MEKK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O00165	S153	Sugiyama	HAX1 HS1BP1	PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O15047	S470	Sugiyama	SETD1A KIAA0339 KMT2F SET1 SET1A	sPEREEVRtsPRPAsPARsGsPAPEttNESVPFAQHSSLDS
O43707	T443	Sugiyama	ACTN4	sIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDL
O43852	T89	Sugiyama	CALU	sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O95757	T82	Sugiyama	HSPA4L APG1 HSPH3 OSP94	NTIHGFKKLHGRsFDDPIVQtERIRLPYELQKMPNGSAGVK
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00558	T168	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	T168	Sugiyama	PGK2 PGKB	EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09972	T125	Sugiyama	ALDOC ALDC	VGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGADF
P0DPH7	T334	Sugiyama	TUBA3C TUBA2	ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P12270	T1518	Sugiyama	TPR	ENLQKTLSEKETEARNLQEQtVQLQSELSRLRQDLQDRTTQ
P12814	T424	Sugiyama	ACTN1	sIHEAWtDGKEAMLRQKDyEtAtLsEIKALLKKHEAFEsDL
P13489	T176	Sugiyama	RNH1 PRI RNH	AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD
P13987	T76	Sugiyama	CD59 MIC11 MIN1 MIN2 MIN3 MSK21	AGLQVYNKCWKFEHCNFNDVtTRLRENELtyyCCKKDLCNF
P15170	T315	Sugiyama	GSPT1 ERF3A	NRSVDGPIRLPIVDKYKDMGtVVLGKLESGSICKGQQLVMM
P16070	T76	Sugiyama	CD44 LHR MDU2 MDU3 MIC4	FNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRIHPNSI
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30086	S60	Sugiyama	PEBP1 PBP PEBP	VLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPK
P30101	T485	Sugiyama	PDIA3 ERP57 ERP60 GRP58	KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31949	T33	Sugiyama	S100A11 MLN70 S100C	CIESLIAVFQKYAGKDGyNytLsKtEFLsFMNTELAAFTKN
P35222	S675	EPSD\|PSP	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	AAAVLFRMSEDKPQDyKKRLsVELtssLFRTEPMAWNETAD
P35269	T389	Sugiyama	GTF2F1 RAP74	PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38117	T172	Sugiyama	ETFB FP585	QVTLEGDKLKVEREIDGGLEtLRLKLPAVVTADLRLNEPRy
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P45985	S257	GPS6	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	LDRSGNIKLCDFGIsGQLVDsIAKtRDAGCRPyMAPERIDP
P45985	T261	GPS6	MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1	GNIKLCDFGIsGQLVDsIAKtRDAGCRPyMAPERIDPSASR
P47712	S724	Sugiyama	PLA2G4A CPLA2 PLA2G4	NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P47712	S729	Sugiyama	PLA2G4A CPLA2 PLA2G4	KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P50395	T408	Sugiyama	GDI2 RABGDIB	VPKDLGtEsQIFIsRTyDAttHFEttCDDIKNIYKRMtGsE
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P60174	T90	Sugiyama	TPI1 TPI	VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60660	T103	Sugiyama	MYL6	QGtyEDyVEGLRVFDKEGNGtVMGAEIRHVLVtLGEKMTEE
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62424	T84	Sugiyama	RPL7A SURF-3 SURF3	QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62826	T21	Sugiyama	RAN ARA24 OK/SW-cl.81	MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63167	T26	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220	S68	Sugiyama	RPS21	GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363	T334	Sugiyama	TUBA1B	ACCLLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVG
P68363	T80	Sugiyama	TUBA1B	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363	Y432	Sugiyama	TUBA1B	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78371	T246	Sugiyama	CCT2 99D8.1 CCTB	VNQPKRIENAKILIANtGMDtDKIKIFGsRVRVDstAKVAE
P85037	S420	Sugiyama	FOXK1 MNF	RGVSCFRtPFGPLssRsAPAsPtHPGLMsPRsGGLQtPECL
P85037	S428	Sugiyama	FOXK1 MNF	PFGPLssRsAPAsPtHPGLMsPRsGGLQtPECLsREGsPIP
Q02750	S218	ELM	MAP2K1 MEK1 PRKMK1	VNSRGEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGT
Q02750	S222	ELM	MAP2K1 MEK1 PRKMK1	GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283	T241	Sugiyama	G3BP1 G3BP	ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14247	T328	Sugiyama	CTTN EMS1	GKyGVQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKts
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14653	S173	EPSD\|PSP	IRF3	PDPGPPSLAVAPEPCPQPLRsPsLDNPtPFPNLGPsENPLK
Q15208	S91	PSP	STK38 NDR1	RKEtEFLRLKRTRLGLEDFEsLKVIGRGAFGEVRLVQKKDT
Q15293	T100	Sugiyama	RCN1 RCN	sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV
Q15427	T14	Sugiyama	SF3B4 SAP49	_______MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFL
Q27J81	T1206	Sugiyama	INF2 C14orf151 C14orf173	DtsLDKsFsEDAVtDssGsGtLPRARGRASKGTGKRRKKRP
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q53EL6	S94	Sugiyama	PDCD4 H731	GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q6PEY2	T334	Sugiyama	TUBA3E	ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15	T494	Sugiyama	FIP1L1 FIP1 RHE	DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q71U36	T334	Sugiyama	TUBA1A TUBA3	ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q71U36	T80	Sugiyama	TUBA1A TUBA3	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36	Y432	Sugiyama	TUBA1A TUBA3	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7Z2W4	T294	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	PsPDQIsHRAsLEDAPVDDLtRKFtyLGsQDRARPPsGsSK
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IWW6	S240	Sugiyama	ARHGAP12	SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6	T231	Sugiyama	ARHGAP12	QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IYD1	T444	Sugiyama	GSPT2 ERF3B	NRSIDGPIRLPIVDKYKDMGtVVLGKLESGSIFKGQQLVMM
Q8IZ21	S118	Sugiyama	PHACTR4 PRO2963	PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N3A8	T355	Sugiyama	PARP8	KSHRTFGRsLSSDPRAEQAMtAIKSHKLLNRPCPAAVKsEE
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q96AE4	S52	Sugiyama	FUBP1	KDALQRARQIAAKIGGDAGtsLNsNDyGyGGQKRPLEDGDQ
Q96MH2	S76	Sugiyama	HEXIM2 L3	EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96S44	T8	Sugiyama	TP53RK C20orf64 PRPK	_____________MAAARAttPADGEEPAPEAEALAAARER
Q99627	T158	Sugiyama	COPS8 CSN8	GLPVEEAVKGILEQGWQADstTRMVLPRKPVAGALDVsFNK
Q99759	S399	Sugiyama	MAP3K3 MAPKKK3 MEKK3	CYDVDtGRELASKQVQFDPDsPETSKEVSALECEIQLLKNL
Q9BQE3	T334	Sugiyama	TUBA1C TUBA6	ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q9BQE3	T80	Sugiyama	TUBA1C TUBA6	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H173	T123	Sugiyama	SIL1 UNQ545/PRO836	KLQYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAE
Q9H173	T125	Sugiyama	SIL1 UNQ545/PRO836	QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9H173	Y126	Sugiyama	SIL1 UNQ545/PRO836	YEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEMES
Q9H4A3	S1261	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GIPTSSLTQVVHSAGRRFIVsPVPEsRLRESKVFPSEITDT
Q9H6F5	S91	Sugiyama	CCDC86 CYCLON	RLQQGAGLEsPQGQPEPGAAsPQRQQDLHLEsPQRQPEysP
Q9NQE9	T47	Sugiyama	HINT3	ssVGTCEAAGKsPEPKDyDstCVFCRIAGRQDPGTELLHCE
Q9NWB6	S77	Sugiyama	ARGLU1	RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9NY27	S311	Sugiyama	PPP4R2 SBBI57	CTRQHCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDD
Q9NY27	S315	Sugiyama	PPP4R2 SBBI57	HCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDDALTV
Q9NY27	T314	Sugiyama	PPP4R2 SBBI57	QHCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDDALT
Q9UBW7	T157	Sugiyama	ZMYM2 FIM RAMP ZNF198	NFIERRPPETKNRTNDVDFStSSFSRSKVNAGMGNSGITTE
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S1648	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S351	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	PssPYEDKDKDKKEKsAtRPsPsPERsstGPEPPAPtPLLA
Q9UQ35	S353	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPYEDKDKDKKEKsAtRPsPsPERsstGPEPPAPtPLLAER
Q9UQ35	S876	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	tsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGssP
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2U5	S393	Sugiyama	MAP3K2 MAPKKK2 MEKK2	CYDVDTGRELAVKQVQFDPDsPETSKEVNALECEIQLLKNL
Q9Y2U5	S514	Sugiyama	MAP3K2 MAPKKK2 MEKK2	TGNVKLGDFGASKRLQtICLsGtGMKsVtGtPYWMSPEVIS
Q9Y2U5	T510	Sugiyama	MAP3K2 MAPKKK2 MEKK2	LRDSTGNVKLGDFGASKRLQtICLsGtGMKsVtGtPYWMSP
Q9Y2U5	T516	Sugiyama	MAP3K2 MAPKKK2 MEKK2	NVKLGDFGASKRLQtICLsGtGMKsVtGtPYWMSPEVISGE

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Axon guidance	R-HSA-422475	1.677087e-09	8.775
Nervous system development	R-HSA-9675108	1.607461e-08	7.794
Apoptotic execution phase	R-HSA-75153	4.300557e-08	7.366
Semaphorin interactions	R-HSA-373755	2.517388e-07	6.599
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.513474e-07	6.600
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.980016e-07	6.526
Signal Transduction	R-HSA-162582	4.853756e-06	5.314
EPH-Ephrin signaling	R-HSA-2682334	2.327990e-05	4.633
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.303128e-05	4.481
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	4.222507e-05	4.374
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.267114e-04	3.370
Signaling by ALK in cancer	R-HSA-9700206	4.267114e-04	3.370
Cell Cycle	R-HSA-1640170	5.217425e-04	3.283
Signaling by Hippo	R-HSA-2028269	5.535763e-04	3.257
Neutrophil degranulation	R-HSA-6798695	6.651721e-04	3.177
PCP/CE pathway	R-HSA-4086400	6.582316e-04	3.182
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	9.682617e-04	3.014
CRMPs in Sema3A signaling	R-HSA-399956	1.469726e-03	2.833
Type I hemidesmosome assembly	R-HSA-446107	1.673380e-03	2.776
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.673380e-03	2.776
Interleukin-12 signaling	R-HSA-9020591	1.780407e-03	2.749
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.052634e-03	2.688
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.586286e-03	2.587
Sema4D in semaphorin signaling	R-HSA-400685	3.095261e-03	2.509
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.245040e-03	2.372
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.245040e-03	2.372
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.173831e-03	2.379
Ephrin signaling	R-HSA-3928664	4.173831e-03	2.379
Signaling by ERBB2	R-HSA-1227986	4.197537e-03	2.377
Signaling by NTRKs	R-HSA-166520	4.196101e-03	2.377
Apoptosis	R-HSA-109581	3.941198e-03	2.404
Programmed Cell Death	R-HSA-5357801	3.658125e-03	2.437
Interleukin-12 family signaling	R-HSA-447115	4.818308e-03	2.317
p75 NTR receptor-mediated signalling	R-HSA-193704	4.861069e-03	2.313
Signaling by VEGF	R-HSA-194138	5.236505e-03	2.281
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.765820e-03	2.239
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	6.286742e-03	2.202
Nuclear Receptor transcription pathway	R-HSA-383280	6.357148e-03	2.197
Signaling by LTK	R-HSA-9842663	6.286742e-03	2.202
Interleukin-37 signaling	R-HSA-9008059	6.305368e-03	2.200
mRNA 3'-end processing	R-HSA-72187	6.477159e-03	2.189
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.663815e-03	2.176
Signaling by ROBO receptors	R-HSA-376176	6.672477e-03	2.176
Cell Cycle, Mitotic	R-HSA-69278	7.045130e-03	2.152
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.400567e-03	2.131
Breakdown of the nuclear lamina	R-HSA-352238	8.308991e-03	2.080
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	8.051630e-03	2.094
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	8.051630e-03	2.094
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	8.383866e-03	2.077
NRAGE signals death through JNK	R-HSA-193648	9.317941e-03	2.031
MAPK family signaling cascades	R-HSA-5683057	9.953125e-03	2.002
Nuclear Envelope Breakdown	R-HSA-2980766	1.015414e-02	1.993
Cohesin Loading onto Chromatin	R-HSA-2470946	1.082285e-02	1.966
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.082285e-02	1.966
Cation-coupled Chloride cotransporters	R-HSA-426117	1.082285e-02	1.966
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.434213e-02	1.843
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.434213e-02	1.843
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.434213e-02	1.843
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.434213e-02	1.843
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.434213e-02	1.843
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.434213e-02	1.843
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.434213e-02	1.843
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.434213e-02	1.843
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.434213e-02	1.843
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.434213e-02	1.843
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.434213e-02	1.843
Signaling by MRAS-complex mutants	R-HSA-9660537	1.394071e-02	1.856
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.394071e-02	1.856
HSF1 activation	R-HSA-3371511	1.414194e-02	1.849
Signalling to ERKs	R-HSA-187687	1.274007e-02	1.895
Mitotic Anaphase	R-HSA-68882	1.210100e-02	1.917
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.259404e-02	1.900
RNA Polymerase II Transcription Termination	R-HSA-73856	1.406294e-02	1.852
Death Receptor Signaling	R-HSA-73887	1.271729e-02	1.896
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.438833e-02	1.842
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.212061e-02	1.916
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.451610e-02	1.838
Regulated proteolysis of p75NTR	R-HSA-193692	1.751663e-02	1.757
M Phase	R-HSA-68886	1.737938e-02	1.760
L1CAM interactions	R-HSA-373760	1.640797e-02	1.785
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.638317e-02	1.786
Signaling by PTK6	R-HSA-8848021	1.638317e-02	1.786
Mitotic Prometaphase	R-HSA-68877	1.754822e-02	1.756
Sensory processing of sound	R-HSA-9659379	1.854538e-02	1.732
Axonal growth stimulation	R-HSA-209563	2.176060e-02	1.662
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.176060e-02	1.662
MET activates RAP1 and RAC1	R-HSA-8875555	2.155617e-02	1.666
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.155617e-02	1.666
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	2.155617e-02	1.666
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.898521e-02	1.722
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.082319e-02	1.681
Meiotic synapsis	R-HSA-1221632	2.191532e-02	1.659
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.896760e-02	1.722
Signal attenuation	R-HSA-74749	2.155617e-02	1.666
Regulation of CDH11 function	R-HSA-9762292	2.155617e-02	1.666
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	2.176060e-02	1.662
Beta-catenin independent WNT signaling	R-HSA-3858494	2.335994e-02	1.632
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.457003e-02	1.610
Oncogenic MAPK signaling	R-HSA-6802957	2.687513e-02	1.571
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.742973e-02	1.562
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	2.915585e-02	1.535
Signalling to RAS	R-HSA-167044	3.101791e-02	1.508
Cell Cycle Checkpoints	R-HSA-69620	2.938178e-02	1.532
Glycolysis	R-HSA-70171	3.099159e-02	1.509
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.103066e-02	1.508
Activation of RAC1	R-HSA-428540	3.103066e-02	1.508
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.103066e-02	1.508
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	3.107345e-02	1.508
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.246501e-02	1.489
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.295155e-02	1.482
Activation of ATR in response to replication stress	R-HSA-176187	3.295155e-02	1.482
SHC-related events triggered by IGF1R	R-HSA-2428933	3.646014e-02	1.438
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.646014e-02	1.438
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.609524e-02	1.443
Regulation of TP53 Activity	R-HSA-5633007	3.344893e-02	1.476
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	4.396615e-02	1.357
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	4.396615e-02	1.357
IRS activation	R-HSA-74713	4.022995e-02	1.395
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	3.994995e-02	1.398
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.022995e-02	1.395
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.332794e-02	1.363
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.022995e-02	1.395
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	4.022995e-02	1.395
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.234307e-02	1.373
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.377234e-02	1.359
G alpha (12/13) signalling events	R-HSA-416482	4.313589e-02	1.365
NrCAM interactions	R-HSA-447038	4.022995e-02	1.395
Gluconeogenesis	R-HSA-70263	4.292631e-02	1.367
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.485224e-02	1.348
RET signaling	R-HSA-8853659	4.660345e-02	1.332
Platelet activation, signaling and aggregation	R-HSA-76002	4.731814e-02	1.325
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.795888e-02	1.319
Neurodegenerative Diseases	R-HSA-8863678	4.795888e-02	1.319
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.104103e-02	1.292
NRIF signals cell death from the nucleus	R-HSA-205043	4.867058e-02	1.313
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.104103e-02	1.292
MAPK1/MAPK3 signaling	R-HSA-5684996	5.232999e-02	1.281
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	5.104103e-02	1.292
Cell-Cell communication	R-HSA-1500931	5.443788e-02	1.264
Sodium-coupled phosphate cotransporters	R-HSA-427652	5.104103e-02	1.292
Interleukin-7 signaling	R-HSA-1266695	5.285267e-02	1.277
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.104103e-02	1.292
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	5.084761e-02	1.294
SLC-mediated transport of inorganic anions	R-HSA-9958790	5.451748e-02	1.263
Drug-mediated inhibition of MET activation	R-HSA-9734091	8.600184e-02	1.065
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	8.600184e-02	1.065
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	8.600184e-02	1.065
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	8.600184e-02	1.065
Hereditary fructose intolerance	R-HSA-5657560	8.600184e-02	1.065
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	8.600184e-02	1.065
NFG and proNGF binds to p75NTR	R-HSA-205017	1.261917e-01	0.899
TRAF3 deficiency - HSE	R-HSA-5602571	1.261917e-01	0.899
XAV939 stabilizes AXIN	R-HSA-5545619	1.261917e-01	0.899
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-5619099	1.261917e-01	0.899
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	1.261917e-01	0.899
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	1.261917e-01	0.899
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.646167e-01	0.784
Signalling to ERK5	R-HSA-198765	1.646167e-01	0.784
Defective PAPSS2 causes SEMD-PA	R-HSA-3560796	1.646167e-01	0.784
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	R-HSA-5619104	1.646167e-01	0.784
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.275679e-02	1.202
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	7.527701e-02	1.123
SOS-mediated signalling	R-HSA-112412	7.527701e-02	1.123
Disinhibition of SNARE formation	R-HSA-114516	7.527701e-02	1.123
MET interacts with TNS proteins	R-HSA-8875513	2.013542e-01	0.696
MET activates PTPN11	R-HSA-8865999	2.013542e-01	0.696
Defective ABCC2 causes DJS	R-HSA-5679001	2.013542e-01	0.696
Defective GCLC causes HAGGSD	R-HSA-5578999	2.013542e-01	0.696
ARMS-mediated activation	R-HSA-170984	1.023648e-01	0.990
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	1.023648e-01	0.990
ALK mutants bind TKIs	R-HSA-9700645	1.023648e-01	0.990
NADE modulates death signalling	R-HSA-205025	2.364783e-01	0.626
Nucleotide catabolism defects	R-HSA-9735786	2.364783e-01	0.626
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	2.364783e-01	0.626
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.364783e-01	0.626
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	R-HSA-2978092	2.364783e-01	0.626
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.364783e-01	0.626
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.364783e-01	0.626
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	1.167655e-01	0.933
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.261456e-02	1.203
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.316361e-01	0.881
Activated NTRK3 signals through RAS	R-HSA-9034864	1.316361e-01	0.881
NOSIP mediated eNOS trafficking	R-HSA-203754	2.700596e-01	0.569
Activated NTRK2 signals through RAS	R-HSA-9026519	1.469076e-01	0.833
Signaling by GSK3beta mutants	R-HSA-5339716	1.469076e-01	0.833
MET activates RAS signaling	R-HSA-8851805	1.625161e-01	0.789
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.625161e-01	0.789
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.625161e-01	0.789
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.625161e-01	0.789
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.625161e-01	0.789
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.625161e-01	0.789
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.625161e-01	0.789
Nef Mediated CD8 Down-regulation	R-HSA-182218	3.021659e-01	0.520
IkBA variant leads to EDA-ID	R-HSA-5603029	3.021659e-01	0.520
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.021659e-01	0.520
Signaling by RNF43 mutants	R-HSA-5340588	3.021659e-01	0.520
Adenylate cyclase activating pathway	R-HSA-170660	1.784026e-01	0.749
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.234044e-01	0.909
Retrograde neurotrophin signalling	R-HSA-177504	1.945127e-01	0.711
Erythropoietin activates STAT5	R-HSA-9027283	3.328619e-01	0.478
G2/M DNA replication checkpoint	R-HSA-69478	3.328619e-01	0.478
FGFR2 alternative splicing	R-HSA-6803529	1.333836e-01	0.875
Erythropoietin activates RAS	R-HSA-9027284	2.107959e-01	0.676
Adenylate cyclase inhibitory pathway	R-HSA-170670	2.107959e-01	0.676
Beta-catenin phosphorylation cascade	R-HSA-196299	2.107959e-01	0.676
TRAF6 mediated NF-kB activation	R-HSA-933542	1.541298e-01	0.812
RUNX3 regulates WNT signaling	R-HSA-8951430	3.622094e-01	0.441
MET activates PI3K/AKT signaling	R-HSA-8851907	3.622094e-01	0.441
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.622094e-01	0.441
IFNG signaling activates MAPKs	R-HSA-9732724	3.622094e-01	0.441
Recycling of eIF2:GDP	R-HSA-72731	3.622094e-01	0.441
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.230648e-01	0.910
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.387262e-01	0.858
Interaction between L1 and Ankyrins	R-HSA-445095	1.869401e-01	0.728
EPHA-mediated growth cone collapse	R-HSA-3928663	1.869401e-01	0.728
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.869401e-01	0.728
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.869401e-01	0.728
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.602405e-01	0.585
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.602405e-01	0.585
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	2.602405e-01	0.585
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.902677e-01	0.409
Formation of annular gap junctions	R-HSA-196025	3.902677e-01	0.409
MET receptor recycling	R-HSA-8875656	3.902677e-01	0.409
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.108627e-01	0.955
Telomere Extension By Telomerase	R-HSA-171319	1.982545e-01	0.703
HIV elongation arrest and recovery	R-HSA-167287	1.982545e-01	0.703
Pausing and recovery of HIV elongation	R-HSA-167290	1.982545e-01	0.703
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.097279e-01	0.678
Amplification of signal from the kinetochores	R-HSA-141424	6.519615e-02	1.186
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	6.519615e-02	1.186
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	1.636023e-01	0.786
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.040674e-01	0.983
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.040674e-01	0.983
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.213431e-01	0.655
Gap junction degradation	R-HSA-190873	4.170932e-01	0.380
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	1.810117e-01	0.742
Signaling by RAF1 mutants	R-HSA-9656223	1.810117e-01	0.742
HIV Transcription Initiation	R-HSA-167161	1.810117e-01	0.742
RNA Polymerase II Transcription Initiation	R-HSA-75953	1.810117e-01	0.742
AURKA Activation by TPX2	R-HSA-8854518	1.199331e-01	0.921
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.330831e-01	0.632
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.330831e-01	0.632
Negative regulation of MET activity	R-HSA-6807004	3.097886e-01	0.509
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.311372e-01	0.882
RNA Polymerase II Promoter Escape	R-HSA-73776	1.990012e-01	0.701
IPs transport between nucleus and cytosol	R-HSA-1855170	2.568720e-01	0.590
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.261809e-01	0.487
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.261809e-01	0.487
SHC-mediated cascade:FGFR3	R-HSA-5654704	3.261809e-01	0.487
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.427400e-01	0.354
2-LTR circle formation	R-HSA-164843	4.427400e-01	0.354
Folding of actin by CCT/TriC	R-HSA-390450	4.427400e-01	0.354
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	2.175007e-01	0.663
Nucleosome assembly	R-HSA-774815	2.175007e-01	0.663
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.175007e-01	0.663
snRNP Assembly	R-HSA-191859	1.864695e-01	0.729
Metabolism of non-coding RNA	R-HSA-194441	1.864695e-01	0.729
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.612039e-01	0.793
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.269198e-01	0.644
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.269198e-01	0.644
Signaling downstream of RAS mutants	R-HSA-9649948	2.269198e-01	0.644
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	3.424681e-01	0.465
SHC-mediated cascade:FGFR4	R-HSA-5654719	3.424681e-01	0.465
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.424681e-01	0.465
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	3.424681e-01	0.465
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	2.809682e-01	0.551
Centrosome maturation	R-HSA-380287	1.739954e-01	0.759
mRNA Splicing - Major Pathway	R-HSA-72163	6.198259e-02	1.208
Voltage gated Potassium channels	R-HSA-1296072	3.174325e-01	0.498
mRNA Splicing	R-HSA-72172	8.574445e-02	1.067
MET promotes cell motility	R-HSA-8875878	3.296184e-01	0.482
SHC-mediated cascade:FGFR1	R-HSA-5654688	3.904851e-01	0.408
Deadenylation of mRNA	R-HSA-429947	3.904851e-01	0.408
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	3.539618e-01	0.451
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.498670e-01	0.824
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.732305e-01	0.563
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.368708e-01	0.360
SHC-mediated cascade:FGFR2	R-HSA-5654699	4.368708e-01	0.360
Packaging Of Telomere Ends	R-HSA-171306	4.368708e-01	0.360
GABA B receptor activation	R-HSA-977444	3.902374e-01	0.409
Activation of GABAB receptors	R-HSA-991365	3.902374e-01	0.409
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.972398e-01	0.527
Cap-dependent Translation Initiation	R-HSA-72737	3.686953e-01	0.433
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.410910e-01	0.355
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.410910e-01	0.355
Transcription of the HIV genome	R-HSA-167172	1.311372e-01	0.882
Signaling by EGFR in Cancer	R-HSA-1643713	4.216146e-01	0.375
Eukaryotic Translation Initiation	R-HSA-72613	3.686953e-01	0.433
Ribosome-associated quality control	R-HSA-9948299	2.662117e-01	0.575
DAP12 signaling	R-HSA-2424491	2.213431e-01	0.655
HIV Transcription Elongation	R-HSA-167169	3.539618e-01	0.451
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.410910e-01	0.355
p75NTR signals via NF-kB	R-HSA-193639	2.107959e-01	0.676
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.038716e-01	0.691
Signaling by MET	R-HSA-6806834	3.626473e-01	0.441
Apoptosis induced DNA fragmentation	R-HSA-140342	1.167655e-01	0.933
FCERI mediated MAPK activation	R-HSA-2871796	3.255423e-01	0.487
Chromosome Maintenance	R-HSA-73886	2.651203e-01	0.577
Extension of Telomeres	R-HSA-180786	3.555422e-01	0.449
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.884504e-01	0.540
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.011131e-01	0.995
p75NTR regulates axonogenesis	R-HSA-193697	1.023648e-01	0.990
Integrin signaling	R-HSA-354192	1.011131e-01	0.995
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.539618e-01	0.451
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	3.904851e-01	0.408
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.660963e-01	0.436
G0 and Early G1	R-HSA-1538133	2.449314e-01	0.611
Chaperone Mediated Autophagy	R-HSA-9613829	8.654682e-02	1.063
Axonal growth inhibition (RHOA activation)	R-HSA-193634	8.850852e-02	1.053
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.011131e-01	0.995
MAP2K and MAPK activation	R-HSA-5674135	1.810117e-01	0.742
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	3.781916e-01	0.422
PI3K/AKT activation	R-HSA-198203	1.167655e-01	0.933
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.700596e-01	0.569
Attenuation phase	R-HSA-3371568	6.316147e-02	1.200
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.602405e-01	0.585
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	3.586277e-01	0.445
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.417987e-01	0.466
Peptide chain elongation	R-HSA-156902	4.415689e-01	0.355
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	3.507667e-01	0.455
Recycling pathway of L1	R-HSA-437239	1.048783e-01	0.979
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.175007e-01	0.663
Signaling by RAS mutants	R-HSA-6802949	2.269198e-01	0.644
Eukaryotic Translation Elongation	R-HSA-156842	1.795273e-01	0.746
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.675479e-01	0.776
Inactivation of CDC42 and RAC1	R-HSA-428543	1.023648e-01	0.990
Regulation of gap junction activity	R-HSA-191650	2.364783e-01	0.626
NF-kB is activated and signals survival	R-HSA-209560	1.469076e-01	0.833
Translesion Synthesis by POLH	R-HSA-110320	9.526583e-02	1.021
E2F mediated regulation of DNA replication	R-HSA-113510	9.526583e-02	1.021
Telomere C-strand synthesis initiation	R-HSA-174430	2.107959e-01	0.676
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.902677e-01	0.409
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.913272e-02	1.228
Trafficking of AMPA receptors	R-HSA-399719	2.330831e-01	0.632
RNA Polymerase I Transcription Termination	R-HSA-73863	4.368708e-01	0.360
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.900034e-02	1.051
Myogenesis	R-HSA-525793	5.800757e-02	1.237
ERK/MAPK targets	R-HSA-198753	3.261809e-01	0.487
Mismatch Repair	R-HSA-5358508	2.767898e-01	0.558
IGF1R signaling cascade	R-HSA-2428924	2.257280e-01	0.646
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.700685e-01	0.432
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.800757e-02	1.237
Signaling by WNT in cancer	R-HSA-4791275	9.423542e-02	1.026
Neurexins and neuroligins	R-HSA-6794361	1.363785e-01	0.865
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.527701e-02	1.123
TNFR1-mediated ceramide production	R-HSA-5626978	2.364783e-01	0.626
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	3.021659e-01	0.520
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.328619e-01	0.478
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	3.622094e-01	0.441
PTK6 Expression	R-HSA-8849473	3.622094e-01	0.441
Polymerase switching on the C-strand of the telomere	R-HSA-174411	1.648596e-01	0.783
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	2.767898e-01	0.558
G2/M DNA damage checkpoint	R-HSA-69473	8.013199e-02	1.096
RAF activation	R-HSA-5673000	2.809682e-01	0.551
FCGR3A-mediated phagocytosis	R-HSA-9664422	1.745346e-01	0.758
Parasite infection	R-HSA-9664407	1.745346e-01	0.758
Leishmania phagocytosis	R-HSA-9664417	1.745346e-01	0.758
Signaling by ERBB2 in Cancer	R-HSA-1227990	8.117851e-02	1.091
MTOR signalling	R-HSA-165159	1.899383e-01	0.721
Negative regulation of MAPK pathway	R-HSA-5675221	1.810117e-01	0.742
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.541298e-01	0.812
Adipogenesis	R-HSA-9843745	3.430078e-01	0.465
Prolonged ERK activation events	R-HSA-169893	2.272061e-01	0.644
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.338607e-01	0.631
HSF1-dependent transactivation	R-HSA-3371571	1.297704e-01	0.887
Regulation of CDH1 Function	R-HSA-9764561	1.715196e-01	0.766
G2/M Checkpoints	R-HSA-69481	1.119678e-01	0.951
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.541298e-01	0.812
Late Phase of HIV Life Cycle	R-HSA-162599	2.959478e-01	0.529
G2/M Transition	R-HSA-69275	2.173657e-01	0.663
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.261456e-02	1.203
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.021659e-01	0.520
MET Receptor Activation	R-HSA-6806942	3.328619e-01	0.478
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.622094e-01	0.441
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	2.602405e-01	0.585
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.586277e-01	0.445
Regulation of RAS by GAPs	R-HSA-5658442	2.655229e-01	0.576
Mitotic G2-G2/M phases	R-HSA-453274	2.265988e-01	0.645
Vasopressin-like receptors	R-HSA-388479	2.364783e-01	0.626
Mitotic Spindle Checkpoint	R-HSA-69618	1.316700e-01	0.881
Asymmetric localization of PCP proteins	R-HSA-4608870	4.259852e-01	0.371
Mitophagy	R-HSA-5205647	2.809682e-01	0.551
GPVI-mediated activation cascade	R-HSA-114604	1.307979e-01	0.883
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	3.424681e-01	0.465
Golgi-to-ER retrograde transport	R-HSA-8856688	2.262940e-01	0.645
Epigenetic regulation of gene expression	R-HSA-212165	3.762223e-01	0.425
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.507667e-01	0.455
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	6.342109e-02	1.198
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.052535e-01	0.515
Signaling by ERBB2 ECD mutants	R-HSA-9665348	8.654682e-02	1.063
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.097279e-01	0.678
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.230912e-01	0.910
RNA Polymerase III Transcription	R-HSA-74158	3.052535e-01	0.515
Cellular response to heat stress	R-HSA-3371556	8.792514e-02	1.056
Signaling by WNT	R-HSA-195721	1.323229e-01	0.878
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	1.261917e-01	0.899
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	1.261917e-01	0.899
Manipulation of host energy metabolism	R-HSA-9636667	1.261917e-01	0.899
MET activates STAT3	R-HSA-8875791	2.013542e-01	0.696
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.364783e-01	0.626
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	1.167655e-01	0.933
Ionotropic activity of kainate receptors	R-HSA-451306	1.316361e-01	0.881
NTRK2 activates RAC1	R-HSA-9032759	2.700596e-01	0.569
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.469076e-01	0.833
VLDLR internalisation and degradation	R-HSA-8866427	1.625161e-01	0.789
Ceramide signalling	R-HSA-193681	3.021659e-01	0.520
Phosphorylation of Emi1	R-HSA-176417	3.021659e-01	0.520
CDC6 association with the ORC:origin complex	R-HSA-68689	3.021659e-01	0.520
Noncanonical activation of NOTCH3	R-HSA-9017802	3.021659e-01	0.520
NADPH regeneration	R-HSA-389542	3.328619e-01	0.478
mTORC1-mediated signalling	R-HSA-166208	1.333836e-01	0.875
Regulation of FZD by ubiquitination	R-HSA-4641263	2.602405e-01	0.585
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	3.902677e-01	0.409
FGFR1b ligand binding and activation	R-HSA-190370	3.902677e-01	0.409
PKA activation in glucagon signalling	R-HSA-164378	2.767898e-01	0.558
Unwinding of DNA	R-HSA-176974	4.170932e-01	0.380
Intra-Golgi traffic	R-HSA-6811438	1.810117e-01	0.742
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	2.688893e-01	0.570
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	7.759628e-02	1.110
Notch-HLH transcription pathway	R-HSA-350054	3.586277e-01	0.445
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.174325e-01	0.498
Cristae formation	R-HSA-8949613	4.368708e-01	0.360
Separation of Sister Chromatids	R-HSA-2467813	2.015928e-01	0.696
Viral Messenger RNA Synthesis	R-HSA-168325	3.757186e-01	0.425
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.271922e-01	0.485
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.259852e-01	0.371
rRNA processing	R-HSA-72312	2.488513e-01	0.604
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.526553e-01	0.597
DAP12 interactions	R-HSA-2172127	4.141431e-01	0.383
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.526553e-01	0.597
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.714199e-01	0.566
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.097279e-01	0.678
G1 Phase	R-HSA-69236	4.141431e-01	0.383
Cyclin D associated events in G1	R-HSA-69231	4.141431e-01	0.383
Stabilization of p53	R-HSA-69541	3.417987e-01	0.466
Aggrephagy	R-HSA-9646399	3.539618e-01	0.451
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.714199e-01	0.566
EPHB-mediated forward signaling	R-HSA-3928662	8.792591e-02	1.056
Protein-protein interactions at synapses	R-HSA-6794362	1.298124e-01	0.887
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.326373e-01	0.478
Mitotic Prophase	R-HSA-68875	1.544643e-01	0.811
RAF/MAP kinase cascade	R-HSA-5673001	7.027106e-02	1.153
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.097279e-01	0.678
HIV Life Cycle	R-HSA-162587	2.663937e-01	0.574
HIV Infection	R-HSA-162906	1.520452e-01	0.818
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.043271e-01	0.982
Regulation of CDH11 Expression and Function	R-HSA-9759475	7.501067e-02	1.125
Downregulation of ERBB2 signaling	R-HSA-8863795	8.117851e-02	1.091
ROBO receptors bind AKAP5	R-HSA-9010642	3.902677e-01	0.409
Long-term potentiation	R-HSA-9620244	4.061484e-01	0.391
Diseases associated with the TLR signaling cascade	R-HSA-5602358	3.539618e-01	0.451
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.539618e-01	0.451
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.539618e-01	0.451
Diseases of Immune System	R-HSA-5260271	3.539618e-01	0.451
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.763529e-01	0.424
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.061484e-01	0.391
Processing of DNA double-strand break ends	R-HSA-5693607	2.146690e-01	0.668
Formation of the cornified envelope	R-HSA-6809371	1.737355e-01	0.760
Nef and signal transduction	R-HSA-164944	6.275679e-02	1.202
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.023648e-01	0.990
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	1.023648e-01	0.990
p38MAPK events	R-HSA-171007	5.543188e-02	1.256
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.021659e-01	0.520
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.784026e-01	0.749
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.622094e-01	0.441
GPER1 signaling	R-HSA-9634597	1.108627e-01	0.955
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.688893e-01	0.570
Degradation of CDH1	R-HSA-9766229	2.557502e-01	0.592
RAB geranylgeranylation	R-HSA-8873719	3.656344e-01	0.437
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.113300e-01	0.507
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.011131e-01	0.995
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	9.340691e-02	1.030
Membrane Trafficking	R-HSA-199991	2.564978e-01	0.591
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.056229e-01	0.976
MyD88-independent TLR4 cascade	R-HSA-166166	3.113300e-01	0.507
DNA Repair	R-HSA-73894	1.406655e-01	0.852
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	2.763817e-01	0.558
Metabolism of RNA	R-HSA-8953854	2.486532e-01	0.604
Smooth Muscle Contraction	R-HSA-445355	5.985999e-02	1.223
Meiosis	R-HSA-1500620	1.298124e-01	0.887
Acyl chain remodelling of PS	R-HSA-1482801	4.061484e-01	0.391
Host Interactions of HIV factors	R-HSA-162909	1.737355e-01	0.760
Autophagy	R-HSA-9612973	9.841843e-02	1.007
Platelet degranulation	R-HSA-114608	1.940504e-01	0.712
Leishmania infection	R-HSA-9658195	2.840230e-01	0.547
Parasitic Infection Pathways	R-HSA-9824443	2.840230e-01	0.547
Ovarian tumor domain proteases	R-HSA-5689896	1.387262e-01	0.858
Kinesins	R-HSA-983189	1.941163e-01	0.712
Selective autophagy	R-HSA-9663891	2.732305e-01	0.563
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.982183e-01	0.400
Generation of second messenger molecules	R-HSA-202433	1.636023e-01	0.786
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.939260e-01	0.712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.770533e-01	0.752
DNA Double-Strand Break Repair	R-HSA-5693532	8.961757e-02	1.048
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.023648e-01	0.990
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	2.364783e-01	0.626
Signalling to p38 via RIT and RIN	R-HSA-187706	3.021659e-01	0.520
CD28 dependent Vav1 pathway	R-HSA-389359	1.784026e-01	0.749
Protein methylation	R-HSA-8876725	2.107959e-01	0.676
LDL remodeling	R-HSA-8964041	3.622094e-01	0.441
Ca2+ activated K+ channels	R-HSA-1296052	3.622094e-01	0.441
Synthesis of PIPs in the nucleus	R-HSA-8847453	3.622094e-01	0.441
TGFBR3 PTM regulation	R-HSA-9839383	3.902677e-01	0.409
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.933158e-01	0.533
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.568720e-01	0.590
EGFR Transactivation by Gastrin	R-HSA-2179392	4.427400e-01	0.354
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.864695e-01	0.729
Tight junction interactions	R-HSA-420029	4.061484e-01	0.391
Regulation of PTEN gene transcription	R-HSA-8943724	3.656344e-01	0.437
ESR-mediated signaling	R-HSA-8939211	2.712925e-01	0.567
Extra-nuclear estrogen signaling	R-HSA-9009391	3.903039e-01	0.409
S Phase	R-HSA-69242	2.185181e-01	0.661
PKMTs methylate histone lysines	R-HSA-3214841	1.722302e-01	0.764
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.234044e-01	0.909
Chromatin organization	R-HSA-4839726	4.349175e-01	0.362
G1/S Transition	R-HSA-69206	4.410910e-01	0.355
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.982183e-01	0.400
MHC class II antigen presentation	R-HSA-2132295	1.688168e-01	0.773
TCR signaling	R-HSA-202403	3.113300e-01	0.507
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.781916e-01	0.422
Innate Immune System	R-HSA-168249	2.160270e-01	0.665
G1/S DNA Damage Checkpoints	R-HSA-69615	3.958378e-01	0.402
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.224930e-01	0.912
Pentose phosphate pathway	R-HSA-71336	3.417987e-01	0.466
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	3.857885e-01	0.414
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.106545e-01	0.676
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.224930e-01	0.912
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.224930e-01	0.912
Response of endothelial cells to shear stress	R-HSA-9860931	7.906209e-02	1.102
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.152800e-01	0.938
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.276715e-01	0.894
Cell junction organization	R-HSA-446728	8.490071e-02	1.071
Estrogen-dependent gene expression	R-HSA-9018519	2.545832e-01	0.594
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.275679e-02	1.202
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.328619e-01	0.478
Rap1 signalling	R-HSA-392517	2.933158e-01	0.533
Regulation of CDH11 gene transcription	R-HSA-9762293	4.170932e-01	0.380
Nuclear import of Rev protein	R-HSA-180746	2.809682e-01	0.551
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.660963e-01	0.436
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.368708e-01	0.360
tRNA processing in the nucleus	R-HSA-6784531	3.857885e-01	0.414
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	4.194230e-01	0.377
Macroautophagy	R-HSA-1632852	1.792028e-01	0.747
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.824811e-01	0.739
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.036558e-01	0.984
The NLRP3 inflammasome	R-HSA-844456	2.933158e-01	0.533
MAPK6/MAPK4 signaling	R-HSA-5687128	6.211813e-02	1.207
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.437006e-01	0.613
Signal transduction by L1	R-HSA-445144	3.097886e-01	0.509
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.259852e-01	0.371
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.259852e-01	0.371
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.750356e-01	0.426
DNA Double Strand Break Response	R-HSA-5693606	2.503645e-01	0.601
Cellular Senescence	R-HSA-2559583	2.869883e-01	0.542
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.350300e-01	0.475
Adherens junctions interactions	R-HSA-418990	3.847741e-01	0.415
Cell-cell junction organization	R-HSA-421270	3.373159e-01	0.472
Deubiquitination	R-HSA-5688426	1.813252e-01	0.742
Homology Directed Repair	R-HSA-5693538	2.464941e-01	0.608
Developmental Biology	R-HSA-1266738	1.285966e-01	0.891
MECP2 regulates transcription factors	R-HSA-9022707	7.527701e-02	1.123
Adrenoceptors	R-HSA-390696	8.850852e-02	1.053
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.364783e-01	0.626
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.167655e-01	0.933
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.469076e-01	0.833
Synaptic adhesion-like molecules	R-HSA-8849932	8.654682e-02	1.063
CLEC7A/inflammasome pathway	R-HSA-5660668	3.021659e-01	0.520
Regulation of KIT signaling	R-HSA-1433559	1.945127e-01	0.711
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.328619e-01	0.478
Negative regulation of FLT3	R-HSA-9706369	2.272061e-01	0.644
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.622094e-01	0.441
Phase 3 - rapid repolarisation	R-HSA-5576890	3.622094e-01	0.441
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.902677e-01	0.409
PKA activation	R-HSA-163615	2.767898e-01	0.558
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.170932e-01	0.380
WNT mediated activation of DVL	R-HSA-201688	4.170932e-01	0.380
MAPK3 (ERK1) activation	R-HSA-110056	4.427400e-01	0.354
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.424681e-01	0.465
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.809682e-01	0.551
Interactions of Rev with host cellular proteins	R-HSA-177243	3.539618e-01	0.451
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.539618e-01	0.451
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.660963e-01	0.436
Urea cycle	R-HSA-70635	4.216146e-01	0.375
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	3.575322e-01	0.447
Cellular responses to mechanical stimuli	R-HSA-9855142	1.193340e-01	0.923
Regulation of necroptotic cell death	R-HSA-5675482	2.568720e-01	0.590
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.342109e-02	1.198
Nephrin family interactions	R-HSA-373753	3.097886e-01	0.509
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.261809e-01	0.487
Post NMDA receptor activation events	R-HSA-438064	4.328763e-01	0.364
PKR-mediated signaling	R-HSA-9833482	1.056229e-01	0.976
Glucose metabolism	R-HSA-70326	7.572312e-02	1.121
Ub-specific processing proteases	R-HSA-5689880	3.639949e-01	0.439
Cellular responses to stress	R-HSA-2262752	2.784579e-01	0.555
Other semaphorin interactions	R-HSA-416700	5.543188e-02	1.256
Regulation of NPAS4 gene transcription	R-HSA-9768777	4.170932e-01	0.380
GP1b-IX-V activation signalling	R-HSA-430116	4.170932e-01	0.380
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.097277e-01	0.678
Azathioprine ADME	R-HSA-9748787	2.655229e-01	0.576
ABC-family proteins mediated transport	R-HSA-382556	3.823876e-01	0.417
Immune System	R-HSA-168256	1.216211e-01	0.915
Signaling by EGFR	R-HSA-177929	1.642265e-01	0.785
Signaling by FGFR2	R-HSA-5654738	2.076701e-01	0.683
Cellular responses to stimuli	R-HSA-8953897	2.303750e-01	0.638
Chromatin modifying enzymes	R-HSA-3247509	3.574915e-01	0.447
Interleukin-2 signaling	R-HSA-9020558	1.316361e-01	0.881
Plasma lipoprotein assembly	R-HSA-8963898	3.904851e-01	0.408
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.296184e-01	0.482
Netrin-1 signaling	R-HSA-373752	8.792591e-02	1.056
Uptake and function of diphtheria toxin	R-HSA-5336415	7.527701e-02	1.123
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.023648e-01	0.990
Respiratory syncytial virus genome replication	R-HSA-9834752	1.023648e-01	0.990
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.700596e-01	0.569
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.021659e-01	0.520
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.021659e-01	0.520
VLDL assembly	R-HSA-8866423	3.328619e-01	0.478
Leukotriene receptors	R-HSA-391906	3.328619e-01	0.478
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.107959e-01	0.676
Syndecan interactions	R-HSA-3000170	1.436316e-01	0.843
Synthesis of PG	R-HSA-1483148	2.437006e-01	0.613
Interleukin-1 processing	R-HSA-448706	4.170932e-01	0.380
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.586277e-01	0.445
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.296184e-01	0.482
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.824811e-01	0.739
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.377425e-01	0.359
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.216146e-01	0.375
ISG15 antiviral mechanism	R-HSA-1169408	1.739954e-01	0.759
Transcriptional regulation by RUNX1	R-HSA-8878171	4.279845e-01	0.369
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.930943e-01	0.533
Interleukin-1 family signaling	R-HSA-446652	1.492259e-01	0.826
Influenza Infection	R-HSA-168255	3.996257e-01	0.398
Signaling by FGFR	R-HSA-190236	2.229099e-01	0.652
DCC mediated attractive signaling	R-HSA-418885	2.107959e-01	0.676
Cellular response to mitochondrial stress	R-HSA-9840373	4.170932e-01	0.380
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.170932e-01	0.380
Josephin domain DUBs	R-HSA-5689877	4.427400e-01	0.354
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.417987e-01	0.466
Signaling by FGFR1	R-HSA-5654736	3.252861e-01	0.488
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.081916e-01	0.682
PIP3 activates AKT signaling	R-HSA-1257604	3.459767e-01	0.461
Signaling by SCF-KIT	R-HSA-1433557	8.261820e-02	1.083
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.656344e-01	0.437
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.092278e-01	0.962
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.857885e-01	0.414
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	1.784026e-01	0.749
LDL clearance	R-HSA-8964038	3.586277e-01	0.445
Cytokine Signaling in Immune system	R-HSA-1280215	6.792492e-02	1.168
Diseases of DNA repair	R-HSA-9675135	9.905865e-02	1.004
Intracellular signaling by second messengers	R-HSA-9006925	2.792238e-01	0.554
Signaling by FGFR4	R-HSA-5654743	4.022243e-01	0.396
Maturation of nucleoprotein	R-HSA-9694631	9.526583e-02	1.021
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.021659e-01	0.520
Activated NTRK2 signals through FYN	R-HSA-9032500	3.902677e-01	0.409
Tie2 Signaling	R-HSA-210993	2.767898e-01	0.558
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.170932e-01	0.380
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.261809e-01	0.487
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.427400e-01	0.354
Receptor Mediated Mitophagy	R-HSA-8934903	4.427400e-01	0.354
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.930943e-01	0.533
G1/S-Specific Transcription	R-HSA-69205	3.052535e-01	0.515
TRP channels	R-HSA-3295583	4.216146e-01	0.375
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.464941e-01	0.608
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.656344e-01	0.437
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.656344e-01	0.437
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.656344e-01	0.437
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.656344e-01	0.437
MITF-M-dependent gene expression	R-HSA-9856651	3.450505e-01	0.462
Signaling by FGFR3	R-HSA-5654741	4.259852e-01	0.371
Signaling by Interleukins	R-HSA-449147	5.907696e-02	1.229
Calmodulin induced events	R-HSA-111933	3.052535e-01	0.515
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.452148e-01	0.838
Transcriptional Regulation by TP53	R-HSA-3700989	3.490951e-01	0.457
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.437006e-01	0.613
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.170932e-01	0.380
CaM pathway	R-HSA-111997	3.052535e-01	0.515
SARS-CoV-1-host interactions	R-HSA-9692914	4.376515e-01	0.359
Cellular response to chemical stress	R-HSA-9711123	3.186645e-01	0.497
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	3.781916e-01	0.422
NOD1/2 Signaling Pathway	R-HSA-168638	1.155347e-01	0.937
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.809682e-01	0.551
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.746395e-01	0.426
Ca-dependent events	R-HSA-111996	3.902374e-01	0.409
DAG and IP3 signaling	R-HSA-1489509	4.259852e-01	0.371
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.651203e-01	0.577
Signaling by Leptin	R-HSA-2586552	1.167655e-01	0.933
PI Metabolism	R-HSA-1483255	3.982183e-01	0.400
Mitochondrial calcium ion transport	R-HSA-8949215	1.234044e-01	0.909
Regulation of TP53 Degradation	R-HSA-6804757	3.052535e-01	0.515
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.296184e-01	0.482
Response of Mtb to phagocytosis	R-HSA-9637690	4.022243e-01	0.396
Signaling by ALK	R-HSA-201556	3.417987e-01	0.466
FLT3 Signaling	R-HSA-9607240	3.660963e-01	0.436
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.424681e-01	0.465
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.417987e-01	0.466
Interleukin-23 signaling	R-HSA-9020933	3.902677e-01	0.409
Signaling by PDGFR in disease	R-HSA-9671555	3.424681e-01	0.465
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.357114e-01	0.361
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.216146e-01	0.375
XBP1(S) activates chaperone genes	R-HSA-381038	2.582128e-01	0.588
IRE1alpha activates chaperones	R-HSA-381070	3.038432e-01	0.517
STING mediated induction of host immune responses	R-HSA-1834941	2.933158e-01	0.533
Regulation of TNFR1 signaling	R-HSA-5357905	4.377425e-01	0.359
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	3.417987e-01	0.466
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	3.555422e-01	0.449
Growth hormone receptor signaling	R-HSA-982772	3.746395e-01	0.426
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.455714e-01	0.351
Regulated Necrosis	R-HSA-5218859	4.455714e-01	0.351
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	4.494075e-01	0.347
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	4.519056e-01	0.345
Activation of kainate receptors upon glutamate binding	R-HSA-451326	4.519056e-01	0.345
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.519056e-01	0.345
Inflammasomes	R-HSA-622312	4.519056e-01	0.345
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.533052e-01	0.344
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.570456e-01	0.340
Co-stimulation by CD28	R-HSA-389356	4.609730e-01	0.336
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.651260e-01	0.332
Signaling by Erythropoietin	R-HSA-9006335	4.667090e-01	0.331
Downstream signaling of activated FGFR3	R-HSA-5654708	4.667090e-01	0.331
RHOBTB3 ATPase cycle	R-HSA-9706019	4.672600e-01	0.330
Signaling by APC mutants	R-HSA-4839744	4.672600e-01	0.330
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.672600e-01	0.330
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.672600e-01	0.330
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.672600e-01	0.330
vRNP Assembly	R-HSA-192905	4.672600e-01	0.330
Chylomicron assembly	R-HSA-8963888	4.672600e-01	0.330
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.672600e-01	0.330
Suppression of apoptosis	R-HSA-9635465	4.672600e-01	0.330
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.672600e-01	0.330
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.674410e-01	0.330
Transcriptional Regulation by MECP2	R-HSA-8986944	4.674410e-01	0.330
Toll-like Receptor Cascades	R-HSA-168898	4.709635e-01	0.327
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	4.710881e-01	0.327
DNA Damage Bypass	R-HSA-73893	4.724325e-01	0.326
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.724325e-01	0.326
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.724325e-01	0.326
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.748112e-01	0.323
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.768798e-01	0.322
Activation of the pre-replicative complex	R-HSA-68962	4.812722e-01	0.318
RNA Polymerase III Transcription Initiation	R-HSA-76046	4.812722e-01	0.318
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.812722e-01	0.318
Downstream signaling of activated FGFR4	R-HSA-5654716	4.812722e-01	0.318
Reproduction	R-HSA-1474165	4.839700e-01	0.315
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.842876e-01	0.315
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.842876e-01	0.315
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.844294e-01	0.315
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.844294e-01	0.315
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.844294e-01	0.315
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.844294e-01	0.315
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	4.907024e-01	0.309
ERKs are inactivated	R-HSA-202670	4.907024e-01	0.309
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	4.907024e-01	0.309
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.907024e-01	0.309
Signaling by AXIN mutants	R-HSA-4839735	4.907024e-01	0.309
Signaling by AMER1 mutants	R-HSA-4839748	4.907024e-01	0.309
Integration of provirus	R-HSA-162592	4.907024e-01	0.309
Gene expression (Transcription)	R-HSA-74160	4.930569e-01	0.307
Hedgehog ligand biogenesis	R-HSA-5358346	4.950089e-01	0.305
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.955453e-01	0.305
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.955453e-01	0.305
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	4.955877e-01	0.305
EGFR downregulation	R-HSA-182971	4.955877e-01	0.305
Downstream signal transduction	R-HSA-186763	4.955877e-01	0.305
Collagen formation	R-HSA-1474290	5.013328e-01	0.300
Formation of RNA Pol II elongation complex	R-HSA-112382	5.061149e-01	0.296
RNA Polymerase I Promoter Escape	R-HSA-73772	5.061149e-01	0.296
Orc1 removal from chromatin	R-HSA-68949	5.061149e-01	0.296
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	5.061149e-01	0.296
Transcriptional Regulation by NPAS4	R-HSA-9634815	5.061149e-01	0.296
DNA strand elongation	R-HSA-69190	5.096491e-01	0.293
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	5.096491e-01	0.293
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.128410e-01	0.290
p75NTR recruits signalling complexes	R-HSA-209543	5.131147e-01	0.290
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.131147e-01	0.290
Scavenging by Class F Receptors	R-HSA-3000484	5.131147e-01	0.290
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.131147e-01	0.290
Leading Strand Synthesis	R-HSA-69109	5.131147e-01	0.290
Polymerase switching	R-HSA-69091	5.131147e-01	0.290
IRAK1 recruits IKK complex	R-HSA-937039	5.131147e-01	0.290
Serotonin clearance from the synaptic cleft	R-HSA-380615	5.131147e-01	0.290
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.131147e-01	0.290
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.131147e-01	0.290
Interleukin-15 signaling	R-HSA-8983432	5.131147e-01	0.290
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.131147e-01	0.290
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.131147e-01	0.290
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	5.131147e-01	0.290
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.131147e-01	0.290
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.170927e-01	0.286
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.170927e-01	0.286
Regulation of PTEN stability and activity	R-HSA-8948751	5.170927e-01	0.286
Signaling by NOTCH1	R-HSA-1980143	5.221517e-01	0.282
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	5.234511e-01	0.281
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.234511e-01	0.281
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.234511e-01	0.281
Potassium Channels	R-HSA-1296071	5.261930e-01	0.279
Translation initiation complex formation	R-HSA-72649	5.279379e-01	0.277
Translation of Structural Proteins	R-HSA-9694635	5.313768e-01	0.275
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.345420e-01	0.272
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.345420e-01	0.272
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.345420e-01	0.272
Frs2-mediated activation	R-HSA-170968	5.345420e-01	0.272
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	5.345420e-01	0.272
Diseases of nucleotide metabolism	R-HSA-9735804	5.345420e-01	0.272
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.345420e-01	0.272
Platelet Adhesion to exposed collagen	R-HSA-75892	5.345420e-01	0.272
FGFR1c ligand binding and activation	R-HSA-190373	5.345420e-01	0.272
Formation of axial mesoderm	R-HSA-9796292	5.345420e-01	0.272
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.345420e-01	0.272
Maturation of nucleoprotein	R-HSA-9683610	5.345420e-01	0.272
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.345420e-01	0.272
Hemostasis	R-HSA-109582	5.369788e-01	0.270
DNA Damage Recognition in GG-NER	R-HSA-5696394	5.369893e-01	0.270
Striated Muscle Contraction	R-HSA-390522	5.369893e-01	0.270
Glucagon signaling in metabolic regulation	R-HSA-163359	5.369893e-01	0.270
Heme degradation	R-HSA-189483	5.369893e-01	0.270
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	5.369893e-01	0.270
Mitochondrial biogenesis	R-HSA-1592230	5.370611e-01	0.270
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	5.386464e-01	0.269
G alpha (z) signalling events	R-HSA-418597	5.386464e-01	0.269
Paracetamol ADME	R-HSA-9753281	5.386464e-01	0.269
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	5.405762e-01	0.267
Ribosomal scanning and start codon recognition	R-HSA-72702	5.492144e-01	0.260
TNF signaling	R-HSA-75893	5.492144e-01	0.260
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	5.502601e-01	0.259
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.502601e-01	0.259
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	5.502601e-01	0.259
Signal amplification	R-HSA-392518	5.502601e-01	0.259
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.502601e-01	0.259
Signaling by NOTCH2	R-HSA-1980145	5.502601e-01	0.259
NPAS4 regulates expression of target genes	R-HSA-9768919	5.502601e-01	0.259
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.502601e-01	0.259
HATs acetylate histones	R-HSA-3214847	5.504959e-01	0.259
FOXO-mediated transcription	R-HSA-9614085	5.504959e-01	0.259
PTEN Regulation	R-HSA-6807070	5.530846e-01	0.257
Unfolded Protein Response (UPR)	R-HSA-381119	5.530846e-01	0.257
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.550275e-01	0.256
cGMP effects	R-HSA-418457	5.550275e-01	0.256
HDL assembly	R-HSA-8963896	5.550275e-01	0.256
Signal regulatory protein family interactions	R-HSA-391160	5.550275e-01	0.256
P2Y receptors	R-HSA-417957	5.550275e-01	0.256
Zinc transporters	R-HSA-435354	5.550275e-01	0.256
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.550275e-01	0.256
TCF dependent signaling in response to WNT	R-HSA-201681	5.559978e-01	0.255
Synthesis of PA	R-HSA-1483166	5.596386e-01	0.252
Regulation of Apoptosis	R-HSA-169911	5.632609e-01	0.249
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	5.632609e-01	0.249
Downstream signaling of activated FGFR2	R-HSA-5654696	5.632609e-01	0.249
Downstream signaling of activated FGFR1	R-HSA-5654687	5.632609e-01	0.249
Interleukin-1 signaling	R-HSA-9020702	5.663579e-01	0.247
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.699160e-01	0.244
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.746127e-01	0.241
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	5.746127e-01	0.241
SHC1 events in EGFR signaling	R-HSA-180336	5.746127e-01	0.241
Translesion synthesis by REV1	R-HSA-110312	5.746127e-01	0.241
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.746127e-01	0.241
Transport and metabolism of PAPS	R-HSA-174362	5.746127e-01	0.241
Cell-extracellular matrix interactions	R-HSA-446353	5.746127e-01	0.241
Lysosphingolipid and LPA receptors	R-HSA-419408	5.746127e-01	0.241
Spry regulation of FGF signaling	R-HSA-1295596	5.746127e-01	0.241
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.746127e-01	0.241
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.759897e-01	0.240
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.759897e-01	0.240
Lysosome Vesicle Biogenesis	R-HSA-432720	5.759897e-01	0.240
RUNX2 regulates bone development	R-HSA-8941326	5.759897e-01	0.240
Peroxisomal protein import	R-HSA-9033241	5.800438e-01	0.237
Clathrin-mediated endocytosis	R-HSA-8856828	5.861035e-01	0.232
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.884453e-01	0.230
Degradation of AXIN	R-HSA-4641257	5.884453e-01	0.230
Degradation of DVL	R-HSA-4641258	5.884453e-01	0.230
Cleavage of the damaged purine	R-HSA-110331	5.884453e-01	0.230
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.884453e-01	0.230
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	5.896014e-01	0.229
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	5.896014e-01	0.229
GABA receptor activation	R-HSA-977443	5.900198e-01	0.229
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.933224e-01	0.227
Translesion synthesis by POLI	R-HSA-5656121	5.933369e-01	0.227
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.933369e-01	0.227
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	5.933369e-01	0.227
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.933369e-01	0.227
Phosphorylation of the APC/C	R-HSA-176412	5.933369e-01	0.227
Killing mechanisms	R-HSA-9664420	5.933369e-01	0.227
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.933369e-01	0.227
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.933369e-01	0.227
Fructose catabolism	R-HSA-70350	5.933369e-01	0.227
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.933369e-01	0.227
Regulation of NF-kappa B signaling	R-HSA-9758274	5.933369e-01	0.227
Activation of SMO	R-HSA-5635838	5.933369e-01	0.227
Attachment and Entry	R-HSA-9678110	5.933369e-01	0.227
Atorvastatin ADME	R-HSA-9754706	5.933369e-01	0.227
Muscle contraction	R-HSA-397014	5.959231e-01	0.225
MAP kinase activation	R-HSA-450294	5.998419e-01	0.222
PLC beta mediated events	R-HSA-112043	5.998419e-01	0.222
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.006271e-01	0.221
Purine salvage	R-HSA-74217	6.006271e-01	0.221
Depurination	R-HSA-73927	6.006271e-01	0.221
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	6.006271e-01	0.221
MITF-M-regulated melanocyte development	R-HSA-9730414	6.012872e-01	0.221
Nucleotide Excision Repair	R-HSA-5696398	6.047111e-01	0.218
Vesicle-mediated transport	R-HSA-5653656	6.083009e-01	0.216
Mitochondrial protein import	R-HSA-1268020	6.095083e-01	0.215
Heme signaling	R-HSA-9707616	6.095083e-01	0.215
Signaling by PDGF	R-HSA-186797	6.095083e-01	0.215
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.112381e-01	0.214
SHC1 events in ERBB4 signaling	R-HSA-1250347	6.112381e-01	0.214
Translesion synthesis by POLK	R-HSA-5655862	6.112381e-01	0.214
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.112381e-01	0.214
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.112381e-01	0.214
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.112381e-01	0.214
Heme assimilation	R-HSA-9927020	6.112381e-01	0.214
Acetylcholine regulates insulin secretion	R-HSA-399997	6.112381e-01	0.214
Galactose catabolism	R-HSA-70370	6.112381e-01	0.214
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.112381e-01	0.214
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.125351e-01	0.213
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.125351e-01	0.213
Plasma lipoprotein clearance	R-HSA-8964043	6.125351e-01	0.213
Neuronal System	R-HSA-112316	6.144242e-01	0.212
RNA Polymerase II Transcription	R-HSA-73857	6.178219e-01	0.209
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.241697e-01	0.205
Formation of Incision Complex in GG-NER	R-HSA-5696395	6.241697e-01	0.205
Interleukin-2 family signaling	R-HSA-451927	6.241697e-01	0.205
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.267679e-01	0.203
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.283522e-01	0.202
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.283522e-01	0.202
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.283522e-01	0.202
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.283522e-01	0.202
Regulation of NPAS4 gene expression	R-HSA-9768759	6.283522e-01	0.202
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.283522e-01	0.202
Insulin receptor signalling cascade	R-HSA-74751	6.283682e-01	0.202
Potential therapeutics for SARS	R-HSA-9679191	6.302059e-01	0.201
Diseases of programmed cell death	R-HSA-9645723	6.344688e-01	0.198
Hh mutants are degraded by ERAD	R-HSA-5362768	6.355319e-01	0.197
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	6.355319e-01	0.197
Transcriptional Regulation by VENTX	R-HSA-8853884	6.355319e-01	0.197
SARS-CoV-1 Infection	R-HSA-9678108	6.438969e-01	0.191
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.447140e-01	0.191
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.447140e-01	0.191
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.447140e-01	0.191
RNA Polymerase III Transcription Termination	R-HSA-73980	6.447140e-01	0.191
FGFR1 ligand binding and activation	R-HSA-190242	6.447140e-01	0.191
Platelet sensitization by LDL	R-HSA-432142	6.447140e-01	0.191
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.447140e-01	0.191
GAB1 signalosome	R-HSA-180292	6.447140e-01	0.191
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.447140e-01	0.191
Nucleotide-like (purinergic) receptors	R-HSA-418038	6.447140e-01	0.191
Vitamin D (calciferol) metabolism	R-HSA-196791	6.447140e-01	0.191
Circadian clock	R-HSA-9909396	6.540362e-01	0.184
G-protein mediated events	R-HSA-112040	6.554610e-01	0.183
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.574454e-01	0.182
RNA Polymerase I Transcription Initiation	R-HSA-73762	6.574454e-01	0.182
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.574454e-01	0.182
Cleavage of the damaged pyrimidine	R-HSA-110329	6.574454e-01	0.182
Depyrimidination	R-HSA-73928	6.574454e-01	0.182
Phospholipid metabolism	R-HSA-1483257	6.594098e-01	0.181
PPARA activates gene expression	R-HSA-1989781	6.600272e-01	0.180
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.603564e-01	0.180
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.603564e-01	0.180
Germ layer formation at gastrulation	R-HSA-9754189	6.603564e-01	0.180
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.603564e-01	0.180
Regulation of signaling by CBL	R-HSA-912631	6.603564e-01	0.180
Pyrimidine biosynthesis	R-HSA-500753	6.603564e-01	0.180
Specification of the neural plate border	R-HSA-9834899	6.603564e-01	0.180
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	6.603564e-01	0.180
O2/CO2 exchange in erythrocytes	R-HSA-1480926	6.603564e-01	0.180
Other interleukin signaling	R-HSA-449836	6.603564e-01	0.180
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.603564e-01	0.180
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	6.653838e-01	0.177
Organelle biogenesis and maintenance	R-HSA-1852241	6.658888e-01	0.177
Hh mutants abrogate ligand secretion	R-HSA-5387390	6.680006e-01	0.175
TBC/RABGAPs	R-HSA-8854214	6.680006e-01	0.175
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	6.715396e-01	0.173
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.728273e-01	0.172
Late SARS-CoV-2 Infection Events	R-HSA-9772573	6.728273e-01	0.172
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.753110e-01	0.170
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	6.753110e-01	0.170
VxPx cargo-targeting to cilium	R-HSA-5620916	6.753110e-01	0.170
Melanin biosynthesis	R-HSA-5662702	6.753110e-01	0.170
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.753110e-01	0.170
Formation of definitive endoderm	R-HSA-9823730	6.753110e-01	0.170
Synthesis of Ketone Bodies	R-HSA-77111	6.753110e-01	0.170
Eicosanoid ligand-binding receptors	R-HSA-391903	6.753110e-01	0.170
Glycogen synthesis	R-HSA-3322077	6.753110e-01	0.170
Amine ligand-binding receptors	R-HSA-375280	6.782914e-01	0.169
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.811062e-01	0.167
Interleukin-17 signaling	R-HSA-448424	6.811062e-01	0.167
Cyclin E associated events during G1/S transition	R-HSA-69202	6.811062e-01	0.167
Keratinization	R-HSA-6805567	6.866883e-01	0.163
SARS-CoV-2 Infection	R-HSA-9694516	6.878295e-01	0.163
Fanconi Anemia Pathway	R-HSA-6783310	6.883207e-01	0.162
Defective CFTR causes cystic fibrosis	R-HSA-5678895	6.883207e-01	0.162
Somitogenesis	R-HSA-9824272	6.883207e-01	0.162
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	6.883207e-01	0.162
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	6.883207e-01	0.162
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	6.883207e-01	0.162
NoRC negatively regulates rRNA expression	R-HSA-427413	6.893328e-01	0.162
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.893328e-01	0.162
Regulation of mitotic cell cycle	R-HSA-453276	6.893328e-01	0.162
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.896081e-01	0.161
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.896081e-01	0.161
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	6.896081e-01	0.161
Lagging Strand Synthesis	R-HSA-69186	6.896081e-01	0.161
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	6.896081e-01	0.161
Early Phase of HIV Life Cycle	R-HSA-162594	6.896081e-01	0.161
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	6.944662e-01	0.158
Signaling by Hedgehog	R-HSA-5358351	6.965277e-01	0.157
Developmental Lineages of the Mammary Gland	R-HSA-9924644	6.973992e-01	0.157
Transcriptional regulation by small RNAs	R-HSA-5578749	6.973992e-01	0.157
mRNA Splicing - Minor Pathway	R-HSA-72165	6.980914e-01	0.156
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.980914e-01	0.156
Condensation of Prophase Chromosomes	R-HSA-2299718	6.980914e-01	0.156
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	6.980914e-01	0.156
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	6.980914e-01	0.156
Signaling by TGFBR3	R-HSA-9839373	6.980914e-01	0.156
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	6.980914e-01	0.156
Rab regulation of trafficking	R-HSA-9007101	7.009980e-01	0.154
Formation of a pool of free 40S subunits	R-HSA-72689	7.014479e-01	0.154
Eukaryotic Translation Termination	R-HSA-72764	7.014479e-01	0.154
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.032764e-01	0.153
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.032764e-01	0.153
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.032764e-01	0.153
Glutathione synthesis and recycling	R-HSA-174403	7.032764e-01	0.153
Attachment and Entry	R-HSA-9694614	7.032764e-01	0.153
Ribavirin ADME	R-HSA-9755088	7.032764e-01	0.153
Switching of origins to a post-replicative state	R-HSA-69052	7.053058e-01	0.152
Ca2+ pathway	R-HSA-4086398	7.053058e-01	0.152
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.053058e-01	0.152
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.076069e-01	0.150
Synthesis of PC	R-HSA-1483191	7.076069e-01	0.150
COPI-mediated anterograde transport	R-HSA-6807878	7.083140e-01	0.150
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.083140e-01	0.150
Signaling by NOTCH4	R-HSA-9013694	7.130535e-01	0.147
Transcriptional regulation by RUNX2	R-HSA-8878166	7.133309e-01	0.147
Telomere Maintenance	R-HSA-157579	7.150645e-01	0.146
Fructose metabolism	R-HSA-5652084	7.163436e-01	0.145
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	7.163436e-01	0.145
RAF-independent MAPK1/3 activation	R-HSA-112409	7.163436e-01	0.145
NGF-stimulated transcription	R-HSA-9031628	7.168708e-01	0.145
Protein ubiquitination	R-HSA-8852135	7.206431e-01	0.142
Cilium Assembly	R-HSA-5617833	7.221522e-01	0.141
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	7.246634e-01	0.140
Gap junction trafficking and regulation	R-HSA-157858	7.258866e-01	0.139
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	7.258866e-01	0.139
RNA Polymerase I Promoter Clearance	R-HSA-73854	7.280757e-01	0.138
Interleukin receptor SHC signaling	R-HSA-912526	7.288361e-01	0.137
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.288361e-01	0.137
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.288361e-01	0.137
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	7.288361e-01	0.137
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.288361e-01	0.137
Ketone body metabolism	R-HSA-74182	7.288361e-01	0.137
Interferon Signaling	R-HSA-913531	7.291372e-01	0.137
G alpha (q) signalling events	R-HSA-416476	7.301657e-01	0.137
PI3K Cascade	R-HSA-109704	7.346583e-01	0.134
Generic Transcription Pathway	R-HSA-212436	7.402595e-01	0.131
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	7.407792e-01	0.130
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	7.407792e-01	0.130
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	7.407792e-01	0.130
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.407792e-01	0.130
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.407792e-01	0.130
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.407792e-01	0.130
TNFs bind their physiological receptors	R-HSA-5669034	7.407792e-01	0.130
Selenocysteine synthesis	R-HSA-2408557	7.409163e-01	0.130
RNA Polymerase I Transcription	R-HSA-73864	7.424744e-01	0.129
ABC transporter disorders	R-HSA-5619084	7.424744e-01	0.129
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.431899e-01	0.129
Activation of NF-kappaB in B cells	R-HSA-1169091	7.431899e-01	0.129
The phototransduction cascade	R-HSA-2514856	7.431899e-01	0.129
SARS-CoV Infections	R-HSA-9679506	7.463675e-01	0.127
Oxidative Stress Induced Senescence	R-HSA-2559580	7.470938e-01	0.127
C-type lectin receptors (CLRs)	R-HSA-5621481	7.499122e-01	0.125
ER to Golgi Anterograde Transport	R-HSA-199977	7.509265e-01	0.124
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.514855e-01	0.124
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	7.514855e-01	0.124
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.514855e-01	0.124
Uptake and actions of bacterial toxins	R-HSA-5339562	7.514855e-01	0.124
G protein gated Potassium channels	R-HSA-1296059	7.521969e-01	0.124
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.521969e-01	0.124
Activation of G protein gated Potassium channels	R-HSA-1296041	7.521969e-01	0.124
ATP-dependent chromatin remodelers	R-HSA-9932444	7.521969e-01	0.124
SWI/SNF chromatin remodelers	R-HSA-9932451	7.521969e-01	0.124
Formation of the nephric duct	R-HSA-9830364	7.521969e-01	0.124
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.521969e-01	0.124
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.521969e-01	0.124
Laminin interactions	R-HSA-3000157	7.521969e-01	0.124
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.521969e-01	0.124
Viral mRNA Translation	R-HSA-192823	7.531581e-01	0.123
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.562601e-01	0.121
Opioid Signalling	R-HSA-111885	7.591101e-01	0.120
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.595494e-01	0.119
Golgi Associated Vesicle Biogenesis	R-HSA-432722	7.595494e-01	0.119
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.595494e-01	0.119
Nucleotide biosynthesis	R-HSA-8956320	7.595494e-01	0.119
MET activates PTK2 signaling	R-HSA-8874081	7.631124e-01	0.117
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.631124e-01	0.117
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.631124e-01	0.117
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	7.631124e-01	0.117
Metalloprotease DUBs	R-HSA-5689901	7.631124e-01	0.117
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	7.631124e-01	0.117
Suppression of phagosomal maturation	R-HSA-9637687	7.631124e-01	0.117
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.631124e-01	0.117
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	7.673858e-01	0.115
Base-Excision Repair, AP Site Formation	R-HSA-73929	7.673858e-01	0.115
Transmission across Chemical Synapses	R-HSA-112315	7.686220e-01	0.114
Signaling by BMP	R-HSA-201451	7.735477e-01	0.112
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	7.735477e-01	0.112
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	7.735477e-01	0.112
Insulin processing	R-HSA-264876	7.735477e-01	0.112
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.735477e-01	0.112
Maturation of hRSV A proteins	R-HSA-9828806	7.735477e-01	0.112
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.749991e-01	0.111
HDACs deacetylate histones	R-HSA-3214815	7.749991e-01	0.111
Signaling by NOTCH3	R-HSA-9012852	7.749991e-01	0.111
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	7.758157e-01	0.110
Cytoprotection by HMOX1	R-HSA-9707564	7.758157e-01	0.110
Protein localization	R-HSA-9609507	7.799820e-01	0.108
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.818090e-01	0.107
Synthesis of DNA	R-HSA-69239	7.818090e-01	0.107
Gene Silencing by RNA	R-HSA-211000	7.818090e-01	0.107
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.823938e-01	0.107
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.823938e-01	0.107
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.823938e-01	0.107
SARS-CoV-2-host interactions	R-HSA-9705683	7.831617e-01	0.106
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	7.835239e-01	0.106
Formation of the Early Elongation Complex	R-HSA-113418	7.835239e-01	0.106
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.835239e-01	0.106
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.835239e-01	0.106
Pyroptosis	R-HSA-5620971	7.835239e-01	0.106
Stimuli-sensing channels	R-HSA-2672351	7.872108e-01	0.104
Dectin-2 family	R-HSA-5621480	7.895743e-01	0.103
IRS-mediated signalling	R-HSA-112399	7.895743e-01	0.103
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	7.895743e-01	0.103
mRNA Capping	R-HSA-72086	7.930613e-01	0.101
Termination of translesion DNA synthesis	R-HSA-5656169	7.930613e-01	0.101
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	7.930613e-01	0.101
Platelet calcium homeostasis	R-HSA-418360	7.930613e-01	0.101
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.930613e-01	0.101
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	7.930613e-01	0.101
DARPP-32 events	R-HSA-180024	7.930613e-01	0.101
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.940652e-01	0.100
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.940652e-01	0.100
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.965452e-01	0.099
Dual incision in TC-NER	R-HSA-6782135	7.965452e-01	0.099
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.965452e-01	0.099
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.021789e-01	0.096
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.021789e-01	0.096
Neurotransmitter clearance	R-HSA-112311	8.021789e-01	0.096
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.021789e-01	0.096
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.021789e-01	0.096
Cellular response to starvation	R-HSA-9711097	8.021825e-01	0.096
Deadenylation-dependent mRNA decay	R-HSA-429914	8.033109e-01	0.095
Inositol phosphate metabolism	R-HSA-1483249	8.077568e-01	0.093
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.108954e-01	0.091
Cargo concentration in the ER	R-HSA-5694530	8.108954e-01	0.091
Evasion by RSV of host interferon responses	R-HSA-9833109	8.108954e-01	0.091
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.108954e-01	0.091
Molecules associated with elastic fibres	R-HSA-2129379	8.108954e-01	0.091
IRS-related events triggered by IGF1R	R-HSA-2428928	8.162452e-01	0.088
Formation of paraxial mesoderm	R-HSA-9793380	8.162452e-01	0.088
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.162452e-01	0.088
Nucleotide salvage	R-HSA-8956321	8.162452e-01	0.088
Aquaporin-mediated transport	R-HSA-445717	8.162452e-01	0.088
Collagen degradation	R-HSA-1442490	8.162452e-01	0.088
Signaling by Nuclear Receptors	R-HSA-9006931	8.164013e-01	0.088
ER-Phagosome pathway	R-HSA-1236974	8.164547e-01	0.088
Diseases of mitotic cell cycle	R-HSA-9675126	8.192283e-01	0.087
Inwardly rectifying K+ channels	R-HSA-1296065	8.192283e-01	0.087
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.192283e-01	0.087
Base Excision Repair	R-HSA-73884	8.217186e-01	0.085
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.224227e-01	0.085
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	8.271946e-01	0.082
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.271946e-01	0.082
FGFR1 mutant receptor activation	R-HSA-1839124	8.271946e-01	0.082
Negative regulation of FGFR1 signaling	R-HSA-5654726	8.271946e-01	0.082
Cardiogenesis	R-HSA-9733709	8.271946e-01	0.082
Regulation of MECP2 expression and activity	R-HSA-9022692	8.271946e-01	0.082
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.271946e-01	0.082
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.284132e-01	0.082
Role of phospholipids in phagocytosis	R-HSA-2029485	8.311358e-01	0.080
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	8.348102e-01	0.078
Acyl chain remodelling of PC	R-HSA-1482788	8.348102e-01	0.078
Vpu mediated degradation of CD4	R-HSA-180534	8.348102e-01	0.078
Effects of PIP2 hydrolysis	R-HSA-114508	8.348102e-01	0.078
Miscellaneous transport and binding events	R-HSA-5223345	8.348102e-01	0.078
Signaling by Insulin receptor	R-HSA-74752	8.367438e-01	0.077
SLC transporter disorders	R-HSA-5619102	8.377159e-01	0.077
Cellular response to hypoxia	R-HSA-1234174	8.398510e-01	0.076
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.415039e-01	0.075
Assembly of the pre-replicative complex	R-HSA-68867	8.415039e-01	0.075
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.420906e-01	0.075
Dual Incision in GG-NER	R-HSA-5696400	8.420906e-01	0.075
eNOS activation	R-HSA-203615	8.420906e-01	0.075
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.420906e-01	0.075
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.420906e-01	0.075
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.420906e-01	0.075
Hyaluronan metabolism	R-HSA-2142845	8.420906e-01	0.075
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.420906e-01	0.075
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	8.453071e-01	0.073
tRNA modification in the nucleus and cytosol	R-HSA-6782315	8.453071e-01	0.073
Disorders of transmembrane transporters	R-HSA-5619115	8.474501e-01	0.072
Neddylation	R-HSA-8951664	8.478406e-01	0.072
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.490506e-01	0.071
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.490506e-01	0.071
Acyl chain remodelling of PE	R-HSA-1482839	8.490506e-01	0.071
PERK regulates gene expression	R-HSA-381042	8.490506e-01	0.071
Transferrin endocytosis and recycling	R-HSA-917977	8.490506e-01	0.071
Oncogene Induced Senescence	R-HSA-2559585	8.490506e-01	0.071
tRNA processing	R-HSA-72306	8.517698e-01	0.070
G alpha (s) signalling events	R-HSA-418555	8.551236e-01	0.068
FGFR2 mutant receptor activation	R-HSA-1839126	8.557042e-01	0.068
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	8.557156e-01	0.068
Translation	R-HSA-72766	8.587333e-01	0.066
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	8.593610e-01	0.066
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.606766e-01	0.065
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.620650e-01	0.064
SLC-mediated transport of organic cations	R-HSA-549127	8.620650e-01	0.064
Beta-oxidation of very long chain fatty acids	R-HSA-390247	8.620650e-01	0.064
Collagen chain trimerization	R-HSA-8948216	8.620650e-01	0.064
Metabolism of folate and pterines	R-HSA-196757	8.620650e-01	0.064
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.635885e-01	0.064
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.654810e-01	0.063
Regulation of CDH1 Gene Transcription	R-HSA-9764560	8.654810e-01	0.063
Post-translational protein phosphorylation	R-HSA-8957275	8.676104e-01	0.062
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	8.681457e-01	0.061
Elastic fibre formation	R-HSA-1566948	8.681457e-01	0.061
Adaptive Immune System	R-HSA-1280218	8.692965e-01	0.061
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.701331e-01	0.060
Metabolism of cofactors	R-HSA-8978934	8.701331e-01	0.060
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.701331e-01	0.060
Hedgehog 'on' state	R-HSA-5632684	8.701331e-01	0.060
Metabolism of porphyrins	R-HSA-189445	8.701331e-01	0.060
Glycerophospholipid biosynthesis	R-HSA-1483206	8.704221e-01	0.060
Transcriptional Regulation by E2F6	R-HSA-8953750	8.739587e-01	0.059
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.739587e-01	0.059
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.739587e-01	0.059
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.739587e-01	0.059
Hedgehog 'off' state	R-HSA-5610787	8.754304e-01	0.058
Disease	R-HSA-1643685	8.757175e-01	0.058
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	8.777119e-01	0.057
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.795158e-01	0.056
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	8.795158e-01	0.056
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.795158e-01	0.056
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.795158e-01	0.056
Glycogen metabolism	R-HSA-8982491	8.795158e-01	0.056
Mitochondrial tRNA aminoacylation	R-HSA-379726	8.795158e-01	0.056
Nuclear signaling by ERBB4	R-HSA-1251985	8.795158e-01	0.056
Regulation of endogenous retroelements	R-HSA-9842860	8.828383e-01	0.054
Signaling by FGFR in disease	R-HSA-1226099	8.832154e-01	0.054
Signaling by ERBB4	R-HSA-1236394	8.832154e-01	0.054
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.848282e-01	0.053
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.848282e-01	0.053
Maturation of spike protein	R-HSA-9694548	8.848282e-01	0.053
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.848282e-01	0.053
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.872981e-01	0.052
Citric acid cycle (TCA cycle)	R-HSA-71403	8.872981e-01	0.052
Iron uptake and transport	R-HSA-917937	8.872981e-01	0.052
Degradation of CRY and PER proteins	R-HSA-9932298	8.899066e-01	0.051
Degradation of GLI1 by the proteasome	R-HSA-5610780	8.899066e-01	0.051
Signaling by FGFR1 in disease	R-HSA-5655302	8.899066e-01	0.051
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.899066e-01	0.051
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.899066e-01	0.051
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.899066e-01	0.051
Translation of Structural Proteins	R-HSA-9683701	8.899066e-01	0.051
UCH proteinases	R-HSA-5689603	8.912483e-01	0.050
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.932152e-01	0.049
Activation of HOX genes during differentiation	R-HSA-5619507	8.932152e-01	0.049
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.947615e-01	0.048
Cytosolic tRNA aminoacylation	R-HSA-379716	8.947615e-01	0.048
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.965619e-01	0.047
Cholesterol biosynthesis	R-HSA-191273	8.987656e-01	0.046
Platelet homeostasis	R-HSA-418346	8.996675e-01	0.046
Signaling by TGFB family members	R-HSA-9006936	9.018055e-01	0.045
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.023401e-01	0.045
Gap junction trafficking	R-HSA-190828	9.038391e-01	0.044
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.038391e-01	0.044
RMTs methylate histone arginines	R-HSA-3214858	9.038391e-01	0.044
Proteasome assembly	R-HSA-9907900	9.038391e-01	0.044
Antigen processing-Cross presentation	R-HSA-1236975	9.057665e-01	0.043
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.072323e-01	0.042
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.080803e-01	0.042
DNA Replication Pre-Initiation	R-HSA-69002	9.086886e-01	0.042
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.091383e-01	0.041
Selenoamino acid metabolism	R-HSA-2408522	9.116031e-01	0.040
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.121347e-01	0.040
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.121347e-01	0.040
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.122573e-01	0.040
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.123689e-01	0.040
Integration of energy metabolism	R-HSA-163685	9.127332e-01	0.040
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.152044e-01	0.038
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.160105e-01	0.038
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.160105e-01	0.038
Extracellular matrix organization	R-HSA-1474244	9.171683e-01	0.038
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	9.185096e-01	0.037
Metal ion SLC transporters	R-HSA-425410	9.197156e-01	0.036
Plasma lipoprotein remodeling	R-HSA-8963899	9.197156e-01	0.036
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.232574e-01	0.035
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.245587e-01	0.034
GPCR downstream signalling	R-HSA-388396	9.256873e-01	0.034
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.257925e-01	0.033
Signaling by FGFR2 in disease	R-HSA-5655253	9.266432e-01	0.033
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.269441e-01	0.033
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.269665e-01	0.033
Regulation of T cell activation by CD28 family	R-HSA-388841	9.286093e-01	0.032
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.292602e-01	0.032
Chaperonin-mediated protein folding	R-HSA-390466	9.295965e-01	0.032
Pyruvate metabolism	R-HSA-70268	9.295965e-01	0.032
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.305687e-01	0.031
Transport to the Golgi and subsequent modification	R-HSA-948021	9.317891e-01	0.031
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.324348e-01	0.030
Leishmania parasite growth and survival	R-HSA-9664433	9.324348e-01	0.030
FCERI mediated NF-kB activation	R-HSA-2871837	9.328261e-01	0.030
Amino acids regulate mTORC1	R-HSA-9639288	9.359315e-01	0.029
Neurotransmitter release cycle	R-HSA-112310	9.369596e-01	0.028
Downstream TCR signaling	R-HSA-202424	9.369596e-01	0.028
Class B/2 (Secretin family receptors)	R-HSA-373080	9.369596e-01	0.028
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.387588e-01	0.027
Developmental Cell Lineages	R-HSA-9734767	9.392945e-01	0.027
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.417952e-01	0.026
Protein folding	R-HSA-391251	9.435886e-01	0.025
Ion homeostasis	R-HSA-5578775	9.440451e-01	0.025
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.440451e-01	0.025
FCGR activation	R-HSA-2029481	9.456470e-01	0.024
Mitochondrial protein degradation	R-HSA-9837999	9.476338e-01	0.023
DNA Replication	R-HSA-69306	9.486387e-01	0.023
Viral Infection Pathways	R-HSA-9824446	9.497510e-01	0.022
Peptide ligand-binding receptors	R-HSA-375276	9.529195e-01	0.021
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	9.532898e-01	0.021
Glutathione conjugation	R-HSA-156590	9.532898e-01	0.021
Metabolism of polyamines	R-HSA-351202	9.532898e-01	0.021
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.532898e-01	0.021
tRNA Aminoacylation	R-HSA-379724	9.532898e-01	0.021
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	9.532898e-01	0.021
Signaling by GPCR	R-HSA-372790	9.535223e-01	0.021
HCMV Late Events	R-HSA-9610379	9.545060e-01	0.020
Transcriptional regulation by RUNX3	R-HSA-8878159	9.549099e-01	0.020
Signaling by TGF-beta Receptor Complex	R-HSA-170834	9.549099e-01	0.020
Drug ADME	R-HSA-9748784	9.563037e-01	0.019
Ion channel transport	R-HSA-983712	9.567622e-01	0.019
Synthesis of bile acids and bile salts	R-HSA-192105	9.581752e-01	0.019
Ion transport by P-type ATPases	R-HSA-936837	9.610088e-01	0.017
Degradation of the extracellular matrix	R-HSA-1474228	9.622167e-01	0.017
HCMV Early Events	R-HSA-9609690	9.646396e-01	0.016
Kidney development	R-HSA-9830369	9.659498e-01	0.015
Co-inhibition by PD-1	R-HSA-389948	9.685256e-01	0.014
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.702654e-01	0.013
COPII-mediated vesicle transport	R-HSA-204005	9.702654e-01	0.013
Metal ion assimilation from the host	R-HSA-9638482	9.715790e-01	0.013
Purine catabolism	R-HSA-74259	9.728346e-01	0.012
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.728346e-01	0.012
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.734227e-01	0.012
Bile acid and bile salt metabolism	R-HSA-194068	9.734869e-01	0.012
Aspirin ADME	R-HSA-9749641	9.740347e-01	0.011
Diseases of carbohydrate metabolism	R-HSA-5663084	9.740347e-01	0.011
ROS and RNS production in phagocytes	R-HSA-1222556	9.751820e-01	0.011
Interferon alpha/beta signaling	R-HSA-909733	9.797479e-01	0.009
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.802020e-01	0.009
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.802020e-01	0.009
Peptide hormone metabolism	R-HSA-2980736	9.812561e-01	0.008
Amyloid fiber formation	R-HSA-977225	9.819135e-01	0.008
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.822744e-01	0.008
Peroxisomal lipid metabolism	R-HSA-390918	9.842077e-01	0.007
Infectious disease	R-HSA-5663205	9.849251e-01	0.007
Interferon gamma signaling	R-HSA-877300	9.861492e-01	0.006
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.872618e-01	0.006
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.874038e-01	0.006
Metabolism of nucleotides	R-HSA-15869	9.897604e-01	0.004
Cardiac conduction	R-HSA-5576891	9.899705e-01	0.004
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.900126e-01	0.004
Transport of small molecules	R-HSA-382551	9.905087e-01	0.004
Signaling by NOTCH	R-HSA-157118	9.909717e-01	0.004
Scavenging of heme from plasma	R-HSA-2168880	9.916172e-01	0.004
Regulation of insulin secretion	R-HSA-422356	9.926816e-01	0.003
G alpha (i) signalling events	R-HSA-418594	9.928668e-01	0.003
HCMV Infection	R-HSA-9609646	9.934322e-01	0.003
RSV-host interactions	R-HSA-9833110	9.946695e-01	0.002
Visual phototransduction	R-HSA-2187338	9.950938e-01	0.002
Bacterial Infection Pathways	R-HSA-9824439	9.951092e-01	0.002
Gastrulation	R-HSA-9758941	9.954715e-01	0.002
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.956495e-01	0.002
Antimicrobial peptides	R-HSA-6803157	9.961179e-01	0.002
Cell surface interactions at the vascular wall	R-HSA-202733	9.969397e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.981376e-01	0.001
SLC-mediated transmembrane transport	R-HSA-425407	9.984356e-01	0.001
Nucleotide catabolism	R-HSA-8956319	9.985017e-01	0.001
Diseases of glycosylation	R-HSA-3781865	9.989494e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.992744e-01	0.000
Post-translational protein modification	R-HSA-597592	9.993154e-01	0.000
GPCR ligand binding	R-HSA-500792	9.993363e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.997647e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999320e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.999453e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999527e-01	0.000
Infection with Enterobacteria	R-HSA-9640148	9.999568e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999880e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999920e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999955e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999962e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999987e-01	0.000
Metabolism of proteins	R-HSA-392499	9.999988e-01	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	3.642642e-13	12.439
Axon guidance	R-HSA-422475	4.778955e-12	11.321
L1CAM interactions	R-HSA-373760	3.994183e-11	10.399
Nervous system development	R-HSA-9675108	8.043632e-11	10.095
Cell Cycle, Mitotic	R-HSA-69278	1.539315e-10	9.813
Recycling pathway of L1	R-HSA-437239	2.574538e-10	9.589
Cellular responses to stress	R-HSA-2262752	3.459081e-10	9.461
HSF1-dependent transactivation	R-HSA-3371571	8.048823e-10	9.094
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	7.691722e-10	9.114
Signaling by RAS mutants	R-HSA-6802949	1.313292e-09	8.882
Signaling downstream of RAS mutants	R-HSA-9649948	1.313292e-09	8.882
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.313292e-09	8.882
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.313292e-09	8.882
Cellular response to heat stress	R-HSA-3371556	1.807015e-09	8.743
Signaling by RAF1 mutants	R-HSA-9656223	2.090604e-09	8.680
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.060446e-09	8.296
M Phase	R-HSA-68886	6.158588e-09	8.211
Cellular responses to stimuli	R-HSA-8953897	9.864603e-09	8.006
Oncogenic MAPK signaling	R-HSA-6802957	4.702430e-08	7.328
Attenuation phase	R-HSA-3371568	5.333821e-08	7.273
Apoptosis	R-HSA-109581	6.009570e-08	7.221
Post NMDA receptor activation events	R-HSA-438064	7.918305e-08	7.101
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.054375e-08	7.043
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.525402e-07	6.817
Signal Transduction	R-HSA-162582	1.675770e-07	6.776
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	2.507908e-07	6.601
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.777863e-07	6.556
Apoptotic execution phase	R-HSA-75153	3.060276e-07	6.514
MAP2K and MAPK activation	R-HSA-5674135	5.421473e-07	6.266
Metabolism of RNA	R-HSA-8953854	1.291774e-06	5.889
Programmed Cell Death	R-HSA-5357801	1.972201e-06	5.705
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.299015e-06	5.638
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.636522e-06	5.579
Cell Cycle Checkpoints	R-HSA-69620	3.184795e-06	5.497
HSF1 activation	R-HSA-3371511	4.362659e-06	5.360
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	4.349585e-06	5.362
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.402612e-06	5.356
Mitotic Prometaphase	R-HSA-68877	4.782081e-06	5.320
Mitotic Anaphase	R-HSA-68882	5.061288e-06	5.296
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.495210e-06	5.260
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.781915e-06	5.010
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	9.781915e-06	5.010
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.362424e-05	4.866
Interleukin-12 signaling	R-HSA-9020591	1.470913e-05	4.832
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.733496e-05	4.761
Separation of Sister Chromatids	R-HSA-2467813	1.975603e-05	4.704
Developmental Biology	R-HSA-1266738	2.731127e-05	4.564
Cellular Senescence	R-HSA-2559583	3.115034e-05	4.507
G2/M Checkpoints	R-HSA-69481	3.175419e-05	4.498
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.396979e-05	4.469
MAPK family signaling cascades	R-HSA-5683057	3.995347e-05	4.398
Mitotic Prophase	R-HSA-68875	4.284013e-05	4.368
Apoptotic cleavage of cellular proteins	R-HSA-111465	4.384390e-05	4.358
Regulation of CDH1 Function	R-HSA-9764561	5.599333e-05	4.252
Striated Muscle Contraction	R-HSA-390522	6.673558e-05	4.176
Interleukin-12 family signaling	R-HSA-447115	7.022879e-05	4.153
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.720725e-05	4.112
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.025231e-05	4.096
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.129560e-04	3.947
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.129560e-04	3.947
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.152431e-04	3.938
RAF/MAP kinase cascade	R-HSA-5673001	1.397758e-04	3.855
Cell-Cell communication	R-HSA-1500931	1.420841e-04	3.847
Cell junction organization	R-HSA-446728	1.592958e-04	3.798
Signaling by Hippo	R-HSA-2028269	1.957509e-04	3.708
MAPK1/MAPK3 signaling	R-HSA-5684996	2.081205e-04	3.682
mRNA Splicing - Major Pathway	R-HSA-72163	2.242705e-04	3.649
Aggrephagy	R-HSA-9646399	2.420659e-04	3.616
Cytokine Signaling in Immune system	R-HSA-1280215	2.437404e-04	3.613
Nuclear Receptor transcription pathway	R-HSA-383280	2.461273e-04	3.609
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.577411e-04	3.589
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.577743e-04	3.589
Signaling by ALK in cancer	R-HSA-9700206	2.577743e-04	3.589
Regulation of MECP2 expression and activity	R-HSA-9022692	2.732541e-04	3.563
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.826282e-04	3.549
Long-term potentiation	R-HSA-9620244	2.844507e-04	3.546
Gene expression (Transcription)	R-HSA-74160	3.039150e-04	3.517
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.110769e-04	3.507
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.291131e-04	3.483
Muscle contraction	R-HSA-397014	3.395622e-04	3.469
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.877234e-04	3.411
RAF activation	R-HSA-5673000	3.910697e-04	3.408
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.107520e-04	3.386
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.189970e-04	3.378
EPH-Ephrin signaling	R-HSA-2682334	4.322301e-04	3.364
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.454198e-04	3.351
mRNA Splicing	R-HSA-72172	4.639260e-04	3.334
Signalling to ERKs	R-HSA-187687	4.640533e-04	3.333
G2/M DNA damage checkpoint	R-HSA-69473	5.154593e-04	3.288
Cell-extracellular matrix interactions	R-HSA-446353	5.779702e-04	3.238
Chromatin modifying enzymes	R-HSA-3247509	5.829046e-04	3.234
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.265991e-04	3.203
Chromatin organization	R-HSA-4839726	6.395362e-04	3.194
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.113942e-04	3.148
Prolonged ERK activation events	R-HSA-169893	7.525424e-04	3.123
RNA Polymerase II Transcription	R-HSA-73857	7.754596e-04	3.110
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	7.935804e-04	3.100
Selective autophagy	R-HSA-9663891	7.900280e-04	3.102
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.579232e-04	3.120
Transcriptional Regulation by TP53	R-HSA-3700989	8.036480e-04	3.095
Activation of BH3-only proteins	R-HSA-114452	7.502970e-04	3.125
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.058739e-04	3.094
Transcriptional Regulation by E2F6	R-HSA-8953750	8.765240e-04	3.057
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.929127e-04	3.049
Negative feedback regulation of MAPK pathway	R-HSA-5674499	9.219430e-04	3.035
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	9.742693e-04	3.011
Diseases of mitotic cell cycle	R-HSA-9675126	1.056478e-03	2.976
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	9.902468e-04	3.004
Gap junction trafficking and regulation	R-HSA-157858	1.050546e-03	2.979
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.192259e-03	2.924
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.200811e-03	2.921
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.221469e-03	2.913
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.313902e-03	2.881
Chaperone Mediated Autophagy	R-HSA-9613829	1.526660e-03	2.816
Switching of origins to a post-replicative state	R-HSA-69052	1.466319e-03	2.834
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.526660e-03	2.816
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.443747e-03	2.841
Transport of connexons to the plasma membrane	R-HSA-190872	1.526660e-03	2.816
Cell-cell junction organization	R-HSA-421270	1.472900e-03	2.832
MTOR signalling	R-HSA-165159	1.546996e-03	2.811
Estrogen-dependent gene expression	R-HSA-9018519	1.564025e-03	2.806
S Phase	R-HSA-69242	1.600878e-03	2.796
Signaling by NTRKs	R-HSA-166520	1.600878e-03	2.796
G2/M Transition	R-HSA-69275	1.602623e-03	2.795
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.654700e-03	2.781
Smooth Muscle Contraction	R-HSA-445355	1.722456e-03	2.764
Synthesis of DNA	R-HSA-69239	1.955264e-03	2.709
Generic Transcription Pathway	R-HSA-212436	1.876871e-03	2.727
Mitotic G2-G2/M phases	R-HSA-453274	1.802746e-03	2.744
Gap junction trafficking	R-HSA-190828	2.010355e-03	2.697
Interaction between L1 and Ankyrins	R-HSA-445095	2.048014e-03	2.689
Uptake and function of diphtheria toxin	R-HSA-5336415	2.073144e-03	2.683
Frs2-mediated activation	R-HSA-170968	2.239466e-03	2.650
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.239466e-03	2.650
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	2.267460e-03	2.644
Signal transduction by L1	R-HSA-445144	2.307468e-03	2.637
Post-chaperonin tubulin folding pathway	R-HSA-389977	2.307468e-03	2.637
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.414492e-03	2.617
RSK activation	R-HSA-444257	2.913353e-03	2.536
Mitotic Spindle Checkpoint	R-HSA-69618	2.702435e-03	2.568
ESR-mediated signaling	R-HSA-8939211	2.934431e-03	2.532
Nuclear Envelope Breakdown	R-HSA-2980766	2.706113e-03	2.568
Autophagy	R-HSA-9612973	2.674279e-03	2.573
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.913353e-03	2.536
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.297011e-03	2.482
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.418148e-03	2.466
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.534919e-03	2.452
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.534919e-03	2.452
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.587479e-03	2.445
Signaling by VEGF	R-HSA-194138	3.645431e-03	2.438
Assembly of the pre-replicative complex	R-HSA-68867	3.741029e-03	2.427
Trafficking of AMPA receptors	R-HSA-399719	3.821261e-03	2.418
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.821261e-03	2.418
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.953635e-03	2.403
mTORC1-mediated signalling	R-HSA-166208	3.997460e-03	2.398
Signaling by ROBO receptors	R-HSA-376176	4.096461e-03	2.388
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.104129e-03	2.387
Signaling by MAP2K mutants	R-HSA-9652169	4.104129e-03	2.387
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	4.443980e-03	2.352
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	4.724772e-03	2.326
PKMTs methylate histone lysines	R-HSA-3214841	4.368156e-03	2.360
SARS-CoV-1-host interactions	R-HSA-9692914	4.584820e-03	2.339
Signaling by Interleukins	R-HSA-449147	4.794804e-03	2.319
Negative regulation of MAPK pathway	R-HSA-5675221	4.926048e-03	2.308
DNA Replication	R-HSA-69306	4.927800e-03	2.307
Macroautophagy	R-HSA-1632852	5.012787e-03	2.300
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.056908e-03	2.296
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	5.131366e-03	2.290
Apoptosis induced DNA fragmentation	R-HSA-140342	5.237014e-03	2.281
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	5.237014e-03	2.281
Chaperonin-mediated protein folding	R-HSA-390466	5.617399e-03	2.250
DNA Replication Pre-Initiation	R-HSA-69002	5.663939e-03	2.247
Interferon Signaling	R-HSA-913531	5.701209e-03	2.244
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	5.800377e-03	2.237
NrCAM interactions	R-HSA-447038	6.270791e-03	2.203
AURKA Activation by TPX2	R-HSA-8854518	6.561901e-03	2.183
HIV Infection	R-HSA-162906	6.944642e-03	2.158
MITF-M-regulated melanocyte development	R-HSA-9730414	7.019688e-03	2.154
DAG and IP3 signaling	R-HSA-1489509	7.718686e-03	2.112
Protein folding	R-HSA-391251	8.815253e-03	2.055
Oxidative Stress Induced Senescence	R-HSA-2559580	7.839981e-03	2.106
Adherens junctions interactions	R-HSA-418990	8.823771e-03	2.054
PKR-mediated signaling	R-HSA-9833482	7.811756e-03	2.107
Membrane Trafficking	R-HSA-199991	8.966991e-03	2.047
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	9.007528e-03	2.045
Noncanonical activation of NOTCH3	R-HSA-9017802	9.007528e-03	2.045
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	9.007528e-03	2.045
Viral Infection Pathways	R-HSA-9824446	9.185672e-03	2.037
Rap1 signalling	R-HSA-392517	9.340138e-03	2.030
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.005186e-02	1.998
RUNX3 regulates p14-ARF	R-HSA-8951936	1.063610e-02	1.973
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.063610e-02	1.973
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.063610e-02	1.973
Regulation of PTEN gene transcription	R-HSA-8943724	1.090493e-02	1.962
Manipulation of host energy metabolism	R-HSA-9636667	1.115382e-02	1.953
Activation of the pre-replicative complex	R-HSA-68962	1.278007e-02	1.893
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.278007e-02	1.893
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.180491e-02	1.928
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.238584e-02	1.907
Breakdown of the nuclear lamina	R-HSA-352238	1.115382e-02	1.953
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.178746e-02	1.929
CREB phosphorylation	R-HSA-199920	1.234291e-02	1.909
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.313481e-02	1.882
Nuclear signaling by ERBB4	R-HSA-1251985	1.313481e-02	1.882
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.405594e-02	1.852
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.405594e-02	1.852
Semaphorin interactions	R-HSA-373755	1.405594e-02	1.852
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.483934e-02	1.829
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.485369e-02	1.828
Ion transport by P-type ATPases	R-HSA-936837	1.524243e-02	1.817
Orc1 removal from chromatin	R-HSA-68949	1.525428e-02	1.817
mRNA 3'-end processing	R-HSA-72187	1.525428e-02	1.817
Uptake and actions of bacterial toxins	R-HSA-5339562	1.525428e-02	1.817
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.915913e-02	1.718
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.915913e-02	1.718
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.915913e-02	1.718
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.915913e-02	1.718
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.915913e-02	1.718
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.915913e-02	1.718
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.915913e-02	1.718
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.915913e-02	1.718
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.915913e-02	1.718
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.915913e-02	1.718
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.915913e-02	1.718
SOS-mediated signalling	R-HSA-112412	1.629640e-02	1.788
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.665639e-02	1.778
Regulation of endogenous retroelements	R-HSA-9842860	1.817566e-02	1.741
Transcriptional Regulation by MECP2	R-HSA-8986944	1.842685e-02	1.735
DNA strand elongation	R-HSA-69190	1.622260e-02	1.790
RUNX3 regulates WNT signaling	R-HSA-8951430	1.629640e-02	1.788
Epigenetic regulation of gene expression	R-HSA-212165	1.626596e-02	1.789
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.776605e-02	1.750
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.816320e-02	1.741
Activation of ATR in response to replication stress	R-HSA-176187	1.816320e-02	1.741
Ca-dependent events	R-HSA-111996	1.776605e-02	1.750
Intracellular signaling by second messengers	R-HSA-9006925	1.830942e-02	1.737
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.816320e-02	1.741
HDACs deacetylate histones	R-HSA-3214815	1.973511e-02	1.705
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.981757e-02	1.703
Formation of annular gap junctions	R-HSA-196025	2.087945e-02	1.680
Signaling by EGFR	R-HSA-177929	2.141746e-02	1.669
Ion homeostasis	R-HSA-5578775	2.141746e-02	1.669
Phosphorylation of the APC/C	R-HSA-176412	2.209243e-02	1.656
Cap-dependent Translation Initiation	R-HSA-72737	2.211177e-02	1.655
Eukaryotic Translation Initiation	R-HSA-72613	2.211177e-02	1.655
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.216965e-02	1.654
Neurodegenerative Diseases	R-HSA-8863678	2.216965e-02	1.654
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.216965e-02	1.654
Gap junction assembly	R-HSA-190861	2.250877e-02	1.648
Transcriptional regulation by RUNX1	R-HSA-8878171	2.253221e-02	1.647
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.395516e-02	1.621
Tight junction interactions	R-HSA-420029	2.505370e-02	1.601
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	2.892930e-02	1.539
Gap junction degradation	R-HSA-190873	2.609648e-02	1.583
Disorders of Developmental Biology	R-HSA-9675151	2.579569e-02	1.588
Condensation of Prophase Chromosomes	R-HSA-2299718	2.558144e-02	1.592
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.558144e-02	1.592
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	2.785168e-02	1.555
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.025478e-02	1.519
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.943531e-02	1.531
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.943531e-02	1.531
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.904214e-02	1.537
Amplification of signal from the kinetochores	R-HSA-141424	2.904214e-02	1.537
Transcriptional regulation by RUNX3	R-HSA-8878159	2.988338e-02	1.525
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.025618e-02	1.519
Clathrin-mediated endocytosis	R-HSA-8856828	2.556557e-02	1.592
Signaling by ERBB2	R-HSA-1227986	2.916296e-02	1.535
GP1b-IX-V activation signalling	R-HSA-430116	2.609648e-02	1.583
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.984999e-02	1.525
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.562584e-02	1.591
HIV Life Cycle	R-HSA-162587	2.512386e-02	1.600
Protein-protein interactions at synapses	R-HSA-6794362	2.729589e-02	1.564
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.609648e-02	1.583
Unwinding of DNA	R-HSA-176974	2.609648e-02	1.583
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.579569e-02	1.588
RNA Polymerase II Transcription Termination	R-HSA-73856	3.136584e-02	1.504
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.025478e-02	1.519
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	2.609648e-02	1.583
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.579569e-02	1.588
Transmission across Chemical Synapses	R-HSA-112315	2.682238e-02	1.572
PLC beta mediated events	R-HSA-112043	3.136584e-02	1.504
Calmodulin induced events	R-HSA-111933	2.750432e-02	1.561
CaM pathway	R-HSA-111997	2.750432e-02	1.561
XBP1(S) activates chaperone genes	R-HSA-381038	3.086618e-02	1.511
Signaling by NOTCH4	R-HSA-9013694	3.144216e-02	1.502
Signaling by ERBB4	R-HSA-1236394	3.144216e-02	1.502
EPHA-mediated growth cone collapse	R-HSA-3928663	3.151694e-02	1.501
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	3.151694e-02	1.501
EGFR Transactivation by Gastrin	R-HSA-2179392	3.194583e-02	1.496
Signal attenuation	R-HSA-74749	3.194583e-02	1.496
Host Interactions of HIV factors	R-HSA-162909	3.329400e-02	1.478
p75 NTR receptor-mediated signalling	R-HSA-193704	3.340382e-02	1.476
Centrosome maturation	R-HSA-380287	3.354218e-02	1.474
ISG15 antiviral mechanism	R-HSA-1169408	3.354218e-02	1.474
Non-integrin membrane-ECM interactions	R-HSA-3000171	3.354218e-02	1.474
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.425987e-02	1.465
Ephrin signaling	R-HSA-3928664	3.425987e-02	1.465
HIV elongation arrest and recovery	R-HSA-167287	3.510505e-02	1.455
Pausing and recovery of HIV elongation	R-HSA-167290	3.510505e-02	1.455
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.654314e-02	1.437
G1/S Transition	R-HSA-69206	3.663156e-02	1.436
Extra-nuclear estrogen signaling	R-HSA-9009391	3.720798e-02	1.429
HCMV Early Events	R-HSA-9609690	3.836113e-02	1.416
ChREBP activates metabolic gene expression	R-HSA-163765	3.842049e-02	1.415
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.897024e-02	1.409
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.902815e-02	1.409
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.956945e-02	1.403
DNA Double-Strand Break Repair	R-HSA-5693532	3.975121e-02	1.401
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	4.026338e-02	1.395
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.026338e-02	1.395
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.026338e-02	1.395
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.026338e-02	1.395
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	5.112321e-02	1.291
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.297632e-02	1.276
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.297632e-02	1.276
IRS activation	R-HSA-74713	5.297632e-02	1.276
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	5.297632e-02	1.276
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.297632e-02	1.276
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.319569e-02	1.274
Pervasive developmental disorders	R-HSA-9005895	5.319569e-02	1.274
Disorders of Nervous System Development	R-HSA-9697154	5.319569e-02	1.274
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.964301e-02	1.304
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	4.124889e-02	1.385
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	4.435432e-02	1.353
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.435432e-02	1.353
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	5.100644e-02	1.292
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.455590e-02	1.263
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.455590e-02	1.263
Transcription of the HIV genome	R-HSA-167172	5.000679e-02	1.301
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.301109e-02	1.366
EGFR downregulation	R-HSA-182971	4.733358e-02	1.325
Neurexins and neuroligins	R-HSA-6794361	4.124889e-02	1.385
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	5.455590e-02	1.263
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.303577e-02	1.366
ERK/MAPK targets	R-HSA-198753	4.964301e-02	1.304
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.435432e-02	1.353
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.297632e-02	1.276
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.346679e-02	1.362
Developmental Cell Lineages	R-HSA-9734767	4.724616e-02	1.326
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.550893e-02	1.342
TBC/RABGAPs	R-HSA-8854214	5.454907e-02	1.263
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	4.760633e-02	1.322
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.098546e-02	1.293
Early Phase of HIV Life Cycle	R-HSA-162594	4.964301e-02	1.304
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.303577e-02	1.366
Homology Directed Repair	R-HSA-5693538	4.938155e-02	1.306
Activation of RAC1	R-HSA-428540	4.550893e-02	1.342
Transcriptional Regulation by VENTX	R-HSA-8853884	4.303577e-02	1.366
G-protein mediated events	R-HSA-112040	4.698651e-02	1.328
SARS-CoV-2-host interactions	R-HSA-9705683	4.177989e-02	1.379
Nephrin family interactions	R-HSA-373753	4.415600e-02	1.355
IRE1alpha activates chaperones	R-HSA-381070	4.352630e-02	1.361
SARS-CoV-1 Infection	R-HSA-9678108	5.417369e-02	1.266
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.544017e-02	1.256
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.548728e-02	1.256
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	5.548728e-02	1.256
Signaling by PDGFR in disease	R-HSA-9671555	5.548728e-02	1.256
Interleukin-17 signaling	R-HSA-448424	5.641709e-02	1.249
Chromosome Maintenance	R-HSA-73886	5.646003e-02	1.248
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.646003e-02	1.248
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.672353e-02	1.246
Transport of the SLBP independent Mature mRNA	R-HSA-159227	5.672353e-02	1.246
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.689120e-02	1.245
COPI-mediated anterograde transport	R-HSA-6807878	5.932220e-02	1.227
Regulation of mitotic cell cycle	R-HSA-453276	5.980910e-02	1.223
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.980910e-02	1.223
MAPK6/MAPK4 signaling	R-HSA-5687128	6.000302e-02	1.222
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	6.146204e-02	1.211
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	6.146204e-02	1.211
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	6.146204e-02	1.211
MHC class II antigen presentation	R-HSA-2132295	6.153944e-02	1.211
FGFR2 alternative splicing	R-HSA-6803529	6.168551e-02	1.210
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.168551e-02	1.210
DNA Damage Recognition in GG-NER	R-HSA-5696394	6.179131e-02	1.209
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	6.179131e-02	1.209
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.210686e-02	1.207
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	6.210686e-02	1.207
Nucleosome assembly	R-HSA-774815	6.316500e-02	1.200
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.316500e-02	1.200
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.332676e-02	1.198
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.332676e-02	1.198
Potential therapeutics for SARS	R-HSA-9679191	6.393284e-02	1.194
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.710672e-02	1.173
Nuclear import of Rev protein	R-HSA-180746	6.710672e-02	1.173
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.823309e-02	1.166
Kinesins	R-HSA-983189	7.026468e-02	1.153
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	7.028649e-02	1.153
NRIF signals cell death from the nucleus	R-HSA-205043	7.028649e-02	1.153
RNA Polymerase II Pre-transcription Events	R-HSA-674695	7.074127e-02	1.150
Neutrophil degranulation	R-HSA-6798695	7.082070e-02	1.150
Glycolysis	R-HSA-70171	7.169493e-02	1.145
Unfolded Protein Response (UPR)	R-HSA-381119	7.219423e-02	1.141
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.253712e-02	1.139
Diseases of programmed cell death	R-HSA-9645723	7.352585e-02	1.134
Death Receptor Signaling	R-HSA-73887	7.406395e-02	1.130
MAP kinase activation	R-HSA-450294	7.457183e-02	1.127
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.463885e-02	1.127
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	7.512418e-02	1.124
Deadenylation of mRNA	R-HSA-429947	7.512418e-02	1.124
Diseases of Telomere Maintenance	R-HSA-9673013	9.963578e-02	1.002
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	9.963578e-02	1.002
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	9.963578e-02	1.002
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	9.963578e-02	1.002
TICAM1 deficiency - HSE	R-HSA-5602566	9.963578e-02	1.002
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	9.963578e-02	1.002
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	9.963578e-02	1.002
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	9.963578e-02	1.002
Signaling by LTK in cancer	R-HSA-9842640	8.187153e-02	1.087
MECP2 regulates transcription factors	R-HSA-9022707	9.775363e-02	1.010
IFNG signaling activates MAPKs	R-HSA-9732724	9.775363e-02	1.010
Cohesin Loading onto Chromatin	R-HSA-2470946	9.775363e-02	1.010
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	9.775363e-02	1.010
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.144124e-01	0.942
Signaling by MRAS-complex mutants	R-HSA-9660537	1.144124e-01	0.942
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.144124e-01	0.942
Processive synthesis on the lagging strand	R-HSA-69183	7.964529e-02	1.099
Processing of Intronless Pre-mRNAs	R-HSA-77595	9.986222e-02	1.001
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.106652e-01	0.956
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.106652e-01	0.956
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.990795e-02	1.046
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	9.778369e-02	1.010
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	9.778369e-02	1.010
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.452062e-02	1.073
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.040732e-01	0.983
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.040732e-01	0.983
Formation of RNA Pol II elongation complex	R-HSA-112382	9.923896e-02	1.003
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.051275e-01	0.978
Translation initiation complex formation	R-HSA-72649	1.111934e-01	0.954
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.089421e-01	0.963
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.990795e-02	1.046
Nucleotide Excision Repair	R-HSA-5696398	9.309638e-02	1.031
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.144540e-01	0.941
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	1.144124e-01	0.942
p38MAPK events	R-HSA-171007	7.964529e-02	1.099
RNA Polymerase I Transcription	R-HSA-73864	8.709388e-02	1.060
RNA Polymerase I Promoter Clearance	R-HSA-73854	7.866353e-02	1.104
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.110469e-01	0.954
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.050813e-01	0.978
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	9.986222e-02	1.001
Signaling by Nuclear Receptors	R-HSA-9006931	7.879013e-02	1.104
VEGFR2 mediated cell proliferation	R-HSA-5218921	8.235180e-02	1.084
PCP/CE pathway	R-HSA-4086400	8.709388e-02	1.060
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	8.452062e-02	1.073
Formation of editosomes by ADAR proteins	R-HSA-77042	9.963578e-02	1.002
Phase 0 - rapid depolarisation	R-HSA-5576892	1.059692e-01	0.975
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.144540e-01	0.941
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.040732e-01	0.983
Interactions of Rev with host cellular proteins	R-HSA-177243	1.040732e-01	0.983
CHL1 interactions	R-HSA-447041	9.775363e-02	1.010
Degradation of CDH1	R-HSA-9766229	8.266197e-02	1.083
Vesicle-mediated transport	R-HSA-5653656	1.085587e-01	0.964
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.903102e-02	1.102
Cilium Assembly	R-HSA-5617833	8.947697e-02	1.048
TGFBR3 PTM regulation	R-HSA-9839383	1.144124e-01	0.942
Protein methylation	R-HSA-8876725	7.964529e-02	1.099
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.990795e-02	1.046
Neuronal System	R-HSA-112316	8.880377e-02	1.052
Signaling by NOTCH	R-HSA-157118	9.683305e-02	1.014
Displacement of DNA glycosylase by APEX1	R-HSA-110357	9.775363e-02	1.010
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	9.775363e-02	1.010
Gluconeogenesis	R-HSA-70263	7.750590e-02	1.111
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	9.188329e-02	1.037
Regulation of TP53 Activity	R-HSA-5633007	9.113006e-02	1.040
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.144124e-01	0.942
Influenza Infection	R-HSA-168255	1.040128e-01	0.983
Uptake and function of anthrax toxins	R-HSA-5210891	1.106652e-01	0.956
Regulation of gene expression in beta cells	R-HSA-210745	1.144540e-01	0.941
SARS-CoV Infections	R-HSA-9679506	9.213168e-02	1.036
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.174337e-01	0.930
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.200855e-01	0.921
Synaptic adhesion-like molecules	R-HSA-8849932	1.218930e-01	0.914
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.223756e-01	0.912
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.223756e-01	0.912
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.232267e-01	0.909
Downregulation of ERBB2 signaling	R-HSA-8863795	1.232267e-01	0.909
Ribosomal scanning and start codon recognition	R-HSA-72702	1.238451e-01	0.907
NRAGE signals death through JNK	R-HSA-193648	1.238451e-01	0.907
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.238451e-01	0.907
PTEN Regulation	R-HSA-6807070	1.247626e-01	0.904
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.256477e-01	0.901
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.258693e-01	0.900
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.283155e-01	0.892
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.288054e-01	0.890
Cellular response to chemical stress	R-HSA-9711123	1.291421e-01	0.889
FOXO-mediated transcription	R-HSA-9614085	1.294290e-01	0.888
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.304242e-01	0.885
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.315753e-01	0.881
ARMS-mediated activation	R-HSA-170984	1.317271e-01	0.880
Lipophagy	R-HSA-9613354	1.317271e-01	0.880
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	1.317271e-01	0.880
MAPK1 (ERK2) activation	R-HSA-112411	1.317271e-01	0.880
ALK mutants bind TKIs	R-HSA-9700645	1.317271e-01	0.880
Calcineurin activates NFAT	R-HSA-2025928	1.317271e-01	0.880
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	1.317271e-01	0.880
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	1.317271e-01	0.880
Cellular response to mitochondrial stress	R-HSA-9840373	1.317271e-01	0.880
Inactivation of CDC42 and RAC1	R-HSA-428543	1.317271e-01	0.880
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.317271e-01	0.880
Respiratory syncytial virus genome replication	R-HSA-9834752	1.317271e-01	0.880
Regulated proteolysis of p75NTR	R-HSA-193692	1.317271e-01	0.880
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.322756e-01	0.879
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.322756e-01	0.879
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.322756e-01	0.879
E2F mediated regulation of DNA replication	R-HSA-113510	1.335162e-01	0.874
Hedgehog 'off' state	R-HSA-5610787	1.344681e-01	0.871
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.347018e-01	0.871
Interactions of Tat with host cellular proteins	R-HSA-176034	1.456709e-01	0.837
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	1.456709e-01	0.837
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	1.456709e-01	0.837
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	1.456709e-01	0.837
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.456709e-01	0.837
TRAF3 deficiency - HSE	R-HSA-5602571	1.456709e-01	0.837
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	1.456709e-01	0.837
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.893548e-01	0.723
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	1.893548e-01	0.723
Signaling by RAS GAP mutants	R-HSA-9753510	1.893548e-01	0.723
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.308077e-01	0.637
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.308077e-01	0.637
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	2.308077e-01	0.637
IRAK4 deficiency (TLR5)	R-HSA-5603037	2.308077e-01	0.637
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.308077e-01	0.637
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.308077e-01	0.637
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	2.701431e-01	0.568
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.701431e-01	0.568
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.701431e-01	0.568
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.701431e-01	0.568
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.701431e-01	0.568
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.495875e-01	0.825
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.495875e-01	0.825
2-LTR circle formation	R-HSA-164843	1.495875e-01	0.825
Folding of actin by CCT/TriC	R-HSA-390450	1.495875e-01	0.825
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	1.495875e-01	0.825
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.865502e-01	0.729
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.865502e-01	0.729
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.865502e-01	0.729
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	1.865502e-01	0.729
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.054769e-01	0.687
Polymerase switching	R-HSA-69091	2.054769e-01	0.687
Leading Strand Synthesis	R-HSA-69109	2.054769e-01	0.687
Scavenging by Class F Receptors	R-HSA-3000484	2.054769e-01	0.687
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	2.245963e-01	0.649
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.578301e-01	0.802
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.578301e-01	0.802
Lagging Strand Synthesis	R-HSA-69186	1.578301e-01	0.802
Removal of the Flap Intermediate	R-HSA-69166	2.438395e-01	0.613
Retrograde neurotrophin signalling	R-HSA-177504	2.438395e-01	0.613
RAF-independent MAPK1/3 activation	R-HSA-112409	1.833702e-01	0.737
Erythropoietin activates RAS	R-HSA-9027284	2.631438e-01	0.580
SHC1 events in EGFR signaling	R-HSA-180336	2.631438e-01	0.580
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	1.965273e-01	0.707
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	1.965273e-01	0.707
IPs transport between nucleus and cytosol	R-HSA-1855170	1.511522e-01	0.821
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.609539e-01	0.793
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.709802e-01	0.767
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.812174e-01	0.742
Signaling by EGFR in Cancer	R-HSA-1643713	2.372098e-01	0.625
mRNA Splicing - Minor Pathway	R-HSA-72165	1.572896e-01	0.803
RNA Polymerase I Transcription Termination	R-HSA-73863	2.510849e-01	0.600
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.511288e-01	0.821
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.239978e-01	0.650
HIV Transcription Elongation	R-HSA-167169	2.350813e-01	0.629
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.350813e-01	0.629
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	2.350813e-01	0.629
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	2.099931e-01	0.678
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	2.576177e-01	0.589
HIV Transcription Initiation	R-HSA-167161	2.576177e-01	0.589
RNA Polymerase II Transcription Initiation	R-HSA-75953	2.576177e-01	0.589
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.658935e-01	0.780
Peptide chain elongation	R-HSA-156902	2.506882e-01	0.601
Formation of definitive endoderm	R-HSA-9823730	1.455051e-01	0.837
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.865502e-01	0.729
Integration of provirus	R-HSA-162592	1.865502e-01	0.729
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.976752e-01	0.704
Regulation of the apoptosome activity	R-HSA-9627069	1.495875e-01	0.825
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.865502e-01	0.729
Regulation of CDH11 function	R-HSA-9762292	1.495875e-01	0.825
Formation of apoptosome	R-HSA-111458	1.495875e-01	0.825
PI3K/AKT activation	R-HSA-198203	1.495875e-01	0.825
Regulation of Apoptosis	R-HSA-169911	1.812174e-01	0.742
Regulation of gap junction activity	R-HSA-191650	2.701431e-01	0.568
VLDLR internalisation and degradation	R-HSA-8866427	2.054769e-01	0.687
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.440702e-01	0.841
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.126034e-01	0.672
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	2.054769e-01	0.687
GRB2 events in EGFR signaling	R-HSA-179812	2.054769e-01	0.687
Hh mutants are degraded by ERAD	R-HSA-5362768	2.462925e-01	0.609
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.576177e-01	0.589
Myogenesis	R-HSA-525793	2.372098e-01	0.625
Late Phase of HIV Life Cycle	R-HSA-162599	1.415230e-01	0.849
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.372098e-01	0.625
DNA Double Strand Break Response	R-HSA-5693606	2.045048e-01	0.689
Asymmetric localization of PCP proteins	R-HSA-4608870	1.490908e-01	0.827
Degradation of DVL	R-HSA-4641258	2.022691e-01	0.694
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.110403e-01	0.676
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.054769e-01	0.687
HCMV Infection	R-HSA-9609646	1.832275e-01	0.737
HATs acetylate histones	R-HSA-3214847	2.247434e-01	0.648
Beta-catenin independent WNT signaling	R-HSA-3858494	1.860230e-01	0.730
MyD88-independent TLR4 cascade	R-HSA-166166	1.962003e-01	0.707
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.510849e-01	0.600
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.667672e-01	0.778
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.687921e-01	0.773
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.962003e-01	0.707
Signaling by NOTCH1	R-HSA-1980143	1.568131e-01	0.805
mRNA Editing: A to I Conversion	R-HSA-75064	1.893548e-01	0.723
C6 deamination of adenosine	R-HSA-75102	1.893548e-01	0.723
MET interacts with TNS proteins	R-HSA-8875513	2.308077e-01	0.637
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	2.701431e-01	0.568
Ionotropic activity of kainate receptors	R-HSA-451306	1.678925e-01	0.775
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.865502e-01	0.729
Signalling to RAS	R-HSA-167044	1.578301e-01	0.802
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.631438e-01	0.580
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.965273e-01	0.707
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.099046e-01	0.678
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.099046e-01	0.678
Metalloprotease DUBs	R-HSA-5689901	2.372098e-01	0.625
Intraflagellar transport	R-HSA-5620924	1.742200e-01	0.759
Activation of kainate receptors upon glutamate binding	R-HSA-451326	2.650745e-01	0.577
Viral Messenger RNA Synthesis	R-HSA-168325	1.583388e-01	0.800
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.208755e-01	0.656
Deadenylation-dependent mRNA decay	R-HSA-429914	2.773509e-01	0.557
Platelet activation, signaling and aggregation	R-HSA-76002	2.101532e-01	0.677
Signaling by FGFR1 in disease	R-HSA-5655302	2.576177e-01	0.589
Signaling by FGFR2	R-HSA-5654738	1.838236e-01	0.736
Signaling by FGFR4 in disease	R-HSA-5655291	2.438395e-01	0.613
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.812174e-01	0.742
TCF dependent signaling in response to WNT	R-HSA-201681	2.674914e-01	0.573
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.704615e-01	0.768
p75NTR signals via NF-kB	R-HSA-193639	2.631438e-01	0.580
p75NTR recruits signalling complexes	R-HSA-209543	2.054769e-01	0.687
DNA Repair	R-HSA-73894	1.507935e-01	0.822
Signaling by TGFB family members	R-HSA-9006936	2.302575e-01	0.638
Signaling by WNT	R-HSA-195721	2.368853e-01	0.625
Signaling by NODAL	R-HSA-1181150	1.455051e-01	0.837
Negative regulation of MET activity	R-HSA-6807004	1.455051e-01	0.837
Protein ubiquitination	R-HSA-8852135	2.723066e-01	0.565
Signaling by Activin	R-HSA-1502540	2.631438e-01	0.580
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.609539e-01	0.793
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.572896e-01	0.803
Transcriptional regulation by small RNAs	R-HSA-5578749	2.461997e-01	0.609
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	2.275805e-01	0.643
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.676403e-01	0.572
Signaling by FGFR in disease	R-HSA-1226099	2.635271e-01	0.579
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.676403e-01	0.572
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.901434e-01	0.721
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.350813e-01	0.629
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.350813e-01	0.629
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.655764e-01	0.781
Interferon gamma signaling	R-HSA-877300	2.248185e-01	0.648
NADE modulates death signalling	R-HSA-205025	2.701431e-01	0.568
Josephin domain DUBs	R-HSA-5689877	1.495875e-01	0.825
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	2.245963e-01	0.649
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.350813e-01	0.629
G alpha (12/13) signalling events	R-HSA-416482	1.700827e-01	0.769
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.178511e-01	0.662
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.178511e-01	0.662
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.178511e-01	0.662
Base Excision Repair	R-HSA-73884	2.664719e-01	0.574
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.148471e-01	0.668
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.341589e-01	0.630
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	2.510849e-01	0.600
Deubiquitination	R-HSA-5688426	1.407695e-01	0.851
ER to Golgi Anterograde Transport	R-HSA-199977	1.640757e-01	0.785
SWI/SNF chromatin remodelers	R-HSA-9932451	2.234743e-01	0.651
ATP-dependent chromatin remodelers	R-HSA-9932444	2.234743e-01	0.651
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.462925e-01	0.609
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.352017e-01	0.629
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.292203e-01	0.640
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.841695e-01	0.735
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.511288e-01	0.821
Disease	R-HSA-1643685	1.665171e-01	0.779
Interleukin-1 signaling	R-HSA-9020702	2.387598e-01	0.622
The NLRP1 inflammasome	R-HSA-844455	2.308077e-01	0.637
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.495875e-01	0.825
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.245963e-01	0.649
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.631438e-01	0.580
Plasma lipoprotein clearance	R-HSA-8964043	2.239978e-01	0.650
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.462925e-01	0.609
Glucose metabolism	R-HSA-70326	1.561289e-01	0.807
Organelle biogenesis and maintenance	R-HSA-1852241	2.549213e-01	0.594
Opioid Signalling	R-HSA-111885	1.556179e-01	0.808
Processing of DNA double-strand break ends	R-HSA-5693607	1.908619e-01	0.719
Biotin transport and metabolism	R-HSA-196780	2.631438e-01	0.580
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.054769e-01	0.687
Signaling by Hedgehog	R-HSA-5358351	1.966634e-01	0.706
Signaling by TGFBR3	R-HSA-9839373	1.572896e-01	0.803
Signaling by NOTCH3	R-HSA-9012852	2.382379e-01	0.623
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.833702e-01	0.737
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.865502e-01	0.729
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.631438e-01	0.580
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.631438e-01	0.580
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.130558e-01	0.672
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.292203e-01	0.640
Interleukin-7 signaling	R-HSA-1266695	2.234743e-01	0.651
Infectious disease	R-HSA-5663205	1.664994e-01	0.779
Platelet degranulation	R-HSA-114608	2.172793e-01	0.663
Immune System	R-HSA-168256	1.827725e-01	0.738
Formation of paraxial mesoderm	R-HSA-9793380	1.583388e-01	0.800
PIP3 activates AKT signaling	R-HSA-1257604	1.612042e-01	0.793
CD28 dependent Vav1 pathway	R-HSA-389359	2.245963e-01	0.649
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.438395e-01	0.613
Hyaluronan degradation	R-HSA-2160916	2.234743e-01	0.651
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.239978e-01	0.650
MITF-M-dependent gene expression	R-HSA-9856651	1.784233e-01	0.749
Somitogenesis	R-HSA-9824272	1.490908e-01	0.827
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.883121e-01	0.725
G1/S-Specific Transcription	R-HSA-69205	1.916516e-01	0.717
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.126352e-01	0.672
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.438395e-01	0.613
RET signaling	R-HSA-8853659	1.916516e-01	0.717
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.578301e-01	0.802
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.656954e-01	0.781
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.242370e-01	0.649
Signaling by Leptin	R-HSA-2586552	1.495875e-01	0.825
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	2.245963e-01	0.649
Regulation of beta-cell development	R-HSA-186712	2.773509e-01	0.557
Growth hormone receptor signaling	R-HSA-982772	1.965273e-01	0.707
Late endosomal microautophagy	R-HSA-9615710	2.791544e-01	0.554
mRNA Capping	R-HSA-72086	2.791544e-01	0.554
RNA Polymerase II Promoter Escape	R-HSA-73776	2.805567e-01	0.552
Defective pyroptosis	R-HSA-9710421	2.805567e-01	0.552
Hh mutants abrogate ligand secretion	R-HSA-5387390	2.805567e-01	0.552
Response of Mtb to phagocytosis	R-HSA-9637690	2.805567e-01	0.552
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	2.824529e-01	0.549
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.824529e-01	0.549
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.824529e-01	0.549
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	2.824529e-01	0.549
Differentiation of T cells	R-HSA-9945266	2.824529e-01	0.549
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	2.824529e-01	0.549
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.883907e-01	0.540
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.883907e-01	0.540
Eukaryotic Translation Elongation	R-HSA-156842	2.906287e-01	0.537
Proteasome assembly	R-HSA-9907900	2.921442e-01	0.534
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.921442e-01	0.534
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.921442e-01	0.534
EPHB-mediated forward signaling	R-HSA-3928662	2.921442e-01	0.534
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.933012e-01	0.533
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.933012e-01	0.533
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	2.933012e-01	0.533
C-type lectin receptors (CLRs)	R-HSA-5621481	2.991423e-01	0.524
Ribosome-associated quality control	R-HSA-9948299	2.995515e-01	0.524
G beta:gamma signalling through CDC42	R-HSA-8964616	3.017158e-01	0.520
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	3.017158e-01	0.520
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.017158e-01	0.520
GRB2 events in ERBB2 signaling	R-HSA-1963640	3.017158e-01	0.520
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.017158e-01	0.520
Acetylcholine regulates insulin secretion	R-HSA-399997	3.017158e-01	0.520
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.017158e-01	0.520
SARS-CoV-2 Infection	R-HSA-9694516	3.019106e-01	0.520
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	3.037932e-01	0.517
Defective CFTR causes cystic fibrosis	R-HSA-5678895	3.037932e-01	0.517
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.037932e-01	0.517
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.037932e-01	0.517
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.037932e-01	0.517
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.051368e-01	0.516
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	3.074693e-01	0.512
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	3.074693e-01	0.512
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	3.074693e-01	0.512
Nectin/Necl trans heterodimerization	R-HSA-420597	3.074693e-01	0.512
Reelin signalling pathway	R-HSA-8866376	3.074693e-01	0.512
Suppression of autophagy	R-HSA-9636569	3.074693e-01	0.512
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	3.074693e-01	0.512
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	3.074693e-01	0.512
SMAC (DIABLO) binds to IAPs	R-HSA-111463	3.074693e-01	0.512
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.074693e-01	0.512
Assembly of Viral Components at the Budding Site	R-HSA-168316	3.074693e-01	0.512
NCAM signaling for neurite out-growth	R-HSA-375165	3.074802e-01	0.512
tRNA processing in the nucleus	R-HSA-6784531	3.074802e-01	0.512
Sensory processing of sound	R-HSA-9659379	3.080597e-01	0.511
Ub-specific processing proteases	R-HSA-5689880	3.111627e-01	0.507
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	3.154914e-01	0.501
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	3.172185e-01	0.499
rRNA modification in the nucleus and cytosol	R-HSA-6790901	3.176304e-01	0.498
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.208868e-01	0.494
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	3.208868e-01	0.494
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.208868e-01	0.494
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.208868e-01	0.494
Specification of primordial germ cells	R-HSA-9827857	3.208868e-01	0.494
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	3.217079e-01	0.493
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	3.217079e-01	0.493
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	3.217079e-01	0.493
Insulin receptor signalling cascade	R-HSA-74751	3.278207e-01	0.484
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.318819e-01	0.479
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.318819e-01	0.479
Nuclear RNA decay	R-HSA-9930044	3.359262e-01	0.474
Cellular response to hypoxia	R-HSA-1234174	3.380432e-01	0.471
NGF-stimulated transcription	R-HSA-9031628	3.389868e-01	0.470
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.399250e-01	0.469
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.399250e-01	0.469
GAB1 signalosome	R-HSA-180292	3.399250e-01	0.469
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	3.399250e-01	0.469
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.399250e-01	0.469
Apoptotic factor-mediated response	R-HSA-111471	3.399250e-01	0.469
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.399250e-01	0.469
Mismatch Repair	R-HSA-5358508	3.399250e-01	0.469
Nephron development	R-HSA-9831926	3.399250e-01	0.469
Telomere Maintenance	R-HSA-157579	3.402421e-01	0.468
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.428887e-01	0.465
Nef Mediated CD8 Down-regulation	R-HSA-182218	3.428887e-01	0.465
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.428887e-01	0.465
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.428887e-01	0.465
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.428887e-01	0.465
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.428887e-01	0.465
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.428887e-01	0.465
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.428887e-01	0.465
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.428887e-01	0.465
Signaling by MAPK mutants	R-HSA-9652817	3.428887e-01	0.465
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.428887e-01	0.465
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	3.428887e-01	0.465
CDC6 association with the ORC:origin complex	R-HSA-68689	3.428887e-01	0.465
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.428887e-01	0.465
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.428887e-01	0.465
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.428887e-01	0.465
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.428887e-01	0.465
rRNA processing	R-HSA-72312	3.472398e-01	0.459
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.482903e-01	0.458
Signaling by FGFR	R-HSA-190236	3.486289e-01	0.458
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.501284e-01	0.456
Effects of PIP2 hydrolysis	R-HSA-114508	3.501284e-01	0.456
Vpu mediated degradation of CD4	R-HSA-180534	3.501284e-01	0.456
DNA Damage Bypass	R-HSA-73893	3.507609e-01	0.455
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.587939e-01	0.445
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.587939e-01	0.445
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	3.587939e-01	0.445
STING mediated induction of host immune responses	R-HSA-1834941	3.587939e-01	0.445
Regulation of RAS by GAPs	R-HSA-5658442	3.625375e-01	0.441
Signaling by FGFR2 in disease	R-HSA-5655253	3.625375e-01	0.441
Dual Incision in GG-NER	R-HSA-5696400	3.642965e-01	0.439
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	3.642965e-01	0.439
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	3.642965e-01	0.439
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	3.642965e-01	0.439
Hyaluronan metabolism	R-HSA-2142845	3.642965e-01	0.439
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.642965e-01	0.439
Signaling by NOTCH2	R-HSA-1980145	3.642965e-01	0.439
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	3.743061e-01	0.427
Hedgehog ligand biogenesis	R-HSA-5358346	3.743061e-01	0.427
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.764986e-01	0.424
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.764986e-01	0.424
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.764986e-01	0.424
Erythropoietin activates STAT5	R-HSA-9027283	3.764986e-01	0.424
Autointegration results in viral DNA circles	R-HSA-177539	3.764986e-01	0.424
Metabolism of ingested MeSeO2H into MeSeH	R-HSA-5263617	3.764986e-01	0.424
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.764986e-01	0.424
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.764986e-01	0.424
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.764986e-01	0.424
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	3.764986e-01	0.424
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	3.764986e-01	0.424
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.764986e-01	0.424
Neurofascin interactions	R-HSA-447043	3.764986e-01	0.424
Integration of viral DNA into host genomic DNA	R-HSA-175567	3.764986e-01	0.424
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.764986e-01	0.424
Nef and signal transduction	R-HSA-164944	3.764986e-01	0.424
HDL clearance	R-HSA-8964011	3.764986e-01	0.424
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.774611e-01	0.423
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.774611e-01	0.423
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	3.784131e-01	0.422
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	3.784131e-01	0.422
Oncogene Induced Senescence	R-HSA-2559585	3.784131e-01	0.422
Rab regulation of trafficking	R-HSA-9007101	3.824690e-01	0.417
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.860562e-01	0.413
Cyclin E associated events during G1/S transition	R-HSA-69202	3.893746e-01	0.410
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.903138e-01	0.409
PRC2 methylates histones and DNA	R-HSA-212300	3.924621e-01	0.406
Lysosome Vesicle Biogenesis	R-HSA-432720	3.924621e-01	0.406
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.924621e-01	0.406
FLT3 signaling in disease	R-HSA-9682385	3.924621e-01	0.406
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.958979e-01	0.402
Basigin interactions	R-HSA-210991	3.958979e-01	0.402
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.958979e-01	0.402
Meiotic synapsis	R-HSA-1221632	3.977779e-01	0.400
Transcriptional regulation by RUNX2	R-HSA-8878166	3.981634e-01	0.400
NoRC negatively regulates rRNA expression	R-HSA-427413	3.996339e-01	0.398
Hedgehog 'on' state	R-HSA-5632684	3.996339e-01	0.398
Interleukin-1 family signaling	R-HSA-446652	4.020877e-01	0.396
Degradation of AXIN	R-HSA-4641257	4.064282e-01	0.391
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	4.064282e-01	0.391
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.077288e-01	0.390
Activation of HOX genes during differentiation	R-HSA-5619507	4.077288e-01	0.390
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	4.083914e-01	0.389
TRIF-mediated programmed cell death	R-HSA-2562578	4.083914e-01	0.389
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	4.083914e-01	0.389
Disinhibition of SNARE formation	R-HSA-114516	4.083914e-01	0.389
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.083914e-01	0.389
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	4.083914e-01	0.389
NOSTRIN mediated eNOS trafficking	R-HSA-203641	4.083914e-01	0.389
PTK6 Expression	R-HSA-8849473	4.083914e-01	0.389
Nef Mediated CD4 Down-regulation	R-HSA-167590	4.083914e-01	0.389
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.083914e-01	0.389
VLDL clearance	R-HSA-8964046	4.083914e-01	0.389
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	4.083914e-01	0.389
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	4.083914e-01	0.389
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	4.083914e-01	0.389
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	4.083914e-01	0.389
ER-Phagosome pathway	R-HSA-1236974	4.091060e-01	0.388
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.098749e-01	0.387
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	4.140791e-01	0.383
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.140791e-01	0.383
FRS-mediated FGFR3 signaling	R-HSA-5654706	4.140791e-01	0.383
Signaling by NTRK3 (TRKC)	R-HSA-9034015	4.140791e-01	0.383
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.187495e-01	0.378
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.202974e-01	0.376
G alpha (z) signalling events	R-HSA-418597	4.210983e-01	0.376
Toll-like Receptor Cascades	R-HSA-168898	4.230970e-01	0.374
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.275099e-01	0.369
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.319826e-01	0.365
FRS-mediated FGFR4 signaling	R-HSA-5654712	4.319826e-01	0.365
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.319826e-01	0.365
LDL clearance	R-HSA-8964038	4.319826e-01	0.365
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.319826e-01	0.365
Gene Silencing by RNA	R-HSA-211000	4.330484e-01	0.363
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.340562e-01	0.362
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	4.340562e-01	0.362
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	4.340562e-01	0.362
Signaling by ALK	R-HSA-201556	4.340562e-01	0.362
Stabilization of p53	R-HSA-69541	4.340562e-01	0.362
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	4.340562e-01	0.362
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.386546e-01	0.358
Type I hemidesmosome assembly	R-HSA-446107	4.386546e-01	0.358
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.386546e-01	0.358
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	4.386546e-01	0.358
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.386546e-01	0.358
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.386546e-01	0.358
Activation of RAS in B cells	R-HSA-1169092	4.386546e-01	0.358
ROBO receptors bind AKAP5	R-HSA-9010642	4.386546e-01	0.358
SLC-mediated bile acid transport	R-HSA-9958517	4.386546e-01	0.358
phospho-PLA2 pathway	R-HSA-111995	4.386546e-01	0.358
Sodium/Proton exchangers	R-HSA-425986	4.386546e-01	0.358
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.386546e-01	0.358
IRS-mediated signalling	R-HSA-112399	4.441959e-01	0.352
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.476923e-01	0.349
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.476923e-01	0.349
Diseases associated with the TLR signaling cascade	R-HSA-5602358	4.476923e-01	0.349
Diseases of Immune System	R-HSA-5260271	4.476923e-01	0.349
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	4.482009e-01	0.349
Syndecan interactions	R-HSA-3000170	4.495892e-01	0.347
UCH proteinases	R-HSA-5689603	4.505296e-01	0.346
Dual incision in TC-NER	R-HSA-6782135	4.556404e-01	0.341
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.556404e-01	0.341
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.611943e-01	0.336
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.611943e-01	0.336
Mitochondrial RNA degradation	R-HSA-9836573	4.668826e-01	0.331
Extension of Telomeres	R-HSA-180786	4.670053e-01	0.331
snRNP Assembly	R-HSA-191859	4.670053e-01	0.331
Metabolism of non-coding RNA	R-HSA-194441	4.670053e-01	0.331
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.673715e-01	0.330
WNT mediated activation of DVL	R-HSA-201688	4.673715e-01	0.330
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	4.673715e-01	0.330
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.673715e-01	0.330
mRNA Editing	R-HSA-75072	4.673715e-01	0.330
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.673715e-01	0.330
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.673715e-01	0.330
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	4.673715e-01	0.330
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.673715e-01	0.330
Regulation of NPAS4 gene transcription	R-HSA-9768777	4.673715e-01	0.330
Defects in biotin (Btn) metabolism	R-HSA-3323169	4.673715e-01	0.330
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.673715e-01	0.330
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	4.730531e-01	0.325
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	4.745517e-01	0.324
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	4.745517e-01	0.324
Degradation of CRY and PER proteins	R-HSA-9932298	4.745517e-01	0.324
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.745517e-01	0.324
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.745517e-01	0.324
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.782834e-01	0.320
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.782834e-01	0.320
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.782834e-01	0.320
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.782834e-01	0.320
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.782834e-01	0.320
Co-inhibition by PD-1	R-HSA-389948	4.796496e-01	0.319
Regulation of T cell activation by CD28 family	R-HSA-388841	4.810565e-01	0.318
Formation of a pool of free 40S subunits	R-HSA-72689	4.820476e-01	0.317
Eukaryotic Translation Termination	R-HSA-72764	4.820476e-01	0.317
FRS-mediated FGFR1 signaling	R-HSA-5654693	4.838487e-01	0.315
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.838487e-01	0.315
HDMs demethylate histones	R-HSA-3214842	4.838487e-01	0.315
TGFBR3 expression	R-HSA-9839394	4.838487e-01	0.315
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	4.838487e-01	0.315
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.877546e-01	0.312
Cleavage of the damaged pyrimidine	R-HSA-110329	4.877546e-01	0.312
Depyrimidination	R-HSA-73928	4.877546e-01	0.312
IRS-related events triggered by IGF1R	R-HSA-2428928	4.894679e-01	0.310
Regulation of RUNX2 expression and activity	R-HSA-8939902	4.894679e-01	0.310
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.904117e-01	0.309
Signaling by MET	R-HSA-6806834	4.904117e-01	0.309
Transport to the Golgi and subsequent modification	R-HSA-948021	4.921026e-01	0.308
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.946209e-01	0.306
MAPK3 (ERK1) activation	R-HSA-110056	4.946209e-01	0.306
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.946209e-01	0.306
DNA replication initiation	R-HSA-68952	4.946209e-01	0.306
Binding and entry of HIV virion	R-HSA-173107	4.946209e-01	0.306
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.946209e-01	0.306
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	4.946209e-01	0.306
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.946209e-01	0.306
Pexophagy	R-HSA-9664873	4.946209e-01	0.306
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.946209e-01	0.306
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.004757e-01	0.301
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.004757e-01	0.301
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.004757e-01	0.301
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.005526e-01	0.301
Signaling by FGFR4	R-HSA-5654743	5.007941e-01	0.300
Signaling by SCF-KIT	R-HSA-1433557	5.007941e-01	0.300
Adipogenesis	R-HSA-9843745	5.068972e-01	0.295
Cardiac conduction	R-HSA-5576891	5.068972e-01	0.295
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.115314e-01	0.291
Signaling by PTK6	R-HSA-8848021	5.115314e-01	0.291
G1/S DNA Damage Checkpoints	R-HSA-69615	5.115314e-01	0.291
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.115314e-01	0.291
Gastrulation	R-HSA-9758941	5.133101e-01	0.290
Cyclin D associated events in G1	R-HSA-69231	5.136623e-01	0.289
G1 Phase	R-HSA-69236	5.136623e-01	0.289
Circadian clock	R-HSA-9909396	5.144709e-01	0.289
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.167540e-01	0.287
Signaling by FGFR3 in disease	R-HSA-5655332	5.167540e-01	0.287
Signaling by NTRK2 (TRKB)	R-HSA-9006115	5.167540e-01	0.287
Adaptive Immune System	R-HSA-1280218	5.190840e-01	0.285
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.204779e-01	0.284
vRNP Assembly	R-HSA-192905	5.204779e-01	0.284
RHOBTB3 ATPase cycle	R-HSA-9706019	5.204779e-01	0.284
Activated NTRK3 signals through RAS	R-HSA-9034864	5.204779e-01	0.284
Bicarbonate transporters	R-HSA-425381	5.204779e-01	0.284
Suppression of apoptosis	R-HSA-9635465	5.204779e-01	0.284
Dissolution of Fibrin Clot	R-HSA-75205	5.204779e-01	0.284
IGF1R signaling cascade	R-HSA-2428924	5.223988e-01	0.282
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.223988e-01	0.282
Signaling by FGFR3	R-HSA-5654741	5.263516e-01	0.279
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	5.263516e-01	0.279
Ion channel transport	R-HSA-983712	5.306099e-01	0.275
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.326757e-01	0.274
Formation of the Early Elongation Complex	R-HSA-113418	5.326757e-01	0.274
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.326757e-01	0.274
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	5.326757e-01	0.274
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.326757e-01	0.274
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.326757e-01	0.274
Inflammasomes	R-HSA-622312	5.326757e-01	0.274
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.331495e-01	0.273
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	5.345034e-01	0.272
Selenocysteine synthesis	R-HSA-2408557	5.348955e-01	0.272
Meiosis	R-HSA-1500620	5.386882e-01	0.269
Regulation of TNFR1 signaling	R-HSA-5357905	5.388555e-01	0.269
Synthesis of diphthamide-EEF2	R-HSA-5358493	5.450134e-01	0.264
ERKs are inactivated	R-HSA-202670	5.450134e-01	0.264
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.450134e-01	0.264
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.450134e-01	0.264
NF-kB is activated and signals survival	R-HSA-209560	5.450134e-01	0.264
Plasmalogen biosynthesis	R-HSA-75896	5.450134e-01	0.264
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	5.450134e-01	0.264
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.450134e-01	0.264
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.450134e-01	0.264
Activated NTRK2 signals through RAS	R-HSA-9026519	5.450134e-01	0.264
Class I MHC mediated antigen processing & presentation	R-HSA-983169	5.475725e-01	0.262
Signaling by Erythropoietin	R-HSA-9006335	5.482348e-01	0.261
Downstream signaling of activated FGFR3	R-HSA-5654708	5.482348e-01	0.261
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.482348e-01	0.261
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.482348e-01	0.261
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.484458e-01	0.261
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	5.511680e-01	0.259
Synthesis of PC	R-HSA-1483191	5.511680e-01	0.259
Integration of energy metabolism	R-HSA-163685	5.517114e-01	0.258
Viral mRNA Translation	R-HSA-192823	5.520056e-01	0.258
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.542820e-01	0.256
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.574007e-01	0.254
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	5.590195e-01	0.253
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	5.604524e-01	0.251
Metal ion SLC transporters	R-HSA-425410	5.632838e-01	0.249
Co-stimulation by CD28	R-HSA-389356	5.632838e-01	0.249
Downstream signaling of activated FGFR4	R-HSA-5654716	5.634265e-01	0.249
Interleukin-37 signaling	R-HSA-9008059	5.634265e-01	0.249
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.682949e-01	0.245
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.682949e-01	0.245
Repression of WNT target genes	R-HSA-4641265	5.682949e-01	0.245
Signaling by LTK	R-HSA-9842663	5.682949e-01	0.245
MET activates RAS signaling	R-HSA-8851805	5.682949e-01	0.245
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.682949e-01	0.245
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.682949e-01	0.245
SHC-related events triggered by IGF1R	R-HSA-2428933	5.682949e-01	0.245
OAS antiviral response	R-HSA-8983711	5.682949e-01	0.245
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	5.751983e-01	0.240
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.751983e-01	0.240
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.751983e-01	0.240
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	5.782478e-01	0.238
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.787942e-01	0.237
Degradation of beta-catenin by the destruction complex	R-HSA-195253	5.849958e-01	0.233
PI3K Cascade	R-HSA-109704	5.869076e-01	0.231
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.903864e-01	0.229
Processing of SMDT1	R-HSA-8949664	5.903864e-01	0.229
Formation of axial mesoderm	R-HSA-9796292	5.903864e-01	0.229
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.903864e-01	0.229
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.903864e-01	0.229
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.903864e-01	0.229
G0 and Early G1	R-HSA-1538133	5.926969e-01	0.227
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	5.934592e-01	0.227
Activation of NF-kappaB in B cells	R-HSA-1169091	5.984080e-01	0.223
Hemostasis	R-HSA-109582	5.998246e-01	0.222
Antigen processing-Cross presentation	R-HSA-1236975	6.015044e-01	0.221
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	6.017340e-01	0.221
Pre-NOTCH Transcription and Translation	R-HSA-1912408	6.024519e-01	0.220
G-protein beta:gamma signalling	R-HSA-397795	6.067729e-01	0.217
Integrin signaling	R-HSA-354192	6.067729e-01	0.217
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	6.067729e-01	0.217
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.067729e-01	0.217
FGFR1 mutant receptor activation	R-HSA-1839124	6.067729e-01	0.217
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.067729e-01	0.217
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.067729e-01	0.217
RNA Polymerase I Promoter Escape	R-HSA-73772	6.096967e-01	0.215
Neddylation	R-HSA-8951664	6.113348e-01	0.214
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.113487e-01	0.214
CRMPs in Sema3A signaling	R-HSA-399956	6.113487e-01	0.214
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	6.113487e-01	0.214
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.113487e-01	0.214
Respiratory syncytial virus genome transcription	R-HSA-9828642	6.113487e-01	0.214
Regulation of KIT signaling	R-HSA-1433559	6.113487e-01	0.214
Zinc transporters	R-HSA-435354	6.113487e-01	0.214
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.113487e-01	0.214
Ca2+ pathway	R-HSA-4086398	6.144460e-01	0.212
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	6.162415e-01	0.210
TCR signaling	R-HSA-202403	6.173332e-01	0.209
Signaling by Insulin receptor	R-HSA-74752	6.197248e-01	0.208
Resolution of D-Loop Structures	R-HSA-5693537	6.204763e-01	0.207
Miscellaneous transport and binding events	R-HSA-5223345	6.204763e-01	0.207
Regulation of PTEN stability and activity	R-HSA-8948751	6.207713e-01	0.207
G alpha (q) signalling events	R-HSA-416476	6.290730e-01	0.201
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.312395e-01	0.200
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.312395e-01	0.200
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.312395e-01	0.200
G beta:gamma signalling through BTK	R-HSA-8964315	6.312395e-01	0.200
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.312395e-01	0.200
Telomere C-strand synthesis initiation	R-HSA-174430	6.312395e-01	0.200
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.312395e-01	0.200
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.312395e-01	0.200
Lysosphingolipid and LPA receptors	R-HSA-419408	6.312395e-01	0.200
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.312395e-01	0.200
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.312395e-01	0.200
Spry regulation of FGF signaling	R-HSA-1295596	6.312395e-01	0.200
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.312395e-01	0.200
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.316299e-01	0.200
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	6.338083e-01	0.198
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	6.338083e-01	0.198
Mitophagy	R-HSA-5205647	6.338083e-01	0.198
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.338083e-01	0.198
NOD1/2 Signaling Pathway	R-HSA-168638	6.338083e-01	0.198
Reproduction	R-HSA-1474165	6.445376e-01	0.191
Downstream signaling of activated FGFR2	R-HSA-5654696	6.467710e-01	0.189
Downstream signaling of activated FGFR1	R-HSA-5654687	6.467710e-01	0.189
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.467710e-01	0.189
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.467710e-01	0.189
Killing mechanisms	R-HSA-9664420	6.501134e-01	0.187
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.501134e-01	0.187
Class I peroxisomal membrane protein import	R-HSA-9603798	6.501134e-01	0.187
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.501134e-01	0.187
Activation of SMO	R-HSA-5635838	6.501134e-01	0.187
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.501134e-01	0.187
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.501134e-01	0.187
Attachment and Entry	R-HSA-9678110	6.501134e-01	0.187
Virus Assembly and Release	R-HSA-168268	6.501134e-01	0.187
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.516308e-01	0.186
Signaling by FGFR1	R-HSA-5654736	6.526937e-01	0.185
TNF signaling	R-HSA-75893	6.526937e-01	0.185
Detoxification of Reactive Oxygen Species	R-HSA-3299685	6.526937e-01	0.185
Golgi-to-ER retrograde transport	R-HSA-8856688	6.583054e-01	0.182
RUNX2 regulates bone development	R-HSA-8941326	6.593673e-01	0.181
FGFR2 mutant receptor activation	R-HSA-1839126	6.593673e-01	0.181
ABC transporter disorders	R-HSA-5619084	6.605436e-01	0.180
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	6.680224e-01	0.175
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.680224e-01	0.175
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.680224e-01	0.175
Coenzyme A biosynthesis	R-HSA-196783	6.680224e-01	0.175
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.680224e-01	0.175
SHC1 events in ERBB4 signaling	R-HSA-1250347	6.680224e-01	0.175
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.693007e-01	0.174
Ovarian tumor domain proteases	R-HSA-5689896	6.716007e-01	0.173
Regulation of insulin secretion	R-HSA-422356	6.765365e-01	0.170
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	6.779014e-01	0.169
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.834753e-01	0.165
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.834753e-01	0.165
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.850157e-01	0.164
PI3K events in ERBB2 signaling	R-HSA-1963642	6.850157e-01	0.164
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.850157e-01	0.164
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.850157e-01	0.164
Regulation of NPAS4 gene expression	R-HSA-9768759	6.850157e-01	0.164
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.850157e-01	0.164
Choline catabolism	R-HSA-6798163	6.850157e-01	0.164
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.850157e-01	0.164
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.863450e-01	0.163
Metabolism of polyamines	R-HSA-351202	6.921929e-01	0.160
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.949959e-01	0.158
G beta:gamma signalling through PLC beta	R-HSA-418217	7.011402e-01	0.154
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.011402e-01	0.154
Presynaptic function of Kainate receptors	R-HSA-500657	7.011402e-01	0.154
Regulation of TP53 Activity through Methylation	R-HSA-6804760	7.011402e-01	0.154
Polo-like kinase mediated events	R-HSA-156711	7.011402e-01	0.154
Tie2 Signaling	R-HSA-210993	7.011402e-01	0.154
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.043215e-01	0.152
Generation of second messenger molecules	R-HSA-202433	7.061675e-01	0.151
Heme signaling	R-HSA-9707616	7.106327e-01	0.148
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	7.120945e-01	0.147
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.164402e-01	0.145
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.164402e-01	0.145
PI-3K cascade:FGFR3	R-HSA-5654710	7.164402e-01	0.145
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	7.164402e-01	0.145
Germ layer formation at gastrulation	R-HSA-9754189	7.164402e-01	0.145
Pyrimidine biosynthesis	R-HSA-500753	7.164402e-01	0.145
Translesion Synthesis by POLH	R-HSA-110320	7.164402e-01	0.145
The NLRP3 inflammasome	R-HSA-844456	7.164402e-01	0.145
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.164402e-01	0.145
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	7.169957e-01	0.144
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	7.169957e-01	0.144
FLT3 Signaling	R-HSA-9607240	7.169957e-01	0.144
Response of endothelial cells to shear stress	R-HSA-9860931	7.205114e-01	0.142
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.239097e-01	0.140
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.274863e-01	0.138
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.309577e-01	0.136
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.309577e-01	0.136
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.309577e-01	0.136
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.309577e-01	0.136
PI-3K cascade:FGFR4	R-HSA-5654720	7.309577e-01	0.136
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.309577e-01	0.136
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.309577e-01	0.136
Wax and plasmalogen biosynthesis	R-HSA-8848584	7.309577e-01	0.136
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.309577e-01	0.136
Common Pathway of Fibrin Clot Formation	R-HSA-140875	7.309577e-01	0.136
Protein hydroxylation	R-HSA-9629569	7.309577e-01	0.136
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	7.337049e-01	0.134
Selenoamino acid metabolism	R-HSA-2408522	7.380122e-01	0.132
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.425168e-01	0.129
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.425168e-01	0.129
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.425168e-01	0.129
Disorders of transmembrane transporters	R-HSA-5619115	7.429846e-01	0.129
Innate Immune System	R-HSA-168249	7.432022e-01	0.129
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.447329e-01	0.128
G-protein activation	R-HSA-202040	7.447329e-01	0.128
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	7.447329e-01	0.128
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.447329e-01	0.128
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.447329e-01	0.128
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.447329e-01	0.128
SHC-mediated cascade:FGFR3	R-HSA-5654704	7.447329e-01	0.128
Zygotic genome activation (ZGA)	R-HSA-9819196	7.447329e-01	0.128
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	7.447329e-01	0.128
SLC transporter disorders	R-HSA-5619102	7.538338e-01	0.123
RMTs methylate histone arginines	R-HSA-3214858	7.569957e-01	0.121
Netrin-1 signaling	R-HSA-373752	7.569957e-01	0.121
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.578035e-01	0.120
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.578035e-01	0.120
Mitochondrial calcium ion transport	R-HSA-8949215	7.578035e-01	0.120
SHC-mediated cascade:FGFR4	R-HSA-5654719	7.578035e-01	0.120
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.578035e-01	0.120
Attachment and Entry	R-HSA-9694614	7.578035e-01	0.120
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.662000e-01	0.116
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.662000e-01	0.116
PI-3K cascade:FGFR1	R-HSA-5654689	7.702056e-01	0.113
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.702056e-01	0.113
Notch-HLH transcription pathway	R-HSA-350054	7.702056e-01	0.113
Neurotoxicity of clostridium toxins	R-HSA-168799	7.702056e-01	0.113
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.702056e-01	0.113
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.702056e-01	0.113
Signaling by KIT in disease	R-HSA-9669938	7.702056e-01	0.113
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.714949e-01	0.113
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.750998e-01	0.111
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	7.750998e-01	0.111
FCERI mediated MAPK activation	R-HSA-2871796	7.781746e-01	0.109
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	7.819135e-01	0.107
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.819734e-01	0.107
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.819734e-01	0.107
Mitochondrial mRNA modification	R-HSA-9937008	7.819734e-01	0.107
Carnitine shuttle	R-HSA-200425	7.819734e-01	0.107
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.839770e-01	0.106
Cellular responses to mechanical stimuli	R-HSA-9855142	7.896613e-01	0.103
Thromboxane signalling through TP receptor	R-HSA-428930	7.931392e-01	0.101
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.931392e-01	0.101
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.931392e-01	0.101
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.931392e-01	0.101
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.931392e-01	0.101
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.931392e-01	0.101
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.943418e-01	0.100
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.000422e-01	0.097
Translation	R-HSA-72766	8.025135e-01	0.096
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.037338e-01	0.095
G protein gated Potassium channels	R-HSA-1296059	8.037338e-01	0.095
Activation of G protein gated Potassium channels	R-HSA-1296041	8.037338e-01	0.095
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.037338e-01	0.095
PI-3K cascade:FGFR2	R-HSA-5654695	8.037338e-01	0.095
Acyl chain remodelling of PS	R-HSA-1482801	8.037338e-01	0.095
Sema4D in semaphorin signaling	R-HSA-400685	8.037338e-01	0.095
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.037338e-01	0.095
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.119093e-01	0.090
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.137864e-01	0.089
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.137864e-01	0.089
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.137864e-01	0.089
Urea cycle	R-HSA-70635	8.137864e-01	0.089
Sphingolipid catabolism	R-HSA-9845614	8.137864e-01	0.089
Suppression of phagosomal maturation	R-HSA-9637687	8.137864e-01	0.089
Meiotic recombination	R-HSA-912446	8.152782e-01	0.089
The phototransduction cascade	R-HSA-2514856	8.152782e-01	0.089
Mitochondrial biogenesis	R-HSA-1592230	8.163466e-01	0.088
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.225001e-01	0.085
Packaging Of Telomere Ends	R-HSA-171306	8.233247e-01	0.084
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.233247e-01	0.084
RNA Polymerase I Promoter Opening	R-HSA-73728	8.233247e-01	0.084
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.233247e-01	0.084
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.233247e-01	0.084
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	8.233247e-01	0.084
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.233247e-01	0.084
Insulin processing	R-HSA-264876	8.233247e-01	0.084
Nucleotide biosynthesis	R-HSA-8956320	8.294675e-01	0.081
Parasite infection	R-HSA-9664407	8.309746e-01	0.080
Leishmania phagocytosis	R-HSA-9664417	8.309746e-01	0.080
FCGR3A-mediated phagocytosis	R-HSA-9664422	8.309746e-01	0.080
Telomere Extension By Telomerase	R-HSA-171319	8.323750e-01	0.080
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.323750e-01	0.080
ABC-family proteins mediated transport	R-HSA-382556	8.334028e-01	0.079
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.361874e-01	0.078
DNA methylation	R-HSA-5334118	8.409622e-01	0.075
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.409622e-01	0.075
Termination of translesion DNA synthesis	R-HSA-5656169	8.409622e-01	0.075
Glucagon-type ligand receptors	R-HSA-420092	8.409622e-01	0.075
Platelet calcium homeostasis	R-HSA-418360	8.409622e-01	0.075
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.409622e-01	0.075
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.491099e-01	0.071
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.491099e-01	0.071
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.491099e-01	0.071
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.491099e-01	0.071
DAP12 signaling	R-HSA-2424491	8.491099e-01	0.071
Cytoprotection by HMOX1	R-HSA-9707564	8.558476e-01	0.068
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.558476e-01	0.068
Evasion by RSV of host interferon responses	R-HSA-9833109	8.568408e-01	0.067
Downstream signal transduction	R-HSA-186763	8.568408e-01	0.067
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.607331e-01	0.065
Inwardly rectifying K+ channels	R-HSA-1296065	8.641759e-01	0.063
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.641759e-01	0.063
tRNA processing	R-HSA-72306	8.660875e-01	0.062
Peroxisomal protein import	R-HSA-9033241	8.663202e-01	0.062
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	8.703087e-01	0.060
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	8.711357e-01	0.060
Regulation of necroptotic cell death	R-HSA-5675482	8.711357e-01	0.060
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.711357e-01	0.060
Acyl chain remodelling of PC	R-HSA-1482788	8.777392e-01	0.057
Glucagon signaling in metabolic regulation	R-HSA-163359	8.777392e-01	0.057
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.777392e-01	0.057
Extracellular matrix organization	R-HSA-1474244	8.801924e-01	0.055
Signaling by PDGF	R-HSA-186797	8.818688e-01	0.055
Signal amplification	R-HSA-392518	8.840048e-01	0.054
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.840048e-01	0.054
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.840048e-01	0.054
eNOS activation	R-HSA-203615	8.840048e-01	0.054
Calnexin/calreticulin cycle	R-HSA-901042	8.840048e-01	0.054
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.840048e-01	0.054
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.840048e-01	0.054
NPAS4 regulates expression of target genes	R-HSA-9768919	8.840048e-01	0.054
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.840048e-01	0.054
Inositol phosphate metabolism	R-HSA-1483249	8.895489e-01	0.051
Acyl chain remodelling of PE	R-HSA-1482839	8.899495e-01	0.051
PERK regulates gene expression	R-HSA-381042	8.899495e-01	0.051
Defects in vitamin and cofactor metabolism	R-HSA-3296482	8.899495e-01	0.051
PPARA activates gene expression	R-HSA-1989781	8.902598e-01	0.050
Neurotransmitter release cycle	R-HSA-112310	8.915751e-01	0.050
Downstream TCR signaling	R-HSA-202424	8.915751e-01	0.050
RNA Polymerase III Transcription	R-HSA-74158	8.955900e-01	0.048
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.955900e-01	0.048
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.955900e-01	0.048
Triglyceride catabolism	R-HSA-163560	8.955900e-01	0.048
Regulation of TP53 Degradation	R-HSA-6804757	8.955900e-01	0.048
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.962571e-01	0.048
Cellular response to starvation	R-HSA-9711097	8.991494e-01	0.046
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.000042e-01	0.046
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.009417e-01	0.045
TRAF6 mediated IRF7 activation	R-HSA-933541	9.009417e-01	0.045
Cleavage of the damaged purine	R-HSA-110331	9.009417e-01	0.045
SLC-mediated transport of organic cations	R-HSA-549127	9.009417e-01	0.045
Kidney development	R-HSA-9830369	9.041141e-01	0.044
Depurination	R-HSA-73927	9.060194e-01	0.043
MET promotes cell motility	R-HSA-8875878	9.060194e-01	0.043
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.060194e-01	0.043
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.060194e-01	0.043
RAS processing	R-HSA-9648002	9.108371e-01	0.041
Pentose phosphate pathway	R-HSA-71336	9.108371e-01	0.041
Regulation of TP53 Expression and Degradation	R-HSA-6806003	9.108371e-01	0.041
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.129335e-01	0.040
Tryptophan catabolism	R-HSA-71240	9.154081e-01	0.038
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.154081e-01	0.038
COPII-mediated vesicle transport	R-HSA-204005	9.155162e-01	0.038
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.155162e-01	0.038
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.197450e-01	0.036
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.223966e-01	0.035
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.233649e-01	0.035
Scavenging by Class A Receptors	R-HSA-3000480	9.238599e-01	0.034
Cytosolic tRNA aminoacylation	R-HSA-379716	9.277640e-01	0.033
Activation of GABAB receptors	R-HSA-991365	9.277640e-01	0.033
GABA B receptor activation	R-HSA-977444	9.277640e-01	0.033
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.277640e-01	0.033
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.314681e-01	0.031
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.317346e-01	0.031
Surfactant metabolism	R-HSA-5683826	9.349825e-01	0.029
DAP12 interactions	R-HSA-2172127	9.349825e-01	0.029
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.383169e-01	0.028
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.383169e-01	0.028
Fanconi Anemia Pathway	R-HSA-6783310	9.383169e-01	0.028
Integrin cell surface interactions	R-HSA-216083	9.400026e-01	0.027
Diseases of DNA repair	R-HSA-9675135	9.414805e-01	0.026
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.414805e-01	0.026
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.414805e-01	0.026
Regulation of pyruvate metabolism	R-HSA-9861718	9.414805e-01	0.026
RSV-host interactions	R-HSA-9833110	9.424246e-01	0.026
Bacterial Infection Pathways	R-HSA-9824439	9.452285e-01	0.024
Amyloid fiber formation	R-HSA-977225	9.473138e-01	0.024
GPER1 signaling	R-HSA-9634597	9.473297e-01	0.023
Chemokine receptors bind chemokines	R-HSA-380108	9.500316e-01	0.022
HCMV Late Events	R-HSA-9610379	9.517646e-01	0.021
Parasitic Infection Pathways	R-HSA-9824443	9.536078e-01	0.021
Leishmania infection	R-HSA-9658195	9.536078e-01	0.021
Complex IV assembly	R-HSA-9864848	9.550270e-01	0.020
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.573344e-01	0.019
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.652633e-01	0.015
Role of phospholipids in phagocytosis	R-HSA-2029485	9.652633e-01	0.015
Amino acid transport across the plasma membrane	R-HSA-352230	9.704933e-01	0.013
Triglyceride metabolism	R-HSA-8979227	9.704933e-01	0.013
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.704933e-01	0.013
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.715547e-01	0.013
RAB geranylgeranylation	R-HSA-8873719	9.720079e-01	0.012
GABA receptor activation	R-HSA-977443	9.720079e-01	0.012
tRNA Aminoacylation	R-HSA-379724	9.720079e-01	0.012
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.720079e-01	0.012
Post-translational protein modification	R-HSA-597592	9.723181e-01	0.012
Aquaporin-mediated transport	R-HSA-445717	9.734449e-01	0.012
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.748082e-01	0.011
SLC-mediated transport of amino acids	R-HSA-9958863	9.806448e-01	0.008
Regulated Necrosis	R-HSA-5218859	9.816388e-01	0.008
Degradation of the extracellular matrix	R-HSA-1474228	9.838417e-01	0.007
Metabolism of cofactors	R-HSA-8978934	9.843252e-01	0.007
Platelet homeostasis	R-HSA-418346	9.855275e-01	0.006
Asparagine N-linked glycosylation	R-HSA-446203	9.855499e-01	0.006
Stimuli-sensing channels	R-HSA-2672351	9.867880e-01	0.006
Iron uptake and transport	R-HSA-917937	9.873065e-01	0.006
G alpha (i) signalling events	R-HSA-418594	9.888145e-01	0.005
SLC-mediated transport of organic anions	R-HSA-9955298	9.891644e-01	0.005
Cholesterol biosynthesis	R-HSA-191273	9.891644e-01	0.005
FCERI mediated NF-kB activation	R-HSA-2871837	9.909622e-01	0.004
GPCR downstream signalling	R-HSA-388396	9.912307e-01	0.004
Cell surface interactions at the vascular wall	R-HSA-202733	9.925471e-01	0.003
Pyruvate metabolism	R-HSA-70268	9.936076e-01	0.003
Protein localization	R-HSA-9609507	9.938199e-01	0.003
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.940405e-01	0.003
Formation of the cornified envelope	R-HSA-6809371	9.942351e-01	0.003
Class B/2 (Secretin family receptors)	R-HSA-373080	9.945439e-01	0.002
Mitochondrial protein degradation	R-HSA-9837999	9.958101e-01	0.002
Collagen formation	R-HSA-1474290	9.958101e-01	0.002
Potassium Channels	R-HSA-1296071	9.964241e-01	0.002
Post-translational protein phosphorylation	R-HSA-8957275	9.967826e-01	0.001
Synthesis of bile acids and bile salts	R-HSA-192105	9.969482e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.971342e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.972703e-01	0.001
PI Metabolism	R-HSA-1483255	9.973956e-01	0.001
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.975296e-01	0.001
Visual phototransduction	R-HSA-2187338	9.983810e-01	0.001
Bile acid and bile salt metabolism	R-HSA-194068	9.983816e-01	0.001
Antimicrobial peptides	R-HSA-6803157	9.984649e-01	0.001
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.985963e-01	0.001
Signaling by GPCR	R-HSA-372790	9.986814e-01	0.001
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.987576e-01	0.001
Transport of small molecules	R-HSA-382551	9.988253e-01	0.001
Glycosaminoglycan metabolism	R-HSA-1630316	9.989628e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.989945e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.993027e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.994077e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.994665e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.995562e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.995562e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.997178e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.997192e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.997582e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.997636e-01	0.000
Metabolism of proteins	R-HSA-392499	9.997657e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.998134e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.998863e-01	0.000
Keratinization	R-HSA-6805567	9.999153e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999636e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999696e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999976e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999981e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999994e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999999e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999999e-01	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000