BMPR1A

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A6ND36 S610 SIGNOR FAM83G PAWS1 LSDQDSHSGSSGRGPGPRRPsVAssVsEEyFEVREHSVPLR
A6ND36 S614 SIGNOR FAM83G PAWS1 DSHSGSSGRGPGPRRPsVAssVsEEyFEVREHSVPLRRRHs
A6ND36 S616 SIGNOR FAM83G PAWS1 HSGSSGRGPGPRRPsVAssVsEEyFEVREHSVPLRRRHsEQ
O00170 T48 Sugiyama AIP XAP2 FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O60231 S107 Sugiyama DHX16 DBP2 DDX16 KIAA0577 PRP2 ARALLEKNRSYRLLEDsEEssEEtVsRAGsSLQKKRKKRKH
O95394 T62 Sugiyama PGM3 AGM1 MGLLAVLRSKQTKSTIGVMVtAsHNPEEDNGVKLVDPLGEM
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05388 S307 Sugiyama RPLP0 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P07195 T18 Sugiyama LDHB ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07900 S263 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P12956 S560 Sugiyama XRCC6 G22P1 VtKRKHDNEGSGSKRPKVEysEEELKTHISKGTLGKFTVPM
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P18669 S14 Sugiyama PGAM1 PGAMA CDABP0006 _______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P27348 S37 Sugiyama YWHAQ ERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKNVVGGRRS
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P31947 S37 Sugiyama SFN HME1 ERyEDMAAFMKGAVEKGEELsCEERNLLsVAyKNVVGGQRA
P35579 S1943 Sugiyama MYH9 RGDLPFVVPRRMARKGAGDGsDEEVDGKADGAEAKPAE___
P36894 S205 Sugiyama BMPR1A ACVRLK3 ALK3 SRRRYNRDLEQDEAFIPVGEsLKDLIDQsQssGsGSGLPLL
P36894 S213 Sugiyama BMPR1A ACVRLK3 ALK3 LEQDEAFIPVGEsLKDLIDQsQssGsGSGLPLLVQRTIAKQ
P36894 S215 Sugiyama BMPR1A ACVRLK3 ALK3 QDEAFIPVGEsLKDLIDQsQssGsGSGLPLLVQRTIAKQIQ
P36894 S216 Sugiyama BMPR1A ACVRLK3 ALK3 DEAFIPVGEsLKDLIDQsQssGsGSGLPLLVQRTIAKQIQM
P36894 S218 Sugiyama BMPR1A ACVRLK3 ALK3 AFIPVGEsLKDLIDQsQssGsGSGLPLLVQRTIAKQIQMVR
P36894 S416 Sugiyama BMPR1A ACVRLK3 ALK3 VPLNTRVGTKRYMAPEVLDEsLNKNHFQPYIMADIYSFGLI
P36894 T391 Sugiyama BMPR1A ACVRLK3 ALK3 KKNGSCCIADLGLAVKFNSDtNEVDVPLNTRVGTKRYMAPE
P49327 S2198 Sugiyama FASN FAS EVRQLTLRKLQELSSKADEAsELACPtPKEDGLAQQQtQLN
P54578 S492 Sugiyama USP14 TGT WHIAYVLLYGPRRVEIMEEEsEQ__________________
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S263 Sugiyama RPS3A FTE1 MFTL GDEtGAKVERADGyEPPVQEsV___________________
P63104 S37 Sugiyama YWHAZ ERyDDMAACMKsVtEQGAELsNEERNLLsVAyKNVVGARRs
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13873 S375 Sugiyama BMPR2 PPH1 SMRLTGNRLVRPGEEDNAAIsEVGtIRYMAPEVLEGAVNLR
Q13873 S680 Sugiyama BMPR2 PPH1 EEDLETNKLDPKEVDKNLKEssDENLMEHsLKQFSGPDPLS
Q13873 S689 Sugiyama BMPR2 PPH1 DPKEVDKNLKEssDENLMEHsLKQFSGPDPLSSTSSSLLyP
Q13873 T803 Sugiyama BMPR2 PPH1 QVETGVAKMNtINAAEPHVVtVtMNGVAGRNHSVNsHAATt
Q13873 T805 Sugiyama BMPR2 PPH1 ETGVAKMNtINAAEPHVVtVtMNGVAGRNHSVNsHAATtQY
Q14152 S1256 Sugiyama EIF3A EIF3S10 KIAA0139 EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15797 S463 SIGNOR SMAD1 BSP1 MADH1 MADR1 PLQWLDKVLTQMGsPHNPIssVs__________________
Q15797 S465 SIGNOR SMAD1 BSP1 MADH1 MADR1 QWLDKVLTQMGsPHNPIssVs____________________
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q6PCE3 S175 Sugiyama PGM2L1 BM32A PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8IWX8 S822 Sugiyama CHERP DAN26 SCAF6 SKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRLGEE
Q8NHW5 S307 Sugiyama RPLP0P6 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q92769 S422 Sugiyama HDAC2 PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q99497 S57 Sugiyama PARK7 GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.907371e-09 8.536 0 0
Metabolism of RNA R-HSA-8953854 5.819300e-08 7.235 0 0
Chromatin organization R-HSA-4839726 8.450283e-07 6.073 0 0
Chromatin modifying enzymes R-HSA-3247509 6.517208e-07 6.186 0 0
mRNA Splicing - Major Pathway R-HSA-72163 8.588576e-06 5.066 0 0
mRNA Splicing R-HSA-72172 7.911397e-06 5.102 0 0
Signaling by Hippo R-HSA-2028269 2.269715e-05 4.644 0 0
Apoptotic execution phase R-HSA-75153 3.071974e-05 4.513 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.487389e-05 4.457 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.661191e-05 4.062 0 0
DNA Repair R-HSA-73894 9.717016e-05 4.012 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.880335e-04 3.726 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.297741e-04 3.639 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.895074e-04 3.538 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.778769e-04 3.423 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.811742e-04 3.419 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.688429e-04 3.245 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.641244e-04 3.249 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.235052e-04 3.141 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.824822e-04 3.166 0 0
Cell Cycle R-HSA-1640170 7.241620e-04 3.140 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.398769e-04 3.076 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 8.328988e-04 3.079 0 0
mRNA 3'-end processing R-HSA-72187 1.249455e-03 2.903 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.249455e-03 2.903 0 0
Nucleotide Excision Repair R-HSA-5696398 1.278226e-03 2.893 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.281768e-03 2.892 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.409608e-03 2.851 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.999720e-03 2.699 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.186915e-03 2.660 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.422341e-03 2.616 0 0
snRNP Assembly R-HSA-191859 2.756264e-03 2.560 0 0
Metabolism of non-coding RNA R-HSA-194441 2.756264e-03 2.560 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.057233e-03 2.515 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.117679e-03 2.506 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.383824e-03 2.471 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.534136e-03 2.452 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 3.801636e-03 2.420 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.225920e-03 2.374 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.225920e-03 2.374 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.367053e-03 2.360 0 0
MTOR signalling R-HSA-165159 4.716693e-03 2.326 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.836465e-03 2.315 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.680394e-03 2.246 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.680394e-03 2.246 0 0
rRNA processing R-HSA-72312 6.368191e-03 2.196 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.598443e-03 2.181 0 0
Ephrin signaling R-HSA-3928664 7.041794e-03 2.152 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.735166e-03 2.112 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 8.360857e-03 2.078 0 0
HIV Life Cycle R-HSA-162587 9.997815e-03 2.000 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.068817e-02 1.971 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.195317e-02 1.923 0 0
Regulation of TP53 Activity R-HSA-5633007 1.163678e-02 1.934 0 0
Cell Cycle, Mitotic R-HSA-69278 1.300923e-02 1.886 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.819772e-02 1.740 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.819772e-02 1.740 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.819772e-02 1.740 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.819772e-02 1.740 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.819772e-02 1.740 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.819772e-02 1.740 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.819772e-02 1.740 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.819772e-02 1.740 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.819772e-02 1.740 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.819772e-02 1.740 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.819772e-02 1.740 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.434967e-02 1.843 0 0
Notch-HLH transcription pathway R-HSA-350054 1.534842e-02 1.814 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.610454e-02 1.793 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.798100e-02 1.745 0 0
G0 and Early G1 R-HSA-1538133 1.436784e-02 1.843 0 0
HDACs deacetylate histones R-HSA-3214815 1.706704e-02 1.768 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.610454e-02 1.793 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.756264e-02 1.755 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.751168e-02 1.757 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.021971e-02 1.694 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.911627e-02 1.719 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.053693e-02 1.687 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.247362e-02 1.648 0 0
Dual incision in TC-NER R-HSA-6782135 2.176513e-02 1.662 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.175785e-02 1.662 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.205267e-02 1.657 0 0
Ub-specific processing proteases R-HSA-5689880 2.226563e-02 1.652 0 0
HDMs demethylate histones R-HSA-3214842 2.260183e-02 1.646 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.432129e-02 1.614 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.363389e-02 1.626 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.351620e-02 1.629 0 0
Gene expression (Transcription) R-HSA-74160 2.451908e-02 1.610 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.543866e-02 1.595 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.750277e-02 1.561 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.750277e-02 1.561 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.697561e-02 1.569 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.750277e-02 1.561 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.822325e-02 1.549 0 0
Deubiquitination R-HSA-5688426 2.841666e-02 1.546 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.961684e-02 1.528 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.145436e-02 1.502 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 3.831266e-02 1.417 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 3.831266e-02 1.417 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.587822e-02 1.445 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.901014e-02 1.409 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.793993e-02 1.421 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.793993e-02 1.421 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.901014e-02 1.409 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.853708e-02 1.414 0 0
Bicarbonate transporters R-HSA-425381 3.587822e-02 1.445 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.539474e-02 1.451 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.539474e-02 1.451 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.370443e-02 1.472 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.926933e-02 1.406 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.944977e-02 1.404 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.062401e-02 1.391 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.062401e-02 1.391 0 0
DNA Double Strand Break Response R-HSA-5693606 4.118651e-02 1.385 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 4.976692e-02 1.303 0 0
PDGFR mutants bind TKIs R-HSA-9674428 4.976692e-02 1.303 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 4.976692e-02 1.303 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 4.976692e-02 1.303 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 4.976692e-02 1.303 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 4.976692e-02 1.303 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.045493e-02 1.297 0 0
NF-kB is activated and signals survival R-HSA-209560 4.253947e-02 1.371 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.977331e-02 1.303 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.297597e-02 1.367 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.297597e-02 1.367 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.737832e-02 1.324 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.253947e-02 1.371 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.045493e-02 1.297 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.534025e-02 1.344 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.571900e-02 1.340 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.563932e-02 1.341 0 0
Apoptosis R-HSA-109581 4.692347e-02 1.329 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.045493e-02 1.297 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.115349e-02 1.291 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.756370e-02 1.240 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.756370e-02 1.240 0 0
mTORC1-mediated signalling R-HSA-166208 5.692538e-02 1.245 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.692538e-02 1.245 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.160984e-02 1.287 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.627949e-02 1.250 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.265754e-02 1.279 0 0
TCR signaling R-HSA-202403 5.206657e-02 1.283 0 0
HIV Infection R-HSA-162906 5.403450e-02 1.267 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.160984e-02 1.287 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.627949e-02 1.250 0 0
Cell Cycle Checkpoints R-HSA-69620 5.203390e-02 1.284 0 0
RMTs methylate histone arginines R-HSA-3214858 5.284633e-02 1.277 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 9.705995e-02 1.013 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 9.705995e-02 1.013 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 9.705995e-02 1.013 0 0
Diseases of Telomere Maintenance R-HSA-9673013 9.705995e-02 1.013 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 9.705995e-02 1.013 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 9.705995e-02 1.013 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 9.705995e-02 1.013 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 1.420019e-01 0.848 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 1.420019e-01 0.848 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 1.420019e-01 0.848 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.420019e-01 0.848 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.420019e-01 0.848 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.847096e-01 0.734 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.847096e-01 0.734 0 0
CREB phosphorylation R-HSA-199920 7.811291e-02 1.107 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 9.334716e-02 1.030 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 9.334716e-02 1.030 0 0
Recycling of eIF2:GDP R-HSA-72731 9.334716e-02 1.030 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.334716e-02 1.030 0 0
PLC-gamma1 signalling R-HSA-167021 2.252939e-01 0.647 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 2.252939e-01 0.647 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 2.252939e-01 0.647 0 0
Defective ABCC2 causes DJS R-HSA-5679001 2.252939e-01 0.647 0 0
Defective ABCD4 causes MAHCJ R-HSA-5683329 2.252939e-01 0.647 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.093492e-01 0.961 0 0
WNT mediated activation of DVL R-HSA-201688 1.260052e-01 0.900 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 2.638603e-01 0.579 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.638603e-01 0.579 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.473717e-02 1.126 0 0
2-LTR circle formation R-HSA-164843 1.432105e-01 0.844 0 0
IRS activation R-HSA-74713 3.005090e-01 0.522 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.005090e-01 0.522 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.303131e-02 1.200 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.303131e-02 1.200 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.788944e-01 0.747 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.258765e-01 0.900 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.972053e-01 0.705 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.972053e-01 0.705 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.353353e-01 0.475 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.353353e-01 0.475 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.353353e-01 0.475 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.068962e-02 1.042 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.068962e-02 1.042 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.632362e-02 1.178 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.837781e-02 1.007 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.837781e-02 1.007 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.837781e-02 1.007 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.837781e-02 1.007 0 0
HIV elongation arrest and recovery R-HSA-167287 9.837781e-02 1.007 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.837781e-02 1.007 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.169609e-02 1.145 0 0
Activation of the pre-replicative complex R-HSA-68962 1.146218e-01 0.941 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.684296e-01 0.434 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.684296e-01 0.434 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 3.684296e-01 0.434 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 3.684296e-01 0.434 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.684296e-01 0.434 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 3.684296e-01 0.434 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.547239e-02 1.020 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.531562e-01 0.597 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.531562e-01 0.597 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.531562e-01 0.597 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.531562e-01 0.597 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.531562e-01 0.597 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.989624e-01 0.701 0 0
Deadenylation of mRNA R-HSA-429947 1.989624e-01 0.701 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.719442e-01 0.566 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 3.998781e-01 0.398 0 0
SOS-mediated signalling R-HSA-112412 3.998781e-01 0.398 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.543832e-02 1.020 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.127756e-01 0.948 0 0
RUNX2 regulates bone development R-HSA-8941326 1.794527e-01 0.746 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.452945e-01 0.838 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.386136e-01 0.622 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.386136e-01 0.622 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.094211e-01 0.509 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.297624e-01 0.367 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.297624e-01 0.367 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.381749e-01 0.860 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.280252e-01 0.484 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.280252e-01 0.484 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.464903e-01 0.460 0 0
ARMS-mediated activation R-HSA-170984 4.581603e-01 0.339 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.581603e-01 0.339 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.104358e-01 0.957 0 0
Translation initiation complex formation R-HSA-72649 2.128753e-01 0.672 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.647841e-01 0.438 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.647841e-01 0.438 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.647841e-01 0.438 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.647841e-01 0.438 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.851456e-01 0.314 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.851456e-01 0.314 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.498453e-01 0.602 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.498453e-01 0.602 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.084737e-01 0.681 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.084737e-01 0.681 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.007464e-01 0.397 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.007464e-01 0.397 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.785585e-01 0.555 0 0
FGFR2 alternative splicing R-HSA-6803529 4.183672e-01 0.378 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.357207e-01 0.361 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.668572e-01 0.436 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.527898e-01 0.344 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.695598e-01 0.328 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.567093e-01 0.340 0 0
HIV Transcription Initiation R-HSA-167161 4.567093e-01 0.340 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.567093e-01 0.340 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.697746e-01 0.432 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.024501e-01 0.395 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.114206e-01 0.386 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.826551e-01 0.316 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.559880e-01 0.341 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.467103e-01 0.350 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.467103e-01 0.350 0 0
Transcription of the HIV genome R-HSA-167172 1.959334e-01 0.708 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.490709e-01 0.827 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.490709e-01 0.827 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.041400e-01 0.982 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.041400e-01 0.982 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.960681e-02 1.048 0 0
HIV Transcription Elongation R-HSA-167169 9.547239e-02 1.020 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.252348e-01 0.647 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.611465e-01 0.793 0 0
mRNA Capping R-HSA-72086 1.063585e-01 0.973 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.794370e-01 0.554 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.156618e-01 0.666 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.041400e-01 0.982 0 0
Ribosome-associated quality control R-HSA-9948299 2.718944e-01 0.566 0 0
Generation of second messenger molecules R-HSA-202433 9.547239e-02 1.020 0 0
RNA Polymerase III Transcription R-HSA-74158 7.169609e-02 1.145 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.547239e-02 1.020 0 0
Integration of provirus R-HSA-162592 1.788944e-01 0.747 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.794370e-01 0.554 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.870042e-01 0.542 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.790205e-01 0.747 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.851456e-01 0.314 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.077166e-01 0.512 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.675049e-01 0.573 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.005090e-01 0.522 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.169609e-02 1.145 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.919118e-02 1.050 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.209220e-01 0.656 0 0
Regulation of CDH11 function R-HSA-9762292 4.851456e-01 0.314 0 0
PI3K/AKT activation R-HSA-198203 4.851456e-01 0.314 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.554022e-01 0.449 0 0
Eukaryotic Translation Termination R-HSA-72764 4.559880e-01 0.341 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.729986e-02 1.112 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.007464e-01 0.397 0 0
EPH-Ephrin signaling R-HSA-2682334 8.177679e-02 1.087 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.242029e-01 0.649 0 0
Regulation of gap junction activity R-HSA-191650 2.638603e-01 0.579 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.388594e-02 1.027 0 0
Formation of axial mesoderm R-HSA-9796292 2.157292e-01 0.666 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.611465e-01 0.793 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.280252e-01 0.484 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.209220e-01 0.656 0 0
Binding and entry of HIV virion R-HSA-173107 4.851456e-01 0.314 0 0
Separation of Sister Chromatids R-HSA-2467813 2.250409e-01 0.648 0 0
Homology Directed Repair R-HSA-5693538 8.013223e-02 1.096 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.464903e-01 0.460 0 0
Lagging Strand Synthesis R-HSA-69186 3.828779e-01 0.417 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.739890e-01 0.759 0 0
Repression of WNT target genes R-HSA-4641265 1.972053e-01 0.705 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.386136e-01 0.622 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.108798e-01 0.676 0 0
RNA Polymerase I Transcription R-HSA-73864 2.781246e-01 0.556 0 0
Degradation of DVL R-HSA-4641258 3.896941e-01 0.409 0 0
Long-term potentiation R-HSA-9620244 4.695598e-01 0.328 0 0
DAP12 signaling R-HSA-2424491 2.794370e-01 0.554 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.996718e-01 0.700 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.103163e-01 0.677 0 0
Mitochondrial biogenesis R-HSA-1592230 2.304514e-01 0.637 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.919118e-02 1.050 0 0
Mitotic Prometaphase R-HSA-68877 2.911304e-01 0.536 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.119635e-02 1.148 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.589197e-02 1.181 0 0
Formation of the posterior neural plate R-HSA-9832991 1.608695e-01 0.794 0 0
Activation of AKT2 R-HSA-165158 3.005090e-01 0.522 0 0
DNA strand elongation R-HSA-69190 1.319547e-01 0.880 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.719442e-01 0.566 0 0
Killing mechanisms R-HSA-9664420 2.719442e-01 0.566 0 0
PTK6 Expression R-HSA-8849473 3.998781e-01 0.398 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.694746e-01 0.771 0 0
Aggrephagy R-HSA-9646399 2.209220e-01 0.656 0 0
Calcineurin activates NFAT R-HSA-2025928 4.581603e-01 0.339 0 0
Negative regulation of MET activity R-HSA-6807004 3.647841e-01 0.438 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.647841e-01 0.438 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.652408e-01 0.782 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.695598e-01 0.328 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.675628e-01 0.435 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.203778e-01 0.376 0 0
PCP/CE pathway R-HSA-4086400 4.470962e-01 0.350 0 0
Translation R-HSA-72766 3.619368e-01 0.441 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.386212e-01 0.470 0 0
Chromosome Maintenance R-HSA-73886 2.562454e-01 0.591 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.959334e-01 0.708 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.381749e-01 0.860 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.381749e-01 0.860 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.381749e-01 0.860 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.381749e-01 0.860 0 0
Telomere Maintenance R-HSA-157579 4.736053e-01 0.325 0 0
p75NTR signals via NF-kB R-HSA-193639 7.473717e-02 1.126 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.577778e-01 0.802 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.665364e-01 0.331 0 0
Extension of Telomeres R-HSA-180786 4.462245e-01 0.350 0 0
Protein folding R-HSA-391251 4.203778e-01 0.376 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.353353e-01 0.475 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 3.684296e-01 0.434 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 3.684296e-01 0.434 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.735048e-01 0.761 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.190592e-01 0.924 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 4.581603e-01 0.339 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.593355e-01 0.586 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.610179e-01 0.583 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.183672e-01 0.378 0 0
Stabilization of p53 R-HSA-69541 4.168148e-01 0.380 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.302295e-01 0.366 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.975365e-01 0.401 0 0
Signaling by NOTCH3 R-HSA-9012852 4.011170e-01 0.397 0 0
Synthesis of DNA R-HSA-69239 4.057088e-01 0.392 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.861189e-01 0.730 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.252348e-01 0.647 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.190592e-01 0.924 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.665252e-01 0.436 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.077166e-01 0.512 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.380701e-01 0.358 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.260052e-01 0.900 0 0
Circadian clock R-HSA-9909396 3.452959e-01 0.462 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.359176e-01 0.627 0 0
Mitotic Anaphase R-HSA-68882 2.309200e-01 0.637 0 0
Mismatch Repair R-HSA-5358508 1.148124e-01 0.940 0 0
Signaling by EGFR R-HSA-177929 2.311464e-01 0.636 0 0
Heme signaling R-HSA-9707616 2.882759e-01 0.540 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.356123e-01 0.628 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.420019e-01 0.848 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.252939e-01 0.647 0 0
Unwinding of DNA R-HSA-176974 1.260052e-01 0.900 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.638603e-01 0.579 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.638603e-01 0.579 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.473717e-02 1.126 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.432105e-01 0.844 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.005090e-01 0.522 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.946677e-02 1.158 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.788944e-01 0.747 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.972053e-01 0.705 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.353353e-01 0.475 0 0
PDE3B signalling R-HSA-165160 3.353353e-01 0.475 0 0
PKB-mediated events R-HSA-109703 3.353353e-01 0.475 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.157292e-01 0.666 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.531562e-01 0.597 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.659667e-02 1.177 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.999976e-02 1.046 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.989624e-01 0.701 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.375868e-01 0.861 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.094211e-01 0.509 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.297624e-01 0.367 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.280252e-01 0.484 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.657374e-01 0.576 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.303913e-01 0.885 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.794370e-01 0.554 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.464903e-01 0.460 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.581603e-01 0.339 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.290310e-01 0.889 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 4.851456e-01 0.314 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.851456e-01 0.314 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.346650e-01 0.475 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.007464e-01 0.397 0 0
Signaling by NOTCH2 R-HSA-1980145 3.484836e-01 0.458 0 0
Orc1 removal from chromatin R-HSA-68949 3.668572e-01 0.436 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.527898e-01 0.344 0 0
Cellular response to heat stress R-HSA-3371556 9.009674e-02 1.045 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.291656e-01 0.889 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.632362e-02 1.178 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.280252e-01 0.484 0 0
M Phase R-HSA-68886 9.643094e-02 1.016 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.019723e-01 0.992 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.019723e-01 0.992 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.989624e-01 0.701 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.674075e-01 0.776 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.989624e-01 0.701 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.208328e-01 0.494 0 0
S Phase R-HSA-69242 2.328699e-01 0.633 0 0
Signaling by VEGF R-HSA-194138 1.838086e-01 0.736 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.657374e-01 0.576 0 0
MAP kinase activation R-HSA-450294 4.683914e-01 0.329 0 0
ABC transporter disorders R-HSA-5619084 4.470962e-01 0.350 0 0
Signaling by FGFR2 R-HSA-5654738 4.666489e-01 0.331 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.432292e-01 0.614 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.260052e-01 0.900 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.343996e-01 0.630 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.208328e-01 0.494 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.208328e-01 0.494 0 0
ERK/MAPK targets R-HSA-198753 3.828779e-01 0.417 0 0
Signal attenuation R-HSA-74749 4.851456e-01 0.314 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.432292e-01 0.614 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.628369e-01 0.580 0 0
Membrane Trafficking R-HSA-199991 2.732271e-01 0.563 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.628369e-01 0.580 0 0
Autophagy R-HSA-9612973 3.969722e-01 0.401 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.260052e-01 0.900 0 0
Muscarinic acetylcholine receptors R-HSA-390648 3.005090e-01 0.522 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.148124e-01 0.940 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.972053e-01 0.705 0 0
Disorders of Nervous System Development R-HSA-9697154 1.972053e-01 0.705 0 0
Pervasive developmental disorders R-HSA-9005895 1.972053e-01 0.705 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.998781e-01 0.398 0 0
Polo-like kinase mediated events R-HSA-156711 3.280252e-01 0.484 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 1.009152e-01 0.996 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.707730e-01 0.768 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.389126e-01 0.857 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.793536e-01 0.319 0 0
Signaling by FGFR4 R-HSA-5654743 4.826551e-01 0.316 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.432579e-01 0.464 0 0
Post NMDA receptor activation events R-HSA-438064 1.225537e-01 0.912 0 0
Signaling by NOTCH1 R-HSA-1980143 2.610179e-01 0.583 0 0
Gastrulation R-HSA-9758941 2.385202e-01 0.622 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.426698e-01 0.846 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.763902e-01 0.754 0 0
Smooth Muscle Contraction R-HSA-445355 9.543832e-02 1.020 0 0
G2/M Checkpoints R-HSA-69481 6.452875e-02 1.190 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.581603e-01 0.339 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.695598e-01 0.328 0 0
Macroautophagy R-HSA-1632852 2.909353e-01 0.536 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.763902e-01 0.754 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.491711e-01 0.826 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.915025e-01 0.718 0 0
Adherens junctions interactions R-HSA-418990 1.649757e-01 0.783 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.201415e-01 0.920 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.201415e-01 0.920 0 0
Kinesins R-HSA-983189 1.381749e-01 0.860 0 0
Diseases of Immune System R-HSA-5260271 2.209220e-01 0.656 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.209220e-01 0.656 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.798168e-01 0.745 0 0
TBC/RABGAPs R-HSA-8854214 4.826551e-01 0.316 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.657374e-01 0.576 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.242029e-01 0.649 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.357207e-01 0.361 0 0
Cell-cell junction organization R-HSA-421270 3.133067e-01 0.504 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.174992e-01 0.930 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.160009e-01 0.936 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.252939e-01 0.647 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.260052e-01 0.900 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.684296e-01 0.434 0 0
VLDL clearance R-HSA-8964046 3.998781e-01 0.398 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.998781e-01 0.398 0 0
Disorders of Developmental Biology R-HSA-9675151 2.907141e-01 0.537 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.832223e-02 1.054 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.297624e-01 0.367 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.381749e-01 0.860 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.280252e-01 0.484 0 0
Specification of the neural plate border R-HSA-9834899 3.464903e-01 0.460 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.581603e-01 0.339 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.851456e-01 0.314 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.396696e-01 0.469 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.728044e-01 0.429 0 0
Selective autophagy R-HSA-9663891 3.755035e-01 0.425 0 0
Cell junction organization R-HSA-446728 3.556304e-01 0.449 0 0
RNA Polymerase II Transcription R-HSA-73857 1.556392e-01 0.808 0 0
Neurexins and neuroligins R-HSA-6794361 3.668572e-01 0.436 0 0
Protein ubiquitination R-HSA-8852135 6.600043e-02 1.180 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.432105e-01 0.844 0 0
Formation of definitive endoderm R-HSA-9823730 1.373051e-01 0.862 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.188869e-01 0.925 0 0
Pexophagy R-HSA-9664873 4.851456e-01 0.314 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.435312e-01 0.353 0 0
Axon guidance R-HSA-422475 3.029253e-01 0.519 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.730205e-01 0.564 0 0
Nervous system development R-HSA-9675108 2.424365e-01 0.615 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.775597e-01 0.423 0 0
G1/S Transition R-HSA-69206 1.838086e-01 0.736 0 0
DNA Damage Bypass R-HSA-73893 3.324978e-01 0.478 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.975365e-01 0.401 0 0
Cell-Cell communication R-HSA-1500931 3.580566e-01 0.446 0 0
Interleukin-1 signaling R-HSA-9020702 3.482170e-01 0.458 0 0
Nuclear import of Rev protein R-HSA-180746 6.118432e-02 1.213 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.684296e-01 0.434 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.007464e-01 0.397 0 0
Recycling pathway of L1 R-HSA-437239 3.096695e-01 0.509 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.567093e-01 0.340 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.621697e-01 0.441 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.679615e-01 0.775 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.837569e-01 0.315 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.077166e-01 0.512 0 0
Developmental Cell Lineages R-HSA-9734767 4.771534e-01 0.321 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.689092e-01 0.570 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.302295e-01 0.366 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.007464e-01 0.397 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.793536e-01 0.319 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.978770e-01 0.704 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.978770e-01 0.704 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.978770e-01 0.704 0 0
MECP2 regulates transcription factors R-HSA-9022707 9.334716e-02 1.030 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.353353e-01 0.475 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.019723e-01 0.992 0 0
Regulation of PTEN localization R-HSA-8948747 3.998781e-01 0.398 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.998781e-01 0.398 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.297624e-01 0.367 0 0
Sodium/Proton exchangers R-HSA-425986 4.297624e-01 0.367 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.581603e-01 0.339 0 0
Trafficking of AMPA receptors R-HSA-399719 2.931997e-01 0.533 0 0
TGFBR3 expression R-HSA-9839394 4.695598e-01 0.328 0 0
Host Interactions of HIV factors R-HSA-162909 2.761743e-01 0.559 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.802319e-01 0.552 0 0
Mitotic Prophase R-HSA-68875 1.528042e-01 0.816 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.096695e-01 0.509 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.791484e-01 0.320 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.024501e-01 0.395 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.855101e-01 0.414 0 0
Interleukin-7 signaling R-HSA-1266695 7.622618e-02 1.118 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.252348e-01 0.647 0 0
FLT3 signaling in disease R-HSA-9682385 3.760136e-01 0.425 0 0
Amino acid transport across the plasma membrane R-HSA-352230 2.593355e-01 0.586 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.319547e-01 0.880 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.410019e-01 0.851 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.094211e-01 0.509 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.346650e-01 0.475 0 0
SLC-mediated transport of amino acids R-HSA-9958863 3.376171e-01 0.472 0 0
Signaling by ERBB2 R-HSA-1227986 4.573462e-01 0.340 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.794370e-01 0.554 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 2.056856e-01 0.687 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.095468e-01 0.509 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.319374e-01 0.479 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.215991e-01 0.654 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 8.837462e-02 1.054 0 0
Signaling by FGFR in disease R-HSA-1226099 4.075040e-01 0.390 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 9.334716e-02 1.030 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.093492e-01 0.961 0 0
Interleukin-1 processing R-HSA-448706 1.260052e-01 0.900 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.473717e-02 1.126 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.353353e-01 0.475 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.353353e-01 0.475 0 0
Signal regulatory protein family interactions R-HSA-391160 2.343996e-01 0.630 0 0
HDL clearance R-HSA-8964011 3.684296e-01 0.434 0 0
Nef and signal transduction R-HSA-164944 3.684296e-01 0.434 0 0
Formation of the anterior neural plate R-HSA-9823739 2.531562e-01 0.597 0 0
CHL1 interactions R-HSA-447041 3.998781e-01 0.398 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.452945e-01 0.838 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.581603e-01 0.339 0 0
Lipophagy R-HSA-9613354 4.581603e-01 0.339 0 0
Basigin interactions R-HSA-210991 3.828779e-01 0.417 0 0
L1CAM interactions R-HSA-373760 2.241578e-01 0.649 0 0
Death Receptor Signaling R-HSA-73887 1.076425e-01 0.968 0 0
Disorders of transmembrane transporters R-HSA-5619115 3.900166e-01 0.409 0 0
Signaling by ALK in cancer R-HSA-9700206 8.837462e-02 1.054 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.148124e-01 0.940 0 0
G1/S-Specific Transcription R-HSA-69205 1.794527e-01 0.746 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 7.726278e-02 1.112 0 0
Programmed Cell Death R-HSA-5357801 1.192360e-01 0.924 0 0
Inositol phosphate metabolism R-HSA-1483249 1.878723e-01 0.726 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.919118e-02 1.050 0 0
Adrenoceptors R-HSA-390696 4.297624e-01 0.367 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.280252e-01 0.484 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.581603e-01 0.339 0 0
Josephin domain DUBs R-HSA-5689877 4.851456e-01 0.314 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.892852e-01 0.410 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.914945e-01 0.535 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.157505e-01 0.501 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.300662e-01 0.886 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.611465e-01 0.793 0 0
Signaling by ROBO receptors R-HSA-376176 4.606102e-01 0.337 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.093492e-01 0.961 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.684296e-01 0.434 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 1.998610e-01 0.699 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.647841e-01 0.438 0 0
tRNA processing in the nucleus R-HSA-6784531 2.882759e-01 0.540 0 0
PTEN Regulation R-HSA-6807070 4.022950e-01 0.395 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.124719e-01 0.385 0 0
Influenza Infection R-HSA-168255 3.148397e-01 0.502 0 0
Syndecan interactions R-HSA-3000170 4.357207e-01 0.361 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.425332e-01 0.615 0 0
Signaling by TGFB family members R-HSA-9006936 4.240170e-01 0.373 1 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.309247e-01 0.366 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.581603e-01 0.339 0 0
Gene Silencing by RNA R-HSA-211000 4.057088e-01 0.392 0 0
Semaphorin interactions R-HSA-373755 2.980535e-01 0.526 0 0
Signaling by ALK R-HSA-201556 2.103163e-01 0.677 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.208328e-01 0.494 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.258765e-01 0.900 0 0
Specification of primordial germ cells R-HSA-9827857 3.094211e-01 0.509 0 0
Signaling by Leptin R-HSA-2586552 4.851456e-01 0.314 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.297624e-01 0.367 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.668572e-01 0.436 0 0
SLC transporter disorders R-HSA-5619102 4.711626e-01 0.327 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.531562e-01 0.597 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.208328e-01 0.494 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 1.972053e-01 0.705 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.695598e-01 0.328 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.851456e-01 0.314 0 0
DNA Damage Reversal R-HSA-73942 2.531562e-01 0.597 0 0
The NLRP3 inflammasome R-HSA-844456 3.464903e-01 0.460 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 4.573462e-01 0.340 0 0
MET activates PTK2 signaling R-HSA-8874081 4.860182e-01 0.313 0 0
Myogenesis R-HSA-525793 4.860182e-01 0.313 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.860182e-01 0.313 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.860182e-01 0.313 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.860182e-01 0.313 0 0
Potential therapeutics for SARS R-HSA-9679191 4.877059e-01 0.312 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.954052e-01 0.305 0 0
Netrin-1 signaling R-HSA-373752 4.954052e-01 0.305 0 0
DAP12 interactions R-HSA-2172127 4.954052e-01 0.305 0 0
Interferon Signaling R-HSA-913531 4.967492e-01 0.304 0 0
ABC-family proteins mediated transport R-HSA-382556 4.997124e-01 0.301 0 0
Glycolysis R-HSA-70171 4.997124e-01 0.301 0 0
Ion transport by P-type ATPases R-HSA-936837 5.010051e-01 0.300 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.021545e-01 0.299 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.021545e-01 0.299 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.021545e-01 0.299 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.021545e-01 0.299 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.050699e-01 0.297 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.079962e-01 0.294 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.079962e-01 0.294 0 0
Nucleosome assembly R-HSA-774815 5.079962e-01 0.294 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.079962e-01 0.294 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.079962e-01 0.294 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.079962e-01 0.294 0 0
Somitogenesis R-HSA-9824272 5.079962e-01 0.294 0 0
Signaling by FGFR3 R-HSA-5654741 5.079962e-01 0.294 0 0
DAG and IP3 signaling R-HSA-1489509 5.079962e-01 0.294 0 0
DNA Replication R-HSA-69306 5.086607e-01 0.294 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.107885e-01 0.292 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.107885e-01 0.292 0 0
Synthesis of PI R-HSA-1483226 5.107885e-01 0.292 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.107885e-01 0.292 0 0
PECAM1 interactions R-HSA-210990 5.107885e-01 0.292 0 0
Suppression of apoptosis R-HSA-9635465 5.107885e-01 0.292 0 0
Transport of RCbl within the body R-HSA-9758890 5.107885e-01 0.292 0 0
Prostanoid ligand receptors R-HSA-391908 5.107885e-01 0.292 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.116830e-01 0.291 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.116830e-01 0.291 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.145068e-01 0.289 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.179600e-01 0.286 0 0
Telomere Extension By Telomerase R-HSA-171319 5.179600e-01 0.286 0 0
Inflammasomes R-HSA-622312 5.179600e-01 0.286 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.204209e-01 0.284 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.204209e-01 0.284 0 0
Diseases of DNA repair R-HSA-9675135 5.204209e-01 0.284 0 0
Signaling by TGFBR3 R-HSA-9839373 5.204209e-01 0.284 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.207840e-01 0.283 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.326731e-01 0.274 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.326731e-01 0.274 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.331509e-01 0.273 0 0
Late endosomal microautophagy R-HSA-9615710 5.334275e-01 0.273 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.334275e-01 0.273 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.334275e-01 0.273 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.334275e-01 0.273 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.337862e-01 0.273 0 0
DS-GAG biosynthesis R-HSA-2022923 5.351557e-01 0.272 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.351557e-01 0.272 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.351557e-01 0.272 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.351557e-01 0.272 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 5.351557e-01 0.272 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.351557e-01 0.272 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.351557e-01 0.272 0 0
ERKs are inactivated R-HSA-202670 5.351557e-01 0.272 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.351557e-01 0.272 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.351557e-01 0.272 0 0
Activation of RAC1 R-HSA-428540 5.351557e-01 0.272 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 5.351557e-01 0.272 0 0
HCMV Early Events R-HSA-9609690 5.379050e-01 0.269 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.421883e-01 0.266 0 0
Intraflagellar transport R-HSA-5620924 5.447468e-01 0.264 0 0
Co-stimulation by CD28 R-HSA-389356 5.447468e-01 0.264 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.459264e-01 0.263 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.485515e-01 0.261 0 0
MHC class II antigen presentation R-HSA-2132295 5.499316e-01 0.260 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.508222e-01 0.259 0 0
Peptide chain elongation R-HSA-156902 5.514650e-01 0.258 0 0
SARS-CoV Infections R-HSA-9679506 5.560790e-01 0.255 0 0
Degradation of CDH1 R-HSA-9766229 5.566369e-01 0.254 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.566369e-01 0.254 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.566369e-01 0.254 0 0
Gap junction trafficking and regulation R-HSA-157858 5.566369e-01 0.254 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.583106e-01 0.253 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.583106e-01 0.253 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.583106e-01 0.253 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.583106e-01 0.253 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.583106e-01 0.253 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.583106e-01 0.253 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.583106e-01 0.253 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.583106e-01 0.253 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.583106e-01 0.253 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.583106e-01 0.253 0 0
Signaling by LTK R-HSA-9842663 5.583106e-01 0.253 0 0
Leading Strand Synthesis R-HSA-69109 5.583106e-01 0.253 0 0
Polymerase switching R-HSA-69091 5.583106e-01 0.253 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.583106e-01 0.253 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.583106e-01 0.253 0 0
OAS antiviral response R-HSA-8983711 5.583106e-01 0.253 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.583106e-01 0.253 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.622645e-01 0.250 0 0
Co-inhibition by PD-1 R-HSA-389948 5.622645e-01 0.250 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.633279e-01 0.249 0 0
EGFR downregulation R-HSA-182971 5.633279e-01 0.249 0 0
Downstream signal transduction R-HSA-186763 5.633279e-01 0.249 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.633279e-01 0.249 0 0
Cargo concentration in the ER R-HSA-5694530 5.633279e-01 0.249 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.633983e-01 0.249 0 0
Interleukin-17 signaling R-HSA-448424 5.633983e-01 0.249 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.633983e-01 0.249 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.683389e-01 0.245 0 0
Downstream TCR signaling R-HSA-202424 5.694235e-01 0.245 0 0
Base Excision Repair R-HSA-73884 5.694235e-01 0.245 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.770155e-01 0.239 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.777538e-01 0.238 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.777538e-01 0.238 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.803134e-01 0.236 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.803134e-01 0.236 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.803134e-01 0.236 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.803134e-01 0.236 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.803134e-01 0.236 0 0
Maturation of nucleoprotein R-HSA-9683610 5.803134e-01 0.236 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.803134e-01 0.236 0 0
Interleukin-6 signaling R-HSA-1059683 5.803134e-01 0.236 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.803134e-01 0.236 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.829462e-01 0.234 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.832269e-01 0.234 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.832269e-01 0.234 0 0
IRE1alpha activates chaperones R-HSA-381070 5.870039e-01 0.231 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.918274e-01 0.228 0 0
Integrin signaling R-HSA-354192 5.918274e-01 0.228 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.918274e-01 0.228 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.918274e-01 0.228 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.918274e-01 0.228 0 0
G-protein beta:gamma signalling R-HSA-397795 5.918274e-01 0.228 0 0
Nuclear RNA decay R-HSA-9930044 5.918274e-01 0.228 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.918274e-01 0.228 0 0
Removal of the Flap Intermediate R-HSA-69166 6.012214e-01 0.221 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.012214e-01 0.221 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.012214e-01 0.221 0 0
cGMP effects R-HSA-418457 6.012214e-01 0.221 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.012214e-01 0.221 0 0
Regulation of KIT signaling R-HSA-1433559 6.012214e-01 0.221 0 0
Zinc transporters R-HSA-435354 6.012214e-01 0.221 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.012214e-01 0.221 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.022784e-01 0.220 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.041864e-01 0.219 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.055480e-01 0.218 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.055480e-01 0.218 0 0
Heme degradation R-HSA-189483 6.055480e-01 0.218 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.131927e-01 0.212 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.189159e-01 0.208 0 0
Dual Incision in GG-NER R-HSA-5696400 6.189159e-01 0.208 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.189159e-01 0.208 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.189159e-01 0.208 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.189159e-01 0.208 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.189159e-01 0.208 0 0
Gap junction assembly R-HSA-190861 6.189159e-01 0.208 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.189159e-01 0.208 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.209539e-01 0.207 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.210890e-01 0.207 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.210890e-01 0.207 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.210890e-01 0.207 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.210890e-01 0.207 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.210890e-01 0.207 0 0
DCC mediated attractive signaling R-HSA-418885 6.210890e-01 0.207 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.210890e-01 0.207 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.210890e-01 0.207 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.210890e-01 0.207 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.210890e-01 0.207 0 0
Protein methylation R-HSA-8876725 6.210890e-01 0.207 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.210890e-01 0.207 0 0
Interleukin-12 signaling R-HSA-9020591 6.212738e-01 0.207 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.239038e-01 0.205 0 0
Toll-like Receptor Cascades R-HSA-168898 6.296037e-01 0.201 0 0
Regulation of Apoptosis R-HSA-169911 6.319322e-01 0.199 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.319322e-01 0.199 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.334707e-01 0.198 0 0
Signaling by FGFR1 R-HSA-5654736 6.344101e-01 0.198 0 0
NRAGE signals death through JNK R-HSA-193648 6.344101e-01 0.198 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.381717e-01 0.195 0 0
Phosphorylation of the APC/C R-HSA-176412 6.399680e-01 0.194 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.399680e-01 0.194 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.399680e-01 0.194 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.399680e-01 0.194 0 0
Prolonged ERK activation events R-HSA-169893 6.399680e-01 0.194 0 0
Negative regulation of FLT3 R-HSA-9706369 6.399680e-01 0.194 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.399680e-01 0.194 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.399680e-01 0.194 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.399680e-01 0.194 0 0
Atorvastatin ADME R-HSA-9754706 6.399680e-01 0.194 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.445986e-01 0.191 0 0
HSF1 activation R-HSA-3371511 6.445986e-01 0.191 0 0
Calmodulin induced events R-HSA-111933 6.445986e-01 0.191 0 0
CaM pathway R-HSA-111997 6.445986e-01 0.191 0 0
GPVI-mediated activation cascade R-HSA-114604 6.445986e-01 0.191 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.445986e-01 0.191 0 0
Regulation of CDH1 Function R-HSA-9764561 6.447102e-01 0.191 0 0
Signaling by FGFR R-HSA-190236 6.531889e-01 0.185 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.548034e-01 0.184 0 0
Signaling by WNT R-HSA-195721 6.558128e-01 0.183 0 0
Degradation of AXIN R-HSA-4641257 6.569178e-01 0.182 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.569178e-01 0.182 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.570581e-01 0.182 0 0
Signaling by MET R-HSA-6806834 6.570581e-01 0.182 0 0
PKR-mediated signaling R-HSA-9833482 6.570581e-01 0.182 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 6.579074e-01 0.182 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 6.579074e-01 0.182 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.579074e-01 0.182 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.579074e-01 0.182 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.579074e-01 0.182 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.579074e-01 0.182 0 0
Synthesis of PG R-HSA-1483148 6.579074e-01 0.182 0 0
Rab regulation of trafficking R-HSA-9007101 6.585157e-01 0.181 0 0
Glucose metabolism R-HSA-70326 6.585157e-01 0.181 0 0
HATs acetylate histones R-HSA-3214847 6.609689e-01 0.180 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.622695e-01 0.179 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.639910e-01 0.178 0 0
Regulation of beta-cell development R-HSA-186712 6.646892e-01 0.177 0 0
MET promotes cell motility R-HSA-8875878 6.688928e-01 0.175 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.688928e-01 0.175 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.749539e-01 0.171 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.749539e-01 0.171 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 6.749539e-01 0.171 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.749539e-01 0.171 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.749539e-01 0.171 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.749539e-01 0.171 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.755274e-01 0.170 0 0
Selenocysteine synthesis R-HSA-2408557 6.761869e-01 0.170 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.805274e-01 0.167 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.805274e-01 0.167 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.823581e-01 0.166 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.838382e-01 0.165 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.838382e-01 0.165 0 0
Viral mRNA Translation R-HSA-192823 6.909441e-01 0.161 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.911521e-01 0.160 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 6.911521e-01 0.160 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.911521e-01 0.160 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 6.911521e-01 0.160 0 0
GAB1 signalosome R-HSA-180292 6.911521e-01 0.160 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.911521e-01 0.160 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.918258e-01 0.160 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.918258e-01 0.160 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.918258e-01 0.160 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.918258e-01 0.160 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 6.918258e-01 0.160 0 0
Signaling by PDGF R-HSA-186797 6.931021e-01 0.159 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.931021e-01 0.159 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.931021e-01 0.159 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.960865e-01 0.157 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.977541e-01 0.156 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.021598e-01 0.154 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.027925e-01 0.153 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.027925e-01 0.153 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.027925e-01 0.153 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.027925e-01 0.153 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.027925e-01 0.153 0 0
FLT3 Signaling R-HSA-9607240 7.027925e-01 0.153 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.052364e-01 0.152 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.052364e-01 0.152 0 0
Viral Infection Pathways R-HSA-9824446 7.062345e-01 0.151 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.063203e-01 0.151 0 0
Regulation of signaling by CBL R-HSA-912631 7.065439e-01 0.151 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.065439e-01 0.151 0 0
Pyrimidine biosynthesis R-HSA-500753 7.065439e-01 0.151 0 0
Rap1 signalling R-HSA-392517 7.065439e-01 0.151 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.065439e-01 0.151 0 0
Translesion Synthesis by POLH R-HSA-110320 7.065439e-01 0.151 0 0
Other interleukin signaling R-HSA-449836 7.065439e-01 0.151 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.065439e-01 0.151 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.065439e-01 0.151 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.065439e-01 0.151 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.065439e-01 0.151 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.065439e-01 0.151 0 0
Maturation of nucleoprotein R-HSA-9694631 7.065439e-01 0.151 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.065439e-01 0.151 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.065439e-01 0.151 0 0
Generic Transcription Pathway R-HSA-212436 7.097293e-01 0.149 0 0
IGF1R signaling cascade R-HSA-2428924 7.110123e-01 0.148 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.110123e-01 0.148 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.134326e-01 0.147 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.134326e-01 0.147 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.134326e-01 0.147 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.134326e-01 0.147 0 0
G2/M Transition R-HSA-69275 7.185980e-01 0.144 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.190614e-01 0.143 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.196609e-01 0.143 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 7.211695e-01 0.142 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.211695e-01 0.142 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.211695e-01 0.142 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.211695e-01 0.142 0 0
Creatine metabolism R-HSA-71288 7.211695e-01 0.142 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.211695e-01 0.142 0 0
Vesicle-mediated transport R-HSA-5653656 7.215226e-01 0.142 0 0
Interleukin-12 family signaling R-HSA-447115 7.215507e-01 0.142 0 0
HCMV Infection R-HSA-9609646 7.232664e-01 0.141 0 0
Ca-dependent events R-HSA-111996 7.237514e-01 0.140 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.257986e-01 0.139 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.289032e-01 0.137 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.289433e-01 0.137 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.337544e-01 0.134 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.337544e-01 0.134 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.350671e-01 0.134 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.350671e-01 0.134 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.350671e-01 0.134 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.350671e-01 0.134 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.350671e-01 0.134 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.350671e-01 0.134 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.350671e-01 0.134 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.350671e-01 0.134 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.363521e-01 0.133 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.371110e-01 0.132 0 0
Surfactant metabolism R-HSA-5683826 7.434474e-01 0.129 0 0
Methylation R-HSA-156581 7.434474e-01 0.129 0 0
Gap junction trafficking R-HSA-190828 7.434474e-01 0.129 0 0
Amine ligand-binding receptors R-HSA-375280 7.434474e-01 0.129 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.443983e-01 0.128 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.454742e-01 0.128 0 0
CS-GAG biosynthesis R-HSA-2022870 7.482728e-01 0.126 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.482728e-01 0.126 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.528366e-01 0.123 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.528366e-01 0.123 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.599021e-01 0.119 0 0
Adipogenesis R-HSA-9843745 7.602348e-01 0.119 0 0
ESR-mediated signaling R-HSA-8939211 7.604849e-01 0.119 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.608210e-01 0.119 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.608210e-01 0.119 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.608210e-01 0.119 0 0
LDL clearance R-HSA-8964038 7.608210e-01 0.119 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.608210e-01 0.119 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.619280e-01 0.118 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.619280e-01 0.118 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.619280e-01 0.118 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.619280e-01 0.118 0 0
Signaling by RAS mutants R-HSA-6802949 7.619280e-01 0.118 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.619280e-01 0.118 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.619280e-01 0.118 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.619280e-01 0.118 0 0
Interleukin-1 family signaling R-HSA-446652 7.637211e-01 0.117 0 0
ECM proteoglycans R-HSA-3000178 7.673641e-01 0.115 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.673641e-01 0.115 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.707281e-01 0.113 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.707281e-01 0.113 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.725447e-01 0.112 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.727444e-01 0.112 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.727444e-01 0.112 0 0
Growth hormone receptor signaling R-HSA-982772 7.727444e-01 0.112 0 0
Signaling by NOTCH R-HSA-157118 7.730882e-01 0.112 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.746361e-01 0.111 0 0
Metal ion SLC transporters R-HSA-425410 7.792433e-01 0.108 0 0
Ca2+ pathway R-HSA-4086398 7.817206e-01 0.107 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.828406e-01 0.106 0 0
Complex III assembly R-HSA-9865881 7.840741e-01 0.106 0 0
Interleukin-6 family signaling R-HSA-6783589 7.840741e-01 0.106 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.874801e-01 0.104 0 0
Chemokine receptors bind chemokines R-HSA-380108 7.874801e-01 0.104 0 0
HCMV Late Events R-HSA-9610379 7.885503e-01 0.103 0 0
Signaling by NOTCH4 R-HSA-9013694 7.886204e-01 0.103 0 0
Signaling by ERBB4 R-HSA-1236394 7.886204e-01 0.103 0 0
Cellular responses to stimuli R-HSA-8953897 7.892271e-01 0.103 0 0
Signal Transduction R-HSA-162582 7.912136e-01 0.102 1 0
Cellular response to starvation R-HSA-9711097 7.932734e-01 0.101 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.938926e-01 0.100 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.948396e-01 0.100 0 0
Laminin interactions R-HSA-3000157 7.948396e-01 0.100 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.948396e-01 0.100 0 0
Formation of the nephric duct R-HSA-9830364 7.948396e-01 0.100 0 0
Hyaluronan degradation R-HSA-2160916 7.948396e-01 0.100 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.948396e-01 0.100 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 7.948396e-01 0.100 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.948396e-01 0.100 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.948986e-01 0.100 0 0
Cellular Senescence R-HSA-2559583 7.953798e-01 0.099 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.954450e-01 0.099 0 0
PI3K Cascade R-HSA-109704 7.954450e-01 0.099 0 0
UCH proteinases R-HSA-5689603 8.018770e-01 0.096 0 0
HSF1-dependent transactivation R-HSA-3371571 8.031448e-01 0.095 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.031448e-01 0.095 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.050690e-01 0.094 0 0
Metalloprotease DUBs R-HSA-5689901 8.050690e-01 0.094 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.050690e-01 0.094 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.050690e-01 0.094 0 0
Sphingolipid catabolism R-HSA-9845614 8.050690e-01 0.094 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.050690e-01 0.094 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.050690e-01 0.094 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.067113e-01 0.093 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.082395e-01 0.092 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.105859e-01 0.091 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.105859e-01 0.091 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.105859e-01 0.091 0 0
FOXO-mediated transcription R-HSA-9614085 8.119689e-01 0.090 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.144288e-01 0.089 0 0
Integrin cell surface interactions R-HSA-216083 8.144288e-01 0.089 0 0
G alpha (12/13) signalling events R-HSA-416482 8.144288e-01 0.089 0 0
Cristae formation R-HSA-8949613 8.147889e-01 0.089 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.147889e-01 0.089 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.147889e-01 0.089 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.147889e-01 0.089 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.147889e-01 0.089 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.177752e-01 0.087 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.177752e-01 0.087 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.226909e-01 0.085 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.240248e-01 0.084 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.240248e-01 0.084 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.247191e-01 0.084 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.314242e-01 0.080 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.328006e-01 0.079 0 0
DNA methylation R-HSA-5334118 8.328006e-01 0.079 0 0
Platelet calcium homeostasis R-HSA-418360 8.328006e-01 0.079 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.328006e-01 0.079 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.328006e-01 0.079 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.328006e-01 0.079 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.328006e-01 0.079 0 0
Signaling by Erythropoietin R-HSA-9006335 8.328006e-01 0.079 0 0
DARPP-32 events R-HSA-180024 8.328006e-01 0.079 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 8.329030e-01 0.079 0 0
Muscle contraction R-HSA-397014 8.363178e-01 0.078 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.378971e-01 0.077 0 0
Ion homeostasis R-HSA-5578775 8.378971e-01 0.077 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.378971e-01 0.077 0 0
TNF signaling R-HSA-75893 8.378971e-01 0.077 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.411322e-01 0.075 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.411322e-01 0.075 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.411322e-01 0.075 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.411392e-01 0.075 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.411392e-01 0.075 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.411392e-01 0.075 0 0
Activation of BH3-only proteins R-HSA-114452 8.411392e-01 0.075 0 0
IRS-mediated signalling R-HSA-112399 8.441443e-01 0.074 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.476372e-01 0.072 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.490625e-01 0.071 0 0
Budding and maturation of HIV virion R-HSA-162588 8.490625e-01 0.071 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.490625e-01 0.071 0 0
Signaling by NTRKs R-HSA-166520 8.497797e-01 0.071 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.501721e-01 0.070 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.531652e-01 0.069 0 0
Peroxisomal protein import R-HSA-9033241 8.559869e-01 0.068 0 0
Developmental Biology R-HSA-1266738 8.560199e-01 0.068 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.565911e-01 0.067 0 0
Signaling by WNT in cancer R-HSA-4791275 8.565911e-01 0.067 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.580816e-01 0.066 0 0
Cellular responses to stress R-HSA-2262752 8.585718e-01 0.066 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.610613e-01 0.065 0 0
tRNA Aminoacylation R-HSA-379724 8.615949e-01 0.065 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.637445e-01 0.064 0 0
Cardiogenesis R-HSA-9733709 8.637445e-01 0.064 0 0
PLC beta mediated events R-HSA-112043 8.670023e-01 0.062 0 0
Cellular response to chemical stress R-HSA-9711123 8.685479e-01 0.061 0 0
Striated Muscle Contraction R-HSA-390522 8.705416e-01 0.060 0 0
CS/DS degradation R-HSA-2024101 8.705416e-01 0.060 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.705416e-01 0.060 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.705416e-01 0.060 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.722151e-01 0.059 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.722151e-01 0.059 0 0
ER-Phagosome pathway R-HSA-1236974 8.763317e-01 0.057 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 8.770000e-01 0.057 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.770000e-01 0.057 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.770000e-01 0.057 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.770000e-01 0.057 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.770000e-01 0.057 0 0
Mitophagy R-HSA-5205647 8.770000e-01 0.057 0 0
RAF activation R-HSA-5673000 8.770000e-01 0.057 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.770000e-01 0.057 0 0
Hyaluronan metabolism R-HSA-2142845 8.770000e-01 0.057 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.770000e-01 0.057 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 8.770000e-01 0.057 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.770000e-01 0.057 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.770000e-01 0.057 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 8.772393e-01 0.057 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 8.772393e-01 0.057 0 0
Signaling by PTK6 R-HSA-8848021 8.772393e-01 0.057 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.772393e-01 0.057 0 0
Post-translational protein modification R-HSA-597592 8.803465e-01 0.055 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.805563e-01 0.055 0 0
Neurotransmitter release cycle R-HSA-112310 8.805563e-01 0.055 0 0
Insulin receptor signalling cascade R-HSA-74751 8.820807e-01 0.054 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.831366e-01 0.054 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.831366e-01 0.054 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.831366e-01 0.054 0 0
Signalling to ERKs R-HSA-187687 8.831366e-01 0.054 0 0
PERK regulates gene expression R-HSA-381042 8.831366e-01 0.054 0 0
Oncogene Induced Senescence R-HSA-2559585 8.831366e-01 0.054 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.831366e-01 0.054 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.831366e-01 0.054 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.831366e-01 0.054 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.889673e-01 0.051 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.889673e-01 0.051 0 0
Glycosphingolipid transport R-HSA-9845576 8.889673e-01 0.051 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.889673e-01 0.051 0 0
RET signaling R-HSA-8853659 8.889673e-01 0.051 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.912379e-01 0.050 0 0
Transmission across Chemical Synapses R-HSA-112315 8.912809e-01 0.050 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.945075e-01 0.048 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.945075e-01 0.048 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.945075e-01 0.048 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.945075e-01 0.048 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.945075e-01 0.048 0 0
G-protein mediated events R-HSA-112040 8.955647e-01 0.048 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.961975e-01 0.048 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.997310e-01 0.046 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.997715e-01 0.046 0 0
Elastic fibre formation R-HSA-1566948 8.997715e-01 0.046 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.998087e-01 0.046 0 0
Leishmania infection R-HSA-9658195 9.003855e-01 0.046 0 0
Parasitic Infection Pathways R-HSA-9824443 9.003855e-01 0.046 0 0
Selenoamino acid metabolism R-HSA-2408522 9.021362e-01 0.045 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.022968e-01 0.045 0 0
Parasite infection R-HSA-9664407 9.022968e-01 0.045 0 0
Leishmania phagocytosis R-HSA-9664417 9.022968e-01 0.045 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.025456e-01 0.045 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.047732e-01 0.043 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.047732e-01 0.043 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.047732e-01 0.043 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 9.047732e-01 0.043 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.051542e-01 0.043 0 0
COPII-mediated vesicle transport R-HSA-204005 9.076025e-01 0.042 0 0
Cilium Assembly R-HSA-5617833 9.081530e-01 0.042 0 0
Attenuation phase R-HSA-3371568 9.095256e-01 0.041 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.095256e-01 0.041 0 0
Neuronal System R-HSA-112316 9.101385e-01 0.041 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.113179e-01 0.040 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.113179e-01 0.040 0 0
Metabolism of porphyrins R-HSA-189445 9.113179e-01 0.040 0 0
Signaling by Interleukins R-HSA-449147 9.120591e-01 0.040 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.132926e-01 0.039 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.140411e-01 0.039 0 0
Maturation of spike protein R-HSA-9694548 9.140411e-01 0.039 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.158667e-01 0.038 0 0
MAP2K and MAPK activation R-HSA-5674135 9.183315e-01 0.037 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.183315e-01 0.037 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.183315e-01 0.037 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.183315e-01 0.037 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.183315e-01 0.037 0 0
Translation of Structural Proteins R-HSA-9683701 9.183315e-01 0.037 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.183323e-01 0.037 0 0
Aspirin ADME R-HSA-9749641 9.183323e-01 0.037 0 0
tRNA processing R-HSA-72306 9.195870e-01 0.036 0 0
Hedgehog 'off' state R-HSA-5610787 9.220690e-01 0.035 0 0
Adaptive Immune System R-HSA-1280218 9.221179e-01 0.035 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.224079e-01 0.035 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 9.224079e-01 0.035 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.224079e-01 0.035 0 0
Centrosome maturation R-HSA-380287 9.248225e-01 0.034 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.248225e-01 0.034 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.262812e-01 0.033 0 0
Signaling by SCF-KIT R-HSA-1433557 9.262812e-01 0.033 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 9.275427e-01 0.033 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.282867e-01 0.032 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.299613e-01 0.032 0 0
Proteasome assembly R-HSA-9907900 9.299613e-01 0.032 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.299613e-01 0.032 0 0
G1 Phase R-HSA-69236 9.299613e-01 0.032 0 0
Cyclin D associated events in G1 R-HSA-69231 9.299613e-01 0.032 0 0
Translation of Structural Proteins R-HSA-9694635 9.308242e-01 0.031 0 0
Platelet degranulation R-HSA-114608 9.311538e-01 0.031 0 0
Opioid Signalling R-HSA-111885 9.326616e-01 0.030 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.334579e-01 0.030 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.334579e-01 0.030 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.334579e-01 0.030 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.336524e-01 0.030 0 0
Interleukin-10 signaling R-HSA-6783783 9.336524e-01 0.030 0 0
Sensory processing of sound R-HSA-9659379 9.363708e-01 0.029 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.367802e-01 0.028 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.377357e-01 0.028 0 0
Reproduction R-HSA-1474165 9.397994e-01 0.027 0 0
NGF-stimulated transcription R-HSA-9031628 9.429359e-01 0.026 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.429359e-01 0.026 0 0
Gluconeogenesis R-HSA-70263 9.429359e-01 0.026 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.439062e-01 0.025 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.440353e-01 0.025 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.440353e-01 0.025 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.456221e-01 0.024 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.462236e-01 0.024 0 0
Interferon gamma signaling R-HSA-877300 9.471281e-01 0.024 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 9.484497e-01 0.023 0 0
Azathioprine ADME R-HSA-9748787 9.484929e-01 0.023 0 0
Meiosis R-HSA-1500620 9.505877e-01 0.022 0 0
Meiotic recombination R-HSA-912446 9.510653e-01 0.022 0 0
Complex IV assembly R-HSA-9864848 9.510653e-01 0.022 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.510653e-01 0.022 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.510873e-01 0.022 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.518218e-01 0.021 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.531522e-01 0.021 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.535093e-01 0.021 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.542105e-01 0.020 0 0
Mitochondrial translation R-HSA-5368287 9.557504e-01 0.020 0 0
Signaling by Hedgehog R-HSA-5358351 9.557504e-01 0.020 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.558315e-01 0.020 0 0
Meiotic synapsis R-HSA-1221632 9.558315e-01 0.020 0 0
Nucleotide biosynthesis R-HSA-8956320 9.558315e-01 0.020 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.601339e-01 0.018 0 0
G alpha (z) signalling events R-HSA-418597 9.601339e-01 0.018 0 0
Paracetamol ADME R-HSA-9753281 9.601339e-01 0.018 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.601345e-01 0.018 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.608130e-01 0.017 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.621255e-01 0.017 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.621255e-01 0.017 0 0
MAPK family signaling cascades R-HSA-5683057 9.623337e-01 0.017 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.640178e-01 0.016 0 0
Signaling by Insulin receptor R-HSA-74752 9.663696e-01 0.015 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.663696e-01 0.015 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.663696e-01 0.015 0 0
Metabolism of proteins R-HSA-392499 9.667276e-01 0.015 0 0
Sialic acid metabolism R-HSA-4085001 9.675236e-01 0.014 0 0
Metabolism of polyamines R-HSA-351202 9.691465e-01 0.014 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.706910e-01 0.013 0 0
Neutrophil degranulation R-HSA-6798695 9.727480e-01 0.012 0 0
Mitochondrial translation elongation R-HSA-5389840 9.729108e-01 0.012 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.735449e-01 0.012 0 0
Mitochondrial translation initiation R-HSA-5368286 9.751676e-01 0.011 0 0
Regulation of insulin secretion R-HSA-422356 9.751676e-01 0.011 0 0
Cellular response to hypoxia R-HSA-1234174 9.761234e-01 0.010 0 0
PPARA activates gene expression R-HSA-1989781 9.766159e-01 0.010 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.773170e-01 0.010 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.782517e-01 0.010 0 0
Kidney development R-HSA-9830369 9.784509e-01 0.009 0 0
Nicotinate metabolism R-HSA-196807 9.784509e-01 0.009 0 0
PI Metabolism R-HSA-1483255 9.791485e-01 0.009 0 0
Regulated Necrosis R-HSA-5218859 9.795283e-01 0.009 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.803160e-01 0.009 0 0
Ion channel transport R-HSA-983712 9.810403e-01 0.008 0 0
RSV-host interactions R-HSA-9833110 9.817211e-01 0.008 0 0
Hedgehog 'on' state R-HSA-5632684 9.824480e-01 0.008 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.828266e-01 0.008 0 0
Platelet homeostasis R-HSA-418346 9.832622e-01 0.007 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.833257e-01 0.007 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.833257e-01 0.007 0 0
Purine catabolism R-HSA-74259 9.833257e-01 0.007 0 0
Neddylation R-HSA-8951664 9.837663e-01 0.007 0 0
Integration of energy metabolism R-HSA-163685 9.843957e-01 0.007 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.850077e-01 0.007 0 0
Mitochondrial translation termination R-HSA-5419276 9.853397e-01 0.006 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.857045e-01 0.006 0 0
Iron uptake and transport R-HSA-917937 9.857045e-01 0.006 0 0
Sphingolipid metabolism R-HSA-428157 9.875080e-01 0.005 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.877235e-01 0.005 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.883573e-01 0.005 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.883573e-01 0.005 0 0
Protein localization R-HSA-9609507 9.924789e-01 0.003 0 0
Pyruvate metabolism R-HSA-70268 9.926652e-01 0.003 0 0
Infectious disease R-HSA-5663205 9.926805e-01 0.003 0 0
Peptide ligand-binding receptors R-HSA-375276 9.929184e-01 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.937125e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.940101e-01 0.003 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.940273e-01 0.003 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.943808e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.949923e-01 0.002 0 0
Cardiac conduction R-HSA-5576891 9.954365e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.956394e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.958315e-01 0.002 0 0
Potassium Channels R-HSA-1296071 9.958315e-01 0.002 0 0
Hemostasis R-HSA-109582 9.959702e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.963423e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.964271e-01 0.002 0 0
G alpha (i) signalling events R-HSA-418594 9.964703e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.965875e-01 0.001 0 0
Stimuli-sensing channels R-HSA-2672351 9.978633e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.980722e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.981688e-01 0.001 0 0
Immune System R-HSA-168256 9.983761e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.986552e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.987867e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.987909e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.990125e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.991220e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.991538e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.991963e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.993787e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.994223e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.994297e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.994297e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.994677e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.995490e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.995684e-01 0.000 0 0
Complement cascade R-HSA-166658 9.997666e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.997777e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998054e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998139e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.998197e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.998744e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.998933e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999204e-01 0.000 0 0
Disease R-HSA-1643685 9.999312e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999447e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999638e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999684e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999704e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999765e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999895e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999910e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999933e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999977e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999989e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999989e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999996e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999999e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Signaling by BMP R-HSA-201451 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 6.208489e-08 7.207 0 0
M Phase R-HSA-68886 4.054093e-07 6.392 0 0
Cell Cycle, Mitotic R-HSA-69278 1.290505e-06 5.889 0 0
Mitotic Prometaphase R-HSA-68877 7.306122e-06 5.136 0 0
Chromatin organization R-HSA-4839726 2.754818e-05 4.560 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.872179e-05 4.542 0 0
Signaling by Hippo R-HSA-2028269 5.471727e-05 4.262 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.864168e-05 4.163 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.783421e-05 4.109 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.783421e-05 4.109 0 0
Chromatin modifying enzymes R-HSA-3247509 8.199163e-05 4.086 0 0
Mitotic Anaphase R-HSA-68882 9.739277e-05 4.011 0 0
mRNA Splicing R-HSA-72172 1.086721e-04 3.964 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.072614e-04 3.970 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.255044e-04 3.901 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.241716e-04 3.906 0 0
Metabolism of RNA R-HSA-8953854 1.436412e-04 3.843 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.941705e-04 3.712 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.744797e-04 3.427 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.930186e-04 3.406 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.080940e-04 3.216 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.080940e-04 3.216 0 0
G-protein beta:gamma signalling R-HSA-397795 6.210757e-04 3.207 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.210757e-04 3.207 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.210757e-04 3.207 0 0
Apoptotic execution phase R-HSA-75153 5.566137e-04 3.254 0 0
Cell Cycle Checkpoints R-HSA-69620 6.368974e-04 3.196 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.885926e-04 3.103 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.124135e-04 3.090 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.124135e-04 3.090 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.609125e-04 3.017 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.020073e-03 2.991 0 0
G alpha (12/13) signalling events R-HSA-416482 1.017959e-03 2.992 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.070952e-03 2.970 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.203907e-03 2.919 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.164754e-03 2.934 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.166614e-03 2.933 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.203907e-03 2.919 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.245264e-03 2.905 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.411342e-03 2.850 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.546379e-03 2.811 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.629374e-03 2.788 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.629374e-03 2.788 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.727372e-03 2.763 0 0
Cell-Cell communication R-HSA-1500931 1.863550e-03 2.730 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.321348e-03 2.634 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.300796e-03 2.638 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.458227e-03 2.609 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.481546e-03 2.605 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.657929e-03 2.575 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.866223e-03 2.543 0 0
Apoptosis R-HSA-109581 3.007325e-03 2.522 0 0
Activation of BH3-only proteins R-HSA-114452 3.044138e-03 2.517 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.168050e-03 2.499 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.168050e-03 2.499 0 0
Centrosome maturation R-HSA-380287 3.441640e-03 2.463 0 0
Separation of Sister Chromatids R-HSA-2467813 3.550330e-03 2.450 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.533858e-03 2.452 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.523655e-03 2.453 0 0
G2/M Checkpoints R-HSA-69481 3.790747e-03 2.421 0 0
Programmed Cell Death R-HSA-5357801 3.868476e-03 2.412 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.043597e-03 2.393 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.099099e-03 2.387 0 0
Cell junction organization R-HSA-446728 4.176187e-03 2.379 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.416452e-03 2.355 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.863973e-03 2.313 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 5.108406e-03 2.292 0 0
Presynaptic function of Kainate receptors R-HSA-500657 5.108406e-03 2.292 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.350605e-03 2.272 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.456612e-03 2.263 0 0
Membrane Trafficking R-HSA-199991 5.564858e-03 2.255 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.905867e-03 2.229 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.154548e-03 2.211 0 0
Mitotic Prophase R-HSA-68875 6.243870e-03 2.205 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.333862e-03 2.198 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.345471e-03 2.198 0 0
NRAGE signals death through JNK R-HSA-193648 7.081462e-03 2.150 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.649385e-03 2.116 0 0
Regulation of TP53 Activity R-HSA-5633007 7.748197e-03 2.111 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.082547e-02 1.966 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.082547e-02 1.966 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.082547e-02 1.966 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.082547e-02 1.966 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.082547e-02 1.966 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.082547e-02 1.966 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.082547e-02 1.966 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.082547e-02 1.966 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.082547e-02 1.966 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.082547e-02 1.966 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.082547e-02 1.966 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.058604e-02 1.975 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.480278e-03 2.023 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.480278e-03 2.023 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.480278e-03 2.023 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 9.172893e-03 2.037 0 0
Signaling by RAS mutants R-HSA-6802949 9.480278e-03 2.023 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.006190e-02 1.997 0 0
Signaling by ALK in cancer R-HSA-9700206 1.006190e-02 1.997 0 0
PKMTs methylate histone lysines R-HSA-3214841 9.426048e-03 2.026 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.184235e-03 2.037 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.191058e-02 1.924 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.191058e-02 1.924 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.202047e-02 1.920 0 0
Unwinding of DNA R-HSA-176974 1.226579e-02 1.911 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.216304e-02 1.915 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.203177e-02 1.920 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.253786e-02 1.902 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.264965e-02 1.898 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.339759e-02 1.873 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.347192e-02 1.871 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.517499e-02 1.819 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.449153e-02 1.839 0 0
mTORC1-mediated signalling R-HSA-166208 1.527665e-02 1.816 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.553799e-02 1.809 0 0
Striated Muscle Contraction R-HSA-390522 1.681557e-02 1.774 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.658334e-02 1.780 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.672850e-02 1.777 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.657086e-02 1.781 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.731269e-02 1.762 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.696708e-02 1.770 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.681308e-02 1.774 0 0
G2/M Transition R-HSA-69275 1.837011e-02 1.736 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.839286e-02 1.735 0 0
Aggrephagy R-HSA-9646399 1.935885e-02 1.713 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.943502e-02 1.711 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.963857e-02 1.707 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.975969e-02 1.704 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.175128e-02 1.663 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.175128e-02 1.663 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.175128e-02 1.663 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.175128e-02 1.663 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.175128e-02 1.663 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.175128e-02 1.663 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.096030e-02 1.679 0 0
Rap1 signalling R-HSA-392517 2.034172e-02 1.692 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.034172e-02 1.692 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.075525e-02 1.683 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.184525e-02 1.661 0 0
snRNP Assembly R-HSA-191859 2.188946e-02 1.660 0 0
Metabolism of non-coding RNA R-HSA-194441 2.188946e-02 1.660 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.318608e-02 1.635 0 0
Signal Transduction R-HSA-162582 2.489272e-02 1.604 1 0
Cap-dependent Translation Initiation R-HSA-72737 2.490109e-02 1.604 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.490109e-02 1.604 0 0
Tight junction interactions R-HSA-420029 2.594266e-02 1.586 0 0
Activation of RAC1 R-HSA-428540 2.860926e-02 1.543 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.860926e-02 1.543 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.698220e-02 1.569 0 0
Integration of provirus R-HSA-162592 2.860926e-02 1.543 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.612173e-02 1.583 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.869380e-02 1.542 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.961335e-02 1.529 0 0
Myogenesis R-HSA-525793 3.042828e-02 1.517 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.042828e-02 1.517 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.103047e-02 1.508 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.103047e-02 1.508 0 0
rRNA processing R-HSA-72312 3.145373e-02 1.502 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.205805e-02 1.494 0 0
Regulation of CDH1 Function R-HSA-9764561 3.554192e-02 1.449 0 0
Cilium Assembly R-HSA-5617833 3.567865e-02 1.448 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.482162e-02 1.458 0 0
Death Receptor Signaling R-HSA-73887 3.642012e-02 1.439 0 0
SARS-CoV Infections R-HSA-9679506 3.371604e-02 1.472 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.689661e-02 1.433 0 0
Nervous system development R-HSA-9675108 3.691384e-02 1.433 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.741309e-02 1.427 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.762344e-02 1.425 0 0
HSF1-dependent transactivation R-HSA-3371571 3.800045e-02 1.420 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.928821e-02 1.406 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.014315e-02 1.396 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.093430e-02 1.388 0 0
Notch-HLH transcription pathway R-HSA-350054 4.124106e-02 1.385 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.216994e-02 1.375 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 4.549334e-02 1.342 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 4.549334e-02 1.342 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 4.549334e-02 1.342 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.544646e-02 1.342 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.544646e-02 1.342 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.664762e-02 1.331 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.515104e-02 1.345 0 0
Protein folding R-HSA-391251 4.396652e-02 1.357 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.544646e-02 1.342 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.549334e-02 1.342 0 0
Interleukin-12 family signaling R-HSA-447115 4.788869e-02 1.320 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.797795e-02 1.319 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.806662e-02 1.318 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.130129e-02 1.290 0 0
Signaling by TGFB family members R-HSA-9006936 5.140494e-02 1.289 1 0
Translation initiation complex formation R-HSA-72649 5.144181e-02 1.289 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.178284e-02 1.286 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.218343e-02 1.282 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.296134e-02 1.276 0 0
2-LTR circle formation R-HSA-164843 6.069746e-02 1.217 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.069746e-02 1.217 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.078861e-02 1.216 0 0
MAP2K and MAPK activation R-HSA-5674135 5.374087e-02 1.270 0 0
Cellular response to heat stress R-HSA-3371556 5.744272e-02 1.241 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.557072e-02 1.255 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.653380e-02 1.248 0 0
MTOR signalling R-HSA-165159 5.977797e-02 1.223 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 5.628466e-02 1.250 0 0
Gene expression (Transcription) R-HSA-74160 5.992331e-02 1.222 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.557072e-02 1.255 0 0
Neurodegenerative Diseases R-HSA-8863678 5.557072e-02 1.255 0 0
Cell-cell junction organization R-HSA-421270 5.354101e-02 1.271 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.597029e-02 1.252 0 0
Interleukin-12 signaling R-HSA-9020591 5.688887e-02 1.245 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.104828e-02 1.214 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.204787e-02 1.207 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.260044e-02 1.203 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.260044e-02 1.203 0 0
TGFBR3 expression R-HSA-9839394 6.376408e-02 1.195 0 0
Interleukin-7 signaling R-HSA-1266695 6.376408e-02 1.195 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.416828e-02 1.193 0 0
Nephrin family interactions R-HSA-373753 6.570313e-02 1.182 0 0
Opioid Signalling R-HSA-111885 6.596844e-02 1.181 0 0
Axon guidance R-HSA-422475 6.706463e-02 1.174 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.723640e-02 1.172 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.752927e-02 1.171 0 0
Signaling by ROBO receptors R-HSA-376176 6.836012e-02 1.165 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.854618e-02 1.164 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.856056e-02 1.164 0 0
Regulation of cortical dendrite branching R-HSA-8985801 7.523522e-02 1.124 0 0
Autointegration results in viral DNA circles R-HSA-177539 8.229441e-02 1.085 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.598647e-02 1.119 0 0
G-protein activation R-HSA-202040 7.598647e-02 1.119 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.688368e-02 1.114 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.389607e-02 1.131 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.598647e-02 1.119 0 0
Prolonged ERK activation events R-HSA-169893 7.753052e-02 1.111 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 8.229441e-02 1.085 0 0
PTEN Regulation R-HSA-6807070 8.065410e-02 1.093 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.708974e-02 1.113 0 0
DAG and IP3 signaling R-HSA-1489509 8.045510e-02 1.094 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.523522e-02 1.124 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.223658e-02 1.085 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.150828e-02 1.146 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.150828e-02 1.146 0 0
Cellular responses to stimuli R-HSA-8953897 8.142447e-02 1.089 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 8.229441e-02 1.085 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.598647e-02 1.119 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.580221e-02 1.067 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.712805e-02 1.060 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.720135e-02 1.059 0 0
Kinesins R-HSA-983189 8.720135e-02 1.059 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.760520e-02 1.057 0 0
Smooth Muscle Contraction R-HSA-445355 8.799835e-02 1.056 0 0
Disorders of Developmental Biology R-HSA-9675151 9.068217e-02 1.042 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.068217e-02 1.042 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 9.088117e-02 1.042 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.271551e-02 1.033 0 0
RAF activation R-HSA-5673000 9.529949e-02 1.021 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.062622e-01 0.974 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.094351e-01 0.961 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.042836e-01 0.982 0 0
SOS-mediated signalling R-HSA-112412 1.042836e-01 0.982 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 1.042836e-01 0.982 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.042836e-01 0.982 0 0
Pervasive developmental disorders R-HSA-9005895 1.081998e-01 0.966 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.081998e-01 0.966 0 0
Disorders of Nervous System Development R-HSA-9697154 1.081998e-01 0.966 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.081998e-01 0.966 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.049052e-01 0.979 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.049052e-01 0.979 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.115203e-01 0.953 0 0
Activation of the pre-replicative complex R-HSA-68962 1.150986e-01 0.939 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.121034e-01 0.950 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.081998e-01 0.966 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.081998e-01 0.966 0 0
HDACs deacetylate histones R-HSA-3214815 1.036840e-01 0.984 0 0
ESR-mediated signaling R-HSA-8939211 1.093304e-01 0.961 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.016721e-01 0.993 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.071057e-01 0.970 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.094351e-01 0.961 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.119225e-01 0.951 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.000239e-01 1.000 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.150986e-01 0.939 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.042836e-01 0.982 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.730810e-02 1.012 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.042836e-01 0.982 0 0
Potential therapeutics for SARS R-HSA-9679191 1.000724e-01 1.000 0 0
Glucagon-type ligand receptors R-HSA-420092 1.034709e-01 0.985 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.000724e-01 1.000 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.155016e-01 0.937 0 0
HSF1 activation R-HSA-3371511 1.160048e-01 0.936 0 0
Calmodulin induced events R-HSA-111933 1.160048e-01 0.936 0 0
CaM pathway R-HSA-111997 1.160048e-01 0.936 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.178080e-01 0.929 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.012383e-01 0.696 0 0
Hereditary fructose intolerance R-HSA-5657560 2.012383e-01 0.696 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.012383e-01 0.696 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.012383e-01 0.696 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.012383e-01 0.696 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.012383e-01 0.696 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.468109e-01 0.833 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.468109e-01 0.833 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 2.861264e-01 0.543 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.861264e-01 0.543 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 2.861264e-01 0.543 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.861264e-01 0.543 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.861264e-01 0.543 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.861264e-01 0.543 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.861264e-01 0.543 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.861264e-01 0.543 0 0
IRS activation R-HSA-74713 1.863022e-01 0.730 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.863022e-01 0.730 0 0
Formation of annular gap junctions R-HSA-196025 1.282946e-01 0.892 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.282946e-01 0.892 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.282946e-01 0.892 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.540400e-01 0.812 0 0
ARMS-mediated activation R-HSA-170984 1.540400e-01 0.812 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.540400e-01 0.812 0 0
Gap junction degradation R-HSA-190873 1.540400e-01 0.812 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.540400e-01 0.812 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.270381e-01 0.644 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.270381e-01 0.644 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.270381e-01 0.644 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.270381e-01 0.644 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.270381e-01 0.644 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.619975e-01 0.441 0 0
Signalling to ERK5 R-HSA-198765 3.619975e-01 0.441 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.619975e-01 0.441 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.619975e-01 0.441 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.619975e-01 0.441 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.619975e-01 0.441 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.619975e-01 0.441 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.619975e-01 0.441 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.619975e-01 0.441 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.268737e-01 0.897 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.683086e-01 0.571 0 0
Ephrin signaling R-HSA-3928664 1.201542e-01 0.920 0 0
PECAM1 interactions R-HSA-210990 2.095764e-01 0.679 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.678174e-01 0.775 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.678174e-01 0.775 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.255267e-01 0.901 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.898306e-01 0.722 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.095406e-01 0.509 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.095406e-01 0.509 0 0
MET activates STAT3 R-HSA-8875791 4.298090e-01 0.367 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.298090e-01 0.367 0 0
PLC-gamma1 signalling R-HSA-167021 4.298090e-01 0.367 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.298090e-01 0.367 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.298090e-01 0.367 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.298090e-01 0.367 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.298090e-01 0.367 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.298090e-01 0.367 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 4.298090e-01 0.367 0 0
Signalling to STAT3 R-HSA-198745 4.298090e-01 0.367 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.298090e-01 0.367 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.298090e-01 0.367 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 1.398928e-01 0.854 0 0
G protein gated Potassium channels R-HSA-1296059 1.398928e-01 0.854 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 1.398928e-01 0.854 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.714700e-01 0.766 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.714700e-01 0.766 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.126920e-01 0.672 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.686636e-01 0.571 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.686636e-01 0.571 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.686636e-01 0.571 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.686636e-01 0.571 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.686636e-01 0.571 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.902015e-01 0.721 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.902015e-01 0.721 0 0
Type I hemidesmosome assembly R-HSA-446107 3.502763e-01 0.456 0 0
FGFR3 mutant receptor activation R-HSA-2033514 2.989046e-01 0.524 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.989046e-01 0.524 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 2.989046e-01 0.524 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.678872e-01 0.775 0 0
Late endosomal microautophagy R-HSA-9615710 2.041364e-01 0.690 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.041364e-01 0.690 0 0
Attenuation phase R-HSA-3371568 1.639071e-01 0.785 0 0
mRNA 3'-end processing R-HSA-72187 1.437855e-01 0.842 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.593431e-01 0.798 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.593431e-01 0.798 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.293106e-01 0.482 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 3.293106e-01 0.482 0 0
WNT mediated activation of DVL R-HSA-201688 3.901558e-01 0.409 0 0
Calcineurin activates NFAT R-HSA-2025928 3.901558e-01 0.409 0 0
ALK mutants bind TKIs R-HSA-9700645 3.901558e-01 0.409 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.904165e-01 0.309 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.904165e-01 0.309 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.904165e-01 0.309 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.904165e-01 0.309 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.904165e-01 0.309 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.904165e-01 0.309 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.904165e-01 0.309 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.904165e-01 0.309 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.838817e-01 0.735 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.099173e-01 0.509 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.580372e-01 0.588 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.596828e-01 0.444 0 0
Erythropoietin activates RAS R-HSA-9027284 3.596828e-01 0.444 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.596828e-01 0.444 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.925015e-01 0.534 0 0
Peptide chain elongation R-HSA-156902 1.378989e-01 0.860 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.767997e-01 0.558 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.767997e-01 0.558 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.289012e-01 0.368 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.289012e-01 0.368 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.625327e-01 0.581 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.141125e-01 0.503 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.141125e-01 0.503 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.141125e-01 0.503 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.301042e-01 0.886 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.482764e-01 0.829 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.425455e-01 0.846 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.628445e-01 0.788 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.958643e-01 0.529 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.898441e-01 0.409 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.796276e-01 0.553 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.796276e-01 0.553 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.796276e-01 0.553 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.716508e-01 0.765 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.602034e-01 0.443 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.602034e-01 0.443 0 0
Meiotic synapsis R-HSA-1221632 2.516380e-01 0.599 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.516380e-01 0.599 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.359182e-01 0.474 0 0
HIV elongation arrest and recovery R-HSA-167287 3.359182e-01 0.474 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.359182e-01 0.474 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.346718e-01 0.475 0 0
Signaling by Erythropoietin R-HSA-9006335 3.578419e-01 0.446 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.578419e-01 0.446 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.196383e-01 0.377 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.445850e-01 0.264 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.445850e-01 0.264 0 0
Defective F9 activation R-HSA-9673221 5.445850e-01 0.264 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.445850e-01 0.264 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.445850e-01 0.264 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 5.445850e-01 0.264 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.445850e-01 0.264 0 0
Activation of GABAB receptors R-HSA-991365 3.323365e-01 0.478 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.543027e-01 0.451 0 0
DAP12 signaling R-HSA-2424491 3.798102e-01 0.420 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.798102e-01 0.420 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.373733e-01 0.625 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.373733e-01 0.625 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.261479e-01 0.487 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.489297e-01 0.348 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.055989e-01 0.515 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.017531e-01 0.396 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.017531e-01 0.396 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.966758e-01 0.528 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.155758e-01 0.501 0 0
Deadenylation of mRNA R-HSA-429947 4.351882e-01 0.361 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.022095e-01 0.299 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.022095e-01 0.299 0 0
Transcription of the HIV genome R-HSA-167172 3.517964e-01 0.454 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.134640e-01 0.384 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.776021e-01 0.321 0 0
PKA activation R-HSA-163615 4.776021e-01 0.321 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.043667e-01 0.393 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.453036e-01 0.351 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.526358e-01 0.344 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.667926e-01 0.331 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.055577e-01 0.296 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.055577e-01 0.296 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.365158e-01 0.270 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.929983e-01 0.227 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.929983e-01 0.227 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.929983e-01 0.227 0 0
Signaling by MAPK mutants R-HSA-9652817 5.929983e-01 0.227 0 0
Viral mRNA Translation R-HSA-192823 4.056364e-01 0.392 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.327153e-01 0.274 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.327153e-01 0.274 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.327153e-01 0.274 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.327153e-01 0.274 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.327153e-01 0.274 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.691565e-01 0.245 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.691565e-01 0.245 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.691565e-01 0.245 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.590099e-01 0.253 0 0
Neutrophil degranulation R-HSA-6798695 5.022705e-01 0.299 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.753458e-01 0.240 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.753458e-01 0.240 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.843903e-01 0.233 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.886908e-01 0.230 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.395268e-01 0.621 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.263062e-01 0.645 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.096186e-01 0.679 0 0
RNA Polymerase III Transcription R-HSA-74158 3.543027e-01 0.451 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.271921e-01 0.896 0 0
Integrin signaling R-HSA-354192 1.537994e-01 0.813 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.533101e-01 0.257 0 0
EGFR downregulation R-HSA-182971 4.017531e-01 0.396 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.925015e-01 0.534 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.868563e-01 0.313 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.407500e-01 0.618 0 0
Interleukin-15 signaling R-HSA-8983432 2.686636e-01 0.571 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.421912e-01 0.266 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.837072e-01 0.234 0 0
Signaling by FGFR3 R-HSA-5654741 3.862940e-01 0.413 0 0
Recycling pathway of L1 R-HSA-437239 1.714082e-01 0.766 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.032057e-01 0.298 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.477045e-01 0.831 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.216487e-01 0.654 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.989046e-01 0.524 0 0
DNA Double Strand Break Response R-HSA-5693606 3.371930e-01 0.472 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.902015e-01 0.721 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.216487e-01 0.654 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.170664e-01 0.286 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.282946e-01 0.892 0 0
Ribosome-associated quality control R-HSA-9948299 1.616758e-01 0.791 0 0
Co-stimulation by CD28 R-HSA-389356 2.967835e-01 0.528 0 0
GABA B receptor activation R-HSA-977444 3.323365e-01 0.478 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.838167e-01 0.315 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.688976e-01 0.329 0 0
Interferon alpha/beta signaling R-HSA-909733 5.872466e-01 0.231 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.429769e-01 0.265 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.887808e-01 0.311 0 0
Polo-like kinase mediated events R-HSA-156711 1.201542e-01 0.920 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.969884e-01 0.527 0 0
Nucleotide Excision Repair R-HSA-5696398 4.428068e-01 0.354 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.544910e-01 0.811 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.770455e-01 0.752 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.058269e-01 0.686 0 0
ERK/MAPK targets R-HSA-198753 5.590099e-01 0.253 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.190958e-01 0.659 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.812291e-01 0.742 0 0
DCC mediated attractive signaling R-HSA-418885 1.678174e-01 0.775 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.901558e-01 0.409 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.596828e-01 0.444 0 0
Signaling by BMP R-HSA-201451 3.141125e-01 0.503 1 1
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.126920e-01 0.672 0 0
UCH proteinases R-HSA-5689603 4.700547e-01 0.328 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 4.880189e-01 0.312 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.282946e-01 0.892 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.095406e-01 0.509 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.095406e-01 0.509 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.096186e-01 0.679 0 0
Interleukin-21 signaling R-HSA-9020958 3.901558e-01 0.409 0 0
PI3K/AKT activation R-HSA-198203 4.289012e-01 0.368 0 0
Homology Directed Repair R-HSA-5693538 1.677572e-01 0.775 0 0
GPER1 signaling R-HSA-9634597 2.967835e-01 0.528 0 0
Eukaryotic Translation Termination R-HSA-72764 2.190958e-01 0.659 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.667926e-01 0.331 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.707512e-01 0.768 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.151739e-01 0.501 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.130097e-01 0.504 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.502390e-01 0.456 0 0
Rab regulation of trafficking R-HSA-9007101 2.268266e-01 0.644 0 0
Interleukin-9 signaling R-HSA-8985947 3.502763e-01 0.456 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.501832e-01 0.602 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.958643e-01 0.529 0 0
EPH-Ephrin signaling R-HSA-2682334 2.623395e-01 0.581 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.569799e-01 0.590 0 0
FOXO-mediated transcription R-HSA-9614085 2.606842e-01 0.584 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.866600e-01 0.232 0 0
Thromboxane signalling through TP receptor R-HSA-428930 1.255267e-01 0.901 0 0
Negative regulation of MET activity R-HSA-6807004 1.535027e-01 0.814 0 0
Formation of axial mesoderm R-HSA-9796292 2.989046e-01 0.524 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.901558e-01 0.409 0 0
Regulation of gap junction activity R-HSA-191650 4.904165e-01 0.309 0 0
Trafficking of AMPA receptors R-HSA-399719 2.396345e-01 0.620 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.767997e-01 0.558 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.796276e-01 0.553 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.445850e-01 0.264 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 5.022095e-01 0.299 0 0
Translesion Synthesis by POLH R-HSA-110320 5.055577e-01 0.296 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.055577e-01 0.296 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.365158e-01 0.270 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.294964e-01 0.276 0 0
Interleukin-2 signaling R-HSA-9020558 4.663031e-01 0.331 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.286209e-01 0.641 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 2.362651e-01 0.627 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.798102e-01 0.420 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.838817e-01 0.735 0 0
Signal attenuation R-HSA-74749 1.812291e-01 0.742 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.388074e-01 0.622 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.707512e-01 0.768 0 0
Long-term potentiation R-HSA-9620244 4.596910e-01 0.338 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.353359e-01 0.361 0 0
Signaling by NOTCH4 R-HSA-9013694 2.175493e-01 0.662 0 0
G alpha (z) signalling events R-HSA-418597 1.770455e-01 0.752 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.533101e-01 0.257 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.108936e-01 0.386 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.511065e-01 0.455 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.863022e-01 0.730 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 1.282946e-01 0.892 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 1.540400e-01 0.812 0 0
Abacavir transmembrane transport R-HSA-2161517 2.683086e-01 0.571 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.201542e-01 0.920 0 0
PTK6 Expression R-HSA-8849473 3.095406e-01 0.509 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.686636e-01 0.571 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.049052e-01 0.688 0 0
PTK6 Activates STAT3 R-HSA-8849474 5.445850e-01 0.264 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.445850e-01 0.264 0 0
PTK6 Down-Regulation R-HSA-8849472 5.445850e-01 0.264 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.445850e-01 0.264 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.489297e-01 0.348 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.884001e-01 0.411 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.744998e-01 0.427 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.929983e-01 0.227 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.327153e-01 0.274 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.590099e-01 0.253 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.471556e-01 0.262 0 0
G-protein mediated events R-HSA-112040 3.371930e-01 0.472 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.399266e-01 0.854 0 0
Signaling by NOTCH R-HSA-157118 3.938738e-01 0.405 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.921892e-01 0.534 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.224183e-01 0.374 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.784111e-01 0.555 0 0
RNA Polymerase I Transcription R-HSA-73864 4.992583e-01 0.302 0 0
Signal amplification R-HSA-392518 3.151739e-01 0.501 0 0
DNA Repair R-HSA-73894 4.404514e-01 0.356 0 0
Ca2+ pathway R-HSA-4086398 2.062733e-01 0.686 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.437855e-01 0.842 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.596828e-01 0.444 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.952607e-01 0.709 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.280625e-01 0.642 0 0
Meiosis R-HSA-1500620 4.729322e-01 0.325 0 0
Signaling by NOTCH3 R-HSA-9012852 4.128363e-01 0.384 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.088457e-01 0.680 0 0
Signaling by EGFR R-HSA-177929 2.957414e-01 0.529 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 4.911782e-01 0.309 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.958273e-01 0.305 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.958273e-01 0.305 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.958273e-01 0.305 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.958273e-01 0.305 0 0
Frs2-mediated activation R-HSA-170968 1.268737e-01 0.897 0 0
Post NMDA receptor activation events R-HSA-438064 5.144426e-01 0.289 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.976571e-01 0.704 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.270381e-01 0.644 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.298090e-01 0.367 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.445850e-01 0.264 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.103826e-01 0.387 0 0
Heme signaling R-HSA-9707616 3.884001e-01 0.411 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.929983e-01 0.227 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.074992e-01 0.295 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.327153e-01 0.274 0 0
NGF-stimulated transcription R-HSA-9031628 1.838817e-01 0.735 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.578419e-01 0.446 0 0
Interleukin-23 signaling R-HSA-9020933 3.502763e-01 0.456 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.494737e-01 0.603 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.563347e-01 0.806 0 0
HIV Life Cycle R-HSA-162587 1.372103e-01 0.863 0 0
Cellular Senescence R-HSA-2559583 1.377667e-01 0.861 0 0
Vesicle-mediated transport R-HSA-5653656 1.355516e-01 0.868 0 0
Signaling by WNT R-HSA-195721 5.716932e-01 0.243 0 0
Neurofascin interactions R-HSA-447043 2.683086e-01 0.571 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.293109e-01 0.640 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.590099e-01 0.253 0 0
tRNA processing in the nucleus R-HSA-6784531 5.281314e-01 0.277 0 0
Signaling by VEGF R-HSA-194138 3.149362e-01 0.502 0 0
Signalling to ERKs R-HSA-187687 1.976571e-01 0.704 0 0
PLC beta mediated events R-HSA-112043 2.527288e-01 0.597 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.901558e-01 0.409 0 0
Ca-dependent events R-HSA-111996 2.049052e-01 0.688 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.159459e-01 0.666 0 0
HIV Infection R-HSA-162906 2.317512e-01 0.635 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.257311e-01 0.279 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.351882e-01 0.361 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.055577e-01 0.296 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.359182e-01 0.474 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.602034e-01 0.443 0 0
Signaling by NOTCH1 R-HSA-1980143 3.466613e-01 0.460 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.477045e-01 0.831 0 0
HATs acetylate histones R-HSA-3214847 1.818685e-01 0.740 0 0
RUNX2 regulates bone development R-HSA-8941326 2.132677e-01 0.671 0 0
Signaling by MET R-HSA-6806834 5.280183e-01 0.277 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.032057e-01 0.298 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.032057e-01 0.298 0 0
RNA Polymerase II Transcription R-HSA-73857 1.295777e-01 0.887 0 0
Autophagy R-HSA-9612973 3.178270e-01 0.498 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.012383e-01 0.696 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.861264e-01 0.543 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.861264e-01 0.543 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.540400e-01 0.812 0 0
Proton/oligopeptide cotransporters R-HSA-427975 2.270381e-01 0.644 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.619975e-01 0.441 0 0
C6 deamination of adenosine R-HSA-75102 3.619975e-01 0.441 0 0
Regulation of KIT signaling R-HSA-1433559 1.467879e-01 0.833 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.683086e-01 0.571 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.201542e-01 0.920 0 0
Bicarbonate transporters R-HSA-425381 2.095764e-01 0.679 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.898306e-01 0.722 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.095406e-01 0.509 0 0
MET interacts with TNS proteins R-HSA-8875513 4.298090e-01 0.367 0 0
Signaling by LTK R-HSA-9842663 2.686636e-01 0.571 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.502763e-01 0.456 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.871529e-01 0.728 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.904165e-01 0.309 0 0
Downstream signal transduction R-HSA-186763 2.396345e-01 0.620 0 0
Regulation of CDH11 function R-HSA-9762292 4.289012e-01 0.368 0 0
Signaling by ALK R-HSA-201556 2.625327e-01 0.581 0 0
Orc1 removal from chromatin R-HSA-68949 2.374448e-01 0.624 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.151739e-01 0.501 0 0
Reelin signalling pathway R-HSA-8866376 5.445850e-01 0.264 0 0
TBC/RABGAPs R-HSA-8854214 3.502390e-01 0.456 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.489297e-01 0.348 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.055989e-01 0.515 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.937498e-01 0.405 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.776021e-01 0.321 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.549062e-01 0.450 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.884001e-01 0.411 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.838167e-01 0.315 0 0
Regulation of IFNG signaling R-HSA-877312 5.365158e-01 0.270 0 0
Synthesis of PS R-HSA-1483101 5.929983e-01 0.227 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.691565e-01 0.245 0 0
Generic Transcription Pathway R-HSA-212436 4.086385e-01 0.389 0 0
Cellular responses to stress R-HSA-2262752 1.305070e-01 0.884 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.771294e-01 0.752 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.824903e-01 0.549 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.978443e-01 0.526 0 0
Host Interactions of HIV factors R-HSA-162909 2.944892e-01 0.531 0 0
Synthesis of DNA R-HSA-69239 4.675348e-01 0.330 0 0
Interferon gamma signaling R-HSA-877300 4.305509e-01 0.366 0 0
MAPK family signaling cascades R-HSA-5683057 4.729613e-01 0.325 0 0
Neurexins and neuroligins R-HSA-6794361 2.374448e-01 0.624 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.720058e-01 0.326 0 0
DNA strand elongation R-HSA-69190 1.402866e-01 0.853 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.533101e-01 0.257 0 0
Biotin transport and metabolism R-HSA-196780 3.596828e-01 0.444 0 0
Signaling by NTRKs R-HSA-166520 1.309001e-01 0.883 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.280287e-01 0.277 0 0
L1CAM interactions R-HSA-373760 1.528140e-01 0.816 0 0
Signaling by FGFR in disease R-HSA-1226099 3.191602e-01 0.496 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.055577e-01 0.296 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.909168e-01 0.719 0 0
Deubiquitination R-HSA-5688426 3.100789e-01 0.509 0 0
Adherens junctions interactions R-HSA-418990 1.752803e-01 0.756 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.331077e-01 0.363 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.969731e-01 0.401 0 0
Signaling by ERBB2 R-HSA-1227986 2.393843e-01 0.621 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.812291e-01 0.742 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.255267e-01 0.901 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.495240e-01 0.825 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.099173e-01 0.509 0 0
Inwardly rectifying K+ channels R-HSA-1296065 2.580372e-01 0.588 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.196383e-01 0.377 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.905537e-01 0.408 0 0
Interferon Signaling R-HSA-913531 2.632591e-01 0.580 0 0
Negative regulation of FLT3 R-HSA-9706369 3.898441e-01 0.409 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.602034e-01 0.443 0 0
Gap junction trafficking and regulation R-HSA-157858 4.583142e-01 0.339 0 0
Macroautophagy R-HSA-1632852 4.142167e-01 0.383 0 0
Signaling by NODAL R-HSA-1181150 5.327153e-01 0.274 0 0
DARPP-32 events R-HSA-180024 5.533101e-01 0.257 0 0
HDMs demethylate histones R-HSA-3214842 2.711645e-01 0.567 0 0
Protein ubiquitination R-HSA-8852135 3.328540e-01 0.478 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.268737e-01 0.897 0 0
Nef and signal transduction R-HSA-164944 2.683086e-01 0.571 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.901558e-01 0.409 0 0
Interleukin-27 signaling R-HSA-9020956 4.289012e-01 0.368 0 0
S Phase R-HSA-69242 1.309001e-01 0.883 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.937498e-01 0.405 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.022095e-01 0.299 0 0
Aquaporin-mediated transport R-HSA-445717 3.727240e-01 0.429 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.667926e-01 0.331 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.929983e-01 0.227 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.590099e-01 0.253 0 0
Ub-specific processing proteases R-HSA-5689880 5.783877e-01 0.238 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.911782e-01 0.309 0 0
Regulation of insulin secretion R-HSA-422356 4.521248e-01 0.345 0 0
Glycolysis R-HSA-70171 2.715112e-01 0.566 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.771765e-01 0.557 0 0
Netrin-1 signaling R-HSA-373752 5.287855e-01 0.277 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 2.216487e-01 0.654 0 0
Integration of energy metabolism R-HSA-163685 2.067675e-01 0.685 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.162340e-01 0.500 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 5.055577e-01 0.296 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.453601e-01 0.462 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.678872e-01 0.775 0 0
Signaling by Leptin R-HSA-2586552 1.812291e-01 0.742 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.843903e-01 0.233 0 0
Semaphorin interactions R-HSA-373755 2.801334e-01 0.553 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.700491e-01 0.244 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 5.055577e-01 0.296 0 0
Interleukin-37 signaling R-HSA-9008059 5.753458e-01 0.240 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.489297e-01 0.348 0 0
Interleukin-6 signaling R-HSA-1059683 5.691565e-01 0.245 0 0
Gap junction trafficking R-HSA-190828 5.287855e-01 0.277 0 0
Glucose metabolism R-HSA-70326 5.053539e-01 0.296 0 0
Hedgehog 'off' state R-HSA-5610787 5.914910e-01 0.228 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.145722e-01 0.502 0 0
Muscle contraction R-HSA-397014 1.884009e-01 0.725 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.439989e-01 0.264 0 0
Signaling by PTK6 R-HSA-8848021 5.439989e-01 0.264 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.270381e-01 0.644 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.388074e-01 0.622 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 3.095406e-01 0.509 0 0
Intracellular oxygen transport R-HSA-8981607 4.298090e-01 0.367 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.298090e-01 0.367 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 2.686636e-01 0.571 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.537994e-01 0.813 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 3.901558e-01 0.409 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.904165e-01 0.309 0 0
Sensory perception of sour taste R-HSA-9729555 4.904165e-01 0.309 0 0
NADE modulates death signalling R-HSA-205025 4.904165e-01 0.309 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.767997e-01 0.558 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.625327e-01 0.581 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.151739e-01 0.501 0 0
Transport of connexons to the plasma membrane R-HSA-190872 4.776021e-01 0.321 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.929983e-01 0.227 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.729322e-01 0.325 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.958273e-01 0.305 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.796276e-01 0.553 0 0
Selective autophagy R-HSA-9663891 4.083914e-01 0.389 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.111438e-01 0.291 0 0
Calnexin/calreticulin cycle R-HSA-901042 4.880189e-01 0.312 0 0
Signaling by TGFBR3 R-HSA-9839373 2.649822e-01 0.577 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.608844e-01 0.443 0 0
Protein hydroxylation R-HSA-9629569 5.327153e-01 0.274 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.111438e-01 0.291 0 0
Gluconeogenesis R-HSA-70263 2.967835e-01 0.528 0 0
Signaling by ERBB4 R-HSA-1236394 5.723079e-01 0.242 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.683086e-01 0.571 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.502763e-01 0.456 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.346718e-01 0.475 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.517964e-01 0.454 0 0
Selenocysteine synthesis R-HSA-2408557 3.809454e-01 0.419 0 0
Nuclear import of Rev protein R-HSA-180746 4.880189e-01 0.312 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.694067e-01 0.245 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.453036e-01 0.351 0 0
FLT3 Signaling R-HSA-9607240 2.969884e-01 0.527 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.886908e-01 0.230 0 0
PKR-mediated signaling R-HSA-9833482 5.280183e-01 0.277 0 0
Viral Infection Pathways R-HSA-9824446 3.689584e-01 0.433 0 0
MHC class II antigen presentation R-HSA-2132295 5.743594e-01 0.241 0 0
Specification of the neural plate border R-HSA-9834899 5.055577e-01 0.296 0 0
Stabilization of p53 R-HSA-69541 5.886908e-01 0.230 0 0
Diseases of DNA repair R-HSA-9675135 4.043667e-01 0.393 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.801334e-01 0.553 0 0
TNF signaling R-HSA-75893 5.785004e-01 0.238 0 0
Sodium/Proton exchangers R-HSA-425986 1.282946e-01 0.892 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.619975e-01 0.441 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.619975e-01 0.441 0 0
The NLRP1 inflammasome R-HSA-844455 4.298090e-01 0.367 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.126920e-01 0.672 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.904165e-01 0.309 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.289012e-01 0.368 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.625327e-01 0.581 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.445850e-01 0.264 0 0
NrCAM interactions R-HSA-447038 5.445850e-01 0.264 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.885729e-01 0.411 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.929983e-01 0.227 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.043667e-01 0.393 0 0
Influenza Infection R-HSA-168255 3.057126e-01 0.515 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.132677e-01 0.671 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.596910e-01 0.338 0 0
Sensory processing of sound R-HSA-9659379 5.137021e-01 0.289 0 0
RMTs methylate histone arginines R-HSA-3214858 5.287855e-01 0.277 0 0
Maturation of nucleoprotein R-HSA-9683610 5.691565e-01 0.245 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.494737e-01 0.603 0 0
Growth hormone receptor signaling R-HSA-982772 4.103826e-01 0.387 0 0
Maturation of nucleoprotein R-HSA-9694631 5.055577e-01 0.296 0 0
RET signaling R-HSA-8853659 3.543027e-01 0.451 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.268737e-01 0.897 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.901558e-01 0.409 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.625327e-01 0.581 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.663031e-01 0.331 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.929983e-01 0.227 0 0
Basigin interactions R-HSA-210991 5.590099e-01 0.253 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.756124e-01 0.560 0 0
Interleukin-35 Signalling R-HSA-8984722 5.365158e-01 0.270 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.694067e-01 0.245 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.604145e-01 0.584 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.396345e-01 0.620 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.908043e-01 0.719 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.887047e-01 0.724 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.989046e-01 0.524 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 4.489297e-01 0.348 0 0
IRE1alpha activates chaperones R-HSA-381070 2.512207e-01 0.600 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.957414e-01 0.529 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 3.293106e-01 0.482 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.931677e-01 0.405 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 5.055577e-01 0.296 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.863022e-01 0.730 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.776021e-01 0.321 0 0
Circadian clock R-HSA-9909396 5.946700e-01 0.226 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.967517e-01 0.224 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.967517e-01 0.224 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.000980e-01 0.222 0 0
Malate-aspartate shuttle R-HSA-9856872 6.000980e-01 0.222 0 0
Signal regulatory protein family interactions R-HSA-391160 6.000980e-01 0.222 0 0
Intraflagellar transport R-HSA-5620924 6.002027e-01 0.222 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.007847e-01 0.221 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.009994e-01 0.221 0 0
HIV Transcription Elongation R-HSA-167169 6.074915e-01 0.216 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.074915e-01 0.216 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.074915e-01 0.216 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.074915e-01 0.216 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.074915e-01 0.216 0 0
Generation of second messenger molecules R-HSA-202433 6.074915e-01 0.216 0 0
Interleukin-2 family signaling R-HSA-451927 6.074915e-01 0.216 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.074915e-01 0.216 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.088185e-01 0.216 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.088185e-01 0.216 0 0
Signaling by KIT in disease R-HSA-9669938 6.088185e-01 0.216 0 0
LDL clearance R-HSA-8964038 6.088185e-01 0.216 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.088185e-01 0.216 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.098844e-01 0.215 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.104462e-01 0.214 0 0
Degradation of CDH1 R-HSA-9766229 6.171226e-01 0.210 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.171226e-01 0.210 0 0
Cellular response to chemical stress R-HSA-9711123 6.190930e-01 0.208 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.212793e-01 0.207 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.234553e-01 0.205 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 6.257870e-01 0.204 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.257870e-01 0.204 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.293327e-01 0.201 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.293327e-01 0.201 0 0
FGFR3 ligand binding and activation R-HSA-190239 6.293327e-01 0.201 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.293327e-01 0.201 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.293327e-01 0.201 0 0
Signaling by Activin R-HSA-1502540 6.293327e-01 0.201 0 0
p75NTR signals via NF-kB R-HSA-193639 6.293327e-01 0.201 0 0
Protein methylation R-HSA-8876725 6.293327e-01 0.201 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.322678e-01 0.199 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.336308e-01 0.198 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.340683e-01 0.198 0 0
Inositol phosphate metabolism R-HSA-1483249 6.353676e-01 0.197 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.362675e-01 0.196 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.362675e-01 0.196 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.362675e-01 0.196 0 0
CREB phosphorylation R-HSA-199920 6.362675e-01 0.196 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.362675e-01 0.196 0 0
Metabolism of vitamin K R-HSA-6806664 6.362675e-01 0.196 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.362675e-01 0.196 0 0
NADPH regeneration R-HSA-389542 6.362675e-01 0.196 0 0
VLDL assembly R-HSA-8866423 6.362675e-01 0.196 0 0
HDL clearance R-HSA-8964011 6.362675e-01 0.196 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.375650e-01 0.195 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.375650e-01 0.195 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.375650e-01 0.195 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.375650e-01 0.195 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.388613e-01 0.195 0 0
GABA receptor activation R-HSA-977443 6.410516e-01 0.193 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.435593e-01 0.191 0 0
HIV Transcription Initiation R-HSA-167161 6.435593e-01 0.191 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.435593e-01 0.191 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.435593e-01 0.191 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.435593e-01 0.191 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.438398e-01 0.191 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.480877e-01 0.188 0 0
Diseases of programmed cell death R-HSA-9645723 6.488316e-01 0.188 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.497127e-01 0.187 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.547220e-01 0.184 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.547779e-01 0.184 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.558190e-01 0.183 0 0
Phosphorylation of the APC/C R-HSA-176412 6.568738e-01 0.183 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.568738e-01 0.183 0 0
Killing mechanisms R-HSA-9664420 6.568738e-01 0.183 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.568738e-01 0.183 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.568738e-01 0.183 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.568738e-01 0.183 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.568738e-01 0.183 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.568738e-01 0.183 0 0
Virus Assembly and Release R-HSA-168268 6.568738e-01 0.183 0 0
Translation R-HSA-72766 6.616955e-01 0.179 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.617933e-01 0.179 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.625212e-01 0.179 0 0
Signaling by Hedgehog R-HSA-5358351 6.659944e-01 0.177 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.676014e-01 0.175 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.702157e-01 0.174 0 0
Signaling by PDGF R-HSA-186797 6.702157e-01 0.174 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.749389e-01 0.171 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.749389e-01 0.171 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.749389e-01 0.171 0 0
FGFR3b ligand binding and activation R-HSA-190371 6.749389e-01 0.171 0 0
Disinhibition of SNARE formation R-HSA-114516 6.749389e-01 0.171 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.749389e-01 0.171 0 0
Recycling of eIF2:GDP R-HSA-72731 6.749389e-01 0.171 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.749389e-01 0.171 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.749389e-01 0.171 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.749389e-01 0.171 0 0
VLDL clearance R-HSA-8964046 6.749389e-01 0.171 0 0
LDL remodeling R-HSA-8964041 6.749389e-01 0.171 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.749389e-01 0.171 0 0
Regulation of PTEN localization R-HSA-8948747 6.749389e-01 0.171 0 0
CHL1 interactions R-HSA-447041 6.749389e-01 0.171 0 0
Dual Incision in GG-NER R-HSA-5696400 6.755899e-01 0.170 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.755899e-01 0.170 0 0
Signaling by NOTCH2 R-HSA-1980145 6.755899e-01 0.170 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.755899e-01 0.170 0 0
eNOS activation R-HSA-203615 6.755899e-01 0.170 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.761735e-01 0.170 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.761735e-01 0.170 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.774792e-01 0.169 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.774792e-01 0.169 0 0
Signaling by SCF-KIT R-HSA-1433557 6.774792e-01 0.169 0 0
Signaling by FGFR4 R-HSA-5654743 6.774792e-01 0.169 0 0
Adipogenesis R-HSA-9843745 6.796605e-01 0.168 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.805524e-01 0.167 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.805524e-01 0.167 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.827509e-01 0.166 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.827509e-01 0.166 0 0
Heme assimilation R-HSA-9927020 6.827509e-01 0.166 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.827509e-01 0.166 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.827509e-01 0.166 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.827509e-01 0.166 0 0
Cellular response to starvation R-HSA-9711097 6.865360e-01 0.163 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.872302e-01 0.163 0 0
Regulation of Apoptosis R-HSA-169911 6.935302e-01 0.159 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.936079e-01 0.159 0 0
DAP12 interactions R-HSA-2172127 6.936079e-01 0.159 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.936079e-01 0.159 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.966232e-01 0.157 0 0
Metalloprotease DUBs R-HSA-5689901 6.966232e-01 0.157 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.966232e-01 0.157 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.966232e-01 0.157 0 0
Abacavir ADME R-HSA-2161522 6.966232e-01 0.157 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.966232e-01 0.157 0 0
IGF1R signaling cascade R-HSA-2428924 6.978656e-01 0.156 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.070064e-01 0.151 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.070064e-01 0.151 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.070064e-01 0.151 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.091746e-01 0.149 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.091746e-01 0.149 0 0
Nucleosome assembly R-HSA-774815 7.091746e-01 0.149 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.091746e-01 0.149 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.091746e-01 0.149 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.091746e-01 0.149 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.091746e-01 0.149 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.091746e-01 0.149 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.095009e-01 0.149 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.095009e-01 0.149 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.095009e-01 0.149 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.095009e-01 0.149 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.095009e-01 0.149 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.095009e-01 0.149 0 0
Co-stimulation by ICOS R-HSA-9927354 7.095009e-01 0.149 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.095009e-01 0.149 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.095009e-01 0.149 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.095009e-01 0.149 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.095009e-01 0.149 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.095009e-01 0.149 0 0
Adrenoceptors R-HSA-390696 7.095009e-01 0.149 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.095009e-01 0.149 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.107508e-01 0.148 0 0
Cellular response to hypoxia R-HSA-1234174 7.111073e-01 0.148 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.111073e-01 0.148 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.133308e-01 0.147 0 0
Cristae formation R-HSA-8949613 7.160782e-01 0.145 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.160782e-01 0.145 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.160782e-01 0.145 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.160782e-01 0.145 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.160782e-01 0.145 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.233892e-01 0.141 0 0
Ion homeostasis R-HSA-5578775 7.233892e-01 0.141 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 7.239548e-01 0.140 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.241771e-01 0.140 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.241771e-01 0.140 0 0
Degradation of DVL R-HSA-4641258 7.272530e-01 0.138 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.272530e-01 0.138 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.285051e-01 0.138 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.296927e-01 0.137 0 0
PKA activation in glucagon signalling R-HSA-164378 7.296927e-01 0.137 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.296927e-01 0.137 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.296927e-01 0.137 0 0
Mismatch Repair R-HSA-5358508 7.296927e-01 0.137 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.296927e-01 0.137 0 0
Platelet sensitization by LDL R-HSA-432142 7.296927e-01 0.137 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.345519e-01 0.134 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.345519e-01 0.134 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.345519e-01 0.134 0 0
Inflammasomes R-HSA-622312 7.345519e-01 0.134 0 0
IRS-mediated signalling R-HSA-112399 7.367396e-01 0.133 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.386156e-01 0.132 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.386156e-01 0.132 0 0
Synthesis of PC R-HSA-1483191 7.386156e-01 0.132 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.403899e-01 0.131 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.403899e-01 0.131 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.403899e-01 0.131 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.403899e-01 0.131 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.403899e-01 0.131 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.403899e-01 0.131 0 0
mRNA Editing R-HSA-75072 7.403899e-01 0.131 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.403899e-01 0.131 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.403899e-01 0.131 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.403899e-01 0.131 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.403899e-01 0.131 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.403899e-01 0.131 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.403899e-01 0.131 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.430416e-01 0.129 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.430416e-01 0.129 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.439639e-01 0.128 0 0
PCP/CE pathway R-HSA-4086400 7.484062e-01 0.126 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.484599e-01 0.126 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.508690e-01 0.124 0 0
Regulation of signaling by CBL R-HSA-912631 7.508690e-01 0.124 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.508690e-01 0.124 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.508690e-01 0.124 0 0
Other interleukin signaling R-HSA-449836 7.508690e-01 0.124 0 0
The NLRP3 inflammasome R-HSA-844456 7.508690e-01 0.124 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.520624e-01 0.124 0 0
Regulation of beta-cell development R-HSA-186712 7.620455e-01 0.118 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.658120e-01 0.116 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.658120e-01 0.116 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.679961e-01 0.115 0 0
DNA replication initiation R-HSA-68952 7.679961e-01 0.115 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.679961e-01 0.115 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.679961e-01 0.115 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.679961e-01 0.115 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.679961e-01 0.115 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.679961e-01 0.115 0 0
Josephin domain DUBs R-HSA-5689877 7.679961e-01 0.115 0 0
Maturation of spike protein R-HSA-9683686 7.679961e-01 0.115 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.686318e-01 0.114 0 0
Formation of definitive endoderm R-HSA-9823730 7.706001e-01 0.113 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.706001e-01 0.113 0 0
Platelet homeostasis R-HSA-418346 7.706210e-01 0.113 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.713785e-01 0.113 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.725123e-01 0.112 0 0
tRNA Aminoacylation R-HSA-379724 7.740058e-01 0.111 0 0
PI3K Cascade R-HSA-109704 7.785807e-01 0.109 0 0
Hedgehog 'on' state R-HSA-5632684 7.822470e-01 0.107 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.842857e-01 0.106 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.855096e-01 0.105 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.862178e-01 0.104 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.862178e-01 0.104 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.862178e-01 0.104 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.889536e-01 0.103 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.889536e-01 0.103 0 0
Lagging Strand Synthesis R-HSA-69186 7.889536e-01 0.103 0 0
Signalling to RAS R-HSA-167044 7.889536e-01 0.103 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.889536e-01 0.103 0 0
G1/S Transition R-HSA-69206 7.893915e-01 0.103 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.908063e-01 0.102 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.915408e-01 0.102 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.926681e-01 0.101 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.926681e-01 0.101 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.926681e-01 0.101 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.926681e-01 0.101 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.926681e-01 0.101 0 0
LGI-ADAM interactions R-HSA-5682910 7.926681e-01 0.101 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.926681e-01 0.101 0 0
Signaling by APC mutants R-HSA-4839744 7.926681e-01 0.101 0 0
vRNP Assembly R-HSA-192905 7.926681e-01 0.101 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.926681e-01 0.101 0 0
Chylomicron assembly R-HSA-8963888 7.926681e-01 0.101 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 7.926681e-01 0.101 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.926681e-01 0.101 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.926681e-01 0.101 0 0
Suppression of apoptosis R-HSA-9635465 7.926681e-01 0.101 0 0
Prostanoid ligand receptors R-HSA-391908 7.926681e-01 0.101 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.926681e-01 0.101 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.965627e-01 0.099 0 0
G0 and Early G1 R-HSA-1538133 7.990525e-01 0.097 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.990525e-01 0.097 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.992560e-01 0.097 0 0
DNA Replication R-HSA-69306 7.999621e-01 0.097 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.024981e-01 0.096 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.024981e-01 0.096 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.025741e-01 0.096 0 0
Serine metabolism R-HSA-977347 8.059995e-01 0.094 0 0
Glutathione synthesis and recycling R-HSA-174403 8.059995e-01 0.094 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.071715e-01 0.093 0 0
Selenoamino acid metabolism R-HSA-2408522 8.079091e-01 0.093 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.116434e-01 0.091 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.129625e-01 0.090 0 0
Cardiogenesis R-HSA-9733709 8.129625e-01 0.090 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.136669e-01 0.090 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.147178e-01 0.089 0 0
ERKs are inactivated R-HSA-202670 8.147178e-01 0.089 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.147178e-01 0.089 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.147178e-01 0.089 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.147178e-01 0.089 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.147178e-01 0.089 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.147178e-01 0.089 0 0
NF-kB is activated and signals survival R-HSA-209560 8.147178e-01 0.089 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.147178e-01 0.089 0 0
Signaling by AXIN mutants R-HSA-4839735 8.147178e-01 0.089 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.147178e-01 0.089 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.147178e-01 0.089 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.147178e-01 0.089 0 0
Insulin receptor signalling cascade R-HSA-74751 8.173436e-01 0.088 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.218081e-01 0.085 0 0
FGFR2 alternative splicing R-HSA-6803529 8.218081e-01 0.085 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.218081e-01 0.085 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.218081e-01 0.085 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.218081e-01 0.085 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.243242e-01 0.084 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.260476e-01 0.083 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.271079e-01 0.082 0 0
Chromosome Maintenance R-HSA-73886 8.271079e-01 0.082 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.344236e-01 0.079 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.344236e-01 0.079 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.344236e-01 0.079 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.344236e-01 0.079 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.344236e-01 0.079 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.344236e-01 0.079 0 0
Polymerase switching R-HSA-69091 8.344236e-01 0.079 0 0
Leading Strand Synthesis R-HSA-69109 8.344236e-01 0.079 0 0
Repression of WNT target genes R-HSA-4641265 8.344236e-01 0.079 0 0
MET activates RAS signaling R-HSA-8851805 8.344236e-01 0.079 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.344236e-01 0.079 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.344236e-01 0.079 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.344236e-01 0.079 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.344236e-01 0.079 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.344236e-01 0.079 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.344236e-01 0.079 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.344236e-01 0.079 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.344236e-01 0.079 0 0
OAS antiviral response R-HSA-8983711 8.344236e-01 0.079 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.344827e-01 0.079 0 0
G1 Phase R-HSA-69236 8.345392e-01 0.079 0 0
Cyclin D associated events in G1 R-HSA-69231 8.345392e-01 0.079 0 0
Proteasome assembly R-HSA-9907900 8.345392e-01 0.079 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.364499e-01 0.078 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.364499e-01 0.078 0 0
Interleukin-20 family signaling R-HSA-8854691 8.364499e-01 0.078 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.364499e-01 0.078 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.364499e-01 0.078 0 0
Carnitine shuttle R-HSA-200425 8.364499e-01 0.078 0 0
Syndecan interactions R-HSA-3000170 8.364499e-01 0.078 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.368212e-01 0.077 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.383409e-01 0.077 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.383409e-01 0.077 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.383409e-01 0.077 0 0
Gap junction assembly R-HSA-190861 8.383409e-01 0.077 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.394541e-01 0.076 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.409163e-01 0.075 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.409722e-01 0.075 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.441557e-01 0.074 0 0
Signaling by FGFR1 R-HSA-5654736 8.441557e-01 0.074 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.441557e-01 0.074 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.444250e-01 0.073 0 0
Somitogenesis R-HSA-9824272 8.450867e-01 0.073 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.454774e-01 0.073 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.491594e-01 0.071 0 0
Oncogene Induced Senescence R-HSA-2559585 8.498761e-01 0.071 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.498761e-01 0.071 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.498761e-01 0.071 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.498761e-01 0.071 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.499940e-01 0.071 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.499940e-01 0.071 0 0
Interleukin-6 family signaling R-HSA-6783589 8.499940e-01 0.071 0 0
tRNA processing R-HSA-72306 8.502968e-01 0.070 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.520346e-01 0.070 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.520346e-01 0.070 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.520346e-01 0.070 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.520346e-01 0.070 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.524926e-01 0.069 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.533573e-01 0.069 0 0
Regulated Necrosis R-HSA-5218859 8.538429e-01 0.069 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.550612e-01 0.068 0 0
Gene Silencing by RNA R-HSA-211000 8.581170e-01 0.066 0 0
ER-Phagosome pathway R-HSA-1236974 8.581917e-01 0.066 0 0
FLT3 signaling in disease R-HSA-9682385 8.606874e-01 0.065 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.606874e-01 0.065 0 0
GPVI-mediated activation cascade R-HSA-114604 8.606874e-01 0.065 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.608283e-01 0.065 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.612463e-01 0.065 0 0
Signaling by FGFR R-HSA-190236 8.612463e-01 0.065 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.612463e-01 0.065 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.612463e-01 0.065 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.612463e-01 0.065 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.621018e-01 0.064 0 0
Dual incision in TC-NER R-HSA-6782135 8.621018e-01 0.064 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.625084e-01 0.064 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.625084e-01 0.064 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.625084e-01 0.064 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.625084e-01 0.064 0 0
Signaling by FGFR2 R-HSA-5654738 8.631973e-01 0.064 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.644840e-01 0.063 0 0
Base Excision Repair R-HSA-73884 8.652724e-01 0.063 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.677735e-01 0.062 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.677735e-01 0.062 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.677735e-01 0.062 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.677735e-01 0.062 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.677735e-01 0.062 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.677735e-01 0.062 0 0
cGMP effects R-HSA-418457 8.677735e-01 0.062 0 0
Physiological factors R-HSA-5578768 8.677735e-01 0.062 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.677735e-01 0.062 0 0
Ciprofloxacin ADME R-HSA-9793528 8.677735e-01 0.062 0 0
Mitochondrial biogenesis R-HSA-1592230 8.681144e-01 0.061 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.691631e-01 0.061 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.697198e-01 0.061 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.697198e-01 0.061 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.704043e-01 0.060 0 0
Extension of Telomeres R-HSA-180786 8.704043e-01 0.060 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.708089e-01 0.060 0 0
Degradation of AXIN R-HSA-4641257 8.708089e-01 0.060 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.708089e-01 0.060 0 0
Collagen chain trimerization R-HSA-8948216 8.708089e-01 0.060 0 0
Platelet degranulation R-HSA-114608 8.717202e-01 0.060 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.720630e-01 0.059 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.740588e-01 0.058 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.740588e-01 0.058 0 0
TRP channels R-HSA-3295583 8.740588e-01 0.058 0 0
ABC-family proteins mediated transport R-HSA-382556 8.742631e-01 0.058 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.768405e-01 0.057 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.768405e-01 0.057 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.771034e-01 0.057 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.771034e-01 0.057 0 0
MET promotes cell motility R-HSA-8875878 8.802745e-01 0.055 0 0
DNA Damage Bypass R-HSA-73893 8.817604e-01 0.055 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.818390e-01 0.055 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.818390e-01 0.055 0 0
Protein lipoylation R-HSA-9857492 8.818390e-01 0.055 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.818390e-01 0.055 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.818390e-01 0.055 0 0
Translesion synthesis by REV1 R-HSA-110312 8.818390e-01 0.055 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.818390e-01 0.055 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.818390e-01 0.055 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.818390e-01 0.055 0 0
p38MAPK events R-HSA-171007 8.818390e-01 0.055 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.818390e-01 0.055 0 0
DNA Damage Reversal R-HSA-73942 8.818390e-01 0.055 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.841323e-01 0.053 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.847086e-01 0.053 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.847086e-01 0.053 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.847086e-01 0.053 0 0
Insulin processing R-HSA-264876 8.847086e-01 0.053 0 0
Triglyceride biosynthesis R-HSA-75109 8.847086e-01 0.053 0 0
Synthesis of PE R-HSA-1483213 8.847086e-01 0.053 0 0
Signaling by Insulin receptor R-HSA-74752 8.848031e-01 0.053 0 0
MAP kinase activation R-HSA-450294 8.857439e-01 0.053 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.857439e-01 0.053 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.857439e-01 0.053 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.891177e-01 0.051 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.891177e-01 0.051 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.891177e-01 0.051 0 0
Mitochondrial protein import R-HSA-1268020 8.928117e-01 0.049 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.928117e-01 0.049 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.935079e-01 0.049 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.944091e-01 0.048 0 0
Translesion synthesis by POLI R-HSA-5656121 8.944091e-01 0.048 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.944091e-01 0.048 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.944091e-01 0.048 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.944091e-01 0.048 0 0
Activation of SMO R-HSA-5635838 8.944091e-01 0.048 0 0
Fructose catabolism R-HSA-70350 8.944091e-01 0.048 0 0
Differentiation of T cells R-HSA-9945266 8.944091e-01 0.048 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.944091e-01 0.048 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.944091e-01 0.048 0 0
Attachment and Entry R-HSA-9678110 8.944091e-01 0.048 0 0
Atorvastatin ADME R-HSA-9754706 8.944091e-01 0.048 0 0
Telomere Extension By Telomerase R-HSA-171319 8.945187e-01 0.048 0 0
Insulin receptor recycling R-HSA-77387 8.945187e-01 0.048 0 0
Pyrimidine salvage R-HSA-73614 8.945187e-01 0.048 0 0
Pyroptosis R-HSA-5620971 8.945187e-01 0.048 0 0
Co-inhibition by PD-1 R-HSA-389948 8.962767e-01 0.048 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.970884e-01 0.047 0 0
The phototransduction cascade R-HSA-2514856 8.970884e-01 0.047 0 0
Glycogen metabolism R-HSA-8982491 8.973714e-01 0.047 0 0
Tryptophan catabolism R-HSA-71240 8.973714e-01 0.047 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.019241e-01 0.045 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.024876e-01 0.045 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.024876e-01 0.045 0 0
Iron uptake and transport R-HSA-917937 9.032085e-01 0.044 0 0
mRNA Capping R-HSA-72086 9.035471e-01 0.044 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.035471e-01 0.044 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.035471e-01 0.044 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.035471e-01 0.044 0 0
Platelet calcium homeostasis R-HSA-418360 9.035471e-01 0.044 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.040754e-01 0.044 0 0
Maturation of spike protein R-HSA-9694548 9.050677e-01 0.043 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.050677e-01 0.043 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.056426e-01 0.043 0 0
Translesion synthesis by POLK R-HSA-5655862 9.056426e-01 0.043 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.056426e-01 0.043 0 0
Glycine degradation R-HSA-6783984 9.056426e-01 0.043 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.056426e-01 0.043 0 0
Passive transport by Aquaporins R-HSA-432047 9.056426e-01 0.043 0 0
Synthesis of PG R-HSA-1483148 9.056426e-01 0.043 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.056426e-01 0.043 0 0
Signaling by Interleukins R-HSA-449147 9.102224e-01 0.041 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.118492e-01 0.040 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.118492e-01 0.040 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.118492e-01 0.040 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.118492e-01 0.040 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.121021e-01 0.040 0 0
Potassium Channels R-HSA-1296071 9.121021e-01 0.040 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.122379e-01 0.040 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.122379e-01 0.040 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.122379e-01 0.040 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.122379e-01 0.040 0 0
Translation of Structural Proteins R-HSA-9683701 9.122379e-01 0.040 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.137664e-01 0.039 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.137664e-01 0.039 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.137664e-01 0.039 0 0
Translation of Structural Proteins R-HSA-9694635 9.143684e-01 0.039 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.146207e-01 0.039 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.156816e-01 0.038 0 0
Glycogen storage diseases R-HSA-3229121 9.156816e-01 0.038 0 0
Catecholamine biosynthesis R-HSA-209905 9.156816e-01 0.038 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.156816e-01 0.038 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.156816e-01 0.038 0 0
Choline catabolism R-HSA-6798163 9.156816e-01 0.038 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.156816e-01 0.038 0 0
HCMV Early Events R-HSA-9609690 9.189024e-01 0.037 0 0
Budding and maturation of HIV virion R-HSA-162588 9.194771e-01 0.036 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.210512e-01 0.036 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.227456e-01 0.035 0 0
Nephron development R-HSA-9831926 9.246530e-01 0.034 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.246530e-01 0.034 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.246530e-01 0.034 0 0
Tie2 Signaling R-HSA-210993 9.246530e-01 0.034 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.246530e-01 0.034 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.246530e-01 0.034 0 0
GAB1 signalosome R-HSA-180292 9.246530e-01 0.034 0 0
Defective pyroptosis R-HSA-9710421 9.251197e-01 0.034 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.251197e-01 0.034 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.251892e-01 0.034 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.264804e-01 0.033 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.268586e-01 0.033 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.277564e-01 0.033 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.290306e-01 0.032 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.290306e-01 0.032 0 0
TCR signaling R-HSA-202403 9.291392e-01 0.032 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.308885e-01 0.031 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.326704e-01 0.030 0 0
Pyrimidine biosynthesis R-HSA-500753 9.326704e-01 0.030 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.326704e-01 0.030 0 0
Diseases of hemostasis R-HSA-9671793 9.326704e-01 0.030 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.326704e-01 0.030 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.329056e-01 0.030 0 0
Nuclear RNA decay R-HSA-9930044 9.329056e-01 0.030 0 0
Reproduction R-HSA-1474165 9.361511e-01 0.029 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.362457e-01 0.029 0 0
Leishmania phagocytosis R-HSA-9664417 9.364798e-01 0.029 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.364798e-01 0.029 0 0
Parasite infection R-HSA-9664407 9.364798e-01 0.029 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.369175e-01 0.028 0 0
Interleukin-17 signaling R-HSA-448424 9.369175e-01 0.028 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.374934e-01 0.028 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.381474e-01 0.028 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.387964e-01 0.027 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.387964e-01 0.027 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.387964e-01 0.027 0 0
Heme degradation R-HSA-189483 9.387964e-01 0.027 0 0
Cardiac conduction R-HSA-5576891 9.393479e-01 0.027 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.394406e-01 0.027 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.394406e-01 0.027 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.398350e-01 0.027 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.398350e-01 0.027 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.398350e-01 0.027 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.398350e-01 0.027 0 0
Glycogen synthesis R-HSA-3322077 9.398350e-01 0.027 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.398350e-01 0.027 0 0
Creatine metabolism R-HSA-71288 9.398350e-01 0.027 0 0
Pregnenolone biosynthesis R-HSA-196108 9.398350e-01 0.027 0 0
Signal transduction by L1 R-HSA-445144 9.398350e-01 0.027 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.398350e-01 0.027 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.399252e-01 0.027 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.422463e-01 0.026 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.422463e-01 0.026 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.441937e-01 0.025 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.441937e-01 0.025 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.441937e-01 0.025 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.450220e-01 0.025 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.458265e-01 0.024 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.459865e-01 0.024 0 0
Mitochondrial protein degradation R-HSA-9837999 9.459865e-01 0.024 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.462377e-01 0.024 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.462377e-01 0.024 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.462377e-01 0.024 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.462377e-01 0.024 0 0
Abacavir metabolism R-HSA-2161541 9.462377e-01 0.024 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.462922e-01 0.024 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.463928e-01 0.024 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.491358e-01 0.023 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.491358e-01 0.023 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.491358e-01 0.023 0 0
Metal ion SLC transporters R-HSA-425410 9.500981e-01 0.022 0 0
Collagen degradation R-HSA-1442490 9.502650e-01 0.022 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.518069e-01 0.021 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.519593e-01 0.021 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.519593e-01 0.021 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.519593e-01 0.021 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.519593e-01 0.021 0 0
Ribavirin ADME R-HSA-9755088 9.519593e-01 0.021 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.519593e-01 0.021 0 0
Attachment and Entry R-HSA-9694614 9.519593e-01 0.021 0 0
Leishmania infection R-HSA-9658195 9.525580e-01 0.021 0 0
Parasitic Infection Pathways R-HSA-9824443 9.525580e-01 0.021 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.536585e-01 0.021 0 0
Glycosphingolipid transport R-HSA-9845576 9.536585e-01 0.021 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.537682e-01 0.021 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.538786e-01 0.021 0 0
Transmission across Chemical Synapses R-HSA-112315 9.539537e-01 0.020 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.570723e-01 0.019 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.570723e-01 0.019 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.570723e-01 0.019 0 0
Fructose metabolism R-HSA-5652084 9.570723e-01 0.019 0 0
Ethanol oxidation R-HSA-71384 9.570723e-01 0.019 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.570723e-01 0.019 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.570723e-01 0.019 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 9.570723e-01 0.019 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.575952e-01 0.019 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.577148e-01 0.019 0 0
Telomere Maintenance R-HSA-157579 9.579376e-01 0.019 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.580763e-01 0.019 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.586277e-01 0.018 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.598792e-01 0.018 0 0
Ion transport by P-type ATPases R-HSA-936837 9.603904e-01 0.018 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.603904e-01 0.018 0 0
Meiotic recombination R-HSA-912446 9.611007e-01 0.017 0 0
Complex IV assembly R-HSA-9864848 9.611007e-01 0.017 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.616414e-01 0.017 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.616414e-01 0.017 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.616414e-01 0.017 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.616414e-01 0.017 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.616414e-01 0.017 0 0
Gastrulation R-HSA-9758941 9.619377e-01 0.017 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.631029e-01 0.016 0 0
ABC transporter disorders R-HSA-5619084 9.639952e-01 0.016 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.642306e-01 0.016 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.657244e-01 0.015 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.657244e-01 0.015 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.657244e-01 0.015 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.657244e-01 0.015 0 0
Complex III assembly R-HSA-9865881 9.657244e-01 0.015 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.657244e-01 0.015 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.657244e-01 0.015 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.671220e-01 0.015 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.681860e-01 0.014 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.681860e-01 0.014 0 0
Diseases of Immune System R-HSA-5260271 9.681860e-01 0.014 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.681860e-01 0.014 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.693731e-01 0.014 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.693731e-01 0.014 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.693731e-01 0.014 0 0
Hyaluronan degradation R-HSA-2160916 9.693731e-01 0.014 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.693731e-01 0.014 0 0
Laminin interactions R-HSA-3000157 9.693731e-01 0.014 0 0
PI Metabolism R-HSA-1483255 9.694998e-01 0.013 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.697917e-01 0.013 0 0
HCMV Infection R-HSA-9609646 9.699598e-01 0.013 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.699960e-01 0.013 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.710657e-01 0.013 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.719180e-01 0.012 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.719180e-01 0.012 0 0
Paracetamol ADME R-HSA-9753281 9.722553e-01 0.012 0 0
MET activates PTK2 signaling R-HSA-8874081 9.726335e-01 0.012 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.726335e-01 0.012 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.726335e-01 0.012 0 0
Urea cycle R-HSA-70635 9.726335e-01 0.012 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.726335e-01 0.012 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.736931e-01 0.012 0 0
Heme biosynthesis R-HSA-189451 9.736931e-01 0.012 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.737971e-01 0.012 0 0
RSV-host interactions R-HSA-9833110 9.749609e-01 0.011 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.755470e-01 0.011 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.755470e-01 0.011 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.755470e-01 0.011 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.755470e-01 0.011 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.755470e-01 0.011 0 0
Collagen formation R-HSA-1474290 9.755594e-01 0.011 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.760892e-01 0.011 0 0
Depyrimidination R-HSA-73928 9.760892e-01 0.011 0 0
Toll-like Receptor Cascades R-HSA-168898 9.767900e-01 0.010 0 0
Metabolism of cofactors R-HSA-8978934 9.770504e-01 0.010 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.781504e-01 0.010 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.781504e-01 0.010 0 0
Prednisone ADME R-HSA-9757110 9.781504e-01 0.010 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.788045e-01 0.009 0 0
G alpha (s) signalling events R-HSA-418555 9.797290e-01 0.009 0 0
Neuronal System R-HSA-112316 9.798089e-01 0.009 0 0
Triglyceride metabolism R-HSA-8979227 9.803302e-01 0.009 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.804769e-01 0.009 0 0
DNA methylation R-HSA-5334118 9.804769e-01 0.009 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.804769e-01 0.009 0 0
Infectious disease R-HSA-5663205 9.812571e-01 0.008 0 0
Developmental Biology R-HSA-1266738 9.813708e-01 0.008 0 0
RAB geranylgeranylation R-HSA-8873719 9.819667e-01 0.008 0 0
Metabolism of polyamines R-HSA-351202 9.819667e-01 0.008 0 0
Neurotransmitter clearance R-HSA-112311 9.825557e-01 0.008 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.833383e-01 0.007 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.837277e-01 0.007 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.837277e-01 0.007 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.837277e-01 0.007 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.844133e-01 0.007 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.844133e-01 0.007 0 0
Cargo concentration in the ER R-HSA-5694530 9.844133e-01 0.007 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.844133e-01 0.007 0 0
SLC transporter disorders R-HSA-5619102 9.859850e-01 0.006 0 0
Signaling by WNT in cancer R-HSA-4791275 9.860732e-01 0.006 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.860732e-01 0.006 0 0
DAG1 glycosylations R-HSA-8931838 9.860732e-01 0.006 0 0
Interleukin-1 signaling R-HSA-9020702 9.861726e-01 0.006 0 0
Downstream TCR signaling R-HSA-202424 9.862933e-01 0.006 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.869424e-01 0.006 0 0
Cholesterol biosynthesis R-HSA-191273 9.869424e-01 0.006 0 0
Integrin cell surface interactions R-HSA-216083 9.869424e-01 0.006 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.888817e-01 0.005 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.888817e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.888817e-01 0.005 0 0
Amyloid fiber formation R-HSA-977225 9.897964e-01 0.004 0 0
Mitophagy R-HSA-5205647 9.900659e-01 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 9.900659e-01 0.004 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.900659e-01 0.004 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.900659e-01 0.004 0 0
Developmental Cell Lineages R-HSA-9734767 9.902623e-01 0.004 0 0
Adaptive Immune System R-HSA-1280218 9.910688e-01 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.911241e-01 0.004 0 0
PERK regulates gene expression R-HSA-381042 9.911241e-01 0.004 0 0
Nucleotide biosynthesis R-HSA-8956320 9.917829e-01 0.004 0 0
Neddylation R-HSA-8951664 9.918322e-01 0.004 0 0
Interleukin-1 family signaling R-HSA-446652 9.918693e-01 0.004 0 0
G1/S-Specific Transcription R-HSA-69205 9.920696e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.920696e-01 0.003 0 0
Triglyceride catabolism R-HSA-163560 9.920696e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.920696e-01 0.003 0 0
Stimuli-sensing channels R-HSA-2672351 9.923365e-01 0.003 0 0
COPII-mediated vesicle transport R-HSA-204005 9.925623e-01 0.003 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.926456e-01 0.003 0 0
Hemostasis R-HSA-109582 9.928705e-01 0.003 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.929144e-01 0.003 0 0
Cleavage of the damaged purine R-HSA-110331 9.929144e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.929144e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.929144e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.932032e-01 0.003 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.936693e-01 0.003 0 0
Depurination R-HSA-73927 9.936693e-01 0.003 0 0
Elastic fibre formation R-HSA-1566948 9.936693e-01 0.003 0 0
Purine salvage R-HSA-74217 9.936693e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.938193e-01 0.003 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.943438e-01 0.002 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.943438e-01 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.949465e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.949465e-01 0.002 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.952723e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.954633e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.954850e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.954850e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.958936e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.962838e-01 0.002 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.963373e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.963960e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.964081e-01 0.002 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.967801e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.967801e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.969063e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.971233e-01 0.001 0 0
Methylation R-HSA-156581 9.971233e-01 0.001 0 0
Amine ligand-binding receptors R-HSA-375280 9.971233e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.971233e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.972821e-01 0.001 0 0
HCMV Late Events R-HSA-9610379 9.975188e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.977038e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.977378e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.981283e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.981283e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.981524e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.981673e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.983627e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.983627e-01 0.001 0 0
Ion channel transport R-HSA-983712 9.984910e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.985373e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.986397e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.986427e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.986427e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.986932e-01 0.001 0 0
Protein localization R-HSA-9609507 9.987377e-01 0.001 0 0
Purine catabolism R-HSA-74259 9.987737e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.988922e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.989138e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.989315e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.990661e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.991496e-01 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.991591e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.992564e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.993997e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.994362e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.995061e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.995110e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.995574e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996624e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.996925e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.997340e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997458e-01 0.000 0 0
Kidney development R-HSA-9830369 9.997851e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997851e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998314e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998375e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.998401e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998632e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998632e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999025e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999159e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999242e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999385e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999425e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999482e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999519e-01 0.000 0 0
Immune System R-HSA-168256 9.999528e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999567e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999665e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999676e-01 0.000 0 0
Disease R-HSA-1643685 9.999749e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999781e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999799e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999822e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999826e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999847e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999854e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999868e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999902e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999913e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999915e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999925e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999942e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999956e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999957e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999959e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999960e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999968e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999978e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999978e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999989e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999989e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999991e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999994e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999998e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999998e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999998e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999998e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways