MEK5

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
O95373 T968 Sugiyama IPO7 RANBP7 IIDDEDNPVDEYQIFKAIFQtIQNRNPVWyQALTHGLNEEQ
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 S37 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07900 S263 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0DPH7 T334 Sugiyama TUBA3C TUBA2 ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P32969 S182 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 QQATTVKNKDIRKFLDGIyVsEKGtVQQADE__________
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38117 T172 Sugiyama ETFB FP585 QVTLEGDKLKVEREIDGGLEtLRLKLPAVVTADLRLNEPRy
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P55854 S27 Sugiyama SUMO3 SMT3A SMT3H1 KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61956 S28 Sugiyama SUMO2 SMT3B SMT3H2 EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 T334 Sugiyama TUBA1B ACCLLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVG
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q13163 S129 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 CKPPGERNIHGLKVNtRAGPsQHssPAVsDsLPsNsLKKss
Q13163 S132 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 PGERNIHGLKVNtRAGPsQHssPAVsDsLPsNsLKKssAEL
Q13163 S139 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 GLKVNtRAGPsQHssPAVsDsLPsNsLKKssAELKKILANG
Q13163 S142 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 VNtRAGPsQHssPAVsDsLPsNsLKKssAELKKILANGQMN
Q13163 S144 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 tRAGPsQHssPAVsDsLPsNsLKKssAELKKILANGQMNEQ
Q13163 T124 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 IFPRACKPPGERNIHGLKVNtRAGPsQHssPAVsDsLPsNs
Q13163 T171 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 ELKKILANGQMNEQDIRYRDtLGHGNGGtVYKAYHVPSGKI
Q13163 T179 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 GQMNEQDIRYRDtLGHGNGGtVYKAYHVPSGKILAVKVILL
Q13163 T319 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 LCDFGVSTQLVNsIAKtyVGtNAyMAPERISGEQYGIHSDV
Q13163 Y316 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 QVKLCDFGVSTQLVNsIAKtyVGtNAyMAPERISGEQYGIH
Q13163 Y322 Sugiyama MAP2K5 MEK5 MKK5 PRKMK5 FGVSTQLVNsIAKtyVGtNAyMAPERISGEQYGIHSDVWSL
Q13164 T219 SIGNOR|EPSD|PSP MAPK7 BMK1 ERK5 PRKM7 GDFGMARGLCtsPAEHQYFMtEyVAtRWYRAPELMLSLHEY
Q13164 Y221 SIGNOR|EPSD|PSP MAPK7 BMK1 ERK5 PRKM7 FGMARGLCtsPAEHQYFMtEyVAtRWYRAPELMLSLHEYTQ
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6EEV6 S28 Sugiyama SUMO4 SMT3H4 EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6PEY2 T334 Sugiyama TUBA3E ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q71U36 T334 Sugiyama TUBA1A TUBA3 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q99759 S147 Sugiyama MAP3K3 MAPKKK3 MEKK3 HNsssPHSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsV
Q99759 S166 Sugiyama MAP3K3 MAPKKK3 MEKK3 QsAGDINtIyQPPEPRsRHLsVssQNPGRssPPPGYVPERQ
Q99759 S176 Sugiyama MAP3K3 MAPKKK3 MEKK3 QPPEPRsRHLsVssQNPGRssPPPGYVPERQQHIARQGSYT
Q99759 S337 Sugiyama MAP3K3 MAPKKK3 MEKK3 tNGENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPs
Q99759 S340 Sugiyama MAP3K3 MAPKKK3 MEKK3 ENMGLAVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPI
Q99759 S345 Sugiyama MAP3K3 MAPKKK3 MEKK3 AVQYLDPRGRLRsADsENALsVQERNVPTKsPsAPINWRRG
Q99759 T153 Sugiyama MAP3K3 MAPKKK3 MEKK3 HSGVSRQVRIKAsQsAGDINtIyQPPEPRsRHLsVssQNPG
Q9BQE3 T334 Sugiyama TUBA1C TUBA6 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9NY27 S311 Sugiyama PPP4R2 SBBI57 CTRQHCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDD
Q9NY27 S315 Sugiyama PPP4R2 SBBI57 HCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDDALTV
Q9NY27 T314 Sugiyama PPP4R2 SBBI57 QHCtEEDEEEDEEEEEEsFMtsREMIPERKNQEKESDDALT
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 3.967104e-11 10.402 1 0
Apoptotic execution phase R-HSA-75153 1.198081e-08 7.922 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.461345e-08 7.263 0 0
Signaling by Interleukins R-HSA-449147 1.666341e-07 6.778 0 0
Programmed Cell Death R-HSA-5357801 2.048084e-07 6.689 0 0
Apoptosis R-HSA-109581 8.268484e-07 6.083 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 9.173836e-07 6.037 0 0
Cellular Senescence R-HSA-2559583 4.909098e-06 5.309 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.310133e-06 5.275 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.429439e-06 5.265 0 0
Diseases of programmed cell death R-HSA-9645723 5.759525e-06 5.240 0 0
RAB geranylgeranylation R-HSA-8873719 6.521090e-06 5.186 0 0
Oncogene Induced Senescence R-HSA-2559585 7.112337e-06 5.148 0 0
Axon guidance R-HSA-422475 1.173342e-05 4.931 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.170319e-05 4.663 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.465637e-05 4.608 0 0
Immune System R-HSA-168256 4.949832e-05 4.305 0 0
Regulation of TP53 Activity R-HSA-5633007 5.751053e-05 4.240 0 0
Nervous system development R-HSA-9675108 5.857195e-05 4.232 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.803390e-05 4.055 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.803390e-05 4.055 0 0
MAPK family signaling cascades R-HSA-5683057 9.474494e-05 4.023 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.757527e-05 4.011 0 0
Signaling by Hippo R-HSA-2028269 1.010647e-04 3.995 0 0
Neurodegenerative Diseases R-HSA-8863678 1.101786e-04 3.958 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.101786e-04 3.958 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.156413e-04 3.937 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.156413e-04 3.937 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.363629e-04 3.865 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.440277e-04 3.842 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.569639e-04 3.804 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.779406e-04 3.750 0 0
Semaphorin interactions R-HSA-373755 1.829314e-04 3.738 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.192134e-04 3.659 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.347502e-04 3.629 0 0
Interleukin-12 signaling R-HSA-9020591 2.334859e-04 3.632 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.467327e-04 3.460 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.711418e-04 3.430 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.884001e-04 3.411 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.031543e-04 3.395 0 0
Innate Immune System R-HSA-168249 3.953617e-04 3.403 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.215348e-04 3.375 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.558143e-04 3.341 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.996203e-04 3.301 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.277740e-04 3.278 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.515597e-04 3.258 0 0
Toll-like Receptor Cascades R-HSA-168898 5.487692e-04 3.261 0 0
Cell junction organization R-HSA-446728 5.741992e-04 3.241 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.277141e-04 3.138 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.381568e-04 3.132 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.424994e-04 3.129 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.626462e-04 3.118 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.013462e-04 3.096 0 0
Interleukin-12 family signaling R-HSA-447115 7.995301e-04 3.097 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.473726e-04 3.072 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.473726e-04 3.072 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.473726e-04 3.072 0 0
Cell-Cell communication R-HSA-1500931 8.306894e-04 3.081 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.810157e-04 3.055 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 9.231819e-04 3.035 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.025902e-03 2.989 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.025902e-03 2.989 0 0
Signaling by NTRKs R-HSA-166520 1.158598e-03 2.936 1 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.170784e-03 2.932 0 0
EPH-Ephrin signaling R-HSA-2682334 1.366992e-03 2.864 0 0
Neutrophil degranulation R-HSA-6798695 1.506575e-03 2.822 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.549170e-03 2.810 0 0
Signaling by ERBB2 R-HSA-1227986 1.717291e-03 2.765 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.859378e-03 2.731 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.974917e-03 2.704 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.997303e-03 2.700 0 0
p75NTR signals via NF-kB R-HSA-193639 2.262187e-03 2.645 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.281578e-03 2.642 0 0
Cell Cycle R-HSA-1640170 2.342988e-03 2.630 0 0
Adherens junctions interactions R-HSA-418990 2.585051e-03 2.588 0 0
FOXO-mediated transcription R-HSA-9614085 2.609893e-03 2.583 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.843028e-03 2.546 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.001084e-03 2.523 1 0
Sensory processing of sound R-HSA-9659379 3.284724e-03 2.484 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.579607e-03 2.446 0 0
RAF activation R-HSA-5673000 3.694613e-03 2.432 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.760774e-03 2.425 0 0
Ion homeostasis R-HSA-5578775 3.824563e-03 2.417 0 0
Regulated Necrosis R-HSA-5218859 3.760774e-03 2.425 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.865027e-03 2.413 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.824563e-03 2.417 0 0
Interleukin-7 signaling R-HSA-1266695 3.863607e-03 2.413 0 0
Death Receptor Signaling R-HSA-73887 3.967304e-03 2.402 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 4.158163e-03 2.381 0 0
Myogenesis R-HSA-525793 4.495990e-03 2.347 0 0
Ephrin signaling R-HSA-3928664 5.050722e-03 2.297 0 0
Apoptotic factor-mediated response R-HSA-111471 5.050722e-03 2.297 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.201509e-03 2.284 0 0
Mitotic Prophase R-HSA-68875 5.338671e-03 2.273 0 0
Cell-cell junction organization R-HSA-421270 5.760168e-03 2.240 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.896852e-03 2.229 0 0
Pyroptosis R-HSA-5620971 5.984904e-03 2.223 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.359926e-03 2.133 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.359926e-03 2.133 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.359926e-03 2.133 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.359926e-03 2.133 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.359926e-03 2.133 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.359926e-03 2.133 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.359926e-03 2.133 0 0
Signaling by LTK R-HSA-9842663 7.359926e-03 2.133 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.581380e-03 2.120 0 0
Diseases of Immune System R-HSA-5260271 7.581380e-03 2.120 0 0
Signaling by VEGF R-HSA-194138 7.670996e-03 2.115 0 0
Interleukin-37 signaling R-HSA-9008059 7.804199e-03 2.108 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.322882e-03 2.080 0 0
G alpha (12/13) signalling events R-HSA-416482 8.604192e-03 2.065 0 0
Cell Cycle, Mitotic R-HSA-69278 9.018442e-03 2.045 0 0
Developmental Biology R-HSA-1266738 9.059118e-03 2.043 0 0
Cellular responses to stimuli R-HSA-8953897 8.657201e-03 2.063 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 9.070343e-03 2.042 0 0
Breakdown of the nuclear lamina R-HSA-352238 9.070343e-03 2.042 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 9.107496e-03 2.041 1 0
Cellular responses to stress R-HSA-2262752 9.140566e-03 2.039 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.380295e-03 2.028 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.679084e-03 2.014 0 0
Signaling by WNT in cancer R-HSA-4791275 9.991185e-03 2.000 0 0
Defective pyroptosis R-HSA-9710421 1.147301e-02 1.940 0 0
mTORC1-mediated signalling R-HSA-166208 1.117986e-02 1.952 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.080866e-02 1.966 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.117444e-02 1.952 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.200532e-02 1.921 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.223205e-02 1.913 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.223205e-02 1.913 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.263730e-02 1.898 0 0
Syndecan interactions R-HSA-3000170 1.283187e-02 1.892 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.306031e-02 1.884 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.312175e-02 1.882 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.418157e-02 1.848 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.464139e-02 1.834 0 0
Meiosis R-HSA-1500620 1.415668e-02 1.849 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.453552e-02 1.838 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.453552e-02 1.838 0 0
Generic Transcription Pathway R-HSA-212436 1.397963e-02 1.855 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.458388e-02 1.836 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.493010e-02 1.826 0 0
Regulation of TP53 Expression R-HSA-6804754 1.563487e-02 1.806 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.563487e-02 1.806 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.563487e-02 1.806 0 0
Diseases of cellular response to stress R-HSA-9675132 1.563487e-02 1.806 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.573220e-02 1.803 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.573220e-02 1.803 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.724536e-02 1.763 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.724536e-02 1.763 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.724536e-02 1.763 0 0
HDMs demethylate histones R-HSA-3214842 1.661436e-02 1.780 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.553636e-02 1.809 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.603883e-02 1.795 0 0
Signalling to ERKs R-HSA-187687 1.561124e-02 1.807 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.663173e-02 1.779 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.721950e-02 1.764 0 0
Muscle contraction R-HSA-397014 1.586527e-02 1.800 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.663173e-02 1.779 0 0
Interleukin-1 family signaling R-HSA-446652 1.675969e-02 1.776 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.815033e-02 1.741 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.821324e-02 1.740 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.821324e-02 1.740 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.837626e-02 1.736 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.973811e-02 1.705 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.973811e-02 1.705 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.973811e-02 1.705 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.973811e-02 1.705 0 0
Axonal growth stimulation R-HSA-209563 2.368981e-02 1.625 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.425387e-02 1.615 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.425387e-02 1.615 0 0
Signal attenuation R-HSA-74749 2.425387e-02 1.615 0 0
Regulation of CDH11 function R-HSA-9762292 2.425387e-02 1.615 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.396659e-02 1.620 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.438208e-02 1.613 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.477289e-02 1.606 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.530695e-02 1.597 0 0
Cell Cycle Checkpoints R-HSA-69620 2.546440e-02 1.594 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.579513e-02 1.588 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.624492e-02 1.581 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.624492e-02 1.581 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.776757e-02 1.556 0 0
Signaling by ALK in cancer R-HSA-9700206 2.776757e-02 1.556 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.308456e-02 1.480 0 0
NADE modulates death signalling R-HSA-205025 3.308456e-02 1.480 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.308456e-02 1.480 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.308456e-02 1.480 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.927944e-02 1.533 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.927944e-02 1.533 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.927944e-02 1.533 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.927944e-02 1.533 0 0
MTOR signalling R-HSA-165159 3.271408e-02 1.485 0 0
Interleukin-2 signaling R-HSA-9020558 2.927944e-02 1.533 0 0
Signaling by APC mutants R-HSA-4839744 2.927944e-02 1.533 0 0
NRAGE signals death through JNK R-HSA-193648 3.384474e-02 1.471 0 0
RNA Polymerase II Transcription R-HSA-73857 3.417410e-02 1.466 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.445983e-02 1.463 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.481123e-02 1.458 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.481123e-02 1.458 0 0
NF-kB is activated and signals survival R-HSA-209560 3.481123e-02 1.458 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.481123e-02 1.458 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.481123e-02 1.458 0 0
Signaling by AXIN mutants R-HSA-4839735 3.481123e-02 1.458 0 0
Signalling to RAS R-HSA-167044 3.574783e-02 1.447 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.629902e-02 1.440 0 0
IRS activation R-HSA-74713 4.367922e-02 1.360 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.084245e-02 1.389 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.084245e-02 1.389 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.084245e-02 1.389 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.084245e-02 1.389 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.084245e-02 1.389 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.641711e-02 1.439 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.641711e-02 1.439 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.367922e-02 1.360 0 0
Integrin signaling R-HSA-354192 3.885437e-02 1.411 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.084245e-02 1.389 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.885437e-02 1.411 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.367922e-02 1.360 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.035046e-02 1.394 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.367922e-02 1.360 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 4.367922e-02 1.360 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.367922e-02 1.360 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.084245e-02 1.389 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.885437e-02 1.411 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.011166e-02 1.397 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.011166e-02 1.397 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.084245e-02 1.389 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.249431e-02 1.372 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.641711e-02 1.439 0 0
PTEN Regulation R-HSA-6807070 3.644817e-02 1.438 0 0
NrCAM interactions R-HSA-447038 4.367922e-02 1.360 0 0
Netrin-1 signaling R-HSA-373752 3.835985e-02 1.416 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.459060e-02 1.351 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.459060e-02 1.351 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.459060e-02 1.351 0 0
Signaling by RAS mutants R-HSA-6802949 4.459060e-02 1.351 0 0
Signaling by TGFBR3 R-HSA-9839373 4.459060e-02 1.351 0 0
M Phase R-HSA-68886 4.567834e-02 1.340 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 4.598266e-02 1.337 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 4.598266e-02 1.337 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 4.598266e-02 1.337 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 4.598266e-02 1.337 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 4.598266e-02 1.337 0 0
L1CAM interactions R-HSA-373760 4.704810e-02 1.327 0 0
MAP kinase activation R-HSA-450294 4.722221e-02 1.326 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.534387e-02 1.257 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.534387e-02 1.257 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.534387e-02 1.257 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.736358e-02 1.325 0 0
Formation of axial mesoderm R-HSA-9796292 4.736358e-02 1.325 0 0
Deadenylation of mRNA R-HSA-429947 5.493673e-02 1.260 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.493673e-02 1.260 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.460904e-02 1.263 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.904728e-02 1.229 0 0
IGF1R signaling cascade R-HSA-2428924 5.666655e-02 1.247 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.534387e-02 1.257 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.904728e-02 1.229 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.534387e-02 1.257 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.534387e-02 1.257 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.534387e-02 1.257 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.736358e-02 1.325 0 0
RET signaling R-HSA-8853659 5.460904e-02 1.263 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.792919e-02 1.319 0 0
Ion transport by P-type ATPases R-HSA-936837 5.666655e-02 1.247 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.534387e-02 1.257 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.009045e-02 1.300 0 0
Chromatin modifying enzymes R-HSA-3247509 5.980215e-02 1.223 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.005667e-02 1.221 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.114244e-02 1.214 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.182591e-02 1.209 0 0
p38MAPK events R-HSA-171007 6.182591e-02 1.209 0 0
Amyloid fiber formation R-HSA-977225 6.268895e-02 1.203 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.320349e-02 1.199 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.368526e-02 1.196 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.624836e-02 1.179 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.795798e-02 1.168 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.795798e-02 1.168 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.829580e-02 1.166 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.852217e-02 1.164 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.943663e-02 1.158 0 0
Activation of SMO R-HSA-5635838 6.973749e-02 1.157 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.973749e-02 1.157 0 0
Meiotic synapsis R-HSA-1221632 7.113890e-02 1.148 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 8.985358e-02 1.046 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 8.985358e-02 1.046 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 8.985358e-02 1.046 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 8.985358e-02 1.046 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 8.985358e-02 1.046 0 0
TICAM1 deficiency - HSE R-HSA-5602566 8.985358e-02 1.046 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 8.985358e-02 1.046 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 8.985358e-02 1.046 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 8.985358e-02 1.046 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 8.985358e-02 1.046 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.140982e-02 1.089 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.140982e-02 1.089 0 0
SOS-mediated signalling R-HSA-112412 8.140982e-02 1.089 0 0
Disinhibition of SNARE formation R-HSA-114516 8.140982e-02 1.089 0 0
Recycling of eIF2:GDP R-HSA-72731 8.140982e-02 1.089 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 9.559591e-02 1.020 0 0
Type I hemidesmosome assembly R-HSA-446107 9.559591e-02 1.020 0 0
FGFR1b ligand binding and activation R-HSA-190370 9.559591e-02 1.020 0 0
Activation of RAS in B cells R-HSA-1169092 9.559591e-02 1.020 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 9.216425e-02 1.035 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.421227e-02 1.075 0 0
Translation initiation complex formation R-HSA-72649 7.553902e-02 1.122 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.483931e-02 1.126 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.464099e-02 1.024 0 0
Signaling by FGFR1 R-HSA-5654736 8.479174e-02 1.072 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.296490e-02 1.081 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 9.559591e-02 1.020 0 0
MAP2K and MAPK activation R-HSA-5674135 8.421227e-02 1.075 0 0
Aggrephagy R-HSA-9646399 7.355678e-02 1.133 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.272375e-02 1.138 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.216425e-02 1.035 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.721044e-02 1.059 0 0
Adipogenesis R-HSA-9843745 9.194262e-02 1.036 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.565149e-02 1.067 0 0
Activation and oligomerization of BAK protein R-HSA-111452 8.985358e-02 1.046 0 0
Chromatin organization R-HSA-4839726 9.014076e-02 1.045 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.884105e-02 1.103 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.355678e-02 1.133 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.355678e-02 1.133 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 7.878749e-02 1.104 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.306362e-02 1.081 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 8.985358e-02 1.046 0 0
SDK interactions R-HSA-373756 8.985358e-02 1.046 0 0
Inhibition of PKR R-HSA-169131 8.985358e-02 1.046 0 0
Platelet calcium homeostasis R-HSA-418360 8.528682e-02 1.069 0 0
Interleukin-1 signaling R-HSA-9020702 8.658458e-02 1.063 0 0
Gene expression (Transcription) R-HSA-74160 8.032264e-02 1.095 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.964242e-02 1.047 0 0
Interleukin-17 signaling R-HSA-448424 7.884105e-02 1.103 0 0
Macroautophagy R-HSA-1632852 7.463257e-02 1.127 0 0
Selective autophagy R-HSA-9663891 9.149230e-02 1.039 0 0
Cardiac conduction R-HSA-5576891 9.194262e-02 1.036 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.878749e-02 1.104 0 0
Ion channel transport R-HSA-983712 7.172140e-02 1.144 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.232311e-02 1.141 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.232311e-02 1.141 0 0
MECP2 regulates transcription factors R-HSA-9022707 8.140982e-02 1.089 0 0
Adrenoceptors R-HSA-390696 9.559591e-02 1.020 0 0
Rab regulation of trafficking R-HSA-9007101 9.499384e-02 1.022 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.884105e-02 1.103 0 0
FLT3 Signaling R-HSA-9607240 7.878749e-02 1.104 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.367854e-02 1.077 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.161298e-02 1.088 0 0
Signaling by FGFR4 R-HSA-5654743 9.563424e-02 1.019 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.598548e-02 1.018 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.598548e-02 1.018 0 0
Platelet sensitization by LDL R-HSA-432142 9.598548e-02 1.018 0 0
G2/M DNA damage checkpoint R-HSA-69473 9.606416e-02 1.017 0 0
Mitotic Anaphase R-HSA-68882 9.694071e-02 1.013 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.850636e-02 1.007 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.955951e-02 1.002 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.978596e-02 1.001 0 0
G1 Phase R-HSA-69236 1.016256e-01 0.993 0 0
Cyclin D associated events in G1 R-HSA-69231 1.016256e-01 0.993 0 0
Membrane Trafficking R-HSA-199991 1.036302e-01 0.985 0 0
ESR-mediated signaling R-HSA-8939211 1.049102e-01 0.979 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.317096e-01 0.880 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 1.317096e-01 0.880 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.317096e-01 0.880 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.317096e-01 0.880 0 0
TRAF3 deficiency - HSE R-HSA-5602571 1.317096e-01 0.880 0 0
XAV939 stabilizes AXIN R-HSA-5545619 1.317096e-01 0.880 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 1.317096e-01 0.880 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.317096e-01 0.880 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.317096e-01 0.880 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.317096e-01 0.880 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.317096e-01 0.880 0 0
ARMS-mediated activation R-HSA-170984 1.104205e-01 0.957 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.104205e-01 0.957 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.104205e-01 0.957 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.257950e-01 0.900 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.257950e-01 0.900 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.416378e-01 0.849 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.416378e-01 0.849 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.416378e-01 0.849 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.578733e-01 0.802 0 0
ERKs are inactivated R-HSA-202670 1.578733e-01 0.802 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 1.255921e-01 0.901 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.255921e-01 0.901 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.361105e-01 0.866 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.361105e-01 0.866 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.142973e-01 0.942 0 0
Striated Muscle Contraction R-HSA-390522 1.221496e-01 0.913 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.221496e-01 0.913 0 0
Voltage gated Potassium channels R-HSA-1296072 1.557040e-01 0.808 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.557851e-01 0.807 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.361641e-01 0.866 0 0
PKR-mediated signaling R-HSA-9833482 1.254576e-01 0.902 0 0
Signaling by FGFR2 R-HSA-5654738 1.254576e-01 0.902 0 0
Signaling by FGFR R-HSA-190236 1.466925e-01 0.834 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.141523e-01 0.943 0 0
Signaling by FGFR3 R-HSA-5654741 1.077996e-01 0.967 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.104205e-01 0.957 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.302254e-01 0.885 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.173532e-01 0.931 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.257950e-01 0.900 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.578733e-01 0.802 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.142973e-01 0.942 0 0
PI3K/AKT activation R-HSA-198203 1.257950e-01 0.900 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.361105e-01 0.866 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 1.470119e-01 0.833 0 0
DNA Double Strand Break Response R-HSA-5693606 1.459703e-01 0.836 0 0
ERK/MAPK targets R-HSA-198753 1.255921e-01 0.901 0 0
RNA Polymerase I Transcription R-HSA-73864 1.151973e-01 0.939 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.077996e-01 0.967 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.053959e-01 0.977 0 0
Josephin domain DUBs R-HSA-5689877 1.257950e-01 0.900 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.055084e-01 0.977 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.221496e-01 0.913 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.095977e-01 0.960 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.075737e-01 0.968 0 0
G alpha (q) signalling events R-HSA-416476 1.289532e-01 0.890 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.317096e-01 0.880 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.257950e-01 0.900 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.416378e-01 0.849 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.578733e-01 0.802 0 0
Meiotic recombination R-HSA-912446 1.484512e-01 0.828 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.470119e-01 0.833 0 0
Formation of definitive endoderm R-HSA-9823730 1.153843e-01 0.938 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 1.302254e-01 0.885 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.217926e-01 0.914 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.361641e-01 0.866 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.160811e-01 0.935 0 0
Autophagy R-HSA-9612973 1.249851e-01 0.903 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.104205e-01 0.957 0 0
Signaling by WNT R-HSA-195721 1.208292e-01 0.918 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.178844e-01 0.929 0 0
Signaling by PTK6 R-HSA-8848021 1.217926e-01 0.914 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.217926e-01 0.914 0 0
Integration of provirus R-HSA-162592 1.578733e-01 0.802 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.142973e-01 0.942 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.124479e-01 0.949 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.104205e-01 0.957 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.257950e-01 0.900 0 0
Rap1 signalling R-HSA-392517 1.055084e-01 0.977 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.267540e-01 0.897 0 0
NTRK3 as a dependence receptor R-HSA-9603505 1.317096e-01 0.880 0 0
Activation of RAC1 R-HSA-428540 1.578733e-01 0.802 0 0
Reproduction R-HSA-1474165 1.558670e-01 0.807 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 1.416378e-01 0.849 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.578733e-01 0.802 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.221821e-01 0.913 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.104205e-01 0.957 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.055084e-01 0.977 0 0
Signaling by Leptin R-HSA-2586552 1.257950e-01 0.900 0 0
IRE1alpha activates chaperones R-HSA-381070 1.083326e-01 0.965 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.579933e-01 0.801 0 0
Smooth Muscle Contraction R-HSA-445355 1.632652e-01 0.787 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.645826e-01 0.784 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.654197e-01 0.781 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.654197e-01 0.781 0 0
Signaling by ROBO receptors R-HSA-376176 1.690427e-01 0.772 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.693150e-01 0.771 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.693150e-01 0.771 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.716432e-01 0.765 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.716432e-01 0.765 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.716432e-01 0.765 0 0
Signalling to ERK5 R-HSA-198765 1.716432e-01 0.765 1 1
Interaction between PHLDA1 and AURKA R-HSA-8854521 1.716432e-01 0.765 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.716432e-01 0.765 0 0
Potassium transport channels R-HSA-1296067 1.716432e-01 0.765 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.716432e-01 0.765 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.716432e-01 0.765 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.716432e-01 0.765 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.716432e-01 0.765 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.716432e-01 0.765 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.716432e-01 0.765 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.716432e-01 0.765 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 1.716432e-01 0.765 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.716432e-01 0.765 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.716432e-01 0.765 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.716432e-01 0.765 0 0
C6 deamination of adenosine R-HSA-75102 1.716432e-01 0.765 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.736380e-01 0.760 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.736380e-01 0.760 0 0
MET activates RAS signaling R-HSA-8851805 1.744321e-01 0.758 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.744321e-01 0.758 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.744321e-01 0.758 0 0
Repression of WNT target genes R-HSA-4641265 1.744321e-01 0.758 0 0
MET interacts with TNS proteins R-HSA-8875513 2.097425e-01 0.678 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.097425e-01 0.678 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.097425e-01 0.678 0 0
MET activates PTPN11 R-HSA-8865999 2.097425e-01 0.678 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.097425e-01 0.678 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.460917e-01 0.609 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 2.460917e-01 0.609 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.460917e-01 0.609 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.460917e-01 0.609 0 0
Nucleotide catabolism defects R-HSA-9735786 2.460917e-01 0.609 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.460917e-01 0.609 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 2.460917e-01 0.609 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.460917e-01 0.609 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.807710e-01 0.552 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.807710e-01 0.552 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.807710e-01 0.552 0 0
Plus-strand DNA synthesis R-HSA-164525 3.138571e-01 0.503 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.138571e-01 0.503 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.138571e-01 0.503 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.138571e-01 0.503 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.138571e-01 0.503 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.138571e-01 0.503 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.912502e-01 0.718 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.912502e-01 0.718 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.912502e-01 0.718 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.082690e-01 0.681 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.082690e-01 0.681 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.454231e-01 0.462 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.454231e-01 0.462 0 0
Uncoating of the HIV Virion R-HSA-162585 3.454231e-01 0.462 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.254344e-01 0.647 0 0
Erythropoietin activates RAS R-HSA-9027284 2.254344e-01 0.647 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.254344e-01 0.647 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.254344e-01 0.647 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.426972e-01 0.615 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.600120e-01 0.585 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.045487e-01 0.689 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 2.045487e-01 0.689 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.773377e-01 0.557 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.166478e-01 0.664 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.288910e-01 0.640 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.288910e-01 0.640 0 0
DNA methylation R-HSA-5334118 2.288910e-01 0.640 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.288910e-01 0.640 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.828603e-01 0.738 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.118749e-01 0.506 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.114285e-01 0.675 0 0
Negative regulation of MET activity R-HSA-6807004 3.290213e-01 0.483 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.290213e-01 0.483 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.290213e-01 0.483 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.290213e-01 0.483 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.290213e-01 0.483 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.290213e-01 0.483 0 0
HDACs deacetylate histones R-HSA-3214815 1.786419e-01 0.748 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.662973e-01 0.575 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.865272e-01 0.729 0 0
Nucleosome assembly R-HSA-774815 2.411378e-01 0.618 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.411378e-01 0.618 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.858980e-01 0.731 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.192450e-01 0.659 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.043469e-01 0.517 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.298536e-01 0.482 0 0
mRNA 3'-end processing R-HSA-72187 3.134041e-01 0.504 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.239264e-01 0.490 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.239264e-01 0.490 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.071526e-01 0.513 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.721074e-01 0.565 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.372489e-01 0.472 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.170964e-01 0.499 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.288910e-01 0.640 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.412593e-01 0.618 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.460480e-01 0.461 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.460480e-01 0.461 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.170964e-01 0.499 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.721074e-01 0.565 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.773377e-01 0.557 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.773377e-01 0.557 0 0
DAP12 signaling R-HSA-2424491 2.412593e-01 0.618 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.220421e-01 0.654 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.789316e-01 0.555 0 0
EGFR downregulation R-HSA-182971 2.537341e-01 0.596 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.054791e-01 0.515 0 0
Signaling by EGFR R-HSA-177929 1.865272e-01 0.729 0 0
Developmental Cell Lineages R-HSA-9734767 2.641115e-01 0.578 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.427283e-01 0.615 0 0
Chromosome Maintenance R-HSA-73886 3.057337e-01 0.515 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.290213e-01 0.483 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.290213e-01 0.483 0 0
HATs acetylate histones R-HSA-3214847 2.638406e-01 0.579 0 0
Recycling pathway of L1 R-HSA-437239 2.614450e-01 0.583 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.426045e-01 0.465 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.043469e-01 0.517 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.460480e-01 0.461 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 2.000730e-01 0.699 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.958572e-01 0.708 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.254344e-01 0.647 0 0
Trafficking of AMPA receptors R-HSA-399719 2.537341e-01 0.596 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.922395e-01 0.716 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.849654e-01 0.733 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.849654e-01 0.733 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.447616e-01 0.611 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.879894e-01 0.726 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.789635e-01 0.747 0 0
Neurexins and neuroligins R-HSA-6794361 3.134041e-01 0.504 0 0
RMTs methylate histone arginines R-HSA-3214858 2.311246e-01 0.636 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.906665e-01 0.720 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.138571e-01 0.503 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.912502e-01 0.718 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.946367e-01 0.531 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.460480e-01 0.461 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.085752e-01 0.681 0 0
Prolonged ERK activation events R-HSA-169893 2.426972e-01 0.615 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.912502e-01 0.718 0 0
Regulation of CDH1 Function R-HSA-9764561 1.945361e-01 0.711 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.927533e-01 0.715 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.460917e-01 0.609 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.460917e-01 0.609 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.138571e-01 0.503 0 0
MET Receptor Activation R-HSA-6806942 3.454231e-01 0.462 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 2.254344e-01 0.647 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.426972e-01 0.615 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.426045e-01 0.465 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.290696e-01 0.483 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.123371e-01 0.673 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.946367e-01 0.531 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.412593e-01 0.618 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.916202e-01 0.535 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.041599e-01 0.690 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.820620e-01 0.550 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.820620e-01 0.550 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.760265e-01 0.559 0 0
MET activates STAT3 R-HSA-8875791 2.097425e-01 0.678 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.097425e-01 0.678 0 0
Dopamine receptors R-HSA-390651 2.460917e-01 0.609 0 0
Ceramide signalling R-HSA-193681 3.138571e-01 0.503 0 0
NADPH regeneration R-HSA-389542 3.454231e-01 0.462 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 3.454231e-01 0.462 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.254344e-01 0.647 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.045487e-01 0.689 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.043469e-01 0.517 0 0
Separation of Sister Chromatids R-HSA-2467813 2.431754e-01 0.614 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.946367e-01 0.531 0 0
ER-Phagosome pathway R-HSA-1236974 1.831377e-01 0.737 0 0
Platelet degranulation R-HSA-114608 2.300408e-01 0.638 0 0
Vesicle-mediated transport R-HSA-5653656 3.344751e-01 0.476 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.000730e-01 0.699 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.808620e-01 0.743 0 0
Cellular response to chemical stress R-HSA-9711123 2.052183e-01 0.688 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.460917e-01 0.609 0 0
Muscarinic acetylcholine receptors R-HSA-390648 2.807710e-01 0.552 0 0
GPER1 signaling R-HSA-9634597 2.717196e-01 0.566 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.170964e-01 0.499 0 0
Degradation of CDH1 R-HSA-9766229 2.820620e-01 0.550 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.253938e-01 0.488 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.371119e-01 0.625 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.239264e-01 0.490 0 0
G alpha (z) signalling events R-HSA-418597 3.450314e-01 0.462 0 0
TGFBR3 expression R-HSA-9839394 1.808620e-01 0.743 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.371119e-01 0.625 0 0
Hedgehog 'on' state R-HSA-5632684 3.162566e-01 0.500 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.311246e-01 0.636 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.097425e-01 0.678 0 0
Intracellular oxygen transport R-HSA-8981607 2.097425e-01 0.678 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.097425e-01 0.678 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.460917e-01 0.609 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.138571e-01 0.503 0 0
Abacavir transmembrane transport R-HSA-2161517 3.454231e-01 0.462 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.789316e-01 0.555 0 0
TCR signaling R-HSA-202403 3.523020e-01 0.453 0 0
Activation of BH3-only proteins R-HSA-114452 2.412593e-01 0.618 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.374073e-01 0.625 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.921982e-01 0.534 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.792511e-01 0.747 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.170964e-01 0.499 0 0
The NLRP3 inflammasome R-HSA-844456 3.118749e-01 0.506 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.231428e-01 0.491 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.946367e-01 0.531 0 0
Diseases of DNA repair R-HSA-9675135 2.512479e-01 0.600 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.411378e-01 0.618 0 0
Mitophagy R-HSA-5205647 3.043469e-01 0.517 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.097425e-01 0.678 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.460917e-01 0.609 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.807710e-01 0.552 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.138571e-01 0.503 0 0
Regulation of KIT signaling R-HSA-1433559 2.082690e-01 0.681 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.045487e-01 0.689 0 0
Signaling by NODAL R-HSA-1181150 3.290213e-01 0.483 0 0
Stimuli-sensing channels R-HSA-2672351 2.085752e-01 0.681 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.460128e-01 0.609 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.460480e-01 0.461 0 0
Hemostasis R-HSA-109582 2.181781e-01 0.661 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.537341e-01 0.596 0 0
Nephrin family interactions R-HSA-373753 3.290213e-01 0.483 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.253938e-01 0.488 0 0
Platelet homeostasis R-HSA-418346 3.222864e-01 0.492 0 0
RUNX2 regulates bone development R-HSA-8941326 3.298536e-01 0.482 0 0
Glycolysis R-HSA-70171 2.709903e-01 0.567 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.162566e-01 0.500 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.789316e-01 0.555 0 0
Co-stimulation by CD28 R-HSA-389356 2.717196e-01 0.566 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.807710e-01 0.552 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.138571e-01 0.503 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.138571e-01 0.503 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.138571e-01 0.503 0 0
VLDL assembly R-HSA-8866423 3.454231e-01 0.462 0 0
Nef and signal transduction R-HSA-164944 3.454231e-01 0.462 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.254344e-01 0.647 0 0
Synthesis of PG R-HSA-1483148 2.600120e-01 0.585 0 0
Protein hydroxylation R-HSA-9629569 3.290213e-01 0.483 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.789316e-01 0.555 0 0
Heme signaling R-HSA-9707616 2.362256e-01 0.627 0 0
Amine ligand-binding receptors R-HSA-375280 2.311246e-01 0.636 0 0
Signal transduction by L1 R-HSA-445144 3.290213e-01 0.483 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.789316e-01 0.555 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.170964e-01 0.499 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.789635e-01 0.747 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.143647e-01 0.669 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.912502e-01 0.718 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.138571e-01 0.503 0 0
Neurofascin interactions R-HSA-447043 3.454231e-01 0.462 0 0
TRP channels R-HSA-3295583 1.926134e-01 0.715 0 0
Tie2 Signaling R-HSA-210993 2.946367e-01 0.531 0 0
Maturation of nucleoprotein R-HSA-9694631 3.118749e-01 0.506 0 0
TBC/RABGAPs R-HSA-8854214 2.212182e-01 0.655 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.713347e-01 0.566 0 0
Calmodulin induced events R-HSA-111933 3.298536e-01 0.482 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.600120e-01 0.585 0 0
CaM pathway R-HSA-111997 3.298536e-01 0.482 0 0
Other interleukin signaling R-HSA-449836 3.118749e-01 0.506 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.043469e-01 0.517 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.912502e-01 0.718 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 3.491169e-01 0.457 0 0
Interferon alpha/beta signaling R-HSA-909733 2.655092e-01 0.576 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.529481e-01 0.452 0 0
Interferon Signaling R-HSA-913531 3.532111e-01 0.452 0 0
G2/M Checkpoints R-HSA-69481 3.541398e-01 0.451 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.549273e-01 0.450 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.553357e-01 0.449 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.553357e-01 0.449 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.629296e-01 0.440 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.629296e-01 0.440 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.629296e-01 0.440 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.656471e-01 0.437 0 0
mRNA Splicing R-HSA-72172 3.661051e-01 0.436 0 0
Stabilization of p53 R-HSA-69541 3.680341e-01 0.434 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.680341e-01 0.434 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.680341e-01 0.434 0 0
Signaling by ALK R-HSA-201556 3.680341e-01 0.434 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.682051e-01 0.434 0 0
Translation of Structural Proteins R-HSA-9694635 3.713816e-01 0.430 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.755387e-01 0.425 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.755387e-01 0.425 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.755387e-01 0.425 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.755387e-01 0.425 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.755387e-01 0.425 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.755387e-01 0.425 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.755387e-01 0.425 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.755387e-01 0.425 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.755387e-01 0.425 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.755387e-01 0.425 0 0
LDL remodeling R-HSA-8964041 3.755387e-01 0.425 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.755387e-01 0.425 0 0
Regulation of PTEN localization R-HSA-8948747 3.755387e-01 0.425 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.755387e-01 0.425 0 0
FGFR2 alternative splicing R-HSA-6803529 3.796437e-01 0.421 0 0
Notch-HLH transcription pathway R-HSA-350054 3.796437e-01 0.421 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.796437e-01 0.421 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.796437e-01 0.421 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.796437e-01 0.421 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.796437e-01 0.421 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.806877e-01 0.419 0 0
Interleukin-2 family signaling R-HSA-451927 3.806877e-01 0.419 0 0
S Phase R-HSA-69242 3.813653e-01 0.419 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.825823e-01 0.417 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.872579e-01 0.412 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.904998e-01 0.408 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.932850e-01 0.405 0 0
Maturation of spike protein R-HSA-9694548 3.932850e-01 0.405 0 0
Potential therapeutics for SARS R-HSA-9679191 3.945571e-01 0.404 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.961698e-01 0.402 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.961698e-01 0.402 0 0
Growth hormone receptor signaling R-HSA-982772 3.961698e-01 0.402 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.962933e-01 0.402 0 0
Reverse Transcription of HIV RNA R-HSA-162589 4.042705e-01 0.393 0 0
Minus-strand DNA synthesis R-HSA-164516 4.042705e-01 0.393 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.042705e-01 0.393 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.042705e-01 0.393 0 0
MET receptor recycling R-HSA-8875656 4.042705e-01 0.393 0 0
Formation of annular gap junctions R-HSA-196025 4.042705e-01 0.393 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.042705e-01 0.393 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.042705e-01 0.393 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.042705e-01 0.393 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.042705e-01 0.393 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.042705e-01 0.393 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.042705e-01 0.393 0 0
Sodium/Proton exchangers R-HSA-425986 4.042705e-01 0.393 0 0
Interleukin-23 signaling R-HSA-9020933 4.042705e-01 0.393 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.051253e-01 0.392 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.058149e-01 0.392 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.058149e-01 0.392 0 0
Intra-Golgi traffic R-HSA-6811438 4.058149e-01 0.392 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.082591e-01 0.389 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.082591e-01 0.389 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.124899e-01 0.385 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.124899e-01 0.385 0 0
Mitotic Prometaphase R-HSA-68877 4.143462e-01 0.383 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.182673e-01 0.379 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.182673e-01 0.379 0 0
Ca-dependent events R-HSA-111996 4.182673e-01 0.379 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.187073e-01 0.378 0 0
Glucose metabolism R-HSA-70326 4.205175e-01 0.376 0 0
Mitochondrial biogenesis R-HSA-1592230 4.205175e-01 0.376 0 0
ABC-family proteins mediated transport R-HSA-382556 4.235880e-01 0.373 0 0
Homology Directed Repair R-HSA-5693538 4.280878e-01 0.368 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.285881e-01 0.368 0 0
Long-term potentiation R-HSA-9620244 4.285881e-01 0.368 0 0
Formation of the nephric duct R-HSA-9830364 4.285881e-01 0.368 0 0
Signaling by SCF-KIT R-HSA-1433557 4.306324e-01 0.366 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.306324e-01 0.366 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.316821e-01 0.365 0 0
Lipophagy R-HSA-9613354 4.316821e-01 0.365 0 0
Gap junction degradation R-HSA-190873 4.316821e-01 0.365 0 0
ALK mutants bind TKIs R-HSA-9700645 4.316821e-01 0.365 0 0
mRNA Editing R-HSA-75072 4.316821e-01 0.365 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.316821e-01 0.365 0 0
Calcineurin activates NFAT R-HSA-2025928 4.316821e-01 0.365 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.316821e-01 0.365 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.316821e-01 0.365 0 0
WNT mediated activation of DVL R-HSA-201688 4.316821e-01 0.365 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.316821e-01 0.365 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.316821e-01 0.365 0 0
Interleukin-1 processing R-HSA-448706 4.316821e-01 0.365 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.316821e-01 0.365 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.316821e-01 0.365 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.318278e-01 0.365 0 0
HCMV Early Events R-HSA-9609690 4.321289e-01 0.364 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.356461e-01 0.361 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.375324e-01 0.359 0 0
Insulin receptor signalling cascade R-HSA-74751 4.394672e-01 0.357 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.400480e-01 0.356 0 0
DAP12 interactions R-HSA-2172127 4.429013e-01 0.354 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.444502e-01 0.352 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.444502e-01 0.352 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.444502e-01 0.352 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.444502e-01 0.352 0 0
Metalloprotease DUBs R-HSA-5689901 4.444502e-01 0.352 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.444502e-01 0.352 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.447449e-01 0.352 0 0
Signaling by Hedgehog R-HSA-5358351 4.455356e-01 0.351 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.550655e-01 0.342 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.550655e-01 0.342 0 0
DAG and IP3 signaling R-HSA-1489509 4.550655e-01 0.342 0 0
Co-inhibition by PD-1 R-HSA-389948 4.557914e-01 0.341 0 0
Binding and entry of HIV virion R-HSA-173107 4.578339e-01 0.339 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.578339e-01 0.339 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.578339e-01 0.339 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.578339e-01 0.339 0 0
2-LTR circle formation R-HSA-164843 4.578339e-01 0.339 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.578339e-01 0.339 0 0
Formation of apoptosome R-HSA-111458 4.578339e-01 0.339 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.578339e-01 0.339 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.578339e-01 0.339 0 0
Maturation of spike protein R-HSA-9683686 4.578339e-01 0.339 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 4.578339e-01 0.339 0 0
SARS-CoV Infections R-HSA-9679506 4.578915e-01 0.339 0 0
Leishmania phagocytosis R-HSA-9664417 4.595188e-01 0.338 0 0
Parasite infection R-HSA-9664407 4.595188e-01 0.338 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.595188e-01 0.338 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.600639e-01 0.337 0 0
Packaging Of Telomere Ends R-HSA-171306 4.600639e-01 0.337 0 0
Triglyceride biosynthesis R-HSA-75109 4.600639e-01 0.337 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.600639e-01 0.337 0 0
Insulin processing R-HSA-264876 4.600639e-01 0.337 0 0
MHC class II antigen presentation R-HSA-2132295 4.657102e-01 0.332 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.671170e-01 0.331 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.671170e-01 0.331 0 0
Formation of the cornified envelope R-HSA-6809371 4.731717e-01 0.325 0 0
Host Interactions of HIV factors R-HSA-162909 4.731717e-01 0.325 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.754184e-01 0.323 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.754184e-01 0.323 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.754184e-01 0.323 0 0
Inflammasomes R-HSA-622312 4.754184e-01 0.323 0 0
Adaptive Immune System R-HSA-1280218 4.756205e-01 0.323 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.790486e-01 0.320 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.827838e-01 0.316 0 0
FGFR2b ligand binding and activation R-HSA-190377 4.827838e-01 0.316 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 4.827838e-01 0.316 0 0
Chylomicron assembly R-HSA-8963888 4.827838e-01 0.316 0 0
Bicarbonate transporters R-HSA-425381 4.827838e-01 0.316 0 0
Suppression of apoptosis R-HSA-9635465 4.827838e-01 0.316 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.872651e-01 0.312 0 0
G1/S Transition R-HSA-69206 4.880127e-01 0.312 0 0
Gene Silencing by RNA R-HSA-211000 4.887831e-01 0.311 0 0
Signaling by Erythropoietin R-HSA-9006335 4.905047e-01 0.309 0 0
Late endosomal microautophagy R-HSA-9615710 4.905047e-01 0.309 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.905047e-01 0.309 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.905047e-01 0.309 0 0
DARPP-32 events R-HSA-180024 4.905047e-01 0.309 0 0
NGF-stimulated transcription R-HSA-9031628 4.908534e-01 0.309 0 0
G2/M Transition R-HSA-69275 4.980950e-01 0.303 0 0
Downstream TCR signaling R-HSA-202424 4.983744e-01 0.302 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.053147e-01 0.296 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.053147e-01 0.296 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.065870e-01 0.295 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.065870e-01 0.295 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.065870e-01 0.295 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.065870e-01 0.295 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.065870e-01 0.295 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.065870e-01 0.295 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.065870e-01 0.295 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.065870e-01 0.295 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.071284e-01 0.295 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.101075e-01 0.292 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.101075e-01 0.292 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.101075e-01 0.292 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.102642e-01 0.292 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.140582e-01 0.289 0 0
PI3K Cascade R-HSA-109704 5.140582e-01 0.289 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.198422e-01 0.284 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.198422e-01 0.284 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.198422e-01 0.284 0 0
Cargo concentration in the ER R-HSA-5694530 5.198422e-01 0.284 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.198422e-01 0.284 0 0
Downstream signal transduction R-HSA-186763 5.198422e-01 0.284 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.198422e-01 0.284 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.254471e-01 0.279 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.254471e-01 0.279 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.292961e-01 0.276 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.292961e-01 0.276 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.292961e-01 0.276 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.292961e-01 0.276 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.292961e-01 0.276 0 0
Interleukin-15 signaling R-HSA-8983432 5.292961e-01 0.276 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.292961e-01 0.276 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.292961e-01 0.276 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.292961e-01 0.276 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.292961e-01 0.276 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.292961e-01 0.276 0 0
Deubiquitination R-HSA-5688426 5.317124e-01 0.274 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 5.330094e-01 0.273 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.330094e-01 0.273 0 0
G0 and Early G1 R-HSA-1538133 5.340816e-01 0.272 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.340816e-01 0.272 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.340816e-01 0.272 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.360759e-01 0.271 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.366872e-01 0.270 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.366872e-01 0.270 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.366872e-01 0.270 0 0
Circadian clock R-HSA-9909396 5.459767e-01 0.263 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.477741e-01 0.261 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.480287e-01 0.261 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.480287e-01 0.261 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.480287e-01 0.261 0 0
Cardiogenesis R-HSA-9733709 5.480287e-01 0.261 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.480939e-01 0.261 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.509613e-01 0.259 0 0
FGFR2c ligand binding and activation R-HSA-190375 5.509613e-01 0.259 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.509613e-01 0.259 0 0
FGFR4 ligand binding and activation R-HSA-190322 5.509613e-01 0.259 0 0
Frs2-mediated activation R-HSA-170968 5.509613e-01 0.259 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.509613e-01 0.259 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 5.509613e-01 0.259 0 0
Mtb iron assimilation by chelation R-HSA-1222449 5.509613e-01 0.259 0 0
FGFR3 mutant receptor activation R-HSA-2033514 5.509613e-01 0.259 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.509613e-01 0.259 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.509613e-01 0.259 0 0
Maturation of nucleoprotein R-HSA-9683610 5.509613e-01 0.259 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.509613e-01 0.259 0 0
Signaling by NOTCH1 R-HSA-1980143 5.579938e-01 0.253 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.616804e-01 0.251 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.616804e-01 0.251 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.624933e-01 0.250 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.665249e-01 0.247 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.665249e-01 0.247 0 0
Potassium Channels R-HSA-1296071 5.665249e-01 0.247 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.694729e-01 0.245 0 0
Signaling by NOTCH3 R-HSA-9012852 5.694729e-01 0.245 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.716306e-01 0.243 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.716306e-01 0.243 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.716306e-01 0.243 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.716306e-01 0.243 0 0
FGFR3c ligand binding and activation R-HSA-190372 5.716306e-01 0.243 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.716306e-01 0.243 0 0
Physiological factors R-HSA-5578768 5.716306e-01 0.243 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.716306e-01 0.243 0 0
HDL assembly R-HSA-8963896 5.716306e-01 0.243 0 0
Zinc transporters R-HSA-435354 5.716306e-01 0.243 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.716306e-01 0.243 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.750341e-01 0.240 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.750341e-01 0.240 0 0
Nuclear import of Rev protein R-HSA-180746 5.750341e-01 0.240 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.750341e-01 0.240 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.764291e-01 0.239 0 0
TNF signaling R-HSA-75893 5.800782e-01 0.237 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 5.800782e-01 0.237 0 0
Extracellular matrix organization R-HSA-1474244 5.857060e-01 0.232 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.880885e-01 0.231 0 0
Regulation of Apoptosis R-HSA-169911 5.880885e-01 0.231 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.880885e-01 0.231 0 0
PERK regulates gene expression R-HSA-381042 5.880885e-01 0.231 0 0
IRS-mediated signalling R-HSA-112399 5.905171e-01 0.229 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.913497e-01 0.228 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.913497e-01 0.228 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.913497e-01 0.228 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 5.913497e-01 0.228 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.913497e-01 0.228 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.913497e-01 0.228 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.913497e-01 0.228 0 0
Translesion synthesis by REV1 R-HSA-110312 5.913497e-01 0.228 0 0
FGFR3 ligand binding and activation R-HSA-190239 5.913497e-01 0.228 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.913497e-01 0.228 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.913497e-01 0.228 0 0
Protein methylation R-HSA-8876725 5.913497e-01 0.228 0 0
Interferon gamma signaling R-HSA-877300 5.932912e-01 0.227 0 0
Signaling by MET R-HSA-6806834 5.944206e-01 0.226 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.944206e-01 0.226 0 0
Hedgehog 'off' state R-HSA-5610787 5.987677e-01 0.223 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.008428e-01 0.221 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 6.008428e-01 0.221 0 0
G1/S-Specific Transcription R-HSA-69205 6.008428e-01 0.221 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.032443e-01 0.220 0 0
Translesion synthesis by POLI R-HSA-5656121 6.101622e-01 0.215 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.101622e-01 0.215 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 6.101622e-01 0.215 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.101622e-01 0.215 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.101622e-01 0.215 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.101622e-01 0.215 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.101622e-01 0.215 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.101622e-01 0.215 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.101622e-01 0.215 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.101622e-01 0.215 0 0
Negative regulation of FLT3 R-HSA-9706369 6.101622e-01 0.215 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.101622e-01 0.215 0 0
Attachment and Entry R-HSA-9678110 6.101622e-01 0.215 0 0
Atorvastatin ADME R-HSA-9754706 6.101622e-01 0.215 0 0
Metabolism of non-coding RNA R-HSA-194441 6.108863e-01 0.214 0 0
snRNP Assembly R-HSA-191859 6.108863e-01 0.214 0 0
Regulation of beta-cell development R-HSA-186712 6.108863e-01 0.214 0 0
Triglyceride metabolism R-HSA-8979227 6.108863e-01 0.214 0 0
Degradation of AXIN R-HSA-4641257 6.132969e-01 0.212 0 0
Degradation of DVL R-HSA-4641258 6.132969e-01 0.212 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.132969e-01 0.212 0 0
Cleavage of the damaged purine R-HSA-110331 6.132969e-01 0.212 0 0
HIV Infection R-HSA-162906 6.138653e-01 0.212 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.143732e-01 0.212 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.208130e-01 0.207 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.208130e-01 0.207 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.208130e-01 0.207 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.208130e-01 0.207 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.208130e-01 0.207 0 0
Kinesins R-HSA-983189 6.208130e-01 0.207 0 0
MET promotes cell motility R-HSA-8875878 6.254515e-01 0.204 0 0
Depurination R-HSA-73927 6.254515e-01 0.204 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.254515e-01 0.204 0 0
Elastic fibre formation R-HSA-1566948 6.254515e-01 0.204 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.281098e-01 0.202 0 0
Translesion synthesis by POLK R-HSA-5655862 6.281098e-01 0.202 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.281098e-01 0.202 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.281098e-01 0.202 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.281098e-01 0.202 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 6.281098e-01 0.202 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.281098e-01 0.202 0 0
Heme assimilation R-HSA-9927020 6.281098e-01 0.202 0 0
Scavenging by Class B Receptors R-HSA-3000471 6.281098e-01 0.202 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.281098e-01 0.202 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.281098e-01 0.202 0 0
Disorders of Developmental Biology R-HSA-9675151 6.281098e-01 0.202 0 0
Galactose catabolism R-HSA-70370 6.281098e-01 0.202 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.296181e-01 0.201 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.296181e-01 0.201 0 0
Opioid Signalling R-HSA-111885 6.296181e-01 0.201 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.296279e-01 0.201 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.305659e-01 0.200 0 0
PLC beta mediated events R-HSA-112043 6.305659e-01 0.200 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.373077e-01 0.196 0 0
RAS processing R-HSA-9648002 6.373077e-01 0.196 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.401437e-01 0.194 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.401437e-01 0.194 0 0
Signaling by PDGF R-HSA-186797 6.401437e-01 0.194 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.452321e-01 0.190 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.452321e-01 0.190 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.452321e-01 0.190 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.452321e-01 0.190 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.452321e-01 0.190 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.452321e-01 0.190 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.452321e-01 0.190 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.452321e-01 0.190 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.488672e-01 0.188 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.488672e-01 0.188 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.488672e-01 0.188 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.488672e-01 0.188 0 0
Generation of second messenger molecules R-HSA-202433 6.488672e-01 0.188 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.495459e-01 0.187 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.495459e-01 0.187 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.517874e-01 0.186 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.585075e-01 0.181 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 6.601323e-01 0.180 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.601323e-01 0.180 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.601323e-01 0.180 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.601323e-01 0.180 0 0
GAB1 signalosome R-HSA-180292 6.615671e-01 0.179 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.615671e-01 0.179 0 0
Activated point mutants of FGFR2 R-HSA-2033519 6.615671e-01 0.179 0 0
Mismatch Repair R-HSA-5358508 6.615671e-01 0.179 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.615671e-01 0.179 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.615671e-01 0.179 0 0
PKA activation in glucagon signalling R-HSA-164378 6.615671e-01 0.179 0 0
Polo-like kinase mediated events R-HSA-156711 6.615671e-01 0.179 0 0
PKA activation R-HSA-163615 6.615671e-01 0.179 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.615671e-01 0.179 0 0
Post NMDA receptor activation events R-HSA-438064 6.616458e-01 0.179 0 0
Cellular response to hypoxia R-HSA-1234174 6.678212e-01 0.175 0 0
HIV Transcription Initiation R-HSA-167161 6.711054e-01 0.173 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.711054e-01 0.173 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.711054e-01 0.173 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.711054e-01 0.173 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.711054e-01 0.173 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.711054e-01 0.173 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.711054e-01 0.173 0 0
Translation of Structural Proteins R-HSA-9683701 6.711054e-01 0.173 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.730958e-01 0.172 0 0
Disease R-HSA-1643685 6.745637e-01 0.171 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.771509e-01 0.169 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.771509e-01 0.169 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.771509e-01 0.169 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.771509e-01 0.169 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.771509e-01 0.169 0 0
Pyrimidine biosynthesis R-HSA-500753 6.771509e-01 0.169 0 0
Regulation of signaling by CBL R-HSA-912631 6.771509e-01 0.169 0 0
Specification of the neural plate border R-HSA-9834899 6.771509e-01 0.169 0 0
Translesion Synthesis by POLH R-HSA-110320 6.771509e-01 0.169 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.771509e-01 0.169 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.771509e-01 0.169 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.771509e-01 0.169 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.771509e-01 0.169 0 0
Signaling by NOTCH R-HSA-157118 6.791237e-01 0.168 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.817897e-01 0.166 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.817897e-01 0.166 0 0
Depyrimidination R-HSA-73928 6.817897e-01 0.166 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.853907e-01 0.164 0 0
G-protein mediated events R-HSA-112040 6.853907e-01 0.164 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 6.920180e-01 0.160 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.920180e-01 0.160 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.920180e-01 0.160 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.920180e-01 0.160 0 0
Glycogen synthesis R-HSA-3322077 6.920180e-01 0.160 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.921884e-01 0.160 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.921884e-01 0.160 0 0
FCERI mediated MAPK activation R-HSA-2871796 6.935247e-01 0.159 0 0
Transcription of the HIV genome R-HSA-167172 6.939113e-01 0.159 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.939113e-01 0.159 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.023051e-01 0.153 0 0
PPARA activates gene expression R-HSA-1989781 7.051940e-01 0.152 0 0
FGFR2 ligand binding and activation R-HSA-190241 7.062013e-01 0.151 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.062013e-01 0.151 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.062013e-01 0.151 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.062013e-01 0.151 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.062013e-01 0.151 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.062013e-01 0.151 0 0
Basigin interactions R-HSA-210991 7.062013e-01 0.151 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 7.062013e-01 0.151 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.062013e-01 0.151 0 0
Signaling by Insulin receptor R-HSA-74752 7.068412e-01 0.151 0 0
COPII-mediated vesicle transport R-HSA-204005 7.104273e-01 0.148 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.121439e-01 0.147 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.121439e-01 0.147 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.121439e-01 0.147 0 0
Somitogenesis R-HSA-9824272 7.121439e-01 0.147 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.121439e-01 0.147 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.161798e-01 0.145 0 0
HIV Life Cycle R-HSA-162587 7.161798e-01 0.145 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.197323e-01 0.143 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.197323e-01 0.143 0 0
Glutathione synthesis and recycling R-HSA-174403 7.197323e-01 0.143 0 0
Attachment and Entry R-HSA-9694614 7.197323e-01 0.143 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.197323e-01 0.143 0 0
Ribavirin ADME R-HSA-9755088 7.197323e-01 0.143 0 0
Assembly Of The HIV Virion R-HSA-175474 7.197323e-01 0.143 0 0
Cellular response to starvation R-HSA-9711097 7.215681e-01 0.142 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.217087e-01 0.142 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.217087e-01 0.142 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.217087e-01 0.142 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.217087e-01 0.142 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.217087e-01 0.142 0 0
HCMV Infection R-HSA-9609646 7.246330e-01 0.140 0 0
Integration of energy metabolism R-HSA-163685 7.256093e-01 0.139 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.310040e-01 0.136 0 0
Signaling by TGFB family members R-HSA-9006936 7.321350e-01 0.135 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.326409e-01 0.135 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.326409e-01 0.135 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.326409e-01 0.135 0 0
LDL clearance R-HSA-8964038 7.326409e-01 0.135 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.326409e-01 0.135 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.344412e-01 0.134 0 0
GPCR downstream signalling R-HSA-388396 7.399560e-01 0.131 0 0
Intraflagellar transport R-HSA-5620924 7.400343e-01 0.131 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.400343e-01 0.131 0 0
Metal ion SLC transporters R-HSA-425410 7.400343e-01 0.131 0 0
Gluconeogenesis R-HSA-70263 7.400343e-01 0.131 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.413867e-01 0.130 0 0
Signaling by NOTCH4 R-HSA-9013694 7.413867e-01 0.130 0 0
Signaling by ERBB4 R-HSA-1236394 7.413867e-01 0.130 0 0
Biosynthesis of maresins R-HSA-9018682 7.449557e-01 0.128 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.449557e-01 0.128 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.449557e-01 0.128 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.449557e-01 0.128 0 0
Telomere Maintenance R-HSA-157579 7.474883e-01 0.126 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 7.487023e-01 0.126 0 0
Protein ubiquitination R-HSA-8852135 7.487023e-01 0.126 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.488042e-01 0.126 0 0
DNA Damage Bypass R-HSA-73893 7.488042e-01 0.126 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.488042e-01 0.126 0 0
Leishmania infection R-HSA-9658195 7.563617e-01 0.121 0 0
Parasitic Infection Pathways R-HSA-9824443 7.563617e-01 0.121 0 0
CYP2E1 reactions R-HSA-211999 7.567040e-01 0.121 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.567040e-01 0.121 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.567040e-01 0.121 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.567040e-01 0.121 0 0
Azathioprine ADME R-HSA-9748787 7.573186e-01 0.121 0 0
Cellular response to heat stress R-HSA-3371556 7.607960e-01 0.119 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.633599e-01 0.117 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.633599e-01 0.117 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.655824e-01 0.116 0 0
HSF1-dependent transactivation R-HSA-3371571 7.655824e-01 0.116 0 0
The phototransduction cascade R-HSA-2514856 7.655824e-01 0.116 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.679118e-01 0.115 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.679118e-01 0.115 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.679118e-01 0.115 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.679118e-01 0.115 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.679118e-01 0.115 0 0
Laminin interactions R-HSA-3000157 7.679118e-01 0.115 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.679118e-01 0.115 0 0
PCP/CE pathway R-HSA-4086400 7.696569e-01 0.114 0 0
Integrin cell surface interactions R-HSA-216083 7.696569e-01 0.114 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.734113e-01 0.112 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.736007e-01 0.111 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.763172e-01 0.110 0 0
Signaling by GPCR R-HSA-372790 7.772923e-01 0.109 0 0
MET activates PTK2 signaling R-HSA-8874081 7.786039e-01 0.109 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.786039e-01 0.109 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.786039e-01 0.109 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.786039e-01 0.109 0 0
Abacavir ADME R-HSA-2161522 7.786039e-01 0.109 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.786039e-01 0.109 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.786039e-01 0.109 0 0
Viral Infection Pathways R-HSA-9824446 7.805580e-01 0.108 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.813784e-01 0.107 0 0
Nucleotide biosynthesis R-HSA-8956320 7.813784e-01 0.107 0 0
DNA Repair R-HSA-73894 7.875685e-01 0.104 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.888041e-01 0.103 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.888041e-01 0.103 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.888041e-01 0.103 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.888041e-01 0.103 0 0
Cristae formation R-HSA-8949613 7.888041e-01 0.103 0 0
Signaling by BMP R-HSA-201451 7.888041e-01 0.103 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.888041e-01 0.103 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.888041e-01 0.103 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.888041e-01 0.103 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.889207e-01 0.103 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.896213e-01 0.103 0 0
Paracetamol ADME R-HSA-9753281 7.962328e-01 0.099 0 0
Gastrulation R-HSA-9758941 7.971355e-01 0.098 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.985349e-01 0.098 0 0
HIV elongation arrest and recovery R-HSA-167287 7.985349e-01 0.098 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.985349e-01 0.098 0 0
Telomere Extension By Telomerase R-HSA-171319 7.985349e-01 0.098 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.985349e-01 0.098 0 0
Prednisone ADME R-HSA-9757110 7.985349e-01 0.098 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.013909e-01 0.096 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 8.072784e-01 0.093 0 0
Thyroxine biosynthesis R-HSA-209968 8.078179e-01 0.093 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 8.078179e-01 0.093 0 0
Synthesis of PA R-HSA-1483166 8.101871e-01 0.091 0 0
Protein localization R-HSA-9609507 8.147010e-01 0.089 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.166738e-01 0.088 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.166738e-01 0.088 0 0
Neurotransmitter clearance R-HSA-112311 8.166738e-01 0.088 0 0
Activation of the pre-replicative complex R-HSA-68962 8.166738e-01 0.088 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.166738e-01 0.088 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.168398e-01 0.088 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.186126e-01 0.087 0 0
Extension of Telomeres R-HSA-180786 8.232830e-01 0.084 0 0
Peroxisomal protein import R-HSA-9033241 8.232830e-01 0.084 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.232830e-01 0.084 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.251221e-01 0.083 0 0
Budding and maturation of HIV virion R-HSA-162588 8.251221e-01 0.083 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.251221e-01 0.083 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 8.251221e-01 0.083 0 0
Metabolism of RNA R-HSA-8953854 8.252863e-01 0.083 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.254534e-01 0.083 0 0
tRNA Aminoacylation R-HSA-379724 8.295219e-01 0.081 0 0
Neuronal System R-HSA-112316 8.301743e-01 0.081 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.331815e-01 0.079 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.331815e-01 0.079 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.346992e-01 0.078 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.346992e-01 0.078 0 0
Inositol phosphate metabolism R-HSA-1483249 8.346992e-01 0.078 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.355616e-01 0.078 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.355616e-01 0.078 0 0
Collagen degradation R-HSA-1442490 8.355616e-01 0.078 0 0
Defective B3GALTL causes PpS R-HSA-5083635 8.408700e-01 0.075 0 0
Nuclear RNA decay R-HSA-9930044 8.408700e-01 0.075 0 0
G-protein beta:gamma signalling R-HSA-397795 8.408700e-01 0.075 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.408700e-01 0.075 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.408700e-01 0.075 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.408700e-01 0.075 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.408700e-01 0.075 0 0
Mitochondrial protein import R-HSA-1268020 8.414074e-01 0.075 0 0
tRNA processing in the nucleus R-HSA-6784531 8.414074e-01 0.075 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.482046e-01 0.071 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.482046e-01 0.071 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.482046e-01 0.071 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.482046e-01 0.071 0 0
Heme degradation R-HSA-189483 8.482046e-01 0.071 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.498177e-01 0.071 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.534993e-01 0.069 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.539094e-01 0.069 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.545503e-01 0.068 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.552015e-01 0.068 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.552015e-01 0.068 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.552015e-01 0.068 0 0
Signal amplification R-HSA-392518 8.552015e-01 0.068 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.552015e-01 0.068 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.552015e-01 0.068 0 0
Hyaluronan metabolism R-HSA-2142845 8.552015e-01 0.068 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.552015e-01 0.068 0 0
Signaling by NOTCH2 R-HSA-1980145 8.552015e-01 0.068 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 8.561922e-01 0.067 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.584298e-01 0.066 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.618763e-01 0.065 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.629499e-01 0.064 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.629499e-01 0.064 0 0
Peptide hormone metabolism R-HSA-2980736 8.640997e-01 0.063 0 0
Collagen formation R-HSA-1474290 8.671042e-01 0.062 0 0
Kidney development R-HSA-9830369 8.678999e-01 0.062 0 0
GPVI-mediated activation cascade R-HSA-114604 8.682438e-01 0.061 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.682438e-01 0.061 0 0
FLT3 signaling in disease R-HSA-9682385 8.682438e-01 0.061 0 0
HSF1 activation R-HSA-3371511 8.682438e-01 0.061 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.682438e-01 0.061 0 0
Triglyceride catabolism R-HSA-163560 8.682438e-01 0.061 0 0
RNA Polymerase III Transcription R-HSA-74158 8.682438e-01 0.061 0 0
Post-translational protein modification R-HSA-597592 8.736326e-01 0.059 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 8.743182e-01 0.058 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.743182e-01 0.058 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.743182e-01 0.058 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.743182e-01 0.058 0 0
SLC-mediated transport of organic cations R-HSA-549127 8.743182e-01 0.058 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.743182e-01 0.058 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.753070e-01 0.058 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 8.788018e-01 0.056 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.793427e-01 0.056 0 0
Purine salvage R-HSA-74217 8.801128e-01 0.055 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.801128e-01 0.055 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.801128e-01 0.055 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.856406e-01 0.053 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.856406e-01 0.053 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.856406e-01 0.053 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.856406e-01 0.053 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.856406e-01 0.053 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.856406e-01 0.053 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.860994e-01 0.053 0 0
ECM proteoglycans R-HSA-3000178 8.860994e-01 0.053 0 0
Regulation of insulin secretion R-HSA-422356 8.867701e-01 0.052 0 0
Ub-specific processing proteases R-HSA-5689880 8.880284e-01 0.052 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.909139e-01 0.050 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.909139e-01 0.050 0 0
HIV Transcription Elongation R-HSA-167169 8.909139e-01 0.050 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 8.909139e-01 0.050 0 0
Attenuation phase R-HSA-3371568 8.909139e-01 0.050 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.909139e-01 0.050 0 0
Glycogen metabolism R-HSA-8982491 8.909139e-01 0.050 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.943020e-01 0.049 0 0
Ca2+ pathway R-HSA-4086398 8.943020e-01 0.049 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.949056e-01 0.048 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.959443e-01 0.048 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.959443e-01 0.048 0 0
ROS and RNS production in phagocytes R-HSA-1222556 8.981942e-01 0.047 0 0
PI Metabolism R-HSA-1483255 9.005871e-01 0.045 0 0
Signaling by FGFR1 in disease R-HSA-5655302 9.007430e-01 0.045 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.007430e-01 0.045 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.007430e-01 0.045 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.007430e-01 0.045 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.017061e-01 0.045 0 0
Influenza Infection R-HSA-168255 9.038164e-01 0.044 0 0
DNA Replication R-HSA-69306 9.043591e-01 0.044 0 0
Activation of GABAB receptors R-HSA-991365 9.053207e-01 0.043 0 0
GABA B receptor activation R-HSA-977444 9.053207e-01 0.043 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.053207e-01 0.043 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.053207e-01 0.043 0 0
UCH proteinases R-HSA-5689603 9.055811e-01 0.043 0 0
Keratinization R-HSA-6805567 9.068224e-01 0.042 0 0
RSV-host interactions R-HSA-9833110 9.099323e-01 0.041 0 0
ABC transporter disorders R-HSA-5619084 9.124646e-01 0.040 0 0
Cholesterol biosynthesis R-HSA-191273 9.124646e-01 0.040 0 0
Interleukin-10 signaling R-HSA-6783783 9.124646e-01 0.040 0 0
Proteasome assembly R-HSA-9907900 9.138533e-01 0.039 0 0
Gap junction trafficking R-HSA-190828 9.138533e-01 0.039 0 0
HCMV Late Events R-HSA-9610379 9.143568e-01 0.039 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.157273e-01 0.038 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.174491e-01 0.037 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.178271e-01 0.037 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.178271e-01 0.037 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.178271e-01 0.037 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.216178e-01 0.035 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.216178e-01 0.035 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.249203e-01 0.034 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.252338e-01 0.034 0 0
Synthesis of PC R-HSA-1483191 9.252338e-01 0.034 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.252338e-01 0.034 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.276691e-01 0.033 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.286833e-01 0.032 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.291029e-01 0.032 0 0
Transmission across Chemical Synapses R-HSA-112315 9.295551e-01 0.032 0 0
Gap junction trafficking and regulation R-HSA-157858 9.319738e-01 0.031 0 0
Ribosome-associated quality control R-HSA-9948299 9.333335e-01 0.030 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.351127e-01 0.029 0 0
SLC transporter disorders R-HSA-5619102 9.354327e-01 0.029 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.380004e-01 0.028 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.398486e-01 0.027 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.403556e-01 0.027 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.409631e-01 0.026 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.409631e-01 0.026 0 0
Orc1 removal from chromatin R-HSA-68949 9.409631e-01 0.026 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.418732e-01 0.026 0 0
Peptide chain elongation R-HSA-156902 9.426256e-01 0.026 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.436877e-01 0.025 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.436877e-01 0.025 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.462867e-01 0.024 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.469215e-01 0.024 0 0
Neurotransmitter release cycle R-HSA-112310 9.469215e-01 0.024 0 0
Base Excision Repair R-HSA-73884 9.469215e-01 0.024 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.487659e-01 0.023 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.489528e-01 0.023 0 0
Transport of small molecules R-HSA-382551 9.498440e-01 0.022 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.511308e-01 0.022 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.511308e-01 0.022 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.511308e-01 0.022 0 0
rRNA processing R-HSA-72312 9.517924e-01 0.021 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.527953e-01 0.021 0 0
Protein folding R-HSA-391251 9.527953e-01 0.021 0 0
Dectin-2 family R-HSA-5621480 9.533867e-01 0.021 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.555386e-01 0.020 0 0
Mitochondrial protein degradation R-HSA-9837999 9.563605e-01 0.019 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.580450e-01 0.019 0 0
GABA receptor activation R-HSA-977443 9.595493e-01 0.018 0 0
Glutathione conjugation R-HSA-156590 9.595493e-01 0.018 0 0
Metabolism of polyamines R-HSA-351202 9.595493e-01 0.018 0 0
Eukaryotic Translation Termination R-HSA-72764 9.596672e-01 0.018 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.612291e-01 0.017 0 0
Nucleotide salvage R-HSA-8956321 9.614170e-01 0.017 0 0
Aquaporin-mediated transport R-HSA-445717 9.614170e-01 0.017 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.622688e-01 0.017 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.631987e-01 0.016 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.631987e-01 0.016 0 0
Peptide ligand-binding receptors R-HSA-375276 9.642165e-01 0.016 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.648981e-01 0.016 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.648981e-01 0.016 0 0
G alpha (i) signalling events R-HSA-418594 9.652935e-01 0.015 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.655744e-01 0.015 0 0
Xenobiotics R-HSA-211981 9.665192e-01 0.015 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.677906e-01 0.014 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.680654e-01 0.014 0 0
Selenocysteine synthesis R-HSA-2408557 9.682069e-01 0.014 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.694494e-01 0.013 0 0
Viral mRNA Translation R-HSA-192823 9.706451e-01 0.013 0 0
Nicotinate metabolism R-HSA-196807 9.709473e-01 0.013 0 0
Selenoamino acid metabolism R-HSA-2408522 9.718841e-01 0.012 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.722894e-01 0.012 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.729873e-01 0.012 0 0
Infectious disease R-HSA-5663205 9.738356e-01 0.012 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.758722e-01 0.011 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.759552e-01 0.011 0 0
Metal ion assimilation from the host R-HSA-9638482 9.759552e-01 0.011 0 0
Metabolism of cofactors R-HSA-8978934 9.759552e-01 0.011 0 0
Metabolism of porphyrins R-HSA-189445 9.759552e-01 0.011 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.759774e-01 0.011 0 0
Synthesis of DNA R-HSA-69239 9.759774e-01 0.011 0 0
Purine catabolism R-HSA-74259 9.770662e-01 0.010 0 0
tRNA processing R-HSA-72306 9.777224e-01 0.010 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.781259e-01 0.010 0 0
Aspirin ADME R-HSA-9749641 9.781259e-01 0.010 0 0
G alpha (s) signalling events R-HSA-418555 9.784568e-01 0.009 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.787137e-01 0.009 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.788347e-01 0.009 0 0
Translation R-HSA-72766 9.788631e-01 0.009 0 0
Signaling by FGFR in disease R-HSA-1226099 9.791367e-01 0.009 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.798577e-01 0.009 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.798577e-01 0.009 0 0
Centrosome maturation R-HSA-380287 9.801008e-01 0.009 0 0
Phospholipid metabolism R-HSA-1483257 9.809905e-01 0.008 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.818977e-01 0.008 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.835325e-01 0.007 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.850198e-01 0.007 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.855775e-01 0.006 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.870030e-01 0.006 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.870338e-01 0.006 0 0
Drug ADME R-HSA-9748784 9.873094e-01 0.006 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.887240e-01 0.005 0 0
Cilium Assembly R-HSA-5617833 9.887399e-01 0.005 0 0
Pyruvate metabolism R-HSA-70268 9.892455e-01 0.005 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.897429e-01 0.004 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.897429e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.902033e-01 0.004 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.906699e-01 0.004 0 0
FCGR activation R-HSA-2029481 9.922803e-01 0.003 0 0
Scavenging of heme from plasma R-HSA-2168880 9.933032e-01 0.003 0 0
Metabolism of proteins R-HSA-392499 9.935743e-01 0.003 0 0
Mitochondrial translation elongation R-HSA-5389840 9.936131e-01 0.003 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.939087e-01 0.003 0 0
Mitochondrial translation initiation R-HSA-5368286 9.941907e-01 0.003 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.954165e-01 0.002 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.958311e-01 0.002 0 0
Neddylation R-HSA-8951664 9.963898e-01 0.002 0 0
Visual phototransduction R-HSA-2187338 9.964000e-01 0.002 0 0
Mitochondrial translation termination R-HSA-5419276 9.967111e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.967181e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.970088e-01 0.001 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.976792e-01 0.001 0 0
Regulation of Complement cascade R-HSA-977606 9.986002e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.988960e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.989174e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.989174e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.992885e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.993135e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.993454e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.995079e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.995327e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.995513e-01 0.000 0 0
Complement cascade R-HSA-166658 9.995525e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.996183e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.996977e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.998429e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999566e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999642e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999731e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999892e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999926e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999929e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999943e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999954e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999998e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 9.315138e-11 10.031 0 0
Cellular responses to stress R-HSA-2262752 3.999572e-09 8.398 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.164569e-09 8.210 0 0
Cellular responses to stimuli R-HSA-8953897 7.310399e-09 8.136 0 0
Cell Cycle R-HSA-1640170 9.141530e-09 8.039 0 0
M Phase R-HSA-68886 1.174852e-08 7.930 0 0
Cell Cycle, Mitotic R-HSA-69278 1.307543e-08 7.884 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.698702e-08 7.770 0 0
Metabolism of RNA R-HSA-8953854 2.124872e-07 6.673 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.766931e-07 6.558 0 0
Recycling pathway of L1 R-HSA-437239 4.320564e-07 6.364 0 0
Signaling by RAS mutants R-HSA-6802949 2.024215e-06 5.694 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.024215e-06 5.694 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.024215e-06 5.694 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.024215e-06 5.694 0 0
Cell junction organization R-HSA-446728 2.001784e-06 5.699 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.329222e-06 5.633 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.810428e-06 5.551 0 0
Aggrephagy R-HSA-9646399 2.756230e-06 5.560 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.563809e-06 5.448 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.184943e-06 5.378 0 0
HSF1-dependent transactivation R-HSA-3371571 5.203463e-06 5.284 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.570913e-06 5.254 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.615578e-06 5.179 0 0
Glycolysis R-HSA-70171 6.228029e-06 5.206 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.529856e-06 5.185 0 0
Interferon Signaling R-HSA-913531 7.547172e-06 5.122 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.939545e-06 5.100 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.630997e-06 5.064 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.862425e-06 5.006 0 0
Mitotic Prometaphase R-HSA-68877 9.367537e-06 5.028 0 0
Cell-Cell communication R-HSA-1500931 9.876758e-06 5.005 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.053207e-05 4.977 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.076277e-05 4.968 0 0
Apoptotic execution phase R-HSA-75153 1.093039e-05 4.961 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.296777e-05 4.887 0 0
L1CAM interactions R-HSA-373760 1.459207e-05 4.836 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.429967e-05 4.845 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.577023e-05 4.802 0 0
Mitotic Prophase R-HSA-68875 2.193822e-05 4.659 0 0
MAP2K and MAPK activation R-HSA-5674135 2.298269e-05 4.639 0 0
Nuclear import of Rev protein R-HSA-180746 2.696658e-05 4.569 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.837885e-05 4.315 0 0
Interleukin-12 signaling R-HSA-9020591 4.867217e-05 4.313 0 0
Glucose metabolism R-HSA-70326 5.312010e-05 4.275 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.596795e-05 4.252 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.879819e-05 4.162 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.879819e-05 4.162 0 0
Cellular Senescence R-HSA-2559583 7.268009e-05 4.139 0 0
Attenuation phase R-HSA-3371568 8.285368e-05 4.082 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.285368e-05 4.082 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.285368e-05 4.082 0 0
Cell-cell junction organization R-HSA-421270 8.535970e-05 4.069 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.646389e-05 4.063 0 0
Kinesins R-HSA-983189 9.779264e-05 4.010 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.019664e-04 3.992 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.134858e-04 3.945 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.230227e-04 3.910 0 0
Mitotic Anaphase R-HSA-68882 1.380890e-04 3.860 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.471365e-04 3.832 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.587939e-04 3.799 0 0
Adherens junctions interactions R-HSA-418990 1.567076e-04 3.805 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.761382e-04 3.754 0 0
Gap junction trafficking R-HSA-190828 1.860022e-04 3.730 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.860022e-04 3.730 0 0
Post NMDA receptor activation events R-HSA-438064 1.921826e-04 3.716 0 0
Interleukin-12 family signaling R-HSA-447115 1.921826e-04 3.716 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.034506e-04 3.692 0 0
HSF1 activation R-HSA-3371511 2.091323e-04 3.680 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.334517e-04 3.632 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.502271e-04 3.602 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.845650e-04 3.546 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.865961e-04 3.543 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.906256e-04 3.537 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.403008e-04 3.468 0 0
Axon guidance R-HSA-422475 3.408981e-04 3.467 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.474465e-04 3.459 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.758363e-04 3.425 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.805148e-04 3.420 0 0
Gap junction trafficking and regulation R-HSA-157858 3.806887e-04 3.419 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.607683e-04 3.337 0 0
tRNA processing in the nucleus R-HSA-6784531 4.941747e-04 3.306 0 0
Deadenylation of mRNA R-HSA-429947 5.544053e-04 3.256 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.544053e-04 3.256 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.576562e-04 3.254 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.217397e-04 3.206 0 0
Nervous system development R-HSA-9675108 6.946530e-04 3.158 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.976355e-04 3.156 0 0
Selective autophagy R-HSA-9663891 6.976355e-04 3.156 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.573851e-04 3.121 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.573851e-04 3.121 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.207137e-04 3.036 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.352480e-04 3.029 0 0
PKR-mediated signaling R-HSA-9833482 9.531650e-04 3.021 0 0
Separation of Sister Chromatids R-HSA-2467813 9.887116e-04 3.005 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.167719e-03 2.933 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.181888e-03 2.927 0 0
snRNP Assembly R-HSA-191859 1.281819e-03 2.892 0 0
Metabolism of non-coding RNA R-HSA-194441 1.281819e-03 2.892 0 0
HCMV Early Events R-HSA-9609690 1.247925e-03 2.904 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.247925e-03 2.904 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.432022e-03 2.844 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.473141e-03 2.832 0 0
Gene Silencing by RNA R-HSA-211000 1.508360e-03 2.821 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.572887e-03 2.803 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.572887e-03 2.803 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.572887e-03 2.803 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.659551e-03 2.780 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.554785e-03 2.808 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.698690e-03 2.770 0 0
Formation of annular gap junctions R-HSA-196025 1.802154e-03 2.744 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.832896e-03 2.737 0 0
mTORC1-mediated signalling R-HSA-166208 2.080598e-03 2.682 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.125053e-03 2.673 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.215417e-03 2.655 0 0
Gap junction degradation R-HSA-190873 2.462459e-03 2.609 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.451936e-03 2.610 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 2.462459e-03 2.609 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.442836e-03 2.612 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.472262e-03 2.607 0 0
Signaling by VEGF R-HSA-194138 2.534100e-03 2.596 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.916868e-03 2.535 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.106468e-03 2.508 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.152468e-03 2.501 0 0
Macroautophagy R-HSA-1632852 3.201367e-03 2.495 0 0
Gap junction assembly R-HSA-190861 3.220540e-03 2.492 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.270892e-03 2.485 0 0
Autophagy R-HSA-9612973 3.461640e-03 2.461 0 0
Regulation of CDH1 Function R-HSA-9764561 3.587719e-03 2.445 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.032569e-03 2.394 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.053081e-03 2.392 0 0
Signaling by ALK in cancer R-HSA-9700206 4.053081e-03 2.392 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.337208e-03 2.363 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.546082e-03 2.342 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.611258e-03 2.336 0 0
Signaling by ERBB2 R-HSA-1227986 4.782342e-03 2.320 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.782342e-03 2.320 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.611258e-03 2.336 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.883035e-03 2.311 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.242561e-03 2.280 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.310776e-03 2.275 0 0
Host Interactions of HIV factors R-HSA-162909 5.516728e-03 2.258 0 0
Influenza Infection R-HSA-168255 5.539948e-03 2.256 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.084967e-03 2.216 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.084967e-03 2.216 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.259735e-03 2.203 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.746445e-03 2.171 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.746445e-03 2.171 0 0
Interleukin-37 signaling R-HSA-9008059 6.938209e-03 2.159 0 0
mRNA 3'-end processing R-HSA-72187 7.280418e-03 2.138 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 7.411616e-03 2.130 0 0
Manipulation of host energy metabolism R-HSA-9636667 8.641166e-03 2.063 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.921974e-03 2.101 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.557882e-03 2.068 0 0
Breakdown of the nuclear lamina R-HSA-352238 8.641166e-03 2.063 0 0
HCMV Infection R-HSA-9609646 8.044500e-03 2.095 0 0
Developmental Biology R-HSA-1266738 7.642038e-03 2.117 0 0
mRNA Splicing R-HSA-72172 8.935969e-03 2.049 0 0
Programmed Cell Death R-HSA-5357801 9.331492e-03 2.030 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.570625e-03 2.019 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.006512e-02 1.997 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.010925e-02 1.995 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.026668e-02 1.989 0 0
Apoptosis R-HSA-109581 1.044410e-02 1.981 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.070838e-02 1.970 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.079610e-02 1.967 0 0
Signaling by Interleukins R-HSA-449147 1.088680e-02 1.963 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.108671e-02 1.955 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.110888e-02 1.954 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.126798e-02 1.948 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.143226e-02 1.942 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.143226e-02 1.942 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.206010e-02 1.919 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.471591e-02 1.832 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.287272e-02 1.890 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.395680e-02 1.855 0 0
MAPK family signaling cascades R-HSA-5683057 1.269580e-02 1.896 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.271021e-02 1.896 0 0
rRNA processing R-HSA-72312 1.438723e-02 1.842 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.452076e-02 1.838 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.490649e-02 1.827 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.490649e-02 1.827 0 0
Signalling to ERK5 R-HSA-198765 1.490649e-02 1.827 1 1
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.490649e-02 1.827 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.490649e-02 1.827 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.490649e-02 1.827 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.490649e-02 1.827 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.490649e-02 1.827 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.490649e-02 1.827 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.490649e-02 1.827 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.490649e-02 1.827 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.490649e-02 1.827 0 0
Long-term potentiation R-HSA-9620244 1.506436e-02 1.822 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.569964e-02 1.804 0 0
G2/M Transition R-HSA-69275 1.570448e-02 1.804 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.578167e-02 1.802 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.594086e-02 1.797 0 0
Gluconeogenesis R-HSA-70263 1.604881e-02 1.795 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.676911e-02 1.775 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.702323e-02 1.769 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.706655e-02 1.768 0 0
Semaphorin interactions R-HSA-373755 1.826256e-02 1.738 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.847847e-02 1.733 0 0
Membrane Trafficking R-HSA-199991 1.848494e-02 1.733 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.889185e-02 1.724 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.889185e-02 1.724 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.272490e-02 1.643 0 0
Nucleotide Excision Repair R-HSA-5696398 2.129077e-02 1.672 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.260331e-02 1.646 0 0
Signaling by Hippo R-HSA-2028269 1.949903e-02 1.710 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.248800e-02 1.648 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.248800e-02 1.648 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.272911e-02 1.643 0 0
Developmental Cell Lineages R-HSA-9734767 2.371271e-02 1.625 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.388212e-02 1.622 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.388212e-02 1.622 0 0
Smooth Muscle Contraction R-HSA-445355 2.414027e-02 1.617 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.497271e-02 1.603 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.574126e-02 1.589 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.159095e-02 1.500 0 0
Signaling by MAP2K mutants R-HSA-9652169 3.159095e-02 1.500 0 0
PECAM1 interactions R-HSA-210990 2.745633e-02 1.561 0 0
ERKs are inactivated R-HSA-202670 3.267049e-02 1.486 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.926297e-02 1.534 0 0
ERK/MAPK targets R-HSA-198753 3.305626e-02 1.481 0 0
Signal transduction by L1 R-HSA-445144 2.926297e-02 1.534 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.159095e-02 1.500 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.267049e-02 1.486 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.833836e-02 1.548 0 0
MTOR signalling R-HSA-165159 2.946185e-02 1.531 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.305626e-02 1.481 0 0
Basigin interactions R-HSA-210991 3.305626e-02 1.481 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.152415e-02 1.501 0 0
Signal Transduction R-HSA-162582 2.824364e-02 1.549 1 0
Hemostasis R-HSA-109582 2.941930e-02 1.531 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.305626e-02 1.481 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.074631e-02 1.512 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.354868e-02 1.474 0 0
HIV Life Cycle R-HSA-162587 3.429512e-02 1.465 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.466916e-02 1.460 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.484132e-02 1.458 0 0
Cell Cycle Checkpoints R-HSA-69620 3.514932e-02 1.454 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.548186e-02 1.450 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.548186e-02 1.450 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.548186e-02 1.450 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.558377e-02 1.449 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.565979e-02 1.448 0 0
Cellular response to starvation R-HSA-9711097 3.568010e-02 1.448 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.641259e-02 1.439 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.708930e-02 1.431 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.836212e-02 1.416 0 0
Striated Muscle Contraction R-HSA-390522 3.883993e-02 1.411 0 0
Centrosome maturation R-HSA-380287 4.014696e-02 1.396 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.173844e-02 1.379 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.173844e-02 1.379 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.173844e-02 1.379 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.173844e-02 1.379 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.178828e-02 1.379 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.224331e-02 1.374 1 0
RAF activation R-HSA-5673000 4.238541e-02 1.373 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.335828e-02 1.363 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.452335e-02 1.351 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.452335e-02 1.351 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.500688e-02 1.347 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.500688e-02 1.347 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.557164e-02 1.341 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.608199e-02 1.336 0 0
PERK regulates gene expression R-HSA-381042 4.611961e-02 1.336 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.630689e-02 1.334 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.655579e-02 1.332 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.786932e-02 1.320 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.786932e-02 1.320 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.786932e-02 1.320 0 0
Protein folding R-HSA-391251 4.868353e-02 1.313 0 0
EPH-Ephrin signaling R-HSA-2682334 4.868353e-02 1.313 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.346416e-02 1.272 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.503416e-02 1.187 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.571342e-02 1.182 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.571342e-02 1.182 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.571342e-02 1.182 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.727360e-02 1.172 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.763915e-02 1.170 0 0
Translation initiation complex formation R-HSA-72649 6.875670e-02 1.163 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.714022e-02 1.243 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.146961e-02 1.146 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.146961e-02 1.146 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 6.352500e-02 1.197 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 6.352500e-02 1.197 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.874663e-02 1.231 0 0
PTEN Regulation R-HSA-6807070 5.994818e-02 1.222 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.613728e-02 1.251 0 0
ESR-mediated signaling R-HSA-8939211 5.395262e-02 1.268 0 0
Cilium Assembly R-HSA-5617833 6.264855e-02 1.203 0 0
HIV Infection R-HSA-162906 6.765243e-02 1.170 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.814359e-02 1.167 0 0
Platelet degranulation R-HSA-114608 6.690558e-02 1.175 0 0
Signaling by LTK in cancer R-HSA-9842640 6.503416e-02 1.187 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.959695e-02 1.157 0 0
tRNA processing R-HSA-72306 5.748724e-02 1.240 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.938495e-02 1.159 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.251069e-02 1.140 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.323891e-02 1.135 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.323891e-02 1.135 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.350394e-02 1.134 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.489284e-02 1.126 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.756896e-02 1.110 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.796389e-02 1.108 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.880700e-02 1.103 0 0
Late endosomal microautophagy R-HSA-9615710 7.946320e-02 1.100 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.946320e-02 1.100 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.195462e-02 1.086 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.195462e-02 1.086 0 0
Peptide chain elongation R-HSA-156902 8.203107e-02 1.086 0 0
Chromatin modifying enzymes R-HSA-3247509 8.205251e-02 1.086 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.209629e-02 1.086 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.281220e-02 1.082 0 0
Activation of the pre-replicative complex R-HSA-68962 8.594135e-02 1.066 0 0
Homology Directed Repair R-HSA-5693538 8.709932e-02 1.060 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.770314e-02 1.057 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.770314e-02 1.057 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.770314e-02 1.057 0 0
Hereditary fructose intolerance R-HSA-5657560 8.770314e-02 1.057 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 8.770314e-02 1.057 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.770314e-02 1.057 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.770314e-02 1.057 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 8.770314e-02 1.057 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 8.770314e-02 1.057 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.823827e-02 1.054 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.928932e-02 1.049 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.960521e-02 1.048 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.066051e-02 1.043 0 0
Regulation of beta-cell development R-HSA-186712 9.121814e-02 1.040 0 0
Type I hemidesmosome assembly R-HSA-446107 9.161547e-02 1.038 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 9.161547e-02 1.038 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 9.161547e-02 1.038 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 9.161547e-02 1.038 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 9.161547e-02 1.038 0 0
RSK activation R-HSA-444257 9.161547e-02 1.038 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 9.161547e-02 1.038 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.384474e-02 1.028 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.671601e-02 1.015 0 0
IRE1alpha activates chaperones R-HSA-381070 9.747078e-02 1.011 0 0
Nucleosome assembly R-HSA-774815 9.962886e-02 1.002 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.962886e-02 1.002 0 0
Diseases of mitotic cell cycle R-HSA-9675126 9.963588e-02 1.002 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.286304e-01 0.891 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.286304e-01 0.891 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.286304e-01 0.891 0 0
ALK mutants bind TKIs R-HSA-9700645 1.058983e-01 0.975 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.207285e-01 0.918 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 1.360284e-01 0.866 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.517261e-01 0.819 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.517261e-01 0.819 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.289554e-01 0.890 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.289554e-01 0.890 0 0
FGFR2 alternative splicing R-HSA-6803529 1.393000e-01 0.856 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.219229e-01 0.914 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.015903e-01 0.993 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.154205e-01 0.938 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.141530e-01 0.943 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 1.517261e-01 0.819 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.499133e-01 0.824 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.272959e-01 0.895 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.207285e-01 0.918 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.297877e-01 0.887 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.398270e-01 0.854 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.058983e-01 0.975 0 0
HATs acetylate histones R-HSA-3214847 1.377334e-01 0.861 0 0
Transport of connexins along the secretory pathway R-HSA-190827 1.286304e-01 0.891 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 1.058983e-01 0.975 0 0
Unwinding of DNA R-HSA-176974 1.058983e-01 0.975 0 0
Intraflagellar transport R-HSA-5620924 1.180153e-01 0.928 0 0
MAP kinase activation R-HSA-450294 1.011913e-01 0.995 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.117125e-01 0.952 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.041993e-01 0.982 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.058983e-01 0.975 0 0
Oncogene Induced Senescence R-HSA-2559585 1.297877e-01 0.887 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.302941e-01 0.885 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.058983e-01 0.975 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.289554e-01 0.890 0 0
Chromatin organization R-HSA-4839726 1.192305e-01 0.924 0 0
Vesicle-mediated transport R-HSA-5653656 1.418612e-01 0.848 0 0
Neurexins and neuroligins R-HSA-6794361 1.448034e-01 0.839 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.190749e-01 0.924 0 0
Signalling to ERKs R-HSA-187687 1.297877e-01 0.887 0 0
Inhibition of membrane repair R-HSA-9635644 1.286304e-01 0.891 0 0
Oligomerization of connexins into connexons R-HSA-190704 1.286304e-01 0.891 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.063842e-01 0.973 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.461222e-01 0.835 0 0
Signal attenuation R-HSA-74749 1.207285e-01 0.918 0 0
Suppression of apoptosis R-HSA-9635465 1.360284e-01 0.866 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.403070e-01 0.853 0 0
Muscle contraction R-HSA-397014 1.199298e-01 0.921 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.270927e-01 0.896 1 0
Signaling by NODAL R-HSA-1181150 1.091520e-01 0.962 0 0
RUNX2 regulates bone development R-HSA-8941326 1.378570e-01 0.861 0 0
MHC class II antigen presentation R-HSA-2132295 1.041993e-01 0.982 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.281455e-01 0.892 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.207285e-01 0.918 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.289554e-01 0.890 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.360284e-01 0.866 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.289554e-01 0.890 0 0
Immune System R-HSA-168256 1.360667e-01 0.866 0 0
Inositol phosphate metabolism R-HSA-1483249 1.216924e-01 0.915 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.117125e-01 0.952 0 0
Signaling by PTK6 R-HSA-8848021 1.117125e-01 0.952 0 0
Formation of apoptosome R-HSA-111458 1.207285e-01 0.918 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.517261e-01 0.819 0 0
Growth hormone receptor signaling R-HSA-982772 1.499133e-01 0.824 0 0
SLC transporter disorders R-HSA-5619102 1.492532e-01 0.826 0 0
Meiotic synapsis R-HSA-1221632 1.518778e-01 0.819 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.518778e-01 0.819 0 0
Interleukin-17 signaling R-HSA-448424 1.526098e-01 0.816 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.587355e-01 0.799 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.589353e-01 0.799 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.607757e-01 0.794 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.607757e-01 0.794 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.632110e-01 0.787 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.677239e-01 0.775 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.677239e-01 0.775 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 1.677239e-01 0.775 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.677239e-01 0.775 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.677239e-01 0.775 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 1.677239e-01 0.775 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.677239e-01 0.775 0 0
C6 deamination of adenosine R-HSA-75102 1.677239e-01 0.775 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 1.677239e-01 0.775 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 1.677553e-01 0.775 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.677553e-01 0.775 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.677553e-01 0.775 0 0
OAS antiviral response R-HSA-8983711 1.677553e-01 0.775 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.681765e-01 0.774 0 0
TGFBR3 expression R-HSA-9839394 1.718673e-01 0.765 0 0
Tight junction interactions R-HSA-420029 1.718673e-01 0.765 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.718673e-01 0.765 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.719191e-01 0.765 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.739310e-01 0.760 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.739310e-01 0.760 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.739310e-01 0.760 0 0
Signaling by ERBB4 R-HSA-1236394 1.785708e-01 0.748 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.785708e-01 0.748 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.794730e-01 0.746 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.799652e-01 0.745 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.809677e-01 0.742 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.809677e-01 0.742 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.815416e-01 0.741 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.821421e-01 0.740 0 0
Myogenesis R-HSA-525793 1.831686e-01 0.737 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.831686e-01 0.737 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.831686e-01 0.737 0 0
Formation of axial mesoderm R-HSA-9796292 1.840548e-01 0.735 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.840548e-01 0.735 0 0
Frs2-mediated activation R-HSA-170968 1.840548e-01 0.735 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.840548e-01 0.735 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.840548e-01 0.735 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.875540e-01 0.727 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.050658e-01 0.688 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.050658e-01 0.688 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.050658e-01 0.688 0 0
Regulation of gap junction activity R-HSA-191650 2.407345e-01 0.618 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.407345e-01 0.618 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.407345e-01 0.618 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.407345e-01 0.618 0 0
Defective F9 activation R-HSA-9673221 2.748047e-01 0.561 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.748047e-01 0.561 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.748047e-01 0.561 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.073481e-01 0.512 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.073481e-01 0.512 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.073481e-01 0.512 0 0
Signaling by MAPK mutants R-HSA-9652817 3.073481e-01 0.512 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.005682e-01 0.698 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.384331e-01 0.471 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.384331e-01 0.471 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.384331e-01 0.471 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.384331e-01 0.471 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 2.172436e-01 0.663 0 0
Erythropoietin activates RAS R-HSA-9027284 2.172436e-01 0.663 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.172436e-01 0.663 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.172436e-01 0.663 0 0
Phosphorylation of the APC/C R-HSA-176412 2.340333e-01 0.631 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.681247e-01 0.434 0 0
Disinhibition of SNARE formation R-HSA-114516 3.681247e-01 0.434 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.681247e-01 0.434 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.677845e-01 0.572 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.677845e-01 0.572 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.015145e-01 0.521 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 3.182899e-01 0.497 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.182899e-01 0.497 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.349678e-01 0.475 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.349678e-01 0.475 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.349678e-01 0.475 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.788968e-01 0.555 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.515233e-01 0.454 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.515233e-01 0.454 0 0
Dual Incision in GG-NER R-HSA-5696400 2.912671e-01 0.536 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.912671e-01 0.536 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.679337e-01 0.434 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.161033e-01 0.500 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.285411e-01 0.483 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.112671e-01 0.675 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.177585e-01 0.662 0 0
HDACs deacetylate histones R-HSA-3214815 3.283607e-01 0.484 0 0
Viral mRNA Translation R-HSA-192823 2.720027e-01 0.565 0 0
Neutrophil degranulation R-HSA-6798695 2.157505e-01 0.666 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.650239e-01 0.577 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.679337e-01 0.434 0 0
Integrin signaling R-HSA-354192 2.665783e-01 0.574 0 0
DNA Damage Bypass R-HSA-73893 2.673016e-01 0.573 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.338176e-01 0.476 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.278532e-01 0.642 0 0
p38MAPK events R-HSA-171007 2.172436e-01 0.663 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.340333e-01 0.631 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.508936e-01 0.601 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.679337e-01 0.434 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.748047e-01 0.561 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.681247e-01 0.434 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.508936e-01 0.601 0 0
Trafficking of AMPA receptors R-HSA-399719 2.421588e-01 0.616 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.971204e-01 0.705 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.682777e-01 0.434 0 0
Ephrin signaling R-HSA-3928664 2.846692e-01 0.546 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.679337e-01 0.434 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.982622e-01 0.525 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.982622e-01 0.525 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.005682e-01 0.698 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.172436e-01 0.663 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.677845e-01 0.572 0 0
Platelet sensitization by LDL R-HSA-432142 2.846692e-01 0.546 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.220338e-01 0.492 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.720240e-01 0.565 0 0
DNA Double Strand Break Response R-HSA-5693606 2.633890e-01 0.579 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.748047e-01 0.561 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.681247e-01 0.434 0 0
Eukaryotic Translation Termination R-HSA-72764 2.177585e-01 0.662 0 0
Chromosome Maintenance R-HSA-73886 2.828539e-01 0.548 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.748047e-01 0.561 0 0
Pentose phosphate pathway disease R-HSA-6791465 3.073481e-01 0.512 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.340333e-01 0.631 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.340333e-01 0.631 0 0
SOS-mediated signalling R-HSA-112412 3.681247e-01 0.434 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.508936e-01 0.601 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.846692e-01 0.546 0 0
Signalling to RAS R-HSA-167044 3.349678e-01 0.475 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.515233e-01 0.454 0 0
Notch-HLH transcription pathway R-HSA-350054 3.679337e-01 0.434 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.161033e-01 0.500 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.360850e-01 0.474 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.015145e-01 0.521 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.474047e-01 0.607 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.548188e-01 0.594 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.833451e-01 0.548 0 0
Neurofascin interactions R-HSA-447043 3.384331e-01 0.471 0 0
DNA Replication R-HSA-69306 2.638981e-01 0.579 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.132890e-01 0.671 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.073481e-01 0.512 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.679337e-01 0.434 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.533902e-01 0.452 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 2.583198e-01 0.588 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.088888e-01 0.510 0 0
Regulation of BACH1 activity R-HSA-9708530 2.340333e-01 0.631 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 3.015145e-01 0.521 0 0
Synthesis of DNA R-HSA-69239 3.075579e-01 0.512 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.427374e-01 0.465 0 0
Heme signaling R-HSA-9707616 2.213002e-01 0.655 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 3.015145e-01 0.521 0 0
TBC/RABGAPs R-HSA-8854214 2.087201e-01 0.680 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.061628e-01 0.686 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.781232e-01 0.422 0 0
Interferon gamma signaling R-HSA-877300 2.981236e-01 0.526 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.407345e-01 0.618 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.384331e-01 0.471 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.681247e-01 0.434 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.508936e-01 0.601 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.300907e-01 0.638 0 0
DNA strand elongation R-HSA-69190 2.543269e-01 0.595 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.665783e-01 0.574 0 0
S Phase R-HSA-69242 2.364207e-01 0.626 0 0
Gene expression (Transcription) R-HSA-74160 2.427330e-01 0.615 0 0
EGFR downregulation R-HSA-182971 2.421588e-01 0.616 0 0
Prolonged ERK activation events R-HSA-169893 2.340333e-01 0.631 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.573145e-01 0.590 0 0
Signaling by KIT in disease R-HSA-9669938 3.679337e-01 0.434 0 0
G2/M Checkpoints R-HSA-69481 2.096261e-01 0.679 0 0
Malate-aspartate shuttle R-HSA-9856872 2.005682e-01 0.698 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.665783e-01 0.574 0 0
Selenocysteine synthesis R-HSA-2408557 2.580959e-01 0.588 0 0
Deubiquitination R-HSA-5688426 2.855669e-01 0.544 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.260103e-01 0.646 0 0
The NLRP1 inflammasome R-HSA-844455 2.050658e-01 0.688 0 0
NrCAM interactions R-HSA-447038 2.748047e-01 0.561 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.340333e-01 0.631 0 0
Regulation of PTEN localization R-HSA-8948747 3.681247e-01 0.434 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.681247e-01 0.434 0 0
Ribavirin ADME R-HSA-9755088 3.515233e-01 0.454 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.533902e-01 0.452 0 0
Sensory processing of sound R-HSA-9659379 2.132890e-01 0.671 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.580959e-01 0.588 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.787048e-01 0.422 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.673016e-01 0.573 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.285411e-01 0.483 0 0
HCMV Late Events R-HSA-9610379 2.865811e-01 0.543 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.073481e-01 0.512 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.073481e-01 0.512 0 0
Nef and signal transduction R-HSA-164944 3.384331e-01 0.471 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.681247e-01 0.434 0 0
CHL1 interactions R-HSA-447041 3.681247e-01 0.434 0 0
Synthesis of PG R-HSA-1483148 2.508936e-01 0.601 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.734158e-01 0.428 0 0
Transmission across Chemical Synapses R-HSA-112315 3.154288e-01 0.501 0 0
Signaling by FGFR2 R-HSA-5654738 2.204992e-01 0.657 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 2.677845e-01 0.572 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 3.071007e-01 0.513 0 0
Signaling by EGFR R-HSA-177929 3.386489e-01 0.470 0 0
Signaling by NTRKs R-HSA-166520 2.364207e-01 0.626 1 0
Signaling by TGFB family members R-HSA-9006936 3.039397e-01 0.517 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.340333e-01 0.631 0 0
Signaling by ROBO receptors R-HSA-376176 2.253523e-01 0.647 0 0
Viral Infection Pathways R-HSA-9824446 2.010134e-01 0.697 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.386489e-01 0.470 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.729969e-01 0.564 0 0
Signaling by NOTCH1 R-HSA-1980143 3.427728e-01 0.465 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.527815e-01 0.597 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.384331e-01 0.471 0 0
NGF-stimulated transcription R-HSA-9031628 2.573145e-01 0.590 0 0
Nephron development R-HSA-9831926 2.846692e-01 0.546 0 0
Regulation of TP53 Activity R-HSA-5633007 3.039397e-01 0.517 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.508936e-01 0.601 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.679337e-01 0.434 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.403168e-01 0.619 0 0
Signaling by Activin R-HSA-1502540 2.172436e-01 0.663 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.515233e-01 0.454 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.796406e-01 0.421 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.386489e-01 0.470 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.172436e-01 0.663 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.976387e-01 0.526 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.668695e-01 0.574 0 0
SARS-CoV Infections R-HSA-9679506 2.070552e-01 0.684 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.817975e-01 0.550 0 0
Apoptotic factor-mediated response R-HSA-111471 2.846692e-01 0.546 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.798365e-01 0.420 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.798365e-01 0.420 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.798365e-01 0.420 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.798365e-01 0.420 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.798365e-01 0.420 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.798365e-01 0.420 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.841788e-01 0.415 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.841788e-01 0.415 0 0
Syndecan interactions R-HSA-3000170 3.841788e-01 0.415 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.841788e-01 0.415 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.844323e-01 0.415 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.844323e-01 0.415 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.844323e-01 0.415 0 0
Signaling by FGFR R-HSA-190236 3.844323e-01 0.415 0 0
DNA Repair R-HSA-73894 3.847710e-01 0.415 0 0
Amyloid fiber formation R-HSA-977225 3.876913e-01 0.412 0 0
Intra-Golgi traffic R-HSA-6811438 3.904179e-01 0.408 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.964855e-01 0.402 0 0
MET receptor recycling R-HSA-8875656 3.964855e-01 0.402 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.964855e-01 0.402 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.964855e-01 0.402 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.964855e-01 0.402 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.964855e-01 0.402 0 0
Activation of RAS in B cells R-HSA-1169092 3.964855e-01 0.402 0 0
phospho-PLA2 pathway R-HSA-111995 3.964855e-01 0.402 0 0
SLC-mediated bile acid transport R-HSA-9958517 3.964855e-01 0.402 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.964855e-01 0.402 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.964855e-01 0.402 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.977163e-01 0.400 0 0
Neuronal System R-HSA-112316 3.979206e-01 0.400 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.002405e-01 0.398 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.002405e-01 0.398 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.002405e-01 0.398 0 0
Neurodegenerative Diseases R-HSA-8863678 4.002405e-01 0.398 0 0
Mitochondrial protein import R-HSA-1268020 4.003523e-01 0.398 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.003523e-01 0.398 0 0
Hedgehog 'off' state R-HSA-5610787 4.005883e-01 0.397 0 0
Ca-dependent events R-HSA-111996 4.026511e-01 0.395 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.104083e-01 0.387 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.104083e-01 0.387 0 0
Defective pyroptosis R-HSA-9710421 4.148129e-01 0.382 0 0
Signaling by FGFR4 R-HSA-5654743 4.148129e-01 0.382 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.148129e-01 0.382 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.161024e-01 0.381 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.161024e-01 0.381 0 0
Meiosis R-HSA-1500620 4.235129e-01 0.373 0 0
WNT mediated activation of DVL R-HSA-201688 4.235751e-01 0.373 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.235751e-01 0.373 0 0
Calcineurin activates NFAT R-HSA-2025928 4.235751e-01 0.373 0 0
mRNA Editing R-HSA-75072 4.235751e-01 0.373 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.235751e-01 0.373 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.235751e-01 0.373 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.235751e-01 0.373 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.235751e-01 0.373 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.317501e-01 0.365 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.317501e-01 0.365 0 0
TRP channels R-HSA-3295583 4.317501e-01 0.365 0 0
Parasite infection R-HSA-9664407 4.319582e-01 0.365 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.319582e-01 0.365 0 0
Leishmania phagocytosis R-HSA-9664417 4.319582e-01 0.365 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.325607e-01 0.364 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.325607e-01 0.364 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.327984e-01 0.364 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.388058e-01 0.358 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.388868e-01 0.358 0 0
Signaling by FGFR3 R-HSA-5654741 4.388868e-01 0.358 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.471711e-01 0.350 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.471711e-01 0.350 0 0
Cristae formation R-HSA-8949613 4.471711e-01 0.350 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.471711e-01 0.350 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.471711e-01 0.350 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.488018e-01 0.348 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.494502e-01 0.347 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.494502e-01 0.347 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.494502e-01 0.347 0 0
Regulation of CDH11 function R-HSA-9762292 4.494502e-01 0.347 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.494502e-01 0.347 0 0
2-LTR circle formation R-HSA-164843 4.494502e-01 0.347 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.494502e-01 0.347 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 4.494502e-01 0.347 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.494502e-01 0.347 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.494502e-01 0.347 0 0
Josephin domain DUBs R-HSA-5689877 4.494502e-01 0.347 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.494502e-01 0.347 0 0
Signaling by TGFBR3 R-HSA-9839373 4.507823e-01 0.346 0 0
Disorders of transmembrane transporters R-HSA-5619115 4.532051e-01 0.344 0 0
Diseases of programmed cell death R-HSA-9645723 4.589326e-01 0.338 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.623540e-01 0.335 0 0
Inflammasomes R-HSA-622312 4.623540e-01 0.335 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.623540e-01 0.335 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.625734e-01 0.335 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.726137e-01 0.325 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.741653e-01 0.324 0 0
vRNP Assembly R-HSA-192905 4.741653e-01 0.324 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.741653e-01 0.324 0 0
Bicarbonate transporters R-HSA-425381 4.741653e-01 0.324 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.741653e-01 0.324 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.741653e-01 0.324 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.741653e-01 0.324 0 0
Co-stimulation by CD28 R-HSA-389356 4.742531e-01 0.324 0 0
Signaling by Erythropoietin R-HSA-9006335 4.772893e-01 0.321 0 0
DNA methylation R-HSA-5334118 4.772893e-01 0.321 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.772893e-01 0.321 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.772893e-01 0.321 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.772893e-01 0.321 0 0
DARPP-32 events R-HSA-180024 4.772893e-01 0.321 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.772893e-01 0.321 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.796041e-01 0.319 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.804884e-01 0.318 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.807382e-01 0.318 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.883273e-01 0.311 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.883273e-01 0.311 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.919686e-01 0.308 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.919686e-01 0.308 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.919686e-01 0.308 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.919686e-01 0.308 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.930509e-01 0.307 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.977724e-01 0.303 0 0
Integration of provirus R-HSA-162592 4.977724e-01 0.303 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.977724e-01 0.303 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 4.977724e-01 0.303 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.977724e-01 0.303 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.977724e-01 0.303 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.063847e-01 0.296 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.116056e-01 0.291 0 0
Signaling by NOTCH4 R-HSA-9013694 5.193487e-01 0.285 0 0
Interleukin-1 family signaling R-HSA-446652 5.196345e-01 0.284 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 5.197344e-01 0.284 0 0
Orc1 removal from chromatin R-HSA-68949 5.197344e-01 0.284 0 0
Ub-specific processing proteases R-HSA-5689880 5.198883e-01 0.284 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.203210e-01 0.284 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.203210e-01 0.284 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.203210e-01 0.284 0 0
Polymerase switching R-HSA-69091 5.203210e-01 0.284 0 0
Leading Strand Synthesis R-HSA-69109 5.203210e-01 0.284 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.203210e-01 0.284 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.203210e-01 0.284 0 0
MET activates RAS signaling R-HSA-8851805 5.203210e-01 0.284 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.203210e-01 0.284 0 0
Regulation of IFNG signaling R-HSA-877312 5.203210e-01 0.284 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.203210e-01 0.284 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.203210e-01 0.284 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.203210e-01 0.284 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.203210e-01 0.284 0 0
G0 and Early G1 R-HSA-1538133 5.205317e-01 0.284 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.205317e-01 0.284 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.307689e-01 0.275 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.327465e-01 0.273 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.344048e-01 0.272 0 0
Nuclear RNA decay R-HSA-9930044 5.344048e-01 0.272 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.344048e-01 0.272 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.344048e-01 0.272 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.344048e-01 0.272 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.344048e-01 0.272 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.359426e-01 0.271 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.381402e-01 0.269 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.416598e-01 0.266 0 0
Processing of SMDT1 R-HSA-8949664 5.418585e-01 0.266 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.418585e-01 0.266 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.418585e-01 0.266 0 0
Maturation of nucleoprotein R-HSA-9683610 5.418585e-01 0.266 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.418585e-01 0.266 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.480000e-01 0.261 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.480000e-01 0.261 0 0
RNA Polymerase I Transcription R-HSA-73864 5.565535e-01 0.254 0 0
G alpha (12/13) signalling events R-HSA-416482 5.565535e-01 0.254 0 0
SLC-mediated transport of organic anions R-HSA-9955298 5.565535e-01 0.254 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.613142e-01 0.251 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.613142e-01 0.251 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.613142e-01 0.251 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.613142e-01 0.251 0 0
Signaling by NOTCH2 R-HSA-1980145 5.613142e-01 0.251 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 5.613142e-01 0.251 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.624303e-01 0.250 0 0
Regulation of KIT signaling R-HSA-1433559 5.624303e-01 0.250 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.624303e-01 0.250 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.624303e-01 0.250 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.624303e-01 0.250 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.624303e-01 0.250 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.624303e-01 0.250 0 0
Ion homeostasis R-HSA-5578775 5.629961e-01 0.249 0 0
NRAGE signals death through JNK R-HSA-193648 5.629961e-01 0.249 0 0
Signaling by FGFR1 R-HSA-5654736 5.629961e-01 0.249 0 0
Ribosome-associated quality control R-HSA-9948299 5.678157e-01 0.246 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.743454e-01 0.241 0 0
Signaling by MET R-HSA-6806834 5.745661e-01 0.241 0 0
Translesion synthesis by REV1 R-HSA-110312 5.820795e-01 0.235 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.820795e-01 0.235 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.820795e-01 0.235 0 0
Protein methylation R-HSA-8876725 5.820795e-01 0.235 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.820795e-01 0.235 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.820795e-01 0.235 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.820795e-01 0.235 0 0
Biotin transport and metabolism R-HSA-196780 5.820795e-01 0.235 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.820795e-01 0.235 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.820795e-01 0.235 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.820795e-01 0.235 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.820795e-01 0.235 0 0
DCC mediated attractive signaling R-HSA-418885 5.820795e-01 0.235 0 0
p75NTR signals via NF-kB R-HSA-193639 5.820795e-01 0.235 0 0
Dual incision in TC-NER R-HSA-6782135 5.837171e-01 0.234 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.837171e-01 0.234 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.837171e-01 0.234 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.870921e-01 0.231 0 0
RNA Polymerase III Transcription R-HSA-74158 5.870921e-01 0.231 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.870921e-01 0.231 0 0
FLT3 signaling in disease R-HSA-9682385 5.870921e-01 0.231 0 0
Calmodulin induced events R-HSA-111933 5.870921e-01 0.231 0 0
CaM pathway R-HSA-111997 5.870921e-01 0.231 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 5.870921e-01 0.231 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.870921e-01 0.231 0 0
Translation R-HSA-72766 5.884937e-01 0.230 0 0
Selenoamino acid metabolism R-HSA-2408522 5.960716e-01 0.225 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.995536e-01 0.222 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.001217e-01 0.222 0 0
Translesion synthesis by POLI R-HSA-5656121 6.008475e-01 0.221 0 0
Killing mechanisms R-HSA-9664420 6.008475e-01 0.221 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.008475e-01 0.221 0 0
Fructose catabolism R-HSA-70350 6.008475e-01 0.221 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.008475e-01 0.221 0 0
Differentiation of T cells R-HSA-9945266 6.008475e-01 0.221 0 0
Negative regulation of FLT3 R-HSA-9706369 6.008475e-01 0.221 0 0
Opioid Signalling R-HSA-111885 6.075494e-01 0.216 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.117297e-01 0.213 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.117297e-01 0.213 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.117297e-01 0.213 0 0
PLC beta mediated events R-HSA-112043 6.136014e-01 0.212 0 0
Translesion synthesis by POLK R-HSA-5655862 6.187738e-01 0.208 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.187738e-01 0.208 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.187738e-01 0.208 0 0
Heme assimilation R-HSA-9927020 6.187738e-01 0.208 0 0
Coenzyme A biosynthesis R-HSA-196783 6.187738e-01 0.208 0 0
Disorders of Developmental Biology R-HSA-9675151 6.187738e-01 0.208 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.187738e-01 0.208 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 6.187738e-01 0.208 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.232361e-01 0.205 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.236210e-01 0.205 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.236210e-01 0.205 0 0
Toll-like Receptor Cascades R-HSA-168898 6.261995e-01 0.203 0 0
Cell surface interactions at the vascular wall R-HSA-202733 6.324043e-01 0.199 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.352284e-01 0.197 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.352284e-01 0.197 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.358960e-01 0.197 0 0
Glycogen storage diseases R-HSA-3229121 6.358960e-01 0.197 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.358960e-01 0.197 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.358960e-01 0.197 0 0
Choline catabolism R-HSA-6798163 6.358960e-01 0.197 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.358960e-01 0.197 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.358960e-01 0.197 0 0
Insulin receptor signalling cascade R-HSA-74751 6.420081e-01 0.192 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.420081e-01 0.192 0 0
Stimuli-sensing channels R-HSA-2672351 6.444561e-01 0.191 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.465536e-01 0.189 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.465536e-01 0.189 0 0
FLT3 Signaling R-HSA-9607240 6.465536e-01 0.189 0 0
Signaling by NOTCH R-HSA-157118 6.472642e-01 0.189 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.492174e-01 0.188 0 0
Potential therapeutics for SARS R-HSA-9679191 6.510963e-01 0.186 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.522502e-01 0.186 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.522502e-01 0.186 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.522502e-01 0.186 0 0
Polo-like kinase mediated events R-HSA-156711 6.522502e-01 0.186 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 6.522502e-01 0.186 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.522502e-01 0.186 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.522502e-01 0.186 0 0
Tie2 Signaling R-HSA-210993 6.522502e-01 0.186 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.522502e-01 0.186 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.522502e-01 0.186 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.540406e-01 0.184 0 0
HIV Transcription Initiation R-HSA-167161 6.575983e-01 0.182 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.575983e-01 0.182 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.575983e-01 0.182 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.575983e-01 0.182 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 6.575983e-01 0.182 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 6.601116e-01 0.180 0 0
Base Excision Repair R-HSA-73884 6.657506e-01 0.177 0 0
Adipogenesis R-HSA-9843745 6.667985e-01 0.176 0 0
Translesion Synthesis by POLH R-HSA-110320 6.678708e-01 0.175 0 0
Regulation of signaling by CBL R-HSA-912631 6.678708e-01 0.175 0 0
The NLRP3 inflammasome R-HSA-844456 6.678708e-01 0.175 0 0
Other interleukin signaling R-HSA-449836 6.678708e-01 0.175 0 0
Rap1 signalling R-HSA-392517 6.678708e-01 0.175 0 0
Diseases of hemostasis R-HSA-9671793 6.678708e-01 0.175 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.678708e-01 0.175 0 0
Maturation of nucleoprotein R-HSA-9694631 6.678708e-01 0.175 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 6.678708e-01 0.175 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.678708e-01 0.175 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.683651e-01 0.175 0 0
G-protein mediated events R-HSA-112040 6.689118e-01 0.175 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.689118e-01 0.175 0 0
Cellular response to chemical stress R-HSA-9711123 6.704375e-01 0.174 0 0
FCERI mediated MAPK activation R-HSA-2871796 6.723669e-01 0.172 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.733407e-01 0.172 0 0
Transcription of the HIV genome R-HSA-167172 6.775442e-01 0.169 0 0
Regulated Necrosis R-HSA-5218859 6.775442e-01 0.169 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.788564e-01 0.168 0 0
Signaling by SCF-KIT R-HSA-1433557 6.788564e-01 0.168 0 0
PPARA activates gene expression R-HSA-1989781 6.804585e-01 0.167 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.827906e-01 0.166 0 0
Glycogen synthesis R-HSA-3322077 6.827906e-01 0.166 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.827906e-01 0.166 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.827906e-01 0.166 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.827906e-01 0.166 0 0
Creatine metabolism R-HSA-71288 6.827906e-01 0.166 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.827906e-01 0.166 0 0
Protein hydroxylation R-HSA-9629569 6.827906e-01 0.166 0 0
Negative regulation of MET activity R-HSA-6807004 6.827906e-01 0.166 0 0
Nephrin family interactions R-HSA-373753 6.827906e-01 0.166 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 6.856412e-01 0.164 0 0
RMTs methylate histone arginines R-HSA-3214858 6.890754e-01 0.162 0 0
G1 Phase R-HSA-69236 6.890754e-01 0.162 0 0
Cyclin D associated events in G1 R-HSA-69231 6.890754e-01 0.162 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.917563e-01 0.160 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.943066e-01 0.158 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.943066e-01 0.158 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.970411e-01 0.157 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.970411e-01 0.157 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.970411e-01 0.157 0 0
Lagging Strand Synthesis R-HSA-69186 6.970411e-01 0.157 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.970411e-01 0.157 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.970411e-01 0.157 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 6.970411e-01 0.157 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.970411e-01 0.157 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.970411e-01 0.157 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.970411e-01 0.157 0 0
Disease R-HSA-1643685 6.984517e-01 0.156 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.990253e-01 0.156 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.990253e-01 0.156 0 0
DAG and IP3 signaling R-HSA-1489509 6.990253e-01 0.156 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.024375e-01 0.153 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.024375e-01 0.153 0 0
Interferon alpha/beta signaling R-HSA-909733 7.051643e-01 0.152 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.087097e-01 0.150 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.087097e-01 0.150 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.087097e-01 0.150 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.087097e-01 0.150 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.087097e-01 0.150 0 0
Diseases of DNA repair R-HSA-9675135 7.087097e-01 0.150 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.090585e-01 0.149 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.104026e-01 0.148 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.106522e-01 0.148 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.106522e-01 0.148 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.106522e-01 0.148 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.106522e-01 0.148 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.106522e-01 0.148 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 7.106522e-01 0.148 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.106522e-01 0.148 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.106522e-01 0.148 0 0
Signaling by Hedgehog R-HSA-5358351 7.147867e-01 0.146 0 0
Rab regulation of trafficking R-HSA-9007101 7.176235e-01 0.144 0 0
Mitochondrial biogenesis R-HSA-1592230 7.176235e-01 0.144 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.181324e-01 0.144 0 0
Synthesis of PC R-HSA-1483191 7.181324e-01 0.144 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 7.182027e-01 0.144 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.182027e-01 0.144 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.206884e-01 0.142 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.236526e-01 0.140 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.236526e-01 0.140 0 0
Fructose metabolism R-HSA-5652084 7.236526e-01 0.140 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.236526e-01 0.140 0 0
LDL clearance R-HSA-8964038 7.236526e-01 0.140 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.236526e-01 0.140 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.237112e-01 0.140 0 0
Infectious disease R-HSA-5663205 7.239800e-01 0.140 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.258388e-01 0.139 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.297043e-01 0.137 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.297323e-01 0.137 0 0
Telomere Maintenance R-HSA-157579 7.297323e-01 0.137 0 0
Biosynthesis of maresins R-HSA-9018682 7.360696e-01 0.133 0 0
Carnitine shuttle R-HSA-200425 7.360696e-01 0.133 0 0
Degradation of CDH1 R-HSA-9766229 7.362083e-01 0.133 0 0
UCH proteinases R-HSA-5689603 7.406240e-01 0.130 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.414074e-01 0.130 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 7.414074e-01 0.130 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.426312e-01 0.129 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.448701e-01 0.128 0 0
Azathioprine ADME R-HSA-9748787 7.448701e-01 0.128 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.477758e-01 0.126 0 0
CYP2E1 reactions R-HSA-211999 7.479294e-01 0.126 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.479294e-01 0.126 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.479294e-01 0.126 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.479294e-01 0.126 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.479294e-01 0.126 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 7.479294e-01 0.126 0 0
Complex III assembly R-HSA-9865881 7.479294e-01 0.126 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.479294e-01 0.126 0 0
PCP/CE pathway R-HSA-4086400 7.547690e-01 0.122 0 0
Integrin cell surface interactions R-HSA-216083 7.547690e-01 0.122 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.592570e-01 0.120 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.592570e-01 0.120 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.592570e-01 0.120 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.592570e-01 0.120 0 0
HDMs demethylate histones R-HSA-3214842 7.592570e-01 0.120 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.592570e-01 0.120 0 0
Laminin interactions R-HSA-3000157 7.592570e-01 0.120 0 0
PI Metabolism R-HSA-1483255 7.610943e-01 0.119 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.614632e-01 0.118 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.614632e-01 0.118 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.614632e-01 0.118 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.614632e-01 0.118 0 0
G1/S Transition R-HSA-69206 7.690251e-01 0.114 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.694037e-01 0.114 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.694037e-01 0.114 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.694037e-01 0.114 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.700762e-01 0.113 0 0
Metalloprotease DUBs R-HSA-5689901 7.700762e-01 0.113 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.700762e-01 0.113 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.700762e-01 0.113 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.700762e-01 0.113 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.700762e-01 0.113 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.700762e-01 0.113 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.771130e-01 0.110 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.785129e-01 0.109 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.785129e-01 0.109 0 0
RSV-host interactions R-HSA-9833110 7.785129e-01 0.109 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.804098e-01 0.108 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.804098e-01 0.108 0 0
Packaging Of Telomere Ends R-HSA-171306 7.804098e-01 0.108 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.804098e-01 0.108 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 7.804098e-01 0.108 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.804098e-01 0.108 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 7.804098e-01 0.108 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.804098e-01 0.108 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.804098e-01 0.108 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.804098e-01 0.108 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.845958e-01 0.105 0 0
G alpha (z) signalling events R-HSA-418597 7.845958e-01 0.105 0 0
Signaling by NOTCH3 R-HSA-9012852 7.845958e-01 0.105 0 0
Co-inhibition by PD-1 R-HSA-389948 7.861336e-01 0.105 0 0
HIV elongation arrest and recovery R-HSA-167287 7.902796e-01 0.102 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.902796e-01 0.102 0 0
Telomere Extension By Telomerase R-HSA-171319 7.902796e-01 0.102 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.902796e-01 0.102 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.902796e-01 0.102 0 0
Pyroptosis R-HSA-5620971 7.902796e-01 0.102 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.918570e-01 0.101 0 0
TNF signaling R-HSA-75893 7.918570e-01 0.101 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.934959e-01 0.100 0 0
Synthesis of PA R-HSA-1483166 7.989012e-01 0.098 0 0
Reproduction R-HSA-1474165 7.991357e-01 0.097 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.997063e-01 0.097 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.997063e-01 0.097 0 0
Death Receptor Signaling R-HSA-73887 8.002853e-01 0.097 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.057334e-01 0.094 0 0
Circadian clock R-HSA-9909396 8.084586e-01 0.092 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.087099e-01 0.092 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.087099e-01 0.092 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.087099e-01 0.092 0 0
DAP12 signaling R-HSA-2424491 8.087099e-01 0.092 0 0
Activation of BH3-only proteins R-HSA-114452 8.087099e-01 0.092 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.108683e-01 0.091 0 0
Extension of Telomeres R-HSA-180786 8.123584e-01 0.090 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.123584e-01 0.090 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.123584e-01 0.090 0 0
Leishmania infection R-HSA-9658195 8.141364e-01 0.089 0 0
Parasitic Infection Pathways R-HSA-9824443 8.141364e-01 0.089 0 0
Pyruvate metabolism R-HSA-70268 8.163782e-01 0.088 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.173092e-01 0.088 0 0
Budding and maturation of HIV virion R-HSA-162588 8.173092e-01 0.088 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.173092e-01 0.088 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.173092e-01 0.088 0 0
Aspartate and asparagine metabolism R-HSA-8963693 8.173092e-01 0.088 0 0
Downstream signal transduction R-HSA-186763 8.173092e-01 0.088 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.184468e-01 0.087 0 0
RAB geranylgeranylation R-HSA-8873719 8.187809e-01 0.087 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.187809e-01 0.087 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.247708e-01 0.084 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.255225e-01 0.083 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.255225e-01 0.083 0 0
ER-Phagosome pathway R-HSA-1236974 8.269896e-01 0.082 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.302614e-01 0.081 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.310378e-01 0.080 0 0
Signaling by PDGF R-HSA-186797 8.310378e-01 0.080 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.333670e-01 0.079 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.333670e-01 0.079 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.333670e-01 0.079 0 0
RNA Polymerase II Transcription R-HSA-73857 8.359820e-01 0.078 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.370718e-01 0.077 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.382986e-01 0.077 0 0
Ion channel transport R-HSA-983712 8.402314e-01 0.076 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.408593e-01 0.075 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.408593e-01 0.075 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.408593e-01 0.075 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.408593e-01 0.075 0 0
Glutamate and glutamine metabolism R-HSA-8964539 8.408593e-01 0.075 0 0
Ion transport by P-type ATPases R-HSA-936837 8.425423e-01 0.074 0 0
Signaling by Insulin receptor R-HSA-74752 8.466435e-01 0.072 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.480151e-01 0.072 0 0
Mitophagy R-HSA-5205647 8.480151e-01 0.072 0 0
eNOS activation R-HSA-203615 8.480151e-01 0.072 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.480151e-01 0.072 0 0
Signal amplification R-HSA-392518 8.480151e-01 0.072 0 0
RA biosynthesis pathway R-HSA-5365859 8.480151e-01 0.072 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.480151e-01 0.072 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.480151e-01 0.072 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.480151e-01 0.072 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.480151e-01 0.072 0 0
Post-translational protein modification R-HSA-597592 8.499732e-01 0.071 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.548496e-01 0.068 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.548496e-01 0.068 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 8.548496e-01 0.068 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.557231e-01 0.068 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.584699e-01 0.066 0 0
Kidney development R-HSA-9830369 8.584699e-01 0.066 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.600842e-01 0.065 0 0
GPVI-mediated activation cascade R-HSA-114604 8.613772e-01 0.065 0 0
RET signaling R-HSA-8853659 8.613772e-01 0.065 0 0
Signaling by WNT R-HSA-195721 8.629431e-01 0.064 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.633590e-01 0.064 0 0
Degradation of DVL R-HSA-4641258 8.676115e-01 0.062 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.676115e-01 0.062 0 0
Cleavage of the damaged purine R-HSA-110331 8.676115e-01 0.062 0 0
Metabolism of folate and pterines R-HSA-196757 8.676115e-01 0.062 0 0
COPII-mediated vesicle transport R-HSA-204005 8.729118e-01 0.059 0 0
tRNA processing in the mitochondrion R-HSA-6785470 8.735659e-01 0.059 0 0
Depurination R-HSA-73927 8.735659e-01 0.059 0 0
Elastic fibre formation R-HSA-1566948 8.735659e-01 0.059 0 0
MET promotes cell motility R-HSA-8875878 8.735659e-01 0.059 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.735659e-01 0.059 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.763921e-01 0.057 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.792528e-01 0.056 0 0
RAS processing R-HSA-9648002 8.792528e-01 0.056 0 0
Pentose phosphate pathway R-HSA-71336 8.792528e-01 0.056 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.792528e-01 0.056 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.792528e-01 0.056 0 0
Synthesis of bile acids and bile salts R-HSA-192105 8.801965e-01 0.055 0 0
Extracellular matrix organization R-HSA-1474244 8.809656e-01 0.055 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.839449e-01 0.054 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.839449e-01 0.054 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.839449e-01 0.054 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.846842e-01 0.053 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.846842e-01 0.053 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.846842e-01 0.053 0 0
HIV Transcription Elongation R-HSA-167169 8.846842e-01 0.053 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.846842e-01 0.053 0 0
Glycogen metabolism R-HSA-8982491 8.846842e-01 0.053 0 0
Diseases of Immune System R-HSA-5260271 8.846842e-01 0.053 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.846842e-01 0.053 0 0
rRNA processing in the mitochondrion R-HSA-8868766 8.846842e-01 0.053 0 0
Generation of second messenger molecules R-HSA-202433 8.846842e-01 0.053 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.846842e-01 0.053 0 0
Ca2+ pathway R-HSA-4086398 8.859861e-01 0.053 0 0
Generic Transcription Pathway R-HSA-212436 8.866137e-01 0.052 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.898717e-01 0.051 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.898717e-01 0.051 0 0
Maturation of spike protein R-HSA-9694548 8.898717e-01 0.051 0 0
Signaling by FGFR in disease R-HSA-1226099 8.900598e-01 0.051 0 0
Protein localization R-HSA-9609507 8.925643e-01 0.049 0 0
Protein ubiquitination R-HSA-8852135 8.939982e-01 0.049 0 0
Iron uptake and transport R-HSA-917937 8.939982e-01 0.049 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.939982e-01 0.049 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.948261e-01 0.048 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.948261e-01 0.048 0 0
Translation of Structural Proteins R-HSA-9683701 8.948261e-01 0.048 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.995578e-01 0.046 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.995578e-01 0.046 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.995578e-01 0.046 0 0
Depyrimidination R-HSA-73928 8.995578e-01 0.046 0 0
Translation of Structural Proteins R-HSA-9694635 9.014843e-01 0.045 0 0
Cardiac conduction R-HSA-5576891 9.050325e-01 0.043 0 0
Interleukin-10 signaling R-HSA-6783783 9.050396e-01 0.043 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.083931e-01 0.042 0 0
DAP12 interactions R-HSA-2172127 9.083931e-01 0.042 0 0
Netrin-1 signaling R-HSA-373752 9.083931e-01 0.042 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.125153e-01 0.040 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.125153e-01 0.040 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.125153e-01 0.040 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.125153e-01 0.040 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.128631e-01 0.040 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.149990e-01 0.039 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.164522e-01 0.038 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.164522e-01 0.038 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.164522e-01 0.038 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.164522e-01 0.038 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.164522e-01 0.038 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.183355e-01 0.037 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.210848e-01 0.036 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.238031e-01 0.034 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.272327e-01 0.033 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.272327e-01 0.033 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.294492e-01 0.032 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.305081e-01 0.031 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.305081e-01 0.031 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.306716e-01 0.031 0 0
Meiotic recombination R-HSA-912446 9.336363e-01 0.030 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.336363e-01 0.030 0 0
The phototransduction cascade R-HSA-2514856 9.336363e-01 0.030 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.351077e-01 0.029 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.366238e-01 0.028 0 0
Innate Immune System R-HSA-168249 9.391260e-01 0.027 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.394770e-01 0.027 0 0
Nucleotide biosynthesis R-HSA-8956320 9.394770e-01 0.027 0 0
Neurotransmitter release cycle R-HSA-112310 9.415561e-01 0.026 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.422019e-01 0.026 0 0
Paracetamol ADME R-HSA-9753281 9.448043e-01 0.025 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.478439e-01 0.023 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.478439e-01 0.023 0 0
G alpha (q) signalling events R-HSA-416476 9.483772e-01 0.023 0 0
Metabolism of nucleotides R-HSA-15869 9.486666e-01 0.023 0 0
IRS-mediated signalling R-HSA-112399 9.496633e-01 0.022 0 0
Dectin-2 family R-HSA-5621480 9.496633e-01 0.022 0 0
Mitochondrial protein degradation R-HSA-9837999 9.516719e-01 0.022 0 0
Collagen formation R-HSA-1474290 9.516719e-01 0.022 0 0
Metabolism of steroids R-HSA-8957322 9.536358e-01 0.021 0 0
tRNA Aminoacylation R-HSA-379724 9.561626e-01 0.019 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.561626e-01 0.019 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.581371e-01 0.019 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.581371e-01 0.019 0 0
Adaptive Immune System R-HSA-1280218 9.592313e-01 0.018 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.605278e-01 0.017 0 0
Complex I biogenesis R-HSA-6799198 9.618237e-01 0.017 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.618237e-01 0.017 0 0
Metabolism of proteins R-HSA-392499 9.621100e-01 0.017 0 0
Xenobiotics R-HSA-211981 9.635436e-01 0.016 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.635436e-01 0.016 0 0
IGF1R signaling cascade R-HSA-2428924 9.635436e-01 0.016 0 0
Interleukin-1 signaling R-HSA-9020702 9.644642e-01 0.016 0 0
Neddylation R-HSA-8951664 9.647846e-01 0.016 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.651861e-01 0.015 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.682526e-01 0.014 0 0
Integration of energy metabolism R-HSA-163685 9.713639e-01 0.013 0 0
Platelet homeostasis R-HSA-418346 9.718529e-01 0.012 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.723541e-01 0.012 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.723541e-01 0.012 0 0
ECM proteoglycans R-HSA-3000178 9.736001e-01 0.012 0 0
Hedgehog 'on' state R-HSA-5632684 9.736001e-01 0.012 0 0
Metal ion assimilation from the host R-HSA-9638482 9.736001e-01 0.012 0 0
Metabolism of cofactors R-HSA-8978934 9.736001e-01 0.012 0 0
Retinoid metabolism and transport R-HSA-975634 9.736001e-01 0.012 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.747582e-01 0.011 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.747900e-01 0.011 0 0
Purine catabolism R-HSA-74259 9.747900e-01 0.011 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.748281e-01 0.011 0 0
Aspirin ADME R-HSA-9749641 9.759264e-01 0.011 0 0
Phospholipid metabolism R-HSA-1483257 9.764645e-01 0.010 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.770116e-01 0.010 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.808852e-01 0.008 0 0
ABC transporter disorders R-HSA-5619084 9.808852e-01 0.008 0 0
Cholesterol biosynthesis R-HSA-191273 9.808852e-01 0.008 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.833563e-01 0.007 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.833563e-01 0.007 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.851879e-01 0.006 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.867862e-01 0.006 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.873823e-01 0.006 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.873823e-01 0.006 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.893035e-01 0.005 0 0
FCGR activation R-HSA-2029481 9.912794e-01 0.004 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.912794e-01 0.004 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.913227e-01 0.004 0 0
Scavenging of heme from plasma R-HSA-2168880 9.924079e-01 0.003 0 0
G alpha (s) signalling events R-HSA-418555 9.924461e-01 0.003 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.926006e-01 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.927506e-01 0.003 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.927506e-01 0.003 0 0
Regulation of insulin secretion R-HSA-422356 9.933905e-01 0.003 0 0
FOXO-mediated transcription R-HSA-9614085 9.936889e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.939739e-01 0.003 0 0
Respiratory electron transport R-HSA-611105 9.941750e-01 0.003 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.947541e-01 0.002 0 0
Peptide ligand-binding receptors R-HSA-375276 9.956832e-01 0.002 0 0
Visual phototransduction R-HSA-2187338 9.957192e-01 0.002 0 0
Gastrulation R-HSA-9758941 9.960561e-01 0.002 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.962147e-01 0.002 0 0
TCR signaling R-HSA-202403 9.963759e-01 0.002 0 0
Antimicrobial peptides R-HSA-6803157 9.965397e-01 0.002 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.967357e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.973783e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.975556e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.976339e-01 0.001 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.981894e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.982713e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.984955e-01 0.001 0 0
Bacterial Infection Pathways R-HSA-9824439 9.985022e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.985981e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.985981e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.986744e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.986906e-01 0.001 0 0
Drug ADME R-HSA-9748784 9.987779e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.991611e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.992133e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.994043e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.994313e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.995696e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.996076e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.996176e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.998043e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.998744e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999527e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999650e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999709e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999730e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999939e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999990e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999998e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways