metabolism of cofactors R-HSA-8978934 9.641883e-01 0.016 0 0
Purine catabolism R-HSA-74259 9.656698e-01 0.015 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.664560e-01 0.015 0 0
Immune System R-HSA-168256 9.676346e-01 0.014 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.682474e-01 0.014 0 0
Signaling by FGFR in disease R-HSA-1226099 9.684518e-01 0.014 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.684518e-01 0.014 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.697572e-01 0.013 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.697572e-01 0.013 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.710662e-01 0.013 0 0
Diseases of glycosylation R-HSA-3781865 9.713099e-01 0.013 0 0
Gastrulation R-HSA-9758941 9.714010e-01 0.013 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.720824e-01 0.012 0 0
Translation of Structural Proteins R-HSA-9694635 9.722084e-01 0.012 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.723034e-01 0.012 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.733586e-01 0.012 0 0
ABC transporter disorders R-HSA-5619084 9.733586e-01 0.012 0 0
Protein localization R-HSA-9609507 9.748517e-01 0.011 0 0
Cilium Assembly R-HSA-5617833 9.759848e-01 0.011 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.774934e-01 0.010 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.784345e-01 0.009 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.790603e-01 0.009 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.793273e-01 0.009 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.817904e-01 0.008 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.817904e-01 0.008 0 0
Translation R-HSA-72766 9.821084e-01 0.008 0 0
Co-inhibition by PD-1 R-HSA-389948 9.822222e-01 0.008 0 0
Pyruvate metabolism R-HSA-70268 9.825444e-01 0.008 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.832673e-01 0.007 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.833999e-01 0.007 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.864573e-01 0.006 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.880996e-01 0.005 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.884287e-01 0.005 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.887619e-01 0.005 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.912957e-01 0.004 0 0
Peptide ligand-binding receptors R-HSA-375276 9.918306e-01 0.004 0 0
Visual phototransduction R-HSA-2187338 9.924948e-01 0.003 0 0
Platelet homeostasis R-HSA-418346 9.931205e-01 0.003 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.935585e-01 0.003 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.956184e-01 0.002 0 0
Metabolism of steroids R-HSA-8957322 9.962314e-01 0.002 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.962319e-01 0.002 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.964482e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.972329e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.977147e-01 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.982790e-01 0.001 0 0
O-linked glycosylation R-HSA-5173105 9.985050e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.986085e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.990594e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.991750e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.992422e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.995102e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.996433e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.996936e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.996954e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.997596e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.997938e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998236e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.998564e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999275e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999623e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999634e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999705e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999851e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999946e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999966e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999980e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999988e-01 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 2.220446e-16 15.654 0 0
HSF1-dependent transactivation R-HSA-3371571 8.104628e-15 14.091 0 0
Axon guidance R-HSA-422475 7.438494e-15 14.129 0 0
M Phase R-HSA-68886 9.658940e-15 14.015 0 0
Nervous system development R-HSA-9675108 1.743050e-14 13.759 0 0
Cell Cycle R-HSA-1640170 1.042277e-12 11.982 0 0
Cell Cycle, Mitotic R-HSA-69278 3.002709e-12 11.522 0 0
Attenuation phase R-HSA-3371568 8.823831e-12 11.054 0 0
Metabolism of RNA R-HSA-8953854 1.065503e-11 10.972 0 0
HSF1 activation R-HSA-3371511 2.048062e-11 10.689 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.962419e-11 10.707 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.201583e-11 10.657 0 0
Cell-Cell communication R-HSA-1500931 3.139067e-11 10.503 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.327094e-11 10.199 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.173624e-10 9.663 0 0
Cell junction organization R-HSA-446728 3.277427e-10 9.484 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.718437e-10 9.173 0 0
Regulation of CDH1 Function R-HSA-9764561 1.459490e-09 8.836 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.773517e-09 8.751 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.773517e-09 8.751 0 0
Interleukin-12 signaling R-HSA-9020591 2.304949e-09 8.637 0 0
Mitotic Anaphase R-HSA-68882 3.535181e-09 8.452 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.918558e-09 8.407 0 0
Recycling pathway of L1 R-HSA-437239 5.990377e-09 8.223 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.355333e-09 8.078 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.355333e-09 8.078 0 0
L1CAM interactions R-HSA-373760 8.052333e-09 8.094 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.028219e-08 7.988 0 0
Mitotic Prometaphase R-HSA-68877 1.242730e-08 7.906 0 0
Apoptosis R-HSA-109581 1.771346e-08 7.752 0 0
Interleukin-12 family signaling R-HSA-447115 2.048382e-08 7.689 0 0
Separation of Sister Chromatids R-HSA-2467813 2.224767e-08 7.653 0 0
Apoptotic execution phase R-HSA-75153 3.222316e-08 7.492 0 0
Influenza Infection R-HSA-168255 3.533647e-08 7.452 0 0
Programmed Cell Death R-HSA-5357801 4.627954e-08 7.335 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.401508e-08 7.267 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.117565e-08 7.148 0 0
G2/M Transition R-HSA-69275 7.276368e-08 7.138 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.887961e-08 7.051 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.054224e-07 6.977 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.689260e-07 6.772 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.766384e-07 6.753 0 0
Interferon Signaling R-HSA-913531 1.795764e-07 6.746 0 0
Signaling by Interleukins R-HSA-449147 1.748122e-07 6.757 0 0
Translation initiation complex formation R-HSA-72649 1.857635e-07 6.731 0 0
Ribosome-associated quality control R-HSA-9948299 1.986168e-07 6.702 0 0
Cell-cell junction organization R-HSA-421270 2.787504e-07 6.555 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.953038e-07 6.530 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.516516e-07 6.454 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.907510e-07 6.408 0 0
Host Interactions of HIV factors R-HSA-162909 3.939062e-07 6.405 0 0
Peptide chain elongation R-HSA-156902 5.406585e-07 6.267 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.406585e-07 6.267 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.213553e-07 6.283 0 0
PKR-mediated signaling R-HSA-9833482 6.472049e-07 6.189 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.181509e-07 6.144 0 0
Immune System R-HSA-168256 7.492901e-07 6.125 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.620126e-07 6.118 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.620126e-07 6.118 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.328175e-07 6.079 0 0
Mitotic Prophase R-HSA-68875 9.395762e-07 6.027 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.134529e-06 5.945 0 0
Signaling by ROBO receptors R-HSA-376176 1.137197e-06 5.944 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.183378e-06 5.927 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.269761e-06 5.896 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.269761e-06 5.896 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.269761e-06 5.896 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.269761e-06 5.896 0 0
Signaling by RAS mutants R-HSA-6802949 1.269761e-06 5.896 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.270058e-06 5.896 0 0
Cell Cycle Checkpoints R-HSA-69620 1.372857e-06 5.862 0 0
Adherens junctions interactions R-HSA-418990 1.439078e-06 5.842 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.516082e-06 5.819 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.462672e-06 5.835 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.631364e-06 5.787 0 0
Regulation of signaling by CBL R-HSA-912631 1.669761e-06 5.777 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.858541e-06 5.731 0 0
Aggrephagy R-HSA-9646399 1.782856e-06 5.749 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.904313e-06 5.720 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.348223e-06 5.629 0 0
Signaling by ALK in cancer R-HSA-9700206 2.348223e-06 5.629 0 0
Signal Transduction R-HSA-162582 2.543080e-06 5.595 1 0
Signaling by RAF1 mutants R-HSA-9656223 2.716404e-06 5.566 0 0
PECAM1 interactions R-HSA-210990 3.791020e-06 5.421 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.872762e-06 5.412 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.995392e-06 5.398 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.824608e-06 5.317 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.792016e-06 5.319 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.916915e-06 5.228 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.379042e-06 5.195 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.685980e-06 5.175 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.433506e-06 5.129 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.556805e-06 5.122 0 0
HIV Infection R-HSA-162906 8.163833e-06 5.088 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.143055e-06 5.039 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.060322e-05 4.975 0 0
mRNA Splicing R-HSA-72172 1.143175e-05 4.942 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.101295e-05 4.958 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.155526e-05 4.937 0 0
rRNA processing R-HSA-72312 1.167718e-05 4.933 0 0
Glycolysis R-HSA-70171 1.331817e-05 4.876 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.405861e-05 4.852 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.760291e-05 4.754 0 0
Cellular response to starvation R-HSA-9711097 1.784580e-05 4.748 0 0
Developmental Biology R-HSA-1266738 1.744506e-05 4.758 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.869647e-05 4.728 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.880442e-05 4.726 0 0
Regulation of KIT signaling R-HSA-1433559 1.893282e-05 4.723 0 0
Viral Infection Pathways R-HSA-9824446 2.248503e-05 4.648 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.272352e-05 4.644 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.272352e-05 4.644 0 0
Gap junction trafficking R-HSA-190828 2.661500e-05 4.575 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.662077e-05 4.575 0 0
Eukaryotic Translation Termination R-HSA-72764 2.810242e-05 4.551 0 0
Translation R-HSA-72766 3.151831e-05 4.501 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.390755e-05 4.470 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.456485e-05 4.461 0 0
Selective autophagy R-HSA-9663891 3.783564e-05 4.422 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.974936e-05 4.303 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.201421e-05 4.284 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.201421e-05 4.284 0 0
Neutrophil degranulation R-HSA-6798695 5.482414e-05 4.261 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.626730e-05 4.250 0 0
Selenocysteine synthesis R-HSA-2408557 5.337679e-05 4.273 0 0
Degradation of CDH1 R-HSA-9766229 6.009087e-05 4.221 0 0
Gap junction trafficking and regulation R-HSA-157858 6.009087e-05 4.221 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.091734e-05 4.215 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.407694e-05 4.193 0 0
Viral mRNA Translation R-HSA-192823 6.541906e-05 4.184 0 0
Signaling by ERBB2 R-HSA-1227986 6.558326e-05 4.183 0 0
EPH-Ephrin signaling R-HSA-2682334 6.591183e-05 4.181 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.906563e-05 4.161 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.514795e-05 4.124 0 0
MAP2K and MAPK activation R-HSA-5674135 8.192898e-05 4.087 0 0
G2/M Checkpoints R-HSA-69481 8.456085e-05 4.073 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.192898e-05 4.087 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.490278e-05 4.071 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.723621e-05 4.059 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.969170e-05 4.047 0 0
Regulation of PTEN localization R-HSA-8948747 9.399528e-05 4.027 0 0
Semaphorin interactions R-HSA-373755 9.786660e-05 4.009 0 0
Glucose metabolism R-HSA-70326 1.000150e-04 4.000 0 0
Cellular Senescence R-HSA-2559583 1.051739e-04 3.978 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.065221e-04 3.973 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.073864e-04 3.969 0 0
Centrosome maturation R-HSA-380287 1.077417e-04 3.968 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.077417e-04 3.968 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.321333e-04 3.879 0 0
Autophagy R-HSA-9612973 1.289243e-04 3.890 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.328900e-04 3.877 0 0
HIV Life Cycle R-HSA-162587 1.388881e-04 3.857 0 0
Muscle contraction R-HSA-397014 1.402611e-04 3.853 0 0
Formation of annular gap junctions R-HSA-196025 1.460294e-04 3.836 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.460294e-04 3.836 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.519325e-04 3.818 0 0
Co-inhibition by PD-1 R-HSA-389948 1.547477e-04 3.810 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.609494e-04 3.793 0 0
Hedgehog 'off' state R-HSA-5610787 1.638969e-04 3.785 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.820311e-04 3.740 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.838742e-04 3.735 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.838742e-04 3.735 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.892790e-04 3.723 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.959947e-04 3.708 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.978917e-04 3.704 0 0
Gap junction degradation R-HSA-190873 2.176561e-04 3.662 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.283586e-04 3.641 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.306628e-04 3.637 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.343128e-04 3.630 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.363900e-04 3.626 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.575600e-04 3.589 0 0
MAPK family signaling cascades R-HSA-5683057 2.656553e-04 3.576 0 0
Kinesins R-HSA-983189 2.725789e-04 3.565 0 0
DNA Damage Bypass R-HSA-73893 2.727083e-04 3.564 0 0
mTORC1-mediated signalling R-HSA-166208 2.865974e-04 3.543 1 1
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.882170e-04 3.540 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.915767e-04 3.535 0 0
Negative regulation of FLT3 R-HSA-9706369 2.994298e-04 3.524 0 0
Macroautophagy R-HSA-1632852 3.047021e-04 3.516 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.133187e-04 3.504 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.133187e-04 3.504 0 0
Josephin domain DUBs R-HSA-5689877 3.133187e-04 3.504 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.369872e-04 3.472 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.391568e-04 3.470 0 0
FLT3 Signaling R-HSA-9607240 3.391568e-04 3.470 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.487886e-04 3.457 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.527903e-04 3.452 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.056273e-04 3.392 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.021371e-04 3.396 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.609073e-04 3.443 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.282823e-04 3.368 0 0
Post NMDA receptor activation events R-HSA-438064 4.282823e-04 3.368 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.378566e-04 3.359 0 0
Membrane Trafficking R-HSA-199991 4.429056e-04 3.354 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.604141e-04 3.337 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.718663e-04 3.326 0 0
Striated Muscle Contraction R-HSA-390522 4.718663e-04 3.326 0 0
Maturation of protein E R-HSA-9694493 4.787964e-04 3.320 0 0
Maturation of protein E R-HSA-9683683 4.787964e-04 3.320 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.918994e-04 3.308 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.928679e-04 3.307 0 0
Chromatin organization R-HSA-4839726 4.961061e-04 3.304 0 0
Chromatin modifying enzymes R-HSA-3247509 5.078000e-04 3.294 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.217727e-04 3.283 0 0
Nuclear import of Rev protein R-HSA-180746 5.535618e-04 3.257 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.679464e-04 3.246 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.964810e-04 3.224 0 0
Selenoamino acid metabolism R-HSA-2408522 6.001269e-04 3.222 0 0
Hemostasis R-HSA-109582 6.030440e-04 3.220 0 0
Ephrin signaling R-HSA-3928664 6.203290e-04 3.207 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.203290e-04 3.207 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.223255e-04 3.206 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.284464e-04 3.202 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 6.628260e-04 3.179 0 0
HCMV Early Events R-HSA-9609690 7.371863e-04 3.132 0 0
Platelet degranulation R-HSA-114608 7.216144e-04 3.142 0 0
Signaling by NOTCH R-HSA-157118 6.983072e-04 3.156 0 0
Protein folding R-HSA-391251 7.442907e-04 3.128 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.509443e-04 3.124 0 0
Translesion Synthesis by POLH R-HSA-110320 7.719640e-04 3.112 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.920839e-04 3.101 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.920839e-04 3.101 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.920839e-04 3.101 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.920839e-04 3.101 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.920839e-04 3.101 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.920839e-04 3.101 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.920839e-04 3.101 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.920839e-04 3.101 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.920839e-04 3.101 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.920839e-04 3.101 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.920839e-04 3.101 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.946728e-04 3.100 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.946728e-04 3.100 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.946728e-04 3.100 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.124523e-04 3.090 0 0
Dual incision in TC-NER R-HSA-6782135 8.347856e-04 3.078 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.360093e-04 3.078 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.835338e-04 3.054 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.062044e-04 3.043 0 0
Negative regulation of MET activity R-HSA-6807004 9.507326e-04 3.022 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.507326e-04 3.022 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.159742e-03 2.936 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.150496e-03 2.939 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.150496e-03 2.939 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.127229e-03 2.948 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.154722e-03 2.938 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.154722e-03 2.938 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.095961e-03 2.960 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.002115e-03 2.999 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.038264e-03 2.984 0 0
Gene Silencing by RNA R-HSA-211000 1.013902e-03 2.994 0 0
Cilium Assembly R-HSA-5617833 1.239132e-03 2.907 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.315893e-03 2.881 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.315893e-03 2.881 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.333271e-03 2.875 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.333271e-03 2.875 0 0
Protein ubiquitination R-HSA-8852135 1.364290e-03 2.865 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.402236e-03 2.853 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.402236e-03 2.853 0 0
EGFR downregulation R-HSA-182971 1.441140e-03 2.841 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.441140e-03 2.841 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.441140e-03 2.841 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.499660e-03 2.824 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.499660e-03 2.824 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.543213e-03 2.812 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.543213e-03 2.812 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.543213e-03 2.812 0 0
Infectious disease R-HSA-5663205 1.546790e-03 2.811 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.570681e-03 2.804 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.685910e-03 2.773 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.685910e-03 2.773 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.685910e-03 2.773 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.934014e-03 2.714 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.597800e-03 2.796 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.927051e-03 2.715 0 0
Orc1 removal from chromatin R-HSA-68949 1.597800e-03 2.796 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.988970e-03 2.701 0 0
Protein methylation R-HSA-8876725 1.685910e-03 2.773 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.685910e-03 2.773 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.703206e-03 2.769 0 0
PTEN Regulation R-HSA-6807070 1.866321e-03 2.729 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.703206e-03 2.769 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.703206e-03 2.769 0 0
Ca-dependent events R-HSA-111996 1.927987e-03 2.715 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.934014e-03 2.714 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.703206e-03 2.769 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.832128e-03 2.737 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.681583e-03 2.774 0 0
Signaling by Hedgehog R-HSA-5358351 1.751729e-03 2.757 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.685910e-03 2.773 0 0
p75NTR signals via NF-kB R-HSA-193639 1.685910e-03 2.773 0 0
ALK mutants bind TKIs R-HSA-9700645 2.111776e-03 2.675 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.111776e-03 2.675 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.118379e-03 2.674 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.128515e-03 2.672 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.175511e-03 2.662 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.224858e-03 2.653 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.224858e-03 2.653 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.364857e-03 2.626 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.447332e-03 2.611 0 0
Ion homeostasis R-HSA-5578775 2.453015e-03 2.610 0 0
Nucleotide Excision Repair R-HSA-5696398 2.463268e-03 2.608 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.505160e-03 2.601 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.537659e-03 2.596 0 0
Dual Incision in GG-NER R-HSA-5696400 2.548334e-03 2.594 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.548334e-03 2.594 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.548334e-03 2.594 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.589633e-03 2.587 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.745047e-03 2.561 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.745047e-03 2.561 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.745047e-03 2.561 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.810524e-03 2.551 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.810524e-03 2.551 0 0
Pexophagy R-HSA-9664873 2.810524e-03 2.551 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.906791e-03 2.537 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.906791e-03 2.537 0 0
Regulation of Apoptosis R-HSA-169911 2.906791e-03 2.537 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.923879e-03 2.534 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.070295e-03 2.513 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.070295e-03 2.513 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.070295e-03 2.513 0 0
Signaling by Hippo R-HSA-2028269 3.153700e-03 2.501 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.240559e-03 2.489 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.738296e-03 2.427 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.424753e-03 2.465 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.339103e-03 2.476 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.302254e-03 2.366 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.305882e-03 2.481 0 0
HATs acetylate histones R-HSA-3214847 4.090165e-03 2.388 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.638875e-03 2.439 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.638875e-03 2.439 0 0
Degradation of DVL R-HSA-4641258 3.738296e-03 2.427 0 0
Calmodulin induced events R-HSA-111933 3.302629e-03 2.481 0 0
CaM pathway R-HSA-111997 3.302629e-03 2.481 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.302629e-03 2.481 0 0
Degradation of AXIN R-HSA-4641257 3.738296e-03 2.427 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.738296e-03 2.427 0 0
Signaling by VEGF R-HSA-194138 4.329795e-03 2.364 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.845141e-03 2.415 0 0
MAP kinase activation R-HSA-450294 3.993230e-03 2.399 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.376359e-03 2.359 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.216280e-03 2.375 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.652926e-03 2.437 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.297017e-03 2.482 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.332549e-03 2.363 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.302629e-03 2.481 0 0
MHC class II antigen presentation R-HSA-2132295 3.595177e-03 2.444 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.228187e-03 2.374 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.228187e-03 2.374 0 0
Signaling by NOTCH4 R-HSA-9013694 3.959592e-03 2.402 0 0
Gluconeogenesis R-HSA-70263 3.810135e-03 2.419 0 0
Diseases of programmed cell death R-HSA-9645723 4.414662e-03 2.355 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.444783e-03 2.352 0 0
DNA Replication R-HSA-69306 4.486724e-03 2.348 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.486724e-03 2.348 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.538885e-03 2.343 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.538885e-03 2.343 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.545710e-03 2.342 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.651922e-03 2.332 0 0
NF-kB is activated and signals survival R-HSA-209560 4.651922e-03 2.332 0 0
UCH proteinases R-HSA-5689603 4.667877e-03 2.331 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.739105e-03 2.324 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.739105e-03 2.324 0 0
Stabilization of p53 R-HSA-69541 4.739105e-03 2.324 0 0
ER-Phagosome pathway R-HSA-1236974 4.755417e-03 2.323 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.787549e-03 2.320 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.787549e-03 2.320 0 0
Signaling by PTK6 R-HSA-8848021 4.787549e-03 2.320 0 0
Late endosomal microautophagy R-HSA-9615710 4.971806e-03 2.303 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.971806e-03 2.303 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.971806e-03 2.303 0 0
HCMV Infection R-HSA-9609646 5.007537e-03 2.300 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.169425e-03 2.287 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.169425e-03 2.287 0 0
Ion transport by P-type ATPases R-HSA-936837 5.228144e-03 2.282 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.309319e-03 2.275 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.309319e-03 2.275 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.309319e-03 2.275 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.309319e-03 2.275 0 0
Signal transduction by L1 R-HSA-445144 5.372966e-03 2.270 0 0
PCP/CE pathway R-HSA-4086400 5.472161e-03 2.262 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.677696e-03 2.246 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.696236e-03 2.244 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.746293e-03 2.241 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.819826e-03 2.235 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.819826e-03 2.235 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.819826e-03 2.235 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.819826e-03 2.235 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.929496e-03 2.227 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.929496e-03 2.227 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.262958e-03 2.203 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.262958e-03 2.203 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.309876e-03 2.200 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.309876e-03 2.200 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.454077e-03 2.190 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.454077e-03 2.190 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.454077e-03 2.190 0 0
Regulation of TP53 Activity R-HSA-5633007 6.473180e-03 2.189 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.541612e-03 2.184 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.602218e-03 2.180 0 0
DNA Double Strand Break Response R-HSA-5693606 6.740075e-03 2.171 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.871449e-03 2.163 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.877161e-03 2.163 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.897469e-03 2.161 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.168241e-03 2.145 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.168241e-03 2.145 0 0
MTOR signalling R-HSA-165159 7.330078e-03 2.135 1 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.355835e-03 2.133 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.355835e-03 2.133 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.402804e-03 2.131 0 0
Synthesis of DNA R-HSA-69239 7.421402e-03 2.130 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.523577e-03 2.124 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.523577e-03 2.124 0 0
Signaling by NOTCH3 R-HSA-9012852 7.523577e-03 2.124 0 0
Manipulation of host energy metabolism R-HSA-9636667 7.961182e-03 2.099 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.674234e-03 2.115 0 0
Recycling of eIF2:GDP R-HSA-72731 1.019407e-02 1.992 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.233636e-03 2.084 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 9.244378e-03 2.034 0 0
RAF activation R-HSA-5673000 1.034071e-02 1.985 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.221219e-03 2.085 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.821652e-03 2.008 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.546718e-03 2.068 0 0
Translesion synthesis by REV1 R-HSA-110312 1.044909e-02 1.981 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.252049e-03 2.034 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.252049e-03 2.034 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.978126e-03 2.001 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.120760e-02 1.950 0 0
Neurodegenerative Diseases R-HSA-8863678 1.120760e-02 1.950 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.961182e-03 2.099 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.850022e-03 2.105 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.912390e-03 2.050 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.912390e-03 2.050 0 0
Nef and signal transduction R-HSA-164944 7.674234e-03 2.115 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.707995e-03 2.060 0 0
Signaling by SCF-KIT R-HSA-1433557 8.115666e-03 2.091 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.803367e-03 2.055 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.870353e-03 2.006 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.678226e-03 2.115 0 0
DAG and IP3 signaling R-HSA-1489509 9.870353e-03 2.006 0 0
Interleukin-17 signaling R-HSA-448424 8.566641e-03 2.067 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.019407e-02 1.992 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.044909e-02 1.981 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 9.244378e-03 2.034 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.566641e-03 2.067 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.252049e-03 2.034 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.051109e-02 1.978 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.252049e-03 2.034 0 0
Innate Immune System R-HSA-168249 8.720696e-03 2.059 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.434313e-03 2.025 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.516901e-03 2.070 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.870353e-03 2.006 0 0
Syndecan interactions R-HSA-3000170 9.798940e-03 2.009 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.069377e-02 1.971 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.707995e-03 2.060 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 8.961568e-03 2.048 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.870353e-03 2.006 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.044909e-02 1.981 0 0
Gap junction assembly R-HSA-190861 1.034071e-02 1.985 0 0
ABC-family proteins mediated transport R-HSA-382556 1.136991e-02 1.944 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.132836e-03 2.039 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.125192e-02 1.949 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.044909e-02 1.981 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.233636e-03 2.084 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.150450e-02 1.939 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.152627e-02 1.938 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.152627e-02 1.938 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.188674e-02 1.925 0 0
Ion channel transport R-HSA-983712 1.224640e-02 1.912 0 0
Translesion synthesis by POLI R-HSA-5656121 1.240065e-02 1.907 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.240065e-02 1.907 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.240065e-02 1.907 0 0
Regulation of BACH1 activity R-HSA-9708530 1.240065e-02 1.907 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.245786e-02 1.905 0 0
PLC beta mediated events R-HSA-112043 1.245786e-02 1.905 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.280459e-02 1.893 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 1.280459e-02 1.893 0 0
FLT3 signaling in disease R-HSA-9682385 1.280459e-02 1.893 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.287991e-02 1.890 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.299935e-02 1.886 0 0
Type I hemidesmosome assembly R-HSA-446107 1.314011e-02 1.881 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.314011e-02 1.881 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.331784e-02 1.876 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.346793e-02 1.871 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.417911e-02 1.848 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.446629e-02 1.840 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.453653e-02 1.838 0 0
Translesion synthesis by POLK R-HSA-5655862 1.457093e-02 1.837 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.457093e-02 1.837 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.457093e-02 1.837 0 0
RNA Polymerase I Transcription R-HSA-73864 1.526893e-02 1.816 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.526893e-02 1.816 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.544564e-02 1.811 0 0
Homology Directed Repair R-HSA-5693538 1.561493e-02 1.806 0 0
Circadian clock R-HSA-9909396 1.570181e-02 1.804 0 0
Developmental Cell Lineages R-HSA-9734767 1.571173e-02 1.804 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.624598e-02 1.789 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.624598e-02 1.789 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.624598e-02 1.789 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.624598e-02 1.789 0 0
Vesicle-mediated transport R-HSA-5653656 1.640865e-02 1.785 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.652231e-02 1.782 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.652231e-02 1.782 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.652231e-02 1.782 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.652231e-02 1.782 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.678406e-02 1.775 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.696724e-02 1.770 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.696724e-02 1.770 0 0
Glycogen storage diseases R-HSA-3229121 1.696724e-02 1.770 0 0
S Phase R-HSA-69242 1.708730e-02 1.767 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.723000e-02 1.764 0 0
Signaling by FGFR2 R-HSA-5654738 1.742252e-02 1.759 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.821241e-02 1.740 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.821241e-02 1.740 0 0
Amyloid fiber formation R-HSA-977225 1.857868e-02 1.731 0 0
Glycogen metabolism R-HSA-8982491 1.891268e-02 1.723 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.901529e-02 1.721 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.913329e-02 1.718 0 0
G-protein mediated events R-HSA-112040 1.943188e-02 1.711 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.959602e-02 1.708 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.959602e-02 1.708 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.970290e-02 1.705 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.970290e-02 1.705 0 0
Smooth Muscle Contraction R-HSA-445355 1.970290e-02 1.705 0 0
DNA Repair R-HSA-73894 1.973866e-02 1.705 0 0
DNA methylation R-HSA-5334118 2.032965e-02 1.692 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.032965e-02 1.692 0 0
Platelet calcium homeostasis R-HSA-418360 2.032965e-02 1.692 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.032965e-02 1.692 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.070416e-02 1.684 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.070416e-02 1.684 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.081956e-02 1.682 0 0
MET interacts with TNS proteins R-HSA-8875513 2.087653e-02 1.680 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.087653e-02 1.680 0 0
ESR-mediated signaling R-HSA-8939211 2.153140e-02 1.667 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.227610e-02 1.652 0 0
Rap1 signalling R-HSA-392517 2.246275e-02 1.649 0 0
Activation of BH3-only proteins R-HSA-114452 2.260162e-02 1.646 0 0
Adaptive Immune System R-HSA-1280218 2.321536e-02 1.634 0 0
Meiosis R-HSA-1500620 2.376354e-02 1.624 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.380307e-02 1.623 0 0
SARS-CoV Infections R-HSA-9679506 2.417877e-02 1.617 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.461635e-02 1.609 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.462462e-02 1.609 0 0
Signaling by EGFR R-HSA-177929 2.471841e-02 1.607 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.471841e-02 1.607 0 0
Trafficking of AMPA receptors R-HSA-399719 2.503188e-02 1.602 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.503188e-02 1.602 0 0
Nephrin family interactions R-HSA-373753 2.557202e-02 1.592 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.557202e-02 1.592 0 0
Glycogen synthesis R-HSA-3322077 2.557202e-02 1.592 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.629730e-02 1.580 0 0
Defective pyroptosis R-HSA-9710421 2.675875e-02 1.573 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.675875e-02 1.573 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.707444e-02 1.567 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.892753e-02 1.539 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.892753e-02 1.539 0 0
Cyclin D associated events in G1 R-HSA-69231 2.901197e-02 1.537 0 0
G1 Phase R-HSA-69236 2.901197e-02 1.537 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.921346e-02 1.534 0 0
MTF1 activates gene expression R-HSA-5660489 2.921346e-02 1.534 0 0
Interferon alpha/beta signaling R-HSA-909733 2.993580e-02 1.524 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.019147e-02 1.520 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.037985e-02 1.517 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.037985e-02 1.517 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.037985e-02 1.517 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.037985e-02 1.517 0 0
Peroxisomal protein import R-HSA-9033241 3.054600e-02 1.515 0 0
snRNP Assembly R-HSA-191859 3.054600e-02 1.515 0 0
Metabolism of non-coding RNA R-HSA-194441 3.054600e-02 1.515 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.064535e-02 1.514 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.064535e-02 1.514 0 0
Signaling by ERBB4 R-HSA-1236394 3.064535e-02 1.514 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.864437e-02 1.413 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.905999e-02 1.309 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.035841e-02 1.219 0 0
CREB phosphorylation R-HSA-199920 6.035841e-02 1.219 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.035841e-02 1.219 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.448636e-02 1.462 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.448636e-02 1.462 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.007832e-02 1.397 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.253851e-02 1.280 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.253209e-02 1.488 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.253209e-02 1.488 0 0
FGFR2 alternative splicing R-HSA-6803529 3.638767e-02 1.439 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.638767e-02 1.439 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.485565e-02 1.348 0 0
Tight junction interactions R-HSA-420029 4.946796e-02 1.306 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.944351e-02 1.226 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.944351e-02 1.226 0 0
Cristae formation R-HSA-8949613 5.944351e-02 1.226 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.944351e-02 1.226 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.857531e-02 1.232 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.288182e-02 1.201 0 0
mRNA 3'-end processing R-HSA-72187 5.154656e-02 1.288 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.154656e-02 1.288 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.154656e-02 1.288 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.494705e-02 1.260 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.952695e-02 1.225 0 0
Ub-specific processing proteases R-HSA-5689880 4.809817e-02 1.318 0 0
Signaling by MET R-HSA-6806834 4.325827e-02 1.364 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.288182e-02 1.201 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.639515e-02 1.439 0 0
DCC mediated attractive signaling R-HSA-418885 5.253851e-02 1.280 0 0
Metalloprotease DUBs R-HSA-5689901 5.433120e-02 1.265 0 0
HDMs demethylate histones R-HSA-3214842 4.946796e-02 1.306 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.360082e-02 1.271 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.864437e-02 1.413 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.946796e-02 1.306 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.444312e-02 1.264 0 0
Chromosome Maintenance R-HSA-73886 3.934071e-02 1.405 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.288182e-02 1.201 0 0
Long-term potentiation R-HSA-9620244 4.946796e-02 1.306 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.638767e-02 1.439 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.938632e-02 1.226 0 0
Co-stimulation by CD28 R-HSA-389356 3.925636e-02 1.406 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.670252e-02 1.331 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.609884e-02 1.336 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.253209e-02 1.488 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.944351e-02 1.226 0 0
Meiotic recombination R-HSA-912446 4.827802e-02 1.316 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.325827e-02 1.364 0 0
Toll-like Receptor Cascades R-HSA-168898 4.836762e-02 1.315 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.235728e-02 1.373 0 0
Platelet homeostasis R-HSA-418346 3.858789e-02 1.414 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.007832e-02 1.397 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.639515e-02 1.439 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.103186e-02 1.292 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.049541e-02 1.393 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.475806e-02 1.262 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.475806e-02 1.262 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.475806e-02 1.262 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.433303e-02 1.353 0 0
Gene expression (Transcription) R-HSA-74160 4.568027e-02 1.340 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.285826e-02 1.277 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.992121e-02 1.222 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.670252e-02 1.331 0 0
tRNA processing in the nucleus R-HSA-6784531 3.723236e-02 1.429 0 0
Signaling by KIT in disease R-HSA-9669938 3.638767e-02 1.439 0 0
Mitophagy R-HSA-5205647 3.639515e-02 1.439 0 0
Assembly Of The HIV Virion R-HSA-175474 3.253209e-02 1.488 0 0
Disease R-HSA-1643685 3.986230e-02 1.399 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.490560e-02 1.457 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.433120e-02 1.265 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.154656e-02 1.288 0 0
Sensory processing of sound R-HSA-9659379 4.095150e-02 1.388 0 0
Regulated Necrosis R-HSA-5218859 5.332716e-02 1.273 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.944351e-02 1.226 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.485127e-02 1.348 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.638767e-02 1.439 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.905999e-02 1.309 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.253209e-02 1.488 0 0
Cellular response to hypoxia R-HSA-1234174 4.481612e-02 1.349 0 0
Interleukin-7 signaling R-HSA-1266695 4.946796e-02 1.306 0 0
Signaling by NOTCH2 R-HSA-1980145 3.639515e-02 1.439 0 0
ABC transporter disorders R-HSA-5619084 3.872797e-02 1.412 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.267729e-02 1.486 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.723236e-02 1.429 0 0
Cellular response to chemical stress R-HSA-9711123 5.562945e-02 1.255 0 0
Hedgehog 'on' state R-HSA-5632684 6.278618e-02 1.202 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.952695e-02 1.225 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.287075e-02 1.368 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.952695e-02 1.225 0 0
Suppression of phagosomal maturation R-HSA-9637687 5.433120e-02 1.265 0 0
Signaling by FGFR R-HSA-190236 5.475806e-02 1.262 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.180461e-02 1.209 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.639252e-02 1.334 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.934071e-02 1.405 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.422162e-02 1.192 0 0
HIV elongation arrest and recovery R-HSA-167287 6.480238e-02 1.188 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.480238e-02 1.188 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.594412e-02 1.181 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.594412e-02 1.181 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.662987e-02 1.176 0 0
Mitochondrial biogenesis R-HSA-1592230 6.757123e-02 1.170 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.040471e-02 1.152 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.040471e-02 1.152 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.040471e-02 1.152 0 0
Opioid Signalling R-HSA-111885 7.111255e-02 1.148 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.201510e-02 1.143 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.244463e-02 1.140 0 0
Disinhibition of SNARE formation R-HSA-114516 7.244463e-02 1.140 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.244463e-02 1.140 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.244463e-02 1.140 0 0
CHL1 interactions R-HSA-447041 7.244463e-02 1.140 0 0
MECP2 regulates transcription factors R-HSA-9022707 7.244463e-02 1.140 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.300181e-02 1.137 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.300181e-02 1.137 0 0
Signaling by WNT R-HSA-195721 7.372557e-02 1.132 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.393917e-02 1.131 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.425560e-02 1.129 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.425560e-02 1.129 0 0
Downstream TCR signaling R-HSA-202424 7.433713e-02 1.129 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.624678e-02 1.118 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.624678e-02 1.118 0 0
Signaling by FGFR4 R-HSA-5654743 7.683970e-02 1.114 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 7.696252e-02 1.114 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.769322e-02 1.110 0 0
Protein localization R-HSA-9609507 7.922342e-02 1.101 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.929688e-02 1.101 0 0
IRE1alpha activates chaperones R-HSA-381070 8.113859e-02 1.091 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.164786e-02 1.088 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.164786e-02 1.088 0 0
Death Receptor Signaling R-HSA-73887 8.183003e-02 1.087 0 0
Proteasome assembly R-HSA-9907900 8.183434e-02 1.087 0 0
RMTs methylate histone arginines R-HSA-3214858 8.183434e-02 1.087 0 0
PKA activation in glucagon signalling R-HSA-164378 8.224897e-02 1.085 0 0
Platelet sensitization by LDL R-HSA-432142 8.224897e-02 1.085 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.224897e-02 1.085 0 0
Budding and maturation of HIV virion R-HSA-162588 8.232436e-02 1.084 0 0
Regulation of PTEN gene transcription R-HSA-8943724 8.246234e-02 1.084 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.418361e-02 1.075 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.418361e-02 1.075 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.418361e-02 1.075 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 8.418361e-02 1.075 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 8.418361e-02 1.075 0 0
TICAM1 deficiency - HSE R-HSA-5602566 8.418361e-02 1.075 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.418361e-02 1.075 0 0
Hereditary fructose intolerance R-HSA-5657560 8.418361e-02 1.075 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.418361e-02 1.075 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 8.418361e-02 1.075 0 0
Inhibition of PKR R-HSA-169131 8.418361e-02 1.075 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 8.523019e-02 1.069 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.523019e-02 1.069 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.523019e-02 1.069 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.523019e-02 1.069 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 8.523019e-02 1.069 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.692033e-02 1.061 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.699720e-02 1.060 0 0
Signaling by FGFR3 R-HSA-5654741 8.699720e-02 1.060 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.863269e-02 1.052 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.059461e-02 1.043 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.059461e-02 1.043 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.059461e-02 1.043 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.232619e-02 1.035 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.232619e-02 1.035 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.232619e-02 1.035 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.232619e-02 1.035 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.275956e-02 1.033 0 0
TCR signaling R-HSA-202403 9.365891e-02 1.028 0 0
G1/S Transition R-HSA-69206 9.411333e-02 1.026 0 0
Integrin signaling R-HSA-354192 9.516655e-02 1.022 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 9.516655e-02 1.022 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.516655e-02 1.022 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.516655e-02 1.022 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.523951e-02 1.021 0 0
Signaling by TGFB family members R-HSA-9006936 9.859215e-02 1.006 0 0
Lipophagy R-HSA-9613354 9.863275e-02 1.006 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 9.863275e-02 1.006 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 9.863275e-02 1.006 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 9.863275e-02 1.006 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 9.863275e-02 1.006 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.927650e-02 1.003 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 9.927650e-02 1.003 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.010679e-01 0.995 0 0
Intraflagellar transport R-HSA-5620924 1.034729e-01 0.985 0 0
NGF-stimulated transcription R-HSA-9031628 1.034729e-01 0.985 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.036758e-01 0.984 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.036758e-01 0.984 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.041640e-01 0.982 0 0
Deubiquitination R-HSA-5688426 1.044181e-01 0.981 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.044660e-01 0.981 0 0
Telomere Maintenance R-HSA-157579 1.077394e-01 0.968 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.077394e-01 0.968 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.088880e-01 0.963 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.088880e-01 0.963 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.088880e-01 0.963 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 1.092852e-01 0.961 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 1.101865e-01 0.958 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.125757e-01 0.949 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.125757e-01 0.949 0 0
2-LTR circle formation R-HSA-164843 1.125757e-01 0.949 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.125757e-01 0.949 0 0
Regulation of CDH11 function R-HSA-9762292 1.125757e-01 0.949 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.125757e-01 0.949 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.130348e-01 0.947 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.159500e-01 0.936 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.160631e-01 0.935 0 0
PERK regulates gene expression R-HSA-381042 1.160631e-01 0.935 0 0
Oncogene Induced Senescence R-HSA-2559585 1.160631e-01 0.935 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.163474e-01 0.934 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.164563e-01 0.934 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.175825e-01 0.930 0 0
Signaling by NTRKs R-HSA-166520 1.199360e-01 0.921 0 0
Transcription of the HIV genome R-HSA-167172 1.216844e-01 0.915 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.216844e-01 0.915 0 0
GPVI-mediated activation cascade R-HSA-114604 1.234390e-01 0.909 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.235829e-01 0.908 0 0
TRAF3 deficiency - HSE R-HSA-5602571 1.235829e-01 0.908 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.235829e-01 0.908 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.235829e-01 0.908 0 0
Bicarbonate transporters R-HSA-425381 1.269880e-01 0.896 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.269880e-01 0.896 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.310087e-01 0.883 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.322924e-01 0.878 0 0
Meiotic synapsis R-HSA-1221632 1.340534e-01 0.873 0 0
Disorders of transmembrane transporters R-HSA-5619115 1.354815e-01 0.868 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.365578e-01 0.865 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.370305e-01 0.863 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.370305e-01 0.863 0 0
Growth hormone receptor signaling R-HSA-982772 1.370305e-01 0.863 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.383985e-01 0.859 0 0
Integration of provirus R-HSA-162592 1.418036e-01 0.848 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.418036e-01 0.848 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.418036e-01 0.848 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.432943e-01 0.844 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.432943e-01 0.844 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.441967e-01 0.841 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.467003e-01 0.834 0 0
Pentose phosphate pathway R-HSA-71336 1.467003e-01 0.834 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.467003e-01 0.834 0 0
RAS processing R-HSA-9648002 1.467003e-01 0.834 0 0
Deadenylation of mRNA R-HSA-429947 1.471394e-01 0.832 0 0
HDACs deacetylate histones R-HSA-3214815 1.472985e-01 0.832 0 0
G alpha (z) signalling events R-HSA-418597 1.472985e-01 0.832 0 0
Extracellular matrix organization R-HSA-1474244 1.478164e-01 0.830 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 1.501043e-01 0.824 0 0
NRAGE signals death through JNK R-HSA-193648 1.541224e-01 0.812 0 0
TNF signaling R-HSA-75893 1.541224e-01 0.812 0 0
Signaling by FGFR1 R-HSA-5654736 1.541224e-01 0.812 0 0
HIV Transcription Elongation R-HSA-167169 1.548071e-01 0.810 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.548071e-01 0.810 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.548071e-01 0.810 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.548071e-01 0.810 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.569612e-01 0.804 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.569612e-01 0.804 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 1.574815e-01 0.803 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.574815e-01 0.803 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.574815e-01 0.803 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.574815e-01 0.803 0 0
Parasite infection R-HSA-9664407 1.587727e-01 0.799 0 0
Leishmania phagocytosis R-HSA-9664417 1.587727e-01 0.799 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.587727e-01 0.799 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.612895e-01 0.792 0 0
Signalling to ERK5 R-HSA-198765 1.612895e-01 0.792 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.612895e-01 0.792 0 0
Iron uptake and transport R-HSA-917937 1.622372e-01 0.790 0 0
Stimuli-sensing channels R-HSA-2672351 1.630002e-01 0.788 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.631356e-01 0.787 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 1.663705e-01 0.779 0 0
MET activates PTK2 signaling R-HSA-8874081 1.680394e-01 0.775 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.680394e-01 0.775 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.715037e-01 0.766 0 0
HIV Transcription Initiation R-HSA-167161 1.715037e-01 0.766 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.715037e-01 0.766 0 0
Translation of Structural Proteins R-HSA-9683701 1.715037e-01 0.766 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.724041e-01 0.763 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.724041e-01 0.763 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.724041e-01 0.763 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.777495e-01 0.750 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.787960e-01 0.748 0 0
Parasitic Infection Pathways R-HSA-9824443 1.797977e-01 0.745 0 0
Leishmania infection R-HSA-9658195 1.797977e-01 0.745 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.810021e-01 0.742 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.835602e-01 0.736 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.880799e-01 0.726 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.880799e-01 0.726 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.880799e-01 0.726 0 0
Signal regulatory protein family interactions R-HSA-391160 1.880799e-01 0.726 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.887909e-01 0.724 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.897343e-01 0.722 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.942905e-01 0.712 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.973760e-01 0.705 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.973760e-01 0.705 0 0
MET activates PTPN11 R-HSA-8865999 1.973760e-01 0.705 0 0
MET activates STAT3 R-HSA-8875791 1.973760e-01 0.705 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.973760e-01 0.705 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 1.973760e-01 0.705 0 0
Histamine receptors R-HSA-390650 1.973760e-01 0.705 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.976086e-01 0.704 0 0
Netrin-1 signaling R-HSA-373752 1.976358e-01 0.704 0 0
Reproduction R-HSA-1474165 1.980735e-01 0.703 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.009722e-01 0.697 0 0
Cardiac conduction R-HSA-5576891 2.032341e-01 0.692 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 2.039399e-01 0.690 0 0
Erythropoietin activates RAS R-HSA-9027284 2.039399e-01 0.690 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.039399e-01 0.690 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.039399e-01 0.690 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.039399e-01 0.690 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.066038e-01 0.685 0 0
Nucleosome assembly R-HSA-774815 2.066038e-01 0.685 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.066038e-01 0.685 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.066038e-01 0.685 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.066038e-01 0.685 0 0
Metabolism of proteins R-HSA-392499 2.093635e-01 0.679 0 0
Activation of the pre-replicative complex R-HSA-68962 2.120887e-01 0.673 0 0
Interleukin-1 family signaling R-HSA-446652 2.197435e-01 0.658 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.199395e-01 0.658 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.199395e-01 0.658 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.234944e-01 0.651 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.248767e-01 0.648 0 0
Interleukin-1 signaling R-HSA-9020702 2.262916e-01 0.645 0 0
RNA Polymerase II Transcription R-HSA-73857 2.266336e-01 0.645 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.298705e-01 0.639 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.319120e-01 0.635 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.319120e-01 0.635 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.319120e-01 0.635 0 0
NADE modulates death signalling R-HSA-205025 2.319120e-01 0.635 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.319120e-01 0.635 0 0
Interleukin-38 signaling R-HSA-9007892 2.319120e-01 0.635 0 0
GPER1 signaling R-HSA-9634597 2.341653e-01 0.630 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.341653e-01 0.630 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.349724e-01 0.629 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.349724e-01 0.629 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.360374e-01 0.627 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 2.360374e-01 0.627 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.360374e-01 0.627 0 0
Response to metal ions R-HSA-5660526 2.360374e-01 0.627 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.435444e-01 0.613 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.465735e-01 0.608 0 0
Pyruvate metabolism R-HSA-70268 2.498824e-01 0.602 0 0
RSV-host interactions R-HSA-9833110 2.521189e-01 0.598 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.521955e-01 0.598 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.521955e-01 0.598 0 0
Transmission across Chemical Synapses R-HSA-112315 2.562324e-01 0.591 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.582608e-01 0.588 0 0
Miscellaneous transport and binding events R-HSA-5223345 2.582608e-01 0.588 0 0
IRS activation R-HSA-74713 2.649639e-01 0.577 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.649639e-01 0.577 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.649639e-01 0.577 0 0
G2 Phase R-HSA-68911 2.649639e-01 0.577 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.649639e-01 0.577 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.649639e-01 0.577 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 2.649639e-01 0.577 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.649639e-01 0.577 0 0
Muscarinic acetylcholine receptors R-HSA-390648 2.649639e-01 0.577 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.649639e-01 0.577 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.649639e-01 0.577 0 0
Reelin signalling pathway R-HSA-8866376 2.649639e-01 0.577 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.649639e-01 0.577 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.649639e-01 0.577 0 0
Co-inhibition by BTLA R-HSA-9927353 2.649639e-01 0.577 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.683789e-01 0.571 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.683789e-01 0.571 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.683789e-01 0.571 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.683789e-01 0.571 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.683789e-01 0.571 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.683789e-01 0.571 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.721451e-01 0.565 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.753973e-01 0.560 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.792132e-01 0.554 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.845557e-01 0.546 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 2.845557e-01 0.546 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.845557e-01 0.546 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.845557e-01 0.546 0 0
The NLRP3 inflammasome R-HSA-844456 2.845557e-01 0.546 0 0
Generic Transcription Pathway R-HSA-212436 2.873351e-01 0.542 0 0
RET signaling R-HSA-8853659 2.936973e-01 0.532 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.965955e-01 0.528 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.965955e-01 0.528 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.965955e-01 0.528 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.965955e-01 0.528 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.965955e-01 0.528 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.965955e-01 0.528 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.965955e-01 0.528 0 0
Pentose phosphate pathway disease R-HSA-6791465 2.965955e-01 0.528 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.965955e-01 0.528 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.965955e-01 0.528 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.965955e-01 0.528 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.965955e-01 0.528 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.965955e-01 0.528 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.006964e-01 0.522 0 0
Protein hydroxylation R-HSA-9629569 3.006964e-01 0.522 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.006964e-01 0.522 0 0
Mitochondrial protein degradation R-HSA-9837999 3.092735e-01 0.510 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 3.110705e-01 0.507 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.167744e-01 0.499 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.167744e-01 0.499 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.167744e-01 0.499 0 0
Basigin interactions R-HSA-210991 3.167744e-01 0.499 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.167744e-01 0.499 0 0
MET promotes cell motility R-HSA-8875878 3.174997e-01 0.498 0 0
Translation of Structural Proteins R-HSA-9694635 3.198362e-01 0.495 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.268676e-01 0.486 0 0
Signaling by LTK in cancer R-HSA-9842640 3.268676e-01 0.486 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.268676e-01 0.486 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.268676e-01 0.486 0 0
MET Receptor Activation R-HSA-6806942 3.268676e-01 0.486 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.268676e-01 0.486 0 0
Neurofascin interactions R-HSA-447043 3.268676e-01 0.486 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.268676e-01 0.486 0 0
Integrin cell surface interactions R-HSA-216083 3.283819e-01 0.484 0 0
G alpha (12/13) signalling events R-HSA-416482 3.283819e-01 0.484 0 0
Signaling by ALK R-HSA-201556 3.294166e-01 0.482 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.294166e-01 0.482 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.413285e-01 0.467 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.486462e-01 0.458 0 0
LDL clearance R-HSA-8964038 3.486462e-01 0.458 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.486462e-01 0.458 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.504673e-01 0.455 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.504673e-01 0.455 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.504673e-01 0.455 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.504673e-01 0.455 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.504673e-01 0.455 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.558388e-01 0.449 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.558388e-01 0.449 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.558388e-01 0.449 0 0
SOS-mediated signalling R-HSA-112412 3.558388e-01 0.449 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.558388e-01 0.449 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.558388e-01 0.449 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.558388e-01 0.449 0 0
VLDL clearance R-HSA-8964046 3.558388e-01 0.449 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.558388e-01 0.449 0 0
Integration of energy metabolism R-HSA-163685 3.604790e-01 0.443 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.643978e-01 0.438 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.643978e-01 0.438 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.643978e-01 0.438 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.643978e-01 0.438 0 0
HCMV Late Events R-HSA-9610379 3.646204e-01 0.438 0 0
Neddylation R-HSA-8951664 3.722657e-01 0.429 0 0
Interferon gamma signaling R-HSA-877300 3.769051e-01 0.424 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.769259e-01 0.424 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.800014e-01 0.420 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.813177e-01 0.419 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.835647e-01 0.416 0 0
phospho-PLA2 pathway R-HSA-111995 3.835647e-01 0.416 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.835647e-01 0.416 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.835647e-01 0.416 0 0
MET receptor recycling R-HSA-8875656 3.835647e-01 0.416 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.835647e-01 0.416 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 3.835647e-01 0.416 0 0
Adrenoceptors R-HSA-390696 3.835647e-01 0.416 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.835647e-01 0.416 0 0
TBC/RABGAPs R-HSA-8854214 3.887121e-01 0.410 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.954408e-01 0.403 0 0
Laminin interactions R-HSA-3000157 3.954408e-01 0.403 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 3.954408e-01 0.403 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.974828e-01 0.401 0 0
Amine ligand-binding receptors R-HSA-375280 4.004431e-01 0.397 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 4.057734e-01 0.392 0 0
Calcineurin activates NFAT R-HSA-2025928 4.100988e-01 0.387 0 0
Unwinding of DNA R-HSA-176974 4.100988e-01 0.387 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.100988e-01 0.387 0 0
ARMS-mediated activation R-HSA-170984 4.100988e-01 0.387 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.100988e-01 0.387 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.100988e-01 0.387 0 0
WNT mediated activation of DVL R-HSA-201688 4.100988e-01 0.387 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.100988e-01 0.387 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.100988e-01 0.387 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.107012e-01 0.386 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.107012e-01 0.386 0 0
Myogenesis R-HSA-525793 4.107012e-01 0.386 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.107012e-01 0.386 0 0
TRP channels R-HSA-3295583 4.107012e-01 0.386 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.121102e-01 0.385 0 0
Somitogenesis R-HSA-9824272 4.121102e-01 0.385 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.187455e-01 0.378 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.187455e-01 0.378 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.187455e-01 0.378 0 0
FCERI mediated NF-kB activation R-HSA-2871837 4.196458e-01 0.377 0 0
Packaging Of Telomere Ends R-HSA-171306 4.257694e-01 0.371 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.257694e-01 0.371 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.257694e-01 0.371 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.354924e-01 0.361 0 0
PI3K/AKT activation R-HSA-198203 4.354924e-01 0.361 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 4.354924e-01 0.361 0 0
DNA replication initiation R-HSA-68952 4.354924e-01 0.361 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.354924e-01 0.361 0 0
Signal attenuation R-HSA-74749 4.354924e-01 0.361 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.354924e-01 0.361 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.354924e-01 0.361 0 0
Signaling by Leptin R-HSA-2586552 4.354924e-01 0.361 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.406337e-01 0.356 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.406337e-01 0.356 0 0
Telomere Extension By Telomerase R-HSA-171319 4.406337e-01 0.356 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.406337e-01 0.356 0 0
Inflammasomes R-HSA-622312 4.406337e-01 0.356 0 0
tRNA processing R-HSA-72306 4.508587e-01 0.346 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.540058e-01 0.343 0 0
Signaling by Erythropoietin R-HSA-9006335 4.552838e-01 0.342 0 0
mRNA Capping R-HSA-72086 4.552838e-01 0.342 0 0
DARPP-32 events R-HSA-180024 4.552838e-01 0.342 0 0
Glucagon-type ligand receptors R-HSA-420092 4.552838e-01 0.342 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.589679e-01 0.338 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.597943e-01 0.337 0 0
vRNP Assembly R-HSA-192905 4.597943e-01 0.337 0 0
Conjugation of benzoate with glycine R-HSA-177135 4.597943e-01 0.337 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.597943e-01 0.337 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.597943e-01 0.337 0 0
Interleukin-2 signaling R-HSA-9020558 4.597943e-01 0.337 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.597943e-01 0.337 0 0
Inositol phosphate metabolism R-HSA-1483249 4.631204e-01 0.334 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 4.652693e-01 0.332 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 4.692239e-01 0.329 0 0
Leishmania parasite growth and survival R-HSA-9664433 4.692239e-01 0.329 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.697105e-01 0.328 0 0
DAP12 signaling R-HSA-2424491 4.697105e-01 0.328 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.697105e-01 0.328 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.697105e-01 0.328 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.697105e-01 0.328 0 0
Interleukin-37 signaling R-HSA-9008059 4.697105e-01 0.328 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 4.719749e-01 0.326 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.830514e-01 0.316 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 4.830514e-01 0.316 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.830514e-01 0.316 0 0
Plasmalogen biosynthesis R-HSA-75896 4.830514e-01 0.316 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.830514e-01 0.316 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 4.830514e-01 0.316 0 0
Activation of RAC1 R-HSA-428540 4.830514e-01 0.316 0 0
Sodium/Calcium exchangers R-HSA-425561 4.830514e-01 0.316 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.830514e-01 0.316 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 4.839060e-01 0.315 0 0
Molecules associated with elastic fibres R-HSA-2129379 4.839060e-01 0.315 0 0
Signaling by FGFR in disease R-HSA-1226099 4.862355e-01 0.313 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.913684e-01 0.309 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.955593e-01 0.305 0 0
DNA strand elongation R-HSA-69190 4.978634e-01 0.303 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.978634e-01 0.303 0 0
Signaling by NOTCH1 R-HSA-1980143 5.048106e-01 0.297 0 0
MET activates RAS signaling R-HSA-8851805 5.053086e-01 0.296 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.053086e-01 0.296 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.053086e-01 0.296 0 0
Conjugation of salicylate with glycine R-HSA-177128 5.053086e-01 0.296 0 0
Polymerase switching R-HSA-69091 5.053086e-01 0.296 0 0
Leading Strand Synthesis R-HSA-69109 5.053086e-01 0.296 0 0
Regulation of IFNG signaling R-HSA-877312 5.053086e-01 0.296 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.053086e-01 0.296 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.053086e-01 0.296 0 0
OAS antiviral response R-HSA-8983711 5.053086e-01 0.296 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.115769e-01 0.291 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.115769e-01 0.291 0 0
Rab regulation of trafficking R-HSA-9007101 5.155055e-01 0.288 0 0
Regulation of insulin secretion R-HSA-422356 5.228473e-01 0.282 0 0
Glutamate and glutamine metabolism R-HSA-8964539 5.250418e-01 0.280 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.250418e-01 0.280 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.250418e-01 0.280 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.266088e-01 0.279 0 0
Formation of axial mesoderm R-HSA-9796292 5.266088e-01 0.279 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.266088e-01 0.279 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.266088e-01 0.279 0 0
Frs2-mediated activation R-HSA-170968 5.266088e-01 0.279 0 0
Interleukin-6 signaling R-HSA-1059683 5.266088e-01 0.279 0 0
FOXO-mediated transcription R-HSA-9614085 5.308593e-01 0.275 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.382538e-01 0.269 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.382538e-01 0.269 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.382538e-01 0.269 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 5.445512e-01 0.264 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.446283e-01 0.264 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.466993e-01 0.262 0 0
Removal of the Flap Intermediate R-HSA-69166 5.469931e-01 0.262 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.469931e-01 0.262 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.469931e-01 0.262 0 0
Hydrolysis of LPC R-HSA-1483115 5.469931e-01 0.262 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.469931e-01 0.262 0 0
Malate-aspartate shuttle R-HSA-9856872 5.469931e-01 0.262 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.469931e-01 0.262 0 0
HDL assembly R-HSA-8963896 5.469931e-01 0.262 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.469931e-01 0.262 0 0
Zinc transporters R-HSA-435354 5.469931e-01 0.262 0 0
RUNX2 regulates bone development R-HSA-8941326 5.639078e-01 0.249 0 0
Triglyceride catabolism R-HSA-163560 5.639078e-01 0.249 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.639078e-01 0.249 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.639078e-01 0.249 0 0
RNA Polymerase III Transcription R-HSA-74158 5.639078e-01 0.249 0 0
Extension of Telomeres R-HSA-180786 5.650045e-01 0.248 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.650045e-01 0.248 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.650045e-01 0.248 0 0
SLC transporter disorders R-HSA-5619102 5.664658e-01 0.247 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.665009e-01 0.247 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.665009e-01 0.247 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.665009e-01 0.247 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.665009e-01 0.247 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.665009e-01 0.247 0 0
Other semaphorin interactions R-HSA-416700 5.665009e-01 0.247 0 0
Neuronal System R-HSA-112316 5.737310e-01 0.241 0 0
RAB geranylgeranylation R-HSA-8873719 5.749812e-01 0.240 0 0
tRNA Aminoacylation R-HSA-379724 5.749812e-01 0.240 0 0
Metabolism of polyamines R-HSA-351202 5.749812e-01 0.240 0 0
Cleavage of the damaged purine R-HSA-110331 5.763454e-01 0.239 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.843098e-01 0.233 0 0
Aquaporin-mediated transport R-HSA-445717 5.848138e-01 0.233 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.848138e-01 0.233 0 0
Phosphorylation of the APC/C R-HSA-176412 5.851697e-01 0.233 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.851697e-01 0.233 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 5.851697e-01 0.233 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.851697e-01 0.233 0 0
Prolonged ERK activation events R-HSA-169893 5.851697e-01 0.233 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.851697e-01 0.233 0 0
Killing mechanisms R-HSA-9664420 5.851697e-01 0.233 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.851697e-01 0.233 0 0
Fructose catabolism R-HSA-70350 5.851697e-01 0.233 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.851697e-01 0.233 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.851697e-01 0.233 0 0
Attachment and Entry R-HSA-9678110 5.851697e-01 0.233 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 5.866026e-01 0.232 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.885217e-01 0.230 0 0
Depurination R-HSA-73927 5.885217e-01 0.230 0 0
Elastic fibre formation R-HSA-1566948 5.885217e-01 0.230 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.885217e-01 0.230 0 0
Mitochondrial protein import R-HSA-1268020 5.945002e-01 0.226 0 0
Heme signaling R-HSA-9707616 5.945002e-01 0.226 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.004361e-01 0.222 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.004361e-01 0.222 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.030356e-01 0.220 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.030356e-01 0.220 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.030356e-01 0.220 0 0
Fibronectin matrix formation R-HSA-1566977 6.030356e-01 0.220 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.030356e-01 0.220 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.030356e-01 0.220 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.030356e-01 0.220 0 0
Disorders of Developmental Biology R-HSA-9675151 6.030356e-01 0.220 0 0
Potential therapeutics for SARS R-HSA-9679191 6.071638e-01 0.217 0 0
Post-translational protein modification R-HSA-597592 6.086237e-01 0.216 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.120887e-01 0.213 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.120887e-01 0.213 0 0
Diseases of Immune System R-HSA-5260271 6.120887e-01 0.213 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.120887e-01 0.213 0 0
Generation of second messenger molecules R-HSA-202433 6.120887e-01 0.213 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 6.120887e-01 0.213 0 0
Interleukin-2 family signaling R-HSA-451927 6.120887e-01 0.213 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.201332e-01 0.208 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.201332e-01 0.208 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.201332e-01 0.208 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.201332e-01 0.208 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 6.201332e-01 0.208 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.201332e-01 0.208 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.201332e-01 0.208 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 6.234798e-01 0.205 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.234798e-01 0.205 0 0
Base Excision Repair R-HSA-73884 6.329890e-01 0.199 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.346103e-01 0.197 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.346103e-01 0.197 0 0
GAB1 signalosome R-HSA-180292 6.364953e-01 0.196 0 0
PKA activation R-HSA-163615 6.364953e-01 0.196 0 0
Apoptotic factor-mediated response R-HSA-111471 6.364953e-01 0.196 0 0
Mismatch Repair R-HSA-5358508 6.364953e-01 0.196 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.454816e-01 0.190 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.454816e-01 0.190 0 0
Depyrimidination R-HSA-73928 6.454816e-01 0.190 0 0
Conjugation of carboxylic acids R-HSA-159424 6.521536e-01 0.186 0 0
Amino Acid conjugation R-HSA-156587 6.521536e-01 0.186 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.521536e-01 0.186 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.521536e-01 0.186 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.633255e-01 0.178 0 0
FCGR activation R-HSA-2029481 6.633255e-01 0.178 0 0
DAP12 interactions R-HSA-2172127 6.664536e-01 0.176 0 0
COPII-mediated vesicle transport R-HSA-204005 6.665627e-01 0.176 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.671383e-01 0.176 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.671383e-01 0.176 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.671383e-01 0.176 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 6.671383e-01 0.176 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.671383e-01 0.176 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.671383e-01 0.176 0 0
Collagen formation R-HSA-1474290 6.706373e-01 0.174 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.765267e-01 0.170 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.765586e-01 0.170 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.814784e-01 0.167 0 0
Lagging Strand Synthesis R-HSA-69186 6.814784e-01 0.167 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.814784e-01 0.167 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.814784e-01 0.167 0 0
ERK/MAPK targets R-HSA-198753 6.814784e-01 0.167 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.814784e-01 0.167 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.814784e-01 0.167 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 6.830448e-01 0.166 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.864129e-01 0.163 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.864129e-01 0.163 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.864129e-01 0.163 0 0
Cell surface interactions at the vascular wall R-HSA-202733 6.929870e-01 0.159 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.952015e-01 0.158 0 0
Androgen biosynthesis R-HSA-193048 6.952015e-01 0.158 0 0
Attachment and Entry R-HSA-9694614 6.952015e-01 0.158 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.972031e-01 0.157 0 0
Metal ion SLC transporters R-HSA-425410 7.053811e-01 0.152 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.055413e-01 0.151 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.083342e-01 0.150 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.083342e-01 0.150 0 0
Fructose metabolism R-HSA-5652084 7.083342e-01 0.150 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.209018e-01 0.142 0 0
Formation of the ureteric bud R-HSA-9830674 7.209018e-01 0.142 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.215718e-01 0.142 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.233834e-01 0.141 0 0
The phototransduction cascade R-HSA-2514856 7.320310e-01 0.135 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.329286e-01 0.135 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.329286e-01 0.135 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.329286e-01 0.135 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.329286e-01 0.135 0 0
Complex III assembly R-HSA-9865881 7.329286e-01 0.135 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.329286e-01 0.135 0 0
Interleukin-6 family signaling R-HSA-6783589 7.329286e-01 0.135 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.359262e-01 0.133 0 0
Neurexins and neuroligins R-HSA-6794361 7.404478e-01 0.131 0 0
TGFBR3 expression R-HSA-9839394 7.444378e-01 0.128 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.444378e-01 0.128 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.444378e-01 0.128 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.486376e-01 0.126 0 0
Nucleotide biosynthesis R-HSA-8956320 7.486376e-01 0.126 0 0
Metabolism of amino acids and derivatives R-HSA-71291 7.506842e-01 0.125 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.554517e-01 0.122 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.554517e-01 0.122 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.554517e-01 0.122 0 0
Urea cycle R-HSA-70635 7.554517e-01 0.122 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.554517e-01 0.122 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.566043e-01 0.121 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.659917e-01 0.116 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.659917e-01 0.116 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.760779e-01 0.110 0 0
Pyrimidine salvage R-HSA-73614 7.760779e-01 0.110 0 0
Synthesis of PA R-HSA-1483166 7.792065e-01 0.108 0 0
Dectin-2 family R-HSA-5621480 7.792065e-01 0.108 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.815841e-01 0.107 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.875447e-01 0.104 0 0
Triglyceride metabolism R-HSA-8979227 7.932343e-01 0.101 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.938873e-01 0.100 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.949666e-01 0.100 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.999487e-01 0.097 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.087325e-01 0.092 0 0
Neurotransmitter release cycle R-HSA-112310 8.100508e-01 0.091 0 0
G0 and Early G1 R-HSA-1538133 8.122641e-01 0.090 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.183527e-01 0.087 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.189448e-01 0.087 0 0
G-protein beta:gamma signalling R-HSA-397795 8.203584e-01 0.086 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.203584e-01 0.086 0 0
CD22 mediated BCR regulation R-HSA-5690714 8.249085e-01 0.084 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.281041e-01 0.082 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.281041e-01 0.082 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.281041e-01 0.082 0 0
eNOS activation R-HSA-203615 8.355164e-01 0.078 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 8.355164e-01 0.078 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.355164e-01 0.078 0 0
Signal amplification R-HSA-392518 8.355164e-01 0.078 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.363088e-01 0.078 0 0
Signalling to ERKs R-HSA-187687 8.426094e-01 0.074 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.426094e-01 0.074 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.426094e-01 0.074 0 0
G alpha (i) signalling events R-HSA-418594 8.441553e-01 0.074 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 8.470339e-01 0.072 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.493970e-01 0.071 0 0
Formation of the cornified envelope R-HSA-6809371 8.558501e-01 0.068 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.558923e-01 0.068 0 0
Collagen chain trimerization R-HSA-8948216 8.558923e-01 0.068 0 0
Metabolism of folate and pterines R-HSA-196757 8.558923e-01 0.068 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.571164e-01 0.067 0 0
ECM proteoglycans R-HSA-3000178 8.619267e-01 0.065 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.621078e-01 0.064 0 0
Ca2+ pathway R-HSA-4086398 8.711052e-01 0.060 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 8.737472e-01 0.059 0 0
Maturation of spike protein R-HSA-9694548 8.791936e-01 0.056 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.791936e-01 0.056 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 8.797195e-01 0.056 0 0
Transport of small molecules R-HSA-382551 8.821283e-01 0.054 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.844054e-01 0.053 0 0
Interleukin-10 signaling R-HSA-6783783 8.916482e-01 0.050 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 8.941649e-01 0.049 0 0
Pyrimidine catabolism R-HSA-73621 8.941649e-01 0.049 0 0
Surfactant metabolism R-HSA-5683826 8.987317e-01 0.046 0 0
Signaling by TGFBR3 R-HSA-9839373 9.072832e-01 0.042 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.112846e-01 0.040 0 0
Bacterial Infection Pathways R-HSA-9824439 9.136876e-01 0.039 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.187775e-01 0.037 0 0
G alpha (s) signalling events R-HSA-418555 9.201359e-01 0.036 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.204983e-01 0.036 0 0
PI3K Cascade R-HSA-109704 9.222835e-01 0.035 0 0
Complex IV assembly R-HSA-9864848 9.256383e-01 0.034 0 0
G alpha (q) signalling events R-HSA-416476 9.314200e-01 0.031 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.316791e-01 0.031 0 0
Metabolism of nucleotides R-HSA-15869 9.328229e-01 0.030 0 0
Gastrulation R-HSA-9758941 9.353938e-01 0.029 0 0
IRS-mediated signalling R-HSA-112399 9.429391e-01 0.026 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.454033e-01 0.024 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.454033e-01 0.024 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.488715e-01 0.023 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.521765e-01 0.021 0 0
Nucleotide salvage R-HSA-8956321 9.521765e-01 0.021 0 0
Collagen degradation R-HSA-1442490 9.521765e-01 0.021 0 0
GPCR downstream signalling R-HSA-388396 9.546672e-01 0.020 0 0
Complex I biogenesis R-HSA-6799198 9.562191e-01 0.019 0 0
Adipogenesis R-HSA-9843745 9.564416e-01 0.019 0 0
Insulin receptor signalling cascade R-HSA-74751 9.581105e-01 0.019 0 0
IGF1R signaling cascade R-HSA-2428924 9.581105e-01 0.019 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.599203e-01 0.018 0 0
Kidney development R-HSA-9830369 9.633091e-01 0.016 0 0
Metabolism of steroid hormones R-HSA-196071 9.633091e-01 0.016 0 0
Metabolism of cofactors R-HSA-8978934 9.692522e-01 0.014 0 0
Purine catabolism R-HSA-74259 9.705813e-01 0.013 0 0
Aspirin ADME R-HSA-9749641 9.718529e-01 0.012 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.774336e-01 0.010 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.819090e-01 0.008 0 0
Nucleotide catabolism R-HSA-8956319 9.872192e-01 0.006 0 0
Signaling by GPCR R-HSA-372790 9.886534e-01 0.005 0 0
Signaling by Insulin receptor R-HSA-74752 9.888787e-01 0.005 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.890382e-01 0.005 0 0
Keratinization R-HSA-6805567 9.895551e-01 0.005 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.910863e-01 0.004 0 0
Respiratory electron transport R-HSA-611105 9.920959e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.921948e-01 0.003 0 0
Peptide ligand-binding receptors R-HSA-375276 9.940525e-01 0.003 0 0
Visual phototransduction R-HSA-2187338 9.943276e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.954124e-01 0.002 0 0
Antimicrobial peptides R-HSA-6803157 9.956112e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.966358e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.966358e-01 0.001 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.988069e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.992882e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.993633e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.994040e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.994128e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.994547e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.995227e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.995633e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.997629e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.998121e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999158e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999227e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999736e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999873e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999893e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999897e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999936e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999956e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999982e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999989e-01 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways