LATS2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00170 S43 Sugiyama AIP XAP2 GELPDFQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELI
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15143 S330 Sugiyama ARPC1B ARC41 ssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTTGM
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43623 T208 PSP SNAI2 SLUG SLUGH KICGKAFSRPWLLQGHIRTHtGEKPFSCPHCNRAFADRSNL
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60828 S247 PSP PQBP1 NPW38 JM26 AKTGADttAAGPLFQQRPyPsPGAVLRANAEASRTKQQD__
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60927 T75 Sugiyama PPP1R11 HCGV TCTE5 RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O75376 S2164 Sugiyama NCOR1 KIAA1047 sEPyEPIsPPQVPVVHEKQDsLLLLSQRGAEPAEQRNDARs
O75937 S81 Sugiyama DNAJC8 SPF31 HSPC315 HSPC331 VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95633 T228 Sugiyama FSTL3 FLRG UNQ674/PRO1308 QELCGNNNVTYISSCHMRQAtCFLGRSIGVRHAGSCAGTPE
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95721 S204 Sugiyama SNAP29 MSTDAYPKNPHLRAYHQKIDsNLDELsMGLGRLKDIALGMQ
O95863 T203 SIGNOR|EPSD|PSP SNAI1 SNAH GTCGKAFSRPWLLQGHVRTHtGEKPFSCPHCSRAFADRSNL
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00519 T178 SIGNOR ABL1 ABL JTK7 PGQRSISLRYEGRVyHYRINtASDGKLyVSSESRFNTLAEL
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S173 Sugiyama ANXA1 ANX1 LPC1 NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04632 Y87 Sugiyama CAPNS1 CAPN4 CAPNS sAISEAAAQYNPEPPPPRtHysNIEANEsEEVRQFRRLFAQ
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S410 Sugiyama KRT8 CYK8 TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06493 T14 Sugiyama CDK1 CDC2 CDC28A CDKN1 P34CDC2 _______MEDyTKIEKIGEGtyGVVyKGRHKTTGQVVAMKK
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 S449 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB ANEVEAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKF
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07737 T65 Sugiyama PFN1 PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737 Y60 Sugiyama PFN1 FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09661 S212 Sugiyama SNRPA1 KKGGPsPGDVEAIKNAIANAstLAEVERLKGLLQsGQIPGR
P09923 S111 Sugiyama ALPI DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S58 Sugiyama H1-4 H1F4 HIST1H1E PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11908 T285 SIGNOR|PSP PRPS2 AFEAVVVTNTIPQEDKMKHCtKIQVIDISMILAEAIRRTHN
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12268 S416 Sugiyama IMPDH2 IMPD2 APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P13073 S72 Sugiyama COX4I1 COX4 VKHLSASQKALKEKEKASWssLsMDEKVELYRIKFKEsFAE
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667 S126 Sugiyama PDIA4 ERP70 ERP72 NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14618 S97 Sugiyama PKM OIP3 PK2 PK3 PKM2 sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15531 S120 Sugiyama NME1 NDPKA NM23 KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P16083 S80 Sugiyama NQO2 NMOR2 LSNPEVFNyGVEtHEAyKQRsLAsDITDEQKKVREADLVIF
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S59 Sugiyama H1-3 H1F3 HIST1H1D PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S58 Sugiyama H1-2 H1F2 HIST1H1C PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987 S544 Sugiyama TCP1 CCT1 CCTA ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18615 S113 Sugiyama NELFE RD RDBP EGKLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLy
P18858 T183 Sugiyama LIG1 sLTEAEVAtEKEGEDGDQPttPPKPLKTSKAEtPtEsVsEP
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P20042 S67 Sugiyama EIF2S2 EIF2B EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P21333 S1459 Sugiyama FLNA FLN FLN1 KVPVHDVTDASKVKCsGPGLsPGMVRANLPQsFQVDTSKAG
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23381 S358 Sugiyama WARS1 IFI53 WARS WRS TFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFs
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P24941 T14 Sugiyama CDK2 CDKN2 _______MENFQKVEKIGEGtyGVVyKARNKLTGEVVALKK
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P29692 S70 Sugiyama EEF1D EF1D IARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVE
P29692 S74 Sugiyama EEF1D EF1D RENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQsL
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P30086 S54 Sugiyama PEBP1 PBP PEBP VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30101 Y356 Sugiyama PDIA3 ERP57 ERP60 GRP58 FVMQEEFsRDGKALERFLQDyFDGNLKRyLKsEPIPESNDG
P31153 Y235 Sugiyama MAT2A AMS2 MATA2 LDEMRDALKEKVIKAVVPAKyLDEDtIyHLQPsGRFVIGGP
P31327 S898 Sugiyama CPS1 LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS
P31327 T900 Sugiyama CPS1 KMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQISKC
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P33176 S717 Sugiyama KIF5B KNS KNS1 VKQAVEQQIQSHRETHQKQIssLRDEVEAKAKLITDLQDQN
P33176 S950 Sugiyama KIF5B KNS KNS1 PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 S76 Sugiyama HSPA4 APG2 HSPH2 VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P34932 T365 Sugiyama HSPA4 APG2 HSPH2 TRIPAVKEKISKFFGKELsttLNADEAVTRGCALQCAILsP
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 S55 Sugiyama RPL4 RPL1 DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR
P36578 T62 Sugiyama RPL4 RPL1 TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38936 S146 EPSD|PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 QAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP__
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P40855 S147 Sugiyama PEX19 HK33 PXF OK/SW-cl.22 SCLKETLSGLAKNATDLQNssMsEEELTKAMEGLGMDEGDG
P40925 S153 Sugiyama MDH1 MDHA ANtNCLtAsKSAPSIPKENFsCLtRLDHNRAKAQIALKLGV
P41252 S1047 Sugiyama IARS1 IARS ESHTEFIFTTIKAPLKPYPVsPsDKVLIQEKTQLKGSELEI
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46108 S41 Sugiyama CRK QEAVALLQGQRHGVFLVRDsstsPGDyVLSVSENSRVSHYI
P46108 Y47 Sugiyama CRK LQGQRHGVFLVRDsstsPGDyVLSVSENSRVSHYIINSSGP
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937 S109 GPS6|PSP|Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937 S127 GPS6|SIGNOR|EPSD|PSP YAP1 YAP65 QAstDAGtAGALtPQHVRAHssPAsLQLGAVsPGtLtPtGV
P46937 S164 GPS6|PSP YAP1 YAP65 PtGVVsGPAAtPTAQHLRQssFEIPDDVPLPAGWEMAKTSS
P46937 S397 GPS6|SIGNOR|Sugiyama YAP1 YAP65 MttNssDPFLNsGtyHsRDEstDsGLsMssysVPRtPDDFL
P46937 S61 GPS6|EPSD|PSP YAP1 YAP65 tQAAPQAPPAGHQIVHVRGDsEtDLEALFNAVMNPKtANVP
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321 S659 Sugiyama NASP IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49327 S207 Sugiyama FASN FAS GINVLLKPNTSVQFLRLGMLsPEGtCKAFDtAGNGYCRSEG
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50454 S139 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P50454 S141 Sugiyama SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI
P50990 S23 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 T598 Sugiyama FXR2 FMR1L2 DESRPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRA
P51532 S1382 Sugiyama SMARCA4 BAF190A BRG1 SNF2B SNF2L4 EEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEIEE
P51858 S165 Sugiyama HDGF HMG1L2 AKEKNEKGALKRRAGDLLEDsPKRPKEAENPEGEEKEAAtL
P52948 S679 Sugiyama NUP98 ADAR2 ytNPIAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRN
P52948 S681 Sugiyama NUP98 ADAR2 NPIAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGL
P52948 S683 Sugiyama NUP98 ADAR2 IAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEG
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60891 S285 SIGNOR|PSP PRPS1 CFEAVVVTNTIPQEDKMKHCsKIQVIDISMILAEAIRRTHN
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978 S420 Sugiyama HNRNPK HNRPK GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S59 SIGNOR|EPSD|PSP YWHAG NEERNLLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKI
P62241 S160 Sugiyama RPS8 OK/SW-cl.83 KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
Q00526 T14 Sugiyama CDK3 CDKN3 _______MDMFQKVEKIGEGtyGVVyKAKNRETGQLVALKK
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01650 S31 Sugiyama SLC7A5 CD98LC LAT1 MPE16 LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q02241 S716 EPSD|PSP KIF23 KNSL5 MKLP1 AQISNGQQLMSQPQLHRRsNsCssISVASCISEWEQKIPTy
Q02241 S814 EPSD|PSP KIF23 KNSL5 MKLP1 LLFQPDQNAPPIRLRHRRsRsAGDRWVDHKPASNMQTETVM
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q13155 S48 Sugiyama AIMP2 JTV1 PRO0992 PNVHGRSyGPAPGAGHVQEEsNLsLQALESRQDDILKRLYE
Q13873 S375 Sugiyama BMPR2 PPH1 SMRLTGNRLVRPGEEDNAAIsEVGtIRYMAPEVLEGAVNLR
Q14152 S1256 Sugiyama EIF3A EIF3S10 KIAA0139 EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152 T216 Sugiyama EIF3A EIF3S10 KIAA0139 KLCDNLRMHLsQIQRHHNQstAINLNNPESQsMHLETRLVQ
Q14498 S336 Sugiyama RBM39 HCC1 RNPC2 LAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGR
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14669 S987 Sugiyama TRIP12 KIAA0045 ULF AAtHAAADLGsPSLQHSRDDsLDLsPQGRLsDVLKRKRLPK
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14697 S913 Sugiyama GANAB G2AN KIAA0088 VIIGAGKPAAVVLQTKGSPEsRLsFQHDPEtsVLVLRKPGI
Q14697 S924 Sugiyama GANAB G2AN KIAA0088 VLQTKGSPEsRLsFQHDPEtsVLVLRKPGINVASDWSIHLR
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14872 S152 SIGNOR|PSP MTF1 TKRKEVKRYQCTFEGCPRTYsTAGNLRTHQKTHRGEYTFVC
Q14978 S686 Sugiyama NOLC1 KIAA0035 NS5ATP13 KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15293 Y115 Sugiyama RCN1 RCN GDGFVttEELKtWIKRVQKRyIFDNVAKVWKDYDRDKDDKI
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q3V6T2 S1172 Sugiyama CCDC88A APE GRDN KIAA1212 LyDSLIKDHEKLELLHERQAsEyESLISKHGTLKSAHKNLE
Q4VCS5 S175 SIGNOR|EPSD|PSP AMOT KIAA1071 GKMHQDEGLRDLKQGHVRSLsERLMQMSLATSGVKAHPPVT
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5T5C0 S692 Sugiyama STXBP5 LLGL3 YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q674X7 S318 Sugiyama KAZN C1orf196 KAZ KIAA1026 HRIHFB2003 PPHPADRQAVRVsPCHSRQPsVISDASAAEGDRsstPSDIN
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6PCE3 S175 Sugiyama PGM2L1 BM32A PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PKG0 S627 Sugiyama LARP1 KIAA0731 LARP FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8N122 S606 PSP RPTOR KIAA1303 RAPTOR QNFDSARWCGVRDSAHEKLYsLLSDPIPEVRCAAVFALGTF
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8N684 S166 Sugiyama CPSF7 PGKVLNGEKVDVRPAtRQNLsQFEAQARKRECVRVPRGGIP
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8ND56 S368 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A EGNADEEDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEE
Q8ND56 S374 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A EDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEERRLNAE
Q8NHZ8 T7 SIGNOR|EPSD|PSP CDC26 ANAPC12 C9orf17 ______________MLRRKPtRLELKLDDIEEFENIRKDLE
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8WX93 S479 Sugiyama PALLD KIAA0992 CGI-151 VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96GQ7 S79 Sugiyama DDX27 cPERP-F RHLP HSPC259 PP3241 EEEEGPIVLGRRQKALGKNRsADFNPDFVFTEKEGTyDGsW
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q99570 S853 Sugiyama PIK3R4 VPS15 LVKTKQEPDDKRARKHVKQDsNVNEEWKsMFGsLDPPNMPQ
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZF1 T355 Sugiyama OSBPL8 KIAA1451 ORP8 OSBP10 NDQEHDEsDNEVMGKSEEsDtDtsERQDDsYIEPEPVEPLK
Q9C0C2 S920 Sugiyama TNKS1BP1 KIAA1741 TAB182 QDANEQGQDLGKRDHHGRyssQDADEQDWEFQKRDVsLGTy
Q9C0D5 S1830 Sugiyama TANC1 KIAA1728 IPVHSQENRITKTVSHLyQEsISKQQPHISNEAHRSHLTAA
Q9GZV5 S311 GPS6|EPSD WWTR1 TAZ ItNNssDPFLNGGPyHsREQsTDsGLGLGCySVPTtPEDFL
Q9GZV5 S89 GPS6|SIGNOR|EPSD|PSP WWTR1 TAZ SsGGHPGPRLAGGAQHVRsHssPAsLQLGtGAGAAGsPAQQ
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9H7E9 T40 Sugiyama C8orf33 PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9NPD3 S240 Sugiyama EXOSC4 RRP41 SKI6 AARDVHTLLDRVVRQHVREAsILLGD_______________
Q9NPQ8 T441 Sugiyama RIC8A AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQS7 S894 EPSD|PSP INCENP PLDLEDIFKKSKPRYHKRtssAVWNsPPLQGARVPssLAYs
Q9NR30 S706 Sugiyama DDX21 PTASVTEIQEKWHDSRRWQLsVATEQPELEGPREGYGGFRG
Q9NRM7 S576 Sugiyama LATS2 KPM KSRKSAKGDKGGKDKKQIQtsPVPVRKNSRDEEKRESRIKS
Q9NRM7 S653 Sugiyama LATS2 KPM KAGLCEAEQEQMRKILYQKEsNYNRLKRAKMDKSMFVKIKT
Q9NRM7 S829 Sugiyama LATS2 KPM DFGLCTGFRWTHNSKYYQKGsHVRQDsMEPsDLWDDVsNCR
Q9NRM7 S835 PSP|Sugiyama LATS2 KPM GFRWTHNSKYYQKGsHVRQDsMEPsDLWDDVsNCRCGDRLK
Q9NRM7 S839 Sugiyama LATS2 KPM THNSKYYQKGsHVRQDsMEPsDLWDDVsNCRCGDRLKTLEQ
Q9NRM7 S846 Sugiyama LATS2 KPM QKGsHVRQDsMEPsDLWDDVsNCRCGDRLKTLEQRARKQHQ
Q9NRM7 T1024 Sugiyama LATS2 KPM PVDEESPWNDASEGSTKAWDtLtsPNNKHPEHAFYEFtFRR
Q9NRM7 T1026 Sugiyama LATS2 KPM DEESPWNDASEGSTKAWDtLtsPNNKHPEHAFYEFtFRRFF
Q9NRM7 Y1051 Sugiyama LATS2 KPM KHPEHAFYEFtFRRFFDDNGyPFRCPKPSGAEASQAESSDL
Q9NRM7 Y694 Sugiyama LATS2 KPM LGIGAFGEVCLACKVDTHALyAMKTLRKKDVLNRNQVAHVK
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NTZ6 S525 Sugiyama RBM12 KIAA0765 HRIHFB2091 ITKKGMLEKIDMIRKRLQNFsyDQREMILNPEGDVNSAKVC
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKG9 S8 Sugiyama CROT COT _____________MENQLAKstEERTFQYQDSLPSLPVPSL
Q9UKG9 T9 Sugiyama CROT COT ____________MENQLAKstEERTFQYQDSLPSLPVPSLE
Q9UKV3 S388 Sugiyama ACIN1 ACINUS KIAA0670 EEEEREIKssQGLKEKsKsPsPPRLtEDRKKAsLVALPEQt
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UPR0 T584 Sugiyama PLCL2 KIAA1092 PLCE2 KILIKAKKLsSNCSGVEGDVtDEDEGAEMSQRMGKENMEQP
Q9Y266 T145 Sugiyama NUDC AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2J4 S159 SIGNOR|EPSD|PSP AMOTL2 KIAA0989 GSRRQDEALRELRHGHVRsLsERLLQLsLERNGARAPsHMs
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y5L4 S57 Sugiyama TIMM13 TIM13B TIMM13A TIMM13B ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW
Q9Y5U2 S86 Sugiyama TSSC4 PSPPSGLLPATVQPFHLRGMssTFSQRsRDIFDCLEGAARR
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.352058e-07 6.361 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.851150e-06 5.733 0 0
mRNA Splicing R-HSA-72172 7.775568e-06 5.109 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.206924e-06 5.036 0 0
Gene expression (Transcription) R-HSA-74160 9.821653e-06 5.008 0 0
RNA Polymerase II Transcription R-HSA-73857 3.675446e-05 4.435 0 0
Signaling by Hippo R-HSA-2028269 5.688386e-05 4.245 1 1
NRAGE signals death through JNK R-HSA-193648 6.449493e-05 4.190 0 0
mRNA 3'-end processing R-HSA-72187 8.194224e-05 4.086 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.107864e-04 3.956 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.515056e-04 3.820 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.723585e-04 3.764 0 0
G alpha (12/13) signalling events R-HSA-416482 1.863203e-04 3.730 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.248241e-04 3.488 0 0
Activation of RAC1 R-HSA-428540 3.731871e-04 3.428 0 0
Regulation of TP53 Activity R-HSA-5633007 4.213937e-04 3.375 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.568052e-04 3.340 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.061432e-04 3.296 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.134384e-04 3.290 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.891387e-04 3.162 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.891387e-04 3.162 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.891387e-04 3.162 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.891387e-04 3.162 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.332460e-04 3.135 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.084047e-04 3.092 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.000373e-03 3.000 0 0
HDMs demethylate histones R-HSA-3214842 1.000373e-03 3.000 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.219529e-03 2.914 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.223693e-03 2.912 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.283442e-03 2.892 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.869596e-03 2.728 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.842102e-03 2.735 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.980472e-03 2.703 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.115359e-03 2.675 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.290214e-03 2.640 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.427271e-03 2.615 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.709129e-03 2.567 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.952941e-03 2.530 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.952941e-03 2.530 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.071083e-03 2.513 0 0
Cell Cycle R-HSA-1640170 3.059700e-03 2.514 0 0
Cell Cycle Checkpoints R-HSA-69620 3.176465e-03 2.498 0 0
Generic Transcription Pathway R-HSA-212436 3.449210e-03 2.462 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.416513e-03 2.466 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.567271e-03 2.448 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.987385e-03 2.399 0 0
Apoptotic execution phase R-HSA-75153 4.073026e-03 2.390 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.280640e-03 2.368 0 0
Chromatin modifying enzymes R-HSA-3247509 4.329089e-03 2.364 0 0
Chromatin organization R-HSA-4839726 4.517774e-03 2.345 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.113999e-03 2.291 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.631533e-03 2.249 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.664819e-03 2.247 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.048745e-03 2.218 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.689277e-03 2.175 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.126820e-03 2.147 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.806584e-03 2.108 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 8.678291e-03 2.062 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.506761e-03 2.070 0 0
Interleukin-12 signaling R-HSA-9020591 8.569329e-03 2.067 0 0
Death Receptor Signaling R-HSA-73887 8.871634e-03 2.052 0 0
Diseases of DNA repair R-HSA-9675135 9.804604e-03 2.009 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.144561e-02 1.941 0 0
Metabolism of RNA R-HSA-8953854 1.282304e-02 1.892 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.286624e-02 1.891 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.356607e-02 1.868 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.371414e-02 1.863 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.392284e-02 1.856 0 0
Interleukin-12 family signaling R-HSA-447115 1.510328e-02 1.821 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.701387e-02 1.769 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.710123e-02 1.767 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.849016e-02 1.733 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.970455e-02 1.705 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.970455e-02 1.705 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.121010e-02 1.673 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.252415e-02 1.647 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.380942e-02 1.623 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.346345e-02 1.630 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.346345e-02 1.630 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.275828e-02 1.643 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.316138e-02 1.635 0 0
Formation of the anterior neural plate R-HSA-9823739 2.225946e-02 1.652 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.516870e-02 1.599 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.639035e-02 1.579 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.784246e-02 1.555 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.137647e-02 1.503 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.137647e-02 1.503 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.137647e-02 1.503 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.137647e-02 1.503 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.377029e-02 1.471 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.619125e-02 1.441 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.619125e-02 1.441 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.564231e-02 1.448 0 0
Netrin-1 signaling R-HSA-373752 3.713461e-02 1.430 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.739779e-02 1.427 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.739779e-02 1.427 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.739779e-02 1.427 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.897155e-02 1.409 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.021819e-02 1.396 0 0
Specification of primordial germ cells R-HSA-9827857 4.074241e-02 1.390 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.593745e-02 1.338 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.593745e-02 1.338 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.593745e-02 1.338 0 0
Lipophagy R-HSA-9613354 4.861227e-02 1.313 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.861227e-02 1.313 0 0
Ephrin signaling R-HSA-3928664 4.856138e-02 1.314 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.856138e-02 1.314 0 0
PKA activation in glucagon signalling R-HSA-164378 4.856138e-02 1.314 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.974223e-02 1.303 0 0
Neurexins and neuroligins R-HSA-6794361 4.332902e-02 1.363 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.015664e-02 1.300 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.954272e-02 1.305 0 0
Signaling by ROBO receptors R-HSA-376176 4.965476e-02 1.304 0 0
Axon guidance R-HSA-422475 4.444801e-02 1.352 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.856138e-02 1.314 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.899150e-02 1.310 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.861227e-02 1.313 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.856138e-02 1.314 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.204036e-02 1.284 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.661866e-02 1.247 0 0
Neurodegenerative Diseases R-HSA-8863678 5.661866e-02 1.247 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.661866e-02 1.247 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.147823e-02 1.211 0 0
Trafficking of AMPA receptors R-HSA-399719 6.201939e-02 1.207 0 0
RUNX2 regulates bone development R-HSA-8941326 5.860652e-02 1.232 0 0
RET signaling R-HSA-8853659 5.860652e-02 1.232 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.689991e-02 1.245 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.970637e-02 1.224 0 0
Co-stimulation by CD28 R-HSA-389356 5.689991e-02 1.245 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.325538e-02 1.199 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.325538e-02 1.199 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.325538e-02 1.199 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.325538e-02 1.199 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.067061e-01 0.972 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.067061e-01 0.972 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.580568e-02 1.120 0 0
Regulation of cortical dendrite branching R-HSA-8985801 7.580568e-02 1.120 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.020316e-01 0.695 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.020316e-01 0.695 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.020316e-01 0.695 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.020316e-01 0.695 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.020316e-01 0.695 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.020316e-01 0.695 0 0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS) R-HSA-5619068 2.020316e-01 0.695 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.020316e-01 0.695 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.020316e-01 0.695 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.020316e-01 0.695 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 8.312771e-02 1.080 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.478357e-01 0.830 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.478357e-01 0.830 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.478357e-01 0.830 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.478357e-01 0.830 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.871897e-01 0.542 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 2.871897e-01 0.542 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 2.871897e-01 0.542 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.871897e-01 0.542 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 2.871897e-01 0.542 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.871897e-01 0.542 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.871897e-01 0.542 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.053050e-01 0.978 0 0
Activation of AKT2 R-HSA-165158 1.875487e-01 0.727 0 0
IRS activation R-HSA-74713 1.875487e-01 0.727 0 0
Type I hemidesmosome assembly R-HSA-446107 1.295095e-01 0.888 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.094782e-01 0.961 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.554494e-01 0.808 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.284929e-01 0.641 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.284929e-01 0.641 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.284929e-01 0.641 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.284929e-01 0.641 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.284929e-01 0.641 0 0
PDE3B signalling R-HSA-165160 2.284929e-01 0.641 0 0
PKB-mediated events R-HSA-109703 2.284929e-01 0.641 0 0
Signaling by MAPK mutants R-HSA-9652817 2.284929e-01 0.641 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.632642e-01 0.440 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.632642e-01 0.440 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.632642e-01 0.440 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.632642e-01 0.440 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.632642e-01 0.440 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.632642e-01 0.440 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.632642e-01 0.440 0 0
Potassium transport channels R-HSA-1296067 3.632642e-01 0.440 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.632642e-01 0.440 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.632642e-01 0.440 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.632642e-01 0.440 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.632642e-01 0.440 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.632642e-01 0.440 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.632642e-01 0.440 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.632642e-01 0.440 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.632642e-01 0.440 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 3.632642e-01 0.440 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.632642e-01 0.440 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.283296e-01 0.892 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.283296e-01 0.892 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.722479e-02 1.112 0 0
Formation of apoptosome R-HSA-111458 1.828304e-01 0.738 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.828304e-01 0.738 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.828304e-01 0.738 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.828304e-01 0.738 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.828304e-01 0.738 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 1.063451e-01 0.973 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.494225e-02 1.187 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.484232e-01 0.828 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.484232e-01 0.828 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.699538e-01 0.569 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.006564e-01 0.997 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.113634e-01 0.675 0 0
DCC mediated attractive signaling R-HSA-418885 1.696315e-01 0.770 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.696315e-01 0.770 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.381509e-01 0.860 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.411770e-02 1.026 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.838151e-02 1.106 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.744133e-02 1.058 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.407715e-01 0.618 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.407715e-01 0.618 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.407715e-01 0.618 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.113554e-01 0.507 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.113554e-01 0.507 0 0
Netrin mediated repulsion signals R-HSA-418886 3.113554e-01 0.507 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.113554e-01 0.507 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.113554e-01 0.507 0 0
SOS-mediated signalling R-HSA-112412 3.113554e-01 0.507 0 0
Disinhibition of SNARE formation R-HSA-114516 3.113554e-01 0.507 0 0
Recycling of eIF2:GDP R-HSA-72731 3.113554e-01 0.507 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.113554e-01 0.507 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.113554e-01 0.507 0 0
PLC-gamma1 signalling R-HSA-167021 4.312238e-01 0.365 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.312238e-01 0.365 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.312238e-01 0.365 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.312238e-01 0.365 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.312238e-01 0.365 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.312238e-01 0.365 0 0
Invadopodia formation R-HSA-8941237 4.312238e-01 0.365 0 0
MET activates PTPN11 R-HSA-8865999 4.312238e-01 0.365 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.094672e-02 1.092 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.939623e-02 1.049 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.148537e-01 0.668 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.148537e-01 0.668 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.707935e-01 0.567 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.707935e-01 0.567 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.707935e-01 0.567 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.707935e-01 0.567 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.707935e-01 0.567 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.707935e-01 0.567 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.707935e-01 0.567 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.707935e-01 0.567 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.425170e-01 0.846 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.294332e-01 0.888 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.731074e-01 0.762 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.731074e-01 0.762 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.522385e-01 0.453 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.522385e-01 0.453 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.522385e-01 0.453 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.522385e-01 0.453 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.177327e-01 0.929 0 0
Integrin signaling R-HSA-354192 1.561900e-01 0.806 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 7.542636e-02 1.122 0 0
HIV elongation arrest and recovery R-HSA-167287 1.896714e-01 0.722 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.896714e-01 0.722 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.011874e-01 0.521 0 0
Formation of axial mesoderm R-HSA-9796292 3.011874e-01 0.521 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.628981e-01 0.580 0 0
GAB1 signalosome R-HSA-180292 2.628981e-01 0.580 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.068146e-01 0.684 0 0
Generation of second messenger molecules R-HSA-202433 1.666181e-01 0.778 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.244826e-01 0.649 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.244826e-01 0.649 0 0
Deadenylation of mRNA R-HSA-429947 2.529438e-01 0.597 0 0
ARMS-mediated activation R-HSA-170984 3.922424e-01 0.406 0 0
WNT mediated activation of DVL R-HSA-201688 3.922424e-01 0.406 0 0
ALK mutants bind TKIs R-HSA-9700645 3.922424e-01 0.406 0 0
MTF1 activates gene expression R-HSA-5660489 4.919335e-01 0.308 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.919335e-01 0.308 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.919335e-01 0.308 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.919335e-01 0.308 0 0
ATP sensitive Potassium channels R-HSA-1296025 4.919335e-01 0.308 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.919335e-01 0.308 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 4.919335e-01 0.308 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.919335e-01 0.308 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.919335e-01 0.308 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.938259e-01 0.713 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.256481e-01 0.901 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.426193e-01 0.615 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.426193e-01 0.615 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.324804e-01 0.634 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.240541e-02 1.084 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.622274e-01 0.441 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 3.622274e-01 0.441 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.622274e-01 0.441 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.622274e-01 0.441 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.673468e-01 0.776 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.800684e-01 0.553 0 0
Pexophagy R-HSA-9664873 4.310892e-01 0.365 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.310892e-01 0.365 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.659874e-01 0.575 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.172189e-01 0.663 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.924960e-01 0.406 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.924960e-01 0.406 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.301537e-01 0.638 0 0
HIV Transcription Elongation R-HSA-167169 2.832163e-01 0.548 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.832163e-01 0.548 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.832163e-01 0.548 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.687282e-01 0.571 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.687282e-01 0.571 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.687282e-01 0.571 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.687282e-01 0.571 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.687282e-01 0.571 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.928249e-01 0.715 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.392091e-01 0.470 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.392091e-01 0.470 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.186972e-01 0.497 0 0
Translation initiation complex formation R-HSA-72649 2.701137e-01 0.568 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.383098e-01 0.471 0 0
Signaling by Erythropoietin R-HSA-9006335 3.612412e-01 0.442 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.884648e-01 0.411 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 4.223814e-01 0.374 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.223814e-01 0.374 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.685705e-01 0.329 0 0
Signaling by APC mutants R-HSA-4839744 4.685705e-01 0.329 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.685705e-01 0.329 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.685705e-01 0.329 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.685705e-01 0.329 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.461663e-01 0.263 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.461663e-01 0.263 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.703801e-01 0.568 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.000036e-01 0.523 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.580464e-01 0.446 0 0
PI3K Cascade R-HSA-109704 3.336388e-01 0.477 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.517478e-01 0.345 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.517478e-01 0.345 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.104414e-01 0.508 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.274316e-01 0.485 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.053363e-01 0.392 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.855085e-01 0.544 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.045352e-01 0.297 0 0
Centrosome maturation R-HSA-380287 3.379108e-01 0.471 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.905299e-01 0.408 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.298435e-01 0.482 0 0
Meiotic synapsis R-HSA-1221632 3.838258e-01 0.416 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.838258e-01 0.416 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.775028e-01 0.423 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.086807e-01 0.389 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.501411e-01 0.456 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.090422e-01 0.388 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.090422e-01 0.388 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.012412e-01 0.397 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.807864e-01 0.419 0 0
Striated Muscle Contraction R-HSA-390522 4.705674e-01 0.327 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.871959e-01 0.312 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.084786e-01 0.294 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.388801e-01 0.269 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.388801e-01 0.269 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.388801e-01 0.269 0 0
Cam-PDE 1 activation R-HSA-111957 5.946131e-01 0.226 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.946131e-01 0.226 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.946131e-01 0.226 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.946131e-01 0.226 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.946131e-01 0.226 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.946131e-01 0.226 0 0
IRS-mediated signalling R-HSA-112399 4.510756e-01 0.346 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.195167e-01 0.377 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.918350e-01 0.308 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.341185e-01 0.272 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.715413e-01 0.243 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.169876e-01 0.287 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.619747e-01 0.250 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.095145e-01 0.293 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.567598e-01 0.254 0 0
Nucleosome assembly R-HSA-774815 5.514137e-01 0.259 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.514137e-01 0.259 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.350769e-01 0.272 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.350769e-01 0.272 0 0
HDACs deacetylate histones R-HSA-3214815 5.666717e-01 0.247 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.787956e-01 0.237 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.873570e-01 0.231 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.024869e-01 0.220 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.024869e-01 0.220 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.378906e-01 0.195 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.378906e-01 0.195 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.378906e-01 0.195 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.378906e-01 0.195 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.378906e-01 0.195 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.870010e-01 0.231 0 0
Downstream signal transduction R-HSA-186763 6.001912e-01 0.222 0 0
FGFR2 alternative splicing R-HSA-6803529 6.117747e-01 0.213 0 0
Notch-HLH transcription pathway R-HSA-350054 6.117747e-01 0.213 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.433259e-01 0.192 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.317109e-01 0.199 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.317109e-01 0.199 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.317109e-01 0.199 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.317109e-01 0.199 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.541464e-01 0.184 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.901905e-01 0.161 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.602834e-01 0.180 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.576246e-01 0.182 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.592282e-01 0.181 0 0
Phosphorylation of the APC/C R-HSA-176412 6.592282e-01 0.181 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.765503e-01 0.170 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.765503e-01 0.170 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.765503e-01 0.170 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.765503e-01 0.170 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.765503e-01 0.170 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.845719e-01 0.165 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.845719e-01 0.165 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.850701e-01 0.164 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.850701e-01 0.164 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.122429e-01 0.673 0 0
FOXO-mediated transcription R-HSA-9614085 2.659338e-01 0.575 0 0
RNA Polymerase III Transcription R-HSA-74158 3.580464e-01 0.446 0 0
DNA Double Strand Break Response R-HSA-5693606 3.420259e-01 0.466 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.454027e-01 0.351 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.619747e-01 0.250 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.619747e-01 0.250 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.517478e-01 0.345 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.517478e-01 0.345 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.413144e-01 0.850 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.473384e-01 0.189 0 0
Specification of the neural plate border R-HSA-9834899 1.381509e-01 0.860 0 0
HATs acetylate histones R-HSA-3214847 2.659338e-01 0.575 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.804794e-01 0.318 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.494225e-02 1.187 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.218301e-02 1.035 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.833070e-01 0.416 0 0
ESR-mediated signaling R-HSA-8939211 1.516307e-01 0.819 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.453785e-01 0.610 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.114272e-01 0.675 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.174670e-01 0.379 0 0
Signaling by EGFR R-HSA-177929 4.343194e-01 0.362 0 0
Prolonged ERK activation events R-HSA-169893 3.924960e-01 0.406 0 0
EPH-Ephrin signaling R-HSA-2682334 1.848514e-01 0.733 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.905299e-01 0.408 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.932605e-01 0.405 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.667977e-01 0.778 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.723871e-01 0.429 0 0
TGFBR3 expression R-HSA-9839394 2.740709e-01 0.562 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.379108e-01 0.471 0 0
Separation of Sister Chromatids R-HSA-2467813 3.209694e-01 0.494 0 0
EGFR downregulation R-HSA-182971 6.001912e-01 0.222 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.223814e-01 0.374 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.833070e-01 0.416 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.135083e-01 0.671 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.039440e-01 0.517 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.012412e-01 0.397 0 0
Signaling by ERBB2 R-HSA-1227986 5.007272e-01 0.300 0 0
Frs2-mediated activation R-HSA-170968 5.715413e-01 0.243 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.991280e-01 0.701 0 0
Mitotic Prometaphase R-HSA-68877 2.259548e-01 0.646 0 0
Formation of the posterior neural plate R-HSA-9832991 7.595764e-02 1.119 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.922424e-01 0.406 0 0
MAP2K and MAPK activation R-HSA-5674135 1.938259e-01 0.713 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.310892e-01 0.365 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.992643e-01 0.524 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.039440e-01 0.517 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.708427e-02 1.013 0 0
Apoptotic factor-mediated response R-HSA-111471 2.628981e-01 0.580 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.879835e-01 0.541 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.122673e-01 0.950 0 0
Meiosis R-HSA-1500620 1.735259e-01 0.761 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.766985e-01 0.322 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.865012e-02 1.104 0 0
Regulation of CDH11 function R-HSA-9762292 1.828304e-01 0.738 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.834673e-02 1.007 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.922424e-01 0.406 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.126854e-01 0.505 0 0
PI3K/AKT activation R-HSA-198203 4.310892e-01 0.365 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.102849e-01 0.677 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.519328e-01 0.818 0 0
Homology Directed Repair R-HSA-5693538 1.722641e-01 0.764 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.685705e-01 0.329 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.336466e-01 0.631 0 0
GPER1 signaling R-HSA-9634597 4.448554e-01 0.352 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.356652e-01 0.271 0 0
Peptide chain elongation R-HSA-156902 6.541464e-01 0.184 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.555411e-02 1.183 0 0
Myogenesis R-HSA-525793 4.871959e-01 0.312 0 0
Signalling to ERKs R-HSA-187687 5.127810e-01 0.290 0 0
Hedgehog 'off' state R-HSA-5610787 5.975035e-01 0.224 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.407715e-01 0.618 0 0
Signaling by RAS mutants R-HSA-6802949 2.687282e-01 0.571 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.850701e-01 0.164 0 0
TNF signaling R-HSA-75893 3.000036e-01 0.523 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.665035e-01 0.176 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.665035e-01 0.176 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.535400e-01 0.257 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.878325e-01 0.726 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.428166e-01 0.845 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.086807e-01 0.389 0 0
Adrenoceptors R-HSA-390696 1.295095e-01 0.888 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.136242e-01 0.945 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.113554e-01 0.507 0 0
Sodium/Proton exchangers R-HSA-425986 3.522385e-01 0.453 0 0
PKA activation R-HSA-163615 2.628981e-01 0.580 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.529438e-01 0.597 0 0
Unwinding of DNA R-HSA-176974 3.922424e-01 0.406 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.922424e-01 0.406 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.922424e-01 0.406 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.461663e-01 0.263 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.855085e-01 0.544 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 3.905299e-01 0.408 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.388801e-01 0.269 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.953864e-01 0.305 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.335503e-01 0.273 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.765503e-01 0.170 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.305912e-01 0.200 0 0
G-protein beta:gamma signalling R-HSA-397795 7.838151e-02 1.106 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.000464e-01 0.699 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.000464e-01 0.699 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.871959e-01 0.312 0 0
Rap1 signalling R-HSA-392517 1.381509e-01 0.860 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.707935e-01 0.567 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.379145e-01 0.471 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.172847e-01 0.499 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.992643e-01 0.524 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.845719e-01 0.165 0 0
TCR signaling R-HSA-202403 4.046840e-01 0.393 0 0
M Phase R-HSA-68886 2.676648e-01 0.572 0 0
Mitotic Prophase R-HSA-68875 8.720430e-02 1.059 0 0
IGF1R signaling cascade R-HSA-2428924 4.248225e-01 0.372 0 0
DAP12 signaling R-HSA-2424491 5.787956e-01 0.237 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.490612e-01 0.604 0 0
Meiotic recombination R-HSA-912446 3.502803e-01 0.456 0 0
Opioid Signalling R-HSA-111885 6.451324e-01 0.190 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.012856e-01 0.696 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.411842e-01 0.618 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.284929e-01 0.641 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.317319e-01 0.479 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.461663e-01 0.263 0 0
PTK6 Down-Regulation R-HSA-8849472 5.461663e-01 0.263 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.461663e-01 0.263 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.045352e-01 0.297 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.630219e-01 0.334 0 0
Tight junction interactions R-HSA-420029 4.630219e-01 0.334 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.953864e-01 0.305 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.927508e-01 0.406 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.715413e-01 0.243 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.125139e-01 0.385 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.787956e-01 0.237 0 0
HDL assembly R-HSA-8963896 6.024869e-01 0.220 0 0
Killing mechanisms R-HSA-9664420 6.592282e-01 0.181 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.592282e-01 0.181 0 0
PTK6 Expression R-HSA-8849473 6.765503e-01 0.170 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.850701e-01 0.164 0 0
G-protein mediated events R-HSA-112040 3.420259e-01 0.466 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.833070e-01 0.416 0 0
PTEN Regulation R-HSA-6807070 5.897844e-01 0.229 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.530025e-01 0.452 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 1.571743e-01 0.804 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.245901e-01 0.204 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.275800e-01 0.369 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.095145e-01 0.293 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.405764e-01 0.356 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.790350e-01 0.168 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.409543e-01 0.193 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.016084e-01 0.221 0 0
Nervous system development R-HSA-9675108 6.474367e-02 1.189 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.645427e-02 1.177 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.113634e-01 0.675 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.113554e-01 0.507 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.120672e-01 0.674 0 0
Polo-like kinase mediated events R-HSA-156711 2.628981e-01 0.580 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.919335e-01 0.308 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.461663e-01 0.263 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.517478e-01 0.345 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.905299e-01 0.408 0 0
Nuclear RNA decay R-HSA-9930044 4.490260e-01 0.348 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.946131e-01 0.226 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.946131e-01 0.226 0 0
Insulin receptor signalling cascade R-HSA-74751 5.645833e-01 0.248 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.378906e-01 0.195 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.378906e-01 0.195 0 0
Complex III assembly R-HSA-9865881 6.576246e-01 0.182 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.761779e-01 0.322 0 0
MTOR signalling R-HSA-165159 1.177327e-01 0.929 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.001912e-01 0.222 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.497840e-02 1.187 0 0
HIV Life Cycle R-HSA-162587 6.845248e-01 0.165 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.110883e-01 0.954 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.291821e-01 0.367 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.522385e-01 0.453 0 0
TBC/RABGAPs R-HSA-8854214 1.281532e-01 0.892 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.567616e-01 0.340 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.095145e-01 0.293 0 0
Signaling by WNT R-HSA-195721 5.820825e-01 0.235 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.832163e-01 0.548 0 0
PLC beta mediated events R-HSA-112043 3.775028e-01 0.423 0 0
Mitotic Anaphase R-HSA-68882 4.204987e-01 0.376 0 0
Semaphorin interactions R-HSA-373755 1.848060e-01 0.733 0 0
Signaling by FGFR4 R-HSA-5654743 6.811639e-01 0.167 0 0
Cell Cycle, Mitotic R-HSA-69278 1.013666e-01 0.994 0 0
Ca-dependent events R-HSA-111996 2.080790e-01 0.682 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 4.223814e-01 0.374 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.409543e-01 0.193 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.592282e-01 0.181 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.863936e-01 0.232 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.863936e-01 0.232 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.294345e-01 0.201 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.838151e-02 1.106 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.471853e-01 0.262 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.369418e-02 1.077 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.535400e-01 0.257 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.952041e-02 1.158 0 0
Post NMDA receptor activation events R-HSA-438064 4.006580e-01 0.397 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.873570e-01 0.231 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.052282e-01 0.978 0 0
Signaling by VEGF R-HSA-194138 1.197983e-01 0.922 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.433717e-01 0.614 0 0
Cell junction organization R-HSA-446728 3.627146e-01 0.440 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.871959e-01 0.312 0 0
Regulation of insulin secretion R-HSA-422356 6.841082e-01 0.165 0 0
Membrane Trafficking R-HSA-199991 1.450347e-01 0.839 0 0
Ub-specific processing proteases R-HSA-5689880 5.000807e-01 0.301 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.172847e-01 0.499 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.503947e-01 0.823 0 0
Calmodulin induced events R-HSA-111933 2.162874e-01 0.665 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.369496e-01 0.196 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.181443e-01 0.286 0 0
Signaling by NTRKs R-HSA-166520 3.291390e-01 0.483 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.405777e-01 0.267 0 0
Signal Transduction R-HSA-162582 8.088197e-02 1.092 1 0
Rab regulation of trafficking R-HSA-9007101 7.334168e-02 1.135 0 0
Diseases of programmed cell death R-HSA-9645723 6.541464e-01 0.184 0 0
S Phase R-HSA-69242 5.988764e-01 0.223 0 0
PI Metabolism R-HSA-1483255 9.558628e-02 1.020 0 0
Cell-Cell communication R-HSA-1500931 3.277974e-01 0.484 0 0
Regulation of PTEN localization R-HSA-8948747 1.053050e-01 0.978 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 3.632642e-01 0.440 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.484232e-01 0.828 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.217612e-01 0.914 0 0
MET interacts with TNS proteins R-HSA-8875513 4.312238e-01 0.365 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.312238e-01 0.365 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.312238e-01 0.365 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.522385e-01 0.453 0 0
Co-stimulation by ICOS R-HSA-9927354 3.522385e-01 0.453 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.628981e-01 0.580 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.922424e-01 0.406 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 4.919335e-01 0.308 0 0
Transmission across Electrical Synapses R-HSA-112307 4.919335e-01 0.308 0 0
CaM pathway R-HSA-111997 2.162874e-01 0.665 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.310892e-01 0.365 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.172847e-01 0.499 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.924960e-01 0.406 0 0
Phase 4 - resting membrane potential R-HSA-5576886 3.924960e-01 0.406 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.832163e-01 0.548 0 0
Disorders of Developmental Biology R-HSA-9675151 4.223814e-01 0.374 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.461663e-01 0.263 0 0
Reelin signalling pathway R-HSA-8866376 5.461663e-01 0.263 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.461663e-01 0.263 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.306373e-01 0.481 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.903969e-01 0.537 0 0
Signaling by AXIN mutants R-HSA-4839735 5.045352e-01 0.297 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.045352e-01 0.297 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.490260e-01 0.348 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.388801e-01 0.269 0 0
NGF-independant TRKA activation R-HSA-187024 5.946131e-01 0.226 0 0
Phosphorylation of Emi1 R-HSA-176417 5.946131e-01 0.226 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.946131e-01 0.226 0 0
Synthesis of PS R-HSA-1483101 5.946131e-01 0.226 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.715413e-01 0.243 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.715413e-01 0.243 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.715413e-01 0.243 0 0
cGMP effects R-HSA-418457 6.024869e-01 0.220 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.378906e-01 0.195 0 0
DNA Repair R-HSA-73894 6.353327e-01 0.197 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.304409e-01 0.200 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.602495e-01 0.180 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.592282e-01 0.181 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.765503e-01 0.170 0 0
Deubiquitination R-HSA-5688426 3.846915e-01 0.415 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.220613e-01 0.492 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.077943e-01 0.967 0 0
Signaling by FGFR in disease R-HSA-1226099 3.241127e-01 0.489 0 0
Cellular response to heat stress R-HSA-3371556 5.585267e-01 0.253 0 0
GPVI-mediated activation cascade R-HSA-114604 3.580464e-01 0.446 0 0
Heme signaling R-HSA-9707616 6.745936e-01 0.171 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.686946e-01 0.571 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.922763e-01 0.716 0 0
G2/M Transition R-HSA-69275 3.754384e-01 0.425 0 0
DAG and IP3 signaling R-HSA-1489509 2.530835e-01 0.597 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.971670e-02 1.157 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.526772e-01 0.344 0 0
G2/M Checkpoints R-HSA-69481 1.884164e-01 0.725 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.936392e-01 0.405 0 0
Cellular Senescence R-HSA-2559583 4.823049e-01 0.317 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.384577e-01 0.358 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.317109e-01 0.199 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.007272e-01 0.300 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.172189e-01 0.663 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.776476e-01 0.750 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.838151e-02 1.106 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.918350e-01 0.308 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.765503e-01 0.170 0 0
Programmed Cell Death R-HSA-5357801 3.268647e-01 0.486 0 0
Aquaporin-mediated transport R-HSA-445717 5.169876e-01 0.287 0 0
Reproduction R-HSA-1474165 2.214359e-01 0.655 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.922424e-01 0.406 0 0
Signal attenuation R-HSA-74749 4.310892e-01 0.365 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.446546e-01 0.611 0 0
TRP channels R-HSA-3295583 4.871959e-01 0.312 0 0
tRNA processing in the nucleus R-HSA-6784531 5.330642e-01 0.273 0 0
Long-term potentiation R-HSA-9620244 6.790350e-01 0.168 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.705737e-01 0.568 0 0
Oncogene Induced Senescence R-HSA-2559585 6.967816e-01 0.157 0 0
Signaling by TGFB family members R-HSA-9006936 2.851122e-01 0.545 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.425170e-01 0.846 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.284929e-01 0.641 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.696315e-01 0.770 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.561900e-01 0.806 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.992643e-01 0.524 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.481822e-01 0.829 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.461663e-01 0.263 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.045352e-01 0.297 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.086807e-01 0.389 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.630219e-01 0.334 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.630219e-01 0.334 0 0
Signaling by LTK R-HSA-9842663 5.388801e-01 0.269 0 0
Pervasive developmental disorders R-HSA-9005895 5.388801e-01 0.269 0 0
Disorders of Nervous System Development R-HSA-9697154 5.388801e-01 0.269 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.388801e-01 0.269 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.946131e-01 0.226 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.024869e-01 0.220 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.765503e-01 0.170 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.343194e-01 0.362 0 0
Signaling by PTK6 R-HSA-8848021 4.090422e-01 0.388 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.090422e-01 0.388 0 0
Muscle contraction R-HSA-397014 6.928197e-01 0.159 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.172847e-01 0.499 0 0
Nephrin family interactions R-HSA-373753 3.126854e-01 0.505 0 0
Sensory processing of sound R-HSA-9659379 3.939834e-01 0.405 0 0
G alpha (z) signalling events R-HSA-418597 5.666717e-01 0.247 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.094782e-01 0.961 0 0
Maturation of spike protein R-HSA-9683686 4.310892e-01 0.365 0 0
Smooth Muscle Contraction R-HSA-445355 5.329683e-01 0.273 0 0
mTORC1-mediated signalling R-HSA-166208 6.117747e-01 0.213 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.216877e-01 0.206 0 0
Regulation of BACH1 activity R-HSA-9708530 6.592282e-01 0.181 0 0
Cardiogenesis R-HSA-9733709 6.409543e-01 0.193 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.084786e-01 0.294 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.901856e-01 0.310 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.143505e-01 0.289 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.001912e-01 0.222 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.120672e-01 0.674 0 0
Kinesins R-HSA-983189 2.433717e-01 0.614 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.135777e-01 0.383 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.352024e-01 0.197 0 0
Apoptosis R-HSA-109581 1.733812e-01 0.761 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.679032e-01 0.246 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.871897e-01 0.542 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.284929e-01 0.641 0 0
DSCAM interactions R-HSA-376172 3.632642e-01 0.440 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.312238e-01 0.365 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.312238e-01 0.365 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.628981e-01 0.580 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.922424e-01 0.406 0 0
Sensory perception of sour taste R-HSA-9729555 4.919335e-01 0.308 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.126854e-01 0.505 0 0
G0 and Early G1 R-HSA-1538133 2.611673e-01 0.583 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.310892e-01 0.365 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.946131e-01 0.226 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.619747e-01 0.250 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.619747e-01 0.250 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.378906e-01 0.195 0 0
snRNP Assembly R-HSA-191859 6.304409e-01 0.200 0 0
Metabolism of non-coding RNA R-HSA-194441 6.304409e-01 0.200 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.576246e-01 0.182 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.765503e-01 0.170 0 0
VLDL clearance R-HSA-8964046 6.765503e-01 0.170 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.788946e-01 0.168 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.850701e-01 0.164 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.194921e-01 0.284 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.078347e-01 0.967 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.235037e-01 0.908 0 0
Glycolysis R-HSA-70171 1.952876e-01 0.709 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.743384e-02 1.058 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.332695e-01 0.273 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.024869e-01 0.220 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.787955e-01 0.168 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.800684e-01 0.553 0 0
Nuclear import of Rev protein R-HSA-180746 3.186972e-01 0.497 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.378906e-01 0.195 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.317109e-01 0.199 0 0
Signaling by ALK in cancer R-HSA-9700206 8.743384e-02 1.058 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.044288e-01 0.219 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.800684e-01 0.553 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.317109e-01 0.199 0 0
Signaling by ALK R-HSA-201556 5.925540e-01 0.227 0 0
Inositol phosphate metabolism R-HSA-1483249 6.414812e-01 0.193 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.312238e-01 0.365 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.312238e-01 0.365 0 0
Dopamine receptors R-HSA-390651 4.919335e-01 0.308 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.919335e-01 0.308 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.343194e-01 0.362 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.567616e-01 0.340 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 5.946131e-01 0.226 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.946131e-01 0.226 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.715413e-01 0.243 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.567598e-01 0.254 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.873570e-01 0.231 0 0
NADPH regeneration R-HSA-389542 6.378906e-01 0.195 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.378906e-01 0.195 0 0
Metal ion SLC transporters R-HSA-425410 6.044288e-01 0.219 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.409543e-01 0.193 0 0
Activation of TRKA receptors R-HSA-187015 6.765503e-01 0.170 0 0
Interleukin-7 signaling R-HSA-1266695 2.740709e-01 0.562 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.554494e-01 0.808 0 0
Formation of the nephric duct R-HSA-9830364 6.790350e-01 0.168 0 0
FLT3 Signaling R-HSA-9607240 9.834673e-02 1.007 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.283296e-01 0.892 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.622274e-01 0.441 0 0
Glucose metabolism R-HSA-70326 3.145887e-01 0.502 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.946131e-01 0.226 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.946131e-01 0.226 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.873570e-01 0.231 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.024869e-01 0.220 0 0
Lipid particle organization R-HSA-8964572 6.378906e-01 0.195 0 0
Nef and signal transduction R-HSA-164944 6.378906e-01 0.195 0 0
LDL clearance R-HSA-8964038 6.117747e-01 0.213 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.317109e-01 0.199 0 0
CHL1 interactions R-HSA-447041 6.765503e-01 0.170 0 0
Nephron development R-HSA-9831926 2.628981e-01 0.580 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.924960e-01 0.406 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.924960e-01 0.406 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.632104e-01 0.440 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.174670e-01 0.379 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.461663e-01 0.263 0 0
Maturation of nucleoprotein R-HSA-9694631 5.084786e-01 0.294 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.873570e-01 0.231 0 0
Neurofascin interactions R-HSA-447043 6.378906e-01 0.195 0 0
Growth hormone receptor signaling R-HSA-982772 6.352024e-01 0.197 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.850701e-01 0.164 0 0
OAS antiviral response R-HSA-8983711 5.388801e-01 0.269 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.619747e-01 0.250 0 0
Maturation of nucleoprotein R-HSA-9683610 5.715413e-01 0.243 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.288612e-01 0.201 0 0
Signaling by Leptin R-HSA-2586552 4.310892e-01 0.365 0 0
Activation of BH3-only proteins R-HSA-114452 5.787956e-01 0.237 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.736060e-01 0.172 0 0
Interleukin-37 signaling R-HSA-9008059 5.787956e-01 0.237 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 5.706419e-01 0.244 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.117747e-01 0.213 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.461663e-01 0.263 0 0
G1 Phase R-HSA-69236 6.972356e-01 0.157 0 0
Cyclin D associated events in G1 R-HSA-69231 6.972356e-01 0.157 0 0
Amine ligand-binding receptors R-HSA-375280 6.972356e-01 0.157 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.994353e-01 0.155 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.994353e-01 0.155 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.994353e-01 0.155 0 0
IRE1alpha activates chaperones R-HSA-381070 7.016793e-01 0.154 0 0
Cell-cell junction organization R-HSA-421270 7.057830e-01 0.151 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.092807e-01 0.149 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.092807e-01 0.149 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.092807e-01 0.149 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.092807e-01 0.149 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.092807e-01 0.149 0 0
phospho-PLA2 pathway R-HSA-111995 7.110846e-01 0.148 0 0
Formation of annular gap junctions R-HSA-196025 7.110846e-01 0.148 0 0
MET receptor recycling R-HSA-8875656 7.110846e-01 0.148 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.110846e-01 0.148 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.110846e-01 0.148 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.110846e-01 0.148 0 0
Regulation by c-FLIP R-HSA-3371378 7.110846e-01 0.148 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.110846e-01 0.148 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.110846e-01 0.148 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.110846e-01 0.148 0 0
Dimerization of procaspase-8 R-HSA-69416 7.110846e-01 0.148 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.110846e-01 0.148 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.110846e-01 0.148 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.110846e-01 0.148 0 0
RSK activation R-HSA-444257 7.110846e-01 0.148 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.127397e-01 0.147 0 0
Signaling by FGFR3 R-HSA-5654741 7.127397e-01 0.147 0 0
Signaling by Insulin receptor R-HSA-74752 7.128978e-01 0.147 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.128978e-01 0.147 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.139424e-01 0.146 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.139424e-01 0.146 0 0
FLT3 signaling in disease R-HSA-9682385 7.139424e-01 0.146 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.187418e-01 0.143 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.188337e-01 0.143 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.188337e-01 0.143 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.188337e-01 0.143 0 0
MAPK family signaling cascades R-HSA-5683057 7.254499e-01 0.139 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.270831e-01 0.138 0 0
Ion homeostasis R-HSA-5578775 7.272126e-01 0.138 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.276743e-01 0.138 0 0
Signaling by TGFBR3 R-HSA-9839373 7.276743e-01 0.138 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.319135e-01 0.136 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.319135e-01 0.136 0 0
Mismatch Repair R-HSA-5358508 7.319135e-01 0.136 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.319135e-01 0.136 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.319135e-01 0.136 0 0
Platelet sensitization by LDL R-HSA-432142 7.319135e-01 0.136 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.319135e-01 0.136 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.360792e-01 0.133 0 0
Adherens junctions interactions R-HSA-418990 7.369768e-01 0.133 0 0
Telomere Extension By Telomerase R-HSA-171319 7.372445e-01 0.132 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.372445e-01 0.132 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.372445e-01 0.132 0 0
Kidney development R-HSA-9830369 7.404452e-01 0.131 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.409583e-01 0.130 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.419336e-01 0.130 0 0
Gap junction degradation R-HSA-190873 7.419336e-01 0.130 0 0
CASP8 activity is inhibited R-HSA-5218900 7.419336e-01 0.130 0 0
Calcineurin activates NFAT R-HSA-2025928 7.419336e-01 0.130 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.419336e-01 0.130 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.419336e-01 0.130 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.419336e-01 0.130 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.419336e-01 0.130 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.419336e-01 0.130 0 0
Interleukin-1 processing R-HSA-448706 7.419336e-01 0.130 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.419336e-01 0.130 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.419336e-01 0.130 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.419336e-01 0.130 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.420403e-01 0.130 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.449022e-01 0.128 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.449022e-01 0.128 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.460973e-01 0.127 0 0
MET promotes cell motility R-HSA-8875878 7.460973e-01 0.127 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.460973e-01 0.127 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.471856e-01 0.127 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.478431e-01 0.126 0 0
Transcription of the HIV genome R-HSA-167172 7.524192e-01 0.124 0 0
PCP/CE pathway R-HSA-4086400 7.526270e-01 0.123 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.526292e-01 0.123 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.530296e-01 0.123 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.530296e-01 0.123 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.530296e-01 0.123 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.530296e-01 0.123 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.530296e-01 0.123 0 0
DNA methylation R-HSA-5334118 7.546865e-01 0.122 0 0
Late endosomal microautophagy R-HSA-9615710 7.546865e-01 0.122 0 0
DARPP-32 events R-HSA-180024 7.546865e-01 0.122 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.546865e-01 0.122 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.546865e-01 0.122 0 0
Platelet calcium homeostasis R-HSA-418360 7.546865e-01 0.122 0 0
Glucagon-type ligand receptors R-HSA-420092 7.546865e-01 0.122 0 0
Eukaryotic Translation Termination R-HSA-72764 7.550138e-01 0.122 0 0
Autophagy R-HSA-9612973 7.557648e-01 0.122 0 0
NGF-stimulated transcription R-HSA-9031628 7.558406e-01 0.122 0 0
Stabilization of p53 R-HSA-69541 7.611055e-01 0.119 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.611055e-01 0.119 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.619876e-01 0.118 0 0
Selective autophagy R-HSA-9663891 7.639057e-01 0.117 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.687247e-01 0.114 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.694902e-01 0.114 0 0
CASP4 inflammasome assembly R-HSA-9948001 7.694902e-01 0.114 0 0
2-LTR circle formation R-HSA-164843 7.694902e-01 0.114 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.694902e-01 0.114 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.694902e-01 0.114 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.694902e-01 0.114 0 0
Interleukin-27 signaling R-HSA-9020956 7.694902e-01 0.114 0 0
Cellular response to starvation R-HSA-9711097 7.711125e-01 0.113 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.711831e-01 0.113 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.711831e-01 0.113 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.711831e-01 0.113 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.711831e-01 0.113 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.726946e-01 0.112 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.726946e-01 0.112 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.726946e-01 0.112 0 0
Signaling by NODAL R-HSA-1181150 7.726946e-01 0.112 0 0
Negative regulation of MET activity R-HSA-6807004 7.726946e-01 0.112 0 0
Protein hydroxylation R-HSA-9629569 7.726946e-01 0.112 0 0
Signaling by FGFR2 R-HSA-5654738 7.741069e-01 0.111 0 0
PKR-mediated signaling R-HSA-9833482 7.741069e-01 0.111 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.751688e-01 0.111 0 0
Signaling by Interleukins R-HSA-449147 7.753655e-01 0.110 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.754148e-01 0.110 0 0
Gastrulation R-HSA-9758941 7.762139e-01 0.110 0 0
Macroautophagy R-HSA-1632852 7.817349e-01 0.107 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.817657e-01 0.107 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.841979e-01 0.106 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.857261e-01 0.105 0 0
Budding and maturation of HIV virion R-HSA-162588 7.867604e-01 0.104 0 0
MAP kinase activation R-HSA-450294 7.889273e-01 0.103 0 0
Maturation of spike protein R-HSA-9694548 7.890388e-01 0.103 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.890388e-01 0.103 0 0
Influenza Infection R-HSA-168255 7.901157e-01 0.102 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.909777e-01 0.102 0 0
Signalling to RAS R-HSA-167044 7.909777e-01 0.102 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.909777e-01 0.102 0 0
ERK/MAPK targets R-HSA-198753 7.909777e-01 0.102 0 0
Stimuli-sensing channels R-HSA-2672351 7.928164e-01 0.101 0 0
L1CAM interactions R-HSA-373760 7.933822e-01 0.101 0 0
ChREBP activates metabolic gene expression R-HSA-163765 7.941058e-01 0.100 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.941058e-01 0.100 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.941058e-01 0.100 0 0
LGI-ADAM interactions R-HSA-5682910 7.941058e-01 0.100 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.941058e-01 0.100 0 0
Synthesis of PI R-HSA-1483226 7.941058e-01 0.100 0 0
Bicarbonate transporters R-HSA-425381 7.941058e-01 0.100 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.941058e-01 0.100 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.941058e-01 0.100 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.941058e-01 0.100 0 0
PECAM1 interactions R-HSA-210990 7.941058e-01 0.100 0 0
Suppression of apoptosis R-HSA-9635465 7.941058e-01 0.100 0 0
G1/S Transition R-HSA-69206 7.942682e-01 0.100 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.963378e-01 0.099 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.963378e-01 0.099 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.963378e-01 0.099 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.963378e-01 0.099 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.982143e-01 0.098 0 0
Transmission across Chemical Synapses R-HSA-112315 7.990814e-01 0.097 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.998913e-01 0.097 0 0
Signaling by WNT in cancer R-HSA-4791275 8.014476e-01 0.096 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.019930e-01 0.096 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.019930e-01 0.096 0 0
Translation of Structural Proteins R-HSA-9683701 8.019930e-01 0.096 0 0
Vesicle-mediated transport R-HSA-5653656 8.022055e-01 0.096 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.055099e-01 0.094 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.067922e-01 0.093 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.079496e-01 0.093 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.079496e-01 0.093 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.079496e-01 0.093 0 0
Assembly Of The HIV Virion R-HSA-175474 8.079496e-01 0.093 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.092996e-01 0.092 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.092996e-01 0.092 0 0
Selenocysteine synthesis R-HSA-2408557 8.098322e-01 0.092 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.104094e-01 0.091 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.142945e-01 0.089 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.152757e-01 0.089 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.152757e-01 0.089 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.160940e-01 0.088 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.160940e-01 0.088 0 0
Integration of provirus R-HSA-162592 8.160940e-01 0.088 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.160940e-01 0.088 0 0
NF-kB is activated and signals survival R-HSA-209560 8.160940e-01 0.088 0 0
ERKs are inactivated R-HSA-202670 8.160940e-01 0.088 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.160940e-01 0.088 0 0
Sodium/Calcium exchangers R-HSA-425561 8.160940e-01 0.088 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.165894e-01 0.088 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.184479e-01 0.087 0 0
Neuronal System R-HSA-112316 8.185076e-01 0.087 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.204895e-01 0.086 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.236819e-01 0.084 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.236819e-01 0.084 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.236819e-01 0.084 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.236819e-01 0.084 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.236819e-01 0.084 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.236819e-01 0.084 0 0
Viral mRNA Translation R-HSA-192823 8.259130e-01 0.083 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.282773e-01 0.082 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.282773e-01 0.082 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.282773e-01 0.082 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.282773e-01 0.082 0 0
Signaling by Hedgehog R-HSA-5358351 8.307926e-01 0.081 0 0
Chromosome Maintenance R-HSA-73886 8.313166e-01 0.080 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.313898e-01 0.080 0 0
Developmental Cell Lineages R-HSA-9734767 8.338047e-01 0.079 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.340809e-01 0.079 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.357352e-01 0.078 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.357352e-01 0.078 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.357352e-01 0.078 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.357352e-01 0.078 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.357352e-01 0.078 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.357352e-01 0.078 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.357352e-01 0.078 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.357352e-01 0.078 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.357352e-01 0.078 0 0
Regulation of IFNG signaling R-HSA-877312 8.357352e-01 0.078 0 0
Synthesis of GDP-mannose R-HSA-446205 8.357352e-01 0.078 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.357352e-01 0.078 0 0
Estrogen biosynthesis R-HSA-193144 8.357352e-01 0.078 0 0
Interleukin-35 Signalling R-HSA-8984722 8.357352e-01 0.078 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.357352e-01 0.078 0 0
Interleukin-15 signaling R-HSA-8983432 8.357352e-01 0.078 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.370146e-01 0.077 0 0
DAP12 interactions R-HSA-2172127 8.370146e-01 0.077 0 0
Signaling by NOTCH3 R-HSA-9012852 8.372235e-01 0.077 0 0
Carnitine shuttle R-HSA-200425 8.382457e-01 0.077 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.393713e-01 0.076 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.404861e-01 0.075 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.404861e-01 0.075 0 0
RAF activation R-HSA-5673000 8.404861e-01 0.075 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.404861e-01 0.075 0 0
Signal amplification R-HSA-392518 8.404861e-01 0.075 0 0
Translation of Structural Proteins R-HSA-9694635 8.425958e-01 0.074 0 0
Cardiac conduction R-HSA-5576891 8.440757e-01 0.074 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.449230e-01 0.073 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.468049e-01 0.072 0 0
Signaling by FGFR1 R-HSA-5654736 8.468049e-01 0.072 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.474732e-01 0.072 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.474732e-01 0.072 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.480585e-01 0.072 0 0
RNA Polymerase I Transcription R-HSA-73864 8.507572e-01 0.070 0 0
Host Interactions of HIV factors R-HSA-162909 8.514011e-01 0.070 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.517110e-01 0.070 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.517110e-01 0.070 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.517110e-01 0.070 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.519364e-01 0.070 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.519364e-01 0.070 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.519364e-01 0.070 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.528860e-01 0.069 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.532797e-01 0.069 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.532797e-01 0.069 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.532797e-01 0.069 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.532797e-01 0.069 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.532797e-01 0.069 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.532797e-01 0.069 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.532797e-01 0.069 0 0
Regulated Necrosis R-HSA-5218859 8.566145e-01 0.067 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.585733e-01 0.066 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.637233e-01 0.064 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.637233e-01 0.064 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.637233e-01 0.064 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.641463e-01 0.063 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.644749e-01 0.063 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.644749e-01 0.063 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.644749e-01 0.063 0 0
Recycling pathway of L1 R-HSA-437239 8.666930e-01 0.062 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.666930e-01 0.062 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.679317e-01 0.062 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.689513e-01 0.061 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.689513e-01 0.061 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.689513e-01 0.061 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.689513e-01 0.061 0 0
Hydrolysis of LPC R-HSA-1483115 8.689513e-01 0.061 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.689513e-01 0.061 0 0
Signal regulatory protein family interactions R-HSA-391160 8.689513e-01 0.061 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.689513e-01 0.061 0 0
Physiological factors R-HSA-5578768 8.689513e-01 0.061 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.689513e-01 0.061 0 0
Regulation of KIT signaling R-HSA-1433559 8.689513e-01 0.061 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.689513e-01 0.061 0 0
Zinc transporters R-HSA-435354 8.689513e-01 0.061 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.689513e-01 0.061 0 0
Mitochondrial biogenesis R-HSA-1592230 8.715418e-01 0.060 0 0
Interleukin-17 signaling R-HSA-448424 8.723048e-01 0.059 0 0
Extension of Telomeres R-HSA-180786 8.727793e-01 0.059 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.740731e-01 0.058 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.756181e-01 0.058 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.756181e-01 0.058 0 0
Metalloprotease DUBs R-HSA-5689901 8.756181e-01 0.058 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.756181e-01 0.058 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.756181e-01 0.058 0 0
Integration of energy metabolism R-HSA-163685 8.789239e-01 0.056 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.829498e-01 0.054 0 0
Erythropoietin activates RAS R-HSA-9027284 8.829498e-01 0.054 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.829498e-01 0.054 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.829498e-01 0.054 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.829498e-01 0.054 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.829498e-01 0.054 0 0
p75NTR signals via NF-kB R-HSA-193639 8.829498e-01 0.054 0 0
Translesion synthesis by REV1 R-HSA-110312 8.829498e-01 0.054 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.829498e-01 0.054 0 0
p38MAPK events R-HSA-171007 8.829498e-01 0.054 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.829498e-01 0.054 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 8.829498e-01 0.054 0 0
Protein methylation R-HSA-8876725 8.829498e-01 0.054 0 0
DNA Damage Reversal R-HSA-73942 8.829498e-01 0.054 0 0
DNA Damage Bypass R-HSA-73893 8.837941e-01 0.054 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.861901e-01 0.052 0 0
Signaling by BMP R-HSA-201451 8.861901e-01 0.052 0 0
Cristae formation R-HSA-8949613 8.861901e-01 0.052 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.875230e-01 0.052 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.908419e-01 0.050 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.916049e-01 0.050 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.921930e-01 0.050 0 0
Translesion synthesis by POLI R-HSA-5656121 8.954537e-01 0.048 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.954537e-01 0.048 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.954537e-01 0.048 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.954537e-01 0.048 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.954537e-01 0.048 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.954537e-01 0.048 0 0
Differentiation of T cells R-HSA-9945266 8.954537e-01 0.048 0 0
Negative regulation of FLT3 R-HSA-9706369 8.954537e-01 0.048 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.954537e-01 0.048 0 0
Virus Assembly and Release R-HSA-168268 8.954537e-01 0.048 0 0
Pyroptosis R-HSA-5620971 8.959236e-01 0.048 0 0
Insulin receptor recycling R-HSA-77387 8.959236e-01 0.048 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.963622e-01 0.048 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.987149e-01 0.046 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.989516e-01 0.046 0 0
HSF1-dependent transactivation R-HSA-3371571 8.989516e-01 0.046 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.990144e-01 0.046 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.990144e-01 0.046 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.990144e-01 0.046 0 0
Signaling by ERBB4 R-HSA-1236394 8.993953e-01 0.046 0 0
Potential therapeutics for SARS R-HSA-9679191 9.011376e-01 0.045 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.015202e-01 0.045 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.021686e-01 0.045 0 0
mRNA Capping R-HSA-72086 9.048772e-01 0.043 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.048772e-01 0.043 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.048772e-01 0.043 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.048772e-01 0.043 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.048772e-01 0.043 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.058555e-01 0.043 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.058555e-01 0.043 0 0
G alpha (s) signalling events R-HSA-418555 9.065239e-01 0.043 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.066225e-01 0.043 0 0
Translesion synthesis by POLK R-HSA-5655862 9.066225e-01 0.043 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.066225e-01 0.043 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.066225e-01 0.043 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.066225e-01 0.043 0 0
Passive transport by Aquaporins R-HSA-432047 9.066225e-01 0.043 0 0
Response to metal ions R-HSA-5660526 9.066225e-01 0.043 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.066312e-01 0.043 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.066312e-01 0.043 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.094647e-01 0.041 0 0
Nucleotide Excision Repair R-HSA-5696398 9.099196e-01 0.041 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.108442e-01 0.041 0 0
Activation of the pre-replicative complex R-HSA-68962 9.131063e-01 0.039 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.131063e-01 0.039 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.137238e-01 0.039 0 0
Intra-Golgi traffic R-HSA-6811438 9.137238e-01 0.039 0 0
Platelet homeostasis R-HSA-418346 9.145728e-01 0.039 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.149176e-01 0.039 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.165987e-01 0.038 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.165987e-01 0.038 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.165987e-01 0.038 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.165987e-01 0.038 0 0
Catecholamine biosynthesis R-HSA-209905 9.165987e-01 0.038 0 0
Choline catabolism R-HSA-6798163 9.165987e-01 0.038 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.165987e-01 0.038 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.184196e-01 0.037 0 0
Gene Silencing by RNA R-HSA-211000 9.190199e-01 0.037 0 0
Activation of GABAB receptors R-HSA-991365 9.203225e-01 0.036 0 0
GABA B receptor activation R-HSA-977444 9.203225e-01 0.036 0 0
PPARA activates gene expression R-HSA-1989781 9.208599e-01 0.036 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.213996e-01 0.036 0 0
Signaling by FGFR R-HSA-190236 9.234631e-01 0.035 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.241205e-01 0.034 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.241205e-01 0.034 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.252482e-01 0.034 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.255097e-01 0.034 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.255097e-01 0.034 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.255097e-01 0.034 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.255097e-01 0.034 0 0
HIV Infection R-HSA-162906 9.255355e-01 0.034 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.275984e-01 0.033 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.275984e-01 0.033 0 0
DNA strand elongation R-HSA-69190 9.275984e-01 0.033 0 0
Neurotransmitter release cycle R-HSA-112310 9.287408e-01 0.032 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.294606e-01 0.032 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.307304e-01 0.031 0 0
Signaling by MET R-HSA-6806834 9.307304e-01 0.031 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.311817e-01 0.031 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.311817e-01 0.031 0 0
RMTs methylate histone arginines R-HSA-3214858 9.321546e-01 0.031 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.334690e-01 0.030 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.334690e-01 0.030 0 0
Regulation of signaling by CBL R-HSA-912631 9.334690e-01 0.030 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.334690e-01 0.030 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.334690e-01 0.030 0 0
The NLRP3 inflammasome R-HSA-844456 9.334690e-01 0.030 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.334690e-01 0.030 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.334690e-01 0.030 0 0
Other interleukin signaling R-HSA-449836 9.334690e-01 0.030 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.334690e-01 0.030 0 0
Interferon gamma signaling R-HSA-877300 9.341595e-01 0.030 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.350157e-01 0.029 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.350181e-01 0.029 0 0
Cilium Assembly R-HSA-5617833 9.351940e-01 0.029 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.354933e-01 0.029 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.374432e-01 0.028 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.383858e-01 0.028 0 0
rRNA processing R-HSA-72312 9.388957e-01 0.027 0 0
Dual incision in TC-NER R-HSA-6782135 9.391336e-01 0.027 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.397850e-01 0.027 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.397850e-01 0.027 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.397850e-01 0.027 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.405782e-01 0.027 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.405782e-01 0.027 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.405782e-01 0.027 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.405782e-01 0.027 0 0
Creatine metabolism R-HSA-71288 9.405782e-01 0.027 0 0
Formation of definitive endoderm R-HSA-9823730 9.405782e-01 0.027 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.405782e-01 0.027 0 0
Signal transduction by L1 R-HSA-445144 9.405782e-01 0.027 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.413565e-01 0.026 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.413565e-01 0.026 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.423483e-01 0.026 0 0
Hedgehog 'on' state R-HSA-5632684 9.424931e-01 0.026 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.424931e-01 0.026 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.428925e-01 0.026 0 0
Regulation of beta-cell development R-HSA-186712 9.435029e-01 0.025 0 0
Signaling by NOTCH2 R-HSA-1980145 9.451216e-01 0.025 0 0
eNOS activation R-HSA-203615 9.451216e-01 0.025 0 0
Mitophagy R-HSA-5205647 9.451216e-01 0.025 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.451216e-01 0.025 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.451216e-01 0.025 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.451216e-01 0.025 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.465296e-01 0.024 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.468945e-01 0.024 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.469282e-01 0.024 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.469282e-01 0.024 0 0
G-protein activation R-HSA-202040 9.469282e-01 0.024 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.469282e-01 0.024 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.469282e-01 0.024 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.469282e-01 0.024 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.469282e-01 0.024 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.469282e-01 0.024 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.469282e-01 0.024 0 0
Basigin interactions R-HSA-210991 9.469282e-01 0.024 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.471781e-01 0.024 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.475838e-01 0.023 0 0
GABA receptor activation R-HSA-977443 9.475838e-01 0.023 0 0
tRNA Aminoacylation R-HSA-379724 9.475838e-01 0.023 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.490174e-01 0.023 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.490174e-01 0.023 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.499745e-01 0.022 0 0
Ca2+ pathway R-HSA-4086398 9.499745e-01 0.022 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.500057e-01 0.022 0 0
PERK regulates gene expression R-HSA-381042 9.500057e-01 0.022 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.526000e-01 0.021 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.526000e-01 0.021 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.526000e-01 0.021 0 0
Glutathione synthesis and recycling R-HSA-174403 9.526000e-01 0.021 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.526000e-01 0.021 0 0
Triglyceride catabolism R-HSA-163560 9.544730e-01 0.020 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.544730e-01 0.020 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.544730e-01 0.020 0 0
Signaling by PDGF R-HSA-186797 9.549459e-01 0.020 0 0
Degradation of CDH1 R-HSA-9766229 9.550025e-01 0.020 0 0
Interferon Signaling R-HSA-913531 9.564933e-01 0.019 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.565110e-01 0.019 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.565612e-01 0.019 0 0
Protein ubiquitination R-HSA-8852135 9.565612e-01 0.019 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.565612e-01 0.019 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.576659e-01 0.019 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.576659e-01 0.019 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.576659e-01 0.019 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.576659e-01 0.019 0 0
Cellular hexose transport R-HSA-189200 9.576659e-01 0.019 0 0
Degradation of DVL R-HSA-4641258 9.585569e-01 0.018 0 0
Telomere Maintenance R-HSA-157579 9.591904e-01 0.018 0 0
Signaling by NOTCH1 R-HSA-1980143 9.595483e-01 0.018 0 0
Neutrophil degranulation R-HSA-6798695 9.614219e-01 0.017 0 0
Toll-like Receptor Cascades R-HSA-168898 9.618260e-01 0.017 0 0
The phototransduction cascade R-HSA-2514856 9.619403e-01 0.017 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.621906e-01 0.017 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.621906e-01 0.017 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.621906e-01 0.017 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.621906e-01 0.017 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.621906e-01 0.017 0 0
Biosynthesis of maresins R-HSA-9018682 9.621906e-01 0.017 0 0
Formation of the ureteric bud R-HSA-9830674 9.621906e-01 0.017 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.621906e-01 0.017 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.621906e-01 0.017 0 0
Syndecan interactions R-HSA-3000170 9.621906e-01 0.017 0 0
Interleukin-20 family signaling R-HSA-8854691 9.621906e-01 0.017 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.622881e-01 0.017 0 0
Orc1 removal from chromatin R-HSA-68949 9.650193e-01 0.015 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.650193e-01 0.015 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.650193e-01 0.015 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.656956e-01 0.015 0 0
CYP2E1 reactions R-HSA-211999 9.662320e-01 0.015 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.662320e-01 0.015 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.662320e-01 0.015 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.662320e-01 0.015 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.662320e-01 0.015 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.662320e-01 0.015 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.662320e-01 0.015 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.662320e-01 0.015 0 0
Interleukin-6 family signaling R-HSA-6783589 9.662320e-01 0.015 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.668898e-01 0.015 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.670163e-01 0.015 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.671155e-01 0.015 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.678623e-01 0.014 0 0
Interleukin-1 signaling R-HSA-9020702 9.684787e-01 0.014 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.688057e-01 0.014 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.688057e-01 0.014 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.688057e-01 0.014 0 0
Attenuation phase R-HSA-3371568 9.688057e-01 0.014 0 0
Interleukin-1 family signaling R-HSA-446652 9.688462e-01 0.014 0 0
Nicotinate metabolism R-HSA-196807 9.693760e-01 0.014 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.698416e-01 0.013 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.698416e-01 0.013 0 0
Hyaluronan degradation R-HSA-2160916 9.698416e-01 0.013 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.698416e-01 0.013 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.698416e-01 0.013 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.698416e-01 0.013 0 0
Circadian clock R-HSA-9909396 9.700639e-01 0.013 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.716431e-01 0.012 0 0
Amyloid fiber formation R-HSA-977225 9.718471e-01 0.012 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.730655e-01 0.012 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.738470e-01 0.012 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.742306e-01 0.011 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.742306e-01 0.011 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.742306e-01 0.011 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.742306e-01 0.011 0 0
SLC transporter disorders R-HSA-5619102 9.745765e-01 0.011 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.758272e-01 0.011 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.758272e-01 0.011 0 0
Packaging Of Telomere Ends R-HSA-171306 9.759450e-01 0.011 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.759450e-01 0.011 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.759450e-01 0.011 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.759450e-01 0.011 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.759450e-01 0.011 0 0
Insulin processing R-HSA-264876 9.759450e-01 0.011 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.759450e-01 0.011 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.759450e-01 0.011 0 0
Regulation of CDH1 Function R-HSA-9764561 9.771927e-01 0.010 0 0
Developmental Biology R-HSA-1266738 9.773593e-01 0.010 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.774563e-01 0.010 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.785168e-01 0.009 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.785168e-01 0.009 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.785168e-01 0.009 0 0
Inflammasomes R-HSA-622312 9.785168e-01 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.785168e-01 0.009 0 0
Pyrimidine salvage R-HSA-73614 9.785168e-01 0.009 0 0
Platelet degranulation R-HSA-114608 9.787018e-01 0.009 0 0
Defective pyroptosis R-HSA-9710421 9.787382e-01 0.009 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.787382e-01 0.009 0 0
Signaling by SCF-KIT R-HSA-1433557 9.787382e-01 0.009 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.790859e-01 0.009 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.794496e-01 0.009 0 0
Ribosome-associated quality control R-HSA-9948299 9.802207e-01 0.009 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.805961e-01 0.009 0 0
Gap junction trafficking R-HSA-190828 9.806954e-01 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 9.808138e-01 0.008 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.808138e-01 0.008 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.808286e-01 0.008 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.808286e-01 0.008 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.808613e-01 0.008 0 0
Leishmania infection R-HSA-9658195 9.814466e-01 0.008 0 0
Parasitic Infection Pathways R-HSA-9824443 9.814466e-01 0.008 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.824321e-01 0.008 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.824321e-01 0.008 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.824321e-01 0.008 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.824321e-01 0.008 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.824321e-01 0.008 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.824321e-01 0.008 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.824783e-01 0.008 0 0
Parasite infection R-HSA-9664407 9.824783e-01 0.008 0 0
Leishmania phagocytosis R-HSA-9664417 9.824783e-01 0.008 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.828653e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.828653e-01 0.008 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.835160e-01 0.007 0 0
Selenoamino acid metabolism R-HSA-2408522 9.840889e-01 0.007 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.840990e-01 0.007 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.840990e-01 0.007 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.846975e-01 0.007 0 0
Cargo concentration in the ER R-HSA-5694530 9.846975e-01 0.007 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.846975e-01 0.007 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.846975e-01 0.007 0 0
UCH proteinases R-HSA-5689603 9.850888e-01 0.007 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.852625e-01 0.006 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.852625e-01 0.006 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.855744e-01 0.006 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.863339e-01 0.006 0 0
DAG1 glycosylations R-HSA-8931838 9.863339e-01 0.006 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.863339e-01 0.006 0 0
MHC class II antigen presentation R-HSA-2132295 9.865021e-01 0.006 0 0
Ion channel transport R-HSA-983712 9.865530e-01 0.006 0 0
Downstream TCR signaling R-HSA-202424 9.867447e-01 0.006 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.877297e-01 0.005 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.877954e-01 0.005 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.877954e-01 0.005 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.877954e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.877954e-01 0.005 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.881360e-01 0.005 0 0
Gap junction trafficking and regulation R-HSA-157858 9.881360e-01 0.005 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.881360e-01 0.005 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.881360e-01 0.005 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.883426e-01 0.005 0 0
SARS-CoV Infections R-HSA-9679506 9.892001e-01 0.005 0 0
tRNA processing R-HSA-72306 9.894462e-01 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.894957e-01 0.005 0 0
Cellular responses to stimuli R-HSA-8953897 9.900468e-01 0.004 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.900579e-01 0.004 0 0
RSV-host interactions R-HSA-9833110 9.900638e-01 0.004 0 0
Cellular responses to stress R-HSA-2262752 9.901033e-01 0.004 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.901106e-01 0.004 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.902521e-01 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 9.902665e-01 0.004 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.902665e-01 0.004 0 0
Gap junction assembly R-HSA-190861 9.902665e-01 0.004 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.902665e-01 0.004 0 0
Phospholipid metabolism R-HSA-1483257 9.903165e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.905522e-01 0.004 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.906365e-01 0.004 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.911671e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.913076e-01 0.004 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.913076e-01 0.004 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.913636e-01 0.004 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.917010e-01 0.004 0 0
HSF1 activation R-HSA-3371511 9.922374e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.922374e-01 0.003 0 0
G1/S-Specific Transcription R-HSA-69205 9.922374e-01 0.003 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.923138e-01 0.003 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.927521e-01 0.003 0 0
COPII-mediated vesicle transport R-HSA-204005 9.927893e-01 0.003 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.929152e-01 0.003 0 0
Potassium Channels R-HSA-1296071 9.929152e-01 0.003 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.930678e-01 0.003 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.930678e-01 0.003 0 0
Cleavage of the damaged purine R-HSA-110331 9.930678e-01 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.930678e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.930678e-01 0.003 0 0
Lysine catabolism R-HSA-71064 9.930678e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.930678e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.934139e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.934139e-01 0.003 0 0
Depurination R-HSA-73927 9.938095e-01 0.003 0 0
Elastic fibre formation R-HSA-1566948 9.938095e-01 0.003 0 0
Purine salvage R-HSA-74217 9.938095e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.938095e-01 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.940576e-01 0.003 0 0
HCMV Late Events R-HSA-9610379 9.944066e-01 0.002 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.944718e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.944718e-01 0.002 0 0
RAS processing R-HSA-9648002 9.944718e-01 0.002 0 0
Signaling by NOTCH4 R-HSA-9013694 9.949891e-01 0.002 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.950633e-01 0.002 0 0
Aggrephagy R-HSA-9646399 9.950633e-01 0.002 0 0
Diseases of Immune System R-HSA-5260271 9.950633e-01 0.002 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.950633e-01 0.002 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.950633e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.950633e-01 0.002 0 0
Glycogen metabolism R-HSA-8982491 9.950633e-01 0.002 0 0
Interleukin-2 family signaling R-HSA-451927 9.950633e-01 0.002 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.952767e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.954277e-01 0.002 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.954277e-01 0.002 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.955915e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.955915e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.955950e-01 0.002 0 0
Adaptive Immune System R-HSA-1280218 9.955995e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.960148e-01 0.002 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.960632e-01 0.002 0 0
HIV Transcription Initiation R-HSA-167161 9.960632e-01 0.002 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.960632e-01 0.002 0 0
Cellular response to chemical stress R-HSA-9711123 9.961256e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.963065e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.963952e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.963952e-01 0.002 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.964845e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.964845e-01 0.002 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.964845e-01 0.002 0 0
Depyrimidination R-HSA-73928 9.964845e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.965313e-01 0.002 0 0
Mitochondrial protein import R-HSA-1268020 9.967399e-01 0.001 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.967399e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.968399e-01 0.001 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.968608e-01 0.001 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.968608e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.968608e-01 0.001 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.969999e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.969999e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.970521e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.970899e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.971967e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.971967e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.972500e-01 0.001 0 0
Synthesis of DNA R-HSA-69239 9.973236e-01 0.001 0 0
Ion transport by P-type ATPases R-HSA-936837 9.973349e-01 0.001 0 0
Adipogenesis R-HSA-9843745 9.973674e-01 0.001 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.974968e-01 0.001 0 0
Somitogenesis R-HSA-9824272 9.974968e-01 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.974968e-01 0.001 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.977647e-01 0.001 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.978116e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.978207e-01 0.001 0 0
HCMV Early Events R-HSA-9609690 9.979335e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.980040e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.980324e-01 0.001 0 0
Neddylation R-HSA-8951664 9.981022e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.981855e-01 0.001 0 0
Intraflagellar transport R-HSA-5620924 9.982177e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.982177e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.982222e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.982347e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.982350e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.982350e-01 0.001 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.983768e-01 0.001 0 0
Co-inhibition by PD-1 R-HSA-389948 9.984134e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.985743e-01 0.001 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.986378e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.986899e-01 0.001 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.987310e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.987310e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.987310e-01 0.001 0 0
Signaling by NOTCH R-HSA-157118 9.987601e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.988422e-01 0.001 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.988622e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.989747e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.989882e-01 0.000 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.990966e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.991763e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.991933e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.992051e-01 0.000 0 0
Protein folding R-HSA-391251 9.992296e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.992797e-01 0.000 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.993068e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.993569e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.993569e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.993603e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.993603e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.993637e-01 0.000 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.993939e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.994873e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.994873e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.995231e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.995422e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.995422e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.995422e-01 0.000 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.995913e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.995913e-01 0.000 0 0
DNA Replication R-HSA-69306 9.995989e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.996067e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.996430e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.996759e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997091e-01 0.000 0 0
HCMV Infection R-HSA-9609646 9.997168e-01 0.000 0 0
Cellular response to hypoxia R-HSA-1234174 9.997402e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.997476e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997771e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997929e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.998091e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.998151e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.998152e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998526e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998779e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998893e-01 0.000 0 0
Hemostasis R-HSA-109582 9.998904e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998951e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999064e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999164e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999273e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999405e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999405e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999545e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999577e-01 0.000 0 0
Translation R-HSA-72766 9.999606e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999699e-01 0.000 0 0
Protein localization R-HSA-9609507 9.999720e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999720e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999746e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999766e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.999817e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999846e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999846e-01 0.000 0 0
Base Excision Repair R-HSA-73884 9.999864e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999909e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999914e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999939e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999945e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999975e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999980e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999985e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999986e-01 0.000 0 0
Immune System R-HSA-168256 9.999988e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999990e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999991e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999992e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999995e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999996e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999996e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999998e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999998e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999998e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999999e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999999e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 2.997602e-15 14.523 0 0
Attenuation phase R-HSA-3371568 2.342349e-12 11.630 0 0
Cell Cycle, Mitotic R-HSA-69278 3.117839e-12 11.506 0 0
M Phase R-HSA-68886 1.026523e-11 10.989 0 0
HSF1-dependent transactivation R-HSA-3371571 1.471934e-11 10.832 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.829548e-11 10.417 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.457690e-11 10.190 0 0
Cell Cycle Checkpoints R-HSA-69620 7.210466e-11 10.142 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.297396e-11 10.081 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.828209e-10 9.548 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.575410e-10 9.589 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.575410e-10 9.589 0 0
HSF1 activation R-HSA-3371511 3.717611e-10 9.430 0 0
Metabolism of RNA R-HSA-8953854 3.762849e-10 9.424 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.432459e-10 9.353 0 0
Axon guidance R-HSA-422475 8.709505e-10 9.060 0 0
Cell-Cell communication R-HSA-1500931 1.117484e-09 8.952 0 0
Apoptotic execution phase R-HSA-75153 1.193723e-09 8.923 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.737399e-09 8.760 0 0
Interleukin-12 signaling R-HSA-9020591 2.789436e-09 8.554 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.821633e-09 8.317 0 0
Nervous system development R-HSA-9675108 6.732802e-09 8.172 0 0
Influenza Infection R-HSA-168255 6.631947e-09 8.178 0 0
Meiotic synapsis R-HSA-1221632 1.276196e-08 7.894 0 0
G2/M Checkpoints R-HSA-69481 2.766913e-08 7.558 0 0
Cell junction organization R-HSA-446728 3.282033e-08 7.484 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.813216e-08 7.419 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.400066e-08 7.357 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.400066e-08 7.357 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.607450e-08 7.337 0 0
DNA Double Strand Break Response R-HSA-5693606 4.665958e-08 7.331 0 0
Cellular Senescence R-HSA-2559583 5.018602e-08 7.299 0 0
Interleukin-12 family signaling R-HSA-447115 5.448943e-08 7.264 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.540914e-08 7.184 0 0
Translation initiation complex formation R-HSA-72649 6.973054e-08 7.157 0 0
Peptide chain elongation R-HSA-156902 6.817313e-08 7.166 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.044401e-08 7.152 0 0
Signaling by ROBO receptors R-HSA-376176 9.216628e-08 7.035 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.231631e-07 6.910 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.202455e-07 6.920 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.199555e-07 6.921 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.477661e-07 6.830 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.617505e-07 6.791 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.641995e-07 6.785 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.709271e-07 6.767 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.125142e-07 6.673 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.125142e-07 6.673 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.412942e-07 6.617 0 0
Mitotic Anaphase R-HSA-68882 2.500255e-07 6.602 0 0
Homology Directed Repair R-HSA-5693538 2.844895e-07 6.546 0 0
Meiosis R-HSA-1500620 2.912215e-07 6.536 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.728742e-07 6.564 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.836555e-07 6.547 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.918394e-07 6.535 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.360932e-07 6.474 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.587186e-07 6.445 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.468695e-07 6.460 0 0
Separation of Sister Chromatids R-HSA-2467813 3.834969e-07 6.416 0 0
Mitotic Prophase R-HSA-68875 4.023292e-07 6.395 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.385590e-07 6.358 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.684081e-07 6.329 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.638288e-07 6.334 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.770158e-07 6.321 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.617470e-07 6.250 0 0
Ribosome-associated quality control R-HSA-9948299 6.672982e-07 6.176 0 0
Mitotic Prometaphase R-HSA-68877 7.235530e-07 6.141 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.265110e-07 6.083 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.190920e-07 6.037 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.076220e-06 5.968 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.215803e-06 5.915 0 0
Nucleosome assembly R-HSA-774815 1.215803e-06 5.915 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.212272e-06 5.916 0 0
Eukaryotic Translation Termination R-HSA-72764 1.299626e-06 5.886 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.693757e-06 5.771 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.198986e-06 5.658 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.198986e-06 5.658 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.239287e-06 5.650 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.377871e-06 5.624 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.735742e-06 5.563 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.741746e-06 5.562 0 0
Packaging Of Telomere Ends R-HSA-171306 2.891621e-06 5.539 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.118166e-06 5.506 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.324154e-06 5.478 0 0
Adherens junctions interactions R-HSA-418990 3.380179e-06 5.471 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.086488e-06 5.389 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.891858e-06 5.410 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.891858e-06 5.410 0 0
HDACs deacetylate histones R-HSA-3214815 4.456956e-06 5.351 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.562314e-06 5.341 0 0
Interferon Signaling R-HSA-913531 4.919285e-06 5.308 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.952663e-06 5.305 0 0
Viral mRNA Translation R-HSA-192823 5.311482e-06 5.275 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.678463e-06 5.246 0 0
DNA methylation R-HSA-5334118 5.787345e-06 5.238 0 0
Cell-cell junction organization R-HSA-421270 6.204819e-06 5.207 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.257029e-06 5.204 0 0
HATs acetylate histones R-HSA-3214847 7.306089e-06 5.136 0 0
Apoptosis R-HSA-109581 8.950796e-06 5.048 0 0
Chromatin modifying enzymes R-HSA-3247509 9.086947e-06 5.042 0 0
Selenocysteine synthesis R-HSA-2408557 1.015422e-05 4.993 0 0
Chromatin organization R-HSA-4839726 1.019379e-05 4.992 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.167882e-05 4.933 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.307068e-05 4.884 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.497632e-05 4.825 0 0
rRNA processing R-HSA-72312 1.499844e-05 4.824 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.634338e-05 4.787 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.650085e-05 4.782 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.650085e-05 4.782 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.012455e-05 4.696 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.079244e-05 4.682 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.084911e-05 4.681 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.207456e-05 4.656 0 0
Regulation of CDH1 Function R-HSA-9764561 2.288658e-05 4.640 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.445576e-05 4.612 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.476026e-05 4.606 0 0
PKR-mediated signaling R-HSA-9833482 2.548314e-05 4.594 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.732909e-05 4.563 0 0
Depyrimidination R-HSA-73928 2.732909e-05 4.563 0 0
Gene Silencing by RNA R-HSA-211000 2.995891e-05 4.523 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.530132e-05 4.452 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.566541e-05 4.448 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.566541e-05 4.448 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.778767e-05 4.423 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.808749e-05 4.419 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.053926e-05 4.392 0 0
Reproduction R-HSA-1474165 3.795190e-05 4.421 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.239293e-05 4.373 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.578485e-05 4.339 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.578485e-05 4.339 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.578485e-05 4.339 0 0
Chromosome Maintenance R-HSA-73886 4.833329e-05 4.316 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.363330e-05 4.196 0 0
Meiotic recombination R-HSA-912446 6.370057e-05 4.196 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.781989e-05 4.169 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.043502e-05 4.152 0 0
G2/M Transition R-HSA-69275 7.117254e-05 4.148 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.319345e-05 4.136 0 0
Signaling by ALK in cancer R-HSA-9700206 7.319345e-05 4.136 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.613784e-05 4.118 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.680721e-05 4.115 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.680721e-05 4.115 0 0
Cleavage of the damaged purine R-HSA-110331 7.680721e-05 4.115 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.724489e-05 4.112 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.724946e-05 4.059 0 0
HCMV Early Events R-HSA-9609690 9.666825e-05 4.015 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.627509e-05 4.016 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.795747e-05 4.009 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.637475e-05 4.016 0 0
Depurination R-HSA-73927 9.795747e-05 4.009 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.002769e-04 3.999 0 0
HIV Life Cycle R-HSA-162587 1.117539e-04 3.952 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.119938e-04 3.951 0 0
Defective pyroptosis R-HSA-9710421 1.160434e-04 3.935 0 0
Nuclear import of Rev protein R-HSA-180746 1.290495e-04 3.889 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.295254e-04 3.888 0 0
Glycolysis R-HSA-70171 1.390758e-04 3.857 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.685283e-04 3.773 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.685283e-04 3.773 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.647097e-04 3.783 0 0
Signaling by EGFR R-HSA-177929 1.715827e-04 3.766 0 0
Aggrephagy R-HSA-9646399 1.559061e-04 3.807 0 0
Host Interactions of HIV factors R-HSA-162909 1.612719e-04 3.792 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.787648e-04 3.748 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.787648e-04 3.748 0 0
tRNA processing in the nucleus R-HSA-6784531 1.791674e-04 3.747 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.791674e-04 3.747 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.824606e-04 3.739 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.995917e-04 3.700 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.037826e-04 3.691 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.184121e-04 3.661 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.184121e-04 3.661 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.184121e-04 3.661 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.184121e-04 3.661 0 0
Signaling by RAS mutants R-HSA-6802949 2.184121e-04 3.661 0 0
Viral Infection Pathways R-HSA-9824446 2.261574e-04 3.646 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.621430e-04 3.581 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.415328e-04 3.617 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.357651e-04 3.628 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.524466e-04 3.598 0 0
Cellular response to starvation R-HSA-9711097 2.561166e-04 3.592 0 0
Recycling pathway of L1 R-HSA-437239 2.666754e-04 3.574 0 0
Selective autophagy R-HSA-9663891 2.765013e-04 3.558 0 0
Diseases of programmed cell death R-HSA-9645723 2.765013e-04 3.558 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.767637e-04 3.558 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.774808e-04 3.557 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.841615e-04 3.546 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.410042e-04 3.467 0 0
RNA Polymerase I Transcription R-HSA-73864 3.421298e-04 3.466 0 0
Striated Muscle Contraction R-HSA-390522 3.514700e-04 3.454 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.514700e-04 3.454 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.054047e-04 3.392 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.075818e-04 3.390 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.174593e-04 3.379 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.225233e-04 3.374 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.300989e-04 3.366 0 0
Programmed Cell Death R-HSA-5357801 4.640978e-04 3.333 0 0
HIV Infection R-HSA-162906 4.665713e-04 3.331 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.750678e-04 3.323 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.750678e-04 3.323 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.843752e-04 3.315 0 0
Telomere Maintenance R-HSA-157579 5.121057e-04 3.291 0 0
Protein ubiquitination R-HSA-8852135 5.492484e-04 3.260 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.776668e-04 3.238 0 0
Protein folding R-HSA-391251 5.453872e-04 3.263 0 0
Translation R-HSA-72766 5.962692e-04 3.225 0 0
Signal Transduction R-HSA-162582 6.059195e-04 3.218 1 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.079184e-04 3.216 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.500844e-04 3.187 0 0
L1CAM interactions R-HSA-373760 6.550161e-04 3.184 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.568154e-04 3.183 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.699996e-04 3.174 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.815922e-04 3.166 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.862838e-04 3.163 0 0
MAP2K and MAPK activation R-HSA-5674135 7.427584e-04 3.129 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.767189e-04 3.110 0 0
Metabolism of non-coding RNA R-HSA-194441 7.965739e-04 3.099 0 0
snRNP Assembly R-HSA-191859 7.965739e-04 3.099 0 0
Muscle contraction R-HSA-397014 8.270783e-04 3.082 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.378311e-04 3.077 0 0
HCMV Infection R-HSA-9609646 8.714128e-04 3.060 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.797392e-04 3.056 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.897918e-04 3.051 0 0
p75NTR signals via NF-kB R-HSA-193639 9.453236e-04 3.024 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.005331e-03 2.998 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.013650e-03 2.994 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.085291e-03 2.964 0 0
NF-kB is activated and signals survival R-HSA-209560 1.085291e-03 2.964 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.102560e-03 2.958 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.115452e-03 2.953 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.115452e-03 2.953 0 0
Ub-specific processing proteases R-HSA-5689880 1.148560e-03 2.940 0 0
Amyloid fiber formation R-HSA-977225 1.257512e-03 2.900 0 0
Signaling by NOTCH R-HSA-157118 1.262911e-03 2.899 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.562163e-03 2.806 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.562163e-03 2.806 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.537431e-03 2.813 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.374497e-03 2.862 0 0
Glucose metabolism R-HSA-70326 1.522656e-03 2.817 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.620230e-03 2.790 0 0
Signaling by WNT R-HSA-195721 1.684384e-03 2.774 0 0
Co-inhibition by PD-1 R-HSA-389948 1.711527e-03 2.767 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.725263e-03 2.763 0 0
ESR-mediated signaling R-HSA-8939211 1.752124e-03 2.756 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.762810e-03 2.754 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.795042e-03 2.746 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.838537e-03 2.736 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.915319e-03 2.718 0 0
Base Excision Repair R-HSA-73884 1.918213e-03 2.717 0 0
EGFR downregulation R-HSA-182971 1.938486e-03 2.713 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.975083e-03 2.704 0 0
Smooth Muscle Contraction R-HSA-445355 2.108359e-03 2.676 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.188152e-03 2.660 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.296846e-03 2.639 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.340837e-03 2.631 0 0
Kinesins R-HSA-983189 2.355641e-03 2.628 0 0
mRNA Splicing R-HSA-72172 2.491520e-03 2.604 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 2.559672e-03 2.592 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.622999e-03 2.581 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.643843e-03 2.578 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.913706e-03 2.536 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.922483e-03 2.534 0 0
Signaling by Interleukins R-HSA-449147 2.928913e-03 2.533 0 0
Gap junction trafficking and regulation R-HSA-157858 2.940980e-03 2.532 0 0
Autophagy R-HSA-9612973 2.956810e-03 2.529 0 0
MAPK family signaling cascades R-HSA-5683057 2.963301e-03 2.528 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.991997e-03 2.524 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.665499e-03 2.436 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.281607e-03 2.484 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.307880e-03 2.480 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.590310e-03 2.445 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.554769e-03 2.449 0 0
Semaphorin interactions R-HSA-373755 3.554769e-03 2.449 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.517065e-03 2.454 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.057815e-03 2.515 0 0
Selenoamino acid metabolism R-HSA-2408522 3.108793e-03 2.507 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.714719e-03 2.430 0 0
DNA Repair R-HSA-73894 3.877460e-03 2.411 0 0
Regulation of signaling by CBL R-HSA-912631 3.934945e-03 2.405 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.004230e-03 2.397 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.007469e-03 2.397 0 0
Late endosomal microautophagy R-HSA-9615710 4.007469e-03 2.397 0 0
Regulation of PTEN localization R-HSA-8948747 4.118990e-03 2.385 0 0
DNA Replication R-HSA-69306 4.220751e-03 2.375 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.244633e-03 2.372 0 0
Platelet degranulation R-HSA-114608 4.345901e-03 2.362 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.405682e-03 2.356 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.435546e-03 2.353 0 0
Orc1 removal from chromatin R-HSA-68949 4.572720e-03 2.340 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.923653e-03 2.308 0 0
Nephrin family interactions R-HSA-373753 4.994491e-03 2.302 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.091423e-03 2.293 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.091423e-03 2.293 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.623415e-03 2.250 0 0
Deubiquitination R-HSA-5688426 5.652060e-03 2.248 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.738196e-03 2.241 0 0
HCMV Late Events R-HSA-9610379 5.764388e-03 2.239 0 0
FLT3 signaling in disease R-HSA-9682385 5.873830e-03 2.231 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.892834e-03 2.230 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.019767e-03 2.220 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.104181e-03 2.214 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.104181e-03 2.214 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.104181e-03 2.214 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.104181e-03 2.214 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.886930e-03 2.162 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.071456e-03 2.150 0 0
Membrane Trafficking R-HSA-199991 7.192446e-03 2.143 0 0
Regulation of TP53 Activity R-HSA-5633007 7.209911e-03 2.142 0 0
Degradation of CDH1 R-HSA-9766229 7.337532e-03 2.134 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.337532e-03 2.134 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.337532e-03 2.134 0 0
Assembly Of The HIV Virion R-HSA-175474 7.753842e-03 2.110 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.756499e-03 2.110 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.258359e-03 2.083 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.258359e-03 2.083 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.680626e-03 2.061 0 0
Gap junction trafficking R-HSA-190828 8.941752e-03 2.049 0 0
S Phase R-HSA-69242 9.091522e-03 2.041 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 9.101277e-03 2.041 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.208132e-03 2.036 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.413117e-03 2.026 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 9.996238e-03 2.000 0 0
Maturation of protein E R-HSA-9694493 9.996238e-03 2.000 0 0
Maturation of protein E R-HSA-9683683 9.996238e-03 2.000 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.192482e-02 1.924 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.178249e-02 1.929 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.178249e-02 1.929 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.138725e-02 1.944 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.178249e-02 1.929 0 0
Josephin domain DUBs R-HSA-5689877 1.192482e-02 1.924 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.178249e-02 1.929 0 0
Post NMDA receptor activation events R-HSA-438064 1.261164e-02 1.899 0 0
Pexophagy R-HSA-9664873 1.192482e-02 1.924 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.158708e-02 1.936 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.265206e-02 1.898 0 0
Hedgehog 'off' state R-HSA-5610787 1.319910e-02 1.879 0 0
Rap1 signalling R-HSA-392517 1.332864e-02 1.875 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.414400e-02 1.849 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.416464e-02 1.849 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.438974e-02 1.842 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.438974e-02 1.842 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.438974e-02 1.842 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.478647e-02 1.830 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.497645e-02 1.825 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.497645e-02 1.825 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.499616e-02 1.824 0 0
Macroautophagy R-HSA-1632852 1.532096e-02 1.815 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.533938e-02 1.814 0 0
PECAM1 interactions R-HSA-210990 1.590657e-02 1.798 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.590657e-02 1.798 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.604061e-02 1.795 0 0
Budding and maturation of HIV virion R-HSA-162588 1.610002e-02 1.793 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.610002e-02 1.793 0 0
Negative regulation of MET activity R-HSA-6807004 1.627537e-02 1.788 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.642807e-02 1.784 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.661185e-02 1.780 0 0
Interferon alpha/beta signaling R-HSA-909733 1.704415e-02 1.768 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.711255e-02 1.767 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.753853e-02 1.756 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.753853e-02 1.756 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.753853e-02 1.756 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.766047e-02 1.753 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.766047e-02 1.753 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.849637e-02 1.733 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.849637e-02 1.733 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.849637e-02 1.733 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.849637e-02 1.733 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.849637e-02 1.733 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.849637e-02 1.733 0 0
Signaling by FGFR4 R-HSA-5654743 1.867487e-02 1.729 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.872603e-02 1.728 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.872603e-02 1.728 0 0
Negative regulation of FLT3 R-HSA-9706369 1.872603e-02 1.728 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.913296e-02 1.718 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.926511e-02 1.715 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.937281e-02 1.713 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.965566e-02 1.707 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.965566e-02 1.707 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.998856e-02 1.699 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.998856e-02 1.699 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.488092e-02 1.604 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.081867e-02 1.682 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.081867e-02 1.682 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.068747e-02 1.684 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.631967e-02 1.580 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.286778e-02 1.641 0 0
Integrin signaling R-HSA-354192 2.168336e-02 1.664 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.494284e-02 1.603 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.494284e-02 1.603 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.390756e-02 1.621 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.347429e-02 1.629 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.134929e-02 1.671 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.662394e-02 1.575 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.488092e-02 1.604 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.488092e-02 1.604 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.617240e-02 1.582 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.306343e-02 1.637 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.306343e-02 1.637 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.161345e-02 1.665 0 0
Cellular response to chemical stress R-HSA-9711123 2.660191e-02 1.575 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.168336e-02 1.664 0 0
Signaling by FGFR3 R-HSA-5654741 2.384016e-02 1.623 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.293059e-02 1.640 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.384016e-02 1.623 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.384016e-02 1.623 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.349769e-02 1.629 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.083195e-02 1.681 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.675908e-02 1.573 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.675908e-02 1.573 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.675908e-02 1.573 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.675908e-02 1.573 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.631967e-02 1.580 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.631967e-02 1.580 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.252061e-02 1.647 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.675908e-02 1.573 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.382548e-02 1.623 0 0
SARS-CoV Infections R-HSA-9679506 2.534724e-02 1.596 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.780477e-02 1.556 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.782736e-02 1.556 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.804433e-02 1.552 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.804433e-02 1.552 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.816602e-02 1.550 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.816602e-02 1.550 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.816602e-02 1.550 0 0
Centrosome maturation R-HSA-380287 2.819457e-02 1.550 0 0
RAF activation R-HSA-5673000 2.853550e-02 1.545 0 0
Mitophagy R-HSA-5205647 2.853550e-02 1.545 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.853550e-02 1.545 0 0
Signaling by NOTCH2 R-HSA-1980145 2.853550e-02 1.545 0 0
ER-Phagosome pathway R-HSA-1236974 2.864288e-02 1.543 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.078834e-02 1.512 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.078834e-02 1.512 0 0
Signaling by NOTCH1 R-HSA-1980143 3.080193e-02 1.511 0 0
Cilium Assembly R-HSA-5617833 3.093731e-02 1.510 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.138481e-02 1.503 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.138481e-02 1.503 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.266799e-02 1.486 0 0
Developmental Biology R-HSA-1266738 3.267580e-02 1.486 0 0
Signaling by NOTCH3 R-HSA-9012852 3.315212e-02 1.479 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.326882e-02 1.478 0 0
GAB1 signalosome R-HSA-180292 3.367780e-02 1.473 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.410778e-02 1.467 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.474573e-02 1.459 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.537827e-02 1.451 0 0
Interleukin-37 signaling R-HSA-9008059 3.537827e-02 1.451 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.578023e-02 1.446 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.578023e-02 1.446 0 0
Signaling by FGFR1 R-HSA-5654736 3.661725e-02 1.436 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.661725e-02 1.436 0 0
RET signaling R-HSA-8853659 3.677826e-02 1.434 0 0
Gap junction degradation R-HSA-190873 3.687458e-02 1.433 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.687458e-02 1.433 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.687458e-02 1.433 0 0
Unwinding of DNA R-HSA-176974 3.687458e-02 1.433 0 0
G1/S Transition R-HSA-69206 3.693578e-02 1.433 0 0
Death Receptor Signaling R-HSA-73887 3.729774e-02 1.428 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.804004e-02 1.420 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.805446e-02 1.420 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.891703e-02 1.410 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.891703e-02 1.410 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.999552e-02 1.398 0 0
Translesion Synthesis by POLH R-HSA-110320 3.999552e-02 1.398 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.029532e-02 1.395 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.040917e-02 1.394 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.040917e-02 1.394 0 0
Degradation of DVL R-HSA-4641258 4.145442e-02 1.382 0 0
Signaling by FGFR2 R-HSA-5654738 4.301209e-02 1.366 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.492793e-02 1.347 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.084670e-02 1.294 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.084670e-02 1.294 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.696463e-02 1.328 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.696463e-02 1.328 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.843263e-02 1.233 0 0
DCC mediated attractive signaling R-HSA-418885 4.869070e-02 1.313 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.869070e-02 1.313 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.869070e-02 1.313 0 0
Translesion synthesis by POLI R-HSA-5656121 5.804122e-02 1.236 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.834648e-02 1.165 0 0
Translesion synthesis by POLK R-HSA-5655862 6.834648e-02 1.165 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.834648e-02 1.165 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.475493e-02 1.262 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.321803e-02 1.199 0 0
Dual Incision in GG-NER R-HSA-5696400 6.517876e-02 1.186 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.007277e-02 1.300 0 0
mRNA 3'-end processing R-HSA-72187 5.007277e-02 1.300 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.044449e-02 1.297 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.517876e-02 1.186 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.782982e-02 1.238 0 0
Prolonged ERK activation events R-HSA-169893 5.804122e-02 1.236 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.627774e-02 1.335 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.827133e-02 1.235 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.184549e-02 1.285 0 0
Translesion synthesis by REV1 R-HSA-110312 4.869070e-02 1.313 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.517876e-02 1.186 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.987834e-02 1.302 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.817266e-02 1.235 0 0
PTEN Regulation R-HSA-6807070 5.927318e-02 1.227 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.234215e-02 1.205 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.044449e-02 1.297 0 0
Antigen processing-Cross presentation R-HSA-1236975 4.669089e-02 1.331 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 6.409738e-02 1.193 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.970025e-02 1.224 0 0
G1 Phase R-HSA-69236 4.627774e-02 1.335 0 0
Cyclin D associated events in G1 R-HSA-69231 4.627774e-02 1.335 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.819536e-02 1.166 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.830449e-02 1.234 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.750162e-02 1.240 0 0
Stabilization of p53 R-HSA-69541 5.197138e-02 1.284 0 0
Glycogen synthesis R-HSA-3322077 4.701671e-02 1.328 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.593555e-02 1.252 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.409738e-02 1.193 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.834648e-02 1.165 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.386272e-02 1.195 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.386272e-02 1.195 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.386272e-02 1.195 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.589447e-02 1.338 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.473691e-02 1.189 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.782982e-02 1.238 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.980888e-02 1.223 0 0
Signaling by Hedgehog R-HSA-5358351 5.609527e-02 1.251 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.044449e-02 1.297 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.939821e-02 1.306 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.827133e-02 1.235 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.517876e-02 1.186 0 0
Interleukin-1 family signaling R-HSA-446652 5.232678e-02 1.281 0 0
Signaling by NOTCH4 R-HSA-9013694 4.874411e-02 1.312 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.475493e-02 1.262 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.007277e-02 1.300 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 5.475493e-02 1.262 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.531232e-02 1.257 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.321803e-02 1.199 0 0
Gap junction assembly R-HSA-190861 6.517876e-02 1.186 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.927318e-02 1.227 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.184549e-02 1.285 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.921501e-02 1.228 0 0
Hedgehog 'on' state R-HSA-5632684 6.997585e-02 1.155 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.077884e-02 1.150 0 0
Integration of provirus R-HSA-162592 7.125360e-02 1.147 0 0
TNF signaling R-HSA-75893 7.155913e-02 1.145 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.155913e-02 1.145 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.257222e-02 1.139 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.257222e-02 1.139 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.257222e-02 1.139 0 0
Regulation of Apoptosis R-HSA-169911 7.257222e-02 1.139 0 0
Gene expression (Transcription) R-HSA-74160 7.311789e-02 1.136 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.336158e-02 1.135 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.537875e-02 1.123 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.552056e-02 1.122 0 0
Signaling by MET R-HSA-6806834 7.639027e-02 1.117 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.684684e-02 1.114 0 0
Interleukin-1 signaling R-HSA-9020702 7.713211e-02 1.113 0 0
Signaling by Hippo R-HSA-2028269 7.959629e-02 1.099 1 1
Glycogen storage diseases R-HSA-3229121 7.959629e-02 1.099 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.045376e-02 1.094 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.145881e-02 1.089 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.538377e-02 1.069 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.538377e-02 1.069 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.538377e-02 1.069 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.538377e-02 1.069 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.539422e-02 1.069 0 0
Netrin mediated repulsion signals R-HSA-418886 8.577285e-02 1.067 0 0
TCR signaling R-HSA-202403 8.624883e-02 1.064 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.882306e-02 1.051 0 0
Degradation of AXIN R-HSA-4641257 8.882306e-02 1.051 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.953291e-02 1.048 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.155600e-02 1.038 0 0
Trafficking of AMPA receptors R-HSA-399719 9.155600e-02 1.038 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 9.177130e-02 1.037 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.177130e-02 1.037 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 9.177130e-02 1.037 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 9.177130e-02 1.037 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.210297e-02 1.036 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.279857e-02 1.032 0 0
Deadenylation of mRNA R-HSA-429947 9.295096e-02 1.032 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.295096e-02 1.032 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 9.295096e-02 1.032 0 0
Neurodegenerative Diseases R-HSA-8863678 9.295096e-02 1.032 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.316476e-02 1.031 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.332923e-02 1.030 0 0
Netrin-1 signaling R-HSA-373752 9.332923e-02 1.030 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.377340e-02 1.028 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.377340e-02 1.028 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.377340e-02 1.028 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.470523e-02 1.024 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 9.470523e-02 1.024 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 9.470523e-02 1.024 0 0
MET activates PTPN11 R-HSA-8865999 9.470523e-02 1.024 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.630702e-02 1.016 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.784179e-02 1.009 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.816422e-02 1.008 0 0
Signaling by ERBB2 R-HSA-1227986 9.817149e-02 1.008 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.912948e-02 1.004 0 0
Frs2-mediated activation R-HSA-170968 1.007633e-01 0.997 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.016803e-01 0.993 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.016803e-01 0.993 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.016803e-01 0.993 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.016969e-01 0.993 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.041945e-01 0.982 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.041945e-01 0.982 0 0
Signaling by FGFR R-HSA-190236 1.042373e-01 0.982 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.042810e-01 0.982 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.042810e-01 0.982 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.042810e-01 0.982 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.048438e-01 0.979 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.048438e-01 0.979 0 0
IRE1alpha activates chaperones R-HSA-381070 1.052284e-01 0.978 0 0
MAP kinase activation R-HSA-450294 1.056351e-01 0.976 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.056351e-01 0.976 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.061708e-01 0.974 0 0
Type I hemidesmosome assembly R-HSA-446107 1.061708e-01 0.974 0 0
Formation of annular gap junctions R-HSA-196025 1.061708e-01 0.974 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.062855e-01 0.974 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.104438e-01 0.957 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.104438e-01 0.957 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.120451e-01 0.951 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.120451e-01 0.951 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.125970e-01 0.948 0 0
G alpha (12/13) signalling events R-HSA-416482 1.133313e-01 0.946 0 0
Metalloprotease DUBs R-HSA-5689901 1.162938e-01 0.934 0 0
Glycogen metabolism R-HSA-8982491 1.168192e-01 0.932 0 0
Regulation of KIT signaling R-HSA-1433559 1.173188e-01 0.931 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.187785e-01 0.925 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.187785e-01 0.925 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.187785e-01 0.925 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.187785e-01 0.925 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.187785e-01 0.925 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.187785e-01 0.925 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 1.187785e-01 0.925 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.194772e-01 0.923 0 0
Sensory processing of sound R-HSA-9659379 1.205796e-01 0.919 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.210498e-01 0.917 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.210498e-01 0.917 0 0
Signaling by PTK6 R-HSA-8848021 1.215245e-01 0.915 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.215245e-01 0.915 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.228607e-01 0.911 0 0
Pyruvate metabolism R-HSA-70268 1.265963e-01 0.898 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.270899e-01 0.896 0 0
FLT3 Signaling R-HSA-9607240 1.270899e-01 0.896 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.270899e-01 0.896 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.277641e-01 0.894 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.277641e-01 0.894 0 0
Regulation of gap junction activity R-HSA-191650 1.277641e-01 0.894 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.277641e-01 0.894 0 0
MTF1 activates gene expression R-HSA-5660489 1.277641e-01 0.894 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.282480e-01 0.892 0 0
ARMS-mediated activation R-HSA-170984 1.282480e-01 0.892 0 0
Lipophagy R-HSA-9613354 1.282480e-01 0.892 0 0
Calcineurin activates NFAT R-HSA-2025928 1.282480e-01 0.892 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 1.282480e-01 0.892 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.282480e-01 0.892 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.282480e-01 0.892 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.282480e-01 0.892 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.289662e-01 0.890 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.289662e-01 0.890 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.289662e-01 0.890 0 0
Ion transport by P-type ATPases R-HSA-936837 1.299435e-01 0.886 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.300084e-01 0.886 0 0
NRAGE signals death through JNK R-HSA-193648 1.300084e-01 0.886 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.335335e-01 0.874 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.335335e-01 0.874 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.346881e-01 0.871 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.347377e-01 0.871 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.349664e-01 0.870 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.349664e-01 0.870 0 0
Protein methylation R-HSA-8876725 1.349664e-01 0.870 0 0
Circadian clock R-HSA-9909396 1.374619e-01 0.862 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.861158e-01 0.730 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.861158e-01 0.730 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.861158e-01 0.730 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.861158e-01 0.730 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.861158e-01 0.730 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.657571e-01 0.576 0 0
Mitochondrial transcription initiation R-HSA-163282 2.657571e-01 0.576 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.657571e-01 0.576 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.657571e-01 0.576 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.657571e-01 0.576 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.657571e-01 0.576 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.657571e-01 0.576 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.657571e-01 0.576 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.657571e-01 0.576 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.657571e-01 0.576 0 0
IRS activation R-HSA-74713 1.630225e-01 0.788 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.630225e-01 0.788 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.630225e-01 0.788 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.997344e-01 0.700 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.517828e-01 0.819 0 0
2-LTR circle formation R-HSA-164843 1.517828e-01 0.819 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.372783e-01 0.625 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.372783e-01 0.625 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.372783e-01 0.625 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.372783e-01 0.625 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.372783e-01 0.625 0 0
Signaling by APC mutants R-HSA-4839744 1.765512e-01 0.753 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.765512e-01 0.753 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.765512e-01 0.753 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.765512e-01 0.753 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.023324e-01 0.694 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.023324e-01 0.694 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.751402e-01 0.560 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.751402e-01 0.560 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.751402e-01 0.560 0 0
Recycling of eIF2:GDP R-HSA-72731 2.751402e-01 0.560 0 0
SOS-mediated signalling R-HSA-112412 2.751402e-01 0.560 0 0
Disorders of Developmental Biology R-HSA-9675151 1.731617e-01 0.762 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.731617e-01 0.762 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.289131e-01 0.640 0 0
Disorders of Nervous System Development R-HSA-9697154 2.289131e-01 0.640 0 0
Pervasive developmental disorders R-HSA-9005895 2.289131e-01 0.640 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.289131e-01 0.640 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.289131e-01 0.640 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.289131e-01 0.640 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.289131e-01 0.640 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.289131e-01 0.640 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.289131e-01 0.640 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.289131e-01 0.640 0 0
Ephrin signaling R-HSA-3928664 2.145492e-01 0.668 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.561784e-01 0.806 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.177950e-01 0.662 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.582931e-01 0.588 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.582931e-01 0.588 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.363328e-01 0.626 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.552858e-01 0.593 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.712753e-01 0.766 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.976726e-01 0.704 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.976726e-01 0.704 0 0
Telomere Extension By Telomerase R-HSA-171319 2.745901e-01 0.561 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.502043e-01 0.602 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.107650e-01 0.676 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.188376e-01 0.660 0 0
Dual incision in TC-NER R-HSA-6782135 2.443502e-01 0.612 0 0
Neutrophil degranulation R-HSA-6798695 2.193864e-01 0.659 0 0
G0 and Early G1 R-HSA-1538133 2.011611e-01 0.696 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.606507e-01 0.794 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.291840e-01 0.640 0 0
EPH-Ephrin signaling R-HSA-2682334 1.741667e-01 0.759 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.826898e-01 0.738 0 0
DNA Damage Bypass R-HSA-73893 2.378990e-01 0.624 0 0
UCH proteinases R-HSA-5689603 1.637596e-01 0.786 0 0
Activation of the pre-replicative complex R-HSA-68962 1.706538e-01 0.768 0 0
Repression of WNT target genes R-HSA-4641265 2.289131e-01 0.640 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.630225e-01 0.788 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.630225e-01 0.788 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.751402e-01 0.560 0 0
DNA strand elongation R-HSA-69190 2.011611e-01 0.696 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.361788e-01 0.627 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.502043e-01 0.602 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.459605e-01 0.836 0 0
Regulation of IFNG signaling R-HSA-877312 2.289131e-01 0.640 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.944326e-01 0.711 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.363328e-01 0.626 0 0
Synthesis of DNA R-HSA-69239 1.736471e-01 0.760 0 0
Interleukin-6 signaling R-HSA-1059683 2.560902e-01 0.592 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.001081e-01 0.699 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.574749e-01 0.589 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.508005e-01 0.822 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.508005e-01 0.822 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.720952e-01 0.764 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.997344e-01 0.700 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.361788e-01 0.627 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.378125e-01 0.861 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.849267e-01 0.733 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.107650e-01 0.676 0 0
Intraflagellar transport R-HSA-5620924 2.241815e-01 0.649 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.604566e-01 0.584 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.720952e-01 0.764 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.442325e-01 0.612 0 0
Signalling to ERKs R-HSA-187687 1.468688e-01 0.833 0 0
Heme signaling R-HSA-9707616 1.907184e-01 0.720 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.997366e-01 0.700 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.560902e-01 0.592 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.861417e-01 0.730 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.672559e-01 0.573 0 0
Toll-like Receptor Cascades R-HSA-168898 1.459191e-01 0.836 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.971645e-01 0.705 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.971645e-01 0.705 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.672559e-01 0.573 0 0
The NLRP3 inflammasome R-HSA-844456 2.361788e-01 0.627 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.130695e-01 0.671 0 0
Downstream TCR signaling R-HSA-202424 1.493625e-01 0.826 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.171133e-01 0.663 0 0
Vesicle-mediated transport R-HSA-5653656 1.818321e-01 0.740 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.861158e-01 0.730 0 0
Inhibition of PKR R-HSA-169131 1.861158e-01 0.730 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.657571e-01 0.576 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.657571e-01 0.576 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.997344e-01 0.700 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.023324e-01 0.694 0 0
Signaling by AXIN mutants R-HSA-4839735 2.023324e-01 0.694 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.751402e-01 0.560 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.997366e-01 0.700 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.363328e-01 0.626 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.502043e-01 0.602 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.502043e-01 0.602 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.619202e-01 0.582 0 0
Interleukin-17 signaling R-HSA-448424 1.867295e-01 0.729 0 0
Signaling by TGFB family members R-HSA-9006936 1.626592e-01 0.789 0 0
RNA Polymerase II Transcription R-HSA-73857 2.372059e-01 0.625 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.289131e-01 0.640 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.490612e-01 0.827 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.171133e-01 0.663 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.907184e-01 0.720 0 0
Oncogene Induced Senescence R-HSA-2559585 1.468688e-01 0.833 0 0
PCP/CE pathway R-HSA-4086400 1.825914e-01 0.739 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.133551e-01 0.671 0 0
CHL1 interactions R-HSA-447041 2.751402e-01 0.560 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.751402e-01 0.560 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.751402e-01 0.560 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.517828e-01 0.819 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.502043e-01 0.602 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.089679e-01 0.680 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.798203e-01 0.745 0 0
Signal transduction by L1 R-HSA-445144 2.582931e-01 0.588 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.552858e-01 0.593 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.536135e-01 0.814 0 0
Other interleukin signaling R-HSA-449836 2.361788e-01 0.627 0 0
Gluconeogenesis R-HSA-70263 2.241815e-01 0.649 0 0
Ion homeostasis R-HSA-5578775 2.188376e-01 0.660 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.997344e-01 0.700 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.372783e-01 0.625 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.661397e-01 0.575 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.490612e-01 0.827 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.552858e-01 0.593 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.517828e-01 0.819 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.849267e-01 0.733 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.314647e-01 0.636 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.602042e-01 0.795 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.751402e-01 0.560 0 0
Cellular response to hypoxia R-HSA-1234174 2.250662e-01 0.648 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.552858e-01 0.593 0 0
ABC-family proteins mediated transport R-HSA-382556 2.593268e-01 0.586 0 0
Signaling by Leptin R-HSA-2586552 1.517828e-01 0.819 0 0
Specification of primordial germ cells R-HSA-9827857 1.935084e-01 0.713 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.997344e-01 0.700 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.731617e-01 0.762 0 0
Inositol phosphate metabolism R-HSA-1483249 2.154498e-01 0.667 0 0
tRNA processing R-HSA-72306 2.379669e-01 0.623 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.544708e-01 0.811 0 0
Regulation of BACH1 activity R-HSA-9708530 1.536135e-01 0.814 0 0
TBC/RABGAPs R-HSA-8854214 2.751911e-01 0.560 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.751911e-01 0.560 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.807899e-01 0.552 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.807899e-01 0.552 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.836731e-01 0.547 0 0
Signal regulatory protein family interactions R-HSA-391160 2.836731e-01 0.547 0 0
Zinc transporters R-HSA-435354 2.836731e-01 0.547 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.903944e-01 0.537 0 0
Proteasome assembly R-HSA-9907900 2.910359e-01 0.536 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.941821e-01 0.531 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.941821e-01 0.531 0 0
DARPP-32 events R-HSA-180024 2.941821e-01 0.531 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.941821e-01 0.531 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.944182e-01 0.531 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.952879e-01 0.530 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.998677e-01 0.523 0 0
Opioid Signalling R-HSA-111885 3.013259e-01 0.521 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.035704e-01 0.518 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.035704e-01 0.518 0 0
Erythropoietin activates RAS R-HSA-9027284 3.114851e-01 0.507 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.114851e-01 0.507 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.114851e-01 0.507 0 0
Formation of the anterior neural plate R-HSA-9823739 3.114851e-01 0.507 0 0
Adrenoceptors R-HSA-390696 3.128988e-01 0.505 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.128988e-01 0.505 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.139991e-01 0.503 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.172554e-01 0.499 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.199044e-01 0.495 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.217268e-01 0.493 0 0
Nucleotide Excision Repair R-HSA-5696398 3.230212e-01 0.491 0 0
Diseases of DNA repair R-HSA-9675135 3.232921e-01 0.490 0 0
FGFR2 alternative splicing R-HSA-6803529 3.265395e-01 0.486 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.265395e-01 0.486 0 0
Infectious disease R-HSA-5663205 3.353450e-01 0.475 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.376094e-01 0.472 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.376094e-01 0.472 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.376094e-01 0.472 0 0
Signalling to ERK5 R-HSA-198765 3.376094e-01 0.472 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.376094e-01 0.472 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.376094e-01 0.472 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.376094e-01 0.472 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.376094e-01 0.472 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.376094e-01 0.472 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.376094e-01 0.472 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.376094e-01 0.472 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.376094e-01 0.472 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.376094e-01 0.472 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.376094e-01 0.472 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.376094e-01 0.472 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.376094e-01 0.472 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.376094e-01 0.472 0 0
Transcription from mitochondrial promoters R-HSA-75944 3.376094e-01 0.472 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.376094e-01 0.472 0 0
C6 deamination of adenosine R-HSA-75102 3.376094e-01 0.472 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.376094e-01 0.472 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.376094e-01 0.472 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.376094e-01 0.472 0 0
DSCAM interactions R-HSA-376172 3.376094e-01 0.472 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.376094e-01 0.472 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.376094e-01 0.472 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.378057e-01 0.471 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.378057e-01 0.471 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.393644e-01 0.469 0 0
MHC class II antigen presentation R-HSA-2132295 3.407642e-01 0.468 0 0
Syndecan interactions R-HSA-3000170 3.496070e-01 0.456 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.502120e-01 0.456 0 0
ALK mutants bind TKIs R-HSA-9700645 3.502120e-01 0.456 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.502120e-01 0.456 0 0
Regulation of signaling by NODAL R-HSA-1433617 3.502120e-01 0.456 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.502120e-01 0.456 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.502120e-01 0.456 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.502120e-01 0.456 0 0
MAPK1 (ERK2) activation R-HSA-112411 3.502120e-01 0.456 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.528367e-01 0.452 0 0
Signaling by NTRKs R-HSA-166520 3.529721e-01 0.452 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.536510e-01 0.451 0 0
Adaptive Immune System R-HSA-1280218 3.550543e-01 0.450 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.558115e-01 0.449 0 0
Diseases of Immune System R-HSA-5260271 3.558115e-01 0.449 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.586995e-01 0.445 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.594454e-01 0.444 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.671640e-01 0.435 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.671640e-01 0.435 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.671640e-01 0.435 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.671640e-01 0.435 0 0
Signaling by VEGF R-HSA-194138 3.719273e-01 0.430 0 0
Potential therapeutics for SARS R-HSA-9679191 3.719799e-01 0.429 0 0
Immune System R-HSA-168256 3.722624e-01 0.429 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 3.726033e-01 0.429 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.738805e-01 0.427 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.741997e-01 0.427 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.741997e-01 0.427 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.741997e-01 0.427 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.741997e-01 0.427 0 0
Extension of Telomeres R-HSA-180786 3.861293e-01 0.413 0 0
Binding and entry of HIV virion R-HSA-173107 3.868056e-01 0.413 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.868056e-01 0.413 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.868056e-01 0.413 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.868056e-01 0.413 0 0
Regulation of CDH11 function R-HSA-9762292 3.868056e-01 0.413 0 0
PI3K/AKT activation R-HSA-198203 3.868056e-01 0.413 0 0
Formation of intermediate mesoderm R-HSA-9761174 3.868056e-01 0.413 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 3.868056e-01 0.413 0 0
Signal attenuation R-HSA-74749 3.868056e-01 0.413 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.868056e-01 0.413 0 0
Translation of Structural Proteins R-HSA-9683701 3.919726e-01 0.407 0 0
ABC transporter disorders R-HSA-5619084 3.934099e-01 0.405 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.947522e-01 0.404 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.947522e-01 0.404 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.947522e-01 0.404 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.947522e-01 0.404 0 0
Long-term potentiation R-HSA-9620244 3.957016e-01 0.403 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.957016e-01 0.403 0 0
Tight junction interactions R-HSA-420029 3.957016e-01 0.403 0 0
Formation of the nephric duct R-HSA-9830364 3.957016e-01 0.403 0 0
HDMs demethylate histones R-HSA-3214842 3.957016e-01 0.403 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.970290e-01 0.401 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.019012e-01 0.396 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.024342e-01 0.395 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.024342e-01 0.395 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.024342e-01 0.395 0 0
FasL/ CD95L signaling R-HSA-75157 4.024342e-01 0.395 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.024342e-01 0.395 0 0
Intracellular oxygen transport R-HSA-8981607 4.024342e-01 0.395 0 0
Histamine receptors R-HSA-390650 4.024342e-01 0.395 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.034936e-01 0.394 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.100492e-01 0.387 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.100492e-01 0.387 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.100492e-01 0.387 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 4.100492e-01 0.387 0 0
MTOR signalling R-HSA-165159 4.100492e-01 0.387 0 0
Disorders of transmembrane transporters R-HSA-5619115 4.114362e-01 0.386 0 0
Generic Transcription Pathway R-HSA-212436 4.126506e-01 0.384 0 0
RSV-host interactions R-HSA-9833110 4.175623e-01 0.379 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.185753e-01 0.378 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.185753e-01 0.378 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.220121e-01 0.375 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.220121e-01 0.375 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.220121e-01 0.375 0 0
Platelet sensitization by LDL R-HSA-432142 4.220121e-01 0.375 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.222733e-01 0.374 0 0
LGI-ADAM interactions R-HSA-5682910 4.224633e-01 0.374 0 0
Formation of the posterior neural plate R-HSA-9832991 4.224633e-01 0.374 0 0
Interleukin-2 signaling R-HSA-9020558 4.224633e-01 0.374 0 0
Bicarbonate transporters R-HSA-425381 4.224633e-01 0.374 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.224633e-01 0.374 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.224633e-01 0.374 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 4.224633e-01 0.374 0 0
Signaling by SCF-KIT R-HSA-1433557 4.280734e-01 0.368 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.412406e-01 0.355 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.412406e-01 0.355 0 0
Maturation of hRSV A proteins R-HSA-9828806 4.412406e-01 0.355 0 0
RMTs methylate histone arginines R-HSA-3214858 4.460100e-01 0.351 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.488411e-01 0.348 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.488411e-01 0.348 0 0
Calmodulin induced events R-HSA-111933 4.541673e-01 0.343 0 0
CaM pathway R-HSA-111997 4.541673e-01 0.343 0 0
Triglyceride catabolism R-HSA-163560 4.541673e-01 0.343 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.570179e-01 0.340 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.570179e-01 0.340 0 0
ERKs are inactivated R-HSA-202670 4.570179e-01 0.340 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.570179e-01 0.340 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.570179e-01 0.340 0 0
Activation of RAC1 R-HSA-428540 4.570179e-01 0.340 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.570179e-01 0.340 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.609183e-01 0.336 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.609183e-01 0.336 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.609183e-01 0.336 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.609183e-01 0.336 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.609183e-01 0.336 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.609183e-01 0.336 0 0
Dopamine receptors R-HSA-390651 4.609183e-01 0.336 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.609183e-01 0.336 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.609183e-01 0.336 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.609183e-01 0.336 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.636356e-01 0.334 0 0
Inflammasomes R-HSA-622312 4.636356e-01 0.334 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.638258e-01 0.334 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.647606e-01 0.333 0 0
Signaling by ERBB4 R-HSA-1236394 4.691862e-01 0.329 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.751502e-01 0.323 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.751502e-01 0.323 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.751502e-01 0.323 0 0
Protein hydroxylation R-HSA-9629569 4.751502e-01 0.323 0 0
Signaling by Erythropoietin R-HSA-9006335 4.857042e-01 0.314 0 0
Leading Strand Synthesis R-HSA-69109 4.903439e-01 0.309 0 0
Polymerase switching R-HSA-69091 4.903439e-01 0.309 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.903439e-01 0.309 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.903439e-01 0.309 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.903439e-01 0.309 0 0
Signaling by LTK R-HSA-9842663 4.903439e-01 0.309 0 0
OAS antiviral response R-HSA-8983711 4.903439e-01 0.309 0 0
MET promotes cell motility R-HSA-8875878 4.931620e-01 0.307 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.989713e-01 0.302 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.989713e-01 0.302 0 0
G-protein activation R-HSA-202040 5.008635e-01 0.300 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.008635e-01 0.300 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.008635e-01 0.300 0 0
Basigin interactions R-HSA-210991 5.008635e-01 0.300 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.073963e-01 0.295 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.073963e-01 0.295 0 0
Activation of BH3-only proteins R-HSA-114452 5.073963e-01 0.295 0 0
Neddylation R-HSA-8951664 5.122409e-01 0.291 0 0
RAS processing R-HSA-9648002 5.122720e-01 0.290 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.122720e-01 0.290 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.136817e-01 0.289 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.136817e-01 0.289 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.136817e-01 0.289 0 0
G2 Phase R-HSA-68911 5.136817e-01 0.289 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.136817e-01 0.289 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 5.136817e-01 0.289 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.136817e-01 0.289 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.136817e-01 0.289 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.136817e-01 0.289 0 0
Reelin signalling pathway R-HSA-8866376 5.136817e-01 0.289 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.136817e-01 0.289 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.136817e-01 0.289 0 0
Co-inhibition by BTLA R-HSA-9927353 5.136817e-01 0.289 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.136817e-01 0.289 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.136817e-01 0.289 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.136817e-01 0.289 0 0
Co-stimulation by CD28 R-HSA-389356 5.162443e-01 0.287 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.223507e-01 0.282 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.223507e-01 0.282 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.223507e-01 0.282 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.223507e-01 0.282 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.223507e-01 0.282 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.223507e-01 0.282 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.223507e-01 0.282 0 0
Maturation of nucleoprotein R-HSA-9683610 5.223507e-01 0.282 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.259171e-01 0.279 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.259171e-01 0.279 0 0
Attachment and Entry R-HSA-9694614 5.259171e-01 0.279 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.259171e-01 0.279 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.259171e-01 0.279 0 0
Ribavirin ADME R-HSA-9755088 5.259171e-01 0.279 0 0
Peroxisomal protein import R-HSA-9033241 5.353361e-01 0.271 0 0
SLC transporter disorders R-HSA-5619102 5.354352e-01 0.271 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.494788e-01 0.260 0 0
Signaling by WNT in cancer R-HSA-4791275 5.494788e-01 0.260 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.494788e-01 0.260 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.494788e-01 0.260 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.495537e-01 0.260 0 0
PI3K Cascade R-HSA-109704 5.500642e-01 0.260 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.502581e-01 0.259 0 0
Notch-HLH transcription pathway R-HSA-350054 5.502581e-01 0.259 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.502581e-01 0.259 0 0
mTORC1-mediated signalling R-HSA-166208 5.502581e-01 0.259 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.502581e-01 0.259 0 0
tRNA Aminoacylation R-HSA-379724 5.508175e-01 0.259 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.529775e-01 0.257 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.529775e-01 0.257 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.529775e-01 0.257 0 0
Physiological factors R-HSA-5578768 5.529775e-01 0.257 0 0
Plus-strand DNA synthesis R-HSA-164525 5.612836e-01 0.251 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.612836e-01 0.251 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.612836e-01 0.251 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.612836e-01 0.251 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.612836e-01 0.251 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.612836e-01 0.251 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.612836e-01 0.251 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.612836e-01 0.251 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.612836e-01 0.251 0 0
TRAIL signaling R-HSA-75158 5.612836e-01 0.251 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.612836e-01 0.251 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.612836e-01 0.251 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.612836e-01 0.251 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.612836e-01 0.251 0 0
Signaling by MST1 R-HSA-8852405 5.612836e-01 0.251 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.612836e-01 0.251 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.612836e-01 0.251 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.612836e-01 0.251 0 0
Ion channel transport R-HSA-983712 5.654887e-01 0.248 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.676694e-01 0.246 0 0
G-protein beta:gamma signalling R-HSA-397795 5.697967e-01 0.244 0 0
Nuclear RNA decay R-HSA-9930044 5.697967e-01 0.244 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.697967e-01 0.244 0 0
Cardiogenesis R-HSA-9733709 5.697967e-01 0.244 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.738443e-01 0.241 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.738443e-01 0.241 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.738443e-01 0.241 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 5.738443e-01 0.241 0 0
Growth hormone receptor signaling R-HSA-982772 5.738443e-01 0.241 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.816029e-01 0.235 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.821876e-01 0.235 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.821876e-01 0.235 0 0
p38MAPK events R-HSA-171007 5.821876e-01 0.235 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.821876e-01 0.235 0 0
Ca-dependent events R-HSA-111996 5.854029e-01 0.233 0 0
Rab regulation of trafficking R-HSA-9007101 5.900510e-01 0.229 0 0
Protein localization R-HSA-9609507 5.902327e-01 0.229 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.924366e-01 0.227 0 0
Ca2+ pathway R-HSA-4086398 5.938505e-01 0.226 0 0
Interleukin-6 family signaling R-HSA-6783589 5.966425e-01 0.224 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.966425e-01 0.224 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.966425e-01 0.224 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.966425e-01 0.224 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.042287e-01 0.219 0 0
STAT5 Activation R-HSA-9645135 6.042287e-01 0.219 0 0
Uncoating of the HIV Virion R-HSA-162585 6.042287e-01 0.219 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.042287e-01 0.219 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.042287e-01 0.219 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.042287e-01 0.219 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.042287e-01 0.219 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.042287e-01 0.219 0 0
CREB phosphorylation R-HSA-199920 6.042287e-01 0.219 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.042287e-01 0.219 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.042287e-01 0.219 0 0
Lactose synthesis R-HSA-5653890 6.042287e-01 0.219 0 0
Leukotriene receptors R-HSA-391906 6.042287e-01 0.219 0 0
HDL clearance R-HSA-8964011 6.042287e-01 0.219 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.042287e-01 0.219 0 0
Nef and signal transduction R-HSA-164944 6.042287e-01 0.219 0 0
MET Receptor Activation R-HSA-6806942 6.042287e-01 0.219 0 0
Signaling by FGFR in disease R-HSA-1226099 6.074576e-01 0.216 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.088427e-01 0.215 0 0
Signal amplification R-HSA-392518 6.088427e-01 0.215 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.099651e-01 0.215 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.099651e-01 0.215 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.099651e-01 0.215 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.099651e-01 0.215 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.099651e-01 0.215 0 0
Killing mechanisms R-HSA-9664420 6.099651e-01 0.215 0 0
Attachment and Entry R-HSA-9678110 6.099651e-01 0.215 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.099651e-01 0.215 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.099651e-01 0.215 0 0
Activation of SMO R-HSA-5635838 6.099651e-01 0.215 0 0
Transmission across Chemical Synapses R-HSA-112315 6.118156e-01 0.213 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.186284e-01 0.209 0 0
Interleukin-7 signaling R-HSA-1266695 6.186284e-01 0.209 0 0
TGFBR3 expression R-HSA-9839394 6.186284e-01 0.209 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.186284e-01 0.209 0 0
Amine ligand-binding receptors R-HSA-375280 6.196446e-01 0.208 0 0
PERK regulates gene expression R-HSA-381042 6.275277e-01 0.202 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.361206e-01 0.196 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.361206e-01 0.196 0 0
DAG and IP3 signaling R-HSA-1489509 6.361206e-01 0.196 0 0
Coenzyme A biosynthesis R-HSA-196783 6.363104e-01 0.196 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.363104e-01 0.196 0 0
Response to metal ions R-HSA-5660526 6.363104e-01 0.196 0 0
Myogenesis R-HSA-525793 6.397853e-01 0.194 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.397853e-01 0.194 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.429722e-01 0.192 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.429722e-01 0.192 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.429722e-01 0.192 0 0
Disinhibition of SNARE formation R-HSA-114516 6.429722e-01 0.192 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.429722e-01 0.192 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.429722e-01 0.192 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.429722e-01 0.192 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.429722e-01 0.192 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.429722e-01 0.192 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.429722e-01 0.192 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.429722e-01 0.192 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.456326e-01 0.190 0 0
RNA Polymerase III Transcription R-HSA-74158 6.456326e-01 0.190 0 0
GPVI-mediated activation cascade R-HSA-114604 6.456326e-01 0.190 0 0
G1/S-Specific Transcription R-HSA-69205 6.456326e-01 0.190 0 0
Cardiac conduction R-HSA-5576891 6.505325e-01 0.187 0 0
G-protein mediated events R-HSA-112040 6.520533e-01 0.186 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.521494e-01 0.186 0 0
Signaling by TGFBR3 R-HSA-9839373 6.521494e-01 0.186 0 0
IRS-mediated signalling R-HSA-112399 6.587917e-01 0.181 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.601031e-01 0.180 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.601031e-01 0.180 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.601031e-01 0.180 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.612378e-01 0.180 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.612378e-01 0.180 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.612378e-01 0.180 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.612378e-01 0.180 0 0
Transcription of the HIV genome R-HSA-167172 6.653540e-01 0.177 0 0
Regulated Necrosis R-HSA-5218859 6.653540e-01 0.177 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.656203e-01 0.177 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.747522e-01 0.171 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.779251e-01 0.169 0 0
Minus-strand DNA synthesis R-HSA-164516 6.779251e-01 0.169 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.779251e-01 0.169 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.779251e-01 0.169 0 0
Regulation by c-FLIP R-HSA-3371378 6.779251e-01 0.169 0 0
Dimerization of procaspase-8 R-HSA-69416 6.779251e-01 0.169 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.779251e-01 0.169 0 0
MET receptor recycling R-HSA-8875656 6.779251e-01 0.169 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.779251e-01 0.169 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.779251e-01 0.169 0 0
Interleukin-9 signaling R-HSA-8985947 6.779251e-01 0.169 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.779251e-01 0.169 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.779251e-01 0.169 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.779251e-01 0.169 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.779251e-01 0.169 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.779251e-01 0.169 0 0
Sodium/Proton exchangers R-HSA-425986 6.779251e-01 0.169 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.779251e-01 0.169 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.795781e-01 0.168 0 0
HIV elongation arrest and recovery R-HSA-167287 6.795781e-01 0.168 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.795781e-01 0.168 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.795781e-01 0.168 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.795781e-01 0.168 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.800605e-01 0.167 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.800605e-01 0.167 0 0
Developmental Cell Lineages R-HSA-9734767 6.808307e-01 0.167 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.809611e-01 0.167 0 0
GPER1 signaling R-HSA-9634597 6.828292e-01 0.166 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.828292e-01 0.166 0 0
NGF-stimulated transcription R-HSA-9031628 6.828292e-01 0.166 0 0
Metal ion SLC transporters R-HSA-425410 6.828292e-01 0.166 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.838131e-01 0.165 0 0
Regulation of insulin secretion R-HSA-422356 6.839651e-01 0.165 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.847723e-01 0.164 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.847723e-01 0.164 0 0
Mismatch Repair R-HSA-5358508 6.847723e-01 0.164 0 0
Polo-like kinase mediated events R-HSA-156711 6.847723e-01 0.164 0 0
Nephron development R-HSA-9831926 6.847723e-01 0.164 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.847723e-01 0.164 0 0
Hemostasis R-HSA-109582 6.848243e-01 0.164 0 0
FCERI mediated NF-kB activation R-HSA-2871837 6.939997e-01 0.159 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.955924e-01 0.158 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.963715e-01 0.157 0 0
Pentose phosphate pathway R-HSA-71336 6.963715e-01 0.157 0 0
Signaling by ALK R-HSA-201556 6.963715e-01 0.157 0 0
mRNA Capping R-HSA-72086 6.982119e-01 0.156 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.982119e-01 0.156 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.982119e-01 0.156 0 0
Platelet calcium homeostasis R-HSA-418360 6.982119e-01 0.156 0 0
Glucagon-type ligand receptors R-HSA-420092 6.982119e-01 0.156 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.069477e-01 0.151 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.069477e-01 0.151 0 0
Maturation of nucleoprotein R-HSA-9694631 7.069477e-01 0.151 0 0
Interleukin-21 signaling R-HSA-9020958 7.094579e-01 0.149 0 0
WNT mediated activation of DVL R-HSA-201688 7.094579e-01 0.149 0 0
CASP8 activity is inhibited R-HSA-5218900 7.094579e-01 0.149 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.094579e-01 0.149 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.094579e-01 0.149 0 0
mRNA Editing R-HSA-75072 7.094579e-01 0.149 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.094579e-01 0.149 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.094579e-01 0.149 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.094579e-01 0.149 0 0
Interleukin-1 processing R-HSA-448706 7.094579e-01 0.149 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.120778e-01 0.147 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.120778e-01 0.147 0 0
HIV Transcription Elongation R-HSA-167169 7.120778e-01 0.147 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.120778e-01 0.147 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.120778e-01 0.147 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.120778e-01 0.147 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.120778e-01 0.147 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.129847e-01 0.147 0 0
PLC beta mediated events R-HSA-112043 7.129847e-01 0.147 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.153444e-01 0.145 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.160108e-01 0.145 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.160108e-01 0.145 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.160108e-01 0.145 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.160108e-01 0.145 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.160108e-01 0.145 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.182967e-01 0.144 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.255642e-01 0.139 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.271807e-01 0.138 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.276213e-01 0.138 0 0
Signaling by NODAL R-HSA-1181150 7.278045e-01 0.138 0 0
Formation of definitive endoderm R-HSA-9823730 7.278045e-01 0.138 0 0
Interferon gamma signaling R-HSA-877300 7.319880e-01 0.135 0 0
Downstream signal transduction R-HSA-186763 7.329851e-01 0.135 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.379052e-01 0.132 0 0
Interleukin-27 signaling R-HSA-9020956 7.379052e-01 0.132 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.379052e-01 0.132 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.379052e-01 0.132 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.379052e-01 0.132 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.398459e-01 0.131 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.416839e-01 0.130 0 0
HIV Transcription Initiation R-HSA-167161 7.416839e-01 0.130 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.416839e-01 0.130 0 0
Intra-Golgi traffic R-HSA-6811438 7.416839e-01 0.130 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.419006e-01 0.130 0 0
Disease R-HSA-1643685 7.460230e-01 0.127 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.473883e-01 0.126 0 0
Lagging Strand Synthesis R-HSA-69186 7.473883e-01 0.126 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.473883e-01 0.126 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.473883e-01 0.126 0 0
ERK/MAPK targets R-HSA-198753 7.473883e-01 0.126 0 0
Signalling to RAS R-HSA-167044 7.473883e-01 0.126 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.482171e-01 0.126 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.493687e-01 0.125 0 0
Iron uptake and transport R-HSA-917937 7.493687e-01 0.125 0 0
IGF1R signaling cascade R-HSA-2428924 7.495494e-01 0.125 0 0
Insulin receptor signalling cascade R-HSA-74751 7.495494e-01 0.125 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.498795e-01 0.125 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.512863e-01 0.124 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.589716e-01 0.120 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.609567e-01 0.119 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.635687e-01 0.117 0 0
vRNA Synthesis R-HSA-192814 7.635687e-01 0.117 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.635687e-01 0.117 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.635687e-01 0.117 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.635687e-01 0.117 0 0
Suppression of apoptosis R-HSA-9635465 7.635687e-01 0.117 0 0
Transport of RCbl within the body R-HSA-9758890 7.635687e-01 0.117 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.635687e-01 0.117 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.645179e-01 0.117 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.657483e-01 0.116 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.657483e-01 0.116 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.657483e-01 0.116 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.657483e-01 0.116 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.689173e-01 0.114 0 0
Translation of Structural Proteins R-HSA-9694635 7.703848e-01 0.113 0 0
G alpha (z) signalling events R-HSA-418597 7.753755e-01 0.110 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.791124e-01 0.108 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.791124e-01 0.108 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.791124e-01 0.108 0 0
Heme degradation R-HSA-189483 7.791124e-01 0.108 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.791124e-01 0.108 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.829365e-01 0.106 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.829365e-01 0.106 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.829365e-01 0.106 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.829365e-01 0.106 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.829365e-01 0.106 0 0
Signaling by KIT in disease R-HSA-9669938 7.829365e-01 0.106 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.829365e-01 0.106 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.867207e-01 0.104 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.867207e-01 0.104 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.867207e-01 0.104 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.867207e-01 0.104 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.867207e-01 0.104 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.867207e-01 0.104 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.867207e-01 0.104 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.867300e-01 0.104 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.867300e-01 0.104 0 0
Stimuli-sensing channels R-HSA-2672351 7.882840e-01 0.103 0 0
Mitochondrial biogenesis R-HSA-1592230 7.889493e-01 0.103 0 0
Integration of energy metabolism R-HSA-163685 7.913110e-01 0.102 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.929532e-01 0.101 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.938475e-01 0.100 0 0
Somitogenesis R-HSA-9824272 7.938475e-01 0.100 0 0
Interleukin-20 family signaling R-HSA-8854691 7.990061e-01 0.097 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.990061e-01 0.097 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.990061e-01 0.097 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.990061e-01 0.097 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.054771e-01 0.094 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.054771e-01 0.094 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.054771e-01 0.094 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.060632e-01 0.094 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.060632e-01 0.094 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.076068e-01 0.093 0 0
Interleukin-15 signaling R-HSA-8983432 8.076068e-01 0.093 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.076068e-01 0.093 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.076068e-01 0.093 0 0
Interleukin-35 Signalling R-HSA-8984722 8.076068e-01 0.093 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.076068e-01 0.093 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.076068e-01 0.093 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.076068e-01 0.093 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.076068e-01 0.093 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.076068e-01 0.093 0 0
Metabolism of proteins R-HSA-392499 8.076621e-01 0.093 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.080930e-01 0.093 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.127769e-01 0.090 0 0
Gastrulation R-HSA-9758941 8.130271e-01 0.090 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.140114e-01 0.089 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.140114e-01 0.089 0 0
Complex III assembly R-HSA-9865881 8.140114e-01 0.089 0 0
Triglyceride metabolism R-HSA-8979227 8.181179e-01 0.087 0 0
RUNX2 regulates bone development R-HSA-8941326 8.184665e-01 0.087 0 0
Glycosphingolipid transport R-HSA-9845576 8.184665e-01 0.087 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.225083e-01 0.085 0 0
Formation of axial mesoderm R-HSA-9796292 8.264486e-01 0.083 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.264486e-01 0.083 0 0
Processing of SMDT1 R-HSA-8949664 8.264486e-01 0.083 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.264486e-01 0.083 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.264486e-01 0.083 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.264486e-01 0.083 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.264486e-01 0.083 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.280066e-01 0.082 0 0
G protein gated Potassium channels R-HSA-1296059 8.280066e-01 0.082 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.280066e-01 0.082 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.280066e-01 0.082 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.280066e-01 0.082 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.280066e-01 0.082 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.301881e-01 0.081 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.301942e-01 0.081 0 0
Aquaporin-mediated transport R-HSA-445717 8.369011e-01 0.077 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.410458e-01 0.075 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.410458e-01 0.075 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.410458e-01 0.075 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.410458e-01 0.075 0 0
TRP channels R-HSA-3295583 8.410458e-01 0.075 0 0
Elastic fibre formation R-HSA-1566948 8.412536e-01 0.075 0 0
Removal of the Flap Intermediate R-HSA-69166 8.434462e-01 0.074 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.434462e-01 0.074 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.434462e-01 0.074 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.434462e-01 0.074 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.434462e-01 0.074 0 0
cGMP effects R-HSA-418457 8.434462e-01 0.074 0 0
Prolactin receptor signaling R-HSA-1170546 8.434462e-01 0.074 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.434462e-01 0.074 0 0
Malate-aspartate shuttle R-HSA-9856872 8.434462e-01 0.074 0 0
HDL assembly R-HSA-8963896 8.434462e-01 0.074 0 0
Mitochondrial protein import R-HSA-1268020 8.456798e-01 0.073 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.456798e-01 0.073 0 0
Azathioprine ADME R-HSA-9748787 8.467474e-01 0.072 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.516893e-01 0.070 0 0
Cristae formation R-HSA-8949613 8.531817e-01 0.069 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.531817e-01 0.069 0 0
Insulin processing R-HSA-264876 8.531817e-01 0.069 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.531817e-01 0.069 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.540642e-01 0.069 0 0
Platelet homeostasis R-HSA-418346 8.554778e-01 0.068 0 0
The phototransduction cascade R-HSA-2514856 8.558290e-01 0.068 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.587800e-01 0.066 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.587800e-01 0.066 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.587800e-01 0.066 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.587800e-01 0.066 0 0
Protein lipoylation R-HSA-9857492 8.587800e-01 0.066 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.587800e-01 0.066 0 0
DNA Damage Reversal R-HSA-73942 8.587800e-01 0.066 0 0
Signaling by Activin R-HSA-1502540 8.587800e-01 0.066 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.587800e-01 0.066 0 0
Transport and metabolism of PAPS R-HSA-174362 8.587800e-01 0.066 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.587800e-01 0.066 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.587800e-01 0.066 0 0
Other semaphorin interactions R-HSA-416700 8.587800e-01 0.066 0 0
Generation of second messenger molecules R-HSA-202433 8.615212e-01 0.065 0 0
Neurexins and neuroligins R-HSA-6794361 8.644485e-01 0.063 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.644663e-01 0.063 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.644663e-01 0.063 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.726127e-01 0.059 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.726127e-01 0.059 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.726127e-01 0.059 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.726127e-01 0.059 0 0
Mitochondrial Uncoupling R-HSA-166187 8.726127e-01 0.059 0 0
Atorvastatin ADME R-HSA-9754706 8.726127e-01 0.059 0 0
Virus Assembly and Release R-HSA-168268 8.726127e-01 0.059 0 0
Nucleotide biosynthesis R-HSA-8956320 8.726222e-01 0.059 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.749497e-01 0.058 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.749497e-01 0.058 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.838869e-01 0.054 0 0
DAP12 signaling R-HSA-2424491 8.846808e-01 0.053 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.846808e-01 0.053 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.846808e-01 0.053 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.850912e-01 0.053 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.850912e-01 0.053 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.850912e-01 0.053 0 0
Glycine degradation R-HSA-6783984 8.850912e-01 0.053 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.850912e-01 0.053 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.850912e-01 0.053 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.850912e-01 0.053 0 0
Phase 2 - plateau phase R-HSA-5576893 8.850912e-01 0.053 0 0
Passive transport by Aquaporins R-HSA-432047 8.850912e-01 0.053 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.850912e-01 0.053 0 0
Galactose catabolism R-HSA-70370 8.850912e-01 0.053 0 0
Activation of GABAB receptors R-HSA-991365 8.876573e-01 0.052 0 0
GABA B receptor activation R-HSA-977444 8.876573e-01 0.052 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.937061e-01 0.049 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.937061e-01 0.049 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.939507e-01 0.049 0 0
PI Metabolism R-HSA-1483255 8.941067e-01 0.049 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.963481e-01 0.048 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.963481e-01 0.048 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.963481e-01 0.048 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.020706e-01 0.045 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.065027e-01 0.043 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.065027e-01 0.043 0 0
PKA activation R-HSA-163615 9.065027e-01 0.043 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.065027e-01 0.043 0 0
PKA activation in glucagon signalling R-HSA-164378 9.065027e-01 0.043 0 0
Tie2 Signaling R-HSA-210993 9.065027e-01 0.043 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.065027e-01 0.043 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.073870e-01 0.042 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.132339e-01 0.039 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.132339e-01 0.039 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.136895e-01 0.039 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.156631e-01 0.038 0 0
Specification of the neural plate border R-HSA-9834899 9.156631e-01 0.038 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.156631e-01 0.038 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.156631e-01 0.038 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.156631e-01 0.038 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.156631e-01 0.038 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.169864e-01 0.038 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.169864e-01 0.038 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.187493e-01 0.037 0 0
Metabolism of polyamines R-HSA-351202 9.187493e-01 0.037 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.187712e-01 0.037 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.203336e-01 0.036 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.236171e-01 0.035 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.239265e-01 0.034 0 0
Creatine metabolism R-HSA-71288 9.239265e-01 0.034 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.239265e-01 0.034 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.239265e-01 0.034 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.239486e-01 0.034 0 0
Neuronal System R-HSA-112316 9.243308e-01 0.034 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.276473e-01 0.033 0 0
Signaling by PDGF R-HSA-186797 9.288467e-01 0.032 0 0
Abacavir metabolism R-HSA-2161541 9.313806e-01 0.031 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.313806e-01 0.031 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.313806e-01 0.031 0 0
FOXO-mediated transcription R-HSA-9614085 9.344644e-01 0.029 0 0
Adipogenesis R-HSA-9843745 9.352783e-01 0.029 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.354076e-01 0.029 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.365472e-01 0.028 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.370866e-01 0.028 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.381048e-01 0.028 0 0
Neurotransmitter release cycle R-HSA-112310 9.404292e-01 0.027 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.406347e-01 0.027 0 0
Post-translational protein modification R-HSA-597592 9.430798e-01 0.025 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.440553e-01 0.025 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.441704e-01 0.025 0 0
Cellular hexose transport R-HSA-189200 9.441704e-01 0.025 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.441704e-01 0.025 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.441704e-01 0.025 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.441704e-01 0.025 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.454581e-01 0.024 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.457118e-01 0.024 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.458154e-01 0.024 0 0
Kidney development R-HSA-9830369 9.493135e-01 0.023 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.496419e-01 0.022 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.496419e-01 0.022 0 0
Formation of the ureteric bud R-HSA-9830674 9.496419e-01 0.022 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.496419e-01 0.022 0 0
Carnitine shuttle R-HSA-200425 9.496419e-01 0.022 0 0
Signaling by Insulin receptor R-HSA-74752 9.501919e-01 0.022 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.501919e-01 0.022 0 0
Interleukin-2 family signaling R-HSA-451927 9.540075e-01 0.020 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.540075e-01 0.020 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.545774e-01 0.020 0 0
Hyaluronan degradation R-HSA-2160916 9.590295e-01 0.018 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.590295e-01 0.018 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.590295e-01 0.018 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.612660e-01 0.017 0 0
Dectin-2 family R-HSA-5621480 9.629504e-01 0.016 0 0
MET activates PTK2 signaling R-HSA-8874081 9.630455e-01 0.016 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.630455e-01 0.016 0 0
Abacavir ADME R-HSA-2161522 9.630455e-01 0.016 0 0
Sphingolipid catabolism R-HSA-9845614 9.630455e-01 0.016 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.633020e-01 0.016 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.666680e-01 0.015 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.666680e-01 0.015 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.666680e-01 0.015 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.666974e-01 0.015 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.675999e-01 0.014 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.699356e-01 0.013 0 0
Pyroptosis R-HSA-5620971 9.699356e-01 0.013 0 0
DAP12 interactions R-HSA-2172127 9.701294e-01 0.013 0 0
GABA receptor activation R-HSA-977443 9.706312e-01 0.013 0 0
Formation of the cornified envelope R-HSA-6809371 9.723101e-01 0.012 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.728831e-01 0.012 0 0
Neurotransmitter clearance R-HSA-112311 9.755418e-01 0.011 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.767447e-01 0.010 0 0
Integrin cell surface interactions R-HSA-216083 9.767447e-01 0.010 0 0
Cargo concentration in the ER R-HSA-5694530 9.779399e-01 0.010 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.806009e-01 0.009 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.807305e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.818931e-01 0.008 0 0
Mitochondrial protein degradation R-HSA-9837999 9.818931e-01 0.008 0 0
Recycling of bile acids and salts R-HSA-159418 9.820541e-01 0.008 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.820541e-01 0.008 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.838140e-01 0.007 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.850447e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.851800e-01 0.006 0 0
Hyaluronan metabolism R-HSA-2142845 9.854014e-01 0.006 0 0
eNOS activation R-HSA-203615 9.854014e-01 0.006 0 0
Parasitic Infection Pathways R-HSA-9824443 9.862201e-01 0.006 0 0
Leishmania infection R-HSA-9658195 9.862201e-01 0.006 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.864872e-01 0.006 0 0
COPII-mediated vesicle transport R-HSA-204005 9.867283e-01 0.006 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.868219e-01 0.006 0 0
Metabolism of porphyrins R-HSA-189445 9.877603e-01 0.005 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.880529e-01 0.005 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.881247e-01 0.005 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.881247e-01 0.005 0 0
Paracetamol ADME R-HSA-9753281 9.886986e-01 0.005 0 0
Voltage gated Potassium channels R-HSA-1296072 9.892896e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.892896e-01 0.005 0 0
Metabolism of folate and pterines R-HSA-196757 9.892896e-01 0.005 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.899983e-01 0.004 0 0
Synthesis of PA R-HSA-1483166 9.905554e-01 0.004 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.911769e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.911874e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.911874e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.911874e-01 0.004 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.912879e-01 0.004 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.917237e-01 0.004 0 0
Regulation of beta-cell development R-HSA-186712 9.921131e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.921426e-01 0.003 0 0
RAB geranylgeranylation R-HSA-8873719 9.927946e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.927946e-01 0.003 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.929135e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.929135e-01 0.003 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.936088e-01 0.003 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.936496e-01 0.003 0 0
G alpha (s) signalling events R-HSA-418555 9.937964e-01 0.003 0 0
Innate Immune System R-HSA-168249 9.938591e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.944975e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.944975e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.946919e-01 0.002 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.948194e-01 0.002 0 0
Potassium Channels R-HSA-1296071 9.952435e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.953118e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.953118e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.953118e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.956868e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.957719e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.965239e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.965611e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.968443e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.970305e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.972031e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.973618e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.976817e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.977253e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.977253e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.977253e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.978063e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.983564e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.986024e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.986201e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.986201e-01 0.001 0 0
Digestion R-HSA-8935690 9.986433e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.988120e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.991910e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.991910e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.993421e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.993421e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.994068e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.995650e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.995650e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996078e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.996464e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.996811e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.996811e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.996968e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997124e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997407e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.997892e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.997892e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.998031e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998086e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998561e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998595e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.998606e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999025e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999186e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999260e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999544e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999586e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999614e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999701e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999703e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999717e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999842e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999855e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999871e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999876e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999888e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999917e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999923e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999931e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999938e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999963e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999963e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999965e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999984e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999987e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999989e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999993e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999993e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999993e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999993e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999997e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999997e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999998e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999998e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways