PRKX

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00562 S664 Sugiyama PITPNM1 DRES9 NIR2 PITPNM SQNSLQAAPATTSSWEPRRAstAFCPPAASSEAPDGPSSTA
O14579 S99 Sugiyama COPE PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14618 S267 Sugiyama CCS DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15143 S328 Sugiyama ARPC1B ARC41 KAssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTT
O43318 S439 Sugiyama MAP3K7 TAK1 GNILDVPEIVISGNGQPRRRsIQDLtVtGTEPGQVssRsss
O43541 S435 GPS6|EPSD|PSP SMAD6 MADH6 PTLDAPGGRALVVRKVPPGYsIKVFDFERSGLQHAPEPDAA
O43615 S180 Sugiyama TIMM44 MIMT44 TIM44 AESVSKGGEKLGRTAAFRALsQGVEsVKKEIDDsVLGQtGP
O43847 S94 Sugiyama NRDC NRD1 ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR
O43930 S81 Sugiyama PRKY GRVHLVKEKTAKHFFALKVMsIPDVIRRKQEQHVHNEKSVL
O60293 S42 Sugiyama ZFC3H1 CCDC131 KIAA0546 PSRC2 LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60343 S588 Sugiyama TBC1D4 AS160 KIAA0603 tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75348 S68 Sugiyama ATP6V1G1 ATP6G ATP6G1 ATP6J RLQREKEFKAKEAAALGsRGsCstEVEKETQEKMTILQtyF
O75390 S97 Sugiyama CS GLVyEtsVLDPDEGIRFRGFsIPECQKLLPKAKGGEEPLPE
O75665 S899 Sugiyama OFD1 CXorf5 EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O94915 S1957 Sugiyama FRYL AF4P12 KIAA0826 ARsNsLRLsLIGDRRGDRRRsNtLDIMDGRINHsssLARtR
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95613 S1814 Sugiyama PCNT KIAA0402 PCNT2 AALEAKEALSRLLADQERRHsQALEALQQRLQGAEEAAELQ
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P01023 S273 Sugiyama A2M CPAMD5 FWP007 LYTYGKPVPGHVTVSICRKYsDAsDCHGEDSQAFCEKFSGQ
P01023 S276 Sugiyama A2M CPAMD5 FWP007 YGKPVPGHVTVSICRKYsDAsDCHGEDSQAFCEKFSGQLNS
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07900 S623 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII
P08238 S452 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P09972 S45 Sugiyama ALDOC ALDC APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0C0L4 S1567 Sugiyama C4A CO4 CPAMD2 GLVQPASATLYDYYNPERRCsVFYGAPSKSRLLATLCSAEV
P0C0L5 S1567 Sugiyama C4B CO4 CPAMD3; C4B_2 GLVQPASATLYDYYNPERRCsVFYGAPSKSRLLATLCSAEV
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11586 S490 Sugiyama MTHFD1 MTHFC MTHFD QTDKALFNRLVPSVNGVRRFsDIQIRRLKRLGIEKTDPTTL
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P15880 S190 Sugiyama RPS2 RPS4 WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P16333 S85 Sugiyama NCK1 NCK ASIVKNLKDTLGIGKVKRKPsVPDsAsPADDsFVDPGERLy
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17812 S573 Sugiyama CTPS1 CTPS HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P18615 S131 Sugiyama NELFE RD RDBP QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19174 S1233 Sugiyama PLCG1 PLC1 PAKENGDLsPFsGtsLRERGsDASGQLFHGRAREGsFEsRy
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27448 S42 Sugiyama MARK3 CTAK1 EMK2 GDGRQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTI
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P29401 S190 Sugiyama TKT ASIYKLDNLVAILDINRLGQsDPAPLQHQMDIyQKRCEAFG
P29401 S305 Sugiyama TKT LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL
P29401 S473 Sugiyama TKT AtEKAVELAANTKGICFIRTsRPENAIIyNNNEDFQVGQAK
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P32119 S112 Sugiyama PRDX2 NKEFB TDPX1 KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818 S718 Sugiyama USP8 KIAA0055 UBPY AKPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtP
P41091 S107 Sugiyama EIF2S3 EIF2G KIYKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLV
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S648 Sugiyama MKI67 RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49207 S12 Sugiyama RPL34 _________MVQRLTYRRRLsYNtASNKTRLSRTPGNRIVy
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49588 S237 Sugiyama AARS1 AARS LVFIQYNREADGILKPLPKKsIDtGMGLERLVsVLQNKMSN
P49736 S229 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51817 S81 Sugiyama PRKX PKX1 GRVHLVKEKTAKHFFALKVMsIPDVIRLKQEQHVHNEKSVL
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52732 S36 Sugiyama KIF11 EG5 KNSL1 TRIP5 GKNIQVVVRCRPFNLAERKAsAHsIVECDPVRKEVSVRTGG
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54105 S102 Sugiyama CLNS1A CLCI ICLN VNAKFEEEsKEPVADEEEEDsDDDVEPITEFRFVPSDKSAL
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60174 S21 Sugiyama TPI1 TPI MAPSRKFFVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVV
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P63146 S142 Sugiyama UBE2B RAD6B UBCH1 ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P98161 S4166 GPS6|SIGNOR|EPSD|PSP PKD1 VKEFRHKVRFEGMEPLPSRSsRGsKVSPDVPPPSAGSDASH
Q00610 S146 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q00610 S147 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 VYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLLL
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q04917 S145 Sugiyama YWHAH YWHA1 KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q08211 S449 Sugiyama DHX9 DDX9 LKP NDH2 FIQNDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSC
Q08211 S452 Sugiyama DHX9 DDX9 LKP NDH2 NDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSCGYS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09161 S22 Sugiyama NCBP1 CBP80 NCBP SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q12789 S1868 Sugiyama GTF3C1 EGQAPPsHsPRGTKRRAsWAsENGEtDAEGTQMtPAKRPAL
Q12982 S114 Sugiyama BNIP2 NIP2 EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13247 S301 Sugiyama SRSF6 SFRS6 SRP55 PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13501 S24 Sugiyama SQSTM1 ORCA OSIL LTVKAYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPC
Q13501 S28 Sugiyama SQSTM1 ORCA OSIL AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14157 S852 Sugiyama UBAP2L KIAA0144 NICE4 LDyysIPFPtPttPLtGRDGsLAsNPysGDLtKFGRGDASS
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14738 S573 Sugiyama PPP2R5D TEAVQMLKDIKKEKVLLRRKsELPQDVyTIKALEAHKRAEE
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15149 S4386 Sugiyama PLEC PLEC1 ItEFADMLsGNAGGFRsRsssVGssssyPIsPAVsRtQLAs
Q15785 S93 Sugiyama TOMM34 URCC3 DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q32MZ4 S120 Sugiyama LRRFIP1 GCF2 TRIP MPGLSAAtLAsLGGtssRRGsGDtsISIDTEASIREIKELN
Q32MZ4 S124 Sugiyama LRRFIP1 GCF2 TRIP SAAtLAsLGGtssRRGsGDtsISIDTEASIREIKELNELKD
Q3KQU3 S112 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5T0N5 S488 Sugiyama FNBP1L C1orf39 TOCA1 NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T1M5 S1162 Sugiyama FKBP15 KIAA0674 EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5T2R2 S355 Sugiyama PDSS1 DPS1 TPRT PVLFACQQFPEMNAMIMRRFsLPGDVDRARQYVLQSDGVQQ
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6ZN18 S206 Sugiyama AEBP2 DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q7Z417 S655 Sugiyama NUFIP2 KIAA1321 PIG1 LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q7Z4V5 S370 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 KERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGRG
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q7Z5L9 S455 Sugiyama IRF2BP2 AGGSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVG
Q7Z5L9 S457 Sugiyama IRF2BP2 GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TEW0 S720 Sugiyama PARD3 PAR3 PAR3A ELPIETALDDRERRIsHsLysGIEGLDEsPsRNAALsRIMG
Q92597 S330 Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92766 S1167 Sugiyama RREB1 FINB AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q96EP0 S466 Sugiyama RNF31 ZIBRA RPYAssLEKGPPKPGPPRRLsAPLPSsCGDPEKQRQDKMRE
Q96G46 S236 Sugiyama DUS3L QQLRKREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPR
Q96PK6 S618 Sugiyama RBM14 SIP MSKRYGSDRRLAELsDYRRLsEsQLsFRRsPtKSSLDYRRL
Q99584 S32 Sugiyama S100A13 SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BRA2 S41 Sugiyama TXNDC17 TXNL5 QHNGKTIFAyFTGSKDAGGKsWCPDCVQAEPVVREGLKHIS
Q9BTC0 S1456 Sugiyama DIDO1 C20orf158 DATF1 KIAA0333 EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9H0B6 S428 Sugiyama KLC2 NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H0D6 S678 Sugiyama XRN2 LRAALEEVyPDLTPEEtRRNsLGGDVLFVGKHHPLHDFILE
Q9H2G2 S340 Sugiyama SLK KIAA0204 STK2 EEDEEEEtENsLPIPAsKRAssDLsIAssEEDKLsQNACIL
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9H7E9 T40 Sugiyama C8orf33 PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9P0K1 S834 Sugiyama ADAM22 MDC2 RIPDTKHISDICENGRPRsNsWQGNLGGNKKKIRGKRFRPR
Q9P265 S203 Sugiyama DIP2B KIAA1463 stsssASSTLSHGEVKGtsGsLADVFANtRIENFSAPPDVT
Q9UBP6 S27 Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2 S327 Sugiyama NDRG3 KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 S333 Sugiyama NDRG3 MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2 T329 Sugiyama NDRG3 FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UHD1 S200 Sugiyama CHORDC1 CHP1 SGVPIFHEGMKYWSCCRRKtsDFNtFLAQEGCtKGKHMWTK
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9UNH7 S316 Sugiyama SNX6 LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35 S1539 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35 S854 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFE
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin modifying enzymes R-HSA-3247509 2.836505e-07 6.547 0 0
Chromatin organization R-HSA-4839726 7.594410e-07 6.120 0 0
NRAGE signals death through JNK R-HSA-193648 6.562878e-06 5.183 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.261620e-06 5.139 0 0
G alpha (12/13) signalling events R-HSA-416482 2.088726e-05 4.680 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.632850e-05 4.580 0 0
Gene expression (Transcription) R-HSA-74160 2.483822e-05 4.605 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.212803e-05 4.375 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.647974e-05 4.177 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.854993e-05 4.006 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.047670e-04 3.980 0 0
Axon guidance R-HSA-422475 1.143028e-04 3.942 0 0
mRNA Splicing R-HSA-72172 1.451507e-04 3.838 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.701871e-04 3.769 0 0
Apoptotic execution phase R-HSA-75153 2.441782e-04 3.612 0 0
mRNA 3'-end processing R-HSA-72187 2.647094e-04 3.577 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.835166e-04 3.547 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.330239e-04 3.478 0 0
Cell Cycle R-HSA-1640170 4.552694e-04 3.342 0 0
Nervous system development R-HSA-9675108 5.501770e-04 3.259 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.463601e-04 3.127 0 0
RNA Polymerase II Transcription R-HSA-73857 7.734208e-04 3.112 0 0
Death Receptor Signaling R-HSA-73887 8.127871e-04 3.090 0 0
Signal Transduction R-HSA-162582 8.245656e-04 3.084 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.132062e-04 3.090 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.845928e-04 3.053 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.012137e-03 2.995 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.031107e-03 2.987 0 0
Kinesins R-HSA-983189 1.039623e-03 2.983 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.088469e-03 2.963 0 0
Activation of RAC1 R-HSA-428540 1.150111e-03 2.939 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.138139e-03 2.944 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.174477e-03 2.930 0 0
Regulation of TP53 Activity R-HSA-5633007 1.406026e-03 2.852 0 0
Signaling by ROBO receptors R-HSA-376176 1.447791e-03 2.839 0 0
RAF activation R-HSA-5673000 1.532185e-03 2.815 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.607322e-03 2.794 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.163849e-03 2.665 0 0
RET signaling R-HSA-8853659 2.254837e-03 2.647 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.284155e-03 2.641 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.314794e-03 2.635 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.708800e-03 2.567 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.622257e-03 2.581 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.622257e-03 2.581 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.690492e-03 2.570 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.030634e-03 2.518 0 0
Cell Cycle Checkpoints R-HSA-69620 3.087285e-03 2.510 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.228654e-03 2.374 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.342547e-03 2.272 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.190254e-03 2.285 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.190254e-03 2.285 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.190254e-03 2.285 0 0
Signaling by RAS mutants R-HSA-6802949 5.190254e-03 2.285 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.341593e-03 2.272 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.321515e-03 2.274 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.871987e-03 2.312 0 0
HDMs demethylate histones R-HSA-3214842 5.939228e-03 2.226 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.363945e-03 2.196 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.216455e-03 2.206 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.510752e-03 2.186 1 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.220524e-03 2.141 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.220524e-03 2.141 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.220524e-03 2.141 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.220524e-03 2.141 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.220524e-03 2.141 0 0
HATs acetylate histones R-HSA-3214847 6.926243e-03 2.160 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.617467e-03 2.118 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.211843e-03 2.086 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.211843e-03 2.086 0 0
Specification of primordial germ cells R-HSA-9827857 9.073647e-03 2.042 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.534138e-03 2.021 0 0
Netrin-1 signaling R-HSA-373752 9.630044e-03 2.016 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.034488e-02 1.985 0 0
Mitotic Prometaphase R-HSA-68877 1.037435e-02 1.984 0 0
HIV elongation arrest and recovery R-HSA-167287 1.042255e-02 1.982 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.042255e-02 1.982 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.135110e-02 1.945 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.233259e-02 1.909 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.241192e-02 1.906 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.401589e-02 1.853 0 0
Rap1 signalling R-HSA-392517 1.401589e-02 1.853 0 0
DCC mediated attractive signaling R-HSA-418885 1.566270e-02 1.805 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.566270e-02 1.805 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.539002e-02 1.813 0 0
Generic Transcription Pathway R-HSA-212436 1.491204e-02 1.826 0 0
Signaling by APC mutants R-HSA-4839744 1.654290e-02 1.781 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.654290e-02 1.781 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.654290e-02 1.781 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.654290e-02 1.781 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.741827e-02 1.759 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.710022e-02 1.767 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.885163e-02 1.725 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.885163e-02 1.725 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.885163e-02 1.725 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.885163e-02 1.725 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.885163e-02 1.725 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.878984e-02 1.726 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.809406e-02 1.742 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.854754e-02 1.732 0 0
Cell Cycle, Mitotic R-HSA-69278 1.878926e-02 1.726 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.956798e-02 1.708 0 0
Regulation of PTEN localization R-HSA-8948747 2.151093e-02 1.667 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.099399e-02 1.678 0 0
Signaling by AXIN mutants R-HSA-4839735 2.149773e-02 1.668 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.149773e-02 1.668 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.099399e-02 1.678 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.553695e-02 1.593 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.553695e-02 1.593 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.409551e-02 1.618 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.409551e-02 1.618 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.409551e-02 1.618 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.535977e-02 1.596 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.409551e-02 1.618 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.553695e-02 1.593 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.553695e-02 1.593 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.449646e-02 1.611 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.574214e-02 1.589 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.592735e-02 1.586 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.777504e-02 1.556 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.777504e-02 1.556 0 0
M Phase R-HSA-68886 2.832280e-02 1.548 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.916510e-02 1.535 0 0
Centrosome maturation R-HSA-380287 3.040640e-02 1.517 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.909358e-02 1.536 0 0
PLC beta mediated events R-HSA-112043 3.166395e-02 1.499 1 0
Metabolism of RNA R-HSA-8953854 3.122570e-02 1.505 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.908004e-02 1.536 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.352996e-02 1.475 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.379964e-02 1.471 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.488799e-02 1.457 0 0
MAP2K and MAPK activation R-HSA-5674135 3.524656e-02 1.453 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.761706e-02 1.425 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.554238e-02 1.449 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.826555e-02 1.417 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.826555e-02 1.417 0 0
Calmodulin induced events R-HSA-111933 3.879536e-02 1.411 1 0
CaM pathway R-HSA-111997 3.879536e-02 1.411 1 0
Semaphorin interactions R-HSA-373755 3.826555e-02 1.417 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.165869e-02 1.380 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.893292e-02 1.310 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.893292e-02 1.310 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.596180e-02 1.338 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.596180e-02 1.338 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.815933e-02 1.317 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.713829e-02 1.327 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.841471e-02 1.315 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.425966e-02 1.354 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.738218e-02 1.324 0 0
Signaling by ALK in cancer R-HSA-9700206 4.738218e-02 1.324 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.890648e-02 1.311 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.841471e-02 1.315 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.898586e-02 1.310 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.211128e-02 1.283 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.211128e-02 1.283 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.211128e-02 1.283 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.212699e-02 1.283 0 0
TRP channels R-HSA-3295583 5.269819e-02 1.278 0 0
DAG and IP3 signaling R-HSA-1489509 5.415138e-02 1.266 1 0
DNA Double Strand Break Response R-HSA-5693606 5.428191e-02 1.265 0 0
G-protein mediated events R-HSA-112040 5.428191e-02 1.265 1 0
Nuclear RNA decay R-HSA-9930044 5.435992e-02 1.265 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.435992e-02 1.265 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.468661e-02 1.262 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.468661e-02 1.262 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 6.589246e-02 1.181 0 0
Regulation of cortical dendrite branching R-HSA-8985801 6.589246e-02 1.181 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.104815e-02 1.214 0 0
HIV Transcription Elongation R-HSA-167169 6.080163e-02 1.216 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.080163e-02 1.216 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.890592e-02 1.230 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.928278e-02 1.227 0 0
Regulation of TP53 Expression R-HSA-6804754 6.589246e-02 1.181 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.007805e-02 1.221 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.794147e-02 1.168 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.823004e-02 1.166 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.823004e-02 1.166 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.889041e-02 1.162 0 0
Muscle contraction R-HSA-397014 7.009762e-02 1.154 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.069082e-02 1.151 0 0
Cellular Senescence R-HSA-2559583 7.125520e-02 1.147 0 0
Mitotic Prophase R-HSA-68875 7.317191e-02 1.136 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.334386e-02 1.135 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.518240e-02 1.124 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.645708e-02 1.117 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.645708e-02 1.117 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 8.778134e-02 1.057 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.778134e-02 1.057 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 8.778134e-02 1.057 0 0
TRIF-mediated programmed cell death R-HSA-2562578 8.778134e-02 1.057 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.463641e-02 1.072 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.699179e-02 1.061 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.629375e-02 1.064 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.162528e-02 1.088 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.694320e-02 1.061 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.628265e-02 1.064 0 0
Mitotic Anaphase R-HSA-68882 8.285945e-02 1.082 0 0
Ca-dependent events R-HSA-111996 8.168196e-02 1.088 1 0
Signaling by Hippo R-HSA-2028269 8.226409e-02 1.085 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 8.541025e-02 1.068 0 0
Repression of WNT target genes R-HSA-4641265 8.782395e-02 1.056 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 9.477593e-02 1.023 0 0
Polo-like kinase mediated events R-HSA-156711 9.477593e-02 1.023 0 0
Nephron development R-HSA-9831926 9.477593e-02 1.023 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 9.879373e-02 1.005 0 0
PDGFR mutants bind TKIs R-HSA-9674428 9.879373e-02 1.005 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 9.879373e-02 1.005 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.879373e-02 1.005 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 9.879373e-02 1.005 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 9.879373e-02 1.005 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 9.879373e-02 1.005 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 9.879373e-02 1.005 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 9.633337e-02 1.016 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.085815e-01 0.964 0 0
Type I hemidesmosome assembly R-HSA-446107 1.085815e-01 0.964 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.085815e-01 0.964 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 1.085815e-01 0.964 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.035677e-01 0.985 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.035677e-01 0.985 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.081959e-01 0.966 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.636414e-02 1.016 0 0
Deadenylation of mRNA R-HSA-429947 9.636414e-02 1.016 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.033459e-01 0.986 0 0
Transcription of the HIV genome R-HSA-167172 1.047037e-01 0.980 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.773372e-02 1.010 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.019281e-01 0.992 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.590619e-02 1.018 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.636414e-02 1.016 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.955749e-02 1.002 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.063954e-01 0.973 0 0
Kidney development R-HSA-9830369 9.762082e-02 1.010 0 0
Signaling by NTRKs R-HSA-166520 1.061318e-01 0.974 0 0
Signaling by ALK R-HSA-201556 1.115822e-01 0.952 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.154751e-01 0.938 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.164124e-01 0.934 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.169137e-01 0.932 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.878325e-01 0.726 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 1.878325e-01 0.726 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.878325e-01 0.726 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 1.878325e-01 0.726 0 0
Regulation of gap junction activity R-HSA-191650 1.298782e-01 0.886 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.298782e-01 0.886 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.298782e-01 0.886 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.680790e-01 0.572 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.680790e-01 0.572 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.680790e-01 0.572 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.680790e-01 0.572 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.680790e-01 0.572 0 0
Intestinal infectious diseases R-HSA-8942233 2.680790e-01 0.572 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.680790e-01 0.572 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.656173e-01 0.781 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.656173e-01 0.781 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.656173e-01 0.781 0 0
IRS activation R-HSA-74713 1.656173e-01 0.781 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.656173e-01 0.781 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.310702e-01 0.882 0 0
Signaling by MAPK mutants R-HSA-9652817 2.027905e-01 0.693 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.404010e-01 0.468 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.404010e-01 0.468 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.404010e-01 0.468 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.404010e-01 0.468 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.404010e-01 0.468 0 0
Potassium transport channels R-HSA-1296067 3.404010e-01 0.468 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.404010e-01 0.468 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.404010e-01 0.468 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.404010e-01 0.468 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.404010e-01 0.468 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.404010e-01 0.468 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.404010e-01 0.468 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.404010e-01 0.468 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 3.404010e-01 0.468 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.404010e-01 0.468 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.404010e-01 0.468 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.404010e-01 0.468 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.404010e-01 0.468 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.404010e-01 0.468 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.404010e-01 0.468 0 0
PI3K/AKT activation R-HSA-198203 1.550185e-01 0.810 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.204974e-01 0.919 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.801954e-01 0.744 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.385248e-01 0.858 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.224859e-01 0.912 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.224859e-01 0.912 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.224859e-01 0.912 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.224859e-01 0.912 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.224859e-01 0.912 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.575531e-01 0.803 0 0
Differentiation of T cells R-HSA-9945266 1.575531e-01 0.803 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.063743e-01 0.685 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.063743e-01 0.685 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 2.790228e-01 0.554 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.790228e-01 0.554 0 0
Netrin mediated repulsion signals R-HSA-418886 2.790228e-01 0.554 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 2.790228e-01 0.554 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.790228e-01 0.554 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.790228e-01 0.554 0 0
SOS-mediated signalling R-HSA-112412 2.790228e-01 0.554 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 2.790228e-01 0.554 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.790228e-01 0.554 0 0
Axonal growth stimulation R-HSA-209563 4.055806e-01 0.392 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.055806e-01 0.392 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.055806e-01 0.392 0 0
Invadopodia formation R-HSA-8941237 4.055806e-01 0.392 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.774799e-01 0.751 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.774799e-01 0.751 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.333364e-01 0.632 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.534911e-01 0.814 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.334008e-01 0.875 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.171349e-01 0.499 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.171349e-01 0.499 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.470549e-01 0.833 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.470549e-01 0.833 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.608744e-01 0.584 0 0
Ephrin signaling R-HSA-3928664 2.196018e-01 0.658 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.613117e-01 0.792 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.761355e-01 0.754 0 0
ALK mutants bind TKIs R-HSA-9700645 3.547578e-01 0.450 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.643228e-01 0.333 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.643228e-01 0.333 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.643228e-01 0.333 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 4.643228e-01 0.333 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.643228e-01 0.333 0 0
Trafficking of AMPA receptors R-HSA-399719 1.914875e-01 0.718 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.236397e-01 0.650 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.169160e-01 0.499 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.169160e-01 0.499 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.169160e-01 0.499 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.169160e-01 0.499 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.425100e-01 0.615 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.868397e-01 0.542 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.916162e-01 0.407 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.277203e-01 0.894 0 0
Striated Muscle Contraction R-HSA-390522 2.402964e-01 0.619 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.450760e-01 0.462 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.450760e-01 0.462 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.099146e-01 0.509 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.099146e-01 0.509 0 0
Meiotic synapsis R-HSA-1221632 1.900006e-01 0.721 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.573374e-01 0.589 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.415070e-01 0.849 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.845709e-01 0.734 0 0
HDACs deacetylate histones R-HSA-3214815 2.144361e-01 0.669 0 0
Phase 2 - plateau phase R-HSA-5576893 3.731260e-01 0.428 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.274940e-01 0.369 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.274940e-01 0.369 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.274940e-01 0.369 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.172631e-01 0.286 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.172631e-01 0.286 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.172631e-01 0.286 0 0
Defective F9 activation R-HSA-9673221 5.172631e-01 0.286 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.172631e-01 0.286 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.172631e-01 0.286 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.172631e-01 0.286 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.675536e-01 0.573 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.923047e-01 0.534 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.213592e-01 0.493 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.213592e-01 0.493 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.101399e-01 0.508 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.009333e-01 0.397 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.415913e-01 0.466 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.415913e-01 0.466 0 0
Metabolism of non-coding RNA R-HSA-194441 2.666224e-01 0.574 0 0
snRNP Assembly R-HSA-191859 2.666224e-01 0.574 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.622252e-01 0.335 0 0
ERKs are inactivated R-HSA-202670 4.622252e-01 0.335 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.045591e-01 0.516 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.283807e-01 0.368 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.283807e-01 0.368 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.267507e-01 0.644 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.267507e-01 0.644 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.822517e-01 0.418 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.872401e-01 0.542 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.645140e-01 0.438 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.553656e-01 0.342 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 4.956860e-01 0.305 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 4.956860e-01 0.305 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.649742e-01 0.248 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.649742e-01 0.248 0 0
PKB-mediated events R-HSA-109703 5.649742e-01 0.248 0 0
PDE3B signalling R-HSA-165160 5.649742e-01 0.248 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.649742e-01 0.248 0 0
Cam-PDE 1 activation R-HSA-111957 5.649742e-01 0.248 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.649742e-01 0.248 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.649742e-01 0.248 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.649742e-01 0.248 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.923304e-01 0.534 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.010585e-01 0.397 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.010585e-01 0.397 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.010585e-01 0.397 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.488504e-01 0.348 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.488504e-01 0.348 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.429089e-01 0.354 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.122171e-01 0.385 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.490532e-01 0.348 0 0
Translation initiation complex formation R-HSA-72649 4.655836e-01 0.332 0 0
STAT5 Activation R-HSA-9645135 6.079723e-01 0.216 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.079723e-01 0.216 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.079723e-01 0.216 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.079723e-01 0.216 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.982641e-01 0.303 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.087374e-01 0.294 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.792069e-01 0.319 0 0
FGFR2 alternative splicing R-HSA-6803529 5.571065e-01 0.254 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.571065e-01 0.254 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.275150e-01 0.278 0 0
Erythropoietin activates RAS R-HSA-9027284 5.877100e-01 0.231 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.877100e-01 0.231 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.877100e-01 0.231 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.767160e-01 0.239 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.929010e-01 0.227 0 0
Phosphorylation of the APC/C R-HSA-176412 6.154823e-01 0.211 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.467227e-01 0.189 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.467227e-01 0.189 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.467227e-01 0.189 0 0
Disinhibition of SNARE formation R-HSA-114516 6.467227e-01 0.189 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.041081e-01 0.219 0 0
Tight junction interactions R-HSA-420029 6.254412e-01 0.204 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.777032e-01 0.169 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.417949e-01 0.193 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 6.417949e-01 0.193 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 6.417949e-01 0.193 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.630160e-01 0.178 0 0
Nucleosome assembly R-HSA-774815 6.448832e-01 0.191 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.448832e-01 0.191 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.534241e-01 0.185 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 6.666650e-01 0.176 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.816449e-01 0.166 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.861664e-01 0.164 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.901207e-01 0.161 0 0
DNA methylation R-HSA-5334118 7.046918e-01 0.152 0 0
Late endosomal microautophagy R-HSA-9615710 7.046918e-01 0.152 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.138850e-01 0.503 0 0
RUNX2 regulates bone development R-HSA-8941326 1.652171e-01 0.782 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.020132e-01 0.299 0 0
EPH-Ephrin signaling R-HSA-2682334 1.184074e-01 0.927 0 0
RNA Polymerase III Transcription R-HSA-74158 2.923047e-01 0.534 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.470549e-01 0.833 0 0
Integrin signaling R-HSA-354192 2.236113e-01 0.651 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.822517e-01 0.418 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.260373e-01 0.371 0 0
Downstream signal transduction R-HSA-186763 1.914875e-01 0.718 0 0
Hedgehog 'off' state R-HSA-5610787 3.720824e-01 0.429 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.213592e-01 0.493 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.327273e-01 0.273 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.817998e-01 0.317 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.911912e-01 0.309 0 0
Telomere Extension By Telomerase R-HSA-171319 6.861664e-01 0.164 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.310702e-01 0.882 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.774799e-01 0.751 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.158730e-01 0.500 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.237553e-01 0.490 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.197559e-01 0.922 0 0
Aggrephagy R-HSA-9646399 5.400229e-01 0.268 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.277203e-01 0.894 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.817998e-01 0.317 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.972702e-01 0.527 0 0
Adipogenesis R-HSA-9843745 6.649796e-01 0.177 0 0
Frs2-mediated activation R-HSA-170968 2.608744e-01 0.584 0 0
MHC class II antigen presentation R-HSA-2132295 1.902406e-01 0.721 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.168009e-01 0.664 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.597455e-01 0.585 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.302830e-01 0.275 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.929010e-01 0.227 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.310702e-01 0.882 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.790228e-01 0.554 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.981988e-01 0.703 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.397783e-01 0.855 0 0
G-protein beta:gamma signalling R-HSA-397795 2.236113e-01 0.651 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.445069e-01 0.840 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.331560e-01 0.477 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.462883e-01 0.461 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.874220e-01 0.312 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.585132e-01 0.253 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.154823e-01 0.211 0 0
ESR-mediated signaling R-HSA-8939211 3.548726e-01 0.450 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.559697e-01 0.255 0 0
FOXO-mediated transcription R-HSA-9614085 5.922545e-01 0.227 0 0
Myogenesis R-HSA-525793 4.260373e-01 0.371 0 0
RNA Polymerase I Transcription R-HSA-73864 5.374860e-01 0.270 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 1.373720e-01 0.862 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.936514e-01 0.226 0 0
Dopamine receptors R-HSA-390651 1.298782e-01 0.886 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.298782e-01 0.886 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.680790e-01 0.572 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.027905e-01 0.693 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.333364e-01 0.632 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.547578e-01 0.450 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.547578e-01 0.450 0 0
DARPP-32 events R-HSA-180024 3.012718e-01 0.521 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.172631e-01 0.286 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.116326e-01 0.674 0 0
Separation of Sister Chromatids R-HSA-2467813 1.458944e-01 0.836 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.283807e-01 0.368 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.297528e-01 0.482 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.741726e-01 0.171 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.816449e-01 0.166 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.816449e-01 0.166 0 0
S Phase R-HSA-69242 6.533795e-01 0.185 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.451994e-01 0.610 0 0
Interleukin-2 signaling R-HSA-9020558 1.801954e-01 0.744 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.631242e-01 0.249 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.597485e-01 0.181 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.203823e-01 0.919 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.192098e-01 0.924 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.936514e-01 0.226 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.923304e-01 0.534 1 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.522496e-01 0.817 0 0
Long-term potentiation R-HSA-9620244 2.236397e-01 0.650 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.206427e-01 0.494 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.450409e-01 0.190 0 0
TNF signaling R-HSA-75893 3.502448e-01 0.456 0 0
Meiosis R-HSA-1500620 5.008876e-01 0.300 0 0
Prolonged ERK activation events R-HSA-169893 3.450760e-01 0.462 0 0
Calcineurin activates NFAT R-HSA-2025928 1.310702e-01 0.882 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.027905e-01 0.693 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.204974e-01 0.919 0 0
Ca2+ activated K+ channels R-HSA-1296052 2.790228e-01 0.554 0 0
Disorders of Developmental Biology R-HSA-9675151 1.774799e-01 0.751 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.774799e-01 0.751 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.171349e-01 0.499 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.171349e-01 0.499 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.171349e-01 0.499 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.608744e-01 0.584 1 1
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.236113e-01 0.651 0 0
Killing mechanisms R-HSA-9664420 3.450760e-01 0.462 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.450760e-01 0.462 0 0
Formation of the posterior neural plate R-HSA-9832991 4.274940e-01 0.369 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.622252e-01 0.335 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.192978e-01 0.377 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.123434e-01 0.505 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.192496e-01 0.285 0 0
PTK6 Expression R-HSA-8849473 6.467227e-01 0.189 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.448832e-01 0.191 0 0
IRS-mediated signalling R-HSA-112399 6.682407e-01 0.175 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.816449e-01 0.166 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.010585e-01 0.397 0 0
Homology Directed Repair R-HSA-5693538 3.037392e-01 0.517 0 0
Ion homeostasis R-HSA-5578775 1.360799e-01 0.866 0 0
Triglyceride catabolism R-HSA-163560 4.628404e-01 0.335 0 0
G1 Phase R-HSA-69236 4.555248e-01 0.341 0 0
Cyclin D associated events in G1 R-HSA-69231 4.555248e-01 0.341 0 0
Signaling by Hedgehog R-HSA-5358351 6.447446e-01 0.191 0 0
Signaling by VEGF R-HSA-194138 1.500586e-01 0.824 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.911912e-01 0.309 0 0
Neurexins and neuroligins R-HSA-6794361 2.896209e-01 0.538 0 0
mTORC1-mediated signalling R-HSA-166208 1.701005e-01 0.769 0 0
Signaling by WNT R-HSA-195721 2.153079e-01 0.667 0 0
MTOR signalling R-HSA-165159 1.548639e-01 0.810 0 0
Cilium Assembly R-HSA-5617833 2.048482e-01 0.689 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.025673e-01 0.395 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.324298e-01 0.364 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.779696e-01 0.750 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.298782e-01 0.886 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.027905e-01 0.693 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.027905e-01 0.693 0 0
Leukotriene receptors R-HSA-391906 2.407660e-01 0.618 0 0
Disorders of Nervous System Development R-HSA-9697154 2.333364e-01 0.632 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.333364e-01 0.632 0 0
Pervasive developmental disorders R-HSA-9005895 2.333364e-01 0.632 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.887941e-01 0.539 0 0
Lipophagy R-HSA-9613354 3.547578e-01 0.450 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.916162e-01 0.407 0 0
p38MAPK events R-HSA-171007 5.877100e-01 0.231 0 0
Signaling by SCF-KIT R-HSA-1433557 4.374650e-01 0.359 0 0
Regulated Necrosis R-HSA-5218859 6.754938e-01 0.170 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.822517e-01 0.418 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.254412e-01 0.204 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.987208e-01 0.702 0 0
Ub-specific processing proteases R-HSA-5689880 5.277220e-01 0.278 0 0
Neurofascin interactions R-HSA-447043 2.407660e-01 0.618 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.407660e-01 0.618 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.365533e-01 0.626 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.076079e-01 0.294 1 1
tRNA processing in the nucleus R-HSA-6784531 4.432069e-01 0.353 0 0
PTEN Regulation R-HSA-6807070 4.566360e-01 0.340 0 0
Formation of the ureteric bud R-HSA-9830674 5.807047e-01 0.236 0 0
Hedgehog 'on' state R-HSA-5632684 5.773590e-01 0.239 0 0
Post NMDA receptor activation events R-HSA-438064 1.338418e-01 0.873 1 0
Signaling by WNT in cancer R-HSA-4791275 2.073270e-01 0.683 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.379199e-01 0.195 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 2.790228e-01 0.554 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.777742e-01 0.238 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.154823e-01 0.211 0 0
G2/M Transition R-HSA-69275 1.794346e-01 0.746 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.221568e-01 0.492 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.197133e-01 0.208 1 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.384465e-01 0.269 0 0
Integration of energy metabolism R-HSA-163685 4.255373e-01 0.371 0 0
Triglyceride metabolism R-HSA-8979227 5.459918e-01 0.263 0 0
G1/S Transition R-HSA-69206 6.955790e-01 0.158 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.327273e-01 0.273 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.919250e-01 0.717 0 0
Specification of the neural plate border R-HSA-9834899 4.553656e-01 0.342 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.687787e-01 0.571 0 0
Signalling to ERKs R-HSA-187687 4.429089e-01 0.354 0 0
HIV Life Cycle R-HSA-162587 3.667984e-01 0.436 0 0
Developmental Biology R-HSA-1266738 4.431618e-01 0.353 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.142563e-01 0.289 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.064100e-01 0.217 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.822517e-01 0.418 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.825180e-01 0.166 0 0
G0 and Early G1 R-HSA-1538133 2.073270e-01 0.683 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.328723e-01 0.364 0 0
Interleukin-33 signaling R-HSA-9014843 3.404010e-01 0.468 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.404010e-01 0.468 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.055806e-01 0.392 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.055806e-01 0.392 0 0
MET interacts with TNS proteins R-HSA-8875513 4.055806e-01 0.392 0 0
Regulation of KIT signaling R-HSA-1433559 2.887941e-01 0.539 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.547578e-01 0.450 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.916162e-01 0.407 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.916162e-01 0.407 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.215177e-01 0.655 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.099146e-01 0.509 0 0
Notch-HLH transcription pathway R-HSA-350054 3.331560e-01 0.477 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.172631e-01 0.286 0 0
Reelin signalling pathway R-HSA-8866376 5.172631e-01 0.286 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.101399e-01 0.508 0 0
Smooth Muscle Contraction R-HSA-445355 3.045591e-01 0.516 0 0
PKA activation R-HSA-163615 4.283807e-01 0.368 0 0
PKA activation in glucagon signalling R-HSA-164378 4.283807e-01 0.368 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.283807e-01 0.368 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.645140e-01 0.438 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.221568e-01 0.492 0 0
Synthesis of PS R-HSA-1483101 5.649742e-01 0.248 0 0
Phosphorylation of Emi1 R-HSA-176417 5.649742e-01 0.248 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.649742e-01 0.248 0 0
Platelet calcium homeostasis R-HSA-418360 4.935330e-01 0.307 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.185181e-01 0.285 0 0
PI3K Cascade R-HSA-109704 5.599100e-01 0.252 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.975521e-01 0.224 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.154823e-01 0.211 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.467227e-01 0.189 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.171659e-01 0.210 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.171659e-01 0.210 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.859758e-01 0.164 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.448832e-01 0.191 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.944470e-01 0.158 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.666650e-01 0.176 0 0
Adrenoceptors R-HSA-390696 6.816449e-01 0.166 0 0
Regulation by c-FLIP R-HSA-3371378 6.816449e-01 0.166 0 0
Formation of annular gap junctions R-HSA-196025 6.816449e-01 0.166 0 0
MET promotes cell motility R-HSA-8875878 6.876577e-01 0.163 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.901207e-01 0.161 0 0
Membrane Trafficking R-HSA-199991 4.006134e-01 0.397 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.136889e-01 0.504 0 0
Cardiac conduction R-HSA-5576891 2.007062e-01 0.697 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.197559e-01 0.922 0 0
Ca2+ pathway R-HSA-4086398 3.371790e-01 0.472 0 0
Deubiquitination R-HSA-5688426 2.852686e-01 0.545 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.283807e-01 0.368 0 0
Cell junction organization R-HSA-446728 5.243638e-01 0.280 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.362894e-01 0.360 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.786555e-01 0.748 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.034905e-01 0.219 0 0
Opioid Signalling R-HSA-111885 2.238950e-01 0.650 1 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.385248e-01 0.858 0 0
Signaling by FGFR in disease R-HSA-1226099 6.187093e-01 0.209 0 0
UCH proteinases R-HSA-5689603 6.450409e-01 0.190 0 0
Cell-Cell communication R-HSA-1500931 3.235039e-01 0.490 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.707349e-01 0.768 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.236113e-01 0.651 0 0
Signaling by ERBB4 R-HSA-1236394 3.506996e-01 0.455 0 0
Interleukin-1 family signaling R-HSA-446652 5.972727e-01 0.224 0 0
Signal attenuation R-HSA-74749 3.916162e-01 0.407 0 0
Nuclear import of Rev protein R-HSA-180746 2.573374e-01 0.589 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.731260e-01 0.428 0 0
Rab regulation of trafficking R-HSA-9007101 4.957558e-01 0.305 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.614751e-01 0.251 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.754938e-01 0.170 0 0
Recycling pathway of L1 R-HSA-437239 6.762942e-01 0.170 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.861664e-01 0.164 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.046918e-01 0.152 0 0
FLT3 signaling in disease R-HSA-9682385 2.923047e-01 0.534 0 0
MAPK family signaling cascades R-HSA-5683057 2.353519e-01 0.628 0 0
Reproduction R-HSA-1474165 3.535410e-01 0.452 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.080331e-01 0.511 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.794455e-01 0.168 0 0
Macroautophagy R-HSA-1632852 6.728262e-01 0.172 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.385248e-01 0.858 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.608744e-01 0.584 0 0
Signal regulatory protein family interactions R-HSA-391160 2.887941e-01 0.539 0 0
Interleukin-1 processing R-HSA-448706 3.547578e-01 0.450 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.547578e-01 0.450 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.547578e-01 0.450 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.916162e-01 0.407 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.025673e-01 0.395 0 0
Signaling by LTK R-HSA-9842663 4.956860e-01 0.305 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.649742e-01 0.248 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.649742e-01 0.248 0 0
Syndecan interactions R-HSA-3000170 5.807047e-01 0.236 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.467227e-01 0.189 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.465418e-01 0.189 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.816449e-01 0.166 0 0
Programmed Cell Death R-HSA-5357801 1.941552e-01 0.712 0 0
Sensory processing of sound R-HSA-9659379 6.825180e-01 0.166 0 0
Diseases of programmed cell death R-HSA-9645723 5.536537e-01 0.257 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.122918e-01 0.673 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.642993e-01 0.439 0 0
G2/M Checkpoints R-HSA-69481 3.135066e-01 0.504 0 0
Regulation of BACH1 activity R-HSA-9708530 6.154823e-01 0.211 0 0
TGFBR3 expression R-HSA-9839394 6.254412e-01 0.204 0 0
Cardiogenesis R-HSA-9733709 5.777742e-01 0.238 0 0
Formation of the nephric duct R-HSA-9830364 2.236397e-01 0.650 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.327273e-01 0.273 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.283807e-01 0.368 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.431206e-01 0.265 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.431206e-01 0.265 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.682067e-01 0.245 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.236113e-01 0.651 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.465418e-01 0.189 0 0
Regulation of insulin secretion R-HSA-422356 4.611444e-01 0.336 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.972702e-01 0.527 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.680790e-01 0.572 0 0
DSCAM interactions R-HSA-376172 3.404010e-01 0.468 0 0
Synthesis of PI R-HSA-1483226 1.801954e-01 0.744 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.575531e-01 0.803 0 0
Alpha-defensins R-HSA-1462054 3.171349e-01 0.499 0 0
Sensory perception of sour taste R-HSA-9729555 4.643228e-01 0.333 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.360799e-01 0.866 0 0
LTC4-CYSLTR mediated IL4 production R-HSA-9664535 3.916162e-01 0.407 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 3.450760e-01 0.462 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.172631e-01 0.286 0 0
Interleukin-36 pathway R-HSA-9014826 5.172631e-01 0.286 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.649742e-01 0.248 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.079723e-01 0.216 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.807047e-01 0.236 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.495224e-01 0.187 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.608241e-01 0.180 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.816449e-01 0.166 0 0
Dimerization of procaspase-8 R-HSA-69416 6.816449e-01 0.166 0 0
PI Metabolism R-HSA-1483255 3.958271e-01 0.402 0 0
FLT3 Signaling R-HSA-9607240 3.827842e-01 0.417 0 0
NGF-stimulated transcription R-HSA-9031628 1.348614e-01 0.870 0 0
Apoptosis R-HSA-109581 1.347057e-01 0.871 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.645140e-01 0.438 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.655636e-01 0.437 0 0
Nephrin family interactions R-HSA-373753 2.640280e-01 0.578 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.425100e-01 0.615 0 0
Glycolysis R-HSA-70171 4.858481e-01 0.313 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.064100e-01 0.217 0 0
Signaling by PTK6 R-HSA-8848021 6.064100e-01 0.217 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.281492e-01 0.484 0 0
Protein hydroxylation R-HSA-9629569 4.817998e-01 0.317 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.666650e-01 0.176 0 0
L1CAM interactions R-HSA-373760 4.844137e-01 0.315 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.386806e-01 0.358 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.168009e-01 0.664 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.943361e-01 0.226 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.407660e-01 0.618 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.068354e-01 0.684 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.532395e-01 0.815 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.822517e-01 0.418 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.877100e-01 0.231 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.666650e-01 0.176 0 0
Signaling by NOTCH1 R-HSA-1980143 3.779604e-01 0.423 0 0
Signaling by EGFR R-HSA-177929 3.502448e-01 0.456 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.774799e-01 0.751 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.103117e-01 0.292 0 0
Neurodegenerative Diseases R-HSA-8863678 2.052380e-01 0.688 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.052380e-01 0.688 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.877100e-01 0.231 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.368651e-01 0.473 0 0
Formation of the anterior neural plate R-HSA-9823739 3.169160e-01 0.499 0 0
Diseases of DNA repair R-HSA-9675135 2.048832e-01 0.688 0 0
Co-stimulation by CD28 R-HSA-389356 2.320255e-01 0.634 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.788293e-01 0.168 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 2.790228e-01 0.554 0 0
Interleukin-18 signaling R-HSA-9012546 3.171349e-01 0.499 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.643228e-01 0.333 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.617826e-01 0.582 0 0
NrCAM interactions R-HSA-447038 5.172631e-01 0.286 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.822517e-01 0.418 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 5.649742e-01 0.248 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.649742e-01 0.248 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.192978e-01 0.377 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.277885e-01 0.278 0 0
NADPH regeneration R-HSA-389542 6.079723e-01 0.216 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.079723e-01 0.216 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.235890e-01 0.281 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.585132e-01 0.253 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 5.807047e-01 0.236 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.698903e-01 0.244 0 0
Negative regulation of FLT3 R-HSA-9706369 6.154823e-01 0.211 0 0
Passive transport by Aquaporins R-HSA-432047 6.417949e-01 0.193 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.538453e-01 0.185 0 0
Sodium/Proton exchangers R-HSA-425986 6.816449e-01 0.166 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.046918e-01 0.152 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.654428e-01 0.781 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.667841e-01 0.176 0 0
Signaling by TGFB family members R-HSA-9006936 6.702785e-01 0.174 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.494966e-01 0.457 0 0
Interleukin-7 signaling R-HSA-1266695 2.236397e-01 0.650 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.848956e-01 0.233 0 0
TNFs bind their physiological receptors R-HSA-5669034 6.034905e-01 0.219 0 0
Inositol phosphate metabolism R-HSA-1483249 6.371824e-01 0.196 0 0
Glucose metabolism R-HSA-70326 6.045100e-01 0.219 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.333364e-01 0.632 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.460484e-01 0.609 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.574533e-01 0.254 0 0
Potential therapeutics for SARS R-HSA-9679191 6.714386e-01 0.173 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.469388e-01 0.262 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.553656e-01 0.342 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.171349e-01 0.499 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.547578e-01 0.450 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.274940e-01 0.369 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.172631e-01 0.286 0 0
OAS antiviral response R-HSA-8983711 4.956860e-01 0.305 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.628404e-01 0.335 0 0
Lipid particle organization R-HSA-8964572 6.079723e-01 0.216 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.877100e-01 0.231 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.925813e-01 0.227 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.975521e-01 0.224 0 0
CHL1 interactions R-HSA-447041 6.467227e-01 0.189 0 0
Synthesis of PG R-HSA-1483148 6.417949e-01 0.193 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.608241e-01 0.180 0 0
Regulation of beta-cell development R-HSA-186712 5.459918e-01 0.263 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.614751e-01 0.251 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.614751e-01 0.251 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.614751e-01 0.251 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.614751e-01 0.251 0 0
Stimuli-sensing channels R-HSA-2672351 3.700102e-01 0.432 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.196018e-01 0.658 0 0
GAB1 signalosome R-HSA-180292 4.283807e-01 0.368 0 0
G1/S-Specific Transcription R-HSA-69205 6.534241e-01 0.185 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.577837e-01 0.446 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.169160e-01 0.499 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.211799e-01 0.283 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.816449e-01 0.166 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.861664e-01 0.164 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.534911e-01 0.814 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.622252e-01 0.335 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.816449e-01 0.166 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.339952e-01 0.631 0 0
RMTs methylate histone arginines R-HSA-3214858 4.555248e-01 0.341 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.154823e-01 0.211 0 0
Platelet sensitization by LDL R-HSA-432142 2.196018e-01 0.658 0 0
HDL assembly R-HSA-8963896 2.887941e-01 0.539 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.584744e-01 0.253 0 0
Signaling by Leptin R-HSA-2586552 3.916162e-01 0.407 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.614751e-01 0.251 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.553656e-01 0.342 0 0
Interleukin-12 signaling R-HSA-9020591 3.779604e-01 0.423 0 0
Interleukin-37 signaling R-HSA-9008059 1.761355e-01 0.754 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.034905e-01 0.219 0 0
Interleukin-12 family signaling R-HSA-447115 5.406514e-01 0.267 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.901207e-01 0.161 0 0
Signaling by ERBB2 R-HSA-1227986 7.090932e-01 0.149 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.121984e-01 0.147 0 0
Regulation of signaling by CBL R-HSA-912631 7.121984e-01 0.147 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.121984e-01 0.147 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.130823e-01 0.147 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.130823e-01 0.147 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.130823e-01 0.147 0 0
WNT mediated activation of DVL R-HSA-201688 7.131167e-01 0.147 0 0
CASP8 activity is inhibited R-HSA-5218900 7.131167e-01 0.147 0 0
Gap junction degradation R-HSA-190873 7.131167e-01 0.147 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.131167e-01 0.147 0 0
Unwinding of DNA R-HSA-176974 7.131167e-01 0.147 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.131167e-01 0.147 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.131167e-01 0.147 0 0
ARMS-mediated activation R-HSA-170984 7.131167e-01 0.147 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.131167e-01 0.147 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.131167e-01 0.147 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.131167e-01 0.147 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.131167e-01 0.147 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.131167e-01 0.147 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.131167e-01 0.147 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.131167e-01 0.147 0 0
Signaling by Interleukins R-HSA-449147 7.163440e-01 0.145 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.174343e-01 0.144 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.194269e-01 0.143 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.194269e-01 0.143 0 0
Interleukin-2 family signaling R-HSA-451927 7.194269e-01 0.143 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.196452e-01 0.143 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.216304e-01 0.142 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.217077e-01 0.142 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.217077e-01 0.142 0 0
TCR signaling R-HSA-202403 7.217077e-01 0.142 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.219191e-01 0.142 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.219191e-01 0.142 0 0
MAP kinase activation R-HSA-450294 7.219191e-01 0.142 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.223684e-01 0.141 0 0
Activation of BH3-only proteins R-HSA-114452 7.223684e-01 0.141 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.249388e-01 0.140 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.323381e-01 0.135 0 0
Formation of definitive endoderm R-HSA-9823730 7.329415e-01 0.135 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.329415e-01 0.135 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.333709e-01 0.135 0 0
Signaling by PDGF R-HSA-186797 7.343457e-01 0.134 0 0
Heme signaling R-HSA-9707616 7.343457e-01 0.134 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.382117e-01 0.132 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.392082e-01 0.131 0 0
EGFR downregulation R-HSA-182971 7.392082e-01 0.131 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.414791e-01 0.130 0 0
DNA replication initiation R-HSA-68952 7.414791e-01 0.130 0 0
Regulation of CDH11 function R-HSA-9762292 7.414791e-01 0.130 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.414791e-01 0.130 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.414791e-01 0.130 0 0
2-LTR circle formation R-HSA-164843 7.414791e-01 0.130 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.414791e-01 0.130 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.414791e-01 0.130 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.414791e-01 0.130 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.414791e-01 0.130 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.414791e-01 0.130 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.414791e-01 0.130 0 0
Formation of apoptosome R-HSA-111458 7.414791e-01 0.130 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.464323e-01 0.127 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.487416e-01 0.126 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.487416e-01 0.126 0 0
Intra-Golgi traffic R-HSA-6811438 7.487416e-01 0.126 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.497023e-01 0.125 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.523978e-01 0.124 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.523978e-01 0.124 0 0
Signalling to RAS R-HSA-167044 7.523978e-01 0.124 0 0
ERK/MAPK targets R-HSA-198753 7.523978e-01 0.124 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.523978e-01 0.124 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.552267e-01 0.122 0 0
IGF1R signaling cascade R-HSA-2428924 7.580019e-01 0.120 0 0
Insulin receptor signalling cascade R-HSA-74751 7.580019e-01 0.120 0 0
Protein ubiquitination R-HSA-8852135 7.584667e-01 0.120 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.590139e-01 0.120 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.616273e-01 0.118 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.670389e-01 0.115 0 0
LGI-ADAM interactions R-HSA-5682910 7.670389e-01 0.115 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.670389e-01 0.115 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.670389e-01 0.115 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.670389e-01 0.115 0 0
Bicarbonate transporters R-HSA-425381 7.670389e-01 0.115 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.670389e-01 0.115 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.670389e-01 0.115 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.670389e-01 0.115 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.670389e-01 0.115 0 0
PECAM1 interactions R-HSA-210990 7.670389e-01 0.115 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.692348e-01 0.114 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.697285e-01 0.114 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.704421e-01 0.113 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.704421e-01 0.113 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.704421e-01 0.113 0 0
Attachment and Entry R-HSA-9694614 7.706191e-01 0.113 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.706191e-01 0.113 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.706191e-01 0.113 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.711201e-01 0.113 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.731188e-01 0.112 0 0
TBC/RABGAPs R-HSA-8854214 7.756499e-01 0.110 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.800745e-01 0.108 0 0
Platelet homeostasis R-HSA-418346 7.817154e-01 0.107 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.848752e-01 0.105 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.848752e-01 0.105 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.856912e-01 0.105 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.856912e-01 0.105 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.856912e-01 0.105 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.876593e-01 0.104 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.876593e-01 0.104 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.876593e-01 0.104 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.882252e-01 0.103 0 0
Peptide chain elongation R-HSA-156902 7.885720e-01 0.103 0 0
Selective autophagy R-HSA-9663891 7.885720e-01 0.103 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.900730e-01 0.102 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.900730e-01 0.102 0 0
Integration of provirus R-HSA-162592 7.900730e-01 0.102 0 0
NF-kB is activated and signals survival R-HSA-209560 7.900730e-01 0.102 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.900730e-01 0.102 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.900730e-01 0.102 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.900730e-01 0.102 0 0
Sodium/Calcium exchangers R-HSA-425561 7.900730e-01 0.102 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 7.900730e-01 0.102 0 0
HIV Infection R-HSA-162906 7.950979e-01 0.100 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.975607e-01 0.098 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.975607e-01 0.098 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.975607e-01 0.098 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.982005e-01 0.098 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.985484e-01 0.098 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.985484e-01 0.098 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.985484e-01 0.098 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.985484e-01 0.098 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.985484e-01 0.098 0 0
Autophagy R-HSA-9612973 7.997665e-01 0.097 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.002303e-01 0.097 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.002303e-01 0.097 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.002303e-01 0.097 0 0
Adherens junctions interactions R-HSA-418990 8.034716e-01 0.095 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.035738e-01 0.095 0 0
Carnitine shuttle R-HSA-200425 8.035738e-01 0.095 0 0
Growth hormone receptor signaling R-HSA-982772 8.035738e-01 0.095 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.060918e-01 0.094 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.108308e-01 0.091 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.108308e-01 0.091 0 0
Polymerase switching R-HSA-69091 8.108308e-01 0.091 0 0
Leading Strand Synthesis R-HSA-69109 8.108308e-01 0.091 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.108308e-01 0.091 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.108308e-01 0.091 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.108308e-01 0.091 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.108308e-01 0.091 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.108308e-01 0.091 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.108308e-01 0.091 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.108308e-01 0.091 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.108308e-01 0.091 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.108308e-01 0.091 0 0
Estrogen biosynthesis R-HSA-193144 8.108308e-01 0.091 0 0
Interleukin-15 signaling R-HSA-8983432 8.108308e-01 0.091 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.108308e-01 0.091 0 0
Oncogene Induced Senescence R-HSA-2559585 8.114859e-01 0.091 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.116784e-01 0.091 0 0
Signaling by TGFBR3 R-HSA-9839373 8.116784e-01 0.091 0 0
Cell-cell junction organization R-HSA-421270 8.119457e-01 0.090 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.146559e-01 0.089 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.149182e-01 0.089 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.149182e-01 0.089 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.175208e-01 0.088 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.184186e-01 0.087 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.184186e-01 0.087 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.184186e-01 0.087 0 0
Interleukin-17 signaling R-HSA-448424 8.195948e-01 0.086 0 0
Interleukin-1 signaling R-HSA-9020702 8.216108e-01 0.085 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.216108e-01 0.085 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.225840e-01 0.085 0 0
IRE1alpha activates chaperones R-HSA-381070 8.227811e-01 0.085 0 0
GPVI-mediated activation cascade R-HSA-114604 8.237131e-01 0.084 0 0
Chromosome Maintenance R-HSA-73886 8.282264e-01 0.082 0 0
Cellular response to heat stress R-HSA-3371556 8.282264e-01 0.082 0 0
Processing of SMDT1 R-HSA-8949664 8.295372e-01 0.081 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.295372e-01 0.081 0 0
Chylomicron remodeling R-HSA-8963901 8.295372e-01 0.081 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.295372e-01 0.081 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.295372e-01 0.081 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.295372e-01 0.081 0 0
Formation of axial mesoderm R-HSA-9796292 8.295372e-01 0.081 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.295372e-01 0.081 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.295372e-01 0.081 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.295372e-01 0.081 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.295372e-01 0.081 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.295372e-01 0.081 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 8.295372e-01 0.081 0 0
Maturation of nucleoprotein R-HSA-9683610 8.295372e-01 0.081 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.295372e-01 0.081 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.322495e-01 0.080 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.322495e-01 0.080 0 0
Intraflagellar transport R-HSA-5620924 8.329621e-01 0.079 0 0
GPER1 signaling R-HSA-9634597 8.329621e-01 0.079 0 0
Metal ion SLC transporters R-HSA-425410 8.329621e-01 0.079 0 0
Degradation of DVL R-HSA-4641258 8.352560e-01 0.078 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.353642e-01 0.078 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.371359e-01 0.077 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.382006e-01 0.077 0 0
Circadian clock R-HSA-9909396 8.412533e-01 0.075 0 0
Aquaporin-mediated transport R-HSA-445717 8.431472e-01 0.074 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.451218e-01 0.073 0 0
Metalloprotease DUBs R-HSA-5689901 8.451218e-01 0.073 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.451218e-01 0.073 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.451218e-01 0.073 0 0
Removal of the Flap Intermediate R-HSA-69166 8.463947e-01 0.072 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.463947e-01 0.072 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.463947e-01 0.072 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.463947e-01 0.072 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.463947e-01 0.072 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.463947e-01 0.072 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.463947e-01 0.072 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.463947e-01 0.072 0 0
cGMP effects R-HSA-418457 8.463947e-01 0.072 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.463947e-01 0.072 0 0
P2Y receptors R-HSA-417957 8.463947e-01 0.072 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.463947e-01 0.072 0 0
Adaptive Immune System R-HSA-1280218 8.488195e-01 0.071 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.488957e-01 0.071 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.521999e-01 0.069 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.525428e-01 0.069 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.540963e-01 0.068 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.570898e-01 0.067 0 0
Triglyceride biosynthesis R-HSA-75109 8.570898e-01 0.067 0 0
Signaling by BMP R-HSA-201451 8.570898e-01 0.067 0 0
Synthesis of PE R-HSA-1483213 8.570898e-01 0.067 0 0
Insulin processing R-HSA-264876 8.570898e-01 0.067 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.570898e-01 0.067 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.585259e-01 0.066 0 0
Eukaryotic Translation Termination R-HSA-72764 8.593223e-01 0.066 0 0
HSF1-dependent transactivation R-HSA-3371571 8.610926e-01 0.065 0 0
The phototransduction cascade R-HSA-2514856 8.610926e-01 0.065 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.615861e-01 0.065 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.615861e-01 0.065 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.615861e-01 0.065 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.615861e-01 0.065 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.615861e-01 0.065 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.615861e-01 0.065 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.615861e-01 0.065 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.615861e-01 0.065 0 0
Biotin transport and metabolism R-HSA-196780 8.615861e-01 0.065 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.615861e-01 0.065 0 0
p75NTR signals via NF-kB R-HSA-193639 8.615861e-01 0.065 0 0
Other semaphorin interactions R-HSA-416700 8.615861e-01 0.065 0 0
DNA Damage Reversal R-HSA-73942 8.615861e-01 0.065 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.660477e-01 0.062 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.660477e-01 0.062 0 0
Glycogen metabolism R-HSA-8982491 8.660477e-01 0.062 0 0
Generation of second messenger molecules R-HSA-202433 8.660477e-01 0.062 0 0
Developmental Cell Lineages R-HSA-9734767 8.670858e-01 0.062 0 0
Pyroptosis R-HSA-5620971 8.682065e-01 0.061 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.688229e-01 0.061 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.691542e-01 0.061 0 0
Ion channel transport R-HSA-983712 8.692131e-01 0.061 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.695238e-01 0.061 0 0
DNA Repair R-HSA-73894 8.728515e-01 0.059 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.751228e-01 0.058 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.751228e-01 0.058 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.752758e-01 0.058 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.752758e-01 0.058 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 8.752758e-01 0.058 0 0
Activation of SMO R-HSA-5635838 8.752758e-01 0.058 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.752758e-01 0.058 0 0
Fructose catabolism R-HSA-70350 8.752758e-01 0.058 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.752758e-01 0.058 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.752758e-01 0.058 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.752758e-01 0.058 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.752758e-01 0.058 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.775105e-01 0.057 0 0
Signaling by Erythropoietin R-HSA-9006335 8.785231e-01 0.056 0 0
mRNA Capping R-HSA-72086 8.785231e-01 0.056 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.785231e-01 0.056 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.785231e-01 0.056 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.785231e-01 0.056 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.835291e-01 0.054 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.835291e-01 0.054 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.836483e-01 0.054 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.836483e-01 0.054 0 0
HIV Transcription Initiation R-HSA-167161 8.836483e-01 0.054 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.836483e-01 0.054 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.836483e-01 0.054 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.876123e-01 0.052 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.876123e-01 0.052 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.876123e-01 0.052 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.876123e-01 0.052 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.876123e-01 0.052 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.876123e-01 0.052 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.876123e-01 0.052 0 0
Coenzyme A biosynthesis R-HSA-196783 8.876123e-01 0.052 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.876123e-01 0.052 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.876123e-01 0.052 0 0
Activation of the pre-replicative complex R-HSA-68962 8.880891e-01 0.052 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.880891e-01 0.052 0 0
DAP12 signaling R-HSA-2424491 8.880891e-01 0.052 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.880891e-01 0.052 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.880891e-01 0.052 0 0
Downstream TCR signaling R-HSA-202424 8.882832e-01 0.051 0 0
Signaling by FGFR2 R-HSA-5654738 8.939663e-01 0.049 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.942988e-01 0.049 0 0
Selenocysteine synthesis R-HSA-2408557 8.948691e-01 0.048 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.969521e-01 0.047 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.969521e-01 0.047 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.982303e-01 0.047 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.983320e-01 0.047 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.983320e-01 0.047 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.987293e-01 0.046 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.987293e-01 0.046 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.987293e-01 0.046 0 0
Glycogen storage diseases R-HSA-3229121 8.987293e-01 0.046 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 8.987293e-01 0.046 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.987293e-01 0.046 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.987293e-01 0.046 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.987293e-01 0.046 0 0
Catecholamine biosynthesis R-HSA-209905 8.987293e-01 0.046 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.987293e-01 0.046 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.989757e-01 0.046 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.991558e-01 0.046 0 0
Defective pyroptosis R-HSA-9710421 8.991558e-01 0.046 0 0
Signaling by FGFR4 R-HSA-5654743 8.991558e-01 0.046 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.029432e-01 0.044 0 0
Viral mRNA Translation R-HSA-192823 9.049060e-01 0.043 0 0
DNA strand elongation R-HSA-69190 9.051573e-01 0.043 0 0
HS-GAG degradation R-HSA-2024096 9.051573e-01 0.043 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.054536e-01 0.043 0 0
Amine ligand-binding receptors R-HSA-375280 9.061891e-01 0.043 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.070412e-01 0.042 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.072174e-01 0.042 0 0
Host Interactions of HIV factors R-HSA-162909 9.073053e-01 0.042 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.087472e-01 0.042 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.087472e-01 0.042 0 0
Apoptotic factor-mediated response R-HSA-111471 9.087472e-01 0.042 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 9.087472e-01 0.042 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.087472e-01 0.042 0 0
Mismatch Repair R-HSA-5358508 9.087472e-01 0.042 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.087472e-01 0.042 0 0
Tie2 Signaling R-HSA-210993 9.087472e-01 0.042 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.087472e-01 0.042 0 0
PPARA activates gene expression R-HSA-1989781 9.093393e-01 0.041 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.096122e-01 0.041 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.096122e-01 0.041 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.104185e-01 0.041 0 0
rRNA processing R-HSA-72312 9.115471e-01 0.040 0 0
Neuronal System R-HSA-112316 9.120317e-01 0.040 1 0
Defective B3GALTL causes PpS R-HSA-5083635 9.127483e-01 0.040 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.127752e-01 0.040 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.127752e-01 0.040 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.127752e-01 0.040 0 0
Signaling by FGFR3 R-HSA-5654741 9.127752e-01 0.040 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.127752e-01 0.040 1 1
Extension of Telomeres R-HSA-180786 9.170530e-01 0.038 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.177746e-01 0.037 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.177746e-01 0.037 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.177746e-01 0.037 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.177746e-01 0.037 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.177746e-01 0.037 0 0
Diseases of hemostasis R-HSA-9671793 9.177746e-01 0.037 0 0
Maturation of nucleoprotein R-HSA-9694631 9.177746e-01 0.037 0 0
The NLRP3 inflammasome R-HSA-844456 9.177746e-01 0.037 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.177746e-01 0.037 0 0
Nucleotide Excision Repair R-HSA-5696398 9.184313e-01 0.037 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.189379e-01 0.037 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 9.197662e-01 0.036 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.197662e-01 0.036 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.197662e-01 0.036 0 0
Toll-like Receptor Cascades R-HSA-168898 9.198035e-01 0.036 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.210422e-01 0.036 0 0
Transmission across Chemical Synapses R-HSA-112315 9.211825e-01 0.036 1 0
ER to Golgi Anterograde Transport R-HSA-199977 9.220193e-01 0.035 0 0
Interferon gamma signaling R-HSA-877300 9.235779e-01 0.035 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.259095e-01 0.033 0 0
Glycogen synthesis R-HSA-3322077 9.259095e-01 0.033 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.259095e-01 0.033 0 0
Negative regulation of MET activity R-HSA-6807004 9.259095e-01 0.033 0 0
Signaling by NODAL R-HSA-1181150 9.259095e-01 0.033 0 0
Pregnenolone biosynthesis R-HSA-196108 9.259095e-01 0.033 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.262501e-01 0.033 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.262501e-01 0.033 0 0
Telomere Maintenance R-HSA-157579 9.311495e-01 0.031 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.321804e-01 0.031 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.322369e-01 0.030 0 0
PERK regulates gene expression R-HSA-381042 9.322369e-01 0.030 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.322369e-01 0.030 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.322369e-01 0.030 0 0
Phospholipid metabolism R-HSA-1483257 9.326768e-01 0.030 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 9.332400e-01 0.030 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.332400e-01 0.030 0 0
Lagging Strand Synthesis R-HSA-69186 9.332400e-01 0.030 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.332400e-01 0.030 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.332400e-01 0.030 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.332400e-01 0.030 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.332400e-01 0.030 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.332400e-01 0.030 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.332400e-01 0.030 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.332400e-01 0.030 0 0
Basigin interactions R-HSA-210991 9.332400e-01 0.030 0 0
Parasite infection R-HSA-9664407 9.341333e-01 0.030 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.341333e-01 0.030 0 0
Leishmania phagocytosis R-HSA-9664417 9.341333e-01 0.030 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.349035e-01 0.029 0 0
Degradation of CDH1 R-HSA-9766229 9.351135e-01 0.029 0 0
Gap junction trafficking and regulation R-HSA-157858 9.351135e-01 0.029 0 0
HS-GAG biosynthesis R-HSA-2022928 9.377615e-01 0.028 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.377615e-01 0.028 0 0
Glycosphingolipid transport R-HSA-9845576 9.377615e-01 0.028 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.377615e-01 0.028 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.378235e-01 0.028 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.398061e-01 0.027 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.398456e-01 0.027 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.398456e-01 0.027 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.398456e-01 0.027 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.408294e-01 0.026 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.428567e-01 0.026 0 0
Voltage gated Potassium channels R-HSA-1296072 9.428567e-01 0.026 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.428567e-01 0.026 0 0
NCAM1 interactions R-HSA-419037 9.428567e-01 0.026 0 0
PCP/CE pathway R-HSA-4086400 9.436301e-01 0.025 0 0
Meiotic recombination R-HSA-912446 9.441827e-01 0.025 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.441827e-01 0.025 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.457979e-01 0.024 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.457979e-01 0.024 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.457979e-01 0.024 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.457979e-01 0.024 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.457979e-01 0.024 0 0
Signaling by KIT in disease R-HSA-9669938 9.457979e-01 0.024 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.457979e-01 0.024 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.457979e-01 0.024 0 0
Fructose metabolism R-HSA-5652084 9.457979e-01 0.024 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.457979e-01 0.024 0 0
Orc1 removal from chromatin R-HSA-68949 9.482621e-01 0.023 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.482621e-01 0.023 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.482621e-01 0.023 0 0
Influenza Infection R-HSA-168255 9.494450e-01 0.023 0 0
Leishmania infection R-HSA-9658195 9.496975e-01 0.022 1 0
Parasitic Infection Pathways R-HSA-9824443 9.496975e-01 0.022 1 0
Signaling by MET R-HSA-6806834 9.504376e-01 0.022 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.511616e-01 0.022 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.511616e-01 0.022 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.511616e-01 0.022 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.511616e-01 0.022 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.511616e-01 0.022 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.511616e-01 0.022 0 0
Biosynthesis of maresins R-HSA-9018682 9.511616e-01 0.022 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.511616e-01 0.022 0 0
Vesicle-mediated transport R-HSA-5653656 9.514473e-01 0.022 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.518804e-01 0.021 0 0
Stabilization of p53 R-HSA-69541 9.518804e-01 0.021 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.520624e-01 0.021 0 0
Cellular response to starvation R-HSA-9711097 9.530754e-01 0.021 0 0
Signaling by Insulin receptor R-HSA-74752 9.532359e-01 0.021 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.548087e-01 0.020 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.558650e-01 0.020 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.558650e-01 0.020 0 0
Diseases of Immune System R-HSA-5260271 9.558650e-01 0.020 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.559948e-01 0.020 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.559948e-01 0.020 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.559948e-01 0.020 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.559948e-01 0.020 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.559948e-01 0.020 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.563721e-01 0.019 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.563721e-01 0.019 0 0
RSV-host interactions R-HSA-9833110 9.563721e-01 0.019 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.588932e-01 0.018 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.592554e-01 0.018 0 0
Hemostasis R-HSA-109582 9.594107e-01 0.018 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.595326e-01 0.018 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.595326e-01 0.018 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.603499e-01 0.018 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.603499e-01 0.018 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.603499e-01 0.018 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.603499e-01 0.018 0 0
G protein gated Potassium channels R-HSA-1296059 9.603499e-01 0.018 0 0
Hyaluronan degradation R-HSA-2160916 9.603499e-01 0.018 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.603499e-01 0.018 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.603499e-01 0.018 0 0
Laminin interactions R-HSA-3000157 9.603499e-01 0.018 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.603499e-01 0.018 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.603499e-01 0.018 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.611425e-01 0.017 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.618592e-01 0.017 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.619555e-01 0.017 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.619555e-01 0.017 0 0
Signaling by FGFR1 R-HSA-5654736 9.619555e-01 0.017 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.619555e-01 0.017 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.619757e-01 0.017 0 0
Gene Silencing by RNA R-HSA-211000 9.634438e-01 0.016 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.634945e-01 0.016 0 0
Retinoid metabolism and transport R-HSA-975634 9.637564e-01 0.016 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.637564e-01 0.016 0 0
MET activates PTK2 signaling R-HSA-8874081 9.642743e-01 0.016 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.642743e-01 0.016 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.642743e-01 0.016 0 0
Sphingolipid catabolism R-HSA-9845614 9.642743e-01 0.016 0 0
Neddylation R-HSA-8951664 9.643166e-01 0.016 0 0
Regulation of CDH1 Function R-HSA-9764561 9.648023e-01 0.016 0 0
SARS-CoV Infections R-HSA-9679506 9.651451e-01 0.015 0 0
Potassium Channels R-HSA-1296071 9.657158e-01 0.015 0 0
Dual incision in TC-NER R-HSA-6782135 9.674474e-01 0.014 0 0
Packaging Of Telomere Ends R-HSA-171306 9.678104e-01 0.014 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.678104e-01 0.014 0 0
Cristae formation R-HSA-8949613 9.678104e-01 0.014 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.678104e-01 0.014 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.678104e-01 0.014 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.678104e-01 0.014 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.678104e-01 0.014 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.678104e-01 0.014 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.678104e-01 0.014 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.685982e-01 0.014 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.688622e-01 0.014 0 0
Defensins R-HSA-1461973 9.688622e-01 0.014 0 0
Signaling by FGFR R-HSA-190236 9.697915e-01 0.013 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.699040e-01 0.013 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.699040e-01 0.013 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.709811e-01 0.013 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.709967e-01 0.013 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.709967e-01 0.013 0 0
Inflammasomes R-HSA-622312 9.709967e-01 0.013 0 0
DAP12 interactions R-HSA-2172127 9.714831e-01 0.013 0 0
Surfactant metabolism R-HSA-5683826 9.714831e-01 0.013 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.721843e-01 0.012 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.728308e-01 0.012 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.738678e-01 0.011 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.738678e-01 0.011 0 0
Thyroxine biosynthesis R-HSA-209968 9.738678e-01 0.011 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.738678e-01 0.011 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.738678e-01 0.011 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.738678e-01 0.011 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.738905e-01 0.011 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.738905e-01 0.011 0 0
Somitogenesis R-HSA-9824272 9.738905e-01 0.011 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.761009e-01 0.011 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.761009e-01 0.011 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.761009e-01 0.011 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.762627e-01 0.010 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.762627e-01 0.010 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 9.764549e-01 0.010 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.764549e-01 0.010 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.764549e-01 0.010 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.766377e-01 0.010 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.781298e-01 0.010 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.781298e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.781298e-01 0.010 0 0
Interleukin-10 signaling R-HSA-6783783 9.781883e-01 0.010 0 0
Integrin cell surface interactions R-HSA-216083 9.781883e-01 0.010 0 0
Budding and maturation of HIV virion R-HSA-162588 9.787859e-01 0.009 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.787859e-01 0.009 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.787859e-01 0.009 0 0
Cargo concentration in the ER R-HSA-5694530 9.787859e-01 0.009 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.787859e-01 0.009 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.787859e-01 0.009 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.787859e-01 0.009 0 0
Ion transport by P-type ATPases R-HSA-936837 9.797681e-01 0.009 0 0
Ribosome-associated quality control R-HSA-9948299 9.798793e-01 0.009 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.799913e-01 0.009 0 0
Gluconeogenesis R-HSA-70263 9.799913e-01 0.009 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.806592e-01 0.008 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.808863e-01 0.008 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.808863e-01 0.008 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.808863e-01 0.008 0 0
Cellular response to hypoxia R-HSA-1234174 9.813299e-01 0.008 0 0
DNA Damage Bypass R-HSA-73893 9.816987e-01 0.008 0 0
Mitochondrial biogenesis R-HSA-1592230 9.824848e-01 0.008 0 0
Amyloid fiber formation R-HSA-977225 9.825388e-01 0.008 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.825388e-01 0.008 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.825388e-01 0.008 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.827789e-01 0.008 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.827789e-01 0.008 0 0
Recycling of bile acids and salts R-HSA-159418 9.827789e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.831793e-01 0.007 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.841148e-01 0.007 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.844841e-01 0.007 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.844841e-01 0.007 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.844841e-01 0.007 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.844841e-01 0.007 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.844841e-01 0.007 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.860076e-01 0.006 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.860146e-01 0.006 0 0
eNOS activation R-HSA-203615 9.860206e-01 0.006 0 0
Hyaluronan metabolism R-HSA-2142845 9.860206e-01 0.006 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.860206e-01 0.006 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.860206e-01 0.006 0 0
Signaling by NOTCH2 R-HSA-1980145 9.860206e-01 0.006 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.860206e-01 0.006 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.860206e-01 0.006 0 0
Signal amplification R-HSA-392518 9.860206e-01 0.006 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.860206e-01 0.006 0 0
Mitophagy R-HSA-5205647 9.860206e-01 0.006 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.864699e-01 0.006 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.872194e-01 0.006 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.874050e-01 0.006 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.874050e-01 0.006 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.874050e-01 0.006 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.874050e-01 0.006 0 0
Regulation of Apoptosis R-HSA-169911 9.874050e-01 0.006 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.874050e-01 0.006 0 0
Cellular response to chemical stress R-HSA-9711123 9.874331e-01 0.005 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.874694e-01 0.005 0 0
COPII-mediated vesicle transport R-HSA-204005 9.875585e-01 0.005 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.875585e-01 0.005 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.880185e-01 0.005 0 0
G alpha (s) signalling events R-HSA-418555 9.881023e-01 0.005 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.883228e-01 0.005 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.885377e-01 0.005 0 0
ECM proteoglycans R-HSA-3000178 9.885377e-01 0.005 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.886524e-01 0.005 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.886524e-01 0.005 0 0
HSF1 activation R-HSA-3371511 9.886524e-01 0.005 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.886524e-01 0.005 0 0
Neutrophil degranulation R-HSA-6798695 9.890614e-01 0.005 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.893332e-01 0.005 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.894425e-01 0.005 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.897763e-01 0.004 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.897763e-01 0.004 0 0
Degradation of AXIN R-HSA-4641257 9.897763e-01 0.004 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.897763e-01 0.004 0 0
Cleavage of the damaged purine R-HSA-110331 9.897763e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.897763e-01 0.004 0 0
Gastrulation R-HSA-9758941 9.900993e-01 0.004 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.902580e-01 0.004 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.905091e-01 0.004 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.907890e-01 0.004 0 0
Depurination R-HSA-73927 9.907890e-01 0.004 0 0
Purine salvage R-HSA-74217 9.907890e-01 0.004 0 0
Elastic fibre formation R-HSA-1566948 9.907890e-01 0.004 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.907890e-01 0.004 0 0
GPCR downstream signalling R-HSA-388396 9.908182e-01 0.004 1 0
Dectin-2 family R-HSA-5621480 9.911043e-01 0.004 0 0
Synthesis of PA R-HSA-1483166 9.911043e-01 0.004 0 0
Interferon Signaling R-HSA-913531 9.916377e-01 0.004 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.916410e-01 0.004 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.917014e-01 0.004 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.917014e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.917014e-01 0.004 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.917625e-01 0.004 0 0
Iron uptake and transport R-HSA-917937 9.917625e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.920243e-01 0.003 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.925235e-01 0.003 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.925235e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.925377e-01 0.003 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.925869e-01 0.003 0 0
Peroxisomal protein import R-HSA-9033241 9.925869e-01 0.003 0 0
GABA receptor activation R-HSA-977443 9.932346e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.932346e-01 0.003 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.932642e-01 0.003 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.932642e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.932642e-01 0.003 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.932642e-01 0.003 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.938268e-01 0.003 0 0
Collagen degradation R-HSA-1442490 9.938268e-01 0.003 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.939315e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9683701 9.939315e-01 0.003 0 0
HCMV Early Events R-HSA-9609690 9.939831e-01 0.003 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.940179e-01 0.003 0 0
tRNA processing R-HSA-72306 9.941328e-01 0.003 0 0
Synthesis of DNA R-HSA-69239 9.942996e-01 0.002 0 0
Activation of GABAB receptors R-HSA-991365 9.945328e-01 0.002 0 0
GABA B receptor activation R-HSA-977444 9.945328e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.945328e-01 0.002 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.945328e-01 0.002 0 0
Depyrimidination R-HSA-73928 9.945328e-01 0.002 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.946078e-01 0.002 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.947605e-01 0.002 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.948043e-01 0.002 0 0
Complex I biogenesis R-HSA-6799198 9.948627e-01 0.002 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.950745e-01 0.002 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.950864e-01 0.002 0 0
Visual phototransduction R-HSA-2187338 9.952487e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.955626e-01 0.002 0 0
Proteasome assembly R-HSA-9907900 9.955626e-01 0.002 0 0
Gap junction trafficking R-HSA-190828 9.955626e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.955626e-01 0.002 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.957437e-01 0.002 0 0
Cellular responses to stress R-HSA-2262752 9.957625e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.961046e-01 0.002 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.961660e-01 0.002 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.962749e-01 0.002 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.963985e-01 0.002 0 0
Nicotinate metabolism R-HSA-196807 9.964490e-01 0.002 0 0
Metabolism of steroid hormones R-HSA-196071 9.964490e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.965863e-01 0.001 1 1
Cellular responses to stimuli R-HSA-8953897 9.966153e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.967554e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.967634e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.967634e-01 0.001 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.967634e-01 0.001 0 0
Platelet degranulation R-HSA-114608 9.968240e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.970067e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.973668e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.975512e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.978029e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.978629e-01 0.001 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.978629e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.979688e-01 0.001 1 0
Leishmania parasite growth and survival R-HSA-9664433 9.979688e-01 0.001 1 0
Signaling by NOTCH4 R-HSA-9013694 9.981495e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.981495e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.983079e-01 0.001 1 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.983625e-01 0.001 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.984376e-01 0.001 0 0
Selenoamino acid metabolism R-HSA-2408522 9.984859e-01 0.001 0 0
G alpha (z) signalling events R-HSA-418597 9.985926e-01 0.001 0 0
Signaling by NOTCH3 R-HSA-9012852 9.985926e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.986032e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.986238e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.986567e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.987285e-01 0.001 0 0
Digestion R-HSA-8935690 9.987321e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.987491e-01 0.001 1 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.988427e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.989001e-01 0.000 0 0
PKR-mediated signaling R-HSA-9833482 9.989468e-01 0.000 0 0
Signaling by NOTCH R-HSA-157118 9.990790e-01 0.000 0 0
Co-inhibition by PD-1 R-HSA-389948 9.991276e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.991384e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.991651e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.992479e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.992479e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.992703e-01 0.000 0 0
Mitochondrial protein import R-HSA-1268020 9.993225e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.993824e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.993897e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.995048e-01 0.000 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.995063e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.995919e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.995982e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.996290e-01 0.000 0 0
DNA Replication R-HSA-69306 9.996395e-01 0.000 0 0
Protein localization R-HSA-9609507 9.996395e-01 0.000 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.996628e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.996647e-01 0.000 0 0
Protein folding R-HSA-391251 9.997214e-01 0.000 0 0
HCMV Late Events R-HSA-9610379 9.997359e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.997437e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.997469e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.997581e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997617e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.997854e-01 0.000 0 0
HCMV Infection R-HSA-9609646 9.998016e-01 0.000 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.998259e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998259e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998275e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.998408e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998708e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998728e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.998728e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.998826e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.998998e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999070e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999093e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999129e-01 0.000 0 0
Immune System R-HSA-168256 9.999207e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999276e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999278e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999553e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999595e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999597e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999667e-01 0.000 0 0
Base Excision Repair R-HSA-73884 9.999673e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999673e-01 0.000 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.999698e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999859e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999878e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999885e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999932e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999938e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999967e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999983e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999985e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.999986e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999986e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999992e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999992e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999995e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999995e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999995e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999997e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999998e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999998e-01 0.000 0 0
Translation R-HSA-72766 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 1 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.059153e-12 11.975 0 0
HSF1-dependent transactivation R-HSA-3371571 1.331157e-12 11.876 0 0
Attenuation phase R-HSA-3371568 1.902589e-12 11.721 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.837319e-11 10.736 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.347029e-10 9.629 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.347029e-10 9.629 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.511837e-10 9.454 0 0
Cellular responses to stress R-HSA-2262752 3.366984e-10 9.473 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.661390e-10 9.116 0 0
Signaling by ROBO receptors R-HSA-376176 9.144147e-10 9.039 0 0
Cellular responses to stimuli R-HSA-8953897 1.024877e-09 8.989 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.253076e-09 8.902 0 0
Axon guidance R-HSA-422475 3.351017e-09 8.475 0 0
Nervous system development R-HSA-9675108 8.752343e-09 8.058 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.246006e-08 7.904 0 0
HSF1 activation R-HSA-3371511 1.558824e-08 7.807 0 0
Apoptotic execution phase R-HSA-75153 2.418574e-08 7.616 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.118732e-08 7.506 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.118732e-08 7.506 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.393966e-08 7.268 0 0
Peptide chain elongation R-HSA-156902 6.698422e-08 7.174 0 0
Chromatin organization R-HSA-4839726 1.502521e-07 6.823 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.573199e-07 6.803 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.216518e-07 6.493 0 0
Chromatin modifying enzymes R-HSA-3247509 3.603946e-07 6.443 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.099252e-07 6.387 0 0
Cell-Cell communication R-HSA-1500931 5.169436e-07 6.287 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.077734e-07 6.216 0 0
Cell Cycle R-HSA-1640170 7.712572e-07 6.113 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.183791e-06 5.927 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.148678e-06 5.940 0 0
Eukaryotic Translation Termination R-HSA-72764 1.215250e-06 5.915 0 0
Metabolism of RNA R-HSA-8953854 1.215859e-06 5.915 0 0
Influenza Infection R-HSA-168255 1.400834e-06 5.854 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.679566e-06 5.775 0 0
HATs acetylate histones R-HSA-3214847 2.389155e-06 5.622 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.425563e-06 5.615 0 0
Cell junction organization R-HSA-446728 2.863814e-06 5.543 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.017682e-06 5.520 0 0
Selenocysteine synthesis R-HSA-2408557 3.305042e-06 5.481 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.339837e-06 5.476 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.611788e-06 5.442 0 0
Mitotic Prophase R-HSA-68875 4.105733e-06 5.387 0 0
Viral mRNA Translation R-HSA-192823 4.533057e-06 5.344 0 0
M Phase R-HSA-68886 4.525804e-06 5.344 0 0
Nucleosome assembly R-HSA-774815 6.347623e-06 5.197 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.347623e-06 5.197 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.054625e-06 5.094 0 0
Cell Cycle, Mitotic R-HSA-69278 8.082031e-06 5.092 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.912745e-06 5.102 0 0
Meiotic synapsis R-HSA-1221632 1.044609e-05 4.981 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.270564e-05 4.896 0 0
Cell Cycle Checkpoints R-HSA-69620 1.839536e-05 4.735 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.099322e-05 4.678 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.301249e-05 4.638 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.451755e-05 4.611 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.020834e-05 4.520 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.065974e-05 4.513 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.443235e-05 4.463 0 0
Signal Transduction R-HSA-162582 3.366519e-05 4.473 1 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.505386e-05 4.455 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.666947e-05 4.436 0 0
Adherens junctions interactions R-HSA-418990 4.085512e-05 4.389 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.953039e-05 4.403 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.226541e-05 4.374 0 0
DNA Double Strand Break Response R-HSA-5693606 4.675227e-05 4.330 0 0
Cellular response to starvation R-HSA-9711097 4.731894e-05 4.325 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.008586e-05 4.300 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.267044e-05 4.278 0 0
Ribosome-associated quality control R-HSA-9948299 5.900388e-05 4.229 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.074287e-05 4.217 0 0
rRNA processing R-HSA-72312 6.807653e-05 4.167 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.978120e-05 4.098 0 0
Cell-cell junction organization R-HSA-421270 8.270462e-05 4.082 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.337736e-05 4.079 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.395728e-05 4.076 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.412627e-05 4.026 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.069854e-04 3.971 0 0
Translation initiation complex formation R-HSA-72649 1.460107e-04 3.836 0 0
Post NMDA receptor activation events R-HSA-438064 1.465471e-04 3.834 1 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.682969e-04 3.774 0 0
G2/M Checkpoints R-HSA-69481 1.776674e-04 3.750 0 0
Packaging Of Telomere Ends R-HSA-171306 1.887117e-04 3.724 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.887117e-04 3.724 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.032976e-04 3.692 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.072391e-04 3.684 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.276444e-04 3.643 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.284368e-04 3.641 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.284368e-04 3.641 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.688564e-04 3.570 0 0
DAG and IP3 signaling R-HSA-1489509 2.935638e-04 3.532 1 0
DNA methylation R-HSA-5334118 3.090099e-04 3.510 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.103934e-04 3.508 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.172837e-04 3.499 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.222706e-04 3.492 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.392343e-04 3.470 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.526915e-04 3.453 0 0
Recycling pathway of L1 R-HSA-437239 4.217168e-04 3.375 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.961898e-04 3.304 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.961898e-04 3.304 1 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.170947e-04 3.286 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.287859e-04 3.277 0 0
Mitotic Anaphase R-HSA-68882 5.516764e-04 3.258 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.585413e-04 3.253 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.948709e-04 3.226 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.062526e-04 3.217 0 0
Mitotic Prometaphase R-HSA-68877 6.186453e-04 3.209 0 0
Defective pyroptosis R-HSA-9710421 6.576208e-04 3.182 0 0
Apoptosis R-HSA-109581 6.952888e-04 3.158 0 0
ESR-mediated signaling R-HSA-8939211 7.260331e-04 3.139 0 0
mRNA Splicing R-HSA-72172 8.111311e-04 3.091 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.505624e-04 3.125 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.189796e-04 3.087 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.378478e-04 3.077 0 0
Cellular Senescence R-HSA-2559583 8.421399e-04 3.075 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.992387e-04 3.046 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 9.355784e-04 3.029 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.374818e-04 3.028 0 0
mRNA 3'-end processing R-HSA-72187 9.652821e-04 3.015 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.015996e-03 2.993 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.148049e-03 2.940 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.224804e-03 2.912 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.224804e-03 2.912 0 0
Protein ubiquitination R-HSA-8852135 1.210038e-03 2.917 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.247438e-03 2.904 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.261191e-03 2.899 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.539981e-03 2.812 0 0
HDACs deacetylate histones R-HSA-3214815 1.513213e-03 2.820 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.633827e-03 2.787 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.635114e-03 2.786 0 0
Calmodulin induced events R-HSA-111933 1.609676e-03 2.793 1 0
CaM pathway R-HSA-111997 1.609676e-03 2.793 1 0
Cell-extracellular matrix interactions R-HSA-446353 1.539981e-03 2.812 0 0
Meiosis R-HSA-1500620 1.635114e-03 2.786 0 0
Separation of Sister Chromatids R-HSA-2467813 1.635475e-03 2.786 0 0
Ca-dependent events R-HSA-111996 1.713662e-03 2.766 1 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.713662e-03 2.766 0 0
Depyrimidination R-HSA-73928 1.713662e-03 2.766 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.738422e-03 2.760 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.920253e-03 2.717 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.920253e-03 2.717 0 0
Cleavage of the damaged purine R-HSA-110331 1.920253e-03 2.717 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.208257e-03 2.656 0 0
PKR-mediated signaling R-HSA-9833482 2.208257e-03 2.656 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.528823e-03 2.597 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.528823e-03 2.597 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.363084e-03 2.627 0 0
Gap junction trafficking R-HSA-190828 2.352559e-03 2.628 0 0
Depurination R-HSA-73927 2.277920e-03 2.642 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.546670e-03 2.594 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.587350e-03 2.587 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.614782e-03 2.583 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.687743e-03 2.571 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.687743e-03 2.571 0 0
Formation of annular gap junctions R-HSA-196025 2.956140e-03 2.529 0 0
Kinesins R-HSA-983189 2.989981e-03 2.524 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.019869e-03 2.520 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.155063e-03 2.501 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.173545e-03 2.498 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.173545e-03 2.498 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.173545e-03 2.498 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.394518e-03 2.469 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.199134e-03 2.495 0 0
Aggrephagy R-HSA-9646399 3.155063e-03 2.501 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.435875e-03 2.464 0 0
Signaling by RAS mutants R-HSA-6802949 3.173545e-03 2.498 0 0
PLC beta mediated events R-HSA-112043 3.394518e-03 2.469 1 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.449278e-03 2.462 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.644480e-03 2.438 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.685485e-03 2.434 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.986886e-03 2.399 0 0
RNA Polymerase I Transcription R-HSA-73864 4.169710e-03 2.380 0 0
Gap junction degradation R-HSA-190873 4.258482e-03 2.371 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.258482e-03 2.371 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.284867e-03 2.368 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.284867e-03 2.368 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.376639e-03 2.359 0 0
Gene Silencing by RNA R-HSA-211000 4.553618e-03 2.342 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.330162e-03 2.273 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.330162e-03 2.273 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.330162e-03 2.273 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.330162e-03 2.273 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.330162e-03 2.273 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.330162e-03 2.273 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.330162e-03 2.273 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.330162e-03 2.273 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.330162e-03 2.273 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.330162e-03 2.273 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.330162e-03 2.273 0 0
HCMV Early Events R-HSA-9609690 4.954279e-03 2.305 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.217799e-03 2.283 0 0
Programmed Cell Death R-HSA-5357801 5.285265e-03 2.277 0 0
Gap junction trafficking and regulation R-HSA-157858 4.824997e-03 2.317 0 0
Death Receptor Signaling R-HSA-73887 5.360264e-03 2.271 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.560184e-03 2.255 0 0
Signaling by WNT R-HSA-195721 5.595998e-03 2.252 0 0
Selective autophagy R-HSA-9663891 5.713600e-03 2.243 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.790454e-03 2.237 0 0
Selenoamino acid metabolism R-HSA-2408522 5.845645e-03 2.233 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.925524e-03 2.227 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.313048e-03 2.200 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.313048e-03 2.200 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.781617e-03 2.169 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.781617e-03 2.169 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.794997e-03 2.168 0 0
G-protein mediated events R-HSA-112040 6.859742e-03 2.164 1 0
ISG15 antiviral mechanism R-HSA-1169408 6.965766e-03 2.157 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.715320e-03 2.113 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.831361e-03 2.106 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.831361e-03 2.106 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.005476e-03 2.097 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 9.286417e-03 2.032 0 0
Amplification of signal from the kinetochores R-HSA-141424 9.286417e-03 2.032 0 0
Hedgehog 'off' state R-HSA-5610787 9.621829e-03 2.017 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.839845e-03 2.054 0 0
Mitotic Spindle Checkpoint R-HSA-69618 9.621829e-03 2.017 0 0
Chromosome Maintenance R-HSA-73886 8.531401e-03 2.069 0 0
Viral Infection Pathways R-HSA-9824446 9.385467e-03 2.028 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.034153e-03 2.044 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.925499e-03 2.003 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.005118e-02 1.998 0 0
Activation of RAC1 R-HSA-428540 1.054428e-02 1.977 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.058440e-02 1.975 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.076139e-02 1.968 0 0
L1CAM interactions R-HSA-373760 1.123352e-02 1.949 0 0
MAP2K and MAPK activation R-HSA-5674135 1.166614e-02 1.933 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.174936e-02 1.930 0 0
HIV Life Cycle R-HSA-162587 1.193126e-02 1.923 0 0
Diseases of programmed cell death R-HSA-9645723 1.216516e-02 1.915 0 0
Macroautophagy R-HSA-1632852 1.264374e-02 1.898 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.269568e-02 1.896 0 0
Homology Directed Repair R-HSA-5693538 1.303210e-02 1.885 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.333974e-02 1.875 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.333974e-02 1.875 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.333974e-02 1.875 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.333974e-02 1.875 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.333974e-02 1.875 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.333974e-02 1.875 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.366093e-02 1.865 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.390015e-02 1.857 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.611587e-02 1.793 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.691621e-02 1.772 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.672818e-02 1.777 0 0
Metabolism of non-coding RNA R-HSA-194441 1.566768e-02 1.805 0 0
snRNP Assembly R-HSA-191859 1.566768e-02 1.805 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.612210e-02 1.793 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.611587e-02 1.793 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.737056e-02 1.760 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.590091e-02 1.799 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.806909e-02 1.743 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.611587e-02 1.793 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.729253e-02 1.762 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.612210e-02 1.793 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.612210e-02 1.793 0 0
Meiotic recombination R-HSA-912446 1.549792e-02 1.810 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.676174e-02 1.776 0 0
Reproduction R-HSA-1474165 1.862293e-02 1.730 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.889197e-02 1.724 0 0
Autophagy R-HSA-9612973 1.957971e-02 1.708 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.967719e-02 1.706 0 0
G alpha (12/13) signalling events R-HSA-416482 2.001647e-02 1.699 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.001647e-02 1.699 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.058495e-02 1.686 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.111567e-02 1.675 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.118829e-02 1.674 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.132231e-02 1.671 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.136332e-02 1.670 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.136332e-02 1.670 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.136332e-02 1.670 0 0
Unwinding of DNA R-HSA-176974 2.136332e-02 1.670 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.202408e-02 1.657 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.258292e-02 1.646 0 0
Myogenesis R-HSA-525793 2.301300e-02 1.638 0 0
Nephrin family interactions R-HSA-373753 2.307408e-02 1.637 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.320400e-02 1.634 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.321130e-02 1.634 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.321130e-02 1.634 0 0
Semaphorin interactions R-HSA-373755 2.321130e-02 1.634 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.363570e-02 1.626 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.363570e-02 1.626 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.363570e-02 1.626 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.363570e-02 1.626 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.464884e-02 1.608 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.507313e-02 1.601 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.530499e-02 1.597 0 0
Amyloid fiber formation R-HSA-977225 2.572264e-02 1.590 0 0
NRAGE signals death through JNK R-HSA-193648 2.604336e-02 1.584 0 0
DCC mediated attractive signaling R-HSA-418885 2.608379e-02 1.584 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.785565e-02 1.555 0 0
Membrane Trafficking R-HSA-199991 2.793679e-02 1.554 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.836440e-02 1.547 0 0
RAF activation R-HSA-5673000 2.840520e-02 1.547 0 0
Nuclear import of Rev protein R-HSA-180746 2.840520e-02 1.547 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.919404e-02 1.535 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.939902e-02 1.532 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.041509e-02 1.517 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.203104e-02 1.494 0 0
MTOR signalling R-HSA-165159 3.247421e-02 1.488 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.314195e-02 1.480 0 0
Activation of the pre-replicative complex R-HSA-68962 3.941648e-02 1.404 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.941648e-02 1.404 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.020257e-02 1.396 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.896949e-02 1.409 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.314195e-02 1.480 0 0
Neurexins and neuroligins R-HSA-6794361 3.896949e-02 1.409 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.346386e-02 1.475 0 0
Signaling by ALK in cancer R-HSA-9700206 3.346386e-02 1.475 0 0
Signaling by VEGF R-HSA-194138 3.963468e-02 1.402 0 0
MHC class II antigen presentation R-HSA-2132295 3.313629e-02 1.480 0 0
Regulation of TP53 Activity R-HSA-5633007 4.073720e-02 1.390 0 0
Deubiquitination R-HSA-5688426 4.103545e-02 1.387 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.245099e-02 1.372 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.245099e-02 1.372 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.269848e-02 1.370 0 0
NF-kB is activated and signals survival R-HSA-209560 4.277585e-02 1.369 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.408142e-02 1.356 0 0
Signaling by Hippo R-HSA-2028269 4.421873e-02 1.354 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.434079e-02 1.353 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.446639e-02 1.352 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.446639e-02 1.352 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.458363e-02 1.351 0 0
tRNA processing in the nucleus R-HSA-6784531 4.458363e-02 1.351 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.476515e-02 1.349 0 0
Opioid Signalling R-HSA-111885 4.635240e-02 1.334 1 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.645146e-02 1.333 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.666330e-02 1.331 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.843598e-02 1.315 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.851852e-02 1.314 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.851852e-02 1.314 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.932117e-02 1.307 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.932117e-02 1.307 0 0
HCMV Infection R-HSA-9609646 4.986709e-02 1.302 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.086883e-02 1.294 0 0
Ephrin signaling R-HSA-3928664 5.159390e-02 1.287 0 0
PKA activation R-HSA-163615 5.159390e-02 1.287 0 0
PKA activation in glucagon signalling R-HSA-164378 5.159390e-02 1.287 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.185835e-02 1.285 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.296406e-02 1.276 1 0
Telomere Maintenance R-HSA-157579 5.303844e-02 1.275 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.320830e-02 1.274 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.412873e-02 1.267 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.487825e-02 1.261 0 0
TGFBR3 expression R-HSA-9839394 5.509381e-02 1.259 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.576691e-02 1.254 0 0
Nuclear RNA decay R-HSA-9930044 5.576691e-02 1.254 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.576691e-02 1.254 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.717152e-02 1.243 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.717152e-02 1.243 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.717152e-02 1.243 0 0
G2/M Transition R-HSA-69275 5.869533e-02 1.231 0 0
Developmental Biology R-HSA-1266738 5.926505e-02 1.227 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.964424e-02 1.224 0 0
Rap1 signalling R-HSA-392517 5.964424e-02 1.224 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.127623e-02 1.213 0 0
Centrosome maturation R-HSA-380287 6.140912e-02 1.212 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.190791e-02 1.208 1 1
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.202847e-02 1.207 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.252721e-02 1.204 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.287207e-02 1.082 0 0
Axonal growth stimulation R-HSA-209563 7.045560e-02 1.152 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 7.045560e-02 1.152 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.154828e-02 1.145 0 0
Type I hemidesmosome assembly R-HSA-446107 7.154828e-02 1.145 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.154828e-02 1.145 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.154828e-02 1.145 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.290549e-02 1.137 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 7.290549e-02 1.137 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.482304e-02 1.071 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.482304e-02 1.071 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.978186e-02 1.156 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.870194e-02 1.163 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.258724e-02 1.139 0 0
Transcription of the HIV genome R-HSA-167172 7.060355e-02 1.151 0 0
p75NTR signals via NF-kB R-HSA-193639 8.482304e-02 1.071 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.775888e-02 1.109 1 1
EPH-Ephrin signaling R-HSA-2682334 6.469379e-02 1.189 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.290549e-02 1.137 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.399018e-02 1.194 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.634142e-02 1.178 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.578841e-02 1.120 0 0
HIV Infection R-HSA-162906 6.506374e-02 1.187 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.328722e-02 1.079 0 0
Co-inhibition by PD-1 R-HSA-389948 6.991727e-02 1.155 0 0
Regulation of PTEN gene transcription R-HSA-8943724 7.563803e-02 1.121 0 0
DNA Replication R-HSA-69306 7.351142e-02 1.134 0 0
DNA Repair R-HSA-73894 6.796666e-02 1.168 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.258724e-02 1.139 0 0
Glycolysis R-HSA-70171 6.370489e-02 1.196 0 0
G1/S-Specific Transcription R-HSA-69205 8.328722e-02 1.079 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.775888e-02 1.109 0 0
Gap junction assembly R-HSA-190861 6.870194e-02 1.163 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.486673e-02 1.071 0 0
Interleukin-12 signaling R-HSA-9020591 6.580688e-02 1.182 0 0
Translation R-HSA-72766 8.491792e-02 1.071 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.651565e-02 1.063 0 0
DARPP-32 events R-HSA-180024 8.651565e-02 1.063 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.736664e-02 1.059 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.736664e-02 1.059 0 0
Lipophagy R-HSA-9613354 8.736664e-02 1.059 0 0
ALK mutants bind TKIs R-HSA-9700645 8.736664e-02 1.059 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.736664e-02 1.059 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.736664e-02 1.059 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.339145e-02 1.030 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.418142e-02 1.026 0 0
Base Excision Repair R-HSA-73884 9.418142e-02 1.026 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 9.600248e-02 1.018 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 9.600248e-02 1.018 0 0
FGFR2 alternative splicing R-HSA-6803529 9.849299e-02 1.007 0 0
mTORC1-mediated signalling R-HSA-166208 9.849299e-02 1.007 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.962663e-02 1.002 0 0
Interferon Signaling R-HSA-913531 1.005742e-01 0.998 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.010109e-01 0.996 0 0
Regulation of CDH11 function R-HSA-9762292 1.045090e-01 0.981 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.045090e-01 0.981 0 0
PI3K/AKT activation R-HSA-198203 1.045090e-01 0.981 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.045090e-01 0.981 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.064609e-01 0.973 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.064609e-01 0.973 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.064609e-01 0.973 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.082259e-01 0.966 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.112291e-01 0.954 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.122629e-01 0.950 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.145731e-01 0.941 0 0
Regulation of CDH1 Function R-HSA-9764561 1.159298e-01 0.936 0 0
Ub-specific processing proteases R-HSA-5689880 1.163246e-01 0.934 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.172575e-01 0.931 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.173340e-01 0.931 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.217093e-01 0.915 0 0
Signaling by APC mutants R-HSA-4839744 1.228493e-01 0.911 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.228493e-01 0.911 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.228493e-01 0.911 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.228493e-01 0.911 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.237004e-01 0.908 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.237004e-01 0.908 0 0
IRS activation R-HSA-74713 1.237004e-01 0.908 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 1.237004e-01 0.908 0 0
Defective F9 activation R-HSA-9673221 1.237004e-01 0.908 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 1.237004e-01 0.908 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.245964e-01 0.904 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.259112e-01 0.900 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.268266e-01 0.897 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.268266e-01 0.897 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.309990e-01 0.883 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.319587e-01 0.880 0 0
Signaling by Hedgehog R-HSA-5358351 1.323128e-01 0.878 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.341896e-01 0.872 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.345034e-01 0.871 0 0
Interleukin-12 family signaling R-HSA-447115 1.345034e-01 0.871 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.378974e-01 0.860 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.408803e-01 0.851 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.422562e-01 0.847 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.422562e-01 0.847 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.422562e-01 0.847 0 0
Signaling by AXIN mutants R-HSA-4839735 1.422562e-01 0.847 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.422562e-01 0.847 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.443302e-01 0.841 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.588809e-01 0.799 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.588809e-01 0.799 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.588809e-01 0.799 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.530180e-01 0.815 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.530180e-01 0.815 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.530180e-01 0.815 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.530180e-01 0.815 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.530180e-01 0.815 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.530180e-01 0.815 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.834970e-01 0.736 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.834970e-01 0.736 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.834970e-01 0.736 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.147440e-01 0.668 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.147440e-01 0.668 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.147440e-01 0.668 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.147440e-01 0.668 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.147440e-01 0.668 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 2.147440e-01 0.668 0 0
SOS-mediated signalling R-HSA-112412 2.147440e-01 0.668 0 0
Repression of WNT target genes R-HSA-4641265 1.625971e-01 0.789 0 0
Pervasive developmental disorders R-HSA-9005895 1.625971e-01 0.789 0 0
Disorders of Nervous System Development R-HSA-9697154 1.625971e-01 0.789 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.625971e-01 0.789 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.625971e-01 0.789 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.625971e-01 0.789 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.625971e-01 0.789 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.625971e-01 0.789 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.625971e-01 0.789 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.837395e-01 0.736 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.747694e-01 0.758 0 0
HIV elongation arrest and recovery R-HSA-167287 1.747694e-01 0.758 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.747694e-01 0.758 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.747694e-01 0.758 0 0
mRNA Capping R-HSA-72086 1.892324e-01 0.723 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.114091e-01 0.675 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.030344e-01 0.692 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.638098e-01 0.786 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.684194e-01 0.774 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.041048e-01 0.690 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.041048e-01 0.690 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.078252e-01 0.682 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.625971e-01 0.789 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.732258e-01 0.761 0 0
Protein folding R-HSA-391251 1.795730e-01 0.746 0 0
Ion homeostasis R-HSA-5578775 1.946616e-01 0.711 0 0
Frs2-mediated activation R-HSA-170968 1.837395e-01 0.736 0 0
Formation of definitive endoderm R-HSA-9823730 1.732258e-01 0.761 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.530180e-01 0.815 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.837395e-01 0.736 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.055538e-01 0.687 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.030344e-01 0.692 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.157248e-01 0.666 1 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.625971e-01 0.789 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.673116e-01 0.776 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.610162e-01 0.793 0 0
Intraflagellar transport R-HSA-5620924 2.151396e-01 0.667 0 0
TNF signaling R-HSA-75893 1.946616e-01 0.711 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 1.530180e-01 0.815 0 0
Nef and signal transduction R-HSA-164944 1.834970e-01 0.736 0 0
CHL1 interactions R-HSA-447041 2.147440e-01 0.668 0 0
Protein hydroxylation R-HSA-9629569 1.732258e-01 0.761 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.796574e-01 0.746 0 0
Signaling by TGFBR3 R-HSA-9839373 1.912012e-01 0.719 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.605663e-01 0.794 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.530180e-01 0.815 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.826773e-01 0.738 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.567407e-01 0.805 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.169368e-01 0.664 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.943849e-01 0.711 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 1.530180e-01 0.815 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.147440e-01 0.668 0 0
Regulation of PTEN localization R-HSA-8948747 2.147440e-01 0.668 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.078252e-01 0.682 0 0
Glucose metabolism R-HSA-70326 1.703381e-01 0.769 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.216255e-01 0.654 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.684194e-01 0.774 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.118533e-01 0.674 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.585868e-01 0.800 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.946616e-01 0.711 0 0
HIV Transcription Elongation R-HSA-167169 2.250137e-01 0.648 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.250137e-01 0.648 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.258152e-01 0.646 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.279146e-01 0.642 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.279146e-01 0.642 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.279146e-01 0.642 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.279146e-01 0.642 0 0
Protein methylation R-HSA-8876725 2.279146e-01 0.642 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.285944e-01 0.641 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.285944e-01 0.641 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.285944e-01 0.641 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.285944e-01 0.641 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.285944e-01 0.641 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.285944e-01 0.641 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.285944e-01 0.641 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.285944e-01 0.641 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.285944e-01 0.641 0 0
G0 and Early G1 R-HSA-1538133 2.349292e-01 0.629 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.361625e-01 0.627 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.388932e-01 0.622 0 0
Signaling by ERBB2 R-HSA-1227986 2.396725e-01 0.620 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 2.464227e-01 0.608 0 0
Adrenoceptors R-HSA-390696 2.464227e-01 0.608 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.464227e-01 0.608 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.491648e-01 0.604 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.925338e-01 0.534 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.925338e-01 0.534 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.925338e-01 0.534 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.925338e-01 0.534 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.782472e-01 0.556 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 2.782472e-01 0.556 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.049623e-01 0.393 0 0
NADE modulates death signalling R-HSA-205025 4.049623e-01 0.393 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.049623e-01 0.393 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.049623e-01 0.393 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.049623e-01 0.393 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.099759e-01 0.509 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.099759e-01 0.509 0 0
2-LTR circle formation R-HSA-164843 3.099759e-01 0.509 0 0
Phosphorylation of the APC/C R-HSA-176412 2.507016e-01 0.601 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.738008e-01 0.563 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.542919e-01 0.343 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.542919e-01 0.343 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.971051e-01 0.527 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.971051e-01 0.527 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.723699e-01 0.429 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.723699e-01 0.429 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.009403e-01 0.522 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.439366e-01 0.464 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.027284e-01 0.395 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.027284e-01 0.395 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.027284e-01 0.395 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 4.995347e-01 0.301 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 4.995347e-01 0.301 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.202173e-01 0.495 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.202173e-01 0.495 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.202173e-01 0.495 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.202173e-01 0.495 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.672864e-01 0.435 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.323693e-01 0.364 0 0
Formation of axial mesoderm R-HSA-9796292 4.323693e-01 0.364 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 4.323693e-01 0.364 0 0
Orc1 removal from chromatin R-HSA-68949 2.659150e-01 0.575 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.904866e-01 0.408 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.904866e-01 0.408 0 0
Late endosomal microautophagy R-HSA-9615710 3.589797e-01 0.445 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.134671e-01 0.384 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.612031e-01 0.336 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.612031e-01 0.336 0 0
Notch-HLH transcription pathway R-HSA-350054 4.361650e-01 0.360 0 0
Erythropoietin activates RAS R-HSA-9027284 4.891600e-01 0.311 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.891600e-01 0.311 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.891600e-01 0.311 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.585245e-01 0.339 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.585245e-01 0.339 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.177750e-01 0.379 0 0
Deadenylation of mRNA R-HSA-429947 4.804963e-01 0.318 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.379471e-01 0.359 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.988950e-01 0.302 0 0
Neutrophil degranulation R-HSA-6798695 4.806498e-01 0.318 0 0
EGFR downregulation R-HSA-182971 3.976892e-01 0.400 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.508056e-01 0.601 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.027284e-01 0.395 0 0
Integration of provirus R-HSA-162592 3.723699e-01 0.429 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.791028e-01 0.554 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.016454e-01 0.396 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.099759e-01 0.509 0 0
Disorders of Developmental Biology R-HSA-9675151 2.738008e-01 0.563 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.723699e-01 0.429 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.840935e-01 0.315 0 0
Formation of apoptosome R-HSA-111458 3.099759e-01 0.509 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.099759e-01 0.509 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.714885e-01 0.566 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.507016e-01 0.601 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 4.995347e-01 0.301 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.165224e-01 0.500 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.718808e-01 0.430 0 0
Mitochondrial protein import R-HSA-1268020 4.026131e-01 0.395 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.871362e-01 0.412 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.628654e-01 0.580 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.134671e-01 0.384 0 0
Calcineurin activates NFAT R-HSA-2025928 2.782472e-01 0.556 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.099759e-01 0.509 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 4.542919e-01 0.343 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.542919e-01 0.343 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.542919e-01 0.343 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.669408e-01 0.574 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.747722e-01 0.426 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.747722e-01 0.426 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.747722e-01 0.426 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.747722e-01 0.426 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.952677e-01 0.305 0 0
Signaling by WNT in cancer R-HSA-4791275 4.169105e-01 0.380 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.891600e-01 0.311 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.861484e-01 0.313 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.009403e-01 0.522 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.321694e-01 0.364 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.861484e-01 0.313 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.971051e-01 0.527 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 4.995347e-01 0.301 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 4.995347e-01 0.301 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.995347e-01 0.301 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 3.501913e-01 0.456 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.612031e-01 0.336 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.361650e-01 0.360 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.169105e-01 0.380 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.589797e-01 0.445 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.783645e-01 0.422 0 0
eNOS activation R-HSA-203615 4.735659e-01 0.325 0 0
PTEN Regulation R-HSA-6807070 4.814571e-01 0.317 0 0
Platelet sensitization by LDL R-HSA-432142 3.205145e-01 0.494 0 0
Prolonged ERK activation events R-HSA-169893 2.507016e-01 0.601 0 0
Interleukin-33 signaling R-HSA-9014843 2.925338e-01 0.534 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.925338e-01 0.534 0 0
Signalling to ERK5 R-HSA-198765 2.925338e-01 0.534 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.925338e-01 0.534 0 0
MET interacts with TNS proteins R-HSA-8875513 3.511770e-01 0.454 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.511770e-01 0.454 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.511770e-01 0.454 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.507016e-01 0.601 0 0
Bicarbonate transporters R-HSA-425381 3.414063e-01 0.467 0 0
Reelin signalling pathway R-HSA-8866376 4.542919e-01 0.343 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.439366e-01 0.464 0 0
Phosphorylation of Emi1 R-HSA-176417 4.995347e-01 0.301 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 4.995347e-01 0.301 0 0
Ceramide signalling R-HSA-193681 4.995347e-01 0.301 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 4.995347e-01 0.301 0 0
Synthesis of PS R-HSA-1483101 4.995347e-01 0.301 0 0
Negative regulation of MET activity R-HSA-6807004 3.672864e-01 0.435 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.514443e-01 0.600 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.840935e-01 0.315 1 1
Regulation of TNFR1 signaling R-HSA-5357905 3.264819e-01 0.486 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.530217e-01 0.597 0 0
Cilium Assembly R-HSA-5617833 3.556256e-01 0.449 0 0
HCMV Late Events R-HSA-9610379 2.621017e-01 0.582 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.577867e-01 0.339 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.904866e-01 0.408 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.333191e-01 0.477 0 0
Rab regulation of trafficking R-HSA-9007101 4.604906e-01 0.337 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.891600e-01 0.311 0 0
Vesicle-mediated transport R-HSA-5653656 3.617096e-01 0.442 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.669408e-01 0.574 0 0
MAP kinase activation R-HSA-450294 3.886890e-01 0.410 0 0
Signaling by NOTCH1 R-HSA-1980143 4.410286e-01 0.356 0 0
Gene expression (Transcription) R-HSA-74160 3.284819e-01 0.483 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.782472e-01 0.556 0 0
Signal attenuation R-HSA-74749 3.099759e-01 0.509 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.542919e-01 0.343 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.905483e-01 0.537 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.395810e-01 0.469 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.774853e-01 0.321 0 0
HDMs demethylate histones R-HSA-3214842 2.818042e-01 0.550 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.747722e-01 0.426 0 0
FLT3 signaling in disease R-HSA-9682385 3.165224e-01 0.500 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.782472e-01 0.556 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.782472e-01 0.556 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.134671e-01 0.384 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 4.612031e-01 0.336 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.891600e-01 0.311 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.104493e-01 0.387 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.464060e-01 0.350 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.755092e-01 0.560 0 0
Signaling by PTK6 R-HSA-8848021 2.755092e-01 0.560 0 0
RNA Polymerase II Transcription R-HSA-73857 3.884023e-01 0.411 0 0
Host Interactions of HIV factors R-HSA-162909 3.114310e-01 0.507 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.646504e-01 0.333 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.782472e-01 0.556 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.507016e-01 0.601 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.542919e-01 0.343 0 0
Smooth Muscle Contraction R-HSA-445355 2.791028e-01 0.554 0 0
Regulation of KIT signaling R-HSA-1433559 4.612031e-01 0.336 0 0
S Phase R-HSA-69242 3.663116e-01 0.436 0 0
Integration of energy metabolism R-HSA-163685 4.529354e-01 0.344 0 0
Ion transport by P-type ATPases R-HSA-936837 4.304139e-01 0.366 0 0
Signaling by MET R-HSA-6806834 4.920180e-01 0.308 0 0
NGF-stimulated transcription R-HSA-9031628 3.566964e-01 0.448 0 0
Adaptive Immune System R-HSA-1280218 3.211151e-01 0.493 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.815499e-01 0.317 0 0
Signaling by NOTCH R-HSA-157118 4.024355e-01 0.395 0 0
G1/S Transition R-HSA-69206 3.297971e-01 0.482 0 0
RUNX2 regulates bone development R-HSA-8941326 3.165224e-01 0.500 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.345414e-01 0.362 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.511770e-01 0.454 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.049623e-01 0.393 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.414063e-01 0.467 0 0
Interleukin-36 pathway R-HSA-9014826 4.542919e-01 0.343 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.723699e-01 0.429 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.995347e-01 0.301 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.995347e-01 0.301 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.612031e-01 0.336 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.840935e-01 0.315 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.488281e-01 0.457 0 0
Netrin-1 signaling R-HSA-373752 2.966390e-01 0.528 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.840275e-01 0.416 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.361650e-01 0.360 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.691319e-01 0.329 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.894049e-01 0.410 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.691319e-01 0.329 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.691319e-01 0.329 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.009275e-01 0.397 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.754200e-01 0.323 0 0
Basigin interactions R-HSA-210991 3.904866e-01 0.408 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.671050e-01 0.435 0 0
Signaling by NOTCH4 R-HSA-9013694 4.152445e-01 0.382 0 0
Cardiogenesis R-HSA-9733709 4.359881e-01 0.361 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.774853e-01 0.321 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.577867e-01 0.339 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.099759e-01 0.509 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.508056e-01 0.601 0 0
TBC/RABGAPs R-HSA-8854214 4.511999e-01 0.346 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.294477e-01 0.367 0 0
The NLRP3 inflammasome R-HSA-844456 3.439366e-01 0.464 0 0
RMTs methylate histone arginines R-HSA-3214858 2.966390e-01 0.528 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.205145e-01 0.494 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.920004e-01 0.308 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 2.925338e-01 0.534 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.049623e-01 0.393 0 0
Dopamine receptors R-HSA-390651 4.049623e-01 0.393 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.099759e-01 0.509 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 3.099759e-01 0.509 0 0
NrCAM interactions R-HSA-447038 4.542919e-01 0.343 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.585245e-01 0.339 0 0
Signaling by TGFB family members R-HSA-9006936 4.728342e-01 0.325 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.104756e-01 0.508 0 0
Sensory processing of sound R-HSA-9659379 3.414277e-01 0.467 0 0
Signaling by SCF-KIT R-HSA-1433557 4.511999e-01 0.346 0 0
Signaling by NOTCH2 R-HSA-1980145 4.735659e-01 0.325 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.027284e-01 0.395 0 0
Maturation of nucleoprotein R-HSA-9683610 4.323693e-01 0.364 0 0
Signaling by NTRKs R-HSA-166520 3.663116e-01 0.436 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.782472e-01 0.556 0 0
Interleukin-1 processing R-HSA-448706 2.782472e-01 0.556 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.414063e-01 0.467 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.995347e-01 0.301 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.323693e-01 0.364 0 0
Inositol phosphate metabolism R-HSA-1483249 3.880177e-01 0.411 0 0
Signaling by FGFR in disease R-HSA-1226099 2.828665e-01 0.548 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.577485e-01 0.446 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.359881e-01 0.361 0 0
Specification of primordial germ cells R-HSA-9827857 2.971051e-01 0.527 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.414063e-01 0.467 0 0
SARS-CoV Infections R-HSA-9679506 3.965483e-01 0.402 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 4.995347e-01 0.301 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.804963e-01 0.318 0 0
Neurodegenerative Diseases R-HSA-8863678 4.804963e-01 0.318 0 0
DNA strand elongation R-HSA-69190 4.169105e-01 0.380 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.323693e-01 0.364 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.104756e-01 0.508 0 0
Signaling by Leptin R-HSA-2586552 3.099759e-01 0.509 0 0
IRE1alpha activates chaperones R-HSA-381070 3.778847e-01 0.423 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.134671e-01 0.384 0 0
Transmission across Chemical Synapses R-HSA-112315 5.008301e-01 0.300 1 0
Tight junction interactions R-HSA-420029 5.020374e-01 0.299 0 0
Long-term potentiation R-HSA-9620244 5.020374e-01 0.299 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.020374e-01 0.299 0 0
Interleukin-7 signaling R-HSA-1266695 5.020374e-01 0.299 0 0
Interleukin-1 signaling R-HSA-9020702 5.028695e-01 0.299 0 0
MAPK family signaling cascades R-HSA-5683057 5.063014e-01 0.296 0 0
RET signaling R-HSA-8853659 5.101596e-01 0.292 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.122999e-01 0.290 0 0
Interleukin-17 signaling R-HSA-448424 5.122999e-01 0.290 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.161872e-01 0.287 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.161872e-01 0.287 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 5.161872e-01 0.287 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 5.161872e-01 0.287 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.161872e-01 0.287 0 0
Negative regulation of FLT3 R-HSA-9706369 5.161872e-01 0.287 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.161872e-01 0.287 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.162722e-01 0.287 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.162722e-01 0.287 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.180166e-01 0.286 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.231107e-01 0.281 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.231107e-01 0.281 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.231107e-01 0.281 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.231107e-01 0.281 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.280178e-01 0.277 0 0
Ion channel transport R-HSA-983712 5.313179e-01 0.275 0 0
GPER1 signaling R-HSA-9634597 5.320434e-01 0.274 0 0
Muscle contraction R-HSA-397014 5.365761e-01 0.270 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.366131e-01 0.270 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.387150e-01 0.269 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.410290e-01 0.267 0 0
Signaling by LTK in cancer R-HSA-9842640 5.410290e-01 0.267 0 0
STAT5 Activation R-HSA-9645135 5.410290e-01 0.267 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.410290e-01 0.267 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.410290e-01 0.267 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.410290e-01 0.267 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.410290e-01 0.267 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.410290e-01 0.267 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.410290e-01 0.267 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.410290e-01 0.267 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 5.410290e-01 0.267 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 5.410290e-01 0.267 0 0
Neurofascin interactions R-HSA-447043 5.410290e-01 0.267 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.410290e-01 0.267 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.410290e-01 0.267 0 0
HDL clearance R-HSA-8964011 5.410290e-01 0.267 0 0
Lipid particle organization R-HSA-8964572 5.410290e-01 0.267 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.419104e-01 0.266 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.422467e-01 0.266 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.422467e-01 0.266 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.422467e-01 0.266 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.422467e-01 0.266 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.422467e-01 0.266 0 0
Coenzyme A biosynthesis R-HSA-196783 5.422467e-01 0.266 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 5.422467e-01 0.266 0 0
Cristae formation R-HSA-8949613 5.436847e-01 0.265 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.436847e-01 0.265 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.436847e-01 0.265 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.455181e-01 0.263 0 0
MET promotes cell motility R-HSA-8875878 5.455522e-01 0.263 0 0
DNA Damage Bypass R-HSA-73893 5.475787e-01 0.262 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.521220e-01 0.258 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.557059e-01 0.255 0 0
Nucleotide Excision Repair R-HSA-5696398 5.576388e-01 0.254 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.617012e-01 0.250 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.627423e-01 0.250 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.627423e-01 0.250 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.628626e-01 0.250 0 0
Heme signaling R-HSA-9707616 5.635421e-01 0.249 0 0
Insulin receptor recycling R-HSA-77387 5.637332e-01 0.249 0 0
Inflammasomes R-HSA-622312 5.637332e-01 0.249 0 0
Signaling by ERBB4 R-HSA-1236394 5.645302e-01 0.248 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.656976e-01 0.247 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.673132e-01 0.246 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 5.673132e-01 0.246 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.673132e-01 0.246 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.673132e-01 0.246 0 0
Platelet degranulation R-HSA-114608 5.710806e-01 0.243 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.738879e-01 0.241 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.766783e-01 0.239 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 5.790852e-01 0.237 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.790852e-01 0.237 0 0
Recycling of eIF2:GDP R-HSA-72731 5.790852e-01 0.237 0 0
PTK6 Expression R-HSA-8849473 5.790852e-01 0.237 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.790852e-01 0.237 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.790852e-01 0.237 0 0
VLDL clearance R-HSA-8964046 5.790852e-01 0.237 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.790852e-01 0.237 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.790852e-01 0.237 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.790852e-01 0.237 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.795705e-01 0.237 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.795705e-01 0.237 0 0
Diseases of Immune System R-HSA-5260271 5.795705e-01 0.237 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.795705e-01 0.237 0 0
Platelet calcium homeostasis R-HSA-418360 5.832346e-01 0.234 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.832346e-01 0.234 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.833243e-01 0.234 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.906999e-01 0.229 0 0
Apoptotic factor-mediated response R-HSA-111471 5.913722e-01 0.228 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.913722e-01 0.228 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.926205e-01 0.227 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.926205e-01 0.227 0 0
Regulation of insulin secretion R-HSA-422356 6.000023e-01 0.222 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.021719e-01 0.220 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.021719e-01 0.220 0 0
Activation of BH3-only proteins R-HSA-114452 6.021719e-01 0.220 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.021719e-01 0.220 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.120822e-01 0.213 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.120822e-01 0.213 0 0
HIV Transcription Initiation R-HSA-167161 6.120822e-01 0.213 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.120822e-01 0.213 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.139881e-01 0.212 0 0
phospho-PLA2 pathway R-HSA-111995 6.139881e-01 0.212 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.139881e-01 0.212 0 0
MET receptor recycling R-HSA-8875656 6.139881e-01 0.212 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.139881e-01 0.212 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.139881e-01 0.212 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.139881e-01 0.212 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.139881e-01 0.212 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.139881e-01 0.212 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.139881e-01 0.212 0 0
Sodium/Proton exchangers R-HSA-425986 6.139881e-01 0.212 0 0
Regulation of signaling by CBL R-HSA-912631 6.144185e-01 0.212 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.144185e-01 0.212 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.144185e-01 0.212 0 0
Maturation of nucleoprotein R-HSA-9694631 6.144185e-01 0.212 0 0
Diseases of hemostasis R-HSA-9671793 6.144185e-01 0.212 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.205321e-01 0.207 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.205321e-01 0.207 0 0
Trafficking of AMPA receptors R-HSA-399719 6.205321e-01 0.207 0 0
Downstream signal transduction R-HSA-186763 6.205321e-01 0.207 0 0
Generic Transcription Pathway R-HSA-212436 6.223184e-01 0.206 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.277419e-01 0.202 0 0
Signaling by NOTCH3 R-HSA-9012852 6.350640e-01 0.197 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.364170e-01 0.196 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.364546e-01 0.196 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.364546e-01 0.196 0 0
Creatine metabolism R-HSA-71288 6.364546e-01 0.196 0 0
Signaling by FGFR2 R-HSA-5654738 6.376407e-01 0.195 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.429917e-01 0.192 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 6.459986e-01 0.190 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.459986e-01 0.190 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.459986e-01 0.190 0 0
ARMS-mediated activation R-HSA-170984 6.459986e-01 0.190 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.459986e-01 0.190 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.459986e-01 0.190 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.459986e-01 0.190 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.459986e-01 0.190 0 0
Cellular response to mitochondrial stress R-HSA-9840373 6.459986e-01 0.190 0 0
Developmental Cell Lineages R-HSA-9734767 6.465630e-01 0.189 0 0
Signaling by EGFR R-HSA-177929 6.485914e-01 0.188 0 0
Integrin signaling R-HSA-354192 6.554879e-01 0.183 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.554879e-01 0.183 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.554879e-01 0.183 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.574894e-01 0.182 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.574894e-01 0.182 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.574894e-01 0.182 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.574894e-01 0.182 0 0
ERK/MAPK targets R-HSA-198753 6.574894e-01 0.182 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.574894e-01 0.182 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.574894e-01 0.182 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 6.574894e-01 0.182 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.617975e-01 0.179 0 0
Neuronal System R-HSA-112316 6.618028e-01 0.179 1 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.664612e-01 0.176 0 0
RSV-host interactions R-HSA-9833110 6.718913e-01 0.173 0 0
Striated Muscle Contraction R-HSA-390522 6.720749e-01 0.173 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.720749e-01 0.173 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.720749e-01 0.173 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 6.720749e-01 0.173 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.722364e-01 0.172 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.753564e-01 0.170 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.753564e-01 0.170 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.753564e-01 0.170 0 0
Binding and entry of HIV virion R-HSA-173107 6.753564e-01 0.170 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.753564e-01 0.170 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.753564e-01 0.170 0 0
Pexophagy R-HSA-9664873 6.753564e-01 0.170 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.753564e-01 0.170 0 0
Maturation of spike protein R-HSA-9683686 6.753564e-01 0.170 0 0
Josephin domain DUBs R-HSA-5689877 6.753564e-01 0.170 0 0
Tandem pore domain potassium channels R-HSA-1296346 6.753564e-01 0.170 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.775376e-01 0.169 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.775376e-01 0.169 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.775376e-01 0.169 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.781861e-01 0.169 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.872278e-01 0.163 0 0
Mitophagy R-HSA-5205647 6.880669e-01 0.162 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.880669e-01 0.162 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.880669e-01 0.162 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.928091e-01 0.159 0 0
Mitochondrial biogenesis R-HSA-1592230 6.954013e-01 0.158 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.955490e-01 0.158 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.966180e-01 0.157 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.966180e-01 0.157 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.966180e-01 0.157 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 6.966180e-01 0.157 0 0
Synthesis of DNA R-HSA-69239 7.002124e-01 0.155 0 0
Ca2+ pathway R-HSA-4086398 7.008242e-01 0.154 0 0
PECAM1 interactions R-HSA-210990 7.022811e-01 0.153 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.022811e-01 0.153 0 0
LGI-ADAM interactions R-HSA-5682910 7.022811e-01 0.153 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.022811e-01 0.153 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.022811e-01 0.153 0 0
vRNP Assembly R-HSA-192905 7.022811e-01 0.153 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.022811e-01 0.153 0 0
Synthesis of PI R-HSA-1483226 7.022811e-01 0.153 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.022811e-01 0.153 0 0
Suppression of apoptosis R-HSA-9635465 7.022811e-01 0.153 0 0
Transport of RCbl within the body R-HSA-9758890 7.022811e-01 0.153 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.034665e-01 0.153 0 0
Oncogene Induced Senescence R-HSA-2559585 7.034665e-01 0.153 0 0
Signalling to ERKs R-HSA-187687 7.034665e-01 0.153 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.041504e-01 0.152 0 0
Stimuli-sensing channels R-HSA-2672351 7.093003e-01 0.149 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.113292e-01 0.148 0 0
Aquaporin-mediated transport R-HSA-445717 7.113292e-01 0.148 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.127399e-01 0.147 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.127399e-01 0.147 0 0
Co-stimulation by CD28 R-HSA-389356 7.129156e-01 0.147 0 0
Infectious disease R-HSA-5663205 7.142289e-01 0.146 1 0
Termination of O-glycan biosynthesis R-HSA-977068 7.147532e-01 0.146 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.147532e-01 0.146 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.147532e-01 0.146 0 0
Growth hormone receptor signaling R-HSA-982772 7.147532e-01 0.146 0 0
Glycosphingolipid transport R-HSA-9845576 7.182782e-01 0.144 0 0
Triglyceride catabolism R-HSA-163560 7.182782e-01 0.144 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.182782e-01 0.144 0 0
Signaling by FGFR R-HSA-190236 7.247879e-01 0.140 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.269742e-01 0.138 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.269742e-01 0.138 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.269742e-01 0.138 0 0
Plasmalogen biosynthesis R-HSA-75896 7.269742e-01 0.138 0 0
ERKs are inactivated R-HSA-202670 7.269742e-01 0.138 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.269742e-01 0.138 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.269742e-01 0.138 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.269742e-01 0.138 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.269742e-01 0.138 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.319688e-01 0.136 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.319688e-01 0.136 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.325088e-01 0.135 0 0
UCH proteinases R-HSA-5689603 7.327223e-01 0.135 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.375375e-01 0.132 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.375375e-01 0.132 0 0
IGF1R signaling cascade R-HSA-2428924 7.449714e-01 0.128 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.461664e-01 0.127 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.461664e-01 0.127 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.461664e-01 0.127 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.482924e-01 0.126 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.482924e-01 0.126 0 0
Laminin interactions R-HSA-3000157 7.482924e-01 0.126 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.496206e-01 0.125 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.496206e-01 0.125 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 7.496206e-01 0.125 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 7.496206e-01 0.125 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.496206e-01 0.125 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.496206e-01 0.125 0 0
Regulation of IFNG signaling R-HSA-877312 7.496206e-01 0.125 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.496206e-01 0.125 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.496206e-01 0.125 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.496206e-01 0.125 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.496206e-01 0.125 0 0
Signaling by LTK R-HSA-9842663 7.496206e-01 0.125 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.496206e-01 0.125 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.496206e-01 0.125 0 0
OAS antiviral response R-HSA-8983711 7.496206e-01 0.125 0 0
Estrogen biosynthesis R-HSA-193144 7.496206e-01 0.125 0 0
Interleukin-15 signaling R-HSA-8983432 7.496206e-01 0.125 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.497673e-01 0.125 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.555188e-01 0.122 0 0
Pentose phosphate pathway R-HSA-71336 7.592608e-01 0.120 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.612133e-01 0.118 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.612133e-01 0.118 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.637537e-01 0.117 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.637537e-01 0.117 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.637537e-01 0.117 0 0
TRP channels R-HSA-3295583 7.637537e-01 0.117 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.703898e-01 0.113 0 0
Processing of SMDT1 R-HSA-8949664 7.703898e-01 0.113 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.703898e-01 0.113 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.703898e-01 0.113 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.703898e-01 0.113 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.703898e-01 0.113 0 0
rRNA modification in the mitochondrion R-HSA-6793080 7.703898e-01 0.113 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.703898e-01 0.113 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 7.703898e-01 0.113 0 0
Interleukin-6 signaling R-HSA-1059683 7.703898e-01 0.113 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.703898e-01 0.113 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.718031e-01 0.112 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.718031e-01 0.112 0 0
Generation of second messenger molecules R-HSA-202433 7.718031e-01 0.112 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.722482e-01 0.112 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.722482e-01 0.112 0 0
Nucleotide biosynthesis R-HSA-8956320 7.722482e-01 0.112 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.771473e-01 0.109 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.783832e-01 0.109 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.783832e-01 0.109 0 0
Insulin processing R-HSA-264876 7.783832e-01 0.109 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.783832e-01 0.109 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.803749e-01 0.108 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.838053e-01 0.106 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.838053e-01 0.106 0 0
FLT3 Signaling R-HSA-9607240 7.838053e-01 0.106 0 0
Regulated Necrosis R-HSA-5218859 7.851934e-01 0.105 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 7.894374e-01 0.103 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.894374e-01 0.103 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.894374e-01 0.103 0 0
Hydrolysis of LPC R-HSA-1483115 7.894374e-01 0.103 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.894374e-01 0.103 0 0
cGMP effects R-HSA-418457 7.894374e-01 0.103 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.894374e-01 0.103 0 0
Physiological factors R-HSA-5578768 7.894374e-01 0.103 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.894374e-01 0.103 0 0
HDL assembly R-HSA-8963896 7.894374e-01 0.103 0 0
Signal regulatory protein family interactions R-HSA-391160 7.894374e-01 0.103 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.894374e-01 0.103 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.894374e-01 0.103 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.896776e-01 0.103 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.922126e-01 0.101 0 0
Telomere Extension By Telomerase R-HSA-171319 7.922126e-01 0.101 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.922126e-01 0.101 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.922126e-01 0.101 0 0
Pyroptosis R-HSA-5620971 7.922126e-01 0.101 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.931095e-01 0.101 0 0
Mitochondrial protein degradation R-HSA-9837999 7.937928e-01 0.100 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.952805e-01 0.099 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.952805e-01 0.099 0 0
Translation of Structural Proteins R-HSA-9683701 7.952805e-01 0.099 0 0
Interleukin-1 family signaling R-HSA-446652 7.963932e-01 0.099 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.025634e-01 0.096 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.029499e-01 0.095 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.029499e-01 0.095 0 0
Toll-like Receptor Cascades R-HSA-168898 8.043272e-01 0.095 0 0
Signaling by Erythropoietin R-HSA-9006335 8.052739e-01 0.094 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.052739e-01 0.094 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.052739e-01 0.094 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.052739e-01 0.094 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.069058e-01 0.093 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.069058e-01 0.093 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.069058e-01 0.093 0 0
Translesion synthesis by REV1 R-HSA-110312 8.069058e-01 0.093 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.069058e-01 0.093 0 0
DNA Damage Reversal R-HSA-73942 8.069058e-01 0.093 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.069058e-01 0.093 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.069058e-01 0.093 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.109275e-01 0.091 0 0
Hedgehog 'on' state R-HSA-5632684 8.119952e-01 0.090 0 0
Cardiac conduction R-HSA-5576891 8.158474e-01 0.088 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.167055e-01 0.088 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.175992e-01 0.087 0 0
Interleukin-37 signaling R-HSA-9008059 8.175992e-01 0.087 0 0
Translesion synthesis by POLI R-HSA-5656121 8.229260e-01 0.085 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.229260e-01 0.085 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.229260e-01 0.085 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 8.229260e-01 0.085 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.229260e-01 0.085 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.229260e-01 0.085 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.229260e-01 0.085 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.239895e-01 0.084 0 0
TCR signaling R-HSA-202403 8.265993e-01 0.083 0 0
Amine ligand-binding receptors R-HSA-375280 8.266844e-01 0.083 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.292209e-01 0.081 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.292209e-01 0.081 0 0
Aspartate and asparagine metabolism R-HSA-8963693 8.292209e-01 0.081 0 0
Triglyceride metabolism R-HSA-8979227 8.302053e-01 0.081 0 0
Pyruvate metabolism R-HSA-70268 8.359004e-01 0.078 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.361944e-01 0.078 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.361944e-01 0.078 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.376180e-01 0.077 0 0
Translesion synthesis by POLK R-HSA-5655862 8.376180e-01 0.077 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.376180e-01 0.077 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.376180e-01 0.077 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.376180e-01 0.077 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.376180e-01 0.077 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.376180e-01 0.077 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.376180e-01 0.077 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.376180e-01 0.077 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.376180e-01 0.077 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.401708e-01 0.076 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.401708e-01 0.076 0 0
Hemostasis R-HSA-109582 8.415742e-01 0.075 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.452508e-01 0.073 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.452508e-01 0.073 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.452508e-01 0.073 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.452508e-01 0.073 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.452508e-01 0.073 0 0
Diseases of DNA repair R-HSA-9675135 8.452508e-01 0.073 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.452508e-01 0.073 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.498867e-01 0.071 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.504164e-01 0.070 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.504802e-01 0.070 0 0
G-protein beta:gamma signalling R-HSA-397795 8.504802e-01 0.070 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.504802e-01 0.070 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.504802e-01 0.070 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.510917e-01 0.070 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.510917e-01 0.070 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.510917e-01 0.070 0 0
Glycogen storage diseases R-HSA-3229121 8.510917e-01 0.070 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.510917e-01 0.070 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.510917e-01 0.070 0 0
Catecholamine biosynthesis R-HSA-209905 8.510917e-01 0.070 0 0
Choline catabolism R-HSA-6798163 8.510917e-01 0.070 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.510917e-01 0.070 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.510917e-01 0.070 0 0
Gastrulation R-HSA-9758941 8.533988e-01 0.069 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.538693e-01 0.069 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.542482e-01 0.068 0 0
Neurotransmitter release cycle R-HSA-112310 8.559629e-01 0.068 0 0
Potential therapeutics for SARS R-HSA-9679191 8.583520e-01 0.066 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.601801e-01 0.065 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.601801e-01 0.065 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.615924e-01 0.065 0 0
Gluconeogenesis R-HSA-70263 8.620655e-01 0.064 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.624631e-01 0.064 0 0
Mismatch Repair R-HSA-5358508 8.634482e-01 0.064 0 0
Polo-like kinase mediated events R-HSA-156711 8.634482e-01 0.064 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.634482e-01 0.064 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.634482e-01 0.064 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.634482e-01 0.064 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.634482e-01 0.064 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.634482e-01 0.064 0 0
Dual Incision in GG-NER R-HSA-5696400 8.693007e-01 0.061 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.693007e-01 0.061 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.693007e-01 0.061 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.693007e-01 0.061 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.693007e-01 0.061 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.693007e-01 0.061 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.693007e-01 0.061 0 0
Degradation of CDH1 R-HSA-9766229 8.698548e-01 0.061 0 0
Protein localization R-HSA-9609507 8.724219e-01 0.059 0 0
Signaling by Insulin receptor R-HSA-74752 8.739640e-01 0.059 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.747801e-01 0.058 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.747801e-01 0.058 0 0
Pyrimidine biosynthesis R-HSA-500753 8.747801e-01 0.058 0 0
Translesion Synthesis by POLH R-HSA-110320 8.747801e-01 0.058 0 0
Specification of the neural plate border R-HSA-9834899 8.747801e-01 0.058 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.747801e-01 0.058 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.747801e-01 0.058 0 0
Cellular response to hypoxia R-HSA-1234174 8.753342e-01 0.058 0 0
Azathioprine ADME R-HSA-9748787 8.772530e-01 0.057 0 0
PI3K Cascade R-HSA-109704 8.772530e-01 0.057 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.772530e-01 0.057 0 0
Regulation of Apoptosis R-HSA-169911 8.778711e-01 0.057 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.778711e-01 0.057 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.842752e-01 0.053 0 0
The phototransduction cascade R-HSA-2514856 8.842752e-01 0.053 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.851721e-01 0.053 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.851721e-01 0.053 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.851721e-01 0.053 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.851721e-01 0.053 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.851721e-01 0.053 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.851721e-01 0.053 0 0
Glycogen synthesis R-HSA-3322077 8.851721e-01 0.053 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 8.851721e-01 0.053 0 0
Signaling by NODAL R-HSA-1181150 8.851721e-01 0.053 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.851721e-01 0.053 0 0
Signal transduction by L1 R-HSA-445144 8.851721e-01 0.053 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.859200e-01 0.053 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.859200e-01 0.053 0 0
Adipogenesis R-HSA-9843745 8.876431e-01 0.052 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.878797e-01 0.052 0 0
tRNA processing R-HSA-72306 8.908139e-01 0.050 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.909368e-01 0.050 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.933584e-01 0.049 0 0
Degradation of DVL R-HSA-4641258 8.934747e-01 0.049 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.934747e-01 0.049 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.947023e-01 0.048 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.947023e-01 0.048 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.947023e-01 0.048 0 0
Interferon gamma signaling R-HSA-877300 8.971877e-01 0.047 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.972525e-01 0.047 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.972525e-01 0.047 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.997656e-01 0.046 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.032371e-01 0.044 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.034421e-01 0.044 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.034421e-01 0.044 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.034421e-01 0.044 0 0
Attachment and Entry R-HSA-9694614 9.034421e-01 0.044 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.034421e-01 0.044 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.034421e-01 0.044 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.034421e-01 0.044 0 0
Ribavirin ADME R-HSA-9755088 9.034421e-01 0.044 0 0
Assembly Of The HIV Virion R-HSA-175474 9.034421e-01 0.044 0 0
Stabilization of p53 R-HSA-69541 9.072071e-01 0.042 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.072071e-01 0.042 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.072071e-01 0.042 0 0
G alpha (z) signalling events R-HSA-418597 9.089049e-01 0.041 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.096958e-01 0.041 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.096958e-01 0.041 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.114569e-01 0.040 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.114569e-01 0.040 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.114569e-01 0.040 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.114569e-01 0.040 0 0
Ethanol oxidation R-HSA-71384 9.114569e-01 0.040 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.114569e-01 0.040 0 0
LDL clearance R-HSA-8964038 9.114569e-01 0.040 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.114569e-01 0.040 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.128270e-01 0.040 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.134348e-01 0.039 0 0
Glycogen metabolism R-HSA-8982491 9.134348e-01 0.039 0 0
Interleukin-2 family signaling R-HSA-451927 9.134348e-01 0.039 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.142698e-01 0.039 0 0
Signaling by FGFR1 R-HSA-5654736 9.142698e-01 0.039 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.145238e-01 0.039 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.188069e-01 0.037 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.188069e-01 0.037 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.188069e-01 0.037 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.188069e-01 0.037 0 0
Carnitine shuttle R-HSA-200425 9.188069e-01 0.037 0 0
Syndecan interactions R-HSA-3000170 9.188069e-01 0.037 0 0
Maturation of spike protein R-HSA-9694548 9.192685e-01 0.037 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.192685e-01 0.037 0 0
IRS-mediated signalling R-HSA-112399 9.193456e-01 0.037 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.211379e-01 0.036 0 0
Dual incision in TC-NER R-HSA-6782135 9.241454e-01 0.034 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.241454e-01 0.034 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.255471e-01 0.034 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.255471e-01 0.034 0 0
Complex III assembly R-HSA-9865881 9.255471e-01 0.034 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.255471e-01 0.034 0 0
Interleukin-6 family signaling R-HSA-6783589 9.255471e-01 0.034 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.276534e-01 0.033 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.276534e-01 0.033 0 0
Regulation of beta-cell development R-HSA-186712 9.286822e-01 0.032 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.286822e-01 0.032 0 0
Downstream TCR signaling R-HSA-202424 9.290236e-01 0.032 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.298429e-01 0.032 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.317282e-01 0.031 0 0
Hyaluronan degradation R-HSA-2160916 9.317282e-01 0.031 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.317282e-01 0.031 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.317282e-01 0.031 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.317282e-01 0.031 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.329684e-01 0.030 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.329684e-01 0.030 0 0
Signaling by FGFR4 R-HSA-5654743 9.346254e-01 0.029 0 0
Translation of Structural Proteins R-HSA-9694635 9.353663e-01 0.029 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.370159e-01 0.028 0 0
MET activates PTK2 signaling R-HSA-8874081 9.373965e-01 0.028 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.373965e-01 0.028 0 0
Metalloprotease DUBs R-HSA-5689901 9.373965e-01 0.028 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.373965e-01 0.028 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.373965e-01 0.028 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.373965e-01 0.028 0 0
Urea cycle R-HSA-70635 9.373965e-01 0.028 0 0
PCP/CE pathway R-HSA-4086400 9.389360e-01 0.027 0 0
Surfactant metabolism R-HSA-5683826 9.390978e-01 0.027 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.408366e-01 0.026 0 0
Signaling by PDGF R-HSA-186797 9.408366e-01 0.026 0 0
Platelet homeostasis R-HSA-418346 9.410240e-01 0.026 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.423255e-01 0.026 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.424827e-01 0.026 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.425945e-01 0.026 0 0
Triglyceride biosynthesis R-HSA-75109 9.425945e-01 0.026 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.425945e-01 0.026 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.432786e-01 0.025 0 0
Signaling by FGFR3 R-HSA-5654741 9.432786e-01 0.025 0 0
Signaling by Interleukins R-HSA-449147 9.438308e-01 0.025 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.444415e-01 0.025 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.457232e-01 0.024 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.473611e-01 0.023 0 0
Pyrimidine salvage R-HSA-73614 9.473611e-01 0.023 0 0
Insulin receptor signalling cascade R-HSA-74751 9.478414e-01 0.023 0 0
Thyroxine biosynthesis R-HSA-209968 9.517323e-01 0.021 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.517323e-01 0.021 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.517323e-01 0.021 0 0
Glucagon-type ligand receptors R-HSA-420092 9.517323e-01 0.021 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.517323e-01 0.021 0 0
Formation of the cornified envelope R-HSA-6809371 9.532357e-01 0.021 0 0
Neddylation R-HSA-8951664 9.548646e-01 0.020 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.557406e-01 0.020 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.557406e-01 0.020 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.557406e-01 0.020 0 0
Neurotransmitter clearance R-HSA-112311 9.557406e-01 0.020 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.557406e-01 0.020 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.574236e-01 0.019 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.574236e-01 0.019 0 0
SLC transporter disorders R-HSA-5619102 9.576324e-01 0.019 0 0
Budding and maturation of HIV virion R-HSA-162588 9.594164e-01 0.018 0 0
Cargo concentration in the ER R-HSA-5694530 9.594164e-01 0.018 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.594164e-01 0.018 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.595891e-01 0.018 1 1
Parasitic Infection Pathways R-HSA-9824443 9.608689e-01 0.017 1 0
Leishmania infection R-HSA-9658195 9.608689e-01 0.017 1 0
Parasite infection R-HSA-9664407 9.609759e-01 0.017 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.609759e-01 0.017 0 0
Leishmania phagocytosis R-HSA-9664417 9.609759e-01 0.017 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.616284e-01 0.017 0 0
Cellular response to chemical stress R-HSA-9711123 9.621650e-01 0.017 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.627870e-01 0.016 0 0
HS-GAG degradation R-HSA-2024096 9.627870e-01 0.016 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.644902e-01 0.016 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.644902e-01 0.016 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.658779e-01 0.015 0 0
PI Metabolism R-HSA-1483255 9.666326e-01 0.015 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.668461e-01 0.015 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.687123e-01 0.014 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.687123e-01 0.014 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.687123e-01 0.014 0 0
Heme degradation R-HSA-189483 9.687123e-01 0.014 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.688239e-01 0.014 0 0
ER-Phagosome pathway R-HSA-1236974 9.697717e-01 0.013 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.713113e-01 0.013 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.713113e-01 0.013 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.713113e-01 0.013 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.713113e-01 0.013 0 0
Hyaluronan metabolism R-HSA-2142845 9.713113e-01 0.013 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.713113e-01 0.013 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.713113e-01 0.013 0 0
Signal amplification R-HSA-392518 9.713113e-01 0.013 0 0
Circadian clock R-HSA-9909396 9.714872e-01 0.013 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.736946e-01 0.012 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.736946e-01 0.012 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.736946e-01 0.012 0 0
PERK regulates gene expression R-HSA-381042 9.736946e-01 0.012 0 0
Disease R-HSA-1643685 9.740035e-01 0.011 1 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.744377e-01 0.011 0 0
HS-GAG biosynthesis R-HSA-2022928 9.758801e-01 0.011 0 0
RNA Polymerase III Transcription R-HSA-74158 9.758801e-01 0.011 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.758801e-01 0.011 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.758801e-01 0.011 0 0
GPVI-mediated activation cascade R-HSA-114604 9.758801e-01 0.011 0 0
Dectin-2 family R-HSA-5621480 9.762526e-01 0.010 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.762772e-01 0.010 0 0
Voltage gated Potassium channels R-HSA-1296072 9.778841e-01 0.010 0 0
Degradation of AXIN R-HSA-4641257 9.778841e-01 0.010 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.778841e-01 0.010 0 0
Lysine catabolism R-HSA-71064 9.778841e-01 0.010 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.779425e-01 0.010 0 0
Immune System R-HSA-168256 9.779656e-01 0.010 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.780835e-01 0.010 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.790127e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.790127e-01 0.009 0 0
Peroxisomal protein import R-HSA-9033241 9.795157e-01 0.009 0 0
Extension of Telomeres R-HSA-180786 9.795157e-01 0.009 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.795157e-01 0.009 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.797217e-01 0.009 0 0
Purine salvage R-HSA-74217 9.797217e-01 0.009 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.797217e-01 0.009 0 0
tRNA Aminoacylation R-HSA-379724 9.809798e-01 0.008 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.814067e-01 0.008 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.814067e-01 0.008 0 0
Signaling by ALK R-HSA-201556 9.814067e-01 0.008 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.823422e-01 0.008 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.829518e-01 0.007 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.829518e-01 0.007 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.829518e-01 0.007 0 0
G alpha (s) signalling events R-HSA-418555 9.831813e-01 0.007 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.836096e-01 0.007 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.843686e-01 0.007 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.843686e-01 0.007 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.843686e-01 0.007 0 0
FOXO-mediated transcription R-HSA-9614085 9.855413e-01 0.006 0 0
Intra-Golgi traffic R-HSA-6811438 9.856677e-01 0.006 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.856677e-01 0.006 0 0
Activation of GABAB receptors R-HSA-991365 9.868589e-01 0.006 0 0
GABA B receptor activation R-HSA-977444 9.868589e-01 0.006 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.868589e-01 0.006 0 0
Post-translational protein modification R-HSA-597592 9.869090e-01 0.006 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.870361e-01 0.006 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.879512e-01 0.005 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.879512e-01 0.005 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.879512e-01 0.005 0 0
Metabolism of proteins R-HSA-392499 9.881119e-01 0.005 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.887315e-01 0.005 0 0
Proteasome assembly R-HSA-9907900 9.889527e-01 0.005 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.889527e-01 0.005 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.889527e-01 0.005 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.889527e-01 0.005 0 0
O-linked glycosylation of mucins R-HSA-913709 9.895495e-01 0.005 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.898711e-01 0.004 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.898711e-01 0.004 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.898711e-01 0.004 0 0
Somitogenesis R-HSA-9824272 9.898711e-01 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 9.910154e-01 0.004 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.914852e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.916709e-01 0.004 0 0
Metal ion SLC transporters R-HSA-425410 9.921932e-01 0.003 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.923492e-01 0.003 0 0
PPARA activates gene expression R-HSA-1989781 9.924355e-01 0.003 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.928423e-01 0.003 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.928423e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.929461e-01 0.003 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.932306e-01 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.933693e-01 0.003 0 0
Iron uptake and transport R-HSA-917937 9.938562e-01 0.003 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.939832e-01 0.003 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.939832e-01 0.003 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.939832e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.946858e-01 0.002 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.947271e-01 0.002 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.948197e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.951159e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.951159e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.957482e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.957482e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.957488e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.962750e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.964266e-01 0.002 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.966754e-01 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.969965e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.970192e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.972464e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.972464e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.974321e-01 0.001 1 0
Leishmania parasite growth and survival R-HSA-9664433 9.974321e-01 0.001 1 0
Nucleotide salvage R-HSA-8956321 9.974755e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.974755e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.978782e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.982511e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.983651e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.985012e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.986259e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.988302e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.989414e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.989414e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.989414e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.989414e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.990443e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.991103e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.991835e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.992453e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.992523e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.993025e-01 0.000 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.994240e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.994240e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.994720e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.995563e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.996248e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.996272e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.996367e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.996385e-01 0.000 1 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.996534e-01 0.000 0 0
Keratinization R-HSA-6805567 9.996714e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997083e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997474e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.997513e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.998043e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.998141e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.998332e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998365e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.998898e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999074e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999074e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999222e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999497e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999569e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999577e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999704e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999726e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999770e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999778e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999815e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999865e-01 0.000 1 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999919e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999925e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999929e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999932e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999940e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999957e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999963e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999972e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999976e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999983e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999986e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999990e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999995e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999997e-01 0.000 1 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999998e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999998e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways