P90RSK
Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
Motif clusters with count ≥ 10 are shown
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| substrate_uniprot | site | source | substrate_genes | site_seq |
|---|---|---|---|---|
| A4FU28 | S140 | Sugiyama | CTAGE9 | AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH |
| O00170 | S43 | Sugiyama | AIP XAP2 | GELPDFQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELI |
| O00418 | S366 | SIGNOR|ELM|iPTMNet|EPSD|PSP | EEF2K | AKtILRGtEEKCGsPQVRTLsGSRPPLLRPLsENSGDENMS |
| O00562 | S315 | Sugiyama | PITPNM1 DRES9 NIR2 PITPNM | PGPDAsPDAsFGKQWSSSSRssYsSQHGGAVsPQSLsEWRM |
| O00562 | S331 | Sugiyama | PITPNM1 DRES9 NIR2 PITPNM | SSSRssYsSQHGGAVsPQSLsEWRMQNIARDSENSSEEEFF |
| O14579 | S99 | Sugiyama | COPE | PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF |
| O14617 | S658 | Sugiyama | AP3D1 PRO0039 | DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN |
| O14727 | S268 | EPSD|PSP | APAF1 KIAA0413 | SWVLKAFDSQCQILLTTRDKsVTDSVMGPKYVVPVESSLGK |
| O14727 | S357 | EPSD|PSP | APAF1 KIAA0413 | RWEYYLKQLQNKQFKRIRKSsSYDYEALDEAMSISVEMLRE |
| O14745 | T156 | EPSD|PSP | NHERF1 NHERF SLC9A3R1 | EPREADKSHPEQRELRPRLCtMKKGPsGYGFNLHSDKSKPG |
| O14757 | S280 | EPSD|PSP | CHEK1 CHK1 | KKDRWYNKPLKKGAKRPRVtsGGVsEsPsGFsKHIQsNLDF |
| O14910 | S157 | Sugiyama | LIN7A MALS1 VELI1 | IIPGGVAERHGGLKRGDQLLsVNGVSVEGEHHEKAVELLKA |
| O14974 | S910 | Sugiyama | PPP1R12A MBS MYPT1 | yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST |
| O14974 | S995 | Sugiyama | PPP1R12A MBS MYPT1 | ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK |
| O14980 | S1055 | Sugiyama | XPO1 CRM1 | LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____ |
| O15067 | S215 | Sugiyama | PFAS KIAA0361 | LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF |
| O15085 | S635 | Sugiyama | ARHGEF11 KIAA0380 | LKGREEMKRSRKAENVPRsRsDVDMDAAAEATRLHQsAsss |
| O15234 | S10 | Sugiyama | CASC3 MLN51 | ___________MADRRRQRAsQDtEDEESGASGsDsGGsPL |
| O15460 | S531 | Sugiyama | P4HA2 UNQ290/PRO330 | KWVSNKWFHERGQEFLRPCGstEVD________________ |
| O43175 | S12 | Sugiyama | PHGDH PGDH3 | _________MAFANLRKVLIsDsLDPCCRKILQDGGLQVVE |
| O43847 | S94 | Sugiyama | NRDC NRD1 | ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR |
| O43847 | T59 | Sugiyama | NRDC NRD1 | SAAARPFPILAMPGRNKAKstCsCPDLQPNGQDLGENSRVA |
| O60220 | S94 | Sugiyama | TIMM8A DDP DDP1 TIM8A | SQFILNRLEQTQKSKPVFSEsLsD_________________ |
| O60343 | S318 | PSP | TBC1D4 AS160 KIAA0603 | ERILEDsGFDEQQEFRsRCssVTGVQRRVHEGSQKSQPRRR |
| O60343 | S341 | PSP | TBC1D4 AS160 KIAA0603 | GVQRRVHEGSQKSQPRRRHAsAPsHVQPSDSEKNRTMLFQV |
| O60343 | S570 | PSP | TBC1D4 AS160 KIAA0603 | ssGRFKLDILKNKAKRsLtssLENIFSRGANRMRGRLGsVD |
| O60343 | S588 | PSP | TBC1D4 AS160 KIAA0603 | tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD |
| O60343 | S666 | PSP | TBC1D4 AS160 KIAA0603 | PPsstKRKLNLQDGRAQGVRsPLLRQSssEQCSNLSSVRRM |
| O60343 | S751 | PSP | TBC1D4 AS160 KIAA0603 | EIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRIS |
| O60343 | S754 | Sugiyama | TBC1D4 AS160 KIAA0603 | QDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRISWRQ |
| O60343 | T568 | PSP | TBC1D4 AS160 KIAA0603 | AtssGRFKLDILKNKAKRsLtssLENIFSRGANRMRGRLGs |
| O60343 | T642 | PSP | TBC1D4 AS160 KIAA0603 | AWQTFPEEDSDSPQFRRRAHtFsHPPsstKRKLNLQDGRAQ |
| O60343 | T749 | Sugiyama | TBC1D4 AS160 KIAA0603 | ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR |
| O60814 | S37 | Sugiyama | H2BC12 H2BFT HIRIP1 HIST1H2BK | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| O60841 | S107 | Sugiyama | EIF5B IF2 KIAA0741 | NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA |
| O60841 | S182 | Sugiyama | EIF5B IF2 KIAA0741 | DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK |
| O60841 | S183 | Sugiyama | EIF5B IF2 KIAA0741 | GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN |
| O75030 | S409 | SIGNOR | MITF BHLHE32 | LLRIQELEMQARAHGLsLIPsTGLCsPDLVNRIIKQEPVLE |
| O75122 | S523 | Sugiyama | CLASP2 KIAA0627 | sREAsPSRLSVARSSRIPRPsVsQGCsREAsRESsRDTsPV |
| O75347 | S103 | Sugiyama | TBCA | ENEKDLEEAEEyKEARLVLDsVKLEA_______________ |
| O75369 | S1442 | Sugiyama | FLNB FLN1L FLN3 TABP TAP | SKVKIAGPGLGsGVRARVLQsFtVDSSKAGLAPLEVRVLGP |
| O75494 | S133 | Sugiyama | SRSF10 FUSIP1 FUSIP2 SFRS13A TASR | yDRYRRSRSRSYERRRsRsRsFDyNYRRsYsPRNSRPTGRP |
| O76003 | S117 | Sugiyama | GLRX3 PICOT TXNL2 HUSSY-22 | IDRLDGAHAPELTKKVQRHAssGsFLPSANEHLKEDLNLRL |
| O94761 | S27 | Sugiyama | RECQL4 RECQ4 | VRERLQAWERAFRRQRGRRPsQDDVEAAPEETRALYREYRT |
| O94888 | S280 | Sugiyama | UBXN7 KIAA0794 UBXD7 | EHGQLDGLsssPPKKCARsEsLIDAsEDsQLEAAIRASLQE |
| O94915 | S1957 | Sugiyama | FRYL AF4P12 KIAA0826 | ARsNsLRLsLIGDRRGDRRRsNtLDIMDGRINHsssLARtR |
| O95071 | S1227 | EPSD|PSP | UBR5 EDD EDD1 HYD KIAA0896 | CCTECARVCHKGHDCKLKRtsPTAYCDCWEKCKCKTLIAGQ |
| O95071 | S2483 | EPSD|PSP | UBR5 EDD EDD1 HYD KIAA0896 | DLGLVDssEKVQQENRKRHGssRsVVDMDLDDtDDGDDNAP |
| O95071 | T637 | EPSD|PSP | UBR5 EDD EDD1 HYD KIAA0896 | CsDAsSIASSASMPYKRRRstPAPKEEEKVNEEQWSLREVV |
| O95155 | S105 | Sugiyama | UBE4B HDNB1 KIAA0684 UFD2 | LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG |
| O95613 | S44 | Sugiyama | PCNT KIAA0402 PCNT2 | QRKTKGDSSHSEKKTAKRKGsAVDAsVQEEsPVTKEDsALC |
| O95714 | S2928 | Sugiyama | HERC2 | ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA |
| O95831 | S116 | Sugiyama | AIFM1 AIF PDCD8 | NERIsGLGLtPEQKQKKAALsAsEGEEVPQDKAPSHVPFLL |
| P00338 | S161 | Sugiyama | LDHA PIG19 | DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH |
| P00491 | S176 | Sugiyama | PNP NP | GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA |
| P01100 | S362 | SIGNOR|ELM|iPTMNet|EPSD|PSP | FOS G0S7 | VFTYPEADSFPSCAAAHRKGsSsNEPSSDSLSsPTLLAL__ |
| P01100 | S374 | SIGNOR | FOS G0S7 | CAAAHRKGsSsNEPSSDSLSsPTLLAL______________ |
| P03372 | S118 | ELM|iPTMNet | ESR1 ESR NR3A1 | PPLNsVsPsPLMLLHPPPQLsPFLQPHGQQVPYYLENEPSG |
| P03372 | S167 | SIGNOR|ELM|iPTMNet|EPSD|PSP | ESR1 ESR NR3A1 | PAFYRPNsDNRRQGGRERLAsTNDKGSMAMESAKETRYCAV |
| P04075 | S336 | Sugiyama | ALDOA ALDA | GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs |
| P04075 | S39 | Sugiyama | ALDOA ALDA | IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy |
| P04075 | S46 | Sugiyama | ALDOA ALDA | PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA |
| P04406 | S241 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV |
| P04406 | S312 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA |
| P04792 | S82 | Sugiyama | HSPB1 HSP27 HSP28 | AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN |
| P05386 | S101 | Sugiyama | RPLP1 RRP1 | APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______ |
| P05387 | S102 | Sugiyama | RPLP2 D11S2243E RPP2 | PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______ |
| P05387 | S29 | Sugiyama | RPLP2 D11S2243E RPP2 | LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK |
| P05783 | S93 | Sugiyama | KRT18 CYK18 PIG46 | GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR |
| P05787 | S330 | Sugiyama | KRT8 CYK8 | MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN |
| P05787 | S475 | Sugiyama | KRT8 CYK8 | TSSSRAVVVKKIETRDGKLVsEssDVLPK____________ |
| P06493 | S39 | Sugiyama | CDK1 CDC2 CDC28A CDKN1 P34CDC2 | yKGRHKTTGQVVAMKKIRLEsEEEGVPstAIREIsLLKELR |
| P06733 | S37 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY |
| P06733 | S40 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK |
| P06899 | S37 | Sugiyama | H2BC11 H2BFR HIST1H2BJ | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS |
| P07195 | S162 | Sugiyama | LDHB | DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH |
| P07195 | S303 | Sugiyama | LDHB | GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt |
| P07195 | S320 | Sugiyama | LDHB | GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______ |
| P07195 | S44 | Sugiyama | LDHB | ITVVGVGQVGMACAISILGKsLADELALVDVLEDKLKGEMM |
| P07195 | T323 | Sugiyama | LDHB | sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________ |
| P07237 | S427 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP |
| P07355 | S184 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK |
| P07737 | S30 | Sugiyama | PFN1 | NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV |
| P07814 | S1336 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | SEEDKEALIAKCNDYRRRLLsVNIRVRADLRDNysPGWKFN |
| P07814 | S739 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV |
| P07864 | S161 | Sugiyama | LDHC LDH3 LDHX | DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH |
| P07900 | S391 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV |
| P07900 | S50 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL |
| P07900 | S63 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN |
| P08174 | S106 | Sugiyama | CD55 CR DAF | QWSDIEEFCNRSCEVPtRLNsAsLKQPYITQNyFPVGtVVE |
| P08174 | S108 | Sugiyama | CD55 CR DAF | SDIEEFCNRSCEVPtRLNsAsLKQPYITQNyFPVGtVVEyE |
| P08238 | S383 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV |
| P08238 | S460 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ |
| P08238 | S462 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs |
| P08238 | S468 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG |
| P08238 | S470 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs |
| P08238 | S58 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| P08238 | Y457 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK |
| P08670 | S325 | Sugiyama | VIM | NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR |
| P09104 | S37 | Sugiyama | ENO2 | NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY |
| P09104 | S40 | Sugiyama | ENO2 | VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK |
| P09496 | S236 | Sugiyama | CLTA | RLCDFNPKSSKQAKDVSRMRsVLIsLKQAPLVH________ |
| P09496 | S240 | Sugiyama | CLTA | FNPKSSKQAKDVSRMRsVLIsLKQAPLVH____________ |
| P09497 | S217 | Sugiyama | CLTB | QLCDFNPKssKQCKDVSRLRsVLMsLKQTPLSR________ |
| P09497 | S221 | Sugiyama | CLTB | FNPKssKQCKDVSRLRsVLMsLKQTPLSR____________ |
| P0CAP2 | S179 | Sugiyama | POLR2M GRINL1A | RDRVPPSSEASEHHPRHRVssQAEDtSssFDNLFIDRLQRI |
| P0CG41 | S140 | Sugiyama | CTAGE8 | AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH |
| P0CG47 | S57 | Sugiyama | UBB | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM |
| P0CG48 | S57 | Sugiyama | UBC | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM |
| P0DPH7 | S54 | Sugiyama | TUBA3C TUBA2 | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| P11047 | S335 | Sugiyama | LAMC1 LAMB2 | DCEKCLPFFNDRPWRRAtAEsASECLPCDCNGRsQECyFDP |
| P11274 | S239 | Sugiyama | BCR BCR1 D22S11 | AGssVGDASRPPYRGRssEssCGVDGDyEDAELNPRFLKDN |
| P11831 | S103 | ELM|iPTMNet | SRF | sEsGEEEELGAERRGLKRsLsEMEIGMVVGGPEASAAATGG |
| P12956 | S520 | Sugiyama | XRCC6 G22P1 | PEQAVDLTLPKVEAMNKRLGsLVDEFKELVyPPDyNPEGKV |
| P13639 | S23 | Sugiyama | EEF2 EF2 | NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA |
| P13639 | S578 | Sugiyama | EEF2 EF2 | LKDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNK |
| P13639 | T582 | Sugiyama | EEF2 EF2 | EEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRL |
| P13639 | Y579 | Sugiyama | EEF2 EF2 | KDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKH |
| P13796 | S5 | EPSD|PSP | LCP1 PLS2 | ________________MARGsVsDEEMMELREAFAKVDtDG |
| P13798 | S8 | Sugiyama | APEH D3F15S2 D3S48E DNF15S2 | _____________MERQVLLsEPEEAAALyRGLSRQPALsA |
| P13861 | S58 | Sugiyama | PRKAR2A PKR2 PRKAR2 | TRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADAKGDs |
| P13861 | S99 | Sugiyama | PRKAR2A PKR2 PRKAR2 | EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI |
| P13929 | S37 | Sugiyama | ENO3 | NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY |
| P13929 | S40 | Sugiyama | ENO3 | VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK |
| P14314 | S126 | Sugiyama | PRKCSH G19P1 | yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE |
| P14618 | S97 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP |
| P14618 | T95 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | NFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTK |
| P14625 | S514 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK |
| P15336 | S62 | Sugiyama | ATF2 CREB2 CREBP1 | LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV |
| P15531 | S120 | Sugiyama | NME1 NDPKA NM23 | KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV |
| P16144 | S1364 | EPSD|PSP | ITGB4 | DSFLMYSDDVLRsPSGsQRPsVSDDTGCGWKFEPLLGEELD |
| P16220 | S119 | SIGNOR|PSP | CREB1 | EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE |
| P16333 | S85 | Sugiyama | NCK1 NCK | ASIVKNLKDTLGIGKVKRKPsVPDsAsPADDsFVDPGERLy |
| P17544 | S44 | Sugiyama | ATF7 ATFA | LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV |
| P17676 | T266 | ELM|iPTMNet|EPSD | CEBPB TCF5 PP9092 | TACyAGAAPAPsQVKSKAKKtVDKHSDEYKIRRERNNIAVR |
| P17812 | S587 | Sugiyama | CTPS1 CTPS | ysDRsGsssPDsEItELKFPsINHD________________ |
| P17987 | S544 | Sugiyama | TCP1 CCT1 CCTA | ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________ |
| P18615 | S113 | Sugiyama | NELFE RD RDBP | EGKLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLy |
| P18621 | S5 | Sugiyama | RPL17 | ________________MVRysLDPENPtKsCKSRGSNLRVH |
| P19338 | S458 | Sugiyama | NCL | TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN |
| P19338 | S460 | Sugiyama | NCL | ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST |
| P19338 | S580 | Sugiyama | NCL | PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI |
| P19634 | S703 | SIGNOR|ELM|EPSD|PSP | SLC9A1 APNH1 NHE1 | yLtVPAHKLDsPtMsRARIGsDPLAyEPKEDLPVItIDPAs |
| P20042 | S67 | Sugiyama | EIF2S2 EIF2B | EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK |
| P20810 | S366 | Sugiyama | CAST | DKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEKPS |
| P21333 | S2152 | SIGNOR|ELM|EPSD|PSP | FLNA FLN FLN1 | VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ |
| P22033 | S481 | Sugiyama | MMUT MUT | EGIPKLRIEECAARRQARIDsGSEVIVGVNKYQLEKEDAVE |
| P22087 | S124 | Sugiyama | FBL FIB1 FLRN | DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL |
| P22090 | S204 | Sugiyama | RPS4Y1 RPS4Y PRO2646 | IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN |
| P22314 | S46 | Sugiyama | UBA1 A1S9T UBE1 | AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA |
| P22736 | S351 | iPTMNet | NR4A1 GFRP1 HMR NAK1 | GMVKEVVRTDsLKGRRGRLPsKPKQPPDAsPANLLtSLVRA |
| P23142 | S247 | Sugiyama | FBLN1 PP213 | CRLGESCINTVGSFRCQRDssCGtGYELTEDNSCKDIDECE |
| P23381 | S139 | Sugiyama | WARS1 IFI53 WARS WRS | RIERATGQRPHHFLRRGIFFsHRDMNQVLDAyENKKPFYLY |
| P23381 | S351 | Sugiyama | WARS1 IFI53 WARS WRS | KPALLHSTFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTK |
| P23527 | S37 | Sugiyama | H2BC17 H2BFH H2BFN HIST1H2BO | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS |
| P23588 | S207 | Sugiyama | EIF4B | DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR |
| P23588 | S311 | Sugiyama | EIF4B | YRGGGDRYEDRYDRRDDRsWssRDDysRDDYRRDDRGPPQR |
| P23588 | S422 | SIGNOR|EPSD|PSP | EIF4B | ERHPsWRsEEtQERERsRtGsEssQtGtstTssRNARRREs |
| P23588 | S425 | PSP | EIF4B | PsWRsEEtQERERsRtGsEssQtGtstTssRNARRREsEKs |
| P23588 | S597 | Sugiyama | EIF4B | KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______ |
| P24534 | S141 | Sugiyama | EEF1B2 EEF1B EF1B | ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC |
| P25054 | S1389 | Sugiyama | APC DP2.5 | PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP |
| P25205 | S447 | Sugiyama | MCM3 | EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME |
| P25705 | S184 | Sugiyama | ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM | IGsKTRRRVGLKAPGIIPRIsVREPMQTGIKAVDsLVPIGR |
| P25788 | S243 | Sugiyama | PSMA3 HC8 PSC8 | GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________ |
| P25788 | Y239 | Sugiyama | PSMA3 HC8 PSC8 | ELTNGRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM____ |
| P25963 | S32 | iPTMNet|EPSD|PSP | NFKBIA IKBA MAD3 NFKBI | AMEGPRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEI |
| P26373 | T107 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF |
| P26641 | T287 | Sugiyama | EEF1G EF1G PRO1608 | EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL |
| P26885 | S108 | Sugiyama | FKBP2 FKBP13 | GWDQGLLGMCEGEKRKLVIPsELGyGERGAPPKIPGGATLV |
| P27348 | S63 | Sugiyama | YWHAQ | LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR |
| P27540 | S271 | Sugiyama | ARNT BHLHE2 | SSMRMCMGSRRSFICRMRCGsSSVDPVSVNRLSFVRNRCRN |
| P27708 | S1859 | Sugiyama | CAD | RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP |
| P27824 | S362 | Sugiyama | CANX | WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK |
| P28066 | S172 | Sugiyama | PSMA5 | QLFHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLK |
| P29317 | S897 | EPSD|PSP | EPHA2 ECK | APDSLKTLADFDPRVsIRLPstsGsEGVPFRTVsEWLESIK |
| P29401 | S104 | Sugiyama | TKT | AVWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGs |
| P29692 | S60 | Sugiyama | EEF1D EF1D | ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL |
| P30050 | S138 | Sugiyama | RPL12 | HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG |
| P30085 | S180 | Sugiyama | CMPK1 CMK CMPK UCK UMK UMPK | KPIIDLyEEMGKVKKIDASKsVDEVFDEVVQIFDKEG____ |
| P30086 | S52 | Sugiyama | PEBP1 PBP PEBP | AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD |
| P30304 | S293 | SIGNOR|EPSD|PSP | CDC25A | LKRPERsQEEsPPGSTKRRKsMsGASPKESTNPEKAHETLH |
| P30304 | S295 | SIGNOR|EPSD|PSP | CDC25A | RPERsQEEsPPGSTKRRKsMsGASPKESTNPEKAHETLHQS |
| P30305 | S353 | SIGNOR|EPSD|PSP | CDC25B CDC25HU2 | LKRLERPQDRDTPVQNKRRRsVtPPEEQQEAEEPKARVLRs |
| P30305 | T355 | SIGNOR|EPSD|PSP | CDC25B CDC25HU2 | RLERPQDRDTPVQNKRRRsVtPPEEQQEAEEPKARVLRsKs |
| P30307 | S247 | EPSD|PSP | CDC25C | KQVEKFKDNtIPDKVKKKYFsGQGKLRKGLCLKKtVsLCDI |
| P30533 | S242 | Sugiyama | LRPAP1 A2MRAP | TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD |
| P31150 | S213 | Sugiyama | GDI1 GDIL OPHN2 RABGDIA XAP4 | RTDDyLDQPCLETVNRIKLYsEsLARYGKsPYLyPLyGLGE |
| P31946 | S65 | Sugiyama | YWHAB | LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR |
| P32004 | S1152 | SIGNOR | L1CAM CAML1 MIC5 | LLLLVLLILCFIKRSKGGKysVKDKEDtQVDsEARPMKDEt |
| P32119 | S112 | Sugiyama | PRDX2 NKEFB TDPX1 | KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII |
| P32969 | S135 | Sugiyama | RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 | RNFLGEKYIRRVRMRPGVACsVsQAQKDELILEGNDIELVS |
| P33316 | S120 | Sugiyama | DUT | PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS |
| P33778 | S37 | Sugiyama | H2BC3 H2BFF HIST1H2BB | KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS |
| P34932 | S76 | Sugiyama | HSPA4 APG2 HSPH2 | VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT |
| P35269 | T154 | Sugiyama | GTF2F1 RAP74 | AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF |
| P35269 | T156 | Sugiyama | GTF2F1 RAP74 | EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI |
| P35568 | S1101 | ELM|EPSD | IRS1 | RNQSAKVIRADPQGCRRRHssEtFsstPSATRVGNTVPFGA |
| P35613 | S279 | Sugiyama | BSG UNQ6505/PRO21383 | TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy |
| P37802 | S163 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG |
| P37802 | S185 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______ |
| P37837 | S13 | Sugiyama | TALDO1 TAL TALDO TALDOR | ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA |
| P38606 | S384 | Sugiyama | ATP6V1A ATP6A1 ATP6V1A1 VPP2 | RLAEMPADSGYPAyLGARLAsFYERAGRVKCLGNPEREGSV |
| P38646 | S148 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | YDDPEVQKDIKNVPFKIVRAsNGDAWVEAHGKLYSPSQIGA |
| P39023 | S13 | Sugiyama | RPL3 OK/SW-cl.32 | ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP |
| P39023 | S265 | Sugiyama | RPL3 OK/SW-cl.32 | HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY |
| P42345 | S2448 | iPTMNet | MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 | NWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEPAH |
| P42345 | T2446 | iPTMNet | MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 | LLNWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEP |
| P42566 | S368 | Sugiyama | EPS15 AF1P | EKNNVEQDLKEKEDTIKQRtsEVQDLQDEVQRENTNLQKLQ |
| P42566 | S745 | Sugiyama | EPS15 AF1P | ADFSTLSKVNNEDPFRSATSssVsNVVITKNVFEETSVKSE |
| P43034 | S152 | Sugiyama | PAFAH1B1 LIS1 MDCR MDS PAFAHA | IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM |
| P43243 | S188 | Sugiyama | MATR3 KIAA0723 | EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs |
| P43354 | S347 | iPTMNet | NR4A2 NOT NURR1 TINUR | GMVKEVVRTDsLKGRRGRLPsKPKsPQEPsPPsPPVSLISA |
| P43487 | S60 | Sugiyama | RANBP1 | TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH |
| P45974 | S783 | Sugiyama | USP5 ISOT | IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL |
| P46527 | T198 | ELM | CDKN1B KIP1 p27 | sPNAGSVEQtPKKPGLRRRQt____________________ |
| P46776 | S68 | Sugiyama | RPL27A | yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV |
| P46937 | S109 | Sugiyama | YAP1 YAP65 | RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP |
| P46937 | T114 | Sugiyama | YAP1 YAP65 | sFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQL |
| P47712 | S727 | Sugiyama | PLA2G4A CPLA2 PLA2G4 | VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP |
| P47712 | S729 | Sugiyama | PLA2G4A CPLA2 PLA2G4 | KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA |
| P48643 | S270 | Sugiyama | CCT5 CCTE KIAA0098 | ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ |
| P49368 | S252 | Sugiyama | CCT3 CCTG TRIC5 | YIKNPRIVLLDssLEyKKGEsQtDIEITREEDFTRILQMEE |
| P49419 | S84 | Sugiyama | ALDH7A1 ATQ1 | EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD |
| P49427 | T162 | SIGNOR|EPSD|PSP | CDC34 UBCH3 UBE2R1 | VDASVMYRKWKESKGKDREYtDIIRKQVLGTKVDAERDGVK |
| P49815 | S1798 | SIGNOR|ELM|iPTMNet|EPSD|PSP | TSC2 TSC4 | AQTPAEPTPGyEVGQRKRLIssVEDFTEFV___________ |
| P49840 | T19 | Sugiyama | GSK3A | __MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGs |
| P49841 | S9 | SIGNOR|ELM|EPSD|PSP | GSK3B | ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS |
| P50395 | S213 | Sugiyama | GDI2 RABGDIB | RtDDyLDQPCyEtINRIKLYsEsLARYGKsPYLyPLyGLGE |
| P50454 | S139 | Sugiyama | SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 | SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS |
| P50549 | S191 | SIGNOR|ELM|iPTMNet|EPSD | ETV1 ER81 | PSQSIPDSSYPMDHRFRRQLsEPCNSFPPLPTMPREGRPMY |
| P50549 | S216 | SIGNOR|ELM|iPTMNet|EPSD | ETV1 ER81 | SFPPLPTMPREGRPMYQRQMsEPNIPFPPQGFKQEYHDPVY |
| P50549 | S334 | ELM|iPTMNet|EPSD | ETV1 ER81 | GDIKQEPGMYREGPTYQRRGsLQLWQFLVALLDDPSNSHFI |
| P50552 | T278 | SIGNOR|EPSD|PSP | VASP | SGGGGLMEEMNAMLARRRKAtQVGEKtPKDEsANQEEPEAR |
| P51116 | S601 | Sugiyama | FXR2 FMR1L2 | RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ |
| P51812 | S227 | Sugiyama | RPS6KA3 ISPK1 MAPKAPK1B RSK2 | IKLTDFGLSKESIDHEKKAysFCGtVEYMAPEVVNRRGHTQ |
| P51812 | T157 | Sugiyama | RPS6KA3 ISPK1 MAPKAPK1B RSK2 | FQTEGKLYLILDFLRGGDLFtRLSKEVMFTEEDVKFYLAEL |
| P51858 | S107 | Sugiyama | HDGF HMG1L2 | WEIENNPtVKASGYQSsQKKsCVEEPEPEPEAAEGDGDKKG |
| P52298 | S13 | Sugiyama | NCBP2 CBP20 PIG55 | ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE |
| P53355 | S289 | ELM|EPSD|PSP | DAPK1 DAPK | SLQHPWIKPKDTQQALSRKAsAVNMEKFKKFAARKKWKQsV |
| P53365 | S260 | Sugiyama | ARFIP2 POR1 | TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA |
| P53365 | S74 | Sugiyama | ARFIP2 POR1 | GYGGSGDGLIPTGSGRHPSHsTtPSGPGDEVARGIAGEKFD |
| P53396 | S455 | Sugiyama | ACLY | ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP |
| P53396 | S656 | Sugiyama | ACLY | IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR |
| P53621 | S266 | Sugiyama | COPA | RGHyNNVSCAVFHPRQELILsNsEDKSIRVWDMSKRTGVQT |
| P53999 | S56 | Sugiyama | SUB1 PC4 RPO2TC1 | PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD |
| P55060 | S342 | Sugiyama | CSE1L CAS XPO2 | ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF |
| P57053 | S37 | Sugiyama | H2BC12L H2BFS H2BS1 | KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| P58876 | S37 | Sugiyama | H2BC5 H2BFB HIRIP2 HIST1H2BD | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| P60174 | S212 | Sugiyama | TPI1 TPI | WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV |
| P60709 | S199 | Sugiyama | ACTB | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P60709 | S52 | Sugiyama | ACTB | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P60900 | S175 | Sugiyama | PSMA6 PROS27 | DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV |
| P60983 | T27 | ELM|iPTMNet|EPSD|PSP | GMFB | VCDVAEDLVEKLRKFRFRKEtNNAAIIMKIDKDKRLVVLDE |
| P61024 | S39 | Sugiyama | CKS1B CKS1 PNAS-143 PNAS-16 | yRHVMLPKDIAKLVPKTHLMsEsEWRNLGVQQsQGWVHyMI |
| P61024 | S41 | Sugiyama | CKS1B CKS1 PNAS-143 PNAS-16 | HVMLPKDIAKLVPKTHLMsEsEWRNLGVQQsQGWVHyMIHE |
| P61247 | S236 | Sugiyama | RPS3A FTE1 MFTL | KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy |
| P61313 | S100 | Sugiyama | RPL15 EC45 TCBAP0781 | tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW |
| P61916 | S29 | Sugiyama | NPC2 HE1 | LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL |
| P61978 | S75 | Sugiyama | HNRNPK HNRPK | GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE |
| P61981 | S64 | Sugiyama | YWHAG | LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA |
| P62249 | S9 | Sugiyama | RPS16 | ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN |
| P62263 | S137 | Sugiyama | RPS14 PRO2640 | RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______ |
| P62277 | S12 | Sugiyama | RPS13 | _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD |
| P62280 | S74 | Sugiyama | RPS11 | tyIDKKCPFTGNVsIRGRILsGVVTKMKMQRTIVIRRDYLH |
| P62701 | S204 | Sugiyama | RPS4X CCG2 RPS4 SCAR | tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN |
| P62736 | S54 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P62753 | S235 | SIGNOR|ELM|EPSD|PSP | RPS6 OK/SW-cl.2 | KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______ |
| P62753 | S236 | SIGNOR|ELM|EPSD|PSP | RPS6 OK/SW-cl.2 | RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______ |
| P62753 | S240 | SIGNOR | RPS6 OK/SW-cl.2 | AKEKRQEQIAKRRRLssLRAstsKsEssQK___________ |
| P62753 | S244 | SIGNOR | RPS6 OK/SW-cl.2 | RQEQIAKRRRLssLRAstsKsEssQK_______________ |
| P62807 | S37 | Sugiyama | H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI | KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss |
| P62906 | S64 | Sugiyama | RPL10A NEDD6 | QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH |
| P62917 | S130 | Sugiyama | RPL8 | GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL |
| P62979 | S123 | Sugiyama | RPS27A UBA80 UBCEP1 | LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK |
| P62979 | S57 | Sugiyama | RPS27A UBA80 UBCEP1 | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA |
| P62987 | S57 | Sugiyama | UBA52 UBCEP2 | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI |
| P63104 | S28 | Sugiyama | YWHAZ | QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy |
| P63261 | S199 | Sugiyama | ACTG1 ACTG | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P63261 | S52 | Sugiyama | ACTG1 ACTG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P63267 | S53 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P67809 | S102 | SIGNOR|EPSD|PSP|Sugiyama | YBX1 NSEP1 YB1 | EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA |
| P67809 | S209 | Sugiyama | YBX1 NSEP1 YB1 | RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ |
| P67809 | Y99 | Sugiyama | YBX1 NSEP1 YB1 | DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG |
| P68032 | S54 | Sugiyama | ACTC1 ACTC | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68133 | S54 | Sugiyama | ACTA1 ACTA | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68363 | S54 | Sugiyama | TUBA1B | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| P78346 | S251 | Sugiyama | RPP30 RNASEP2 | HGETRKTAFGIIsTVKKPRPsEGDEDCLPAsKKAKCEG___ |
| P78362 | S494 | Sugiyama | SRPK2 | GSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLLVN |
| P78371 | S143 | Sugiyama | CCT2 99D8.1 CCTB | PQTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIA |
| P78371 | S144 | Sugiyama | CCT2 99D8.1 CCTB | QTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIAG |
| P78371 | S260 | SIGNOR|EPSD|PSP | CCT2 99D8.1 CCTB | ANtGMDtDKIKIFGsRVRVDstAKVAEIEHAEKEKMKEKVE |
| P78371 | S470 | Sugiyama | CCT2 99D8.1 CCTB | IADNAGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAI |
| P84098 | S12 | Sugiyama | RPL19 | _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI |
| P84243 | S11 | SIGNOR | H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B | __________MARtKQTARKstGGKAPRKQLATKAARKsAP |
| Q00341 | S645 | Sugiyama | HDLBP HBP VGL | EtIIITGKRANCEAARSRILsIQKDLANIAEVEVSIPAKLH |
| Q00613 | S375 | Sugiyama | HSF1 HSTF1 | TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL |
| Q02543 | S123 | Sugiyama | RPL18A | AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK |
| Q02818 | S193 | Sugiyama | NUCB1 NUC | HEEFKRyEMLKEHERRRyLEsLGEEQRKEAERKLEEQQRRH |
| Q02818 | Y190 | Sugiyama | NUCB1 NUC | AAHHEEFKRyEMLKEHERRRyLEsLGEEQRKEAERKLEEQQ |
| Q02952 | S364 | Sugiyama | AKAP12 AKAP250 | EVAsEKLtAsEQAHPQEPAEsAHEPRLsAEyEKVELPsEEQ |
| Q04206 | S276 | PSP | RELA NFKB3 | PYADPsLQAPVRVsMQLRRPsDRELsEPMEFQYLPDTDDRH |
| Q04721 | S359 | Sugiyama | NOTCH2 | IDDCAFASCTPGSTCIDRVAsFSCMCPEGKAGLLCHLDDAC |
| Q04917 | S64 | Sugiyama | YWHAH YWHA1 | LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA |
| Q05195 | S145 | SIGNOR|EPSD|PSP | MXD1 MAD | EQRHLKRQLEKLGIERIRMDsIGSTVSSERSDSDREEIDVD |
| Q06210 | S261 | Sugiyama | GFPT1 GFAT GFPT | GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA |
| Q07021 | S213 | Sugiyama | C1QBP GC1QBP HABP1 SF2P32 | VGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDSLDW |
| Q07866 | S524 | Sugiyama | KLC1 KLC KNS2 | QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM |
| Q07889 | S1134 | EPSD|PSP | SOS1 | HSSNDTVFIQVTLPHGPRsAsVSSISLTKGTDEVPVPPPVP |
| Q07889 | S1161 | EPSD|PSP | SOS1 | TKGTDEVPVPPPVPPRRRPEsAPAEssPSKIMSKHLDsPPA |
| Q09028 | S146 | Sugiyama | RBBP4 RBAP48 | EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE |
| Q09161 | S22 | Sugiyama | NCBP1 CBP80 NCBP | SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS |
| Q09666 | S135 | Sugiyama | AHNAK PM227 | sGDDEEyQRIYttKIKPRLKsEDGVEGDLGEtQsRTITVTR |
| Q12792 | S140 | Sugiyama | TWF1 PTK9 | EVFGTVKEDVSLHGYKKyLLsQssPAPLtAAEEELRQIKIN |
| Q12982 | S114 | Sugiyama | BNIP2 NIP2 | EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR |
| Q13085 | S23 | Sugiyama | ACACA ACAC ACC1 ACCA | EPsPLAQPLELNQHSRFIIGsVsEDNsEDEISNLVKLDLLE |
| Q13164 | S496 | EPSD|PSP | MAPK7 BMK1 ERK5 PRKM7 | KAALKAALLKSLRSRLRDGPsAPLEAPEPRKPVTAQERQRE |
| Q13247 | S301 | Sugiyama | SRSF6 SFRS6 SRP55 | PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR |
| Q13263 | S473 | Sugiyama | TRIM28 KAP1 RNF96 TIF1B | sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL |
| Q13428 | S996 | Sugiyama | TCOF1 | AQAQAAstPRKARASESTARssssEsEDEDVIPAtQCLtPG |
| Q13442 | S19 | Sugiyama | PDAP1 HASPP28 | __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE |
| Q13442 | S57 | Sugiyama | PDAP1 HASPP28 | EEEQKEGGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGV |
| Q13442 | S60 | Sugiyama | PDAP1 HASPP28 | QKEGGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGL |
| Q13442 | T18 | Sugiyama | PDAP1 HASPP28 | ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE |
| Q13501 | S24 | Sugiyama | SQSTM1 ORCA OSIL | LTVKAYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPC |
| Q13501 | S28 | Sugiyama | SQSTM1 ORCA OSIL | AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL |
| Q13868 | S124 | Sugiyama | EXOSC2 RRP4 | LDSVLLLSSMNLPGGELRRRsAEDELAMRGFLQEGDLISAE |
| Q13884 | S225 | Sugiyama | SNTB1 SNT2B1 | sPVsEIGWEtPPPEsPRLGGstsDPPssQsFsFHRDRKSIP |
| Q14135 | S59 | Sugiyama | VGLL4 KIAA0121 | SALsSHRTGPPPIsPSKRKFsMEPGDEDLDCDNDHVSKMSR |
| Q14152 | S1028 | Sugiyama | EIF3A EIF3S10 KIAA0139 | NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP |
| Q14152 | S584 | Sugiyama | EIF3A EIF3S10 KIAA0139 | EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV |
| Q14160 | S1223 | Sugiyama | SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL | SPGVIANPFAAGIGHRNsLEsIssIDRELsPEGPGKEKELP |
| Q14320 | S292 | Sugiyama | FAM50A DXS9928E HXC26 XAP5 | ARGKsGPLFNFDVHDDVRLLsDATVEKDESHAGKVVLRSWY |
| Q14432 | T311 | Sugiyama | PDE3A | RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR |
| Q14568 | S50 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL |
| Q14671 | S709 | Sugiyama | PUM1 KIAA0099 PUMH1 | LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH |
| Q14697 | S187 | Sugiyama | GANAB G2AN KIAA0088 | LLsVNARGLLEFEHQRAPRVsQGsKDPAEGDGAQPEEtPRD |
| Q14738 | S573 | Sugiyama | PPP2R5D | TEAVQMLKDIKKEKVLLRRKsELPQDVyTIKALEAHKRAEE |
| Q14934 | S676 | ELM | NFATC4 NFAT3 | KRVSRPVQVYFYVSNGRRKRsPTQSFRFLPVICKEEPLPDS |
| Q14978 | S91 | Sugiyama | NOLC1 KIAA0035 NS5ATP13 | NGPVAKKAKKKAsssDsEDssEEEEEVQGPPAKKAAVPAKR |
| Q14C86 | S746 | Sugiyama | GAPVD1 GAPEX5 KIAA1521 RAP6 | APDLKQEERLQELEsCsGLGstSDDTDVREVSSRPSTPGLS |
| Q15021 | S1330 | Sugiyama | NCAPD2 CAPD2 CNAP1 KIAA0159 | sQRAPsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHP |
| Q15054 | S409 | Sugiyama | POLD3 KIAA0039 | SKTYLDGEGCIVTEKVyEsEsCtDsEEELNMKTSsVHRPPA |
| Q15054 | T411 | Sugiyama | POLD3 KIAA0039 | TYLDGEGCIVTEKVyEsEsCtDsEEELNMKTSsVHRPPAMT |
| Q15349 | T148 | Sugiyama | RPS6KA2 MAPKAPK1C RSK3 | FQTEGKLYLILDFLRGGDLFtRLSKEVMFTEEDVKFYLAEL |
| Q15418 | S221 | SIGNOR|ELM|EPSD|Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | IKLTDFGLSKEAIDHEKKAysFCGtVEYMAPEVVNRQGHSH |
| Q15418 | S307 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | TEAQSLLRALFKRNPANRLGsGPDGAEEIKRHVFYSTIDWN |
| Q15418 | S363 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | AQPDDTFYFDTEFTSRtPKDsPGIPPsAGAHQLFRGFsFVA |
| Q15418 | S369 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | FYFDTEFTSRtPKDsPGIPPsAGAHQLFRGFsFVAtGLMED |
| Q15418 | S380 | EPSD|Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | PKDsPGIPPsAGAHQLFRGFsFVAtGLMEDDGKPRAPQAPL |
| Q15418 | S402 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | VAtGLMEDDGKPRAPQAPLHsVVQQLHGKNLVFSDGYVVKE |
| Q15418 | S430 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | KNLVFSDGYVVKETIGVGSYsECKRCVHKATNMEYAVKVID |
| Q15418 | S45 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | TSGEEAGLQPSKDEGVLKEIsITHHVKAGSEKADPSHFELL |
| Q15418 | S528 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | SEREASFVLHTIGKTVEYLHsQGVVHRDLKPsNILYVDESG |
| Q15418 | S539 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | IGKTVEYLHsQGVVHRDLKPsNILYVDESGNPECLRICDFG |
| Q15418 | T151 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | FQTEGKLYLILDFLRGGDLFtRLSKEVMFTEEDVKFYLAEL |
| Q15418 | T384 | Sugiyama | RPS6KA1 MAPKAPK1A RSK1 | PGIPPsAGAHQLFRGFsFVAtGLMEDDGKPRAPQAPLHsVV |
| Q15428 | S153 | Sugiyama | SF3A2 SAP62 | LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA |
| Q15545 | S171 | Sugiyama | TAF7 TAF2F TAFII55 | TAKKKYIEsPDVEKEVKRLLstDAEAVSTRWEIIAEDETKE |
| Q15653 | S19 | ELM|EPSD | NFKBIB IKBB TRIP9 | __MAGVACLGKAADADEWCDsGLGsLGPDAAAPGGPGLGAE |
| Q15653 | S23 | ELM|EPSD | NFKBIB IKBB TRIP9 | GVACLGKAADADEWCDsGLGsLGPDAAAPGGPGLGAELGPG |
| Q15751 | S1514 | Sugiyama | HERC1 | AESRLVHtsPNYRLIKsRsEsDLsQPEsDEEGYALsGRRNV |
| Q15785 | S93 | Sugiyama | TOMM34 URCC3 | DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ |
| Q15818 | S91 | Sugiyama | NPTX1 | TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP |
| Q15831 | S428 | SIGNOR|ELM | STK11 LKB1 PJS | GRAPNPARKACSASSKIRRLsACKQQ_______________ |
| Q16204 | S323 | Sugiyama | CCDC6 D10S170 TST1 | RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ |
| Q16204 | S325 | Sugiyama | CCDC6 D10S170 TST1 | QRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGL |
| Q16513 | S583 | Sugiyama | PKN2 PRK2 PRKCL2 | VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs |
| Q16576 | S145 | Sugiyama | RBBP7 RBAP46 | EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE |
| Q16763 | T152 | Sugiyama | UBE2S E2EPF OK/SW-cl.73 | EAGRLLLENyEEyAARARLLtEIHGGAGGPSGRAEAGRALA |
| Q16778 | S37 | Sugiyama | H2BC21 H2BFQ HIST2H2BE | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss |
| Q16821 | S46 | SIGNOR|iPTMNet | PPP1R3A PP1G | CEDEEVTFQPGFSPQPSRRGsDsSEDIYLDTPSSGTRRVsF |
| Q16821 | S48 | ELM|EPSD | PPP1R3A PP1G | DEEVTFQPGFSPQPSRRGsDsSEDIYLDTPSSGTRRVsFAD |
| Q2M1Z3 | S1106 | EPSD|PSP | ARHGAP31 CDGAP KIAA1204 | AKLQLKSTECGPPKGKNRPssLNLDPAIPIADLFWFENVAS |
| Q2M1Z3 | S1178 | EPSD|PSP | ARHGAP31 CDGAP KIAA1204 | YSQDPQDLDIVAHALTGRRNsAPVSVSAVRTSFMVKMCQAR |
| Q4G0J3 | S258 | Sugiyama | LARP7 HDCMA18P | EENMDtsNtsIsKMKRsRPtsEGsDIEstEPQKQCSKKKKK |
| Q53EL6 | S457 | EPSD|PSP|Sugiyama | PDCD4 H731 | GIISKQLRDLCPSRGRKRFVsEGDGGRLKPESY________ |
| Q53EL6 | S76 | EPSD|PSP|Sugiyama | PDCD4 H731 | NAKAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPK |
| Q58FF6 | S34 | Sugiyama | HSP90AB4P | IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN |
| Q58FF7 | S58 | Sugiyama | HSP90AB3P HSP90BC | IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| Q58FF8 | S58 | Sugiyama | HSP90AB2P HSP90BB | IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN |
| Q5QNW6 | S37 | Sugiyama | H2BC18 HIST2H2BF | KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q5T0N5 | S488 | Sugiyama | FNBP1L C1orf39 TOCA1 | NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD |
| Q5T0N5 | S489 | Sugiyama | FNBP1L C1orf39 TOCA1 | EAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytDD |
| Q5T1M5 | S1162 | Sugiyama | FKBP15 KIAA0674 | EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP |
| Q5VUE5 | S67 | Sugiyama | C1orf53 | GNCGGSAPSTPGRPERAARPsVSEELTAAERQIAELHAAAC |
| Q66K14 | S1238 | Sugiyama | TBC1D9B KIAA0676 | EKRVDIGLKIKDQKKVERQFstAsDHEQPGVsG________ |
| Q6DN03 | S37 | Sugiyama | H2BC20P HIST2H2BC | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC |
| Q6DRA6 | S37 | Sugiyama | H2BC19P HIST2H2BD | KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC |
| Q6GYQ0 | T798 | Sugiyama | RALGAPA1 GARNL1 KIAA0884 TULIP1 | tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS |
| Q6L8Q7 | S266 | Sugiyama | PDE12 | LKLHCTPGDGQRFGHSRELEsVCVVEAGPGTCTFDHRHLYT |
| Q6P6C2 | S96 | Sugiyama | ALKBH5 ABH5 OFOXD1 | LQKEEEARKVKSGIRQMRLFsQDECAKIEARIDEVVSRAEK |
| Q6P996 | S722 | Sugiyama | PDXDC1 KIAA0251 | PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI |
| Q6PEY2 | S54 | Sugiyama | TUBA3E | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| Q6ZMR3 | S161 | Sugiyama | LDHAL6A LDHL2 | DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH |
| Q6ZN18 | S206 | Sugiyama | AEBP2 | DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS |
| Q6ZUT9 | S691 | Sugiyama | DENND5B | NRWVSRSATAQRRKERLRQHsEHVGLDNDLREKYMQEARSL |
| Q71U36 | S54 | Sugiyama | TUBA1A TUBA3 | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| Q76FK4 | S296 | Sugiyama | NOL8 C9orf34 NOP132 | QKLKNLPFKTSGLETAKKRNsIsDDDtDsEDELRMMIAKEE |
| Q7KZF4 | S150 | Sugiyama | SND1 TDRD11 | EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS |
| Q7Z4V5 | S300 | Sugiyama | HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 | AEKPLPKPRGRKPKPERPPSssSSDSDSDEVDRISEWKRRD |
| Q7Z4V5 | S369 | Sugiyama | HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 | EKERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGR |
| Q7Z4V5 | S395 | Sugiyama | HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 | REDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKK |
| Q7Z4V5 | S454 | Sugiyama | HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 | VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK |
| Q7Z5L9 | S240 | Sugiyama | IRF2BP2 | AAASLGSAQPTDLGAHKRPAsVsssAAVEHEQREAAAKEKQ |
| Q7Z5L9 | S457 | Sugiyama | IRF2BP2 | GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ |
| Q86UF2 | S140 | Sugiyama | CTAGE6 CTAGE6P | AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH |
| Q86UU0 | S118 | Sugiyama | BCL9L DLNB11 | QAGVPPFssLKGKVKRDRsVsVDsGEQREAGtPsLDSEAKE |
| Q8IX03 | S947 | SIGNOR|EPSD|PSP | WWC1 KIAA0869 KIBRA | sKtFsPGPQSQYVCRLNRsDsDsSTLSKKPPFVRNSLERRS |
| Q8IX03 | T929 | SIGNOR|EPSD|PSP | WWC1 KIAA0869 KIBRA | RVGtPsQGPFLRGSTIIRsKtFsPGPQSQYVCRLNRsDsDs |
| Q8IX94 | S140 | Sugiyama | CTAGE4 | AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH |
| Q8N122 | S719 | SIGNOR|ELM|EPSD|PSP | RPTOR KIAA1303 RAPTOR | TTEGGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSL |
| Q8N122 | S721 | SIGNOR|EPSD|PSP | RPTOR KIAA1303 RAPTOR | EGGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQN |
| Q8N122 | S722 | SIGNOR|ELM|EPSD|PSP | RPTOR KIAA1303 RAPTOR | GGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQNL |
| Q8N201 | S495 | Sugiyama | INTS1 KIAA1440 UNQ1821/PRO3434 | KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF |
| Q8N257 | S37 | Sugiyama | H2BC26 H2BU1 HIST3H2BB | KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss |
| Q8NBJ5 | S607 | Sugiyama | COLGALT1 GLT25D1 PSEC0241 | DRAKSQKMREQQALSREAKNsDVLQsPLDsAARDEL_____ |
| Q8NBJ7 | S256 | Sugiyama | SUMF2 PSEC0171 UNQ1968/PRO4500 | EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG |
| Q8NBS9 | S285 | Sugiyama | TXNDC5 TLP46 UNQ364/PRO700 | LLWFRDGKKVDQYKGKRDLEsLREyVEsQLQRTETGATETV |
| Q8NI08 | S209 | Sugiyama | NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 | KLPDADLARKALKPIERVLsstsEEDEPGVVKFLKMNCRYF |
| Q8TB45 | S286 | SIGNOR|EPSD|PSP | DEPTOR DEPDC6 | PsKEIKIVSAVRRssMssCGssGyFsssPtLsssPPVLCNP |
| Q8TB45 | S287 | SIGNOR|EPSD|PSP | DEPTOR DEPDC6 | sKEIKIVSAVRRssMssCGssGyFsssPtLsssPPVLCNPK |
| Q8TB45 | S291 | SIGNOR|EPSD|PSP | DEPTOR DEPDC6 | KIVSAVRRssMssCGssGyFsssPtLsssPPVLCNPKSVLK |
| Q8TBC4 | S417 | Sugiyama | UBA3 UBE1C | MKsPAItATLEGKNRTLYLQsVTsIEERTRPNLSKTLKELG |
| Q8TCD5 | S182 | Sugiyama | NT5C DNT1 UMPH2 | LFTCCHNRHLVLPPTRRRLLsWsDNWREILDSKRGAAQRE_ |
| Q8TD16 | S658 | Sugiyama | BICD2 KIAA0699 | IKHLQAAVDRTTELSRQRIAsQELGPAVDKDKEALMEEILK |
| Q8TEH3 | S538 | Sugiyama | DENND1A FAM31A KIAA1608 | RtsVPsPEQPQPYRtLREsDsAEGDEAEsPEQQVRKstGPV |
| Q8TEW0 | S962 | Sugiyama | PARD3 PAR3 PAR3A | DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ |
| Q8WVC0 | S294 | Sugiyama | LEO1 RDL | ARGsDsEDEVLRMKRKNAIAsDsEADsDtEVPKDNSGTMDL |
| Q92570 | S376 | SIGNOR|iPTMNet | NR4A3 CHN CSMF MINOR NOR1 TEC | GMVKEVVRTDsLKGRRGRLPsKPKsPLQQEPsQPsPPsPPI |
| Q92597 | S330 | Sugiyama | NDRG1 CAP43 DRG1 RTP | QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT |
| Q92609 | S43 | Sugiyama | TBC1D5 KIAA0210 | PLSSYSNKSGGDSNKNGRRtsstLDsEGTFNSYRKEWEELF |
| Q92609 | S44 | Sugiyama | TBC1D5 KIAA0210 | LSSYSNKSGGDSNKNGRRtsstLDsEGTFNSYRKEWEELFV |
| Q92731 | S165 | ELM|EPSD | ESR2 ESTRB NR3A2 | DAHFCAVCSDYASGYHYGVWsCEGCKAFFKRsIQGHNDYIC |
| Q92734 | S50 | Sugiyama | TFG | DITyDELVLMMQRVFRGKLLsNDEVTIKYKDEDGDLITIFD |
| Q92882 | S202 | SIGNOR|EPSD|PSP | OSTF1 | NAACAsLLKKKQGTDAVRtLsNAEDyLDDEDsD________ |
| Q92934 | S118 | SIGNOR|ELM|iPTMNet|EPSD | BAD BBC6 BCL2L8 | RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA |
| Q92934 | S153 | SIGNOR|iPTMNet | BAD BBC6 BCL2L8 | KsAGtATQMRQSSSWTRVFQsWWDRNLGRGSSAPSQ_____ |
| Q92934 | S75 | SIGNOR|ELM|iPTMNet|EPSD|PSP | BAD BBC6 BCL2L8 | PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG |
| Q92934 | S99 | ELM | BAD BBC6 BCL2L8 | GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD |
| Q93079 | S37 | Sugiyama | H2BC9 H2BFJ HIST1H2BH | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q96CV9 | S526 | Sugiyama | OPTN FIP2 GLC1E HIP7 HYPL NRP | FEDGGRQsLMEMQsRHGARtsDsDQQAyLVQRGAEDRDWRQ |
| Q96CV9 | T525 | Sugiyama | OPTN FIP2 GLC1E HIP7 HYPL NRP | AFEDGGRQsLMEMQsRHGARtsDsDQQAyLVQRGAEDRDWR |
| Q96CW6 | S32 | Sugiyama | SLC7A6OS | KRKRsAEPAEALVLACKRLRsDAVESAAQKTSEGLERAAEN |
| Q96D15 | S117 | Sugiyama | RCN3 UNQ239/PRO272 | VsLAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEE |
| Q96D71 | S709 | PSP | REPS1 | VSKGttPLAPPPKPVRRRLKsEDELRPEVDEHtQKTGVLAA |
| Q96G46 | T240 | Sugiyama | DUS3L | KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC |
| Q96MH2 | S51 | Sugiyama | HEXIM2 L3 | QtPPERHDsGGsLPLtPRMEsHsEDEDLAGAVGGLGWNsRs |
| Q96P48 | S429 | Sugiyama | ARAP1 CENTD2 KIAA0782 | EWMQALQQAMAEQRARARLssAyLLGVPGSEQPDRAGSLEL |
| Q96QZ7 | S741 | SIGNOR|PSP | MAGI1 AIP3 BAIAP1 BAP1 TNRC19 | RGGLPVPKKsPKSQPLERKDsQNSSQHSVSSHRsLHtAsPs |
| Q96RU3 | Y500 | Sugiyama | FNBP1 FBP17 KIAA0554 | AEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREsPDG |
| Q96ST2 | S415 | Sugiyama | IWS1 IWS1L | AVLsDsEDEEKAsAKKSRVVsDADDsDsDAVsDKsGKREKt |
| Q96T58 | S1268 | Sugiyama | SPEN KIAA0929 MINT SHARP | SRQISEDsERtGGsPsVRHGsFHEDEDPIGsPRLLSVKGsP |
| Q99613 | S865 | Sugiyama | EIF3C EIF3S8 | HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF |
| Q99877 | S37 | Sugiyama | H2BC15 H2BFD HIST1H2BN | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99879 | S37 | Sugiyama | H2BC14 H2BFE HIST1H2BM | KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99880 | S37 | Sugiyama | H2BC13 H2BFC HIST1H2BL | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q9BQA1 | S185 | Sugiyama | WDR77 MEP50 WD45 HKMT1069 Nbla10071 | AHAAQVTCVAAsPHKDSVFLsCSEDNRILLWDTRCPKPASQ |
| Q9BQE3 | S54 | Sugiyama | TUBA1C TUBA6 | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| Q9BTC0 | S1456 | Sugiyama | DIDO1 C20orf158 DATF1 KIAA0333 | EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ |
| Q9BVS4 | S483 | PSP | RIOK2 RIO2 | RPFRDEENVGAMNQYRTRtLsItssGsAVSCSTIPPELVKQ |
| Q9BW71 | S357 | Sugiyama | HIRIP3 | EDsGKGEPTAKGSRKMARLGstsGEEsDLEREVsDsEAGGG |
| Q9BY44 | S526 | Sugiyama | EIF2A CDA02 MSTP004 MSTP089 | sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA |
| Q9BYX2 | S915 | Sugiyama | TBC1D2 PARIS1 PP8997 TBC1D2A | ELEQLKAEyLERRASRRRAVsEGCAsEDEVEGEA_______ |
| Q9BZL6 | S197 | Sugiyama | PRKD2 PKD2 HSPC187 | HKRCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPC |
| Q9BZL6 | S198 | Sugiyama | PRKD2 PKD2 HSPC187 | KRCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPCT |
| Q9BZL6 | T199 | Sugiyama | PRKD2 PKD2 HSPC187 | RCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPCTA |
| Q9C0C2 | S1620 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | ADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRMsLGT |
| Q9H0B6 | S428 | Sugiyama | KLC2 | NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV |
| Q9H1K0 | S548 | Sugiyama | RBSN ZFYVE20 | RELEREREQFRVASLHTRTRsLDFREIGPFQLEPSREPRTH |
| Q9H2U2 | S313 | Sugiyama | PPA2 HSPC124 | VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG |
| Q9H3H1 | S431 | Sugiyama | TRIT1 IPT MOD5 | AAHIKSKSHLNQLKKRRRLDsDAVNTIEsQsVsPDHNKEPK |
| Q9H3N1 | S226 | Sugiyama | TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 | LCPSKRRRPQPYPYPSKKLLsEsAQPLKKVEEEQEADEEDV |
| Q9H3Q1 | S309 | Sugiyama | CDC42EP4 BORG4 CEP4 | AAPsPGsARSMGSHTTRDSSsLssCtsGILEERsPAFRGPD |
| Q9H4A4 | S19 | Sugiyama | RNPEP APB | __MAsGEHsPGsGAARRPLHsAQAVDVAsAsNFRAFELLHL |
| Q9H6Z4 | S126 | SIGNOR|EPSD|PSP | RANBP3 | EDsDREDGNyCPPVKRERtssLtQFPPSQSEERSSGFRLKP |
| Q9H6Z4 | S57 | SIGNOR | RANBP3 | SGEEPRGEAEAPHHGTGHPEsAGEHALEPPAPAGASASTPP |
| Q9H788 | S315 | Sugiyama | SH2D4A PPP1R38 SH2A | LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA |
| Q9H788 | S316 | Sugiyama | SH2D4A PPP1R38 SH2A | NSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRAG |
| Q9H7D7 | S121 | Sugiyama | WDR26 CDW2 MIP2 PRO0852 | ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN |
| Q9HAU0 | S471 | Sugiyama | PLEKHA5 KIAA1686 PEPP2 | MARYPEGYRtLPRNSKTRPEsICSVtPsTHDKTLGPGAEEK |
| Q9HC62 | T369 | SIGNOR|EPSD|PSP | SENP2 KIAA1331 | KEKNCSGKERDRRTDDLLELtEDMEKEISNALGHGPQDEIL |
| Q9HCN4 | S301 | Sugiyama | GPN1 MBDIN RPAP4 XAB1 HUSSY-23 | ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD |
| Q9NP61 | S367 | Sugiyama | ARFGAP3 ARFGAP1 | DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT |
| Q9NQX3 | S262 | Sugiyama | GPHN GPH KIAA1385 | AKIPDSIISRGVQVLPRDTAsLsttPsEsPRAQAtsRLstA |
| Q9NQY0 | S248 | Sugiyama | BIN3 | HSDEQRERENEAKLSELRALsIVADD_______________ |
| Q9NRA8 | S353 | Sugiyama | EIF4ENIF1 | SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL |
| Q9NTI5 | S1257 | Sugiyama | PDS5B APRIN AS3 KIAA0979 | LVQEQKPKGSQRSRKRGHtAsEsDEQQWPEEKRLKEDILEN |
| Q9NUP9 | S142 | Sugiyama | LIN7C MALS3 VELI3 | IIPGGIADRHGGLKRGDQLLsVNGVSVEGEHHEKAVELLKA |
| Q9NUU7 | T467 | Sugiyama | DDX19A DDX19L | SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________ |
| Q9NW13 | S200 | Sugiyama | RBM28 | KGRTVAVDWAVAKDKYKDTQsVsAIGEEKSHESKHQESVKK |
| Q9NY33 | S130 | Sugiyama | DPP3 | GDTKFVPNLPKEKLERVILGsEAAQQHPEEVRGLWQTCGEL |
| Q9NYB0 | S205 | PSP | TERF2IP DRIP5 RAP1 PP8000 | LKHLRGQEHKyLLGDAPVsPssQKLKRKAEEDPEAADsGEP |
| Q9NZZ3 | S16 | Sugiyama | CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2 | _____MNRLFGKAKPKAPPPsLtDCIGtVDsRAEsIDKKIS |
| Q9UBP6 | S27 | SIGNOR|iPTMNet|EPSD|PSP|Sugiyama | METTL1 C12orf1 | NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS |
| Q9UGV2 | S331 | Sugiyama | NDRG3 | QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ |
| Q9UGV2 | S335 | Sugiyama | NDRG3 | YIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGt |
| Q9UGV2 | T332 | Sugiyama | NDRG3 | GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs |
| Q9UI15 | S185 | Sugiyama | TAGLN3 NP25 | EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______ |
| Q9UK32 | S232 | Sugiyama | RPS6KA6 RSK4 | IKLTDFGLSKEsVDQEKKAysFCGtVEYMAPEVVNRRGHSQ |
| Q9UKV3 | S240 | Sugiyama | ACIN1 ACINUS KIAA0670 | KPRKGERRSSRVRQARAAKLsEGsQPAEEEEDQEtPsRNLR |
| Q9ULL1 | S611 | Sugiyama | PLEKHG1 KIAA1209 | GQMESTETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTREL |
| Q9UMR2 | T468 | Sugiyama | DDX19B DBP5 DDX19 TDBP | SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________ |
| Q9UN36 | S332 | EPSD|PSP | NDRG2 KIAA1248 SYLD | QGMGYMASSCMTRLsRsRtAsLtsAAsVDGNRsRsRtLsQs |
| Q9UN36 | S350 | EPSD|PSP | NDRG2 KIAA1248 SYLD | tAsLtsAAsVDGNRsRsRtLsQssEsGtLsSGPPGHTMEVS |
| Q9UPQ0 | S377 | Sugiyama | LIMCH1 KIAA1102 | LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA |
| Q9UQ35 | S1541 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs |
| Q9UQ35 | S854 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sHSsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFE |
| Q9Y2B0 | S65 | Sugiyama | CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 | VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI |
| Q9Y2T7 | S137 | Sugiyama | YBX2 CSDA3 MSY2 | EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA |
| Q9Y2V2 | S52 | SIGNOR|EPSD|PSP|Sugiyama | CARHSP1 | sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR |
| Q9Y2X7 | S592 | Sugiyama | GIT1 | PLLsCsQEGsRHtsKLsRHGsGADsDyENtQSGDPLLGLEG |
| Q9Y5S9 | S56 | Sugiyama | RBM8A RBM8 HSPC114 MDS014 | KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF |
| Q9Y6D5 | S277 | Sugiyama | ARFGEF2 ARFGEP2 BIG2 | RSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDVV |
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 1.267058e-07 | 6.897 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 9.526895e-07 | 6.021 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 1.363118e-06 | 5.865 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 1.595727e-06 | 5.797 | 1 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 2.613275e-06 | 5.583 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 4.190309e-06 | 5.378 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 2.087961e-05 | 4.680 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 2.578829e-05 | 4.589 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 6.222490e-05 | 4.206 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 1.194531e-04 | 3.923 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 1.288155e-04 | 3.890 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 1.268866e-04 | 3.897 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 1.279553e-04 | 3.893 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 1.395610e-04 | 3.855 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 1.741551e-04 | 3.759 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 1.816329e-04 | 3.741 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 2.850779e-04 | 3.545 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 3.335852e-04 | 3.477 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 6.580264e-04 | 3.182 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 7.451531e-04 | 3.128 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 7.339287e-04 | 3.134 | 1 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 7.512245e-04 | 3.124 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 7.902279e-04 | 3.102 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 9.472913e-04 | 3.024 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 9.552611e-04 | 3.020 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 1.036660e-03 | 2.984 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 1.058049e-03 | 2.975 | 1 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 1.135828e-03 | 2.945 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 1.391231e-03 | 2.857 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 1.436209e-03 | 2.843 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 1.436209e-03 | 2.843 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 1.714857e-03 | 2.766 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 1.993268e-03 | 2.700 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 1.943772e-03 | 2.711 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 2.222621e-03 | 2.653 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 2.301053e-03 | 2.638 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 2.271854e-03 | 2.644 | 1 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 2.369044e-03 | 2.625 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 2.560413e-03 | 2.592 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 2.835130e-03 | 2.547 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 2.835130e-03 | 2.547 | 0 | 0 |
| GLI proteins bind promoters of Hh responsive genes to promote transcription | R-HSA-5635851 | 2.835130e-03 | 2.547 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 2.747221e-03 | 2.561 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 3.197118e-03 | 2.495 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 3.210236e-03 | 2.493 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 3.330899e-03 | 2.477 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 3.399820e-03 | 2.469 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 3.678632e-03 | 2.434 | 0 | 0 |
| M Phase | R-HSA-68886 | 3.845282e-03 | 2.415 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 3.751660e-03 | 2.426 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 3.873738e-03 | 2.412 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 4.101044e-03 | 2.387 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 4.101044e-03 | 2.387 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 4.329724e-03 | 2.364 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 4.527814e-03 | 2.344 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 4.612804e-03 | 2.336 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 4.687988e-03 | 2.329 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 4.942525e-03 | 2.306 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 4.955034e-03 | 2.305 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 5.427374e-03 | 2.265 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 5.670606e-03 | 2.246 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 6.092516e-03 | 2.215 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 6.092516e-03 | 2.215 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 6.618608e-03 | 2.179 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | R-HSA-2892245 | 7.151926e-03 | 2.146 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 6.910294e-03 | 2.161 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 7.024135e-03 | 2.153 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 7.153782e-03 | 2.145 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 7.153782e-03 | 2.145 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 7.606155e-03 | 2.119 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 7.606155e-03 | 2.119 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 1.001930e-02 | 1.999 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 9.736909e-03 | 2.012 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 9.669085e-03 | 2.015 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 9.669085e-03 | 2.015 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 9.736909e-03 | 2.012 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 9.569150e-03 | 2.019 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 1.066725e-02 | 1.972 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 1.072691e-02 | 1.970 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 1.049224e-02 | 1.979 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 1.033175e-02 | 1.986 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 1.047727e-02 | 1.980 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 1.116148e-02 | 1.952 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 1.174317e-02 | 1.930 | 0 | 0 |
| RUNX3 regulates RUNX1-mediated transcription | R-HSA-8951911 | 1.226895e-02 | 1.911 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 1.257196e-02 | 1.901 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 1.305694e-02 | 1.884 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 1.320921e-02 | 1.879 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | R-HSA-2892247 | 1.337717e-02 | 1.874 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 1.349209e-02 | 1.870 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 1.512238e-02 | 1.820 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 1.474520e-02 | 1.831 | 0 | 0 |
| PKA-mediated phosphorylation of key metabolic factors | R-HSA-163358 | 1.560491e-02 | 1.807 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 1.638224e-02 | 1.786 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 1.674685e-02 | 1.776 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 1.700883e-02 | 1.769 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 1.750368e-02 | 1.757 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 1.758273e-02 | 1.755 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 1.918677e-02 | 1.717 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 2.077676e-02 | 1.682 | 0 | 0 |
| PKA activation | R-HSA-163615 | 2.077676e-02 | 1.682 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 2.077676e-02 | 1.682 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 2.064484e-02 | 1.685 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 2.021279e-02 | 1.694 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 2.119772e-02 | 1.674 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 2.119772e-02 | 1.674 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 2.148454e-02 | 1.668 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 2.199362e-02 | 1.658 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 2.217777e-02 | 1.654 | 1 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 2.276585e-02 | 1.643 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 2.280143e-02 | 1.642 | 0 | 0 |
| Loss of MECP2 binding ability to 5hmC-DNA | R-HSA-9022534 | 2.372617e-02 | 1.625 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 2.393834e-02 | 1.621 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 2.472953e-02 | 1.607 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 2.504579e-02 | 1.601 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 2.525788e-02 | 1.598 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 2.663579e-02 | 1.575 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 2.787413e-02 | 1.555 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 2.848583e-02 | 1.545 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 2.919407e-02 | 1.535 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 2.919407e-02 | 1.535 | 0 | 0 |
| RUNX2 regulates genes involved in differentiation of myeloid cells | R-HSA-8941333 | 3.490160e-02 | 1.457 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 3.490160e-02 | 1.457 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 3.179602e-02 | 1.498 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 3.393626e-02 | 1.469 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 3.292620e-02 | 1.482 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 3.282052e-02 | 1.484 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 3.380045e-02 | 1.471 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 3.380045e-02 | 1.471 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 3.061673e-02 | 1.514 | 0 | 0 |
| Transcriptional activation of cell cycle inhibitor p21 | R-HSA-69895 | 3.490160e-02 | 1.457 | 0 | 0 |
| Transcriptional activation of p53 responsive genes | R-HSA-69560 | 3.490160e-02 | 1.457 | 0 | 0 |
| Dopamine receptors | R-HSA-390651 | 3.490160e-02 | 1.457 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 3.396686e-02 | 1.469 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 3.396686e-02 | 1.469 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 3.292620e-02 | 1.482 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 3.717726e-02 | 1.430 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 3.766959e-02 | 1.424 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 3.766959e-02 | 1.424 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 4.255646e-02 | 1.371 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 4.255646e-02 | 1.371 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 4.269936e-02 | 1.370 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 4.269936e-02 | 1.370 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 4.010748e-02 | 1.397 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 4.321512e-02 | 1.364 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 4.086128e-02 | 1.389 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 4.321512e-02 | 1.364 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 4.087082e-02 | 1.389 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 4.255646e-02 | 1.371 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 4.255646e-02 | 1.371 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 4.443229e-02 | 1.352 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 4.446514e-02 | 1.352 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 4.731213e-02 | 1.325 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 4.761278e-02 | 1.322 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 4.761278e-02 | 1.322 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 4.767923e-02 | 1.322 | 0 | 0 |
| Interactions of Tat with host cellular proteins | R-HSA-176034 | 4.945419e-02 | 1.306 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 5.092611e-02 | 1.293 | 0 | 0 |
| RUNX2 regulates chondrocyte maturation | R-HSA-8941284 | 5.092611e-02 | 1.293 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 5.092611e-02 | 1.293 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 5.092611e-02 | 1.293 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 5.092611e-02 | 1.293 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 5.092611e-02 | 1.293 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 4.820878e-02 | 1.317 | 0 | 0 |
| NrCAM interactions | R-HSA-447038 | 5.092611e-02 | 1.293 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 5.305942e-02 | 1.275 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 5.055653e-02 | 1.296 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 5.358794e-02 | 1.271 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 5.389106e-02 | 1.268 | 1 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 5.465830e-02 | 1.262 | 0 | 0 |
| NFE2L2 regulating MDR associated enzymes | R-HSA-9818032 | 5.512359e-02 | 1.259 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 5.512359e-02 | 1.259 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 5.574801e-02 | 1.254 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 5.622077e-02 | 1.250 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 5.717185e-02 | 1.243 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 5.724962e-02 | 1.242 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 5.724962e-02 | 1.242 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 6.432116e-02 | 1.192 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 6.165417e-02 | 1.210 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 6.165417e-02 | 1.210 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 6.725695e-02 | 1.172 | 0 | 0 |
| cGMP effects | R-HSA-418457 | 6.395751e-02 | 1.194 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 6.686072e-02 | 1.175 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 6.191943e-02 | 1.208 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 6.518579e-02 | 1.186 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 6.621677e-02 | 1.179 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 6.578974e-02 | 1.182 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 6.866136e-02 | 1.163 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 6.903842e-02 | 1.161 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 6.989167e-02 | 1.156 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 6.989167e-02 | 1.156 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 6.989167e-02 | 1.156 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 6.989167e-02 | 1.156 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 7.120844e-02 | 1.147 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 8.151188e-02 | 1.089 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 8.151188e-02 | 1.089 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 8.151188e-02 | 1.089 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 8.151188e-02 | 1.089 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 8.151188e-02 | 1.089 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 8.151188e-02 | 1.089 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 8.151188e-02 | 1.089 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 8.151188e-02 | 1.089 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 8.151188e-02 | 1.089 | 0 | 0 |
| Potassium transport channels | R-HSA-1296067 | 8.151188e-02 | 1.089 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 8.151188e-02 | 1.089 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 8.151188e-02 | 1.089 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 8.151188e-02 | 1.089 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 8.151188e-02 | 1.089 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 7.645335e-02 | 1.117 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 7.645335e-02 | 1.117 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 7.645335e-02 | 1.117 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 7.727960e-02 | 1.112 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 7.727960e-02 | 1.112 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 8.024788e-02 | 1.096 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 7.184117e-02 | 1.144 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 7.201172e-02 | 1.143 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 8.151188e-02 | 1.089 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 8.092511e-02 | 1.092 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 7.209769e-02 | 1.142 | 1 | 1 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 8.024788e-02 | 1.096 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 7.605718e-02 | 1.119 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 7.605718e-02 | 1.119 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 7.570965e-02 | 1.121 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 8.191890e-02 | 1.087 | 1 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 8.332943e-02 | 1.079 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 8.394859e-02 | 1.076 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 1.110779e-01 | 0.954 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 2.098233e-01 | 0.678 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 2.098233e-01 | 0.678 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 2.098233e-01 | 0.678 | 0 | 0 |
| Impaired BRCA2 translocation to the nucleus | R-HSA-9709275 | 2.098233e-01 | 0.678 | 0 | 0 |
| Defective DNA double strand break response due to BARD1 loss of function | R-HSA-9699150 | 2.098233e-01 | 0.678 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 2.098233e-01 | 0.678 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 2.098233e-01 | 0.678 | 0 | 0 |
| Impaired BRCA2 binding to SEM1 (DSS1) | R-HSA-9763198 | 2.098233e-01 | 0.678 | 0 | 0 |
| Defective DNA double strand break response due to BRCA1 loss of function | R-HSA-9663199 | 2.098233e-01 | 0.678 | 0 | 0 |
| Loss of MECP2 binding ability to 5mC-DNA | R-HSA-9022538 | 1.181771e-01 | 0.927 | 0 | 0 |
| Invadopodia formation | R-HSA-8941237 | 1.181771e-01 | 0.927 | 0 | 0 |
| MECP2 regulates transcription of genes involved in GABA signaling | R-HSA-9022927 | 1.580318e-01 | 0.801 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 1.580318e-01 | 0.801 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 1.580318e-01 | 0.801 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 1.580318e-01 | 0.801 | 0 | 0 |
| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | R-HSA-2644607 | 1.580318e-01 | 0.801 | 0 | 0 |
| FBXW7 Mutants and NOTCH1 in Cancer | R-HSA-2644605 | 1.580318e-01 | 0.801 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 1.580318e-01 | 0.801 | 0 | 0 |
| PI and PC transport between ER and Golgi membranes | R-HSA-1483196 | 2.976048e-01 | 0.526 | 0 | 0 |
| TGFBR3 regulates FGF2 signaling | R-HSA-9839397 | 2.976048e-01 | 0.526 | 0 | 0 |
| Intestinal infectious diseases | R-HSA-8942233 | 2.976048e-01 | 0.526 | 0 | 0 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 2.976048e-01 | 0.526 | 0 | 0 |
| SMAD2/3 MH2 Domain Mutants in Cancer | R-HSA-3315487 | 2.976048e-01 | 0.526 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 2.976048e-01 | 0.526 | 0 | 0 |
| Signaling by TCF7L2 mutants | R-HSA-5339700 | 2.976048e-01 | 0.526 | 0 | 0 |
| SMAD4 MH2 Domain Mutants in Cancer | R-HSA-3311021 | 2.976048e-01 | 0.526 | 0 | 0 |
| MyD88 deficiency (TLR5) | R-HSA-5602680 | 2.976048e-01 | 0.526 | 0 | 0 |
| Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | R-HSA-5619111 | 2.976048e-01 | 0.526 | 0 | 0 |
| TWIK-releated acid-sensitive K+ channel (TASK) | R-HSA-1299316 | 2.976048e-01 | 0.526 | 0 | 0 |
| Loss of Function of SMAD4 in Cancer | R-HSA-3304347 | 2.976048e-01 | 0.526 | 0 | 0 |
| TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | R-HSA-6791055 | 2.976048e-01 | 0.526 | 0 | 0 |
| Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) | R-HSA-5619050 | 2.976048e-01 | 0.526 | 0 | 0 |
| IKBKB deficiency causes SCID | R-HSA-5602636 | 2.976048e-01 | 0.526 | 0 | 0 |
| TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | R-HSA-6791462 | 2.976048e-01 | 0.526 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 1.155990e-01 | 0.937 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 1.155990e-01 | 0.937 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 1.155990e-01 | 0.937 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 1.155990e-01 | 0.937 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 1.155990e-01 | 0.937 | 0 | 0 |
| IRS activation | R-HSA-74713 | 1.999160e-01 | 0.699 | 0 | 0 |
| NFE2L2 regulating inflammation associated genes | R-HSA-9818026 | 1.999160e-01 | 0.699 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 1.417196e-01 | 0.849 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 1.417196e-01 | 0.849 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 1.417196e-01 | 0.849 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 1.032382e-01 | 0.986 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 1.032382e-01 | 0.986 | 0 | 0 |
| Differentiation of T cells | R-HSA-9945266 | 9.016661e-02 | 1.045 | 0 | 0 |
| Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | R-HSA-9942503 | 9.016661e-02 | 1.045 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 9.016661e-02 | 1.045 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 1.224592e-01 | 0.912 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 1.224592e-01 | 0.912 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 1.224592e-01 | 0.912 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 1.224592e-01 | 0.912 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 1.224592e-01 | 0.912 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 1.224592e-01 | 0.912 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 1.224592e-01 | 0.912 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 1.224592e-01 | 0.912 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 1.224592e-01 | 0.912 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 1.224592e-01 | 0.912 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 1.695762e-01 | 0.771 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 1.695762e-01 | 0.771 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 2.428877e-01 | 0.615 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 2.428877e-01 | 0.615 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 2.428877e-01 | 0.615 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 2.428877e-01 | 0.615 | 0 | 0 |
| PTK6 Regulates Cell Cycle | R-HSA-8849470 | 2.428877e-01 | 0.615 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 2.428877e-01 | 0.615 | 0 | 0 |
| Signaling by MAPK mutants | R-HSA-9652817 | 2.428877e-01 | 0.615 | 0 | 0 |
| TWIK related potassium channel (TREK) | R-HSA-1299503 | 3.756391e-01 | 0.425 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 3.756391e-01 | 0.425 | 0 | 0 |
| Mitotic Metaphase/Anaphase Transition | R-HSA-68881 | 3.756391e-01 | 0.425 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 3.756391e-01 | 0.425 | 0 | 0 |
| HHAT G278V doesn't palmitoylate Hh-Np | R-HSA-5658034 | 3.756391e-01 | 0.425 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 3.756391e-01 | 0.425 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 1.050583e-01 | 0.979 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 1.430727e-01 | 0.844 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 1.430727e-01 | 0.844 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 1.430727e-01 | 0.844 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 9.005884e-02 | 1.045 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 1.988364e-01 | 0.702 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 1.988364e-01 | 0.702 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 1.988364e-01 | 0.702 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 1.210762e-01 | 0.917 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 2.861890e-01 | 0.543 | 1 | 1 |
| RUNX1 regulates transcription of genes involved in WNT signaling | R-HSA-8939256 | 2.861890e-01 | 0.543 | 0 | 0 |
| Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | R-HSA-629587 | 2.861890e-01 | 0.543 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 2.861890e-01 | 0.543 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 8.769927e-02 | 1.057 | 0 | 0 |
| ChREBP activates metabolic gene expression | R-HSA-163765 | 2.291786e-01 | 0.640 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 2.291786e-01 | 0.640 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 2.291786e-01 | 0.640 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 2.291786e-01 | 0.640 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 2.291786e-01 | 0.640 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 2.291786e-01 | 0.640 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 2.291786e-01 | 0.640 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 9.887396e-02 | 1.005 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 9.887396e-02 | 1.005 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 9.887396e-02 | 1.005 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 1.879012e-01 | 0.726 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 1.107904e-01 | 0.955 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 1.107904e-01 | 0.955 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 1.464962e-01 | 0.834 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 1.752071e-01 | 0.756 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 1.752071e-01 | 0.756 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 1.752071e-01 | 0.756 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 2.118100e-01 | 0.674 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 2.602982e-01 | 0.585 | 0 | 0 |
| RUNX1 regulates estrogen receptor mediated transcription | R-HSA-8931987 | 3.292168e-01 | 0.483 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 3.292168e-01 | 0.483 | 0 | 0 |
| PP2A-mediated dephosphorylation of key metabolic factors | R-HSA-163767 | 3.292168e-01 | 0.483 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 3.292168e-01 | 0.483 | 0 | 0 |
| PTK6 Expression | R-HSA-8849473 | 3.292168e-01 | 0.483 | 0 | 0 |
| The NLRP1 inflammasome | R-HSA-844455 | 4.450080e-01 | 0.352 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 4.450080e-01 | 0.352 | 0 | 0 |
| Defective GCLC causes HAGGSD | R-HSA-5578999 | 4.450080e-01 | 0.352 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 4.450080e-01 | 0.352 | 0 | 0 |
| IRAK4 deficiency (TLR5) | R-HSA-5603037 | 4.450080e-01 | 0.352 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 9.835987e-02 | 1.007 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 1.367691e-01 | 0.864 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 1.082298e-01 | 0.966 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 1.082298e-01 | 0.966 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 1.082298e-01 | 0.966 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 1.507795e-01 | 0.822 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 2.919121e-01 | 0.535 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 2.919121e-01 | 0.535 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 1.397468e-01 | 0.855 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 1.104118e-01 | 0.957 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 1.104118e-01 | 0.957 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 1.104118e-01 | 0.957 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 2.155415e-01 | 0.666 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 1.970645e-01 | 0.705 | 0 | 0 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | R-HSA-77588 | 3.714978e-01 | 0.430 | 0 | 0 |
| Activation of RAS in B cells | R-HSA-1169092 | 3.714978e-01 | 0.430 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 1.806807e-01 | 0.743 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 2.367109e-01 | 0.626 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 2.367109e-01 | 0.626 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 9.629421e-02 | 1.016 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 1.119323e-01 | 0.951 | 0 | 0 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | R-HSA-9661069 | 3.237608e-01 | 0.490 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 1.038475e-01 | 0.984 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 1.303770e-01 | 0.885 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 2.876410e-01 | 0.541 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 2.876410e-01 | 0.541 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 1.036231e-01 | 0.985 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 2.338971e-01 | 0.631 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 2.338971e-01 | 0.631 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 2.338971e-01 | 0.631 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 1.199875e-01 | 0.921 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 2.128316e-01 | 0.672 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 2.128316e-01 | 0.672 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 1.944487e-01 | 0.711 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 8.883208e-02 | 1.051 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 1.391414e-01 | 0.857 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 1.391414e-01 | 0.857 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 1.189601e-01 | 0.925 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 2.530622e-01 | 0.597 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 3.137807e-01 | 0.503 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 3.137807e-01 | 0.503 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 3.137807e-01 | 0.503 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 3.556107e-01 | 0.449 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 4.126670e-01 | 0.384 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 4.126670e-01 | 0.384 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 5.066734e-01 | 0.295 | 0 | 0 |
| HCN channels | R-HSA-1296061 | 5.066734e-01 | 0.295 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 5.066734e-01 | 0.295 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 5.066734e-01 | 0.295 | 0 | 0 |
| Defective LFNG causes SCDO3 | R-HSA-5083630 | 5.066734e-01 | 0.295 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 5.066734e-01 | 0.295 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 2.246757e-01 | 0.648 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 2.468861e-01 | 0.608 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 2.726394e-01 | 0.564 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 1.311206e-01 | 0.882 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 2.925623e-01 | 0.534 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 3.872537e-01 | 0.412 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 3.872537e-01 | 0.412 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 3.872537e-01 | 0.412 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 3.665085e-01 | 0.436 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 4.524499e-01 | 0.344 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 4.524499e-01 | 0.344 | 0 | 0 |
| Activation of Ca-permeable Kainate Receptor | R-HSA-451308 | 4.524499e-01 | 0.344 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 3.487805e-01 | 0.457 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 2.200278e-01 | 0.658 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 2.895382e-01 | 0.538 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 2.895382e-01 | 0.538 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 1.864474e-01 | 0.729 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 2.791288e-01 | 0.554 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 3.331820e-01 | 0.477 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 3.928436e-01 | 0.406 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 2.947549e-01 | 0.531 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 3.717945e-01 | 0.430 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 3.717945e-01 | 0.430 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 3.537498e-01 | 0.451 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 3.537498e-01 | 0.451 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 3.378498e-01 | 0.471 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 3.016145e-01 | 0.521 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 4.190067e-01 | 0.378 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 4.492144e-01 | 0.348 | 0 | 0 |
| Phase 2 - plateau phase | R-HSA-5576893 | 4.492144e-01 | 0.348 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 4.906463e-01 | 0.309 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in interleukin signaling | R-HSA-8939247 | 5.614903e-01 | 0.251 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in BCR signaling | R-HSA-8939245 | 5.614903e-01 | 0.251 | 0 | 0 |
| PTK6 Down-Regulation | R-HSA-8849472 | 5.614903e-01 | 0.251 | 0 | 0 |
| NOSIP mediated eNOS trafficking | R-HSA-203754 | 5.614903e-01 | 0.251 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 5.614903e-01 | 0.251 | 0 | 0 |
| Defective F9 activation | R-HSA-9673221 | 5.614903e-01 | 0.251 | 0 | 0 |
| Enhanced binding of GP1BA variant to VWF multimer:collagen | R-HSA-9845620 | 5.614903e-01 | 0.251 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 5.614903e-01 | 0.251 | 0 | 0 |
| Defective SLC1A3 causes episodic ataxia 6 (EA6) | R-HSA-5619062 | 5.614903e-01 | 0.251 | 0 | 0 |
| Defective binding of VWF variant to GPIb:IX:V | R-HSA-9846298 | 5.614903e-01 | 0.251 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 3.755413e-01 | 0.425 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 4.792403e-01 | 0.319 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 4.792403e-01 | 0.319 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 4.405300e-01 | 0.356 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 3.579300e-01 | 0.446 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 3.304681e-01 | 0.481 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 4.704191e-01 | 0.328 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 5.271178e-01 | 0.278 | 0 | 0 |
| Presynaptic nicotinic acetylcholine receptors | R-HSA-622323 | 5.271178e-01 | 0.278 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 5.271178e-01 | 0.278 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 5.271178e-01 | 0.278 | 0 | 0 |
| ERKs are inactivated | R-HSA-202670 | 5.271178e-01 | 0.278 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 5.084732e-01 | 0.294 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 5.084732e-01 | 0.294 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 4.511088e-01 | 0.346 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 4.954948e-01 | 0.305 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 4.116395e-01 | 0.385 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 4.770118e-01 | 0.321 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 4.432886e-01 | 0.353 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 4.678060e-01 | 0.330 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 4.807097e-01 | 0.318 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 5.200513e-01 | 0.284 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 5.368214e-01 | 0.270 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 5.368214e-01 | 0.270 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 5.617762e-01 | 0.250 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 5.617762e-01 | 0.250 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 5.617762e-01 | 0.250 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 5.167957e-01 | 0.287 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 5.167957e-01 | 0.287 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 5.167957e-01 | 0.287 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 5.167957e-01 | 0.287 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 5.167957e-01 | 0.287 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 5.440264e-01 | 0.264 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 4.931349e-01 | 0.307 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 4.931349e-01 | 0.307 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 5.642120e-01 | 0.249 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 5.642120e-01 | 0.249 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 5.642120e-01 | 0.249 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 5.642120e-01 | 0.249 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 5.425902e-01 | 0.266 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 5.553539e-01 | 0.255 | 0 | 0 |
| RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | R-HSA-8877330 | 5.945741e-01 | 0.226 | 0 | 0 |
| Acetylcholine binding and downstream events | R-HSA-181431 | 5.945741e-01 | 0.226 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 5.945741e-01 | 0.226 | 0 | 0 |
| Postsynaptic nicotinic acetylcholine receptors | R-HSA-622327 | 5.945741e-01 | 0.226 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 5.496079e-01 | 0.260 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 5.686861e-01 | 0.245 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 5.905891e-01 | 0.229 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 5.704769e-01 | 0.244 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 5.900303e-01 | 0.229 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 5.900303e-01 | 0.229 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 5.926674e-01 | 0.227 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 5.924250e-01 | 0.227 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 2.958051e-01 | 0.529 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 3.839326e-01 | 0.416 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 6.008367e-01 | 0.221 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 2.468861e-01 | 0.608 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 5.289127e-01 | 0.277 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 1.186337e-01 | 0.926 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 2.895382e-01 | 0.538 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 4.523633e-01 | 0.345 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 4.523633e-01 | 0.345 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 1.752071e-01 | 0.756 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 4.177442e-01 | 0.379 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 1.311166e-01 | 0.882 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 2.093488e-01 | 0.679 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 5.945741e-01 | 0.226 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 5.908854e-01 | 0.228 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 2.839159e-01 | 0.547 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 9.544653e-02 | 1.020 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 1.699676e-01 | 0.770 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 1.126255e-01 | 0.948 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 5.707208e-01 | 0.244 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 4.821403e-01 | 0.317 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 1.752071e-01 | 0.756 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 3.717945e-01 | 0.430 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 5.425902e-01 | 0.266 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 1.648332e-01 | 0.783 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 1.381569e-01 | 0.860 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 4.235938e-01 | 0.373 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 4.821403e-01 | 0.317 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 4.821403e-01 | 0.317 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 1.695762e-01 | 0.771 | 0 | 0 |
| Transcriptional regulation of testis differentiation | R-HSA-9690406 | 2.365063e-01 | 0.626 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 5.617762e-01 | 0.250 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 5.673675e-01 | 0.246 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 1.036098e-01 | 0.985 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 2.147419e-01 | 0.668 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 2.273317e-01 | 0.643 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 9.887396e-02 | 1.005 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 8.955046e-02 | 1.048 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 1.383022e-01 | 0.859 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 3.744060e-01 | 0.427 | 0 | 0 |
| PTK6 Regulates Proteins Involved in RNA Processing | R-HSA-8849468 | 5.614903e-01 | 0.251 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 5.642120e-01 | 0.249 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 4.576377e-01 | 0.339 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 4.576377e-01 | 0.339 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 3.237608e-01 | 0.490 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 3.872537e-01 | 0.412 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 2.390502e-01 | 0.622 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 1.464962e-01 | 0.834 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 1.295614e-01 | 0.888 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 4.126670e-01 | 0.384 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 5.167957e-01 | 0.287 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 2.365063e-01 | 0.626 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 1.654288e-01 | 0.781 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 5.553539e-01 | 0.255 | 0 | 0 |
| Nef Mediated CD4 Down-regulation | R-HSA-167590 | 3.292168e-01 | 0.483 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 4.126670e-01 | 0.384 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 9.746185e-02 | 1.011 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 4.524499e-01 | 0.344 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 4.524499e-01 | 0.344 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 4.185075e-01 | 0.378 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 3.537498e-01 | 0.451 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 4.190067e-01 | 0.378 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 4.363194e-01 | 0.360 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 5.897905e-01 | 0.229 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 1.403997e-01 | 0.853 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 5.220945e-01 | 0.282 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 5.362457e-01 | 0.271 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 2.530622e-01 | 0.597 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 5.084732e-01 | 0.294 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 5.806362e-01 | 0.236 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 1.104118e-01 | 0.957 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 1.104118e-01 | 0.957 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 1.989796e-01 | 0.701 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 5.066436e-01 | 0.295 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 3.928436e-01 | 0.406 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 5.073432e-01 | 0.295 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 5.924250e-01 | 0.227 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 1.149403e-01 | 0.940 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 1.101999e-01 | 0.958 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 5.440264e-01 | 0.264 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 5.659213e-01 | 0.247 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 1.580318e-01 | 0.801 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of cell cycle factors | R-HSA-8866911 | 1.580318e-01 | 0.801 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 1.417196e-01 | 0.849 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 1.695762e-01 | 0.771 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 2.919121e-01 | 0.535 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 3.714978e-01 | 0.430 | 0 | 0 |
| Nef mediated downregulation of MHC class I complex cell surface expression | R-HSA-164940 | 3.714978e-01 | 0.430 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 1.944487e-01 | 0.711 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 5.066734e-01 | 0.295 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 3.030837e-01 | 0.518 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 1.363794e-01 | 0.865 | 0 | 0 |
| Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | R-HSA-9931529 | 5.614903e-01 | 0.251 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 4.448958e-01 | 0.352 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 5.271178e-01 | 0.278 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 4.368623e-01 | 0.360 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 4.853883e-01 | 0.314 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 5.645688e-01 | 0.248 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 5.054762e-01 | 0.296 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 5.269836e-01 | 0.278 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 1.170575e-01 | 0.932 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 1.661887e-01 | 0.779 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 3.127649e-01 | 0.505 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 2.927353e-01 | 0.534 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 5.924250e-01 | 0.227 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 5.837783e-01 | 0.234 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 4.576377e-01 | 0.339 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 1.349072e-01 | 0.870 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 1.795245e-01 | 0.746 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 5.659213e-01 | 0.247 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 2.145475e-01 | 0.668 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 2.145475e-01 | 0.668 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 3.710671e-01 | 0.431 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 5.619517e-01 | 0.250 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 1.988364e-01 | 0.702 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 1.295614e-01 | 0.888 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 3.301066e-01 | 0.481 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 4.327387e-01 | 0.364 | 0 | 0 |
| Activated NTRK2 signals through FRS2 and FRS3 | R-HSA-9028731 | 5.617762e-01 | 0.250 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 5.289127e-01 | 0.277 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 3.827490e-01 | 0.417 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 1.067878e-01 | 0.971 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 1.804046e-01 | 0.744 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 4.032061e-01 | 0.394 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 4.109170e-01 | 0.386 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 1.408953e-01 | 0.851 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 2.925623e-01 | 0.534 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 4.185075e-01 | 0.378 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 2.728634e-01 | 0.564 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 3.956752e-01 | 0.403 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 5.659936e-01 | 0.247 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 2.073360e-01 | 0.683 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 2.016841e-01 | 0.695 | 0 | 0 |
| S Phase | R-HSA-69242 | 4.003639e-01 | 0.398 | 0 | 0 |
| Ca2+ activated K+ channels | R-HSA-1296052 | 1.155990e-01 | 0.937 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 1.695762e-01 | 0.771 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 2.428877e-01 | 0.615 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 2.618340e-01 | 0.582 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 1.964957e-01 | 0.707 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 4.524499e-01 | 0.344 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 2.895382e-01 | 0.538 | 0 | 0 |
| Formation of the posterior neural plate | R-HSA-9832991 | 4.906463e-01 | 0.309 | 0 | 0 |
| Resolution of AP sites via the single-nucleotide replacement pathway | R-HSA-110381 | 5.614903e-01 | 0.251 | 0 | 0 |
| Post-transcriptional silencing by small RNAs | R-HSA-426496 | 5.614903e-01 | 0.251 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 4.792403e-01 | 0.319 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 5.271178e-01 | 0.278 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 4.853883e-01 | 0.314 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 4.621889e-01 | 0.335 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 2.067376e-01 | 0.685 | 1 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 5.262534e-01 | 0.279 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 5.741688e-01 | 0.241 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 3.316862e-01 | 0.479 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 3.717945e-01 | 0.430 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 3.948082e-01 | 0.404 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 5.289127e-01 | 0.277 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 3.944763e-01 | 0.404 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 1.435359e-01 | 0.843 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 3.737552e-01 | 0.427 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 5.066436e-01 | 0.295 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 5.066436e-01 | 0.295 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 5.601755e-01 | 0.252 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 1.381569e-01 | 0.860 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 1.165578e-01 | 0.933 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 2.602982e-01 | 0.585 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 2.919121e-01 | 0.535 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 1.383411e-01 | 0.859 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 3.499538e-01 | 0.456 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 2.623734e-01 | 0.581 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 2.244895e-01 | 0.649 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 1.562275e-01 | 0.806 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 2.296439e-01 | 0.639 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 1.580318e-01 | 0.801 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 1.806807e-01 | 0.743 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 1.637720e-01 | 0.786 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 3.872537e-01 | 0.412 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 2.273317e-01 | 0.643 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 4.524499e-01 | 0.344 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 4.524499e-01 | 0.344 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 4.157468e-01 | 0.381 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 4.853883e-01 | 0.314 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 5.200513e-01 | 0.284 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 3.976932e-01 | 0.400 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 1.961162e-01 | 0.707 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 5.533057e-01 | 0.257 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 4.853883e-01 | 0.314 | 0 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 9.154840e-02 | 1.038 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 1.032382e-01 | 0.986 | 0 | 0 |
| Nitric oxide stimulates guanylate cyclase | R-HSA-392154 | 2.338971e-01 | 0.631 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 4.970385e-01 | 0.304 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 5.900303e-01 | 0.229 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 4.193092e-01 | 0.377 | 1 | 0 |
| Deubiquitination | R-HSA-5688426 | 3.444505e-01 | 0.463 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 4.144843e-01 | 0.382 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 3.292168e-01 | 0.483 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 1.038475e-01 | 0.984 | 0 | 0 |
| PTK6 Activates STAT3 | R-HSA-8849474 | 5.614903e-01 | 0.251 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 4.853883e-01 | 0.314 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 5.368214e-01 | 0.270 | 1 | 1 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 4.448958e-01 | 0.352 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 2.805772e-01 | 0.552 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 2.805772e-01 | 0.552 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 3.872537e-01 | 0.412 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 1.369757e-01 | 0.863 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 2.154913e-01 | 0.667 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 1.010777e-01 | 0.995 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 2.390502e-01 | 0.622 | 1 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 4.704191e-01 | 0.328 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 1.304148e-01 | 0.885 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 2.944877e-01 | 0.531 | 1 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 2.779320e-01 | 0.556 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 2.152096e-01 | 0.667 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 3.127649e-01 | 0.505 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 1.482077e-01 | 0.829 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 1.936869e-01 | 0.713 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 5.368214e-01 | 0.270 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 5.874162e-01 | 0.231 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 5.521357e-01 | 0.258 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 3.471370e-01 | 0.459 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 2.223930e-01 | 0.653 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 4.630986e-01 | 0.334 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 2.586181e-01 | 0.587 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 5.872889e-01 | 0.231 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 4.951777e-01 | 0.305 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 4.951777e-01 | 0.305 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 3.983345e-01 | 0.400 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 1.155990e-01 | 0.937 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 9.016661e-02 | 1.045 | 0 | 0 |
| Acetylcholine inhibits contraction of outer hair cells | R-HSA-9667769 | 2.428877e-01 | 0.615 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 1.649369e-01 | 0.783 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 2.602982e-01 | 0.585 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 2.602982e-01 | 0.585 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 4.450080e-01 | 0.352 | 0 | 0 |
| Activation of BIM and translocation to mitochondria | R-HSA-111446 | 4.450080e-01 | 0.352 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 2.365063e-01 | 0.626 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 2.919121e-01 | 0.535 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 1.970645e-01 | 0.705 | 0 | 0 |
| Co-stimulation by ICOS | R-HSA-9927354 | 3.714978e-01 | 0.430 | 0 | 0 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | R-HSA-9659787 | 3.237608e-01 | 0.490 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 2.876410e-01 | 0.541 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 2.876410e-01 | 0.541 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 2.338971e-01 | 0.631 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 1.782214e-01 | 0.749 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 4.524499e-01 | 0.344 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 3.487805e-01 | 0.457 | 0 | 0 |
| Phase 4 - resting membrane potential | R-HSA-5576886 | 4.185075e-01 | 0.378 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 2.986636e-01 | 0.525 | 0 | 0 |
| Ionotropic activity of kainate receptors | R-HSA-451306 | 4.906463e-01 | 0.309 | 0 | 0 |
| Trafficking of myristoylated proteins to the cilium | R-HSA-5624138 | 5.614903e-01 | 0.251 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 5.614903e-01 | 0.251 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 5.614903e-01 | 0.251 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 2.497839e-01 | 0.602 | 1 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 3.443263e-01 | 0.463 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 4.704191e-01 | 0.328 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 4.954948e-01 | 0.305 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 4.883152e-01 | 0.311 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 5.642120e-01 | 0.249 | 0 | 0 |
| Kinesins | R-HSA-983189 | 5.482374e-01 | 0.261 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 5.945741e-01 | 0.226 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 5.908854e-01 | 0.228 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 2.016539e-01 | 0.695 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 2.344748e-01 | 0.630 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 2.127555e-01 | 0.672 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 2.468861e-01 | 0.608 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 2.584042e-01 | 0.588 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 3.191869e-01 | 0.496 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 5.200513e-01 | 0.284 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 1.782214e-01 | 0.749 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 1.186337e-01 | 0.926 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 2.093488e-01 | 0.679 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 2.315988e-01 | 0.635 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 1.806807e-01 | 0.743 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 1.399542e-01 | 0.854 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 1.660043e-01 | 0.780 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 1.297031e-01 | 0.887 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 2.728634e-01 | 0.564 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 3.127649e-01 | 0.505 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 3.127649e-01 | 0.505 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 3.331820e-01 | 0.477 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 4.807097e-01 | 0.318 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 1.250508e-01 | 0.903 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 4.739361e-01 | 0.324 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 1.879012e-01 | 0.726 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 9.409905e-02 | 1.026 | 1 | 1 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 1.119323e-01 | 0.951 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 3.030837e-01 | 0.518 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 1.915478e-01 | 0.718 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 2.564696e-01 | 0.591 | 0 | 0 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 4.492144e-01 | 0.348 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 4.522631e-01 | 0.345 | 1 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 1.626495e-01 | 0.789 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 5.188363e-01 | 0.285 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 1.190050e-01 | 0.924 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 2.876410e-01 | 0.541 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 3.192448e-01 | 0.496 | 0 | 0 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | R-HSA-5676594 | 5.945741e-01 | 0.226 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 3.177033e-01 | 0.498 | 1 | 0 |
| MAP kinase activation | R-HSA-450294 | 5.645688e-01 | 0.248 | 1 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 5.161454e-01 | 0.287 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 2.428877e-01 | 0.615 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 1.430727e-01 | 0.844 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 3.292168e-01 | 0.483 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 3.714978e-01 | 0.430 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 4.126670e-01 | 0.384 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 3.401135e-01 | 0.468 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 3.872537e-01 | 0.412 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 2.839159e-01 | 0.547 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 4.190067e-01 | 0.378 | 0 | 0 |
| Muscarinic acetylcholine receptors | R-HSA-390648 | 5.614903e-01 | 0.251 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 4.448958e-01 | 0.352 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 4.863530e-01 | 0.313 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 5.945741e-01 | 0.226 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 3.136016e-01 | 0.504 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 5.401037e-01 | 0.268 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 4.524499e-01 | 0.344 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 2.738124e-01 | 0.563 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 1.403997e-01 | 0.853 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 4.126670e-01 | 0.384 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 5.200513e-01 | 0.284 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 5.945741e-01 | 0.226 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 5.945741e-01 | 0.226 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 5.900303e-01 | 0.229 | 1 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 4.365649e-01 | 0.360 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 1.381569e-01 | 0.860 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 2.986636e-01 | 0.525 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 4.738600e-01 | 0.324 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 4.792403e-01 | 0.319 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 2.976048e-01 | 0.526 | 0 | 0 |
| DSCAM interactions | R-HSA-376172 | 3.756391e-01 | 0.425 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 2.291786e-01 | 0.640 | 0 | 0 |
| Formation of the anterior neural plate | R-HSA-9823739 | 1.879012e-01 | 0.726 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 1.234300e-01 | 0.909 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 2.365063e-01 | 0.626 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 4.126670e-01 | 0.384 | 0 | 0 |
| Sensory perception of sour taste | R-HSA-9729555 | 5.066734e-01 | 0.295 | 0 | 0 |
| Tandem pore domain potassium channels | R-HSA-1296346 | 4.524499e-01 | 0.344 | 0 | 0 |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | 4.524499e-01 | 0.344 | 0 | 0 |
| Biosynthesis of DPAn-3-derived 13-series resolvins | R-HSA-9026403 | 5.614903e-01 | 0.251 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 3.944763e-01 | 0.404 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 4.754551e-01 | 0.323 | 0 | 0 |
| rRNA modification in the mitochondrion | R-HSA-6793080 | 5.945741e-01 | 0.226 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 5.905891e-01 | 0.229 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 3.560616e-01 | 0.448 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 4.523633e-01 | 0.345 | 1 | 1 |
| GPVI-mediated activation cascade | R-HSA-114604 | 5.707208e-01 | 0.244 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 1.171617e-01 | 0.931 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 3.137807e-01 | 0.503 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 4.177442e-01 | 0.379 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 5.440264e-01 | 0.264 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 1.238107e-01 | 0.907 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 4.768341e-01 | 0.322 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 5.245804e-01 | 0.280 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 1.508181e-01 | 0.822 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 1.695762e-01 | 0.771 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 5.672445e-01 | 0.246 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 1.171617e-01 | 0.931 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 1.988364e-01 | 0.702 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 2.861890e-01 | 0.543 | 0 | 0 |
| Histamine receptors | R-HSA-390650 | 4.450080e-01 | 0.352 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 1.367691e-01 | 0.864 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 3.127649e-01 | 0.505 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 3.136016e-01 | 0.504 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 1.642471e-01 | 0.785 | 1 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 1.050583e-01 | 0.979 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 3.872537e-01 | 0.412 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 5.601513e-01 | 0.252 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 1.015202e-01 | 0.993 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 2.428877e-01 | 0.615 | 0 | 0 |
| Phase 3 - rapid repolarisation | R-HSA-5576890 | 3.292168e-01 | 0.483 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 1.082298e-01 | 0.966 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 1.082298e-01 | 0.966 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 1.186337e-01 | 0.926 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 2.155415e-01 | 0.666 | 0 | 0 |
| Interleukin-18 signaling | R-HSA-9012546 | 3.714978e-01 | 0.430 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 4.126670e-01 | 0.384 | 0 | 0 |
| FLT3 signaling through SRC family kinases | R-HSA-9706374 | 5.066734e-01 | 0.295 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 3.928436e-01 | 0.406 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 4.906463e-01 | 0.309 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 4.853883e-01 | 0.314 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | R-HSA-9029558 | 5.945741e-01 | 0.226 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 2.971814e-01 | 0.527 | 1 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 4.185075e-01 | 0.378 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 1.626495e-01 | 0.789 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 5.642120e-01 | 0.249 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 5.725577e-01 | 0.242 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 2.982349e-01 | 0.525 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 1.649369e-01 | 0.783 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 3.556107e-01 | 0.449 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 3.665085e-01 | 0.436 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 4.157468e-01 | 0.381 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 4.190067e-01 | 0.378 | 0 | 0 |
| Depurination | R-HSA-73927 | 4.363194e-01 | 0.360 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 8.903110e-02 | 1.050 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 1.915305e-01 | 0.718 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 2.925623e-01 | 0.534 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 3.872537e-01 | 0.412 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperone genes | R-HSA-381183 | 5.271178e-01 | 0.278 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 5.945741e-01 | 0.226 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 4.931349e-01 | 0.307 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 3.918904e-01 | 0.407 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 2.876410e-01 | 0.541 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 3.665085e-01 | 0.436 | 0 | 0 |
| Nephron development | R-HSA-9831926 | 5.084732e-01 | 0.294 | 0 | 0 |
| Interleukin-15 signaling | R-HSA-8983432 | 5.617762e-01 | 0.250 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 9.835987e-02 | 1.007 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 2.468714e-01 | 0.608 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 4.576377e-01 | 0.339 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 5.943247e-01 | 0.226 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 3.755413e-01 | 0.425 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 3.755413e-01 | 0.425 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 2.128316e-01 | 0.672 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 5.368214e-01 | 0.270 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 5.617762e-01 | 0.250 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 5.945741e-01 | 0.226 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 4.032061e-01 | 0.394 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 4.524499e-01 | 0.344 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 4.704191e-01 | 0.328 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 3.313944e-01 | 0.480 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperones | R-HSA-381033 | 5.945741e-01 | 0.226 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 5.762233e-01 | 0.239 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 6.054422e-01 | 0.218 | 0 | 0 |
| Nef Mediated CD8 Down-regulation | R-HSA-182218 | 6.102190e-01 | 0.215 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 6.102190e-01 | 0.215 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 6.102190e-01 | 0.215 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 6.102190e-01 | 0.215 | 0 | 0 |
| Defective CSF2RB causes SMDP5 | R-HSA-5688849 | 6.102190e-01 | 0.215 | 0 | 0 |
| Signaling by RNF43 mutants | R-HSA-5340588 | 6.102190e-01 | 0.215 | 0 | 0 |
| Defective CSF2RA causes SMDP4 | R-HSA-5688890 | 6.102190e-01 | 0.215 | 0 | 0 |
| Ligand-receptor interactions | R-HSA-5632681 | 6.102190e-01 | 0.215 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 6.102190e-01 | 0.215 | 0 | 0 |
| Pentose phosphate pathway disease | R-HSA-6791465 | 6.102190e-01 | 0.215 | 0 | 0 |
| NGF-independant TRKA activation | R-HSA-187024 | 6.102190e-01 | 0.215 | 0 | 0 |
| Synthesis of PS | R-HSA-1483101 | 6.102190e-01 | 0.215 | 0 | 0 |
| Formation of the Editosome | R-HSA-75094 | 6.102190e-01 | 0.215 | 0 | 0 |
| CDC6 association with the ORC:origin complex | R-HSA-68689 | 6.102190e-01 | 0.215 | 0 | 0 |
| Release of Hh-Np from the secreting cell | R-HSA-5362798 | 6.102190e-01 | 0.215 | 0 | 0 |
| Defects of platelet adhesion to exposed collagen | R-HSA-9823587 | 6.102190e-01 | 0.215 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 6.102190e-01 | 0.215 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 6.102190e-01 | 0.215 | 0 | 0 |
| SLC15A4:TASL-dependent IRF5 activation | R-HSA-9860276 | 6.102190e-01 | 0.215 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 6.103363e-01 | 0.214 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 6.103363e-01 | 0.214 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 6.103363e-01 | 0.214 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 6.103363e-01 | 0.214 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 6.103363e-01 | 0.214 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 6.103363e-01 | 0.214 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 6.119059e-01 | 0.213 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 6.119790e-01 | 0.213 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 6.119790e-01 | 0.213 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 6.119790e-01 | 0.213 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 6.132076e-01 | 0.212 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 6.132076e-01 | 0.212 | 0 | 0 |
| FRS-mediated FGFR3 signaling | R-HSA-5654706 | 6.159117e-01 | 0.210 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 6.159117e-01 | 0.210 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 6.159117e-01 | 0.210 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 6.159117e-01 | 0.210 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 6.180271e-01 | 0.209 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 6.208421e-01 | 0.207 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 6.208421e-01 | 0.207 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 6.246498e-01 | 0.204 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 6.254969e-01 | 0.204 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 6.254969e-01 | 0.204 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 6.254969e-01 | 0.204 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 6.254969e-01 | 0.204 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 6.254969e-01 | 0.204 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 6.254969e-01 | 0.204 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 6.270761e-01 | 0.203 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 6.275170e-01 | 0.202 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 6.275170e-01 | 0.202 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 6.282768e-01 | 0.202 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 6.285694e-01 | 0.202 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 6.292630e-01 | 0.201 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 6.295883e-01 | 0.201 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 6.316832e-01 | 0.200 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 6.331854e-01 | 0.198 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 6.355137e-01 | 0.197 | 1 | 0 |
| FRS-mediated FGFR4 signaling | R-HSA-5654712 | 6.401528e-01 | 0.194 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 6.401528e-01 | 0.194 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 6.401528e-01 | 0.194 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 6.429116e-01 | 0.192 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 6.442752e-01 | 0.191 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 6.448059e-01 | 0.191 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 6.480821e-01 | 0.188 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 6.480821e-01 | 0.188 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 6.480821e-01 | 0.188 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 6.480821e-01 | 0.188 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 6.480821e-01 | 0.188 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 6.480821e-01 | 0.188 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 6.480821e-01 | 0.188 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 6.535354e-01 | 0.185 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 6.535354e-01 | 0.185 | 0 | 0 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 6.535354e-01 | 0.185 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 6.535354e-01 | 0.185 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 6.535354e-01 | 0.185 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 6.535354e-01 | 0.185 | 0 | 0 |
| Neurofascin interactions | R-HSA-447043 | 6.535354e-01 | 0.185 | 0 | 0 |
| Abacavir transmembrane transport | R-HSA-2161517 | 6.535354e-01 | 0.185 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 6.535354e-01 | 0.185 | 0 | 0 |
| NADPH regeneration | R-HSA-389542 | 6.535354e-01 | 0.185 | 0 | 0 |
| Lipid particle organization | R-HSA-8964572 | 6.535354e-01 | 0.185 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 6.535354e-01 | 0.185 | 0 | 0 |
| Leukotriene receptors | R-HSA-391906 | 6.535354e-01 | 0.185 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 6.544541e-01 | 0.184 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 6.545564e-01 | 0.184 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 6.545564e-01 | 0.184 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 6.545564e-01 | 0.184 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 6.545564e-01 | 0.184 | 0 | 0 |
| RNA Polymerase III Chain Elongation | R-HSA-73780 | 6.545564e-01 | 0.184 | 0 | 0 |
| Telomere C-strand synthesis initiation | R-HSA-174430 | 6.545564e-01 | 0.184 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 6.545564e-01 | 0.184 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 6.545564e-01 | 0.184 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 6.548929e-01 | 0.184 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 6.555615e-01 | 0.183 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 6.576910e-01 | 0.182 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 6.583302e-01 | 0.182 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 6.632969e-01 | 0.178 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 6.632969e-01 | 0.178 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.683427e-01 | 0.175 | 1 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 6.695589e-01 | 0.174 | 1 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 6.732931e-01 | 0.172 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 6.733399e-01 | 0.172 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 6.758220e-01 | 0.170 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 6.772908e-01 | 0.169 | 1 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 6.772908e-01 | 0.169 | 1 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 6.773683e-01 | 0.169 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 6.773683e-01 | 0.169 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 6.799540e-01 | 0.168 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 6.817848e-01 | 0.166 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 6.817848e-01 | 0.166 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 6.817848e-01 | 0.166 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 6.817848e-01 | 0.166 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 6.817848e-01 | 0.166 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 6.817848e-01 | 0.166 | 0 | 0 |
| Serotonin and melatonin biosynthesis | R-HSA-209931 | 6.817848e-01 | 0.166 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 6.817848e-01 | 0.166 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 6.817848e-01 | 0.166 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 6.832754e-01 | 0.165 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 6.836360e-01 | 0.165 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 6.836360e-01 | 0.165 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 6.853391e-01 | 0.164 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 6.853391e-01 | 0.164 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 6.853391e-01 | 0.164 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 6.879317e-01 | 0.162 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 6.879317e-01 | 0.162 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 6.879317e-01 | 0.162 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 6.879317e-01 | 0.162 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 6.879317e-01 | 0.162 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 6.903948e-01 | 0.161 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 6.920402e-01 | 0.160 | 0 | 0 |
| Defective HLCS causes multiple carboxylase deficiency | R-HSA-3371599 | 6.920402e-01 | 0.160 | 0 | 0 |
| NOSTRIN mediated eNOS trafficking | R-HSA-203641 | 6.920402e-01 | 0.160 | 0 | 0 |
| Netrin mediated repulsion signals | R-HSA-418886 | 6.920402e-01 | 0.160 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 6.920402e-01 | 0.160 | 0 | 0 |
| Pre-NOTCH Processing in the Endoplasmic Reticulum | R-HSA-1912399 | 6.920402e-01 | 0.160 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 6.920402e-01 | 0.160 | 0 | 0 |
| SLBP independent Processing of Histone Pre-mRNAs | R-HSA-111367 | 6.920402e-01 | 0.160 | 0 | 0 |
| mRNA Editing: C to U Conversion | R-HSA-72200 | 6.920402e-01 | 0.160 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 6.920402e-01 | 0.160 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 6.920402e-01 | 0.160 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 6.920402e-01 | 0.160 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 6.920402e-01 | 0.160 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 6.920402e-01 | 0.160 | 0 | 0 |
| Activation of TRKA receptors | R-HSA-187015 | 6.920402e-01 | 0.160 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 6.920402e-01 | 0.160 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 6.920402e-01 | 0.160 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 6.921709e-01 | 0.160 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 6.921709e-01 | 0.160 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 6.921709e-01 | 0.160 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 6.921709e-01 | 0.160 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 6.963764e-01 | 0.157 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 6.977894e-01 | 0.156 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 6.977894e-01 | 0.156 | 1 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 6.999551e-01 | 0.155 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 7.018583e-01 | 0.154 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 7.020984e-01 | 0.154 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 7.041094e-01 | 0.152 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 7.062836e-01 | 0.151 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 7.062836e-01 | 0.151 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 7.062836e-01 | 0.151 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 7.062836e-01 | 0.151 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 7.062836e-01 | 0.151 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 7.070358e-01 | 0.151 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 7.072301e-01 | 0.150 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 7.072301e-01 | 0.150 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 7.072301e-01 | 0.150 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 7.072301e-01 | 0.150 | 0 | 0 |
| Passive transport by Aquaporins | R-HSA-432047 | 7.072301e-01 | 0.150 | 0 | 0 |
| Synthesis of PG | R-HSA-1483148 | 7.072301e-01 | 0.150 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 7.102583e-01 | 0.149 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 7.102583e-01 | 0.149 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 7.108442e-01 | 0.148 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 7.130557e-01 | 0.147 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 7.135044e-01 | 0.147 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 7.191636e-01 | 0.143 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 7.214909e-01 | 0.142 | 1 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 7.224629e-01 | 0.141 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 7.235231e-01 | 0.141 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 7.261420e-01 | 0.139 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 7.261420e-01 | 0.139 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 7.261420e-01 | 0.139 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 7.262678e-01 | 0.139 | 0 | 0 |
| FGFR1b ligand binding and activation | R-HSA-190370 | 7.262678e-01 | 0.139 | 0 | 0 |
| Highly calcium permeable nicotinic acetylcholine receptors | R-HSA-629597 | 7.262678e-01 | 0.139 | 0 | 0 |
| Regulation of NPAS4 mRNA translation | R-HSA-9768778 | 7.262678e-01 | 0.139 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of keratinocytes | R-HSA-8939242 | 7.262678e-01 | 0.139 | 0 | 0 |
| Axonal growth inhibition (RHOA activation) | R-HSA-193634 | 7.262678e-01 | 0.139 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 7.262678e-01 | 0.139 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 7.262678e-01 | 0.139 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 7.262678e-01 | 0.139 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 7.262678e-01 | 0.139 | 0 | 0 |
| Neurotransmitter uptake and metabolism In glial cells | R-HSA-112313 | 7.262678e-01 | 0.139 | 0 | 0 |
| Astrocytic Glutamate-Glutamine Uptake And Metabolism | R-HSA-210455 | 7.262678e-01 | 0.139 | 0 | 0 |
| Activated NTRK2 signals through FYN | R-HSA-9032500 | 7.262678e-01 | 0.139 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 7.275566e-01 | 0.138 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 7.301108e-01 | 0.137 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 7.309523e-01 | 0.136 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 7.309523e-01 | 0.136 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 7.309523e-01 | 0.136 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 7.309523e-01 | 0.136 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 7.314575e-01 | 0.136 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 7.314575e-01 | 0.136 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 7.314575e-01 | 0.136 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 7.346386e-01 | 0.134 | 1 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 7.346386e-01 | 0.134 | 1 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 7.346386e-01 | 0.134 | 1 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 7.364752e-01 | 0.133 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 7.365737e-01 | 0.133 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 7.392297e-01 | 0.131 | 1 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 7.418524e-01 | 0.130 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 7.420038e-01 | 0.130 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 7.440712e-01 | 0.128 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 7.442719e-01 | 0.128 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 7.449327e-01 | 0.128 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 7.449327e-01 | 0.128 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 7.449327e-01 | 0.128 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 7.449327e-01 | 0.128 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 7.459936e-01 | 0.127 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 7.487202e-01 | 0.126 | 1 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 7.516553e-01 | 0.124 | 1 | 0 |
| Tie2 Signaling | R-HSA-210993 | 7.530200e-01 | 0.123 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 7.530200e-01 | 0.123 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 7.530200e-01 | 0.123 | 0 | 0 |
| Interleukin-21 signaling | R-HSA-9020958 | 7.566930e-01 | 0.121 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 7.566930e-01 | 0.121 | 0 | 0 |
| Defects in biotin (Btn) metabolism | R-HSA-3323169 | 7.566930e-01 | 0.121 | 0 | 0 |
| APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | R-HSA-5649702 | 7.566930e-01 | 0.121 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 7.566930e-01 | 0.121 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 7.566930e-01 | 0.121 | 0 | 0 |
| p75NTR regulates axonogenesis | R-HSA-193697 | 7.566930e-01 | 0.121 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 7.566930e-01 | 0.121 | 0 | 0 |
| mRNA Editing | R-HSA-75072 | 7.566930e-01 | 0.121 | 0 | 0 |
| Regulation of NPAS4 gene transcription | R-HSA-9768777 | 7.566930e-01 | 0.121 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 7.566930e-01 | 0.121 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 7.566930e-01 | 0.121 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 7.566930e-01 | 0.121 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 7.566930e-01 | 0.121 | 0 | 0 |
| Butyrophilin (BTN) family interactions | R-HSA-8851680 | 7.566930e-01 | 0.121 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 7.577467e-01 | 0.120 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 7.592821e-01 | 0.120 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 7.598114e-01 | 0.119 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 7.612046e-01 | 0.118 | 1 | 0 |
| FRS-mediated FGFR2 signaling | R-HSA-5654700 | 7.626791e-01 | 0.118 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 7.626791e-01 | 0.118 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 7.626791e-01 | 0.118 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 7.626791e-01 | 0.118 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 7.626791e-01 | 0.118 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 7.629679e-01 | 0.117 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 7.629679e-01 | 0.117 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 7.643146e-01 | 0.117 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 7.649514e-01 | 0.116 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 7.649514e-01 | 0.116 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 7.657909e-01 | 0.116 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 7.693457e-01 | 0.114 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 7.717622e-01 | 0.113 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 7.730806e-01 | 0.112 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 7.735078e-01 | 0.112 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 7.735078e-01 | 0.112 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 7.740887e-01 | 0.111 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 7.740887e-01 | 0.111 | 1 | 1 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 7.740887e-01 | 0.111 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 7.740887e-01 | 0.111 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 7.747897e-01 | 0.111 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 7.747897e-01 | 0.111 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 7.747897e-01 | 0.111 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 7.794094e-01 | 0.108 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 7.794094e-01 | 0.108 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 7.794094e-01 | 0.108 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 7.794094e-01 | 0.108 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 7.812208e-01 | 0.107 | 0 | 0 |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | R-HSA-629594 | 7.837380e-01 | 0.106 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 7.837380e-01 | 0.106 | 0 | 0 |
| TET1,2,3 and TDG demethylate DNA | R-HSA-5221030 | 7.837380e-01 | 0.106 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 7.837380e-01 | 0.106 | 0 | 0 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | R-HSA-5140745 | 7.837380e-01 | 0.106 | 0 | 0 |
| Formation of intermediate mesoderm | R-HSA-9761174 | 7.837380e-01 | 0.106 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 7.837380e-01 | 0.106 | 0 | 0 |
| Receptor Mediated Mitophagy | R-HSA-8934903 | 7.837380e-01 | 0.106 | 0 | 0 |
| Maturation of spike protein | R-HSA-9683686 | 7.837380e-01 | 0.106 | 0 | 0 |
| Defective factor IX causes hemophilia B | R-HSA-9668250 | 7.837380e-01 | 0.106 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 7.837380e-01 | 0.106 | 0 | 0 |
| Sperm Motility And Taxes | R-HSA-1300642 | 7.837380e-01 | 0.106 | 0 | 0 |
| Metal sequestration by antimicrobial proteins | R-HSA-6799990 | 7.837380e-01 | 0.106 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 7.837763e-01 | 0.106 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 7.845006e-01 | 0.105 | 1 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 7.845006e-01 | 0.105 | 1 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 7.874392e-01 | 0.104 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 7.887517e-01 | 0.103 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 7.888404e-01 | 0.103 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 7.890211e-01 | 0.103 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 7.891240e-01 | 0.103 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 7.924943e-01 | 0.101 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 7.924943e-01 | 0.101 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 7.924943e-01 | 0.101 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 7.927748e-01 | 0.101 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 7.951551e-01 | 0.100 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 7.968627e-01 | 0.099 | 1 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 7.979687e-01 | 0.098 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 7.989306e-01 | 0.097 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 7.995002e-01 | 0.097 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 8.025233e-01 | 0.096 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 8.025233e-01 | 0.096 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 8.025233e-01 | 0.096 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 8.025233e-01 | 0.096 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 8.025233e-01 | 0.096 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 8.060357e-01 | 0.094 | 0 | 0 |
| Regulation of CDH11 mRNA translation by microRNAs | R-HSA-9759811 | 8.077782e-01 | 0.093 | 0 | 0 |
| FGFR2b ligand binding and activation | R-HSA-190377 | 8.077782e-01 | 0.093 | 0 | 0 |
| Activated NTRK3 signals through RAS | R-HSA-9034864 | 8.077782e-01 | 0.093 | 0 | 0 |
| FGFRL1 modulation of FGFR1 signaling | R-HSA-5658623 | 8.077782e-01 | 0.093 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 8.077782e-01 | 0.093 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 8.077782e-01 | 0.093 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 8.077782e-01 | 0.093 | 0 | 0 |
| Biosynthesis of DPAn-3-derived maresins | R-HSA-9026290 | 8.077782e-01 | 0.093 | 0 | 0 |
| Synthesis of PIPs at the ER membrane | R-HSA-1483248 | 8.077782e-01 | 0.093 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 8.077782e-01 | 0.093 | 0 | 0 |
| Transport of RCbl within the body | R-HSA-9758890 | 8.077782e-01 | 0.093 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 8.077782e-01 | 0.093 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 8.088525e-01 | 0.092 | 1 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 8.088525e-01 | 0.092 | 1 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 8.099506e-01 | 0.092 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 8.099506e-01 | 0.092 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 8.099513e-01 | 0.092 | 0 | 0 |
| SHC-mediated cascade:FGFR3 | R-HSA-5654704 | 8.100601e-01 | 0.091 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 8.100601e-01 | 0.091 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 8.100601e-01 | 0.091 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 8.100601e-01 | 0.091 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 8.100601e-01 | 0.091 | 1 | 1 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 8.113190e-01 | 0.091 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 8.113190e-01 | 0.091 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 8.113335e-01 | 0.091 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 8.153158e-01 | 0.089 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 8.170489e-01 | 0.088 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 8.184491e-01 | 0.087 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 8.219753e-01 | 0.085 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 8.250749e-01 | 0.084 | 0 | 0 |
| SHC-mediated cascade:FGFR4 | R-HSA-5654719 | 8.262862e-01 | 0.083 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 8.262862e-01 | 0.083 | 0 | 0 |
| Glutathione synthesis and recycling | R-HSA-174403 | 8.262862e-01 | 0.083 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 8.262862e-01 | 0.083 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 8.262862e-01 | 0.083 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 8.269842e-01 | 0.083 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 8.274196e-01 | 0.082 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 8.274196e-01 | 0.082 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 8.291473e-01 | 0.081 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | R-HSA-3772470 | 8.291473e-01 | 0.081 | 0 | 0 |
| Activated NTRK2 signals through RAS | R-HSA-9026519 | 8.291473e-01 | 0.081 | 0 | 0 |
| Signaling by activated point mutants of FGFR1 | R-HSA-1839122 | 8.291473e-01 | 0.081 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 8.291473e-01 | 0.081 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 8.291473e-01 | 0.081 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 8.291473e-01 | 0.081 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 8.305247e-01 | 0.081 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 8.320634e-01 | 0.080 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 8.333207e-01 | 0.079 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 8.333207e-01 | 0.079 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 8.358034e-01 | 0.078 | 1 | 0 |
| G1/S Transition | R-HSA-69206 | 8.381048e-01 | 0.077 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 8.412534e-01 | 0.075 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 8.412534e-01 | 0.075 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 8.412534e-01 | 0.075 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 8.412534e-01 | 0.075 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 8.412534e-01 | 0.075 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 8.412534e-01 | 0.075 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 8.435043e-01 | 0.074 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 8.435043e-01 | 0.074 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 8.456868e-01 | 0.073 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 8.463950e-01 | 0.072 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 8.471041e-01 | 0.072 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 8.481420e-01 | 0.072 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 8.481420e-01 | 0.072 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 8.481420e-01 | 0.072 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 8.481420e-01 | 0.072 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 8.481420e-01 | 0.072 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 8.481420e-01 | 0.072 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 8.481420e-01 | 0.072 | 0 | 0 |
| SHC-related events triggered by IGF1R | R-HSA-2428933 | 8.481420e-01 | 0.072 | 0 | 0 |
| Biosynthesis of DPAn-3-derived protectins and resolvins | R-HSA-9026286 | 8.481420e-01 | 0.072 | 0 | 0 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 8.481420e-01 | 0.072 | 0 | 0 |
| Diseases associated with surfactant metabolism | R-HSA-5687613 | 8.481420e-01 | 0.072 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 8.481420e-01 | 0.072 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 8.481420e-01 | 0.072 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 8.481420e-01 | 0.072 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 8.481420e-01 | 0.072 | 0 | 0 |
| Erythrocytes take up oxygen and release carbon dioxide | R-HSA-1247673 | 8.481420e-01 | 0.072 | 0 | 0 |
| Estrogen biosynthesis | R-HSA-193144 | 8.481420e-01 | 0.072 | 0 | 0 |
| Reversal of alkylation damage by DNA dioxygenases | R-HSA-73943 | 8.481420e-01 | 0.072 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 8.486215e-01 | 0.071 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 8.490059e-01 | 0.071 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 8.496518e-01 | 0.071 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 8.531691e-01 | 0.069 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 8.531691e-01 | 0.069 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 8.538678e-01 | 0.069 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 8.550409e-01 | 0.068 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 8.550409e-01 | 0.068 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 8.550409e-01 | 0.068 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 8.550409e-01 | 0.068 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 8.563217e-01 | 0.067 | 1 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 8.593532e-01 | 0.066 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 8.598277e-01 | 0.066 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 8.603760e-01 | 0.065 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 8.623316e-01 | 0.064 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 8.623316e-01 | 0.064 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 8.634596e-01 | 0.064 | 0 | 0 |
| Adenylate cyclase activating pathway | R-HSA-170660 | 8.650258e-01 | 0.063 | 0 | 0 |
| FGFR2c ligand binding and activation | R-HSA-190375 | 8.650258e-01 | 0.063 | 0 | 0 |
| FGFR1c ligand binding and activation | R-HSA-190373 | 8.650258e-01 | 0.063 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 8.650258e-01 | 0.063 | 0 | 0 |
| FGFR4 ligand binding and activation | R-HSA-190322 | 8.650258e-01 | 0.063 | 0 | 0 |
| Signaling by activated point mutants of FGFR3 | R-HSA-1839130 | 8.650258e-01 | 0.063 | 0 | 0 |
| Chylomicron remodeling | R-HSA-8963901 | 8.650258e-01 | 0.063 | 0 | 0 |
| Mtb iron assimilation by chelation | R-HSA-1222449 | 8.650258e-01 | 0.063 | 0 | 0 |
| Reversible hydration of carbon dioxide | R-HSA-1475029 | 8.650258e-01 | 0.063 | 0 | 0 |
| FGFR3 mutant receptor activation | R-HSA-2033514 | 8.650258e-01 | 0.063 | 0 | 0 |
| Acyl chain remodeling of DAG and TAG | R-HSA-1482883 | 8.650258e-01 | 0.063 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 8.650258e-01 | 0.063 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 8.650258e-01 | 0.063 | 0 | 0 |
| SHC-mediated cascade:FGFR1 | R-HSA-5654688 | 8.677262e-01 | 0.062 | 0 | 0 |
| Assembly of active LPL and LIPC lipase complexes | R-HSA-8963889 | 8.677262e-01 | 0.062 | 0 | 0 |
| TNFs bind their physiological receptors | R-HSA-5669034 | 8.677262e-01 | 0.062 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 8.687769e-01 | 0.061 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 8.691342e-01 | 0.061 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 8.694093e-01 | 0.061 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 8.709874e-01 | 0.060 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 8.709874e-01 | 0.060 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 8.709874e-01 | 0.060 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 8.710090e-01 | 0.060 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 8.710327e-01 | 0.060 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 8.793836e-01 | 0.056 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 8.793836e-01 | 0.056 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 8.800334e-01 | 0.056 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 8.800334e-01 | 0.056 | 0 | 0 |
| Retrograde neurotrophin signalling | R-HSA-177504 | 8.800334e-01 | 0.056 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 8.800334e-01 | 0.056 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 8.800334e-01 | 0.056 | 0 | 0 |
| FGFR3c ligand binding and activation | R-HSA-190372 | 8.800334e-01 | 0.056 | 0 | 0 |
| Biosynthesis of E-series 18(R)-resolvins | R-HSA-9023661 | 8.800334e-01 | 0.056 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 8.800334e-01 | 0.056 | 0 | 0 |
| Prolactin receptor signaling | R-HSA-1170546 | 8.800334e-01 | 0.056 | 0 | 0 |
| Vitamin B2 (riboflavin) metabolism | R-HSA-196843 | 8.800334e-01 | 0.056 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 8.800334e-01 | 0.056 | 0 | 0 |
| Malate-aspartate shuttle | R-HSA-9856872 | 8.800334e-01 | 0.056 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 8.800334e-01 | 0.056 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 8.800334e-01 | 0.056 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 8.800334e-01 | 0.056 | 0 | 0 |
| P2Y receptors | R-HSA-417957 | 8.800334e-01 | 0.056 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 8.803977e-01 | 0.055 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 8.808791e-01 | 0.055 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 8.808791e-01 | 0.055 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 8.808791e-01 | 0.055 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 8.808791e-01 | 0.055 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 8.812229e-01 | 0.055 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 8.851389e-01 | 0.053 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 8.862167e-01 | 0.052 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 8.868025e-01 | 0.052 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 8.869788e-01 | 0.052 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 8.900850e-01 | 0.051 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 8.900850e-01 | 0.051 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 8.900850e-01 | 0.051 | 0 | 0 |
| Voltage gated Potassium channels | R-HSA-1296072 | 8.900896e-01 | 0.051 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 8.900896e-01 | 0.051 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 8.920094e-01 | 0.050 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 8.931977e-01 | 0.049 | 0 | 0 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | R-HSA-8948700 | 8.933731e-01 | 0.049 | 0 | 0 |
| Adenylate cyclase inhibitory pathway | R-HSA-170670 | 8.933731e-01 | 0.049 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 8.933731e-01 | 0.049 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 8.933731e-01 | 0.049 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 8.933731e-01 | 0.049 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 8.933731e-01 | 0.049 | 0 | 0 |
| Protein lipoylation | R-HSA-9857492 | 8.933731e-01 | 0.049 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 8.933731e-01 | 0.049 | 0 | 0 |
| Signaling by Activin | R-HSA-1502540 | 8.933731e-01 | 0.049 | 0 | 0 |
| Lysosphingolipid and LPA receptors | R-HSA-419408 | 8.933731e-01 | 0.049 | 0 | 0 |
| Biotin transport and metabolism | R-HSA-196780 | 8.933731e-01 | 0.049 | 0 | 0 |
| FGFR3 ligand binding and activation | R-HSA-190239 | 8.933731e-01 | 0.049 | 0 | 0 |
| Signaling by PDGFRA extracellular domain mutants | R-HSA-9673770 | 8.933731e-01 | 0.049 | 0 | 0 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | R-HSA-9673767 | 8.933731e-01 | 0.049 | 0 | 0 |
| Other semaphorin interactions | R-HSA-416700 | 8.933731e-01 | 0.049 | 0 | 0 |
| DNA Damage Reversal | R-HSA-73942 | 8.933731e-01 | 0.049 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 8.948371e-01 | 0.048 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 8.950984e-01 | 0.048 | 0 | 0 |
| SHC-mediated cascade:FGFR2 | R-HSA-5654699 | 8.998987e-01 | 0.046 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 8.998987e-01 | 0.046 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 8.998987e-01 | 0.046 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 8.998987e-01 | 0.046 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.011453e-01 | 0.045 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 9.012199e-01 | 0.045 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 9.012199e-01 | 0.045 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 9.022899e-01 | 0.045 | 0 | 0 |
| Defective GALNT3 causes HFTC | R-HSA-5083625 | 9.052302e-01 | 0.043 | 0 | 0 |
| Defective GALNT12 causes CRCS1 | R-HSA-5083636 | 9.052302e-01 | 0.043 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 9.052302e-01 | 0.043 | 0 | 0 |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | R-HSA-434316 | 9.052302e-01 | 0.043 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 9.052302e-01 | 0.043 | 0 | 0 |
| Fructose catabolism | R-HSA-70350 | 9.052302e-01 | 0.043 | 0 | 0 |
| Induction of Cell-Cell Fusion | R-HSA-9733458 | 9.052302e-01 | 0.043 | 0 | 0 |
| Synthesis of wybutosine at G37 of tRNA(Phe) | R-HSA-6782861 | 9.052302e-01 | 0.043 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 9.052302e-01 | 0.043 | 0 | 0 |
| Atorvastatin ADME | R-HSA-9754706 | 9.052302e-01 | 0.043 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 9.063697e-01 | 0.043 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 9.066174e-01 | 0.043 | 0 | 0 |
| Pyrimidine salvage | R-HSA-73614 | 9.088899e-01 | 0.041 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 9.090927e-01 | 0.041 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 9.094904e-01 | 0.041 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.098555e-01 | 0.041 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 9.116089e-01 | 0.040 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 9.116089e-01 | 0.040 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 9.116089e-01 | 0.040 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 9.138739e-01 | 0.039 | 0 | 0 |
| Antigen processing: Ub, ATP-independent proteasomal degradation | R-HSA-9912633 | 9.157693e-01 | 0.038 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 9.157693e-01 | 0.038 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 9.157693e-01 | 0.038 | 0 | 0 |
| Glycine degradation | R-HSA-6783984 | 9.157693e-01 | 0.038 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 9.157693e-01 | 0.038 | 0 | 0 |
| SHC1 events in ERBB4 signaling | R-HSA-1250347 | 9.157693e-01 | 0.038 | 0 | 0 |
| Vitamin B6 activation to pyridoxal phosphate | R-HSA-964975 | 9.157693e-01 | 0.038 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 9.157693e-01 | 0.038 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 9.157693e-01 | 0.038 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 9.157693e-01 | 0.038 | 0 | 0 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | R-HSA-9651496 | 9.157693e-01 | 0.038 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 9.171199e-01 | 0.038 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.176745e-01 | 0.037 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 9.196492e-01 | 0.036 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 9.208606e-01 | 0.036 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 9.208606e-01 | 0.036 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 9.219172e-01 | 0.035 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 9.219172e-01 | 0.035 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 9.243272e-01 | 0.034 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 9.243272e-01 | 0.034 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 9.246470e-01 | 0.034 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 9.246470e-01 | 0.034 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 9.246470e-01 | 0.034 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 9.246470e-01 | 0.034 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 9.250795e-01 | 0.034 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 9.251370e-01 | 0.034 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 9.251370e-01 | 0.034 | 0 | 0 |
| Defective C1GALT1C1 causes TNPS | R-HSA-5083632 | 9.251370e-01 | 0.034 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 9.251370e-01 | 0.034 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 9.251370e-01 | 0.034 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 9.251370e-01 | 0.034 | 0 | 0 |
| Biosynthesis of aspirin-triggered D-series resolvins | R-HSA-9020265 | 9.251370e-01 | 0.034 | 0 | 0 |
| Catecholamine biosynthesis | R-HSA-209905 | 9.251370e-01 | 0.034 | 0 | 0 |
| Sulfide oxidation to sulfate | R-HSA-1614517 | 9.251370e-01 | 0.034 | 0 | 0 |
| GDP-fucose biosynthesis | R-HSA-6787639 | 9.251370e-01 | 0.034 | 0 | 0 |
| Choline catabolism | R-HSA-6798163 | 9.251370e-01 | 0.034 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 9.251370e-01 | 0.034 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 9.251370e-01 | 0.034 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 9.272111e-01 | 0.033 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 9.272111e-01 | 0.033 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 9.272111e-01 | 0.033 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 9.272111e-01 | 0.033 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 9.274634e-01 | 0.033 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 9.301814e-01 | 0.031 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 9.313612e-01 | 0.031 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 9.315255e-01 | 0.031 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 9.315255e-01 | 0.031 | 0 | 0 |
| Synthesis of glycosylphosphatidylinositol (GPI) | R-HSA-162710 | 9.315255e-01 | 0.031 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 9.331747e-01 | 0.030 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 9.334634e-01 | 0.030 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 9.334634e-01 | 0.030 | 0 | 0 |
| Activated point mutants of FGFR2 | R-HSA-2033519 | 9.334634e-01 | 0.030 | 0 | 0 |
| FGFR1 ligand binding and activation | R-HSA-190242 | 9.334634e-01 | 0.030 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 9.334634e-01 | 0.030 | 0 | 0 |
| Biosynthesis of Lipoxins (LX) | R-HSA-2142700 | 9.334634e-01 | 0.030 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 9.334634e-01 | 0.030 | 0 | 0 |
| Organic anion transport by SLC5/17/25 transporters | R-HSA-428643 | 9.334634e-01 | 0.030 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 9.334634e-01 | 0.030 | 0 | 0 |
| Nucleotide-like (purinergic) receptors | R-HSA-418038 | 9.334634e-01 | 0.030 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 9.334634e-01 | 0.030 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.344461e-01 | 0.029 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 9.362296e-01 | 0.029 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.375422e-01 | 0.028 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 9.378067e-01 | 0.028 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 9.378067e-01 | 0.028 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 9.380130e-01 | 0.028 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.380130e-01 | 0.028 | 0 | 0 |
| Pre-NOTCH Processing in Golgi | R-HSA-1912420 | 9.408641e-01 | 0.026 | 0 | 0 |
| Pyrimidine biosynthesis | R-HSA-500753 | 9.408641e-01 | 0.026 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 9.408641e-01 | 0.026 | 0 | 0 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 9.408641e-01 | 0.026 | 0 | 0 |
| Synthesis of 5-eicosatetraenoic acids | R-HSA-2142688 | 9.408641e-01 | 0.026 | 0 | 0 |
| O2/CO2 exchange in erythrocytes | R-HSA-1480926 | 9.408641e-01 | 0.026 | 0 | 0 |
| Diseases of hemostasis | R-HSA-9671793 | 9.408641e-01 | 0.026 | 0 | 0 |
| Erythrocytes take up carbon dioxide and release oxygen | R-HSA-1237044 | 9.408641e-01 | 0.026 | 0 | 0 |
| Strand-asynchronous mitochondrial DNA replication | R-HSA-9913635 | 9.408641e-01 | 0.026 | 0 | 0 |
| Metabolism of amine-derived hormones | R-HSA-209776 | 9.425632e-01 | 0.026 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 9.435382e-01 | 0.025 | 0 | 0 |
| Defective B3GALTL causes PpS | R-HSA-5083635 | 9.435382e-01 | 0.025 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 9.435560e-01 | 0.025 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 9.436756e-01 | 0.025 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 9.446634e-01 | 0.025 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 9.458680e-01 | 0.024 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 9.463828e-01 | 0.024 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 9.468796e-01 | 0.024 | 0 | 0 |
| Regulation of PD-L1(CD274) translation | R-HSA-9909620 | 9.474420e-01 | 0.023 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 9.474420e-01 | 0.023 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 9.474420e-01 | 0.023 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 9.474420e-01 | 0.023 | 0 | 0 |
| Pregnenolone biosynthesis | R-HSA-196108 | 9.474420e-01 | 0.023 | 0 | 0 |
| Eicosanoid ligand-binding receptors | R-HSA-391903 | 9.474420e-01 | 0.023 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 9.481989e-01 | 0.023 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 9.481989e-01 | 0.023 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 9.481989e-01 | 0.023 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 9.487646e-01 | 0.023 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 9.487646e-01 | 0.023 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 9.487646e-01 | 0.023 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 9.517280e-01 | 0.021 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 9.520208e-01 | 0.021 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 9.524841e-01 | 0.021 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 9.524841e-01 | 0.021 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 9.532886e-01 | 0.021 | 0 | 0 |
| FGFR2 ligand binding and activation | R-HSA-190241 | 9.532886e-01 | 0.021 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 9.532886e-01 | 0.021 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 9.532886e-01 | 0.021 | 0 | 0 |
| Matriglycan biosynthesis on DAG1 | R-HSA-9939291 | 9.532886e-01 | 0.021 | 0 | 0 |
| Biosynthesis of E-series 18(S)-resolvins | R-HSA-9018896 | 9.532886e-01 | 0.021 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 9.532886e-01 | 0.021 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 9.532886e-01 | 0.021 | 0 | 0 |
| Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 9.532886e-01 | 0.021 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 9.532886e-01 | 0.021 | 0 | 0 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 9.532886e-01 | 0.021 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 9.532886e-01 | 0.021 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 9.535274e-01 | 0.021 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 9.535274e-01 | 0.021 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 9.535274e-01 | 0.021 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 9.535274e-01 | 0.021 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 9.546331e-01 | 0.020 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.546331e-01 | 0.020 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 9.564362e-01 | 0.019 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 9.566852e-01 | 0.019 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 9.566852e-01 | 0.019 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 9.566852e-01 | 0.019 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 9.578649e-01 | 0.019 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 9.578649e-01 | 0.019 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 9.578649e-01 | 0.019 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 9.579985e-01 | 0.019 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 9.584851e-01 | 0.018 | 0 | 0 |
| Molybdenum cofactor biosynthesis | R-HSA-947581 | 9.584851e-01 | 0.018 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 9.584851e-01 | 0.018 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.605086e-01 | 0.017 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.613309e-01 | 0.017 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 9.618129e-01 | 0.017 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 9.618129e-01 | 0.017 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.618129e-01 | 0.017 | 0 | 0 |
| Biosynthesis of D-series resolvins | R-HSA-9018676 | 9.631038e-01 | 0.016 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 9.631038e-01 | 0.016 | 0 | 0 |
| Fructose metabolism | R-HSA-5652084 | 9.631038e-01 | 0.016 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 9.631038e-01 | 0.016 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.634334e-01 | 0.016 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 9.643246e-01 | 0.016 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 9.643533e-01 | 0.016 | 0 | 0 |
| O-glycosylation of TSR domain-containing proteins | R-HSA-5173214 | 9.654042e-01 | 0.015 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 9.654042e-01 | 0.015 | 0 | 0 |
| SLC-mediated transport of organic cations | R-HSA-549127 | 9.654042e-01 | 0.015 | 0 | 0 |
| Collagen chain trimerization | R-HSA-8948216 | 9.654042e-01 | 0.015 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.657212e-01 | 0.015 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.665771e-01 | 0.015 | 0 | 0 |
| Regulation of PTEN mRNA translation | R-HSA-8943723 | 9.672089e-01 | 0.014 | 0 | 0 |
| Termination of O-glycan biosynthesis | R-HSA-977068 | 9.672089e-01 | 0.014 | 0 | 0 |
| Free fatty acids regulate insulin secretion | R-HSA-400451 | 9.672089e-01 | 0.014 | 0 | 0 |
| Synthesis of pyrophosphates in the cytosol | R-HSA-1855167 | 9.672089e-01 | 0.014 | 0 | 0 |
| Organic anion transport by SLCO transporters | R-HSA-879518 | 9.672089e-01 | 0.014 | 0 | 0 |
| Biosynthesis of maresins | R-HSA-9018682 | 9.672089e-01 | 0.014 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 9.677372e-01 | 0.014 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.681024e-01 | 0.014 | 1 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 9.686694e-01 | 0.014 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 9.693621e-01 | 0.014 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 9.693621e-01 | 0.014 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 9.700276e-01 | 0.013 | 0 | 0 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 9.708574e-01 | 0.013 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 9.708574e-01 | 0.013 | 0 | 0 |
| Synthesis of dolichyl-phosphate | R-HSA-446199 | 9.708574e-01 | 0.013 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 9.708574e-01 | 0.013 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 9.716365e-01 | 0.012 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 9.716365e-01 | 0.012 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 9.716365e-01 | 0.012 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 9.719737e-01 | 0.012 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 9.721068e-01 | 0.012 | 0 | 0 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 9.741002e-01 | 0.011 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 9.741002e-01 | 0.011 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 9.741002e-01 | 0.011 | 0 | 0 |
| Alpha-oxidation of phytanate | R-HSA-389599 | 9.741002e-01 | 0.011 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 9.741002e-01 | 0.011 | 0 | 0 |
| Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives | R-HSA-9027604 | 9.741002e-01 | 0.011 | 0 | 0 |
| Fertilization | R-HSA-1187000 | 9.741002e-01 | 0.011 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.742695e-01 | 0.011 | 0 | 0 |
| rRNA processing in the mitochondrion | R-HSA-8868766 | 9.743315e-01 | 0.011 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 9.743733e-01 | 0.011 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 9.743733e-01 | 0.011 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.751336e-01 | 0.011 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 9.752279e-01 | 0.011 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 9.758798e-01 | 0.011 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 9.758798e-01 | 0.011 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 9.767781e-01 | 0.010 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 9.767781e-01 | 0.010 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 9.767933e-01 | 0.010 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.769823e-01 | 0.010 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 9.769823e-01 | 0.010 | 0 | 0 |
| Urea cycle | R-HSA-70635 | 9.769823e-01 | 0.010 | 0 | 0 |
| Abacavir ADME | R-HSA-2161522 | 9.769823e-01 | 0.010 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.782038e-01 | 0.010 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 9.785994e-01 | 0.009 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 9.795439e-01 | 0.009 | 0 | 0 |
| Biosynthesis of DPAn-3 SPMs | R-HSA-9025094 | 9.795439e-01 | 0.009 | 0 | 0 |
| Triglyceride biosynthesis | R-HSA-75109 | 9.795439e-01 | 0.009 | 0 | 0 |
| Synthesis of PE | R-HSA-1483213 | 9.795439e-01 | 0.009 | 0 | 0 |
| Synthesis of bile acids and bile salts via 27-hydroxycholesterol | R-HSA-193807 | 9.795439e-01 | 0.009 | 0 | 0 |
| Signaling by BMP | R-HSA-201451 | 9.795439e-01 | 0.009 | 0 | 0 |
| Immune System | R-HSA-168256 | 9.795535e-01 | 0.009 | 1 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 9.804547e-01 | 0.009 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 9.810121e-01 | 0.008 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 9.810121e-01 | 0.008 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.815660e-01 | 0.008 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.815660e-01 | 0.008 | 0 | 0 |
| Prednisone ADME | R-HSA-9757110 | 9.818205e-01 | 0.008 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 9.818205e-01 | 0.008 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 9.818205e-01 | 0.008 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 9.828379e-01 | 0.008 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.830571e-01 | 0.007 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.837149e-01 | 0.007 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 9.838332e-01 | 0.007 | 0 | 0 |
| Thyroxine biosynthesis | R-HSA-209968 | 9.838439e-01 | 0.007 | 0 | 0 |
| Biosynthesis of EPA-derived SPMs | R-HSA-9018679 | 9.838439e-01 | 0.007 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 9.838439e-01 | 0.007 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 9.838439e-01 | 0.007 | 0 | 0 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | R-HSA-2142691 | 9.844926e-01 | 0.007 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 9.856421e-01 | 0.006 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 9.859918e-01 | 0.006 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 9.859918e-01 | 0.006 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.860018e-01 | 0.006 | 1 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 9.864504e-01 | 0.006 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.868690e-01 | 0.006 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.868742e-01 | 0.006 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 9.870975e-01 | 0.006 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 9.872404e-01 | 0.006 | 0 | 0 |
| Biosynthesis of DPA-derived SPMs | R-HSA-9018683 | 9.872404e-01 | 0.006 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 9.872404e-01 | 0.006 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 9.872404e-01 | 0.006 | 0 | 0 |
| Nucleotide salvage | R-HSA-8956321 | 9.876470e-01 | 0.005 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.876470e-01 | 0.005 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 9.879535e-01 | 0.005 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 9.885785e-01 | 0.005 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 9.886607e-01 | 0.005 | 0 | 0 |
| DAG1 glycosylations | R-HSA-8931838 | 9.886607e-01 | 0.005 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.886607e-01 | 0.005 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.887416e-01 | 0.005 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 9.889479e-01 | 0.005 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.892019e-01 | 0.005 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.892019e-01 | 0.005 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 9.896908e-01 | 0.005 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.896908e-01 | 0.005 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 9.896908e-01 | 0.005 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 9.897003e-01 | 0.004 | 0 | 0 |
| Recycling of bile acids and salts | R-HSA-159418 | 9.899231e-01 | 0.004 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 9.899924e-01 | 0.004 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 9.910450e-01 | 0.004 | 0 | 0 |
| Heme degradation | R-HSA-189483 | 9.910450e-01 | 0.004 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.920420e-01 | 0.003 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 9.920420e-01 | 0.003 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 9.920420e-01 | 0.003 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 9.920420e-01 | 0.003 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 9.920420e-01 | 0.003 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 9.920420e-01 | 0.003 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 9.920420e-01 | 0.003 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 9.927770e-01 | 0.003 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 9.929281e-01 | 0.003 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 9.929281e-01 | 0.003 | 0 | 0 |
| Defects in vitamin and cofactor metabolism | R-HSA-3296482 | 9.929281e-01 | 0.003 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 9.929281e-01 | 0.003 | 0 | 0 |
| Synthesis of bile acids and bile salts via 24-hydroxycholesterol | R-HSA-193775 | 9.929281e-01 | 0.003 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.929536e-01 | 0.003 | 0 | 0 |
| Nicotinate metabolism | R-HSA-196807 | 9.929536e-01 | 0.003 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 9.932606e-01 | 0.003 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.937156e-01 | 0.003 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 9.937156e-01 | 0.003 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 9.937355e-01 | 0.003 | 1 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 9.938457e-01 | 0.003 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 9.944154e-01 | 0.002 | 0 | 0 |
| NCAM1 interactions | R-HSA-419037 | 9.944154e-01 | 0.002 | 0 | 0 |
| Beta-oxidation of very long chain fatty acids | R-HSA-390247 | 9.944154e-01 | 0.002 | 0 | 0 |
| Lysine catabolism | R-HSA-71064 | 9.944154e-01 | 0.002 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 9.950009e-01 | 0.002 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.950009e-01 | 0.002 | 0 | 0 |
| Purine salvage | R-HSA-74217 | 9.950373e-01 | 0.002 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 9.950373e-01 | 0.002 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.951816e-01 | 0.002 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 9.955900e-01 | 0.002 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 9.955900e-01 | 0.002 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 9.955900e-01 | 0.002 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 9.956795e-01 | 0.002 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.959426e-01 | 0.002 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.959426e-01 | 0.002 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 9.961651e-01 | 0.002 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 9.962514e-01 | 0.002 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.964228e-01 | 0.002 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 9.965177e-01 | 0.002 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 9.965177e-01 | 0.002 | 0 | 0 |
| Aflatoxin activation and detoxification | R-HSA-5423646 | 9.965177e-01 | 0.002 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.967094e-01 | 0.001 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 9.967188e-01 | 0.001 | 0 | 0 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 9.969056e-01 | 0.001 | 0 | 0 |
| Signaling by Retinoic Acid | R-HSA-5362517 | 9.970375e-01 | 0.001 | 0 | 0 |
| Glutathione conjugation | R-HSA-156590 | 9.970375e-01 | 0.001 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 9.972503e-01 | 0.001 | 0 | 0 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 9.972503e-01 | 0.001 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 9.975466e-01 | 0.001 | 0 | 0 |
| Pyrimidine catabolism | R-HSA-73621 | 9.975566e-01 | 0.001 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 9.975885e-01 | 0.001 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.976199e-01 | 0.001 | 0 | 0 |
| Protein folding | R-HSA-391251 | 9.977751e-01 | 0.001 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 9.978288e-01 | 0.001 | 0 | 0 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | R-HSA-196741 | 9.978288e-01 | 0.001 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.980707e-01 | 0.001 | 0 | 0 |
| Degradation of cysteine and homocysteine | R-HSA-1614558 | 9.980707e-01 | 0.001 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 9.980805e-01 | 0.001 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.984263e-01 | 0.001 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.984767e-01 | 0.001 | 0 | 0 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | R-HSA-193368 | 9.985864e-01 | 0.001 | 0 | 0 |
| Metabolism of steroid hormones | R-HSA-196071 | 9.985864e-01 | 0.001 | 0 | 0 |
| O-linked glycosylation of mucins | R-HSA-913709 | 9.987289e-01 | 0.001 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 9.987973e-01 | 0.001 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 9.987973e-01 | 0.001 | 0 | 0 |
| Glyoxylate metabolism and glycine degradation | R-HSA-389661 | 9.987973e-01 | 0.001 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 9.988294e-01 | 0.001 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 9.988341e-01 | 0.001 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 9.990326e-01 | 0.000 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.990505e-01 | 0.000 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 9.990505e-01 | 0.000 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.990769e-01 | 0.000 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.991657e-01 | 0.000 | 0 | 0 |
| Purine catabolism | R-HSA-74259 | 9.991705e-01 | 0.000 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.992547e-01 | 0.000 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.993478e-01 | 0.000 | 1 | 0 |
| Digestion | R-HSA-8935690 | 9.994742e-01 | 0.000 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 9.995644e-01 | 0.000 | 0 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.995644e-01 | 0.000 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.995876e-01 | 0.000 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.996312e-01 | 0.000 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 9.996312e-01 | 0.000 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 9.996723e-01 | 0.000 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.996723e-01 | 0.000 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.996849e-01 | 0.000 | 0 | 0 |
| Endogenous sterols | R-HSA-211976 | 9.997088e-01 | 0.000 | 0 | 0 |
| Digestion and absorption | R-HSA-8963743 | 9.997702e-01 | 0.000 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 9.997806e-01 | 0.000 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 9.997887e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.998051e-01 | 0.000 | 0 | 0 |
| Latent infection - Other responses of Mtb to phagocytosis | R-HSA-1222499 | 9.998186e-01 | 0.000 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.998399e-01 | 0.000 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.998566e-01 | 0.000 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.998739e-01 | 0.000 | 0 | 0 |
| Post-translational modification: synthesis of GPI-anchored proteins | R-HSA-163125 | 9.998782e-01 | 0.000 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.998936e-01 | 0.000 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 9.998963e-01 | 0.000 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.999108e-01 | 0.000 | 0 | 0 |
| Metabolism of porphyrins | R-HSA-189445 | 9.999108e-01 | 0.000 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 9.999276e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.999282e-01 | 0.000 | 0 | 0 |
| Citric acid cycle (TCA cycle) | R-HSA-71403 | 9.999444e-01 | 0.000 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.999466e-01 | 0.000 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.999557e-01 | 0.000 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.999610e-01 | 0.000 | 0 | 0 |
| Metabolic disorders of biological oxidation enzymes | R-HSA-5579029 | 9.999654e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.999681e-01 | 0.000 | 0 | 0 |
| Biosynthesis of DHA-derived SPMs | R-HSA-9018677 | 9.999727e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.999748e-01 | 0.000 | 0 | 0 |
| Peroxisomal lipid metabolism | R-HSA-390918 | 9.999809e-01 | 0.000 | 0 | 0 |
| Sulfur amino acid metabolism | R-HSA-1614635 | 9.999866e-01 | 0.000 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.999867e-01 | 0.000 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 9.999881e-01 | 0.000 | 0 | 0 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | R-HSA-420499 | 9.999894e-01 | 0.000 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.999897e-01 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 9.999905e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.999915e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.999924e-01 | 0.000 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 9.999961e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.999973e-01 | 0.000 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 9.999980e-01 | 0.000 | 0 | 0 |
| Nucleotide catabolism | R-HSA-8956319 | 9.999993e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999994e-01 | 0.000 | 0 | 0 |
| Sensory perception of taste | R-HSA-9717189 | 9.999995e-01 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 9.999995e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999995e-01 | 0.000 | 0 | 0 |
| Disease | R-HSA-1643685 | 9.999996e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.999999e-01 | 0.000 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.999999e-01 | 0.000 | 0 | 0 |
| Sensory perception of sweet, bitter, and umami (glutamate) taste | R-HSA-9717207 | 9.999999e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999999e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.999999e-01 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 9.999999e-01 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 1.000000e+00 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 1.000000e+00 | 0.000 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 1.000000e+00 | 0.000 | 0 | 0 |
| Translation | R-HSA-72766 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of specialized proresolving mediators (SPMs) | R-HSA-9018678 | 1.000000e+00 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 1.000000e+00 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 1.000000e+00 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 1.000000e+00 | 0.000 | 0 | 0 |
| Cytochrome P450 - arranged by substrate type | R-HSA-211897 | 1.000000e+00 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 1.000000e+00 | 0.000 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 1.000000e+00 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 1.000000e+00 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 1.000000e+00 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
| RSK activation | R-HSA-444257 | 1.000000e+00 | 0.000 | 1 | 1 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Cell Cycle, Mitotic | R-HSA-69278 | 5.218048e-14 | 13.282 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 2.612799e-12 | 11.583 | 0 | 0 |
| M Phase | R-HSA-68886 | 4.009015e-12 | 11.397 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 3.448641e-11 | 10.462 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 9.016232e-11 | 10.045 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 4.367897e-09 | 8.360 | 0 | 0 |
| Kinesins | R-HSA-983189 | 2.543910e-08 | 7.594 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 3.539299e-08 | 7.451 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 8.227074e-08 | 7.085 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 1.304324e-07 | 6.885 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 1.634973e-07 | 6.786 | 1 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 2.244815e-07 | 6.649 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 2.558055e-07 | 6.592 | 1 | 1 |
| Membrane Trafficking | R-HSA-199991 | 3.100821e-07 | 6.509 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 7.349123e-07 | 6.134 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 8.682598e-07 | 6.061 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 9.677592e-07 | 6.014 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 1.026326e-06 | 5.989 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 1.335645e-06 | 5.874 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 1.254749e-06 | 5.901 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 1.271951e-06 | 5.896 | 1 | 1 |
| Mitotic Prophase | R-HSA-68875 | 1.478015e-06 | 5.830 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 1.953330e-06 | 5.709 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 2.064531e-06 | 5.685 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 2.560405e-06 | 5.592 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 2.761417e-06 | 5.559 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 2.574780e-06 | 5.589 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 2.974356e-06 | 5.527 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 2.974356e-06 | 5.527 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 3.808233e-06 | 5.419 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 4.169332e-06 | 5.380 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 4.232705e-06 | 5.373 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 4.232705e-06 | 5.373 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 4.081359e-06 | 5.389 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 4.501088e-06 | 5.347 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 4.855051e-06 | 5.314 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 4.776945e-06 | 5.321 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 5.249428e-06 | 5.280 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 6.183252e-06 | 5.209 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 6.634065e-06 | 5.178 | 1 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 6.555630e-06 | 5.183 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 7.995138e-06 | 5.097 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 8.298828e-06 | 5.081 | 1 | 0 |
| Nervous system development | R-HSA-9675108 | 9.657442e-06 | 5.015 | 1 | 0 |
| DNA methylation | R-HSA-5334118 | 9.983258e-06 | 5.001 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 9.882363e-06 | 5.005 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 1.014351e-05 | 4.994 | 1 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 1.042786e-05 | 4.982 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 1.220416e-05 | 4.913 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 1.294224e-05 | 4.888 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 1.294224e-05 | 4.888 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 1.401082e-05 | 4.854 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 1.438708e-05 | 4.842 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 1.610561e-05 | 4.793 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 1.618939e-05 | 4.791 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 1.962906e-05 | 4.707 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 2.067235e-05 | 4.685 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 2.165890e-05 | 4.664 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 2.311442e-05 | 4.636 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 2.449109e-05 | 4.611 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 2.454872e-05 | 4.610 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 2.530416e-05 | 4.597 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 2.652107e-05 | 4.576 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 2.652107e-05 | 4.576 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 2.892965e-05 | 4.539 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 3.106381e-05 | 4.508 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 3.609386e-05 | 4.443 | 1 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 3.907006e-05 | 4.408 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 3.890011e-05 | 4.410 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 3.995529e-05 | 4.398 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 3.995529e-05 | 4.398 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 4.640135e-05 | 4.333 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 4.999478e-05 | 4.301 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 5.636993e-05 | 4.249 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 5.645371e-05 | 4.248 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 6.379973e-05 | 4.195 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 6.414281e-05 | 4.193 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 6.533414e-05 | 4.185 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 6.728076e-05 | 4.172 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 8.296566e-05 | 4.081 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 8.594742e-05 | 4.066 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 8.767949e-05 | 4.057 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 9.654687e-05 | 4.015 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 1.002344e-04 | 3.999 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 9.966018e-05 | 4.001 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 1.013930e-04 | 3.994 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 1.071437e-04 | 3.970 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 1.153048e-04 | 3.938 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 1.264416e-04 | 3.898 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 1.535299e-04 | 3.814 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 1.549729e-04 | 3.810 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 1.721907e-04 | 3.764 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 1.892159e-04 | 3.723 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 1.866166e-04 | 3.729 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 1.931156e-04 | 3.714 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 2.099005e-04 | 3.678 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 2.170828e-04 | 3.663 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 2.171801e-04 | 3.663 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 2.309883e-04 | 3.636 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 2.310512e-04 | 3.636 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 2.517163e-04 | 3.599 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 2.478934e-04 | 3.606 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 2.815650e-04 | 3.550 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 2.855647e-04 | 3.544 | 1 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 2.909085e-04 | 3.536 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 3.227515e-04 | 3.491 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 3.611374e-04 | 3.442 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 3.611374e-04 | 3.442 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 3.501243e-04 | 3.456 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 3.388520e-04 | 3.470 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 3.388520e-04 | 3.470 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 3.722413e-04 | 3.429 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 3.722413e-04 | 3.429 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 3.823281e-04 | 3.418 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 3.928299e-04 | 3.406 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 4.068378e-04 | 3.391 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 4.068378e-04 | 3.391 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 4.071495e-04 | 3.390 | 0 | 0 |
| Depurination | R-HSA-73927 | 4.529593e-04 | 3.344 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 4.635417e-04 | 3.334 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 4.841815e-04 | 3.315 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 4.875140e-04 | 3.312 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 4.876510e-04 | 3.312 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 4.976628e-04 | 3.303 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 5.597477e-04 | 3.252 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 5.312473e-04 | 3.275 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 5.312473e-04 | 3.275 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 5.164096e-04 | 3.287 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 5.572509e-04 | 3.254 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 5.823492e-04 | 3.235 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 5.857477e-04 | 3.232 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 5.881443e-04 | 3.231 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 5.896882e-04 | 3.229 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 5.907241e-04 | 3.229 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 6.006389e-04 | 3.221 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 6.145843e-04 | 3.211 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 6.334415e-04 | 3.198 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 6.704335e-04 | 3.174 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 6.816918e-04 | 3.166 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 6.924745e-04 | 3.160 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 7.772130e-04 | 3.109 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 7.886425e-04 | 3.103 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 7.327222e-04 | 3.135 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 8.235550e-04 | 3.084 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 1.014904e-03 | 2.994 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 1.074609e-03 | 2.969 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 1.079974e-03 | 2.967 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 1.111861e-03 | 2.954 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 1.145983e-03 | 2.941 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 1.149754e-03 | 2.939 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 1.149754e-03 | 2.939 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 1.187992e-03 | 2.925 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 1.241128e-03 | 2.906 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 1.311839e-03 | 2.882 | 1 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 1.345184e-03 | 2.871 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 1.360836e-03 | 2.866 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 1.463138e-03 | 2.835 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 1.501903e-03 | 2.823 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 1.570726e-03 | 2.804 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 1.624218e-03 | 2.789 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 1.694555e-03 | 2.771 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 1.696842e-03 | 2.770 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 1.741141e-03 | 2.759 | 1 | 1 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 1.741141e-03 | 2.759 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 1.835261e-03 | 2.736 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 2.047547e-03 | 2.689 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 2.047547e-03 | 2.689 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 2.271174e-03 | 2.644 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 2.331010e-03 | 2.632 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 2.340094e-03 | 2.631 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 2.353372e-03 | 2.628 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 2.271174e-03 | 2.644 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 2.296533e-03 | 2.639 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 2.366460e-03 | 2.626 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 2.366460e-03 | 2.626 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 2.379312e-03 | 2.624 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 2.538594e-03 | 2.595 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 2.594956e-03 | 2.586 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 2.756701e-03 | 2.560 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 2.756701e-03 | 2.560 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 2.844117e-03 | 2.546 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 2.912527e-03 | 2.536 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 2.912527e-03 | 2.536 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 2.997106e-03 | 2.523 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 3.304537e-03 | 2.481 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 3.376280e-03 | 2.472 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 3.420919e-03 | 2.466 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 4.068014e-03 | 2.391 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 3.595213e-03 | 2.444 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 3.723744e-03 | 2.429 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 4.123365e-03 | 2.385 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 4.153215e-03 | 2.382 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 4.153215e-03 | 2.382 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 4.208539e-03 | 2.376 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 4.452266e-03 | 2.351 | 0 | 0 |
| Maturation of protein E | R-HSA-9683683 | 4.597385e-03 | 2.337 | 0 | 0 |
| Maturation of protein E | R-HSA-9694493 | 4.597385e-03 | 2.337 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 4.666284e-03 | 2.331 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 4.666284e-03 | 2.331 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 4.776618e-03 | 2.321 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 4.776618e-03 | 2.321 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 4.776618e-03 | 2.321 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 4.783204e-03 | 2.320 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 5.328636e-03 | 2.273 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 5.328636e-03 | 2.273 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 5.911041e-03 | 2.228 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 5.911041e-03 | 2.228 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 5.911041e-03 | 2.228 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 5.424288e-03 | 2.266 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 5.489761e-03 | 2.260 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 5.157290e-03 | 2.288 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 5.328636e-03 | 2.273 | 0 | 0 |
| Translesion synthesis by REV1 | R-HSA-110312 | 5.328636e-03 | 2.273 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 5.911041e-03 | 2.228 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 5.328636e-03 | 2.273 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 5.748402e-03 | 2.240 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 5.328636e-03 | 2.273 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 5.518749e-03 | 2.258 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 5.917111e-03 | 2.228 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 5.963708e-03 | 2.224 | 1 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 6.198802e-03 | 2.208 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 6.333403e-03 | 2.198 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 6.333403e-03 | 2.198 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 6.337261e-03 | 2.198 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 6.475575e-03 | 2.189 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 6.475575e-03 | 2.189 | 0 | 0 |
| ChREBP activates metabolic gene expression | R-HSA-163765 | 6.475575e-03 | 2.189 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 6.688088e-03 | 2.175 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 6.773412e-03 | 2.169 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 6.825215e-03 | 2.166 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 6.908313e-03 | 2.161 | 1 | 1 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 6.908313e-03 | 2.161 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 7.172332e-03 | 2.144 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 7.335673e-03 | 2.135 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 7.682500e-03 | 2.114 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 8.558488e-03 | 2.068 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 8.558488e-03 | 2.068 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 8.482667e-03 | 2.071 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 8.334392e-03 | 2.079 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 8.634161e-03 | 2.064 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 7.750132e-03 | 2.111 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 9.236209e-03 | 2.035 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 8.700045e-03 | 2.060 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 8.700045e-03 | 2.060 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 8.334392e-03 | 2.079 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 8.558488e-03 | 2.068 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 9.065821e-03 | 2.043 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 9.245751e-03 | 2.034 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 9.332061e-03 | 2.030 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 9.359547e-03 | 2.029 | 1 | 0 |
| Cilium Assembly | R-HSA-5617833 | 9.443615e-03 | 2.025 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 9.877523e-03 | 2.005 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 9.879604e-03 | 2.005 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 1.028761e-02 | 1.988 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 1.048090e-02 | 1.980 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 1.065477e-02 | 1.972 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 1.106401e-02 | 1.956 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 1.106401e-02 | 1.956 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 1.179109e-02 | 1.928 | 0 | 0 |
| S Phase | R-HSA-69242 | 1.223888e-02 | 1.912 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 1.263344e-02 | 1.898 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 1.279184e-02 | 1.893 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 1.279184e-02 | 1.893 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 1.279184e-02 | 1.893 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 1.309417e-02 | 1.883 | 0 | 0 |
| RSK activation | R-HSA-444257 | 1.357486e-02 | 1.867 | 1 | 1 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 1.357486e-02 | 1.867 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 1.357486e-02 | 1.867 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 1.357486e-02 | 1.867 | 0 | 0 |
| Modulation by Mtb of host immune system | R-HSA-9637628 | 1.357486e-02 | 1.867 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 1.402810e-02 | 1.853 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 1.528185e-02 | 1.816 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 1.543815e-02 | 1.811 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 1.646509e-02 | 1.783 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 1.675088e-02 | 1.776 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 1.675088e-02 | 1.776 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 1.748355e-02 | 1.757 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 1.748355e-02 | 1.757 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 1.768156e-02 | 1.752 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 1.793810e-02 | 1.746 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 1.804695e-02 | 1.744 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 1.822630e-02 | 1.739 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 1.844119e-02 | 1.734 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 1.844119e-02 | 1.734 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 2.065871e-02 | 1.685 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 2.182075e-02 | 1.661 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 2.078016e-02 | 1.682 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 1.913694e-02 | 1.718 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 2.175602e-02 | 1.662 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 1.947847e-02 | 1.710 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 1.947847e-02 | 1.710 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 2.145951e-02 | 1.668 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 2.186356e-02 | 1.660 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 2.030018e-02 | 1.693 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 2.065871e-02 | 1.685 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 2.388497e-02 | 1.622 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 1.992776e-02 | 1.701 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 2.107892e-02 | 1.676 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 2.142582e-02 | 1.669 | 0 | 0 |
| Toxicity of botulinum toxin type C (botC) | R-HSA-5250971 | 2.065871e-02 | 1.685 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 2.211005e-02 | 1.655 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 2.229226e-02 | 1.652 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 1.968171e-02 | 1.706 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 2.073886e-02 | 1.683 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 2.392102e-02 | 1.621 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 2.403734e-02 | 1.619 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 2.445110e-02 | 1.612 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 2.461864e-02 | 1.609 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 2.461864e-02 | 1.609 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 2.549121e-02 | 1.594 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 2.559491e-02 | 1.592 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 2.559491e-02 | 1.592 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 2.576710e-02 | 1.589 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 2.598121e-02 | 1.585 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 2.724910e-02 | 1.565 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 2.740254e-02 | 1.562 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 2.773472e-02 | 1.557 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 2.773472e-02 | 1.557 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 2.819932e-02 | 1.550 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 2.826042e-02 | 1.549 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 2.836560e-02 | 1.547 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 2.977981e-02 | 1.526 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 2.996989e-02 | 1.523 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 3.026520e-02 | 1.519 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 3.026520e-02 | 1.519 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 3.026520e-02 | 1.519 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 3.026520e-02 | 1.519 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 3.106972e-02 | 1.508 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 3.106972e-02 | 1.508 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 3.111358e-02 | 1.507 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 3.114970e-02 | 1.507 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 3.114970e-02 | 1.507 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 3.350657e-02 | 1.475 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 3.438957e-02 | 1.464 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 3.439669e-02 | 1.463 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 3.568202e-02 | 1.448 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 3.578397e-02 | 1.446 | 1 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 3.579895e-02 | 1.446 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 3.637011e-02 | 1.439 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 3.648640e-02 | 1.438 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperone genes | R-HSA-381183 | 3.648640e-02 | 1.438 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 3.674181e-02 | 1.435 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 3.697995e-02 | 1.432 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 3.697995e-02 | 1.432 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 4.342942e-02 | 1.362 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 4.342942e-02 | 1.362 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 4.342942e-02 | 1.362 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 4.342942e-02 | 1.362 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 4.342942e-02 | 1.362 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 4.342942e-02 | 1.362 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 4.342942e-02 | 1.362 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 4.342942e-02 | 1.362 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 4.342942e-02 | 1.362 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 4.342942e-02 | 1.362 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 4.342942e-02 | 1.362 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 4.342942e-02 | 1.362 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 5.042995e-02 | 1.297 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 5.042995e-02 | 1.297 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 4.988207e-02 | 1.302 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 4.451993e-02 | 1.351 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 4.451993e-02 | 1.351 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 4.168210e-02 | 1.380 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 4.605088e-02 | 1.337 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 4.315871e-02 | 1.365 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 3.867826e-02 | 1.413 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 3.949145e-02 | 1.403 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 4.905040e-02 | 1.309 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 3.819628e-02 | 1.418 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 3.971406e-02 | 1.401 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 4.492922e-02 | 1.347 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 4.059503e-02 | 1.392 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 4.984059e-02 | 1.302 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 4.464695e-02 | 1.350 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 4.451993e-02 | 1.351 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 4.168210e-02 | 1.380 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 5.042995e-02 | 1.297 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 3.812546e-02 | 1.419 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 4.789478e-02 | 1.320 | 0 | 0 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 4.437387e-02 | 1.353 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 4.437387e-02 | 1.353 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 4.437387e-02 | 1.353 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 4.437387e-02 | 1.353 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 4.437387e-02 | 1.353 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 5.087625e-02 | 1.293 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 5.313974e-02 | 1.275 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 5.313974e-02 | 1.275 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 5.313974e-02 | 1.275 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperones | R-HSA-381033 | 5.313974e-02 | 1.275 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 5.330900e-02 | 1.273 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 5.342341e-02 | 1.272 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 5.342341e-02 | 1.272 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 5.354883e-02 | 1.271 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 5.521315e-02 | 1.258 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 5.521315e-02 | 1.258 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 5.644403e-02 | 1.248 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 5.728235e-02 | 1.242 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 5.728235e-02 | 1.242 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 5.733243e-02 | 1.242 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 5.736210e-02 | 1.241 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 5.769446e-02 | 1.239 | 0 | 0 |
| Drug resistance of PDGFR mutants | R-HSA-9674415 | 7.881929e-02 | 1.103 | 0 | 0 |
| PDGFR mutants bind TKIs | R-HSA-9674428 | 7.881929e-02 | 1.103 | 0 | 0 |
| Sorafenib-resistant PDGFR mutants | R-HSA-9674404 | 7.881929e-02 | 1.103 | 0 | 0 |
| Imatinib-resistant PDGFR mutants | R-HSA-9674396 | 7.881929e-02 | 1.103 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 7.881929e-02 | 1.103 | 0 | 0 |
| Sunitinib-resistant PDGFR mutants | R-HSA-9674401 | 7.881929e-02 | 1.103 | 0 | 0 |
| Regorafenib-resistant PDGFR mutants | R-HSA-9674403 | 7.881929e-02 | 1.103 | 0 | 0 |
| Signaling by FGFR1 amplification mutants | R-HSA-1839120 | 6.435955e-02 | 1.191 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 6.435955e-02 | 1.191 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 8.793343e-02 | 1.056 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 6.330003e-02 | 1.199 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 6.330003e-02 | 1.199 | 0 | 0 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | R-HSA-77588 | 6.330003e-02 | 1.199 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 6.330003e-02 | 1.199 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 6.330003e-02 | 1.199 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 6.330003e-02 | 1.199 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 7.752317e-02 | 1.111 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 7.752317e-02 | 1.111 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 7.752317e-02 | 1.111 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 7.752317e-02 | 1.111 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 6.277492e-02 | 1.202 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 7.414035e-02 | 1.130 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 7.414035e-02 | 1.130 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 7.148073e-02 | 1.146 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 7.148073e-02 | 1.146 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 7.148073e-02 | 1.146 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 6.110997e-02 | 1.214 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 8.084584e-02 | 1.092 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 7.374022e-02 | 1.132 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 8.554385e-02 | 1.068 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 7.519833e-02 | 1.124 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 6.898592e-02 | 1.161 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 7.521684e-02 | 1.124 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 7.521684e-02 | 1.124 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 7.822865e-02 | 1.107 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 6.544964e-02 | 1.184 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 7.521684e-02 | 1.124 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 8.530827e-02 | 1.069 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 7.534506e-02 | 1.123 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 7.534506e-02 | 1.123 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 8.554385e-02 | 1.068 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 7.433750e-02 | 1.129 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 6.299920e-02 | 1.201 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 8.283262e-02 | 1.082 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 7.148073e-02 | 1.146 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 6.316858e-02 | 1.199 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 7.752317e-02 | 1.111 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 7.220512e-02 | 1.141 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 6.846968e-02 | 1.165 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 6.277492e-02 | 1.202 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 7.414035e-02 | 1.130 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 6.576893e-02 | 1.182 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 7.752317e-02 | 1.111 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 6.415033e-02 | 1.193 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 7.148073e-02 | 1.146 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 6.823736e-02 | 1.166 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 7.322621e-02 | 1.135 | 1 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 7.401710e-02 | 1.131 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 8.084584e-02 | 1.092 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 6.913659e-02 | 1.160 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 8.678308e-02 | 1.062 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 6.556200e-02 | 1.183 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 7.618666e-02 | 1.118 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 8.554385e-02 | 1.068 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 8.683412e-02 | 1.061 | 1 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 8.102838e-02 | 1.091 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 8.530827e-02 | 1.069 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 6.766646e-02 | 1.170 | 1 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 7.326226e-02 | 1.135 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 6.544964e-02 | 1.184 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 6.235827e-02 | 1.205 | 1 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 8.342612e-02 | 1.079 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 6.277492e-02 | 1.202 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 7.414035e-02 | 1.130 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 8.457736e-02 | 1.073 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 8.457736e-02 | 1.073 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 9.234444e-02 | 1.035 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 9.234444e-02 | 1.035 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 9.300489e-02 | 1.031 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 9.300489e-02 | 1.031 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 9.300489e-02 | 1.031 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 9.329529e-02 | 1.030 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 9.341632e-02 | 1.030 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 9.514584e-02 | 1.022 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 9.615824e-02 | 1.017 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 9.619435e-02 | 1.017 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 9.621862e-02 | 1.017 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 9.621862e-02 | 1.017 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 9.668951e-02 | 1.015 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 9.668951e-02 | 1.015 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 9.698526e-02 | 1.013 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 9.749896e-02 | 1.011 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 9.818844e-02 | 1.008 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 9.841086e-02 | 1.007 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 9.841086e-02 | 1.007 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 9.870264e-02 | 1.006 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 1.008803e-01 | 0.996 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 1.008803e-01 | 0.996 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 1.025191e-01 | 0.989 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 1.025191e-01 | 0.989 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 1.029007e-01 | 0.988 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 1.029317e-01 | 0.987 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 1.037329e-01 | 0.984 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 1.037329e-01 | 0.984 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 1.037329e-01 | 0.984 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 1.042695e-01 | 0.982 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 1.050290e-01 | 0.979 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 1.053604e-01 | 0.977 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 1.053604e-01 | 0.977 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 1.053604e-01 | 0.977 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 1.073111e-01 | 0.969 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 1.086438e-01 | 0.964 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 1.095625e-01 | 0.960 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 1.096416e-01 | 0.960 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 1.096416e-01 | 0.960 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 1.109020e-01 | 0.955 | 1 | 0 |
| IRS activation | R-HSA-74713 | 1.136049e-01 | 0.945 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 1.136049e-01 | 0.945 | 0 | 0 |
| Pyrophosphate hydrolysis | R-HSA-71737 | 1.136049e-01 | 0.945 | 0 | 0 |
| NFE2L2 regulating TCA cycle genes | R-HSA-9818025 | 1.136049e-01 | 0.945 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 1.137800e-01 | 0.944 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 1.139709e-01 | 0.943 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 1.139709e-01 | 0.943 | 1 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 1.139910e-01 | 0.943 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 1.146272e-01 | 0.941 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 1.146272e-01 | 0.941 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 1.147211e-01 | 0.940 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 1.147211e-01 | 0.940 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 1.149352e-01 | 0.940 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 1.197712e-01 | 0.922 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 1.231554e-01 | 0.910 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 1.231554e-01 | 0.910 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 1.249314e-01 | 0.903 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 1.249314e-01 | 0.903 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 1.249314e-01 | 0.903 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 1.249314e-01 | 0.903 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 1.253442e-01 | 0.902 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 1.262391e-01 | 0.899 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 1.273237e-01 | 0.895 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 1.307179e-01 | 0.884 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 1.307179e-01 | 0.884 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 1.334441e-01 | 0.875 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 1.351367e-01 | 0.869 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 1.351367e-01 | 0.869 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 1.374237e-01 | 0.862 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 1.374237e-01 | 0.862 | 1 | 1 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 1.382639e-01 | 0.859 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 1.382639e-01 | 0.859 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 1.402123e-01 | 0.853 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 1.408975e-01 | 0.851 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 1.408975e-01 | 0.851 | 0 | 0 |
| PTK6 Regulates Cell Cycle | R-HSA-8849470 | 1.408975e-01 | 0.851 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 1.408975e-01 | 0.851 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 1.408975e-01 | 0.851 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 1.408975e-01 | 0.851 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 1.408975e-01 | 0.851 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 1.409061e-01 | 0.851 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 1.432358e-01 | 0.844 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 1.514304e-01 | 0.820 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 1.514304e-01 | 0.820 | 0 | 0 |
| Regulation of PAK-2p34 activity by PS-GAP/RHG10 | R-HSA-211728 | 1.514304e-01 | 0.820 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 1.514304e-01 | 0.820 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 1.514304e-01 | 0.820 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 1.514304e-01 | 0.820 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH6 | R-HSA-5632968 | 1.514304e-01 | 0.820 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 2.183221e-01 | 0.661 | 0 | 0 |
| TWIK-releated acid-sensitive K+ channel (TASK) | R-HSA-1299316 | 2.183221e-01 | 0.661 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 2.183221e-01 | 0.661 | 0 | 0 |
| Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) | R-HSA-5619039 | 2.183221e-01 | 0.661 | 0 | 0 |
| Defective GFPT1 causes CMSTA1 | R-HSA-4085023 | 2.183221e-01 | 0.661 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 2.799444e-01 | 0.553 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 2.799444e-01 | 0.553 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 2.799444e-01 | 0.553 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 2.799444e-01 | 0.553 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 1.693966e-01 | 0.771 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 1.693966e-01 | 0.771 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 1.693966e-01 | 0.771 | 0 | 0 |
| Branched-chain ketoacid dehydrogenase kinase deficiency | R-HSA-9912481 | 1.693966e-01 | 0.771 | 0 | 0 |
| Defective HLCS causes multiple carboxylase deficiency | R-HSA-3371599 | 1.987428e-01 | 0.702 | 0 | 0 |
| PTK6 Expression | R-HSA-8849473 | 1.987428e-01 | 0.702 | 0 | 0 |
| SLBP independent Processing of Histone Pre-mRNAs | R-HSA-111367 | 1.987428e-01 | 0.702 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 1.987428e-01 | 0.702 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 1.459387e-01 | 0.836 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 1.855130e-01 | 0.732 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 2.587792e-01 | 0.587 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 2.062490e-01 | 0.686 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 2.062490e-01 | 0.686 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 2.274738e-01 | 0.643 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 2.274738e-01 | 0.643 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 1.507703e-01 | 0.822 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 1.507703e-01 | 0.822 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 2.002650e-01 | 0.698 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 1.771178e-01 | 0.752 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 1.573087e-01 | 0.803 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 2.709836e-01 | 0.567 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 2.709836e-01 | 0.567 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 1.909004e-01 | 0.719 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 1.909004e-01 | 0.719 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 1.909004e-01 | 0.719 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 2.195290e-01 | 0.659 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 1.929177e-01 | 0.715 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 2.878678e-01 | 0.541 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 2.878678e-01 | 0.541 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 2.267588e-01 | 0.644 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 2.801404e-01 | 0.553 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 1.640784e-01 | 0.785 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 2.386945e-01 | 0.622 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 1.610766e-01 | 0.793 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 2.631413e-01 | 0.580 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 2.855429e-01 | 0.544 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 2.756195e-01 | 0.560 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 2.588535e-01 | 0.587 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 2.801404e-01 | 0.553 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 1.929177e-01 | 0.715 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 1.523197e-01 | 0.817 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 1.929177e-01 | 0.715 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 1.677932e-01 | 0.775 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 1.461336e-01 | 0.835 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 1.771178e-01 | 0.752 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 2.709836e-01 | 0.567 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 2.580049e-01 | 0.588 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 1.718953e-01 | 0.765 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 2.062490e-01 | 0.686 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 1.807197e-01 | 0.743 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 2.646494e-01 | 0.577 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 2.161042e-01 | 0.665 | 0 | 0 |
| Protein folding | R-HSA-391251 | 2.223125e-01 | 0.653 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 2.716889e-01 | 0.566 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 2.838319e-01 | 0.547 | 0 | 0 |
| p75NTR regulates axonogenesis | R-HSA-193697 | 2.587792e-01 | 0.587 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 1.909004e-01 | 0.719 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 2.801404e-01 | 0.553 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 2.109138e-01 | 0.676 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 2.508275e-01 | 0.601 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 1.929177e-01 | 0.715 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 2.716889e-01 | 0.566 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 1.601590e-01 | 0.795 | 0 | 0 |
| Axonal growth inhibition (RHOA activation) | R-HSA-193634 | 2.286260e-01 | 0.641 | 0 | 0 |
| Defects in biotin (Btn) metabolism | R-HSA-3323169 | 2.587792e-01 | 0.587 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 2.171573e-01 | 0.663 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 2.195290e-01 | 0.659 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 2.195290e-01 | 0.659 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 2.859925e-01 | 0.544 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 2.646494e-01 | 0.577 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 2.344161e-01 | 0.630 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 2.519886e-01 | 0.599 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 2.698228e-01 | 0.569 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 1.653727e-01 | 0.782 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 2.002650e-01 | 0.698 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 1.807197e-01 | 0.743 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 2.698228e-01 | 0.569 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 1.759000e-01 | 0.755 | 0 | 0 |
| Neurofascin interactions | R-HSA-447043 | 1.693966e-01 | 0.771 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 2.215928e-01 | 0.654 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 2.716889e-01 | 0.566 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 2.716889e-01 | 0.566 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 2.570961e-01 | 0.590 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 1.960522e-01 | 0.708 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 2.299987e-01 | 0.638 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 1.443063e-01 | 0.841 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 2.435222e-01 | 0.613 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 1.564421e-01 | 0.806 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 1.578721e-01 | 0.802 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH2 | R-HSA-5632928 | 2.183221e-01 | 0.661 | 0 | 0 |
| Manipulation of host energy metabolism | R-HSA-9636667 | 2.183221e-01 | 0.661 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 2.799444e-01 | 0.553 | 0 | 0 |
| Interleukin-33 signaling | R-HSA-9014843 | 2.799444e-01 | 0.553 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 1.855130e-01 | 0.732 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 1.688435e-01 | 0.773 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 1.929177e-01 | 0.715 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 1.813045e-01 | 0.742 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 1.922942e-01 | 0.716 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 1.922942e-01 | 0.716 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 2.035431e-01 | 0.691 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 2.414747e-01 | 0.617 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 2.698228e-01 | 0.569 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 2.547480e-01 | 0.594 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 2.758143e-01 | 0.559 | 0 | 0 |
| Biotin transport and metabolism | R-HSA-196780 | 2.062490e-01 | 0.686 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 2.062490e-01 | 0.686 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 2.493622e-01 | 0.603 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 1.929177e-01 | 0.715 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 1.500297e-01 | 0.824 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 2.610073e-01 | 0.583 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 1.523197e-01 | 0.817 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 1.705882e-01 | 0.768 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 1.693966e-01 | 0.771 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 2.343112e-01 | 0.630 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 1.929177e-01 | 0.715 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 2.215928e-01 | 0.654 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 2.092220e-01 | 0.679 | 1 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 1.637311e-01 | 0.786 | 1 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 2.092220e-01 | 0.679 | 1 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 1.813045e-01 | 0.742 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 1.718246e-01 | 0.765 | 1 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 2.859925e-01 | 0.544 | 1 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 2.587792e-01 | 0.587 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 2.274738e-01 | 0.643 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 2.490845e-01 | 0.604 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 1.500297e-01 | 0.824 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 1.913564e-01 | 0.718 | 1 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 1.913564e-01 | 0.718 | 1 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 1.913564e-01 | 0.718 | 1 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 1.855130e-01 | 0.732 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 2.493622e-01 | 0.603 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 2.582820e-01 | 0.588 | 1 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 2.177888e-01 | 0.662 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 1.462190e-01 | 0.835 | 1 | 0 |
| Glycolysis | R-HSA-70171 | 2.074118e-01 | 0.683 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 2.799444e-01 | 0.553 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 1.987428e-01 | 0.702 | 0 | 0 |
| Cation-coupled Chloride cotransporters | R-HSA-426117 | 1.987428e-01 | 0.702 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 2.286260e-01 | 0.641 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 1.837925e-01 | 0.736 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 2.195290e-01 | 0.659 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 1.703714e-01 | 0.769 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 2.274738e-01 | 0.643 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 1.837011e-01 | 0.736 | 0 | 0 |
| ER Quality Control Compartment (ERQC) | R-HSA-901032 | 2.878678e-01 | 0.541 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 2.587792e-01 | 0.587 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 2.587792e-01 | 0.587 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 2.587792e-01 | 0.587 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 1.837925e-01 | 0.736 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 2.878678e-01 | 0.541 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 2.677509e-01 | 0.572 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 1.677932e-01 | 0.775 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 1.461336e-01 | 0.835 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 2.171573e-01 | 0.663 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 2.490845e-01 | 0.604 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 1.909004e-01 | 0.719 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 1.922942e-01 | 0.716 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 2.776590e-01 | 0.556 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 1.677932e-01 | 0.775 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 2.445135e-01 | 0.612 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 1.608327e-01 | 0.794 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 2.859925e-01 | 0.544 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 2.698228e-01 | 0.569 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 2.267588e-01 | 0.644 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 2.882453e-01 | 0.540 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 2.889746e-01 | 0.539 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 2.889746e-01 | 0.539 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 2.889746e-01 | 0.539 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 2.889746e-01 | 0.539 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 2.889746e-01 | 0.539 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 2.889746e-01 | 0.539 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 2.930787e-01 | 0.533 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 2.930787e-01 | 0.533 | 0 | 0 |
| PKA activation | R-HSA-163615 | 2.930787e-01 | 0.533 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 2.930787e-01 | 0.533 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 2.952505e-01 | 0.530 | 1 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 2.995445e-01 | 0.524 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 2.995445e-01 | 0.524 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 3.060742e-01 | 0.514 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 3.060742e-01 | 0.514 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 3.060742e-01 | 0.514 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 3.078499e-01 | 0.512 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 3.093919e-01 | 0.509 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 3.116059e-01 | 0.506 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 3.116059e-01 | 0.506 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 3.116059e-01 | 0.506 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 3.129799e-01 | 0.504 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 3.129799e-01 | 0.504 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 3.136715e-01 | 0.504 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 3.152836e-01 | 0.501 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 3.152836e-01 | 0.501 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 3.152836e-01 | 0.501 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 3.152836e-01 | 0.501 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 3.190183e-01 | 0.496 | 0 | 0 |
| Formation of the posterior neural plate | R-HSA-9832991 | 3.190183e-01 | 0.496 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 3.190183e-01 | 0.496 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 3.199954e-01 | 0.495 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 3.243943e-01 | 0.489 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 3.243943e-01 | 0.489 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 3.249558e-01 | 0.488 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 3.249558e-01 | 0.488 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 3.249558e-01 | 0.488 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 3.268417e-01 | 0.486 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 3.269943e-01 | 0.485 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 3.275178e-01 | 0.485 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 3.275178e-01 | 0.485 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 3.275178e-01 | 0.485 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 3.275178e-01 | 0.485 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 3.279016e-01 | 0.484 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 3.283355e-01 | 0.484 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 3.330505e-01 | 0.477 | 1 | 0 |
| The NLRP1 inflammasome | R-HSA-844455 | 3.367122e-01 | 0.473 | 0 | 0 |
| Axonal growth stimulation | R-HSA-209563 | 3.367122e-01 | 0.473 | 0 | 0 |
| Signaling by plasma membrane FGFR1 fusions | R-HSA-8853336 | 3.367122e-01 | 0.473 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 3.367122e-01 | 0.473 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 3.367122e-01 | 0.473 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 3.367122e-01 | 0.473 | 0 | 0 |
| Defective HPRT1 disrupts guanine and hypoxanthine salvage | R-HSA-9734281 | 3.367122e-01 | 0.473 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 3.367122e-01 | 0.473 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 3.367122e-01 | 0.473 | 0 | 0 |
| Intracellular oxygen transport | R-HSA-8981607 | 3.367122e-01 | 0.473 | 0 | 0 |
| Diseases of Mismatch Repair (MMR) | R-HSA-5423599 | 3.367122e-01 | 0.473 | 0 | 0 |
| Histamine receptors | R-HSA-390650 | 3.367122e-01 | 0.473 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 3.370111e-01 | 0.472 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 3.370111e-01 | 0.472 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 3.375179e-01 | 0.472 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 3.375179e-01 | 0.472 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 3.375179e-01 | 0.472 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 3.382752e-01 | 0.471 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 3.383170e-01 | 0.471 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 3.427823e-01 | 0.465 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 3.435086e-01 | 0.464 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 3.435086e-01 | 0.464 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 3.471612e-01 | 0.459 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 3.474953e-01 | 0.459 | 0 | 0 |
| Signaling by activated point mutants of FGFR1 | R-HSA-1839122 | 3.487467e-01 | 0.457 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 3.487467e-01 | 0.457 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 3.487467e-01 | 0.457 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 3.562421e-01 | 0.448 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 3.564975e-01 | 0.448 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 3.565849e-01 | 0.448 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 3.573238e-01 | 0.447 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 3.595488e-01 | 0.444 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 3.595488e-01 | 0.444 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 3.595488e-01 | 0.444 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 3.597074e-01 | 0.444 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 3.597074e-01 | 0.444 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 3.597074e-01 | 0.444 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 3.597074e-01 | 0.444 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 3.597074e-01 | 0.444 | 1 | 1 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 3.597074e-01 | 0.444 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 3.611944e-01 | 0.442 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 3.611944e-01 | 0.442 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 3.613082e-01 | 0.442 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 3.661686e-01 | 0.436 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 3.709958e-01 | 0.431 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 3.732946e-01 | 0.428 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 3.735244e-01 | 0.428 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 3.756100e-01 | 0.425 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 3.756100e-01 | 0.425 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 3.756100e-01 | 0.425 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 3.780229e-01 | 0.422 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 3.780229e-01 | 0.422 | 0 | 0 |
| Interleukin-15 signaling | R-HSA-8983432 | 3.780229e-01 | 0.422 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 3.780229e-01 | 0.422 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 3.780229e-01 | 0.422 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 3.780229e-01 | 0.422 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 3.780229e-01 | 0.422 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 3.780229e-01 | 0.422 | 0 | 0 |
| Reversal of alkylation damage by DNA dioxygenases | R-HSA-73943 | 3.780229e-01 | 0.422 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 3.785571e-01 | 0.422 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 3.793598e-01 | 0.421 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 3.793643e-01 | 0.421 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 3.795892e-01 | 0.421 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 3.854256e-01 | 0.414 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 3.854256e-01 | 0.414 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 3.857689e-01 | 0.414 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 3.865657e-01 | 0.413 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 3.875677e-01 | 0.412 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 3.880387e-01 | 0.411 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 3.883010e-01 | 0.411 | 1 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 3.890076e-01 | 0.410 | 0 | 0 |
| Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | R-HSA-69200 | 3.890076e-01 | 0.410 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 3.890076e-01 | 0.410 | 0 | 0 |
| Defective LFNG causes SCDO3 | R-HSA-5083630 | 3.890076e-01 | 0.410 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 3.890076e-01 | 0.410 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 3.890076e-01 | 0.410 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 3.890076e-01 | 0.410 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 3.890076e-01 | 0.410 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 3.913497e-01 | 0.407 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 3.916648e-01 | 0.407 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 3.966000e-01 | 0.402 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 3.971775e-01 | 0.401 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 3.979273e-01 | 0.400 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 4.036859e-01 | 0.394 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 4.036859e-01 | 0.394 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 4.036859e-01 | 0.394 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 4.036859e-01 | 0.394 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 4.036859e-01 | 0.394 | 0 | 0 |
| Neurotoxicity of clostridium toxins | R-HSA-168799 | 4.036859e-01 | 0.394 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 4.067335e-01 | 0.391 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 4.067335e-01 | 0.391 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 4.076870e-01 | 0.390 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 4.106197e-01 | 0.387 | 1 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 4.110039e-01 | 0.386 | 1 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 4.110039e-01 | 0.386 | 1 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 4.135774e-01 | 0.383 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 4.161718e-01 | 0.381 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 4.161718e-01 | 0.381 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 4.161718e-01 | 0.381 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 4.161725e-01 | 0.381 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 4.189406e-01 | 0.378 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 4.236515e-01 | 0.373 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 4.253565e-01 | 0.371 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 4.321703e-01 | 0.364 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 4.321703e-01 | 0.364 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 4.342883e-01 | 0.362 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 4.342883e-01 | 0.362 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 4.342883e-01 | 0.362 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 4.342883e-01 | 0.362 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 4.347859e-01 | 0.362 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 4.347878e-01 | 0.362 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 4.367812e-01 | 0.360 | 0 | 0 |
| PTK6 Down-Regulation | R-HSA-8849472 | 4.371828e-01 | 0.359 | 0 | 0 |
| FGFR1c and Klotho ligand binding and activation | R-HSA-190374 | 4.371828e-01 | 0.359 | 0 | 0 |
| G2 Phase | R-HSA-68911 | 4.371828e-01 | 0.359 | 0 | 0 |
| PTK6 Regulates Proteins Involved in RNA Processing | R-HSA-8849468 | 4.371828e-01 | 0.359 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 4.371828e-01 | 0.359 | 0 | 0 |
| PTK6 Activates STAT3 | R-HSA-8849474 | 4.371828e-01 | 0.359 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 4.371828e-01 | 0.359 | 0 | 0 |
| Interleukin-36 pathway | R-HSA-9014826 | 4.371828e-01 | 0.359 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 4.371828e-01 | 0.359 | 0 | 0 |
| Co-inhibition by BTLA | R-HSA-9927353 | 4.371828e-01 | 0.359 | 0 | 0 |
| NrCAM interactions | R-HSA-447038 | 4.371828e-01 | 0.359 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 4.371828e-01 | 0.359 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 4.383300e-01 | 0.358 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 4.383300e-01 | 0.358 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 4.395344e-01 | 0.357 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 4.395344e-01 | 0.357 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 4.395503e-01 | 0.357 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 4.405204e-01 | 0.356 | 1 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 4.405204e-01 | 0.356 | 1 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 4.467457e-01 | 0.350 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 4.491522e-01 | 0.348 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 4.522446e-01 | 0.345 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 4.522446e-01 | 0.345 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 4.553131e-01 | 0.342 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 4.594872e-01 | 0.338 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 4.596523e-01 | 0.338 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 4.599484e-01 | 0.337 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 4.621054e-01 | 0.335 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 4.621054e-01 | 0.335 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 4.621054e-01 | 0.335 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 4.621054e-01 | 0.335 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 4.621054e-01 | 0.335 | 0 | 0 |
| Formation of the anterior neural plate | R-HSA-9823739 | 4.621054e-01 | 0.335 | 0 | 0 |
| DNA Damage Reversal | R-HSA-73942 | 4.621054e-01 | 0.335 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 4.643501e-01 | 0.333 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 4.678084e-01 | 0.330 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 4.700112e-01 | 0.328 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 4.700112e-01 | 0.328 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 4.700112e-01 | 0.328 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 4.713993e-01 | 0.327 | 1 | 1 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 4.815622e-01 | 0.317 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 4.815622e-01 | 0.317 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 4.815622e-01 | 0.317 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 4.815622e-01 | 0.317 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 4.815622e-01 | 0.317 | 0 | 0 |
| Loss-of-function mutations in DBT cause MSUD2 | R-HSA-9865113 | 4.815622e-01 | 0.317 | 0 | 0 |
| Loss-of-function mutations in DLD cause MSUD3/DLDD | R-HSA-9907570 | 4.815622e-01 | 0.317 | 0 | 0 |
| GLI proteins bind promoters of Hh responsive genes to promote transcription | R-HSA-5635851 | 4.815622e-01 | 0.317 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 4.815622e-01 | 0.317 | 0 | 0 |
| Cam-PDE 1 activation | R-HSA-111957 | 4.815622e-01 | 0.317 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 4.815622e-01 | 0.317 | 0 | 0 |
| Synthesis of PS | R-HSA-1483101 | 4.815622e-01 | 0.317 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 4.815622e-01 | 0.317 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 4.815622e-01 | 0.317 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 4.815622e-01 | 0.317 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 4.815622e-01 | 0.317 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 4.815622e-01 | 0.317 | 0 | 0 |
| Toxicity of botulinum toxin type E (botE) | R-HSA-5250992 | 4.815622e-01 | 0.317 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 4.815622e-01 | 0.317 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 4.823583e-01 | 0.317 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 4.853865e-01 | 0.314 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 4.853865e-01 | 0.314 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 4.853865e-01 | 0.314 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 4.853865e-01 | 0.314 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 4.853865e-01 | 0.314 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 4.864743e-01 | 0.313 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 4.875607e-01 | 0.312 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 4.875607e-01 | 0.312 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 4.875607e-01 | 0.312 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 4.885049e-01 | 0.311 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 4.885049e-01 | 0.311 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 4.885049e-01 | 0.311 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 4.885049e-01 | 0.311 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 4.886333e-01 | 0.311 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 4.886333e-01 | 0.311 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 4.886333e-01 | 0.311 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 4.993137e-01 | 0.302 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 5.018181e-01 | 0.299 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 5.088005e-01 | 0.293 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 5.088005e-01 | 0.293 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 5.088005e-01 | 0.293 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 5.099179e-01 | 0.292 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 5.131077e-01 | 0.290 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 5.143244e-01 | 0.289 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 5.143244e-01 | 0.289 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 5.143244e-01 | 0.289 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 5.143244e-01 | 0.289 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 5.159721e-01 | 0.287 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 5.219114e-01 | 0.282 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 5.219114e-01 | 0.282 | 0 | 0 |
| Signaling by LTK in cancer | R-HSA-9842640 | 5.224446e-01 | 0.282 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 5.224446e-01 | 0.282 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 5.224446e-01 | 0.282 | 0 | 0 |
| G2/M DNA replication checkpoint | R-HSA-69478 | 5.224446e-01 | 0.282 | 0 | 0 |
| Autointegration results in viral DNA circles | R-HSA-177539 | 5.224446e-01 | 0.282 | 0 | 0 |
| Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | R-HSA-9865125 | 5.224446e-01 | 0.282 | 0 | 0 |
| H139Hfs13* PPM1K causes a mild variant of MSUD | R-HSA-9912529 | 5.224446e-01 | 0.282 | 0 | 0 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 5.224446e-01 | 0.282 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 5.224446e-01 | 0.282 | 0 | 0 |
| Integration of viral DNA into host genomic DNA | R-HSA-175567 | 5.224446e-01 | 0.282 | 0 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 5.224446e-01 | 0.282 | 0 | 0 |
| VLDL assembly | R-HSA-8866423 | 5.224446e-01 | 0.282 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 5.225458e-01 | 0.282 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 5.286652e-01 | 0.277 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 5.286652e-01 | 0.277 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 5.312614e-01 | 0.275 | 1 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 5.319452e-01 | 0.274 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 5.319452e-01 | 0.274 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 5.386695e-01 | 0.269 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 5.386695e-01 | 0.269 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 5.391460e-01 | 0.268 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 5.391460e-01 | 0.268 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 5.391460e-01 | 0.268 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 5.391460e-01 | 0.268 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 5.391460e-01 | 0.268 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 5.454458e-01 | 0.263 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 5.466978e-01 | 0.262 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 5.474231e-01 | 0.262 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 5.480734e-01 | 0.261 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 5.480734e-01 | 0.261 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 5.480734e-01 | 0.261 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 5.551245e-01 | 0.256 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 5.551245e-01 | 0.256 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 5.551245e-01 | 0.256 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 5.551245e-01 | 0.256 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 5.560779e-01 | 0.255 | 0 | 0 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | 5.601054e-01 | 0.252 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 5.601054e-01 | 0.252 | 0 | 0 |
| Pre-NOTCH Processing in the Endoplasmic Reticulum | R-HSA-1912399 | 5.601054e-01 | 0.252 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 5.601054e-01 | 0.252 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 5.601054e-01 | 0.252 | 0 | 0 |
| NOSTRIN mediated eNOS trafficking | R-HSA-203641 | 5.601054e-01 | 0.252 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 5.601054e-01 | 0.252 | 0 | 0 |
| LDL remodeling | R-HSA-8964041 | 5.601054e-01 | 0.252 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 5.601054e-01 | 0.252 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 5.601054e-01 | 0.252 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | R-HSA-2892245 | 5.601054e-01 | 0.252 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 5.601054e-01 | 0.252 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 5.612246e-01 | 0.251 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 5.630753e-01 | 0.249 | 0 | 0 |
| FGFR1 ligand binding and activation | R-HSA-190242 | 5.630753e-01 | 0.249 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 5.630753e-01 | 0.249 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 5.630753e-01 | 0.249 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 5.630753e-01 | 0.249 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 5.630753e-01 | 0.249 | 0 | 0 |
| Nephron development | R-HSA-9831926 | 5.630753e-01 | 0.249 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 5.630753e-01 | 0.249 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 5.670037e-01 | 0.246 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 5.670037e-01 | 0.246 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 5.670037e-01 | 0.246 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 5.670037e-01 | 0.246 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 5.712604e-01 | 0.243 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 5.712604e-01 | 0.243 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 5.717348e-01 | 0.243 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 5.755134e-01 | 0.240 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 5.860987e-01 | 0.232 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 5.870631e-01 | 0.231 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 5.870631e-01 | 0.231 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 5.895532e-01 | 0.229 | 0 | 0 |
| phospho-PLA2 pathway | R-HSA-111995 | 5.947982e-01 | 0.226 | 0 | 0 |
| FGFR1b ligand binding and activation | R-HSA-190370 | 5.947982e-01 | 0.226 | 0 | 0 |
| Activated NTRK2 signals through PI3K | R-HSA-9028335 | 5.947982e-01 | 0.226 | 0 | 0 |
| MET receptor recycling | R-HSA-8875656 | 5.947982e-01 | 0.226 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 5.947982e-01 | 0.226 | 0 | 0 |
| Interleukin-9 signaling | R-HSA-8985947 | 5.947982e-01 | 0.226 | 0 | 0 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | 5.947982e-01 | 0.226 | 0 | 0 |
| Nucleotide salvage defects | R-HSA-9734207 | 5.947982e-01 | 0.226 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 5.947982e-01 | 0.226 | 0 | 0 |
| Interleukin-23 signaling | R-HSA-9020933 | 5.947982e-01 | 0.226 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 5.951399e-01 | 0.225 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 5.975385e-01 | 0.224 | 1 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 5.997846e-01 | 0.222 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 6.025204e-01 | 0.220 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 6.033341e-01 | 0.219 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 6.033341e-01 | 0.219 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.048687e-01 | 0.218 | 1 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 6.082103e-01 | 0.216 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 6.082103e-01 | 0.216 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 6.172869e-01 | 0.210 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 6.189376e-01 | 0.208 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 6.207681e-01 | 0.207 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 6.207681e-01 | 0.207 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 6.207681e-01 | 0.207 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 6.217467e-01 | 0.206 | 0 | 0 |
| Interleukin-21 signaling | R-HSA-9020958 | 6.267569e-01 | 0.203 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 6.267569e-01 | 0.203 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 6.267569e-01 | 0.203 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 6.267569e-01 | 0.203 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 6.267569e-01 | 0.203 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 6.267569e-01 | 0.203 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 6.267569e-01 | 0.203 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 6.267569e-01 | 0.203 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 6.267569e-01 | 0.203 | 0 | 0 |
| Regulation of NPAS4 gene transcription | R-HSA-9768777 | 6.267569e-01 | 0.203 | 0 | 0 |
| Toxicity of botulinum toxin type A (botA) | R-HSA-5250968 | 6.267569e-01 | 0.203 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 6.267569e-01 | 0.203 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 6.267569e-01 | 0.203 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 6.267569e-01 | 0.203 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 6.304545e-01 | 0.200 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 6.323594e-01 | 0.199 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 6.330916e-01 | 0.199 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 6.376446e-01 | 0.195 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 6.382669e-01 | 0.195 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 6.430420e-01 | 0.192 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 6.430420e-01 | 0.192 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 6.449023e-01 | 0.191 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 6.497061e-01 | 0.187 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 6.508292e-01 | 0.187 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 6.557111e-01 | 0.183 | 0 | 0 |
| Activation of Ca-permeable Kainate Receptor | R-HSA-451308 | 6.561967e-01 | 0.183 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 6.561967e-01 | 0.183 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 6.561967e-01 | 0.183 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 6.561967e-01 | 0.183 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 6.561967e-01 | 0.183 | 0 | 0 |
| DNA replication initiation | R-HSA-68952 | 6.561967e-01 | 0.183 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 6.561967e-01 | 0.183 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 6.561967e-01 | 0.183 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 6.561967e-01 | 0.183 | 0 | 0 |
| CASP4 inflammasome assembly | R-HSA-9948001 | 6.561967e-01 | 0.183 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 6.561967e-01 | 0.183 | 0 | 0 |
| MAPK3 (ERK1) activation | R-HSA-110056 | 6.561967e-01 | 0.183 | 0 | 0 |
| Tandem pore domain potassium channels | R-HSA-1296346 | 6.561967e-01 | 0.183 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 6.607153e-01 | 0.180 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 6.607153e-01 | 0.180 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 6.609860e-01 | 0.180 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 6.691072e-01 | 0.175 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 6.691072e-01 | 0.175 | 0 | 0 |
| Regulation of IFNA/IFNB signaling | R-HSA-912694 | 6.691072e-01 | 0.175 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy | R-HSA-9857377 | 6.691072e-01 | 0.175 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 6.691072e-01 | 0.175 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 6.697953e-01 | 0.174 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 6.697953e-01 | 0.174 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 6.801701e-01 | 0.167 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 6.833160e-01 | 0.165 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 6.833160e-01 | 0.165 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 6.833160e-01 | 0.165 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 6.833160e-01 | 0.165 | 0 | 0 |
| Ionotropic activity of kainate receptors | R-HSA-451306 | 6.833160e-01 | 0.165 | 0 | 0 |
| vRNP Assembly | R-HSA-192905 | 6.833160e-01 | 0.165 | 0 | 0 |
| Chylomicron assembly | R-HSA-8963888 | 6.833160e-01 | 0.165 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 6.833160e-01 | 0.165 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 6.833160e-01 | 0.165 | 0 | 0 |
| Suppression of apoptosis | R-HSA-9635465 | 6.833160e-01 | 0.165 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 6.833160e-01 | 0.165 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 6.833160e-01 | 0.165 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 6.850667e-01 | 0.164 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 6.850667e-01 | 0.164 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 6.854932e-01 | 0.164 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 6.876289e-01 | 0.163 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 6.876289e-01 | 0.163 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 6.876289e-01 | 0.163 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 6.876289e-01 | 0.163 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 6.876289e-01 | 0.163 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 6.876289e-01 | 0.163 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 6.992774e-01 | 0.155 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 7.003918e-01 | 0.155 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 7.052892e-01 | 0.152 | 0 | 0 |
| SHC-mediated cascade:FGFR1 | R-HSA-5654688 | 7.052892e-01 | 0.152 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 7.052892e-01 | 0.152 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 7.052892e-01 | 0.152 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 7.076190e-01 | 0.150 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 7.082977e-01 | 0.150 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 7.082977e-01 | 0.150 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 7.082977e-01 | 0.150 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 7.082977e-01 | 0.150 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 7.082977e-01 | 0.150 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 7.082977e-01 | 0.150 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 7.082977e-01 | 0.150 | 0 | 0 |
| Reduction of cytosolic Ca++ levels | R-HSA-418359 | 7.082977e-01 | 0.150 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 7.082977e-01 | 0.150 | 0 | 0 |
| POLB-Dependent Long Patch Base Excision Repair | R-HSA-110362 | 7.082977e-01 | 0.150 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 7.082977e-01 | 0.150 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 7.128486e-01 | 0.147 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 7.209484e-01 | 0.142 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 7.221086e-01 | 0.141 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 7.221086e-01 | 0.141 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 7.221086e-01 | 0.141 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 7.221086e-01 | 0.141 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 7.221086e-01 | 0.141 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 7.221086e-01 | 0.141 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 7.224825e-01 | 0.141 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 7.267874e-01 | 0.139 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 7.276915e-01 | 0.138 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 7.309605e-01 | 0.136 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 7.313100e-01 | 0.136 | 0 | 0 |
| Maple Syrup Urine Disease | R-HSA-9865114 | 7.313100e-01 | 0.136 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 7.313100e-01 | 0.136 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 7.313100e-01 | 0.136 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 7.313100e-01 | 0.136 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 7.313100e-01 | 0.136 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 7.313100e-01 | 0.136 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 7.313100e-01 | 0.136 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 7.313100e-01 | 0.136 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 7.313100e-01 | 0.136 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 7.313100e-01 | 0.136 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 7.313100e-01 | 0.136 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 7.313100e-01 | 0.136 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 7.313100e-01 | 0.136 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 7.313100e-01 | 0.136 | 0 | 0 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 7.313100e-01 | 0.136 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 7.313100e-01 | 0.136 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 7.313100e-01 | 0.136 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 7.313100e-01 | 0.136 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 7.366125e-01 | 0.133 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 7.374693e-01 | 0.132 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 7.376016e-01 | 0.132 | 0 | 0 |
| Diseases of branched-chain amino acid catabolism | R-HSA-9865118 | 7.381100e-01 | 0.132 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 7.395970e-01 | 0.131 | 1 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 7.399244e-01 | 0.131 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 7.399244e-01 | 0.131 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 7.399244e-01 | 0.131 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 7.408538e-01 | 0.130 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 7.408538e-01 | 0.130 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 7.408538e-01 | 0.130 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 7.524612e-01 | 0.124 | 0 | 0 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | R-HSA-9661069 | 7.525082e-01 | 0.123 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 7.525082e-01 | 0.123 | 0 | 0 |
| Microbial factors inhibit CASP4 activity | R-HSA-9956593 | 7.525082e-01 | 0.123 | 0 | 0 |
| FGFR1c ligand binding and activation | R-HSA-190373 | 7.525082e-01 | 0.123 | 0 | 0 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | R-HSA-9659787 | 7.525082e-01 | 0.123 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 7.525082e-01 | 0.123 | 0 | 0 |
| Diseases of nucleotide metabolism | R-HSA-9735804 | 7.525082e-01 | 0.123 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 7.525082e-01 | 0.123 | 0 | 0 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | R-HSA-5676594 | 7.525082e-01 | 0.123 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 7.525082e-01 | 0.123 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 7.525082e-01 | 0.123 | 0 | 0 |
| RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | R-HSA-8877330 | 7.525082e-01 | 0.123 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 7.525082e-01 | 0.123 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 7.525082e-01 | 0.123 | 0 | 0 |
| Replication of the SARS-CoV-1 genome | R-HSA-9682706 | 7.525082e-01 | 0.123 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 7.533176e-01 | 0.123 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 7.561253e-01 | 0.121 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 7.618266e-01 | 0.118 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 7.647222e-01 | 0.116 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 7.656545e-01 | 0.116 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 7.656545e-01 | 0.116 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 7.677571e-01 | 0.115 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 7.677571e-01 | 0.115 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 7.677571e-01 | 0.115 | 0 | 0 |
| BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | R-HSA-9859138 | 7.720351e-01 | 0.112 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 7.720351e-01 | 0.112 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 7.720351e-01 | 0.112 | 0 | 0 |
| Hydrolysis of LPC | R-HSA-1483115 | 7.720351e-01 | 0.112 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 7.720351e-01 | 0.112 | 0 | 0 |
| Non-canonical inflammasome activation | R-HSA-9686114 | 7.720351e-01 | 0.112 | 0 | 0 |
| Acyl chain remodeling of CL | R-HSA-1482798 | 7.720351e-01 | 0.112 | 0 | 0 |
| SARS-CoV-1 Genome Replication and Transcription | R-HSA-9679514 | 7.720351e-01 | 0.112 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 7.737686e-01 | 0.111 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 7.814550e-01 | 0.107 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 7.822588e-01 | 0.107 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 7.894168e-01 | 0.103 | 0 | 0 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | R-HSA-9673767 | 7.900224e-01 | 0.102 | 0 | 0 |
| Signaling by PDGFRA extracellular domain mutants | R-HSA-9673770 | 7.900224e-01 | 0.102 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 7.900224e-01 | 0.102 | 0 | 0 |
| RNA Polymerase III Chain Elongation | R-HSA-73780 | 7.900224e-01 | 0.102 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 7.900224e-01 | 0.102 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 7.900224e-01 | 0.102 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 7.900224e-01 | 0.102 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 7.916012e-01 | 0.101 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 7.933061e-01 | 0.101 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 7.944384e-01 | 0.100 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 7.944384e-01 | 0.100 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 7.944384e-01 | 0.100 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 7.944384e-01 | 0.100 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 8.028726e-01 | 0.095 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 8.042376e-01 | 0.095 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 8.065915e-01 | 0.093 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 8.065915e-01 | 0.093 | 0 | 0 |
| Phase 4 - resting membrane potential | R-HSA-5576886 | 8.065915e-01 | 0.093 | 0 | 0 |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | R-HSA-434316 | 8.065915e-01 | 0.093 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 8.065915e-01 | 0.093 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 8.065915e-01 | 0.093 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 8.065915e-01 | 0.093 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 8.067347e-01 | 0.093 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 8.067347e-01 | 0.093 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 8.080785e-01 | 0.093 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 8.094428e-01 | 0.092 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 8.094428e-01 | 0.092 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 8.168719e-01 | 0.088 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 8.183715e-01 | 0.087 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 8.192458e-01 | 0.087 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 8.192458e-01 | 0.087 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 8.192458e-01 | 0.087 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 8.210119e-01 | 0.086 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 8.218540e-01 | 0.085 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 8.218540e-01 | 0.085 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 8.218540e-01 | 0.085 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 8.218540e-01 | 0.085 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 8.218540e-01 | 0.085 | 0 | 0 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 8.218540e-01 | 0.085 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 8.218540e-01 | 0.085 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 8.218540e-01 | 0.085 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 8.232030e-01 | 0.084 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 8.253312e-01 | 0.083 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 8.253312e-01 | 0.083 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 8.293763e-01 | 0.081 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 8.293763e-01 | 0.081 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 8.305813e-01 | 0.081 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 8.359129e-01 | 0.078 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 8.359129e-01 | 0.078 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 8.359129e-01 | 0.078 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 8.359129e-01 | 0.078 | 0 | 0 |
| Choline catabolism | R-HSA-6798163 | 8.359129e-01 | 0.078 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 8.359129e-01 | 0.078 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 8.359129e-01 | 0.078 | 0 | 0 |
| Replication of the SARS-CoV-2 genome | R-HSA-9694686 | 8.359129e-01 | 0.078 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 8.375666e-01 | 0.077 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 8.397762e-01 | 0.076 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 8.397762e-01 | 0.076 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 8.397762e-01 | 0.076 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 8.397762e-01 | 0.076 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 8.415106e-01 | 0.075 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 8.428531e-01 | 0.074 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 8.479062e-01 | 0.072 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 8.487827e-01 | 0.071 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 8.488631e-01 | 0.071 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 8.488631e-01 | 0.071 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 8.488631e-01 | 0.071 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 8.488631e-01 | 0.071 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 8.488631e-01 | 0.071 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 8.495983e-01 | 0.071 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 8.495983e-01 | 0.071 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 8.495983e-01 | 0.071 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 8.583191e-01 | 0.066 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 8.588689e-01 | 0.066 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 8.588689e-01 | 0.066 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 8.588689e-01 | 0.066 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 8.588689e-01 | 0.066 | 0 | 0 |
| Defects in vitamin and cofactor metabolism | R-HSA-3296482 | 8.588689e-01 | 0.066 | 0 | 0 |
| Translation | R-HSA-72766 | 8.601091e-01 | 0.065 | 0 | 0 |
| Pre-NOTCH Processing in Golgi | R-HSA-1912420 | 8.607920e-01 | 0.065 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 8.607920e-01 | 0.065 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 8.607920e-01 | 0.065 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 8.607920e-01 | 0.065 | 0 | 0 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 8.607920e-01 | 0.065 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 8.607920e-01 | 0.065 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 8.607920e-01 | 0.065 | 0 | 0 |
| SARS-CoV-2 Genome Replication and Transcription | R-HSA-9694682 | 8.607920e-01 | 0.065 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 8.620327e-01 | 0.064 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 8.694373e-01 | 0.061 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 8.702562e-01 | 0.060 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 8.717800e-01 | 0.060 | 0 | 0 |
| Formation of ATP by chemiosmotic coupling | R-HSA-163210 | 8.717800e-01 | 0.060 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 8.717800e-01 | 0.060 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 8.717800e-01 | 0.060 | 0 | 0 |
| Acyl chain remodelling of PI | R-HSA-1482922 | 8.717800e-01 | 0.060 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 8.717800e-01 | 0.060 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 8.795658e-01 | 0.056 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 8.800558e-01 | 0.055 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 8.819013e-01 | 0.055 | 0 | 0 |
| Acyl chain remodelling of PG | R-HSA-1482925 | 8.819013e-01 | 0.055 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 8.819013e-01 | 0.055 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 8.836268e-01 | 0.054 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 8.909431e-01 | 0.050 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 8.912242e-01 | 0.050 | 0 | 0 |
| Molybdenum cofactor biosynthesis | R-HSA-947581 | 8.912242e-01 | 0.050 | 0 | 0 |
| Glutathione synthesis and recycling | R-HSA-174403 | 8.912242e-01 | 0.050 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 8.912242e-01 | 0.050 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 8.933148e-01 | 0.049 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 8.936635e-01 | 0.049 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 8.978301e-01 | 0.047 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 8.978301e-01 | 0.047 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 8.978301e-01 | 0.047 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 8.998116e-01 | 0.046 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 8.998116e-01 | 0.046 | 0 | 0 |
| Cholesterol biosynthesis via lathosterol | R-HSA-6807062 | 8.998116e-01 | 0.046 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 8.998116e-01 | 0.046 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 8.998116e-01 | 0.046 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 9.006172e-01 | 0.045 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 9.006172e-01 | 0.045 | 0 | 0 |
| Free fatty acids regulate insulin secretion | R-HSA-400451 | 9.077216e-01 | 0.042 | 0 | 0 |
| Synthesis of UDP-N-acetyl-glucosamine | R-HSA-446210 | 9.077216e-01 | 0.042 | 0 | 0 |
| Interleukin-20 family signaling | R-HSA-8854691 | 9.077216e-01 | 0.042 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 9.104042e-01 | 0.041 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 9.104042e-01 | 0.041 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 9.104042e-01 | 0.041 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 9.104042e-01 | 0.041 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 9.121026e-01 | 0.040 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.121026e-01 | 0.040 | 0 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 9.150075e-01 | 0.039 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 9.150075e-01 | 0.039 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 9.150075e-01 | 0.039 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 9.150075e-01 | 0.039 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 9.161330e-01 | 0.038 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 9.215163e-01 | 0.035 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 9.217185e-01 | 0.035 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 9.217185e-01 | 0.035 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 9.217185e-01 | 0.035 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 9.217185e-01 | 0.035 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 9.217185e-01 | 0.035 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 9.218706e-01 | 0.035 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.279000e-01 | 0.032 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 9.279000e-01 | 0.032 | 0 | 0 |
| Synthesis of IP2, IP, and Ins in the cytosol | R-HSA-1855183 | 9.279000e-01 | 0.032 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 9.279000e-01 | 0.032 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 9.279000e-01 | 0.032 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.293125e-01 | 0.032 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 9.313205e-01 | 0.031 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 9.313205e-01 | 0.031 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 9.335938e-01 | 0.030 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 9.335938e-01 | 0.030 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 9.335938e-01 | 0.030 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 9.335938e-01 | 0.030 | 0 | 0 |
| Synthesis of PE | R-HSA-1483213 | 9.335938e-01 | 0.030 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 9.335938e-01 | 0.030 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 9.357767e-01 | 0.029 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 9.357767e-01 | 0.029 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 9.388382e-01 | 0.027 | 0 | 0 |
| Pyrimidine salvage | R-HSA-73614 | 9.388382e-01 | 0.027 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 9.402083e-01 | 0.027 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 9.436687e-01 | 0.025 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 9.436687e-01 | 0.025 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 9.436687e-01 | 0.025 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 9.436687e-01 | 0.025 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 9.438794e-01 | 0.025 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.447811e-01 | 0.025 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 9.481180e-01 | 0.023 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.481180e-01 | 0.023 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 9.482040e-01 | 0.023 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.491659e-01 | 0.023 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 9.510030e-01 | 0.022 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 9.522161e-01 | 0.021 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 9.528317e-01 | 0.021 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.541576e-01 | 0.020 | 0 | 0 |
| Branched-chain amino acid catabolism | R-HSA-70895 | 9.542326e-01 | 0.020 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.546169e-01 | 0.020 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 9.559907e-01 | 0.020 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.559907e-01 | 0.020 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 9.565674e-01 | 0.019 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.568580e-01 | 0.019 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.571967e-01 | 0.019 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 9.593297e-01 | 0.018 | 0 | 0 |
| Diseases associated with glycosylation precursor biosynthesis | R-HSA-5609975 | 9.594673e-01 | 0.018 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.615452e-01 | 0.017 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 9.618175e-01 | 0.017 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 9.626695e-01 | 0.017 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 9.636555e-01 | 0.016 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.648452e-01 | 0.016 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.652266e-01 | 0.015 | 0 | 0 |
| Immune System | R-HSA-168256 | 9.656184e-01 | 0.015 | 1 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.656189e-01 | 0.015 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 9.656189e-01 | 0.015 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 9.656189e-01 | 0.015 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 9.656189e-01 | 0.015 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 9.656189e-01 | 0.015 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 9.656189e-01 | 0.015 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 9.656189e-01 | 0.015 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 9.667836e-01 | 0.015 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 9.683355e-01 | 0.014 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 9.697382e-01 | 0.013 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.708375e-01 | 0.013 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 9.708375e-01 | 0.013 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.710363e-01 | 0.013 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.717559e-01 | 0.012 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 9.719711e-01 | 0.012 | 0 | 0 |
| Lysine catabolism | R-HSA-71064 | 9.731420e-01 | 0.012 | 0 | 0 |
| Metabolism of folate and pterines | R-HSA-196757 | 9.731420e-01 | 0.012 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.739980e-01 | 0.011 | 0 | 0 |
| Purine salvage | R-HSA-74217 | 9.752645e-01 | 0.011 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 9.752645e-01 | 0.011 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 9.752902e-01 | 0.011 | 0 | 0 |
| Nucleotide salvage | R-HSA-8956321 | 9.770941e-01 | 0.010 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 9.770941e-01 | 0.010 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 9.772193e-01 | 0.010 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 9.785501e-01 | 0.009 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.786458e-01 | 0.009 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.790198e-01 | 0.009 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.804802e-01 | 0.009 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.806781e-01 | 0.008 | 0 | 0 |
| Aflatoxin activation and detoxification | R-HSA-5423646 | 9.806781e-01 | 0.008 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.814496e-01 | 0.008 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 9.814496e-01 | 0.008 | 0 | 0 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 9.822054e-01 | 0.008 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 9.827975e-01 | 0.008 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.838946e-01 | 0.007 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.841327e-01 | 0.007 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.849062e-01 | 0.007 | 0 | 0 |
| Pyrimidine catabolism | R-HSA-73621 | 9.849076e-01 | 0.007 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.849966e-01 | 0.007 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 9.861008e-01 | 0.006 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 9.861008e-01 | 0.006 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 9.870614e-01 | 0.006 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.871998e-01 | 0.006 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 9.872507e-01 | 0.006 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.876842e-01 | 0.005 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.878804e-01 | 0.005 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 9.886941e-01 | 0.005 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 9.887657e-01 | 0.005 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.891440e-01 | 0.005 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.900025e-01 | 0.004 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.907931e-01 | 0.004 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.908984e-01 | 0.004 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 9.913670e-01 | 0.004 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.921919e-01 | 0.003 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.922999e-01 | 0.003 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.931778e-01 | 0.003 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.935524e-01 | 0.003 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 9.936271e-01 | 0.003 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 9.943845e-01 | 0.002 | 0 | 0 |
| Disease | R-HSA-1643685 | 9.946280e-01 | 0.002 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 9.948288e-01 | 0.002 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.952379e-01 | 0.002 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.952379e-01 | 0.002 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.959617e-01 | 0.002 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 9.959617e-01 | 0.002 | 0 | 0 |
| Glutathione conjugation | R-HSA-156590 | 9.962813e-01 | 0.002 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.965756e-01 | 0.001 | 0 | 0 |
| Nicotinate metabolism | R-HSA-196807 | 9.979122e-01 | 0.001 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.980775e-01 | 0.001 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 9.981031e-01 | 0.001 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.981722e-01 | 0.001 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.982414e-01 | 0.001 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.984358e-01 | 0.001 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.984358e-01 | 0.001 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.984734e-01 | 0.001 | 1 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.984989e-01 | 0.001 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.984989e-01 | 0.001 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.985364e-01 | 0.001 | 0 | 0 |
| Purine catabolism | R-HSA-74259 | 9.986178e-01 | 0.001 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 9.989795e-01 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 9.989824e-01 | 0.000 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.992243e-01 | 0.000 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.993424e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.993473e-01 | 0.000 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.994886e-01 | 0.000 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.995895e-01 | 0.000 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.997120e-01 | 0.000 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.997186e-01 | 0.000 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.997368e-01 | 0.000 | 1 | 0 |
| FCGR activation | R-HSA-2029481 | 9.997931e-01 | 0.000 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.998003e-01 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 9.998391e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.998513e-01 | 0.000 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 9.998513e-01 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.998676e-01 | 0.000 | 1 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.998740e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.998840e-01 | 0.000 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 9.998840e-01 | 0.000 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 9.999051e-01 | 0.000 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.999166e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.999349e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.999533e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.999570e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.999604e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.999721e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.999847e-01 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 9.999858e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.999860e-01 | 0.000 | 0 | 0 |
| Sensory perception of sweet, bitter, and umami (glutamate) taste | R-HSA-9717207 | 9.999876e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999917e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999928e-01 | 0.000 | 0 | 0 |
| Nucleotide catabolism | R-HSA-8956319 | 9.999930e-01 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 9.999935e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.999936e-01 | 0.000 | 0 | 0 |
| Sensory perception of taste | R-HSA-9717189 | 9.999946e-01 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 9.999946e-01 | 0.000 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.999950e-01 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 9.999952e-01 | 0.000 | 1 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 9.999972e-01 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 9.999984e-01 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 9.999985e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.999991e-01 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 9.999992e-01 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 9.999994e-01 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 9.999995e-01 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 9.999995e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999998e-01 | 0.000 | 0 | 0 |
| Infection with Enterobacteria | R-HSA-9640148 | 1.000000e+00 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
