PHKG2
Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Motif clusters with count ≥ 10 are shown
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| substrate_uniprot | site | source | substrate_genes | site_seq |
|---|---|---|---|---|
| A0A2R8Y4L2 | S95 | Sugiyama | HNRNPA1L3 HNRNPA1P48 | RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED |
| A5A3E0 | S1068 | Sugiyama | POTEF A26C1B | SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________ |
| A5A3E0 | T949 | Sugiyama | POTEF A26C1B | TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM |
| O00488 | S93 | Sugiyama | ZNF593 ZT86 | STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP |
| O00571 | S71 | Sugiyama | DDX3X DBX DDX3 | GFyDKDSSGWsssKDKDAyssFGsRsDsRGKssFFsDRGsG |
| O14974 | S910 | Sugiyama | PPP1R12A MBS MYPT1 | yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST |
| O14980 | S1055 | Sugiyama | XPO1 CRM1 | LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____ |
| O15143 | S333 | Sugiyama | ARPC1B ARC41 | GGtAAGAGLDsLHKNsVsQIsVLsGGKAKCSQFCTTGMDGG |
| O15523 | S71 | Sugiyama | DDX3Y DBY | GFHDKDSSGWSCSKDKDAyssFGsRDSRGKPGYFSERGSGS |
| O43390 | T137 | Sugiyama | HNRNPR HNRPR | ESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS |
| O43390 | T141 | Sugiyama | HNRNPR HNRPR | GPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGVQP |
| O43707 | S423 | Sugiyama | ACTN4 | NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLKHRDyEt |
| O43852 | S44 | Sugiyama | CALU | KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL |
| O60220 | S94 | Sugiyama | TIMM8A DDP DDP1 TIM8A | SQFILNRLEQTQKSKPVFSEsLsD_________________ |
| O60506 | T134 | Sugiyama | SYNCRIP HNRPQ NSAP1 | DSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS |
| O60506 | T138 | Sugiyama | SYNCRIP HNRPQ NSAP1 | GPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGQQP |
| O60664 | S175 | Sugiyama | PLIN3 M6PRBP1 TIP47 | RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK |
| O60749 | S365 | Sugiyama | SNX2 TRG9 | AKSAAMLGNsEDHTALSRALsQLAEVEEKIDQLHQEQAFAD |
| O60814 | S37 | Sugiyama | H2BC12 H2BFT HIRIP1 HIST1H2BK | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| O60814 | S39 | Sugiyama | H2BC12 H2BFT HIRIP1 HIST1H2BK | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| O75347 | S103 | Sugiyama | TBCA | ENEKDLEEAEEyKEARLVLDsVKLEA_______________ |
| O75569 | S18 | Sugiyama | PRKRA PACT RAX HSD-14 HSD14 | ___MSQSRHRAEAPPLEREDsGtFsLGKMITAKPGKTPIQV |
| O75937 | S81 | Sugiyama | DNAJC8 SPF31 HSPC315 HSPC331 | VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE |
| O95373 | T968 | Sugiyama | IPO7 RANBP7 | IIDDEDNPVDEYQIFKAIFQtIQNRNPVWyQALTHGLNEEQ |
| O95678 | S162 | Sugiyama | KRT75 K6HF KB18 | IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA |
| O95757 | S586 | Sugiyama | HSPA4L APG1 HSPH3 OSP94 | DRLNQTLKKGKVKsIDLPIQssLCRQLGQDLLNsyIENEGK |
| O95757 | S587 | Sugiyama | HSPA4L APG1 HSPH3 OSP94 | RLNQTLKKGKVKsIDLPIQssLCRQLGQDLLNsyIENEGKM |
| P00338 | S105 | Sugiyama | LDHA PIG19 | VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV |
| P00338 | S161 | Sugiyama | LDHA PIG19 | DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH |
| P00338 | S167 | Sugiyama | LDHA PIG19 | AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG |
| P00558 | S174 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL |
| P00558 | S175 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN |
| P02538 | S176 | Sugiyama | KRT6A K6A KRT6D | IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT |
| P04075 | S17 | Sugiyama | ALDOA ALDA | ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst |
| P04075 | S336 | Sugiyama | ALDOA ALDA | GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs |
| P04075 | S356 | Sugiyama | ALDOA ALDA | sLACQGKytPsGQAGAAAsEsLFVsNHAy____________ |
| P04075 | S36 | Sugiyama | ALDOA ALDA | LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR |
| P04075 | S39 | Sugiyama | ALDOA ALDA | IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy |
| P04075 | S46 | Sugiyama | ALDOA ALDA | PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA |
| P04083 | S170 | Sugiyama | ANXA1 ANX1 LPC1 | RDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsE |
| P04259 | S176 | Sugiyama | KRT6B K6B KRTL1 | IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT |
| P04406 | S241 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV |
| P04406 | S321 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______ |
| P04406 | T237 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD |
| P04792 | S15 | Sugiyama | HSPB1 HSP27 HSP28 | ______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL |
| P04792 | S78 | Sugiyama | HSPB1 HSP27 HSP28 | LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs |
| P04792 | S82 | Sugiyama | HSPB1 HSP27 HSP28 | AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN |
| P05787 | S104 | Sugiyama | KRT8 CYK8 | IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS |
| P05787 | S410 | Sugiyama | KRT8 CYK8 | TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL |
| P06733 | S268 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | ASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyP |
| P06733 | S27 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL |
| P06733 | S349 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | AKAVNEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMV |
| P06733 | S353 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs |
| P06733 | S40 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK |
| P06733 | T205 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE |
| P06733 | Y270 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV |
| P06737 | S15 | SIGNOR | PYGL | ______MAKPLTDQEKRRQIsIRGIVGVENVAELKKSFNRH |
| P06748 | S242 | Sugiyama | NPM1 NPM | sKGQEsFKKQEKtPKtPKGPssVEDIKAKMQAsIEKGGsLP |
| P06748 | S43 | Sugiyama | NPM1 NPM | LKADKDyHFKVDNDENEHQLsLRTVsLGAGAKDELHIVEAE |
| P07195 | S106 | Sugiyama | LDHB | VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV |
| P07195 | S162 | Sugiyama | LDHB | DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH |
| P07195 | S168 | Sugiyama | LDHB | TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG |
| P07195 | S303 | Sugiyama | LDHB | GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt |
| P07195 | T302 | Sugiyama | LDHB | YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD |
| P07195 | T323 | Sugiyama | LDHB | sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________ |
| P07237 | S427 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP |
| P07355 | S184 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK |
| P07437 | S75 | Sugiyama | TUBB TUBB5 OK/SW-cl.56 | tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs |
| P07711 | S329 | Sugiyama | CTSL CTSL1 | GGyVKMAKDRRNHCGIAsAAsyPtV________________ |
| P07737 | S30 | Sugiyama | PFN1 | NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV |
| P07737 | S85 | Sugiyama | PFN1 | tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK |
| P07737 | T65 | Sugiyama | PFN1 | PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs |
| P07737 | Y60 | Sugiyama | PFN1 | FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ |
| P07814 | S335 | Sugiyama | EPRS1 EPRS GLNS PARS QARS QPRS PIG32 | PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt |
| P07864 | S161 | Sugiyama | LDHC LDH3 LDHX | DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH |
| P07864 | S167 | Sugiyama | LDHC LDH3 LDHX | VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG |
| P07900 | S165 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK |
| P07900 | S169 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | TVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILH |
| P07900 | S399 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK |
| P07900 | S53 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG |
| P07900 | S623 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII |
| P07900 | T109 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | LtIVDtGIGMTKADLINNLGtIAKSGtKAFMEALQAGADIS |
| P07900 | T317 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF |
| P08238 | S160 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK |
| P08238 | S164 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | VVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILH |
| P08238 | S391 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK |
| P08238 | S45 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL |
| P08238 | S462 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs |
| P08238 | S468 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG |
| P08238 | S48 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG |
| P08238 | T104 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | LtLVDtGIGMtKADLINNLGtIAKSGtKAFMEALQAGADIS |
| P08238 | T309 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF |
| P08238 | Y457 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK |
| P08670 | S325 | Sugiyama | VIM | NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR |
| P08708 | S89 | Sugiyama | RPS17 RPS17L | ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL |
| P08729 | S104 | Sugiyama | KRT7 SCL | LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT |
| P08758 | T10 | Sugiyama | ANXA5 ANX5 ENX2 PP4 | ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG |
| P09234 | S48 | Sugiyama | SNRPC | RKHKENVKDYYQKWMEEQAQsLIDKTTAAFQQGKIPPTPFS |
| P09382 | T58 | Sugiyama | LGALS1 | DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF |
| P09651 | S95 | Sugiyama | HNRNPA1 HNRPA1 | RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED |
| P09874 | S185 | Sugiyama | PARP1 ADPRT PPOL | KNREELGFRPEYsAsQLKGFsLLAtEDKEALKKQLPGVKSE |
| P09972 | S17 | Sugiyama | ALDOC ALDC | ____MPHSYPALSAEQKKELsDIALRIVAPGKGILAADEsV |
| P0CG38 | S1068 | Sugiyama | POTEI | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0CG39 | S1031 | Sugiyama | POTEJ | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0CG47 | S57 | Sugiyama | UBB | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM |
| P0CG48 | S57 | Sugiyama | UBC | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM |
| P0DPH7 | S48 | Sugiyama | TUBA3C TUBA2 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P0DPH7 | T334 | Sugiyama | TUBA3C TUBA2 | ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG |
| P10412 | S36 | Sugiyama | H1-4 H1F4 HIST1H1E | EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG |
| P10412 | S55 | Sugiyama | H1-4 H1F4 HIST1H1E | AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK |
| P10809 | S453 | Sugiyama | HSPD1 HSP60 | EEGIVLGGGCALLRCIPALDsLtPANEDQKIGIEIIKRTLK |
| P10809 | S488 | Sugiyama | HSPD1 HSP60 | IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG |
| P10809 | S67 | Sugiyama | HSPD1 HSP60 | LADAVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLK |
| P11142 | S340 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN |
| P11142 | S40 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P11142 | T66 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD |
| P11217 | S15 | SIGNOR | PYGM | ______MsRPLSDQEKRKQIsVRGLAGVENVtELKKNFNRH |
| P11532 | S3623 | Sugiyama | DMD | EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE |
| P11586 | S129 | Sugiyama | MTHFD1 MTHFC MTHFD | INTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCtP |
| P12004 | S152 | Sugiyama | PCNA | EySCVVKMPSGEFARICRDLsHIGDAVVIsCAKDGVKFSAs |
| P12004 | S161 | Sugiyama | PCNA | SGEFARICRDLsHIGDAVVIsCAKDGVKFSAsGELGNGNIK |
| P12035 | S211 | Sugiyama | KRT3 | IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN |
| P12814 | S404 | Sugiyama | ACTN1 | NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLRQKDyEt |
| P13073 | S74 | Sugiyama | COX4I1 COX4 | HLSASQKALKEKEKASWssLsMDEKVELYRIKFKEsFAEMN |
| P13489 | S290 | Sugiyama | RNH1 PRI RNH | AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE |
| P13639 | S23 | Sugiyama | EEF2 EF2 | NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA |
| P13639 | S38 | Sugiyama | EEF2 EF2 | NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD |
| P13639 | S593 | Sugiyama | EEF2 EF2 | SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL |
| P13639 | S732 | Sugiyama | EEF2 EF2 | DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP |
| P13639 | T5 | Sugiyama | EEF2 EF2 | ________________MVNFtVDQIRAIMDKKANIRNMsVI |
| P13647 | S181 | Sugiyama | KRT5 | IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT |
| P13667 | S126 | Sugiyama | PDIA4 ERP70 ERP72 | NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG |
| P13667 | S379 | Sugiyama | PDIA4 ERP70 ERP72 | QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH |
| P13667 | Y565 | Sugiyama | PDIA4 ERP70 ERP72 | DVLIEFYAPWCGHCKQLEPVyNsLAKKYKGQKGLVIAKMDA |
| P14314 | S126 | Sugiyama | PRKCSH G19P1 | yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE |
| P14314 | S478 | Sugiyama | PRKCSH G19P1 | DKFSAMKyEQGtGCWQGPNRstTVRLLCGKEtMVtStTEPS |
| P14618 | S202 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs |
| P14618 | S77 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | sVEtLKEMIKsGMNVARLNFsHGtHEyHAEtIKNVRtAtEs |
| P14618 | T50 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN |
| P14618 | T87 | Sugiyama | PKM OIP3 PK2 PK3 PKM2 | sGMNVARLNFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRP |
| P14625 | S106 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL |
| P14625 | S109 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN |
| P14625 | S172 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI |
| P14625 | S64 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR |
| P14625 | S674 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | WsGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLI |
| P14649 | S87 | Sugiyama | MYL6B MLC1SA | EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK |
| P14854 | S52 | Sugiyama | COX6B1 COX6B | QNyLDFHRCQKAMTAKGGDIsVCEWyQRVYQsLCPtsWVTD |
| P15311 | S539 | Sugiyama | EZR VIL2 | TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR |
| P15531 | S122 | Sugiyama | NME1 NDPKA NM23 | GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy |
| P15735 | S175 | Sugiyama | PHKG2 | KPENILLDDNMQIRLSDFGFsCHLEPGEKLRELCGTPGYLA |
| P15735 | S253 | Sugiyama | PHKG2 | FWHRRQILMLRMIMEGQYQFsSPEWDDRSSTVKDLIsRLLQ |
| P15735 | S297 | Sugiyama | PHKG2 | EARLTAEQALQHPFFERCEGsQPWNLTPRQRFRVAVWTVLA |
| P15735 | Y341 | Sugiyama | PHKG2 | VALSTHRVRPLTKNALLRDPyALRsVRHLIDNCAFRLYGHW |
| P15880 | S206 | Sugiyama | RPS2 RPS4 | GRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDCytsA |
| P16070 | S71 | Sugiyama | CD44 LHR MDU2 MDU3 MIC4 | DLCKAFNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRI |
| P16402 | S37 | Sugiyama | H1-3 H1F3 HIST1H1D | KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG |
| P16402 | S56 | Sugiyama | H1-3 H1F3 HIST1H1D | AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK |
| P16403 | S36 | Sugiyama | H1-2 H1F2 HIST1H1C | EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG |
| P16403 | S55 | Sugiyama | H1-2 H1F2 HIST1H1C | AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK |
| P17066 | S42 | Sugiyama | HSPA6 HSP70B' | VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA |
| P17987 | S35 | Sugiyama | TCP1 CCT1 CCTA | EtIRsQNVMAAAsIANIVKssLGPVGLDKMLVDDIGDVTIT |
| P17987 | S374 | Sugiyama | TCP1 CCT1 CCTA | ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD |
| P18615 | S135 | Sugiyama | NELFE RD RDBP | sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG |
| P18621 | S5 | Sugiyama | RPL17 | ________________MVRysLDPENPtKsCKSRGSNLRVH |
| P18621 | T79 | Sugiyama | RPL17 | PFRRYNGGVGRCAQAKQWGWtQGRWPKKSAEFLLHMLKNAE |
| P18621 | Y4 | Sugiyama | RPL17 | _________________MVRysLDPENPtKsCKSRGSNLRV |
| P18669 | S14 | Sugiyama | PGAM1 PGAMA CDABP0006 | _______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG |
| P18669 | S155 | Sugiyama | PGAM1 PGAMA CDABP0006 | NIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQI |
| P18669 | T159 | Sugiyama | PGAM1 PGAMA CDABP0006 | DRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQIKEGK |
| P19338 | S458 | Sugiyama | NCL | TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN |
| P19338 | S460 | Sugiyama | NCL | ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST |
| P19338 | Y462 | Sugiyama | NCL | AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs |
| P20618 | S162 | Sugiyama | PSMB1 PSC5 | DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG |
| P20839 | T159 | Sugiyama | IMPDH1 IMPD1 | FSGIPITETGTMGSKLVGIVtsRDIDFLAEKDHTTLLSEVM |
| P22090 | S204 | Sugiyama | RPS4Y1 RPS4Y PRO2646 | IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN |
| P22626 | S189 | Sugiyama | HNRNPA2B1 HNRPA2B1 | IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF |
| P23246 | S283 | Sugiyama | SFPQ PSF | GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN |
| P23381 | S357 | Sugiyama | WARS1 IFI53 WARS WRS | STFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAF |
| P23381 | S358 | Sugiyama | WARS1 IFI53 WARS WRS | TFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFs |
| P23396 | S35 | Sugiyama | RPS3 OK/SW-cl.26 | GIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATRT |
| P23526 | S183 | Sugiyama | AHCY SAHH | NLyKMMANGILKVPAINVNDsVtKsKFDNLyGCRESLIDGI |
| P23588 | S122 | Sugiyama | EIF4B | NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA |
| P24752 | S218 | Sugiyama | ACAT1 ACAT MAT | ENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPV |
| P25398 | S107 | Sugiyama | RPS12 | EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy |
| P25705 | S76 | Sugiyama | ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM | EERILGADtsVDLEETGRVLsIGDGIARVHGLRNVQAEEMV |
| P25786 | S211 | Sugiyama | PSMA1 HC2 NU PROS30 PSC2 | GLRALRETLPAEQDLttKNVsIGIVGKDLEFTIyDDDDVsP |
| P25786 | T11 | Sugiyama | PSMA1 HC2 NU PROS30 PSC2 | __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ |
| P26038 | S527 | Sugiyama | MSN | ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE |
| P26038 | S576 | Sugiyama | MSN | YKtLRQIRQGNTKQRIDEFEsM___________________ |
| P26373 | S181 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE |
| P26373 | S77 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs |
| P26373 | S97 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL |
| P26373 | T148 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV |
| P26373 | T151 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE |
| P26373 | T24 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | SRNGMVLKPHFHKDWQRRVAtWFNQPARKIRRRKARQAKAR |
| P26639 | S522 | Sugiyama | TARS1 TARS | PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP |
| P27348 | S45 | Sugiyama | YWHAQ | CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI |
| P27695 | S66 | Sugiyama | APEX1 APE APE1 APEX APX HAP1 REF1 | EDPPDQKtsPsGKPAtLKICsWNVDGLRAWIKKKGLDWVKE |
| P27797 | S52 | Sugiyama | CALR CRTC | GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA |
| P27797 | T34 | Sugiyama | CALR CRTC | LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG |
| P27824 | S362 | Sugiyama | CANX | WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK |
| P29144 | S93 | Sugiyama | TPP2 | SGDVNTATEVEPKDGEIVGLsGRVLKIPASWTNPSGKYHIG |
| P29401 | S305 | Sugiyama | TKT | LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL |
| P29401 | S308 | Sugiyama | TKT | PPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQALAKL |
| P29401 | S439 | Sugiyama | TKT | VSIGEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVE |
| P29692 | S44 | Sugiyama | EEF1D EF1D | RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs |
| P29692 | S60 | Sugiyama | EEF1D EF1D | ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL |
| P29692 | S86 | Sugiyama | EEF1D EF1D | GPGAssGtsGDHGELVVRIAsLEVENQsLRGVVQELQQAIs |
| P30048 | S199 | Sugiyama | PRDX3 AOP1 | SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF |
| P30050 | S138 | Sugiyama | RPL12 | HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG |
| P30050 | S26 | Sugiyama | RPL12 | DPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLsPKKVGDDI |
| P30084 | S107 | Sugiyama | ECHS1 | LTGGDKAFAAGADIKEMQNLsFQDCySSKFLKHWDHLTQVK |
| P30086 | S52 | Sugiyama | PEBP1 PBP PEBP | AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD |
| P30086 | S54 | Sugiyama | PEBP1 PBP PEBP | VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP |
| P30086 | T51 | Sugiyama | PEBP1 PBP PEBP | GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP |
| P30101 | T485 | Sugiyama | PDIA3 ERP57 ERP60 GRP58 | KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL |
| P31327 | S808 | Sugiyama | CPS1 | IGSSMKsVGEVMAIGRTFEEsFQKALRMCHPsIEGFTPRLP |
| P31327 | S898 | Sugiyama | CPS1 | LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS |
| P31939 | S202 | Sugiyama | ATIC PURH OK/SW-cl.86 | tAQyDEAISDyFRKQYSKGVsQMPLRyGMNPHQtPAQLytL |
| P31946 | S47 | Sugiyama | YWHAB | AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI |
| P31947 | S45 | Sugiyama | SFN HME1 | FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI |
| P31949 | T33 | Sugiyama | S100A11 MLN70 S100C | CIESLIAVFQKYAGKDGyNytLsKtEFLsFMNTELAAFTKN |
| P32119 | S151 | Sugiyama | PRDX2 NKEFB TDPX1 | IIDGKGVLRQItVNDLPVGRsVDEALRLVQAFQYTDEHGEV |
| P32119 | T142 | Sugiyama | PRDX2 NKEFB TDPX1 | EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF |
| P33176 | S717 | Sugiyama | KIF5B KNS KNS1 | VKQAVEQQIQSHRETHQKQIssLRDEVEAKAKLITDLQDQN |
| P33176 | S950 | Sugiyama | KIF5B KNS KNS1 | PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______ |
| P33527 | S915 | Sugiyama | ABCC1 MRP MRP1 | QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ |
| P34931 | S42 | Sugiyama | HSPA1L | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P34932 | S363 | Sugiyama | HSPA4 APG2 HSPH2 | GATRIPAVKEKISKFFGKELsttLNADEAVTRGCALQCAIL |
| P35579 | S1713 | Sugiyama | MYH9 | ERAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQ |
| P35908 | S191 | Sugiyama | KRT2 KRT2A KRT2E | IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE |
| P36578 | S55 | Sugiyama | RPL4 RPL1 | DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR |
| P36578 | S66 | Sugiyama | RPL4 RPL1 | KNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHR |
| P36578 | T62 | Sugiyama | RPL4 RPL1 | TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG |
| P37108 | S25 | Sugiyama | SRP14 | EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt |
| P37802 | S163 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG |
| P37802 | S185 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______ |
| P37837 | S13 | Sugiyama | TALDO1 TAL TALDO TALDOR | ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA |
| P38606 | S384 | Sugiyama | ATP6V1A ATP6A1 ATP6V1A1 VPP2 | RLAEMPADSGYPAyLGARLAsFYERAGRVKCLGNPEREGSV |
| P38646 | S212 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL |
| P38646 | S550 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | VHVSAKDKGTGREQQIVIQssGGLsKDDIENMVKNAEKYAE |
| P38646 | S89 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA |
| P38646 | T116 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD |
| P38646 | T398 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA |
| P39019 | S59 | Sugiyama | RPS19 | LAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsMTKIY |
| P39019 | Y54 | Sugiyama | RPS19 | VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs |
| P39023 | S13 | Sugiyama | RPL3 OK/SW-cl.32 | ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP |
| P39023 | S265 | Sugiyama | RPL3 OK/SW-cl.32 | HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY |
| P40227 | S49 | Sugiyama | CCT6A CCT6 CCTZ | GLQDVLRTNLGPKGTMKMLVsGAGDIKLTKDGNVLLHEMQI |
| P41091 | S282 | Sugiyama | EIF2S3 EIF2G | FDVNKPGCEVDDLKGGVAGGsILKGVLKVGQEIEVRPGIVS |
| P42677 | S78 | Sugiyama | RPS27 MPS1 | GCSTVLCQPTGGKARLtEGCsFRRKQH______________ |
| P43034 | S152 | Sugiyama | PAFAH1B1 LIS1 MDCR MDS PAFAHA | IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM |
| P43243 | S188 | Sugiyama | MATR3 KIAA0723 | EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs |
| P43243 | S195 | Sugiyama | MATR3 KIAA0723 | RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD |
| P43487 | S60 | Sugiyama | RANBP1 | TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH |
| P46060 | S24 | Sugiyama | RANGAP1 KIAA1835 SD | EDIAKLAETLAKTQVAGGQLsFKGKSLKLNTAEDAKDVIKE |
| P46776 | S68 | Sugiyama | RPL27A | yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV |
| P46777 | S172 | Sugiyama | RPL5 MSTP030 | RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA |
| P46777 | S176 | Sugiyama | RPL5 MSTP030 | GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR |
| P46777 | S224 | Sugiyama | RPL5 MSTP030 | VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH |
| P46779 | S26 | Sugiyama | RPL28 | QWMVVRNCssFLIKRNKQTYsTEPNNLKARNsFRYNGLIHR |
| P47712 | S729 | Sugiyama | PLA2G4A CPLA2 PLA2G4 | KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA |
| P47914 | S142 | Sugiyama | RPL29 | KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___ |
| P48637 | S276 | Sugiyama | GSS | VDGQEIAVVYFRDGYMPRQYsLQNWEARLLLERSHAAKCPD |
| P48643 | S270 | Sugiyama | CCT5 CCTE KIAA0098 | ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ |
| P48668 | S176 | Sugiyama | KRT6C KRT6E | IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT |
| P48741 | S42 | Sugiyama | HSPA7 HSP70B | VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA |
| P49321 | S659 | Sugiyama | NASP | IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst |
| P49327 | T2215 | Sugiyama | FASN FAS | DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN |
| P49419 | S84 | Sugiyama | ALDH7A1 ATQ1 | EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD |
| P49588 | S775 | Sugiyama | AARS1 AARS | VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI |
| P50402 | T30 | Sugiyama | EMD EDMD STA | tELttLLRRyNIPHGPVVGstRRLyEKKIFEyEtQRRRLsP |
| P50502 | S181 | Sugiyama | ST13 AAG2 FAM10A1 HIP SNC6 | LQKPNAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA |
| P50990 | S23 | Sugiyama | CCT8 C21orf112 CCTQ KIAA0002 | LHVPKAPGFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTT |
| P50991 | S51 | Sugiyama | CCT4 CCTD SRB | AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt |
| P51116 | S601 | Sugiyama | FXR2 FMR1L2 | RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ |
| P52742 | S308 | Sugiyama | ZNF135 ZNF61 ZNF78L1 | HQRTHTGEKPYECSECGKSFsFRSSFSQHERTHTGEKPYEC |
| P52907 | S215 | Sugiyama | CAPZA1 | QVHYYEDGNVQLVSHKDVQDsLtVsNEAQtAKEFIKIIENA |
| P53396 | S455 | Sugiyama | ACLY | ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP |
| P53999 | S118 | Sugiyama | SUB1 PC4 RPO2TC1 | PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________ |
| P53999 | S56 | Sugiyama | SUB1 PC4 RPO2TC1 | PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD |
| P54652 | S41 | Sugiyama | HSPA2 | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P55735 | S184 | Sugiyama | SEC13 D3S1231E SEC13A SEC13L1 SEC13R | PGsLIDHPSGQKPNYIKRFAsGGCDNLIKLWKEEEDGQWKE |
| P55854 | S27 | Sugiyama | SUMO3 SMT3A SMT3H1 | KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC |
| P57053 | S37 | Sugiyama | H2BC12L H2BFS H2BS1 | KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| P57053 | S39 | Sugiyama | H2BC12L H2BFS H2BS1 | VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| P57721 | S59 | Sugiyama | PCBP3 PCBP3-OT1 PCBP3OT | EGGLNVTLTIRLLMHGKEVGsIIGKKGETVKKMREESGARI |
| P57723 | S31 | Sugiyama | PCBP4 | EPELSITLTLRMLMHGKEVGsIIGKKGETVKRIREQSSARI |
| P58876 | S37 | Sugiyama | H2BC5 H2BFB HIRIP2 HIST1H2BD | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| P58876 | S39 | Sugiyama | H2BC5 H2BFB HIRIP2 HIST1H2BD | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| P60174 | S212 | Sugiyama | TPI1 TPI | WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV |
| P60174 | S97 | Sugiyama | TPI1 TPI | GEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELIGQKVAHA |
| P60174 | T217 | Sugiyama | TPI1 TPI | VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL |
| P60228 | S442 | Sugiyama | EIF3E EIF3S6 INT6 | IEKKLNQNSRSEAPNWAtQDsGFy_________________ |
| P60660 | S30 | Sugiyama | MYL6 | AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK |
| P60709 | S199 | Sugiyama | ACTB | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P60709 | S323 | Sugiyama | ACTB | ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG |
| P60709 | S368 | Sugiyama | ACTB | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P60709 | S52 | Sugiyama | ACTB | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P60709 | S60 | Sugiyama | ACTB | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P60709 | T249 | Sugiyama | ACTB | tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM |
| P60709 | T304 | Sugiyama | ACTB | KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst |
| P60709 | T318 | Sugiyama | ACTB | VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs |
| P60709 | T324 | Sugiyama | ACTB | tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs |
| P60709 | Y53 | Sugiyama | ACTB | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P61081 | T176 | Sugiyama | UBE2M UBC12 | NRRLFEQNVQRSMRGGyIGstyFERCLK_____________ |
| P61247 | S236 | Sugiyama | RPS3A FTE1 MFTL | KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy |
| P61247 | S238 | Sugiyama | RPS3A FTE1 MFTL | LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP |
| P61254 | S31 | Sugiyama | RPL26 | RsKNRKRHFNAPsHIRRKIMssPLSKELRQKYNVRSMPIRK |
| P61254 | T8 | Sugiyama | RPL26 | _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK |
| P61313 | S100 | Sugiyama | RPL15 EC45 TCBAP0781 | tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW |
| P61313 | S97 | Sugiyama | RPL15 EC45 TCBAP0781 | KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN |
| P61353 | S86 | Sugiyama | RPL27 | SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL |
| P61604 | S64 | Sugiyama | HSPE1 | AtVVAVGsGsKGKGGEIQPVsVKVGDKVLLPEyGGtKVVLD |
| P61769 | S75 | Sugiyama | B2M CDABP0092 HDCMA22P | IEVDLLKNGERIEKVEHsDLsFsKDWSFYLLYYTEFTPTEK |
| P61956 | S28 | Sugiyama | SUMO2 SMT3B SMT3H2 | EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC |
| P61978 | S401 | Sugiyama | HNRNPK HNRPK | GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI |
| P61978 | S75 | Sugiyama | HNRNPK HNRPK | GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE |
| P61981 | S46 | Sugiyama | YWHAG | AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI |
| P62241 | S115 | Sugiyama | RPS8 OK/SW-cl.83 | TLVKNCIVLIDStPYRQWyEsHyALPLGRKKGAKLtPEEEE |
| P62241 | S160 | Sugiyama | RPS8 OK/SW-cl.83 | KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG |
| P62249 | S9 | Sugiyama | RPS16 | ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN |
| P62258 | S148 | Sugiyama | YWHAE | YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP |
| P62258 | S46 | Sugiyama | YWHAE | SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI |
| P62263 | S139 | Sugiyama | RPS14 PRO2640 | LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________ |
| P62266 | S45 | Sugiyama | RPS23 | KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA |
| P62269 | S96 | Sugiyama | RPS18 D6S218E | QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK |
| P62277 | S12 | Sugiyama | RPS13 | _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD |
| P62277 | S14 | Sugiyama | RPS13 | _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK |
| P62280 | T15 | Sugiyama | RPS11 | ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR |
| P62424 | T84 | Sugiyama | RPL7A SURF-3 SURF3 | QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP |
| P62701 | S204 | Sugiyama | RPS4X CCG2 RPS4 SCAR | tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN |
| P62736 | S325 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG |
| P62736 | S54 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P62736 | S62 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P62736 | T251 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM |
| P62736 | T320 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS |
| P62736 | T326 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS |
| P62736 | Y55 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P62807 | S37 | Sugiyama | H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI | KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss |
| P62807 | S39 | Sugiyama | H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI | VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA |
| P62826 | T66 | Sugiyama | RAN ARA24 OK/SW-cl.81 | EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA |
| P62851 | S74 | Sugiyama | RPS25 | tyDKLCKEVPNYKLItPAVVsERLKIRGSLARAALQELLsK |
| P62899 | S15 | Sugiyama | RPL31 | ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG |
| P62899 | T26 | Sugiyama | RPL31 | KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL |
| P62906 | S64 | Sugiyama | RPL10A NEDD6 | QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH |
| P62917 | S130 | Sugiyama | RPL8 | GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL |
| P62917 | S138 | Sugiyama | RPL8 | EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI |
| P62917 | S14 | Sugiyama | RPL8 | _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF |
| P62917 | Y133 | Sugiyama | RPL8 | VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG |
| P62937 | T157 | Sugiyama | PPIA CYPA | NIVEAMERFGsRNGKTSKKItIADCGQLE____________ |
| P62942 | S68 | Sugiyama | FKBP1A FKBP1 FKBP12 | KFMLGKQEVIRGWEEGVAQMsVGQRAKLTISPDYAYGATGH |
| P62942 | T7 | Sugiyama | FKBP1A FKBP1 FKBP12 | ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy |
| P62979 | S134 | Sugiyama | RPS27A UBA80 UBCEP1 | IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE |
| P62979 | S57 | Sugiyama | RPS27A UBA80 UBCEP1 | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA |
| P62987 | S57 | Sugiyama | UBA52 UBCEP2 | PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI |
| P63104 | S28 | Sugiyama | YWHAZ | QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy |
| P63104 | S45 | Sugiyama | YWHAZ | CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI |
| P63167 | S21 | Sugiyama | DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 | MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH |
| P63220 | S31 | Sugiyama | RPS21 | LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK |
| P63220 | S68 | Sugiyama | RPS21 | GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____ |
| P63261 | S199 | Sugiyama | ACTG1 ACTG | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P63261 | S323 | Sugiyama | ACTG1 ACTG | ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG |
| P63261 | S368 | Sugiyama | ACTG1 ACTG | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P63261 | S52 | Sugiyama | ACTG1 ACTG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P63261 | S60 | Sugiyama | ACTG1 ACTG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P63261 | T249 | Sugiyama | ACTG1 ACTG | tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM |
| P63261 | T304 | Sugiyama | ACTG1 ACTG | KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst |
| P63261 | T318 | Sugiyama | ACTG1 ACTG | VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs |
| P63261 | T324 | Sugiyama | ACTG1 ACTG | tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs |
| P63261 | Y53 | Sugiyama | ACTG1 ACTG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P63267 | S324 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG |
| P63267 | S53 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P63267 | S61 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P63267 | T250 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM |
| P63267 | T319 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS |
| P63267 | T325 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS |
| P63267 | Y54 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P67809 | S136 | Sugiyama | YBX1 NSEP1 YB1 | GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR |
| P67809 | S209 | Sugiyama | YBX1 NSEP1 YB1 | RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ |
| P68032 | S325 | Sugiyama | ACTC1 ACTC | tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG |
| P68032 | S54 | Sugiyama | ACTC1 ACTC | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68032 | S62 | Sugiyama | ACTC1 ACTC | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68032 | T251 | Sugiyama | ACTC1 ACTC | tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM |
| P68032 | T320 | Sugiyama | ACTC1 ACTC | VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS |
| P68032 | T326 | Sugiyama | ACTC1 ACTC | TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS |
| P68032 | Y55 | Sugiyama | ACTC1 ACTC | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68104 | T432 | Sugiyama | EEF1A1 EEF1A EF1A LENG7 | VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT |
| P68133 | S325 | Sugiyama | ACTA1 ACTA | TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG |
| P68133 | S54 | Sugiyama | ACTA1 ACTA | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68133 | S62 | Sugiyama | ACTA1 ACTA | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68133 | T251 | Sugiyama | ACTA1 ACTA | tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM |
| P68133 | T320 | Sugiyama | ACTA1 ACTA | VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS |
| P68133 | T326 | Sugiyama | ACTA1 ACTA | TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS |
| P68133 | Y55 | Sugiyama | ACTA1 ACTA | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68363 | S48 | Sugiyama | TUBA1B | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P68363 | T334 | Sugiyama | TUBA1B | ACCLLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVG |
| P78371 | S60 | Sugiyama | CCT2 99D8.1 CCTB | KSTLGPKGMDKILLsSGRDAsLMVtNDGAtILKNIGVDNPA |
| P78417 | S23 | Sugiyama | GSTO1 GSTTLP28 | GESARsLGKGsAPPGPVPEGsIRIySMRFCPFAERTRLVLK |
| P83731 | S38 | Sugiyama | RPL24 | GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK |
| P83731 | S7 | Sugiyama | RPL24 | ______________MKVELCsFsGyKIYPGHGRRYARTDGK |
| P83731 | S86 | Sugiyama | RPL24 | EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE |
| P83731 | T83 | Sugiyama | RPL24 | QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA |
| P84098 | S122 | Sugiyama | RPL19 | LRRLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHI |
| P84098 | S37 | Sugiyama | RPL19 | CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV |
| P84098 | T29 | Sugiyama | RPL19 | RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL |
| P98082 | S723 | Sugiyama | DAB2 DOC2 | DANQLLNKINEPPKPAPRQVsLPVTKstDNAFENPFFKDsF |
| P99999 | S48 | Sugiyama | CYCS CYC | KTGPNLHGLFGRKtGQAPGysytAANKNKGIIWGEDTLMEY |
| Q00341 | S904 | Sugiyama | HDLBP HBP VGL | FHRSVMGPKGSRIQQITRDFsVQIKFPDREENAVHSTEPVV |
| Q01082 | S1388 | Sugiyama | SPTBN1 SPTB2 | TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy |
| Q01105 | S166 | Sugiyama | SET | yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT |
| Q01546 | S196 | Sugiyama | KRT76 KRT2B KRT2P | IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE |
| Q02543 | S123 | Sugiyama | RPL18A | AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK |
| Q04917 | S46 | Sugiyama | YWHAH YWHA1 | AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI |
| Q05639 | T432 | Sugiyama | EEF1A2 EEF1AL STN | VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT |
| Q06210 | S261 | Sugiyama | GFPT1 GFAT GFPT | GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA |
| Q06830 | T143 | Sugiyama | PRDX1 PAGA PAGB TDPX2 | EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF |
| Q07020 | T85 | Sugiyama | RPL18 | RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV |
| Q07866 | S445 | Sugiyama | KLC1 KLC KNS2 | PIWMHAEEREECKGKQKDGTsFGEyGGWyKACKVDsPtVTT |
| Q09028 | S147 | Sugiyama | RBBP4 RBAP48 | VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC |
| Q13283 | S362 | Sugiyama | G3BP1 G3BP | LFIGNLPHEVDKSELKDFFQsyGNVVELRINsGGKLPNFGF |
| Q13283 | S67 | Sugiyama | G3BP1 G3BP | sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN |
| Q13509 | S75 | Sugiyama | TUBB3 TUBB4 | SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS |
| Q13596 | S368 | Sugiyama | SNX1 | AKSLAMLGSSEDNTALSRALsQLAEVEEKIEQLHQEQANND |
| Q13885 | S75 | Sugiyama | TUBB2A TUBB2 | AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs |
| Q14152 | S492 | Sugiyama | EIF3A EIF3S10 KIAA0139 | VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ |
| Q14152 | S584 | Sugiyama | EIF3A EIF3S10 KIAA0139 | EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV |
| Q14152 | S988 | Sugiyama | EIF3A EIF3S10 KIAA0139 | PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN |
| Q14204 | S4162 | Sugiyama | DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 | GRIFVFEPPPGVKANMLRTFssIPVSRICKSPNERARLYFL |
| Q14568 | S165 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK |
| Q14568 | S169 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | TVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILH |
| Q14568 | S53 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG |
| Q14568 | T109 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | LTIVDTGIGMTKADLINNLGtIAKSGtKAFMEALQAGADIS |
| Q14677 | S166 | Sugiyama | CLINT1 ENTH EPN4 EPNR KIAA0171 | REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE |
| Q14677 | T215 | Sugiyama | CLINT1 ENTH EPN4 EPNR KIAA0171 | FPFSDKLGELsDKIGstIDDtIsKFRRKDREDsPERCsDsD |
| Q14CN4 | S138 | Sugiyama | KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 | IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN |
| Q15084 | S169 | Sugiyama | PDIA6 ERP5 P5 TXNDC7 | GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW |
| Q15185 | S72 | Sugiyama | PTGES3 P23 TEBP | EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE |
| Q15365 | S27 | Sugiyama | PCBP1 | ESGLNVTLTIRLLMHGKEVGsIIGKKGESVKRIREEsGARI |
| Q15366 | S27 | Sugiyama | PCBP2 | EGGLNVTLTIRLLMHGKEVGsIIGKKGESVKKMREESGARI |
| Q16513 | S583 | Sugiyama | PKN2 PRK2 PRKCL2 | VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs |
| Q16576 | S146 | Sugiyama | RBBP7 RBAP46 | VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC |
| Q2VIR3 | S282 | Sugiyama | EIF2S3B | FDVNKPGCEVDDLKGGVAGGsILKGVLKVGQETEVRPGIVS |
| Q32P51 | S95 | Sugiyama | HNRNPA1L2 HNRNPA1L | TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED |
| Q3SY84 | S143 | Sugiyama | KRT71 K6IRS1 KB34 KRT6IRS1 | IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE |
| Q3ZCM7 | S75 | Sugiyama | TUBB8 | SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC |
| Q562R1 | T250 | Sugiyama | ACTBL2 | RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI |
| Q58FF8 | T104 | Sugiyama | HSP90AB2P HSP90BB | LTLVDTGIGMTKADLINNLGtIAKFQDQTEYLEEMQVKEVV |
| Q5QNW6 | S37 | Sugiyama | H2BC18 HIST2H2BF | KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q5QNW6 | S39 | Sugiyama | H2BC18 HIST2H2BF | VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q5VTE0 | T432 | Sugiyama | EEF1A1P5 EEF1AL3 | VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT |
| Q5XKE5 | S155 | Sugiyama | KRT79 K6L KB38 KRT6L | IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA |
| Q63ZY3 | S356 | Sugiyama | KANK2 ANKRD25 KIAA1518 MXRA3 SIP | PREVEVVASTAAGAPAQRAQsLEPYGtGLRALAMPGRPEsP |
| Q6EEV6 | S28 | Sugiyama | SUMO4 SMT3H4 | EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC |
| Q6PEY2 | S48 | Sugiyama | TUBA3E | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q6PEY2 | T334 | Sugiyama | TUBA3E | ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG |
| Q6S8J3 | S1068 | Sugiyama | POTEE A26C1A POTE2 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q6S8J3 | T949 | Sugiyama | POTEE A26C1A POTE2 | tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM |
| Q6ZMR3 | S161 | Sugiyama | LDHAL6A LDHL2 | DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH |
| Q6ZMR3 | S167 | Sugiyama | LDHAL6A LDHL2 | AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG |
| Q71U36 | S48 | Sugiyama | TUBA1A TUBA3 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q71U36 | T334 | Sugiyama | TUBA1A TUBA3 | ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG |
| Q71UM5 | S78 | Sugiyama | RPS27L | GCSTVLCQPTGGKARLtEGCsFRRKQH______________ |
| Q7RTS7 | S153 | Sugiyama | KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 | IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE |
| Q7Z417 | S652 | Sugiyama | NUFIP2 KIAA1321 PIG1 | NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI |
| Q7Z794 | S177 | Sugiyama | KRT77 KRT1B | IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE |
| Q86UE4 | S339 | Sugiyama | MTDH AEG1 LYRIC | PSAWsQDtGDANtNGKDWGRsWsDRsIFsGIGstAEPVsQs |
| Q86V81 | T148 | Sugiyama | ALYREF ALY BEF THOC4 | EFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQYNG |
| Q86VQ1 | S223 | Sugiyama | GLCCI1 | QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR |
| Q86Y46 | S145 | Sugiyama | KRT73 K6IRS3 KB36 KRT6IRS3 | IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE |
| Q8N684 | S166 | Sugiyama | CPSF7 | PGKVLNGEKVDVRPAtRQNLsQFEAQARKRECVRVPRGGIP |
| Q8N6H7 | S368 | Sugiyama | ARFGAP2 ZNF289 Nbla10535 | VGTFASGPPKYKDNPFsLGEsFGsRWDTDAAWGMDRVEEKE |
| Q8N8S7 | S125 | Sugiyama | ENAH MENA | MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR |
| Q8NBJ7 | S256 | Sugiyama | SUMF2 PSEC0171 UNQ1968/PRO4500 | EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG |
| Q8NFI4 | S181 | Sugiyama | ST13P5 FAM10A5 | LQKPNAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA |
| Q8NHG7 | S46 | Sugiyama | SVIP | AEAAERRQKEAASRGILDVQsVQEKRKKKEKIEKQIATsGP |
| Q8TAM6 | S280 | Sugiyama | ERMN KIAA1189 | TISYRKIRKGNTKQRIDEFEsMMHL________________ |
| Q8TEW0 | S837 | Sugiyama | PARD3 PAR3 PAR3A | AFQREGFGRQsMsEKRtKQFsDAsQLDFVKTRKsKsMDLGI |
| Q8WWI1 | S706 | Sugiyama | LMO7 FBX20 FBXO20 KIAA0858 | RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK |
| Q93079 | S37 | Sugiyama | H2BC9 H2BFJ HIST1H2BH | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q93079 | S39 | Sugiyama | H2BC9 H2BFJ HIST1H2BH | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q96HE7 | S143 | Sugiyama | ERO1A ERO1L UNQ434/PRO865 | EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD |
| Q96IR7 | S360 | Sugiyama | HPDL GLOXD1 | LIQRQGATGFGQGNIRALWQsVQEQsARSQEA_________ |
| Q99584 | S32 | Sugiyama | S100A13 | SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD |
| Q99613 | S639 | Sugiyama | EIF3C EIF3S8 | CAFRQGLTKDAHNALLDIQssGRAKELLGQGLLLRSLQERN |
| Q99613 | S754 | Sugiyama | EIF3C EIF3S8 | REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK |
| Q99613 | S865 | Sugiyama | EIF3C EIF3S8 | HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF |
| Q99613 | T880 | Sugiyama | EIF3C EIF3S8 | AEKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMR |
| Q99614 | S155 | Sugiyama | TTC1 TPR1 | AESSYSRALEMCPSCFQKERsILFSNRAAARMKQDKKEMAI |
| Q99615 | S88 | Sugiyama | DNAJC7 TPR2 TTC2 | RAATLMMLGRFREALGDAQQsVRLDDsFVRGHLREGKCHLS |
| Q99832 | S59 | Sugiyama | CCT7 CCTH NIP7-1 | TLGPRGMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTL |
| Q99848 | S270 | Sugiyama | EBNA1BP2 EBP2 | FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN |
| Q99877 | S37 | Sugiyama | H2BC15 H2BFD HIST1H2BN | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99877 | S39 | Sugiyama | H2BC15 H2BFD HIST1H2BN | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q99879 | S37 | Sugiyama | H2BC14 H2BFE HIST1H2BM | KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99879 | S39 | Sugiyama | H2BC14 H2BFE HIST1H2BM | INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q99880 | S37 | Sugiyama | H2BC13 H2BFC HIST1H2BL | KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss |
| Q99880 | S39 | Sugiyama | H2BC13 H2BFC HIST1H2BL | VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA |
| Q9BQE3 | S48 | Sugiyama | TUBA1C TUBA6 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q9BQE3 | T334 | Sugiyama | TUBA1C TUBA6 | ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG |
| Q9BVA1 | S75 | Sugiyama | TUBB2B | tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs |
| Q9BX40 | S349 | Sugiyama | LSM14B C20orf40 FAM61B RAP55B | SSRRTTWAEERKLNtEtFGVsGRFLRGRSSRGGFRGGRGNG |
| Q9BYX7 | S368 | Sugiyama | POTEKP ACTBL3 FKSG30 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q9BYX7 | T249 | Sugiyama | POTEKP ACTBL3 FKSG30 | MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM |
| Q9GZZ9 | S24 | Sugiyama | UBA5 UBE1DC1 | SVERLQQRVQELERELAQERsLQVPRSGDGGGGRVRIEKMs |
| Q9H0C2 | S286 | Sugiyama | SLC25A31 AAC4 ANT4 SFEC | DCFVKIYQHEGISSFFRGAFsNVLRGTGGALVLVLYDKIKE |
| Q9H788 | S315 | Sugiyama | SH2D4A PPP1R38 SH2A | LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA |
| Q9NR45 | S253 | Sugiyama | NANS SAS | KVLERHITLDKTWKGsDHsAsLEPGELAELVRSVRLVERAL |
| Q9NRA8 | S353 | Sugiyama | EIF4ENIF1 | SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL |
| Q9NSB2 | S178 | Sugiyama | KRT84 KRTHB4 | AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS |
| Q9NZL9 | S9 | Sugiyama | MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 | ____________MVGREKELsIHFVPGsCRLVEEEVNIPNR |
| Q9P2B4 | S240 | Sugiyama | CTTNBP2NL KIAA1433 | ELAAERKRGLQTEAQVEKQLsEFDIEREQLRAKLNREENRT |
| Q9P2T1 | S37 | Sugiyama | GMPR2 | LRPKRSTLKsRsEVDLTRSFsFRNSKQTYSGVPIIAANMDT |
| Q9UBR2 | S78 | Sugiyama | CTSZ | SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST |
| Q9UI15 | S185 | Sugiyama | TAGLN3 NP25 | EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______ |
| Q9ULD2 | S1203 | Sugiyama | MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 | QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL |
| Q9ULD2 | T1204 | Sugiyama | MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 | ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs |
| Q9UNX3 | S31 | Sugiyama | RPL26L1 RPL26P1 | RsKNRKRHFNAPSHVRRKIMssPLSKELRQKYNVRSMPIRK |
| Q9UNX3 | T8 | Sugiyama | RPL26L1 RPL26P1 | _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK |
| Q9UNZ2 | S192 | Sugiyama | NSFL1C UBXN2C | KRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQFLEs |
| Q9UPQ0 | S201 | Sugiyama | LIMCH1 KIAA1102 | DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV |
| Q9UQ35 | S2692 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS |
| Q9UQ35 | S992 | Sugiyama | SRRM2 KIAA0324 SRL300 SRM300 HSPC075 | sssPDtKVKPEtPPRQsHsGsIsPyPKVKAQtPPGPsLsGs |
| Q9Y230 | S43 | Sugiyama | RUVBL2 INO80J TIP48 TIP49B CGI-46 | GAHSHIRGLGLDDALEPRQAsQGMVGQLAARRAAGVVLEMI |
| Q9Y2B0 | S116 | Sugiyama | CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 | IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA |
| Q9Y2B0 | S55 | Sugiyama | CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 | VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE |
| Q9Y2B0 | S65 | Sugiyama | CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 | VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI |
| Q9Y3B8 | S203 | Sugiyama | REXO2 SFN SMFN CGI-114 | EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK |
| Q9Y3U8 | S91 | Sugiyama | RPL36 | KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______ |
| Q9Y5L4 | S57 | Sugiyama | TIMM13 TIM13B TIMM13A TIMM13B | ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW |
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Cell Cycle | R-HSA-1640170 | 1.129319e-12 | 11.947 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 1.188827e-12 | 11.925 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 5.985586e-10 | 9.223 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 2.485211e-09 | 8.605 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 1.908185e-08 | 7.719 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 4.169166e-08 | 7.380 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 4.169166e-08 | 7.380 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 4.702009e-08 | 7.328 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 8.724615e-08 | 7.059 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 2.564222e-07 | 6.591 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 3.487593e-07 | 6.457 | 0 | 0 |
| M Phase | R-HSA-68886 | 4.197934e-07 | 6.377 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 5.454664e-07 | 6.263 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 6.346660e-07 | 6.197 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 8.548626e-07 | 6.068 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 1.711523e-06 | 5.767 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 1.868261e-06 | 5.729 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 2.655495e-06 | 5.576 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 3.388469e-06 | 5.470 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 3.862362e-06 | 5.413 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 4.622889e-06 | 5.335 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 5.254895e-06 | 5.279 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 8.531969e-06 | 5.069 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 9.233752e-06 | 5.035 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 9.323707e-06 | 5.030 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 1.041425e-05 | 4.982 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 1.250098e-05 | 4.903 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 1.990390e-05 | 4.701 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 2.337079e-05 | 4.631 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 3.244780e-05 | 4.489 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 3.290209e-05 | 4.483 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 4.083314e-05 | 4.389 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 3.954113e-05 | 4.403 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 4.354956e-05 | 4.361 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 5.694014e-05 | 4.245 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 5.837273e-05 | 4.234 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 6.057751e-05 | 4.218 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 7.004411e-05 | 4.155 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 8.045373e-05 | 4.094 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 8.799944e-05 | 4.056 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 1.011138e-04 | 3.995 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 1.509880e-04 | 3.821 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 1.509880e-04 | 3.821 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 1.708928e-04 | 3.767 | 0 | 0 |
| NFE2L2 regulating MDR associated enzymes | R-HSA-9818032 | 1.880328e-04 | 3.726 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 1.990619e-04 | 3.701 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 2.323994e-04 | 3.634 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 2.389642e-04 | 3.622 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 2.771635e-04 | 3.557 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 2.613083e-04 | 3.583 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 2.934537e-04 | 3.532 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 2.668469e-04 | 3.574 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 2.813314e-04 | 3.551 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 2.642144e-04 | 3.578 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 2.771635e-04 | 3.557 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 2.937384e-04 | 3.532 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 2.937161e-04 | 3.532 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 3.145333e-04 | 3.502 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 3.673432e-04 | 3.435 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 3.922574e-04 | 3.406 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 3.979055e-04 | 3.400 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 4.379615e-04 | 3.359 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 4.543914e-04 | 3.343 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 4.568638e-04 | 3.340 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 4.635980e-04 | 3.334 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 5.045492e-04 | 3.297 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 5.510416e-04 | 3.259 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 5.725270e-04 | 3.242 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 5.933228e-04 | 3.227 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 6.637429e-04 | 3.178 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 6.853399e-04 | 3.164 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 7.378906e-04 | 3.132 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 7.951352e-04 | 3.100 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 8.883809e-04 | 3.051 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 8.621979e-04 | 3.064 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 9.583919e-04 | 3.018 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 1.012909e-03 | 2.994 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 1.038880e-03 | 2.983 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 1.106233e-03 | 2.956 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 1.145438e-03 | 2.941 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 1.192126e-03 | 2.924 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 1.203502e-03 | 2.920 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 1.264090e-03 | 2.898 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 1.341691e-03 | 2.872 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 1.428657e-03 | 2.845 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 1.438483e-03 | 2.842 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 1.452577e-03 | 2.838 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 1.452577e-03 | 2.838 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 1.452577e-03 | 2.838 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 1.452577e-03 | 2.838 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 1.591948e-03 | 2.798 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 1.719821e-03 | 2.765 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 1.764303e-03 | 2.753 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 1.850168e-03 | 2.733 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 2.167244e-03 | 2.664 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 2.167244e-03 | 2.664 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 2.277681e-03 | 2.643 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 2.294720e-03 | 2.639 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 2.393509e-03 | 2.621 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 2.400775e-03 | 2.620 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 2.478350e-03 | 2.606 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 2.690876e-03 | 2.570 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 2.726862e-03 | 2.564 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 2.775428e-03 | 2.557 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 2.948212e-03 | 2.530 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 2.999725e-03 | 2.523 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 3.074441e-03 | 2.512 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 3.168995e-03 | 2.499 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 3.197566e-03 | 2.495 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 3.145110e-03 | 2.502 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 3.287800e-03 | 2.483 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 3.386601e-03 | 2.470 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 3.386601e-03 | 2.470 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 3.447508e-03 | 2.462 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 3.494076e-03 | 2.457 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 3.685740e-03 | 2.433 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 3.569212e-03 | 2.447 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 3.770706e-03 | 2.424 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 3.569212e-03 | 2.447 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 3.897181e-03 | 2.409 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 3.991563e-03 | 2.399 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 4.129750e-03 | 2.384 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 4.261552e-03 | 2.370 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 4.129750e-03 | 2.384 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 4.292778e-03 | 2.367 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 4.200401e-03 | 2.377 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 3.991563e-03 | 2.399 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 4.143197e-03 | 2.383 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 4.042651e-03 | 2.393 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 4.298035e-03 | 2.367 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 4.350478e-03 | 2.361 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 4.350478e-03 | 2.361 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 4.371527e-03 | 2.359 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 4.372555e-03 | 2.359 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 4.577662e-03 | 2.339 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 4.664747e-03 | 2.331 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 4.930401e-03 | 2.307 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 5.055615e-03 | 2.296 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 4.744908e-03 | 2.324 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 5.055615e-03 | 2.296 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 5.017023e-03 | 2.300 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 5.055615e-03 | 2.296 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 5.381018e-03 | 2.269 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 5.444742e-03 | 2.264 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.753404e-03 | 2.240 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 5.888783e-03 | 2.230 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 5.888783e-03 | 2.230 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 5.954270e-03 | 2.225 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 6.017375e-03 | 2.221 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 6.725576e-03 | 2.172 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 6.170754e-03 | 2.210 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 6.742735e-03 | 2.171 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 6.952623e-03 | 2.158 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 7.023353e-03 | 2.153 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 7.349754e-03 | 2.134 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 7.357365e-03 | 2.133 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 7.357365e-03 | 2.133 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 7.357365e-03 | 2.133 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 7.357365e-03 | 2.133 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 7.648951e-03 | 2.116 | 0 | 0 |
| Transcriptional activation of cell cycle inhibitor p21 | R-HSA-69895 | 7.708196e-03 | 2.113 | 0 | 0 |
| Transcriptional activation of p53 responsive genes | R-HSA-69560 | 7.708196e-03 | 2.113 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of cell cycle factors | R-HSA-8866911 | 7.708196e-03 | 2.113 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 7.708196e-03 | 2.113 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 8.448612e-03 | 2.073 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 8.448612e-03 | 2.073 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 9.074287e-03 | 2.042 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 9.315485e-03 | 2.031 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 9.368459e-03 | 2.028 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 9.368459e-03 | 2.028 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 9.368459e-03 | 2.028 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 9.676330e-03 | 2.014 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 9.730556e-03 | 2.012 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 9.732301e-03 | 2.012 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 9.923644e-03 | 2.003 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 9.923644e-03 | 2.003 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 1.028251e-02 | 1.988 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 1.062045e-02 | 1.974 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 1.084301e-02 | 1.965 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 1.094519e-02 | 1.961 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 1.096699e-02 | 1.960 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 1.283744e-02 | 1.892 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 1.207251e-02 | 1.918 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 1.295563e-02 | 1.888 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 1.226597e-02 | 1.911 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 1.297308e-02 | 1.887 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 1.312929e-02 | 1.882 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 1.330198e-02 | 1.876 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 1.333110e-02 | 1.875 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 1.333937e-02 | 1.875 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 1.338290e-02 | 1.873 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 1.338487e-02 | 1.873 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 1.400563e-02 | 1.854 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 1.421329e-02 | 1.847 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 1.430680e-02 | 1.844 | 0 | 0 |
| Depurination | R-HSA-73927 | 1.436381e-02 | 1.843 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 1.442253e-02 | 1.841 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 1.442253e-02 | 1.841 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 1.502412e-02 | 1.823 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 1.672365e-02 | 1.777 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 1.633037e-02 | 1.787 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 1.614559e-02 | 1.792 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 1.649987e-02 | 1.783 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 1.533900e-02 | 1.814 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 1.517835e-02 | 1.819 | 0 | 0 |
| Kinesins | R-HSA-983189 | 1.569960e-02 | 1.804 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 1.562418e-02 | 1.806 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 1.681256e-02 | 1.774 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 1.569960e-02 | 1.804 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 1.776272e-02 | 1.750 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 1.776272e-02 | 1.750 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 1.776272e-02 | 1.750 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 1.776272e-02 | 1.750 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 1.776272e-02 | 1.750 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 1.776272e-02 | 1.750 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 1.814572e-02 | 1.741 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 1.821247e-02 | 1.740 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 1.880490e-02 | 1.726 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 1.941943e-02 | 1.712 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 1.945372e-02 | 1.711 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 1.954023e-02 | 1.709 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 1.975308e-02 | 1.704 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 1.975308e-02 | 1.704 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 1.975308e-02 | 1.704 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 2.001406e-02 | 1.699 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 2.001406e-02 | 1.699 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 2.001406e-02 | 1.699 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 2.001406e-02 | 1.699 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 2.080304e-02 | 1.682 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 2.303301e-02 | 1.638 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 2.413033e-02 | 1.617 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 2.413033e-02 | 1.617 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 2.264027e-02 | 1.645 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 2.332715e-02 | 1.632 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 2.413033e-02 | 1.617 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 2.413033e-02 | 1.617 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 2.339225e-02 | 1.631 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 2.414361e-02 | 1.617 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 2.414361e-02 | 1.617 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 2.439526e-02 | 1.613 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 2.462835e-02 | 1.609 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 2.462835e-02 | 1.609 | 0 | 0 |
| Formation of editosomes by ADAR proteins | R-HSA-77042 | 2.732032e-02 | 1.564 | 0 | 0 |
| Axonal growth stimulation | R-HSA-209563 | 2.675490e-02 | 1.573 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 2.907934e-02 | 1.536 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 2.907934e-02 | 1.536 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 3.014643e-02 | 1.521 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 2.764856e-02 | 1.558 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 3.024157e-02 | 1.519 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 3.035630e-02 | 1.518 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 3.035630e-02 | 1.518 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 2.970722e-02 | 1.527 | 0 | 0 |
| Receptor Mediated Mitophagy | R-HSA-8934903 | 2.663803e-02 | 1.574 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 2.663803e-02 | 1.574 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 2.739808e-02 | 1.562 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 2.739808e-02 | 1.562 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 2.782879e-02 | 1.556 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 2.863711e-02 | 1.543 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 2.855438e-02 | 1.544 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 2.915060e-02 | 1.535 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 2.915060e-02 | 1.535 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 3.052601e-02 | 1.515 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 3.149994e-02 | 1.502 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 3.169133e-02 | 1.499 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 3.248086e-02 | 1.488 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 3.370063e-02 | 1.472 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 3.420116e-02 | 1.466 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 3.486317e-02 | 1.458 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 3.488681e-02 | 1.457 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 3.488681e-02 | 1.457 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 3.488681e-02 | 1.457 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 3.488681e-02 | 1.457 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 3.488986e-02 | 1.457 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 3.641684e-02 | 1.439 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 3.641684e-02 | 1.439 | 0 | 0 |
| HCN channels | R-HSA-1296061 | 4.218125e-02 | 1.375 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 4.218125e-02 | 1.375 | 0 | 0 |
| ATP sensitive Potassium channels | R-HSA-1296025 | 4.218125e-02 | 1.375 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 4.022322e-02 | 1.396 | 0 | 0 |
| Ca2+ activated K+ channels | R-HSA-1296052 | 4.022322e-02 | 1.396 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 3.650562e-02 | 1.438 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 3.650562e-02 | 1.438 | 0 | 0 |
| Adenylate cyclase inhibitory pathway | R-HSA-170670 | 3.650562e-02 | 1.438 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 3.650562e-02 | 1.438 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 4.316269e-02 | 1.365 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 4.064820e-02 | 1.391 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 4.370930e-02 | 1.359 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 4.349620e-02 | 1.362 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 3.796987e-02 | 1.421 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 3.766141e-02 | 1.424 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 3.777695e-02 | 1.423 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 4.193627e-02 | 1.377 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 4.208862e-02 | 1.376 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 3.997325e-02 | 1.398 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 3.997325e-02 | 1.398 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 4.022322e-02 | 1.396 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 3.650562e-02 | 1.438 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 4.134205e-02 | 1.384 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 3.695757e-02 | 1.432 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 3.805882e-02 | 1.420 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 3.896815e-02 | 1.409 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 3.650562e-02 | 1.438 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 4.366173e-02 | 1.360 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 4.022322e-02 | 1.396 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 4.064820e-02 | 1.391 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 4.370930e-02 | 1.359 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 4.372341e-02 | 1.359 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 4.455493e-02 | 1.351 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 4.455493e-02 | 1.351 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 4.455493e-02 | 1.351 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 4.480611e-02 | 1.349 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 4.480611e-02 | 1.349 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 4.480611e-02 | 1.349 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 4.606704e-02 | 1.337 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 4.670928e-02 | 1.331 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 4.714166e-02 | 1.327 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 4.717169e-02 | 1.326 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 4.717169e-02 | 1.326 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 4.717169e-02 | 1.326 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 4.717169e-02 | 1.326 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 4.751312e-02 | 1.323 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 4.751312e-02 | 1.323 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 4.819868e-02 | 1.317 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 5.013173e-02 | 1.300 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 5.115903e-02 | 1.291 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 5.181422e-02 | 1.286 | 0 | 0 |
| TGFBR3 regulates FGF2 signaling | R-HSA-9839397 | 5.660941e-02 | 1.247 | 0 | 0 |
| Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | R-HSA-73930 | 5.660941e-02 | 1.247 | 0 | 0 |
| Interactions of Tat with host cellular proteins | R-HSA-176034 | 5.660941e-02 | 1.247 | 0 | 0 |
| Transport of glycerol from adipocytes to the liver by Aquaporins | R-HSA-432030 | 5.660941e-02 | 1.247 | 0 | 0 |
| Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome | R-HSA-5678420 | 5.660941e-02 | 1.247 | 0 | 0 |
| MyD88 deficiency (TLR5) | R-HSA-5602680 | 5.660941e-02 | 1.247 | 0 | 0 |
| TWIK-releated acid-sensitive K+ channel (TASK) | R-HSA-1299316 | 5.660941e-02 | 1.247 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 5.347334e-02 | 1.272 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 5.347334e-02 | 1.272 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 5.567290e-02 | 1.254 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 5.567290e-02 | 1.254 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 6.468506e-02 | 1.189 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 6.339968e-02 | 1.198 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 5.737100e-02 | 1.241 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 6.512942e-02 | 1.186 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 6.512942e-02 | 1.186 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 5.850174e-02 | 1.233 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 5.850174e-02 | 1.233 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 5.882291e-02 | 1.230 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 5.266102e-02 | 1.279 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 5.789762e-02 | 1.237 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 6.382962e-02 | 1.195 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 5.844033e-02 | 1.233 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 5.641175e-02 | 1.249 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 6.253254e-02 | 1.204 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 6.489897e-02 | 1.188 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 5.509183e-02 | 1.259 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 5.419368e-02 | 1.266 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 6.115420e-02 | 1.214 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 6.468506e-02 | 1.189 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 5.737100e-02 | 1.241 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 6.512942e-02 | 1.186 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 5.347334e-02 | 1.272 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 5.567290e-02 | 1.254 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 6.038531e-02 | 1.219 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 6.512942e-02 | 1.186 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 5.567290e-02 | 1.254 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 5.347334e-02 | 1.272 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 5.882291e-02 | 1.230 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 6.249649e-02 | 1.204 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 5.347334e-02 | 1.272 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 5.347334e-02 | 1.272 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 5.320749e-02 | 1.274 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 6.468506e-02 | 1.189 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 5.789762e-02 | 1.237 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 6.530591e-02 | 1.185 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 6.574518e-02 | 1.182 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 6.574518e-02 | 1.182 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 6.653237e-02 | 1.177 | 0 | 0 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | R-HSA-9661069 | 6.824689e-02 | 1.166 | 0 | 0 |
| RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | R-HSA-8877330 | 6.824689e-02 | 1.166 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 6.824689e-02 | 1.166 | 0 | 0 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | R-HSA-9659787 | 6.824689e-02 | 1.166 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 6.841540e-02 | 1.165 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 6.844397e-02 | 1.165 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 6.880392e-02 | 1.162 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 6.880392e-02 | 1.162 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 6.880392e-02 | 1.162 | 0 | 0 |
| mRNA Editing | R-HSA-75072 | 6.880392e-02 | 1.162 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 6.880392e-02 | 1.162 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 6.880392e-02 | 1.162 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 7.007324e-02 | 1.154 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 7.241148e-02 | 1.140 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 7.244663e-02 | 1.140 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 7.258318e-02 | 1.139 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 7.351930e-02 | 1.134 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 7.351930e-02 | 1.134 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 7.351930e-02 | 1.134 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 7.353824e-02 | 1.133 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 7.353824e-02 | 1.133 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 7.353824e-02 | 1.133 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 7.589423e-02 | 1.120 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 7.590295e-02 | 1.120 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 7.605068e-02 | 1.119 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 7.628383e-02 | 1.118 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 7.686890e-02 | 1.114 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 7.686890e-02 | 1.114 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 8.058819e-02 | 1.094 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 8.143796e-02 | 1.089 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 8.188619e-02 | 1.087 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 8.223709e-02 | 1.085 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 8.223709e-02 | 1.085 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 8.223709e-02 | 1.085 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 8.225998e-02 | 1.085 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 8.225998e-02 | 1.085 | 0 | 0 |
| cGMP effects | R-HSA-418457 | 8.225998e-02 | 1.085 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 8.225998e-02 | 1.085 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 8.225998e-02 | 1.085 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 8.254559e-02 | 1.083 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 8.254559e-02 | 1.083 | 0 | 0 |
| GLI proteins bind promoters of Hh responsive genes to promote transcription | R-HSA-5635851 | 8.340039e-02 | 1.079 | 0 | 0 |
| Signaling by MAPK mutants | R-HSA-9652817 | 8.340039e-02 | 1.079 | 0 | 0 |
| PKA-mediated phosphorylation of key metabolic factors | R-HSA-163358 | 8.340039e-02 | 1.079 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 8.398587e-02 | 1.076 | 0 | 0 |
| S Phase | R-HSA-69242 | 8.504780e-02 | 1.070 | 0 | 0 |
| mRNA Editing: A to I Conversion | R-HSA-75064 | 9.276682e-02 | 1.033 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 9.276682e-02 | 1.033 | 0 | 0 |
| Diseases of Cellular Senescence | R-HSA-9630747 | 9.276682e-02 | 1.033 | 0 | 0 |
| Diseases of cellular response to stress | R-HSA-9675132 | 9.276682e-02 | 1.033 | 0 | 0 |
| C6 deamination of adenosine | R-HSA-75102 | 9.276682e-02 | 1.033 | 0 | 0 |
| Potassium transport channels | R-HSA-1296067 | 9.276682e-02 | 1.033 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 8.614294e-02 | 1.065 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 8.614294e-02 | 1.065 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 9.276998e-02 | 1.033 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 1.040388e-01 | 0.983 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 1.040388e-01 | 0.983 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 1.040388e-01 | 0.983 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 1.134327e-01 | 0.945 | 0 | 0 |
| Voltage gated Potassium channels | R-HSA-1296072 | 1.134327e-01 | 0.945 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 9.942773e-02 | 1.002 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 8.751658e-02 | 1.058 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 8.898074e-02 | 1.051 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 9.079133e-02 | 1.042 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 9.942773e-02 | 1.002 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 1.002530e-01 | 0.999 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 1.043860e-01 | 0.981 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 1.002530e-01 | 0.999 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 1.001852e-01 | 0.999 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 8.882592e-02 | 1.051 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 9.220925e-02 | 1.035 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 8.829532e-02 | 1.054 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 1.115803e-01 | 0.952 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 8.614294e-02 | 1.065 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 9.276998e-02 | 1.033 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 9.942773e-02 | 1.002 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 9.942773e-02 | 1.002 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 9.942773e-02 | 1.002 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 9.942773e-02 | 1.002 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 9.522378e-02 | 1.021 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 9.767404e-02 | 1.010 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 1.100211e-01 | 0.959 | 0 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 1.085667e-01 | 0.964 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 1.053798e-01 | 0.977 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 8.729463e-02 | 1.059 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 9.540468e-02 | 1.020 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 1.038251e-01 | 0.984 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 1.002530e-01 | 0.999 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 9.942773e-02 | 1.002 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 1.069869e-01 | 0.971 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 1.099037e-01 | 0.959 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 8.614294e-02 | 1.065 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 1.102674e-01 | 0.958 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 8.651306e-02 | 1.063 | 0 | 0 |
| Phase 4 - resting membrane potential | R-HSA-5576886 | 1.144319e-01 | 0.941 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 1.149004e-01 | 0.940 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 1.151513e-01 | 0.939 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 1.164802e-01 | 0.934 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 1.164990e-01 | 0.934 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 1.175721e-01 | 0.930 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 1.175721e-01 | 0.930 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 1.175721e-01 | 0.930 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 1.176519e-01 | 0.929 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 1.181002e-01 | 0.928 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 1.181002e-01 | 0.928 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 1.189733e-01 | 0.925 | 0 | 0 |
| Drug resistance of KIT mutants | R-HSA-9669937 | 1.193748e-01 | 0.923 | 0 | 0 |
| KIT mutants bind TKIs | R-HSA-9669921 | 1.193748e-01 | 0.923 | 0 | 0 |
| Imatinib-resistant KIT mutants | R-HSA-9669917 | 1.193748e-01 | 0.923 | 0 | 0 |
| Loss of function of TP53 in cancer due to loss of tetramerization ability | R-HSA-9723905 | 1.193748e-01 | 0.923 | 0 | 0 |
| Loss of Function of TP53 in Cancer | R-HSA-9723907 | 1.193748e-01 | 0.923 | 0 | 0 |
| Sorafenib-resistant KIT mutants | R-HSA-9669936 | 1.193748e-01 | 0.923 | 0 | 0 |
| Nilotinib-resistant KIT mutants | R-HSA-9669926 | 1.193748e-01 | 0.923 | 0 | 0 |
| Masitinib-resistant KIT mutants | R-HSA-9669924 | 1.193748e-01 | 0.923 | 0 | 0 |
| Evasion of Oncogene Induced Senescence Due to p14ARF Defects | R-HSA-9646303 | 1.193748e-01 | 0.923 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 1.193748e-01 | 0.923 | 0 | 0 |
| Sunitinib-resistant KIT mutants | R-HSA-9669934 | 1.193748e-01 | 0.923 | 0 | 0 |
| Dasatinib-resistant KIT mutants | R-HSA-9669914 | 1.193748e-01 | 0.923 | 0 | 0 |
| Regorafenib-resistant KIT mutants | R-HSA-9669929 | 1.193748e-01 | 0.923 | 0 | 0 |
| Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects | R-HSA-9646304 | 1.193748e-01 | 0.923 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 1.215302e-01 | 0.915 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 1.215302e-01 | 0.915 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 1.215302e-01 | 0.915 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 1.249748e-01 | 0.903 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 1.263731e-01 | 0.898 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 1.263731e-01 | 0.898 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 1.263731e-01 | 0.898 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 1.287315e-01 | 0.890 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 1.287315e-01 | 0.890 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 1.287315e-01 | 0.890 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 1.287315e-01 | 0.890 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 1.287315e-01 | 0.890 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 1.289290e-01 | 0.890 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 1.317460e-01 | 0.880 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 1.317460e-01 | 0.880 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 1.317460e-01 | 0.880 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 1.317460e-01 | 0.880 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 1.324599e-01 | 0.878 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 1.333906e-01 | 0.875 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 1.333906e-01 | 0.875 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 1.333906e-01 | 0.875 | 0 | 0 |
| Activation of BIM and translocation to mitochondria | R-HSA-111446 | 1.337370e-01 | 0.874 | 0 | 0 |
| IRAK4 deficiency (TLR5) | R-HSA-5603037 | 1.337370e-01 | 0.874 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 1.362542e-01 | 0.866 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 1.362542e-01 | 0.866 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 1.362542e-01 | 0.866 | 0 | 0 |
| Netrin mediated repulsion signals | R-HSA-418886 | 1.362542e-01 | 0.866 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose | R-HSA-9031528 | 1.362542e-01 | 0.866 | 0 | 0 |
| Cation-coupled Chloride cotransporters | R-HSA-426117 | 1.362542e-01 | 0.866 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 1.362542e-01 | 0.866 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 1.367873e-01 | 0.864 | 0 | 0 |
| Regulation of HMOX1 expression and activity | R-HSA-9707587 | 1.778568e-01 | 0.750 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 1.778568e-01 | 0.750 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 1.778568e-01 | 0.750 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 1.778568e-01 | 0.750 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 1.778568e-01 | 0.750 | 0 | 0 |
| FBXW7 Mutants and NOTCH1 in Cancer | R-HSA-2644605 | 1.778568e-01 | 0.750 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 1.778568e-01 | 0.750 | 0 | 0 |
| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | R-HSA-2644607 | 1.778568e-01 | 0.750 | 0 | 0 |
| Axonal growth inhibition (RHOA activation) | R-HSA-193634 | 1.660445e-01 | 0.780 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 1.660445e-01 | 0.780 | 0 | 0 |
| RSK activation | R-HSA-444257 | 1.660445e-01 | 0.780 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 1.660445e-01 | 0.780 | 0 | 0 |
| FGFR1b ligand binding and activation | R-HSA-190370 | 1.660445e-01 | 0.780 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 1.489581e-01 | 0.827 | 0 | 0 |
| p75NTR regulates axonogenesis | R-HSA-193697 | 1.975184e-01 | 0.704 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 1.975184e-01 | 0.704 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 1.729531e-01 | 0.762 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 1.719639e-01 | 0.765 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 1.501577e-01 | 0.823 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 1.932331e-01 | 0.714 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 1.678129e-01 | 0.775 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 1.678129e-01 | 0.775 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 2.055134e-01 | 0.687 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 1.708339e-01 | 0.767 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 1.556780e-01 | 0.808 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 1.416543e-01 | 0.849 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 1.553070e-01 | 0.809 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 1.575715e-01 | 0.803 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 1.990427e-01 | 0.701 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 1.990427e-01 | 0.701 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 1.783855e-01 | 0.749 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 2.000119e-01 | 0.699 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 1.798516e-01 | 0.745 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 1.473605e-01 | 0.832 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 2.004742e-01 | 0.698 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 1.932331e-01 | 0.714 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 1.719639e-01 | 0.765 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 2.061353e-01 | 0.686 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 1.631394e-01 | 0.787 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 1.523463e-01 | 0.817 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 1.622803e-01 | 0.790 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 2.055134e-01 | 0.687 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 1.861012e-01 | 0.730 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 1.913115e-01 | 0.718 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 1.949401e-01 | 0.710 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 1.949401e-01 | 0.710 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 1.974200e-01 | 0.705 | 0 | 0 |
| Activation of NOXA and translocation to mitochondria | R-HSA-111448 | 1.778568e-01 | 0.750 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 1.975184e-01 | 0.704 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 1.981664e-01 | 0.703 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 1.975184e-01 | 0.704 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 1.932331e-01 | 0.714 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 1.913115e-01 | 0.718 | 0 | 0 |
| Dopamine receptors | R-HSA-390651 | 1.778568e-01 | 0.750 | 0 | 0 |
| PKA activation | R-HSA-163615 | 1.719639e-01 | 0.765 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 1.462790e-01 | 0.835 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 1.660445e-01 | 0.780 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 1.619556e-01 | 0.791 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 1.729531e-01 | 0.762 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 1.981664e-01 | 0.703 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 1.538659e-01 | 0.813 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 1.397364e-01 | 0.855 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 1.461516e-01 | 0.835 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 1.813956e-01 | 0.741 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 1.729531e-01 | 0.762 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 1.622803e-01 | 0.790 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 1.913115e-01 | 0.718 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 1.556780e-01 | 0.808 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 1.705983e-01 | 0.768 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 1.719639e-01 | 0.765 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 1.476916e-01 | 0.831 | 0 | 0 |
| Nitric oxide stimulates guanylate cyclase | R-HSA-392154 | 1.622803e-01 | 0.790 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 2.019256e-01 | 0.695 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 2.049456e-01 | 0.688 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 1.678129e-01 | 0.775 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 1.423572e-01 | 0.847 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 1.703616e-01 | 0.769 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 1.813956e-01 | 0.741 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 1.990427e-01 | 0.701 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 1.990427e-01 | 0.701 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 1.975184e-01 | 0.704 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 1.719639e-01 | 0.765 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 1.501577e-01 | 0.823 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 1.498478e-01 | 0.824 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 1.485083e-01 | 0.828 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 1.793048e-01 | 0.746 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 1.949463e-01 | 0.710 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 1.892761e-01 | 0.723 | 0 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 2.055134e-01 | 0.687 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 1.421167e-01 | 0.847 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 1.556780e-01 | 0.808 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 1.797526e-01 | 0.745 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 1.975184e-01 | 0.704 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 2.061353e-01 | 0.686 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 1.932331e-01 | 0.714 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 1.378263e-01 | 0.861 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 1.729531e-01 | 0.762 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 1.719639e-01 | 0.765 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 1.797526e-01 | 0.745 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 1.894192e-01 | 0.723 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 1.660445e-01 | 0.780 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 1.431191e-01 | 0.844 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 2.089237e-01 | 0.680 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 2.115664e-01 | 0.675 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 2.116255e-01 | 0.674 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 2.120198e-01 | 0.674 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 2.132846e-01 | 0.671 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 2.132846e-01 | 0.671 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 2.143967e-01 | 0.669 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 2.153635e-01 | 0.667 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 2.153635e-01 | 0.667 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 2.153635e-01 | 0.667 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 2.153635e-01 | 0.667 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 2.153635e-01 | 0.667 | 0 | 0 |
| Immune System | R-HSA-168256 | 2.153667e-01 | 0.667 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 2.245053e-01 | 0.649 | 0 | 0 |
| Regulation of PAK-2p34 activity by PS-GAP/RHG10 | R-HSA-211728 | 2.245053e-01 | 0.649 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective SLC26A4 causes Pendred syndrome (PDS) | R-HSA-5619046 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH6 | R-HSA-5632968 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | R-HSA-9645722 | 2.245053e-01 | 0.649 | 0 | 0 |
| Impaired BRCA2 translocation to the nucleus | R-HSA-9709275 | 2.245053e-01 | 0.649 | 0 | 0 |
| Impaired BRCA2 binding to SEM1 (DSS1) | R-HSA-9763198 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective ACTH causes obesity and POMCD | R-HSA-5579031 | 2.245053e-01 | 0.649 | 0 | 0 |
| TICAM1 deficiency - HSE | R-HSA-5602566 | 2.245053e-01 | 0.649 | 0 | 0 |
| Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 | R-HSA-9630791 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective DNA double strand break response due to BRCA1 loss of function | R-HSA-9663199 | 2.245053e-01 | 0.649 | 0 | 0 |
| Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 | R-HSA-9632697 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective DNA double strand break response due to BARD1 loss of function | R-HSA-9699150 | 2.245053e-01 | 0.649 | 0 | 0 |
| PI and PC transport between ER and Golgi membranes | R-HSA-1483196 | 3.170906e-01 | 0.499 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 3.170906e-01 | 0.499 | 0 | 0 |
| NFG and proNGF binds to p75NTR | R-HSA-205017 | 3.170906e-01 | 0.499 | 0 | 0 |
| Signaling by extracellular domain mutants of KIT | R-HSA-9680187 | 3.170906e-01 | 0.499 | 0 | 0 |
| Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | R-HSA-9630750 | 3.170906e-01 | 0.499 | 0 | 0 |
| Signaling by juxtamembrane domain KIT mutants | R-HSA-9669935 | 3.170906e-01 | 0.499 | 0 | 0 |
| Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | R-HSA-9632693 | 3.170906e-01 | 0.499 | 0 | 0 |
| TRAF3 deficiency - HSE | R-HSA-5602571 | 3.170906e-01 | 0.499 | 0 | 0 |
| Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 | R-HSA-9632700 | 3.170906e-01 | 0.499 | 0 | 0 |
| TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | R-HSA-6791055 | 3.170906e-01 | 0.499 | 0 | 0 |
| Defective SLC12A3 causes Gitelman syndrome (GS) | R-HSA-5619087 | 3.170906e-01 | 0.499 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 3.170906e-01 | 0.499 | 0 | 0 |
| Loss of Function of SMAD4 in Cancer | R-HSA-3304347 | 3.170906e-01 | 0.499 | 0 | 0 |
| SMAD2/3 MH2 Domain Mutants in Cancer | R-HSA-3315487 | 3.170906e-01 | 0.499 | 0 | 0 |
| Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) | R-HSA-5619039 | 3.170906e-01 | 0.499 | 0 | 0 |
| Signaling by kinase domain mutants of KIT | R-HSA-9669933 | 3.170906e-01 | 0.499 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 3.170906e-01 | 0.499 | 0 | 0 |
| Intestinal infectious diseases | R-HSA-8942233 | 3.170906e-01 | 0.499 | 0 | 0 |
| Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | R-HSA-5619081 | 3.170906e-01 | 0.499 | 0 | 0 |
| Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 | R-HSA-9630794 | 3.170906e-01 | 0.499 | 0 | 0 |
| TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | R-HSA-6791462 | 3.170906e-01 | 0.499 | 0 | 0 |
| MPS IIID - Sanfilippo syndrome D | R-HSA-2206305 | 3.170906e-01 | 0.499 | 0 | 0 |
| Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) | R-HSA-5660724 | 3.170906e-01 | 0.499 | 0 | 0 |
| SMAD4 MH2 Domain Mutants in Cancer | R-HSA-3311021 | 3.170906e-01 | 0.499 | 0 | 0 |
| Signaling by TCF7L2 mutants | R-HSA-5339700 | 3.170906e-01 | 0.499 | 0 | 0 |
| Resolution of AP sites via the single-nucleotide replacement pathway | R-HSA-110381 | 2.237913e-01 | 0.650 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 2.237913e-01 | 0.650 | 0 | 0 |
| NFE2L2 regulating inflammation associated genes | R-HSA-9818026 | 2.237913e-01 | 0.650 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 2.237913e-01 | 0.650 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 2.237913e-01 | 0.650 | 0 | 0 |
| G2 Phase | R-HSA-68911 | 2.237913e-01 | 0.650 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 2.704792e-01 | 0.568 | 0 | 0 |
| TRAIL signaling | R-HSA-75158 | 2.704792e-01 | 0.568 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 2.704792e-01 | 0.568 | 0 | 0 |
| PTK6 Regulates Cell Cycle | R-HSA-8849470 | 2.704792e-01 | 0.568 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 2.704792e-01 | 0.568 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 2.704792e-01 | 0.568 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 3.986270e-01 | 0.399 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 3.986270e-01 | 0.399 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 3.986270e-01 | 0.399 | 0 | 0 |
| Interaction between PHLDA1 and AURKA | R-HSA-8854521 | 3.986270e-01 | 0.399 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 3.986270e-01 | 0.399 | 0 | 0 |
| Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | R-HSA-5655799 | 3.986270e-01 | 0.399 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 3.986270e-01 | 0.399 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 3.986270e-01 | 0.399 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 3.986270e-01 | 0.399 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 3.986270e-01 | 0.399 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 3.986270e-01 | 0.399 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 3.986270e-01 | 0.399 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 3.986270e-01 | 0.399 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 3.986270e-01 | 0.399 | 0 | 0 |
| Mitotic Metaphase/Anaphase Transition | R-HSA-68881 | 3.986270e-01 | 0.399 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 3.986270e-01 | 0.399 | 0 | 0 |
| TWIK related potassium channel (TREK) | R-HSA-1299503 | 3.986270e-01 | 0.399 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 2.302697e-01 | 0.638 | 0 | 0 |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | 2.302697e-01 | 0.638 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 2.302697e-01 | 0.638 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 3.170864e-01 | 0.499 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in WNT signaling | R-HSA-8939256 | 3.170864e-01 | 0.499 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 3.170864e-01 | 0.499 | 0 | 0 |
| Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | R-HSA-629587 | 3.170864e-01 | 0.499 | 0 | 0 |
| ChREBP activates metabolic gene expression | R-HSA-163765 | 2.639152e-01 | 0.579 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 2.639152e-01 | 0.579 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 2.639152e-01 | 0.579 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 2.244011e-01 | 0.649 | 0 | 0 |
| Translesion synthesis by REV1 | R-HSA-110312 | 2.244011e-01 | 0.649 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 2.514598e-01 | 0.600 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 2.981007e-01 | 0.526 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 2.981007e-01 | 0.526 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 2.981007e-01 | 0.526 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | R-HSA-2892245 | 3.629672e-01 | 0.440 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 3.629672e-01 | 0.440 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 3.629672e-01 | 0.440 | 0 | 0 |
| Nef Mediated CD4 Down-regulation | R-HSA-167590 | 3.629672e-01 | 0.440 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 3.629672e-01 | 0.440 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 3.629672e-01 | 0.440 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 3.629672e-01 | 0.440 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 3.629672e-01 | 0.440 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | R-HSA-2892247 | 2.791485e-01 | 0.554 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 2.791485e-01 | 0.554 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 2.791485e-01 | 0.554 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 2.791485e-01 | 0.554 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 3.325048e-01 | 0.478 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 3.325048e-01 | 0.478 | 0 | 0 |
| SHC-related events triggered by IGF1R | R-HSA-2428933 | 3.325048e-01 | 0.478 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 3.325048e-01 | 0.478 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 2.617328e-01 | 0.582 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 2.458951e-01 | 0.609 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 2.458951e-01 | 0.609 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 3.072801e-01 | 0.512 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 4.076310e-01 | 0.390 | 0 | 0 |
| Nef mediated downregulation of MHC class I complex cell surface expression | R-HSA-164940 | 4.076310e-01 | 0.390 | 0 | 0 |
| Activation of RAS in B cells | R-HSA-1169092 | 4.076310e-01 | 0.390 | 0 | 0 |
| Regulation of NPAS4 mRNA translation | R-HSA-9768778 | 4.076310e-01 | 0.390 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 4.076310e-01 | 0.390 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 4.076310e-01 | 0.390 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 2.668899e-01 | 0.574 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 3.668410e-01 | 0.436 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 2.501442e-01 | 0.602 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 3.101126e-01 | 0.508 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 3.347619e-01 | 0.475 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 3.347619e-01 | 0.475 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 3.347619e-01 | 0.475 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 3.641697e-01 | 0.439 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 4.008578e-01 | 0.397 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 4.008578e-01 | 0.397 | 0 | 0 |
| Regulation of PD-L1(CD274) translation | R-HSA-9909620 | 3.926056e-01 | 0.406 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 4.343381e-01 | 0.362 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 4.343381e-01 | 0.362 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 3.844222e-01 | 0.415 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 3.205063e-01 | 0.494 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 3.765992e-01 | 0.424 | 0 | 0 |
| SHC-mediated cascade:FGFR3 | R-HSA-5654704 | 4.208423e-01 | 0.376 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 4.208423e-01 | 0.376 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 2.614081e-01 | 0.583 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 3.491019e-01 | 0.457 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 3.491019e-01 | 0.457 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 2.327633e-01 | 0.633 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 2.197744e-01 | 0.658 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 4.338864e-01 | 0.363 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 4.212111e-01 | 0.376 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 4.212111e-01 | 0.376 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 2.643492e-01 | 0.578 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 4.304574e-01 | 0.366 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 2.247308e-01 | 0.648 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 2.254088e-01 | 0.647 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 4.304574e-01 | 0.366 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 2.857310e-01 | 0.544 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 2.302697e-01 | 0.638 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 3.356762e-01 | 0.474 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 3.285840e-01 | 0.483 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 4.212111e-01 | 0.376 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 2.668899e-01 | 0.574 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 4.144565e-01 | 0.383 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 2.382368e-01 | 0.623 | 0 | 0 |
| Transcriptional regulation of testis differentiation | R-HSA-9690406 | 2.791485e-01 | 0.554 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 2.879133e-01 | 0.541 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 3.353400e-01 | 0.475 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 3.120211e-01 | 0.506 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 4.107204e-01 | 0.386 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 2.981007e-01 | 0.526 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 2.198016e-01 | 0.658 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 2.791485e-01 | 0.554 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 2.531089e-01 | 0.597 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 4.343381e-01 | 0.362 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 4.343381e-01 | 0.362 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 2.234436e-01 | 0.651 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 2.914317e-01 | 0.535 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 4.063381e-01 | 0.391 | 0 | 0 |
| Interleukin-15 signaling | R-HSA-8983432 | 3.325048e-01 | 0.478 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 2.214089e-01 | 0.655 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 2.214089e-01 | 0.655 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 3.356762e-01 | 0.474 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 3.356762e-01 | 0.474 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 2.237913e-01 | 0.650 | 0 | 0 |
| Formation of lateral plate mesoderm | R-HSA-9758920 | 2.704792e-01 | 0.568 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 2.704792e-01 | 0.568 | 0 | 0 |
| Toxicity of botulinum toxin type E (botE) | R-HSA-5250992 | 2.704792e-01 | 0.568 | 0 | 0 |
| POLB-Dependent Long Patch Base Excision Repair | R-HSA-110362 | 2.981007e-01 | 0.526 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 3.629672e-01 | 0.440 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 3.668410e-01 | 0.436 | 0 | 0 |
| Lysosphingolipid and LPA receptors | R-HSA-419408 | 4.343381e-01 | 0.362 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 4.208423e-01 | 0.376 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 3.274458e-01 | 0.485 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 3.224208e-01 | 0.492 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 2.692562e-01 | 0.570 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 3.844222e-01 | 0.415 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 3.412779e-01 | 0.467 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 3.542964e-01 | 0.451 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 3.896115e-01 | 0.409 | 0 | 0 |
| Passive transport by Aquaporins | R-HSA-432047 | 2.791485e-01 | 0.554 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 3.641697e-01 | 0.439 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 2.524168e-01 | 0.598 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 4.343381e-01 | 0.362 | 0 | 0 |
| Telomere C-strand synthesis initiation | R-HSA-174430 | 4.343381e-01 | 0.362 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 12 | R-HSA-392170 | 4.208423e-01 | 0.376 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 4.063381e-01 | 0.391 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 2.857310e-01 | 0.544 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 2.243313e-01 | 0.649 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 2.524168e-01 | 0.598 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 3.464868e-01 | 0.460 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 3.844222e-01 | 0.415 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 3.325048e-01 | 0.478 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 4.304574e-01 | 0.366 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 2.296838e-01 | 0.639 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 2.514598e-01 | 0.600 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 2.302697e-01 | 0.638 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 2.692562e-01 | 0.570 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 2.639152e-01 | 0.579 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 2.514598e-01 | 0.600 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 2.204501e-01 | 0.657 | 0 | 0 |
| Post-transcriptional silencing by small RNAs | R-HSA-426496 | 2.237913e-01 | 0.650 | 0 | 0 |
| Abacavir transmembrane transport | R-HSA-2161517 | 3.170864e-01 | 0.499 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 3.629672e-01 | 0.440 | 0 | 0 |
| mRNA Editing: C to U Conversion | R-HSA-72200 | 3.629672e-01 | 0.440 | 0 | 0 |
| FGFR1c ligand binding and activation | R-HSA-190373 | 3.668410e-01 | 0.436 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 3.542964e-01 | 0.451 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 2.172411e-01 | 0.663 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 3.127891e-01 | 0.505 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 3.316245e-01 | 0.479 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 3.890940e-01 | 0.410 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 3.246038e-01 | 0.489 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 2.303642e-01 | 0.638 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 2.243313e-01 | 0.649 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 2.357858e-01 | 0.627 | 0 | 0 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 2.791485e-01 | 0.554 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 3.989280e-01 | 0.399 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 2.857310e-01 | 0.544 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 2.531691e-01 | 0.597 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 2.531691e-01 | 0.597 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 2.584154e-01 | 0.588 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 2.302697e-01 | 0.638 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 2.244011e-01 | 0.649 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 3.072801e-01 | 0.512 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 2.314669e-01 | 0.636 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 2.669497e-01 | 0.574 | 0 | 0 |
| p38MAPK events | R-HSA-171007 | 4.343381e-01 | 0.362 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 2.236144e-01 | 0.651 | 0 | 0 |
| PTK6 Regulates Proteins Involved in RNA Processing | R-HSA-8849468 | 2.237913e-01 | 0.650 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 4.100554e-01 | 0.387 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 3.246038e-01 | 0.489 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 3.354812e-01 | 0.474 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 2.174619e-01 | 0.663 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 3.307160e-01 | 0.481 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 3.233367e-01 | 0.490 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 2.243313e-01 | 0.649 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 2.174619e-01 | 0.663 | 0 | 0 |
| Interleukin-9 signaling | R-HSA-8985947 | 4.076310e-01 | 0.390 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 3.668410e-01 | 0.436 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 3.085380e-01 | 0.511 | 0 | 0 |
| Inhibition of PKR | R-HSA-169131 | 2.245053e-01 | 0.649 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH2 | R-HSA-5632928 | 3.170906e-01 | 0.499 | 0 | 0 |
| Acetylcholine inhibits contraction of outer hair cells | R-HSA-9667769 | 2.704792e-01 | 0.568 | 0 | 0 |
| Formation of the Editosome | R-HSA-75094 | 2.704792e-01 | 0.568 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 3.986270e-01 | 0.399 | 0 | 0 |
| Defective ABCC8 can cause hypo- and hyper-glycemias | R-HSA-5683177 | 3.986270e-01 | 0.399 | 0 | 0 |
| TGFBR3 regulates TGF-beta signaling | R-HSA-9839389 | 3.629672e-01 | 0.440 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 2.791485e-01 | 0.554 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 3.325048e-01 | 0.478 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 2.617328e-01 | 0.582 | 0 | 0 |
| Negative regulation of activity of TFAP2 (AP-2) family transcription factors | R-HSA-8866904 | 4.076310e-01 | 0.390 | 0 | 0 |
| Co-stimulation by ICOS | R-HSA-9927354 | 4.076310e-01 | 0.390 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 3.668410e-01 | 0.436 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 3.356762e-01 | 0.474 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 2.523252e-01 | 0.598 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 2.523252e-01 | 0.598 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 2.370987e-01 | 0.625 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 3.347619e-01 | 0.475 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 3.347619e-01 | 0.475 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 3.061620e-01 | 0.514 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 2.556850e-01 | 0.592 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 3.036011e-01 | 0.518 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 4.338864e-01 | 0.363 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 3.521247e-01 | 0.453 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 2.799488e-01 | 0.553 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 4.269711e-01 | 0.370 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 3.347619e-01 | 0.475 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 2.214089e-01 | 0.655 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 3.621466e-01 | 0.441 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 2.302697e-01 | 0.638 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 4.269711e-01 | 0.370 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 2.244011e-01 | 0.649 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 2.244011e-01 | 0.649 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 3.731307e-01 | 0.428 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 4.142512e-01 | 0.383 | 0 | 0 |
| Activated NTRK2 signals through FYN | R-HSA-9032500 | 4.076310e-01 | 0.390 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 3.991709e-01 | 0.399 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 4.142512e-01 | 0.383 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 4.142512e-01 | 0.383 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 2.668899e-01 | 0.574 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 3.170864e-01 | 0.499 | 0 | 0 |
| Lipid particle organization | R-HSA-8964572 | 3.170864e-01 | 0.499 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 3.325048e-01 | 0.478 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 3.325048e-01 | 0.478 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 3.325048e-01 | 0.478 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 4.208423e-01 | 0.376 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 3.926056e-01 | 0.406 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 3.320948e-01 | 0.479 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 3.651709e-01 | 0.438 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 4.343381e-01 | 0.362 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 2.480818e-01 | 0.605 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 2.933343e-01 | 0.533 | 0 | 0 |
| DSCAM interactions | R-HSA-376172 | 3.986270e-01 | 0.399 | 0 | 0 |
| Tandem pore domain potassium channels | R-HSA-1296346 | 2.302697e-01 | 0.638 | 0 | 0 |
| Alpha-defensins | R-HSA-1462054 | 4.076310e-01 | 0.390 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 2.692562e-01 | 0.570 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 3.844222e-01 | 0.415 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 3.488181e-01 | 0.457 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 3.908689e-01 | 0.408 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 2.762725e-01 | 0.559 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 2.895955e-01 | 0.538 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 2.212895e-01 | 0.655 | 0 | 0 |
| Formation of the anterior neural plate | R-HSA-9823739 | 4.343381e-01 | 0.362 | 0 | 0 |
| NrCAM interactions | R-HSA-447038 | 2.237913e-01 | 0.650 | 0 | 0 |
| Co-inhibition by BTLA | R-HSA-9927353 | 2.237913e-01 | 0.650 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 3.986270e-01 | 0.399 | 0 | 0 |
| Interleukin-18 signaling | R-HSA-9012546 | 4.076310e-01 | 0.390 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 2.699516e-01 | 0.569 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 3.641697e-01 | 0.439 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 3.641697e-01 | 0.439 | 0 | 0 |
| Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | R-HSA-2660825 | 2.704792e-01 | 0.568 | 0 | 0 |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | R-HSA-2660826 | 2.704792e-01 | 0.568 | 0 | 0 |
| Leukotriene receptors | R-HSA-391906 | 3.170864e-01 | 0.499 | 0 | 0 |
| Eicosanoid ligand-binding receptors | R-HSA-391903 | 3.926056e-01 | 0.406 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 4.343381e-01 | 0.362 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 4.208423e-01 | 0.376 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 3.668410e-01 | 0.436 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 4.379228e-01 | 0.359 | 0 | 0 |
| SHC-mediated cascade:FGFR4 | R-HSA-5654719 | 4.487516e-01 | 0.348 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 4.487516e-01 | 0.348 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 4.487516e-01 | 0.348 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 4.507145e-01 | 0.346 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 4.507145e-01 | 0.346 | 0 | 0 |
| 5-Phosphoribose 1-diphosphate biosynthesis | R-HSA-73843 | 4.507145e-01 | 0.346 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 4.507145e-01 | 0.346 | 0 | 0 |
| Toxicity of botulinum toxin type A (botA) | R-HSA-5250968 | 4.507145e-01 | 0.346 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 4.507145e-01 | 0.346 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 4.507145e-01 | 0.346 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 4.507145e-01 | 0.346 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 4.507145e-01 | 0.346 | 0 | 0 |
| MAPK1 (ERK2) activation | R-HSA-112411 | 4.507145e-01 | 0.346 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 4.527596e-01 | 0.344 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 4.541140e-01 | 0.343 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 4.580383e-01 | 0.339 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 4.582191e-01 | 0.339 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 4.583155e-01 | 0.339 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 4.583155e-01 | 0.339 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 4.583155e-01 | 0.339 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 4.583155e-01 | 0.339 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 4.638217e-01 | 0.334 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 4.638217e-01 | 0.334 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 4.653733e-01 | 0.332 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 4.653733e-01 | 0.332 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 4.653733e-01 | 0.332 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 4.670976e-01 | 0.331 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 4.670976e-01 | 0.331 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 4.670976e-01 | 0.331 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 4.670976e-01 | 0.331 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 4.670976e-01 | 0.331 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 4.670976e-01 | 0.331 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 4.670976e-01 | 0.331 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 4.682677e-01 | 0.330 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of other transcription factors | R-HSA-8866906 | 4.704324e-01 | 0.328 | 0 | 0 |
| Defective ABCA1 causes TGD | R-HSA-5682113 | 4.704324e-01 | 0.328 | 0 | 0 |
| Invadopodia formation | R-HSA-8941237 | 4.704324e-01 | 0.328 | 0 | 0 |
| Classical Kir channels | R-HSA-1296053 | 4.704324e-01 | 0.328 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 4.704324e-01 | 0.328 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 4.704324e-01 | 0.328 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 4.704324e-01 | 0.328 | 0 | 0 |
| Defective GCLC causes HAGGSD | R-HSA-5578999 | 4.704324e-01 | 0.328 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 4.704324e-01 | 0.328 | 0 | 0 |
| Diseases of Mismatch Repair (MMR) | R-HSA-5423599 | 4.704324e-01 | 0.328 | 0 | 0 |
| Histamine receptors | R-HSA-390650 | 4.704324e-01 | 0.328 | 0 | 0 |
| Regulation of MITF-M dependent genes involved in metabolism | R-HSA-9854907 | 4.704324e-01 | 0.328 | 0 | 0 |
| FasL/ CD95L signaling | R-HSA-75157 | 4.704324e-01 | 0.328 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 4.709305e-01 | 0.327 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 4.710656e-01 | 0.327 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 4.762195e-01 | 0.322 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 4.824342e-01 | 0.317 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 4.824342e-01 | 0.317 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 4.824342e-01 | 0.317 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 4.919586e-01 | 0.308 | 0 | 0 |
| DNA replication initiation | R-HSA-68952 | 4.919586e-01 | 0.308 | 0 | 0 |
| Activation of Ca-permeable Kainate Receptor | R-HSA-451308 | 4.919586e-01 | 0.308 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 4.919586e-01 | 0.308 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 4.919586e-01 | 0.308 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 4.919586e-01 | 0.308 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 4.919586e-01 | 0.308 | 0 | 0 |
| MAPK3 (ERK1) activation | R-HSA-110056 | 4.919586e-01 | 0.308 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 4.919586e-01 | 0.308 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 4.930304e-01 | 0.307 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 4.953551e-01 | 0.305 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 4.989833e-01 | 0.302 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 4.989833e-01 | 0.302 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 4.992157e-01 | 0.302 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 5.024876e-01 | 0.299 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 5.035291e-01 | 0.298 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 5.061711e-01 | 0.296 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 5.106496e-01 | 0.292 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 5.106496e-01 | 0.292 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 5.106496e-01 | 0.292 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 5.124508e-01 | 0.290 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 5.125506e-01 | 0.290 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 5.149948e-01 | 0.288 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 5.226410e-01 | 0.282 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 5.236330e-01 | 0.281 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 5.281018e-01 | 0.277 | 0 | 0 |
| SHC-mediated cascade:FGFR1 | R-HSA-5654688 | 5.294432e-01 | 0.276 | 0 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 5.294432e-01 | 0.276 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 5.294617e-01 | 0.276 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 5.297214e-01 | 0.276 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 5.298706e-01 | 0.276 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 5.311882e-01 | 0.275 | 0 | 0 |
| Regulation of CDH11 mRNA translation by microRNAs | R-HSA-9759811 | 5.311882e-01 | 0.275 | 0 | 0 |
| Activated NTRK3 signals through RAS | R-HSA-9034864 | 5.311882e-01 | 0.275 | 0 | 0 |
| FGFR2b ligand binding and activation | R-HSA-190377 | 5.311882e-01 | 0.275 | 0 | 0 |
| Presynaptic depolarization and calcium channel opening | R-HSA-112308 | 5.311882e-01 | 0.275 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 5.311882e-01 | 0.275 | 0 | 0 |
| Formation of the posterior neural plate | R-HSA-9832991 | 5.311882e-01 | 0.275 | 0 | 0 |
| Ionotropic activity of kainate receptors | R-HSA-451306 | 5.311882e-01 | 0.275 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 5.311882e-01 | 0.275 | 0 | 0 |
| SARS-CoV-2 modulates autophagy | R-HSA-9754560 | 5.311882e-01 | 0.275 | 0 | 0 |
| Transport of RCbl within the body | R-HSA-9758890 | 5.311882e-01 | 0.275 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 5.311882e-01 | 0.275 | 0 | 0 |
| Prostanoid ligand receptors | R-HSA-391908 | 5.311882e-01 | 0.275 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 5.336679e-01 | 0.273 | 0 | 0 |
| Drug-mediated inhibition of CDK4/CDK6 activity | R-HSA-9754119 | 5.336679e-01 | 0.273 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 5.336679e-01 | 0.273 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 5.336679e-01 | 0.273 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 5.336679e-01 | 0.273 | 0 | 0 |
| Alanine metabolism | R-HSA-8964540 | 5.336679e-01 | 0.273 | 0 | 0 |
| Transmission across Electrical Synapses | R-HSA-112307 | 5.336679e-01 | 0.273 | 0 | 0 |
| Electric Transmission Across Gap Junctions | R-HSA-112303 | 5.336679e-01 | 0.273 | 0 | 0 |
| MDK and PTN in ALK signaling | R-HSA-9851151 | 5.336679e-01 | 0.273 | 0 | 0 |
| p75NTR negatively regulates cell cycle via SC1 | R-HSA-193670 | 5.336679e-01 | 0.273 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 5.336679e-01 | 0.273 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 5.476848e-01 | 0.261 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 5.476848e-01 | 0.261 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 5.496354e-01 | 0.260 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 5.496354e-01 | 0.260 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 5.496354e-01 | 0.260 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 5.504619e-01 | 0.259 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 5.504619e-01 | 0.259 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 5.504619e-01 | 0.259 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 5.504619e-01 | 0.259 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 5.504619e-01 | 0.259 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 5.504619e-01 | 0.259 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 5.522495e-01 | 0.258 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 5.522495e-01 | 0.258 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 5.522495e-01 | 0.258 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 5.529168e-01 | 0.257 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 5.550382e-01 | 0.256 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 5.550382e-01 | 0.256 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 5.596611e-01 | 0.252 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 5.596611e-01 | 0.252 | 0 | 0 |
| FGFR1 ligand binding and activation | R-HSA-190242 | 5.596611e-01 | 0.252 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 5.596611e-01 | 0.252 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 5.596611e-01 | 0.252 | 0 | 0 |
| Tie2 Signaling | R-HSA-210993 | 5.596611e-01 | 0.252 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 5.602912e-01 | 0.252 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 5.604166e-01 | 0.251 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 5.618658e-01 | 0.250 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 5.646080e-01 | 0.248 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 5.661152e-01 | 0.247 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 5.681029e-01 | 0.246 | 0 | 0 |
| Presynaptic nicotinic acetylcholine receptors | R-HSA-622323 | 5.682965e-01 | 0.245 | 0 | 0 |
| Activated NTRK2 signals through RAS | R-HSA-9026519 | 5.682965e-01 | 0.245 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 5.682965e-01 | 0.245 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 5.682965e-01 | 0.245 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 5.682965e-01 | 0.245 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 5.682965e-01 | 0.245 | 0 | 0 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | R-HSA-113501 | 5.682965e-01 | 0.245 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 5.682965e-01 | 0.245 | 0 | 0 |
| Signaling by activated point mutants of FGFR1 | R-HSA-1839122 | 5.682965e-01 | 0.245 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 5.682965e-01 | 0.245 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 5.682965e-01 | 0.245 | 0 | 0 |
| Reduction of cytosolic Ca++ levels | R-HSA-418359 | 5.682965e-01 | 0.245 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 5.705874e-01 | 0.244 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 5.744850e-01 | 0.241 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 5.744850e-01 | 0.241 | 0 | 0 |
| Heme degradation | R-HSA-189483 | 5.744850e-01 | 0.241 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 5.798688e-01 | 0.237 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 5.798688e-01 | 0.237 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 5.798688e-01 | 0.237 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 5.817521e-01 | 0.235 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 5.834188e-01 | 0.234 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 5.882802e-01 | 0.230 | 0 | 0 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 5.882802e-01 | 0.230 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 5.885150e-01 | 0.230 | 0 | 0 |
| Activation of AMPA receptors | R-HSA-399710 | 5.893556e-01 | 0.230 | 0 | 0 |
| IRS activation | R-HSA-74713 | 5.893556e-01 | 0.230 | 0 | 0 |
| NOSIP mediated eNOS trafficking | R-HSA-203754 | 5.893556e-01 | 0.230 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 5.893556e-01 | 0.230 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 5.893556e-01 | 0.230 | 0 | 0 |
| Defective SLC1A3 causes episodic ataxia 6 (EA6) | R-HSA-5619062 | 5.893556e-01 | 0.230 | 0 | 0 |
| Activation of AKT2 | R-HSA-165158 | 5.893556e-01 | 0.230 | 0 | 0 |
| Trafficking of myristoylated proteins to the cilium | R-HSA-5624138 | 5.893556e-01 | 0.230 | 0 | 0 |
| Suppression of autophagy | R-HSA-9636569 | 5.893556e-01 | 0.230 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 5.893556e-01 | 0.230 | 0 | 0 |
| Muscarinic acetylcholine receptors | R-HSA-390648 | 5.893556e-01 | 0.230 | 0 | 0 |
| Biosynthesis of DPAn-3-derived 13-series resolvins | R-HSA-9026403 | 5.893556e-01 | 0.230 | 0 | 0 |
| Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | R-HSA-9931529 | 5.893556e-01 | 0.230 | 0 | 0 |
| RUNX2 regulates chondrocyte maturation | R-HSA-8941284 | 5.893556e-01 | 0.230 | 0 | 0 |
| Toxicity of botulinum toxin type C (botC) | R-HSA-5250971 | 5.893556e-01 | 0.230 | 0 | 0 |
| Nectin/Necl trans heterodimerization | R-HSA-420597 | 5.893556e-01 | 0.230 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 5.906312e-01 | 0.229 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 5.906312e-01 | 0.229 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 5.942782e-01 | 0.226 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 5.961258e-01 | 0.225 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 5.961258e-01 | 0.225 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 6.032307e-01 | 0.220 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 6.032307e-01 | 0.220 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 6.032307e-01 | 0.220 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 6.032307e-01 | 0.220 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 6.032307e-01 | 0.220 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 6.032307e-01 | 0.220 | 0 | 0 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 6.032307e-01 | 0.220 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 6.032307e-01 | 0.220 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 6.038849e-01 | 0.219 | 0 | 0 |
| SHC-mediated cascade:FGFR2 | R-HSA-5654699 | 6.038849e-01 | 0.219 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 6.038849e-01 | 0.219 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 6.038849e-01 | 0.219 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 6.038849e-01 | 0.219 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 6.045996e-01 | 0.219 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 6.063957e-01 | 0.217 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 6.093048e-01 | 0.215 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 6.107406e-01 | 0.214 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 6.156741e-01 | 0.211 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 6.156741e-01 | 0.211 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 6.156741e-01 | 0.211 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 6.156741e-01 | 0.211 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 6.156741e-01 | 0.211 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 6.171363e-01 | 0.210 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 6.171363e-01 | 0.210 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 6.171363e-01 | 0.210 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 6.171363e-01 | 0.210 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 6.205349e-01 | 0.207 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 6.270473e-01 | 0.203 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 6.270473e-01 | 0.203 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 6.270473e-01 | 0.203 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 6.311132e-01 | 0.200 | 0 | 0 |
| Acetylcholine binding and downstream events | R-HSA-181431 | 6.359808e-01 | 0.197 | 0 | 0 |
| Adenylate cyclase activating pathway | R-HSA-170660 | 6.359808e-01 | 0.197 | 0 | 0 |
| Postsynaptic nicotinic acetylcholine receptors | R-HSA-622327 | 6.359808e-01 | 0.197 | 0 | 0 |
| FGFR2c ligand binding and activation | R-HSA-190375 | 6.359808e-01 | 0.197 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 6.359808e-01 | 0.197 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 6.359808e-01 | 0.197 | 0 | 0 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | R-HSA-5676594 | 6.359808e-01 | 0.197 | 0 | 0 |
| FGFR4 ligand binding and activation | R-HSA-190322 | 6.359808e-01 | 0.197 | 0 | 0 |
| Signaling by activated point mutants of FGFR3 | R-HSA-1839130 | 6.359808e-01 | 0.197 | 0 | 0 |
| FGFR3 mutant receptor activation | R-HSA-2033514 | 6.359808e-01 | 0.197 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 6.374875e-01 | 0.196 | 0 | 0 |
| Plus-strand DNA synthesis | R-HSA-164525 | 6.383962e-01 | 0.195 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 6.383962e-01 | 0.195 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 6.383962e-01 | 0.195 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 6.383962e-01 | 0.195 | 0 | 0 |
| Inhibition of Signaling by Overexpressed EGFR | R-HSA-5638303 | 6.383962e-01 | 0.195 | 0 | 0 |
| Signaling by Overexpressed Wild-Type EGFR in Cancer | R-HSA-5638302 | 6.383962e-01 | 0.195 | 0 | 0 |
| Phase 1 - inactivation of fast Na+ channels | R-HSA-5576894 | 6.383962e-01 | 0.195 | 0 | 0 |
| Signaling by MST1 | R-HSA-8852405 | 6.383962e-01 | 0.195 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 6.383962e-01 | 0.195 | 0 | 0 |
| Pentose phosphate pathway disease | R-HSA-6791465 | 6.383962e-01 | 0.195 | 0 | 0 |
| NGF-independant TRKA activation | R-HSA-187024 | 6.383962e-01 | 0.195 | 0 | 0 |
| CDC6 association with the ORC:origin complex | R-HSA-68689 | 6.383962e-01 | 0.195 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 6.383962e-01 | 0.195 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 6.383962e-01 | 0.195 | 0 | 0 |
| Ceramide signalling | R-HSA-193681 | 6.383962e-01 | 0.195 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 6.383962e-01 | 0.195 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 6.383962e-01 | 0.195 | 0 | 0 |
| Release of apoptotic factors from the mitochondria | R-HSA-111457 | 6.383962e-01 | 0.195 | 0 | 0 |
| Release of Hh-Np from the secreting cell | R-HSA-5362798 | 6.383962e-01 | 0.195 | 0 | 0 |
| TYSND1 cleaves peroxisomal proteins | R-HSA-9033500 | 6.383962e-01 | 0.195 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 6.394096e-01 | 0.194 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 6.394096e-01 | 0.194 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 6.418078e-01 | 0.193 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 6.418078e-01 | 0.193 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 6.418078e-01 | 0.193 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 6.437423e-01 | 0.191 | 0 | 0 |
| Protein folding | R-HSA-391251 | 6.440291e-01 | 0.191 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 6.491057e-01 | 0.188 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 6.491057e-01 | 0.188 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 6.491057e-01 | 0.188 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 6.493263e-01 | 0.188 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 6.546012e-01 | 0.184 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 6.561329e-01 | 0.183 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 6.569044e-01 | 0.182 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 6.571562e-01 | 0.182 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 6.580949e-01 | 0.182 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 6.645588e-01 | 0.177 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 6.648868e-01 | 0.177 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 6.648868e-01 | 0.177 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 6.656913e-01 | 0.177 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 6.665702e-01 | 0.176 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 6.665702e-01 | 0.176 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 6.665702e-01 | 0.176 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 6.665702e-01 | 0.176 | 0 | 0 |
| FGFR3c ligand binding and activation | R-HSA-190372 | 6.665702e-01 | 0.176 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 6.665702e-01 | 0.176 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 6.665702e-01 | 0.176 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 6.665702e-01 | 0.176 | 0 | 0 |
| FRS-mediated FGFR3 signaling | R-HSA-5654706 | 6.666623e-01 | 0.176 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 6.666623e-01 | 0.176 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 6.666623e-01 | 0.176 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 6.707015e-01 | 0.173 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 6.707015e-01 | 0.173 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 6.707015e-01 | 0.173 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 6.707015e-01 | 0.173 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 6.707015e-01 | 0.173 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 6.724967e-01 | 0.172 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 6.761249e-01 | 0.170 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 6.788010e-01 | 0.168 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 6.795978e-01 | 0.168 | 0 | 0 |
| Autointegration results in viral DNA circles | R-HSA-177539 | 6.815827e-01 | 0.166 | 0 | 0 |
| Uncoating of the HIV Virion | R-HSA-162585 | 6.815827e-01 | 0.166 | 0 | 0 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 6.815827e-01 | 0.166 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 6.815827e-01 | 0.166 | 0 | 0 |
| Toxicity of botulinum toxin type F (botF) | R-HSA-5250981 | 6.815827e-01 | 0.166 | 0 | 0 |
| Toxicity of botulinum toxin type D (botD) | R-HSA-5250955 | 6.815827e-01 | 0.166 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 6.815827e-01 | 0.166 | 0 | 0 |
| Intracellular metabolism of fatty acids regulates insulin secretion | R-HSA-434313 | 6.815827e-01 | 0.166 | 0 | 0 |
| Integration of viral DNA into host genomic DNA | R-HSA-175567 | 6.815827e-01 | 0.166 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 6.815827e-01 | 0.166 | 0 | 0 |
| NADPH regeneration | R-HSA-389542 | 6.815827e-01 | 0.166 | 0 | 0 |
| Small interfering RNA (siRNA) biogenesis | R-HSA-426486 | 6.815827e-01 | 0.166 | 0 | 0 |
| VLDL assembly | R-HSA-8866423 | 6.815827e-01 | 0.166 | 0 | 0 |
| Neurofascin interactions | R-HSA-447043 | 6.815827e-01 | 0.166 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 6.818680e-01 | 0.166 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 6.820592e-01 | 0.166 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 6.881436e-01 | 0.162 | 0 | 0 |
| FRS-mediated FGFR4 signaling | R-HSA-5654712 | 6.902329e-01 | 0.161 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 6.902329e-01 | 0.161 | 0 | 0 |
| Regulation of IFNA/IFNB signaling | R-HSA-912694 | 6.902329e-01 | 0.161 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 6.902329e-01 | 0.161 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 6.911606e-01 | 0.160 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 6.911606e-01 | 0.160 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 6.914685e-01 | 0.160 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 6.942129e-01 | 0.159 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 6.943816e-01 | 0.158 | 0 | 0 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | R-HSA-8948700 | 6.950478e-01 | 0.158 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 6.950478e-01 | 0.158 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 6.950478e-01 | 0.158 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 6.950478e-01 | 0.158 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 6.950478e-01 | 0.158 | 0 | 0 |
| FGFR3 ligand binding and activation | R-HSA-190239 | 6.950478e-01 | 0.158 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 6.950478e-01 | 0.158 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 6.981585e-01 | 0.156 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 7.009023e-01 | 0.154 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 7.034104e-01 | 0.153 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 7.034104e-01 | 0.153 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 7.034104e-01 | 0.153 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 7.119189e-01 | 0.148 | 0 | 0 |
| Free fatty acids regulate insulin secretion | R-HSA-400451 | 7.125265e-01 | 0.147 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 7.125265e-01 | 0.147 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 7.125265e-01 | 0.147 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 7.134614e-01 | 0.147 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 7.181751e-01 | 0.144 | 0 | 0 |
| RUNX1 regulates estrogen receptor mediated transcription | R-HSA-8931987 | 7.196136e-01 | 0.143 | 0 | 0 |
| NOSTRIN mediated eNOS trafficking | R-HSA-203641 | 7.196136e-01 | 0.143 | 0 | 0 |
| PP2A-mediated dephosphorylation of key metabolic factors | R-HSA-163767 | 7.196136e-01 | 0.143 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 7.196136e-01 | 0.143 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 7.196136e-01 | 0.143 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | R-HSA-9031525 | 7.196136e-01 | 0.143 | 0 | 0 |
| FGFR3b ligand binding and activation | R-HSA-190371 | 7.196136e-01 | 0.143 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 7.196136e-01 | 0.143 | 0 | 0 |
| LDL remodeling | R-HSA-8964041 | 7.196136e-01 | 0.143 | 0 | 0 |
| Synthesis of PIPs in the nucleus | R-HSA-8847453 | 7.196136e-01 | 0.143 | 0 | 0 |
| Activation of TRKA receptors | R-HSA-187015 | 7.196136e-01 | 0.143 | 0 | 0 |
| Phase 3 - rapid repolarisation | R-HSA-5576890 | 7.196136e-01 | 0.143 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 7.196136e-01 | 0.143 | 0 | 0 |
| Induction of Cell-Cell Fusion | R-HSA-9733458 | 7.214817e-01 | 0.142 | 0 | 0 |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | R-HSA-434316 | 7.214817e-01 | 0.142 | 0 | 0 |
| Attachment and Entry | R-HSA-9678110 | 7.214817e-01 | 0.142 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 7.214817e-01 | 0.142 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 7.214817e-01 | 0.142 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 7.214817e-01 | 0.142 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 7.214817e-01 | 0.142 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 7.214817e-01 | 0.142 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 7.214817e-01 | 0.142 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 7.249617e-01 | 0.140 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 7.249617e-01 | 0.140 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 7.287339e-01 | 0.137 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 7.292625e-01 | 0.137 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 7.292625e-01 | 0.137 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 7.293173e-01 | 0.137 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 7.317315e-01 | 0.136 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 7.324338e-01 | 0.135 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 7.335602e-01 | 0.135 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 7.335602e-01 | 0.135 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 7.383481e-01 | 0.132 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 7.437294e-01 | 0.129 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 7.448276e-01 | 0.128 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 7.448276e-01 | 0.128 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 7.448276e-01 | 0.128 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 7.459538e-01 | 0.127 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 7.459538e-01 | 0.127 | 0 | 0 |
| Phase 2 - plateau phase | R-HSA-5576893 | 7.459538e-01 | 0.127 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 7.459538e-01 | 0.127 | 0 | 0 |
| Synthesis of PG | R-HSA-1483148 | 7.459538e-01 | 0.127 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 7.461843e-01 | 0.127 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 7.461843e-01 | 0.127 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 7.461843e-01 | 0.127 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 7.470236e-01 | 0.127 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 7.480092e-01 | 0.126 | 0 | 0 |
| Reverse Transcription of HIV RNA | R-HSA-162589 | 7.531041e-01 | 0.123 | 0 | 0 |
| Minus-strand DNA synthesis | R-HSA-164516 | 7.531041e-01 | 0.123 | 0 | 0 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 7.531041e-01 | 0.123 | 0 | 0 |
| Highly calcium permeable nicotinic acetylcholine receptors | R-HSA-629597 | 7.531041e-01 | 0.123 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 7.531041e-01 | 0.123 | 0 | 0 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | 7.531041e-01 | 0.123 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 7.531041e-01 | 0.123 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 7.531041e-01 | 0.123 | 0 | 0 |
| Neurotransmitter uptake and metabolism In glial cells | R-HSA-112313 | 7.531041e-01 | 0.123 | 0 | 0 |
| Astrocytic Glutamate-Glutamine Uptake And Metabolism | R-HSA-210455 | 7.531041e-01 | 0.123 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 7.531041e-01 | 0.123 | 0 | 0 |
| Interleukin-23 signaling | R-HSA-9020933 | 7.531041e-01 | 0.123 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 7.533596e-01 | 0.123 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 7.533596e-01 | 0.123 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 7.533596e-01 | 0.123 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 7.533596e-01 | 0.123 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 7.533596e-01 | 0.123 | 1 | 1 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 7.533596e-01 | 0.123 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 7.533596e-01 | 0.123 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 7.533596e-01 | 0.123 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 7.533596e-01 | 0.123 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 7.539055e-01 | 0.123 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 7.590687e-01 | 0.120 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 7.594266e-01 | 0.120 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 7.638299e-01 | 0.117 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 7.685555e-01 | 0.114 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 7.685555e-01 | 0.114 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 7.685555e-01 | 0.114 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 7.685555e-01 | 0.114 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 7.685555e-01 | 0.114 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 7.685555e-01 | 0.114 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 7.685555e-01 | 0.114 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 7.721627e-01 | 0.112 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 7.726904e-01 | 0.112 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 7.739675e-01 | 0.111 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 7.825349e-01 | 0.106 | 0 | 0 |
| Estrogen-stimulated signaling through PRKCZ | R-HSA-9634635 | 7.825962e-01 | 0.106 | 0 | 0 |
| Interleukin-21 signaling | R-HSA-9020958 | 7.825962e-01 | 0.106 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 7.825962e-01 | 0.106 | 0 | 0 |
| APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | R-HSA-5649702 | 7.825962e-01 | 0.106 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 7.825962e-01 | 0.106 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 7.825962e-01 | 0.106 | 0 | 0 |
| Regulation of NPAS4 gene transcription | R-HSA-9768777 | 7.825962e-01 | 0.106 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 7.825962e-01 | 0.106 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 7.825962e-01 | 0.106 | 0 | 0 |
| Butyrophilin (BTN) family interactions | R-HSA-8851680 | 7.825962e-01 | 0.106 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 7.848894e-01 | 0.105 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 7.857272e-01 | 0.105 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 7.887271e-01 | 0.103 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 7.888430e-01 | 0.103 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 7.893843e-01 | 0.103 | 0 | 0 |
| Activated point mutants of FGFR2 | R-HSA-2033519 | 7.893843e-01 | 0.103 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 7.893843e-01 | 0.103 | 0 | 0 |
| Vitamin D (calciferol) metabolism | R-HSA-196791 | 7.893843e-01 | 0.103 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 7.893843e-01 | 0.103 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 7.896242e-01 | 0.103 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 7.948116e-01 | 0.100 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 7.992475e-01 | 0.097 | 0 | 0 |
| FRS-mediated FGFR2 signaling | R-HSA-5654700 | 8.056994e-01 | 0.094 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 8.056994e-01 | 0.094 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 8.056994e-01 | 0.094 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 8.056994e-01 | 0.094 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 8.076503e-01 | 0.093 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 8.085413e-01 | 0.092 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 8.085413e-01 | 0.092 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 8.085669e-01 | 0.092 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 8.085669e-01 | 0.092 | 0 | 0 |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | R-HSA-629594 | 8.085669e-01 | 0.092 | 0 | 0 |
| TET1,2,3 and TDG demethylate DNA | R-HSA-5221030 | 8.085669e-01 | 0.092 | 0 | 0 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | R-HSA-5140745 | 8.085669e-01 | 0.092 | 0 | 0 |
| Interleukin-27 signaling | R-HSA-9020956 | 8.085669e-01 | 0.092 | 0 | 0 |
| Formation of intermediate mesoderm | R-HSA-9761174 | 8.085669e-01 | 0.092 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 8.085669e-01 | 0.092 | 0 | 0 |
| Arachidonate production from DAG | R-HSA-426048 | 8.085669e-01 | 0.092 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 8.085669e-01 | 0.092 | 0 | 0 |
| Maturation of spike protein | R-HSA-9683686 | 8.085669e-01 | 0.092 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 8.085669e-01 | 0.092 | 0 | 0 |
| Sperm Motility And Taxes | R-HSA-1300642 | 8.085669e-01 | 0.092 | 0 | 0 |
| Metal sequestration by antimicrobial proteins | R-HSA-6799990 | 8.085669e-01 | 0.092 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 8.085669e-01 | 0.092 | 0 | 0 |
| Serotonin receptors | R-HSA-390666 | 8.085669e-01 | 0.092 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 8.100803e-01 | 0.091 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 8.120289e-01 | 0.090 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 8.143004e-01 | 0.089 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 8.209317e-01 | 0.086 | 0 | 0 |
| Activation of Matrix Metalloproteinases | R-HSA-1592389 | 8.209317e-01 | 0.086 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 8.209317e-01 | 0.086 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 8.260618e-01 | 0.083 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 8.260618e-01 | 0.083 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 8.261285e-01 | 0.083 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 8.261285e-01 | 0.083 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 8.261285e-01 | 0.083 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 8.267049e-01 | 0.083 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 8.314365e-01 | 0.080 | 0 | 0 |
| FGFRL1 modulation of FGFR1 signaling | R-HSA-5658623 | 8.314365e-01 | 0.080 | 0 | 0 |
| Chylomicron assembly | R-HSA-8963888 | 8.314365e-01 | 0.080 | 0 | 0 |
| Synthesis of PIPs at the ER membrane | R-HSA-1483248 | 8.314365e-01 | 0.080 | 0 | 0 |
| Inorganic anion exchange by SLC26 transporters | R-HSA-427601 | 8.314365e-01 | 0.080 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 8.314365e-01 | 0.080 | 0 | 0 |
| Biosynthesis of DPAn-3-derived maresins | R-HSA-9026290 | 8.314365e-01 | 0.080 | 0 | 0 |
| Suppression of apoptosis | R-HSA-9635465 | 8.314365e-01 | 0.080 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 8.314365e-01 | 0.080 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 8.335357e-01 | 0.079 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 8.350501e-01 | 0.078 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 8.351334e-01 | 0.078 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 8.351334e-01 | 0.078 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 8.404357e-01 | 0.075 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 8.422476e-01 | 0.075 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 8.422476e-01 | 0.075 | 0 | 0 |
| FGFR2 ligand binding and activation | R-HSA-190241 | 8.422476e-01 | 0.075 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 8.422476e-01 | 0.075 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 8.422476e-01 | 0.075 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 8.469079e-01 | 0.072 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 8.469079e-01 | 0.072 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 8.469079e-01 | 0.072 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 8.475124e-01 | 0.072 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 8.476943e-01 | 0.072 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 8.483533e-01 | 0.071 | 0 | 0 |
| Endosomal/Vacuolar pathway | R-HSA-1236977 | 8.515751e-01 | 0.070 | 0 | 0 |
| ERKs are inactivated | R-HSA-202670 | 8.515751e-01 | 0.070 | 0 | 0 |
| Viral RNP Complexes in the Host Cell Nucleus | R-HSA-168330 | 8.515751e-01 | 0.070 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 8.515751e-01 | 0.070 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 8.569983e-01 | 0.067 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 8.569983e-01 | 0.067 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 8.569983e-01 | 0.067 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 8.610990e-01 | 0.065 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 8.614721e-01 | 0.065 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 8.650457e-01 | 0.063 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 8.684688e-01 | 0.061 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 8.691389e-01 | 0.061 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 8.693088e-01 | 0.061 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 8.693088e-01 | 0.061 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 8.693088e-01 | 0.061 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 8.693088e-01 | 0.061 | 0 | 0 |
| Interleukin-35 Signalling | R-HSA-8984722 | 8.693088e-01 | 0.061 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 8.693088e-01 | 0.061 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 8.693088e-01 | 0.061 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 8.693088e-01 | 0.061 | 0 | 0 |
| Biosynthesis of DPAn-3-derived protectins and resolvins | R-HSA-9026286 | 8.693088e-01 | 0.061 | 0 | 0 |
| Activated NTRK2 signals through FRS2 and FRS3 | R-HSA-9028731 | 8.693088e-01 | 0.061 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 8.693088e-01 | 0.061 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 8.702368e-01 | 0.060 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 8.704773e-01 | 0.060 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 8.704773e-01 | 0.060 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 8.704773e-01 | 0.060 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 8.704773e-01 | 0.060 | 0 | 0 |
| Neurotoxicity of clostridium toxins | R-HSA-168799 | 8.704773e-01 | 0.060 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 8.704773e-01 | 0.060 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 8.711980e-01 | 0.060 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 8.731260e-01 | 0.059 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 8.774026e-01 | 0.057 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 8.774026e-01 | 0.057 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 8.785340e-01 | 0.056 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 8.785340e-01 | 0.056 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 8.785340e-01 | 0.056 | 0 | 0 |
| Glutamate and glutamine metabolism | R-HSA-8964539 | 8.826150e-01 | 0.054 | 0 | 0 |
| Regulation of PTEN mRNA translation | R-HSA-8943723 | 8.827779e-01 | 0.054 | 0 | 0 |
| Interleukin-20 family signaling | R-HSA-8854691 | 8.827779e-01 | 0.054 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | R-HSA-9029558 | 8.849246e-01 | 0.053 | 0 | 0 |
| IL-6-type cytokine receptor ligand interactions | R-HSA-6788467 | 8.849246e-01 | 0.053 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 8.849246e-01 | 0.053 | 0 | 0 |
| Chylomicron remodeling | R-HSA-8963901 | 8.849246e-01 | 0.053 | 0 | 0 |
| Mtb iron assimilation by chelation | R-HSA-1222449 | 8.849246e-01 | 0.053 | 0 | 0 |
| Reversible hydration of carbon dioxide | R-HSA-1475029 | 8.849246e-01 | 0.053 | 0 | 0 |
| rRNA modification in the mitochondrion | R-HSA-6793080 | 8.849246e-01 | 0.053 | 0 | 0 |
| Acyl chain remodeling of DAG and TAG | R-HSA-1482883 | 8.849246e-01 | 0.053 | 0 | 0 |
| Replication of the SARS-CoV-1 genome | R-HSA-9682706 | 8.849246e-01 | 0.053 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 8.858679e-01 | 0.053 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 8.873639e-01 | 0.052 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 8.923995e-01 | 0.049 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 8.923995e-01 | 0.049 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 8.925104e-01 | 0.049 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 8.933892e-01 | 0.049 | 0 | 0 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 8.939892e-01 | 0.049 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 8.939892e-01 | 0.049 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 8.939892e-01 | 0.049 | 0 | 0 |
| TNFs bind their physiological receptors | R-HSA-5669034 | 8.939892e-01 | 0.049 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 8.949934e-01 | 0.048 | 0 | 0 |
| Retrograde neurotrophin signalling | R-HSA-177504 | 8.986753e-01 | 0.046 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 8.986753e-01 | 0.046 | 0 | 0 |
| Biosynthesis of E-series 18(R)-resolvins | R-HSA-9023661 | 8.986753e-01 | 0.046 | 0 | 0 |
| Prolactin receptor signaling | R-HSA-1170546 | 8.986753e-01 | 0.046 | 0 | 0 |
| Malate-aspartate shuttle | R-HSA-9856872 | 8.986753e-01 | 0.046 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 8.986753e-01 | 0.046 | 0 | 0 |
| Ciprofloxacin ADME | R-HSA-9793528 | 8.986753e-01 | 0.046 | 0 | 0 |
| P2Y receptors | R-HSA-417957 | 8.986753e-01 | 0.046 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 8.986753e-01 | 0.046 | 0 | 0 |
| SARS-CoV-1 Genome Replication and Transcription | R-HSA-9679514 | 8.986753e-01 | 0.046 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 9.012853e-01 | 0.045 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 9.034711e-01 | 0.044 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 9.041958e-01 | 0.044 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 9.041958e-01 | 0.044 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 9.097993e-01 | 0.041 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 9.107836e-01 | 0.041 | 0 | 0 |
| RNA Polymerase III Chain Elongation | R-HSA-73780 | 9.107836e-01 | 0.041 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 9.107836e-01 | 0.041 | 0 | 0 |
| Protein lipoylation | R-HSA-9857492 | 9.107836e-01 | 0.041 | 0 | 0 |
| Signaling by Activin | R-HSA-1502540 | 9.107836e-01 | 0.041 | 0 | 0 |
| Protein repair | R-HSA-5676934 | 9.107836e-01 | 0.041 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 9.107836e-01 | 0.041 | 0 | 0 |
| Dopamine clearance from the synaptic cleft | R-HSA-379401 | 9.107836e-01 | 0.041 | 0 | 0 |
| Other semaphorin interactions | R-HSA-416700 | 9.107836e-01 | 0.041 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.134778e-01 | 0.039 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 9.134778e-01 | 0.039 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 9.134778e-01 | 0.039 | 0 | 0 |
| Abacavir ADME | R-HSA-2161522 | 9.134778e-01 | 0.039 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.135983e-01 | 0.039 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 9.144109e-01 | 0.039 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 9.175049e-01 | 0.037 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 9.181505e-01 | 0.037 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 9.181505e-01 | 0.037 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 9.194461e-01 | 0.036 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.210398e-01 | 0.036 | 0 | 0 |
| Entry of Influenza Virion into Host Cell via Endocytosis | R-HSA-168275 | 9.214456e-01 | 0.036 | 0 | 0 |
| Activation of the phototransduction cascade | R-HSA-2485179 | 9.214456e-01 | 0.036 | 0 | 0 |
| Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | R-HSA-9942503 | 9.214456e-01 | 0.036 | 0 | 0 |
| Differentiation of T cells | R-HSA-9945266 | 9.214456e-01 | 0.036 | 0 | 0 |
| Synthesis of wybutosine at G37 of tRNA(Phe) | R-HSA-6782861 | 9.214456e-01 | 0.036 | 0 | 0 |
| Atorvastatin ADME | R-HSA-9754706 | 9.214456e-01 | 0.036 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 9.219102e-01 | 0.035 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 9.219102e-01 | 0.035 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 9.219102e-01 | 0.035 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 9.245638e-01 | 0.034 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 9.292653e-01 | 0.032 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 9.292662e-01 | 0.032 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 9.300931e-01 | 0.031 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 9.305213e-01 | 0.031 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 9.308339e-01 | 0.031 | 0 | 0 |
| SHC1 events in ERBB4 signaling | R-HSA-1250347 | 9.308339e-01 | 0.031 | 0 | 0 |
| Glycine degradation | R-HSA-6783984 | 9.308339e-01 | 0.031 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 9.308339e-01 | 0.031 | 0 | 0 |
| Scavenging by Class B Receptors | R-HSA-3000471 | 9.308339e-01 | 0.031 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | R-HSA-400511 | 9.308339e-01 | 0.031 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 9.311411e-01 | 0.031 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 9.311411e-01 | 0.031 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 9.311411e-01 | 0.031 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 9.334016e-01 | 0.030 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 9.340660e-01 | 0.030 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 9.353138e-01 | 0.029 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 9.365036e-01 | 0.028 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 9.371515e-01 | 0.028 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 9.371515e-01 | 0.028 | 1 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 9.386605e-01 | 0.027 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 9.391007e-01 | 0.027 | 0 | 0 |
| Biosynthesis of aspirin-triggered D-series resolvins | R-HSA-9020265 | 9.391007e-01 | 0.027 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 9.391007e-01 | 0.027 | 0 | 0 |
| Sulfide oxidation to sulfate | R-HSA-1614517 | 9.391007e-01 | 0.027 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 9.391007e-01 | 0.027 | 0 | 0 |
| GDP-fucose biosynthesis | R-HSA-6787639 | 9.391007e-01 | 0.027 | 0 | 0 |
| Choline catabolism | R-HSA-6798163 | 9.391007e-01 | 0.027 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 9.391007e-01 | 0.027 | 0 | 0 |
| Replication of the SARS-CoV-2 genome | R-HSA-9694686 | 9.391007e-01 | 0.027 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 9.411763e-01 | 0.026 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 9.418328e-01 | 0.026 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 9.426736e-01 | 0.026 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 9.427915e-01 | 0.026 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.427915e-01 | 0.026 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 9.427915e-01 | 0.026 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 9.437710e-01 | 0.025 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 9.455520e-01 | 0.024 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 9.455520e-01 | 0.024 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 9.455520e-01 | 0.024 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 9.459251e-01 | 0.024 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 9.463799e-01 | 0.024 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 9.463799e-01 | 0.024 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 9.463799e-01 | 0.024 | 0 | 0 |
| Biosynthesis of Lipoxins (LX) | R-HSA-2142700 | 9.463799e-01 | 0.024 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 9.463799e-01 | 0.024 | 0 | 0 |
| Nucleotide-like (purinergic) receptors | R-HSA-418038 | 9.463799e-01 | 0.024 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 9.484838e-01 | 0.023 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 9.484838e-01 | 0.023 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 9.484838e-01 | 0.023 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 9.484838e-01 | 0.023 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 9.484838e-01 | 0.023 | 0 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 9.503205e-01 | 0.022 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 9.523914e-01 | 0.021 | 0 | 0 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 9.523914e-01 | 0.021 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 9.527894e-01 | 0.021 | 0 | 0 |
| Pyrimidine biosynthesis | R-HSA-500753 | 9.527894e-01 | 0.021 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 9.527894e-01 | 0.021 | 0 | 0 |
| Synthesis of 5-eicosatetraenoic acids | R-HSA-2142688 | 9.527894e-01 | 0.021 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 9.527894e-01 | 0.021 | 0 | 0 |
| Crosslinking of collagen fibrils | R-HSA-2243919 | 9.527894e-01 | 0.021 | 0 | 0 |
| SARS-CoV-2 Genome Replication and Transcription | R-HSA-9694682 | 9.527894e-01 | 0.021 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.530044e-01 | 0.021 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.530044e-01 | 0.021 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 9.547643e-01 | 0.020 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 9.565251e-01 | 0.019 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 9.566515e-01 | 0.019 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 9.569377e-01 | 0.019 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.577643e-01 | 0.019 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 9.581417e-01 | 0.019 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 9.582542e-01 | 0.019 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 9.582880e-01 | 0.019 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 9.584330e-01 | 0.018 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 9.584330e-01 | 0.018 | 0 | 0 |
| Keratan sulfate degradation | R-HSA-2022857 | 9.584330e-01 | 0.018 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 9.584330e-01 | 0.018 | 0 | 0 |
| Pregnenolone biosynthesis | R-HSA-196108 | 9.584330e-01 | 0.018 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.588339e-01 | 0.018 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 9.605523e-01 | 0.017 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 9.605523e-01 | 0.017 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 9.605523e-01 | 0.017 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 9.613014e-01 | 0.017 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 9.613014e-01 | 0.017 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 9.624929e-01 | 0.017 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 9.624929e-01 | 0.017 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.631488e-01 | 0.016 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 9.634023e-01 | 0.016 | 0 | 0 |
| Biosynthesis of E-series 18(S)-resolvins | R-HSA-9018896 | 9.634023e-01 | 0.016 | 0 | 0 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 9.634023e-01 | 0.016 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 9.634023e-01 | 0.016 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 9.634023e-01 | 0.016 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 9.641214e-01 | 0.016 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.661387e-01 | 0.015 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 9.662889e-01 | 0.015 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 9.662889e-01 | 0.015 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 9.662889e-01 | 0.015 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 9.662889e-01 | 0.015 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 9.662889e-01 | 0.015 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 9.662889e-01 | 0.015 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 9.673846e-01 | 0.014 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 9.673846e-01 | 0.014 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 9.673846e-01 | 0.014 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 9.677778e-01 | 0.014 | 0 | 0 |
| Metabolism of Angiotensinogen to Angiotensins | R-HSA-2022377 | 9.677778e-01 | 0.014 | 0 | 0 |
| Glutathione synthesis and recycling | R-HSA-174403 | 9.677778e-01 | 0.014 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 9.677778e-01 | 0.014 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 9.697136e-01 | 0.013 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 9.697136e-01 | 0.013 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 9.703660e-01 | 0.013 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 9.716303e-01 | 0.012 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 9.716303e-01 | 0.012 | 0 | 0 |
| Biosynthesis of D-series resolvins | R-HSA-9018676 | 9.716303e-01 | 0.012 | 0 | 0 |
| WNT ligand biogenesis and trafficking | R-HSA-3238698 | 9.716303e-01 | 0.012 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 9.716303e-01 | 0.012 | 0 | 0 |
| Cholesterol biosynthesis via lathosterol | R-HSA-6807062 | 9.716303e-01 | 0.012 | 0 | 0 |
| Metabolism of porphyrins | R-HSA-189445 | 9.718125e-01 | 0.012 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 9.728016e-01 | 0.012 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 9.728016e-01 | 0.012 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 9.728016e-01 | 0.012 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 9.737070e-01 | 0.012 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 9.750225e-01 | 0.011 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 9.750225e-01 | 0.011 | 0 | 0 |
| Synthesis of pyrophosphates in the cytosol | R-HSA-1855167 | 9.750225e-01 | 0.011 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 9.750225e-01 | 0.011 | 0 | 0 |
| Biosynthesis of maresins | R-HSA-9018682 | 9.750225e-01 | 0.011 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.752845e-01 | 0.011 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 9.755718e-01 | 0.011 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 9.755844e-01 | 0.011 | 0 | 0 |
| Beta-oxidation of very long chain fatty acids | R-HSA-390247 | 9.755844e-01 | 0.011 | 0 | 0 |
| Lysine catabolism | R-HSA-71064 | 9.755844e-01 | 0.011 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 9.780092e-01 | 0.010 | 0 | 0 |
| Assembly of active LPL and LIPC lipase complexes | R-HSA-8963889 | 9.780092e-01 | 0.010 | 0 | 0 |
| Mitochondrial RNA degradation | R-HSA-9836573 | 9.780092e-01 | 0.010 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.780566e-01 | 0.010 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 9.780907e-01 | 0.010 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 9.780907e-01 | 0.010 | 0 | 0 |
| alpha-linolenic acid (ALA) metabolism | R-HSA-2046106 | 9.780907e-01 | 0.010 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 9.799003e-01 | 0.009 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 9.799455e-01 | 0.009 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 9.800368e-01 | 0.009 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 9.803470e-01 | 0.009 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 9.803470e-01 | 0.009 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 9.803470e-01 | 0.009 | 0 | 0 |
| MicroRNA (miRNA) biogenesis | R-HSA-203927 | 9.806390e-01 | 0.008 | 0 | 0 |
| Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives | R-HSA-9027604 | 9.806390e-01 | 0.008 | 0 | 0 |
| Fertilization | R-HSA-1187000 | 9.806390e-01 | 0.008 | 0 | 0 |
| Beta-oxidation of pristanoyl-CoA | R-HSA-389887 | 9.806390e-01 | 0.008 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.811818e-01 | 0.008 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 9.817799e-01 | 0.008 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 9.823771e-01 | 0.008 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 9.827744e-01 | 0.008 | 0 | 0 |
| Urea cycle | R-HSA-70635 | 9.829544e-01 | 0.007 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 9.829544e-01 | 0.007 | 0 | 0 |
| Synthesis of IP2, IP, and Ins in the cytosol | R-HSA-1855183 | 9.829544e-01 | 0.007 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 9.829544e-01 | 0.007 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 9.842029e-01 | 0.007 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.842029e-01 | 0.007 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 9.842029e-01 | 0.007 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 9.842762e-01 | 0.007 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.842788e-01 | 0.007 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.843090e-01 | 0.007 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.843865e-01 | 0.007 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 9.847172e-01 | 0.007 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 9.849930e-01 | 0.007 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 9.849930e-01 | 0.007 | 0 | 0 |
| Biosynthesis of DPAn-3 SPMs | R-HSA-9025094 | 9.849930e-01 | 0.007 | 0 | 0 |
| Triglyceride biosynthesis | R-HSA-75109 | 9.849930e-01 | 0.007 | 0 | 0 |
| Synthesis of PE | R-HSA-1483213 | 9.849930e-01 | 0.007 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 9.849930e-01 | 0.007 | 0 | 0 |
| Maturation of hRSV A proteins | R-HSA-9828806 | 9.849930e-01 | 0.007 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 9.850471e-01 | 0.007 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 9.856756e-01 | 0.006 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 9.858442e-01 | 0.006 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 9.858442e-01 | 0.006 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 9.858442e-01 | 0.006 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 9.861701e-01 | 0.006 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.861701e-01 | 0.006 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.864622e-01 | 0.006 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 9.867729e-01 | 0.006 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 9.867879e-01 | 0.006 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 9.867879e-01 | 0.006 | 0 | 0 |
| Prednisone ADME | R-HSA-9757110 | 9.867879e-01 | 0.006 | 0 | 0 |
| Pyrimidine salvage | R-HSA-73614 | 9.867879e-01 | 0.006 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.869215e-01 | 0.006 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 9.873190e-01 | 0.006 | 0 | 0 |
| Thyroxine biosynthesis | R-HSA-209968 | 9.883682e-01 | 0.005 | 0 | 0 |
| Biosynthesis of EPA-derived SPMs | R-HSA-9018679 | 9.883682e-01 | 0.005 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 9.886436e-01 | 0.005 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 9.886436e-01 | 0.005 | 0 | 0 |
| Defensins | R-HSA-1461973 | 9.886436e-01 | 0.005 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.891378e-01 | 0.005 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 9.897563e-01 | 0.004 | 0 | 0 |
| Mucopolysaccharidoses | R-HSA-2206281 | 9.897596e-01 | 0.004 | 0 | 0 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | R-HSA-2142691 | 9.898329e-01 | 0.004 | 0 | 0 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | R-HSA-196741 | 9.898329e-01 | 0.004 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.901067e-01 | 0.004 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.904154e-01 | 0.004 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.908686e-01 | 0.004 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.908686e-01 | 0.004 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 9.909002e-01 | 0.004 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 9.909002e-01 | 0.004 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 9.909002e-01 | 0.004 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 9.909002e-01 | 0.004 | 0 | 0 |
| Degradation of cysteine and homocysteine | R-HSA-1614558 | 9.909002e-01 | 0.004 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 9.909389e-01 | 0.004 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.909389e-01 | 0.004 | 0 | 0 |
| Biosynthesis of DPA-derived SPMs | R-HSA-9018683 | 9.909846e-01 | 0.004 | 0 | 0 |
| Synthesis of glycosylphosphatidylinositol (GPI) | R-HSA-162710 | 9.909846e-01 | 0.004 | 0 | 0 |
| Aspartate and asparagine metabolism | R-HSA-8963693 | 9.909846e-01 | 0.004 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 9.912163e-01 | 0.004 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 9.918117e-01 | 0.004 | 0 | 0 |
| Glutathione conjugation | R-HSA-156590 | 9.918117e-01 | 0.004 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 9.920631e-01 | 0.003 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.920631e-01 | 0.003 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.923169e-01 | 0.003 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.927165e-01 | 0.003 | 0 | 0 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | R-HSA-2046104 | 9.927165e-01 | 0.003 | 0 | 0 |
| Defective B3GALTL causes PpS | R-HSA-5083635 | 9.930127e-01 | 0.003 | 0 | 0 |
| Recycling of bile acids and salts | R-HSA-159418 | 9.930127e-01 | 0.003 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 9.932174e-01 | 0.003 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.934864e-01 | 0.003 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 9.934864e-01 | 0.003 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 9.938487e-01 | 0.003 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 9.939695e-01 | 0.003 | 0 | 0 |
| Glyoxylate metabolism and glycine degradation | R-HSA-389661 | 9.941763e-01 | 0.003 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.941763e-01 | 0.003 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 9.945847e-01 | 0.002 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 9.947945e-01 | 0.002 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 9.949089e-01 | 0.002 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 9.952327e-01 | 0.002 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 9.952327e-01 | 0.002 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 9.953482e-01 | 0.002 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 9.958032e-01 | 0.002 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.958032e-01 | 0.002 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.960070e-01 | 0.002 | 0 | 0 |
| Nicotinate metabolism | R-HSA-196807 | 9.960070e-01 | 0.002 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 9.962401e-01 | 0.002 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 9.962876e-01 | 0.002 | 0 | 0 |
| O-glycosylation of TSR domain-containing proteins | R-HSA-5173214 | 9.963055e-01 | 0.002 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 9.963055e-01 | 0.002 | 0 | 0 |
| NCAM1 interactions | R-HSA-419037 | 9.963055e-01 | 0.002 | 0 | 0 |
| SLC-mediated transport of organic cations | R-HSA-549127 | 9.963055e-01 | 0.002 | 0 | 0 |
| Collagen chain trimerization | R-HSA-8948216 | 9.963055e-01 | 0.002 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.970025e-01 | 0.001 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 9.971369e-01 | 0.001 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.974718e-01 | 0.001 | 0 | 0 |
| Maturation of TCA enzymes and regulation of TCA cycle | R-HSA-9854311 | 9.974796e-01 | 0.001 | 0 | 0 |
| rRNA processing in the mitochondrion | R-HSA-8868766 | 9.974796e-01 | 0.001 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.974796e-01 | 0.001 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.976305e-01 | 0.001 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.976418e-01 | 0.001 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.978839e-01 | 0.001 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 9.980469e-01 | 0.001 | 0 | 0 |
| Heme biosynthesis | R-HSA-189451 | 9.980469e-01 | 0.001 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.981227e-01 | 0.001 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 9.982730e-01 | 0.001 | 0 | 0 |
| Signaling by Retinoic Acid | R-HSA-5362517 | 9.983255e-01 | 0.001 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 9.986678e-01 | 0.001 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.987441e-01 | 0.001 | 0 | 0 |
| Complex I biogenesis | R-HSA-6799198 | 9.988130e-01 | 0.001 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 9.988492e-01 | 0.001 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 9.990913e-01 | 0.000 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 9.992325e-01 | 0.000 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 9.992325e-01 | 0.000 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 9.992325e-01 | 0.000 | 0 | 0 |
| Keratan sulfate/keratin metabolism | R-HSA-1638074 | 9.992959e-01 | 0.000 | 0 | 0 |
| Disease | R-HSA-1643685 | 9.993187e-01 | 0.000 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 9.993803e-01 | 0.000 | 0 | 0 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | R-HSA-2162123 | 9.993803e-01 | 0.000 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.994545e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.994886e-01 | 0.000 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.995291e-01 | 0.000 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.995291e-01 | 0.000 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.995362e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.996179e-01 | 0.000 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.996269e-01 | 0.000 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.996911e-01 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 9.997010e-01 | 0.000 | 0 | 0 |
| Citric acid cycle (TCA cycle) | R-HSA-71403 | 9.997045e-01 | 0.000 | 0 | 0 |
| Metabolism of amine-derived hormones | R-HSA-209776 | 9.997118e-01 | 0.000 | 0 | 0 |
| Digestion | R-HSA-8935690 | 9.997118e-01 | 0.000 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.997463e-01 | 0.000 | 0 | 0 |
| Post-translational modification: synthesis of GPI-anchored proteins | R-HSA-163125 | 9.997489e-01 | 0.000 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.998035e-01 | 0.000 | 0 | 0 |
| Sialic acid metabolism | R-HSA-4085001 | 9.998035e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.998150e-01 | 0.000 | 0 | 0 |
| Translation | R-HSA-72766 | 9.998264e-01 | 0.000 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.998270e-01 | 0.000 | 0 | 0 |
| Endogenous sterols | R-HSA-211976 | 9.998478e-01 | 0.000 | 0 | 0 |
| Nucleotide salvage | R-HSA-8956321 | 9.998478e-01 | 0.000 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.998536e-01 | 0.000 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.998660e-01 | 0.000 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.998717e-01 | 0.000 | 0 | 0 |
| Sensory perception of sweet, bitter, and umami (glutamate) taste | R-HSA-9717207 | 9.998724e-01 | 0.000 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.998790e-01 | 0.000 | 0 | 0 |
| Digestion and absorption | R-HSA-8963743 | 9.998821e-01 | 0.000 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.998962e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid biosynthesis | R-HSA-9840309 | 9.998962e-01 | 0.000 | 0 | 0 |
| Xenobiotics | R-HSA-211981 | 9.998962e-01 | 0.000 | 0 | 0 |
| Peroxisomal lipid metabolism | R-HSA-390918 | 9.998971e-01 | 0.000 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 9.999004e-01 | 0.000 | 0 | 0 |
| Latent infection - Other responses of Mtb to phagocytosis | R-HSA-1222499 | 9.999086e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.999265e-01 | 0.000 | 0 | 0 |
| Sulfur amino acid metabolism | R-HSA-1614635 | 9.999278e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | R-HSA-193368 | 9.999292e-01 | 0.000 | 0 | 0 |
| Metabolism of steroid hormones | R-HSA-196071 | 9.999292e-01 | 0.000 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 9.999324e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation of mucins | R-HSA-913709 | 9.999377e-01 | 0.000 | 0 | 0 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | R-HSA-420499 | 9.999430e-01 | 0.000 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.999518e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid catabolism | R-HSA-9840310 | 9.999518e-01 | 0.000 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.999530e-01 | 0.000 | 0 | 0 |
| Sensory perception of taste | R-HSA-9717189 | 9.999538e-01 | 0.000 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.999571e-01 | 0.000 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.999575e-01 | 0.000 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.999662e-01 | 0.000 | 0 | 0 |
| Aspirin ADME | R-HSA-9749641 | 9.999671e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.999760e-01 | 0.000 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.999825e-01 | 0.000 | 1 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.999826e-01 | 0.000 | 0 | 0 |
| Metabolic disorders of biological oxidation enzymes | R-HSA-5579029 | 9.999847e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.999863e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.999878e-01 | 0.000 | 0 | 0 |
| Biosynthesis of DHA-derived SPMs | R-HSA-9018677 | 9.999882e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.999917e-01 | 0.000 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.999925e-01 | 0.000 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 9.999952e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.999967e-01 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 9.999973e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999976e-01 | 0.000 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.999980e-01 | 0.000 | 0 | 0 |
| Mitochondrial Fatty Acid Beta-Oxidation | R-HSA-77289 | 9.999985e-01 | 0.000 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.999988e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid metabolism | R-HSA-1660662 | 9.999995e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.999996e-01 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 9.999999e-01 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 9.999999e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999999e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.999999e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 9.999999e-01 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 1.000000e+00 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 1.000000e+00 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 1.000000e+00 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 1.000000e+00 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 1.000000e+00 | 0.000 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of specialized proresolving mediators (SPMs) | R-HSA-9018678 | 1.000000e+00 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 1.000000e+00 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 1.000000e+00 | 0.000 | 0 | 0 |
| Cytochrome P450 - arranged by substrate type | R-HSA-211897 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 1 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Eukaryotic Translation Elongation | R-HSA-156842 | 1.110223e-16 | 15.955 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 1.110223e-16 | 15.955 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 1.110223e-16 | 15.955 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 1.110223e-16 | 15.955 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 1.110223e-16 | 15.955 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 1.110223e-16 | 15.955 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 1.110223e-16 | 15.955 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 1.110223e-16 | 15.955 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 1.110223e-16 | 15.955 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 1.110223e-16 | 15.955 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 1.110223e-16 | 15.955 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 1.110223e-16 | 15.955 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 1.110223e-16 | 15.955 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 1.110223e-16 | 15.955 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 1.110223e-16 | 15.955 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 3.330669e-16 | 15.477 | 0 | 0 |
| M Phase | R-HSA-68886 | 3.330669e-16 | 15.477 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 5.551115e-16 | 15.256 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 7.771561e-16 | 15.109 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 8.881784e-16 | 15.051 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 1.110223e-15 | 14.955 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 3.219647e-15 | 14.492 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 4.551914e-15 | 14.342 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 4.551914e-15 | 14.342 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 9.325873e-15 | 14.030 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 1.076916e-14 | 13.968 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 1.076916e-14 | 13.968 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 1.165734e-14 | 13.933 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 1.165734e-14 | 13.933 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 2.187139e-14 | 13.660 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 3.230749e-14 | 13.491 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 4.007905e-14 | 13.397 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 7.138734e-14 | 13.146 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 1.151301e-13 | 12.939 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 1.310063e-13 | 12.883 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 1.825207e-13 | 12.739 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 2.094991e-13 | 12.679 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 2.081668e-13 | 12.682 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 2.325917e-13 | 12.633 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 2.866596e-13 | 12.543 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 2.989831e-13 | 12.524 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 3.144152e-13 | 12.502 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 4.781731e-13 | 12.320 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 6.765699e-13 | 12.170 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 9.051648e-13 | 12.043 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 1.861733e-12 | 11.730 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 3.770095e-12 | 11.424 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 5.186740e-12 | 11.285 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 5.213163e-12 | 11.283 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 6.965872e-12 | 11.157 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 7.264300e-12 | 11.139 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 8.188672e-12 | 11.087 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 8.121503e-12 | 11.090 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 9.988121e-12 | 11.001 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 1.649525e-11 | 10.783 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 1.624290e-11 | 10.789 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 3.017064e-11 | 10.520 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 3.068445e-11 | 10.513 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 3.742273e-11 | 10.427 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 4.280631e-11 | 10.368 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 4.958289e-11 | 10.305 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 8.271550e-11 | 10.082 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 8.481371e-11 | 10.072 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 8.556134e-11 | 10.068 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 9.783985e-11 | 10.009 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 9.935930e-11 | 10.003 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 1.072271e-10 | 9.970 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 1.312852e-10 | 9.882 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 1.318118e-10 | 9.880 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 1.592561e-10 | 9.798 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 1.770958e-10 | 9.752 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 1.776135e-10 | 9.751 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 2.111910e-10 | 9.675 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 2.259204e-10 | 9.646 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 2.422765e-10 | 9.616 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 2.630030e-10 | 9.580 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 3.328455e-10 | 9.478 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 3.519852e-10 | 9.453 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 4.340007e-10 | 9.363 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 4.329642e-10 | 9.364 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 4.281411e-10 | 9.368 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 4.281411e-10 | 9.368 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 6.732377e-10 | 9.172 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 8.381955e-10 | 9.077 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 1.003278e-09 | 8.999 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 1.283564e-09 | 8.892 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 1.632174e-09 | 8.787 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 1.657368e-09 | 8.781 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 1.895341e-09 | 8.722 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 1.962534e-09 | 8.707 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 1.981618e-09 | 8.703 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 2.080285e-09 | 8.682 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 2.083557e-09 | 8.681 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 2.573518e-09 | 8.589 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 2.612555e-09 | 8.583 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 2.657958e-09 | 8.575 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 2.657958e-09 | 8.575 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 3.577832e-09 | 8.446 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 3.655435e-09 | 8.437 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 3.573020e-09 | 8.447 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 3.720608e-09 | 8.429 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 4.100989e-09 | 8.387 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 4.302132e-09 | 8.366 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 4.338252e-09 | 8.363 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 4.556897e-09 | 8.341 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 4.697448e-09 | 8.328 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 4.791318e-09 | 8.320 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 6.373059e-09 | 8.196 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 7.341940e-09 | 8.134 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 8.261592e-09 | 8.083 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 9.216448e-09 | 8.035 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 9.907764e-09 | 8.004 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 1.043206e-08 | 7.982 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 1.154668e-08 | 7.938 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 1.154668e-08 | 7.938 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 1.218244e-08 | 7.914 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 1.220909e-08 | 7.913 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 1.338443e-08 | 7.873 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 1.395536e-08 | 7.855 | 0 | 0 |
| Translation | R-HSA-72766 | 1.412984e-08 | 7.850 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 1.571313e-08 | 7.804 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 1.766863e-08 | 7.753 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 1.651863e-08 | 7.782 | 0 | 0 |
| Kinesins | R-HSA-983189 | 1.656117e-08 | 7.781 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 1.766863e-08 | 7.753 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 2.265258e-08 | 7.645 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 2.295736e-08 | 7.639 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 2.338242e-08 | 7.631 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 2.477623e-08 | 7.606 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 2.544217e-08 | 7.594 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 3.058719e-08 | 7.514 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 3.210624e-08 | 7.493 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 3.323311e-08 | 7.478 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 3.323311e-08 | 7.478 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 3.913540e-08 | 7.407 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 3.913540e-08 | 7.407 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 4.166926e-08 | 7.380 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 4.627025e-08 | 7.335 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 4.867641e-08 | 7.313 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 5.073686e-08 | 7.295 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 5.972720e-08 | 7.224 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 5.972720e-08 | 7.224 | 0 | 0 |
| Depurination | R-HSA-73927 | 6.946446e-08 | 7.158 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 9.480214e-08 | 7.023 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 9.900387e-08 | 7.004 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 1.100840e-07 | 6.958 | 0 | 0 |
| Protein folding | R-HSA-391251 | 1.230880e-07 | 6.910 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 1.283835e-07 | 6.891 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 1.367818e-07 | 6.864 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 1.581533e-07 | 6.801 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 1.644314e-07 | 6.784 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 1.730408e-07 | 6.762 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 1.731598e-07 | 6.762 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 1.870615e-07 | 6.728 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 1.936070e-07 | 6.713 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 2.281569e-07 | 6.642 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 2.621385e-07 | 6.581 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 2.828748e-07 | 6.548 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 2.895423e-07 | 6.538 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 3.035833e-07 | 6.518 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 3.375599e-07 | 6.472 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 3.488346e-07 | 6.457 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 3.575287e-07 | 6.447 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 3.575287e-07 | 6.447 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 4.072679e-07 | 6.390 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 4.368319e-07 | 6.360 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 5.150716e-07 | 6.288 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 5.963986e-07 | 6.224 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 6.589601e-07 | 6.181 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 6.596739e-07 | 6.181 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 6.773944e-07 | 6.169 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 6.973147e-07 | 6.157 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 8.037108e-07 | 6.095 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 8.037108e-07 | 6.095 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 8.402575e-07 | 6.076 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 8.408832e-07 | 6.075 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 8.517459e-07 | 6.070 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 8.982409e-07 | 6.047 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 9.550105e-07 | 6.020 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 9.674466e-07 | 6.014 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 1.309187e-06 | 5.883 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 1.955507e-06 | 5.709 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 2.283019e-06 | 5.641 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 2.415833e-06 | 5.617 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 2.501014e-06 | 5.602 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 2.907084e-06 | 5.537 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 3.330136e-06 | 5.478 | 0 | 0 |
| Immune System | R-HSA-168256 | 3.652417e-06 | 5.437 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 3.848747e-06 | 5.415 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 5.067303e-06 | 5.295 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 5.026907e-06 | 5.299 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 5.597178e-06 | 5.252 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 5.748256e-06 | 5.240 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 6.173824e-06 | 5.209 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 7.270399e-06 | 5.138 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 8.595639e-06 | 5.066 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 9.953475e-06 | 5.002 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 1.097607e-05 | 4.960 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 1.114473e-05 | 4.953 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 1.242434e-05 | 4.906 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 1.319581e-05 | 4.880 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 1.356725e-05 | 4.868 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 1.493410e-05 | 4.826 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 1.551456e-05 | 4.809 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 1.551456e-05 | 4.809 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 1.551456e-05 | 4.809 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 1.551456e-05 | 4.809 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 1.608958e-05 | 4.793 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 1.615975e-05 | 4.792 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 1.826900e-05 | 4.738 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 1.916200e-05 | 4.718 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 1.929543e-05 | 4.715 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 2.007011e-05 | 4.697 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 2.081514e-05 | 4.682 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 2.121226e-05 | 4.673 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 2.465008e-05 | 4.608 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 2.485163e-05 | 4.605 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 2.740380e-05 | 4.562 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 3.062585e-05 | 4.514 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 3.115797e-05 | 4.506 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 3.158329e-05 | 4.501 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 3.347008e-05 | 4.475 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 3.469164e-05 | 4.460 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 3.676920e-05 | 4.435 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 4.157020e-05 | 4.381 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 4.186798e-05 | 4.378 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 4.590845e-05 | 4.338 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 4.658400e-05 | 4.332 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 4.857911e-05 | 4.314 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 4.865203e-05 | 4.313 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 5.443306e-05 | 4.264 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.626830e-05 | 4.250 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 5.432340e-05 | 4.265 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 5.701674e-05 | 4.244 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 5.798874e-05 | 4.237 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 6.399326e-05 | 4.194 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 6.645448e-05 | 4.177 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 6.920579e-05 | 4.160 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 6.983114e-05 | 4.156 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 7.781142e-05 | 4.109 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 8.085019e-05 | 4.092 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 8.193829e-05 | 4.087 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 9.726846e-05 | 4.012 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 1.079959e-04 | 3.967 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 1.225314e-04 | 3.912 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 1.235904e-04 | 3.908 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 1.289837e-04 | 3.889 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 1.382567e-04 | 3.859 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 1.417599e-04 | 3.848 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 1.492496e-04 | 3.826 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 1.752454e-04 | 3.756 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 1.820166e-04 | 3.740 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 1.926780e-04 | 3.715 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 1.926780e-04 | 3.715 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 2.199572e-04 | 3.658 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 2.242169e-04 | 3.649 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 2.247234e-04 | 3.648 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 2.357273e-04 | 3.628 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 2.357273e-04 | 3.628 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 2.874879e-04 | 3.541 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 2.845786e-04 | 3.546 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 2.845786e-04 | 3.546 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 3.033807e-04 | 3.518 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 3.071622e-04 | 3.513 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 3.197784e-04 | 3.495 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 3.250436e-04 | 3.488 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 3.358206e-04 | 3.474 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 4.005462e-04 | 3.397 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 4.010157e-04 | 3.397 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 4.094055e-04 | 3.388 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 4.121070e-04 | 3.385 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 4.160486e-04 | 3.381 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 4.160486e-04 | 3.381 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 4.186908e-04 | 3.378 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 4.268865e-04 | 3.370 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 4.435913e-04 | 3.353 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 4.435913e-04 | 3.353 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 4.476469e-04 | 3.349 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 4.883503e-04 | 3.311 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 5.300630e-04 | 3.276 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 6.146273e-04 | 3.211 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 6.229360e-04 | 3.206 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 6.356314e-04 | 3.197 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 6.356314e-04 | 3.197 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 6.413806e-04 | 3.193 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 6.413806e-04 | 3.193 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 7.930750e-04 | 3.101 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 7.930750e-04 | 3.101 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 7.930750e-04 | 3.101 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 7.930750e-04 | 3.101 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 7.930750e-04 | 3.101 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 7.930750e-04 | 3.101 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 7.930750e-04 | 3.101 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 7.930750e-04 | 3.101 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 7.930750e-04 | 3.101 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 7.930750e-04 | 3.101 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 7.930750e-04 | 3.101 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 6.616672e-04 | 3.179 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 7.823325e-04 | 3.107 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 6.838604e-04 | 3.165 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 6.838604e-04 | 3.165 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 6.616672e-04 | 3.179 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 8.052643e-04 | 3.094 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 8.193074e-04 | 3.087 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 8.193074e-04 | 3.087 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 8.193074e-04 | 3.087 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 8.367265e-04 | 3.077 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 8.577208e-04 | 3.067 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 9.006838e-04 | 3.045 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 9.285780e-04 | 3.032 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 9.334284e-04 | 3.030 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 9.541158e-04 | 3.020 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 9.948514e-04 | 3.002 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 1.034057e-03 | 2.985 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 1.057153e-03 | 2.976 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 1.168170e-03 | 2.932 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 1.168170e-03 | 2.932 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 1.176063e-03 | 2.930 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 1.224382e-03 | 2.912 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 1.318179e-03 | 2.880 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 1.362695e-03 | 2.866 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 1.456967e-03 | 2.837 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 1.476907e-03 | 2.831 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 1.476907e-03 | 2.831 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 1.533726e-03 | 2.814 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 1.537339e-03 | 2.813 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 1.537339e-03 | 2.813 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 1.541620e-03 | 2.812 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 1.545048e-03 | 2.811 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 1.607245e-03 | 2.794 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 1.629902e-03 | 2.788 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 1.629902e-03 | 2.788 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 1.629902e-03 | 2.788 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 1.640350e-03 | 2.785 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 1.686953e-03 | 2.773 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 1.824055e-03 | 2.739 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 1.931012e-03 | 2.714 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 1.978051e-03 | 2.704 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 2.291485e-03 | 2.640 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 2.271544e-03 | 2.644 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 2.434224e-03 | 2.614 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 2.613753e-03 | 2.583 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 2.645391e-03 | 2.578 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 2.645391e-03 | 2.578 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 2.645391e-03 | 2.578 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 2.504737e-03 | 2.601 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 2.279716e-03 | 2.642 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 2.628224e-03 | 2.580 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 2.294219e-03 | 2.639 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 2.667418e-03 | 2.574 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 2.670651e-03 | 2.573 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 2.869390e-03 | 2.542 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 2.942542e-03 | 2.531 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 2.942542e-03 | 2.531 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 2.969591e-03 | 2.527 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 3.261103e-03 | 2.487 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 3.287550e-03 | 2.483 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 3.355426e-03 | 2.474 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 3.412586e-03 | 2.467 | 0 | 0 |
| MTF1 activates gene expression | R-HSA-5660489 | 3.428510e-03 | 2.465 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 3.429910e-03 | 2.465 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 3.443274e-03 | 2.463 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 3.443274e-03 | 2.463 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 3.515478e-03 | 2.454 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 3.515478e-03 | 2.454 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 3.532956e-03 | 2.452 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 3.547033e-03 | 2.450 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 3.547033e-03 | 2.450 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 3.547033e-03 | 2.450 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 3.547033e-03 | 2.450 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 3.579540e-03 | 2.446 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 3.748195e-03 | 2.426 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 3.862668e-03 | 2.413 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 3.928425e-03 | 2.406 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 3.928425e-03 | 2.406 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 3.980916e-03 | 2.400 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 3.982882e-03 | 2.400 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 4.040722e-03 | 2.394 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 4.040722e-03 | 2.394 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 4.162991e-03 | 2.381 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 4.214556e-03 | 2.375 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 4.342465e-03 | 2.362 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 4.437953e-03 | 2.353 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 4.574890e-03 | 2.340 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperone genes | R-HSA-381183 | 4.574890e-03 | 2.340 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 4.619936e-03 | 2.335 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 4.665266e-03 | 2.331 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 4.836595e-03 | 2.315 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 4.996868e-03 | 2.301 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 5.237571e-03 | 2.281 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 5.237571e-03 | 2.281 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 5.237571e-03 | 2.281 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 5.256841e-03 | 2.279 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 5.345884e-03 | 2.272 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 5.363275e-03 | 2.271 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 5.507286e-03 | 2.259 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 5.564711e-03 | 2.255 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 5.564711e-03 | 2.255 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 5.564711e-03 | 2.255 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 5.564711e-03 | 2.255 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 5.653211e-03 | 2.248 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 5.697617e-03 | 2.244 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 5.889811e-03 | 2.230 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 5.899896e-03 | 2.229 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 6.030425e-03 | 2.220 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 6.199620e-03 | 2.208 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 6.199620e-03 | 2.208 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 6.492269e-03 | 2.188 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 6.559260e-03 | 2.183 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 6.717494e-03 | 2.173 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 6.823557e-03 | 2.166 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 6.823557e-03 | 2.166 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 6.841341e-03 | 2.165 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 6.856587e-03 | 2.164 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 6.856587e-03 | 2.164 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 7.122631e-03 | 2.147 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 8.712750e-03 | 2.060 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 9.155764e-03 | 2.038 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 9.155764e-03 | 2.038 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 8.415679e-03 | 2.075 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 8.415679e-03 | 2.075 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 8.712750e-03 | 2.060 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 7.301094e-03 | 2.137 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 9.114650e-03 | 2.040 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 7.927656e-03 | 2.101 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 7.576162e-03 | 2.121 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 7.927656e-03 | 2.101 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 7.122631e-03 | 2.147 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 8.377096e-03 | 2.077 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 7.661913e-03 | 2.116 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 7.823043e-03 | 2.107 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 8.508463e-03 | 2.070 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 8.712750e-03 | 2.060 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 8.712750e-03 | 2.060 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 8.048971e-03 | 2.094 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 6.991734e-03 | 2.155 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 8.179026e-03 | 2.087 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperones | R-HSA-381033 | 8.207959e-03 | 2.086 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 8.405451e-03 | 2.075 | 0 | 0 |
| Disease | R-HSA-1643685 | 8.472296e-03 | 2.072 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 8.048971e-03 | 2.094 | 0 | 0 |
| Maturation of protein E | R-HSA-9683683 | 9.263965e-03 | 2.033 | 0 | 0 |
| Maturation of protein E | R-HSA-9694493 | 9.263965e-03 | 2.033 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 9.336563e-03 | 2.030 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 9.336563e-03 | 2.030 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 9.538969e-03 | 2.020 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 9.538969e-03 | 2.020 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 9.625312e-03 | 2.017 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 9.625312e-03 | 2.017 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 9.858601e-03 | 2.006 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 9.858601e-03 | 2.006 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 9.858601e-03 | 2.006 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 9.858601e-03 | 2.006 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 1.064532e-02 | 1.973 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 1.064532e-02 | 1.973 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 1.077742e-02 | 1.967 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 1.077742e-02 | 1.967 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 1.077742e-02 | 1.967 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 1.081280e-02 | 1.966 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 1.090985e-02 | 1.962 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 1.090985e-02 | 1.962 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 1.149568e-02 | 1.939 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 1.149568e-02 | 1.939 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 1.176369e-02 | 1.929 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 1.191685e-02 | 1.924 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 1.191685e-02 | 1.924 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 1.225873e-02 | 1.912 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 1.238265e-02 | 1.907 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 1.238452e-02 | 1.907 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 1.293152e-02 | 1.888 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 1.329392e-02 | 1.876 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 1.333036e-02 | 1.875 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 1.355548e-02 | 1.868 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 1.355548e-02 | 1.868 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 1.355548e-02 | 1.868 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 1.355548e-02 | 1.868 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 1.355548e-02 | 1.868 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 1.355548e-02 | 1.868 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 1.355548e-02 | 1.868 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 1.372689e-02 | 1.862 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 1.413118e-02 | 1.850 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 1.413118e-02 | 1.850 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 1.416341e-02 | 1.849 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 1.430171e-02 | 1.845 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 1.457808e-02 | 1.836 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 1.457845e-02 | 1.836 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 1.462303e-02 | 1.835 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 1.462303e-02 | 1.835 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 1.462303e-02 | 1.835 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 1.463828e-02 | 1.835 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 1.463828e-02 | 1.835 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 1.463828e-02 | 1.835 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 1.468439e-02 | 1.833 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 1.482807e-02 | 1.829 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 1.482807e-02 | 1.829 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 1.482807e-02 | 1.829 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 1.483780e-02 | 1.829 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 1.483780e-02 | 1.829 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 1.537625e-02 | 1.813 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 1.537625e-02 | 1.813 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 1.537625e-02 | 1.813 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 1.537625e-02 | 1.813 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 1.584245e-02 | 1.800 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 1.613084e-02 | 1.792 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 1.622536e-02 | 1.790 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 1.622536e-02 | 1.790 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 1.651081e-02 | 1.782 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 1.660825e-02 | 1.780 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 1.697974e-02 | 1.770 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 1.697974e-02 | 1.770 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 1.743266e-02 | 1.759 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 1.763790e-02 | 1.754 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 1.763790e-02 | 1.754 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 1.763790e-02 | 1.754 | 0 | 0 |
| Loss of MECP2 binding ability to 5hmC-DNA | R-HSA-9022534 | 1.773312e-02 | 1.751 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 1.829600e-02 | 1.738 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 1.845094e-02 | 1.734 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 1.855836e-02 | 1.731 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 1.899346e-02 | 1.721 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 1.899346e-02 | 1.721 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 1.910243e-02 | 1.719 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 2.623660e-02 | 1.581 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 2.095631e-02 | 1.679 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 2.551963e-02 | 1.593 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 2.551963e-02 | 1.593 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 2.373460e-02 | 1.625 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 2.749682e-02 | 1.561 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 2.201443e-02 | 1.657 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 2.523149e-02 | 1.598 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 2.326279e-02 | 1.633 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 2.079012e-02 | 1.682 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 2.608545e-02 | 1.584 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 2.025294e-02 | 1.694 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 2.593736e-02 | 1.586 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 2.062440e-02 | 1.686 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 1.996951e-02 | 1.700 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 2.326279e-02 | 1.633 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 2.551963e-02 | 1.593 | 0 | 0 |
| FLT3 signaling through SRC family kinases | R-HSA-9706374 | 2.348503e-02 | 1.629 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 2.584205e-02 | 1.588 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 2.095631e-02 | 1.679 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 2.420659e-02 | 1.616 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 2.749682e-02 | 1.561 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 2.323296e-02 | 1.634 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 2.571835e-02 | 1.590 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 2.571835e-02 | 1.590 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 2.867958e-02 | 1.542 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 1.921788e-02 | 1.716 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 2.506093e-02 | 1.601 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 2.373460e-02 | 1.625 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 2.749682e-02 | 1.561 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 2.295672e-02 | 1.639 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 2.041230e-02 | 1.690 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 2.112368e-02 | 1.675 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 2.011025e-02 | 1.697 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 2.321508e-02 | 1.634 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 2.420659e-02 | 1.616 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 2.420659e-02 | 1.616 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 2.066976e-02 | 1.685 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 2.532597e-02 | 1.596 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 2.722969e-02 | 1.565 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 2.430101e-02 | 1.614 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 1.928340e-02 | 1.715 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 2.506093e-02 | 1.601 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 2.112368e-02 | 1.675 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 2.366313e-02 | 1.626 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 2.389011e-02 | 1.622 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 2.867958e-02 | 1.542 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 2.101451e-02 | 1.677 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 2.066976e-02 | 1.685 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 2.015536e-02 | 1.696 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 2.117620e-02 | 1.674 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 2.420659e-02 | 1.616 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 2.593736e-02 | 1.586 | 0 | 0 |
| Modulation by Mtb of host immune system | R-HSA-9637628 | 2.623660e-02 | 1.581 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 2.876824e-02 | 1.541 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 2.914775e-02 | 1.535 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 2.923523e-02 | 1.534 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 2.923523e-02 | 1.534 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 2.923523e-02 | 1.534 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 2.923523e-02 | 1.534 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 2.947298e-02 | 1.531 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 2.991081e-02 | 1.524 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 3.026044e-02 | 1.519 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 3.026044e-02 | 1.519 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 3.069993e-02 | 1.513 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 3.069993e-02 | 1.513 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 3.069993e-02 | 1.513 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 3.069993e-02 | 1.513 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 3.101168e-02 | 1.508 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 3.153223e-02 | 1.501 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 3.153223e-02 | 1.501 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 3.165304e-02 | 1.500 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 3.173592e-02 | 1.498 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 3.173592e-02 | 1.498 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 3.173592e-02 | 1.498 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 3.173592e-02 | 1.498 | 0 | 0 |
| NFE2L2 regulating MDR associated enzymes | R-HSA-9818032 | 3.440614e-02 | 1.463 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 3.440614e-02 | 1.463 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 3.467536e-02 | 1.460 | 0 | 0 |
| Co-inhibition by BTLA | R-HSA-9927353 | 3.467536e-02 | 1.460 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 3.467536e-02 | 1.460 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 3.621905e-02 | 1.441 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 3.632179e-02 | 1.440 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 3.652281e-02 | 1.437 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 3.652281e-02 | 1.437 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 3.670111e-02 | 1.435 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 3.718800e-02 | 1.430 | 0 | 0 |
| Manipulation of host energy metabolism | R-HSA-9636667 | 3.736585e-02 | 1.428 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 3.736585e-02 | 1.428 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 3.865718e-02 | 1.413 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 3.890787e-02 | 1.410 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 3.986538e-02 | 1.399 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 4.088952e-02 | 1.388 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 4.300896e-02 | 1.366 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 4.343065e-02 | 1.362 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 4.389341e-02 | 1.358 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 4.389341e-02 | 1.358 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 4.412517e-02 | 1.355 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 4.501245e-02 | 1.347 | 0 | 0 |
| Translesion synthesis by REV1 | R-HSA-110312 | 4.501245e-02 | 1.347 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 4.501245e-02 | 1.347 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 4.539376e-02 | 1.343 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 4.546843e-02 | 1.342 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 4.575263e-02 | 1.340 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 4.575263e-02 | 1.340 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 4.663499e-02 | 1.331 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 4.663499e-02 | 1.331 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 4.663499e-02 | 1.331 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 4.703382e-02 | 1.328 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 4.801159e-02 | 1.319 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 4.814694e-02 | 1.317 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 4.814694e-02 | 1.317 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 4.814694e-02 | 1.317 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 4.836932e-02 | 1.315 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 5.017396e-02 | 1.300 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 12 | R-HSA-392170 | 5.017396e-02 | 1.300 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 5.056055e-02 | 1.296 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 5.056055e-02 | 1.296 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 5.056055e-02 | 1.296 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 5.168969e-02 | 1.287 | 1 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 5.224440e-02 | 1.282 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 5.224440e-02 | 1.282 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 5.374714e-02 | 1.270 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 5.374714e-02 | 1.270 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 5.430193e-02 | 1.265 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 5.647990e-02 | 1.248 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 5.647990e-02 | 1.248 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 5.730186e-02 | 1.242 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 5.739322e-02 | 1.241 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 5.788841e-02 | 1.237 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 5.802820e-02 | 1.236 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 5.802820e-02 | 1.236 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 5.802820e-02 | 1.236 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 5.802820e-02 | 1.236 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 5.883460e-02 | 1.230 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 5.883460e-02 | 1.230 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 5.883460e-02 | 1.230 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 5.928651e-02 | 1.227 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 5.952743e-02 | 1.225 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 5.997865e-02 | 1.222 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 6.087648e-02 | 1.216 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 6.210923e-02 | 1.207 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 6.224603e-02 | 1.206 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 6.339585e-02 | 1.198 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 6.339585e-02 | 1.198 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 6.339585e-02 | 1.198 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 6.379451e-02 | 1.195 | 0 | 0 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 6.379451e-02 | 1.195 | 0 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 6.379451e-02 | 1.195 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 6.590428e-02 | 1.181 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 6.594345e-02 | 1.181 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 6.657683e-02 | 1.177 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 6.657683e-02 | 1.177 | 0 | 0 |
| Reduction of cytosolic Ca++ levels | R-HSA-418359 | 6.681163e-02 | 1.175 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 6.681163e-02 | 1.175 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 6.688484e-02 | 1.175 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 6.997694e-02 | 1.155 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 7.078216e-02 | 1.150 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 7.287530e-02 | 1.137 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 7.395316e-02 | 1.131 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 7.395316e-02 | 1.131 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 7.395316e-02 | 1.131 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 7.395316e-02 | 1.131 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 7.395316e-02 | 1.131 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 7.476044e-02 | 1.126 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 7.504207e-02 | 1.125 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 7.618579e-02 | 1.118 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 7.618579e-02 | 1.118 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 7.631210e-02 | 1.117 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 7.686483e-02 | 1.114 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 8.018953e-02 | 1.096 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 8.018953e-02 | 1.096 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 8.018953e-02 | 1.096 | 0 | 0 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 8.018953e-02 | 1.096 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 8.018953e-02 | 1.096 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 8.103806e-02 | 1.091 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 8.105005e-02 | 1.091 | 0 | 0 |
| NOSTRIN mediated eNOS trafficking | R-HSA-203641 | 8.147054e-02 | 1.089 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 8.147054e-02 | 1.089 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 8.147054e-02 | 1.089 | 0 | 0 |
| S Phase | R-HSA-69242 | 8.218680e-02 | 1.085 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 8.218680e-02 | 1.085 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 8.375765e-02 | 1.077 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 8.375765e-02 | 1.077 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 8.415262e-02 | 1.075 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 8.415262e-02 | 1.075 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 8.540502e-02 | 1.069 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 8.540502e-02 | 1.069 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 8.540502e-02 | 1.069 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 8.554399e-02 | 1.068 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 8.575238e-02 | 1.067 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 8.575238e-02 | 1.067 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 8.575238e-02 | 1.067 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 8.630791e-02 | 1.064 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 8.631004e-02 | 1.064 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 8.722534e-02 | 1.059 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 8.786226e-02 | 1.056 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 8.878023e-02 | 1.052 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 8.878023e-02 | 1.052 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 9.576645e-02 | 1.019 | 0 | 0 |
| Activation, translocation and oligomerization of BAX | R-HSA-114294 | 1.823668e-01 | 0.739 | 0 | 0 |
| Regulation of PAK-2p34 activity by PS-GAP/RHG10 | R-HSA-211728 | 1.823668e-01 | 0.739 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 1.823668e-01 | 0.739 | 0 | 0 |
| Drug-mediated inhibition of MET activation | R-HSA-9734091 | 1.823668e-01 | 0.739 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 1.823668e-01 | 0.739 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 1.823668e-01 | 0.739 | 0 | 0 |
| TICAM1 deficiency - HSE | R-HSA-5602566 | 1.823668e-01 | 0.739 | 0 | 0 |
| RPIA deficiency: failed conversion of RU5P to R5P | R-HSA-6791461 | 1.823668e-01 | 0.739 | 0 | 0 |
| SARS-CoV-1 targets PDZ proteins in cell-cell junction | R-HSA-9692912 | 1.823668e-01 | 0.739 | 0 | 0 |
| Defective Mismatch Repair Associated With MLH1 | R-HSA-5545483 | 1.823668e-01 | 0.739 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH3 | R-HSA-5632927 | 1.823668e-01 | 0.739 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH6 | R-HSA-5632968 | 1.823668e-01 | 0.739 | 0 | 0 |
| Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) | R-HSA-5619043 | 1.823668e-01 | 0.739 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 1.823668e-01 | 0.739 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | R-HSA-9645722 | 1.823668e-01 | 0.739 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 1.823668e-01 | 0.739 | 0 | 0 |
| RPIA deficiency: failed conversion of R5P to RU5P | R-HSA-5659996 | 1.823668e-01 | 0.739 | 0 | 0 |
| Hereditary fructose intolerance | R-HSA-5657560 | 1.823668e-01 | 0.739 | 0 | 0 |
| Defective Mismatch Repair Associated With PMS2 | R-HSA-5632987 | 1.823668e-01 | 0.739 | 0 | 0 |
| STAT6-mediated induction of chemokines | R-HSA-3249367 | 9.118976e-02 | 1.040 | 0 | 0 |
| Diseases of Mismatch Repair (MMR) | R-HSA-5423599 | 9.118976e-02 | 1.040 | 0 | 0 |
| Loss of MECP2 binding ability to 5mC-DNA | R-HSA-9022538 | 9.118976e-02 | 1.040 | 0 | 0 |
| MECP2 regulates transcription of genes involved in GABA signaling | R-HSA-9022927 | 1.231916e-01 | 0.909 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 1.231916e-01 | 0.909 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 1.231916e-01 | 0.909 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 1.231916e-01 | 0.909 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 1.231916e-01 | 0.909 | 0 | 0 |
| NFE2L2 regulating inflammation associated genes | R-HSA-9818026 | 1.574011e-01 | 0.803 | 0 | 0 |
| IRS activation | R-HSA-74713 | 1.574011e-01 | 0.803 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 1.574011e-01 | 0.803 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 1.574011e-01 | 0.803 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 1.009983e-01 | 0.996 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 1.009983e-01 | 0.996 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 1.221823e-01 | 0.913 | 0 | 0 |
| MAPK3 (ERK1) activation | R-HSA-110056 | 1.448168e-01 | 0.839 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 1.686925e-01 | 0.773 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 1.451711e-01 | 0.838 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 1.248716e-01 | 0.904 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 1.638925e-01 | 0.785 | 0 | 0 |
| Antigen processing: Ub, ATP-independent proteasomal degradation | R-HSA-9912633 | 1.638925e-01 | 0.785 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 1.396119e-01 | 0.855 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 1.195662e-01 | 0.922 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 1.452609e-01 | 0.838 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 1.473635e-01 | 0.832 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 1.001432e-01 | 0.999 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 1.597048e-01 | 0.797 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 1.589760e-01 | 0.799 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 1.028461e-01 | 0.988 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 9.353796e-02 | 1.029 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 1.009983e-01 | 0.996 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 1.372129e-01 | 0.863 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 1.448168e-01 | 0.839 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 1.028461e-01 | 0.988 | 0 | 0 |
| Regulation of IFNA/IFNB signaling | R-HSA-912694 | 1.550715e-01 | 0.809 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 1.265339e-01 | 0.898 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 9.636453e-02 | 1.016 | 0 | 0 |
| Dopamine receptors | R-HSA-390651 | 1.231916e-01 | 0.909 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in BCR signaling | R-HSA-8939245 | 1.574011e-01 | 0.803 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 1.152591e-01 | 0.938 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 1.009983e-01 | 0.996 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 9.992610e-02 | 1.000 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 1.537167e-01 | 0.813 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 1.537167e-01 | 0.813 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 1.537167e-01 | 0.813 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 1.537167e-01 | 0.813 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 1.084070e-01 | 0.965 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 1.354776e-01 | 0.868 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 1.172783e-01 | 0.931 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 1.589760e-01 | 0.799 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 1.240848e-01 | 0.906 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 1.231916e-01 | 0.909 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 1.365408e-01 | 0.865 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 1.644884e-01 | 0.784 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 1.172783e-01 | 0.931 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 1.227992e-01 | 0.911 | 0 | 0 |
| Prostacyclin signalling through prostacyclin receptor | R-HSA-392851 | 9.772937e-02 | 1.010 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 1.451711e-01 | 0.838 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 1.711997e-01 | 0.766 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 1.257861e-01 | 0.900 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 9.636453e-02 | 1.016 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 1.365408e-01 | 0.865 | 0 | 0 |
| PTK6 Regulates Proteins Involved in RNA Processing | R-HSA-8849468 | 1.574011e-01 | 0.803 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 1.221823e-01 | 0.913 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 1.108968e-01 | 0.955 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 1.638925e-01 | 0.785 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 1.028461e-01 | 0.988 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 1.323685e-01 | 0.878 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 1.108968e-01 | 0.955 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 9.478374e-02 | 1.023 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 1.606066e-01 | 0.794 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 1.451711e-01 | 0.838 | 0 | 0 |
| Inhibition of PKR | R-HSA-169131 | 1.823668e-01 | 0.739 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 1.574011e-01 | 0.803 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 1.221823e-01 | 0.913 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 1.221823e-01 | 0.913 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 1.248716e-01 | 0.904 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 1.711997e-01 | 0.766 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 1.135757e-01 | 0.945 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 1.714048e-01 | 0.766 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 1.537167e-01 | 0.813 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 1.461105e-01 | 0.835 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 1.473635e-01 | 0.832 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 9.595816e-02 | 1.018 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 1.555840e-01 | 0.808 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 9.742954e-02 | 1.011 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 1.432145e-01 | 0.844 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 1.273537e-01 | 0.895 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 1.068704e-01 | 0.971 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 1.432145e-01 | 0.844 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 1.432145e-01 | 0.844 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 9.302790e-02 | 1.031 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 9.184024e-02 | 1.037 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 1.681302e-01 | 0.774 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 1.391301e-01 | 0.857 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 1.076420e-01 | 0.968 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 9.184024e-02 | 1.037 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 1.573075e-01 | 0.803 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 1.473019e-01 | 0.832 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 1.105301e-01 | 0.957 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 1.010047e-01 | 0.996 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 1.473635e-01 | 0.832 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 1.473635e-01 | 0.832 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 1.806876e-01 | 0.743 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 1.574011e-01 | 0.803 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 9.426688e-02 | 1.026 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 1.248716e-01 | 0.904 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 1.009983e-01 | 0.996 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 1.738880e-01 | 0.760 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 1.132025e-01 | 0.946 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 1.711997e-01 | 0.766 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 1.574011e-01 | 0.803 | 0 | 0 |
| Butyrophilin (BTN) family interactions | R-HSA-8851680 | 1.221823e-01 | 0.913 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 1.452609e-01 | 0.838 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 1.473635e-01 | 0.832 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 1.067334e-01 | 0.972 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 1.441291e-01 | 0.841 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 1.638925e-01 | 0.785 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 1.287240e-01 | 0.890 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 1.448168e-01 | 0.839 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 1.638925e-01 | 0.785 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 9.636453e-02 | 1.016 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.426688e-02 | 1.026 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 1.105301e-01 | 0.957 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 1.396119e-01 | 0.855 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 1.711997e-01 | 0.766 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 1.789324e-01 | 0.747 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 1.703205e-01 | 0.769 | 0 | 0 |
| Response to metal ions | R-HSA-5660526 | 1.638925e-01 | 0.785 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 1.451711e-01 | 0.838 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 1.589760e-01 | 0.799 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 1.829289e-01 | 0.738 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 1.834235e-01 | 0.737 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 1.857708e-01 | 0.731 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 1.873514e-01 | 0.727 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 1.879427e-01 | 0.726 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 1.879427e-01 | 0.726 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 1.879815e-01 | 0.726 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 1.879815e-01 | 0.726 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 1.927980e-01 | 0.715 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 1.927980e-01 | 0.715 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 1.931025e-01 | 0.714 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 1.931025e-01 | 0.714 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 1.931025e-01 | 0.714 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 1.931025e-01 | 0.714 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 1.931025e-01 | 0.714 | 0 | 0 |
| Release of apoptotic factors from the mitochondria | R-HSA-111457 | 1.931025e-01 | 0.714 | 0 | 0 |
| CDC6 association with the ORC:origin complex | R-HSA-68689 | 1.931025e-01 | 0.714 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 1.931025e-01 | 0.714 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 1.931025e-01 | 0.714 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 1.931025e-01 | 0.714 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 1.936017e-01 | 0.713 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 1.950732e-01 | 0.710 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 1.950732e-01 | 0.710 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 1.991907e-01 | 0.701 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 1.994107e-01 | 0.700 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 1.994107e-01 | 0.700 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 1.999773e-01 | 0.699 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 2.012801e-01 | 0.696 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 2.032006e-01 | 0.692 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 2.032006e-01 | 0.692 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 2.036672e-01 | 0.691 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 2.036672e-01 | 0.691 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 2.036672e-01 | 0.691 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 2.052440e-01 | 0.688 | 0 | 0 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 2.052440e-01 | 0.688 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 2.052440e-01 | 0.688 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 2.052440e-01 | 0.688 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 2.052440e-01 | 0.688 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 2.052440e-01 | 0.688 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 2.052440e-01 | 0.688 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 2.134259e-01 | 0.671 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 2.170406e-01 | 0.663 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 2.170899e-01 | 0.663 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 2.170899e-01 | 0.663 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 2.188464e-01 | 0.660 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 2.188468e-01 | 0.660 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 2.188468e-01 | 0.660 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 2.193424e-01 | 0.659 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 2.193424e-01 | 0.659 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 2.193424e-01 | 0.659 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 2.193424e-01 | 0.659 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 2.193424e-01 | 0.659 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 2.239759e-01 | 0.650 | 0 | 0 |
| Pre-NOTCH Processing in Golgi | R-HSA-1912420 | 2.245254e-01 | 0.649 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 2.249006e-01 | 0.648 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 2.255797e-01 | 0.647 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 2.289319e-01 | 0.640 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 2.296970e-01 | 0.639 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 2.296970e-01 | 0.639 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 2.296970e-01 | 0.639 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 2.296970e-01 | 0.639 | 0 | 0 |
| G2/M DNA replication checkpoint | R-HSA-69478 | 2.296970e-01 | 0.639 | 0 | 0 |
| Toxicity of botulinum toxin type F (botF) | R-HSA-5250981 | 2.296970e-01 | 0.639 | 0 | 0 |
| Toxicity of botulinum toxin type D (botD) | R-HSA-5250955 | 2.296970e-01 | 0.639 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 2.313368e-01 | 0.636 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 2.344419e-01 | 0.630 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 2.348805e-01 | 0.629 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 2.348805e-01 | 0.629 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 2.380172e-01 | 0.623 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 2.407404e-01 | 0.618 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 2.407404e-01 | 0.618 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 2.407404e-01 | 0.618 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 2.412877e-01 | 0.617 | 0 | 0 |
| ER Quality Control Compartment (ERQC) | R-HSA-901032 | 2.412877e-01 | 0.617 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 2.424690e-01 | 0.615 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 2.424690e-01 | 0.615 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 2.424690e-01 | 0.615 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 2.441431e-01 | 0.612 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 2.457213e-01 | 0.610 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 2.457213e-01 | 0.610 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 2.457213e-01 | 0.610 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 2.457213e-01 | 0.610 | 0 | 0 |
| Reversible hydration of carbon dioxide | R-HSA-1475029 | 2.457213e-01 | 0.610 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 2.457213e-01 | 0.610 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 2.459001e-01 | 0.609 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 2.489624e-01 | 0.604 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 2.506474e-01 | 0.601 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 2.538096e-01 | 0.595 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 2.543177e-01 | 0.595 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 2.574382e-01 | 0.589 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 2.599108e-01 | 0.585 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH2 | R-HSA-5632928 | 2.606779e-01 | 0.584 | 0 | 0 |
| Defective SLC26A2 causes chondrodysplasias | R-HSA-3560792 | 2.606779e-01 | 0.584 | 0 | 0 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 2.606779e-01 | 0.584 | 0 | 0 |
| IKBKB deficiency causes SCID | R-HSA-5602636 | 2.606779e-01 | 0.584 | 0 | 0 |
| Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | R-HSA-5619111 | 2.606779e-01 | 0.584 | 0 | 0 |
| Signaling by TCF7L2 mutants | R-HSA-5339700 | 2.606779e-01 | 0.584 | 0 | 0 |
| TRAF3 deficiency - HSE | R-HSA-5602571 | 2.606779e-01 | 0.584 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 2.606779e-01 | 0.584 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 2.606779e-01 | 0.584 | 0 | 0 |
| Nef mediated downregulation of CD28 cell surface expression | R-HSA-164939 | 2.606779e-01 | 0.584 | 0 | 0 |
| Inhibition of Host mRNA Processing and RNA Silencing | R-HSA-168315 | 2.606779e-01 | 0.584 | 0 | 0 |
| NTRK3 as a dependence receptor | R-HSA-9603505 | 2.606779e-01 | 0.584 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 2.666863e-01 | 0.574 | 0 | 0 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | 2.666863e-01 | 0.574 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 2.666863e-01 | 0.574 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 2.666863e-01 | 0.574 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 2.666863e-01 | 0.574 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 2.666863e-01 | 0.574 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 2.666863e-01 | 0.574 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 2.666863e-01 | 0.574 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 2.666863e-01 | 0.574 | 0 | 0 |
| Nef Mediated CD4 Down-regulation | R-HSA-167590 | 2.666863e-01 | 0.574 | 0 | 0 |
| Netrin mediated repulsion signals | R-HSA-418886 | 2.666863e-01 | 0.574 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 2.666863e-01 | 0.574 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 2.666863e-01 | 0.574 | 0 | 0 |
| Synthesis of PIPs in the nucleus | R-HSA-8847453 | 2.666863e-01 | 0.574 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 2.676946e-01 | 0.572 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 2.676946e-01 | 0.572 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 2.676946e-01 | 0.572 | 0 | 0 |
| Retrograde neurotrophin signalling | R-HSA-177504 | 2.725556e-01 | 0.565 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 2.725556e-01 | 0.565 | 0 | 0 |
| Malate-aspartate shuttle | R-HSA-9856872 | 2.725556e-01 | 0.565 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 2.725556e-01 | 0.565 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 2.726656e-01 | 0.564 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 2.726656e-01 | 0.564 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 2.726656e-01 | 0.564 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 2.783047e-01 | 0.555 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 2.788550e-01 | 0.555 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 2.788550e-01 | 0.555 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 2.881206e-01 | 0.540 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 2.881206e-01 | 0.540 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 2.898147e-01 | 0.538 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 2.898147e-01 | 0.538 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 2.936465e-01 | 0.532 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 2.980609e-01 | 0.526 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 2.980609e-01 | 0.526 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 2.996751e-01 | 0.523 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 2.996751e-01 | 0.523 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 2.996751e-01 | 0.523 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 3.014242e-01 | 0.521 | 0 | 0 |
| Activated NTRK2 signals through FYN | R-HSA-9032500 | 3.036595e-01 | 0.518 | 0 | 0 |
| MET receptor recycling | R-HSA-8875656 | 3.036595e-01 | 0.518 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 3.036595e-01 | 0.518 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 3.079079e-01 | 0.512 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 3.121694e-01 | 0.506 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 3.121694e-01 | 0.506 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 3.121694e-01 | 0.506 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 3.121694e-01 | 0.506 | 0 | 0 |
| Ethanol oxidation | R-HSA-71384 | 3.121694e-01 | 0.506 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 3.129129e-01 | 0.505 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 3.174705e-01 | 0.498 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 3.186950e-01 | 0.497 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 3.189768e-01 | 0.496 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 3.194291e-01 | 0.496 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 3.194291e-01 | 0.496 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 3.269228e-01 | 0.486 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 3.314927e-01 | 0.480 | 0 | 0 |
| TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 3.314927e-01 | 0.480 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 3.314927e-01 | 0.480 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 3.314927e-01 | 0.480 | 0 | 0 |
| TGFBR2 Kinase Domain Mutants in Cancer | R-HSA-3645790 | 3.314927e-01 | 0.480 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 3.314927e-01 | 0.480 | 0 | 0 |
| Defective AHCY causes HMAHCHD | R-HSA-5578997 | 3.314927e-01 | 0.480 | 0 | 0 |
| Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | R-HSA-5655799 | 3.314927e-01 | 0.480 | 0 | 0 |
| Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization | R-HSA-180897 | 3.314927e-01 | 0.480 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 3.314927e-01 | 0.480 | 0 | 0 |
| Loss of Function of TGFBR2 in Cancer | R-HSA-3642278 | 3.314927e-01 | 0.480 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 3.314927e-01 | 0.480 | 0 | 0 |
| tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | R-HSA-9708296 | 3.314927e-01 | 0.480 | 0 | 0 |
| ATF6B (ATF6-beta) activates chaperones | R-HSA-8874177 | 3.314927e-01 | 0.480 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 3.369269e-01 | 0.472 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 3.369269e-01 | 0.472 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 3.370268e-01 | 0.472 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 3.370268e-01 | 0.472 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 3.371390e-01 | 0.472 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 3.402807e-01 | 0.468 | 0 | 0 |
| 5-Phosphoribose 1-diphosphate biosynthesis | R-HSA-73843 | 3.402807e-01 | 0.468 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 3.402807e-01 | 0.468 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 3.402807e-01 | 0.468 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 3.402807e-01 | 0.468 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 3.402807e-01 | 0.468 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 3.402807e-01 | 0.468 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 3.402807e-01 | 0.468 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 3.402807e-01 | 0.468 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 3.402807e-01 | 0.468 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 3.402807e-01 | 0.468 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 3.402807e-01 | 0.468 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 3.402807e-01 | 0.468 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 3.516014e-01 | 0.454 | 0 | 0 |
| SHC1 events in ERBB4 signaling | R-HSA-1250347 | 3.541552e-01 | 0.451 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 3.541552e-01 | 0.451 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 3.566749e-01 | 0.448 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 3.566749e-01 | 0.448 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 3.572382e-01 | 0.447 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 3.655307e-01 | 0.437 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 3.699207e-01 | 0.432 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 3.748518e-01 | 0.426 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 3.762783e-01 | 0.424 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 3.762783e-01 | 0.424 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 3.762783e-01 | 0.424 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 3.762783e-01 | 0.424 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 3.762783e-01 | 0.424 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 3.762783e-01 | 0.424 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 3.762783e-01 | 0.424 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 3.762783e-01 | 0.424 | 0 | 0 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | R-HSA-5140745 | 3.762783e-01 | 0.424 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 3.762783e-01 | 0.424 | 0 | 0 |
| Receptor Mediated Mitophagy | R-HSA-8934903 | 3.762783e-01 | 0.424 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 3.762783e-01 | 0.424 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 3.763619e-01 | 0.424 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 3.797918e-01 | 0.420 | 1 | 1 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 3.812427e-01 | 0.419 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 3.812427e-01 | 0.419 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 3.812427e-01 | 0.419 | 0 | 0 |
| Regulation of MITF-M dependent genes involved in metabolism | R-HSA-9854907 | 3.955284e-01 | 0.403 | 0 | 0 |
| Adrenaline signalling through Alpha-2 adrenergic receptor | R-HSA-392023 | 3.955284e-01 | 0.403 | 0 | 0 |
| MET activates STAT3 | R-HSA-8875791 | 3.955284e-01 | 0.403 | 0 | 0 |
| Intracellular oxygen transport | R-HSA-8981607 | 3.955284e-01 | 0.403 | 0 | 0 |
| Histamine receptors | R-HSA-390650 | 3.955284e-01 | 0.403 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 4.001125e-01 | 0.398 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 4.022594e-01 | 0.395 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 4.022594e-01 | 0.395 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 4.022594e-01 | 0.395 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 4.080695e-01 | 0.389 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 4.080695e-01 | 0.389 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 4.110990e-01 | 0.386 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 4.114359e-01 | 0.386 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 4.114359e-01 | 0.386 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 4.114359e-01 | 0.386 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 4.114359e-01 | 0.386 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 4.114359e-01 | 0.386 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 4.114359e-01 | 0.386 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 4.114359e-01 | 0.386 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 4.142692e-01 | 0.383 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 4.156529e-01 | 0.381 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 4.156529e-01 | 0.381 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 4.156529e-01 | 0.381 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 4.214493e-01 | 0.375 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 4.245737e-01 | 0.372 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 4.245737e-01 | 0.372 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 4.245737e-01 | 0.372 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 4.245737e-01 | 0.372 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 4.245737e-01 | 0.372 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 4.245737e-01 | 0.372 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.345330e-01 | 0.362 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 4.345330e-01 | 0.362 | 0 | 0 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 4.345330e-01 | 0.362 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 4.351635e-01 | 0.361 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 4.417368e-01 | 0.355 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 4.427423e-01 | 0.354 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 4.427423e-01 | 0.354 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 4.455842e-01 | 0.351 | 0 | 0 |
| PI3K events in ERBB4 signaling | R-HSA-1250342 | 4.455842e-01 | 0.351 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 4.455842e-01 | 0.351 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 4.455842e-01 | 0.351 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 4.455842e-01 | 0.351 | 0 | 0 |
| POLB-Dependent Long Patch Base Excision Repair | R-HSA-110362 | 4.455842e-01 | 0.351 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 4.455842e-01 | 0.351 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 4.455842e-01 | 0.351 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 4.455842e-01 | 0.351 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 4.455842e-01 | 0.351 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 4.466726e-01 | 0.350 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 4.466726e-01 | 0.350 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 4.466726e-01 | 0.350 | 0 | 0 |
| HCN channels | R-HSA-1296061 | 4.534335e-01 | 0.343 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 4.534335e-01 | 0.343 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 4.534335e-01 | 0.343 | 0 | 0 |
| Signaling by MAP2K mutants | R-HSA-9652169 | 4.534335e-01 | 0.343 | 0 | 0 |
| Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | R-HSA-69200 | 4.534335e-01 | 0.343 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 4.534335e-01 | 0.343 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 4.534335e-01 | 0.343 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 4.534335e-01 | 0.343 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 4.534335e-01 | 0.343 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 4.534335e-01 | 0.343 | 0 | 0 |
| Toxicity of tetanus toxin (tetX) | R-HSA-5250982 | 4.534335e-01 | 0.343 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 4.545266e-01 | 0.342 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 4.601866e-01 | 0.337 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 4.605435e-01 | 0.337 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 4.605435e-01 | 0.337 | 0 | 0 |
| Formation of ATP by chemiosmotic coupling | R-HSA-163210 | 4.605435e-01 | 0.337 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 4.605435e-01 | 0.337 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 4.605435e-01 | 0.337 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 4.605435e-01 | 0.337 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 4.631004e-01 | 0.334 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 4.646850e-01 | 0.333 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 4.684997e-01 | 0.329 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 4.736326e-01 | 0.325 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 4.736326e-01 | 0.325 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 4.737026e-01 | 0.324 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 4.774915e-01 | 0.321 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 4.785942e-01 | 0.320 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 4.785942e-01 | 0.320 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 4.785942e-01 | 0.320 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 4.785942e-01 | 0.320 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 4.785942e-01 | 0.320 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 4.785942e-01 | 0.320 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 4.785942e-01 | 0.320 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 4.785942e-01 | 0.320 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 4.785942e-01 | 0.320 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 4.785942e-01 | 0.320 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 4.785942e-01 | 0.320 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 4.785942e-01 | 0.320 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 4.860235e-01 | 0.313 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 4.860235e-01 | 0.313 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 4.860235e-01 | 0.313 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 4.860235e-01 | 0.313 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 4.926548e-01 | 0.307 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 4.926548e-01 | 0.307 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 4.926548e-01 | 0.307 | 0 | 0 |
| Regulation of MITF-M dependent genes involved in invasion | R-HSA-9854909 | 5.057948e-01 | 0.296 | 0 | 0 |
| Activation of AMPA receptors | R-HSA-399710 | 5.057948e-01 | 0.296 | 0 | 0 |
| NTRK2 activates RAC1 | R-HSA-9032759 | 5.057948e-01 | 0.296 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 5.057948e-01 | 0.296 | 0 | 0 |
| G2 Phase | R-HSA-68911 | 5.057948e-01 | 0.296 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 5.057948e-01 | 0.296 | 0 | 0 |
| Defective F9 activation | R-HSA-9673221 | 5.057948e-01 | 0.296 | 0 | 0 |
| Enhanced binding of GP1BA variant to VWF multimer:collagen | R-HSA-9845620 | 5.057948e-01 | 0.296 | 0 | 0 |
| Defective binding of VWF variant to GPIb:IX:V | R-HSA-9846298 | 5.057948e-01 | 0.296 | 0 | 0 |
| IRF3 mediated activation of type 1 IFN | R-HSA-1606341 | 5.057948e-01 | 0.296 | 0 | 0 |
| Resolution of AP sites via the single-nucleotide replacement pathway | R-HSA-110381 | 5.057948e-01 | 0.296 | 0 | 0 |
| PTK6 Down-Regulation | R-HSA-8849472 | 5.057948e-01 | 0.296 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in interleukin signaling | R-HSA-8939247 | 5.057948e-01 | 0.296 | 0 | 0 |
| Muscarinic acetylcholine receptors | R-HSA-390648 | 5.057948e-01 | 0.296 | 0 | 0 |
| Pyrophosphate hydrolysis | R-HSA-71737 | 5.057948e-01 | 0.296 | 0 | 0 |
| Toxicity of botulinum toxin type G (botG) | R-HSA-5250989 | 5.057948e-01 | 0.296 | 0 | 0 |
| Assembly of Viral Components at the Budding Site | R-HSA-168316 | 5.057948e-01 | 0.296 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 5.103706e-01 | 0.292 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 5.109070e-01 | 0.292 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 5.109070e-01 | 0.292 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 5.111393e-01 | 0.291 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 5.113496e-01 | 0.291 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 5.113496e-01 | 0.291 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 5.272476e-01 | 0.278 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 5.297563e-01 | 0.276 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 5.297563e-01 | 0.276 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy | R-HSA-9857377 | 5.351384e-01 | 0.272 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 5.351384e-01 | 0.272 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 5.408467e-01 | 0.267 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 5.408467e-01 | 0.267 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 5.408467e-01 | 0.267 | 0 | 0 |
| Beta oxidation of hexanoyl-CoA to butanoyl-CoA | R-HSA-77350 | 5.408467e-01 | 0.267 | 0 | 0 |
| Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | R-HSA-77310 | 5.408467e-01 | 0.267 | 0 | 0 |
| Beta oxidation of octanoyl-CoA to hexanoyl-CoA | R-HSA-77348 | 5.408467e-01 | 0.267 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 5.408467e-01 | 0.267 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 5.408467e-01 | 0.267 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 5.424944e-01 | 0.266 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 5.479500e-01 | 0.261 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 5.521470e-01 | 0.258 | 0 | 0 |
| Plus-strand DNA synthesis | R-HSA-164525 | 5.531427e-01 | 0.257 | 0 | 0 |
| Nef Mediated CD8 Down-regulation | R-HSA-182218 | 5.531427e-01 | 0.257 | 0 | 0 |
| Signaling by Overexpressed Wild-Type EGFR in Cancer | R-HSA-5638302 | 5.531427e-01 | 0.257 | 0 | 0 |
| PTK6 Regulates Cell Cycle | R-HSA-8849470 | 5.531427e-01 | 0.257 | 0 | 0 |
| Inhibition of Signaling by Overexpressed EGFR | R-HSA-5638303 | 5.531427e-01 | 0.257 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 5.531427e-01 | 0.257 | 0 | 0 |
| Toxicity of botulinum toxin type E (botE) | R-HSA-5250992 | 5.531427e-01 | 0.257 | 0 | 0 |
| Pentose phosphate pathway disease | R-HSA-6791465 | 5.531427e-01 | 0.257 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 5.531427e-01 | 0.257 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 5.531427e-01 | 0.257 | 0 | 0 |
| Formation of the Editosome | R-HSA-75094 | 5.531427e-01 | 0.257 | 0 | 0 |
| Defects of platelet adhesion to exposed collagen | R-HSA-9823587 | 5.531427e-01 | 0.257 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 5.531427e-01 | 0.257 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 5.531427e-01 | 0.257 | 0 | 0 |
| SLC15A4:TASL-dependent IRF5 activation | R-HSA-9860276 | 5.531427e-01 | 0.257 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 5.575337e-01 | 0.254 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 5.586725e-01 | 0.253 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 5.639909e-01 | 0.249 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 5.699802e-01 | 0.244 | 0 | 0 |
| Adenylate cyclase inhibitory pathway | R-HSA-170670 | 5.699802e-01 | 0.244 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 5.699802e-01 | 0.244 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 5.699802e-01 | 0.244 | 0 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 5.769601e-01 | 0.239 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 5.893108e-01 | 0.230 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 5.912572e-01 | 0.228 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 5.912572e-01 | 0.228 | 0 | 0 |
| Signaling by LTK in cancer | R-HSA-9842640 | 5.959568e-01 | 0.225 | 0 | 0 |
| Chylomicron clearance | R-HSA-8964026 | 5.959568e-01 | 0.225 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 5.959568e-01 | 0.225 | 0 | 0 |
| Uncoating of the HIV Virion | R-HSA-162585 | 5.959568e-01 | 0.225 | 0 | 0 |
| MET Receptor Activation | R-HSA-6806942 | 5.959568e-01 | 0.225 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 5.959568e-01 | 0.225 | 0 | 0 |
| Lactose synthesis | R-HSA-5653890 | 5.959568e-01 | 0.225 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 5.959568e-01 | 0.225 | 0 | 0 |
| VLDL assembly | R-HSA-8866423 | 5.959568e-01 | 0.225 | 0 | 0 |
| HDL clearance | R-HSA-8964011 | 5.959568e-01 | 0.225 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 5.977486e-01 | 0.223 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 5.977486e-01 | 0.223 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 5.977486e-01 | 0.223 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 5.977486e-01 | 0.223 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 5.977486e-01 | 0.223 | 0 | 0 |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | R-HSA-434316 | 5.977486e-01 | 0.223 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 5.999886e-01 | 0.222 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 6.035114e-01 | 0.219 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 6.035114e-01 | 0.219 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 6.100381e-01 | 0.215 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 6.241459e-01 | 0.205 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 6.241459e-01 | 0.205 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 6.241459e-01 | 0.205 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 6.241459e-01 | 0.205 | 0 | 0 |
| Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | R-HSA-77346 | 6.241459e-01 | 0.205 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 6.241459e-01 | 0.205 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 6.247677e-01 | 0.204 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 6.247677e-01 | 0.204 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 6.247677e-01 | 0.204 | 0 | 0 |
| Urea cycle | R-HSA-70635 | 6.247677e-01 | 0.204 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 6.282777e-01 | 0.202 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 6.308192e-01 | 0.200 | 1 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 6.327865e-01 | 0.199 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 6.327865e-01 | 0.199 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 6.327865e-01 | 0.199 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 6.327865e-01 | 0.199 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 6.346712e-01 | 0.197 | 0 | 0 |
| PP2A-mediated dephosphorylation of key metabolic factors | R-HSA-163767 | 6.346712e-01 | 0.197 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 6.346712e-01 | 0.197 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 6.346712e-01 | 0.197 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 6.346712e-01 | 0.197 | 0 | 0 |
| mRNA Editing: C to U Conversion | R-HSA-72200 | 6.346712e-01 | 0.197 | 0 | 0 |
| PTK6 Expression | R-HSA-8849473 | 6.346712e-01 | 0.197 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 6.346712e-01 | 0.197 | 0 | 0 |
| LDL remodeling | R-HSA-8964041 | 6.346712e-01 | 0.197 | 0 | 0 |
| TGFBR3 regulates TGF-beta signaling | R-HSA-9839389 | 6.346712e-01 | 0.197 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 6.452282e-01 | 0.190 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 6.452282e-01 | 0.190 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 6.452282e-01 | 0.190 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 6.452282e-01 | 0.190 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 6.487006e-01 | 0.188 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 6.491800e-01 | 0.188 | 0 | 0 |
| Sulfide oxidation to sulfate | R-HSA-1614517 | 6.491800e-01 | 0.188 | 0 | 0 |
| Choline catabolism | R-HSA-6798163 | 6.491800e-01 | 0.188 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 6.491800e-01 | 0.188 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 6.491800e-01 | 0.188 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 6.572205e-01 | 0.182 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 6.630813e-01 | 0.178 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 6.630813e-01 | 0.178 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 6.630813e-01 | 0.178 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 6.648851e-01 | 0.177 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 6.648851e-01 | 0.177 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 6.648851e-01 | 0.177 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 6.648851e-01 | 0.177 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 6.659792e-01 | 0.177 | 0 | 0 |
| Reverse Transcription of HIV RNA | R-HSA-162589 | 6.696781e-01 | 0.174 | 0 | 0 |
| Minus-strand DNA synthesis | R-HSA-164516 | 6.696781e-01 | 0.174 | 0 | 0 |
| RSK activation | R-HSA-444257 | 6.696781e-01 | 0.174 | 0 | 0 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 6.696781e-01 | 0.174 | 0 | 0 |
| Activated NTRK2 signals through PI3K | R-HSA-9028335 | 6.696781e-01 | 0.174 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 6.696781e-01 | 0.174 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 6.696781e-01 | 0.174 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 6.696781e-01 | 0.174 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 6.696781e-01 | 0.174 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 6.696781e-01 | 0.174 | 0 | 0 |
| SLC-mediated bile acid transport | R-HSA-9958517 | 6.696781e-01 | 0.174 | 0 | 0 |
| Alpha-defensins | R-HSA-1462054 | 6.696781e-01 | 0.174 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 6.696781e-01 | 0.174 | 0 | 0 |
| Toxicity of botulinum toxin type B (botB) | R-HSA-5250958 | 6.696781e-01 | 0.174 | 0 | 0 |
| Interleukin-23 signaling | R-HSA-9020933 | 6.696781e-01 | 0.174 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 6.728696e-01 | 0.172 | 0 | 0 |
| Organic anion transport by SLC5/17/25 transporters | R-HSA-428643 | 6.728696e-01 | 0.172 | 0 | 0 |
| Nephron development | R-HSA-9831926 | 6.728696e-01 | 0.172 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 6.796044e-01 | 0.168 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 6.796278e-01 | 0.168 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 6.837363e-01 | 0.165 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 6.837363e-01 | 0.165 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 6.932183e-01 | 0.159 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 6.936913e-01 | 0.159 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 6.948743e-01 | 0.158 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 6.952427e-01 | 0.158 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 6.952427e-01 | 0.158 | 0 | 0 |
| mRNA decay by 3' to 5' exoribonuclease | R-HSA-429958 | 6.952427e-01 | 0.158 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 6.952427e-01 | 0.158 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 6.952427e-01 | 0.158 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 6.955975e-01 | 0.158 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 6.972783e-01 | 0.157 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 7.000609e-01 | 0.155 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 7.013324e-01 | 0.154 | 0 | 0 |
| Toxicity of botulinum toxin type A (botA) | R-HSA-5250968 | 7.013324e-01 | 0.154 | 0 | 0 |
| APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | R-HSA-5649702 | 7.013324e-01 | 0.154 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 7.013324e-01 | 0.154 | 0 | 0 |
| MAPK1 (ERK2) activation | R-HSA-112411 | 7.013324e-01 | 0.154 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 7.013324e-01 | 0.154 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 7.013324e-01 | 0.154 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 7.013324e-01 | 0.154 | 0 | 0 |
| Expression of NOTCH2NL genes | R-HSA-9911233 | 7.013324e-01 | 0.154 | 0 | 0 |
| Regulation of NPAS4 gene transcription | R-HSA-9768777 | 7.013324e-01 | 0.154 | 0 | 0 |
| mRNA Editing | R-HSA-75072 | 7.013324e-01 | 0.154 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 7.013324e-01 | 0.154 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 7.013324e-01 | 0.154 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 7.017844e-01 | 0.154 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 7.050129e-01 | 0.152 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 7.056876e-01 | 0.151 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 7.072094e-01 | 0.150 | 0 | 0 |
| Regulation of PD-L1(CD274) translation | R-HSA-9909620 | 7.163338e-01 | 0.145 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 7.163338e-01 | 0.145 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 7.163338e-01 | 0.145 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 7.163338e-01 | 0.145 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 7.163338e-01 | 0.145 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 7.163338e-01 | 0.145 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 7.163338e-01 | 0.145 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 7.163338e-01 | 0.145 | 0 | 0 |
| Creatine metabolism | R-HSA-71288 | 7.163338e-01 | 0.145 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 7.173683e-01 | 0.144 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 7.174782e-01 | 0.144 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 7.190359e-01 | 0.143 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 7.207474e-01 | 0.142 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 7.207474e-01 | 0.142 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 7.207474e-01 | 0.142 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 7.258037e-01 | 0.139 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 7.258037e-01 | 0.139 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 7.287314e-01 | 0.137 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 7.294042e-01 | 0.137 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 7.299550e-01 | 0.137 | 0 | 0 |
| Cross-presentation of particulate exogenous antigens (phagosomes) | R-HSA-1236973 | 7.299550e-01 | 0.137 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 7.299550e-01 | 0.137 | 0 | 0 |
| Defective factor IX causes hemophilia B | R-HSA-9668250 | 7.299550e-01 | 0.137 | 0 | 0 |
| Metal sequestration by antimicrobial proteins | R-HSA-6799990 | 7.299550e-01 | 0.137 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 7.299550e-01 | 0.137 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 7.338321e-01 | 0.134 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 7.338321e-01 | 0.134 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 7.340672e-01 | 0.134 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 7.340672e-01 | 0.134 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 7.355013e-01 | 0.133 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 7.355013e-01 | 0.133 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 7.355013e-01 | 0.133 | 0 | 0 |
| Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 7.361833e-01 | 0.133 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 7.400447e-01 | 0.131 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 7.511939e-01 | 0.124 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 7.537175e-01 | 0.123 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 7.548353e-01 | 0.122 | 0 | 0 |
| Ribavirin ADME | R-HSA-9755088 | 7.548353e-01 | 0.122 | 0 | 0 |
| vRNP Assembly | R-HSA-192905 | 7.558361e-01 | 0.122 | 0 | 0 |
| vRNA Synthesis | R-HSA-192814 | 7.558361e-01 | 0.122 | 0 | 0 |
| Chylomicron assembly | R-HSA-8963888 | 7.558361e-01 | 0.122 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 7.558361e-01 | 0.122 | 0 | 0 |
| Inorganic anion exchange by SLC26 transporters | R-HSA-427601 | 7.558361e-01 | 0.122 | 0 | 0 |
| Suppression of apoptosis | R-HSA-9635465 | 7.558361e-01 | 0.122 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 7.558361e-01 | 0.122 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 7.563528e-01 | 0.121 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 7.651020e-01 | 0.116 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 7.703859e-01 | 0.113 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 7.723369e-01 | 0.112 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 7.723369e-01 | 0.112 | 0 | 0 |
| Neurotoxicity of clostridium toxins | R-HSA-168799 | 7.723369e-01 | 0.112 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 7.723369e-01 | 0.112 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 7.751522e-01 | 0.111 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 7.752644e-01 | 0.111 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 7.775133e-01 | 0.109 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 7.792382e-01 | 0.108 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 7.792382e-01 | 0.108 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 7.792382e-01 | 0.108 | 0 | 0 |
| ERKs are inactivated | R-HSA-202670 | 7.792382e-01 | 0.108 | 0 | 0 |
| Viral RNP Complexes in the Host Cell Nucleus | R-HSA-168330 | 7.792382e-01 | 0.108 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 7.803268e-01 | 0.108 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 7.803268e-01 | 0.108 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 7.803268e-01 | 0.108 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 7.803268e-01 | 0.108 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 7.816833e-01 | 0.107 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 7.887374e-01 | 0.103 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 7.887374e-01 | 0.103 | 0 | 0 |
| Free fatty acids regulate insulin secretion | R-HSA-400451 | 7.887374e-01 | 0.103 | 0 | 0 |
| Interleukin-20 family signaling | R-HSA-8854691 | 7.887374e-01 | 0.103 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 8.003985e-01 | 0.097 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 8.003985e-01 | 0.097 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 8.003985e-01 | 0.097 | 0 | 0 |
| Beta oxidation of myristoyl-CoA to lauroyl-CoA | R-HSA-77285 | 8.003985e-01 | 0.097 | 0 | 0 |
| Beta oxidation of palmitoyl-CoA to myristoyl-CoA | R-HSA-77305 | 8.003985e-01 | 0.097 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 8.003985e-01 | 0.097 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 8.003985e-01 | 0.097 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 8.003985e-01 | 0.097 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 8.003985e-01 | 0.097 | 0 | 0 |
| Acetylation | R-HSA-156582 | 8.003985e-01 | 0.097 | 0 | 0 |
| Activated NTRK2 signals through FRS2 and FRS3 | R-HSA-9028731 | 8.003985e-01 | 0.097 | 0 | 0 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 8.003985e-01 | 0.097 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 8.003985e-01 | 0.097 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 8.003985e-01 | 0.097 | 0 | 0 |
| Erythrocytes take up oxygen and release carbon dioxide | R-HSA-1247673 | 8.003985e-01 | 0.097 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 8.003985e-01 | 0.097 | 0 | 0 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 8.040869e-01 | 0.095 | 0 | 0 |
| Mitochondrial RNA degradation | R-HSA-9836573 | 8.040869e-01 | 0.095 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 8.040869e-01 | 0.095 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 8.065866e-01 | 0.093 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 8.129969e-01 | 0.090 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 8.129969e-01 | 0.090 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 8.138588e-01 | 0.089 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 8.138588e-01 | 0.089 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 8.181726e-01 | 0.087 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 8.184362e-01 | 0.087 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 8.184362e-01 | 0.087 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 8.184362e-01 | 0.087 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 8.184362e-01 | 0.087 | 0 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 8.184362e-01 | 0.087 | 0 | 0 |
| Adenylate cyclase activating pathway | R-HSA-170660 | 8.195317e-01 | 0.086 | 0 | 0 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | R-HSA-9661069 | 8.195317e-01 | 0.086 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 8.195317e-01 | 0.086 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 8.195317e-01 | 0.086 | 0 | 0 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | R-HSA-9659787 | 8.195317e-01 | 0.086 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 8.195317e-01 | 0.086 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 8.205248e-01 | 0.086 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 8.312209e-01 | 0.080 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 8.318025e-01 | 0.080 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 8.318025e-01 | 0.080 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 8.318360e-01 | 0.080 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 8.318360e-01 | 0.080 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 8.318360e-01 | 0.080 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 8.318360e-01 | 0.080 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 8.342908e-01 | 0.079 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 8.368318e-01 | 0.077 | 0 | 0 |
| Formation of the active cofactor, UDP-glucuronate | R-HSA-173599 | 8.368318e-01 | 0.077 | 0 | 0 |
| Prolactin receptor signaling | R-HSA-1170546 | 8.368318e-01 | 0.077 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 8.368318e-01 | 0.077 | 0 | 0 |
| Acyl chain remodeling of CL | R-HSA-1482798 | 8.368318e-01 | 0.077 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 8.396119e-01 | 0.076 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 8.409770e-01 | 0.075 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 8.422821e-01 | 0.075 | 0 | 0 |
| Maturation of hRSV A proteins | R-HSA-9828806 | 8.443363e-01 | 0.073 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 8.512025e-01 | 0.070 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 8.512025e-01 | 0.070 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 8.512025e-01 | 0.070 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 8.524745e-01 | 0.069 | 0 | 0 |
| Protein lipoylation | R-HSA-9857492 | 8.524745e-01 | 0.069 | 0 | 0 |
| Telomere C-strand synthesis initiation | R-HSA-174430 | 8.524745e-01 | 0.069 | 0 | 0 |
| p38MAPK events | R-HSA-171007 | 8.524745e-01 | 0.069 | 0 | 0 |
| Beta oxidation of butanoyl-CoA to acetyl-CoA | R-HSA-77352 | 8.524745e-01 | 0.069 | 0 | 0 |
| Lysosphingolipid and LPA receptors | R-HSA-419408 | 8.524745e-01 | 0.069 | 0 | 0 |
| Transport and metabolism of PAPS | R-HSA-174362 | 8.524745e-01 | 0.069 | 0 | 0 |
| Other semaphorin interactions | R-HSA-416700 | 8.524745e-01 | 0.069 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 8.552937e-01 | 0.068 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 8.559865e-01 | 0.068 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 8.608497e-01 | 0.065 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 8.625368e-01 | 0.064 | 0 | 0 |
| Defective GALNT12 causes CRCS1 | R-HSA-5083636 | 8.666184e-01 | 0.062 | 0 | 0 |
| Defective GALNT3 causes HFTC | R-HSA-5083625 | 8.666184e-01 | 0.062 | 0 | 0 |
| Entry of Influenza Virion into Host Cell via Endocytosis | R-HSA-168275 | 8.666184e-01 | 0.062 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 8.666184e-01 | 0.062 | 0 | 0 |
| Activation of the phototransduction cascade | R-HSA-2485179 | 8.666184e-01 | 0.062 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 8.666184e-01 | 0.062 | 0 | 0 |
| Fructose catabolism | R-HSA-70350 | 8.666184e-01 | 0.062 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 8.666184e-01 | 0.062 | 0 | 0 |
| Mitochondrial Uncoupling | R-HSA-166187 | 8.666184e-01 | 0.062 | 0 | 0 |
| Attachment and Entry | R-HSA-9678110 | 8.666184e-01 | 0.062 | 0 | 0 |
| Virus Assembly and Release | R-HSA-168268 | 8.666184e-01 | 0.062 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 8.668346e-01 | 0.062 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 8.668346e-01 | 0.062 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 8.699432e-01 | 0.061 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 8.699432e-01 | 0.061 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 8.699432e-01 | 0.061 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 8.721195e-01 | 0.059 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 8.725054e-01 | 0.059 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 8.769273e-01 | 0.057 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 8.769273e-01 | 0.057 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 8.769273e-01 | 0.057 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 8.769273e-01 | 0.057 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 8.794069e-01 | 0.056 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 8.794069e-01 | 0.056 | 0 | 0 |
| Glycine degradation | R-HSA-6783984 | 8.794069e-01 | 0.056 | 0 | 0 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 8.794069e-01 | 0.056 | 0 | 0 |
| Fibronectin matrix formation | R-HSA-1566977 | 8.794069e-01 | 0.056 | 0 | 0 |
| Transcriptional regulation of testis differentiation | R-HSA-9690406 | 8.794069e-01 | 0.056 | 0 | 0 |
| mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | R-HSA-77288 | 8.794069e-01 | 0.056 | 0 | 0 |
| Passive transport by Aquaporins | R-HSA-432047 | 8.794069e-01 | 0.056 | 0 | 0 |
| tRNA modification in the mitochondrion | R-HSA-6787450 | 8.794069e-01 | 0.056 | 0 | 0 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | R-HSA-9651496 | 8.794069e-01 | 0.056 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 8.824829e-01 | 0.054 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 8.863097e-01 | 0.052 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 8.866248e-01 | 0.052 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 8.909700e-01 | 0.050 | 0 | 0 |
| Defective C1GALT1C1 causes TNPS | R-HSA-5083632 | 8.909700e-01 | 0.050 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 8.909700e-01 | 0.050 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 8.909700e-01 | 0.050 | 0 | 0 |
| GDP-fucose biosynthesis | R-HSA-6787639 | 8.909700e-01 | 0.050 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 8.909700e-01 | 0.050 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 8.915693e-01 | 0.050 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 8.921398e-01 | 0.050 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 8.975241e-01 | 0.047 | 0 | 0 |
| Degradation of cysteine and homocysteine | R-HSA-1614558 | 9.012647e-01 | 0.045 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 9.014250e-01 | 0.045 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 9.014250e-01 | 0.045 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 9.014250e-01 | 0.045 | 0 | 0 |
| PKA activation | R-HSA-163615 | 9.014250e-01 | 0.045 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 9.014250e-01 | 0.045 | 0 | 0 |
| Tie2 Signaling | R-HSA-210993 | 9.014250e-01 | 0.045 | 0 | 0 |
| Vitamin D (calciferol) metabolism | R-HSA-196791 | 9.014250e-01 | 0.045 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 9.014250e-01 | 0.045 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 9.031153e-01 | 0.044 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 9.031153e-01 | 0.044 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 9.043747e-01 | 0.044 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.043747e-01 | 0.044 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 9.093915e-01 | 0.041 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 9.102608e-01 | 0.041 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 9.102840e-01 | 0.041 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 9.106198e-01 | 0.041 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 9.106198e-01 | 0.041 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 9.106198e-01 | 0.041 | 0 | 0 |
| Pyrimidine biosynthesis | R-HSA-500753 | 9.108780e-01 | 0.041 | 0 | 0 |
| Erythrocytes take up carbon dioxide and release oxygen | R-HSA-1237044 | 9.108780e-01 | 0.041 | 0 | 0 |
| O2/CO2 exchange in erythrocytes | R-HSA-1480926 | 9.108780e-01 | 0.041 | 0 | 0 |
| Diseases of hemostasis | R-HSA-9671793 | 9.108780e-01 | 0.041 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 9.108780e-01 | 0.041 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 9.158224e-01 | 0.038 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 9.175766e-01 | 0.037 | 0 | 0 |
| RA biosynthesis pathway | R-HSA-5365859 | 9.175766e-01 | 0.037 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 9.194250e-01 | 0.036 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 9.195112e-01 | 0.036 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 9.210739e-01 | 0.036 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 9.210739e-01 | 0.036 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 9.240217e-01 | 0.034 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 9.240217e-01 | 0.034 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 9.240217e-01 | 0.034 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 9.271528e-01 | 0.033 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 9.271528e-01 | 0.033 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 9.271528e-01 | 0.033 | 0 | 0 |
| Phenylalanine metabolism | R-HSA-8964208 | 9.271528e-01 | 0.033 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 9.271528e-01 | 0.033 | 0 | 0 |
| Abacavir metabolism | R-HSA-2161541 | 9.271528e-01 | 0.033 | 0 | 0 |
| Vitamin C (ascorbate) metabolism | R-HSA-196836 | 9.271528e-01 | 0.033 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 9.299892e-01 | 0.032 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 9.307031e-01 | 0.031 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 9.307031e-01 | 0.031 | 0 | 0 |
| FRS-mediated FGFR3 signaling | R-HSA-5654706 | 9.341399e-01 | 0.030 | 0 | 0 |
| Metabolism of Angiotensinogen to Angiotensins | R-HSA-2022377 | 9.341399e-01 | 0.030 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 9.351080e-01 | 0.029 | 0 | 0 |
| Voltage gated Potassium channels | R-HSA-1296072 | 9.355115e-01 | 0.029 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.392573e-01 | 0.027 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 9.404571e-01 | 0.027 | 0 | 0 |
| FRS-mediated FGFR4 signaling | R-HSA-5654712 | 9.404571e-01 | 0.027 | 0 | 0 |
| WNT ligand biogenesis and trafficking | R-HSA-3238698 | 9.404571e-01 | 0.027 | 0 | 0 |
| Cellular hexose transport | R-HSA-189200 | 9.404571e-01 | 0.027 | 0 | 0 |
| Fructose metabolism | R-HSA-5652084 | 9.404571e-01 | 0.027 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 9.404571e-01 | 0.027 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 9.429417e-01 | 0.026 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.436711e-01 | 0.025 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.443596e-01 | 0.025 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 9.453403e-01 | 0.024 | 0 | 0 |
| Termination of O-glycan biosynthesis | R-HSA-977068 | 9.461688e-01 | 0.024 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 9.461688e-01 | 0.024 | 0 | 0 |
| Mitochondrial mRNA modification | R-HSA-9937008 | 9.461688e-01 | 0.024 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.461697e-01 | 0.024 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.462477e-01 | 0.024 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.468394e-01 | 0.024 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 9.497027e-01 | 0.022 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.497027e-01 | 0.022 | 0 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 9.513328e-01 | 0.022 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 9.513328e-01 | 0.022 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 9.513328e-01 | 0.022 | 0 | 0 |
| Complex III assembly | R-HSA-9865881 | 9.513328e-01 | 0.022 | 0 | 0 |
| TNFs bind their physiological receptors | R-HSA-5669034 | 9.513328e-01 | 0.022 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.519581e-01 | 0.021 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 9.560018e-01 | 0.020 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 9.560018e-01 | 0.020 | 0 | 0 |
| Alpha-oxidation of phytanate | R-HSA-389599 | 9.560018e-01 | 0.020 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 9.560018e-01 | 0.020 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 9.574506e-01 | 0.019 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 9.574506e-01 | 0.019 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 9.574506e-01 | 0.019 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 9.574506e-01 | 0.019 | 0 | 0 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 9.574506e-01 | 0.019 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 9.575034e-01 | 0.019 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 9.586847e-01 | 0.018 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.594639e-01 | 0.018 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 9.602231e-01 | 0.018 | 0 | 0 |
| Linoleic acid (LA) metabolism | R-HSA-2046105 | 9.602231e-01 | 0.018 | 0 | 0 |
| Abacavir ADME | R-HSA-2161522 | 9.602231e-01 | 0.018 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 9.602231e-01 | 0.018 | 0 | 0 |
| Synthesis of IP2, IP, and Ins in the cytosol | R-HSA-1855183 | 9.602231e-01 | 0.018 | 0 | 0 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 9.608822e-01 | 0.017 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 9.615854e-01 | 0.017 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.615854e-01 | 0.017 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 9.640396e-01 | 0.016 | 0 | 0 |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | R-HSA-83936 | 9.640396e-01 | 0.016 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 9.640473e-01 | 0.016 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.643692e-01 | 0.016 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.655802e-01 | 0.015 | 0 | 0 |
| FRS-mediated FGFR2 signaling | R-HSA-5654700 | 9.674901e-01 | 0.014 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.693762e-01 | 0.014 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 9.696547e-01 | 0.013 | 0 | 0 |
| mitochondrial fatty acid beta-oxidation of saturated fatty acids | R-HSA-77286 | 9.696547e-01 | 0.013 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.696547e-01 | 0.013 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 9.704835e-01 | 0.013 | 0 | 0 |
| Thyroxine biosynthesis | R-HSA-209968 | 9.706097e-01 | 0.013 | 0 | 0 |
| Activation of Matrix Metalloproteinases | R-HSA-1592389 | 9.706097e-01 | 0.013 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 9.721324e-01 | 0.012 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 9.721324e-01 | 0.012 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 9.734301e-01 | 0.012 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.734301e-01 | 0.012 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.744141e-01 | 0.011 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.746488e-01 | 0.011 | 0 | 0 |
| Aspartate and asparagine metabolism | R-HSA-8963693 | 9.759801e-01 | 0.011 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.772082e-01 | 0.010 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.782854e-01 | 0.010 | 0 | 0 |
| Glyoxylate metabolism and glycine degradation | R-HSA-389661 | 9.784481e-01 | 0.009 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.784481e-01 | 0.009 | 0 | 0 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | R-HSA-2162123 | 9.802267e-01 | 0.009 | 0 | 0 |
| Recycling of bile acids and salts | R-HSA-159418 | 9.803696e-01 | 0.009 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.806980e-01 | 0.008 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 9.812890e-01 | 0.008 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.821027e-01 | 0.008 | 0 | 0 |
| Glutamate and glutamine metabolism | R-HSA-8964539 | 9.822539e-01 | 0.008 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 9.822539e-01 | 0.008 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.826498e-01 | 0.008 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.839574e-01 | 0.007 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 9.839574e-01 | 0.007 | 0 | 0 |
| Metabolism of ingested SeMet, Sec, MeSec into H2Se | R-HSA-2408508 | 9.854975e-01 | 0.006 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.858889e-01 | 0.006 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.859989e-01 | 0.006 | 0 | 0 |
| Sulfur amino acid metabolism | R-HSA-1614635 | 9.859989e-01 | 0.006 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.868898e-01 | 0.006 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 9.868898e-01 | 0.006 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 9.868898e-01 | 0.006 | 0 | 0 |
| Phenylalanine and tyrosine metabolism | R-HSA-8963691 | 9.881485e-01 | 0.005 | 0 | 0 |
| Lysine catabolism | R-HSA-71064 | 9.881485e-01 | 0.005 | 0 | 0 |
| Collagen chain trimerization | R-HSA-8948216 | 9.881485e-01 | 0.005 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 9.888730e-01 | 0.005 | 0 | 0 |
| tRNA processing in the mitochondrion | R-HSA-6785470 | 9.892864e-01 | 0.005 | 0 | 0 |
| alpha-linolenic acid (ALA) metabolism | R-HSA-2046106 | 9.892864e-01 | 0.005 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 9.892864e-01 | 0.005 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 9.909769e-01 | 0.004 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.911348e-01 | 0.004 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 9.912445e-01 | 0.004 | 0 | 0 |
| Maturation of TCA enzymes and regulation of TCA cycle | R-HSA-9854311 | 9.912452e-01 | 0.004 | 0 | 0 |
| rRNA processing in the mitochondrion | R-HSA-8868766 | 9.912452e-01 | 0.004 | 0 | 0 |
| Signaling by Retinoic Acid | R-HSA-5362517 | 9.917380e-01 | 0.004 | 0 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.919205e-01 | 0.004 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.920859e-01 | 0.003 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.928171e-01 | 0.003 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 9.931765e-01 | 0.003 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 9.936635e-01 | 0.003 | 0 | 0 |
| Defensins | R-HSA-1461973 | 9.941542e-01 | 0.003 | 0 | 0 |
| Synthesis of very long-chain fatty acyl-CoAs | R-HSA-75876 | 9.941542e-01 | 0.003 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.942018e-01 | 0.003 | 0 | 0 |
| Methylation | R-HSA-156581 | 9.947157e-01 | 0.002 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 9.947157e-01 | 0.002 | 0 | 0 |
| O-linked glycosylation of mucins | R-HSA-913709 | 9.959410e-01 | 0.002 | 0 | 0 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | R-HSA-2046104 | 9.960971e-01 | 0.002 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.963183e-01 | 0.002 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.964720e-01 | 0.002 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.966068e-01 | 0.001 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.968982e-01 | 0.001 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 9.971174e-01 | 0.001 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.973944e-01 | 0.001 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.974175e-01 | 0.001 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.976325e-01 | 0.001 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.978270e-01 | 0.001 | 0 | 0 |
| Citric acid cycle (TCA cycle) | R-HSA-71403 | 9.978369e-01 | 0.001 | 0 | 0 |
| Glucuronidation | R-HSA-156588 | 9.980758e-01 | 0.001 | 0 | 0 |
| Mitochondrial Fatty Acid Beta-Oxidation | R-HSA-77289 | 9.983082e-01 | 0.001 | 0 | 0 |
| Metabolism of amine-derived hormones | R-HSA-209776 | 9.984279e-01 | 0.001 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 9.984945e-01 | 0.001 | 0 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.985700e-01 | 0.001 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.985791e-01 | 0.001 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.986999e-01 | 0.001 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.987449e-01 | 0.001 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.988391e-01 | 0.001 | 0 | 0 |
| Peroxisomal lipid metabolism | R-HSA-390918 | 9.990453e-01 | 0.000 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.991097e-01 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 9.992124e-01 | 0.000 | 0 | 0 |
| Complex I biogenesis | R-HSA-6799198 | 9.992253e-01 | 0.000 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 9.992745e-01 | 0.000 | 0 | 0 |
| Nicotinate metabolism | R-HSA-196807 | 9.994830e-01 | 0.000 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.994976e-01 | 0.000 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.995255e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.996020e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid catabolism | R-HSA-9840310 | 9.996183e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.996349e-01 | 0.000 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.996550e-01 | 0.000 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.996550e-01 | 0.000 | 0 | 0 |
| Aspirin ADME | R-HSA-9749641 | 9.997182e-01 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 9.997291e-01 | 0.000 | 0 | 0 |
| Transport of vitamins, nucleosides, and related molecules | R-HSA-425397 | 9.997453e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.998007e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.998184e-01 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.998428e-01 | 0.000 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.998465e-01 | 0.000 | 0 | 0 |
| Metabolic disorders of biological oxidation enzymes | R-HSA-5579029 | 9.998465e-01 | 0.000 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.998749e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.998786e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.999350e-01 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 9.999553e-01 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 9.999589e-01 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 9.999694e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 9.999782e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.999800e-01 | 0.000 | 0 | 0 |
| Sensory perception of sweet, bitter, and umami (glutamate) taste | R-HSA-9717207 | 9.999856e-01 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 9.999875e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.999876e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999907e-01 | 0.000 | 0 | 0 |
| Sensory perception of taste | R-HSA-9717189 | 9.999944e-01 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 9.999948e-01 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 9.999948e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.999971e-01 | 0.000 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.999982e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid metabolism | R-HSA-1660662 | 9.999990e-01 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 9.999992e-01 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 9.999994e-01 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 9.999996e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.999996e-01 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 9.999997e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999997e-01 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 9.999999e-01 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | 0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 1 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
