PKCD

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A6NMY6 S26 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
O00165 S210 SIGNOR|PSP HAX1 HS1BP1 QVsQEGLGPVLQPQPKSYFKsISVTKITKPDGIVEERRTVV
O00429 S616 SIGNOR|PSP DNM1L DLP1 DRP1 SKAEELLAEEKsKPIPIMPAsPQKGHAVNLLDVPVPVARKL
O14939 T566 SIGNOR|PSP PLD2 VVHGLPARDLARHFIQRWNFtKTTKAKYKTPTYPYLLPKST
O15162 T161 SIGNOR|iPTMNet PLSCR1 FAAEDTDCCTRNCCGPSRPFtLRIIDNMGQEVITLERPLRC
O15350 S289 GPS6|SIGNOR|PSP TP73 P73 RPILIIITLEMRDGQVLGRRsFEGRICACPGRDRKADEDHY
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O76090 S358 SIGNOR|PSP BEST1 VMD2 WNKPEPQPPYTAASAQFRRAsFMGSTFNISLNKEEMEFQPN
O95544 S46 PSP NADK CHGDETWSYNHPIRGRAKsRsLsAsPALGsTKEFRRtRsLH
O95544 S64 PSP NADK sRsLsAsPALGsTKEFRRtRsLHGPCPVTTFGPKACVLQNP
O95817 S187 SIGNOR|PSP BAG3 BIS GPERsQsPAAsDCsssSsSAsLPssGRssLGsHQLPRGyIS
P00533 T678 SIGNOR|iPTMNet|PSP EGFR ERBB ERBB1 HER1 LVVALGIGLFMRRRHIVRKRtLRRLLQERELVEPLtPsGEA
P02545 S22 PSP LMNA LMN1 ETPsQRRAtRsGAQAsstPLsPtRItRLQEKEDLQELNDRL
P04040 S167 SIGNOR|PSP CAT GNNTPIFFIRDPILFPSFIHsQKRNPQTHLKDPDMVWDFWS
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 PSP GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T246 PSP GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04637 S46 SIGNOR|PSP TP53 P53 LPENNVLsPLPsQAMDDLMLsPDDIEQWFtEDPGPDEAPRM
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05107 S745 GPS6|SIGNOR|ELM|PSP ITGB2 CD18 MFI7 ALIHLSDLREyRRFEKEKLKsQWNNDNPLFKsAtttVMNPK
P05107 T758 GPS6|SIGNOR|ELM|PSP ITGB2 CD18 MFI7 FEKEKLKsQWNNDNPLFKsAtttVMNPKFAES_________
P05198 S52 SIGNOR|iPTMNet EIF2S1 EIF2A AYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNECVV
P05230 S131 PSP FGF1 FGFA TYISKKHAEKNWFVGLKKNGsCKRGPRTHYGQKAILFLPLP
P05787 S74 GPS6|SIGNOR|ELM|PSP KRT8 CYK8 YGGASGMGGITAVtVNQSLLsPLVLEVDPNIQAVRTQEKEQ
P06401 S400 PSP PGR NR3C3 FQPPALKIKEEEEGAEASARsPRSYLVAGANPAAFPDFPLG
P07108 T42 SIGNOR DBI DEEMLFIyGHyKQAtVGDINtERPGMLDFTGKAKWDAWNEL
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07355 S26 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
P07550 S261 SIGNOR|iPTMNet ADRB2 ADRB2R B2AR HVQNLsQVEQDGRTGHGLRRssKFCLKEHKALKTLGIIMGT
P07550 S262 SIGNOR|iPTMNet ADRB2 ADRB2R B2AR VQNLsQVEQDGRTGHGLRRssKFCLKEHKALKTLGIIMGTF
P07550 S345 SIGNOR|iPTMNet ADRB2 ADRB2R B2AR IyCRSPDFRIAFQELLCLRRssLKAyGNGyssNGNtGEQsG
P07550 S346 SIGNOR|iPTMNet ADRB2 ADRB2R B2AR yCRSPDFRIAFQELLCLRRssLKAyGNGyssNGNtGEQsGY
P08581 S985 GPS6|ELM|PSP MET GsELVRYDARVHtPHLDRLVsARsVsPttEMVsNEsVDyRA
P08913 S247 SIGNOR|iPTMNet ADRA2A ADRA2R ADRAR MILVYVRIYQIAKRRTRVPPsRRGPDAVAAPPGGTERRPNG
P09001 Y265 Sugiyama MRPL3 MRL3 RPML3 TGDIGRVWPGTKMPGKMGNIyRTEYGLKVWRINTKHNIIYV
P09758 S322 SIGNOR|PSP TACSTD2 GA733-1 M1S1 TROP2 KsGKYKKVEIKELGELRKEPsL___________________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10415 S70 PSP BCL2 SSQPGHtPHPAASRDPVARtsPLQtPAAPGAAAGPALsPVP
P10588 S83 SIGNOR|PSP NR2F6 EAR2 ERBAL2 SSGKHYGVFTCEGCKSFFKRsIRRNLSYTCRSNRDCQIDQH
P11413 S180 SIGNOR G6PD sQIGWNRIIVEKPFGRDLQSsDRLsNHIssLFREDQIYRID
P11413 T236 SIGNOR G6PD FANRIFGPIWNRDNIACVILtFKEPFGTEGRGGyFDEFGII
P12830 T790 SIGNOR|PSP CDH1 CDHE UVO sQLHRGLDARPEVTRNDVAPtLMsVPRyLPRPANPDEIGNF
P12931 S12 SIGNOR|PSP SRC SRC1 _________MGSNKSKPKDAsQRRRsLEPAENVHGAGGGAF
P13498 T147 SIGNOR|PSP CYBA RGEQWTPIEPKPRERPQIGGtIKQPPsNPPPRPPAEARKKP
P13796 S5 PSP LCP1 PLS2 ________________MARGsVsDEEMMELREAFAKVDtDG
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14598 S303 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A sGQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDA
P14598 S304 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A GQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDAY
P14598 S315 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A KRGAPPRRssIRNAHsIHQRsRKRLsQDAYRRNsVRFLQQR
P14598 S320 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A PRRssIRNAHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQAR
P14598 S328 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A AHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQARPGPQsPGs
P14598 S348 SIGNOR|PSP NCF1 NOXO2 SH3PXD1A sVRFLQQRRRQARPGPQsPGsPLEEERQtQRsKPQPAVPPR
P14598 S359 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A ARPGPQsPGsPLEEERQtQRsKPQPAVPPRPsADLILNRCs
P14598 S370 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A LEEERQtQRsKPQPAVPPRPsADLILNRCsESTKRKLASAV
P14598 S379 GPS6|SIGNOR|PSP NCF1 NOXO2 SH3PXD1A sKPQPAVPPRPsADLILNRCsESTKRKLASAV_________
P15407 T217 PSP FOSL1 FRA1 RPVPCISLSPGPVLEPEALHtPTLMTtPSLtPFtPSLVFTY
P15407 T227 PSP FOSL1 FRA1 GPVLEPEALHtPTLMTtPSLtPFtPSLVFTYPStPEPCASA
P15941 T1224 GPS6|SIGNOR|ELM|PSP MUC1 PUM HPMsEyPtyHtHGRyVPPsstDRsPyEKVsAGNGGssLsyt
P15941 T224 iPTMNet MUC1 PUM TRPAPGSTAPPAHGVTSAPDtRPAPGSTAPPAHGVTSAPDT
P17096 S44 SIGNOR HMGA1 HMGIY RGRGRPRKQPPVsPGtALVGsQKEPsEVPtPKRPRGRPKGs
P17096 S64 SIGNOR HMGA1 HMGIY sQKEPsEVPtPKRPRGRPKGsKNKGAAKTRKTTTtPGRKPR
P17405 S510 SIGNOR|PSP SMPD1 ASM YIGLNPGYRVYQIDGNYSGSsHVVLDHETYILNLTQANIPG
P18433 S189 SIGNOR PTPRA PTPA PTPRL2 IIVLYMLRFKKYKQAGSHSNsFRLSNGRtEDVEPQsVPLLA
P18433 S204 iPTMNet PTPRA PTPA PTPRL2 GSHSNsFRLSNGRtEDVEPQsVPLLARsPstNRKYPPLPVD
P18433 S213 SIGNOR PTPRA PTPA PTPRL2 SNGRtEDVEPQsVPLLARsPstNRKYPPLPVDKLEEEINRR
P19086 S16 iPTMNet GNAZ _____MGCRQSSEEKEAARRsRRIDRHLRSEsQRQRREIKL
P19086 S27 SIGNOR|iPTMNet GNAZ SEEKEAARRsRRIDRHLRSEsQRQRREIKLLLLGTSNSGKS
P19429 S23 SIGNOR|PSP TNNI3 TNNC1 DGSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsA
P19429 S24 SIGNOR|PSP TNNI3 TNNC1 GSSDAAREPRPAPAPIRRRssNyRAYAtEPHAKKKsKIsAs
P19429 T143 SIGNOR|PSP TNNI3 TNNC1 TEIADLtQKIFDLRGKFKRPtLRRVRIsADAMMQALLGARA
P19634 S648 PSP SLC9A1 APNH1 NHE1 EEEIRKILRNNLQKTRQRLRsyNRHtLVADPyEEAWNQMLL
P21730 S334 SIGNOR|PSP C5AR1 C5AR C5R1 sLPsLLRNVLTEEsVVREsKsFTRsTVDTMAQKTQAV____
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23396 S6 SIGNOR|PSP RPS3 OK/SW-cl.26 _______________MAVQIsKKRKFVADGIFKAELNEFLt
P23396 T221 SIGNOR|PSP RPS3 OK/SW-cl.26 KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P25098 S29 SIGNOR|iPTMNet GRK2 ADRBK1 BARK BARK1 ADVSyLMAMEKSKATPAARAsKKILLPEPSIRSVMQKYLED
P26010 T783 SIGNOR|iPTMNet ITGB7 KEQQQLNWKQDsNPLYKSAItttINPRFQEADSPTL_____
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P28329 S558 SIGNOR CHAT ALQLAFYRLHRRLVPTYESAsIRRFQEGRVDNIRSAtPEAL
P28329 S594 SIGNOR CHAT tPEALAFVRAVTDHKAAVPAsEKLLLLKDAIRAQTAYTVMA
P29353 S139 SIGNOR SHC1 SHC SHCA GRRTRVEGGQLGGEEWTRHGsFVNKPTRGWLHPNDKVMGPG
P29353 S28 SIGNOR SHC1 SHC SHCA PKYNPLRNESLSSLEEGASGsTPPEELPsPSASSLGPILPP
P29474 T495 SIGNOR NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29966 S159 SIGNOR MARCKS MACS PRKCSL EDGAtPsPsNEtPKKKKKRFsFKKsFKLsGFsFKKNKKEAG
P29966 S163 SIGNOR MARCKS MACS PRKCSL tPsPsNEtPKKKKKRFsFKKsFKLsGFsFKKNKKEAGEGGE
P29966 S170 SIGNOR MARCKS MACS PRKCSL tPKKKKKRFsFKKsFKLsGFsFKKNKKEAGEGGEAEAPAAE
P30086 S153 GPS6|SIGNOR|ELM|iPTMNet|PSP PEBP1 PBP PEBP CDEPILsNRsGDHRGKFKVAsFRKKyELRAPVAGtCyQAEW
P30273 S69 PSP FCER1G QVRKAAITSyEKsDGVytGLsTRNQEtyEtLKHEKPPQ___
P30411 S373 SIGNOR|iPTMNet BDKRB2 BKR2 KGGCRSEPIQMENsMGTLRTsIsVERQIHKLQDWAGSRQ__
P31431 S179 SIGNOR|iPTMNet SDC4 LFAVFLILLLMYRMKKKDEGsyDLGKKPIYKKAPTNEFyA_
P31946 S60 GPS6|SIGNOR|ELM YWHAB NEERNLLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQM
P35222 S715 SIGNOR|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 DLGLDIGAQGEPLGYRQDDPsyRsFHSGGYGQDALGMDPMM
P35236 S246 SIGNOR PTPN7 KECPEYTVRQLTIQYQEERRsVKHILFSAWPDHQTPESAGP
P35568 S1101 SIGNOR|iPTMNet IRS1 RNQSAKVIRADPQGCRRRHssEtFsstPSATRVGNTVPFGA
P35568 S307 GPS6|ELM|PSP IRS1 HHLNNPPPSQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVR
P35568 S323 SIGNOR|PSP IRS1 sRtEsItAtsPAsMVGGKPGsFRVRAssDGEGtMsRPAsVD
P35568 S441 PSP IRS1 SDGGFISSDEYGSSPCDFRSsFRsVtPDsLGHtPPARGEEE
P35568 S574 GPS6|ELM|PSP IRS1 MMPAYPPGGGSGGRLPGHRHsAFVPTRSYPEEGLEMHPLER
P35568 S616 SIGNOR IRS1 GGHHRPDsstLHtDDGyMPMsPGVAPVPSGRKGsGDyMPMs
P35611 S726 PSP ADD1 ADDA GsDGSPGKSPsKKKKKFRtPsFLKKSKKKSDS_________
P35612 S713 SIGNOR|iPTMNet ADD2 ADDB sPEGsPsKsPsKKKKKFRTPsFLKKSKKKEKVEs_______
P35612 S726 SIGNOR|iPTMNet ADD2 ADDB KKKFRTPsFLKKSKKKEKVEs____________________
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40189 T890 GPS6|SIGNOR|ELM|iPTMNet|PSP IL6ST EVSAADAFGPGTEGQVERFEtVGMEAATDEGMPKSyLPQtV
P40189 T909 SIGNOR|iPTMNet IL6ST EtVGMEAATDEGMPKSyLPQtVRQGGyMPQ___________
P40763 S727 GPS6|SIGNOR|ELM|PSP STAT3 APRF KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P41143 S344 SIGNOR|iPTMNet OPRD1 OPRD NFKRCFRQLCRKPCGRPDPSsFSRAREATARERVtACtPsD
P41594 S840 SIGNOR|iPTMNet GRM5 GPRC1E MGLUR5 PKVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSS
P41594 T841 SIGNOR GRM5 GPRC1E MGLUR5 KVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSSS
P42224 S727 SIGNOR|PSP STAT1 IsVsEVHPSRLQttDNLLPMsPEEFDEVSRIVGsVEFDSMM
P46060 S24 Sugiyama RANGAP1 KIAA1835 SD EDIAKLAETLAKTQVAGGQLsFKGKSLKLNTAEDAKDVIKE
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48048 S183 iPTMNet KCNJ1 ROMK1 QSILGVIINSFMCGAILAKIsRPKKRAKtItFSKNAVIsKR
P48050 T53 GPS6|ELM KCNJ4 IRK3 ANLSNKSQRYMADIFTTCVDtRWRYMLMIFSAAFLVSWLFF
P49815 S932 SIGNOR|PSP TSC2 TSC4 ITKGLRSNVLLsFDDtPEKDsFRARsTsLNERPKSLRIARP
P49815 S939 SIGNOR|PSP TSC2 TSC4 NVLLsFDDtPEKDsFRARsTsLNERPKSLRIARPPKQGLNN
P49840 S21 SIGNOR|iPTMNet|PSP GSK3A MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49841 S9 PSP GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P51398 S185 PSP DAP3 MRPS29 CRDLLQSSYNKQRFDQPLEAstWLKNFKTTNERFLNQIKVQ
P51398 S280 PSP DAP3 MRPS29 VAVDGINALWGRTTLKREDKsPIAPEELALVHNLRKMMKND
P51398 S31 PSP DAP3 MRPS29 SRIHKLDPGRFLHMGTQARQsIAAHLDNQVPVEsPRAISRT
P51398 T186 PSP DAP3 MRPS29 RDLLQSSYNKQRFDQPLEAstWLKNFKTTNERFLNQIKVQE
P51398 T237 SIGNOR|PSP DAP3 MRPS29 EKGsPLGEVVEQGITRVRNAtDAVGIVLKELKRQssLGMFH
P52757 S171 SIGNOR|PSP CHN2 ARHGAP3 BCH PIyEHIGYATLLREKVsRRLsRsKNEPRKTNVTHEEHTAVE
P53004 S21 SIGNOR|PSP BLVRA BLVR BVR MNAEPERKFGVVVVGVGRAGsVRMRDLRNPHPsSAFLNLIG
P53004 S230 PSP BLVRA BLVR BVR KsPLSWIEEKGPGLKRNRyLsFHFKsGsLENVPNVGVNKNI
P53004 S237 SIGNOR|PSP BLVRA BLVR BVR EEKGPGLKRNRyLsFHFKsGsLENVPNVGVNKNIFLKDQNI
P53004 S33 SIGNOR|PSP BLVRA BLVR BVR VVGVGRAGsVRMRDLRNPHPsSAFLNLIGFVSRRELGSIDG
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396 S656 Sugiyama ACLY IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR
P53671 S283 GPS6|SIGNOR|ELM|PSP LIMK2 PHALSTLDTKENLEGtLRRRsLRRsNsIsKsPGPssPKEPL
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58753 Y106 PSP TIRAP MAL yDVCVCHSEEDLVAAQDLVSyLEGSTASLRCFLQLRDATPG
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P61073 S324 SIGNOR|PSP CXCR4 FLGAKFKtsAQHALtsVsRGssLKILsKGKRGGHssVstEs
P61073 S325 SIGNOR|PSP CXCR4 LGAKFKtsAQHALtsVsRGssLKILsKGKRGGHssVstEsE
P61073 S338 SIGNOR CXCR4 tsVsRGssLKILsKGKRGGHssVstEsEsssFHss______
P61073 S339 SIGNOR CXCR4 sVsRGssLKILsKGKRGGHssVstEsEsssFHss_______
P61254 S9 Sugiyama RPL26 ____________MKFNPFVtsDRsKNRKRHFNAPsHIRRKI
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61513 S21 Sugiyama RPL37A MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQHAKYTCSF
P61513 Y14 Sugiyama RPL37A _______MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQH
P61927 S50 Sugiyama RPL37 QKSTCGKCGYPAKRKRKYNWsAKAKRRNTTGTGRMRHLKIV
P61978 S284 GPS6|ELM HNRNPK HNRPK MPPGRGGRPMPPSRRDyDDMsPRRGPPPPPPGRGGRGGsRA
P61978 S302 GPS6|SIGNOR|ELM|iPTMNet|PSP HNRNPK HNRPK DMsPRRGPPPPPPGRGGRGGsRARNLPLPPPPPPRGGDLMA
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62753 S235 PSP RPS6 OK/SW-cl.2 KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______
P62753 S236 PSP RPS6 OK/SW-cl.2 RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63104 S58 SIGNOR|iPTMNet YWHAZ NEERNLLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQM
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68104 T432 SIGNOR|iPTMNet|Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68431 T46 SIGNOR|Sugiyama H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P78536 T735 PSP ADAM17 CSVP TACE MLSSMDSASVRIIKPFPAPQtPGRLQPAPVIPSAPAAPKLD
P84243 T46 Sugiyama H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P98082 S24 SIGNOR|iPTMNet|PSP DAB2 DOC2 EVEtSATNGQPDQQAAPKAPsKKEKKKGPEKTDEyLLARFK
Q00535 T77 SIGNOR|PSP CDK5 CDKN5 PSSALRE ELKHKNIVRLHDVLHSDKKLtLVFEFCDQDLKKYFDSCNGD
Q01543 T312 GPS6|SIGNOR|PSP FLI1 SDSANASCITWEGTNGEFKMtDPDEVARRWGERKSKPNMNY
Q01995 S181 SIGNOR|iPTMNet TAGLN SM22 WS3-10 REFtEsQLQEGKHVIGLQMGsNRGAsQAGMTGYGRPRQIIS
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q05655 S215 Sugiyama PRKCD PKCD AIHKKCIDKIIGRCTGTAANsRDtIFQKERFNIDMPHRFKV
Q05655 S299 GPS6|SIGNOR|EPSD|PSP|Sugiyama PRKCD PKCD LCGINQKLLAEALNQVtQRAsRRsDsAssEPVGIyQGFEKK
Q05655 S302 GPS6|SIGNOR|EPSD|PSP PRKCD PKCD INQKLLAEALNQVtQRAsRRsDsAssEPVGIyQGFEKKTGV
Q05655 S304 GPS6|SIGNOR|EPSD|PSP|Sugiyama PRKCD PKCD QKLLAEALNQVtQRAsRRsDsAssEPVGIyQGFEKKTGVAG
Q05655 S307 Sugiyama PRKCD PKCD LAEALNQVtQRAsRRsDsAssEPVGIyQGFEKKTGVAGEDM
Q05655 S331 Sugiyama PRKCD PKCD GIyQGFEKKTGVAGEDMQDNsGtyGKIWEGSsKCNINNFIF
Q05655 S503 GPS6|SIGNOR|PSP PRKCD PKCD RDGHIKIADFGMCKENIFGEsRAstFCGtPDyIAPEILQGL
Q05655 S631 Sugiyama PRKCD PKCD LEKRRLEPPFRPKVKsPRDysNFDQEFLNEKARLsysDKNL
Q05655 S645 SIGNOR|iPTMNet|PSP PRKCD PKCD KsPRDysNFDQEFLNEKARLsysDKNLIDsMDQsAFAGFsF
Q05655 T141 GPS6|SIGNOR|PSP PRKCD PKCD FLEDVDCKQsMRSEDEAKFPtMNRRGAIKQAKIHyIKNHEF
Q05655 T218 GPS6|SIGNOR|PSP|Sugiyama PRKCD PKCD KKCIDKIIGRCTGTAANsRDtIFQKERFNIDMPHRFKVHNY
Q05655 T295 GPS6|SIGNOR|PSP|Sugiyama PRKCD PKCD KVANLCGINQKLLAEALNQVtQRAsRRsDsAssEPVGIyQG
Q05655 T333 Sugiyama PRKCD PKCD yQGFEKKTGVAGEDMQDNsGtyGKIWEGSsKCNINNFIFHK
Q05655 T507 SIGNOR PRKCD PKCD IKIADFGMCKENIFGEsRAstFCGtPDyIAPEILQGLKyTF
Q05655 T58 Sugiyama PRKCD PKCD TERGKTLVQKKPTMyPEWKStFDAHIyEGRVIQIVLMRAAE
Q09472 S89 GPS6|SIGNOR|ELM|iPTMNet|PSP EP300 P300 GMVQDAASKHKQLSELLRsGssPNLNMGVGGPGQVMAsQAQ
Q12965 T935 Sugiyama MYO1E MYO1C VLQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAA
Q12965 Y941 Sugiyama MYO1E MYO1C GPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAPPPPGy
Q13263 S473 SIGNOR TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13501 S349 PSP SQSTM1 ORCA OSIL DNCsGGDDDWtHLssKEVDPstGELQsLQMPEsEGPssLDP
Q13887 S153 SIGNOR|iPTMNet KLF5 BTEB2 CKLF IKLF SINMNVFLPDITHLRTGLYKsQRPCVTHIKTEPVAIFSHQS
Q14247 S405 SIGNOR|PSP CTTN EMS1 EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14247 S418 SIGNOR CTTN EMS1 KtQtPPVsPAPQPtEERLPssPVyEDAAsFKAELsyRGPVs
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14896 S275 SIGNOR MYBPC3 TVHEAMGTGDLDLLSAFRRTsLAGGGRRIsDSHEDTGILDF
Q14896 S284 SIGNOR MYBPC3 DLDLLSAFRRTsLAGGGRRIsDSHEDTGILDFSSLLKKRDs
Q14896 S304 SIGNOR MYBPC3 sDSHEDTGILDFSSLLKKRDsFRTPRDsKLEAPAEEDVWEI
Q15080 S315 PSP NCF4 SH3PXD4 VRLLSDEDVALMVRQARGLPsQKRLFPWKLHITQKDNYRVY
Q15080 T154 SIGNOR|iPTMNet|PSP NCF4 SH3PXD4 YQSPYDSEQVPQALRRLRPRtRKVKsVsPQGNsVDRMAAPR
Q15139 S412 PSP PRKD1 PKD PKD1 PRKCM ANRtIsPstsNNIPLMRVVQsVKHTKRKSsTVMKEGWMVHy
Q15139 S738 GPS6|SIGNOR|ELM|PSP PRKD1 PKD PKD1 PRKCM DPFPQVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNK
Q15139 S742 GPS6|SIGNOR|ELM|PSP PRKD1 PKD PKD1 PRKCM QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNR
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15438 S394 SIGNOR|iPTMNet CYTH1 D17S811E PSCD1 AAISRDPFYEMLAARKKKVSstKRH________________
Q15438 T395 SIGNOR|iPTMNet CYTH1 D17S811E PSCD1 AISRDPFYEMLAARKKKVSstKRH_________________
Q15717 S221 SIGNOR|PSP ELAVL1 HUR HsPARRFGGPVHHQAQRFRFsPMGVDHMSGLSGVNVPGNAS
Q15717 S318 SIGNOR|PSP ELAVL1 HUR AAMAIAsLNGYRLGDKILQVsFKTNKSHK____________
Q16206 S504 SIGNOR|PSP ENOX2 COVA1 KLKDDKLQVEKMLENLKEKEsCASRLCASNQDSEYPLEKTM
Q16236 S40 SIGNOR|iPTMNet|PSP NFE2L2 NRF2 IDILWRQDIDLGVSREVFDFsQRRKEYELEKQKKLEKERQE
Q16658 S39 SIGNOR|iPTMNet FSCN1 FAN1 HSN SNL CGNKyLTAEAFGFKVNASAssLKKKQIWTLEQPPDEAGSAA
Q16695 T46 Sugiyama H3-4 H3FT HIST3H3 ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q16820 S687 SIGNOR|iPTMNet MEP1B MLIITLVSVYCTRKKYRERMsSNRPNLTPQNQHAF______
Q5JVS0 T354 SIGNOR|iPTMNet HABP4 MVKDDYEDDSHVFRKPANDItSQLEINFGNLPRPGRGARGG
Q5JVS0 T375 SIGNOR|iPTMNet HABP4 SQLEINFGNLPRPGRGARGGtRGGRGRIRRAENYGPRAEVV
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6NXT2 T45 Sugiyama H3-5 H3F3C AARKSTPSTCGVKPHRyRPGtVALREIRRYQKstELLIRKL
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q71DI3 T46 Sugiyama H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q7KZI7 T596 GPS6|PSP MARK2 EMK1 sssGGAPDRTNFPRGVssRstFHAGQLRQVRDQQNLPyGVt
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IV61 T133 PSP RASGRP3 GRP3 KIAA0846 KHVSLIDISSIPSYDWMRRVtQRKKVSKKGKACLLFDHLEP
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IXH6 S208 Sugiyama TP53INP2 C20orf110 DOR PINH AVQRQNRARESRPRRSKNQSsFIyQPCQRQFNY________
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N6T7 T294 GPS6 SIRT6 SIR2L6 PAWDGPRVLERALPPLPRPPtPKLEPKEEsPtRINGSIPAG
Q8NE86 S92 PSP MCU C10orf42 CCDC109A SDDVTVVYQNGLPVISVRLPsRRERCQFTLKPISDSVGVFL
Q8TCJ0 S178 SIGNOR|PSP FBXO25 FBX25 KVLDDHHNPRLIKDLLQDLSsTLCILIRGVGKSVLVGNINI
Q8TCU6 S313 PSP PREX1 KIAA1415 LFDNLLVYCKRKSRVTGSKKsTKRTKsINGSLYIFRGRINT
Q92793 S437 SIGNOR|iPTMNet CREBBP CBP SHWKNCTRHDCPVCLPLKNAsDKRNQQTILGSPASGIQNTI
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96A00 T38 PSP PPP1R14A CPI17 PPP1INL SRARGPGGsPGGLQKRHARVtVKYDRRELQRRLDVEKWIDG
Q96C90 T57 SIGNOR|PSP PPP1R14B PLCB3N PNG AGEGPGGADDEGPVRRQGKVtVKYDRKELRKRLNLEEWILE
Q96D96 S97 GPS6|PSP HVCN1 VSOP UNQ578/PRO1140 APGPAPRAPLDFRGMLRKLFsSHRFQVIIICLVVLDALLVL
Q96D96 T10 SIGNOR HVCN1 VSOP UNQ578/PRO1140 ___________MATWDEKAVtRRAKVAPAERMSKFLRHFtV
Q96D96 T29 GPS6|PSP HVCN1 VSOP UNQ578/PRO1140 VtRRAKVAPAERMSKFLRHFtVVGDDYHAWNINYKKWENEE
Q99808 S281 SIGNOR|PSP SLC29A1 ENT1 AGKEEsGVsVsNsQPTNESHsIKAILKNISVLAFSVCFIFT
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZK7 S123 SIGNOR|PSP TBL1XR1 IRA1 TBLR1 LAQQQAAAAAAAAAAAsQQGsAKNGENTANGEENGAHTIAN
Q9H257 T231 PSP CARD9 DQLKHSLMKAEDDCKVERKHtLKLRHAMEQRPSQELLWELQ
Q9HBA0 S162 PSP TRPV4 VRL2 VROAC PPPILKVFNRPILFDIVSRGsTADLDGLLPFLLtHKKRLTD
Q9HBA0 S189 PSP TRPV4 VRL2 VROAC LLPFLLtHKKRLTDEEFREPsTGKTCLPKALLNLSNGRNDT
Q9HBA0 T175 PSP TRPV4 VRL2 VROAC FDIVSRGsTADLDGLLPFLLtHKKRLTDEEFREPsTGKTCL
Q9NQ66 S887 iPTMNet PLCB1 KIAA0581 TTTLTPKPPSQALHSQPAPGsVKAPAKTEDLIQSVLTEVEA
Q9NRY6 T21 SIGNOR|PSP PLSCR3 MAGYLPPKGYAPSPPPPYPVtPGYPEPALHPGPGQAPVPAQ
Q9UBP9 T35 GPS6 GULP1 CED6 GULP HTPEALSKHFIPYNAKFLGStEVEQPKGTEVVRDAVRKLKF
Q9UBS0 S473 GPS6|SIGNOR|ELM|PSP RPS6KB2 STK14B PPPPSTTAPLPIRPPSGTKKsKRGRGRPGR___________
Q9UGV2 S333 Sugiyama NDRG3 MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UNX3 S9 Sugiyama RPL26L1 RPL26P1 ____________MKFNPFVtsDRsKNRKRHFNAPSHVRRKI
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ13 S297 SIGNOR|PSP SHOC2 KIAA0862 PDTIGNLSSLSRLGLRYNRLsAIPRSLAKCSALEELNLENN
Q9UQ13 T71 SIGNOR|PSP SHOC2 KIAA0862 KDGKKDSSAAQPGVAFSVDNtIKRPNPAPGTRKKSSNAEVI
Q9UQ80 S360 GPS6|SIGNOR|PSP PA2G4 EBP1 PDLyKsEMEVQDAELKALLQssAsRKtQKKKKKKAsKtAEN
Q9UQL6 S259 SIGNOR|PSP HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 SIGNOR HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9Y2R2 S35 GPS6|SIGNOR|PSP PTPN22 PTPN8 QSKKITKEEFANEFLKLKRQsTKYKADKTYPTTVAEKPKNI
Q9Y6H6 S82 SIGNOR KCNE3 LFVMFLFAVTVGSLILGYTRsRKVDKRSDPYHVYIKNRVSM
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 4.012679e-12 11.397 1 0
Cell Cycle R-HSA-1640170 6.080039e-10 9.216 0 0
Axon guidance R-HSA-422475 4.711026e-09 8.327 0 0
Cellular Senescence R-HSA-2559583 8.067359e-09 8.093 0 0
Nervous system development R-HSA-9675108 1.321781e-08 7.879 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.244873e-08 7.489 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.314450e-08 7.275 0 0
Apoptotic execution phase R-HSA-75153 5.966491e-08 7.224 1 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.444783e-08 7.191 0 0
Cell Cycle, Mitotic R-HSA-69278 7.934368e-07 6.100 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.367188e-06 5.864 1 1
Cell Cycle Checkpoints R-HSA-69620 1.682597e-06 5.774 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.125843e-06 5.672 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.125843e-06 5.672 0 0
G alpha (12/13) signalling events R-HSA-416482 2.358017e-06 5.627 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.080614e-06 5.389 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.830962e-06 5.316 0 0
Mitotic Anaphase R-HSA-68882 5.095416e-06 5.293 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.791909e-06 5.237 0 0
Mitotic Prometaphase R-HSA-68877 5.887429e-06 5.230 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.110990e-06 5.148 0 0
Recycling pathway of L1 R-HSA-437239 9.881345e-06 5.005 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.060166e-05 4.975 0 0
Separation of Sister Chromatids R-HSA-2467813 1.124477e-05 4.949 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.306283e-05 4.884 0 0
Regulation of TP53 Activity R-HSA-5633007 1.281249e-05 4.892 0 0
M Phase R-HSA-68886 1.277219e-05 4.894 0 0
NRAGE signals death through JNK R-HSA-193648 1.292755e-05 4.888 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.503988e-05 4.823 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.788889e-05 4.747 0 0
EPH-Ephrin signaling R-HSA-2682334 2.711066e-05 4.567 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.300740e-05 4.481 0 0
mRNA Splicing R-HSA-72172 5.052919e-05 4.296 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.392960e-05 4.268 0 0
L1CAM interactions R-HSA-373760 5.955657e-05 4.225 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.890225e-05 4.162 0 0
Chromatin organization R-HSA-4839726 6.956467e-05 4.158 0 0
Chromatin modifying enzymes R-HSA-3247509 7.688071e-05 4.114 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.619669e-05 4.065 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.619669e-05 4.065 0 0
Kinesins R-HSA-983189 8.961730e-05 4.048 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.021339e-04 3.991 0 0
Signaling by Hippo R-HSA-2028269 1.203879e-04 3.919 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.372294e-04 3.863 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.480426e-04 3.830 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.975108e-04 3.704 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.138567e-04 3.670 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.189014e-04 3.660 1 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.401284e-04 3.620 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.055648e-04 3.515 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.308533e-04 3.480 0 0
Meiosis R-HSA-1500620 3.296603e-04 3.482 0 0
Interleukin-37 signaling R-HSA-9008059 3.358008e-04 3.474 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.955701e-04 3.403 0 0
Semaphorin interactions R-HSA-373755 4.069981e-04 3.390 0 0
Apoptosis R-HSA-109581 4.227547e-04 3.374 1 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.386070e-04 3.358 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.405532e-04 3.356 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.674108e-04 3.330 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.564698e-04 3.341 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.700898e-04 3.328 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.900989e-04 3.310 0 0
Post NMDA receptor activation events R-HSA-438064 5.346670e-04 3.272 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.689565e-04 3.245 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.281866e-04 3.202 0 0
mRNA 3'-end processing R-HSA-72187 6.647706e-04 3.177 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.882076e-04 3.162 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.701379e-04 3.174 0 0
Intracellular signaling by second messengers R-HSA-9006925 7.242645e-04 3.140 1 0
Meiotic synapsis R-HSA-1221632 8.098732e-04 3.092 0 0
Gap junction trafficking R-HSA-190828 7.926586e-04 3.101 0 0
RMTs methylate histone arginines R-HSA-3214858 7.926586e-04 3.101 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.818577e-04 3.055 0 0
Gap junction trafficking and regulation R-HSA-157858 8.926786e-04 3.049 0 0
Gene expression (Transcription) R-HSA-74160 8.678020e-04 3.062 0 0
Signaling by VEGF R-HSA-194138 9.318284e-04 3.031 1 0
PIP3 activates AKT signaling R-HSA-1257604 9.956055e-04 3.002 0 0
Death Receptor Signaling R-HSA-73887 1.000245e-03 3.000 0 0
Metalloprotease DUBs R-HSA-5689901 1.015079e-03 2.994 0 0
MAP2K and MAPK activation R-HSA-5674135 1.064712e-03 2.973 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.199919e-03 2.921 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.199919e-03 2.921 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.199919e-03 2.921 0 0
HDACs deacetylate histones R-HSA-3214815 1.183288e-03 2.927 0 0
Signaling by RAS mutants R-HSA-6802949 1.199919e-03 2.921 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.146460e-03 2.941 1 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.288812e-03 2.890 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.331682e-03 2.876 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.331682e-03 2.876 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.337532e-03 2.874 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.722187e-03 2.764 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.660394e-03 2.780 0 0
RNA Polymerase II Transcription R-HSA-73857 1.699187e-03 2.770 0 0
Signaling by ALK in cancer R-HSA-9700206 1.660394e-03 2.780 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.771149e-03 2.752 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.772810e-03 2.751 0 0
HATs acetylate histones R-HSA-3214847 1.935801e-03 2.713 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.087382e-03 2.680 0 0
Integrin signaling R-HSA-354192 2.075614e-03 2.683 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.175633e-03 2.662 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.175633e-03 2.662 0 0
DNA methylation R-HSA-5334118 2.205417e-03 2.657 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.206176e-03 2.656 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.280114e-03 2.642 0 0
Programmed Cell Death R-HSA-5357801 2.475116e-03 2.606 1 0
Deubiquitination R-HSA-5688426 2.346740e-03 2.630 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.566087e-03 2.591 0 0
Cellular responses to stimuli R-HSA-8953897 2.570559e-03 2.590 1 0
Diseases of programmed cell death R-HSA-9645723 2.583549e-03 2.588 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.654316e-03 2.576 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.807293e-03 2.552 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.978176e-03 2.526 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.820714e-03 2.550 0 0
Mitotic Prophase R-HSA-68875 2.858083e-03 2.544 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.967888e-03 2.528 0 0
Meiotic recombination R-HSA-912446 3.053337e-03 2.515 0 0
Rap1 signalling R-HSA-392517 3.094954e-03 2.509 0 0
Cellular responses to stress R-HSA-2262752 3.148922e-03 2.502 1 0
Gap junction assembly R-HSA-190861 3.223596e-03 2.492 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.233732e-03 2.490 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.292906e-03 2.482 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.362593e-03 2.473 0 0
Interleukin-12 signaling R-HSA-9020591 3.421439e-03 2.466 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.836575e-03 2.416 0 0
FOXO-mediated transcription R-HSA-9614085 3.671296e-03 2.435 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.930793e-03 2.406 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.957891e-03 2.403 0 0
Oncogene Induced Senescence R-HSA-2559585 3.967479e-03 2.401 0 0
Aggrephagy R-HSA-9646399 4.343218e-03 2.362 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.504281e-03 2.346 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.845139e-03 2.315 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.773357e-03 2.321 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.639431e-03 2.334 0 0
MAPK family signaling cascades R-HSA-5683057 4.930118e-03 2.307 0 0
Selective autophagy R-HSA-9663891 4.989918e-03 2.302 0 0
ESR-mediated signaling R-HSA-8939211 5.198580e-03 2.284 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.372107e-03 2.270 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.372107e-03 2.270 0 0
Nucleosome assembly R-HSA-774815 5.522504e-03 2.258 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.522504e-03 2.258 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.958599e-03 2.225 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.958599e-03 2.225 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.564306e-03 2.183 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.256955e-03 2.204 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.537187e-03 2.185 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.654992e-03 2.177 0 0
Cell-Cell communication R-HSA-1500931 6.482584e-03 2.188 0 0
Ub-specific processing proteases R-HSA-5689880 6.677418e-03 2.175 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.845410e-03 2.165 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.879062e-03 2.162 0 0
Activation of RAC1 R-HSA-428540 6.897722e-03 2.161 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.924630e-03 2.160 1 0
Ephrin signaling R-HSA-3928664 7.196015e-03 2.143 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.261277e-03 2.139 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.532480e-03 2.123 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.451454e-03 2.073 0 0
Nuclear import of Rev protein R-HSA-180746 7.957520e-03 2.099 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.451454e-03 2.073 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.934221e-03 2.100 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.114369e-03 2.091 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.451454e-03 2.073 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.024778e-03 2.096 0 0
Interleukin-12 family signaling R-HSA-447115 8.280995e-03 2.082 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 8.750006e-03 2.058 0 0
Defective pyroptosis R-HSA-9710421 8.796391e-03 2.056 0 0
Interaction between L1 and Ankyrins R-HSA-445095 9.917124e-03 2.004 0 0
Packaging Of Telomere Ends R-HSA-171306 9.917124e-03 2.004 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.917124e-03 2.004 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.003896e-02 1.998 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.003896e-02 1.998 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.003896e-02 1.998 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.067502e-02 1.972 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.080567e-02 1.966 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.143573e-02 1.942 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.092514e-02 1.962 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.080567e-02 1.966 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.187972e-02 1.925 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.189166e-02 1.925 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.189166e-02 1.925 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.189166e-02 1.925 0 0
Metabolism of RNA R-HSA-8953854 1.276860e-02 1.894 1 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.297396e-02 1.887 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.299370e-02 1.886 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.299370e-02 1.886 0 0
Signaling by EGFR R-HSA-177929 1.397089e-02 1.855 0 0
Developmental Biology R-HSA-1266738 1.445783e-02 1.840 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.471164e-02 1.832 0 0
Signaling by Interleukins R-HSA-449147 1.495246e-02 1.825 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.739595e-02 1.760 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.718116e-02 1.765 0 0
Chromosome Maintenance R-HSA-73886 1.600264e-02 1.796 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.596684e-02 1.797 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.551131e-02 1.809 0 0
Generic Transcription Pathway R-HSA-212436 1.625853e-02 1.789 0 0
Cell junction organization R-HSA-446728 1.642870e-02 1.784 0 0
Reproduction R-HSA-1474165 1.573133e-02 1.803 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.598962e-02 1.796 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.761913e-02 1.754 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.767970e-02 1.753 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.836731e-02 1.736 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.836731e-02 1.736 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.836731e-02 1.736 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.852045e-02 1.732 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.860293e-02 1.730 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.872835e-02 1.728 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.890546e-02 1.723 0 0
PKR-mediated signaling R-HSA-9833482 2.016062e-02 1.695 0 0
Metabolism of non-coding RNA R-HSA-194441 2.061588e-02 1.686 0 0
snRNP Assembly R-HSA-191859 2.061588e-02 1.686 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.065622e-02 1.685 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.100723e-02 1.678 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.107172e-02 1.676 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.107172e-02 1.676 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.160759e-02 1.665 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.223790e-02 1.653 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.310464e-02 1.636 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.548879e-02 1.594 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.412693e-02 1.617 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.524526e-02 1.598 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.524526e-02 1.598 0 0
HCMV Early Events R-HSA-9609690 2.379802e-02 1.623 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.498670e-02 1.602 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.435444e-02 1.613 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.456543e-02 1.610 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.456543e-02 1.610 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.420287e-02 1.616 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.621971e-02 1.581 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.710577e-02 1.567 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.711473e-02 1.567 0 0
Diseases of DNA repair R-HSA-9675135 2.856832e-02 1.544 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.888425e-02 1.539 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.906829e-02 1.537 0 0
Signaling by NOTCH R-HSA-157118 2.912125e-02 1.536 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.912779e-02 1.536 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.925257e-02 1.534 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.932762e-02 1.533 0 0
Cleavage of the damaged purine R-HSA-110331 2.932762e-02 1.533 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.008577e-02 1.522 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.008577e-02 1.522 0 0
Signaling by NTRKs R-HSA-166520 3.064997e-02 1.514 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.101639e-02 1.508 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.128485e-02 1.505 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.128485e-02 1.505 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.128485e-02 1.505 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.128485e-02 1.505 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.454373e-02 1.462 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.454373e-02 1.462 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.454373e-02 1.462 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.454373e-02 1.462 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.454373e-02 1.462 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.454373e-02 1.462 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.454373e-02 1.462 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.454373e-02 1.462 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.182540e-02 1.497 0 0
Gap junction degradation R-HSA-190873 3.182540e-02 1.497 0 0
Striated Muscle Contraction R-HSA-390522 3.410011e-02 1.467 0 0
Homology Directed Repair R-HSA-5693538 3.215020e-02 1.493 0 0
Opioid Signalling R-HSA-111885 3.229179e-02 1.491 1 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.385732e-02 1.470 0 0
DNA Repair R-HSA-73894 3.551778e-02 1.450 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.455489e-02 1.461 0 0
Depurination R-HSA-73927 3.385732e-02 1.470 0 0
Signaling by ROBO receptors R-HSA-376176 3.673954e-02 1.435 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.410011e-02 1.467 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.695485e-02 1.432 0 0
Glycolysis R-HSA-70171 3.718603e-02 1.430 0 0
G2/M Transition R-HSA-69275 3.886859e-02 1.410 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.892792e-02 1.410 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.916769e-02 1.407 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.916769e-02 1.407 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.916769e-02 1.407 0 0
HDMs demethylate histones R-HSA-3214842 3.925847e-02 1.406 0 0
Signal amplification R-HSA-392518 3.948823e-02 1.404 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.968479e-02 1.401 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.968479e-02 1.401 0 0
Macroautophagy R-HSA-1632852 3.970016e-02 1.401 0 0
Signaling by NOTCH1 R-HSA-1980143 4.080578e-02 1.389 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.227041e-02 1.374 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.227041e-02 1.374 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.235952e-02 1.373 0 0
Regulation of CDH11 function R-HSA-9762292 4.235952e-02 1.373 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.235952e-02 1.373 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.276133e-02 1.369 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.276133e-02 1.369 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.276133e-02 1.369 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.276133e-02 1.369 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.276133e-02 1.369 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.296995e-02 1.367 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.296995e-02 1.367 0 0
Netrin-1 signaling R-HSA-373752 4.304553e-02 1.366 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.316024e-02 1.365 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.436971e-02 1.353 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.473618e-02 1.349 0 0
Gene Silencing by RNA R-HSA-211000 4.483937e-02 1.348 0 0
Protein folding R-HSA-391251 4.536919e-02 1.343 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.544078e-02 1.343 0 0
Muscle contraction R-HSA-397014 4.610958e-02 1.336 0 0
TRP channels R-HSA-3295583 4.622418e-02 1.335 0 0
MHC class II antigen presentation R-HSA-2132295 4.699102e-02 1.328 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.735322e-02 1.325 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.910384e-02 1.309 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.756603e-02 1.240 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.756603e-02 1.240 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.756603e-02 1.240 0 0
Regulation of PTEN localization R-HSA-8948747 5.895525e-02 1.229 0 0
RET signaling R-HSA-8853659 5.197878e-02 1.284 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.925072e-02 1.308 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.895525e-02 1.229 0 0
Interferon Signaling R-HSA-913531 5.781917e-02 1.238 1 0
Interleukin-2 signaling R-HSA-9020558 5.476226e-02 1.262 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.039217e-02 1.298 0 0
G-protein mediated events R-HSA-112040 4.994923e-02 1.301 1 0
Dopamine receptors R-HSA-390651 5.756603e-02 1.240 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.396628e-02 1.268 0 0
FLT3 Signaling R-HSA-9607240 5.039217e-02 1.298 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.895525e-02 1.229 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 5.912011e-02 1.228 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.045785e-02 1.219 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.045785e-02 1.219 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.103292e-02 1.214 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.103292e-02 1.214 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.103292e-02 1.214 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.103292e-02 1.214 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.103292e-02 1.214 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.169606e-02 1.210 0 0
Neuronal System R-HSA-112316 6.388467e-02 1.195 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.405185e-02 1.193 0 0
Depyrimidination R-HSA-73928 6.405185e-02 1.193 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.413930e-02 1.193 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.449606e-02 1.190 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.561080e-02 1.183 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.623460e-02 1.179 0 0
G2/M Checkpoints R-HSA-69481 6.632613e-02 1.178 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.687927e-02 1.175 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.772291e-02 1.169 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.079690e-02 1.150 0 0
Oligomerization of connexins into connexons R-HSA-190704 7.079690e-02 1.150 0 0
Transport of connexins along the secretory pathway R-HSA-190827 7.079690e-02 1.150 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 7.079690e-02 1.150 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 7.079690e-02 1.150 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 8.247915e-02 1.084 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 8.247915e-02 1.084 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 8.247915e-02 1.084 0 0
Formation of annular gap junctions R-HSA-196025 7.741131e-02 1.111 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.904782e-02 1.161 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.904782e-02 1.161 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.904782e-02 1.161 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.519166e-02 1.070 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.519166e-02 1.070 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.519166e-02 1.070 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.519166e-02 1.070 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.519166e-02 1.070 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.519166e-02 1.070 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.519166e-02 1.070 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 7.324378e-02 1.135 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.430022e-02 1.129 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.430022e-02 1.129 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.488494e-02 1.071 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.488494e-02 1.071 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.488494e-02 1.071 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.953595e-02 1.158 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.203493e-02 1.086 0 0
RAF activation R-HSA-5673000 7.875343e-02 1.104 0 0
Translation initiation complex formation R-HSA-72649 7.163130e-02 1.145 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.889370e-02 1.103 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.029947e-02 1.095 0 0
PTEN Regulation R-HSA-6807070 7.541126e-02 1.123 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.953595e-02 1.158 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.953595e-02 1.158 0 0
DNA Double Strand Break Response R-HSA-5693606 8.396323e-02 1.076 0 0
Telomere Maintenance R-HSA-157579 7.306645e-02 1.136 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.480422e-02 1.126 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.571149e-02 1.121 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.875343e-02 1.104 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.519166e-02 1.070 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.823683e-02 1.166 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.185752e-02 1.087 0 0
Activation of BH3-only proteins R-HSA-114452 8.203493e-02 1.086 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.817985e-02 1.166 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.741131e-02 1.111 0 0
Co-stimulation by CD28 R-HSA-389356 6.817985e-02 1.166 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.077938e-02 1.150 0 0
Cell-cell junction organization R-HSA-421270 7.029195e-02 1.153 0 0
Signaling by NOTCH3 R-HSA-9012852 7.901265e-02 1.102 0 0
TBC/RABGAPs R-HSA-8854214 7.171420e-02 1.144 0 0
Signaling by ALK R-HSA-201556 7.526720e-02 1.123 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.741131e-02 1.111 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.548138e-02 1.068 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.548138e-02 1.068 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.548138e-02 1.068 0 0
Adherens junctions interactions R-HSA-418990 8.569318e-02 1.067 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.686673e-02 1.061 0 0
Sensory processing of sound R-HSA-9659379 8.724844e-02 1.059 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.869064e-02 1.052 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.142229e-02 1.039 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.304581e-02 1.031 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.395428e-02 1.027 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.432297e-02 1.025 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.688465e-02 1.014 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.713741e-02 1.013 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.713741e-02 1.013 0 0
Signaling by TGFBR3 R-HSA-9839373 9.812168e-02 1.008 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 9.839635e-02 1.007 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.928818e-02 1.003 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.006765e-01 0.997 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.346090e-01 0.871 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.346090e-01 0.871 0 0
KIT mutants bind TKIs R-HSA-9669921 1.346090e-01 0.871 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.346090e-01 0.871 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.346090e-01 0.871 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.346090e-01 0.871 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.346090e-01 0.871 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.346090e-01 0.871 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.346090e-01 0.871 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.346090e-01 0.871 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.346090e-01 0.871 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.346090e-01 0.871 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.346090e-01 0.871 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.346090e-01 0.871 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.346090e-01 0.871 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.346090e-01 0.871 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.346090e-01 0.871 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.346090e-01 0.871 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.346090e-01 0.871 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.346090e-01 0.871 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.346090e-01 0.871 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.147845e-01 0.940 0 0
Regulation of TP53 Expression R-HSA-6804754 1.147845e-01 0.940 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.147845e-01 0.940 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.147845e-01 0.940 0 0
Diseases of cellular response to stress R-HSA-9675132 1.147845e-01 0.940 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.147845e-01 0.940 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.147845e-01 0.940 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.147845e-01 0.940 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.147845e-01 0.940 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.147845e-01 0.940 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.147845e-01 0.940 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.147845e-01 0.940 0 0
Potassium transport channels R-HSA-1296067 1.147845e-01 0.940 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.147845e-01 0.940 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.147845e-01 0.940 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.147845e-01 0.940 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.111865e-01 0.954 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.111865e-01 0.954 0 0
Signaling by MAPK mutants R-HSA-9652817 1.111865e-01 0.954 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.217205e-01 0.915 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.217205e-01 0.915 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.217205e-01 0.915 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.217205e-01 0.915 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.031340e-01 0.987 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.030603e-01 0.987 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.200153e-01 0.921 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.200153e-01 0.921 0 0
Notch-HLH transcription pathway R-HSA-350054 1.155476e-01 0.937 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.155476e-01 0.937 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.107204e-01 0.956 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.014153e-01 0.994 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.030633e-01 0.987 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.102851e-01 0.957 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.033901e-01 0.986 0 0
Adipogenesis R-HSA-9843745 1.280291e-01 0.893 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.314955e-01 0.881 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.200153e-01 0.921 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.342461e-01 0.872 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.217205e-01 0.915 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.103360e-01 0.957 0 0
Frs2-mediated activation R-HSA-170968 1.031340e-01 0.987 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.040042e-01 0.983 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.111865e-01 0.954 0 0
RNA Polymerase I Transcription R-HSA-73864 1.258966e-01 0.900 0 0
mTORC1-mediated signalling R-HSA-166208 1.155476e-01 0.937 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.099642e-01 0.959 1 0
MTOR signalling R-HSA-165159 1.151925e-01 0.939 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.251998e-01 0.902 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.251998e-01 0.902 0 0
GPER1 signaling R-HSA-9634597 1.185915e-01 0.926 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.087130e-01 0.964 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.102851e-01 0.957 0 0
Transmission across Chemical Synapses R-HSA-112315 1.291418e-01 0.889 0 0
Membrane Trafficking R-HSA-199991 1.118476e-01 0.951 0 0
Apoptotic factor-mediated response R-HSA-111471 1.200153e-01 0.921 0 0
Autophagy R-HSA-9612973 1.046470e-01 0.980 0 0
Polo-like kinase mediated events R-HSA-156711 1.200153e-01 0.921 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 1.155476e-01 0.937 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.127537e-01 0.948 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.217205e-01 0.915 0 0
Intraflagellar transport R-HSA-5620924 1.185915e-01 0.926 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.322795e-01 0.879 0 0
Platelet sensitization by LDL R-HSA-432142 1.200153e-01 0.921 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.054946e-01 0.977 0 0
Signal regulatory protein family interactions R-HSA-391160 1.227839e-01 0.911 0 0
Signaling by Leptin R-HSA-2586552 1.217205e-01 0.915 0 0
Growth hormone receptor signaling R-HSA-982772 1.314955e-01 0.881 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.211512e-01 0.917 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.355677e-01 0.868 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.382543e-01 0.859 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.382543e-01 0.859 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.388121e-01 0.858 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.388121e-01 0.858 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.391001e-01 0.857 0 0
DARPP-32 events R-HSA-180024 1.394795e-01 0.855 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.394795e-01 0.855 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.429285e-01 0.845 0 0
CREB phosphorylation R-HSA-199920 1.431014e-01 0.844 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.439561e-01 0.842 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.439561e-01 0.842 0 0
DCC mediated attractive signaling R-HSA-418885 1.440244e-01 0.842 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.440244e-01 0.842 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.440244e-01 0.842 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.440244e-01 0.842 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.452108e-01 0.838 0 0
Glucose metabolism R-HSA-70326 1.466574e-01 0.834 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.471502e-01 0.832 0 0
Signaling by APC mutants R-HSA-4839744 1.471502e-01 0.832 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.471502e-01 0.832 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.471502e-01 0.832 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.471502e-01 0.832 0 0
Deadenylation of mRNA R-HSA-429947 1.484720e-01 0.828 0 0
Neurodegenerative Diseases R-HSA-8863678 1.484720e-01 0.828 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.484720e-01 0.828 0 0
Regulation of gap junction activity R-HSA-191650 2.156099e-01 0.666 0 0
NADE modulates death signalling R-HSA-205025 2.156099e-01 0.666 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.156099e-01 0.666 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.156099e-01 0.666 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.156099e-01 0.666 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.156099e-01 0.666 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.156099e-01 0.666 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.156099e-01 0.666 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.776073e-01 0.751 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.776073e-01 0.751 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.776073e-01 0.751 0 0
Netrin mediated repulsion signals R-HSA-418886 1.776073e-01 0.751 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.776073e-01 0.751 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.776073e-01 0.751 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.776073e-01 0.751 0 0
Type I hemidesmosome assembly R-HSA-446107 2.140921e-01 0.669 0 0
Regulation by c-FLIP R-HSA-3371378 2.140921e-01 0.669 0 0
Dimerization of procaspase-8 R-HSA-69416 2.140921e-01 0.669 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.140921e-01 0.669 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.140921e-01 0.669 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.140921e-01 0.669 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.744219e-01 0.758 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.744219e-01 0.758 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.667171e-01 0.778 0 0
Phosphorylation of the APC/C R-HSA-176412 1.667171e-01 0.778 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.667171e-01 0.778 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.032537e-01 0.692 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.032537e-01 0.692 0 0
Regulation of IFNG signaling R-HSA-877312 2.032537e-01 0.692 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.032537e-01 0.692 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.576974e-01 0.802 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.907073e-01 0.720 0 0
Downstream signal transduction R-HSA-186763 1.720518e-01 0.764 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.222756e-01 0.653 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.253828e-01 0.647 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.076774e-01 0.683 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.650579e-01 0.782 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.910921e-01 0.719 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.019062e-01 0.695 0 0
Centrosome maturation R-HSA-380287 2.274396e-01 0.643 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.062969e-01 0.686 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.034935e-01 0.691 0 0
EGFR downregulation R-HSA-182971 1.720518e-01 0.764 0 0
IGF1R signaling cascade R-HSA-2428924 1.666712e-01 0.778 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.222756e-01 0.653 0 0
Formation of definitive endoderm R-HSA-9823730 1.576974e-01 0.802 0 0
Signaling by SCF-KIT R-HSA-1433557 2.089639e-01 0.680 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.862399e-01 0.730 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.186021e-01 0.660 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.032537e-01 0.692 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.907073e-01 0.720 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 1.778093e-01 0.750 0 0
TGFBR3 expression R-HSA-9839394 1.664192e-01 0.779 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.687155e-01 0.773 0 0
Signaling by ERBB2 R-HSA-1227986 1.922560e-01 0.716 1 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.217908e-01 0.654 0 0
G0 and Early G1 R-HSA-1538133 1.895102e-01 0.722 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.786758e-01 0.748 0 0
G1 Phase R-HSA-69236 2.253351e-01 0.647 0 0
Cyclin D associated events in G1 R-HSA-69231 2.253351e-01 0.647 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.895102e-01 0.722 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.156099e-01 0.666 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.158284e-01 0.666 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.222756e-01 0.653 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.264931e-01 0.645 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 1.667171e-01 0.778 0 0
Killing mechanisms R-HSA-9664420 1.667171e-01 0.778 0 0
Adrenoceptors R-HSA-390696 2.140921e-01 0.669 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.667171e-01 0.778 0 0
Prolonged ERK activation events R-HSA-169893 1.667171e-01 0.778 0 0
Neurexins and neuroligins R-HSA-6794361 1.661800e-01 0.779 0 0
Signalling to ERKs R-HSA-187687 1.600100e-01 0.796 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.032537e-01 0.692 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.151188e-01 0.667 0 0
PLC beta mediated events R-HSA-112043 2.056963e-01 0.687 1 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.637692e-01 0.786 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.156099e-01 0.666 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.975017e-01 0.704 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.630936e-01 0.788 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.630936e-01 0.788 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.076774e-01 0.683 0 0
Cilium Assembly R-HSA-5617833 2.128700e-01 0.672 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.895542e-01 0.722 0 0
Ca-dependent events R-HSA-111996 1.931093e-01 0.714 1 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.895542e-01 0.722 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.896615e-01 0.722 0 0
NGF-stimulated transcription R-HSA-9031628 1.934071e-01 0.714 0 0
Calmodulin induced events R-HSA-111933 1.756385e-01 0.755 1 1
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.762486e-01 0.754 0 0
Signaling by LTK R-HSA-9842663 2.032537e-01 0.692 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.760248e-01 0.754 0 0
CaM pathway R-HSA-111997 1.756385e-01 0.755 1 0
Pyroptosis R-HSA-5620971 2.253828e-01 0.647 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.760248e-01 0.754 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.076774e-01 0.683 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.744219e-01 0.758 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.630987e-01 0.788 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.878917e-01 0.726 0 0
MTF1 activates gene expression R-HSA-5660489 2.156099e-01 0.666 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.156099e-01 0.666 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.776073e-01 0.751 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.140921e-01 0.669 0 0
Signaling by AXIN mutants R-HSA-4839735 1.744219e-01 0.758 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.744219e-01 0.758 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.998153e-01 0.699 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.517049e-01 0.819 0 0
Regulated Necrosis R-HSA-5218859 2.170910e-01 0.663 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.662950e-01 0.779 0 0
Base Excision Repair R-HSA-73884 1.951653e-01 0.710 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.704950e-01 0.768 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.704950e-01 0.768 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.704950e-01 0.768 0 0
PI Metabolism R-HSA-1483255 2.112876e-01 0.675 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.931093e-01 0.714 0 0
Heme signaling R-HSA-9707616 2.195395e-01 0.658 0 0
tRNA processing in the nucleus R-HSA-6784531 2.195395e-01 0.658 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.744219e-01 0.758 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.049516e-01 0.688 0 0
UCH proteinases R-HSA-5689603 1.656212e-01 0.781 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.782521e-01 0.749 0 0
Amyloid fiber formation R-HSA-977225 2.242072e-01 0.649 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.170910e-01 0.663 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.650579e-01 0.782 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.961340e-01 0.707 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.277086e-01 0.643 0 0
HCMV Infection R-HSA-9609646 2.315922e-01 0.635 0 0
Formation of axial mesoderm R-HSA-9796292 2.333559e-01 0.632 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.333559e-01 0.632 0 0
Interleukin-6 signaling R-HSA-1059683 2.333559e-01 0.632 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.333559e-01 0.632 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.333559e-01 0.632 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.333559e-01 0.632 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.333559e-01 0.632 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.337621e-01 0.631 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.337621e-01 0.631 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.511051e-01 0.600 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.511051e-01 0.600 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.511051e-01 0.600 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.511051e-01 0.600 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.511051e-01 0.600 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.511051e-01 0.600 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.511051e-01 0.600 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.511051e-01 0.600 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.519247e-01 0.454 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.519247e-01 0.454 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.519247e-01 0.454 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.519247e-01 0.454 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.519247e-01 0.454 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.519247e-01 0.454 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.519247e-01 0.454 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.519247e-01 0.454 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.519247e-01 0.454 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.519247e-01 0.454 0 0
Defective CD320 causes MMATC R-HSA-3359485 3.519247e-01 0.454 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.519247e-01 0.454 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.519247e-01 0.454 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.519247e-01 0.454 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.519247e-01 0.454 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.519247e-01 0.454 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.519247e-01 0.454 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.519247e-01 0.454 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.519247e-01 0.454 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.519247e-01 0.454 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.519247e-01 0.454 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.519247e-01 0.454 0 0
Intestinal infectious diseases R-HSA-8942233 3.519247e-01 0.454 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.519247e-01 0.454 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.686511e-01 0.571 0 0
IRS activation R-HSA-74713 2.686511e-01 0.571 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.686511e-01 0.571 0 0
G2 Phase R-HSA-68911 2.686511e-01 0.571 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.519724e-01 0.599 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.519724e-01 0.599 0 0
WNT mediated activation of DVL R-HSA-201688 2.519724e-01 0.599 0 0
CASP8 activity is inhibited R-HSA-5218900 2.519724e-01 0.599 0 0
ALK mutants bind TKIs R-HSA-9700645 2.519724e-01 0.599 0 0
TRAIL signaling R-HSA-75158 3.216308e-01 0.493 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.216308e-01 0.493 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.216308e-01 0.493 0 0
Phosphorylation of Emi1 R-HSA-176417 3.216308e-01 0.493 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.216308e-01 0.493 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.216308e-01 0.493 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.391766e-01 0.357 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.391766e-01 0.357 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.391766e-01 0.357 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.391766e-01 0.357 0 0
Regulation of KIT signaling R-HSA-1433559 2.644391e-01 0.578 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.644391e-01 0.578 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.736049e-01 0.428 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.736049e-01 0.428 0 0
STAT5 Activation R-HSA-9645135 3.736049e-01 0.428 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.736049e-01 0.428 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.736049e-01 0.428 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.736049e-01 0.428 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.298142e-01 0.482 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.298142e-01 0.482 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.298142e-01 0.482 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.962217e-01 0.528 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.962217e-01 0.528 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.962217e-01 0.528 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.962217e-01 0.528 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.687655e-01 0.571 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.455161e-01 0.610 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.464792e-01 0.608 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.694159e-01 0.570 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.688601e-01 0.433 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.688601e-01 0.433 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.688601e-01 0.433 0 0
ERKs are inactivated R-HSA-202670 3.688601e-01 0.433 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.688601e-01 0.433 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.238842e-01 0.373 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.238842e-01 0.373 0 0
SOS-mediated signalling R-HSA-112412 4.238842e-01 0.373 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.238842e-01 0.373 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.681529e-01 0.572 1 1
Tight junction interactions R-HSA-420029 2.938528e-01 0.532 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.241208e-01 0.489 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.608284e-01 0.443 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.608284e-01 0.443 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.074758e-01 0.390 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.522767e-01 0.453 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.522767e-01 0.453 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.522767e-01 0.453 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.128702e-01 0.505 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.558666e-01 0.592 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.771320e-01 0.557 0 0
Voltage gated Potassium channels R-HSA-1296072 3.069157e-01 0.513 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.931698e-01 0.405 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.719832e-01 0.326 0 0
RSK activation R-HSA-444257 4.719832e-01 0.326 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.719832e-01 0.326 0 0
Activation of RAS in B cells R-HSA-1169092 4.719832e-01 0.326 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.724857e-01 0.565 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.009833e-01 0.521 0 0
Telomere Extension By Telomerase R-HSA-171319 3.691751e-01 0.433 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.691751e-01 0.433 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.453483e-01 0.351 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.252502e-01 0.371 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.252502e-01 0.371 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.945647e-01 0.404 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.945647e-01 0.404 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.820135e-01 0.418 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.820135e-01 0.418 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.367798e-01 0.360 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.367798e-01 0.360 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.367798e-01 0.360 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.568832e-01 0.340 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.284710e-01 0.368 0 0
Trafficking of AMPA receptors R-HSA-399719 4.451189e-01 0.352 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.500769e-01 0.347 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.503797e-01 0.346 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.556596e-01 0.341 0 0
RNA Polymerase III Transcription R-HSA-74158 4.284710e-01 0.368 0 0
Interferon alpha/beta signaling R-HSA-909733 4.073548e-01 0.390 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.945647e-01 0.404 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.199127e-01 0.377 0 0
Signaling by NOTCH2 R-HSA-1980145 3.820135e-01 0.418 0 0
Specification of the neural plate border R-HSA-9834899 2.687655e-01 0.571 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.357318e-01 0.474 0 0
Signaling by FGFR3 R-HSA-5654741 3.603337e-01 0.443 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.706910e-01 0.431 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.706910e-01 0.431 0 0
Signaling by FGFR4 R-HSA-5654743 3.205419e-01 0.494 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.453483e-01 0.351 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.138612e-01 0.383 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.515655e-01 0.345 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.043698e-01 0.517 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.688601e-01 0.433 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.616345e-01 0.442 0 0
IRS-mediated signalling R-HSA-112399 4.648554e-01 0.333 0 0
Insulin receptor signalling cascade R-HSA-74751 4.681034e-01 0.330 0 0
Activation of GABAB receptors R-HSA-991365 4.353394e-01 0.361 0 0
Signaling by FGFR1 R-HSA-5654736 4.458790e-01 0.351 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.596925e-01 0.586 1 1
Assembly of the pre-replicative complex R-HSA-68867 2.413774e-01 0.617 0 0
Signal attenuation R-HSA-74749 2.907087e-01 0.537 0 0
Integration of provirus R-HSA-162592 3.688601e-01 0.433 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.568832e-01 0.340 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.283266e-01 0.484 0 0
Transcription of the HIV genome R-HSA-167172 4.192097e-01 0.378 0 0
Interleukin-2 family signaling R-HSA-451927 2.443463e-01 0.612 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.694159e-01 0.570 0 0
PI3K Cascade R-HSA-109704 3.320054e-01 0.479 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.187046e-01 0.497 0 0
Interleukin-15 signaling R-HSA-8983432 4.074758e-01 0.390 0 0
GAB1 signalosome R-HSA-180292 2.419068e-01 0.616 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.451189e-01 0.352 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.216308e-01 0.493 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.238842e-01 0.373 0 0
Nuclear RNA decay R-HSA-9930044 3.357318e-01 0.474 0 0
Peptide chain elongation R-HSA-156902 3.326464e-01 0.478 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.776776e-01 0.423 0 0
Myogenesis R-HSA-525793 3.187046e-01 0.497 0 0
Mitophagy R-HSA-5205647 2.458930e-01 0.609 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.357318e-01 0.474 0 0
GABA B receptor activation R-HSA-977444 4.353394e-01 0.361 0 0
Interleukin-9 signaling R-HSA-8985947 4.719832e-01 0.326 0 0
TNF signaling R-HSA-75893 3.241488e-01 0.489 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.686511e-01 0.571 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.419068e-01 0.616 0 0
Passive transport by Aquaporins R-HSA-432047 3.608284e-01 0.443 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.608284e-01 0.443 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.074758e-01 0.390 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.813273e-01 0.419 0 0
Hedgehog 'off' state R-HSA-5610787 4.387360e-01 0.358 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.817264e-01 0.550 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.805364e-01 0.420 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.743756e-01 0.562 0 0
Signaling by WNT R-HSA-195721 4.592946e-01 0.338 0 0
HIV Life Cycle R-HSA-162587 2.549046e-01 0.594 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.963500e-01 0.402 0 0
S Phase R-HSA-69242 4.458765e-01 0.351 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.284353e-01 0.484 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.006452e-01 0.397 0 0
Potassium Channels R-HSA-1296071 3.813273e-01 0.419 0 0
Signaling by WNT in cancer R-HSA-4791275 3.128702e-01 0.505 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.109682e-01 0.507 0 0
DNA Damage Bypass R-HSA-73893 3.134507e-01 0.504 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.216308e-01 0.493 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.907087e-01 0.537 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.458930e-01 0.609 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.938528e-01 0.532 1 1
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.438510e-01 0.464 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.719832e-01 0.326 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.719832e-01 0.326 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.719832e-01 0.326 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.453483e-01 0.351 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.588088e-01 0.445 1 1
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.603337e-01 0.443 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.113388e-01 0.507 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.756619e-01 0.425 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.046310e-01 0.516 0 0
Ion homeostasis R-HSA-5578775 4.458790e-01 0.351 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.608284e-01 0.443 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.199127e-01 0.377 0 0
GPVI-mediated activation cascade R-HSA-114604 4.284710e-01 0.368 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.956201e-01 0.403 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.962217e-01 0.528 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.284353e-01 0.484 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.608284e-01 0.443 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.568832e-01 0.340 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.519724e-01 0.599 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.284353e-01 0.484 0 0
Acyl chain remodelling of PS R-HSA-1482801 2.938528e-01 0.532 0 0
Platelet calcium homeostasis R-HSA-418360 3.945647e-01 0.404 0 0
Signaling by TGFB family members R-HSA-9006936 2.840007e-01 0.547 0 0
DAG and IP3 signaling R-HSA-1489509 2.421824e-01 0.616 1 1
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.207084e-01 0.376 0 0
Cardiac conduction R-HSA-5576891 3.025901e-01 0.519 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.012845e-01 0.521 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.519724e-01 0.599 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.907087e-01 0.537 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.962217e-01 0.528 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.688601e-01 0.433 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.719832e-01 0.326 0 0
Eukaryotic Translation Termination R-HSA-72764 4.652062e-01 0.332 0 0
Cardiogenesis R-HSA-9733709 3.357318e-01 0.474 0 0
Adaptive Immune System R-HSA-1280218 4.539823e-01 0.343 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.903135e-01 0.537 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.686511e-01 0.571 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.464792e-01 0.608 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.522767e-01 0.453 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.920462e-01 0.535 0 0
Rab regulation of trafficking R-HSA-9007101 4.337729e-01 0.363 0 0
Signaling by PTK6 R-HSA-8848021 3.334712e-01 0.477 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.334712e-01 0.477 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.511051e-01 0.600 0 0
Inhibition of PKR R-HSA-169131 2.511051e-01 0.600 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.519247e-01 0.454 0 0
ARMS-mediated activation R-HSA-170984 2.519724e-01 0.599 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.519724e-01 0.599 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.391766e-01 0.357 0 0
C6 deamination of adenosine R-HSA-75102 4.391766e-01 0.357 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.391766e-01 0.357 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.736049e-01 0.428 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.419068e-01 0.616 0 0
Negative regulation of FLT3 R-HSA-9706369 3.284353e-01 0.484 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.284353e-01 0.484 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.238842e-01 0.373 0 0
Disorders of Developmental Biology R-HSA-9675151 3.608284e-01 0.443 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.069157e-01 0.513 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.334712e-01 0.477 0 0
Smooth Muscle Contraction R-HSA-445355 3.886776e-01 0.410 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.389605e-01 0.470 0 0
Signaling by NOTCH4 R-HSA-9013694 4.073776e-01 0.390 0 0
Interleukin-1 family signaling R-HSA-446652 2.695105e-01 0.569 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.187046e-01 0.497 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.357318e-01 0.474 0 0
MAP kinase activation R-HSA-450294 3.001662e-01 0.523 0 0
Host Interactions of HIV factors R-HSA-162909 3.517430e-01 0.454 0 0
Interleukin-7 signaling R-HSA-1266695 4.644981e-01 0.333 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.694159e-01 0.570 0 0
The NLRP3 inflammasome R-HSA-844456 4.568832e-01 0.340 0 0
Stimuli-sensing channels R-HSA-2672351 4.696003e-01 0.328 0 0
PECAM1 interactions R-HSA-210990 3.298142e-01 0.482 0 0
Long-term potentiation R-HSA-9620244 2.938528e-01 0.532 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.719832e-01 0.326 0 0
Interleukin-17 signaling R-HSA-448424 4.537723e-01 0.343 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.043698e-01 0.517 0 0
Formation of the nephric duct R-HSA-9830364 2.938528e-01 0.532 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.357318e-01 0.474 0 0
Hemostasis R-HSA-109582 3.430997e-01 0.465 1 0
Pervasive developmental disorders R-HSA-9005895 4.074758e-01 0.390 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.074758e-01 0.390 0 0
Disorders of Nervous System Development R-HSA-9697154 4.074758e-01 0.390 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.931698e-01 0.405 0 0
RAB geranylgeranylation R-HSA-8873719 3.957462e-01 0.403 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.570669e-01 0.340 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.421824e-01 0.616 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.101129e-01 0.508 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.550833e-01 0.450 0 0
Inositol phosphate metabolism R-HSA-1483249 2.628105e-01 0.580 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.997933e-01 0.523 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.132847e-01 0.384 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.686511e-01 0.571 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.216308e-01 0.493 0 0
DSCAM interactions R-HSA-376172 4.391766e-01 0.357 0 0
Synthesis of PI R-HSA-1483226 3.298142e-01 0.482 0 0
Alpha-defensins R-HSA-1462054 4.719832e-01 0.326 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.077468e-01 0.390 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.138612e-01 0.383 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.241208e-01 0.489 0 0
OAS antiviral response R-HSA-8983711 4.074758e-01 0.390 0 0
Co-inhibition by BTLA R-HSA-9927353 2.686511e-01 0.571 0 0
NrCAM interactions R-HSA-447038 2.686511e-01 0.571 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.391766e-01 0.357 0 0
Sodium/Proton exchangers R-HSA-425986 4.719832e-01 0.326 0 0
IRE1alpha activates chaperones R-HSA-381070 3.910346e-01 0.408 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.246989e-01 0.489 0 0
Maturation of nucleoprotein R-HSA-9683610 4.453483e-01 0.351 0 0
Specification of primordial germ cells R-HSA-9827857 3.931698e-01 0.405 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.216308e-01 0.493 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.216308e-01 0.493 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.391766e-01 0.357 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.252502e-01 0.371 0 0
Influenza Infection R-HSA-168255 3.522194e-01 0.453 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.744726e-01 0.324 0 0
Toll-like Receptor Cascades R-HSA-168898 4.779169e-01 0.321 0 0
Amine ligand-binding receptors R-HSA-375280 4.780613e-01 0.321 0 0
Removal of the Flap Intermediate R-HSA-69166 4.822191e-01 0.317 0 0
cGMP effects R-HSA-418457 4.822191e-01 0.317 0 0
Prolactin receptor signaling R-HSA-1170546 4.822191e-01 0.317 0 0
SARS-CoV Infections R-HSA-9679506 4.829598e-01 0.316 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.879056e-01 0.312 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.879056e-01 0.312 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.879056e-01 0.312 0 0
Signal transduction by L1 R-HSA-445144 4.879056e-01 0.312 0 0
Protein hydroxylation R-HSA-9629569 4.879056e-01 0.312 0 0
Nephrin family interactions R-HSA-373753 4.879056e-01 0.312 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.880952e-01 0.311 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.947400e-01 0.306 0 0
Co-inhibition by PD-1 R-HSA-389948 4.998522e-01 0.301 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.008789e-01 0.300 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.008789e-01 0.300 0 0
Extension of Telomeres R-HSA-180786 5.024253e-01 0.299 0 0
Signaling by FGFR2 R-HSA-5654738 5.062645e-01 0.296 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.073558e-01 0.295 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.146859e-01 0.288 0 0
Activation of Na-permeable kainate receptors R-HSA-451307 5.146859e-01 0.288 0 0
Axonal growth stimulation R-HSA-209563 5.146859e-01 0.288 0 0
Invadopodia formation R-HSA-8941237 5.146859e-01 0.288 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.146859e-01 0.288 0 0
Classical Kir channels R-HSA-1296053 5.146859e-01 0.288 0 0
MET activates PTPN11 R-HSA-8865999 5.146859e-01 0.288 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.146859e-01 0.288 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.146859e-01 0.288 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 5.146859e-01 0.288 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.146859e-01 0.288 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.146859e-01 0.288 0 0
Histamine receptors R-HSA-390650 5.146859e-01 0.288 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.146859e-01 0.288 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.146859e-01 0.288 0 0
FasL/ CD95L signaling R-HSA-75157 5.146859e-01 0.288 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.175779e-01 0.286 1 1
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 5.175779e-01 0.286 0 0
Interleukin-21 signaling R-HSA-9020958 5.175779e-01 0.286 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.175779e-01 0.286 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.175779e-01 0.286 0 0
Calcineurin activates NFAT R-HSA-2025928 5.175779e-01 0.286 0 0
mRNA Editing R-HSA-75072 5.175779e-01 0.286 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.175779e-01 0.286 0 0
Interleukin-1 processing R-HSA-448706 5.175779e-01 0.286 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.175779e-01 0.286 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.175779e-01 0.286 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.178803e-01 0.286 0 0
p75NTR signals via NF-kB R-HSA-193639 5.178803e-01 0.286 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.178803e-01 0.286 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.178803e-01 0.286 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.178803e-01 0.286 0 0
p38MAPK events R-HSA-171007 5.178803e-01 0.286 0 0
Formation of the anterior neural plate R-HSA-9823739 5.178803e-01 0.286 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 5.181770e-01 0.286 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.181770e-01 0.286 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.181770e-01 0.286 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.181770e-01 0.286 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.181770e-01 0.286 0 0
Signalling to RAS R-HSA-167044 5.181770e-01 0.286 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.181770e-01 0.286 0 0
ERK/MAPK targets R-HSA-198753 5.181770e-01 0.286 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.185556e-01 0.285 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.185556e-01 0.285 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.185556e-01 0.285 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.189909e-01 0.285 0 0
Generation of second messenger molecules R-HSA-202433 5.194597e-01 0.284 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.194597e-01 0.284 0 0
Diseases of Immune System R-HSA-5260271 5.194597e-01 0.284 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.199471e-01 0.284 0 0
GABA receptor activation R-HSA-977443 5.209434e-01 0.283 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.284220e-01 0.277 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.386128e-01 0.269 0 0
Protein ubiquitination R-HSA-8852135 5.386128e-01 0.269 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.404513e-01 0.267 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.414208e-01 0.266 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.427726e-01 0.265 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.447037e-01 0.264 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.447037e-01 0.264 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.447037e-01 0.264 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.475794e-01 0.262 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.475794e-01 0.262 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.475794e-01 0.262 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.475794e-01 0.262 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.475794e-01 0.262 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.521698e-01 0.258 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 5.521698e-01 0.258 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.521698e-01 0.258 0 0
Activation of SMO R-HSA-5635838 5.521698e-01 0.258 0 0
Selenocysteine synthesis R-HSA-2408557 5.525689e-01 0.258 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.542735e-01 0.256 0 0
G alpha (z) signalling events R-HSA-418597 5.587547e-01 0.253 1 1
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.604706e-01 0.251 0 0
2-LTR circle formation R-HSA-164843 5.604706e-01 0.251 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.604706e-01 0.251 0 0
PI3K/AKT activation R-HSA-198203 5.604706e-01 0.251 0 0
Interleukin-27 signaling R-HSA-9020956 5.604706e-01 0.251 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.604706e-01 0.251 0 0
Pexophagy R-HSA-9664873 5.604706e-01 0.251 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.604706e-01 0.251 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.604706e-01 0.251 0 0
Formation of apoptosome R-HSA-111458 5.604706e-01 0.251 0 0
Cellular response to chemical stress R-HSA-9711123 5.608483e-01 0.251 1 0
Signaling by Hedgehog R-HSA-5358351 5.631555e-01 0.249 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.660229e-01 0.247 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.660229e-01 0.247 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.660229e-01 0.247 0 0
PERK regulates gene expression R-HSA-381042 5.660229e-01 0.247 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.701580e-01 0.244 0 0
HIV Infection R-HSA-162906 5.704320e-01 0.244 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.730234e-01 0.242 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.750246e-01 0.240 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.751374e-01 0.240 0 0
Signaling by KIT in disease R-HSA-9669938 5.760155e-01 0.240 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.760155e-01 0.240 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.760155e-01 0.240 0 0
FGFR2 alternative splicing R-HSA-6803529 5.760155e-01 0.240 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.760155e-01 0.240 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.760155e-01 0.240 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.760155e-01 0.240 0 0
Cellular response to heat stress R-HSA-3371556 5.774410e-01 0.238 0 0
HCN channels R-HSA-1296061 5.800324e-01 0.237 0 0
Nucleotide catabolism defects R-HSA-9735786 5.800324e-01 0.237 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.800324e-01 0.237 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.800324e-01 0.237 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.800324e-01 0.237 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.800324e-01 0.237 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.800324e-01 0.237 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.800324e-01 0.237 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.800324e-01 0.237 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.800324e-01 0.237 0 0
Transmission across Electrical Synapses R-HSA-112307 5.800324e-01 0.237 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.800324e-01 0.237 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.800324e-01 0.237 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.803667e-01 0.236 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.803667e-01 0.236 0 0
Viral mRNA Translation R-HSA-192823 5.806592e-01 0.236 0 0
Phase 2 - plateau phase R-HSA-5576893 5.849667e-01 0.233 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.849667e-01 0.233 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.849667e-01 0.233 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.849667e-01 0.233 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.849667e-01 0.233 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.849667e-01 0.233 0 0
DNA Replication R-HSA-69306 5.853409e-01 0.233 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.861329e-01 0.232 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.948535e-01 0.226 0 0
Activation of the pre-replicative complex R-HSA-68962 5.948535e-01 0.226 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.948535e-01 0.226 0 0
DAP12 signaling R-HSA-2424491 5.948535e-01 0.226 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.948535e-01 0.226 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.948535e-01 0.226 0 0
Regulation of CDH1 Function R-HSA-9764561 5.957438e-01 0.225 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.004914e-01 0.221 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.005625e-01 0.221 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.005625e-01 0.221 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.005625e-01 0.221 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.005625e-01 0.221 0 0
Formation of the posterior neural plate R-HSA-9832991 6.005625e-01 0.221 0 0
Transport of RCbl within the body R-HSA-9758890 6.005625e-01 0.221 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 6.005625e-01 0.221 0 0
Suppression of apoptosis R-HSA-9635465 6.005625e-01 0.221 0 0
Prostanoid ligand receptors R-HSA-391908 6.005625e-01 0.221 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 6.034078e-01 0.219 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.107203e-01 0.214 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.161867e-01 0.210 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.161867e-01 0.210 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.161867e-01 0.210 0 0
Integration of energy metabolism R-HSA-163685 6.234821e-01 0.205 0 0
HCMV Late Events R-HSA-9610379 6.296510e-01 0.201 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.296972e-01 0.201 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.296972e-01 0.201 0 0
Interleukin-6 family signaling R-HSA-6783589 6.296972e-01 0.201 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.296972e-01 0.201 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.296972e-01 0.201 0 0
Regulation of beta-cell development R-HSA-186712 6.311771e-01 0.200 0 0
Platelet homeostasis R-HSA-418346 6.345726e-01 0.198 0 0
Activation of AMPA receptors R-HSA-399710 6.365834e-01 0.196 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.365834e-01 0.196 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.365834e-01 0.196 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.365834e-01 0.196 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.365834e-01 0.196 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.365834e-01 0.196 0 0
Activation of AKT2 R-HSA-165158 6.365834e-01 0.196 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.365834e-01 0.196 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.365834e-01 0.196 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.365834e-01 0.196 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.365834e-01 0.196 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.365834e-01 0.196 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.365834e-01 0.196 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.365834e-01 0.196 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.365834e-01 0.196 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.365834e-01 0.196 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.378301e-01 0.195 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.378301e-01 0.195 0 0
NF-kB is activated and signals survival R-HSA-209560 6.378301e-01 0.195 0 0
Sodium/Calcium exchangers R-HSA-425561 6.378301e-01 0.195 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.378301e-01 0.195 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.378301e-01 0.195 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.457767e-01 0.190 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.457767e-01 0.190 0 0
PKA activation in glucagon signalling R-HSA-164378 6.457767e-01 0.190 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.457767e-01 0.190 0 0
Mismatch Repair R-HSA-5358508 6.457767e-01 0.190 0 0
PKA activation R-HSA-163615 6.457767e-01 0.190 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.457767e-01 0.190 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.457767e-01 0.190 0 0
Tie2 Signaling R-HSA-210993 6.457767e-01 0.190 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.457767e-01 0.190 0 0
Immune System R-HSA-168256 6.530536e-01 0.185 1 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.548408e-01 0.184 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.548408e-01 0.184 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.548408e-01 0.184 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.548707e-01 0.184 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.628451e-01 0.179 0 0
G-protein beta:gamma signalling R-HSA-397795 6.639050e-01 0.178 0 0
Neutrophil degranulation R-HSA-6798695 6.644259e-01 0.178 1 1
p75NTR recruits signalling complexes R-HSA-209543 6.723070e-01 0.172 0 0
Polymerase switching R-HSA-69091 6.723070e-01 0.172 0 0
Leading Strand Synthesis R-HSA-69109 6.723070e-01 0.172 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.723070e-01 0.172 0 0
Interleukin-35 Signalling R-HSA-8984722 6.723070e-01 0.172 0 0
Repression of WNT target genes R-HSA-4641265 6.723070e-01 0.172 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.723070e-01 0.172 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.723070e-01 0.172 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.723070e-01 0.172 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.726696e-01 0.172 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.737108e-01 0.172 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.737108e-01 0.172 0 0
Other interleukin signaling R-HSA-449836 6.737108e-01 0.172 0 0
Maturation of nucleoprotein R-HSA-9694631 6.737108e-01 0.172 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.788110e-01 0.168 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.788110e-01 0.168 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.788110e-01 0.168 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.788110e-01 0.168 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.788110e-01 0.168 0 0
Signaling by PDGF R-HSA-186797 6.810202e-01 0.167 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.851341e-01 0.164 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.851341e-01 0.164 0 0
Plus-strand DNA synthesis R-HSA-164525 6.855223e-01 0.164 0 0
PKB-mediated events R-HSA-109703 6.855223e-01 0.164 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.855223e-01 0.164 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.855223e-01 0.164 0 0
PDE3B signalling R-HSA-165160 6.855223e-01 0.164 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.855223e-01 0.164 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.855223e-01 0.164 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.855223e-01 0.164 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.855223e-01 0.164 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.855223e-01 0.164 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.855223e-01 0.164 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.855223e-01 0.164 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.855223e-01 0.164 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.855223e-01 0.164 0 0
Synthesis of PS R-HSA-1483101 6.855223e-01 0.164 0 0
Formation of the Editosome R-HSA-75094 6.855223e-01 0.164 0 0
Ceramide signalling R-HSA-193681 6.855223e-01 0.164 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.855223e-01 0.164 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.855223e-01 0.164 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.855223e-01 0.164 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.855223e-01 0.164 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.855223e-01 0.164 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.855223e-01 0.164 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.890458e-01 0.162 0 0
Metal ion SLC transporters R-HSA-425410 6.986310e-01 0.156 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.999859e-01 0.155 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.015932e-01 0.154 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.015932e-01 0.154 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.015932e-01 0.154 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.015932e-01 0.154 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.015932e-01 0.154 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.040689e-01 0.152 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.040689e-01 0.152 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.040689e-01 0.152 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.040689e-01 0.152 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 7.040689e-01 0.152 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.040689e-01 0.152 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.040689e-01 0.152 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.040689e-01 0.152 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.040689e-01 0.152 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.040689e-01 0.152 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.054372e-01 0.152 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.054372e-01 0.152 0 0
Signaling by FGFR R-HSA-190236 7.061511e-01 0.151 0 0
G alpha (s) signalling events R-HSA-418555 7.082693e-01 0.150 0 0
HIV Transcription Initiation R-HSA-167161 7.102740e-01 0.149 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.102740e-01 0.149 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.102740e-01 0.149 0 0
Intra-Golgi traffic R-HSA-6811438 7.102740e-01 0.149 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.102740e-01 0.149 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.109406e-01 0.148 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.118612e-01 0.148 0 0
Cellular response to starvation R-HSA-9711097 7.140707e-01 0.146 0 0
Degradation of CDH1 R-HSA-9766229 7.155595e-01 0.145 0 0
G1/S Transition R-HSA-69206 7.218835e-01 0.142 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.231846e-01 0.141 0 0
HIV elongation arrest and recovery R-HSA-167287 7.231846e-01 0.141 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.231846e-01 0.141 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.231846e-01 0.141 0 0
Inflammasomes R-HSA-622312 7.231846e-01 0.141 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.240142e-01 0.140 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.246182e-01 0.140 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.246182e-01 0.140 0 0
Lagging Strand Synthesis R-HSA-69186 7.246182e-01 0.140 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.246182e-01 0.140 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.246182e-01 0.140 0 0
Basigin interactions R-HSA-210991 7.246182e-01 0.140 0 0
Parasitic Infection Pathways R-HSA-9824443 7.254408e-01 0.139 0 0
Leishmania infection R-HSA-9658195 7.254408e-01 0.139 0 0
Signaling by LTK in cancer R-HSA-9842640 7.278734e-01 0.138 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.278734e-01 0.138 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 7.278734e-01 0.138 0 0
Uncoating of the HIV Virion R-HSA-162585 7.278734e-01 0.138 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.278734e-01 0.138 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.278734e-01 0.138 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.278734e-01 0.138 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.278734e-01 0.138 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.278734e-01 0.138 0 0
Abacavir transmembrane transport R-HSA-2161517 7.278734e-01 0.138 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.278734e-01 0.138 0 0
NADPH regeneration R-HSA-389542 7.278734e-01 0.138 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.278734e-01 0.138 0 0
Lipid particle organization R-HSA-8964572 7.278734e-01 0.138 0 0
Leukotriene receptors R-HSA-391906 7.278734e-01 0.138 0 0
Nef and signal transduction R-HSA-164944 7.278734e-01 0.138 0 0
Neurofascin interactions R-HSA-447043 7.278734e-01 0.138 0 0
Circadian clock R-HSA-9909396 7.281791e-01 0.138 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.318345e-01 0.136 0 0
Ca2+ pathway R-HSA-4086398 7.320060e-01 0.135 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.332217e-01 0.135 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.332217e-01 0.135 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.332217e-01 0.135 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.332217e-01 0.135 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.332217e-01 0.135 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.332217e-01 0.135 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.332217e-01 0.135 0 0
HDL assembly R-HSA-8963896 7.332217e-01 0.135 0 0
Zinc transporters R-HSA-435354 7.332217e-01 0.135 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.332217e-01 0.135 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.355927e-01 0.133 1 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.373963e-01 0.132 0 0
G1/S-Specific Transcription R-HSA-69205 7.432440e-01 0.129 0 0
FLT3 signaling in disease R-HSA-9682385 7.432440e-01 0.129 0 0
RUNX2 regulates bone development R-HSA-8941326 7.432440e-01 0.129 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.435927e-01 0.129 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.435927e-01 0.129 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.448115e-01 0.128 0 0
Signaling by FGFR in disease R-HSA-1226099 7.453418e-01 0.128 0 0
Signaling by ERBB4 R-HSA-1236394 7.453418e-01 0.128 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.472779e-01 0.127 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.476390e-01 0.126 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.476390e-01 0.126 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.478474e-01 0.126 0 0
Developmental Cell Lineages R-HSA-9734767 7.527037e-01 0.123 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.582199e-01 0.120 0 0
GPCR downstream signalling R-HSA-388396 7.592777e-01 0.120 1 0
Erythropoietin activates RAS R-HSA-9027284 7.598921e-01 0.119 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.598921e-01 0.119 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.598921e-01 0.119 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.598921e-01 0.119 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.598921e-01 0.119 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.598921e-01 0.119 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.598921e-01 0.119 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.598921e-01 0.119 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.598921e-01 0.119 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.598921e-01 0.119 0 0
Protein methylation R-HSA-8876725 7.598921e-01 0.119 0 0
DAP12 interactions R-HSA-2172127 7.609261e-01 0.119 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.624141e-01 0.118 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.645231e-01 0.117 0 0
CHL1 interactions R-HSA-447041 7.645231e-01 0.117 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.645231e-01 0.117 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.645231e-01 0.117 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.645231e-01 0.117 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.645231e-01 0.117 0 0
Recycling of eIF2:GDP R-HSA-72731 7.645231e-01 0.117 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.645231e-01 0.117 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.645231e-01 0.117 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.645231e-01 0.117 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.645231e-01 0.117 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.645231e-01 0.117 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.645231e-01 0.117 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.645231e-01 0.117 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.645231e-01 0.117 0 0
Glycoprotein hormones R-HSA-209822 7.645231e-01 0.117 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.645231e-01 0.117 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.645231e-01 0.117 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.690923e-01 0.114 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.690923e-01 0.114 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.702747e-01 0.113 1 1
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.721568e-01 0.112 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.739718e-01 0.111 0 0
Potential therapeutics for SARS R-HSA-9679191 7.762079e-01 0.110 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.762780e-01 0.110 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.767221e-01 0.110 0 0
MET promotes cell motility R-HSA-8875878 7.773471e-01 0.109 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.809304e-01 0.107 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.809304e-01 0.107 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.842197e-01 0.106 0 0
Atorvastatin ADME R-HSA-9754706 7.842197e-01 0.106 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.842197e-01 0.106 0 0
Regulation of BACH1 activity R-HSA-9708530 7.842197e-01 0.106 0 0
Differentiation of T cells R-HSA-9945266 7.842197e-01 0.106 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.842197e-01 0.106 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.842197e-01 0.106 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.853303e-01 0.105 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.890319e-01 0.103 0 0
Interleukin-20 family signaling R-HSA-8854691 7.890319e-01 0.103 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.890319e-01 0.103 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.890319e-01 0.103 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.890319e-01 0.103 0 0
Syndecan interactions R-HSA-3000170 7.890319e-01 0.103 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.908764e-01 0.102 0 0
Regulation of insulin secretion R-HSA-422356 7.912882e-01 0.102 0 0
rRNA processing R-HSA-72312 7.925118e-01 0.101 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.930407e-01 0.101 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.930407e-01 0.101 0 0
Ribosome-associated quality control R-HSA-9948299 7.937155e-01 0.100 0 0
Nucleotide Excision Repair R-HSA-5696398 7.944061e-01 0.100 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.962387e-01 0.099 0 0
Minus-strand DNA synthesis R-HSA-164516 7.962387e-01 0.099 0 0
phospho-PLA2 pathway R-HSA-111995 7.962387e-01 0.099 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.962387e-01 0.099 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.962387e-01 0.099 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.962387e-01 0.099 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.962387e-01 0.099 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.962387e-01 0.099 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.962387e-01 0.099 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.962387e-01 0.099 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.962387e-01 0.099 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.979131e-01 0.098 0 0
DNA strand elongation R-HSA-69190 7.979131e-01 0.098 0 0
Viral Infection Pathways R-HSA-9824446 7.994666e-01 0.097 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.007491e-01 0.097 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.039252e-01 0.095 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.039252e-01 0.095 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.063518e-01 0.093 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.063518e-01 0.093 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.063518e-01 0.093 0 0
Synthesis of PG R-HSA-1483148 8.063518e-01 0.093 0 0
Response to metal ions R-HSA-5660526 8.063518e-01 0.093 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.075186e-01 0.093 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.075186e-01 0.093 0 0
HIV Transcription Elongation R-HSA-167169 8.078545e-01 0.093 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.078545e-01 0.093 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.078545e-01 0.093 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.078545e-01 0.093 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.078545e-01 0.093 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.150659e-01 0.089 1 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.157970e-01 0.088 0 0
PPARA activates gene expression R-HSA-1989781 8.164533e-01 0.088 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.181551e-01 0.087 0 0
Interleukin-1 signaling R-HSA-9020702 8.201778e-01 0.086 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.218118e-01 0.085 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.236842e-01 0.084 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.236842e-01 0.084 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.236842e-01 0.084 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.236842e-01 0.084 0 0
Unwinding of DNA R-HSA-176974 8.236842e-01 0.084 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.236842e-01 0.084 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.236842e-01 0.084 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.236842e-01 0.084 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.236842e-01 0.084 0 0
Lipophagy R-HSA-9613354 8.236842e-01 0.084 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.236842e-01 0.084 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.236842e-01 0.084 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.241855e-01 0.084 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.246189e-01 0.084 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.246189e-01 0.084 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.264384e-01 0.083 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.264384e-01 0.083 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.264384e-01 0.083 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.264384e-01 0.083 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.264384e-01 0.083 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.264384e-01 0.083 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.264384e-01 0.083 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.264384e-01 0.083 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.264384e-01 0.083 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.286775e-01 0.082 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.291175e-01 0.081 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.302907e-01 0.081 0 0
Vesicle-mediated transport R-HSA-5653656 8.339744e-01 0.079 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.349386e-01 0.078 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.349386e-01 0.078 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.387508e-01 0.076 0 0
TCR signaling R-HSA-202403 8.389843e-01 0.076 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.404026e-01 0.076 0 0
Dual Incision in GG-NER R-HSA-5696400 8.425389e-01 0.074 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.425389e-01 0.074 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.425389e-01 0.074 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.425389e-01 0.074 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.446289e-01 0.073 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.446289e-01 0.073 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.446289e-01 0.073 0 0
Interferon gamma signaling R-HSA-877300 8.447091e-01 0.073 1 1
RNA Polymerase I Transcription Initiation R-HSA-73762 8.472633e-01 0.072 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.472633e-01 0.072 0 0
Binding and entry of HIV virion R-HSA-173107 8.474344e-01 0.072 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.474344e-01 0.072 0 0
DNA replication initiation R-HSA-68952 8.474344e-01 0.072 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.474344e-01 0.072 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.474344e-01 0.072 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.474344e-01 0.072 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.474344e-01 0.072 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.474344e-01 0.072 0 0
Maturation of spike protein R-HSA-9683686 8.474344e-01 0.072 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.474344e-01 0.072 0 0
Peptide hormone biosynthesis R-HSA-209952 8.474344e-01 0.072 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.474344e-01 0.072 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.549415e-01 0.068 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.549415e-01 0.068 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.554438e-01 0.068 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.610694e-01 0.065 0 0
Regulation of signaling by CBL R-HSA-912631 8.610694e-01 0.065 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.610694e-01 0.065 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.635216e-01 0.064 0 0
Leishmania phagocytosis R-HSA-9664417 8.656475e-01 0.063 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.656475e-01 0.063 0 0
Parasite infection R-HSA-9664407 8.656475e-01 0.063 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.668845e-01 0.062 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.674372e-01 0.062 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.679865e-01 0.061 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.679865e-01 0.061 0 0
vRNA Synthesis R-HSA-192814 8.679865e-01 0.061 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.679865e-01 0.061 0 0
Bicarbonate transporters R-HSA-425381 8.679865e-01 0.061 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.679865e-01 0.061 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.679865e-01 0.061 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.679865e-01 0.061 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.679865e-01 0.061 0 0
Aquaporin-mediated transport R-HSA-445717 8.688354e-01 0.061 0 0
Signaling by Insulin receptor R-HSA-74752 8.694565e-01 0.061 0 0
Platelet degranulation R-HSA-114608 8.701306e-01 0.060 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.759014e-01 0.058 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.759014e-01 0.058 0 0
Signaling by NODAL R-HSA-1181150 8.759014e-01 0.058 0 0
Negative regulation of MET activity R-HSA-6807004 8.759014e-01 0.058 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.781284e-01 0.056 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.797309e-01 0.056 0 0
Signaling by Erythropoietin R-HSA-9006335 8.805756e-01 0.055 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.805756e-01 0.055 0 0
Hedgehog 'on' state R-HSA-5632684 8.825735e-01 0.054 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.857711e-01 0.053 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.857711e-01 0.053 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.857711e-01 0.053 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.857711e-01 0.053 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.857711e-01 0.053 0 0
FMO oxidises nucleophiles R-HSA-217271 8.857711e-01 0.053 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.857711e-01 0.053 0 0
Signaling by MET R-HSA-6806834 8.874947e-01 0.052 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.891581e-01 0.051 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.891581e-01 0.051 0 0
G-protein activation R-HSA-202040 8.892597e-01 0.051 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.892597e-01 0.051 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.892597e-01 0.051 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.892597e-01 0.051 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.892597e-01 0.051 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.892597e-01 0.051 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.918148e-01 0.050 0 0
Stabilization of p53 R-HSA-69541 8.984068e-01 0.047 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.992596e-01 0.046 0 0
Mitochondrial biogenesis R-HSA-1592230 9.001884e-01 0.046 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 9.011606e-01 0.045 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 9.011606e-01 0.045 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 9.011606e-01 0.045 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.011606e-01 0.045 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.011606e-01 0.045 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.011606e-01 0.045 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 9.011606e-01 0.045 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.011606e-01 0.045 0 0
MET activates RAS signaling R-HSA-8851805 9.011606e-01 0.045 0 0
Estrogen biosynthesis R-HSA-193144 9.011606e-01 0.045 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.011606e-01 0.045 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.012722e-01 0.045 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.012722e-01 0.045 0 0
Cellular response to hypoxia R-HSA-1234174 9.015987e-01 0.045 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.072123e-01 0.042 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.097101e-01 0.041 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.110264e-01 0.040 0 0
Free fatty acid receptors R-HSA-444209 9.120589e-01 0.040 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.120589e-01 0.040 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.120589e-01 0.040 0 0
Dual incision in TC-NER R-HSA-6782135 9.138993e-01 0.039 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.138993e-01 0.039 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.144776e-01 0.039 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.144776e-01 0.039 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.144776e-01 0.039 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.144776e-01 0.039 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.144776e-01 0.039 0 0
Chylomicron remodeling R-HSA-8963901 9.144776e-01 0.039 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.144776e-01 0.039 0 0
Processing of SMDT1 R-HSA-8949664 9.144776e-01 0.039 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.144776e-01 0.039 0 0
G alpha (q) signalling events R-HSA-416476 9.149016e-01 0.039 1 0
Kidney development R-HSA-9830369 9.151840e-01 0.038 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.217321e-01 0.035 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.222647e-01 0.035 0 0
Ion channel transport R-HSA-983712 9.225928e-01 0.035 0 0
Translation of Structural Proteins R-HSA-9683701 9.228134e-01 0.035 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.260010e-01 0.033 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.260010e-01 0.033 0 0
Signaling by FGFR4 in disease R-HSA-5655291 9.260010e-01 0.033 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.260010e-01 0.033 0 0
Hydrolysis of LPC R-HSA-1483115 9.260010e-01 0.033 0 0
Biosynthesis of protectins R-HSA-9018681 9.260010e-01 0.033 0 0
Physiological factors R-HSA-5578768 9.260010e-01 0.033 0 0
Malate-aspartate shuttle R-HSA-9856872 9.260010e-01 0.033 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.260010e-01 0.033 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.260010e-01 0.033 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.260010e-01 0.033 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.260010e-01 0.033 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.260010e-01 0.033 0 0
P2Y receptors R-HSA-417957 9.260010e-01 0.033 0 0
HSF1-dependent transactivation R-HSA-3371571 9.272970e-01 0.033 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.278490e-01 0.033 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.296940e-01 0.032 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.296940e-01 0.032 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.302730e-01 0.031 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.303958e-01 0.031 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.303958e-01 0.031 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.323816e-01 0.030 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.325159e-01 0.030 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.349439e-01 0.029 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.359723e-01 0.029 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.359723e-01 0.029 0 0
Translesion synthesis by REV1 R-HSA-110312 9.359723e-01 0.029 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.359723e-01 0.029 0 0
Signaling by Activin R-HSA-1502540 9.359723e-01 0.029 0 0
Biotin transport and metabolism R-HSA-196780 9.359723e-01 0.029 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.359723e-01 0.029 0 0
Other semaphorin interactions R-HSA-416700 9.359723e-01 0.029 0 0
DNA Damage Reversal R-HSA-73942 9.359723e-01 0.029 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.377112e-01 0.028 0 0
Phospholipid metabolism R-HSA-1483257 9.378765e-01 0.028 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.381465e-01 0.028 0 0
G protein gated Potassium channels R-HSA-1296059 9.381465e-01 0.028 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.381465e-01 0.028 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.389444e-01 0.027 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.405891e-01 0.027 0 0
Selenoamino acid metabolism R-HSA-2408522 9.433613e-01 0.025 0 0
Translesion synthesis by POLI R-HSA-5656121 9.446004e-01 0.025 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.446004e-01 0.025 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.446004e-01 0.025 0 0
Fructose catabolism R-HSA-70350 9.446004e-01 0.025 0 0
MET activates PTK2 signaling R-HSA-8874081 9.450729e-01 0.025 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.450729e-01 0.025 0 0
RSV-host interactions R-HSA-9833110 9.459461e-01 0.024 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.466561e-01 0.024 0 0
Signaling by GPCR R-HSA-372790 9.467116e-01 0.024 1 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.471333e-01 0.024 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.471333e-01 0.024 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.472389e-01 0.024 0 0
Triglyceride catabolism R-HSA-163560 9.472389e-01 0.024 0 0
Ion transport by P-type ATPases R-HSA-936837 9.472612e-01 0.024 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.488857e-01 0.023 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.512562e-01 0.022 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.512562e-01 0.022 0 0
Signaling by BMP R-HSA-201451 9.512562e-01 0.022 0 0
Cristae formation R-HSA-8949613 9.512562e-01 0.022 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.512562e-01 0.022 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.520016e-01 0.021 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.520663e-01 0.021 0 0
Translesion synthesis by POLK R-HSA-5655862 9.520663e-01 0.021 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.520663e-01 0.021 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.520663e-01 0.021 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.520663e-01 0.021 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.520663e-01 0.021 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.520663e-01 0.021 0 0
Degradation of DVL R-HSA-4641258 9.525407e-01 0.021 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.564542e-01 0.019 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.567711e-01 0.019 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.567711e-01 0.019 0 0
Prednisone ADME R-HSA-9757110 9.567711e-01 0.019 0 0
Purine salvage R-HSA-74217 9.573413e-01 0.019 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.573413e-01 0.019 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.580245e-01 0.019 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.585265e-01 0.018 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.585265e-01 0.018 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.585265e-01 0.018 0 0
Catecholamine biosynthesis R-HSA-209905 9.585265e-01 0.018 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.585265e-01 0.018 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.585265e-01 0.018 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.607415e-01 0.017 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.616836e-01 0.017 0 0
Late endosomal microautophagy R-HSA-9615710 9.616852e-01 0.017 0 0
mRNA Capping R-HSA-72086 9.616852e-01 0.017 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.616852e-01 0.017 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.641163e-01 0.016 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.641163e-01 0.016 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.641163e-01 0.016 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.641163e-01 0.016 0 0
Nephron development R-HSA-9831926 9.641163e-01 0.016 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.656076e-01 0.015 0 0
Glycogen metabolism R-HSA-8982491 9.656076e-01 0.015 0 0
Neurotransmitter clearance R-HSA-112311 9.660603e-01 0.015 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.660603e-01 0.015 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.672696e-01 0.014 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.676227e-01 0.014 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.685209e-01 0.014 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.689530e-01 0.014 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.689530e-01 0.014 0 0
Translesion Synthesis by POLH R-HSA-110320 9.689530e-01 0.014 0 0
Methionine salvage pathway R-HSA-1237112 9.689530e-01 0.014 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.689530e-01 0.014 0 0
Maturation of spike protein R-HSA-9694548 9.691502e-01 0.014 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.699524e-01 0.013 0 0
Cargo concentration in the ER R-HSA-5694530 9.699524e-01 0.013 0 0
Collagen degradation R-HSA-1442490 9.705219e-01 0.013 0 0
The phototransduction cascade R-HSA-2514856 9.707081e-01 0.013 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.731380e-01 0.012 0 0
Creatine metabolism R-HSA-71288 9.731380e-01 0.012 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.731380e-01 0.012 0 0
Keratan sulfate degradation R-HSA-2022857 9.731380e-01 0.012 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.731380e-01 0.012 0 0
Pregnenolone biosynthesis R-HSA-196108 9.731380e-01 0.012 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.731686e-01 0.012 0 0
HS-GAG degradation R-HSA-2024096 9.734123e-01 0.012 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.735167e-01 0.012 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.735167e-01 0.012 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.736331e-01 0.012 0 0
Neurotransmitter release cycle R-HSA-112310 9.737405e-01 0.012 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.760712e-01 0.011 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.764856e-01 0.010 0 0
tRNA processing R-HSA-72306 9.766884e-01 0.010 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.767591e-01 0.010 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.767591e-01 0.010 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.767591e-01 0.010 0 0
Synthesis of DNA R-HSA-69239 9.768749e-01 0.010 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.778187e-01 0.010 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.778187e-01 0.010 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.780854e-01 0.010 1 0
Neddylation R-HSA-8951664 9.786728e-01 0.009 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.792137e-01 0.009 0 0
Heme degradation R-HSA-189483 9.792137e-01 0.009 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.795911e-01 0.009 0 0
Attachment and Entry R-HSA-9694614 9.798922e-01 0.009 0 0
Glutathione synthesis and recycling R-HSA-174403 9.798922e-01 0.009 0 0
Ribavirin ADME R-HSA-9755088 9.798922e-01 0.009 0 0
Assembly Of The HIV Virion R-HSA-175474 9.798922e-01 0.009 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.801520e-01 0.009 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.801520e-01 0.009 0 0
eNOS activation R-HSA-203615 9.816338e-01 0.008 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.816957e-01 0.008 0 0
Gastrulation R-HSA-9758941 9.818894e-01 0.008 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.819953e-01 0.008 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.824130e-01 0.008 0 0
SLC transporter disorders R-HSA-5619102 9.825565e-01 0.008 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.826031e-01 0.008 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.826031e-01 0.008 0 0
Fructose metabolism R-HSA-5652084 9.826031e-01 0.008 0 0
Translation of Structural Proteins R-HSA-9694635 9.832457e-01 0.007 0 0
Regulation of Apoptosis R-HSA-169911 9.837794e-01 0.007 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.837794e-01 0.007 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.841346e-01 0.007 0 0
Synthesis of PA R-HSA-1483166 9.841470e-01 0.007 0 0
Cholesterol biosynthesis R-HSA-191273 9.847242e-01 0.007 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.849487e-01 0.007 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.849487e-01 0.007 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.849487e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.849487e-01 0.007 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.849487e-01 0.007 0 0
Biosynthesis of maresins R-HSA-9018682 9.849487e-01 0.007 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.856804e-01 0.006 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.856804e-01 0.006 0 0
Glycosphingolipid transport R-HSA-9845576 9.856804e-01 0.006 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.858267e-01 0.006 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.860912e-01 0.006 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.869781e-01 0.006 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.869781e-01 0.006 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.869781e-01 0.006 0 0
Complex III assembly R-HSA-9865881 9.869781e-01 0.006 0 0
Triglyceride metabolism R-HSA-8979227 9.871401e-01 0.006 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.873638e-01 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.873638e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.873638e-01 0.006 0 0
Collagen chain trimerization R-HSA-8948216 9.873638e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.884268e-01 0.005 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.886499e-01 0.005 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.887340e-01 0.005 0 0
Hyaluronan degradation R-HSA-2160916 9.887340e-01 0.005 0 0
Laminin interactions R-HSA-3000157 9.887340e-01 0.005 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.887340e-01 0.005 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.887340e-01 0.005 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.888537e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.888537e-01 0.005 0 0
Nucleotide salvage R-HSA-8956321 9.895901e-01 0.005 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.898879e-01 0.004 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.901717e-01 0.004 0 0
Urea cycle R-HSA-70635 9.902533e-01 0.004 0 0
Abacavir ADME R-HSA-2161522 9.902533e-01 0.004 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.902533e-01 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.904510e-01 0.004 0 0
ABC-family proteins mediated transport R-HSA-382556 9.904606e-01 0.004 0 0
Mitochondrial protein import R-HSA-1268020 9.906412e-01 0.004 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.910176e-01 0.004 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.910176e-01 0.004 0 0
Attenuation phase R-HSA-3371568 9.913370e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.915677e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.915677e-01 0.004 0 0
Orc1 removal from chromatin R-HSA-68949 9.919949e-01 0.003 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.923668e-01 0.003 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.923668e-01 0.003 0 0
Pyrimidine salvage R-HSA-73614 9.927049e-01 0.003 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.932765e-01 0.003 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.932765e-01 0.003 0 0
G alpha (i) signalling events R-HSA-418594 9.933790e-01 0.003 1 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.936505e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.936888e-01 0.003 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.936888e-01 0.003 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.936888e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.944835e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.944835e-01 0.002 0 0
Mucopolysaccharidoses R-HSA-2206281 9.945401e-01 0.002 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.947887e-01 0.002 0 0
Defensins R-HSA-1461973 9.947887e-01 0.002 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.948949e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.951070e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.951425e-01 0.002 0 0
ER-Phagosome pathway R-HSA-1236974 9.951535e-01 0.002 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.952766e-01 0.002 0 0
Budding and maturation of HIV virion R-HSA-162588 9.952766e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.952766e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.954141e-01 0.002 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.959657e-01 0.002 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.959657e-01 0.002 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.959657e-01 0.002 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.959657e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.959657e-01 0.002 0 0
COPII-mediated vesicle transport R-HSA-204005 9.960720e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.960871e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.964675e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.967424e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.968619e-01 0.001 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.968619e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.968805e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.969419e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.970292e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.970292e-01 0.001 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.972133e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.972580e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.972580e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.973358e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.973545e-01 0.001 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.973545e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.973545e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.974808e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.977115e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.977704e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.980203e-01 0.001 0 0
HSF1 activation R-HSA-3371511 9.980203e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.980203e-01 0.001 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.981407e-01 0.001 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.982874e-01 0.001 0 0
Degradation of AXIN R-HSA-4641257 9.982874e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.982874e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.983940e-01 0.001 0 0
Protein localization R-HSA-9609507 9.984036e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.985185e-01 0.001 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.985667e-01 0.001 0 0
Downstream TCR signaling R-HSA-202424 9.986008e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.986431e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.987178e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.987185e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.987518e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.987518e-01 0.001 0 0
Disease R-HSA-1643685 9.988180e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.988914e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.989368e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.990315e-01 0.000 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.990411e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.990411e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.990474e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.990570e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.991505e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.991652e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.991652e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.991652e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.991652e-01 0.000 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.991705e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.992247e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.992612e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.993017e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.993468e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.993468e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.993586e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.993793e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.994229e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.994280e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.994631e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.994887e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.995113e-01 0.000 1 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.995356e-01 0.000 0 0
Somitogenesis R-HSA-9824272 9.995356e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.995983e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.996329e-01 0.000 0 0
PCP/CE pathway R-HSA-4086400 9.996470e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.996526e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.996625e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996625e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.996792e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.997401e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.997401e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.997479e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.997568e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.997733e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997733e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.997752e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998055e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998083e-01 0.000 1 1
Peroxisomal lipid metabolism R-HSA-390918 9.998327e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998480e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998607e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998670e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998852e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.998912e-01 0.000 0 0
Digestion R-HSA-8935690 9.999059e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999221e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999391e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.999391e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999473e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999545e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999633e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999653e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999659e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999659e-01 0.000 0 0
Translation R-HSA-72766 9.999732e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999745e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999809e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999812e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999830e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999835e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999863e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999865e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999882e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999908e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999920e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999920e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999943e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999948e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999954e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999954e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999961e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999964e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999967e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999970e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999970e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999976e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999977e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999988e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999991e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999996e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999996e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999996e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999998e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Signal Transduction R-HSA-162582 1.665335e-15 14.778 1 0
Mitotic Prophase R-HSA-68875 2.192690e-13 12.659 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.139977e-12 11.943 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.020595e-11 10.991 0 0
Cell Cycle Checkpoints R-HSA-69620 9.811818e-12 11.008 0 0
Cellular responses to stress R-HSA-2262752 1.091216e-11 10.962 1 0
Nervous system development R-HSA-9675108 1.281908e-11 10.892 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.541189e-11 10.812 0 0
Apoptotic execution phase R-HSA-75153 1.494393e-11 10.826 1 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.981793e-11 10.526 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.697742e-11 10.328 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.004452e-11 10.222 0 0
HCMV Early Events R-HSA-9609690 8.527046e-11 10.069 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.069734e-10 9.971 0 0
Mitotic Prometaphase R-HSA-68877 1.375176e-10 9.862 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.406806e-10 9.852 0 0
Cellular responses to stimuli R-HSA-8953897 1.548457e-10 9.810 1 0
Axon guidance R-HSA-422475 1.609483e-10 9.793 0 0
DNA methylation R-HSA-5334118 3.976558e-10 9.400 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.235975e-10 9.373 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.276336e-10 9.278 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.035829e-10 9.219 0 0
Mitotic Anaphase R-HSA-68882 1.021168e-09 8.991 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.190914e-09 8.924 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.254134e-09 8.902 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.723560e-09 8.764 0 0
HDACs deacetylate histones R-HSA-3214815 1.988388e-09 8.701 0 0
Cell-Cell communication R-HSA-1500931 2.443899e-09 8.612 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.462719e-09 8.609 0 0
Defective pyroptosis R-HSA-9710421 2.650567e-09 8.577 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.605085e-09 8.584 0 0
Diseases of programmed cell death R-HSA-9645723 2.763801e-09 8.558 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.412447e-09 8.467 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.048174e-09 8.393 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.012790e-09 8.397 0 0
Gene Silencing by RNA R-HSA-211000 3.993950e-09 8.399 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.384527e-09 8.358 0 0
Packaging Of Telomere Ends R-HSA-171306 5.120050e-09 8.291 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.118960e-09 8.213 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.118960e-09 8.213 0 0
HCMV Infection R-HSA-9609646 9.503330e-09 8.022 0 0
Meiotic recombination R-HSA-912446 9.630065e-09 8.016 0 0
Recycling pathway of L1 R-HSA-437239 1.094399e-08 7.961 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.311559e-08 7.882 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.399016e-08 7.854 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.484382e-08 7.828 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.524531e-08 7.817 0 0
G2/M Checkpoints R-HSA-69481 1.587815e-08 7.799 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.896517e-08 7.722 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.514618e-08 7.600 0 0
Cell junction organization R-HSA-446728 2.921770e-08 7.534 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.236484e-08 7.490 0 0
Cellular Senescence R-HSA-2559583 3.516095e-08 7.454 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.583796e-08 7.339 1 1
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.583796e-08 7.339 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.365612e-08 7.270 0 0
HATs acetylate histones R-HSA-3214847 5.470333e-08 7.262 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.437871e-08 7.074 0 0
RNA Polymerase I Transcription R-HSA-73864 8.711254e-08 7.060 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.338307e-08 7.030 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.379970e-07 6.860 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.392366e-07 6.856 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.404093e-07 6.853 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.573251e-07 6.803 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.634840e-07 6.787 0 0
Depyrimidination R-HSA-73928 1.634840e-07 6.787 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.858876e-07 6.731 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.858876e-07 6.731 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.107829e-07 6.676 0 0
Separation of Sister Chromatids R-HSA-2467813 2.567215e-07 6.591 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.662684e-07 6.575 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.045955e-07 6.516 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.012435e-07 6.521 0 0
L1CAM interactions R-HSA-373760 3.075956e-07 6.512 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.182551e-07 6.497 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.247722e-07 6.488 0 0
Signaling by ALK in cancer R-HSA-9700206 3.247722e-07 6.488 0 0
Gap junction trafficking and regulation R-HSA-157858 3.425749e-07 6.465 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.610920e-07 6.442 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.143710e-07 6.383 0 0
Nucleosome assembly R-HSA-774815 4.143710e-07 6.383 0 0
Cleavage of the damaged purine R-HSA-110331 4.137571e-07 6.383 0 0
Kinesins R-HSA-983189 4.957411e-07 6.305 0 0
Depurination R-HSA-73927 5.752585e-07 6.240 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.901618e-07 6.229 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.733120e-07 6.172 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.914672e-07 6.160 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.790288e-07 6.108 0 0
Chromatin organization R-HSA-4839726 9.791369e-07 6.009 0 0
Apoptosis R-HSA-109581 1.123937e-06 5.949 1 0
Gap junction trafficking R-HSA-190828 1.207701e-06 5.918 0 0
Programmed Cell Death R-HSA-5357801 1.220603e-06 5.913 1 0
Meiosis R-HSA-1500620 1.288280e-06 5.890 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.454136e-06 5.837 0 0
Chromatin modifying enzymes R-HSA-3247509 1.699168e-06 5.770 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.029854e-06 5.693 0 0
ESR-mediated signaling R-HSA-8939211 2.375125e-06 5.624 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.794492e-06 5.554 0 0
Nuclear import of Rev protein R-HSA-180746 2.803660e-06 5.552 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.814849e-06 5.551 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.048523e-06 5.516 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.599953e-06 5.444 0 0
Meiotic synapsis R-HSA-1221632 3.630878e-06 5.440 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.842859e-06 5.415 0 0
Aggrephagy R-HSA-9646399 4.271211e-06 5.369 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.509028e-06 5.346 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.633688e-06 5.334 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.123194e-06 5.290 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.001656e-06 5.301 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.112088e-06 5.291 0 0
Adherens junctions interactions R-HSA-418990 5.544613e-06 5.256 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.612858e-06 5.251 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.612858e-06 5.251 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.187798e-06 5.208 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.195751e-06 5.208 0 0
HCMV Late Events R-HSA-9610379 7.219483e-06 5.141 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 9.964280e-06 5.002 0 0
Cell-cell junction organization R-HSA-421270 1.031832e-05 4.986 0 0
Gap junction assembly R-HSA-190861 1.135905e-05 4.945 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.222695e-05 4.913 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.295772e-05 4.887 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.295772e-05 4.887 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.365344e-05 4.865 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.365344e-05 4.865 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.365344e-05 4.865 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.600144e-05 4.796 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.600144e-05 4.796 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.601684e-05 4.795 0 0
Membrane Trafficking R-HSA-199991 1.706326e-05 4.768 0 0
Telomere Maintenance R-HSA-157579 1.936170e-05 4.713 0 0
DNA Replication R-HSA-69306 2.197997e-05 4.658 0 0
DNA Double Strand Break Response R-HSA-5693606 2.469292e-05 4.607 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.482372e-05 4.605 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.484570e-05 4.605 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.634137e-05 4.579 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.011721e-05 4.521 0 0
Chromosome Maintenance R-HSA-73886 2.887200e-05 4.540 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.804937e-05 4.552 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.105049e-05 4.508 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.297401e-05 4.482 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.427952e-05 4.465 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.594350e-05 4.444 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.768933e-05 4.424 0 0
Amyloid fiber formation R-HSA-977225 4.041942e-05 4.393 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.148230e-05 4.382 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.206281e-05 4.376 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.438604e-05 4.353 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.785581e-05 4.320 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.785581e-05 4.320 0 0
Homology Directed Repair R-HSA-5693538 4.509499e-05 4.346 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.426085e-05 4.354 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.809427e-05 4.318 0 0
Metabolism of RNA R-HSA-8953854 5.339773e-05 4.272 1 0
Reproduction R-HSA-1474165 5.379193e-05 4.269 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.660149e-05 4.247 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.672063e-05 4.246 0 0
Selective autophagy R-HSA-9663891 5.756816e-05 4.240 0 0
Signaling by ROBO receptors R-HSA-376176 7.330601e-05 4.135 0 0
Base Excision Repair R-HSA-73884 7.885480e-05 4.103 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.030168e-05 4.095 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.030168e-05 4.095 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.805327e-05 4.055 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.805327e-05 4.055 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.157853e-05 4.038 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.652292e-05 4.015 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.652292e-05 4.015 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.025942e-04 3.989 0 0
Activation of ATR in response to replication stress R-HSA-176187 9.356480e-05 4.029 0 0
Influenza Infection R-HSA-168255 1.032160e-04 3.986 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.092611e-04 3.962 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.174813e-04 3.930 0 0
EPH-Ephrin signaling R-HSA-2682334 1.240591e-04 3.906 0 0
Post NMDA receptor activation events R-HSA-438064 1.255731e-04 3.901 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.295852e-04 3.887 1 0
Signaling by Hippo R-HSA-2028269 1.454134e-04 3.837 0 0
Activation of the pre-replicative complex R-HSA-68962 1.548655e-04 3.810 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.651578e-04 3.782 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.967505e-04 3.706 0 0
Ephrin signaling R-HSA-3928664 2.066780e-04 3.685 0 0
G2/M Transition R-HSA-69275 2.073021e-04 3.683 0 0
PKR-mediated signaling R-HSA-9833482 2.346530e-04 3.630 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.364423e-04 3.626 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.508453e-04 3.601 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.519146e-04 3.599 0 0
Viral Infection Pathways R-HSA-9824446 2.705414e-04 3.568 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.750770e-04 3.561 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.998112e-04 3.523 0 0
mRNA Splicing R-HSA-72172 3.278321e-04 3.484 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.563368e-04 3.448 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.563368e-04 3.448 0 0
DNA Repair R-HSA-73894 3.637651e-04 3.439 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.232355e-04 3.373 0 0
Glycolysis R-HSA-70171 4.269608e-04 3.370 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.693244e-04 3.329 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.839860e-04 3.315 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.117940e-04 3.291 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.491370e-04 3.260 0 0
Developmental Biology R-HSA-1266738 5.528633e-04 3.257 0 0
tRNA processing in the nucleus R-HSA-6784531 6.031428e-04 3.220 0 0
HIV Life Cycle R-HSA-162587 6.378436e-04 3.195 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.493046e-04 3.188 0 0
Centrosome maturation R-HSA-380287 6.873121e-04 3.163 0 0
Signaling by PTK6 R-HSA-8848021 7.073248e-04 3.150 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.073248e-04 3.150 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.815139e-04 3.107 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 9.225279e-04 3.035 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.272985e-04 3.082 0 0
MHC class II antigen presentation R-HSA-2132295 8.813772e-04 3.055 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.845086e-04 3.053 0 0
snRNP Assembly R-HSA-191859 9.708726e-04 3.013 0 0
Metabolism of non-coding RNA R-HSA-194441 9.708726e-04 3.013 0 0
Signaling by NTRKs R-HSA-166520 1.022227e-03 2.990 0 0
Signaling by NOTCH R-HSA-157118 1.040554e-03 2.983 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.115250e-03 2.953 0 0
Translation initiation complex formation R-HSA-72649 1.135978e-03 2.945 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.145735e-03 2.941 0 0
Gene expression (Transcription) R-HSA-74160 1.280469e-03 2.893 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.322351e-03 2.879 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.334160e-03 2.875 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.429894e-03 2.845 0 0
Cellular response to heat stress R-HSA-3371556 1.458158e-03 2.836 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.560705e-03 2.807 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.663295e-03 2.779 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.728329e-03 2.762 0 0
Deubiquitination R-HSA-5688426 1.779590e-03 2.750 0 0
Macroautophagy R-HSA-1632852 1.796938e-03 2.745 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.822936e-03 2.739 0 0
Peptide chain elongation R-HSA-156902 1.877765e-03 2.726 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.891504e-03 2.723 0 0
Autophagy R-HSA-9612973 2.106402e-03 2.676 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.155920e-03 2.666 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.393370e-03 2.621 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.393370e-03 2.621 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.393370e-03 2.621 0 0
Metalloprotease DUBs R-HSA-5689901 2.444789e-03 2.612 0 0
Smooth Muscle Contraction R-HSA-445355 2.504946e-03 2.601 0 0
Cellular response to chemical stress R-HSA-9711123 2.548843e-03 2.594 1 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.860146e-03 2.544 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.560949e-03 2.592 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.667072e-03 2.574 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.985540e-03 2.525 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.622530e-03 2.581 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.127722e-03 2.505 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.169940e-03 2.499 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.182492e-03 2.497 1 0
Protein folding R-HSA-391251 3.335316e-03 2.477 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.508295e-03 2.455 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.704001e-03 2.431 0 0
Glucose metabolism R-HSA-70326 3.852538e-03 2.414 0 0
Inositol phosphate metabolism R-HSA-1483249 3.853855e-03 2.414 0 0
NRAGE signals death through JNK R-HSA-193648 3.876895e-03 2.412 0 0
Signaling by WNT R-HSA-195721 3.878382e-03 2.411 0 0
Striated Muscle Contraction R-HSA-390522 3.986647e-03 2.399 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.093902e-03 2.388 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.114349e-03 2.386 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.596307e-03 2.338 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.095426e-03 2.293 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.104424e-03 2.292 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.134171e-03 2.290 0 0
G alpha (12/13) signalling events R-HSA-416482 5.313208e-03 2.275 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.527134e-03 2.257 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.556059e-03 2.255 0 0
Activation of RAC1 R-HSA-428540 5.556059e-03 2.255 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.559588e-03 2.255 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.669425e-03 2.246 0 0
Cilium Assembly R-HSA-5617833 5.734897e-03 2.241 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.414898e-03 2.193 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.447703e-03 2.191 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.583609e-03 2.182 0 0
Formation of annular gap junctions R-HSA-196025 6.583609e-03 2.182 0 0
Adrenoceptors R-HSA-390696 6.583609e-03 2.182 0 0
Signaling by ERBB2 R-HSA-1227986 6.603364e-03 2.180 1 0
Co-inhibition by PD-1 R-HSA-389948 6.765211e-03 2.170 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.870469e-03 2.163 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.438088e-03 2.129 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.438088e-03 2.129 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.602796e-03 2.119 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 9.004525e-03 2.046 0 0
Ribosome-associated quality control R-HSA-9948299 8.729703e-03 2.059 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.867006e-03 2.104 0 0
UCH proteinases R-HSA-5689603 9.006970e-03 2.045 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.867006e-03 2.104 0 0
Signaling by VEGF R-HSA-194138 8.506233e-03 2.070 1 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 8.603987e-03 2.065 0 0
Ub-specific processing proteases R-HSA-5689880 8.492492e-03 2.071 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.162230e-03 2.038 0 0
HIV Infection R-HSA-162906 9.227826e-03 2.035 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.312799e-03 2.031 0 0
Gap junction degradation R-HSA-190873 9.348382e-03 2.029 0 0
ALK mutants bind TKIs R-HSA-9700645 9.348382e-03 2.029 0 0
Muscle contraction R-HSA-397014 9.520758e-03 2.021 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.842354e-03 2.007 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 9.901460e-03 2.004 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.008288e-02 1.996 1 0
Eukaryotic Translation Termination R-HSA-72764 1.008793e-02 1.996 0 0
mTORC1-mediated signalling R-HSA-166208 1.052663e-02 1.978 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.063783e-02 1.973 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.063783e-02 1.973 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.095177e-02 1.961 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.095177e-02 1.961 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.109403e-02 1.955 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.183281e-02 1.927 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.220775e-02 1.913 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.282303e-02 1.892 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.337490e-02 1.874 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.337490e-02 1.874 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.337490e-02 1.874 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.337490e-02 1.874 0 0
Signaling by RAS mutants R-HSA-6802949 1.337490e-02 1.874 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.363829e-02 1.865 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.376883e-02 1.861 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.406497e-02 1.852 1 1
PKMTs methylate histone lysines R-HSA-3214841 1.419466e-02 1.848 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.446017e-02 1.840 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.506461e-02 1.822 0 0
G1/S Transition R-HSA-69206 1.520926e-02 1.818 0 0
Neurodegenerative Diseases R-HSA-8863678 1.529943e-02 1.815 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.529943e-02 1.815 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.530100e-02 1.815 1 1
Activation of BH3-only proteins R-HSA-114452 1.530100e-02 1.815 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.538615e-02 1.813 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.571287e-02 1.804 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.571287e-02 1.804 0 0
MAP2K and MAPK activation R-HSA-5674135 1.625220e-02 1.789 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.628979e-02 1.788 0 0
MET interacts with TNS proteins R-HSA-8875513 1.628979e-02 1.788 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.670062e-02 1.777 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.707944e-02 1.768 0 0
Selenocysteine synthesis R-HSA-2408557 1.714552e-02 1.766 0 0
Interferon Signaling R-HSA-913531 1.716194e-02 1.765 1 0
Vesicle-mediated transport R-HSA-5653656 1.792757e-02 1.746 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.819892e-02 1.740 0 0
MTOR signalling R-HSA-165159 1.852510e-02 1.732 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.914636e-02 1.718 0 0
Signaling by EGFR R-HSA-177929 1.995680e-02 1.700 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.995680e-02 1.700 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.209147e-02 1.656 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.209147e-02 1.656 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.218028e-02 1.654 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.478121e-02 1.606 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.211867e-02 1.655 0 0
Viral mRNA Translation R-HSA-192823 2.020518e-02 1.695 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.188520e-02 1.660 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.176062e-02 1.662 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.494816e-02 1.603 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.494816e-02 1.603 0 0
RMTs methylate histone arginines R-HSA-3214858 2.376584e-02 1.624 0 0
Host Interactions of HIV factors R-HSA-162909 2.278872e-02 1.642 0 0
Semaphorin interactions R-HSA-373755 2.021961e-02 1.694 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.514063e-02 1.600 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.562303e-02 1.591 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.572377e-02 1.590 0 0
Regulation of gap junction activity R-HSA-191650 2.608414e-02 1.584 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.608414e-02 1.584 0 0
FOXO-mediated transcription R-HSA-9614085 2.647233e-02 1.577 0 0
Signaling by MET R-HSA-6806834 2.650400e-02 1.577 0 0
mRNA 3'-end processing R-HSA-72187 2.729258e-02 1.564 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.729258e-02 1.564 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.760068e-02 1.559 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.817787e-02 1.550 0 0
Pervasive developmental disorders R-HSA-9005895 2.817787e-02 1.550 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.817787e-02 1.550 0 0
Disorders of Nervous System Development R-HSA-9697154 2.817787e-02 1.550 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.817787e-02 1.550 0 0
Signaling by LTK R-HSA-9842663 2.817787e-02 1.550 0 0
Type I hemidesmosome assembly R-HSA-446107 2.984583e-02 1.525 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.142248e-02 1.503 0 0
S Phase R-HSA-69242 3.149034e-02 1.502 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.152790e-02 1.501 0 0
FLT3 Signaling R-HSA-9607240 3.287953e-02 1.483 0 0
RNA Polymerase II Transcription R-HSA-73857 3.295319e-02 1.482 0 0
Cytoprotection by HMOX1 R-HSA-9707564 3.425541e-02 1.465 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.459384e-02 1.461 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.631165e-02 1.440 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.693549e-02 1.433 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.729725e-02 1.428 0 0
Intraflagellar transport R-HSA-5620924 3.734919e-02 1.428 0 0
NGF-stimulated transcription R-HSA-9031628 3.734919e-02 1.428 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 3.839989e-02 1.416 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.871854e-02 1.412 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.901916e-02 1.409 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.901916e-02 1.409 0 0
WNT mediated activation of DVL R-HSA-201688 3.901916e-02 1.409 0 0
Unwinding of DNA R-HSA-176974 3.901916e-02 1.409 0 0
Oligomerization of connexins into connexons R-HSA-190704 4.023526e-02 1.395 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.023526e-02 1.395 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 4.023526e-02 1.395 0 0
Transport of connexins along the secretory pathway R-HSA-190827 4.023526e-02 1.395 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.023526e-02 1.395 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.105970e-02 1.387 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.132521e-02 1.384 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.145235e-02 1.382 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.301632e-02 1.366 0 0
Regulation of KIT signaling R-HSA-1433559 4.301632e-02 1.366 0 0
EGFR downregulation R-HSA-182971 4.415836e-02 1.355 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.415836e-02 1.355 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.455081e-02 1.351 0 0
TGFBR3 expression R-HSA-9839394 4.765267e-02 1.322 0 0
HDMs demethylate histones R-HSA-3214842 4.765267e-02 1.322 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.827790e-02 1.316 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.962728e-02 1.304 0 0
Signaling by Leptin R-HSA-2586552 4.962728e-02 1.304 0 0
DNA strand elongation R-HSA-69190 5.007809e-02 1.300 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 5.114487e-02 1.291 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.173340e-02 1.286 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.190485e-02 1.285 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.190485e-02 1.285 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.190485e-02 1.285 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.285074e-02 1.277 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.460080e-02 1.263 0 0
MAPK family signaling cascades R-HSA-5683057 5.546920e-02 1.256 0 0
Integrin signaling R-HSA-354192 5.648805e-02 1.248 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.648805e-02 1.248 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.648805e-02 1.248 0 0
Regulation of TP53 Expression R-HSA-6804754 6.684925e-02 1.175 0 0
Signaling by APC mutants R-HSA-4839744 6.166092e-02 1.210 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.166092e-02 1.210 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.166092e-02 1.210 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.166092e-02 1.210 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.508840e-02 1.124 0 0
Notch-HLH transcription pathway R-HSA-350054 7.751176e-02 1.111 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.751176e-02 1.111 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.214895e-02 1.207 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.339609e-02 1.198 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.859059e-02 1.164 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.723112e-02 1.172 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.751176e-02 1.111 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.906281e-02 1.102 0 0
Disorders of Developmental Biology R-HSA-9675151 7.265426e-02 1.139 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.776972e-02 1.169 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 6.684925e-02 1.175 0 0
Generic Transcription Pathway R-HSA-212436 6.631016e-02 1.178 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.872524e-02 1.104 0 0
Interleukin-2 family signaling R-HSA-451927 6.332084e-02 1.198 0 0
rRNA processing R-HSA-72312 6.159074e-02 1.210 0 0
Signaling by AXIN mutants R-HSA-4839735 7.508840e-02 1.124 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.438587e-02 1.191 0 0
Adaptive Immune System R-HSA-1280218 7.878378e-02 1.104 0 0
Death Receptor Signaling R-HSA-73887 6.854007e-02 1.164 0 0
ChREBP activates metabolic gene expression R-HSA-163765 6.166092e-02 1.210 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.072482e-02 1.217 0 0
Hedgehog 'off' state R-HSA-5610787 8.231439e-02 1.085 0 0
Cellular response to starvation R-HSA-9711097 8.339827e-02 1.079 0 0
Regulation of CDH1 Function R-HSA-9764561 8.566435e-02 1.067 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.566435e-02 1.067 0 0
G1/S-Specific Transcription R-HSA-69205 8.714934e-02 1.060 0 0
RET signaling R-HSA-8853659 8.714934e-02 1.060 0 0
Growth hormone receptor signaling R-HSA-982772 8.800072e-02 1.056 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.842783e-02 1.053 0 0
Interleukin-37 signaling R-HSA-9008059 8.842783e-02 1.053 0 0
PTK6 Expression R-HSA-8849473 8.945017e-02 1.048 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 8.945017e-02 1.048 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.985857e-02 1.046 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.985857e-02 1.046 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.985857e-02 1.046 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.985857e-02 1.046 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.985857e-02 1.046 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.985857e-02 1.046 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.985857e-02 1.046 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.985857e-02 1.046 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.985857e-02 1.046 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 9.728753e-02 1.012 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 9.768016e-02 1.010 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 9.768016e-02 1.010 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.922450e-02 1.003 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.957693e-02 1.002 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.957693e-02 1.002 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.957693e-02 1.002 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.957693e-02 1.002 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.033103e-01 0.986 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.059037e-01 0.975 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.059037e-01 0.975 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.077249e-01 0.968 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.079862e-01 0.967 0 0
Hemostasis R-HSA-109582 1.097842e-01 0.959 1 0
Signaling by NOTCH1 R-HSA-1980143 1.103096e-01 0.957 0 0
Interleukin-12 signaling R-HSA-9020591 1.103096e-01 0.957 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.103692e-01 0.957 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.103996e-01 0.957 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.105825e-01 0.956 0 0
Signaling by ALK R-HSA-201556 1.154244e-01 0.938 0 0
SARS-CoV Infections R-HSA-9679506 1.183945e-01 0.927 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.200746e-01 0.921 0 0
Removal of the Flap Intermediate R-HSA-69166 1.231426e-01 0.910 0 0
Signal regulatory protein family interactions R-HSA-391160 1.231426e-01 0.910 0 0
Heme signaling R-HSA-9707616 1.240998e-01 0.906 0 0
Nephrin family interactions R-HSA-373753 1.255790e-01 0.901 0 0
Negative regulation of MET activity R-HSA-6807004 1.255790e-01 0.901 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.892436e-01 0.723 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.892436e-01 0.723 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.892436e-01 0.723 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.892436e-01 0.723 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.892436e-01 0.723 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.892436e-01 0.723 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.892436e-01 0.723 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.892436e-01 0.723 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.892436e-01 0.723 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.892436e-01 0.723 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.316253e-01 0.881 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.316253e-01 0.881 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.316253e-01 0.881 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.316253e-01 0.881 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.316253e-01 0.881 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.316253e-01 0.881 0 0
PTK6 Activates STAT3 R-HSA-8849474 1.677596e-01 0.775 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.677596e-01 0.775 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.677596e-01 0.775 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.677596e-01 0.775 0 0
IRS activation R-HSA-74713 1.677596e-01 0.775 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.677596e-01 0.775 0 0
PTK6 Down-Regulation R-HSA-8849472 1.677596e-01 0.775 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.677596e-01 0.775 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.677596e-01 0.775 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.677596e-01 0.775 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.334107e-01 0.875 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.576992e-01 0.802 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.576992e-01 0.802 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.832117e-01 0.737 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.414832e-01 0.849 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.414832e-01 0.849 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.608254e-01 0.794 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.810631e-01 0.742 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.810631e-01 0.742 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.371065e-01 0.863 0 0
FGFR2 alternative splicing R-HSA-6803529 1.740864e-01 0.759 0 0
HIV elongation arrest and recovery R-HSA-167287 1.510483e-01 0.821 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.510483e-01 0.821 0 0
Late endosomal microautophagy R-HSA-9615710 1.655930e-01 0.781 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.655930e-01 0.781 0 0
RAF activation R-HSA-5673000 1.439969e-01 0.842 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.841100e-01 0.735 0 0
Nucleotide Excision Repair R-HSA-5696398 1.751500e-01 0.757 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.595207e-01 0.797 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.758595e-01 0.755 0 0
Signal attenuation R-HSA-74749 1.576992e-01 0.802 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.414832e-01 0.849 0 0
HSF1 activation R-HSA-3371511 1.699962e-01 0.770 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.334107e-01 0.875 0 0
DCC mediated attractive signaling R-HSA-418885 1.414832e-01 0.849 0 0
Developmental Cell Lineages R-HSA-9734767 1.843592e-01 0.734 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.316253e-01 0.881 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.597966e-01 0.796 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.439969e-01 0.842 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.334107e-01 0.875 0 0
Regulation of TP53 Activity R-HSA-5633007 1.319350e-01 0.880 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.366985e-01 0.864 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.597966e-01 0.796 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.655930e-01 0.781 0 0
TBC/RABGAPs R-HSA-8854214 1.719887e-01 0.765 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.827571e-01 0.738 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.827571e-01 0.738 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.827571e-01 0.738 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.827571e-01 0.738 0 0
Signaling by SCF-KIT R-HSA-1433557 1.719887e-01 0.765 0 0
Regulated Necrosis R-HSA-5218859 1.808154e-01 0.743 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.892436e-01 0.723 0 0
Inhibition of PKR R-HSA-169131 1.892436e-01 0.723 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.316253e-01 0.881 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.316253e-01 0.881 0 0
Negative regulation of FLT3 R-HSA-9706369 1.608254e-01 0.794 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.571799e-01 0.804 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.407460e-01 0.852 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.334107e-01 0.875 0 0
ERK/MAPK targets R-HSA-198753 1.409915e-01 0.851 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.726597e-01 0.763 0 0
Signaling by TGFB family members R-HSA-9006936 1.839439e-01 0.735 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.655930e-01 0.781 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.701412e-01 0.769 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.827571e-01 0.738 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.576992e-01 0.802 0 0
Interleukin-2 signaling R-HSA-9020558 1.832117e-01 0.737 0 0
Basigin interactions R-HSA-210991 1.409915e-01 0.851 0 0
PECAM1 interactions R-HSA-210990 1.832117e-01 0.737 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.810631e-01 0.742 0 0
Protein ubiquitination R-HSA-8852135 1.688653e-01 0.772 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.409915e-01 0.851 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.414832e-01 0.849 0 0
Interleukin-12 family signaling R-HSA-447115 1.399789e-01 0.854 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.322980e-01 0.878 0 0
IRE1alpha activates chaperones R-HSA-381070 1.818974e-01 0.740 0 0
Syndecan interactions R-HSA-3000170 1.916498e-01 0.717 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.947201e-01 0.711 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.961149e-01 0.707 0 0
MET promotes cell motility R-HSA-8875878 1.978704e-01 0.704 0 0
Signaling by Interleukins R-HSA-449147 1.998824e-01 0.699 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.020871e-01 0.694 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.020871e-01 0.694 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.020871e-01 0.694 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.020871e-01 0.694 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.020871e-01 0.694 0 0
Specification of primordial germ cells R-HSA-9827857 2.020871e-01 0.694 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.053112e-01 0.688 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.053112e-01 0.688 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.053112e-01 0.688 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.053112e-01 0.688 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.053112e-01 0.688 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.053112e-01 0.688 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.053112e-01 0.688 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.097164e-01 0.678 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.097164e-01 0.678 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.097164e-01 0.678 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.097164e-01 0.678 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.097164e-01 0.678 0 0
Deadenylation of mRNA R-HSA-429947 2.098057e-01 0.678 0 0
Signaling by TGFBR3 R-HSA-9839373 2.108984e-01 0.676 0 0
Diseases of DNA repair R-HSA-9675135 2.108984e-01 0.676 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.124545e-01 0.673 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.124545e-01 0.673 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.146400e-01 0.668 0 0
Circadian clock R-HSA-9909396 2.184525e-01 0.661 0 0
Rab regulation of trafficking R-HSA-9007101 2.212607e-01 0.655 0 0
Mitochondrial biogenesis R-HSA-1592230 2.212607e-01 0.655 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.237863e-01 0.650 0 0
GAB1 signalosome R-HSA-180292 2.237863e-01 0.650 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.237863e-01 0.650 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.237863e-01 0.650 0 0
Mismatch Repair R-HSA-5358508 2.237863e-01 0.650 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.273857e-01 0.643 0 0
Interleukin-7 signaling R-HSA-1266695 2.284879e-01 0.641 0 0
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 R-HSA-9916720 2.699857e-01 0.569 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.699857e-01 0.569 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.699857e-01 0.569 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.699857e-01 0.569 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.699857e-01 0.569 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.699857e-01 0.569 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.699857e-01 0.569 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.426911e-01 0.465 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.426911e-01 0.465 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.426911e-01 0.465 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.426911e-01 0.465 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.426911e-01 0.465 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.426911e-01 0.465 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.426911e-01 0.465 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.426911e-01 0.465 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.426911e-01 0.465 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.426911e-01 0.465 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.426911e-01 0.465 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.426911e-01 0.465 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.426911e-01 0.465 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.426911e-01 0.465 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.426911e-01 0.465 0 0
Potassium transport channels R-HSA-1296067 3.426911e-01 0.465 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.426911e-01 0.465 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.436399e-01 0.613 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.436399e-01 0.613 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.822190e-01 0.549 0 0
SOS-mediated signalling R-HSA-112412 2.822190e-01 0.549 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.822190e-01 0.549 0 0
Recycling of eIF2:GDP R-HSA-72731 2.822190e-01 0.549 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.822190e-01 0.549 0 0
MET activates STAT3 R-HSA-8875791 4.081594e-01 0.389 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.081594e-01 0.389 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.081594e-01 0.389 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.081594e-01 0.389 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.081594e-01 0.389 0 0
MET activates PTPN11 R-HSA-8865999 4.081594e-01 0.389 0 0
Invadopodia formation R-HSA-8941237 4.081594e-01 0.389 0 0
Signalling to STAT3 R-HSA-198745 4.081594e-01 0.389 0 0
Classical Kir channels R-HSA-1296053 4.081594e-01 0.389 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.369905e-01 0.625 0 0
Polymerase switching R-HSA-69091 2.369905e-01 0.625 0 0
Leading Strand Synthesis R-HSA-69109 2.369905e-01 0.625 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.206189e-01 0.494 0 0
RSK activation R-HSA-444257 3.206189e-01 0.494 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.206189e-01 0.494 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.206189e-01 0.494 0 0
MET receptor recycling R-HSA-8875656 3.206189e-01 0.494 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.206189e-01 0.494 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.648228e-01 0.577 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.648228e-01 0.577 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.460499e-01 0.609 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.584929e-01 0.446 1 1
Interleukin-21 signaling R-HSA-9020958 3.584929e-01 0.446 0 0
Lipophagy R-HSA-9613354 3.584929e-01 0.446 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.687685e-01 0.571 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.687685e-01 0.571 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.687685e-01 0.571 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.213894e-01 0.493 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.213894e-01 0.493 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.213894e-01 0.493 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.476290e-01 0.606 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.955650e-01 0.403 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.955650e-01 0.403 0 0
2-LTR circle formation R-HSA-164843 3.955650e-01 0.403 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.955650e-01 0.403 0 0
DNA replication initiation R-HSA-68952 3.955650e-01 0.403 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.671613e-01 0.573 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.671613e-01 0.573 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.497763e-01 0.456 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.780276e-01 0.422 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.316195e-01 0.365 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.316195e-01 0.365 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.621251e-01 0.441 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.060101e-01 0.391 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.060101e-01 0.391 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.397977e-01 0.469 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.716883e-01 0.430 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.988219e-01 0.525 0 0
Signaling by ERBB4 R-HSA-1236394 3.600142e-01 0.444 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.297091e-01 0.367 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.550922e-01 0.342 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.550922e-01 0.342 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.550922e-01 0.342 0 0
Transcription of the HIV genome R-HSA-167172 4.034556e-01 0.394 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.321639e-01 0.364 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.918356e-01 0.535 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.918356e-01 0.535 0 0
DAP12 signaling R-HSA-2424491 3.274349e-01 0.485 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.426792e-01 0.615 0 0
Polo-like kinase mediated events R-HSA-156711 4.336064e-01 0.363 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.988219e-01 0.525 0 0
Lagging Strand Synthesis R-HSA-69186 2.918356e-01 0.535 0 0
Signalling to RAS R-HSA-167044 2.918356e-01 0.535 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.595542e-01 0.444 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.476290e-01 0.606 0 0
IGF1R signaling cascade R-HSA-2428924 3.450313e-01 0.462 0 0
DNA Damage Bypass R-HSA-73893 3.902497e-01 0.409 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.349594e-01 0.475 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.085345e-01 0.389 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.532881e-01 0.452 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.856090e-01 0.414 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.085345e-01 0.389 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.686825e-01 0.433 0 0
Synthesis of DNA R-HSA-69239 2.726330e-01 0.564 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.290097e-01 0.640 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.822190e-01 0.549 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.822190e-01 0.549 0 0
p38MAPK events R-HSA-171007 3.213894e-01 0.493 0 0
Regulation of CDH11 function R-HSA-9762292 3.955650e-01 0.403 0 0
PI3K/AKT activation R-HSA-198203 3.955650e-01 0.403 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.671613e-01 0.573 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.497763e-01 0.456 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.357633e-01 0.628 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.460499e-01 0.609 0 0
Telomere C-strand synthesis initiation R-HSA-174430 3.213894e-01 0.493 0 0
Binding and entry of HIV virion R-HSA-173107 3.955650e-01 0.403 0 0
DARPP-32 events R-HSA-180024 3.071301e-01 0.513 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.386093e-01 0.470 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.327212e-01 0.478 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.327212e-01 0.478 1 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.574935e-01 0.340 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.766049e-01 0.424 1 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.887876e-01 0.410 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.886595e-01 0.410 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.327212e-01 0.478 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.930163e-01 0.533 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.930163e-01 0.533 0 0
Calcineurin activates NFAT R-HSA-2025928 3.584929e-01 0.446 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.290097e-01 0.640 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.497763e-01 0.456 0 0
Killing mechanisms R-HSA-9664420 3.497763e-01 0.456 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.780276e-01 0.422 0 0
Formation of the posterior neural plate R-HSA-9832991 4.316195e-01 0.365 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.274349e-01 0.485 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.089801e-01 0.388 0 0
Tight junction interactions R-HSA-420029 4.089801e-01 0.388 0 0
Nuclear RNA decay R-HSA-9930044 3.888795e-01 0.410 0 0
Interleukin-15 signaling R-HSA-8983432 2.369905e-01 0.625 0 0
Oncogene Induced Senescence R-HSA-2559585 4.499270e-01 0.347 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.213894e-01 0.493 0 0
Signaling by WNT in cancer R-HSA-4791275 3.683693e-01 0.434 0 0
p75NTR signals via NF-kB R-HSA-193639 3.213894e-01 0.493 0 0
Signaling by FGFR2 R-HSA-5654738 3.213601e-01 0.493 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.206189e-01 0.494 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.584929e-01 0.446 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.727713e-01 0.429 0 0
Signaling by FGFR4 R-HSA-5654743 4.451777e-01 0.351 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.290097e-01 0.640 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.085345e-01 0.389 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.888795e-01 0.410 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.632520e-01 0.580 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.274349e-01 0.485 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.060101e-01 0.391 0 0
Apoptotic factor-mediated response R-HSA-111471 4.336064e-01 0.363 0 0
Signalling to ERKs R-HSA-187687 4.499270e-01 0.347 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.901174e-01 0.409 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.246726e-01 0.489 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.467480e-01 0.460 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.699857e-01 0.569 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.699857e-01 0.569 0 0
Mitochondrial transcription initiation R-HSA-163282 2.699857e-01 0.569 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.426911e-01 0.465 0 0
C6 deamination of adenosine R-HSA-75102 3.426911e-01 0.465 0 0
Regulation of PTEN localization R-HSA-8948747 2.822190e-01 0.549 0 0
Adenosine P1 receptors R-HSA-417973 4.081594e-01 0.389 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.497763e-01 0.456 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.632520e-01 0.580 0 0
Budding and maturation of HIV virion R-HSA-162588 3.478683e-01 0.459 0 0
Orc1 removal from chromatin R-HSA-68949 2.970919e-01 0.527 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.242423e-01 0.372 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.972000e-01 0.527 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.063297e-01 0.514 1 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.242423e-01 0.372 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.577107e-01 0.339 0 0
Co-stimulation by CD28 R-HSA-389356 2.385563e-01 0.622 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 2.918356e-01 0.535 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.577107e-01 0.339 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.918356e-01 0.535 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.426792e-01 0.615 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.856090e-01 0.414 0 0
Platelet degranulation R-HSA-114608 3.252655e-01 0.488 0 0
Protein methylation R-HSA-8876725 3.213894e-01 0.493 0 0
Mitophagy R-HSA-5205647 4.297091e-01 0.367 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.058098e-01 0.515 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.621251e-01 0.441 0 0
Netrin-1 signaling R-HSA-373752 3.066356e-01 0.513 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.044814e-01 0.393 0 0
Nef and signal transduction R-HSA-164944 2.436399e-01 0.613 0 0
CHL1 interactions R-HSA-447041 2.822190e-01 0.549 0 0
Protein hydroxylation R-HSA-9629569 2.687685e-01 0.571 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.349594e-01 0.475 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.861900e-01 0.413 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.044814e-01 0.393 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.471684e-01 0.459 0 0
Amine ligand-binding receptors R-HSA-375280 3.066356e-01 0.513 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.149421e-01 0.502 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.339845e-01 0.631 0 0
Signal transduction by L1 R-HSA-445144 2.687685e-01 0.571 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.085345e-01 0.389 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.060101e-01 0.391 0 0
Inhibition of membrane repair R-HSA-9635644 2.699857e-01 0.569 0 0
Transcription from mitochondrial promoters R-HSA-75944 3.426911e-01 0.465 0 0
Intracellular oxygen transport R-HSA-8981607 4.081594e-01 0.389 0 0
Josephin domain DUBs R-HSA-5689877 3.955650e-01 0.403 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.683693e-01 0.434 0 0
Platelet sensitization by LDL R-HSA-432142 4.336064e-01 0.363 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.192224e-01 0.496 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.252732e-01 0.488 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.089801e-01 0.388 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.089801e-01 0.388 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.592332e-01 0.445 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.592332e-01 0.445 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.592332e-01 0.445 0 0
Rap1 signalling R-HSA-392517 2.460499e-01 0.609 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.955650e-01 0.403 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.808460e-01 0.552 0 0
Suppression of apoptosis R-HSA-9635465 4.316195e-01 0.365 0 0
Myogenesis R-HSA-525793 4.321639e-01 0.364 0 0
RUNX2 regulates bone development R-HSA-8941326 2.986928e-01 0.525 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.162818e-01 0.500 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.274196e-01 0.485 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.699857e-01 0.569 0 0
CREB phosphorylation R-HSA-199920 2.436399e-01 0.613 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.822190e-01 0.549 0 0
Sodium/Proton exchangers R-HSA-425986 3.206189e-01 0.494 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.151486e-01 0.501 0 0
MAP kinase activation R-HSA-450294 4.366620e-01 0.360 0 0
Infectious disease R-HSA-5663205 2.387345e-01 0.622 0 0
Signaling by Hedgehog R-HSA-5358351 3.645401e-01 0.438 0 0
Formation of definitive endoderm R-HSA-9823730 2.687685e-01 0.571 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.021487e-01 0.396 0 0
Pyroptosis R-HSA-5620971 2.870172e-01 0.542 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 3.584912e-01 0.446 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.206189e-01 0.494 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.550922e-01 0.342 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.550922e-01 0.342 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.584929e-01 0.446 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.452938e-01 0.610 0 0
Long-term potentiation R-HSA-9620244 4.089801e-01 0.388 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.034556e-01 0.394 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.584929e-01 0.446 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.339845e-01 0.631 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.745394e-01 0.427 0 0
Selenoamino acid metabolism R-HSA-2408522 3.601377e-01 0.444 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.336064e-01 0.363 0 0
Regulation of signaling by CBL R-HSA-912631 4.607142e-01 0.337 0 0
Translesion Synthesis by POLH R-HSA-110320 4.607142e-01 0.337 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.607142e-01 0.337 0 0
Surfactant metabolism R-HSA-5683826 4.633311e-01 0.334 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.664913e-01 0.331 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.664913e-01 0.331 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.664913e-01 0.331 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 4.664913e-01 0.331 0 0
Integration of provirus R-HSA-162592 4.664913e-01 0.331 0 0
NF-kB is activated and signals survival R-HSA-209560 4.664913e-01 0.331 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.664913e-01 0.331 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.664913e-01 0.331 0 0
HCN channels R-HSA-1296061 4.671104e-01 0.331 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.671104e-01 0.331 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 4.671104e-01 0.331 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.671104e-01 0.331 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.671104e-01 0.331 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.671104e-01 0.331 0 0
Dopamine receptors R-HSA-390651 4.671104e-01 0.331 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.671104e-01 0.331 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.671104e-01 0.331 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.671104e-01 0.331 0 0
NADE modulates death signalling R-HSA-205025 4.671104e-01 0.331 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.671104e-01 0.331 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.677293e-01 0.330 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.699518e-01 0.328 0 0
RNA Polymerase III Transcription R-HSA-74158 4.699518e-01 0.328 0 0
PTEN Regulation R-HSA-6807070 4.701211e-01 0.328 0 0
Signaling by FGFR R-HSA-190236 4.724203e-01 0.326 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.741034e-01 0.324 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.777034e-01 0.321 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.777034e-01 0.321 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.777034e-01 0.321 0 0
Signaling by FGFR3 R-HSA-5654741 4.813274e-01 0.318 0 0
Immune System R-HSA-168256 4.831222e-01 0.316 1 0
Voltage gated Potassium channels R-HSA-1296072 4.897412e-01 0.310 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.897412e-01 0.310 0 0
Signaling by NOTCH4 R-HSA-9013694 4.909159e-01 0.309 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.910445e-01 0.309 0 0
Signaling by Erythropoietin R-HSA-9006335 4.999422e-01 0.301 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.999422e-01 0.301 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.999422e-01 0.301 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.000585e-01 0.301 0 0
Repression of WNT target genes R-HSA-4641265 5.000585e-01 0.301 0 0
MET activates RAS signaling R-HSA-8851805 5.000585e-01 0.301 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.000585e-01 0.301 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.000585e-01 0.301 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.000585e-01 0.301 0 0
Regulation of IFNG signaling R-HSA-877312 5.000585e-01 0.301 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.000585e-01 0.301 0 0
OAS antiviral response R-HSA-8983711 5.000585e-01 0.301 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.028895e-01 0.299 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.068982e-01 0.295 0 0
Signaling by FGFR1 R-HSA-5654736 5.068982e-01 0.295 0 0
Ion homeostasis R-HSA-5578775 5.068982e-01 0.295 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.131260e-01 0.290 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.131260e-01 0.290 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.131260e-01 0.290 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.131260e-01 0.290 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.201927e-01 0.284 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.201927e-01 0.284 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.201927e-01 0.284 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.201927e-01 0.284 0 0
Activation of AKT2 R-HSA-165158 5.201927e-01 0.284 0 0
Reelin signalling pathway R-HSA-8866376 5.201927e-01 0.284 0 0
Co-inhibition by BTLA R-HSA-9927353 5.201927e-01 0.284 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.201927e-01 0.284 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.201927e-01 0.284 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.201927e-01 0.284 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.202988e-01 0.284 1 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.284628e-01 0.277 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.284628e-01 0.277 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.284628e-01 0.277 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.322350e-01 0.274 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.322350e-01 0.274 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.322350e-01 0.274 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.322350e-01 0.274 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.322350e-01 0.274 0 0
Interleukin-6 signaling R-HSA-1059683 5.322350e-01 0.274 0 0
Maturation of nucleoprotein R-HSA-9683610 5.322350e-01 0.274 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.322350e-01 0.274 0 0
GPER1 signaling R-HSA-9634597 5.340738e-01 0.272 0 0
Gluconeogenesis R-HSA-70263 5.340738e-01 0.272 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.382939e-01 0.269 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.382939e-01 0.269 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.382939e-01 0.269 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.382939e-01 0.269 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 5.431120e-01 0.265 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.432706e-01 0.265 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.473281e-01 0.262 0 0
HIV Transcription Elongation R-HSA-167169 5.473281e-01 0.262 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.473281e-01 0.262 0 0
Attenuation phase R-HSA-3371568 5.473281e-01 0.262 0 0
Generation of second messenger molecules R-HSA-202433 5.473281e-01 0.262 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.495071e-01 0.260 0 0
Extension of Telomeres R-HSA-180786 5.546887e-01 0.256 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.579975e-01 0.253 0 0
Sensory processing of sound R-HSA-9659379 5.611199e-01 0.251 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.626990e-01 0.250 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.626990e-01 0.250 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.626990e-01 0.250 0 0
Signaling by KIT in disease R-HSA-9669938 5.626990e-01 0.250 0 0
LDL clearance R-HSA-8964038 5.626990e-01 0.250 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.626990e-01 0.250 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.629648e-01 0.250 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.629648e-01 0.250 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.629648e-01 0.250 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.629648e-01 0.250 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.629648e-01 0.250 0 0
G0 and Early G1 R-HSA-1538133 5.639628e-01 0.249 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.658241e-01 0.247 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.669160e-01 0.246 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.669160e-01 0.246 1 1
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.679901e-01 0.246 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.679901e-01 0.246 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.679901e-01 0.246 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.679901e-01 0.246 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.679901e-01 0.246 0 0
Phosphorylation of Emi1 R-HSA-176417 5.679901e-01 0.246 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.679901e-01 0.246 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 5.679901e-01 0.246 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 5.679901e-01 0.246 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.679901e-01 0.246 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.679901e-01 0.246 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.679901e-01 0.246 0 0
NGF-independant TRKA activation R-HSA-187024 5.679901e-01 0.246 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.679901e-01 0.246 0 0
Synthesis of PS R-HSA-1483101 5.679901e-01 0.246 0 0
PDE3B signalling R-HSA-165160 5.679901e-01 0.246 0 0
PKB-mediated events R-HSA-109703 5.679901e-01 0.246 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.679901e-01 0.246 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.679901e-01 0.246 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.724252e-01 0.242 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.724252e-01 0.242 0 0
Interleukin-17 signaling R-HSA-448424 5.724252e-01 0.242 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.834309e-01 0.234 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.839258e-01 0.234 0 0
HIV Transcription Initiation R-HSA-167161 5.839258e-01 0.234 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.839258e-01 0.234 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.842799e-01 0.233 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.842799e-01 0.233 0 0
G-protein beta:gamma signalling R-HSA-397795 5.842799e-01 0.233 0 0
HSF1-dependent transactivation R-HSA-3371571 5.844187e-01 0.233 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.863016e-01 0.232 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.863016e-01 0.232 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.863016e-01 0.232 0 0
Erythropoietin activates RAS R-HSA-9027284 5.922169e-01 0.228 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.922169e-01 0.228 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.922169e-01 0.228 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.922169e-01 0.228 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.922169e-01 0.228 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.922169e-01 0.228 0 0
Formation of the anterior neural plate R-HSA-9823739 5.922169e-01 0.228 0 0
Disease R-HSA-1643685 5.943487e-01 0.226 0 0
Neurexins and neuroligins R-HSA-6794361 6.005677e-01 0.221 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.005677e-01 0.221 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.040369e-01 0.219 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.040369e-01 0.219 1 1
Miscellaneous transport and binding events R-HSA-5223345 6.040369e-01 0.219 0 0
tRNA processing R-HSA-72306 6.044962e-01 0.219 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.090718e-01 0.215 0 0
Signaling by LTK in cancer R-HSA-9842640 6.110286e-01 0.214 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.110286e-01 0.214 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.110286e-01 0.214 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.110286e-01 0.214 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.110286e-01 0.214 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.110286e-01 0.214 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.110286e-01 0.214 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.110286e-01 0.214 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.110286e-01 0.214 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.110286e-01 0.214 0 0
Lipid particle organization R-HSA-8964572 6.110286e-01 0.214 0 0
Neurofascin interactions R-HSA-447043 6.110286e-01 0.214 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.188623e-01 0.208 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.188623e-01 0.208 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.188623e-01 0.208 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.199807e-01 0.208 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.199807e-01 0.208 0 0
Phosphorylation of the APC/C R-HSA-176412 6.199807e-01 0.208 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.199807e-01 0.208 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.199807e-01 0.208 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.199807e-01 0.208 0 0
Differentiation of T cells R-HSA-9945266 6.199807e-01 0.208 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.199807e-01 0.208 0 0
Dual Incision in GG-NER R-HSA-5696400 6.232122e-01 0.205 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.232122e-01 0.205 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.232122e-01 0.205 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.264068e-01 0.203 0 0
Signaling by FGFR in disease R-HSA-1226099 6.278450e-01 0.202 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.309884e-01 0.200 1 1
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.309884e-01 0.200 0 0
Cyclin D associated events in G1 R-HSA-69231 6.356625e-01 0.197 0 0
G1 Phase R-HSA-69236 6.356625e-01 0.197 0 0
DAP12 interactions R-HSA-2172127 6.356625e-01 0.197 0 0
PI Metabolism R-HSA-1483255 6.377947e-01 0.195 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.394725e-01 0.194 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.410718e-01 0.193 0 0
PERK regulates gene expression R-HSA-381042 6.417887e-01 0.193 0 0
Phase 2 - plateau phase R-HSA-5576893 6.462623e-01 0.190 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.462623e-01 0.190 0 0
Passive transport by Aquaporins R-HSA-432047 6.462623e-01 0.190 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.462623e-01 0.190 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.462623e-01 0.190 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.462623e-01 0.190 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.462623e-01 0.190 0 0
Synthesis of PG R-HSA-1483148 6.462623e-01 0.190 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.462623e-01 0.190 0 0
Neuronal System R-HSA-112316 6.467984e-01 0.189 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.474775e-01 0.189 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.497817e-01 0.187 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.497817e-01 0.187 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.497817e-01 0.187 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.497817e-01 0.187 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.497817e-01 0.187 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.497817e-01 0.187 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.497817e-01 0.187 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.497817e-01 0.187 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.497817e-01 0.187 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.497817e-01 0.187 0 0
Disinhibition of SNARE formation R-HSA-114516 6.497817e-01 0.187 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.497817e-01 0.187 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.497817e-01 0.187 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.497817e-01 0.187 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.497817e-01 0.187 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.497817e-01 0.187 0 0
VLDL clearance R-HSA-8964046 6.497817e-01 0.187 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.497817e-01 0.187 0 0
Activation of TRKA receptors R-HSA-187015 6.497817e-01 0.187 0 0
Netrin mediated repulsion signals R-HSA-418886 6.497817e-01 0.187 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.497817e-01 0.187 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.497817e-01 0.187 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.517592e-01 0.186 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.519991e-01 0.186 0 0
MET activates PTK2 signaling R-HSA-8874081 6.520379e-01 0.186 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.520379e-01 0.186 0 0
Transmission across Chemical Synapses R-HSA-112315 6.535157e-01 0.185 0 0
SLC transporter disorders R-HSA-5619102 6.568995e-01 0.183 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.597537e-01 0.181 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.597537e-01 0.181 0 0
GPVI-mediated activation cascade R-HSA-114604 6.597537e-01 0.181 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.597537e-01 0.181 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.678617e-01 0.175 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.710815e-01 0.173 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.722137e-01 0.172 0 0
Parasite infection R-HSA-9664407 6.756682e-01 0.170 0 0
Leishmania phagocytosis R-HSA-9664417 6.756682e-01 0.170 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.756682e-01 0.170 0 0
Adipogenesis R-HSA-9843745 6.766263e-01 0.170 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.770984e-01 0.169 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.832424e-01 0.165 0 0
Potential therapeutics for SARS R-HSA-9679191 6.837942e-01 0.165 0 0
Potassium Channels R-HSA-1296071 6.839571e-01 0.165 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.846759e-01 0.165 0 0
DAG1 core M2 glycosylations R-HSA-8932504 6.846759e-01 0.165 0 0
phospho-PLA2 pathway R-HSA-111995 6.846759e-01 0.165 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.846759e-01 0.165 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.846759e-01 0.165 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.846759e-01 0.165 0 0
Interleukin-23 signaling R-HSA-9020933 6.846759e-01 0.165 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.846759e-01 0.165 0 0
Fructose biosynthesis R-HSA-5652227 6.846759e-01 0.165 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.846759e-01 0.165 0 0
Interleukin-9 signaling R-HSA-8985947 6.846759e-01 0.165 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.846759e-01 0.165 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.846759e-01 0.165 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.847790e-01 0.164 0 0
Dual incision in TC-NER R-HSA-6782135 6.898077e-01 0.161 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.898077e-01 0.161 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.912154e-01 0.160 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.915153e-01 0.160 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.915153e-01 0.160 0 0
Neutrophil degranulation R-HSA-6798695 6.931468e-01 0.159 1 1
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.938175e-01 0.159 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.944688e-01 0.158 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.944688e-01 0.158 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.944688e-01 0.158 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.944688e-01 0.158 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 6.944688e-01 0.158 0 0
Toll-like Receptor Cascades R-HSA-168898 6.973625e-01 0.157 0 0
Interleukin-1 family signaling R-HSA-446652 7.010833e-01 0.154 0 0
Translation R-HSA-72766 7.018323e-01 0.154 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.033192e-01 0.153 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.099476e-01 0.149 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.099476e-01 0.149 0 0
mRNA Capping R-HSA-72086 7.099476e-01 0.149 0 0
Platelet calcium homeostasis R-HSA-418360 7.099476e-01 0.149 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.099476e-01 0.149 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.160953e-01 0.145 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.160953e-01 0.145 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.160953e-01 0.145 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.160953e-01 0.145 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.160953e-01 0.145 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.160953e-01 0.145 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.160953e-01 0.145 0 0
mRNA Editing R-HSA-75072 7.160953e-01 0.145 0 0
ARMS-mediated activation R-HSA-170984 7.160953e-01 0.145 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.160953e-01 0.145 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.160953e-01 0.145 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.160953e-01 0.145 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.160953e-01 0.145 0 0
Interleukin-1 processing R-HSA-448706 7.160953e-01 0.145 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.164630e-01 0.145 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.164630e-01 0.145 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.164630e-01 0.145 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.164630e-01 0.145 0 0
Other interleukin signaling R-HSA-449836 7.164630e-01 0.145 0 0
Maturation of nucleoprotein R-HSA-9694631 7.164630e-01 0.145 0 0
The NLRP3 inflammasome R-HSA-844456 7.164630e-01 0.145 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.253741e-01 0.139 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.253741e-01 0.139 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.253741e-01 0.139 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.253741e-01 0.139 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.253741e-01 0.139 0 0
Diseases of Immune System R-HSA-5260271 7.253741e-01 0.139 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.264490e-01 0.139 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.275201e-01 0.138 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.275201e-01 0.138 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.275201e-01 0.138 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.275201e-01 0.138 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.291297e-01 0.137 0 0
TCR signaling R-HSA-202403 7.313675e-01 0.136 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.371096e-01 0.132 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.371096e-01 0.132 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.371096e-01 0.132 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.371096e-01 0.132 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.371096e-01 0.132 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.371096e-01 0.132 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.371096e-01 0.132 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.442461e-01 0.128 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.443857e-01 0.128 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.443857e-01 0.128 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.443857e-01 0.128 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.443857e-01 0.128 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.443857e-01 0.128 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.443857e-01 0.128 0 0
Pexophagy R-HSA-9664873 7.443857e-01 0.128 0 0
Interleukin-27 signaling R-HSA-9020956 7.443857e-01 0.128 0 0
Sperm Motility And Taxes R-HSA-1300642 7.443857e-01 0.128 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.443857e-01 0.128 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.443857e-01 0.128 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.443857e-01 0.128 0 0
Serotonin receptors R-HSA-390666 7.443857e-01 0.128 0 0
Formation of apoptosome R-HSA-111458 7.443857e-01 0.128 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.533169e-01 0.123 0 0
Intra-Golgi traffic R-HSA-6811438 7.544419e-01 0.122 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.564587e-01 0.121 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.564587e-01 0.121 0 0
Opioid Signalling R-HSA-111885 7.639295e-01 0.117 1 0
Ion transport by P-type ATPases R-HSA-936837 7.648039e-01 0.116 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.652409e-01 0.116 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.657782e-01 0.116 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.698585e-01 0.114 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.698585e-01 0.114 0 0
LGI-ADAM interactions R-HSA-5682910 7.698585e-01 0.114 0 0
vRNA Synthesis R-HSA-192814 7.698585e-01 0.114 0 0
Conjugation of benzoate with glycine R-HSA-177135 7.698585e-01 0.114 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.698585e-01 0.114 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.698585e-01 0.114 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.698585e-01 0.114 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.698585e-01 0.114 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.698585e-01 0.114 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.698585e-01 0.114 0 0
Transport of RCbl within the body R-HSA-9758890 7.698585e-01 0.114 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.698585e-01 0.114 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.745637e-01 0.111 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.745637e-01 0.111 0 0
Attachment and Entry R-HSA-9694614 7.745637e-01 0.111 0 0
Ribavirin ADME R-HSA-9755088 7.745637e-01 0.111 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.745637e-01 0.111 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.752288e-01 0.111 0 0
Cardiogenesis R-HSA-9733709 7.752288e-01 0.111 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.772039e-01 0.109 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.861282e-01 0.105 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.886925e-01 0.103 0 0
Signaling by NOTCH3 R-HSA-9012852 7.886925e-01 0.103 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.895269e-01 0.103 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.914804e-01 0.102 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.914804e-01 0.102 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.914804e-01 0.102 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.927942e-01 0.101 0 0
ERKs are inactivated R-HSA-202670 7.927942e-01 0.101 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.927942e-01 0.101 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.927942e-01 0.101 0 0
Integrin cell surface interactions R-HSA-216083 7.957940e-01 0.099 0 0
PCP/CE pathway R-HSA-4086400 7.957940e-01 0.099 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.997142e-01 0.097 0 0
TNF signaling R-HSA-75893 7.997142e-01 0.097 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.030604e-01 0.095 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.030604e-01 0.095 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.053656e-01 0.094 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.072659e-01 0.093 0 0
Biosynthesis of maresins R-HSA-9018682 8.072659e-01 0.093 0 0
Carnitine shuttle R-HSA-200425 8.072659e-01 0.093 0 0
Formation of the ureteric bud R-HSA-9830674 8.072659e-01 0.093 0 0
Integration of energy metabolism R-HSA-163685 8.112794e-01 0.091 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.134453e-01 0.090 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.134453e-01 0.090 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.134453e-01 0.090 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.134453e-01 0.090 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.134453e-01 0.090 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.134453e-01 0.090 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.134453e-01 0.090 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.134453e-01 0.090 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.134453e-01 0.090 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.134453e-01 0.090 0 0
Interleukin-35 Signalling R-HSA-8984722 8.134453e-01 0.090 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.141259e-01 0.089 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.158547e-01 0.088 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.158547e-01 0.088 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.166629e-01 0.088 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.203915e-01 0.086 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.219774e-01 0.085 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.219774e-01 0.085 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.219774e-01 0.085 0 0
Interleukin-6 family signaling R-HSA-6783589 8.219774e-01 0.085 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.274154e-01 0.082 0 0
FLT3 signaling in disease R-HSA-9682385 8.279359e-01 0.082 0 0
Interleukin-1 signaling R-HSA-9020702 8.286429e-01 0.082 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.298883e-01 0.081 0 0
Regulation of beta-cell development R-HSA-186712 8.300664e-01 0.081 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.320394e-01 0.080 0 0
Formation of axial mesoderm R-HSA-9796292 8.320394e-01 0.080 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.320394e-01 0.080 0 0
Frs2-mediated activation R-HSA-170968 8.320394e-01 0.080 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.320394e-01 0.080 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.320394e-01 0.080 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.320394e-01 0.080 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.320394e-01 0.080 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.320394e-01 0.080 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.320394e-01 0.080 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.342515e-01 0.079 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.342515e-01 0.079 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.356723e-01 0.078 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.356723e-01 0.078 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.356723e-01 0.078 0 0
Laminin interactions R-HSA-3000157 8.356723e-01 0.078 0 0
Hyaluronan degradation R-HSA-2160916 8.356723e-01 0.078 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.393311e-01 0.076 0 0
Degradation of DVL R-HSA-4641258 8.393311e-01 0.076 0 0
Cardiac conduction R-HSA-5576891 8.426524e-01 0.074 0 0
Degradation of CDH1 R-HSA-9766229 8.473500e-01 0.072 0 0
PLC beta mediated events R-HSA-112043 8.481416e-01 0.072 1 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.481416e-01 0.072 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.484069e-01 0.071 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.484069e-01 0.071 0 0
TRP channels R-HSA-3295583 8.484069e-01 0.071 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.484069e-01 0.071 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.484069e-01 0.071 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.484069e-01 0.071 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.484069e-01 0.071 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.487812e-01 0.071 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.487812e-01 0.071 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.487812e-01 0.071 0 0
Hydrolysis of LPC R-HSA-1483115 8.487812e-01 0.071 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.487812e-01 0.071 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 8.487812e-01 0.071 0 0
cGMP effects R-HSA-418457 8.487812e-01 0.071 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 8.487812e-01 0.071 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 8.487812e-01 0.071 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.487812e-01 0.071 0 0
Prolactin receptor signaling R-HSA-1170546 8.487812e-01 0.071 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.487812e-01 0.071 0 0
HDL assembly R-HSA-8963896 8.487812e-01 0.071 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.487812e-01 0.071 0 0
P2Y receptors R-HSA-417957 8.487812e-01 0.071 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.487812e-01 0.071 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.499490e-01 0.071 0 0
RSV-host interactions R-HSA-9833110 8.565400e-01 0.067 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.565647e-01 0.067 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.565647e-01 0.067 0 0
PI3K Cascade R-HSA-109704 8.565656e-01 0.067 0 0
Azathioprine ADME R-HSA-9748787 8.565656e-01 0.067 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.601738e-01 0.065 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.601738e-01 0.065 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.602366e-01 0.065 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.602366e-01 0.065 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.602366e-01 0.065 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 8.602366e-01 0.065 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.638550e-01 0.064 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.638550e-01 0.064 0 0
Translesion synthesis by REV1 R-HSA-110312 8.638550e-01 0.064 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.638550e-01 0.064 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.638550e-01 0.064 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 8.638550e-01 0.064 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.638550e-01 0.064 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.638550e-01 0.064 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.638550e-01 0.064 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.638550e-01 0.064 0 0
Other semaphorin interactions R-HSA-416700 8.638550e-01 0.064 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.645940e-01 0.063 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.696768e-01 0.061 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.712152e-01 0.060 0 0
Telomere Extension By Telomerase R-HSA-171319 8.712152e-01 0.060 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.712152e-01 0.060 0 0
Inflammasomes R-HSA-622312 8.712152e-01 0.060 0 0
Insulin receptor signalling cascade R-HSA-74751 8.722416e-01 0.059 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.722416e-01 0.059 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.735796e-01 0.059 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.735796e-01 0.059 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.759617e-01 0.058 0 0
Translesion synthesis by POLI R-HSA-5656121 8.774271e-01 0.057 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.774271e-01 0.057 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.774271e-01 0.057 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.774271e-01 0.057 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.774271e-01 0.057 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.774271e-01 0.057 0 0
Prolonged ERK activation events R-HSA-169893 8.774271e-01 0.057 0 0
Atorvastatin ADME R-HSA-9754706 8.774271e-01 0.057 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.774271e-01 0.057 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.774271e-01 0.057 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.774271e-01 0.057 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.774271e-01 0.057 0 0
Attachment and Entry R-HSA-9678110 8.774271e-01 0.057 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.786045e-01 0.056 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.786045e-01 0.056 0 0
Cellular response to hypoxia R-HSA-1234174 8.795200e-01 0.056 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.813948e-01 0.055 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.813948e-01 0.055 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.814131e-01 0.055 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.814131e-01 0.055 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.861840e-01 0.052 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.869844e-01 0.052 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.869844e-01 0.052 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.896470e-01 0.051 0 0
Translesion synthesis by POLK R-HSA-5655862 8.896470e-01 0.051 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.896470e-01 0.051 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.896470e-01 0.051 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.896470e-01 0.051 0 0
Fibronectin matrix formation R-HSA-1566977 8.896470e-01 0.051 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.896470e-01 0.051 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.896470e-01 0.051 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 8.896470e-01 0.051 0 0
Galactose catabolism R-HSA-70370 8.896470e-01 0.051 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.896470e-01 0.051 0 0
Gastrulation R-HSA-9758941 8.902832e-01 0.050 0 0
G-protein mediated events R-HSA-112040 8.930192e-01 0.049 1 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.937280e-01 0.049 1 0
Ca-dependent events R-HSA-111996 8.948431e-01 0.048 1 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.995555e-01 0.046 0 0
Trafficking of AMPA receptors R-HSA-399719 8.995555e-01 0.046 0 0
Cargo concentration in the ER R-HSA-5694530 8.995555e-01 0.046 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.995555e-01 0.046 0 0
Downstream signal transduction R-HSA-186763 8.995555e-01 0.046 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.995555e-01 0.046 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.006492e-01 0.045 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.006492e-01 0.045 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.006492e-01 0.045 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.006492e-01 0.045 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.006492e-01 0.045 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.006492e-01 0.045 0 0
Catecholamine biosynthesis R-HSA-209905 9.006492e-01 0.045 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.006492e-01 0.045 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.006492e-01 0.045 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.048705e-01 0.043 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.076307e-01 0.042 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.079216e-01 0.042 0 0
IRS-mediated signalling R-HSA-112399 9.086664e-01 0.042 0 0
Synthesis of PA R-HSA-1483166 9.086664e-01 0.042 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.091022e-01 0.041 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.105551e-01 0.041 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 9.105551e-01 0.041 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.105551e-01 0.041 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.105551e-01 0.041 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.105551e-01 0.041 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.105551e-01 0.041 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.105551e-01 0.041 0 0
Tie2 Signaling R-HSA-210993 9.105551e-01 0.041 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.108122e-01 0.041 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.136272e-01 0.039 0 0
PPARA activates gene expression R-HSA-1989781 9.147128e-01 0.039 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.150948e-01 0.039 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.150948e-01 0.039 0 0
Recycling of bile acids and salts R-HSA-159418 9.150948e-01 0.039 0 0
DAG and IP3 signaling R-HSA-1489509 9.155531e-01 0.038 1 1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.155531e-01 0.038 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.155531e-01 0.038 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.182165e-01 0.037 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.194738e-01 0.036 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.194738e-01 0.036 0 0
Conjugation of carboxylic acids R-HSA-159424 9.194738e-01 0.036 0 0
Amino Acid conjugation R-HSA-156587 9.194738e-01 0.036 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.194738e-01 0.036 0 0
Specification of the neural plate border R-HSA-9834899 9.194738e-01 0.036 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.194738e-01 0.036 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.194738e-01 0.036 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.194738e-01 0.036 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.200844e-01 0.036 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.200844e-01 0.036 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.215841e-01 0.035 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.219894e-01 0.035 0 0
Heme degradation R-HSA-189483 9.219894e-01 0.035 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.225932e-01 0.035 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.251812e-01 0.034 0 0
RAB geranylgeranylation R-HSA-8873719 9.252992e-01 0.034 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.252992e-01 0.034 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.272186e-01 0.033 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.275037e-01 0.033 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.275037e-01 0.033 0 0
Signaling by NODAL R-HSA-1181150 9.275037e-01 0.033 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.275037e-01 0.033 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.275037e-01 0.033 0 0
Pregnenolone biosynthesis R-HSA-196108 9.275037e-01 0.033 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.275165e-01 0.033 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.279801e-01 0.032 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.283538e-01 0.032 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.283538e-01 0.032 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.283538e-01 0.032 0 0
Hyaluronan metabolism R-HSA-2142845 9.283538e-01 0.032 0 0
Signal amplification R-HSA-392518 9.283538e-01 0.032 0 0
Signaling by NOTCH2 R-HSA-1980145 9.283538e-01 0.032 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.304693e-01 0.031 0 0
G alpha (s) signalling events R-HSA-418555 9.330492e-01 0.030 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.338728e-01 0.030 0 0
Stimuli-sensing channels R-HSA-2672351 9.338728e-01 0.030 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.342252e-01 0.030 0 0
Regulation of Apoptosis R-HSA-169911 9.342252e-01 0.030 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.347333e-01 0.029 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.347333e-01 0.029 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.347333e-01 0.029 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.347333e-01 0.029 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.347333e-01 0.029 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.347333e-01 0.029 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.373871e-01 0.028 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.373871e-01 0.028 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.373871e-01 0.028 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.373871e-01 0.028 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.396385e-01 0.027 0 0
Calmodulin induced events R-HSA-111933 9.396385e-01 0.027 1 1
CaM pathway R-HSA-111997 9.396385e-01 0.027 1 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.396385e-01 0.027 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.396385e-01 0.027 0 0
Assembly Of The HIV Virion R-HSA-175474 9.412423e-01 0.026 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.419635e-01 0.026 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.423867e-01 0.026 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.446268e-01 0.025 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.462279e-01 0.024 0 0
Complex IV assembly R-HSA-9864848 9.462279e-01 0.024 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.471026e-01 0.024 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.471026e-01 0.024 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.471026e-01 0.024 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.471026e-01 0.024 0 0
Fructose metabolism R-HSA-5652084 9.471026e-01 0.024 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.471026e-01 0.024 0 0
Elastic fibre formation R-HSA-1566948 9.492208e-01 0.023 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.501993e-01 0.022 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.523786e-01 0.021 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.523786e-01 0.021 0 0
Interleukin-20 family signaling R-HSA-8854691 9.523786e-01 0.021 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.523786e-01 0.021 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.523786e-01 0.021 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.523786e-01 0.021 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.523786e-01 0.021 0 0
Stabilization of p53 R-HSA-69541 9.534497e-01 0.021 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.534497e-01 0.021 0 0
Pentose phosphate pathway R-HSA-71336 9.534497e-01 0.021 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.536073e-01 0.021 0 0
Nucleotide biosynthesis R-HSA-8956320 9.538957e-01 0.020 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.539887e-01 0.020 0 0
Parasitic Infection Pathways R-HSA-9824443 9.541630e-01 0.020 0 0
Leishmania infection R-HSA-9658195 9.541630e-01 0.020 0 0
Signaling by Insulin receptor R-HSA-74752 9.556152e-01 0.020 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.562651e-01 0.019 0 0
CYP2E1 reactions R-HSA-211999 9.571287e-01 0.019 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.571287e-01 0.019 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.571287e-01 0.019 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.571287e-01 0.019 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.573405e-01 0.019 0 0
Interferon gamma signaling R-HSA-877300 9.583441e-01 0.018 1 1
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.597616e-01 0.018 0 0
G alpha (z) signalling events R-HSA-418597 9.605313e-01 0.017 1 1
Paracetamol ADME R-HSA-9753281 9.605313e-01 0.017 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.609186e-01 0.017 0 0
Maturation of spike protein R-HSA-9694548 9.609186e-01 0.017 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.614053e-01 0.017 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.614053e-01 0.017 0 0
G protein gated Potassium channels R-HSA-1296059 9.614053e-01 0.017 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.614053e-01 0.017 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.614053e-01 0.017 0 0
Fertilization R-HSA-1187000 9.614053e-01 0.017 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.614053e-01 0.017 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.628433e-01 0.016 0 0
Platelet homeostasis R-HSA-418346 9.634099e-01 0.016 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.642077e-01 0.016 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.642077e-01 0.016 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.642077e-01 0.016 0 0
Translation of Structural Proteins R-HSA-9683701 9.642077e-01 0.016 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.652555e-01 0.015 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.652555e-01 0.015 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.652555e-01 0.015 0 0
Hedgehog 'on' state R-HSA-5632684 9.654243e-01 0.015 0 0
Dectin-2 family R-HSA-5621480 9.662615e-01 0.015 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.672297e-01 0.014 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.687217e-01 0.014 0 0
Cristae formation R-HSA-8949613 9.687217e-01 0.014 0 0
Signaling by BMP R-HSA-201451 9.687217e-01 0.014 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.687217e-01 0.014 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.687217e-01 0.014 0 0
Triglyceride biosynthesis R-HSA-75109 9.687217e-01 0.014 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.700052e-01 0.013 0 0
Ca2+ pathway R-HSA-4086398 9.700931e-01 0.013 0 0
Ion channel transport R-HSA-983712 9.705774e-01 0.013 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.714930e-01 0.013 0 0
Regulation of insulin secretion R-HSA-422356 9.714930e-01 0.013 0 0
Insulin receptor recycling R-HSA-77387 9.718424e-01 0.012 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.718424e-01 0.012 0 0
Prednisone ADME R-HSA-9757110 9.718424e-01 0.012 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.725533e-01 0.012 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.746109e-01 0.011 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.746519e-01 0.011 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.748917e-01 0.011 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.748917e-01 0.011 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.748917e-01 0.011 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.748917e-01 0.011 0 0
ABC-family proteins mediated transport R-HSA-382556 9.749561e-01 0.011 0 0
Aquaporin-mediated transport R-HSA-445717 9.754483e-01 0.011 0 0
ER-Phagosome pathway R-HSA-1236974 9.759086e-01 0.011 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.770370e-01 0.010 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.770370e-01 0.010 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.770370e-01 0.010 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.771812e-01 0.010 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.771812e-01 0.010 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.771812e-01 0.010 0 0
Neurotransmitter clearance R-HSA-112311 9.771812e-01 0.010 0 0
Mitochondrial protein import R-HSA-1268020 9.773422e-01 0.010 0 0
Signaling by PDGF R-HSA-186797 9.773422e-01 0.010 0 0
Neurotransmitter release cycle R-HSA-112310 9.775204e-01 0.010 0 0
Translation of Structural Proteins R-HSA-9694635 9.777162e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.790042e-01 0.009 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.808021e-01 0.008 0 0
Metal ion SLC transporters R-HSA-425410 9.808077e-01 0.008 0 0
DAG1 glycosylations R-HSA-8931838 9.815082e-01 0.008 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.815082e-01 0.008 0 0
HS-GAG degradation R-HSA-2024096 9.815082e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.841734e-01 0.007 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.850151e-01 0.007 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.850151e-01 0.007 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.853614e-01 0.006 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.853614e-01 0.006 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.865108e-01 0.006 0 0
eNOS activation R-HSA-203615 9.865108e-01 0.006 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.865108e-01 0.006 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.865108e-01 0.006 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.866311e-01 0.006 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.877932e-01 0.005 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.878572e-01 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.878572e-01 0.005 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.878572e-01 0.005 0 0
COPII-mediated vesicle transport R-HSA-204005 9.882045e-01 0.005 0 0
HS-GAG biosynthesis R-HSA-2022928 9.890694e-01 0.005 0 0
Glycosphingolipid transport R-HSA-9845576 9.890694e-01 0.005 0 0
Triglyceride catabolism R-HSA-163560 9.890694e-01 0.005 0 0
ECM proteoglycans R-HSA-3000178 9.891420e-01 0.005 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.895492e-01 0.005 0 0
Formation of the cornified envelope R-HSA-6809371 9.896209e-01 0.005 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.900076e-01 0.004 0 0
Degradation of AXIN R-HSA-4641257 9.901606e-01 0.004 0 0
NCAM1 interactions R-HSA-419037 9.901606e-01 0.004 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.901606e-01 0.004 0 0
Collagen chain trimerization R-HSA-8948216 9.901606e-01 0.004 0 0
Phospholipid metabolism R-HSA-1483257 9.902797e-01 0.004 0 0
Aspirin ADME R-HSA-9749641 9.908065e-01 0.004 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.911429e-01 0.004 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.911429e-01 0.004 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.911429e-01 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.914877e-01 0.004 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.920272e-01 0.003 0 0
Post-translational protein modification R-HSA-597592 9.921862e-01 0.003 0 0
Downstream TCR signaling R-HSA-202424 9.923396e-01 0.003 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.925982e-01 0.003 1 1
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.928233e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.928233e-01 0.003 0 0
Peroxisomal protein import R-HSA-9033241 9.929561e-01 0.003 0 0
Triglyceride metabolism R-HSA-8979227 9.929561e-01 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.935399e-01 0.003 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.935399e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.935770e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.939475e-01 0.003 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.939475e-01 0.003 0 0
Interleukin-10 signaling R-HSA-6783783 9.939604e-01 0.003 0 0
Endogenous sterols R-HSA-211976 9.941443e-01 0.003 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.941443e-01 0.003 0 0
Extracellular matrix organization R-HSA-1474244 9.944485e-01 0.002 0 0
Activation of GABAB receptors R-HSA-991365 9.947657e-01 0.002 0 0
GABA B receptor activation R-HSA-977444 9.947657e-01 0.002 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.947657e-01 0.002 0 0
Pyrimidine catabolism R-HSA-73621 9.952885e-01 0.002 0 0
Xenobiotics R-HSA-211981 9.955671e-01 0.002 0 0
Proteasome assembly R-HSA-9907900 9.957590e-01 0.002 0 0
Methylation R-HSA-156581 9.957590e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.957590e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.961826e-01 0.002 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.961826e-01 0.002 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.961826e-01 0.002 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.961826e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.961826e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.961826e-01 0.002 0 0
Kidney development R-HSA-9830369 9.966490e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.966490e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.969483e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.974347e-01 0.001 0 0
Neddylation R-HSA-8951664 9.974490e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.974702e-01 0.001 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.974702e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.975232e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.976971e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.976971e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.977446e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.978441e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.979700e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.984458e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.985530e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.986068e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.987240e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.988009e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.988115e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.988115e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.988736e-01 0.000 1 0
Protein localization R-HSA-9609507 9.989562e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.990206e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.990314e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.990421e-01 0.000 1 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.991065e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.991257e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.992131e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.992131e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.992131e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.992131e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.992493e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.992918e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.993685e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.994837e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.995844e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.996236e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.996236e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.996366e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996613e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.997154e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997441e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997531e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997531e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997828e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997828e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998000e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998200e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.998234e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998304e-01 0.000 1 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998380e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998380e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998820e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999140e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.999303e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999357e-01 0.000 1 0
Sulfur amino acid metabolism R-HSA-1614635 9.999543e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999668e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999700e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999765e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999787e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999791e-01 0.000 1 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999841e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999850e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999871e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999896e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999916e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999939e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999941e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999951e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999970e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999971e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999977e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999985e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999987e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999990e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999992e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999992e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999996e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways