TSSK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0MZ66	S473	Sugiyama	SHTN1 KIAA1598	LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss
A6NDS4	T152	Sugiyama	TBC1D3B TBC1D3I	KEKGKRSSEHIQRIDRDISGtLRKHMFFRDRYGTKQRELLH
A6NKT7	S980	Sugiyama	RGPD3 RGP3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
B9A6J9	T152	Sugiyama	TBC1D3L PRC17	KEKGKRSSEHIQRIDRDVSGtLRKHIFFRDRYGTKQRELLH
O00151	S84	Sugiyama	PDLIM1 CLIM1 CLP36	LEAQNRIKGCTDNLtLtVARsEHKVWsPLVtEEGKRHPYKM
O00231	S298	Sugiyama	PSMD11	RYAGRQTEALKCVAQASKNRsLADFEKALTDYRAELRDDPI
O00273	S28	Sugiyama	DFFA DFF1 DFF45 H13	GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00273	S302	Sugiyama	DFFA DFF1 DFF45 H13	TETVQEACERELALRLQQtQsLHsLRsIsAsKAsPPGDLQN
O00273	S37	Sugiyama	DFFA DFF1 DFF45 H13	TLKPCLLRRNysREQHGVAAsCLEDLRSKACDILAIDKSLT
O14715	S979	Sugiyama	RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15067	S215	Sugiyama	PFAS KIAA0361	LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15067	S225	Sugiyama	PFAS KIAA0361	KRFQELQRNPstVEAFDLAQsNsEHSRHWFFKGQLHVDGQK
O15226	T620	Sugiyama	NKRF ITBA4 NRF	KIAKRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQIA
O43464	S435	Sugiyama	HTRA2 OMI PRSS25	AIGEQMVQNAEDVYEAVRTQsQLAVQIRRGRETLTLYVTPE
O43823	S124	Sugiyama	AKAP8 AKAP95	SKEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHN
O43823	S323	Sugiyama	AKAP8 AKAP95	RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852	S69	Sugiyama	CALU	HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60447	S689	Sugiyama	EVI5 NB4S	AELEIQKEEGKLQGQLNKsDsNQYIGELKDQIAELNHELRC
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75122	S313	Sugiyama	CLASP2 KIAA0627	YNSLEPSYQKSLQTYLKssGsVAsLPQsDRsssssQEsLNR
O75128	S1171	Sugiyama	COBL KIAA0633	SALLAAIRGHSGTCSLRKVAsSAsEELQSFRDAALSAQGSE
O95155	S79	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	NMtPAtsPIGASGVAHRsQssEGVssLsssPsNsLEtQsQs
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95297	S260	Sugiyama	MPZL1 PZR UNQ849/PRO1787	IyAQLDHsGGHHSDKINKSEsVVyADIRKN___________
O95425	S228	Sugiyama	SVIL	GQELsATRQAHDLsPAAEsssTFsFSGRDssFtEVPRsPKH
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95757	S587	Sugiyama	HSPA4L APG1 HSPH3 OSP94	RLNQTLKKGKVKsIDLPIQssLCRQLGQDLLNsyIENEGKM
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	S319	Sugiyama	LDHA PIG19	GISDLVKVTLtsEEEARLKKsADtLWGIQKELQF_______
P00558	S174	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558	S175	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083	S189	Sugiyama	ANXA1 ANX1 LPC1	tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792	S187	Sugiyama	HSPB1 HSP27 HSP28	APMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAAK__
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455	S94	Sugiyama	SSB	KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787	S477	Sugiyama	KRT8 CYK8	SSRAVVVKKIETRDGKLVsEssDVLPK______________
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733	S349	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	AKAVNEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMV
P06733	S353	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs
P06744	S22	Sugiyama	GPI	AALTRDPQFQKLQQWyREHRsELNLRRLFDANKDRFNHFSL
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07384	S474	Sugiyama	CAPN1 CANPL1 PIG30	GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07602	S29	Sugiyama	PSAP GLBA SAP1	SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737	S57	Sugiyama	PFN1	GKtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDs
P07737	S58	Sugiyama	PFN1	KtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsL
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S399	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	S63	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08238	S391	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238	S58	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08670	S438	Sugiyama	VIM	FssLNLREtNLDsLPLVDtHsKRTLLIKtVEtRDGQVINEt
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P0CG47	S57	Sugiyama	UBB	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48	S57	Sugiyama	UBC	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0DJD0	S964	Sugiyama	RGPD1 RANBP2L6 RGP1	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7	S54	Sugiyama	TUBA3C TUBA2	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10809	S410	Sugiyama	HSPD1 HSP60	LNERLAKLsDGVAVLKVGGtsDVEVNEKKDRVtDALNAtRA
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11279	S141	Sugiyama	LAMP1	NLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSGTQV
P12004	S172	Sugiyama	PCNA	sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12956	S560	Sugiyama	XRCC6 G22P1	VtKRKHDNEGSGSKRPKVEysEEELKTHISKGTLGKFTVPM
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667	S470	Sugiyama	PDIA4 ERP70 ERP72	FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P13797	S339	Sugiyama	PLS3	PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13798	S187	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	EKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQFV
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625	S515	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14868	S192	Sugiyama	DARS1 DARS PIG40	ATVNQDTRLDNRVIDLRTsTsQAVFRLQSGICHLFRETLIN
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16949	S28	Sugiyama	STMN1 C1orf215 LAP18 OP18	VKELEKRAsGQAFELILsPRsKEsVPEFPLsPPKKKDLsLE
P16949	S38	Sugiyama	STMN1 C1orf215 LAP18 OP18	QAFELILsPRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAE
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544	S44	Sugiyama	ATF7 ATFA	LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17987	S374	Sugiyama	TCP1 CCT1 CCTA	ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18669	S14	Sugiyama	PGAM1 PGAMA CDABP0006	_______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P18669	S152	Sugiyama	PGAM1 PGAMA CDABP0006	FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P18754	S85	Sugiyama	RCC1 CHC1	IPEDVVQAEAGGMHTVCLSKsGQVysFGCNDEGALGRDtsV
P18858	S901	Sugiyama	LIG1	DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338	S328	Sugiyama	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20933	S59	Sugiyama	AGA	ATEAAWRALAsGGSALDAVEsGCAMCEREQCDGSVGFGGSP
P21108	S11	Sugiyama	PRPS1L1 PRPS3 PRPSL	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P21333	S1029	Sugiyama	FLNA FLN FLN1	VGPSGAAVPCKVEPGLGADNsVVRFLPREEGPYEVEVTYDG
P21333	S481	Sugiyama	FLNA FLN FLN1	AGVPIPRsPyTVtVGQACNPsACRAVGRGLQPKGVRVKETA
P22059	S240	Sugiyama	OSBP OSBP1	DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22059	S386	Sugiyama	OSBP OSBP1	ITMPENLGHKRtGsNIsGAssDIsLDEQyKHQLEETKKEKR
P22314	S46	Sugiyama	UBA1 A1S9T UBE1	AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P24534	S141	Sugiyama	EEF1B2 EEF1B EF1B	ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25705	S198	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P25789	S7	Sugiyama	PSMA4 HC9 PSC9	______________MSRRyDsRttIFsPEGRLYQVEYAMEA
P26038	S527	Sugiyama	MSN	ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038	T465	Sugiyama	MSN	WQQKAQMVQEDLEKTRAELKtAMstPHVAEPAENEQDEQDE
P26373	S106	Sugiyama	RPL13 BBC1 OK/SW-cl.46	IHKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLIL
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27348	S63	Sugiyama	YWHAQ	LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P29401	S105	Sugiyama	TKT	VWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGsL
P29966	S29	Sugiyama	MARCKS MACS PRKCSL	AAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAsPAA
P30041	S186	Sugiyama	PRDX6 AOP2 KIAA0106	SLQLTAEKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGV
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30622	S195	Sugiyama	CLIP1 CYLN1 RSN	AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG
P30622	S197	Sugiyama	CLIP1 CYLN1 RSN	KEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIGDR
P31327	S835	Sugiyama	CPS1	MCHPsIEGFTPRLPMNKEWPsNLDLRKELSEPSsTRIyAIA
P31943	S269	Sugiyama	HNRNPH1 HNRPH HNRPH1	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P31946	S65	Sugiyama	YWHAB	LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P31949	S35	Sugiyama	S100A11 MLN70 S100C	ESLIAVFQKYAGKDGyNytLsKtEFLsFMNTELAAFTKNQK
P33316	S120	Sugiyama	DUT	PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578	S365	Sugiyama	RPL4 RPL1	RNHKLRVDKAAAAAAALQAKsDEKAAVAGKKPVVGKKGKKA
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	S212	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P39748	S255	Sugiyama	FEN1 RAD2	CESIRGIGPKRAVDLIQKHKsIEEIVRRLDPNKYPVPENWL
P40925	S153	Sugiyama	MDH1 MDHA	ANtNCLtAsKSAPSIPKENFsCLtRLDHNRAKAQIALKLGV
P42566	S748	Sugiyama	EPS15 AF1P	STLSKVNNEDPFRSATSssVsNVVITKNVFEETSVKSEDEP
P42766	S29	Sugiyama	RPL35	LRGKKKEELLKQLDDLKVELsQLRVAKVTGGAASKLsKIRV
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013	S651	Sugiyama	MKI67	ISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLGAKQ
P46060	S454	Sugiyama	RANGAP1 KIAA1835 SD	VstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAFL
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P47712	S729	Sugiyama	PLA2G4A CPLA2 PLA2G4	KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49368	S458	Sugiyama	CCT3 CCTG TRIC5	RAVAQALEVIPRTLIQNCGAstIRLLtSLRAKHtQENCEtW
P49792	S1955	Sugiyama	RANBP2 NUP358	GVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSGAG
P50395	S270	Sugiyama	GDI2 RABGDIB	MLNKPIEEIIVQNGKVIGVKsEGEIARCKQLICDPSyVKDR
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50395	T425	Sugiyama	GDI2 RABGDIB	DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P50454	S138	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	LSNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEH
P50454	S139	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P50851	S1237	Sugiyama	LRBA BGL CDC4L LBA	NLTRETKLINDCHGsVSEAssEQKIAKLDVsNVAtDtERLE
P50990	S162	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	ILPNLVCCsAKNLRDIDEVssLLRTSIMSKQyGNEVFLAKL
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52943	S114	Sugiyama	CRIP2 CRP2	PAARAEERKAsGPPKGPsRAssVttFtGEPNtCPRCSKKVY
P52943	S115	Sugiyama	CRIP2 CRP2	AARAEERKAsGPPKGPsRAssVttFtGEPNtCPRCSKKVYF
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999	S17	Sugiyama	SUB1 PC4 RPO2TC1	____MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPV
P54105	S198	Sugiyama	CLNS1A CLCI ICLN	TAEGQATLERLEGMLsQsVssQYNMAGVRtEDsIRDyEDGM
P54105	S42	Sugiyama	CLNS1A CLCI ICLN	DTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGFSLEYPTIS
P54252	S260	Sugiyama	ATXN3 ATX3 MJD MJD1 SCA3	IDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNLTSEE
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55010	S10	Sugiyama	EIF5	___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P55011	S77	Sugiyama	SLC12A2 NKCC1	RDEGPAAAGDGLGRPLGPtPsQsRFQVDLVSENAGRAAAAA
P55036	S266	Sugiyama	PSMD4 MCB1	AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55060	S366	Sugiyama	CSE1L CAS XPO2	KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P55060	S931	Sugiyama	CSE1L CAS XPO2	KKEHDPVGQMVNNPKIHLAQsLHKLSTACPGRVPSMVSTSL
P55735	S184	Sugiyama	SEC13 D3S1231E SEC13A SEC13L1 SEC13R	PGsLIDHPSGQKPNYIKRFAsGGCDNLIKLWKEEEDGQWKE
P55795	S269	Sugiyama	HNRNPH2 FTP3 HNRPH2	YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P55854	S27	Sugiyama	SUMO3 SMT3A SMT3H1	KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P57721	S82	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P60174	S106	Sugiyama	TPI1 TPI	DCGAtWVVLGHsERRHVFGEsDELIGQKVAHALAEGLGVIA
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60891	S11	Sugiyama	PRPS1	__________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P60900	S175	Sugiyama	PSMA6 PROS27	DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P61221	Y594	Sugiyama	ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40	RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61313	S97	Sugiyama	RPL15 EC45 TCBAP0781	KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61956	S28	Sugiyama	SUMO2 SMT3B SMT3H2	EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P61981	S64	Sugiyama	YWHAG	LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62979	S57	Sugiyama	RPS27A UBA80 UBCEP1	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987	S57	Sugiyama	UBA52 UBCEP2	PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63241	S75	Sugiyama	EIF5A	KVHLVGIDIFTGKKyEDICPstHNMDVPNIKRNDFQLIGIQ
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363	S54	Sugiyama	TUBA1B	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P78371	S470	Sugiyama	CCT2 99D8.1 CCTB	IADNAGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAI
P78371	T474	Sugiyama	CCT2 99D8.1 CCTB	AGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAILGIT
P82094	S199	Sugiyama	TMF1 ARA160	ETVNKESDMKVPTVSLKVsEsVIDVKTTMESISNTstQsLT
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00587	S192	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q00587	S350	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	HyPEMDARQERVEVLPQARAsWEsLDEEWRAPQAGsRtPVP
Q00613	S375	Sugiyama	HSF1 HSTF1	TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q00688	T98	Sugiyama	FKBP3 FKBP25	ISKVSEQVKNVKLNEDKPKEtKsEEtLDEGPPKYTKSVLKK
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01082	S2184	Sugiyama	SPTBN1 SPTB2	ssPIPsPtsDRKAKTALPAQsAAtLPARtQEtPsAQMEGFL
Q01105	S63	Sugiyama	SET	EAIEHIDEVQNEIDRLNEQAsEEILKVEQKYNKLRQPFFQK
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01581	S404	Sugiyama	HMGCS1 HMGCS	YSLKVTQDATPGSALDKITAsLCDLKSRLDSRTGVAPDVFA
Q01970	S1041	Sugiyama	PLCB3	TKEGEDEAKRYQEFQNRQVQsLLELREAQVDAEAQRRLEHL
Q02878	S255	Sugiyama	RPL6 TXREB1	tEKEKYEITEQRKIDQKAVDsQILPKIKAIPQLQGYLRSVF
Q04637	S1238	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q04917	S64	Sugiyama	YWHAH YWHA1	LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q06210	T262	Sugiyama	GFPT1 GFAT GFPT	sQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDAS
Q09028	S146	Sugiyama	RBBP4 RBAP48	EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q13098	S483	Sugiyama	GPS1 COPS1 CSN1	QIHVKsPPREGsQGELtPANsQsRMstNM____________
Q13136	S338	Sugiyama	PPFIA1 LIP1	MEERITTLEKRYLAAQREATsVHDLNDKLENEIANKDSMHR
Q13136	S668	Sugiyama	PPFIA1 LIP1	EEKENTEQRAEEIESRVGsGsLDNLGRFRSMssIPPYPAss
Q13263	S473	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13283	S67	Sugiyama	G3BP1 G3BP	sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13428	S1230	Sugiyama	TCOF1	GLTPANSQASKAtPKLDssPsVsstLAAKDDPDGKQEAKPQ
Q13573	S182	Sugiyama	SNW1 SKIIP SKIP	AMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRVIRMVEM
Q13765	S186	Sugiyama	NACA HSD48	sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q14126	S551	Sugiyama	DSG2 CDHF5	FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14203	S31	Sugiyama	DCTN1	RTPSGSRMsAEASARPLRVGsRVEVIGKGHRGTVAYVGATL
Q14247	S345	Sugiyama	CTTN EMS1	EDVtQVssAyQKTVPVEAVtsKtsNIRANFENLAKEKEQED
Q14247	S348	Sugiyama	CTTN EMS1	tQVssAyQKTVPVEAVtsKtsNIRANFENLAKEKEQEDRRK
Q14432	S543	Sugiyama	PDE3A	ssPCssPLQGtPASSLVSKIsAVQFPEsADTTAKQSLGSHR
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14684	S392	Sugiyama	RRP1B KIAA0179	EKTNLEKEKGSRVFCVEEEDsEssLQKRRRKKKKKHHLQPE
Q14738	S598	Sugiyama	PPP2R5D	DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14C86	S902	Sugiyama	GAPVD1 GAPEX5 KIAA1521 RAP6	AEMEAFKQRHSYPERLVRsRssDIVSSVRRPMSDPSWNRRP
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15121	S116	Sugiyama	PEA15	DtKLtRIPsAKKYKDIIRQPsEEEIIKLAPPPKKA______
Q15172	S472	Sugiyama	PPP2R5A	EELWKKLEELKLKKALEKQNsAyNMHSILSNTSAE______
Q15185	S82	Sugiyama	PTGES3 P23 TEBP	NDsKHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVD
Q15276	S407	Sugiyama	RABEP1 RAB5EP RABPT5 RABPT5A	GDPFSKSDNDMFKDGLRRAQstDsLGtsGsLQSKALGYNYK
Q15293	S80	Sugiyama	RCN1 RCN	HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15365	S50	Sugiyama	PCBP1	GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15366	S50	Sugiyama	PCBP2	GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15398	S789	Sugiyama	DLGAP5 DLG7 KIAA0008	EKNTAsQNsILEEGEtKIsQsELFDNKsLttECHLLDsPGL
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15751	S1512	Sugiyama	HERC1	LtAESRLVHtsPNYRLIKsRsEsDLsQPEsDEEGYALsGRR
Q15751	S1514	Sugiyama	HERC1	AESRLVHtsPNYRLIKsRsEsDLsQPEsDEEGYALsGRRNV
Q15785	S93	Sugiyama	TOMM34 URCC3	DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q16576	S145	Sugiyama	RBBP7 RBAP46	EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q27J81	S1194	Sugiyama	INF2 C14orf151 C14orf173	EDEEDtAPEsALDtsLDKsFsEDAVtDssGsGtLPRARGRA
Q3MII6	S506	Sugiyama	TBC1D25 OATL1	DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q58FF6	S34	Sugiyama	HSP90AB4P	IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7	S58	Sugiyama	HSP90AB3P HSP90BC	IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8	S58	Sugiyama	HSP90AB2P HSP90BB	IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5JSH3	S565	Sugiyama	WDR44 RPH11	DYFNNMRMKYNtEGRVsPsPsQEsLsssKsDTDtGVCsGtD
Q5SW79	S865	Sugiyama	CEP170 FAM68A KAB KIAA0470	sPNIPIELIPHINKQTsstPssLALtsAsRIRERsEsLDPD
Q5T035	S66	Sugiyama	FAM120A2P C9orf129	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5T5U3	S1553	Sugiyama	ARHGAP21 ARHGAP10 KIAA1424	AQKSSHLEETGSDSGTLLSTsSQASLARFSMKKSTSPETKH
Q5T5Y3	S1398	Sugiyama	CAMSAP1	sCSDsGTKCSSTPDNLSRtQsGssLsLAsAAttEPESVHSG
Q5VT52	S1070	Sugiyama	RPRD2 KIAA0460 HSPC099	TATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETLGy
Q5VT52	S1177	Sugiyama	RPRD2 KIAA0460 HSPC099	GGLTGFKTAPYKERAPQFQEsVGsFRsNsFNstFEHHLPPs
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DHY5	T152	Sugiyama	TBC1D3G	KEKGKRSSEHIQRIDRDISGtLRKHMFFRDRYGTKQRELLH
Q6EEV6	S28	Sugiyama	SUMO4 SMT3H4	EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6GYQ0	S797	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM
Q6IPX1	T152	Sugiyama	TBC1D3C TBC1D3D	KEKGKRSSEHIQRIDRDVSGtLRKHIFFRDRYGTKQRELLH
Q6IS14	S75	Sugiyama	EIF5AL1	KVHLVGIDIFTGKKyEDICPstHNMDVPNIKRNDFQLIGIQ
Q6P996	S722	Sugiyama	PDXDC1 KIAA0251	PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2	S54	Sugiyama	TUBA3E	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6PID6	S19	Sugiyama	TTC33	__MASFGWKRKIGEKVSKVTsQQFEAEAADEKDVVDNDEGN
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36	S54	Sugiyama	TUBA1A TUBA3	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z3J3	S980	Sugiyama	RGPD4 RGP4	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
Q7Z3T8	S362	Sugiyama	ZFYVE16 KIAA0305	AQEDsKsLDLKDNDVIQDsSsALHVSSKDVPSSLSCLPASG
Q7Z460	S545	Sugiyama	CLASP1 KIAA0622 MAST1	yHTLESSyQKALQSHLKNSDsIVsLPQsDRsssssQEsLNR
Q7Z6B0	S139	Sugiyama	CCDC91 GGABP HSD8	VDDSEDPGANVSNIQLQQKIsSLEIKLKVSEEEKQRIKQDV
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V81	S239	Sugiyama	ALYREF ALY BEF THOC4	tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86X02	S318	Sugiyama	CDR2L HUMPPA	AQDGVssPAAsPGHVVRKsCsDTALNAIVAKDPASRHAGNL
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWZ3	S122	Sugiyama	ANKHD1 KIAA1085 MASK VBARP PP2500	EVEsFILDQEDLDNPVLKTTsEIFLSSTAEGADLRTVDPET
Q8IYB3	S240	Sugiyama	SRRM1 SRM160	tPELPEPsVKVKEPsVQEAtstsDILKVPKPEPIPEPKEPs
Q8IYB3	T239	Sugiyama	SRRM1 SRM160	KtPELPEPsVKVKEPsVQEAtstsDILKVPKPEPIPEPKEP
Q8N201	S495	Sugiyama	INTS1 KIAA1440 UNQ1821/PRO3434	KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N6T3	S345	Sugiyama	ARFGAP1 ARF1GAP	DQSFWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWE
Q8N806	S265	Sugiyama	UBR7 C14orf130	KDDVREVKVEQNsEPCAGsssEsDLQtVFKNESLNAESKSG
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBK3	S357	Sugiyama	SUMF1 PSEC0152 UNQ3037/PRO9852	HRSYCYRYRCAARSQNTPDSsAsNLGFRCAADRLPtMD___
Q8NBK3	S359	Sugiyama	SUMF1 PSEC0152 UNQ3037/PRO9852	SYCYRYRCAARSQNTPDSsAsNLGFRCAADRLPtMD_____
Q8NEZ2	S326	Sugiyama	VPS37A HCRP1	QMKSTFEKKMQRQHELSEsCsASALQARLKVAAHEAEEESD
Q8TDD1	S624	Sugiyama	DDX54	FQQGQQGRQEQQEGPVGPAPsRPALQEKQPEKEEEEEAGEs
Q8WWI1	S1510	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	RsAsVNKEPVSLPGIMRRGEsLDNLDsPRSNSWRQPPWLNQ
Q8WWI1	S704	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	KKRLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEM
Q8WWI1	S709	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	VERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQKIKS
Q8WWI1	T1425	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	KTEEAsSGFLPGDRNKsRsttELDDYSTNKNGNNKYLDQIG
Q8WXE0	S1154	Sugiyama	CASKIN2 KIAA1139	EsTGTVGPGQAQQRLEQTSSsLAAALRAAEKSIGTKEQEGT
Q8WXH0	S2781	Sugiyama	SYNE2 KIAA1011 NUA	ILSQIRKCKVTHDGILARQQsVEsLAEEVKDKVPSLTTYEG
Q92609	S541	Sugiyama	TBC1D5 KIAA0210	EsMPVQLNKGLSSKNIsssPsVEsLPGGREFtGsPPssAtK
Q92620	S438	Sugiyama	DHX38 DDX38 KIAA0224 PRP16	DGRIVFTKQPEPVIPVKDATsDLAIIARKGSQTVRKHREQK
Q96D15	S119	Sugiyama	RCN3 UNQ239/PRO272	LAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEELR
Q96D15	S76	Sugiyama	RCN3 UNQ239/PRO272	HEAFLGREVAKEFDQLtPEEsQARLGRIVDRMDRAGDGDGW
Q96EK9	T157	Sugiyama	KTI12 SBBI81	RAEEDGRAQAAGSSVLRELHtADSVVNGSAQADVPKELERE
Q96HE7	S145	Sugiyama	ERO1A ERO1L UNQ434/PRO865	NNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNF
Q96HE7	T148	Sugiyama	ERO1A ERO1L UNQ434/PRO865	IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q96IZ0	Y226	Sugiyama	PAWR PAR4	LLDPGSsyLLQEPPRTVSGRyKsttsVsEEDVsSRYsRTDR
Q96PF2	S153	Sugiyama	TSSK2 DGSG SPOGA2 STK22B	VHRDLKCENLLLDKDFNIKLsDFGFSKRCLRDSNGRIILSK
Q96PF2	S258	Sugiyama	TSSK2 DGSG SPOGA2 STK22B	SKNLTCECKDLIYRMLQPDVsQRLHIDEILSHSWLQPPKPK
Q96PF2	Y126	Sugiyama	TSSK2 DGSG SPOGA2 STK22B	GALHEDVARKMFRQLSSAVKyCHDLDIVHRDLKCENLLLDK
Q96PK6	S520	Sugiyama	RBM14 SIP	AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q99613	S754	Sugiyama	EIF3C EIF3S8	REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99614	S187	Sugiyama	TTC1 TPR1	KQDKKEMAINDCSKAIQLNPsyIRAILRRAELYEKTDKLDE
Q99618	S94	Sugiyama	CDCA3 C8 GRCC8 TOME1	ARtPMKTSsGDPPsPLVKQLsEVFETEDSKSNLPPEPVLPP
Q99666	S979	Sugiyama	RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
Q99700	T529	Sugiyama	ATXN2 ATX2 SCA2 TNRC13	GRQNsPRMGQPGsGSMPSRstsHtsDFNPNSGSDQRVVNGG
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3	S54	Sugiyama	TUBA1C TUBA6	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BRS2	S130	Sugiyama	RIOK1 RIO1	DKVLRKFENKINLDKLNVtDsVINKVTEKSRQKEADMYRIK
Q9BVS4	S412	Sugiyama	RIOK2 RIO2	EMTEFNQALEEIKGQVVENNsVTEFsEEKNRTENYNRQDGQ
Q9BXS6	S365	Sugiyama	NUSAP1 ANKT BM-037 PRO0310	EAtQtPVsNKKPVFDLKAsLsRPLNyEPHKGKLKPWGQSKE
Q9C0C2	S429	Sugiyama	TNKS1BP1 KIAA1741 TAB182	EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9GZV4	S75	Sugiyama	EIF5A2	KVHLVGIDIFTGKKyEDICPstHNMDVPNIKRNDYQLICIQ
Q9H2G2	S518	Sugiyama	SLK KIAA0204 STK2	tVDLVSQEtGEKEANIQAVDsEVGLTKEDtQEKLGEDDKTQ
Q9H3Q1	S315	Sugiyama	CDC42EP4 BORG4 CEP4	sARSMGSHTTRDSSsLssCtsGILEERsPAFRGPDRARAAV
Q9H6H4	S152	Sugiyama	REEP4 C8orf20 PP432	AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H788	S118	Sugiyama	SH2D4A PPP1R38 SH2A	IAERARLKAEQEAEEPRKTHsEEFTNsLKTKsQyHDLQAPD
Q9H7E2	S367	Sugiyama	TDRD3	LEGSGLPRNRGsERPSTssVsEVWAEDRIKCDRPYSRYDRT
Q9H7E9	T40	Sugiyama	C8orf33	PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9HCN8	S40	Sugiyama	SDF2L1 UNQ1941/PRO4424	ALLVPGGGAAKTGAELVTCGsVLKLLNTHHRVRLHSHDIKY
Q9HD42	S101	Sugiyama	CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1	TMKGVTKNMAQVTKALDKALsTMDLQKVSSVMDRFEQQVQN
Q9NP61	S429	Sugiyama	ARFGAP3 ARFGAP1	EPVENTDEAQKKFGNVKAIssDMyFGRQsQADYETRARLER
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NY61	S61	Sugiyama	AATF CHE1 DED HSPC277	DEGEDGEGDFLVVGsIRKLAsAsLLDtDKRYCGKTTSRKAW
Q9NYB9	S22	Sugiyama	ABI2 ARGBPIA	AELQMLLEEEIPGGRRALFDsytNLERVADyCENNyIQSAD
Q9NYL9	S25	Sugiyama	TMOD3	FRKDLEKyKDLDEDELLGNLsEtELKQLETVLDDLDPENAL
Q9NZB2	S417	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9UGP4	T265	Sugiyama	LIMD1	GGQNSGIGGRssEKPtGLWstASSQRVsPGLPsPNLENGAP
Q9UHX1	S461	Sugiyama	PUF60 FIR ROBPI SIAHBP1	sIsGssARHMVMQKLLRKQEsTVMVLRNMVDPKDIDDDLEG
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UKV3	T563	Sugiyama	ACIN1 ACINUS KIAA0670	TEECLKQPsLEQKEGRRAsHtLLPSHRLKQSADSSSSRSSS
Q9ULT8	S1395	Sugiyama	HECTD1 KIAA1131	AAGSSsRKGssssVCsVASSsDISLGSTKTERRSEIVMEHS
Q9UNF1	S85	Sugiyama	MAGED2 BCG1	KAtEVsKtPEAREAPAtQAssttQLtDtQVLAAENKSLAAD
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S2280	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	RtPAAAAAMNLAsPRtAVAPsAVNLADPRtPtAPAVNLAGA
Q9Y2B0	S116	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2B0	S74	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	GsFRINPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGE
Q9Y2B0	T79	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Q9Y2I7	S307	Sugiyama	PIKFYVE KIAA0981 PIP5K3	TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y3B8	S203	Sugiyama	REXO2 SFN SMFN CGI-114	EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Q9Y4K4	S335	Sugiyama	MAP4K5	AIIRHTIRSTNRNARAERtAsEINFDKLQFEPPLRKETEAR
Q9Y4X5	S514	Sugiyama	ARIH1 ARI MOP6 UBCH7BP HUSSY-27	NQADLENATEVLSGYLERDIsQDsLQDIKQKVQDKYRYCES
Q9Y6Y8	S894	Sugiyama	SEC23IP MSTP053	FISSLKSAWQTLNEFARAHtsstQLQEELEKVANQIKEEEE

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	3.566558e-11	10.448
Cell Cycle, Mitotic	R-HSA-69278	1.427525e-09	8.845
Mitotic Prometaphase	R-HSA-68877	4.194554e-08	7.377
Cell Cycle Checkpoints	R-HSA-69620	6.191741e-08	7.208
Signal Transduction	R-HSA-162582	1.304709e-07	6.884
M Phase	R-HSA-68886	2.169508e-07	6.664
Muscle contraction	R-HSA-397014	9.877560e-07	6.005
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.034375e-06	5.985
Apoptotic execution phase	R-HSA-75153	2.391022e-06	5.621
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.654163e-06	5.437
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	5.348309e-06	5.272
Mitotic G2-G2/M phases	R-HSA-453274	5.768355e-06	5.239
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	7.436669e-06	5.129
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	6.960240e-06	5.157
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	7.245103e-06	5.140
Mitotic Spindle Checkpoint	R-HSA-69618	9.247597e-06	5.034
Centrosome maturation	R-HSA-380287	1.182390e-05	4.927
Cellular response to heat stress	R-HSA-3371556	1.388700e-05	4.857
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.388700e-05	4.857
Cellular Senescence	R-HSA-2559583	1.352415e-05	4.869
NRAGE signals death through JNK	R-HSA-193648	1.451911e-05	4.838
G2/M Transition	R-HSA-69275	1.609809e-05	4.793
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.131557e-05	4.671
Amplification of signal from the kinetochores	R-HSA-141424	2.131557e-05	4.671
AURKA Activation by TPX2	R-HSA-8854518	2.432694e-05	4.614
HSF1-dependent transactivation	R-HSA-3371571	2.970840e-05	4.527
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.091824e-05	4.510
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.091824e-05	4.510
Separation of Sister Chromatids	R-HSA-2467813	6.364333e-05	4.196
Mitotic Anaphase	R-HSA-68882	6.850743e-05	4.164
Mitotic Metaphase and Anaphase	R-HSA-2555396	7.679645e-05	4.115
Striated Muscle Contraction	R-HSA-390522	8.227653e-05	4.085
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	8.655465e-05	4.063
Apoptosis	R-HSA-109581	9.170327e-05	4.038
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.020072e-04	3.991
Neurodegenerative Diseases	R-HSA-8863678	1.020072e-04	3.991
Chromatin modifying enzymes	R-HSA-3247509	1.645134e-04	3.784
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.733147e-04	3.761
Kinesins	R-HSA-983189	2.441989e-04	3.612
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.541751e-04	3.595
Chromatin organization	R-HSA-4839726	2.676187e-04	3.572
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.708562e-04	3.567
G alpha (12/13) signalling events	R-HSA-416482	2.860021e-04	3.544
Programmed Cell Death	R-HSA-5357801	3.181104e-04	3.497
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.471796e-04	3.459
Diseases of programmed cell death	R-HSA-9645723	4.100555e-04	3.387
Nervous system development	R-HSA-9675108	4.281945e-04	3.368
Oncogenic MAPK signaling	R-HSA-6802957	4.458254e-04	3.351
Semaphorin interactions	R-HSA-373755	4.466542e-04	3.350
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.727854e-04	3.325
Axon guidance	R-HSA-422475	4.804116e-04	3.318
Ion homeostasis	R-HSA-5578775	6.076862e-04	3.216
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	6.848923e-04	3.164
NGF-stimulated transcription	R-HSA-9031628	6.650426e-04	3.177
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	6.866527e-04	3.163
Post NMDA receptor activation events	R-HSA-438064	7.248639e-04	3.140
p75 NTR receptor-mediated signalling	R-HSA-193704	7.391278e-04	3.131
Selective autophagy	R-HSA-9663891	8.470339e-04	3.072
Membrane Trafficking	R-HSA-199991	1.053326e-03	2.977
Attenuation phase	R-HSA-3371568	1.416677e-03	2.849
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.380984e-03	2.860
HDMs demethylate histones	R-HSA-3214842	1.406948e-03	2.852
Aggrephagy	R-HSA-9646399	1.416677e-03	2.849
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.435015e-03	2.843
Autophagy	R-HSA-9612973	1.475006e-03	2.831
Cellular responses to stress	R-HSA-2262752	1.884921e-03	2.725
Death Receptor Signaling	R-HSA-73887	2.033930e-03	2.692
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.145366e-03	2.668
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	2.169659e-03	2.664
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.679127e-03	2.572
Signaling by AXIN mutants	R-HSA-4839735	2.734082e-03	2.563
Signaling by GSK3beta mutants	R-HSA-5339716	2.734082e-03	2.563
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.496440e-03	2.603
Signaling downstream of RAS mutants	R-HSA-9649948	2.496440e-03	2.603
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.496440e-03	2.603
Signaling by Hippo	R-HSA-2028269	2.728277e-03	2.564
Signaling by RAS mutants	R-HSA-6802949	2.496440e-03	2.603
Cellular responses to stimuli	R-HSA-8953897	2.717475e-03	2.566
Organelle biogenesis and maintenance	R-HSA-1852241	2.871852e-03	2.542
G2/M DNA damage checkpoint	R-HSA-69473	2.920569e-03	2.535
G0 and Early G1	R-HSA-1538133	3.033087e-03	2.518
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.123321e-03	2.505
G2/M Checkpoints	R-HSA-69481	3.588562e-03	2.445
Signaling by Interleukins	R-HSA-449147	3.409928e-03	2.467
Cilium Assembly	R-HSA-5617833	3.625831e-03	2.441
Chaperone Mediated Autophagy	R-HSA-9613829	3.715244e-03	2.430
Sema4D in semaphorin signaling	R-HSA-400685	3.961173e-03	2.402
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.950919e-03	2.403
Macroautophagy	R-HSA-1632852	3.900839e-03	2.409
Smooth Muscle Contraction	R-HSA-445355	3.975018e-03	2.401
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.011311e-03	2.397
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.011311e-03	2.397
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.011311e-03	2.397
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.011311e-03	2.397
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.011311e-03	2.397
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.677479e-03	2.330
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.677479e-03	2.330
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.965685e-03	2.304
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.002591e-03	2.301
Signaling by RAF1 mutants	R-HSA-9656223	5.064965e-03	2.295
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.800569e-03	2.319
Cardiac conduction	R-HSA-5576891	6.042494e-03	2.219
Transcriptional Regulation by TP53	R-HSA-3700989	6.063272e-03	2.217
Regulation of TP53 Activity	R-HSA-5633007	6.003344e-03	2.222
Meiotic recombination	R-HSA-912446	6.073516e-03	2.217
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.272217e-03	2.203
Regulation of CDH1 Gene Transcription	R-HSA-9764560	6.397663e-03	2.194
Signaling by APC mutants	R-HSA-4839744	6.895593e-03	2.161
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	6.895593e-03	2.161
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	6.895593e-03	2.161
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	6.895593e-03	2.161
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	6.524351e-03	2.185
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.524351e-03	2.185
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.524351e-03	2.185
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.524351e-03	2.185
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.524351e-03	2.185
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.577600e-03	2.182
Golgi-to-ER retrograde transport	R-HSA-8856688	6.673297e-03	2.176
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.529030e-03	2.185
Oxidative Stress Induced Senescence	R-HSA-2559580	7.060377e-03	2.151
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.952597e-03	2.099
Diseases of mitotic cell cycle	R-HSA-9675126	7.536110e-03	2.123
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.900840e-03	2.102
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.900840e-03	2.102
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	7.864502e-03	2.104
Signaling by ALK in cancer	R-HSA-9700206	7.864502e-03	2.104
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	8.054276e-03	2.094
DNA Double-Strand Break Repair	R-HSA-5693532	8.199782e-03	2.086
HSF1 activation	R-HSA-3371511	8.556193e-03	2.068
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	8.792602e-03	2.056
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	9.205488e-03	2.036
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.821848e-03	2.008
Signaling by AMER1 mutants	R-HSA-4839748	9.811895e-03	2.008
Beta-catenin phosphorylation cascade	R-HSA-196299	1.066501e-02	1.972
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.075632e-02	1.968
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.075632e-02	1.968
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.075632e-02	1.968
Calcineurin activates NFAT	R-HSA-2025928	1.194860e-02	1.923
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.201486e-02	1.920
Resolution of D-Loop Structures	R-HSA-5693537	1.115121e-02	1.953
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.115906e-02	1.952
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.194860e-02	1.923
Interleukin-37 signaling	R-HSA-9008059	1.201486e-02	1.920
Transcriptional regulation by RUNX1	R-HSA-8878171	1.224833e-02	1.912
Meiosis	R-HSA-1500620	1.248474e-02	1.904
Ub-specific processing proteases	R-HSA-5689880	1.252235e-02	1.902
Metalloprotease DUBs	R-HSA-5689901	1.282960e-02	1.892
RAF activation	R-HSA-5673000	1.340163e-02	1.873
Deubiquitination	R-HSA-5688426	1.348458e-02	1.870
Notch-HLH transcription pathway	R-HSA-350054	1.352789e-02	1.869
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.353843e-02	1.868
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.493385e-02	1.826
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.493385e-02	1.826
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.493385e-02	1.826
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.398553e-02	1.854
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.409319e-02	1.851
The NLRP3 inflammasome	R-HSA-844456	1.400408e-02	1.854
Transcriptional Regulation by E2F6	R-HSA-8953750	1.454039e-02	1.837
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.543954e-02	1.811
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.617737e-02	1.791
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.713206e-02	1.766
Homology Directed Repair	R-HSA-5693538	1.720683e-02	1.764
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.749941e-02	1.757
RMTs methylate histone arginines	R-HSA-3214858	1.801447e-02	1.744
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.818298e-02	1.740
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.818298e-02	1.740
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.826070e-02	1.738
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.847796e-02	1.733
EPH-Ephrin signaling	R-HSA-2682334	1.921422e-02	1.716
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.953225e-02	1.709
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	2.092727e-02	1.679
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	2.062909e-02	1.686
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	2.087400e-02	1.680
Signaling by NTRKs	R-HSA-166520	2.054101e-02	1.687
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.190071e-02	1.660
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.226839e-02	1.652
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.231082e-02	1.651
Platelet calcium homeostasis	R-HSA-418360	2.292959e-02	1.640
Late endosomal microautophagy	R-HSA-9615710	2.292959e-02	1.640
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.292959e-02	1.640
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.506894e-02	1.601
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.506894e-02	1.601
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.506894e-02	1.601
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.506894e-02	1.601
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.506894e-02	1.601
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.506894e-02	1.601
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.506894e-02	1.601
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.506894e-02	1.601
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.506894e-02	1.601
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.506894e-02	1.601
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.506894e-02	1.601
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.455720e-02	1.610
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.716544e-02	1.566
Long-term potentiation	R-HSA-9620244	2.505442e-02	1.601
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	2.505442e-02	1.601
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.455720e-02	1.610
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.716544e-02	1.566
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.733442e-02	1.563
Neurexins and neuroligins	R-HSA-6794361	2.804908e-02	1.552
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.979780e-02	1.526
Cell-extracellular matrix interactions	R-HSA-446353	3.061563e-02	1.514
Activation of RAC1	R-HSA-428540	3.116974e-02	1.506
Reduction of cytosolic Ca++ levels	R-HSA-418359	3.116974e-02	1.506
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.155401e-02	1.501
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.384659e-02	1.470
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.509455e-02	1.455
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.587584e-02	1.445
CLEC7A/inflammasome pathway	R-HSA-5660668	3.721306e-02	1.429
Lipophagy	R-HSA-9613354	4.072901e-02	1.390
Phosphorylation of the APC/C	R-HSA-176412	3.856895e-02	1.414
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.856895e-02	1.414
Phase 0 - rapid depolarisation	R-HSA-5576892	4.234993e-02	1.373
HDACs deacetylate histones	R-HSA-3214815	4.050322e-02	1.393
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.912468e-02	1.408
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.054569e-02	1.392
HATs acetylate histones	R-HSA-3214847	4.093381e-02	1.388
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.847292e-02	1.415
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	3.856895e-02	1.414
Signaling by WNT in cancer	R-HSA-4791275	3.787972e-02	1.422
Regulation of PTEN gene transcription	R-HSA-8943724	4.018710e-02	1.396
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.751191e-02	1.426
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.751191e-02	1.426
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.751191e-02	1.426
Intracellular signaling by second messengers	R-HSA-9006925	3.829049e-02	1.417
PKMTs methylate histone lysines	R-HSA-3214841	4.006519e-02	1.397
DNA Repair	R-HSA-73894	3.934333e-02	1.405
Inflammasomes	R-HSA-622312	4.234993e-02	1.373
Transcriptional Regulation by MECP2	R-HSA-8986944	4.334188e-02	1.363
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.374179e-02	1.359
Post-chaperonin tubulin folding pathway	R-HSA-389977	4.374179e-02	1.359
Nephrin family interactions	R-HSA-373753	4.374179e-02	1.359
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.410187e-02	1.356
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	4.410187e-02	1.356
Regulation of MECP2 expression and activity	R-HSA-9022692	4.410187e-02	1.356
Glycolysis	R-HSA-70171	4.458112e-02	1.351
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.518301e-02	1.345
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.691128e-02	1.329
DNA Double Strand Break Response	R-HSA-5693606	4.899384e-02	1.310
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	4.993438e-02	1.302
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	4.993438e-02	1.302
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.140059e-02	1.289
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.140059e-02	1.289
Formation of RNA Pol II elongation complex	R-HSA-112382	5.140065e-02	1.289
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.173411e-02	1.286
MTOR signalling	R-HSA-165159	5.197338e-02	1.284
mRNA Splicing - Major Pathway	R-HSA-72163	5.224586e-02	1.282
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.298963e-02	1.276
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	6.394485e-02	1.194
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.856946e-02	1.232
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.856946e-02	1.232
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.747076e-02	1.241
G1/S DNA Damage Checkpoints	R-HSA-69615	5.538566e-02	1.257
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.401898e-02	1.194
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	6.182767e-02	1.209
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	5.938258e-02	1.226
TBC/RABGAPs	R-HSA-8854214	5.875123e-02	1.231
MAPK family signaling cascades	R-HSA-5683057	6.215296e-02	1.207
Rab regulation of trafficking	R-HSA-9007101	5.943348e-02	1.226
Glucose metabolism	R-HSA-70326	5.943348e-02	1.226
Cell-Cell communication	R-HSA-1500931	5.770932e-02	1.239
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	5.825090e-02	1.235
TRP channels	R-HSA-3295583	6.507292e-02	1.187
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	6.507292e-02	1.187
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	6.507292e-02	1.187
Netrin-1 signaling	R-HSA-373752	6.609885e-02	1.180
Breakdown of the nuclear lamina	R-HSA-352238	7.966060e-02	1.099
Interactions of Tat with host cellular proteins	R-HSA-176034	7.966060e-02	1.099
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	7.966060e-02	1.099
TRIF-mediated programmed cell death	R-HSA-2562578	7.185400e-02	1.144
ChREBP activates metabolic gene expression	R-HSA-163765	6.902766e-02	1.161
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.813215e-02	1.107
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	7.813215e-02	1.107
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	7.004936e-02	1.155
Ephrin signaling	R-HSA-3928664	7.004936e-02	1.155
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.356607e-02	1.133
Packaging Of Telomere Ends	R-HSA-171306	7.537307e-02	1.123
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	6.639449e-02	1.178
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	7.864408e-02	1.104
mRNA Splicing	R-HSA-72172	7.003520e-02	1.155
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.685589e-02	1.175
TCF dependent signaling in response to WNT	R-HSA-201681	7.375820e-02	1.132
Processing of DNA double-strand break ends	R-HSA-5693607	6.747933e-02	1.171
Polo-like kinase mediated events	R-HSA-156711	7.004936e-02	1.155
RET signaling	R-HSA-8853659	7.586377e-02	1.120
Mitotic Prophase	R-HSA-68875	7.339902e-02	1.134
Activation of PUMA and translocation to mitochondria	R-HSA-139915	7.185400e-02	1.144
CaM pathway	R-HSA-111997	7.586377e-02	1.120
Calmodulin induced events	R-HSA-111933	7.586377e-02	1.120
MyD88-independent TLR4 cascade	R-HSA-166166	6.890373e-02	1.162
FLT3 signaling through SRC family kinases	R-HSA-9706374	6.772770e-02	1.169
DAG and IP3 signaling	R-HSA-1489509	7.402813e-02	1.131
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.890373e-02	1.162
MAP kinase activation	R-HSA-450294	7.639359e-02	1.117
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.103923e-02	1.149
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	7.266755e-02	1.139
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.855688e-02	1.105
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.122130e-02	1.147
Transcriptional Regulation by VENTX	R-HSA-8853884	7.514459e-02	1.124
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.402813e-02	1.131
MECP2 regulates transcription factors	R-HSA-9022707	7.185400e-02	1.144
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	7.601991e-02	1.119
Cytokine Signaling in Immune system	R-HSA-1280215	7.876183e-02	1.104
Transport of connexons to the plasma membrane	R-HSA-190872	7.004936e-02	1.155
Interleukin-12 signaling	R-HSA-9020591	6.970132e-02	1.157
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.994490e-02	1.097
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.994490e-02	1.097
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.128220e-02	1.090
Rap1 signalling	R-HSA-392517	8.316960e-02	1.080
Maturation of nucleoprotein	R-HSA-9694631	8.316960e-02	1.080
Heme signaling	R-HSA-9707616	8.393344e-02	1.076
MAP2K and MAPK activation	R-HSA-5674135	8.424241e-02	1.074
Negative regulation of MAPK pathway	R-HSA-5675221	8.424241e-02	1.074
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.509114e-02	1.070
Cell junction organization	R-HSA-446728	8.545128e-02	1.068
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	8.569952e-02	1.067
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	8.638952e-02	1.064
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	8.647001e-02	1.063
Transport of the SLBP independent Mature mRNA	R-HSA-159227	8.647001e-02	1.063
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.647001e-02	1.063
Regulation of necroptotic cell death	R-HSA-5675482	8.647001e-02	1.063
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.647001e-02	1.063
Activation of ATR in response to replication stress	R-HSA-176187	8.647001e-02	1.063
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.657283e-02	1.063
Nuclear Envelope Breakdown	R-HSA-2980766	8.657283e-02	1.063
RNA Polymerase I Promoter Escape	R-HSA-73772	8.916569e-02	1.050
Recycling pathway of L1	R-HSA-437239	9.166367e-02	1.038
Regulation by c-FLIP	R-HSA-3371378	9.367089e-02	1.028
Dimerization of procaspase-8	R-HSA-69416	9.367089e-02	1.028
MET receptor recycling	R-HSA-8875656	9.367089e-02	1.028
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	9.413779e-02	1.026
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	9.637215e-02	1.016
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	9.637215e-02	1.016
G2 Phase	R-HSA-68911	9.637215e-02	1.016
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.182232e-01	0.927
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	1.182232e-01	0.927
CASP8 activity is inhibited	R-HSA-5218900	1.182232e-01	0.927
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.058087e-01	0.975
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.113388e-01	0.953
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.133196e-01	0.946
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	9.880751e-02	1.005
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	9.774669e-02	1.010
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.072774e-01	0.969
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.072774e-01	0.969
Meiotic synapsis	R-HSA-1221632	9.825129e-02	1.008
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.825129e-02	1.008
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.031685e-01	0.986
G1/S Transition	R-HSA-69206	1.077548e-01	0.968
Cyclin E associated events during G1/S transition	R-HSA-69202	1.051887e-01	0.978
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.058087e-01	0.975
EPHB-mediated forward signaling	R-HSA-3928662	1.154853e-01	0.937
Regulation of mitotic cell cycle	R-HSA-453276	1.140283e-01	0.943
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.140283e-01	0.943
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.182232e-01	0.927
Activation of BH3-only proteins	R-HSA-114452	1.119319e-01	0.951
UCH proteinases	R-HSA-5689603	1.094964e-01	0.961
PIP3 activates AKT signaling	R-HSA-1257604	1.059856e-01	0.975
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.113388e-01	0.953
Estrogen-dependent gene expression	R-HSA-9018519	1.177156e-01	0.929
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.136413e-01	0.944
PI Metabolism	R-HSA-1483255	1.177723e-01	0.929
Reproduction	R-HSA-1474165	1.095794e-01	0.960
Signaling by ALK	R-HSA-201556	1.072774e-01	0.969
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.182232e-01	0.927
PKR-mediated signaling	R-HSA-9833482	9.730084e-02	1.012
Interleukin-12 family signaling	R-HSA-447115	1.169032e-01	0.932
HIV Transcription Elongation	R-HSA-167169	1.192069e-01	0.924
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.192069e-01	0.924
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.192069e-01	0.924
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.192069e-01	0.924
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.227545e-01	0.911
Oncogene Induced Senescence	R-HSA-2559585	1.227545e-01	0.911
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.265178e-01	0.898
S Phase	R-HSA-69242	1.271091e-01	0.896
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.271700e-01	0.896
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.271700e-01	0.896
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.271700e-01	0.896
Maturation of nucleoprotein	R-HSA-9683610	1.271700e-01	0.896
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.272046e-01	0.895
Nucleosome assembly	R-HSA-774815	1.272046e-01	0.895
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.283014e-01	0.892
Regulation of TP53 Expression	R-HSA-6804754	1.283515e-01	0.892
DSCAM interactions	R-HSA-376172	1.283515e-01	0.892
Regulation of cortical dendrite branching	R-HSA-8985801	1.283515e-01	0.892
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	1.283515e-01	0.892
Assembly of the pre-replicative complex	R-HSA-68867	1.284699e-01	0.891
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.287816e-01	0.890
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.287816e-01	0.890
TRAIL signaling	R-HSA-75158	1.290416e-01	0.889
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.290416e-01	0.889
IkBA variant leads to EDA-ID	R-HSA-5603029	1.290416e-01	0.889
Signaling by MAPK mutants	R-HSA-9652817	1.290416e-01	0.889
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.290416e-01	0.889
CDC6 association with the ORC:origin complex	R-HSA-68689	1.290416e-01	0.889
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.309998e-01	0.883
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.434844e-01	0.843
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.434844e-01	0.843
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.434844e-01	0.843
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.434844e-01	0.843
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.434844e-01	0.843
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.649896e-01	0.783
CREB phosphorylation	R-HSA-199920	1.649896e-01	0.783
G2/M DNA replication checkpoint	R-HSA-69478	1.649896e-01	0.783
Regulation of the apoptosome activity	R-HSA-9627069	1.452327e-01	0.838
MET activates RAP1 and RAC1	R-HSA-8875555	1.452327e-01	0.838
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.743786e-01	0.759
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.743786e-01	0.759
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.503244e-01	0.823
DCC mediated attractive signaling	R-HSA-418885	1.750963e-01	0.757
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.505754e-01	0.822
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.722204e-01	0.764
EPHA-mediated growth cone collapse	R-HSA-3928663	1.450052e-01	0.839
RNA Polymerase I Promoter Opening	R-HSA-73728	1.450052e-01	0.839
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.587690e-01	0.799
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.330064e-01	0.876
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.497253e-01	0.825
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.678769e-01	0.775
Neutrophil degranulation	R-HSA-6798695	1.587308e-01	0.799
Hedgehog 'off' state	R-HSA-5610787	1.487217e-01	0.828
Formation of apoptosome	R-HSA-111458	1.452327e-01	0.838
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	1.452327e-01	0.838
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.609451e-01	0.793
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	1.503244e-01	0.823
Response of endothelial cells to shear stress	R-HSA-9860931	1.337487e-01	0.874
Interleukin-2 signaling	R-HSA-9020558	1.743786e-01	0.759
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.318502e-01	0.880
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.661399e-01	0.780
Signaling by WNT	R-HSA-195721	1.486737e-01	0.828
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.358000e-01	0.867
Effects of PIP2 hydrolysis	R-HSA-114508	1.733039e-01	0.761
mTORC1-mediated signalling	R-HSA-166208	1.484245e-01	0.828
E2F mediated regulation of DNA replication	R-HSA-113510	1.722204e-01	0.764
Signaling by FGFR1 in disease	R-HSA-5655302	1.451906e-01	0.838
NoRC negatively regulates rRNA expression	R-HSA-427413	1.725957e-01	0.763
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.399395e-01	0.854
Ca-dependent events	R-HSA-111996	1.592068e-01	0.798
Signaling by ROBO receptors	R-HSA-376176	1.470958e-01	0.832
Protein-protein interactions at synapses	R-HSA-6794362	1.403745e-01	0.853
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.399395e-01	0.854
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.649026e-01	0.783
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.649026e-01	0.783
Generic Transcription Pathway	R-HSA-212436	1.423797e-01	0.847
Formation of the anterior neural plate	R-HSA-9823739	1.750963e-01	0.757
Protein methylation	R-HSA-8876725	1.750963e-01	0.757
Interleukin-17 signaling	R-HSA-448424	1.609451e-01	0.793
RAF/MAP kinase cascade	R-HSA-5673001	1.332751e-01	0.875
p75NTR signals via NF-kB	R-HSA-193639	1.750963e-01	0.757
Vesicle-mediated transport	R-HSA-5653656	1.570871e-01	0.804
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.566986e-01	0.805
Nef and signal transduction	R-HSA-164944	1.649896e-01	0.783
MAPK1/MAPK3 signaling	R-HSA-5684996	1.383201e-01	0.859
Cleavage of the damaged purine	R-HSA-110331	1.509283e-01	0.821
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	1.452069e-01	0.838
Depurination	R-HSA-73927	1.661399e-01	0.780
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.725957e-01	0.763
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.505754e-01	0.822
Mitochondrial biogenesis	R-HSA-1592230	1.724476e-01	0.763
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.505754e-01	0.822
Diseases of DNA repair	R-HSA-9675135	1.395607e-01	0.855
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.768652e-01	0.752
Clathrin-mediated endocytosis	R-HSA-8856828	1.774963e-01	0.751
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.802750e-01	0.744
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.802750e-01	0.744
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.802750e-01	0.744
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.805688e-01	0.743
DNA methylation	R-HSA-5334118	1.806286e-01	0.743
MET interacts with TNS proteins	R-HSA-8875513	1.820205e-01	0.740
MET activates PTPN11	R-HSA-8865999	1.820205e-01	0.740
FasL/ CD95L signaling	R-HSA-75157	1.820205e-01	0.740
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.820205e-01	0.740
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.820205e-01	0.740
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.663881e-01	0.574
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.663881e-01	0.574
Diseases of Telomere Maintenance	R-HSA-9673013	2.663881e-01	0.574
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.663881e-01	0.574
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.663881e-01	0.574
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.663881e-01	0.574
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.663881e-01	0.574
TICAM1 deficiency - HSE	R-HSA-5602566	2.663881e-01	0.574
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.663881e-01	0.574
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.663881e-01	0.574
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.663881e-01	0.574
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.663881e-01	0.574
TNFR1-mediated ceramide production	R-HSA-5626978	2.382378e-01	0.623
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.382378e-01	0.623
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.382378e-01	0.623
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.382378e-01	0.623
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.716621e-01	0.430
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	3.716621e-01	0.430
Mitochondrial transcription initiation	R-HSA-163282	3.716621e-01	0.430
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.716621e-01	0.430
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.716621e-01	0.430
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.716621e-01	0.430
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.716621e-01	0.430
Signaling by TCF7L2 mutants	R-HSA-5339700	3.716621e-01	0.430
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.716621e-01	0.430
TRAF3 deficiency - HSE	R-HSA-5602571	3.716621e-01	0.430
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.716621e-01	0.430
Intestinal infectious diseases	R-HSA-8942233	3.716621e-01	0.430
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.716621e-01	0.430
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.716621e-01	0.430
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.716621e-01	0.430
MyD88 deficiency (TLR5)	R-HSA-5602680	3.716621e-01	0.430
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.716621e-01	0.430
RUNX3 regulates WNT signaling	R-HSA-8951430	2.034580e-01	0.692
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.034580e-01	0.692
SOS-mediated signalling	R-HSA-112412	2.034580e-01	0.692
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.034580e-01	0.692
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.951683e-01	0.530
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.951683e-01	0.530
IRS activation	R-HSA-74713	2.951683e-01	0.530
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.951683e-01	0.530
NOSIP mediated eNOS trafficking	R-HSA-203754	2.951683e-01	0.530
Type I hemidesmosome assembly	R-HSA-446107	2.437159e-01	0.613
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.437159e-01	0.613
Signaling by MRAS-complex mutants	R-HSA-9660537	2.437159e-01	0.613
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.437159e-01	0.613
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.053153e-01	0.688
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.053153e-01	0.688
ERKs are inactivated	R-HSA-202670	2.053153e-01	0.688
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	2.012904e-01	0.696
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.012904e-01	0.696
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.376865e-01	0.624
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.376865e-01	0.624
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.376865e-01	0.624
Interleukin-21 signaling	R-HSA-9020958	2.850853e-01	0.545
WNT mediated activation of DVL	R-HSA-201688	2.850853e-01	0.545
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.514503e-01	0.454
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	3.514503e-01	0.454
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.514503e-01	0.454
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.514503e-01	0.454
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.514503e-01	0.454
Phosphorylation of Emi1	R-HSA-176417	3.514503e-01	0.454
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.514503e-01	0.454
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.514503e-01	0.454
Signalling to ERK5	R-HSA-198765	4.618343e-01	0.336
TWIK related potassium channel (TREK)	R-HSA-1299503	4.618343e-01	0.336
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.618343e-01	0.336
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.618343e-01	0.336
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.618343e-01	0.336
Potassium transport channels	R-HSA-1296067	4.618343e-01	0.336
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	4.618343e-01	0.336
Essential pentosuria	R-HSA-5662853	4.618343e-01	0.336
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.618343e-01	0.336
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.618343e-01	0.336
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.286980e-01	0.641
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.286980e-01	0.641
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.286980e-01	0.641
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	2.711372e-01	0.567
Formation of axial mesoderm	R-HSA-9796292	2.711372e-01	0.567
TRAF6 mediated NF-kB activation	R-HSA-933542	1.879736e-01	0.726
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.189527e-01	0.660
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	3.269557e-01	0.486
Folding of actin by CCT/TriC	R-HSA-390450	3.269557e-01	0.486
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.571032e-01	0.590
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.571032e-01	0.590
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.571032e-01	0.590
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.571032e-01	0.590
SWI/SNF chromatin remodelers	R-HSA-9932451	2.092040e-01	0.679
ATP-dependent chromatin remodelers	R-HSA-9932444	2.092040e-01	0.679
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.997423e-01	0.700
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.053238e-01	0.515
Neurofascin interactions	R-HSA-447043	4.060982e-01	0.391
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	4.060982e-01	0.391
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	4.060982e-01	0.391
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.906807e-01	0.720
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.862882e-01	0.543
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.196305e-01	0.658
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.196305e-01	0.658
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.087741e-01	0.680
FGFR2 alternative splicing	R-HSA-6803529	2.693397e-01	0.570
Formation of the posterior neural plate	R-HSA-9832991	3.687918e-01	0.433
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.986385e-01	0.702
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.540805e-01	0.595
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.540805e-01	0.595
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.540805e-01	0.595
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.399211e-01	0.469
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.856214e-01	0.731
Telomere Extension By Telomerase	R-HSA-171319	2.775121e-01	0.557
HIV elongation arrest and recovery	R-HSA-167287	2.775121e-01	0.557
Pausing and recovery of HIV elongation	R-HSA-167290	2.775121e-01	0.557
Integrin signaling	R-HSA-354192	2.614174e-01	0.583
IPs transport between nucleus and cytosol	R-HSA-1855170	2.614174e-01	0.583
Condensation of Prophase Chromosomes	R-HSA-2299718	2.214507e-01	0.655
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.259458e-01	0.646
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.831498e-01	0.548
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.831498e-01	0.548
Deadenylation of mRNA	R-HSA-429947	3.221935e-01	0.492
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.461441e-01	0.461
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	3.746277e-01	0.426
Phase 4 - resting membrane potential	R-HSA-5576886	3.746277e-01	0.426
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.101357e-01	0.387
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.101357e-01	0.387
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	4.584222e-01	0.339
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.584222e-01	0.339
MET activates PI3K/AKT signaling	R-HSA-8851907	4.584222e-01	0.339
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.584222e-01	0.339
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	4.584222e-01	0.339
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	4.584222e-01	0.339
Cohesin Loading onto Chromatin	R-HSA-2470946	4.584222e-01	0.339
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.584222e-01	0.339
The IPAF inflammasome	R-HSA-844623	5.390705e-01	0.268
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	5.390705e-01	0.268
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	5.390705e-01	0.268
Phenylketonuria	R-HSA-2160456	5.390705e-01	0.268
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.390705e-01	0.268
Defective ABCC2 causes DJS	R-HSA-5679001	5.390705e-01	0.268
Classical Kir channels	R-HSA-1296053	5.390705e-01	0.268
Defective CYP7B1 causes SPG5A and CBAS3	R-HSA-5579013	5.390705e-01	0.268
Defective GCLC causes HAGGSD	R-HSA-5578999	5.390705e-01	0.268
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.390705e-01	0.268
Defective CYP1B1 causes Glaucoma	R-HSA-5579000	5.390705e-01	0.268
Invadopodia formation	R-HSA-8941237	5.390705e-01	0.268
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.390705e-01	0.268
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.421281e-01	0.616
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.258067e-01	0.487
Activation of the pre-replicative complex	R-HSA-68962	3.258067e-01	0.487
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.258067e-01	0.487
snRNP Assembly	R-HSA-191859	2.450908e-01	0.611
Metabolism of non-coding RNA	R-HSA-194441	2.450908e-01	0.611
Tight junction interactions	R-HSA-420029	3.491727e-01	0.457
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.764083e-01	0.424
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.764083e-01	0.424
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	3.764083e-01	0.424
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.367945e-01	0.626
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	4.091695e-01	0.388
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.639865e-01	0.578
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	3.763282e-01	0.424
MET activates RAS signaling	R-HSA-8851805	4.506047e-01	0.346
G1/S-Specific Transcription	R-HSA-69205	3.506639e-01	0.455
PRC2 methylates histones and DNA	R-HSA-212300	3.506639e-01	0.455
Orc1 removal from chromatin	R-HSA-68949	3.290652e-01	0.483
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	3.492954e-01	0.457
Voltage gated Potassium channels	R-HSA-1296072	3.736507e-01	0.428
Cristae formation	R-HSA-8949613	4.035235e-01	0.394
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.433023e-01	0.353
ROBO receptors bind AKAP5	R-HSA-9010642	5.079641e-01	0.294
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	5.079641e-01	0.294
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.480745e-01	0.458
Eukaryotic Translation Elongation	R-HSA-156842	3.215267e-01	0.493
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.306296e-01	0.366
Formation of the Early Elongation Complex	R-HSA-113418	4.306296e-01	0.366
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.898877e-01	0.310
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.169295e-01	0.499
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.250440e-01	0.372
PKA activation in glucagon signalling	R-HSA-164378	4.768121e-01	0.322
Signaling by Erythropoietin	R-HSA-9006335	4.575265e-01	0.340
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.575265e-01	0.340
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	4.498004e-01	0.347
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.365828e-01	0.360
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.365828e-01	0.360
Chaperonin-mediated protein folding	R-HSA-390466	4.183801e-01	0.378
mRNA 3'-end processing	R-HSA-72187	4.511652e-01	0.346
mRNA Splicing - Minor Pathway	R-HSA-72165	4.581282e-01	0.339
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	4.581282e-01	0.339
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.657894e-01	0.332
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.955414e-01	0.305
Regulation of signaling by CBL	R-HSA-912631	5.095154e-01	0.293
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.277393e-01	0.278
cGMP effects	R-HSA-418457	5.277393e-01	0.278
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.884914e-01	0.311
HCMV Early Events	R-HSA-9609690	4.064941e-01	0.391
Nuclear Receptor transcription pathway	R-HSA-383280	4.621300e-01	0.335
Vif-mediated degradation of APOBEC3G	R-HSA-180585	4.986029e-01	0.302
TGFBR3 expression	R-HSA-9839394	5.241033e-01	0.281
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.109231e-01	0.292
Co-inhibition by CTLA4	R-HSA-389513	5.412581e-01	0.267
Regulation of endogenous retroelements	R-HSA-9842860	4.842877e-01	0.315
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.976531e-01	0.303
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.925752e-01	0.308
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	5.359068e-01	0.271
Peptide chain elongation	R-HSA-156902	5.370335e-01	0.270
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	5.478737e-01	0.261
FOXO-mediated transcription	R-HSA-9614085	3.480695e-01	0.458
Co-inhibition by PD-1	R-HSA-389948	2.622065e-01	0.581
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.017234e-01	0.695
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.017234e-01	0.695
Nucleotide Excision Repair	R-HSA-5696398	2.784223e-01	0.555
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.667547e-01	0.574
Specification of the neural plate border	R-HSA-9834899	3.160379e-01	0.500
RNA Polymerase I Transcription	R-HSA-73864	2.649071e-01	0.577
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.017234e-01	0.695
Platelet Aggregation (Plug Formation)	R-HSA-76009	4.365828e-01	0.360
Interleukin-9 signaling	R-HSA-8985947	2.437159e-01	0.613
Chromosome Maintenance	R-HSA-73886	4.343488e-01	0.362
Cytochrome c-mediated apoptotic response	R-HSA-111461	2.053153e-01	0.688
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.955333e-01	0.529
DARPP-32 events	R-HSA-180024	3.014582e-01	0.521
Telomere Maintenance	R-HSA-157579	4.096047e-01	0.388
Germ layer formation at gastrulation	R-HSA-9754189	3.160379e-01	0.500
Switching of origins to a post-replicative state	R-HSA-69052	1.971352e-01	0.705
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.904058e-01	0.720
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	3.062548e-01	0.514
Protein folding	R-HSA-391251	4.138958e-01	0.383
Epigenetic regulation of gene expression	R-HSA-212165	2.249192e-01	0.648
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	2.034580e-01	0.692
Sensing of DNA Double Strand Breaks	R-HSA-5693548	2.053153e-01	0.688
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	3.746277e-01	0.426
Killing mechanisms	R-HSA-9664420	3.746277e-01	0.426
Transcriptional regulation of testis differentiation	R-HSA-9690406	4.091695e-01	0.388
Interleukin-2 family signaling	R-HSA-451927	3.078344e-01	0.512
PKA-mediated phosphorylation of CREB	R-HSA-111931	2.189527e-01	0.660
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	3.433335e-01	0.464
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.986120e-01	0.399
Frs2-mediated activation	R-HSA-170968	2.711372e-01	0.567
Regulation of T cell activation by CD28 family	R-HSA-388841	3.845729e-01	0.415
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.754796e-01	0.323
DNA Replication Pre-Initiation	R-HSA-69002	1.888595e-01	0.724
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.437159e-01	0.613
Apoptosis induced DNA fragmentation	R-HSA-140342	3.269557e-01	0.486
Intraflagellar transport	R-HSA-5620924	2.557724e-01	0.592
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.942998e-01	0.531
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.062548e-01	0.514
Circadian clock	R-HSA-9909396	3.588342e-01	0.445
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.382378e-01	0.623
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.514503e-01	0.454
Regulation of CDH11 function	R-HSA-9762292	3.269557e-01	0.486
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.468749e-01	0.608
Deadenylation-dependent mRNA decay	R-HSA-429914	2.450908e-01	0.611
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.348786e-01	0.629
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.078344e-01	0.512
CRMPs in Sema3A signaling	R-HSA-399956	5.277393e-01	0.278
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.716984e-01	0.430
Apoptotic factor-mediated response	R-HSA-111471	2.862882e-01	0.543
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.614174e-01	0.583
Downregulation of ERBB2 signaling	R-HSA-8863795	3.258067e-01	0.487
Opioid Signalling	R-HSA-111885	5.138464e-01	0.289
GP1b-IX-V activation signalling	R-HSA-430116	2.850853e-01	0.545
TNF signaling	R-HSA-75893	5.312665e-01	0.275
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.902266e-01	0.409
Regulation of TNFR1 signaling	R-HSA-5357905	4.581282e-01	0.339
HIV Life Cycle	R-HSA-162587	3.825501e-01	0.417
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.382378e-01	0.623
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.951683e-01	0.530
Adrenoceptors	R-HSA-390696	2.437159e-01	0.613
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.437159e-01	0.613
NADPH regeneration	R-HSA-389542	4.060982e-01	0.391
PKA activation	R-HSA-163615	2.862882e-01	0.543
Budding and maturation of HIV virion	R-HSA-162588	2.196305e-01	0.658
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.986385e-01	0.702
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	3.746277e-01	0.426
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.491727e-01	0.457
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.123544e-01	0.673
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.506047e-01	0.346
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.506047e-01	0.346
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.506639e-01	0.455
RNA Polymerase I Transcription Termination	R-HSA-73863	4.035235e-01	0.394
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	5.079641e-01	0.294
PTEN Regulation	R-HSA-6807070	2.417466e-01	0.617
COPI-mediated anterograde transport	R-HSA-6807878	3.062548e-01	0.514
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	4.898877e-01	0.310
Synaptic adhesion-like molecules	R-HSA-8849932	4.768121e-01	0.322
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	4.916027e-01	0.308
Activation of HOX genes during differentiation	R-HSA-5619507	1.977997e-01	0.704
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.977997e-01	0.704
Late Phase of HIV Life Cycle	R-HSA-162599	2.836401e-01	0.547
trans-Golgi Network Vesicle Budding	R-HSA-199992	3.600792e-01	0.444
rRNA processing in the nucleus and cytosol	R-HSA-8868773	3.886233e-01	0.410
G-protein mediated events	R-HSA-112040	3.800892e-01	0.420
MAPK6/MAPK4 signaling	R-HSA-5687128	2.795469e-01	0.554
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.312747e-01	0.636
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.218709e-01	0.654
Signal attenuation	R-HSA-74749	3.269557e-01	0.486
Repression of WNT target genes	R-HSA-4641265	4.506047e-01	0.346
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.649006e-01	0.438
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.649006e-01	0.438
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.649006e-01	0.438
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.649006e-01	0.438
Cellular responses to mechanical stimuli	R-HSA-9855142	2.423147e-01	0.616
ER to Golgi Anterograde Transport	R-HSA-199977	4.913395e-01	0.309
Gene expression (Transcription)	R-HSA-74160	2.447399e-01	0.611
RNA Polymerase II Transcription	R-HSA-73857	2.007502e-01	0.697
Prolonged ERK activation events	R-HSA-169893	3.746277e-01	0.426
Platelet homeostasis	R-HSA-418346	3.734514e-01	0.428
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.932981e-01	0.533
HIV Infection	R-HSA-162906	2.402332e-01	0.619
Toll-like Receptor Cascades	R-HSA-168898	4.902446e-01	0.310
Sensory perception of sour taste	R-HSA-9729555	2.382378e-01	0.623
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.951683e-01	0.530
Transcription from mitochondrial promoters	R-HSA-75944	4.618343e-01	0.336
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.571032e-01	0.590
Abacavir transmembrane transport	R-HSA-2161517	4.060982e-01	0.391
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.775121e-01	0.557
Defective pyroptosis	R-HSA-9710421	2.706843e-01	0.568
p75NTR recruits signalling complexes	R-HSA-209543	4.506047e-01	0.346
Signaling by Hedgehog	R-HSA-5358351	5.280391e-01	0.277
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.870978e-01	0.542
PLC beta mediated events	R-HSA-112043	2.772462e-01	0.557
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.600792e-01	0.444
Transmission across Chemical Synapses	R-HSA-112315	5.256589e-01	0.279
G1 Phase	R-HSA-69236	4.149537e-01	0.382
Cyclin D associated events in G1	R-HSA-69231	4.149537e-01	0.382
Signaling by FGFR in disease	R-HSA-1226099	5.037656e-01	0.298
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	2.938134e-01	0.532
Cellular response to chemical stress	R-HSA-9711123	3.238460e-01	0.490
Regulated Necrosis	R-HSA-5218859	2.071788e-01	0.684
FGFR1 mutant receptor activation	R-HSA-1839124	2.614174e-01	0.583
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	4.091695e-01	0.388
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	3.763282e-01	0.424
Neuronal System	R-HSA-112316	3.673329e-01	0.435
DNA Replication	R-HSA-69306	3.370174e-01	0.472
rRNA modification in the nucleus and cytosol	R-HSA-6790901	3.106594e-01	0.508
Signaling by SCF-KIT	R-HSA-1433557	3.933037e-01	0.405
Signaling by NOTCH	R-HSA-157118	4.128248e-01	0.384
Formation of intermediate mesoderm	R-HSA-9761174	3.269557e-01	0.486
Regulation of TP53 Degradation	R-HSA-6804757	3.506639e-01	0.455
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.366799e-01	0.360
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.320411e-01	0.479
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	4.795302e-01	0.319
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.109231e-01	0.292
Interleukin-7 signaling	R-HSA-1266695	5.241033e-01	0.281
Metabolism of RNA	R-HSA-8953854	4.973811e-01	0.303
ERK/MAPK targets	R-HSA-198753	2.189527e-01	0.660
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.540805e-01	0.595
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.288939e-01	0.483
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.938041e-01	0.532
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.390569e-01	0.357
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.399368e-01	0.268
Signaling by PTK6	R-HSA-8848021	5.399368e-01	0.268
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	4.581282e-01	0.339
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	4.581282e-01	0.339
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.649006e-01	0.438
RUNX2 regulates bone development	R-HSA-8941326	2.275262e-01	0.643
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.160379e-01	0.500
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.258067e-01	0.487
Potassium Channels	R-HSA-1296071	4.907822e-01	0.309
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.575265e-01	0.340
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	4.795302e-01	0.319
Cell-cell junction organization	R-HSA-421270	2.854614e-01	0.544
Adherens junctions interactions	R-HSA-418990	3.229299e-01	0.491
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.492688e-01	0.603
Transcriptional regulation by RUNX3	R-HSA-8878159	5.060036e-01	0.296
Formation of editosomes by ADAR proteins	R-HSA-77042	2.663881e-01	0.574
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.716621e-01	0.430
Regulation of PTEN localization	R-HSA-8948747	2.034580e-01	0.692
Sodium/Calcium exchangers	R-HSA-425561	2.053153e-01	0.688
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.850853e-01	0.545
mRNA Editing: A to I Conversion	R-HSA-75064	4.618343e-01	0.336
Influenza Virus Induced Apoptosis	R-HSA-168277	4.618343e-01	0.336
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.618343e-01	0.336
C6 deamination of adenosine	R-HSA-75102	4.618343e-01	0.336
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.711372e-01	0.567
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.711372e-01	0.567
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	3.269557e-01	0.486
Regulation of KIT signaling	R-HSA-1433559	3.053238e-01	0.515
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	4.060982e-01	0.391
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	4.060982e-01	0.391
Ionotropic activity of kainate receptors	R-HSA-451306	3.687918e-01	0.433
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.986385e-01	0.702
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.667547e-01	0.574
Phase 3 - rapid repolarisation	R-HSA-5576890	4.584222e-01	0.339
MET activates STAT3	R-HSA-8875791	5.390705e-01	0.268
Activation of BMF and translocation to mitochondria	R-HSA-139910	5.390705e-01	0.268
Disorders of Developmental Biology	R-HSA-9675151	4.091695e-01	0.388
Signaling by LTK	R-HSA-9842663	4.506047e-01	0.346
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.736507e-01	0.428
Co-stimulation by ICOS	R-HSA-9927354	5.079641e-01	0.294
Membrane binding and targetting of GAG proteins	R-HSA-174490	4.898877e-01	0.310
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.768121e-01	0.322
Protein hydroxylation	R-HSA-9629569	5.412581e-01	0.267
Signaling by NOTCH1	R-HSA-1980143	4.280299e-01	0.369
Host Interactions of HIV factors	R-HSA-162909	1.828240e-01	0.738
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	2.793992e-01	0.554
Formation of the nephric duct	R-HSA-9830364	3.491727e-01	0.457
Gluconeogenesis	R-HSA-70263	5.007323e-01	0.300
Transcriptional regulation by RUNX2	R-HSA-8878166	3.262222e-01	0.486
Signaling by FGFR4 in disease	R-HSA-5655291	5.277393e-01	0.278
L1CAM interactions	R-HSA-373760	2.207741e-01	0.656
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.224896e-01	0.282
Interleukin-1 family signaling	R-HSA-446652	3.258618e-01	0.487
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.955414e-01	0.305
Signaling by NTRK2 (TRKB)	R-HSA-9006115	4.035235e-01	0.394
Platelet sensitization by LDL	R-HSA-432142	4.768121e-01	0.322
Interactions of Rev with host cellular proteins	R-HSA-177243	3.078344e-01	0.512
Downstream signal transduction	R-HSA-186763	3.504465e-01	0.455
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	2.506978e-01	0.601
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.998074e-01	0.699
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.071788e-01	0.684
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.940149e-01	0.404
Ion channel transport	R-HSA-983712	3.992946e-01	0.399
Gap junction trafficking and regulation	R-HSA-157858	3.899079e-01	0.409
Ion transport by P-type ATPases	R-HSA-936837	2.325046e-01	0.634
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	3.752688e-01	0.426
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.091346e-01	0.510
Stimuli-sensing channels	R-HSA-2672351	4.925752e-01	0.308
Uptake and function of diphtheria toxin	R-HSA-5336415	2.034580e-01	0.692
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.514503e-01	0.454
LGI-ADAM interactions	R-HSA-5682910	3.687918e-01	0.433
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.831498e-01	0.548
Transcriptional regulation by small RNAs	R-HSA-5578749	2.639865e-01	0.578
Pervasive developmental disorders	R-HSA-9005895	4.506047e-01	0.346
Disorders of Nervous System Development	R-HSA-9697154	4.506047e-01	0.346
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.506047e-01	0.346
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.581282e-01	0.339
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.277393e-01	0.278
Sensory processing of sound	R-HSA-9659379	1.998728e-01	0.699
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.096047e-01	0.388
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.332606e-01	0.363
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	4.584222e-01	0.339
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	2.831498e-01	0.548
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.399211e-01	0.469
Platelet degranulation	R-HSA-114608	5.281099e-01	0.277
MITF-M-regulated melanocyte development	R-HSA-9730414	2.258493e-01	0.646
Zygotic genome activation (ZGA)	R-HSA-9819196	3.764083e-01	0.424
Interleukin-6 signaling	R-HSA-1059683	4.898877e-01	0.310
Gap junction trafficking	R-HSA-190828	4.149537e-01	0.382
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.663591e-01	0.331
FLT3 Signaling	R-HSA-9607240	2.158418e-01	0.666
Kidney development	R-HSA-9830369	4.940118e-01	0.306
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	3.514503e-01	0.454
Tandem pore domain potassium channels	R-HSA-1296346	3.269557e-01	0.486
Signaling by PDGFR in disease	R-HSA-9671555	2.437627e-01	0.613
RHOBTB3 ATPase cycle	R-HSA-9706019	3.687918e-01	0.433
Intracellular oxygen transport	R-HSA-8981607	5.390705e-01	0.268
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.390705e-01	0.268
RAF-independent MAPK1/3 activation	R-HSA-112409	4.366799e-01	0.360
Regulation of gene expression in beta cells	R-HSA-210745	4.575265e-01	0.340
ISG15 antiviral mechanism	R-HSA-1169408	3.098404e-01	0.509
Base Excision Repair	R-HSA-73884	4.660764e-01	0.332
FLT3 signaling in disease	R-HSA-9682385	3.506639e-01	0.455
Uptake and actions of bacterial toxins	R-HSA-5339562	4.511652e-01	0.346
MITF-M-dependent gene expression	R-HSA-9856651	2.409769e-01	0.618
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	4.898877e-01	0.310
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.437627e-01	0.613
Nuclear import of Rev protein	R-HSA-180746	3.053267e-01	0.515
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.618343e-01	0.336
Trafficking of AMPA receptors	R-HSA-399719	2.196305e-01	0.658
Cation-coupled Chloride cotransporters	R-HSA-426117	4.584222e-01	0.339
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.657894e-01	0.332
Nephron development	R-HSA-9831926	2.862882e-01	0.543
Miscellaneous transport and binding events	R-HSA-5223345	4.250440e-01	0.372
Specification of primordial germ cells	R-HSA-9827857	4.433023e-01	0.353
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	2.951683e-01	0.530
Interleukin-1 processing	R-HSA-448706	2.850853e-01	0.545
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.514503e-01	0.454
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	5.079641e-01	0.294
MHC class II antigen presentation	R-HSA-2132295	3.000449e-01	0.523
Gap junction assembly	R-HSA-190861	4.498004e-01	0.347
Base-Excision Repair, AP Site Formation	R-HSA-73929	4.916027e-01	0.308
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.198398e-01	0.377
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.614174e-01	0.583
Cleavage of the damaged pyrimidine	R-HSA-110329	3.716984e-01	0.430
Depyrimidination	R-HSA-73928	3.716984e-01	0.430
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.906807e-01	0.720
Signaling by EGFR in Cancer	R-HSA-1643713	5.519376e-01	0.258
Myogenesis	R-HSA-525793	5.519376e-01	0.258
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.519376e-01	0.258
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	5.544449e-01	0.256
Gap junction degradation	R-HSA-190873	5.544449e-01	0.256
Inactivation of CDC42 and RAC1	R-HSA-428543	5.544449e-01	0.256
ALK mutants bind TKIs	R-HSA-9700645	5.544449e-01	0.256
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	5.544449e-01	0.256
MASTL Facilitates Mitotic Progression	R-HSA-2465910	5.544449e-01	0.256
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	5.544449e-01	0.256
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	5.544449e-01	0.256
mRNA Editing	R-HSA-75072	5.544449e-01	0.256
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	5.544449e-01	0.256
Regulation of NPAS4 gene transcription	R-HSA-9768777	5.544449e-01	0.256
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	5.544449e-01	0.256
ARMS-mediated activation	R-HSA-170984	5.544449e-01	0.256
Regulation of CDH11 gene transcription	R-HSA-9762293	5.544449e-01	0.256
Regulated proteolysis of p75NTR	R-HSA-193692	5.544449e-01	0.256
Respiratory syncytial virus genome replication	R-HSA-9834752	5.544449e-01	0.256
Butyrophilin (BTN) family interactions	R-HSA-8851680	5.544449e-01	0.256
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.547395e-01	0.256
Nuclear RNA decay	R-HSA-9930044	5.609634e-01	0.251
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.609634e-01	0.251
Activation of NF-kappaB in B cells	R-HSA-1169091	5.626303e-01	0.250
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.634268e-01	0.249
Erythropoietin activates RAS	R-HSA-9027284	5.639733e-01	0.249
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.639733e-01	0.249
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.639733e-01	0.249
Spry regulation of FGF signaling	R-HSA-1295596	5.639733e-01	0.249
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.639733e-01	0.249
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.639733e-01	0.249
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.639733e-01	0.249
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.639733e-01	0.249
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.688887e-01	0.245
Stabilization of p53	R-HSA-69541	5.688887e-01	0.245
Synthesis of DNA	R-HSA-69239	5.715856e-01	0.243
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	5.719144e-01	0.243
ESR-mediated signaling	R-HSA-8939211	5.727679e-01	0.242
Formation of a pool of free 40S subunits	R-HSA-72689	5.744831e-01	0.241
Fanconi Anemia Pathway	R-HSA-6783310	5.760195e-01	0.240
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	5.760195e-01	0.240
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.789536e-01	0.237
Interaction between L1 and Ankyrins	R-HSA-445095	5.789536e-01	0.237
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.789536e-01	0.237
Insulin processing	R-HSA-264876	5.789536e-01	0.237
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	5.825435e-01	0.235
Integration of energy metabolism	R-HSA-163685	5.850436e-01	0.233
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.853609e-01	0.233
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.856346e-01	0.232
Signaling by Nuclear Receptors	R-HSA-9006931	5.867254e-01	0.232
Signaling by VEGF	R-HSA-194138	5.877011e-01	0.231
Extension of Telomeres	R-HSA-180786	5.885857e-01	0.230
Diseases associated with the TLR signaling cascade	R-HSA-5602358	5.912846e-01	0.228
Diseases of Immune System	R-HSA-5260271	5.912846e-01	0.228
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	5.977227e-01	0.224
Josephin domain DUBs	R-HSA-5689877	5.977227e-01	0.224
PI3K/AKT activation	R-HSA-198203	5.977227e-01	0.224
EGFR Transactivation by Gastrin	R-HSA-2179392	5.977227e-01	0.224
Receptor Mediated Mitophagy	R-HSA-8934903	5.977227e-01	0.224
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.977227e-01	0.224
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	5.977227e-01	0.224
Signaling by Leptin	R-HSA-2586552	5.977227e-01	0.224
Defective GALNT12 causes CRCS1	R-HSA-5083636	5.984561e-01	0.223
Negative regulation of FLT3	R-HSA-9706369	5.984561e-01	0.223
Ca2+ pathway	R-HSA-4086398	5.995507e-01	0.222
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.013848e-01	0.221
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	6.013848e-01	0.221
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.013848e-01	0.221
Mitochondrial calcium ion transport	R-HSA-8949215	6.013848e-01	0.221
Assembly Of The HIV Virion	R-HSA-175474	6.013848e-01	0.221
Regulation of PTEN stability and activity	R-HSA-8948751	6.020322e-01	0.220
Signaling by FGFR2	R-HSA-5654738	6.045860e-01	0.219
Negative regulation of FGFR3 signaling	R-HSA-5654732	6.050757e-01	0.218
Pyroptosis	R-HSA-5620971	6.050757e-01	0.218
ATP sensitive Potassium channels	R-HSA-1296025	6.052257e-01	0.218
AKT-mediated inactivation of FOXO1A	R-HSA-211163	6.052257e-01	0.218
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	6.052257e-01	0.218
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	6.052257e-01	0.218
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	R-HSA-2978092	6.052257e-01	0.218
Defective LFNG causes SCDO3	R-HSA-5083630	6.052257e-01	0.218
Regulation of gap junction activity	R-HSA-191650	6.052257e-01	0.218
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	6.052257e-01	0.218
Inhibition of TSC complex formation by PKB	R-HSA-165181	6.052257e-01	0.218
MDK and PTN in ALK signaling	R-HSA-9851151	6.052257e-01	0.218
Dopamine receptors	R-HSA-390651	6.052257e-01	0.218
Regulation of HMOX1 expression and activity	R-HSA-9707587	6.052257e-01	0.218
Interleukin-38 signaling	R-HSA-9007892	6.052257e-01	0.218
Signaling by ERBB2	R-HSA-1227986	6.069708e-01	0.217
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	6.086537e-01	0.216
Dual Incision in GG-NER	R-HSA-5696400	6.090404e-01	0.215
Mitophagy	R-HSA-5205647	6.090404e-01	0.215
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	6.090404e-01	0.215
Platelet activation, signaling and aggregation	R-HSA-76002	6.111155e-01	0.214
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.130791e-01	0.212
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.130791e-01	0.212
TCR signaling	R-HSA-202403	6.131643e-01	0.212
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.174495e-01	0.209
RNA Polymerase II Transcription Termination	R-HSA-73856	6.249459e-01	0.204
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.249459e-01	0.204
Transcription of the HIV genome	R-HSA-167172	6.287397e-01	0.202
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.295940e-01	0.201
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.295940e-01	0.201
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.295940e-01	0.201
Signaling by KIT in disease	R-HSA-9669938	6.295940e-01	0.201
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	6.295940e-01	0.201
mRNA Capping	R-HSA-72086	6.302434e-01	0.200
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	6.302434e-01	0.200
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.302434e-01	0.200
Eukaryotic Translation Initiation	R-HSA-72613	6.305418e-01	0.200
Cap-dependent Translation Initiation	R-HSA-72737	6.305418e-01	0.200
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.310994e-01	0.200
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.310994e-01	0.200
Signalling to ERKs	R-HSA-187687	6.319530e-01	0.199
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	6.324421e-01	0.199
HCMV Infection	R-HSA-9609646	6.327957e-01	0.199
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.342318e-01	0.198
Degradation of GLI2 by the proteasome	R-HSA-5610783	6.342318e-01	0.198
Co-stimulation by CD28	R-HSA-389356	6.368299e-01	0.196
PECAM1 interactions	R-HSA-210990	6.377595e-01	0.195
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	6.377595e-01	0.195
Bicarbonate transporters	R-HSA-425381	6.377595e-01	0.195
Transport of RCbl within the body	R-HSA-9758890	6.377595e-01	0.195
CD163 mediating an anti-inflammatory response	R-HSA-9662834	6.377595e-01	0.195
Synthesis of PI	R-HSA-1483226	6.377595e-01	0.195
Nonsense-Mediated Decay (NMD)	R-HSA-927802	6.398495e-01	0.194
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	6.398495e-01	0.194
Mitochondrial protein import	R-HSA-1268020	6.424864e-01	0.192
Mitochondrial protein degradation	R-HSA-9837999	6.430133e-01	0.192
Developmental Biology	R-HSA-1266738	6.474938e-01	0.189
Triglyceride catabolism	R-HSA-163560	6.540588e-01	0.184
DAP12 signaling	R-HSA-2424491	6.544100e-01	0.184
Interleukin receptor SHC signaling	R-HSA-912526	6.564888e-01	0.183
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.564888e-01	0.183
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.564888e-01	0.183
Carnitine shuttle	R-HSA-200425	6.564888e-01	0.183
Syndecan interactions	R-HSA-3000170	6.564888e-01	0.183
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.576430e-01	0.182
Interleukin-1 signaling	R-HSA-9020702	6.599800e-01	0.180
PI3K events in ERBB2 signaling	R-HSA-1963642	6.618541e-01	0.179
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.618541e-01	0.179
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.618541e-01	0.179
Regulation of NPAS4 gene expression	R-HSA-9768759	6.618541e-01	0.179
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.618541e-01	0.179
Uptake and function of anthrax toxins	R-HSA-5210891	6.618541e-01	0.179
Defective F9 activation	R-HSA-9673221	6.618892e-01	0.179
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	6.618892e-01	0.179
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	6.618892e-01	0.179
FLT3 signaling by CBL mutants	R-HSA-9706377	6.618892e-01	0.179
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	6.618892e-01	0.179
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.618892e-01	0.179
Activation of C3 and C5	R-HSA-174577	6.618892e-01	0.179
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.618892e-01	0.179
PTK6 Activates STAT3	R-HSA-8849474	6.618892e-01	0.179
Muscarinic acetylcholine receptors	R-HSA-390648	6.618892e-01	0.179
Inositol transporters	R-HSA-429593	6.618892e-01	0.179
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.618892e-01	0.179
NrCAM interactions	R-HSA-447038	6.618892e-01	0.179
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	6.678492e-01	0.175
Adipogenesis	R-HSA-9843745	6.737318e-01	0.172
Signaling by FGFR4	R-HSA-5654743	6.744839e-01	0.171
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	6.745940e-01	0.171
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	6.745940e-01	0.171
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	6.745940e-01	0.171
Synthesis of diphthamide-EEF2	R-HSA-5358493	6.745940e-01	0.171
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	6.745940e-01	0.171
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	6.745940e-01	0.171
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	6.745940e-01	0.171
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	6.745940e-01	0.171
NF-kB is activated and signals survival	R-HSA-209560	6.745940e-01	0.171
Integration of provirus	R-HSA-162592	6.745940e-01	0.171
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.745940e-01	0.171
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	6.753272e-01	0.170
Ovarian tumor domain proteases	R-HSA-5689896	6.753272e-01	0.170
EGFR downregulation	R-HSA-182971	6.775414e-01	0.169
Complex III assembly	R-HSA-9865881	6.820355e-01	0.166
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	6.820355e-01	0.166
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.907039e-01	0.161
Mismatch Repair	R-HSA-5358508	6.907039e-01	0.161
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.907039e-01	0.161
Interferon Signaling	R-HSA-913531	6.936799e-01	0.159
MET promotes cell motility	R-HSA-8875878	6.957356e-01	0.158
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.957356e-01	0.158
Inwardly rectifying K+ channels	R-HSA-1296065	6.996155e-01	0.155
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.062178e-01	0.151
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.083206e-01	0.150
GRB2 events in EGFR signaling	R-HSA-179812	7.083206e-01	0.150
Scavenging by Class F Receptors	R-HSA-3000484	7.083206e-01	0.150
Interleukin-15 signaling	R-HSA-8983432	7.083206e-01	0.150
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	7.083206e-01	0.150
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	7.083206e-01	0.150
Regulation of IFNG signaling	R-HSA-877312	7.083206e-01	0.150
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.083206e-01	0.150
Estrogen biosynthesis	R-HSA-193144	7.083206e-01	0.150
Polymerase switching	R-HSA-69091	7.083206e-01	0.150
Leading Strand Synthesis	R-HSA-69109	7.083206e-01	0.150
OAS antiviral response	R-HSA-8983711	7.083206e-01	0.150
Plus-strand DNA synthesis	R-HSA-164525	7.104223e-01	0.148
PDE3B signalling	R-HSA-165160	7.104223e-01	0.148
Noncanonical activation of NOTCH3	R-HSA-9017802	7.104223e-01	0.148
PKB-mediated events	R-HSA-109703	7.104223e-01	0.148
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	7.104223e-01	0.148
PTK6 Regulates Cell Cycle	R-HSA-8849470	7.104223e-01	0.148
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	7.104223e-01	0.148
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	7.104223e-01	0.148
Signaling by RNF43 mutants	R-HSA-5340588	7.104223e-01	0.148
Defective CSF2RA causes SMDP4	R-HSA-5688890	7.104223e-01	0.148
Defective CSF2RB causes SMDP5	R-HSA-5688849	7.104223e-01	0.148
Signaling by MST1	R-HSA-8852405	7.104223e-01	0.148
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	7.104223e-01	0.148
Pentose phosphate pathway disease	R-HSA-6791465	7.104223e-01	0.148
Cam-PDE 1 activation	R-HSA-111957	7.104223e-01	0.148
Formation of the Editosome	R-HSA-75094	7.104223e-01	0.148
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	7.104223e-01	0.148
Signalling to p38 via RIT and RIN	R-HSA-187706	7.104223e-01	0.148
Negative feedback regulation of MAPK pathway	R-HSA-5674499	7.104223e-01	0.148
Release of apoptotic factors from the mitochondria	R-HSA-111457	7.104223e-01	0.148
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	7.104223e-01	0.148
Sodium-coupled phosphate cotransporters	R-HSA-427652	7.104223e-01	0.148
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	7.104223e-01	0.148
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	7.104223e-01	0.148
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	7.104223e-01	0.148
Asymmetric localization of PCP proteins	R-HSA-4608870	7.118478e-01	0.148
Signaling by FGFR3	R-HSA-5654741	7.118478e-01	0.148
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.118478e-01	0.148
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	7.152692e-01	0.146
PI-3K cascade:FGFR3	R-HSA-5654710	7.176596e-01	0.144
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.176596e-01	0.144
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.176596e-01	0.144
STING mediated induction of host immune responses	R-HSA-1834941	7.176596e-01	0.144
G-protein beta:gamma signalling	R-HSA-397795	7.206204e-01	0.142
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.206204e-01	0.142
Cardiogenesis	R-HSA-9733709	7.206204e-01	0.142
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.206204e-01	0.142
Signaling by ERBB4	R-HSA-1236394	7.223007e-01	0.141
Inositol phosphate metabolism	R-HSA-1483249	7.244581e-01	0.140
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.290347e-01	0.137
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.290347e-01	0.137
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.294120e-01	0.137
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.326758e-01	0.135
Generation of second messenger molecules	R-HSA-202433	7.339203e-01	0.134
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.339203e-01	0.134
Glycogen metabolism	R-HSA-8982491	7.339203e-01	0.134
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.363021e-01	0.133
Acetylcholine binding and downstream events	R-HSA-181431	7.390724e-01	0.131
CD28 dependent Vav1 pathway	R-HSA-389359	7.390724e-01	0.131
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	7.390724e-01	0.131
PI5P Regulates TP53 Acetylation	R-HSA-6811555	7.390724e-01	0.131
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	7.390724e-01	0.131
Replication of the SARS-CoV-1 genome	R-HSA-9682706	7.390724e-01	0.131
Beta-catenin independent WNT signaling	R-HSA-3858494	7.390984e-01	0.131
Viral Messenger RNA Synthesis	R-HSA-168325	7.395498e-01	0.131
Glucagon signaling in metabolic regulation	R-HSA-163359	7.405539e-01	0.130
Gastrulation	R-HSA-9758941	7.411672e-01	0.130
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.427541e-01	0.129
Negative regulation of MET activity	R-HSA-6807004	7.427541e-01	0.129
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.427541e-01	0.129
PI-3K cascade:FGFR4	R-HSA-5654720	7.427541e-01	0.129
VxPx cargo-targeting to cilium	R-HSA-5620916	7.427541e-01	0.129
Formation of definitive endoderm	R-HSA-9823730	7.427541e-01	0.129
Signal transduction by L1	R-HSA-445144	7.427541e-01	0.129
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.427541e-01	0.129
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.462228e-01	0.127
Gene Silencing by RNA	R-HSA-211000	7.468689e-01	0.127
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.471260e-01	0.127
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.471260e-01	0.127
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.504980e-01	0.125
Signaling by FGFR3 in disease	R-HSA-5655332	7.504980e-01	0.125
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.504980e-01	0.125
Potential therapeutics for SARS	R-HSA-9679191	7.507629e-01	0.124
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	7.516874e-01	0.124
Signaling by LTK in cancer	R-HSA-9842640	7.519913e-01	0.124
Erythropoietin activates STAT5	R-HSA-9027283	7.519913e-01	0.124
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.519913e-01	0.124
Uncoating of the HIV Virion	R-HSA-162585	7.519913e-01	0.124
Hydrolysis of LPE	R-HSA-1483152	7.519913e-01	0.124
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	7.519913e-01	0.124
MET Receptor Activation	R-HSA-6806942	7.519913e-01	0.124
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	7.519913e-01	0.124
CREB3 factors activate genes	R-HSA-8874211	7.519913e-01	0.124
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.519913e-01	0.124
Signaling by NOTCH3	R-HSA-9012852	7.576413e-01	0.121
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	7.594219e-01	0.120
NOD1/2 Signaling Pathway	R-HSA-168638	7.594219e-01	0.120
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.594219e-01	0.120
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.594219e-01	0.120
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.608335e-01	0.119
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	7.622799e-01	0.118
Metal ion SLC transporters	R-HSA-425410	7.622799e-01	0.118
rRNA processing	R-HSA-72312	7.638278e-01	0.117
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.660380e-01	0.116
Basigin interactions	R-HSA-210991	7.660380e-01	0.116
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.660380e-01	0.116
NRIF signals cell death from the nucleus	R-HSA-205043	7.670085e-01	0.115
Removal of the Flap Intermediate	R-HSA-69166	7.670085e-01	0.115
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.670085e-01	0.115
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.670085e-01	0.115
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	7.670085e-01	0.115
Physiological factors	R-HSA-5578768	7.670085e-01	0.115
HDL assembly	R-HSA-8963896	7.670085e-01	0.115
Zinc transporters	R-HSA-435354	7.670085e-01	0.115
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	7.670085e-01	0.115
Intra-Golgi traffic	R-HSA-6811438	7.685747e-01	0.114
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	7.692666e-01	0.114
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.706304e-01	0.113
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.706304e-01	0.113
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	7.716318e-01	0.113
Signaling by EGFR	R-HSA-177929	7.723012e-01	0.112
Signaling by FGFR1	R-HSA-5654736	7.723012e-01	0.112
Downstream signaling of activated FGFR1	R-HSA-5654687	7.772378e-01	0.109
Degradation of CDH1	R-HSA-9766229	7.775872e-01	0.109
Hedgehog 'on' state	R-HSA-5632684	7.782196e-01	0.109
Signaling by TGFB family members	R-HSA-9006936	7.785041e-01	0.109
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.845915e-01	0.105
IRS-mediated signalling	R-HSA-112399	7.863075e-01	0.104
Regulation of CDH1 Function	R-HSA-9764561	7.863075e-01	0.104
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.868329e-01	0.104
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.875751e-01	0.104
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.875751e-01	0.104
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.875751e-01	0.104
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	7.875786e-01	0.104
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.875951e-01	0.104
Netrin mediated repulsion signals	R-HSA-418886	7.875951e-01	0.104
DAG1 core M1 glycosylations	R-HSA-8932506	7.875951e-01	0.104
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	7.875951e-01	0.104
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.875951e-01	0.104
mRNA Editing: C to U Conversion	R-HSA-72200	7.875951e-01	0.104
PTK6 Expression	R-HSA-8849473	7.875951e-01	0.104
Activated NTRK3 signals through PI3K	R-HSA-9603381	7.875951e-01	0.104
Ca2+ activated K+ channels	R-HSA-1296052	7.875951e-01	0.104
Synthesis of PIPs in the nucleus	R-HSA-8847453	7.875951e-01	0.104
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.875951e-01	0.104
Glycoprotein hormones	R-HSA-209822	7.875951e-01	0.104
CHL1 interactions	R-HSA-447041	7.875951e-01	0.104
Nef Mediated CD4 Down-regulation	R-HSA-167590	7.875951e-01	0.104
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.875951e-01	0.104
Maturation of replicase proteins	R-HSA-9694301	7.875951e-01	0.104
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.878320e-01	0.104
Downstream signaling of activated FGFR3	R-HSA-5654708	7.894640e-01	0.103
Signaling by CSF3 (G-CSF)	R-HSA-9674555	7.894640e-01	0.103
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	7.894640e-01	0.103
Termination of translesion DNA synthesis	R-HSA-5656169	7.894640e-01	0.103
Signaling by FGFR	R-HSA-190236	7.921202e-01	0.101
Regulation of RAS by GAPs	R-HSA-5658442	7.921520e-01	0.101
PI3K Cascade	R-HSA-109704	7.921520e-01	0.101
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	7.923033e-01	0.101
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	7.923033e-01	0.101
SHC1 events in EGFR signaling	R-HSA-180336	7.923033e-01	0.101
G beta:gamma signalling through BTK	R-HSA-8964315	7.923033e-01	0.101
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	7.923033e-01	0.101
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.923033e-01	0.101
Processive synthesis on the lagging strand	R-HSA-69183	7.923033e-01	0.101
Telomere C-strand synthesis initiation	R-HSA-174430	7.923033e-01	0.101
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	7.923033e-01	0.101
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	7.923033e-01	0.101
Biotin transport and metabolism	R-HSA-196780	7.923033e-01	0.101
Other semaphorin interactions	R-HSA-416700	7.923033e-01	0.101
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	7.923033e-01	0.101
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.940210e-01	0.100
RNA Polymerase III Transcription	R-HSA-74158	7.940210e-01	0.100
GPVI-mediated activation cascade	R-HSA-114604	7.940210e-01	0.100
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.963038e-01	0.099
XBP1(S) activates chaperone genes	R-HSA-381038	7.963038e-01	0.099
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.965056e-01	0.099
Signaling by MET	R-HSA-6806834	7.991583e-01	0.097
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	7.996667e-01	0.097
Downstream signaling of activated FGFR4	R-HSA-5654716	8.070379e-01	0.093
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.070379e-01	0.093
SHC1 events in ERBB2 signaling	R-HSA-1250196	8.070379e-01	0.093
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.070379e-01	0.093
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.074397e-01	0.093
PI-3K cascade:FGFR1	R-HSA-5654689	8.074397e-01	0.093
Regulation of IFNA/IFNB signaling	R-HSA-912694	8.074397e-01	0.093
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.074397e-01	0.093
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	8.074397e-01	0.093
Neurotoxicity of clostridium toxins	R-HSA-168799	8.074397e-01	0.093
Degradation of AXIN	R-HSA-4641257	8.097962e-01	0.092
Degradation of DVL	R-HSA-4641258	8.097962e-01	0.092
HCMV Late Events	R-HSA-9610379	8.114674e-01	0.091
Regulation of beta-cell development	R-HSA-186712	8.123878e-01	0.090
Proteasome assembly	R-HSA-9907900	8.140728e-01	0.089
Amine ligand-binding receptors	R-HSA-375280	8.140728e-01	0.089
Signaling by NOTCH4	R-HSA-9013694	8.141275e-01	0.089
Defective GALNT3 causes HFTC	R-HSA-5083625	8.151394e-01	0.089
Induction of Cell-Cell Fusion	R-HSA-9733458	8.151394e-01	0.089
Activation of SMO	R-HSA-5635838	8.151394e-01	0.089
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.151394e-01	0.089
Regulation of BACH1 activity	R-HSA-9708530	8.151394e-01	0.089
Regulation of NF-kappa B signaling	R-HSA-9758274	8.151394e-01	0.089
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.151394e-01	0.089
Differentiation of T cells	R-HSA-9945266	8.151394e-01	0.089
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.151394e-01	0.089
Serotonin and melatonin biosynthesis	R-HSA-209931	8.151394e-01	0.089
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	8.151394e-01	0.089
Atorvastatin ADME	R-HSA-9754706	8.151394e-01	0.089
Reverse Transcription of HIV RNA	R-HSA-162589	8.180894e-01	0.087
Minus-strand DNA synthesis	R-HSA-164516	8.180894e-01	0.087
RSK activation	R-HSA-444257	8.180894e-01	0.087
EGFR interacts with phospholipase C-gamma	R-HSA-212718	8.180894e-01	0.087
DAG1 core M2 glycosylations	R-HSA-8932504	8.180894e-01	0.087
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	8.180894e-01	0.087
FGFR1b ligand binding and activation	R-HSA-190370	8.180894e-01	0.087
Regulation of NPAS4 mRNA translation	R-HSA-9768778	8.180894e-01	0.087
Formation of annular gap junctions	R-HSA-196025	8.180894e-01	0.087
Activated NTRK2 signals through PI3K	R-HSA-9028335	8.180894e-01	0.087
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	8.180894e-01	0.087
Fructose biosynthesis	R-HSA-5652227	8.180894e-01	0.087
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	8.180894e-01	0.087
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	8.180894e-01	0.087
Downregulation of ERBB4 signaling	R-HSA-1253288	8.180894e-01	0.087
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	8.180894e-01	0.087
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	8.180894e-01	0.087
Activated NTRK2 signals through FYN	R-HSA-9032500	8.180894e-01	0.087
Sodium/Proton exchangers	R-HSA-425986	8.180894e-01	0.087
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.191004e-01	0.087
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	8.191004e-01	0.087
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	8.197428e-01	0.086
Selenocysteine synthesis	R-HSA-2408557	8.219266e-01	0.085
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.220410e-01	0.085
Evasion by RSV of host interferon responses	R-HSA-9833109	8.233972e-01	0.084
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.233972e-01	0.084
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.244819e-01	0.084
Influenza Infection	R-HSA-168255	8.253859e-01	0.083
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.257129e-01	0.083
Interleukin-20 family signaling	R-HSA-8854691	8.257129e-01	0.083
Growth hormone receptor signaling	R-HSA-982772	8.257129e-01	0.083
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.275755e-01	0.082
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.275755e-01	0.082
Cytoprotection by HMOX1	R-HSA-9707564	8.312071e-01	0.080
Eukaryotic Translation Termination	R-HSA-72764	8.339002e-01	0.079
G beta:gamma signalling through CDC42	R-HSA-8964616	8.357013e-01	0.078
Phase 2 - plateau phase	R-HSA-5576893	8.357013e-01	0.078
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.357013e-01	0.078
TRAF3-dependent IRF activation pathway	R-HSA-918233	8.357013e-01	0.078
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.357013e-01	0.078
Galactose catabolism	R-HSA-70370	8.357013e-01	0.078
Synthesis of PG	R-HSA-1483148	8.357013e-01	0.078
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.357013e-01	0.078
IRS-related events triggered by IGF1R	R-HSA-2428928	8.359623e-01	0.078
Downstream TCR signaling	R-HSA-202424	8.371546e-01	0.077
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.384424e-01	0.077
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.385914e-01	0.076
Signaling by TGFBR3	R-HSA-9839373	8.402835e-01	0.076
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.424808e-01	0.074
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.424808e-01	0.074
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.424808e-01	0.074
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.424808e-01	0.074
Interleukin-6 family signaling	R-HSA-6783589	8.424808e-01	0.074
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.424808e-01	0.074
Plasma lipoprotein assembly	R-HSA-8963898	8.424808e-01	0.074
Translation initiation complex formation	R-HSA-72649	8.432430e-01	0.074
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.442072e-01	0.074
Unwinding of DNA	R-HSA-176974	8.442072e-01	0.074
Enzymatic degradation of Dopamine by monoamine oxidase	R-HSA-379398	8.442072e-01	0.074
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	8.442072e-01	0.074
Regulation of signaling by NODAL	R-HSA-1433617	8.442072e-01	0.074
Defects in biotin (Btn) metabolism	R-HSA-3323169	8.442072e-01	0.074
Translation of Structural Proteins	R-HSA-9694635	8.454801e-01	0.073
SARS-CoV-1 Infection	R-HSA-9678108	8.462668e-01	0.072
Signaling by PDGF	R-HSA-186797	8.468436e-01	0.072
tRNA processing in the nucleus	R-HSA-6784531	8.468436e-01	0.072
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.541712e-01	0.068
Regulation of FZD by ubiquitination	R-HSA-4641263	8.541712e-01	0.068
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.541712e-01	0.068
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.541712e-01	0.068
Leishmania infection	R-HSA-9658195	8.545323e-01	0.068
Parasitic Infection Pathways	R-HSA-9824443	8.545323e-01	0.068
IRE1alpha activates chaperones	R-HSA-381070	8.550827e-01	0.068
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.578317e-01	0.067
PI-3K cascade:FGFR2	R-HSA-5654695	8.578317e-01	0.067
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.578317e-01	0.067
Activation of G protein gated Potassium channels	R-HSA-1296041	8.578317e-01	0.067
G protein gated Potassium channels	R-HSA-1296059	8.578317e-01	0.067
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.578317e-01	0.067
VEGFR2 mediated cell proliferation	R-HSA-5218921	8.578317e-01	0.067
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.591986e-01	0.066
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.634469e-01	0.064
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.634491e-01	0.064
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.656977e-01	0.063
Vpu mediated degradation of CD4	R-HSA-180534	8.656977e-01	0.063
C-type lectin receptors (CLRs)	R-HSA-5621481	8.659627e-01	0.063
Binding and entry of HIV virion	R-HSA-173107	8.665765e-01	0.062
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	8.665765e-01	0.062
2-LTR circle formation	R-HSA-164843	8.665765e-01	0.062
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.665765e-01	0.062
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	8.665765e-01	0.062
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.665765e-01	0.062
Pexophagy	R-HSA-9664873	8.665765e-01	0.062
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.665765e-01	0.062
Enzymatic degradation of dopamine by COMT	R-HSA-379397	8.665765e-01	0.062
Metabolism of serotonin	R-HSA-380612	8.665765e-01	0.062
Arachidonate production from DAG	R-HSA-426048	8.665765e-01	0.062
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.665765e-01	0.062
CASP4 inflammasome assembly	R-HSA-9948001	8.665765e-01	0.062
Interleukin-27 signaling	R-HSA-9020956	8.665765e-01	0.062
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.665765e-01	0.062
Sperm Motility And Taxes	R-HSA-1300642	8.665765e-01	0.062
MAPK3 (ERK1) activation	R-HSA-110056	8.665765e-01	0.062
Defective factor IX causes hemophilia B	R-HSA-9668250	8.665765e-01	0.062
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.665765e-01	0.062
Peptide hormone biosynthesis	R-HSA-209952	8.665765e-01	0.062
Serotonin receptors	R-HSA-390666	8.665765e-01	0.062
Insulin receptor signalling cascade	R-HSA-74751	8.668754e-01	0.062
IGF1R signaling cascade	R-HSA-2428924	8.668754e-01	0.062
Cellular response to starvation	R-HSA-9711097	8.683645e-01	0.061
GAB1 signalosome	R-HSA-180292	8.707259e-01	0.060
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.707259e-01	0.060
Tie2 Signaling	R-HSA-210993	8.707259e-01	0.060
Vitamin D (calciferol) metabolism	R-HSA-196791	8.707259e-01	0.060
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.707259e-01	0.060
SARS-CoV-1-host interactions	R-HSA-9692914	8.718204e-01	0.060
Abacavir ADME	R-HSA-2161522	8.718552e-01	0.060
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.718552e-01	0.060
Ribosome-associated quality control	R-HSA-9948299	8.731631e-01	0.059
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.746778e-01	0.058
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.746778e-01	0.058
Translation of Structural Proteins	R-HSA-9683701	8.746778e-01	0.058
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.760616e-01	0.057
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.777209e-01	0.057
NPAS4 regulates expression of target genes	R-HSA-9768919	8.777209e-01	0.057
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.777209e-01	0.057
Amyloid fiber formation	R-HSA-977225	8.806570e-01	0.055
Signaling by FGFR2 in disease	R-HSA-5655253	8.837078e-01	0.054
Dual incision in TC-NER	R-HSA-6782135	8.837429e-01	0.054
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.837429e-01	0.054
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.837429e-01	0.054
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	8.846400e-01	0.053
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.855343e-01	0.053
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.855343e-01	0.053
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	8.855343e-01	0.053
Crosslinking of collagen fibrils	R-HSA-2243919	8.855343e-01	0.053
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	8.855343e-01	0.053
Other interleukin signaling	R-HSA-449836	8.855343e-01	0.053
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.855343e-01	0.053
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.857350e-01	0.053
DAG1 core M3 glycosylations	R-HSA-8932505	8.857350e-01	0.053
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.857350e-01	0.053
FGFR2b ligand binding and activation	R-HSA-190377	8.857350e-01	0.053
Activated NTRK3 signals through RAS	R-HSA-9034864	8.857350e-01	0.053
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.857350e-01	0.053
vRNA Synthesis	R-HSA-192814	8.857350e-01	0.053
vRNP Assembly	R-HSA-192905	8.857350e-01	0.053
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.857350e-01	0.053
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.857350e-01	0.053
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.857350e-01	0.053
Chylomicron assembly	R-HSA-8963888	8.857350e-01	0.053
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.857350e-01	0.053
Suppression of apoptosis	R-HSA-9635465	8.857350e-01	0.053
Dissolution of Fibrin Clot	R-HSA-75205	8.857350e-01	0.053
Downstream signaling of activated FGFR2	R-HSA-5654696	8.887993e-01	0.051
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.887993e-01	0.051
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.887993e-01	0.051
Regulation of Apoptosis	R-HSA-169911	8.887993e-01	0.051
Triglyceride metabolism	R-HSA-8979227	8.923780e-01	0.049
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.947958e-01	0.048
Viral mRNA Translation	R-HSA-192823	8.957632e-01	0.048
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.962733e-01	0.048
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.987567e-01	0.046
Creatine metabolism	R-HSA-71288	8.987567e-01	0.046
Signaling by NODAL	R-HSA-1181150	8.987567e-01	0.046
Pregnenolone biosynthesis	R-HSA-196108	8.987567e-01	0.046
Immune System	R-HSA-168256	8.991814e-01	0.046
GABA receptor activation	R-HSA-977443	9.004655e-01	0.046
Developmental Cell Lineages	R-HSA-9734767	9.009588e-01	0.045
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	9.021434e-01	0.045
Activated NTRK2 signals through RAS	R-HSA-9026519	9.021434e-01	0.045
Plasmalogen biosynthesis	R-HSA-75896	9.021434e-01	0.045
Signaling by activated point mutants of FGFR1	R-HSA-1839122	9.021434e-01	0.045
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	9.021434e-01	0.045
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	9.021434e-01	0.045
FMO oxidises nucleophiles	R-HSA-217271	9.021434e-01	0.045
DAP12 interactions	R-HSA-2172127	9.037635e-01	0.044
Aquaporin-mediated transport	R-HSA-445717	9.080299e-01	0.042
Formation of paraxial mesoderm	R-HSA-9793380	9.080299e-01	0.042
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.105431e-01	0.041
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.105431e-01	0.041
G-protein activation	R-HSA-202040	9.105431e-01	0.041
Early Phase of HIV Life Cycle	R-HSA-162594	9.105431e-01	0.041
Lagging Strand Synthesis	R-HSA-69186	9.105431e-01	0.041
Signalling to RAS	R-HSA-167044	9.105431e-01	0.041
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.120572e-01	0.040
Somitogenesis	R-HSA-9824272	9.120572e-01	0.040
COPII-mediated vesicle transport	R-HSA-204005	9.144727e-01	0.039
PCP/CE pathway	R-HSA-4086400	9.145539e-01	0.039
IRAK1 recruits IKK complex	R-HSA-937039	9.161964e-01	0.038
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	9.161964e-01	0.038
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	9.161964e-01	0.038
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	9.161964e-01	0.038
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	9.161964e-01	0.038
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	9.161964e-01	0.038
Interleukin-35 Signalling	R-HSA-8984722	9.161964e-01	0.038
Proline catabolism	R-HSA-70688	9.161964e-01	0.038
SHC-related events triggered by IGF1R	R-HSA-2428933	9.161964e-01	0.038
Trafficking and processing of endosomal TLR	R-HSA-1679131	9.161964e-01	0.038
Diseases associated with surfactant metabolism	R-HSA-5687613	9.161964e-01	0.038
RUNX3 regulates p14-ARF	R-HSA-8951936	9.161964e-01	0.038
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.161964e-01	0.038
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.164216e-01	0.038
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.164216e-01	0.038
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.169255e-01	0.038
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.197165e-01	0.036
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.210331e-01	0.036
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.210331e-01	0.036
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.210331e-01	0.036
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.247787e-01	0.034
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.250960e-01	0.034
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.250960e-01	0.034
Cargo concentration in the ER	R-HSA-5694530	9.250960e-01	0.034
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.268364e-01	0.033
Adenylate cyclase activating pathway	R-HSA-170660	9.282320e-01	0.032
FGFR2c ligand binding and activation	R-HSA-190375	9.282320e-01	0.032
Microbial factors inhibit CASP4 activity	R-HSA-9956593	9.282320e-01	0.032
Chylomicron remodeling	R-HSA-8963901	9.282320e-01	0.032
FGFR1c ligand binding and activation	R-HSA-190373	9.282320e-01	0.032
FGFR4 ligand binding and activation	R-HSA-190322	9.282320e-01	0.032
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.282320e-01	0.032
Mtb iron assimilation by chelation	R-HSA-1222449	9.282320e-01	0.032
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.282320e-01	0.032
Reversible hydration of carbon dioxide	R-HSA-1475029	9.282320e-01	0.032
FGFR3 mutant receptor activation	R-HSA-2033514	9.282320e-01	0.032
Processing of SMDT1	R-HSA-8949664	9.282320e-01	0.032
rRNA modification in the mitochondrion	R-HSA-6793080	9.282320e-01	0.032
Platelet Adhesion to exposed collagen	R-HSA-75892	9.282320e-01	0.032
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.297442e-01	0.032
Ribosomal scanning and start codon recognition	R-HSA-72702	9.299041e-01	0.032
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.299041e-01	0.032
Fructose metabolism	R-HSA-5652084	9.303559e-01	0.031
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.303559e-01	0.031
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.303559e-01	0.031
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.303559e-01	0.031
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.319571e-01	0.031
Nuclear signaling by ERBB4	R-HSA-1251985	9.319571e-01	0.031
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.319571e-01	0.031
DNA strand elongation	R-HSA-69190	9.329372e-01	0.030
GPER1 signaling	R-HSA-9634597	9.332846e-01	0.030
Adaptive Immune System	R-HSA-1280218	9.364692e-01	0.029
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.385096e-01	0.028
Hh mutants are degraded by ERAD	R-HSA-5362768	9.385096e-01	0.028
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.385396e-01	0.028
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	9.385396e-01	0.028
FGFR3c ligand binding and activation	R-HSA-190372	9.385396e-01	0.028
Transport of fatty acids	R-HSA-804914	9.385396e-01	0.028
Hydrolysis of LPC	R-HSA-1483115	9.385396e-01	0.028
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	9.385396e-01	0.028
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	9.385396e-01	0.028
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	9.385396e-01	0.028
Malate-aspartate shuttle	R-HSA-9856872	9.385396e-01	0.028
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.385396e-01	0.028
Non-canonical inflammasome activation	R-HSA-9686114	9.385396e-01	0.028
Ciprofloxacin ADME	R-HSA-9793528	9.385396e-01	0.028
Synthesis of IPs in the nucleus	R-HSA-1855191	9.385396e-01	0.028
Signal regulatory protein family interactions	R-HSA-391160	9.385396e-01	0.028
Acyl chain remodeling of CL	R-HSA-1482798	9.385396e-01	0.028
P2Y receptors	R-HSA-417957	9.385396e-01	0.028
Termination of O-glycan biosynthesis	R-HSA-977068	9.386305e-01	0.028
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.386305e-01	0.028
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.386305e-01	0.028
Transport to the Golgi and subsequent modification	R-HSA-948021	9.386544e-01	0.027
DNA Damage Bypass	R-HSA-73893	9.392674e-01	0.027
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.416810e-01	0.026
Citric acid cycle (TCA cycle)	R-HSA-71403	9.422023e-01	0.026
Protein ubiquitination	R-HSA-8852135	9.422023e-01	0.026
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.422023e-01	0.026
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.444827e-01	0.025
HIV Transcription Initiation	R-HSA-167161	9.444827e-01	0.025
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.444827e-01	0.025
Degradation of CRY and PER proteins	R-HSA-9932298	9.444827e-01	0.025
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.459654e-01	0.024
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.459654e-01	0.024
Thromboxane signalling through TP receptor	R-HSA-428930	9.459654e-01	0.024
Heme degradation	R-HSA-189483	9.463956e-01	0.024
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	9.473674e-01	0.023
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.473674e-01	0.023
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.473674e-01	0.023
Lysosphingolipid and LPA receptors	R-HSA-419408	9.473674e-01	0.023
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.473674e-01	0.023
FGFR3 ligand binding and activation	R-HSA-190239	9.473674e-01	0.023
Events associated with phagocytolytic activity of PMN cells	R-HSA-8941413	9.473674e-01	0.023
Protein repair	R-HSA-5676934	9.473674e-01	0.023
Unfolded Protein Response (UPR)	R-HSA-381119	9.479825e-01	0.023
Regulation of insulin secretion	R-HSA-422356	9.486500e-01	0.023
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.498051e-01	0.022
The phototransduction cascade	R-HSA-2514856	9.498051e-01	0.022
Hedgehog ligand biogenesis	R-HSA-5358346	9.498051e-01	0.022
Activation of GABAB receptors	R-HSA-991365	9.499207e-01	0.022
GABA B receptor activation	R-HSA-977444	9.499207e-01	0.022
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.510853e-01	0.022
Parasite infection	R-HSA-9664407	9.510853e-01	0.022
Leishmania phagocytosis	R-HSA-9664417	9.510853e-01	0.022
SARS-CoV-2-host interactions	R-HSA-9705683	9.515984e-01	0.022
Signaling by NOTCH2	R-HSA-1980145	9.521397e-01	0.021
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.521397e-01	0.021
eNOS activation	R-HSA-203615	9.521397e-01	0.021
Acyl chain remodelling of PS	R-HSA-1482801	9.524599e-01	0.021
Signaling by Insulin receptor	R-HSA-74752	9.526924e-01	0.021
Phospholipid metabolism	R-HSA-1483257	9.531500e-01	0.021
RNA Polymerase II Promoter Escape	R-HSA-73776	9.548653e-01	0.020
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.548653e-01	0.020
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	R-HSA-2142816	9.549276e-01	0.020
Class I peroxisomal membrane protein import	R-HSA-9603798	9.549276e-01	0.020
WNT5A-dependent internalization of FZD4	R-HSA-5099900	9.549276e-01	0.020
Attachment and Entry	R-HSA-9678110	9.549276e-01	0.020
Fructose catabolism	R-HSA-70350	9.549276e-01	0.020
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.549276e-01	0.020
ABC-family proteins mediated transport	R-HSA-382556	9.556355e-01	0.020
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.561609e-01	0.019
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.568071e-01	0.019
Transferrin endocytosis and recycling	R-HSA-917977	9.573045e-01	0.019
MET activates PTK2 signaling	R-HSA-8874081	9.582040e-01	0.019
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.582040e-01	0.019
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.582040e-01	0.019
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.582040e-01	0.019
Urea cycle	R-HSA-70635	9.582040e-01	0.019
Amino acids regulate mTORC1	R-HSA-9639288	9.586548e-01	0.018
SARS-CoV-2 Infection	R-HSA-9694516	9.588973e-01	0.018
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.614022e-01	0.017
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.614022e-01	0.017
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.614022e-01	0.017
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	9.614022e-01	0.017
Passive transport by Aquaporins	R-HSA-432047	9.614022e-01	0.017
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	9.614022e-01	0.017
Formation of xylulose-5-phosphate	R-HSA-5661270	9.614022e-01	0.017
Coenzyme A biosynthesis	R-HSA-196783	9.614022e-01	0.017
tRNA modification in the mitochondrion	R-HSA-6787450	9.614022e-01	0.017
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.614022e-01	0.017
Lysosome Vesicle Biogenesis	R-HSA-432720	9.619431e-01	0.017
FGFR2 mutant receptor activation	R-HSA-1839126	9.619431e-01	0.017
Glycosphingolipid transport	R-HSA-9845576	9.619431e-01	0.017
Interferon gamma signaling	R-HSA-877300	9.628944e-01	0.016
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.632793e-01	0.016
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.632793e-01	0.016
Signaling by BMP	R-HSA-201451	9.632793e-01	0.016
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.634300e-01	0.016
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.646749e-01	0.016
Paracetamol ADME	R-HSA-9753281	9.660534e-01	0.015
ER-Phagosome pathway	R-HSA-1236974	9.662651e-01	0.015
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.669471e-01	0.015
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.669471e-01	0.015
Catecholamine biosynthesis	R-HSA-209905	9.669471e-01	0.015
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.671216e-01	0.015
Insulin receptor recycling	R-HSA-77387	9.677593e-01	0.014
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.677593e-01	0.014
Cellular response to hypoxia	R-HSA-1234174	9.690657e-01	0.014
ROS and RNS production in phagocytes	R-HSA-1222556	9.694851e-01	0.013
Elastic fibre formation	R-HSA-1566948	9.698336e-01	0.013
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.704634e-01	0.013
G beta:gamma signalling through PLC beta	R-HSA-418217	9.716956e-01	0.012
Activated point mutants of FGFR2	R-HSA-2033519	9.716956e-01	0.012
FGFR1 ligand binding and activation	R-HSA-190242	9.716956e-01	0.012
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	R-HSA-2142670	9.716956e-01	0.012
Presynaptic function of Kainate receptors	R-HSA-500657	9.716956e-01	0.012
RNA Polymerase III Transcription Termination	R-HSA-73980	9.716956e-01	0.012
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.716956e-01	0.012
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.716956e-01	0.012
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.716956e-01	0.012
Post-translational protein phosphorylation	R-HSA-8957275	9.726104e-01	0.012
RAS processing	R-HSA-9648002	9.731721e-01	0.012
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.751919e-01	0.011
Neurotransmitter clearance	R-HSA-112311	9.751919e-01	0.011
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.757623e-01	0.011
Diseases of hemostasis	R-HSA-9671793	9.757623e-01	0.011
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.757623e-01	0.011
HDL remodeling	R-HSA-8964058	9.757623e-01	0.011
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.761579e-01	0.010
Hemostasis	R-HSA-109582	9.765874e-01	0.010
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.773210e-01	0.010
Antigen processing-Cross presentation	R-HSA-1236975	9.777116e-01	0.010
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.782572e-01	0.010
Extra-nuclear estrogen signaling	R-HSA-9009391	9.785288e-01	0.009
Interferon alpha/beta signaling	R-HSA-909733	9.787758e-01	0.009
ABC transporter disorders	R-HSA-5619084	9.788069e-01	0.009
Maturation of spike protein	R-HSA-9694548	9.788258e-01	0.009
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.792448e-01	0.009
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.792448e-01	0.009
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.792448e-01	0.009
Acyl chain remodelling of PI	R-HSA-1482922	9.792448e-01	0.009
Glycogen synthesis	R-HSA-3322077	9.792448e-01	0.009
Protein localization	R-HSA-9609507	9.803704e-01	0.009
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.822271e-01	0.008
FGFR2 ligand binding and activation	R-HSA-190241	9.822271e-01	0.008
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.822271e-01	0.008
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.822271e-01	0.008
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.822271e-01	0.008
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.822271e-01	0.008
Phenylalanine metabolism	R-HSA-8964208	9.822271e-01	0.008
Abacavir metabolism	R-HSA-2161541	9.822271e-01	0.008
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.822271e-01	0.008
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.822271e-01	0.008
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.829026e-01	0.007
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.833250e-01	0.007
Attachment and Entry	R-HSA-9694614	9.847811e-01	0.007
Molybdenum cofactor biosynthesis	R-HSA-947581	9.847811e-01	0.007
Ribavirin ADME	R-HSA-9755088	9.847811e-01	0.007
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.847811e-01	0.007
Serine metabolism	R-HSA-977347	9.847811e-01	0.007
Glutathione synthesis and recycling	R-HSA-174403	9.847811e-01	0.007
Neurotransmitter release cycle	R-HSA-112310	9.853809e-01	0.006
Acyl chain remodelling of PC	R-HSA-1482788	9.854080e-01	0.006
Glutamate and glutamine metabolism	R-HSA-8964539	9.854080e-01	0.006
SARS-CoV Infections	R-HSA-9679506	9.857748e-01	0.006
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.867550e-01	0.006
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.869681e-01	0.006
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	9.869681e-01	0.006
Ethanol oxidation	R-HSA-71384	9.869681e-01	0.006
Signal amplification	R-HSA-392518	9.872368e-01	0.006
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.872368e-01	0.006
RA biosynthesis pathway	R-HSA-5365859	9.872368e-01	0.006
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.872368e-01	0.006
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.873593e-01	0.006
G alpha (z) signalling events	R-HSA-418597	9.877812e-01	0.005
Regulation of PTEN mRNA translation	R-HSA-8943723	9.888410e-01	0.005
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.888410e-01	0.005
Formation of the ureteric bud	R-HSA-9830674	9.888410e-01	0.005
Biosynthesis of maresins	R-HSA-9018682	9.888410e-01	0.005
ABC transporters in lipid homeostasis	R-HSA-1369062	9.888410e-01	0.005
Acyl chain remodelling of PE	R-HSA-1482839	9.888415e-01	0.005
PERK regulates gene expression	R-HSA-381042	9.888415e-01	0.005
Metabolism of amine-derived hormones	R-HSA-209776	9.890890e-01	0.005
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.890911e-01	0.005
Viral Infection Pathways	R-HSA-9824446	9.901210e-01	0.004
CYP2E1 reactions	R-HSA-211999	9.904448e-01	0.004
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.904448e-01	0.004
Mitochondrial RNA degradation	R-HSA-9836573	9.904448e-01	0.004
TNFs bind their physiological receptors	R-HSA-5669034	9.904448e-01	0.004
PPARA activates gene expression	R-HSA-1989781	9.905327e-01	0.004
Collagen formation	R-HSA-1474290	9.907896e-01	0.004
Synthesis of PC	R-HSA-1483191	9.909308e-01	0.004
TRAF6 mediated IRF7 activation	R-HSA-933541	9.914820e-01	0.004
SLC-mediated transport of organic cations	R-HSA-549127	9.914820e-01	0.004
Alpha-oxidation of phytanate	R-HSA-389599	9.918182e-01	0.004
Fertilization	R-HSA-1187000	9.918182e-01	0.004
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.918182e-01	0.004
Laminin interactions	R-HSA-3000157	9.918182e-01	0.004
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.918512e-01	0.004
Plasma lipoprotein remodeling	R-HSA-8963899	9.919833e-01	0.003
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.929137e-01	0.003
Sphingolipid catabolism	R-HSA-9845614	9.929943e-01	0.003
Suppression of phagosomal maturation	R-HSA-9637687	9.929943e-01	0.003
RAB geranylgeranylation	R-HSA-8873719	9.931015e-01	0.003
Signaling by Retinoic Acid	R-HSA-5362517	9.931015e-01	0.003
Metabolism of polyamines	R-HSA-351202	9.931015e-01	0.003
Innate Immune System	R-HSA-168249	9.934257e-01	0.003
Pentose phosphate pathway	R-HSA-71336	9.935081e-01	0.003
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.936470e-01	0.003
Metabolism of cofactors	R-HSA-8978934	9.936470e-01	0.003
Triglyceride biosynthesis	R-HSA-75109	9.940013e-01	0.003
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.940013e-01	0.003
Maturation of hRSV A proteins	R-HSA-9828806	9.940013e-01	0.003
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.943073e-01	0.002
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.943274e-01	0.002
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.943358e-01	0.002
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.943358e-01	0.002
NCAM signaling for neurite out-growth	R-HSA-375165	9.945322e-01	0.002
Prednisone ADME	R-HSA-9757110	9.948637e-01	0.002
Iron assimilation using enterobactin	R-HSA-9638334	9.948637e-01	0.002
Pyrimidine salvage	R-HSA-73614	9.948637e-01	0.002
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.950597e-01	0.002
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.950724e-01	0.002
Thyroxine biosynthesis	R-HSA-209968	9.956021e-01	0.002
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.956021e-01	0.002
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.956021e-01	0.002
Glucagon-type ligand receptors	R-HSA-420092	9.956021e-01	0.002
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.956926e-01	0.002
Iron uptake and transport	R-HSA-917937	9.959167e-01	0.002
G alpha (q) signalling events	R-HSA-416476	9.961619e-01	0.002
Cytosolic tRNA aminoacylation	R-HSA-379716	9.962456e-01	0.002
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.966632e-01	0.001
Response of Mtb to phagocytosis	R-HSA-9637690	9.967287e-01	0.001
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.967758e-01	0.001
Molecules associated with elastic fibres	R-HSA-2129379	9.967758e-01	0.001
Nicotinate metabolism	R-HSA-196807	9.969679e-01	0.001
Metabolism of steroid hormones	R-HSA-196071	9.969679e-01	0.001
Surfactant metabolism	R-HSA-5683826	9.971506e-01	0.001
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.971506e-01	0.001
DAG1 glycosylations	R-HSA-8931838	9.972394e-01	0.001
O-linked glycosylation of mucins	R-HSA-913709	9.973089e-01	0.001
Dectin-2 family	R-HSA-5621480	9.974137e-01	0.001
Neddylation	R-HSA-8951664	9.974841e-01	0.001
Selenoamino acid metabolism	R-HSA-2408522	9.976325e-01	0.001
Recycling of bile acids and salts	R-HSA-159418	9.976364e-01	0.001
Regulation of pyruvate metabolism	R-HSA-9861718	9.978400e-01	0.001
Peroxisomal protein import	R-HSA-9033241	9.979979e-01	0.001
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.982673e-01	0.001
Peptide hormone metabolism	R-HSA-2980736	9.983143e-01	0.001
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.983939e-01	0.001
Collagen degradation	R-HSA-1442490	9.984524e-01	0.001
Endogenous sterols	R-HSA-211976	9.984524e-01	0.001
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.985165e-01	0.001
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.985165e-01	0.001
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.986961e-01	0.001
FCERI mediated MAPK activation	R-HSA-2871796	9.987182e-01	0.001
HS-GAG biosynthesis	R-HSA-2022928	9.987299e-01	0.001
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.987299e-01	0.001
Azathioprine ADME	R-HSA-9748787	9.987629e-01	0.001
NCAM1 interactions	R-HSA-419037	9.989126e-01	0.000
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.989126e-01	0.000
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.989126e-01	0.000
Collagen chain trimerization	R-HSA-8948216	9.989126e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.990770e-01	0.000
SLC transporter disorders	R-HSA-5619102	9.991556e-01	0.000
Nucleotide biosynthesis	R-HSA-8956320	9.991877e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.992018e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.992018e-01	0.000
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.992029e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.992911e-01	0.000
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.992943e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.992946e-01	0.000
rRNA processing in the mitochondrion	R-HSA-8868766	9.993176e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.993783e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.994621e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.994714e-01	0.000
Scavenging by Class A Receptors	R-HSA-3000480	9.994998e-01	0.000
Heme biosynthesis	R-HSA-189451	9.994998e-01	0.000
Synthesis of PA	R-HSA-1483166	9.995379e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.995456e-01	0.000
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.995718e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.995813e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.995813e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.995813e-01	0.000
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.996334e-01	0.000
Amino acid transport across the plasma membrane	R-HSA-352230	9.996519e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.996661e-01	0.000
Aspirin ADME	R-HSA-9749641	9.996788e-01	0.000
RSV-host interactions	R-HSA-9833110	9.996791e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.996827e-01	0.000
Methylation	R-HSA-156581	9.996862e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.996862e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.996980e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.997077e-01	0.000
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.997313e-01	0.000
Degradation of cysteine and homocysteine	R-HSA-1614558	9.997313e-01	0.000
tRNA processing	R-HSA-72306	9.997535e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.998029e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.998152e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.998152e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.998267e-01	0.000
Xenobiotics	R-HSA-211981	9.998291e-01	0.000
Integrin cell surface interactions	R-HSA-216083	9.998352e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.998363e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.998403e-01	0.000
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.998557e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.998557e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.998559e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998887e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.998899e-01	0.000
Complex IV assembly	R-HSA-9864848	9.998943e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999350e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999445e-01	0.000
Digestion	R-HSA-8935690	9.999514e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999530e-01	0.000
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.999695e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.999695e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999717e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999720e-01	0.000
Glutathione conjugation	R-HSA-156590	9.999739e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.999777e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999827e-01	0.000
Digestion and absorption	R-HSA-8963743	9.999836e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999836e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999858e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.999860e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.999860e-01	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999880e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999901e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999906e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999925e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999929e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999939e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999942e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999945e-01	0.000
Translation	R-HSA-72766	9.999948e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999953e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999954e-01	0.000
Purine catabolism	R-HSA-74259	9.999960e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999964e-01	0.000
FCGR activation	R-HSA-2029481	9.999981e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999983e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999984e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999987e-01	0.000
Disease	R-HSA-1643685	9.999988e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999989e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999989e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999990e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999990e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999994e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999994e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999996e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999996e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999997e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999997e-01	0.000
Infectious disease	R-HSA-5663205	9.999997e-01	0.000
Transport of small molecules	R-HSA-382551	9.999997e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999997e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999998e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999999e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Initial triggering of complement	R-HSA-166663	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cellular response to heat stress	R-HSA-3371556	1.110223e-16	15.955
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	2.886580e-15	14.540
Attenuation phase	R-HSA-3371568	1.265654e-13	12.898
HSF1-dependent transactivation	R-HSA-3371571	1.629807e-13	12.788
Cell Cycle	R-HSA-1640170	9.701129e-13	12.013
Cell Cycle, Mitotic	R-HSA-69278	2.885137e-12	11.540
HSF1 activation	R-HSA-3371511	2.558032e-11	10.592
M Phase	R-HSA-68886	2.421885e-11	10.616
Apoptotic execution phase	R-HSA-75153	1.016737e-08	7.993
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.219361e-08	7.654
Cellular Senescence	R-HSA-2559583	7.665589e-08	7.115
Cell-Cell communication	R-HSA-1500931	8.956748e-08	7.048
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.580616e-07	6.801
Separation of Sister Chromatids	R-HSA-2467813	2.671095e-07	6.573
Mitotic Anaphase	R-HSA-68882	3.118903e-07	6.506
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.525241e-07	6.453
Apoptotic cleavage of cellular proteins	R-HSA-111465	4.189351e-07	6.378
Mitotic Prometaphase	R-HSA-68877	4.472018e-07	6.349
Nervous system development	R-HSA-9675108	4.729272e-07	6.325
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	5.304738e-07	6.275
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.027990e-07	6.220
Cell junction organization	R-HSA-446728	6.480367e-07	6.188
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	7.390991e-07	6.131
Metabolism of RNA	R-HSA-8953854	9.628299e-07	6.016
Axon guidance	R-HSA-422475	9.858037e-07	6.006
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.643873e-06	5.784
Interleukin-12 signaling	R-HSA-9020591	1.800792e-06	5.745
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.995797e-06	5.700
Eukaryotic Translation Elongation	R-HSA-156842	2.068845e-06	5.684
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.438062e-06	5.613
Apoptosis	R-HSA-109581	2.949132e-06	5.530
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	3.275172e-06	5.485
Eukaryotic Translation Initiation	R-HSA-72613	3.798871e-06	5.420
Cap-dependent Translation Initiation	R-HSA-72737	3.798871e-06	5.420
L1CAM interactions	R-HSA-373760	3.798871e-06	5.420
Recycling pathway of L1	R-HSA-437239	3.899500e-06	5.409
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.782447e-06	5.320
Signaling by ALK in cancer	R-HSA-9700206	4.782447e-06	5.320
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	5.605751e-06	5.251
Interleukin-12 family signaling	R-HSA-447115	5.935894e-06	5.227
Membrane Trafficking	R-HSA-199991	7.650523e-06	5.116
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.009944e-06	5.096
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	9.989741e-06	5.000
Programmed Cell Death	R-HSA-5357801	1.035754e-05	4.985
Formation of a pool of free 40S subunits	R-HSA-72689	1.165185e-05	4.934
Influenza Infection	R-HSA-168255	1.153417e-05	4.938
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.280869e-05	4.892
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.280869e-05	4.892
ISG15 antiviral mechanism	R-HSA-1169408	1.399998e-05	4.854
Signaling by ROBO receptors	R-HSA-376176	1.597349e-05	4.797
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.606193e-05	4.794
Mitotic Prophase	R-HSA-68875	1.738164e-05	4.760
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.019847e-05	4.695
Peptide chain elongation	R-HSA-156902	1.994906e-05	4.700
Chaperone Mediated Autophagy	R-HSA-9613829	2.433637e-05	4.614
Metalloprotease DUBs	R-HSA-5689901	2.497416e-05	4.603
Aggrephagy	R-HSA-9646399	2.604309e-05	4.584
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.604309e-05	4.584
Cell-extracellular matrix interactions	R-HSA-446353	2.550859e-05	4.593
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.671269e-05	4.573
mRNA Splicing - Major Pathway	R-HSA-72163	2.759198e-05	4.559
Ribosomal scanning and start codon recognition	R-HSA-72702	3.067595e-05	4.513
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.258108e-05	4.487
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.394192e-05	4.469
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.465095e-05	4.460
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.798598e-05	4.420
Signaling by RAF1 mutants	R-HSA-9656223	4.238230e-05	4.373
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	4.757059e-05	4.323
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.744089e-05	4.241
Translation initiation complex formation	R-HSA-72649	6.469265e-05	4.189
Kinesins	R-HSA-983189	6.756841e-05	4.170
Adherens junctions interactions	R-HSA-418990	7.739253e-05	4.111
Downregulation of ERBB2 signaling	R-HSA-8863795	8.094617e-05	4.092
mRNA Splicing	R-HSA-72172	8.252865e-05	4.083
Cell Cycle Checkpoints	R-HSA-69620	9.750665e-05	4.011
Signal Transduction	R-HSA-162582	9.642829e-05	4.016
G2/M Transition	R-HSA-69275	1.086648e-04	3.964
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.138370e-04	3.944
Nuclear Envelope Breakdown	R-HSA-2980766	1.155300e-04	3.937
Signaling downstream of RAS mutants	R-HSA-9649948	1.280770e-04	3.893
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.280770e-04	3.893
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.280770e-04	3.893
Signaling by RAS mutants	R-HSA-6802949	1.280770e-04	3.893
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.319016e-04	3.880
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.313898e-04	3.881
Mitotic G2-G2/M phases	R-HSA-453274	1.319016e-04	3.880
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.389614e-04	3.857
Selective autophagy	R-HSA-9663891	1.407584e-04	3.852
Mitotic Spindle Checkpoint	R-HSA-69618	1.613393e-04	3.792
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.617517e-04	3.791
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.756536e-04	3.755
Regulation of PTEN gene transcription	R-HSA-8943724	1.986148e-04	3.702
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.921158e-04	3.716
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.910968e-04	3.719
Oncogenic MAPK signaling	R-HSA-6802957	2.003757e-04	3.698
Eukaryotic Translation Termination	R-HSA-72764	1.999830e-04	3.699
Cell-cell junction organization	R-HSA-421270	1.911602e-04	3.719
HIV Life Cycle	R-HSA-162587	1.993577e-04	3.700
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.158579e-04	3.666
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.214617e-04	3.655
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.234427e-04	3.651
Ribosome-associated quality control	R-HSA-9948299	2.296586e-04	3.639
PKR-mediated signaling	R-HSA-9833482	2.464775e-04	3.608
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	2.819499e-04	3.550
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.087734e-04	3.510
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.193612e-04	3.496
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.296564e-04	3.482
SARS-CoV-2-host interactions	R-HSA-9705683	3.514350e-04	3.454
Josephin domain DUBs	R-HSA-5689877	3.576435e-04	3.447
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.995110e-04	3.398
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.321613e-04	3.364
Selenocysteine synthesis	R-HSA-2408557	4.341950e-04	3.362
MAP2K and MAPK activation	R-HSA-5674135	4.682070e-04	3.330
Metabolism of non-coding RNA	R-HSA-194441	4.714271e-04	3.327
snRNP Assembly	R-HSA-191859	4.714271e-04	3.327
Meiotic synapsis	R-HSA-1221632	4.813266e-04	3.318
Oxidative Stress Induced Senescence	R-HSA-2559580	4.907307e-04	3.309
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.304910e-04	3.275
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.015612e-04	3.300
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	5.417444e-04	3.266
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	5.106529e-04	3.292
Chromatin organization	R-HSA-4839726	5.425026e-04	3.266
Viral mRNA Translation	R-HSA-192823	5.536018e-04	3.257
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	5.634550e-04	3.249
Chromatin modifying enzymes	R-HSA-3247509	5.641581e-04	3.249
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	5.721122e-04	3.243
Amplification of signal from the kinetochores	R-HSA-141424	5.721122e-04	3.243
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.804026e-04	3.236
FLT3 signaling by CBL mutants	R-HSA-9706377	7.187497e-04	3.143
HDACs deacetylate histones	R-HSA-3214815	6.746522e-04	3.171
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	7.164401e-04	3.145
Autophagy	R-HSA-9612973	7.447389e-04	3.128
HATs acetylate histones	R-HSA-3214847	7.795091e-04	3.108
Nonsense-Mediated Decay (NMD)	R-HSA-927802	7.866841e-04	3.104
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	7.866841e-04	3.104
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.939209e-04	3.100
NS1 Mediated Effects on Host Pathways	R-HSA-168276	8.095016e-04	3.092
Transcriptional Regulation by E2F6	R-HSA-8953750	8.095016e-04	3.092
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	8.247936e-04	3.084
Late endosomal microautophagy	R-HSA-9615710	8.627769e-04	3.064
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	8.731834e-04	3.059
SARS-CoV-1-host interactions	R-HSA-9692914	8.807575e-04	3.055
Regulation of CDH1 Function	R-HSA-9764561	9.306783e-04	3.031
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.053567e-03	2.977
Viral Infection Pathways	R-HSA-9824446	9.763507e-04	3.010
HIV Infection	R-HSA-162906	1.074145e-03	2.969
PTEN Regulation	R-HSA-6807070	1.093256e-03	2.961
Signaling by Interleukins	R-HSA-449147	1.097048e-03	2.960
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.152946e-03	2.938
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.190376e-03	2.924
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.334805e-03	2.875
Smooth Muscle Contraction	R-HSA-445355	1.334805e-03	2.875
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.358141e-03	2.867
PRC2 methylates histones and DNA	R-HSA-212300	1.401064e-03	2.854
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.413459e-03	2.850
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.674075e-03	2.776
Late Phase of HIV Life Cycle	R-HSA-162599	1.581373e-03	2.801
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.642497e-03	2.784
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.559009e-03	2.807
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.691687e-03	2.772
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.691687e-03	2.772
Clathrin-mediated endocytosis	R-HSA-8856828	1.729390e-03	2.762
Assembly of the pre-replicative complex	R-HSA-68867	1.732311e-03	2.761
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.744081e-03	2.758
HCMV Early Events	R-HSA-9609690	1.809577e-03	2.742
Cytokine Signaling in Immune system	R-HSA-1280215	1.858105e-03	2.731
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.869113e-03	2.728
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.936486e-03	2.713
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.952234e-03	2.709
Muscle contraction	R-HSA-397014	1.999127e-03	2.699
Intracellular signaling by second messengers	R-HSA-9006925	2.071292e-03	2.684
Interferon Signaling	R-HSA-913531	2.115113e-03	2.675
Striated Muscle Contraction	R-HSA-390522	2.427823e-03	2.615
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	2.298219e-03	2.639
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.381706e-03	2.623
Transport of connexons to the plasma membrane	R-HSA-190872	2.287489e-03	2.641
Deubiquitination	R-HSA-5688426	2.473792e-03	2.607
Macroautophagy	R-HSA-1632852	2.567175e-03	2.591
rRNA processing	R-HSA-72312	2.660355e-03	2.575
Meiosis	R-HSA-1500620	2.728172e-03	2.564
Platelet calcium homeostasis	R-HSA-418360	2.869205e-03	2.542
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.873533e-03	2.542
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.903479e-03	2.537
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	2.921271e-03	2.534
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.955506e-03	2.529
Regulation of PTEN localization	R-HSA-8948747	3.365919e-03	2.473
Cohesin Loading onto Chromatin	R-HSA-2470946	3.365919e-03	2.473
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.087979e-03	2.510
mRNA 3'-end processing	R-HSA-72187	3.018989e-03	2.520
Ub-specific processing proteases	R-HSA-5689880	3.348409e-03	2.475
PKMTs methylate histone lysines	R-HSA-3214841	3.390961e-03	2.470
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.401409e-03	2.468
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.010021e-03	2.521
Cellular response to starvation	R-HSA-9711097	3.222310e-03	2.492
Transcriptional regulation by small RNAs	R-HSA-5578749	3.010021e-03	2.521
Spry regulation of FGF signaling	R-HSA-1295596	3.087979e-03	2.510
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.427786e-03	2.465
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.489918e-03	2.457
Signaling by ERBB2	R-HSA-1227986	3.665708e-03	2.436
Negative regulation of MET activity	R-HSA-6807004	3.766370e-03	2.424
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.766370e-03	2.424
Nephrin family interactions	R-HSA-373753	3.766370e-03	2.424
Regulation of TP53 Activity	R-HSA-5633007	3.769366e-03	2.424
Post NMDA receptor activation events	R-HSA-438064	3.813457e-03	2.419
Negative regulation of MAPK pathway	R-HSA-5675221	3.981088e-03	2.400
Golgi-to-ER retrograde transport	R-HSA-8856688	3.982463e-03	2.400
Vesicle-mediated transport	R-HSA-5653656	4.001971e-03	2.398
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.048720e-03	2.393
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	4.048720e-03	2.393
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	4.048720e-03	2.393
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.048720e-03	2.393
Glycolysis	R-HSA-70171	4.058666e-03	2.392
Regulation of NF-kappa B signaling	R-HSA-9758274	4.069951e-03	2.390
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	4.212691e-03	2.375
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.212691e-03	2.375
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.212691e-03	2.375
RNA Polymerase II Transcription Termination	R-HSA-73856	4.177768e-03	2.379
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.758530e-03	2.323
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	4.212691e-03	2.375
Diseases of programmed cell death	R-HSA-9645723	4.246440e-03	2.372
Ovarian tumor domain proteases	R-HSA-5689896	4.901583e-03	2.310
Regulation of endogenous retroelements	R-HSA-9842860	4.935292e-03	2.307
Myoclonic epilepsy of Lafora	R-HSA-3785653	5.007189e-03	2.300
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	5.007189e-03	2.300
Gap junction trafficking and regulation	R-HSA-157858	5.008991e-03	2.300
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	5.096146e-03	2.293
DNA Replication Pre-Initiation	R-HSA-69002	5.220768e-03	2.282
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.373928e-03	2.270
Defective pyroptosis	R-HSA-9710421	5.408025e-03	2.267
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	5.426922e-03	2.265
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.497789e-03	2.260
IRAK1 recruits IKK complex	R-HSA-937039	5.497789e-03	2.260
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.497789e-03	2.260
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.497789e-03	2.260
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	5.757612e-03	2.240
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.893929e-03	2.230
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.893929e-03	2.230
IPs transport between nucleus and cytosol	R-HSA-1855170	6.009315e-03	2.221
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.009315e-03	2.221
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	6.040942e-03	2.219
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	6.090330e-03	2.215
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.091102e-03	2.215
Host Interactions of HIV factors	R-HSA-162909	6.181706e-03	2.209
RMTs methylate histone arginines	R-HSA-3214858	6.259859e-03	2.203
Gap junction trafficking	R-HSA-190828	6.259859e-03	2.203
Gap junction degradation	R-HSA-190873	7.147605e-03	2.146
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.320741e-03	2.135
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	7.511695e-03	2.124
AURKA Activation by TPX2	R-HSA-8854518	7.682744e-03	2.114
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	7.656918e-03	2.116
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.819844e-03	2.107
mTORC1-mediated signalling	R-HSA-166208	7.250893e-03	2.140
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.819844e-03	2.107
Regulation of TP53 Expression and Degradation	R-HSA-6806003	6.727117e-03	2.172
Signaling by Hippo	R-HSA-2028269	6.721974e-03	2.173
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	6.770746e-03	2.169
Interactions of Rev with host cellular proteins	R-HSA-177243	7.819844e-03	2.107
Signaling by TGFB family members	R-HSA-9006936	6.767856e-03	2.170
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	7.106641e-03	2.148
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.828708e-03	2.166
HCMV Infection	R-HSA-9609646	8.053391e-03	2.094
Nuclear import of Rev protein	R-HSA-180746	8.352842e-03	2.078
Regulation of TP53 Activity through Methylation	R-HSA-6804760	8.449163e-03	2.073
Negative feedback regulation of MAPK pathway	R-HSA-5674499	8.494336e-03	2.071
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	8.494336e-03	2.071
Maturation of protein E	R-HSA-9694493	8.494336e-03	2.071
Maturation of protein E	R-HSA-9683683	8.494336e-03	2.071
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.632731e-03	2.064
DNA methylation	R-HSA-5334118	8.732493e-03	2.059
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	8.830851e-03	2.054
S Phase	R-HSA-69242	8.904304e-03	2.050
Neutrophil degranulation	R-HSA-6798695	9.150188e-03	2.039
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	9.478494e-03	2.023
PIP3 activates AKT signaling	R-HSA-1257604	9.499019e-03	2.022
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	9.855826e-03	2.006
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	9.855826e-03	2.006
Pexophagy	R-HSA-9664873	9.855826e-03	2.006
Apoptosis induced DNA fragmentation	R-HSA-140342	9.855826e-03	2.006
Interleukin-37 signaling	R-HSA-9008059	1.034146e-02	1.985
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.041937e-02	1.982
UCH proteinases	R-HSA-5689603	1.046263e-02	1.980
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.065466e-02	1.972
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.065466e-02	1.972
SARS-CoV-2 Infection	R-HSA-9694516	1.086234e-02	1.964
tRNA processing in the nucleus	R-HSA-6784531	1.087739e-02	1.963
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.118122e-02	1.952
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.134181e-02	1.945
Regulation of TP53 Degradation	R-HSA-6804757	1.134181e-02	1.945
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.209390e-02	1.917
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.209390e-02	1.917
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.209390e-02	1.917
p75NTR signals via NF-kB	R-HSA-193639	1.209390e-02	1.917
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.215855e-02	1.915
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.215855e-02	1.915
Semaphorin interactions	R-HSA-373755	1.215855e-02	1.915
EGFR downregulation	R-HSA-182971	1.216358e-02	1.915
Budding and maturation of HIV virion	R-HSA-162588	1.216358e-02	1.915
Evasion by RSV of host interferon responses	R-HSA-9833109	1.216358e-02	1.915
Ion homeostasis	R-HSA-5578775	1.227766e-02	1.911
Signal transduction by L1	R-HSA-445144	1.284897e-02	1.891
Unfolded Protein Response (UPR)	R-HSA-381119	1.353611e-02	1.869
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.690347e-02	1.772
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.557732e-02	1.808
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.557732e-02	1.808
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.610903e-02	1.793
Prolonged ERK activation events	R-HSA-169893	1.517920e-02	1.819
Regulation of T cell activation by CD28 family	R-HSA-388841	1.734707e-02	1.761
NF-kB is activated and signals survival	R-HSA-209560	1.722573e-02	1.764
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.651059e-02	1.782
Negative regulation of FLT3	R-HSA-9706369	1.517920e-02	1.819
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.614002e-02	1.792
XBP1(S) activates chaperone genes	R-HSA-381038	1.480735e-02	1.830
Selenoamino acid metabolism	R-HSA-2408522	1.529437e-02	1.815
Nucleosome assembly	R-HSA-774815	1.753143e-02	1.756
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.753143e-02	1.756
RNA Polymerase I Promoter Opening	R-HSA-73728	1.779515e-02	1.750
Packaging Of Telomere Ends	R-HSA-171306	1.779515e-02	1.750
SARS-CoV Infections	R-HSA-9679506	1.799112e-02	1.745
DNA Double Strand Break Response	R-HSA-5693606	1.848872e-02	1.733
Assembly Of The HIV Virion	R-HSA-175474	1.869341e-02	1.728
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.877127e-02	1.727
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.877127e-02	1.727
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.906651e-02	1.720
SARS-CoV-1 Infection	R-HSA-9678108	1.930761e-02	1.714
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.954981e-02	1.709
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.977172e-02	1.704
Regulation of TNFR1 signaling	R-HSA-5357905	1.977172e-02	1.704
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.977172e-02	1.704
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.032939e-02	1.692
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.099556e-02	1.678
MAP kinase activation	R-HSA-450294	2.117767e-02	1.674
RAF activation	R-HSA-5673000	2.189740e-02	1.660
Signaling by MAP2K mutants	R-HSA-9652169	2.198941e-02	1.658
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.199621e-02	1.658
VLDLR internalisation and degradation	R-HSA-8866427	2.199621e-02	1.658
p75NTR recruits signalling complexes	R-HSA-209543	2.199621e-02	1.658
Glucose metabolism	R-HSA-70326	2.205251e-02	1.657
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	2.221663e-02	1.653
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	2.222208e-02	1.653
Transcriptional Regulation by VENTX	R-HSA-8853884	2.229772e-02	1.652
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.229772e-02	1.652
Signaling by VEGF	R-HSA-194138	2.361926e-02	1.627
Termination of translesion DNA synthesis	R-HSA-5656169	2.414329e-02	1.617
ROBO receptors bind AKAP5	R-HSA-9010642	2.419398e-02	1.616
Type I hemidesmosome assembly	R-HSA-446107	2.419398e-02	1.616
RSK activation	R-HSA-444257	2.419398e-02	1.616
Formation of annular gap junctions	R-HSA-196025	2.419398e-02	1.616
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.419398e-02	1.616
Downregulation of ERBB4 signaling	R-HSA-1253288	2.419398e-02	1.616
Modulation by Mtb of host immune system	R-HSA-9637628	2.419398e-02	1.616
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.425197e-02	1.615
Signaling by NOTCH3	R-HSA-9012852	2.425197e-02	1.615
IRE1alpha activates chaperones	R-HSA-381070	2.474785e-02	1.606
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.487589e-02	1.604
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.501757e-02	1.602
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.501757e-02	1.602
Oncogene Induced Senescence	R-HSA-2559585	2.501757e-02	1.602
Nucleotide Excision Repair	R-HSA-5696398	2.531884e-02	1.597
RNA Polymerase I Transcription	R-HSA-73864	2.562996e-02	1.591
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.618636e-02	1.582
Syndecan interactions	R-HSA-3000170	2.618636e-02	1.582
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.618636e-02	1.582
Manipulation of host energy metabolism	R-HSA-9636667	3.567564e-02	1.448
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.760717e-02	1.559
Regulation of signaling by CBL	R-HSA-912631	3.290737e-02	1.483
IKK complex recruitment mediated by RIP1	R-HSA-937041	3.290737e-02	1.483
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.060723e-02	1.514
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	3.060723e-02	1.514
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.689189e-02	1.570
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.228951e-02	1.491
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.857413e-02	1.544
Co-inhibition by PD-1	R-HSA-389948	3.039353e-02	1.517
Signaling by EGFR	R-HSA-177929	2.689189e-02	1.570
Rap1 signalling	R-HSA-392517	3.290737e-02	1.483
Ca-dependent events	R-HSA-111996	2.832962e-02	1.548
DNA Double-Strand Break Repair	R-HSA-5693532	3.505785e-02	1.455
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.178653e-02	1.498
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	3.392182e-02	1.470
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.290737e-02	1.483
Frs2-mediated activation	R-HSA-170968	2.755013e-02	1.560
MTOR signalling	R-HSA-165159	2.832962e-02	1.548
Cellular responses to mechanical stimuli	R-HSA-9855142	2.726933e-02	1.564
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.178653e-02	1.498
Switching of origins to a post-replicative state	R-HSA-69052	3.228951e-02	1.491
TCF dependent signaling in response to WNT	R-HSA-201681	3.031651e-02	1.518
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.217932e-02	1.492
DNA Replication	R-HSA-69306	3.505785e-02	1.455
TNF signaling	R-HSA-75893	2.689189e-02	1.570
G2/M Checkpoints	R-HSA-69481	2.701054e-02	1.568
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.993112e-02	1.524
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.689189e-02	1.570
Gene Silencing by RNA	R-HSA-211000	2.928788e-02	1.533
DNA Repair	R-HSA-73894	3.570873e-02	1.447
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.640031e-02	1.439
Death Receptor Signaling	R-HSA-73887	3.709759e-02	1.431
G-protein mediated events	R-HSA-112040	3.735754e-02	1.428
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	3.783848e-02	1.422
Protein ubiquitination	R-HSA-8852135	3.822948e-02	1.418
Centrosome maturation	R-HSA-380287	3.822948e-02	1.418
Glycogen synthesis	R-HSA-3322077	3.882637e-02	1.411
Response of endothelial cells to shear stress	R-HSA-9860931	3.889343e-02	1.410
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.942151e-02	1.404
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.062620e-02	1.391
2-LTR circle formation	R-HSA-164843	4.062620e-02	1.391
Signal attenuation	R-HSA-74749	4.062620e-02	1.391
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.065017e-02	1.391
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.073083e-02	1.390
Signaling by EGFR in Cancer	R-HSA-1643713	4.089105e-02	1.388
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	4.113677e-02	1.386
Protein methylation	R-HSA-8876725	4.113677e-02	1.386
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	4.127459e-02	1.384
Regulation of MECP2 expression and activity	R-HSA-9022692	4.127459e-02	1.384
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	4.127459e-02	1.384
Regulation of necroptotic cell death	R-HSA-5675482	4.127459e-02	1.384
RNA Polymerase I Promoter Clearance	R-HSA-73854	4.147525e-02	1.382
Regulation of PTEN stability and activity	R-HSA-8948751	4.170225e-02	1.380
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.170225e-02	1.380
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	4.183919e-02	1.378
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.187625e-02	1.378
MAPK family signaling cascades	R-HSA-5683057	4.279773e-02	1.369
PLC beta mediated events	R-HSA-112043	4.328241e-02	1.364
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.452626e-02	1.351
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.492534e-02	1.348
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.492534e-02	1.348
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.492534e-02	1.348
MAPK6/MAPK4 signaling	R-HSA-5687128	4.516805e-02	1.345
CDC6 association with the ORC:origin complex	R-HSA-68689	4.524026e-02	1.344
Platelet degranulation	R-HSA-114608	4.527032e-02	1.344
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	4.538155e-02	1.343
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.540289e-02	1.343
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	4.583012e-02	1.339
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.678378e-02	1.330
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.678378e-02	1.330
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.724610e-02	1.326
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.724610e-02	1.326
Epigenetic regulation of gene expression	R-HSA-212165	4.756604e-02	1.323
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.952532e-02	1.225
Regulation of TP53 Expression	R-HSA-6804754	5.952532e-02	1.225
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.952532e-02	1.225
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.952532e-02	1.225
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.952532e-02	1.225
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.952532e-02	1.225
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.952532e-02	1.225
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.952532e-02	1.225
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.952532e-02	1.225
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.952532e-02	1.225
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.952532e-02	1.225
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.952532e-02	1.225
Signaling by LTK in cancer	R-HSA-9842640	6.004709e-02	1.222
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.004709e-02	1.222
Signaling by APC mutants	R-HSA-4839744	5.072181e-02	1.295
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	5.072181e-02	1.295
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	5.072181e-02	1.295
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	5.072181e-02	1.295
Activation of RAC1	R-HSA-428540	6.206326e-02	1.207
Signaling by GSK3beta mutants	R-HSA-5339716	6.206326e-02	1.207
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	4.921160e-02	1.308
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.815415e-02	1.235
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.796376e-02	1.168
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	6.012485e-02	1.221
Dual Incision in GG-NER	R-HSA-5696400	5.227621e-02	1.282
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	5.051225e-02	1.297
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.828690e-02	1.316
Degradation of DVL	R-HSA-4641258	7.202628e-02	1.143
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.182878e-02	1.209
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.318394e-02	1.274
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.212494e-02	1.283
Regulation of mitotic cell cycle	R-HSA-453276	5.212494e-02	1.283
VEGFR2 mediated vascular permeability	R-HSA-5218920	5.051225e-02	1.297
DNA Damage Bypass	R-HSA-73893	5.839873e-02	1.234
Processing of DNA double-strand break ends	R-HSA-5693607	6.064554e-02	1.217
Integration of provirus	R-HSA-162592	6.206326e-02	1.207
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.051225e-02	1.297
Circadian clock	R-HSA-9909396	6.364963e-02	1.196
CaM pathway	R-HSA-111997	6.500285e-02	1.187
Calmodulin induced events	R-HSA-111933	6.500285e-02	1.187
MyD88-independent TLR4 cascade	R-HSA-166166	6.111753e-02	1.214
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.111753e-02	1.214
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	5.227621e-02	1.282
Degradation of GLI2 by the proteasome	R-HSA-5610783	5.598555e-02	1.252
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	5.598555e-02	1.252
SIRT1 negatively regulates rRNA expression	R-HSA-427359	7.202628e-02	1.143
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	7.099729e-02	1.149
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	7.099729e-02	1.149
Homology Directed Repair	R-HSA-5693538	6.712189e-02	1.173
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	5.403704e-02	1.267
Meiotic recombination	R-HSA-912446	6.980042e-02	1.156
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.815415e-02	1.235
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	5.258564e-02	1.279
TBC/RABGAPs	R-HSA-8854214	6.804657e-02	1.167
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.012485e-02	1.221
TCR signaling	R-HSA-202403	6.111753e-02	1.214
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.044665e-02	1.219
MyD88 dependent cascade initiated on endosome	R-HSA-975155	5.750161e-02	1.240
Gap junction assembly	R-HSA-190861	5.227621e-02	1.282
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.306959e-02	1.275
Interleukin-17 signaling	R-HSA-448424	4.810959e-02	1.318
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	5.952532e-02	1.225
CREB phosphorylation	R-HSA-199920	6.004709e-02	1.222
Signaling by AXIN mutants	R-HSA-4839735	6.206326e-02	1.207
Signaling by AMER1 mutants	R-HSA-4839748	6.206326e-02	1.207
Regulation of FZD by ubiquitination	R-HSA-4641263	6.796376e-02	1.168
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.319239e-02	1.274
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.012485e-02	1.221
Hedgehog 'off' state	R-HSA-5610787	5.141435e-02	1.289
COPI-mediated anterograde transport	R-HSA-6807878	6.762064e-02	1.170
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.636351e-02	1.249
Transcriptional regulation by RUNX3	R-HSA-8878159	7.198493e-02	1.143
Signaling by Hedgehog	R-HSA-5358351	5.868544e-02	1.231
Nef and signal transduction	R-HSA-164944	6.004709e-02	1.222
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	5.072181e-02	1.295
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.206326e-02	1.207
Glycogen storage diseases	R-HSA-3229121	6.796376e-02	1.168
Reproduction	R-HSA-1474165	5.702834e-02	1.244
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.815415e-02	1.235
MITF-M-regulated melanocyte development	R-HSA-9730414	5.892360e-02	1.230
FLT3 signaling in disease	R-HSA-9682385	6.500285e-02	1.187
Cleavage of the damaged purine	R-HSA-110331	7.202628e-02	1.143
p75 NTR receptor-mediated signalling	R-HSA-193704	4.809245e-02	1.318
Growth hormone receptor signaling	R-HSA-982772	6.896793e-02	1.161
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.227621e-02	1.282
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.289489e-02	1.137
RUNX3 regulates NOTCH signaling	R-HSA-8941856	7.462352e-02	1.127
Disorders of Nervous System Development	R-HSA-9697154	7.462352e-02	1.127
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	7.462352e-02	1.127
Pervasive developmental disorders	R-HSA-9005895	7.462352e-02	1.127
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.462352e-02	1.127
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.462352e-02	1.127
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.462352e-02	1.127
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.462352e-02	1.127
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.462352e-02	1.127
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	7.557868e-02	1.122
Neurexins and neuroligins	R-HSA-6794361	7.599420e-02	1.119
ESR-mediated signaling	R-HSA-8939211	7.618434e-02	1.118
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	7.681597e-02	1.115
IFNG signaling activates MAPKs	R-HSA-9732724	7.681597e-02	1.115
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	7.681597e-02	1.115
Uptake and function of diphtheria toxin	R-HSA-5336415	7.681597e-02	1.115
Transcriptional Regulation by TP53	R-HSA-3700989	7.761955e-02	1.110
Neurodegenerative Diseases	R-HSA-8863678	7.814818e-02	1.107
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	7.814818e-02	1.107
Ephrin signaling	R-HSA-3928664	7.863172e-02	1.104
PKA activation	R-HSA-163615	7.863172e-02	1.104
Polo-like kinase mediated events	R-HSA-156711	7.863172e-02	1.104
Platelet sensitization by LDL	R-HSA-432142	7.863172e-02	1.104
Chromosome Maintenance	R-HSA-73886	7.919487e-02	1.101
RIPK1-mediated regulated necrosis	R-HSA-5213460	7.949295e-02	1.100
Depurination	R-HSA-73927	7.949295e-02	1.100
Protein-protein interactions at synapses	R-HSA-6794362	7.972698e-02	1.098
Translation	R-HSA-72766	8.001802e-02	1.097
DAG and IP3 signaling	R-HSA-1489509	8.161742e-02	1.088
Estrogen-dependent gene expression	R-HSA-9018519	8.247964e-02	1.084
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.256829e-02	1.083
EPH-Ephrin signaling	R-HSA-2682334	8.321718e-02	1.080
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.351976e-02	1.078
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.351976e-02	1.078
Synthesis of DNA	R-HSA-69239	8.387611e-02	1.076
Diseases of mitotic cell cycle	R-HSA-9675126	8.410151e-02	1.075
G alpha (12/13) signalling events	R-HSA-416482	8.666786e-02	1.062
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	8.734062e-02	1.059
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	8.734062e-02	1.059
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	8.734062e-02	1.059
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.740278e-02	1.058
Stabilization of p53	R-HSA-69541	8.740278e-02	1.058
MHC class II antigen presentation	R-HSA-2132295	8.799685e-02	1.056
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	8.836069e-02	1.054
Condensation of Prophase Chromosomes	R-HSA-2299718	8.897276e-02	1.051
Translesion Synthesis by POLH	R-HSA-110320	9.014172e-02	1.045
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.014172e-02	1.045
Interferon alpha/beta signaling	R-HSA-909733	9.083005e-02	1.042
Extra-nuclear estrogen signaling	R-HSA-9009391	9.128818e-02	1.040
Mitotic G1 phase and G1/S transition	R-HSA-453279	9.207654e-02	1.036
Sensory processing of sound	R-HSA-9659379	9.255125e-02	1.034
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.315116e-02	1.031
Loss of Function of TP53 in Cancer	R-HSA-9723907	9.346117e-02	1.029
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	9.346117e-02	1.029
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.346117e-02	1.029
Signaling by MRAS-complex mutants	R-HSA-9660537	9.538871e-02	1.021
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	9.538871e-02	1.021
Signaling by PTK6	R-HSA-8848021	9.568422e-02	1.019
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	9.568422e-02	1.019
Generation of second messenger molecules	R-HSA-202433	9.575373e-02	1.019
Glycogen metabolism	R-HSA-8982491	9.575373e-02	1.019
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.575373e-02	1.019
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.656656e-02	1.015
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.670721e-02	1.015
RAF/MAP kinase cascade	R-HSA-5673001	9.700313e-02	1.013
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	9.845831e-02	1.007
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.845831e-02	1.007
Adaptive Immune System	R-HSA-1280218	9.915873e-02	1.004
HCMV Late Events	R-HSA-9610379	1.016445e-01	0.993
Ion transport by P-type ATPases	R-HSA-936837	1.026841e-01	0.988
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	1.027213e-01	0.988
Regulation of KIT signaling	R-HSA-1433559	1.032201e-01	0.986
NRIF signals cell death from the nucleus	R-HSA-205043	1.032201e-01	0.986
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.040869e-01	0.983
NRAGE signals death through JNK	R-HSA-193648	1.040869e-01	0.983
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.045419e-01	0.981
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.045419e-01	0.981
Opioid Signalling	R-HSA-111885	1.077321e-01	0.968
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.077321e-01	0.968
Platelet activation, signaling and aggregation	R-HSA-76002	1.081803e-01	0.966
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.095640e-01	0.960
Interaction between L1 and Ankyrins	R-HSA-445095	1.095640e-01	0.960
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.128030e-01	0.948
Mitophagy	R-HSA-5205647	1.128030e-01	0.948
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.128030e-01	0.948
Signaling by NOTCH2	R-HSA-1980145	1.128030e-01	0.948
Degradation of CDH1	R-HSA-9766229	1.133025e-01	0.946
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.133025e-01	0.946
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.137614e-01	0.944
G2/M DNA damage checkpoint	R-HSA-69473	1.146978e-01	0.940
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.153423e-01	0.938
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.155880e-01	0.937
Lipophagy	R-HSA-9613354	1.155880e-01	0.937
ALK mutants bind TKIs	R-HSA-9700645	1.155880e-01	0.937
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.155880e-01	0.937
Regulation of CDH11 gene transcription	R-HSA-9762293	1.155880e-01	0.937
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.155880e-01	0.937
Butyrophilin (BTN) family interactions	R-HSA-8851680	1.155880e-01	0.937
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.155885e-01	0.937
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.155885e-01	0.937
ERK/MAPK targets	R-HSA-198753	1.155885e-01	0.937
Early Phase of HIV Life Cycle	R-HSA-162594	1.155885e-01	0.937
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.781923e-01	0.749
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.781923e-01	0.749
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.781923e-01	0.749
Diseases of Telomere Maintenance	R-HSA-9673013	1.781923e-01	0.749
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.781923e-01	0.749
TICAM1 deficiency - HSE	R-HSA-5602566	1.781923e-01	0.749
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.781923e-01	0.749
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.781923e-01	0.749
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.781923e-01	0.749
Hereditary fructose intolerance	R-HSA-5657560	1.781923e-01	0.749
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.781923e-01	0.749
Regulation of gap junction activity	R-HSA-191650	1.181729e-01	0.927
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.181729e-01	0.927
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.181729e-01	0.927
IRS activation	R-HSA-74713	1.512161e-01	0.820
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.512161e-01	0.820
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	1.857882e-01	0.731
IkBA variant leads to EDA-ID	R-HSA-5603029	1.857882e-01	0.731
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	1.857882e-01	0.731
Autointegration results in viral DNA circles	R-HSA-177539	2.213153e-01	0.655
PECAM1 interactions	R-HSA-210990	1.601076e-01	0.796
Beta-catenin phosphorylation cascade	R-HSA-196299	1.191366e-01	0.924
Translesion synthesis by POLI	R-HSA-5656121	1.360363e-01	0.866
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.360363e-01	0.866
Phosphorylation of the APC/C	R-HSA-176412	1.360363e-01	0.866
ERKs are inactivated	R-HSA-202670	1.840410e-01	0.735
Translesion synthesis by POLK	R-HSA-5655862	1.538388e-01	0.813
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.088365e-01	0.680
Elevation of cytosolic Ca2+ levels	R-HSA-139853	1.724585e-01	0.763
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	1.724585e-01	0.763
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.724585e-01	0.763
FGFR2 alternative splicing	R-HSA-6803529	1.440466e-01	0.841
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.440466e-01	0.841
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.233848e-01	0.909
Deadenylation of mRNA	R-HSA-429947	1.751800e-01	0.757
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.117934e-01	0.674
Polymerase switching on the C-strand of the telomere	R-HSA-174411	1.916291e-01	0.718
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.323272e-01	0.634
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.323272e-01	0.634
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.323272e-01	0.634
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.323272e-01	0.634
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.323272e-01	0.634
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.323272e-01	0.634
Processive synthesis on the C-strand of the telomere	R-HSA-174414	2.260291e-01	0.646
EPHA-mediated growth cone collapse	R-HSA-3928663	2.260291e-01	0.646
Cristae formation	R-HSA-8949613	2.260291e-01	0.646
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	1.409350e-01	0.851
Orc1 removal from chromatin	R-HSA-68949	1.409350e-01	0.851
Formation of RNA Pol II elongation complex	R-HSA-112382	1.409350e-01	0.851
RNA Polymerase I Promoter Escape	R-HSA-73772	1.409350e-01	0.851
mRNA Splicing - Minor Pathway	R-HSA-72165	1.660036e-01	0.780
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.508470e-01	0.821
Regulation of RAS by GAPs	R-HSA-5658442	2.143608e-01	0.669
Post-translational protein phosphorylation	R-HSA-8957275	1.239478e-01	0.907
Dual incision in TC-NER	R-HSA-6782135	2.051908e-01	0.688
Telomere Maintenance	R-HSA-157579	1.175228e-01	0.930
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	1.724585e-01	0.763
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.088365e-01	0.680
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	2.260291e-01	0.646
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.508470e-01	0.821
SWI/SNF chromatin remodelers	R-HSA-9932451	1.916291e-01	0.718
ATP-dependent chromatin remodelers	R-HSA-9932444	1.916291e-01	0.718
Chaperonin-mediated protein folding	R-HSA-390466	1.561958e-01	0.806
Regulation of the apoptosome activity	R-HSA-9627069	1.372254e-01	0.863
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.840410e-01	0.735
Disorders of Developmental Biology	R-HSA-9675151	1.538388e-01	0.813
Formation of apoptosome	R-HSA-111458	1.372254e-01	0.863
Translesion synthesis by REV1	R-HSA-110312	1.191366e-01	0.924
Regulation of IFNA/IFNB signaling	R-HSA-912694	1.440466e-01	0.841
Regulation of Apoptosis	R-HSA-169911	1.233848e-01	0.909
Protein folding	R-HSA-391251	1.354296e-01	0.868
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.473381e-01	0.832
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.981489e-01	0.703
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.840410e-01	0.735
Regulation of IFNG signaling	R-HSA-877312	2.088365e-01	0.680
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.212809e-01	0.916
Vif-mediated degradation of APOBEC3G	R-HSA-180585	1.344527e-01	0.871
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.624529e-01	0.789
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.017905e-01	0.695
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.017905e-01	0.695
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.840410e-01	0.735
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.260291e-01	0.646
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.374125e-01	0.862
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.374125e-01	0.862
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.374125e-01	0.862
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.374125e-01	0.862
NoRC negatively regulates rRNA expression	R-HSA-427413	1.597091e-01	0.797
MAPK1/MAPK3 signaling	R-HSA-5684996	1.211999e-01	0.916
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.881754e-01	0.725
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.213149e-01	0.916
Activation of NF-kappaB in B cells	R-HSA-1169091	2.272200e-01	0.644
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.464595e-01	0.834
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.464595e-01	0.834
Effects of PIP2 hydrolysis	R-HSA-114508	2.030144e-01	0.692
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.964517e-01	0.707
Hh mutants are degraded by ERAD	R-HSA-5362768	1.964517e-01	0.707
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.624529e-01	0.789
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.295699e-01	0.639
G1/S DNA Damage Checkpoints	R-HSA-69615	1.656620e-01	0.781
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.088365e-01	0.680
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.182776e-01	0.661
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.857882e-01	0.731
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	1.857882e-01	0.731
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.601076e-01	0.796
Signalling to ERKs	R-HSA-187687	1.233848e-01	0.909
G0 and Early G1	R-HSA-1538133	1.737865e-01	0.760
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.254326e-01	0.902
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.213153e-01	0.655
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.323272e-01	0.634
Asymmetric localization of PCP proteins	R-HSA-4608870	1.547750e-01	0.810
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.374125e-01	0.862
Signaling by NOTCH1	R-HSA-1980143	2.083499e-01	0.681
Signaling by WNT	R-HSA-195721	2.150382e-01	0.667
Mismatch Repair	R-HSA-5358508	1.918069e-01	0.717
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.335876e-01	0.874
Rab regulation of trafficking	R-HSA-9007101	1.532622e-01	0.815
Inhibition of PKR	R-HSA-169131	1.781923e-01	0.749
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.181729e-01	0.927
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.213153e-01	0.655
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	2.088365e-01	0.680
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	1.918069e-01	0.717
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.182555e-01	0.661
Sema4D in semaphorin signaling	R-HSA-400685	1.916291e-01	0.718
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	1.191366e-01	0.924
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.547750e-01	0.810
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.547750e-01	0.810
Platelet homeostasis	R-HSA-418346	1.904586e-01	0.720
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.180888e-01	0.928
Interleukin-1 family signaling	R-HSA-446652	1.718857e-01	0.765
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.538388e-01	0.813
Co-stimulation by CD28	R-HSA-389356	1.895285e-01	0.722
Hedgehog 'on' state	R-HSA-5632684	1.597091e-01	0.797
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.857882e-01	0.731
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.857882e-01	0.731
Vpu mediated degradation of CD4	R-HSA-180534	2.030144e-01	0.692
Cyclin E associated events during G1/S transition	R-HSA-69202	1.507322e-01	0.822
Hedgehog ligand biogenesis	R-HSA-5358346	2.272200e-01	0.644
Calnexin/calreticulin cycle	R-HSA-901042	2.182555e-01	0.661
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.313871e-01	0.636
Immune System	R-HSA-168256	1.374016e-01	0.862
G1/S Transition	R-HSA-69206	1.536016e-01	0.814
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.881796e-01	0.725
Signaling by NOTCH	R-HSA-157118	1.180873e-01	0.928
Potential therapeutics for SARS	R-HSA-9679191	2.220497e-01	0.654
Developmental Biology	R-HSA-1266738	2.111060e-01	0.675
Regulated Necrosis	R-HSA-5218859	1.335882e-01	0.874
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.213153e-01	0.655
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.360363e-01	0.866
NOD1/2 Signaling Pathway	R-HSA-168638	2.182555e-01	0.661
Viral Messenger RNA Synthesis	R-HSA-168325	1.465303e-01	0.834
Gluconeogenesis	R-HSA-70263	1.895285e-01	0.722
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.234046e-01	0.909
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.191366e-01	0.924
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.972518e-01	0.705
Base Excision Repair	R-HSA-73884	1.814863e-01	0.741
Signaling by PDGFR in disease	R-HSA-9671555	1.294606e-01	0.888
Signaling by NOTCH4	R-HSA-9013694	1.881754e-01	0.725
Amyloid fiber formation	R-HSA-977225	1.712666e-01	0.766
Signaling by FGFR2	R-HSA-5654738	1.624529e-01	0.789
Signaling by MET	R-HSA-6806834	1.624529e-01	0.789
ER Quality Control Compartment (ERQC)	R-HSA-901032	2.260291e-01	0.646
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.507322e-01	0.822
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.538388e-01	0.813
Response of Mtb to phagocytosis	R-HSA-9637690	1.334622e-01	0.875
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.918069e-01	0.717
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	1.873933e-01	0.727
Regulation of BACH1 activity	R-HSA-9708530	1.360363e-01	0.866
FLT3 Signaling	R-HSA-9607240	1.964517e-01	0.707
Cleavage of the damaged pyrimidine	R-HSA-110329	1.234046e-01	0.909
Depyrimidination	R-HSA-73928	1.234046e-01	0.909
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.338662e-01	0.631
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.343115e-01	0.630
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.343115e-01	0.630
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.343115e-01	0.630
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.343115e-01	0.630
Interleukin-6 signaling	R-HSA-1059683	2.343115e-01	0.630
CD28 dependent Vav1 pathway	R-HSA-389359	2.343115e-01	0.630
Hh mutants abrogate ligand secretion	R-HSA-5387390	2.381755e-01	0.623
Signaling by FGFR4	R-HSA-5654743	2.381755e-01	0.623
Transcriptional regulation by RUNX2	R-HSA-8878166	2.400881e-01	0.620
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	2.403478e-01	0.619
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.410030e-01	0.618
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.410030e-01	0.618
Infectious disease	R-HSA-5663205	2.416443e-01	0.617
Cilium Assembly	R-HSA-5617833	2.464622e-01	0.608
Triglyceride catabolism	R-HSA-163560	2.498090e-01	0.602
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.518065e-01	0.599
EPHB-mediated forward signaling	R-HSA-3928662	2.526845e-01	0.597
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.526845e-01	0.597
Netrin-1 signaling	R-HSA-373752	2.526845e-01	0.597
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	2.533177e-01	0.596
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.533177e-01	0.596
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.533177e-01	0.596
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.533177e-01	0.596
Heme signaling	R-HSA-9707616	2.535893e-01	0.596
IKBKB deficiency causes SCID	R-HSA-5602636	2.550085e-01	0.593
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.550085e-01	0.593
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.550085e-01	0.593
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.550085e-01	0.593
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	2.550085e-01	0.593
TRAF3 deficiency - HSE	R-HSA-5602571	2.550085e-01	0.593
PTEN Loss of Function in Cancer	R-HSA-5674404	2.550085e-01	0.593
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	2.550085e-01	0.593
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.550085e-01	0.593
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.550085e-01	0.593
Transport of connexins along the secretory pathway	R-HSA-190827	2.550085e-01	0.593
Breakdown of the nuclear lamina	R-HSA-352238	2.550085e-01	0.593
Oligomerization of connexins into connexons	R-HSA-190704	2.550085e-01	0.593
MECP2 regulates transcription factors	R-HSA-9022707	2.573172e-01	0.590
SOS-mediated signalling	R-HSA-112412	2.573172e-01	0.590
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	2.573172e-01	0.590
Cation-coupled Chloride cotransporters	R-HSA-426117	2.573172e-01	0.590
RUNX3 regulates WNT signaling	R-HSA-8951430	2.573172e-01	0.590
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.573172e-01	0.590
CHL1 interactions	R-HSA-447041	2.573172e-01	0.590
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.573172e-01	0.590
ER-Phagosome pathway	R-HSA-1236974	2.599906e-01	0.585
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.602924e-01	0.585
Malate-aspartate shuttle	R-HSA-9856872	2.602924e-01	0.585
DARPP-32 events	R-HSA-180024	2.620664e-01	0.582
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.620664e-01	0.582
Gene expression (Transcription)	R-HSA-74160	2.623866e-01	0.581
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.645338e-01	0.578
Degradation of AXIN	R-HSA-4641257	2.660459e-01	0.575
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	2.660459e-01	0.575
Base-Excision Repair, AP Site Formation	R-HSA-73929	2.673244e-01	0.573
Fanconi Anemia Pathway	R-HSA-6783310	2.674480e-01	0.573
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	2.674480e-01	0.573
Defective CFTR causes cystic fibrosis	R-HSA-5678895	2.674480e-01	0.573
Signaling by FGFR3	R-HSA-5654741	2.674480e-01	0.573
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	2.705985e-01	0.568
ER to Golgi Anterograde Transport	R-HSA-199977	2.727700e-01	0.564
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.746761e-01	0.561
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.746761e-01	0.561
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.746761e-01	0.561
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.746761e-01	0.561
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.746761e-01	0.561
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.746761e-01	0.561
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.761364e-01	0.559
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.790826e-01	0.554
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.805606e-01	0.552
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.805606e-01	0.552
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.805606e-01	0.552
Activation of BH3-only proteins	R-HSA-114452	2.805606e-01	0.552
Signaling by NTRKs	R-HSA-166520	2.811744e-01	0.551
Transcriptional Regulation by MECP2	R-HSA-8986944	2.816235e-01	0.550
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.816235e-01	0.550
Organelle biogenesis and maintenance	R-HSA-1852241	2.847118e-01	0.546
Processive synthesis on the lagging strand	R-HSA-69183	2.866165e-01	0.543
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.866165e-01	0.543
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.866165e-01	0.543
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.866165e-01	0.543
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.866165e-01	0.543
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.866165e-01	0.543
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.866165e-01	0.543
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.866165e-01	0.543
DCC mediated attractive signaling	R-HSA-418885	2.866165e-01	0.543
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	2.900604e-01	0.538
Cellular response to hypoxia	R-HSA-1234174	2.920925e-01	0.534
Developmental Cell Lineages	R-HSA-9734767	2.927132e-01	0.534
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.933952e-01	0.533
phospho-PLA2 pathway	R-HSA-111995	2.933952e-01	0.533
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	2.933952e-01	0.533
Adrenoceptors	R-HSA-390696	2.933952e-01	0.533
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	2.943932e-01	0.531
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.951179e-01	0.530
RAF-independent MAPK1/3 activation	R-HSA-112409	2.963162e-01	0.528
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.963162e-01	0.528
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.963162e-01	0.528
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.976251e-01	0.526
Plasma lipoprotein clearance	R-HSA-8964043	2.992487e-01	0.524
Signaling by ALK	R-HSA-201556	2.992487e-01	0.524
Trafficking of AMPA receptors	R-HSA-399719	2.992986e-01	0.524
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.992986e-01	0.524
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.131324e-01	0.504
WNT5A-dependent internalization of FZD4	R-HSA-5099900	3.131324e-01	0.504
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	3.131324e-01	0.504
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.131324e-01	0.504
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.161382e-01	0.500
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	3.181545e-01	0.497
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	3.204971e-01	0.494
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.246487e-01	0.489
Regulation of cortical dendrite branching	R-HSA-8985801	3.246487e-01	0.489
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.246487e-01	0.489
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.246487e-01	0.489
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.246487e-01	0.489
Toll-like Receptor Cascades	R-HSA-168898	3.264414e-01	0.486
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	3.284790e-01	0.483
ARMS-mediated activation	R-HSA-170984	3.292208e-01	0.483
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.292208e-01	0.483
AKT phosphorylates targets in the nucleus	R-HSA-198693	3.292208e-01	0.483
MAPK1 (ERK2) activation	R-HSA-112411	3.292208e-01	0.483
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	3.292208e-01	0.483
Calcineurin activates NFAT	R-HSA-2025928	3.292208e-01	0.483
Cellular response to mitochondrial stress	R-HSA-9840373	3.292208e-01	0.483
GP1b-IX-V activation signalling	R-HSA-430116	3.292208e-01	0.483
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.292208e-01	0.483
Respiratory syncytial virus genome replication	R-HSA-9834752	3.292208e-01	0.483
Integrin signaling	R-HSA-354192	3.372919e-01	0.472
Nuclear RNA decay	R-HSA-9930044	3.372919e-01	0.472
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.372919e-01	0.472
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.372919e-01	0.472
Extension of Telomeres	R-HSA-180786	3.379516e-01	0.471
Deadenylation-dependent mRNA decay	R-HSA-429914	3.379516e-01	0.471
PCP/CE pathway	R-HSA-4086400	3.388178e-01	0.470
Acetylcholine regulates insulin secretion	R-HSA-399997	3.397010e-01	0.469
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.401116e-01	0.468
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	3.401116e-01	0.468
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.498670e-01	0.456
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	3.503054e-01	0.456
Degradation of CRY and PER proteins	R-HSA-9932298	3.503054e-01	0.456
Translation of Structural Proteins	R-HSA-9683701	3.503054e-01	0.456
Long-term potentiation	R-HSA-9620244	3.621118e-01	0.441
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.621118e-01	0.441
HDMs demethylate histones	R-HSA-3214842	3.621118e-01	0.441
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.621118e-01	0.441
TGFBR3 expression	R-HSA-9839394	3.621118e-01	0.441
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.645261e-01	0.438
Folding of actin by CCT/TriC	R-HSA-390450	3.645261e-01	0.438
EGFR Transactivation by Gastrin	R-HSA-2179392	3.645261e-01	0.438
Regulation of CDH11 function	R-HSA-9762292	3.645261e-01	0.438
PI3K/AKT activation	R-HSA-198203	3.645261e-01	0.438
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.645261e-01	0.438
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	3.645261e-01	0.438
MET activates RAP1 and RAC1	R-HSA-8875555	3.645261e-01	0.438
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.645261e-01	0.438
Signaling by Leptin	R-HSA-2586552	3.645261e-01	0.438
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.661957e-01	0.436
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.661957e-01	0.436
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.661957e-01	0.436
Uptake and function of anthrax toxins	R-HSA-5210891	3.661957e-01	0.436
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.675102e-01	0.435
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.727045e-01	0.429
Cardiac conduction	R-HSA-5576891	3.727985e-01	0.429
Uptake and actions of bacterial toxins	R-HSA-5339562	3.755356e-01	0.425
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	3.756333e-01	0.425
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.756333e-01	0.425
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.756333e-01	0.425
Transcriptional regulation by RUNX1	R-HSA-8878171	3.782809e-01	0.422
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.840842e-01	0.416
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	3.840842e-01	0.416
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	3.840842e-01	0.416
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	3.840842e-01	0.416
Suppression of phagosomal maturation	R-HSA-9637687	3.840842e-01	0.416
Signaling by FGFR	R-HSA-190236	3.842394e-01	0.415
Signaling by SCF-KIT	R-HSA-1433557	3.847486e-01	0.415
MITF-M-dependent gene expression	R-HSA-9856651	3.861545e-01	0.413
trans-Golgi Network Vesicle Budding	R-HSA-199992	3.863980e-01	0.413
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.877827e-01	0.411
Defective CYP1B1 causes Glaucoma	R-HSA-5579000	3.877827e-01	0.411
Defective ABCC2 causes DJS	R-HSA-5679001	3.877827e-01	0.411
MET interacts with TNS proteins	R-HSA-8875513	3.877827e-01	0.411
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.877827e-01	0.411
Histamine receptors	R-HSA-390650	3.877827e-01	0.411
Ion channel transport	R-HSA-983712	3.908457e-01	0.408
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.925024e-01	0.406
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.925024e-01	0.406
PKA activation in glucagon signalling	R-HSA-164378	3.925024e-01	0.406
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.925024e-01	0.406
Apoptotic factor-mediated response	R-HSA-111471	3.925024e-01	0.406
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.925024e-01	0.406
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.948134e-01	0.404
Cellular response to chemical stress	R-HSA-9711123	3.957059e-01	0.403
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.962691e-01	0.402
rRNA modification in the nucleus and cytosol	R-HSA-6790901	3.962691e-01	0.402
Antigen processing-Cross presentation	R-HSA-1236975	3.981322e-01	0.400
RHOBTB3 ATPase cycle	R-HSA-9706019	3.990955e-01	0.399
Formation of the posterior neural plate	R-HSA-9832991	3.990955e-01	0.399
CD163 mediating an anti-inflammatory response	R-HSA-9662834	3.990955e-01	0.399
Synthesis of PI	R-HSA-1483226	3.990955e-01	0.399
Suppression of apoptosis	R-HSA-9635465	3.990955e-01	0.399
ChREBP activates metabolic gene expression	R-HSA-163765	3.990955e-01	0.399
ABC-family proteins mediated transport	R-HSA-382556	4.076944e-01	0.390
Signaling by ERBB4	R-HSA-1236394	4.138483e-01	0.383
G1/S-Specific Transcription	R-HSA-69205	4.139395e-01	0.383
RET signaling	R-HSA-8853659	4.139395e-01	0.383
The NLRP3 inflammasome	R-HSA-844456	4.185191e-01	0.378
E2F mediated regulation of DNA replication	R-HSA-113510	4.185191e-01	0.378
Maturation of nucleoprotein	R-HSA-9694631	4.185191e-01	0.378
Pre-NOTCH Processing in Golgi	R-HSA-1912420	4.185191e-01	0.378
STING mediated induction of host immune responses	R-HSA-1834941	4.185191e-01	0.378
Interleukin-1 signaling	R-HSA-9020702	4.194458e-01	0.377
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.240091e-01	0.373
Telomere Extension By Telomerase	R-HSA-171319	4.276847e-01	0.369
HIV elongation arrest and recovery	R-HSA-167287	4.276847e-01	0.369
Pausing and recovery of HIV elongation	R-HSA-167290	4.276847e-01	0.369
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	4.276847e-01	0.369
Transmission across Chemical Synapses	R-HSA-112315	4.307416e-01	0.366
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.327582e-01	0.364
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.327582e-01	0.364
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.327582e-01	0.364
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.327582e-01	0.364
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.327582e-01	0.364
Sodium/Calcium exchangers	R-HSA-425561	4.327582e-01	0.364
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	4.336019e-01	0.363
Class I MHC mediated antigen processing & presentation	R-HSA-983169	4.351290e-01	0.361
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	4.363339e-01	0.360
Regulation of pyruvate metabolism	R-HSA-9861718	4.363339e-01	0.360
Diseases of DNA repair	R-HSA-9675135	4.363339e-01	0.360
Signaling by FGFR1	R-HSA-5654736	4.385971e-01	0.358
Inositol phosphate metabolism	R-HSA-1483249	4.431631e-01	0.353
Co-inhibition by CTLA4	R-HSA-389513	4.441557e-01	0.352
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.450182e-01	0.352
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.450182e-01	0.352
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.450182e-01	0.352
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.450182e-01	0.352
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.450182e-01	0.352
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.450182e-01	0.352
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.450182e-01	0.352
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.450182e-01	0.352
Alanine metabolism	R-HSA-8964540	4.450182e-01	0.352
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.450182e-01	0.352
TNFR1-mediated ceramide production	R-HSA-5626978	4.450182e-01	0.352
NADE modulates death signalling	R-HSA-205025	4.450182e-01	0.352
Dopamine receptors	R-HSA-390651	4.450182e-01	0.352
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.491946e-01	0.348
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.491946e-01	0.348
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.518640e-01	0.345
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.537336e-01	0.343
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.548633e-01	0.342
RUNX3 regulates p14-ARF	R-HSA-8951936	4.653817e-01	0.332
Scavenging by Class F Receptors	R-HSA-3000484	4.653817e-01	0.332
OAS antiviral response	R-HSA-8983711	4.653817e-01	0.332
Leading Strand Synthesis	R-HSA-69109	4.653817e-01	0.332
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.653817e-01	0.332
Polymerase switching	R-HSA-69091	4.653817e-01	0.332
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.663682e-01	0.331
Activation of HOX genes during differentiation	R-HSA-5619507	4.663682e-01	0.331
Pyruvate metabolism	R-HSA-70268	4.678333e-01	0.330
Transcription of the HIV genome	R-HSA-167172	4.692119e-01	0.329
Lagging Strand Synthesis	R-HSA-69186	4.693336e-01	0.329
Intraflagellar transport	R-HSA-5620924	4.703081e-01	0.328
Activation of the pre-replicative complex	R-HSA-68962	4.704404e-01	0.327
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.704404e-01	0.327
RAS processing	R-HSA-9648002	4.705856e-01	0.327
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	4.705856e-01	0.327
Adipogenesis	R-HSA-9843745	4.745491e-01	0.324
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	4.793022e-01	0.319
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.793022e-01	0.319
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.836135e-01	0.316
Triglyceride metabolism	R-HSA-8979227	4.852719e-01	0.314
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.879651e-01	0.312
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.891001e-01	0.311
Diseases of Immune System	R-HSA-5260271	4.891001e-01	0.311
Diseases associated with the TLR signaling cascade	R-HSA-5602358	4.891001e-01	0.311
Molecules associated with elastic fibres	R-HSA-2129379	4.913753e-01	0.309
Mitochondrial calcium ion transport	R-HSA-8949215	4.939846e-01	0.306
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.968662e-01	0.304
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.968662e-01	0.304
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	4.968662e-01	0.304
PI5P Regulates TP53 Acetylation	R-HSA-6811555	4.968662e-01	0.304
Maturation of nucleoprotein	R-HSA-9683610	4.968662e-01	0.304
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	4.968662e-01	0.304
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	4.969058e-01	0.304
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.969058e-01	0.304
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.969058e-01	0.304
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.969058e-01	0.304
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.969058e-01	0.304
Muscarinic acetylcholine receptors	R-HSA-390648	4.969058e-01	0.304
Hydroxycarboxylic acid-binding receptors	R-HSA-3296197	4.969058e-01	0.304
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.969058e-01	0.304
Inositol transporters	R-HSA-429593	4.969058e-01	0.304
Nectin/Necl trans heterodimerization	R-HSA-420597	4.969058e-01	0.304
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.969058e-01	0.304
Co-inhibition by BTLA	R-HSA-9927353	4.969058e-01	0.304
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	4.969058e-01	0.304
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.969058e-01	0.304
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.969058e-01	0.304
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	4.969058e-01	0.304
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.969058e-01	0.304
Downstream TCR signaling	R-HSA-202424	5.060638e-01	0.296
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.073759e-01	0.295
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.073759e-01	0.295
DNA strand elongation	R-HSA-69190	5.119573e-01	0.291
Signaling by WNT in cancer	R-HSA-4791275	5.119573e-01	0.291
Stimuli-sensing channels	R-HSA-2672351	5.126883e-01	0.290
Notch-HLH transcription pathway	R-HSA-350054	5.180511e-01	0.286
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	5.200998e-01	0.284
Mitochondrial biogenesis	R-HSA-1592230	5.210902e-01	0.283
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.271394e-01	0.278
Removal of the Flap Intermediate	R-HSA-69166	5.271394e-01	0.278
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.271394e-01	0.278
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.271394e-01	0.278
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.271394e-01	0.278
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77310	5.271394e-01	0.278
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77350	5.271394e-01	0.278
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77348	5.271394e-01	0.278
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.271394e-01	0.278
Physiological factors	R-HSA-5578768	5.271394e-01	0.278
Acyl chain remodeling of CL	R-HSA-1482798	5.271394e-01	0.278
Zinc transporters	R-HSA-435354	5.271394e-01	0.278
HDL assembly	R-HSA-8963896	5.271394e-01	0.278
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.321490e-01	0.274
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.321490e-01	0.274
G-protein beta:gamma signalling	R-HSA-397795	5.321490e-01	0.274
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.321490e-01	0.274
Activation of ATR in response to replication stress	R-HSA-176187	5.321490e-01	0.274
Integration of energy metabolism	R-HSA-163685	5.360811e-01	0.271
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.430978e-01	0.265
Late SARS-CoV-2 Infection Events	R-HSA-9772573	5.434804e-01	0.265
Signalling to p38 via RIT and RIN	R-HSA-187706	5.439450e-01	0.264
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.439450e-01	0.264
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.439450e-01	0.264
PDE3B signalling	R-HSA-165160	5.439450e-01	0.264
PKB-mediated events	R-HSA-109703	5.439450e-01	0.264
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.439450e-01	0.264
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.439450e-01	0.264
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.439450e-01	0.264
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.439450e-01	0.264
Phosphorylation of Emi1	R-HSA-176417	5.439450e-01	0.264
Signaling by MAPK mutants	R-HSA-9652817	5.439450e-01	0.264
NGF-independant TRKA activation	R-HSA-187024	5.439450e-01	0.264
Cam-PDE 1 activation	R-HSA-111957	5.439450e-01	0.264
CLEC7A/inflammasome pathway	R-HSA-5660668	5.439450e-01	0.264
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.439450e-01	0.264
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.439450e-01	0.264
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.439450e-01	0.264
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.439450e-01	0.264
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.439450e-01	0.264
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.439450e-01	0.264
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.439450e-01	0.264
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.519178e-01	0.258
Resolution of D-Loop Structures	R-HSA-5693537	5.519178e-01	0.258
Miscellaneous transport and binding events	R-HSA-5223345	5.519178e-01	0.258
RNA Polymerase II Transcription	R-HSA-73857	5.533342e-01	0.257
Erythropoietin activates RAS	R-HSA-9027284	5.561528e-01	0.255
Adenylate cyclase inhibitory pathway	R-HSA-170670	5.561528e-01	0.255
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.561528e-01	0.255
Telomere C-strand synthesis initiation	R-HSA-174430	5.561528e-01	0.255
Formation of the anterior neural plate	R-HSA-9823739	5.561528e-01	0.255
Signaling by Activin	R-HSA-1502540	5.561528e-01	0.255
TRAF6 mediated NF-kB activation	R-HSA-933542	5.642455e-01	0.249
Plasma lipoprotein assembly	R-HSA-8963898	5.642455e-01	0.249
Interleukin-6 family signaling	R-HSA-6783589	5.642455e-01	0.249
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.712351e-01	0.243
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.738200e-01	0.241
Cyclin D associated events in G1	R-HSA-69231	5.775511e-01	0.238
G1 Phase	R-HSA-69236	5.775511e-01	0.238
Amine ligand-binding receptors	R-HSA-375280	5.775511e-01	0.238
Class I peroxisomal membrane protein import	R-HSA-9603798	5.838772e-01	0.234
Induction of Cell-Cell Fusion	R-HSA-9733458	5.838772e-01	0.234
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.838772e-01	0.234
Activation of SMO	R-HSA-5635838	5.838772e-01	0.234
Attachment and Entry	R-HSA-9678110	5.838772e-01	0.234
Fructose catabolism	R-HSA-70350	5.838772e-01	0.234
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	5.838772e-01	0.234
RSV-host interactions	R-HSA-9833110	5.853853e-01	0.233
Laminin interactions	R-HSA-3000157	5.863022e-01	0.232
Tight junction interactions	R-HSA-420029	5.863022e-01	0.232
Glycogen breakdown (glycogenolysis)	R-HSA-70221	5.863022e-01	0.232
Interleukin-7 signaling	R-HSA-1266695	5.863022e-01	0.232
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.865886e-01	0.232
Erythropoietin activates STAT5	R-HSA-9027283	5.865886e-01	0.232
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.865886e-01	0.232
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.865886e-01	0.232
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.865886e-01	0.232
G2/M DNA replication checkpoint	R-HSA-69478	5.865886e-01	0.232
VLDL assembly	R-HSA-8866423	5.865886e-01	0.232
Leukotriene receptors	R-HSA-391906	5.865886e-01	0.232
HDL clearance	R-HSA-8964011	5.865886e-01	0.232
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.865886e-01	0.232
PERK regulates gene expression	R-HSA-381042	5.900766e-01	0.229
C-type lectin receptors (CLRs)	R-HSA-5621481	5.910923e-01	0.228
Translation of Structural Proteins	R-HSA-9694635	5.938893e-01	0.226
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.942505e-01	0.226
Detoxification of Reactive Oxygen Species	R-HSA-3299685	5.985085e-01	0.223
Hemostasis	R-HSA-109582	6.067671e-01	0.217
Integrin cell surface interactions	R-HSA-216083	6.068627e-01	0.217
ABC transporter disorders	R-HSA-5619084	6.068627e-01	0.217
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	6.076303e-01	0.216
Myogenesis	R-HSA-525793	6.076303e-01	0.216
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.076303e-01	0.216
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	6.076303e-01	0.216
G beta:gamma signalling through CDC42	R-HSA-8964616	6.103000e-01	0.214
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.103000e-01	0.214
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.103000e-01	0.214
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.103000e-01	0.214
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77346	6.103000e-01	0.214
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.196207e-01	0.208
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.252471e-01	0.204
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.252471e-01	0.204
TRIF-mediated programmed cell death	R-HSA-2562578	6.252471e-01	0.204
Disinhibition of SNARE formation	R-HSA-114516	6.252471e-01	0.204
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.252471e-01	0.204
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.252471e-01	0.204
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.252471e-01	0.204
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.252471e-01	0.204
LDL remodeling	R-HSA-8964041	6.252471e-01	0.204
Activation of TRKA receptors	R-HSA-187015	6.252471e-01	0.204
Signaling by Nuclear Receptors	R-HSA-9006931	6.254804e-01	0.204
Regulation of insulin secretion	R-HSA-422356	6.261415e-01	0.203
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	6.265132e-01	0.203
RNA Polymerase I Transcription Termination	R-HSA-73863	6.282122e-01	0.202
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.282122e-01	0.202
Insulin processing	R-HSA-264876	6.282122e-01	0.202
PI3K events in ERBB2 signaling	R-HSA-1963642	6.354222e-01	0.197
Specification of primordial germ cells	R-HSA-9827857	6.354222e-01	0.197
Beta-catenin independent WNT signaling	R-HSA-3858494	6.388566e-01	0.195
GPER1 signaling	R-HSA-9634597	6.420507e-01	0.192
NGF-stimulated transcription	R-HSA-9031628	6.420507e-01	0.192
Metal ion SLC transporters	R-HSA-425410	6.420507e-01	0.192
Elastic fibre formation	R-HSA-1566948	6.435607e-01	0.191
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.435607e-01	0.191
MET promotes cell motility	R-HSA-8875878	6.435607e-01	0.191
Phase 0 - rapid depolarisation	R-HSA-5576892	6.480364e-01	0.188
Inflammasomes	R-HSA-622312	6.480364e-01	0.188
Pyroptosis	R-HSA-5620971	6.480364e-01	0.188
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.592559e-01	0.181
GAB1 signalosome	R-HSA-180292	6.592559e-01	0.181
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.592559e-01	0.181
Nephron development	R-HSA-9831926	6.592559e-01	0.181
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	6.602927e-01	0.180
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.602927e-01	0.180
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	6.602927e-01	0.180
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	6.602927e-01	0.180
Interleukin-9 signaling	R-HSA-8985947	6.602927e-01	0.180
Sodium/Proton exchangers	R-HSA-425986	6.602927e-01	0.180
Interleukin-23 signaling	R-HSA-9020933	6.602927e-01	0.180
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.603309e-01	0.180
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.688061e-01	0.175
PI Metabolism	R-HSA-1483255	6.696812e-01	0.174
tRNA processing	R-HSA-72306	6.727762e-01	0.172
FCGR3A-mediated phagocytosis	R-HSA-9664422	6.754435e-01	0.170
Parasite infection	R-HSA-9664407	6.754435e-01	0.170
Leishmania phagocytosis	R-HSA-9664417	6.754435e-01	0.170
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.765580e-01	0.170
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.765580e-01	0.170
Other interleukin signaling	R-HSA-449836	6.818225e-01	0.166
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	6.826935e-01	0.166
GABA synthesis, release, reuptake and degradation	R-HSA-888590	6.853913e-01	0.164
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	6.853913e-01	0.164
Neuronal System	R-HSA-112316	6.890051e-01	0.162
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.911147e-01	0.160
WNT mediated activation of DVL	R-HSA-201688	6.920628e-01	0.160
Inactivation of CDC42 and RAC1	R-HSA-428543	6.920628e-01	0.160
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.920628e-01	0.160
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.920628e-01	0.160
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.920628e-01	0.160
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.920628e-01	0.160
Interleukin-21 signaling	R-HSA-9020958	6.920628e-01	0.160
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.920628e-01	0.160
Unwinding of DNA	R-HSA-176974	6.920628e-01	0.160
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.920628e-01	0.160
Regulated proteolysis of p75NTR	R-HSA-193692	6.920628e-01	0.160
Interleukin-1 processing	R-HSA-448706	6.920628e-01	0.160
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	6.920628e-01	0.160
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.920628e-01	0.160
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	7.029233e-01	0.153
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.031504e-01	0.153
Formation of ATP by chemiosmotic coupling	R-HSA-163210	7.031504e-01	0.153
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.031504e-01	0.153
Protein hydroxylation	R-HSA-9629569	7.031504e-01	0.153
Signaling by NODAL	R-HSA-1181150	7.031504e-01	0.153
Formation of definitive endoderm	R-HSA-9823730	7.031504e-01	0.153
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.045267e-01	0.152
Iron uptake and transport	R-HSA-917937	7.045267e-01	0.152
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.073681e-01	0.150
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.208634e-01	0.142
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	7.208634e-01	0.142
MAPK3 (ERK1) activation	R-HSA-110056	7.208634e-01	0.142
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	7.208634e-01	0.142
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.208634e-01	0.142
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.208634e-01	0.142
Arachidonate production from DAG	R-HSA-426048	7.208634e-01	0.142
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.208634e-01	0.142
CASP4 inflammasome assembly	R-HSA-9948001	7.208634e-01	0.142
Receptor Mediated Mitophagy	R-HSA-8934903	7.208634e-01	0.142
Interleukin-27 signaling	R-HSA-9020956	7.208634e-01	0.142
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.232739e-01	0.141
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.232739e-01	0.141
Zygotic genome activation (ZGA)	R-HSA-9819196	7.232739e-01	0.141
FGFR1 mutant receptor activation	R-HSA-1839124	7.357284e-01	0.133
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.357284e-01	0.133
G alpha (z) signalling events	R-HSA-418597	7.390358e-01	0.131
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.422316e-01	0.129
Attachment and Entry	R-HSA-9694614	7.422316e-01	0.129
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	7.422316e-01	0.129
Ribavirin ADME	R-HSA-9755088	7.422316e-01	0.129
Extracellular matrix organization	R-HSA-1474244	7.466187e-01	0.127
Ionotropic activity of kainate receptors	R-HSA-451306	7.469719e-01	0.127
vRNA Synthesis	R-HSA-192814	7.469719e-01	0.127
vRNP Assembly	R-HSA-192905	7.469719e-01	0.127
Chylomicron assembly	R-HSA-8963888	7.469719e-01	0.127
Bicarbonate transporters	R-HSA-425381	7.469719e-01	0.127
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.469719e-01	0.127
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.469719e-01	0.127
LGI-ADAM interactions	R-HSA-5682910	7.469719e-01	0.127
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.469719e-01	0.127
Transport of RCbl within the body	R-HSA-9758890	7.469719e-01	0.127
Dissolution of Fibrin Clot	R-HSA-75205	7.469719e-01	0.127
Transport to the Golgi and subsequent modification	R-HSA-948021	7.485810e-01	0.126
Proteasome assembly	R-HSA-9907900	7.494798e-01	0.125
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.510236e-01	0.124
Glucagon signaling in metabolic regulation	R-HSA-163359	7.510236e-01	0.124
Heme degradation	R-HSA-189483	7.510236e-01	0.124
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.600656e-01	0.119
Fructose metabolism	R-HSA-5652084	7.600656e-01	0.119
Signaling by KIT in disease	R-HSA-9669938	7.600656e-01	0.119
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.624386e-01	0.118
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.624386e-01	0.118
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.624386e-01	0.118
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	7.628913e-01	0.118
NPAS4 regulates expression of target genes	R-HSA-9768919	7.655995e-01	0.116
eNOS activation	R-HSA-203615	7.655995e-01	0.116
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.685118e-01	0.114
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.706397e-01	0.113
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.706397e-01	0.113
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.706397e-01	0.113
FMO oxidises nucleophiles	R-HSA-217271	7.706397e-01	0.113
Signaling by TGFBR3	R-HSA-9839373	7.748695e-01	0.111
Regulation of PTEN mRNA translation	R-HSA-8943723	7.768202e-01	0.110
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.768202e-01	0.110
Interleukin-20 family signaling	R-HSA-8854691	7.768202e-01	0.110
ABC transporters in lipid homeostasis	R-HSA-1369062	7.768202e-01	0.110
Peroxisomal protein import	R-HSA-9033241	7.850610e-01	0.105
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	7.874274e-01	0.104
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	7.920950e-01	0.101
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77305	7.920950e-01	0.101
Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77285	7.920950e-01	0.101
GRB2 events in EGFR signaling	R-HSA-179812	7.920950e-01	0.101
SHC-related events triggered by IGF1R	R-HSA-2428933	7.920950e-01	0.101
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.920950e-01	0.101
Interleukin-35 Signalling	R-HSA-8984722	7.920950e-01	0.101
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.920950e-01	0.101
Signaling by LTK	R-HSA-9842663	7.920950e-01	0.101
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.920950e-01	0.101
Maple Syrup Urine Disease	R-HSA-9865114	7.920950e-01	0.101
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.920950e-01	0.101
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.920950e-01	0.101
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.925412e-01	0.101
Mitochondrial RNA degradation	R-HSA-9836573	7.925412e-01	0.101
RUNX2 regulates bone development	R-HSA-8941326	7.926626e-01	0.101
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.955266e-01	0.099
Generic Transcription Pathway	R-HSA-212436	7.968550e-01	0.099
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.985002e-01	0.098
Diseases of carbohydrate metabolism	R-HSA-5663084	8.046094e-01	0.094
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.072753e-01	0.093
Adenylate cyclase activating pathway	R-HSA-170660	8.115445e-01	0.091
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.115445e-01	0.091
Microbial factors inhibit CASP4 activity	R-HSA-9956593	8.115445e-01	0.091
Processing of SMDT1	R-HSA-8949664	8.115445e-01	0.091
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.115445e-01	0.091
Platelet Adhesion to exposed collagen	R-HSA-75892	8.115445e-01	0.091
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.170697e-01	0.088
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.177183e-01	0.087
Azathioprine ADME	R-HSA-9748787	8.195098e-01	0.086
MET activates PTK2 signaling	R-HSA-8874081	8.210695e-01	0.086
TRP channels	R-HSA-3295583	8.210695e-01	0.086
Urea cycle	R-HSA-70635	8.210695e-01	0.086
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.217360e-01	0.085
Leishmania infection	R-HSA-9658195	8.243888e-01	0.084
Parasitic Infection Pathways	R-HSA-9824443	8.243888e-01	0.084
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.283297e-01	0.082
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	8.283297e-01	0.082
Retrograde neurotrophin signalling	R-HSA-177504	8.291755e-01	0.081
CRMPs in Sema3A signaling	R-HSA-399956	8.291755e-01	0.081
Hydrolysis of LPC	R-HSA-1483115	8.291755e-01	0.081
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.291755e-01	0.081
Non-canonical inflammasome activation	R-HSA-9686114	8.291755e-01	0.081
Signal regulatory protein family interactions	R-HSA-391160	8.291755e-01	0.081
Insulin receptor signalling cascade	R-HSA-74751	8.334223e-01	0.079
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	8.339707e-01	0.079
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	8.339707e-01	0.079
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.339707e-01	0.079
Maturation of hRSV A proteins	R-HSA-9828806	8.339707e-01	0.079
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.389419e-01	0.076
HIV Transcription Elongation	R-HSA-167169	8.389900e-01	0.076
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	8.389900e-01	0.076
Nuclear signaling by ERBB4	R-HSA-1251985	8.389900e-01	0.076
FOXO-mediated transcription	R-HSA-9614085	8.438354e-01	0.074
SHC1 events in EGFR signaling	R-HSA-180336	8.451579e-01	0.073
Protein lipoylation	R-HSA-9857492	8.451579e-01	0.073
DNA Damage Reversal	R-HSA-73942	8.451579e-01	0.073
Beta oxidation of butanoyl-CoA to acetyl-CoA	R-HSA-77352	8.451579e-01	0.073
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.451579e-01	0.073
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.451579e-01	0.073
Other semaphorin interactions	R-HSA-416700	8.451579e-01	0.073
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.460253e-01	0.073
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.460253e-01	0.073
Disease	R-HSA-1643685	8.469726e-01	0.072
Amino acids regulate mTORC1	R-HSA-9639288	8.479812e-01	0.072
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.490732e-01	0.071
Neurotransmitter release cycle	R-HSA-112310	8.515559e-01	0.070
Signaling by Erythropoietin	R-HSA-9006335	8.572785e-01	0.067
mRNA Capping	R-HSA-72086	8.572785e-01	0.067
Regulation of gene expression in beta cells	R-HSA-210745	8.572785e-01	0.067
Glucagon-type ligand receptors	R-HSA-420092	8.572785e-01	0.067
Signaling by FGFR1 in disease	R-HSA-5655302	8.586021e-01	0.066
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	R-HSA-2142816	8.596459e-01	0.066
Killing mechanisms	R-HSA-9664420	8.596459e-01	0.066
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.596459e-01	0.066
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	8.596459e-01	0.066
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.596459e-01	0.066
Differentiation of T cells	R-HSA-9945266	8.596459e-01	0.066
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.596459e-01	0.066
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.596459e-01	0.066
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.596459e-01	0.066
Atorvastatin ADME	R-HSA-9754706	8.596459e-01	0.066
Virus Assembly and Release	R-HSA-168268	8.596459e-01	0.066
PPARA activates gene expression	R-HSA-1989781	8.650463e-01	0.063
Cytosolic tRNA aminoacylation	R-HSA-379716	8.675993e-01	0.062
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.677749e-01	0.062
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	8.727791e-01	0.059
Glycine degradation	R-HSA-6783984	8.727791e-01	0.059
Fibronectin matrix formation	R-HSA-1566977	8.727791e-01	0.059
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.727791e-01	0.059
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	R-HSA-77288	8.727791e-01	0.059
TRAF3-dependent IRF activation pathway	R-HSA-918233	8.727791e-01	0.059
tRNA modification in the mitochondrion	R-HSA-6787450	8.727791e-01	0.059
Galactose catabolism	R-HSA-70370	8.727791e-01	0.059
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.747075e-01	0.058
Cargo concentration in the ER	R-HSA-5694530	8.775575e-01	0.057
Aspartate and asparagine metabolism	R-HSA-8963693	8.775575e-01	0.057
Downstream signal transduction	R-HSA-186763	8.775575e-01	0.057
Cytoprotection by HMOX1	R-HSA-9707564	8.806117e-01	0.055
Mitochondrial protein degradation	R-HSA-9837999	8.830133e-01	0.054
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.846841e-01	0.053
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.846841e-01	0.053
Regulation of NPAS4 gene expression	R-HSA-9768759	8.846841e-01	0.053
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.846841e-01	0.053
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.846841e-01	0.053
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.866679e-01	0.052
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	8.920094e-01	0.050
Regulation of beta-cell development	R-HSA-186712	8.936295e-01	0.049
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.936295e-01	0.049
Cardiogenesis	R-HSA-9733709	8.951463e-01	0.048
G beta:gamma signalling through PLC beta	R-HSA-418217	8.954757e-01	0.048
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	R-HSA-2142670	8.954757e-01	0.048
Presynaptic function of Kainate receptors	R-HSA-500657	8.954757e-01	0.048
RNA Polymerase III Transcription Termination	R-HSA-73980	8.954757e-01	0.048
Vitamin D (calciferol) metabolism	R-HSA-196791	8.954757e-01	0.048
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.954757e-01	0.048
Ca2+ pathway	R-HSA-4086398	8.979113e-01	0.047
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.987215e-01	0.046
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.987215e-01	0.046
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.987215e-01	0.046
tRNA Aminoacylation	R-HSA-379724	8.999402e-01	0.046
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	9.052579e-01	0.043
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.052579e-01	0.043
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.052579e-01	0.043
Methionine salvage pathway	R-HSA-1237112	9.052579e-01	0.043
IRS-related events triggered by IGF1R	R-HSA-2428928	9.059182e-01	0.043
Aquaporin-mediated transport	R-HSA-445717	9.059182e-01	0.043
Formation of paraxial mesoderm	R-HSA-9793380	9.059182e-01	0.043
Protein localization	R-HSA-9609507	9.083152e-01	0.042
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.103590e-01	0.041
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.103590e-01	0.041
Signal amplification	R-HSA-392518	9.103590e-01	0.041
Disorders of transmembrane transporters	R-HSA-5619115	9.111998e-01	0.040
NCAM signaling for neurite out-growth	R-HSA-375165	9.115773e-01	0.040
Signaling by PDGF	R-HSA-186797	9.115773e-01	0.040
VxPx cargo-targeting to cilium	R-HSA-5620916	9.141252e-01	0.039
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.141252e-01	0.039
Acyl chain remodelling of PI	R-HSA-1482922	9.141252e-01	0.039
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.141252e-01	0.039
Eicosanoid ligand-binding receptors	R-HSA-391903	9.141252e-01	0.039
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.179930e-01	0.037
IGF1R signaling cascade	R-HSA-2428924	9.219934e-01	0.035
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.221631e-01	0.035
G-protein activation	R-HSA-202040	9.221631e-01	0.035
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.221631e-01	0.035
Acyl chain remodelling of PG	R-HSA-1482925	9.221631e-01	0.035
Basigin interactions	R-HSA-210991	9.221631e-01	0.035
PI3K Cascade	R-HSA-109704	9.230924e-01	0.035
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.234834e-01	0.035
RNA Polymerase III Transcription	R-HSA-74158	9.234834e-01	0.035
Glycosphingolipid transport	R-HSA-9845576	9.234834e-01	0.035
GPVI-mediated activation cascade	R-HSA-114604	9.234834e-01	0.035
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.267768e-01	0.033
The phototransduction cascade	R-HSA-2514856	9.282822e-01	0.032
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.294490e-01	0.032
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	9.294490e-01	0.032
Molybdenum cofactor biosynthesis	R-HSA-947581	9.294490e-01	0.032
Serine metabolism	R-HSA-977347	9.294490e-01	0.032
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.294490e-01	0.032
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.303104e-01	0.031
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.303104e-01	0.031
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.303104e-01	0.031
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.360533e-01	0.029
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.360533e-01	0.029
LDL clearance	R-HSA-8964038	9.360533e-01	0.029
Ethanol oxidation	R-HSA-71384	9.360533e-01	0.029
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.360533e-01	0.029
Neurotoxicity of clostridium toxins	R-HSA-168799	9.360533e-01	0.029
Neddylation	R-HSA-8951664	9.369481e-01	0.028
Nucleotide biosynthesis	R-HSA-8956320	9.377086e-01	0.028
Innate Immune System	R-HSA-168249	9.404075e-01	0.027
Free fatty acids regulate insulin secretion	R-HSA-400451	9.420397e-01	0.026
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.420397e-01	0.026
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.420397e-01	0.026
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.420397e-01	0.026
Interleukin receptor SHC signaling	R-HSA-912526	9.420397e-01	0.026
Formation of the ureteric bud	R-HSA-9830674	9.420397e-01	0.026
Mitochondrial mRNA modification	R-HSA-9937008	9.420397e-01	0.026
Carnitine shuttle	R-HSA-200425	9.420397e-01	0.026
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.444834e-01	0.025
Interleukin-2 family signaling	R-HSA-451927	9.444834e-01	0.025
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.474661e-01	0.023
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.474661e-01	0.023
Complex III assembly	R-HSA-9865881	9.474661e-01	0.023
SLC transporter disorders	R-HSA-5619102	9.496781e-01	0.022
ECM proteoglycans	R-HSA-3000178	9.503121e-01	0.022
G alpha (q) signalling events	R-HSA-416476	9.512008e-01	0.022
Acyl chain remodelling of PS	R-HSA-1482801	9.523847e-01	0.021
Hyaluronan degradation	R-HSA-2160916	9.523847e-01	0.021
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.523847e-01	0.021
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.523847e-01	0.021
HIV Transcription Initiation	R-HSA-167161	9.528020e-01	0.021
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.528020e-01	0.021
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.528020e-01	0.021
Intra-Golgi traffic	R-HSA-6811438	9.528020e-01	0.021
Scavenging by Class A Receptors	R-HSA-3000480	9.528020e-01	0.021
Degradation of the extracellular matrix	R-HSA-1474228	9.528696e-01	0.021
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.531695e-01	0.021
IRS-mediated signalling	R-HSA-112399	9.532161e-01	0.021
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.553960e-01	0.020
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.564855e-01	0.019
Activation of GABAB receptors	R-HSA-991365	9.565007e-01	0.019
GABA B receptor activation	R-HSA-977444	9.565007e-01	0.019
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.568430e-01	0.019
Attachment of bacteria to epithelial cells	R-HSA-9638630	9.568430e-01	0.019
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.568430e-01	0.019
Sphingolipid catabolism	R-HSA-9845614	9.568430e-01	0.019
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.568430e-01	0.019
Signaling by FGFR in disease	R-HSA-1226099	9.592669e-01	0.018
RNA Polymerase II Promoter Escape	R-HSA-73776	9.599209e-01	0.018
Triglyceride biosynthesis	R-HSA-75109	9.608842e-01	0.017
Signaling by BMP	R-HSA-201451	9.608842e-01	0.017
Synthesis of PE	R-HSA-1483213	9.608842e-01	0.017
Post-translational protein modification	R-HSA-597592	9.625024e-01	0.017
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	9.645471e-01	0.016
Formation of the Early Elongation Complex	R-HSA-113418	9.645471e-01	0.016
Pyrimidine salvage	R-HSA-73614	9.645471e-01	0.016
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.660033e-01	0.015
mitochondrial fatty acid beta-oxidation of saturated fatty acids	R-HSA-77286	9.660033e-01	0.015
Degradation of cysteine and homocysteine	R-HSA-1614558	9.660033e-01	0.015
Somitogenesis	R-HSA-9824272	9.660033e-01	0.015
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.667073e-01	0.015
Mitochondrial protein import	R-HSA-1268020	9.675381e-01	0.014
Cholesterol biosynthesis	R-HSA-191273	9.688918e-01	0.014
DAP12 signaling	R-HSA-2424491	9.708767e-01	0.013
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.708767e-01	0.013
Neurotransmitter clearance	R-HSA-112311	9.708767e-01	0.013
Signaling by Insulin receptor	R-HSA-74752	9.712574e-01	0.013
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.730393e-01	0.012
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.736044e-01	0.012
Collagen formation	R-HSA-1474290	9.747181e-01	0.011
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.756126e-01	0.011
FCERI mediated NF-kB activation	R-HSA-2871837	9.772229e-01	0.010
Kidney development	R-HSA-9830369	9.776456e-01	0.010
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.783177e-01	0.010
Interferon gamma signaling	R-HSA-877300	9.789524e-01	0.009
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.803488e-01	0.009
Acyl chain remodelling of PC	R-HSA-1482788	9.803488e-01	0.009
Glutamate and glutamine metabolism	R-HSA-8964539	9.803488e-01	0.009
Formation of the cornified envelope	R-HSA-6809371	9.815691e-01	0.008
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.821898e-01	0.008
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.821898e-01	0.008
Hyaluronan metabolism	R-HSA-2142845	9.821898e-01	0.008
RA biosynthesis pathway	R-HSA-5365859	9.821898e-01	0.008
Gastrulation	R-HSA-9758941	9.826426e-01	0.008
Metabolism of porphyrins	R-HSA-189445	9.834947e-01	0.007
Metabolism of cofactors	R-HSA-8978934	9.834947e-01	0.007
Acyl chain remodelling of PE	R-HSA-1482839	9.838584e-01	0.007
Transferrin endocytosis and recycling	R-HSA-917977	9.838584e-01	0.007
Paracetamol ADME	R-HSA-9753281	9.852823e-01	0.006
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.852956e-01	0.006
Lysosome Vesicle Biogenesis	R-HSA-432720	9.853708e-01	0.006
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.853708e-01	0.006
FGFR2 mutant receptor activation	R-HSA-1839126	9.853708e-01	0.006
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.862639e-01	0.006
Voltage gated Potassium channels	R-HSA-1296072	9.867415e-01	0.006
TRAF6 mediated IRF7 activation	R-HSA-933541	9.867415e-01	0.006
Metabolism of folate and pterines	R-HSA-196757	9.867415e-01	0.006
Collagen chain trimerization	R-HSA-8948216	9.867415e-01	0.006
Synthesis of PA	R-HSA-1483166	9.875824e-01	0.005
tRNA processing in the mitochondrion	R-HSA-6785470	9.879839e-01	0.005
Biofilm formation	R-HSA-9931953	9.879839e-01	0.005
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.885971e-01	0.005
Pentose phosphate pathway	R-HSA-71336	9.891099e-01	0.005
rRNA processing in the mitochondrion	R-HSA-8868766	9.901305e-01	0.004
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.901305e-01	0.004
GABA receptor activation	R-HSA-977443	9.903896e-01	0.004
Metabolism of polyamines	R-HSA-351202	9.903896e-01	0.004
Maturation of spike protein	R-HSA-9694548	9.910555e-01	0.004
Collagen degradation	R-HSA-1442490	9.911795e-01	0.004
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.918938e-01	0.004
CD22 mediated BCR regulation	R-HSA-5690714	9.931873e-01	0.003
Pyrimidine catabolism	R-HSA-73621	9.933423e-01	0.003
FCERI mediated MAPK activation	R-HSA-2871796	9.933855e-01	0.003
Metabolism of proteins	R-HSA-392499	9.937747e-01	0.003
DAP12 interactions	R-HSA-2172127	9.939664e-01	0.003
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.939664e-01	0.003
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.939664e-01	0.003
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.939773e-01	0.003
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.942694e-01	0.002
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.951824e-01	0.002
Sulfur amino acid metabolism	R-HSA-1614635	9.952716e-01	0.002
G alpha (s) signalling events	R-HSA-418555	9.953699e-01	0.002
Synthesis of PC	R-HSA-1483191	9.955093e-01	0.002
Leishmania parasite growth and survival	R-HSA-9664433	9.958934e-01	0.002
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.958934e-01	0.002
Plasma lipoprotein remodeling	R-HSA-8963899	9.959304e-01	0.002
Peptide hormone metabolism	R-HSA-2980736	9.959516e-01	0.002
COPII-mediated vesicle transport	R-HSA-204005	9.959523e-01	0.002
Class B/2 (Secretin family receptors)	R-HSA-373080	9.965678e-01	0.001
Signaling by FGFR2 in disease	R-HSA-5655253	9.966578e-01	0.001
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.966578e-01	0.001
Complex IV assembly	R-HSA-9864848	9.969713e-01	0.001
Branched-chain amino acid catabolism	R-HSA-70895	9.969713e-01	0.001
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.978881e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.979933e-01	0.001
Asparagine N-linked glycosylation	R-HSA-446203	9.984816e-01	0.001
Synthesis of bile acids and bile salts	R-HSA-192105	9.985969e-01	0.001
GPCR downstream signalling	R-HSA-388396	9.986098e-01	0.001
Amino acid transport across the plasma membrane	R-HSA-352230	9.986227e-01	0.001
Signaling by Retinoic Acid	R-HSA-5362517	9.987520e-01	0.001
Endogenous sterols	R-HSA-211976	9.988691e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.988691e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.988981e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.990714e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.991585e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.993739e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.993739e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.994814e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.995342e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.995342e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.995374e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.995649e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.995834e-01	0.000
Aspirin ADME	R-HSA-9749641	9.996535e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.997122e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.997122e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.997155e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.997545e-01	0.000
Nuclear Receptor transcription pathway	R-HSA-383280	9.997884e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.998083e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.998083e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.998120e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.998733e-01	0.000
Respiratory electron transport	R-HSA-611105	9.998880e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999047e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999087e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999279e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999501e-01	0.000
Keratinization	R-HSA-6805567	9.999523e-01	0.000
FCGR activation	R-HSA-2029481	9.999605e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999685e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999734e-01	0.000
Potassium Channels	R-HSA-1296071	9.999734e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999781e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999800e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999835e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999867e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999871e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999891e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999895e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999901e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999933e-01	0.000
Drug ADME	R-HSA-9748784	9.999953e-01	0.000
Transport of small molecules	R-HSA-382551	9.999957e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999974e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999986e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999989e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999995e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999997e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999998e-01	0.000
Complement cascade	R-HSA-166658	9.999999e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000