BRSK1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
A6NKT7	S980	Sugiyama	RGPD3 RGP3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O14639	S452	Sugiyama	ABLIM1 ABLIM KIAA0059 LIMAB1	PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14715	S979	Sugiyama	RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O43423	S100	Sugiyama	ANP32CP PP32R1	AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43707	T445	Sugiyama	ACTN4	HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841	S190	Sugiyama	EIF5B IF2 KIAA0741	NsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGP
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95626	S104	Sugiyama	ANP32D PP32R2	AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07737	S28	Sugiyama	PFN1	IDNLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEV
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P09132	S69	Sugiyama	SRP19	IQDVCSAVGLNVFLEKNKMYsREWNRDVQYRGRVRVQLKQE
P0DJD0	S964	Sugiyama	RGPD1 RANBP2L6 RGP1	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10636	S579	GPS6\|EPSD	MAPT MAPTL MTBT1 TAU	RLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQIINKKL
P10809	T428	Sugiyama	HSPD1 HSP60	GtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGCALLRCI
P12004	S172	Sugiyama	PCNA	sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P13797	S540	Sugiyama	PLS3	NDDIIVNWVNRTLSEAGKSTsIQSFKDKTISSSLAVVDLID
P13798	S185	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	VAEKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQ
P14625	T171	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P16949	S46	Sugiyama	STMN1 C1orf215 LAP18 OP18	PRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAEERRKsHEA
P20810	S45	SIGNOR	CAST	KHKKQAVKTEPEKKSQsTKLsVVHEKKSQEGKPKEHTEPKS
P23258	S131	SIGNOR\|EPSD\|PSP	TUBG1 TUBG	GEKIHEDIFDIIDREADGSDsLEGFVLCHSIAGGTGSGLGS
P23258	S385	EPSD\|PSP	TUBG1 TUBG	PYLPSAHRVSGLMMANHTSIsSLFERTCRQYDKLRKREAFL
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P30291	S642	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	WEE1	STTQSNRTSRLIGKKMNRSVsLTIY________________
P30305	S375	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDC25B CDC25HU2	tPPEEQQEAEEPKARVLRsKsLCHDEIENLLDSDHRELIGD
P30307	S216	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDC25C	EFsLKDQEAKVSRsGLYRsPsMPENLNRPRLKQVEKFKDNt
P39687	S104	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P49792	S1955	Sugiyama	RANBP2 NUP358	GVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSGAG
P49840	Y279	Sugiyama	GSK3A	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841	Y216	Sugiyama	GSK3B	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P54105	S198	Sugiyama	CLNS1A CLCI ICLN	TAEGQATLERLEGMLsQsVssQYNMAGVRtEDsIRDyEDGM
P68363	S439	Sugiyama	TUBA1B	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q08AD1	S1313	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q08AD1	S464	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q13131	T183	EPSD\|PSP	PRKAA1 AMPK1	NAKIADFGLsNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
Q13464	S576	Sugiyama	ROCK1	TESDTAVRLRKSHTEMSKSIsQLESLNRELQERNRILENSK
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q15293	S80	Sugiyama	RCN1 RCN	HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q5H9R7	S579	Sugiyama	PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3	IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36	S439	Sugiyama	TUBA1A TUBA3	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q7Z3J3	S980	Sugiyama	RGPD4 RGP4	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
Q7Z460	S545	Sugiyama	CLASP1 KIAA0622 MAST1	yHTLESSyQKALQSHLKNSDsIVsLPQsDRsssssQEsLNR
Q8WWI1	T932	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	VtPRPFGsQtRGISsLPRsYtMDDAWKYNGDVEDIKRtPNN
Q93045	S80	Sugiyama	STMN2 SCG10 SCGN10	PPsPISEAPRTLAsPKKKDLsLEEIQKKLEAAEERRKsQEA
Q96HE7	S143	Sugiyama	ERO1A ERO1L UNQ434/PRO865	EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96L92	S51	Sugiyama	SNX27 KIAA0488 My014	AGNGGGGGGGPRVVRIVKsEsGYGFNVRGQVsEGGQLRSIN
Q99666	S979	Sugiyama	RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9NVR5	S773	Sugiyama	DNAAF2 C14orf104 KTU	EFIKEKSATCSNEEKDNLNEsVITEEKETDGDHLsSLLNKT
Q9P1Y5	S431	Sugiyama	CAMSAP3 KIAA1543	FGLDSDVDVVMGDPVLLRsVssDsLGPPRPAPARTPtQPPP

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Signal Transduction	R-HSA-162582	1.930519e-07	6.714
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	7.920828e-06	5.101
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.441361e-05	4.841
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.915237e-05	4.718
Intracellular signaling by second messengers	R-HSA-9006925	2.263669e-05	4.645
Apoptotic execution phase	R-HSA-75153	3.822989e-05	4.418
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.944088e-05	4.226
Regulation of TP53 Activity	R-HSA-5633007	6.729356e-05	4.172
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.043866e-04	3.981
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.064953e-04	3.973
PIP3 activates AKT signaling	R-HSA-1257604	1.073603e-04	3.969
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.970164e-04	3.705
Regulation of PTEN localization	R-HSA-8948747	2.274214e-04	3.643
Apoptosis	R-HSA-109581	3.296838e-04	3.482
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.827879e-04	3.417
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.777528e-04	3.423
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.827879e-04	3.417
Programmed Cell Death	R-HSA-5357801	3.578287e-04	3.446
Cell Cycle	R-HSA-1640170	4.863009e-04	3.313
Centrosome maturation	R-HSA-380287	5.260814e-04	3.279
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.657950e-04	3.177
Mitotic Prometaphase	R-HSA-68877	6.363551e-04	3.196
Mitotic G2-G2/M phases	R-HSA-453274	7.253576e-04	3.139
Transcriptional Regulation by TP53	R-HSA-3700989	7.449217e-04	3.128
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	8.283420e-04	3.082
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.547487e-04	3.068
Regulation of necroptotic cell death	R-HSA-5675482	9.788270e-04	3.009
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.456608e-03	2.837
FLT3 signaling by CBL mutants	R-HSA-9706377	1.625931e-03	2.789
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.596139e-03	2.797
Regulation of PTEN gene transcription	R-HSA-8943724	1.630757e-03	2.788
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.601629e-03	2.795
Axon guidance	R-HSA-422475	1.726702e-03	2.763
Cell Cycle Checkpoints	R-HSA-69620	1.827613e-03	2.738
Death Receptor Signaling	R-HSA-73887	1.820304e-03	2.740
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.846126e-03	2.734
G alpha (12/13) signalling events	R-HSA-416482	1.861673e-03	2.730
G2/M Transition	R-HSA-69275	1.904651e-03	2.720
Spry regulation of FGF signaling	R-HSA-1295596	2.221960e-03	2.653
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.221960e-03	2.653
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.319745e-03	2.635
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.319745e-03	2.635
NRAGE signals death through JNK	R-HSA-193648	2.085341e-03	2.681
Chaperone Mediated Autophagy	R-HSA-9613829	1.981836e-03	2.703
FLT3 Signaling	R-HSA-9607240	2.183936e-03	2.661
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.219489e-03	2.654
FLT3 signaling in disease	R-HSA-9682385	2.280188e-03	2.642
Cell Cycle, Mitotic	R-HSA-69278	2.363971e-03	2.626
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.622959e-03	2.581
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.418170e-03	2.466
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.418170e-03	2.466
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.418170e-03	2.466
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.418170e-03	2.466
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.391456e-03	2.357
Late endosomal microautophagy	R-HSA-9615710	3.596796e-03	2.444
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	3.596796e-03	2.444
Impaired BRCA2 binding to RAD51	R-HSA-9709570	3.596796e-03	2.444
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	4.237786e-03	2.373
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	4.237786e-03	2.373
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.992212e-03	2.399
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.567249e-03	2.591
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.567249e-03	2.591
AURKA Activation by TPX2	R-HSA-8854518	3.916098e-03	2.407
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.532545e-03	2.452
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.455100e-03	2.351
Neurodegenerative Diseases	R-HSA-8863678	3.587140e-03	2.445
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.587140e-03	2.445
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	4.039573e-03	2.394
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.333635e-03	2.477
Resolution of D-Loop Structures	R-HSA-5693537	3.499285e-03	2.456
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.292671e-03	2.482
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.868220e-03	2.542
DNA Double-Strand Break Repair	R-HSA-5693532	2.986543e-03	2.525
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.382277e-03	2.358
Ovarian tumor domain proteases	R-HSA-5689896	2.766177e-03	2.558
Post NMDA receptor activation events	R-HSA-438064	3.134925e-03	2.504
NGF-stimulated transcription	R-HSA-9031628	3.418192e-03	2.466
Transcriptional Regulation by E2F6	R-HSA-8953750	3.992212e-03	2.399
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.390700e-03	2.470
MAP kinase activation	R-HSA-450294	4.381790e-03	2.358
AKT phosphorylates targets in the cytosol	R-HSA-198323	3.337847e-03	2.477
Negative regulation of FLT3	R-HSA-9706369	3.025824e-03	2.519
p75 NTR receptor-mediated signalling	R-HSA-193704	3.846005e-03	2.415
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.752122e-03	2.323
Signaling by EGFR	R-HSA-177929	4.889059e-03	2.311
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.096236e-03	2.293
Josephin domain DUBs	R-HSA-5689877	4.969127e-03	2.304
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.969127e-03	2.304
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.964856e-03	2.304
Regulated Necrosis	R-HSA-5218859	5.105791e-03	2.292
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.133315e-03	2.290
Signaling by ALK in cancer	R-HSA-9700206	5.133315e-03	2.290
Homology Directed Repair	R-HSA-5693538	5.273198e-03	2.278
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.568133e-03	2.254
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.568133e-03	2.254
Transcriptional activation of p53 responsive genes	R-HSA-69560	6.002034e-03	2.222
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	6.002034e-03	2.222
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	6.002034e-03	2.222
RET signaling	R-HSA-8853659	6.087761e-03	2.216
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.262888e-03	2.203
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.832947e-03	2.165
MyD88-independent TLR4 cascade	R-HSA-166166	6.900465e-03	2.161
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.900465e-03	2.161
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.703975e-03	2.174
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.703975e-03	2.174
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.703975e-03	2.174
Nervous system development	R-HSA-9675108	6.698339e-03	2.174
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.505570e-03	2.187
Cellular response to heat stress	R-HSA-3371556	6.971459e-03	2.157
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.029457e-03	2.153
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	7.030581e-03	2.153
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.804178e-03	2.108
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.804178e-03	2.108
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.898439e-03	2.102
Mitotic Spindle Checkpoint	R-HSA-69618	8.200355e-03	2.086
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.242527e-03	2.084
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.302145e-03	2.081
DNA Damage Recognition in GG-NER	R-HSA-5696394	9.295819e-03	2.032
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.525193e-03	2.069
Macroautophagy	R-HSA-1632852	9.212791e-03	2.036
Chromatin modifying enzymes	R-HSA-3247509	9.301996e-03	2.031
DNA Double Strand Break Response	R-HSA-5693606	9.526338e-03	2.021
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	9.646111e-03	2.016
Mitotic Telophase/Cytokinesis	R-HSA-68884	9.646111e-03	2.016
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.063132e-02	1.973
Myoclonic epilepsy of Lafora	R-HSA-3785653	1.063132e-02	1.973
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.001070e-02	2.000
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.002975e-02	1.999
Amplification of signal from the kinetochores	R-HSA-141424	1.002975e-02	1.999
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.000801e-02	2.000
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.068841e-02	1.971
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	9.958489e-03	2.002
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.047486e-02	1.980
Downregulation of ERBB4 signaling	R-HSA-1253288	1.063132e-02	1.973
Regulation of NF-kappa B signaling	R-HSA-9758274	1.068841e-02	1.971
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.088559e-02	1.963
Aggrephagy	R-HSA-9646399	1.166454e-02	1.933
TNF signaling	R-HSA-75893	1.084362e-02	1.965
Processing of DNA double-strand break ends	R-HSA-5693607	1.147963e-02	1.940
Negative regulation of MET activity	R-HSA-6807004	1.088559e-02	1.963
Signaling by ROBO receptors	R-HSA-376176	1.116525e-02	1.952
Autophagy	R-HSA-9612973	1.122035e-02	1.950
Nephrin family interactions	R-HSA-373753	1.088559e-02	1.963
Interleukin-37 signaling	R-HSA-9008059	1.197460e-02	1.922
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.200967e-02	1.920
IRAK1 recruits IKK complex	R-HSA-937039	1.289127e-02	1.890
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.289127e-02	1.890
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.362255e-02	1.866
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.362255e-02	1.866
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.284671e-02	1.891
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.347486e-02	1.870
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.347486e-02	1.870
p75NTR recruits signalling complexes	R-HSA-209543	1.289127e-02	1.890
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.289127e-02	1.890
HSF1-dependent transactivation	R-HSA-3371571	1.227203e-02	1.911
M Phase	R-HSA-68886	1.252700e-02	1.902
Long-term potentiation	R-HSA-9620244	1.284671e-02	1.891
HDMs demethylate histones	R-HSA-3214842	1.284671e-02	1.891
Interleukin-17 signaling	R-HSA-448424	1.348428e-02	1.870
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.289127e-02	1.890
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.289127e-02	1.890
Diseases of DNA repair	R-HSA-9675135	1.386405e-02	1.858
EGFR downregulation	R-HSA-182971	1.421592e-02	1.847
Evasion by RSV of host interferon responses	R-HSA-9833109	1.421592e-02	1.847
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.494140e-02	1.826
Metalloprotease DUBs	R-HSA-5689901	1.544742e-02	1.811
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.544742e-02	1.811
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.579432e-02	1.801
Maturation of protein E	R-HSA-9694493	1.579432e-02	1.801
Maturation of protein E	R-HSA-9683683	1.579432e-02	1.801
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.648706e-02	1.783
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.648706e-02	1.783
Signaling by Hippo	R-HSA-2028269	1.709254e-02	1.767
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.692110e-02	1.772
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.811003e-02	1.742
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.811003e-02	1.742
Signaling by NTRKs	R-HSA-166520	1.692110e-02	1.772
Membrane Trafficking	R-HSA-199991	1.954189e-02	1.709
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.961833e-02	1.707
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.961833e-02	1.707
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.961833e-02	1.707
Signaling by FGFR2	R-HSA-5654738	1.983413e-02	1.703
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.995651e-02	1.700
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.025287e-02	1.694
Pexophagy	R-HSA-9664873	2.028671e-02	1.693
Tandem pore domain potassium channels	R-HSA-1296346	2.028671e-02	1.693
Signaling by FGFR4	R-HSA-5654743	2.052608e-02	1.688
Signaling by ERBB4	R-HSA-1236394	2.064054e-02	1.685
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.114332e-02	1.675
Polo-like kinase mediated events	R-HSA-156711	2.114332e-02	1.675
NRIF signals cell death from the nucleus	R-HSA-205043	2.153383e-02	1.667
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.388816e-02	1.622
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.388816e-02	1.622
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.310004e-02	1.636
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.391582e-02	1.621
mRNA Splicing - Major Pathway	R-HSA-72163	2.368995e-02	1.625
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.555733e-02	1.592
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.330013e-02	1.633
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.555733e-02	1.592
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.287149e-02	1.641
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.287149e-02	1.641
Cellular Senescence	R-HSA-2559583	2.388955e-02	1.622
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.320220e-02	1.634
Chromatin organization	R-HSA-4839726	2.212673e-02	1.655
Heme signaling	R-HSA-9707616	2.210061e-02	1.656
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.269329e-02	1.644
ISG15 antiviral mechanism	R-HSA-1169408	2.281560e-02	1.642
PTEN Regulation	R-HSA-6807070	2.205768e-02	1.656
Germ layer formation at gastrulation	R-HSA-9754189	2.581639e-02	1.588
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.581639e-02	1.588
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.581639e-02	1.588
Rab regulation of trafficking	R-HSA-9007101	2.620031e-02	1.582
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.627001e-02	1.581
Negative regulation of FGFR2 signaling	R-HSA-5654727	2.638804e-02	1.579
NPAS4 regulates expression of target genes	R-HSA-9768919	2.638804e-02	1.579
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.638804e-02	1.579
Signaling by FGFR3	R-HSA-5654741	2.648625e-02	1.577
p75NTR signals via NF-kB	R-HSA-193639	2.704905e-02	1.568
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.887609e-02	1.539
Late Phase of HIV Life Cycle	R-HSA-162599	2.904454e-02	1.537
Downregulation of ERBB2 signaling	R-HSA-8863795	2.978004e-02	1.526
Regulation of TNFR1 signaling	R-HSA-5357905	2.989866e-02	1.524
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.033550e-02	1.518
Muscle contraction	R-HSA-397014	3.094491e-02	1.509
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.216136e-02	1.493
TRIF-mediated programmed cell death	R-HSA-2562578	3.216136e-02	1.493
Activation of RAC1	R-HSA-428540	3.438974e-02	1.464
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.438974e-02	1.464
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.717395e-02	1.430
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.507701e-02	1.455
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.433811e-02	1.464
Signaling by ERBB2	R-HSA-1227986	3.494193e-02	1.457
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.765374e-02	1.424
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	3.522341e-02	1.453
NF-kB is activated and signals survival	R-HSA-209560	3.438974e-02	1.464
Signaling by FGFR1 in disease	R-HSA-5655302	3.433811e-02	1.464
Calmodulin induced events	R-HSA-111933	3.468245e-02	1.460
Regulation of TP53 Degradation	R-HSA-6804757	3.468245e-02	1.460
CaM pathway	R-HSA-111997	3.468245e-02	1.460
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.191714e-02	1.496
Potassium Channels	R-HSA-1296071	3.330880e-02	1.477
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.607086e-02	1.443
Phase 4 - resting membrane potential	R-HSA-5576886	3.342594e-02	1.476
Formation of the nephric duct	R-HSA-9830364	3.342283e-02	1.476
G2/M DNA damage checkpoint	R-HSA-69473	3.840896e-02	1.416
Signaling by EGFR in Cancer	R-HSA-1643713	3.902297e-02	1.409
TRP channels	R-HSA-3295583	3.902297e-02	1.409
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	4.070277e-02	1.390
Nucleotide Excision Repair	R-HSA-5696398	4.253894e-02	1.371
Regulation by c-FLIP	R-HSA-3371378	4.303191e-02	1.366
Dimerization of procaspase-8	R-HSA-69416	4.303191e-02	1.366
Adrenoceptors	R-HSA-390696	4.303191e-02	1.366
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.303191e-02	1.366
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	4.303191e-02	1.366
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.303191e-02	1.366
Modulation by Mtb of host immune system	R-HSA-9637628	4.303191e-02	1.366
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.325597e-02	1.364
Regulation of IFNG signaling	R-HSA-877312	4.325597e-02	1.364
VLDLR internalisation and degradation	R-HSA-8866427	4.325597e-02	1.364
mRNA Splicing	R-HSA-72172	4.361573e-02	1.360
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	4.391831e-02	1.357
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.391831e-02	1.357
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.391831e-02	1.357
Selective autophagy	R-HSA-9663891	4.412807e-02	1.355
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.438104e-02	1.353
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.463968e-02	1.350
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	4.977814e-02	1.303
Signaling by TCF7L2 mutants	R-HSA-5339700	4.977814e-02	1.303
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.138032e-02	1.289
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	5.138032e-02	1.289
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.138032e-02	1.289
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.138032e-02	1.289
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	5.138032e-02	1.289
Inactivation of CDC42 and RAC1	R-HSA-428543	5.572212e-02	1.254
CASP8 activity is inhibited	R-HSA-5218900	5.572212e-02	1.254
ALK mutants bind TKIs	R-HSA-9700645	5.572212e-02	1.254
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.337337e-02	1.273
Notch-HLH transcription pathway	R-HSA-350054	5.140381e-02	1.289
Phase 0 - rapid depolarisation	R-HSA-5576892	5.202301e-02	1.284
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	5.150105e-02	1.288
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.027831e-02	1.299
HIV Transcription Elongation	R-HSA-167169	5.637281e-02	1.249
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.637281e-02	1.249
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	5.637281e-02	1.249
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.617544e-02	1.250
PI3K Cascade	R-HSA-109704	4.672781e-02	1.330
Clathrin-mediated endocytosis	R-HSA-8856828	4.834379e-02	1.316
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.138032e-02	1.289
Interleukin-6 signaling	R-HSA-1059683	5.337337e-02	1.273
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.337337e-02	1.273
Separation of Sister Chromatids	R-HSA-2467813	4.704611e-02	1.327
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	4.521945e-02	1.345
Mitotic Anaphase	R-HSA-68882	5.502785e-02	1.259
DAG and IP3 signaling	R-HSA-1489509	5.417307e-02	1.266
FGFR1 mutant receptor activation	R-HSA-1839124	4.531115e-02	1.344
Oxidative Stress Induced Senescence	R-HSA-2559580	5.245875e-02	1.280
HIV Life Cycle	R-HSA-162587	4.752239e-02	1.323
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	5.140381e-02	1.289
AKT phosphorylates targets in the nucleus	R-HSA-198693	5.572212e-02	1.254
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	5.572212e-02	1.254
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	5.140381e-02	1.289
Formation of RNA Pol II elongation complex	R-HSA-112382	5.720225e-02	1.243
Neurexins and neuroligins	R-HSA-6794361	5.720225e-02	1.243
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.762924e-02	1.239
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.770598e-02	1.239
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	5.806148e-02	1.236
Dual Incision in GG-NER	R-HSA-5696400	5.822042e-02	1.235
NOD1/2 Signaling Pathway	R-HSA-168638	5.822042e-02	1.235
DNA Repair	R-HSA-73894	5.857587e-02	1.232
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.012412e-02	1.221
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.012412e-02	1.221
Signaling downstream of RAS mutants	R-HSA-9649948	6.012412e-02	1.221
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.012412e-02	1.221
Signaling by RAS mutants	R-HSA-6802949	6.012412e-02	1.221
RNA Polymerase II Transcription Elongation	R-HSA-75955	6.298536e-02	1.201
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.389927e-02	1.195
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	6.474999e-02	1.189
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	6.474999e-02	1.189
Toll-like Receptor Cascades	R-HSA-168898	6.507972e-02	1.187
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	6.513556e-02	1.186
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	6.513556e-02	1.186
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	6.513556e-02	1.186
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	6.513556e-02	1.186
Signaling by NOTCH1 in Cancer	R-HSA-2644603	6.513556e-02	1.186
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.782896e-02	1.169
Regulation of signaling by CBL	R-HSA-912631	6.817132e-02	1.166
Rap1 signalling	R-HSA-392517	6.817132e-02	1.166
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.865518e-02	1.163
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	6.909508e-02	1.161
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	8.202374e-02	1.086
Regulation of TP53 Expression	R-HSA-6804754	8.202374e-02	1.086
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	8.202374e-02	1.086
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	8.202374e-02	1.086
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	8.202374e-02	1.086
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	8.202374e-02	1.086
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	8.202374e-02	1.086
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	8.202374e-02	1.086
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	8.202374e-02	1.086
Potassium transport channels	R-HSA-1296067	8.202374e-02	1.086
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	8.202374e-02	1.086
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	8.202374e-02	1.086
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	8.202374e-02	1.086
TWIK related potassium channel (TREK)	R-HSA-1299503	8.202374e-02	1.086
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	7.049429e-02	1.152
TRAIL signaling	R-HSA-75158	7.049429e-02	1.152
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	7.049429e-02	1.152
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	7.049429e-02	1.152
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	7.049429e-02	1.152
CREB phosphorylation	R-HSA-199920	9.231102e-02	1.035
Formation of apoptosome	R-HSA-111458	7.020365e-02	1.154
Regulation of the apoptosome activity	R-HSA-9627069	7.020365e-02	1.154
MET activates RAP1 and RAC1	R-HSA-8875555	7.020365e-02	1.154
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	8.641449e-02	1.063
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	7.737641e-02	1.111
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.122694e-02	1.040
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.124866e-02	1.040
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.258886e-02	1.083
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.124866e-02	1.040
IRS-related events triggered by IGF1R	R-HSA-2428928	7.107777e-02	1.148
Oncogenic MAPK signaling	R-HSA-6802957	9.147731e-02	1.039
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.020365e-02	1.154
Signaling by FGFR1	R-HSA-5654736	8.258886e-02	1.083
Prolonged ERK activation events	R-HSA-169893	9.122694e-02	1.040
IRS-mediated signalling	R-HSA-112399	8.988675e-02	1.046
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.584618e-02	1.120
Signaling by RAF1 mutants	R-HSA-9656223	6.996521e-02	1.155
Diseases of mitotic cell cycle	R-HSA-9675126	8.558088e-02	1.068
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.988675e-02	1.046
Budding and maturation of HIV virion	R-HSA-162588	7.622972e-02	1.118
Cyclin E associated events during G1/S transition	R-HSA-69202	8.484806e-02	1.071
Signaling by FLT3 fusion proteins	R-HSA-9703465	8.898112e-02	1.051
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	8.048449e-02	1.094
G2/M Checkpoints	R-HSA-69481	8.517077e-02	1.070
IGF1R signaling cascade	R-HSA-2428924	9.097087e-02	1.041
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	7.737641e-02	1.111
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.736244e-02	1.111
G0 and Early G1	R-HSA-1538133	8.558088e-02	1.068
Ca-dependent events	R-HSA-111996	7.747571e-02	1.111
Glycogen synthesis	R-HSA-3322077	7.923710e-02	1.101
Neuronal System	R-HSA-112316	7.905175e-02	1.102
Cardiac conduction	R-HSA-5576891	7.504814e-02	1.125
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.898112e-02	1.051
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	8.546716e-02	1.068
Cell-extracellular matrix interactions	R-HSA-446353	7.737641e-02	1.111
Interleukin-1 family signaling	R-HSA-446652	7.991365e-02	1.097
Signaling by PTK6	R-HSA-8848021	8.399278e-02	1.076
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.399278e-02	1.076
Zygotic genome activation (ZGA)	R-HSA-9819196	9.124866e-02	1.040
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.898112e-02	1.051
Transcriptional Regulation by MECP2	R-HSA-8986944	9.102842e-02	1.041
Netrin-1 signaling	R-HSA-373752	9.394036e-02	1.027
Cyclin D associated events in G1	R-HSA-69231	9.394036e-02	1.027
G1 Phase	R-HSA-69236	9.394036e-02	1.027
Transport of the SLBP independent Mature mRNA	R-HSA-159227	9.557250e-02	1.020
Nuclear RNA decay	R-HSA-9930044	9.557250e-02	1.020
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.788142e-02	1.009
Signaling by Interleukins	R-HSA-449147	9.813954e-02	1.008
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.829768e-02	1.007
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.829768e-02	1.007
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	9.852239e-02	1.006
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.002872e-01	0.999
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.002872e-01	0.999
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.002872e-01	0.999
Signaling by FGFR	R-HSA-190236	1.023864e-01	0.990
Eukaryotic Translation Elongation	R-HSA-156842	1.035578e-01	0.985
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.041868e-01	0.982
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.042643e-01	0.982
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.042643e-01	0.982
Transcriptional Regulation by NPAS4	R-HSA-9634815	1.046763e-01	0.980
Signaling by MET	R-HSA-6806834	1.053393e-01	0.977
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.061981e-01	0.974
Deubiquitination	R-HSA-5688426	1.100642e-01	0.958
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.114643e-01	0.953
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.114643e-01	0.953
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.114643e-01	0.953
HIV elongation arrest and recovery	R-HSA-167287	1.123386e-01	0.949
Pausing and recovery of HIV elongation	R-HSA-167290	1.123386e-01	0.949
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.165288e-01	0.934
Cohesin Loading onto Chromatin	R-HSA-2470946	1.165288e-01	0.934
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	1.165288e-01	0.934
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.165288e-01	0.934
RAF activation	R-HSA-5673000	1.174472e-01	0.930
Signaling by NOTCH2	R-HSA-1980145	1.174472e-01	0.930
FGFR2 alternative splicing	R-HSA-6803529	1.180242e-01	0.928
Regulation of IFNA/IFNB signaling	R-HSA-912694	1.180242e-01	0.928
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.180242e-01	0.928
Diseases of programmed cell death	R-HSA-9645723	1.187288e-01	0.925
MET activates PTPN11	R-HSA-8865999	1.188879e-01	0.925
FasL/ CD95L signaling	R-HSA-75157	1.188879e-01	0.925
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.188879e-01	0.925
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.214230e-01	0.916
HIV Infection	R-HSA-162906	1.214273e-01	0.916
Cilium Assembly	R-HSA-5617833	1.219543e-01	0.914
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.222248e-01	0.913
Transcription of the HIV genome	R-HSA-167172	1.223631e-01	0.912
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	1.224253e-01	0.912
Regulation of FZD by ubiquitination	R-HSA-4641263	1.224253e-01	0.912
Glycogen storage diseases	R-HSA-3229121	1.224253e-01	0.912
Specification of primordial germ cells	R-HSA-9827857	1.224253e-01	0.912
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.236399e-01	0.908
Termination of translesion DNA synthesis	R-HSA-5656169	1.251157e-01	0.903
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.251157e-01	0.903
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.283248e-01	0.892
PI Metabolism	R-HSA-1483255	1.292665e-01	0.889
Oncogene Induced Senescence	R-HSA-2559585	1.293056e-01	0.888
Signaling by NOTCH1	R-HSA-1980143	1.296875e-01	0.887
Interleukin-12 signaling	R-HSA-9020591	1.296875e-01	0.887
Negative regulation of MAPK pathway	R-HSA-5675221	1.315946e-01	0.881
TNFR1-mediated ceramide production	R-HSA-5626978	1.589416e-01	0.799
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.589416e-01	0.799
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.589416e-01	0.799
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	2.010166e-01	0.697
IRS activation	R-HSA-74713	2.010166e-01	0.697
G2 Phase	R-HSA-68911	2.010166e-01	0.697
NOSIP mediated eNOS trafficking	R-HSA-203754	2.010166e-01	0.697
ROBO receptors bind AKAP5	R-HSA-9010642	1.428195e-01	0.845
Type I hemidesmosome assembly	R-HSA-446107	1.428195e-01	0.845
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.708454e-01	0.767
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.708454e-01	0.767
ARMS-mediated activation	R-HSA-170984	1.708454e-01	0.767
Lipophagy	R-HSA-9613354	1.708454e-01	0.767
WNT mediated activation of DVL	R-HSA-201688	1.708454e-01	0.767
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.444101e-01	0.840
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.444101e-01	0.840
MAPK3 (ERK1) activation	R-HSA-110056	2.002706e-01	0.698
CRMPs in Sema3A signaling	R-HSA-399956	1.664310e-01	0.779
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.396546e-01	0.855
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.396546e-01	0.855
GAB1 signalosome	R-HSA-180292	1.396546e-01	0.855
DCC mediated attractive signaling	R-HSA-418885	1.895497e-01	0.722
PI-3K cascade:FGFR3	R-HSA-5654710	1.578743e-01	0.802
PI-3K cascade:FGFR4	R-HSA-5654720	1.770022e-01	0.752
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.385941e-01	0.858
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	1.992447e-01	0.701
Striated Muscle Contraction	R-HSA-390522	1.988773e-01	0.701
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.824280e-01	0.739
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.970031e-01	0.706
Dual incision in TC-NER	R-HSA-6782135	1.643130e-01	0.784
Specification of the neural plate border	R-HSA-9834899	1.578743e-01	0.802
Apoptosis induced DNA fragmentation	R-HSA-140342	2.002706e-01	0.698
DNA Damage Bypass	R-HSA-73893	1.434045e-01	0.843
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.434045e-01	0.843
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.434045e-01	0.843
G1/S DNA Damage Checkpoints	R-HSA-69615	1.416771e-01	0.849
Translesion Synthesis by POLH	R-HSA-110320	1.578743e-01	0.802
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	1.664310e-01	0.779
Inwardly rectifying K+ channels	R-HSA-1296065	1.675339e-01	0.776
Frs2-mediated activation	R-HSA-170968	1.444101e-01	0.840
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	1.428195e-01	0.845
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.708454e-01	0.767
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.431680e-01	0.844
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.589416e-01	0.799
PI3K/AKT activation	R-HSA-198203	2.002706e-01	0.698
Translesion synthesis by REV1	R-HSA-110312	1.895497e-01	0.722
Response of endothelial cells to shear stress	R-HSA-9860931	1.441163e-01	0.841
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.010166e-01	0.697
Sodium/Proton exchangers	R-HSA-425986	1.428195e-01	0.845
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	1.708454e-01	0.767
Trafficking of AMPA receptors	R-HSA-399719	1.527446e-01	0.816
Interleukin-6 family signaling	R-HSA-6783589	1.482488e-01	0.829
Interleukin-7 signaling	R-HSA-1266695	1.645460e-01	0.784
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.004112e-01	0.698
S Phase	R-HSA-69242	1.865655e-01	0.729
Ion homeostasis	R-HSA-5578775	1.428277e-01	0.845
Calcineurin activates NFAT	R-HSA-2025928	1.708454e-01	0.767
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.385941e-01	0.858
Activation of ATR in response to replication stress	R-HSA-176187	1.829249e-01	0.738
HATs acetylate histones	R-HSA-3214847	1.637267e-01	0.786
Protein-protein interactions at synapses	R-HSA-6794362	1.446282e-01	0.840
Signaling by FGFR in disease	R-HSA-1226099	1.795295e-01	0.746
MAPK1/MAPK3 signaling	R-HSA-5684996	1.544357e-01	0.811
Organelle biogenesis and maintenance	R-HSA-1852241	1.566548e-01	0.805
RAF/MAP kinase cascade	R-HSA-5673001	2.000702e-01	0.699
MTOR signalling	R-HSA-165159	1.431680e-01	0.844
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.725075e-01	0.763
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.010166e-01	0.697
Formation of intermediate mesoderm	R-HSA-9761174	2.002706e-01	0.698
PLC beta mediated events	R-HSA-112043	1.993004e-01	0.700
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	1.416771e-01	0.849
Insulin receptor signalling cascade	R-HSA-74751	1.516054e-01	0.819
MAPK family signaling cascades	R-HSA-5683057	1.723486e-01	0.764
Protein methylation	R-HSA-8876725	1.895497e-01	0.722
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.855940e-01	0.731
Cellular responses to stimuli	R-HSA-8953897	1.943626e-01	0.711
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	2.010166e-01	0.697
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.708454e-01	0.767
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	1.444101e-01	0.840
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.444101e-01	0.840
Cardiogenesis	R-HSA-9733709	1.829249e-01	0.738
Interferon gamma signaling	R-HSA-877300	1.565057e-01	0.805
Cytokine Signaling in Immune system	R-HSA-1280215	1.561477e-01	0.806
Interleukin-12 family signaling	R-HSA-447115	1.715802e-01	0.766
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.002706e-01	0.698
Regulation of MECP2 expression and activity	R-HSA-9022692	1.829249e-01	0.738
Interferon Signaling	R-HSA-913531	1.607075e-01	0.794
Muscarinic acetylcholine receptors	R-HSA-390648	2.010166e-01	0.697
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.547759e-01	0.810
TBC/RABGAPs	R-HSA-8854214	1.552381e-01	0.809
Kinesins	R-HSA-983189	1.872888e-01	0.727
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.829249e-01	0.738
Signaling by Leptin	R-HSA-2586552	2.002706e-01	0.698
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.030916e-01	0.692
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.090166e-01	0.680
Host Interactions of HIV factors	R-HSA-162909	2.090604e-01	0.680
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.105100e-01	0.677
Diseases of Telomere Maintenance	R-HSA-9673013	2.105100e-01	0.677
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.105100e-01	0.677
TWIK-related spinal cord K+ channel (TRESK)	R-HSA-1299344	2.105100e-01	0.677
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.105100e-01	0.677
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.105100e-01	0.677
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.105100e-01	0.677
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.105100e-01	0.677
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.105100e-01	0.677
TICAM1 deficiency - HSE	R-HSA-5602566	2.105100e-01	0.677
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.120357e-01	0.674
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	2.122345e-01	0.673
Translesion synthesis by POLI	R-HSA-5656121	2.136089e-01	0.670
Phosphorylation of the APC/C	R-HSA-176412	2.136089e-01	0.670
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	2.136089e-01	0.670
Regulation of BACH1 activity	R-HSA-9708530	2.136089e-01	0.670
Mitophagy	R-HSA-5205647	2.153478e-01	0.667
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.175275e-01	0.662
Formation of the Early Elongation Complex	R-HSA-113418	2.175275e-01	0.662
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.176252e-01	0.662
Signaling by PDGFR in disease	R-HSA-9671555	2.176252e-01	0.662
Assembly Of The HIV Virion	R-HSA-175474	2.176252e-01	0.662
ESR-mediated signaling	R-HSA-8939211	2.211792e-01	0.655
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.216197e-01	0.654
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	2.985202e-01	0.525
Mitochondrial transcription initiation	R-HSA-163282	2.985202e-01	0.525
Interactions of Tat with host cellular proteins	R-HSA-176034	2.985202e-01	0.525
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.985202e-01	0.525
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	2.985202e-01	0.525
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.985202e-01	0.525
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.985202e-01	0.525
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.985202e-01	0.525
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.985202e-01	0.525
TRAF3 deficiency - HSE	R-HSA-5602571	2.985202e-01	0.525
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	2.985202e-01	0.525
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.985202e-01	0.525
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	2.985202e-01	0.525
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.985202e-01	0.525
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.985202e-01	0.525
Intestinal infectious diseases	R-HSA-8942233	2.985202e-01	0.525
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.985202e-01	0.525
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.985202e-01	0.525
MyD88 deficiency (TLR5)	R-HSA-5602680	2.985202e-01	0.525
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.985202e-01	0.525
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.441653e-01	0.612
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.767239e-01	0.424
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.767239e-01	0.424
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.767239e-01	0.424
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.767239e-01	0.424
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.767239e-01	0.424
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.876260e-01	0.541
STAT5 Activation	R-HSA-9645135	2.876260e-01	0.541
ChREBP activates metabolic gene expression	R-HSA-163765	2.307707e-01	0.637
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.307707e-01	0.637
RHOBTB3 ATPase cycle	R-HSA-9706019	2.307707e-01	0.637
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	2.620387e-01	0.582
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.620387e-01	0.582
Signaling by GSK3beta mutants	R-HSA-5339716	2.620387e-01	0.582
Activated NTRK2 signals through CDK5	R-HSA-9032845	3.307936e-01	0.480
MET activates PI3K/AKT signaling	R-HSA-8851907	3.307936e-01	0.480
Netrin mediated repulsion signals	R-HSA-418886	3.307936e-01	0.480
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	3.307936e-01	0.480
SOS-mediated signalling	R-HSA-112412	3.307936e-01	0.480
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.462132e-01	0.350
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.462132e-01	0.350
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.462132e-01	0.350
Defective GCLC causes HAGGSD	R-HSA-5578999	4.462132e-01	0.350
Invadopodia formation	R-HSA-8941237	4.462132e-01	0.350
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.462132e-01	0.350
IRAK4 deficiency (TLR5)	R-HSA-5603037	4.462132e-01	0.350
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.384496e-01	0.623
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.384496e-01	0.623
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.384496e-01	0.623
Translesion synthesis by POLK	R-HSA-5655862	2.384496e-01	0.623
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.937894e-01	0.532
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.937894e-01	0.532
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.937894e-01	0.532
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.937894e-01	0.532
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.937894e-01	0.532
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.937894e-01	0.532
PI3K events in ERBB2 signaling	R-HSA-1963642	2.639145e-01	0.579
RSK activation	R-HSA-444257	3.731934e-01	0.428
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.731934e-01	0.428
PI-3K cascade:FGFR1	R-HSA-5654689	2.389322e-01	0.622
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.322913e-01	0.634
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.556425e-01	0.592
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.161082e-01	0.500
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.577220e-01	0.446
Interleukin-21 signaling	R-HSA-9020958	4.144604e-01	0.383
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	4.144604e-01	0.383
G1/S-Specific Transcription	R-HSA-69205	2.496604e-01	0.603
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.496604e-01	0.603
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.753425e-01	0.560
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.753425e-01	0.560
PI-3K cascade:FGFR2	R-HSA-5654695	3.056780e-01	0.515
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	3.056780e-01	0.515
Activation of G protein gated Potassium channels	R-HSA-1296041	3.056780e-01	0.515
G protein gated Potassium channels	R-HSA-1296059	3.056780e-01	0.515
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.433372e-01	0.614
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.425491e-01	0.465
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.674068e-01	0.573
Beta-catenin phosphorylation cascade	R-HSA-196299	3.894606e-01	0.410
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	3.285505e-01	0.483
Integrin signaling	R-HSA-354192	3.156933e-01	0.501
IPs transport between nucleus and cytosol	R-HSA-1855170	3.156933e-01	0.501
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.543205e-01	0.343
Interaction between L1 and Ankyrins	R-HSA-445095	3.515818e-01	0.454
RNA Polymerase I Transcription Termination	R-HSA-73863	3.515818e-01	0.454
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.207951e-01	0.376
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	4.207951e-01	0.376
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.553781e-01	0.593
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.954610e-01	0.403
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.983052e-01	0.525
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.746850e-01	0.426
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	3.568725e-01	0.447
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.543362e-01	0.595
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.656286e-01	0.576
Downstream signaling of activated FGFR3	R-HSA-5654708	3.977779e-01	0.400
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.977779e-01	0.400
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	4.515680e-01	0.345
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.983733e-01	0.400
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.207826e-01	0.376
Downstream signaling of activated FGFR4	R-HSA-5654716	4.207826e-01	0.376
Regulation of RAS by GAPs	R-HSA-5658442	3.795409e-01	0.421
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.361018e-01	0.474
Degradation of DVL	R-HSA-4641258	4.190956e-01	0.378
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.190956e-01	0.378
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	4.190956e-01	0.378
Voltage gated Potassium channels	R-HSA-1296072	4.190956e-01	0.378
Metabolism of non-coding RNA	R-HSA-194441	3.959619e-01	0.402
snRNP Assembly	R-HSA-191859	3.959619e-01	0.402
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	3.483672e-01	0.458
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.772355e-01	0.423
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.148089e-01	0.382
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	3.749055e-01	0.426
Formation of a pool of free 40S subunits	R-HSA-72689	3.749055e-01	0.426
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.031268e-01	0.395
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.488334e-01	0.348
Extra-nuclear estrogen signaling	R-HSA-9009391	2.570560e-01	0.590
Cellular response to starvation	R-HSA-9711097	3.424580e-01	0.465
RNA Polymerase III Transcription	R-HSA-74158	3.983733e-01	0.400
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.639145e-01	0.579
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.639145e-01	0.579
Circadian clock	R-HSA-9909396	2.289602e-01	0.640
Ub-specific processing proteases	R-HSA-5689880	3.403563e-01	0.468
Formation of definitive endoderm	R-HSA-9823730	3.425491e-01	0.465
RNA Polymerase III Transcription Initiation	R-HSA-76046	4.207826e-01	0.376
Interferon alpha/beta signaling	R-HSA-909733	3.592649e-01	0.445
DARPP-32 events	R-HSA-180024	2.363486e-01	0.626
GABA receptor activation	R-HSA-977443	4.124906e-01	0.385
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.257621e-01	0.487
Estrogen-dependent gene expression	R-HSA-9018519	2.750364e-01	0.561
Sensing of DNA Double Strand Breaks	R-HSA-5693548	2.620387e-01	0.582
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.384496e-01	0.623
Killing mechanisms	R-HSA-9664420	4.207951e-01	0.376
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	4.207951e-01	0.376
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	3.705344e-01	0.431
G1/S Transition	R-HSA-69206	3.037198e-01	0.518
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.656286e-01	0.576
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.411732e-01	0.467
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.556425e-01	0.592
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.690408e-01	0.433
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.216972e-01	0.375
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.753425e-01	0.560
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.322913e-01	0.634
Meiosis	R-HSA-1500620	4.195879e-01	0.377
TCF dependent signaling in response to WNT	R-HSA-201681	3.575716e-01	0.447
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	4.144604e-01	0.383
Regulation of CDH11 function	R-HSA-9762292	4.543205e-01	0.343
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.568725e-01	0.447
Peptide chain elongation	R-HSA-156902	2.628161e-01	0.580
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	4.216972e-01	0.375
Adipogenesis	R-HSA-9843745	3.789240e-01	0.421
Apoptotic factor-mediated response	R-HSA-111471	2.898499e-01	0.538
Interleukin-9 signaling	R-HSA-8985947	3.731934e-01	0.428
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.838062e-01	0.416
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.876260e-01	0.541
Role of second messengers in netrin-1 signaling	R-HSA-418890	2.937894e-01	0.532
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.731934e-01	0.428
Synaptic adhesion-like molecules	R-HSA-8849932	2.898499e-01	0.538
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	3.894606e-01	0.410
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.593602e-01	0.586
Hedgehog 'off' state	R-HSA-5610787	4.399284e-01	0.357
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.324220e-01	0.634
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.492599e-01	0.457
Ephrin signaling	R-HSA-3928664	2.898499e-01	0.538
Signalling to ERKs	R-HSA-187687	3.776131e-01	0.423
Opioid Signalling	R-HSA-111885	2.903035e-01	0.537
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.285505e-01	0.483
Meiotic recombination	R-HSA-912446	3.971701e-01	0.401
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.413307e-01	0.355
Sema4D in semaphorin signaling	R-HSA-400685	3.056780e-01	0.515
Regulation of PTEN stability and activity	R-HSA-8948751	2.983052e-01	0.525
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.887243e-01	0.540
G-protein mediated events	R-HSA-112040	2.776152e-01	0.557
Interleukin-1 signaling	R-HSA-9020702	2.570560e-01	0.590
Cellular responses to mechanical stimuli	R-HSA-9855142	2.412191e-01	0.618
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.441653e-01	0.612
Transcription from mitochondrial promoters	R-HSA-75944	3.767239e-01	0.424
Ca2+ activated K+ channels	R-HSA-1296052	3.307936e-01	0.480
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	3.731934e-01	0.428
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	3.731934e-01	0.428
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.433372e-01	0.614
Arachidonate production from DAG	R-HSA-426048	4.543205e-01	0.343
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.515818e-01	0.454
Fanconi Anemia Pathway	R-HSA-6783310	4.359897e-01	0.361
Epigenetic regulation of gene expression	R-HSA-212165	3.688819e-01	0.433
Transcriptional regulation by RUNX3	R-HSA-8878159	4.008402e-01	0.397
Signaling by Nuclear Receptors	R-HSA-9006931	2.572575e-01	0.590
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	2.384496e-01	0.623
Nuclear Envelope Breakdown	R-HSA-2980766	2.444089e-01	0.612
Release of Hh-Np from the secreting cell	R-HSA-5362798	2.441653e-01	0.612
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.307936e-01	0.480
Semaphorin interactions	R-HSA-373755	3.326872e-01	0.478
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	2.830548e-01	0.548
Transmission across Chemical Synapses	R-HSA-112315	4.293675e-01	0.367
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.411732e-01	0.467
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.611997e-01	0.442
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.387282e-01	0.358
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.384496e-01	0.623
PKMTs methylate histone lysines	R-HSA-3214841	3.411732e-01	0.467
Hedgehog ligand biogenesis	R-HSA-5358346	3.971701e-01	0.401
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	4.359897e-01	0.361
Nuclear signaling by ERBB4	R-HSA-1251985	3.224138e-01	0.492
Activation of BH3-only proteins	R-HSA-114452	4.207826e-01	0.376
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.305511e-01	0.637
Cellular responses to stress	R-HSA-2262752	2.338096e-01	0.631
EPH-Ephrin signaling	R-HSA-2682334	4.302328e-01	0.366
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.878508e-01	0.411
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.985202e-01	0.525
Regulation of cortical dendrite branching	R-HSA-8985801	3.767239e-01	0.424
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.767239e-01	0.424
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	3.767239e-01	0.424
Bicarbonate transporters	R-HSA-425381	2.307707e-01	0.637
MET interacts with TNS proteins	R-HSA-8875513	4.462132e-01	0.350
Activation of BMF and translocation to mitochondria	R-HSA-139910	4.462132e-01	0.350
Signaling by LTK	R-HSA-9842663	2.937894e-01	0.532
Co-stimulation by ICOS	R-HSA-9927354	3.731934e-01	0.428
mTORC1-mediated signalling	R-HSA-166208	2.389322e-01	0.622
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.257621e-01	0.487
TGFBR3 expression	R-HSA-9839394	3.056780e-01	0.515
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.894606e-01	0.410
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.854809e-01	0.544
Interleukin-27 signaling	R-HSA-9020956	4.543205e-01	0.343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.543205e-01	0.343
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.224138e-01	0.492
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	3.568725e-01	0.447
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	4.515680e-01	0.345
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.476472e-01	0.349
Signaling by Insulin receptor	R-HSA-74752	3.238611e-01	0.490
TCR signaling	R-HSA-202403	3.722513e-01	0.429
Signaling by FGFR4 in disease	R-HSA-5655291	3.577220e-01	0.446
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	3.354070e-01	0.474
Regulation of pyruvate metabolism	R-HSA-9861718	3.098547e-01	0.509
Interleukin-20 family signaling	R-HSA-8854691	4.476472e-01	0.349
Effects of PIP2 hydrolysis	R-HSA-114508	3.362117e-01	0.473
Interactions of Rev with host cellular proteins	R-HSA-177243	3.224138e-01	0.492
Signal attenuation	R-HSA-74749	4.543205e-01	0.343
Receptor Mediated Mitophagy	R-HSA-8934903	4.543205e-01	0.343
Cell-Cell communication	R-HSA-1500931	4.394717e-01	0.357
Glycogen metabolism	R-HSA-8982491	3.224138e-01	0.492
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.529831e-01	0.344
Signaling by TGFB family members	R-HSA-9006936	2.858247e-01	0.544
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.198958e-01	0.495
RSV-host interactions	R-HSA-9833110	3.016813e-01	0.520
Interleukin-2 family signaling	R-HSA-451927	3.224138e-01	0.492
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	3.651345e-01	0.438
Regulated proteolysis of p75NTR	R-HSA-193692	4.144604e-01	0.383
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.362117e-01	0.473
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.928313e-01	0.533
Transcriptional regulation by RUNX1	R-HSA-8878171	3.840174e-01	0.416
Signaling by SCF-KIT	R-HSA-1433557	2.595340e-01	0.586
PI5P Regulates TP53 Acetylation	R-HSA-6811555	3.257621e-01	0.487
Downstream signal transduction	R-HSA-186763	2.753425e-01	0.560
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	4.207951e-01	0.376
Signal transduction by L1	R-HSA-445144	3.425491e-01	0.465
Amine ligand-binding receptors	R-HSA-375280	2.760448e-01	0.559
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.632092e-01	0.440
Breakdown of the nuclear lamina	R-HSA-352238	2.985202e-01	0.525
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.441653e-01	0.612
DSCAM interactions	R-HSA-376172	3.767239e-01	0.424
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.462132e-01	0.350
Maturation of nucleoprotein	R-HSA-9683610	3.257621e-01	0.487
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	3.577220e-01	0.446
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.144604e-01	0.383
MAPK1 (ERK2) activation	R-HSA-112411	4.144604e-01	0.383
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	4.515680e-01	0.345
SARS-CoV-2-host interactions	R-HSA-9705683	3.324940e-01	0.478
Glycolysis	R-HSA-70171	3.366127e-01	0.473
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.590561e-01	0.445
Signaling by NOTCH3	R-HSA-9012852	3.303635e-01	0.481
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.894606e-01	0.410
Nuclear import of Rev protein	R-HSA-180746	3.568725e-01	0.447
Formation of the anterior neural plate	R-HSA-9823739	3.894606e-01	0.410
Syndecan interactions	R-HSA-3000170	4.476472e-01	0.349
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.767239e-01	0.424
MECP2 regulates transcription factors	R-HSA-9022707	3.307936e-01	0.480
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.307936e-01	0.480
Growth hormone receptor signaling	R-HSA-982772	2.607743e-01	0.584
Plasma lipoprotein clearance	R-HSA-8964043	3.038332e-01	0.517
Stimuli-sensing channels	R-HSA-2672351	3.483672e-01	0.458
SLC-mediated transport of inorganic anions	R-HSA-9958790	4.397253e-01	0.357
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.156933e-01	0.501
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.338497e-01	0.631
GP1b-IX-V activation signalling	R-HSA-430116	4.144604e-01	0.383
Regulation of CDH11 gene transcription	R-HSA-9762293	4.144604e-01	0.383
MITF-M-dependent gene expression	R-HSA-9856651	4.278433e-01	0.369
Pyroptosis	R-HSA-5620971	3.746850e-01	0.426
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.441653e-01	0.612
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.746850e-01	0.426
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	3.690408e-01	0.433
Translation of Structural Proteins	R-HSA-9683701	2.274923e-01	0.643
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	3.690408e-01	0.433
SARS-CoV-1 Infection	R-HSA-9678108	3.590561e-01	0.445
XBP1(S) activates chaperone genes	R-HSA-381038	4.478658e-01	0.349
Butyrophilin (BTN) family interactions	R-HSA-8851680	4.144604e-01	0.383
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	4.548443e-01	0.342
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.568741e-01	0.340
Cellular response to chemical stress	R-HSA-9711123	4.569606e-01	0.340
Stabilization of p53	R-HSA-69541	4.602108e-01	0.337
Signaling by ALK	R-HSA-201556	4.602108e-01	0.337
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.602108e-01	0.337
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	4.662435e-01	0.331
Signaling by WNT in cancer	R-HSA-4791275	4.662435e-01	0.331
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.669540e-01	0.331
Signaling by Hedgehog	R-HSA-5358351	4.675777e-01	0.330
Eukaryotic Translation Initiation	R-HSA-72613	4.691883e-01	0.329
Cap-dependent Translation Initiation	R-HSA-72737	4.691883e-01	0.329
Deadenylation of mRNA	R-HSA-429947	4.732195e-01	0.325
TRAF6 mediated NF-kB activation	R-HSA-933542	4.732195e-01	0.325
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.735670e-01	0.325
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	4.782510e-01	0.320
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.805039e-01	0.318
Attenuation phase	R-HSA-3371568	4.805039e-01	0.318
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.805492e-01	0.318
Mitochondrial biogenesis	R-HSA-1592230	4.812728e-01	0.318
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	4.816453e-01	0.317
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.816453e-01	0.317
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.816453e-01	0.317
Golgi-to-ER retrograde transport	R-HSA-8856688	4.832785e-01	0.316
Eukaryotic Translation Termination	R-HSA-72764	4.842465e-01	0.315
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.847788e-01	0.314
Developmental Cell Lineages	R-HSA-9734767	4.848795e-01	0.314
Switching of origins to a post-replicative state	R-HSA-69052	4.877433e-01	0.312
G-protein beta:gamma signalling	R-HSA-397795	4.885709e-01	0.311
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	4.885709e-01	0.311
MITF-M-regulated melanocyte development	R-HSA-9730414	4.902448e-01	0.310
Metal ion SLC transporters	R-HSA-425410	4.921210e-01	0.308
Signaling by APC mutants	R-HSA-4839744	4.925744e-01	0.308
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.925744e-01	0.308
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.925744e-01	0.308
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.925744e-01	0.308
LGI-ADAM interactions	R-HSA-5682910	4.925744e-01	0.308
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.925744e-01	0.308
Formation of the posterior neural plate	R-HSA-9832991	4.925744e-01	0.308
Synthesis of PI	R-HSA-1483226	4.925744e-01	0.308
PECAM1 interactions	R-HSA-210990	4.925744e-01	0.308
ATP-dependent chromatin remodelers	R-HSA-9932444	4.983324e-01	0.302
SWI/SNF chromatin remodelers	R-HSA-9932451	4.983324e-01	0.302
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	4.983324e-01	0.302
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.987919e-01	0.302
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.987919e-01	0.302
Transcriptional Regulation by VENTX	R-HSA-8853884	5.005599e-01	0.301
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	5.005599e-01	0.301
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	5.022251e-01	0.299
Regulation of CDH1 Expression and Function	R-HSA-9764265	5.022251e-01	0.299
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	5.079587e-01	0.294
ATP sensitive Potassium channels	R-HSA-1296025	5.079587e-01	0.294
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.079587e-01	0.294
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.079587e-01	0.294
Defective LFNG causes SCDO3	R-HSA-5083630	5.079587e-01	0.294
Signaling by MAP2K mutants	R-HSA-9652169	5.079587e-01	0.294
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.079587e-01	0.294
Regulation of gap junction activity	R-HSA-191650	5.079587e-01	0.294
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.079587e-01	0.294
Electric Transmission Across Gap Junctions	R-HSA-112303	5.079587e-01	0.294
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.079587e-01	0.294
Transmission across Electrical Synapses	R-HSA-112307	5.079587e-01	0.294
Dopamine receptors	R-HSA-390651	5.079587e-01	0.294
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.079587e-01	0.294
Interleukin-38 signaling	R-HSA-9007892	5.079587e-01	0.294
Degradation of CDH1	R-HSA-9766229	5.104721e-01	0.292
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.105534e-01	0.292
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.105534e-01	0.292
PKA activation	R-HSA-163615	5.109155e-01	0.292
RNA Polymerase III Transcription Termination	R-HSA-73980	5.109155e-01	0.292
PKA activation in glucagon signalling	R-HSA-164378	5.109155e-01	0.292
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	5.109155e-01	0.292
Tie2 Signaling	R-HSA-210993	5.109155e-01	0.292
Vesicle-mediated transport	R-HSA-5653656	5.132011e-01	0.290
Gene expression (Transcription)	R-HSA-74160	5.151786e-01	0.288
Early SARS-CoV-2 Infection Events	R-HSA-9772572	5.189776e-01	0.285
MAP2K and MAPK activation	R-HSA-5674135	5.203375e-01	0.284
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	5.203375e-01	0.284
Degradation of GLI2 by the proteasome	R-HSA-5610783	5.203375e-01	0.284
HIV Transcription Initiation	R-HSA-167161	5.203375e-01	0.284
RNA Polymerase II Transcription Initiation	R-HSA-75953	5.203375e-01	0.284
Myogenesis	R-HSA-525793	5.229146e-01	0.282
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	5.229146e-01	0.282
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.229146e-01	0.282
Suppression of phagosomal maturation	R-HSA-9637687	5.229146e-01	0.282
Kidney development	R-HSA-9830369	5.264680e-01	0.279
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.290848e-01	0.276
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.290848e-01	0.276
Sodium/Calcium exchangers	R-HSA-425561	5.290848e-01	0.276
Signaling by AXIN mutants	R-HSA-4839735	5.290848e-01	0.276
Signaling by AMER1 mutants	R-HSA-4839748	5.290848e-01	0.276
SARS-CoV-1-host interactions	R-HSA-9692914	5.300662e-01	0.276
IRE1alpha activates chaperones	R-HSA-381070	5.313854e-01	0.275
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.321405e-01	0.274
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	5.321405e-01	0.274
Calnexin/calreticulin cycle	R-HSA-901042	5.321405e-01	0.274
Deadenylation-dependent mRNA decay	R-HSA-429914	5.357831e-01	0.271
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	5.382354e-01	0.269
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.392875e-01	0.268
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.392875e-01	0.268
Maturation of nucleoprotein	R-HSA-9694631	5.392875e-01	0.268
GABA B receptor activation	R-HSA-977444	5.397989e-01	0.268
Activation of GABAB receptors	R-HSA-991365	5.397989e-01	0.268
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.397989e-01	0.268
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	5.426340e-01	0.265
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.469044e-01	0.262
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.469044e-01	0.262
Signaling by FGFR3 in disease	R-HSA-5655332	5.469044e-01	0.262
ER Quality Control Compartment (ERQC)	R-HSA-901032	5.469044e-01	0.262
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	5.504227e-01	0.259
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	5.523601e-01	0.258
MHC class II antigen presentation	R-HSA-2132295	5.525077e-01	0.258
Downstream signaling of activated FGFR1	R-HSA-5654687	5.532877e-01	0.257
Downstream signaling of activated FGFR2	R-HSA-5654696	5.532877e-01	0.257
PERK regulates gene expression	R-HSA-381042	5.532877e-01	0.257
Reproduction	R-HSA-1474165	5.570445e-01	0.254
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.571967e-01	0.254
RNA Polymerase II Promoter Escape	R-HSA-73776	5.589100e-01	0.253
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.589100e-01	0.253
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.597077e-01	0.252
Signaling by WNT	R-HSA-195721	5.604947e-01	0.251
Defective CYP17A1 causes AH5	R-HSA-5579028	5.628229e-01	0.250
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.628229e-01	0.250
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.628229e-01	0.250
PTK6 Down-Regulation	R-HSA-8849472	5.628229e-01	0.250
Activation of AKT2	R-HSA-165158	5.628229e-01	0.250
Activation of C3 and C5	R-HSA-174577	5.628229e-01	0.250
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.628229e-01	0.250
Inositol transporters	R-HSA-429593	5.628229e-01	0.250
Co-inhibition by BTLA	R-HSA-9927353	5.628229e-01	0.250
NrCAM interactions	R-HSA-447038	5.628229e-01	0.250
Selenocysteine synthesis	R-HSA-2408557	5.630331e-01	0.249
RUNX3 regulates p14-ARF	R-HSA-8951936	5.637652e-01	0.249
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.637652e-01	0.249
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.637652e-01	0.249
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.637652e-01	0.249
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.637652e-01	0.249
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.637652e-01	0.249
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.637652e-01	0.249
Interleukin-35 Signalling	R-HSA-8984722	5.637652e-01	0.249
Repression of WNT target genes	R-HSA-4641265	5.637652e-01	0.249
Interleukin-15 signaling	R-HSA-8983432	5.637652e-01	0.249
OAS antiviral response	R-HSA-8983711	5.637652e-01	0.249
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	5.639993e-01	0.249
Orc1 removal from chromatin	R-HSA-68949	5.639993e-01	0.249
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	5.639993e-01	0.249
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.666892e-01	0.247
Protein hydroxylation	R-HSA-9629569	5.666892e-01	0.247
Telomere Extension By Telomerase	R-HSA-171319	5.702496e-01	0.244
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.730552e-01	0.242
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.739556e-01	0.241
HSF1 activation	R-HSA-3371511	5.739556e-01	0.241
GPVI-mediated activation cascade	R-HSA-114604	5.739556e-01	0.241
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.768399e-01	0.239
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.776404e-01	0.238
EPHB-mediated forward signaling	R-HSA-3928662	5.776404e-01	0.238
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	5.812429e-01	0.236
Smooth Muscle Contraction	R-HSA-445355	5.812429e-01	0.236
Glucose metabolism	R-HSA-70326	5.833344e-01	0.234
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	5.847420e-01	0.233
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.847420e-01	0.233
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.847420e-01	0.233
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.847420e-01	0.233
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.881328e-01	0.231
Regulation of mitotic cell cycle	R-HSA-453276	5.881328e-01	0.231
Viral mRNA Translation	R-HSA-192823	5.882918e-01	0.230
Signaling by Erythropoietin	R-HSA-9006335	5.929065e-01	0.227
mRNA Capping	R-HSA-72086	5.929065e-01	0.227
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	5.929065e-01	0.227
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.929065e-01	0.227
MyD88 deficiency (TLR2/4)	R-HSA-5602498	5.930654e-01	0.227
Basigin interactions	R-HSA-210991	5.930654e-01	0.227
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	5.930654e-01	0.227
TRAF6 mediated IRF7 activation	R-HSA-933541	5.941103e-01	0.226
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.959627e-01	0.225
Defective CFTR causes cystic fibrosis	R-HSA-5678895	5.959627e-01	0.225
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	5.959627e-01	0.225
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	5.959627e-01	0.225
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.959627e-01	0.225
Asymmetric localization of PCP proteins	R-HSA-4608870	5.959627e-01	0.225
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	5.959627e-01	0.225
Formation of axial mesoderm	R-HSA-9796292	5.965695e-01	0.224
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	5.965695e-01	0.224
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	5.965695e-01	0.224
Processing of SMDT1	R-HSA-8949664	5.965695e-01	0.224
Gastrulation	R-HSA-9758941	5.967551e-01	0.224
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.981480e-01	0.223
Generic Transcription Pathway	R-HSA-212436	5.995649e-01	0.222
Inositol phosphate metabolism	R-HSA-1483249	6.035971e-01	0.219
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.104348e-01	0.214
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.115725e-01	0.214
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.115725e-01	0.214
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.115725e-01	0.214
PKB-mediated events	R-HSA-109703	6.115725e-01	0.214
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.115725e-01	0.214
PDE3B signalling	R-HSA-165160	6.115725e-01	0.214
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.115725e-01	0.214
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.115725e-01	0.214
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	6.115725e-01	0.214
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.115725e-01	0.214
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.115725e-01	0.214
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.115725e-01	0.214
CLEC7A/inflammasome pathway	R-HSA-5660668	6.115725e-01	0.214
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.115725e-01	0.214
Pentose phosphate pathway disease	R-HSA-6791465	6.115725e-01	0.214
Phosphorylation of Emi1	R-HSA-176417	6.115725e-01	0.214
Formation of the Editosome	R-HSA-75094	6.115725e-01	0.214
CDC6 association with the ORC:origin complex	R-HSA-68689	6.115725e-01	0.214
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.115725e-01	0.214
Signalling to p38 via RIT and RIN	R-HSA-187706	6.115725e-01	0.214
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.115725e-01	0.214
Sodium-coupled phosphate cotransporters	R-HSA-427652	6.115725e-01	0.214
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.115725e-01	0.214
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	6.115725e-01	0.214
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	6.115725e-01	0.214
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.115725e-01	0.214
MET promotes cell motility	R-HSA-8875878	6.137229e-01	0.212
mRNA Splicing - Minor Pathway	R-HSA-72165	6.138533e-01	0.212
Signaling by TGFBR3	R-HSA-9839373	6.138533e-01	0.212
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	6.138533e-01	0.212
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.146948e-01	0.211
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	6.146948e-01	0.211
SHC1 events in ERBB2 signaling	R-HSA-1250196	6.148400e-01	0.211
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	6.175144e-01	0.209
FRS-mediated FGFR3 signaling	R-HSA-5654706	6.183762e-01	0.209
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	6.183762e-01	0.209
Mitochondrial calcium ion transport	R-HSA-8949215	6.183762e-01	0.209
Class I MHC mediated antigen processing & presentation	R-HSA-983169	6.209306e-01	0.207
Downstream TCR signaling	R-HSA-202424	6.210751e-01	0.207
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	6.274850e-01	0.202
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.274850e-01	0.202
cGMP effects	R-HSA-418457	6.274850e-01	0.202
Regulation of KIT signaling	R-HSA-1433559	6.274850e-01	0.202
Zinc transporters	R-HSA-435354	6.274850e-01	0.202
P2Y receptors	R-HSA-417957	6.274850e-01	0.202
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.312917e-01	0.200
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.327692e-01	0.199
RAS processing	R-HSA-9648002	6.327692e-01	0.199
Integration of energy metabolism	R-HSA-163685	6.329519e-01	0.199
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	6.360224e-01	0.197
FRS-mediated FGFR4 signaling	R-HSA-5654712	6.425955e-01	0.192
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.425955e-01	0.192
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.425955e-01	0.192
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.425955e-01	0.192
RAF-independent MAPK1/3 activation	R-HSA-112409	6.425955e-01	0.192
Signaling by KIT in disease	R-HSA-9669938	6.425955e-01	0.192
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	6.425955e-01	0.192
Protein ubiquitination	R-HSA-8852135	6.457762e-01	0.190
RNA Polymerase II Transcription	R-HSA-73857	6.465674e-01	0.189
Regulation of CDH1 Function	R-HSA-9764561	6.466468e-01	0.189
FOXO-mediated transcription	R-HSA-9614085	6.474742e-01	0.189
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.512298e-01	0.186
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.548886e-01	0.184
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.548886e-01	0.184
Erythropoietin activates STAT5	R-HSA-9027283	6.548886e-01	0.184
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	6.548886e-01	0.184
Autointegration results in viral DNA circles	R-HSA-177539	6.548886e-01	0.184
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.548886e-01	0.184
Defective CYP11A1 causes AICSR	R-HSA-5579026	6.548886e-01	0.184
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.548886e-01	0.184
Hydrolysis of LPE	R-HSA-1483152	6.548886e-01	0.184
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.548886e-01	0.184
Neurofascin interactions	R-HSA-447043	6.548886e-01	0.184
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.548886e-01	0.184
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.548886e-01	0.184
Signaling by LTK in cancer	R-HSA-9842640	6.548886e-01	0.184
NADPH regeneration	R-HSA-389542	6.548886e-01	0.184
HDL clearance	R-HSA-8964011	6.548886e-01	0.184
Nef and signal transduction	R-HSA-164944	6.548886e-01	0.184
PPARA activates gene expression	R-HSA-1989781	6.562848e-01	0.183
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	6.565250e-01	0.183
G beta:gamma signalling through BTK	R-HSA-8964315	6.565250e-01	0.183
RNA Polymerase III Chain Elongation	R-HSA-73780	6.565250e-01	0.183
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.565250e-01	0.183
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.565250e-01	0.183
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.565250e-01	0.183
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.565250e-01	0.183
MAPK6/MAPK4 signaling	R-HSA-5687128	6.590775e-01	0.181
UCH proteinases	R-HSA-5689603	6.594591e-01	0.181
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	6.620239e-01	0.179
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	6.620239e-01	0.179
Unfolded Protein Response (UPR)	R-HSA-381119	6.634737e-01	0.178
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	6.647460e-01	0.177
Interleukin receptor SHC signaling	R-HSA-912526	6.657086e-01	0.177
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.657086e-01	0.177
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.657086e-01	0.177
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	6.657086e-01	0.177
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	6.657086e-01	0.177
Hh mutants are degraded by ERAD	R-HSA-5362768	6.690895e-01	0.175
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.690895e-01	0.175
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	6.690895e-01	0.175
Cell junction organization	R-HSA-446728	6.701500e-01	0.174
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	6.718161e-01	0.173
Translation of Structural Proteins	R-HSA-9694635	6.728310e-01	0.172
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.744753e-01	0.171
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	6.750893e-01	0.171
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	6.760587e-01	0.170
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.760587e-01	0.170
SARS-CoV-2 Infection	R-HSA-9694516	6.761513e-01	0.170
Peroxisomal protein import	R-HSA-9033241	6.769867e-01	0.169
Signaling by FGFR2 in disease	R-HSA-5655253	6.807361e-01	0.167
Signaling by VEGF	R-HSA-194138	6.822868e-01	0.166
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.837233e-01	0.165
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.837233e-01	0.165
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.837233e-01	0.165
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.837233e-01	0.165
Differentiation of T cells	R-HSA-9945266	6.837233e-01	0.165
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.837233e-01	0.165
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.837233e-01	0.165
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.837233e-01	0.165
Serotonin and melatonin biosynthesis	R-HSA-209931	6.837233e-01	0.165
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	6.863371e-01	0.163
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.863371e-01	0.163
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	6.863371e-01	0.163
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.877119e-01	0.163
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.933764e-01	0.159
RUNX3 regulates WNT signaling	R-HSA-8951430	6.933764e-01	0.159
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.933764e-01	0.159
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.933764e-01	0.159
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.933764e-01	0.159
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.933764e-01	0.159
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.933764e-01	0.159
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.933764e-01	0.159
mRNA Editing: C to U Conversion	R-HSA-72200	6.933764e-01	0.159
PTK6 Expression	R-HSA-8849473	6.933764e-01	0.159
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.933764e-01	0.159
Electron transport from NADPH to Ferredoxin	R-HSA-2395516	6.933764e-01	0.159
DAG1 core M1 glycosylations	R-HSA-8932506	6.933764e-01	0.159
VLDL clearance	R-HSA-8964046	6.933764e-01	0.159
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.933764e-01	0.159
Phase 3 - rapid repolarisation	R-HSA-5576890	6.933764e-01	0.159
Cation-coupled Chloride cotransporters	R-HSA-426117	6.933764e-01	0.159
CHL1 interactions	R-HSA-447041	6.933764e-01	0.159
Maturation of replicase proteins	R-HSA-9694301	6.933764e-01	0.159
Glucagon signaling in metabolic regulation	R-HSA-163359	6.948906e-01	0.158
Vpu mediated degradation of CD4	R-HSA-180534	6.948906e-01	0.158
Activation of NF-kappaB in B cells	R-HSA-1169091	6.962224e-01	0.157
Sensory processing of sound	R-HSA-9659379	6.986123e-01	0.156
Neutrophil degranulation	R-HSA-6798695	6.997098e-01	0.155
Transcriptional regulation by RUNX2	R-HSA-8878166	7.028592e-01	0.153
Viral Messenger RNA Synthesis	R-HSA-168325	7.056367e-01	0.151
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.056367e-01	0.151
Aquaporin-mediated transport	R-HSA-445717	7.056367e-01	0.151
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.086102e-01	0.150
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.091294e-01	0.149
Acetylcholine regulates insulin secretion	R-HSA-399997	7.091294e-01	0.149
Disorders of Developmental Biology	R-HSA-9675151	7.091294e-01	0.149
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	7.109940e-01	0.148
mRNA 3'-end processing	R-HSA-72187	7.111988e-01	0.148
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.111988e-01	0.148
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	7.119343e-01	0.148
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	7.145789e-01	0.146
NoRC negatively regulates rRNA expression	R-HSA-427413	7.145789e-01	0.146
Hedgehog 'on' state	R-HSA-5632684	7.145789e-01	0.146
Metabolism of RNA	R-HSA-8953854	7.150052e-01	0.146
Response of Mtb to phagocytosis	R-HSA-9637690	7.189695e-01	0.143
Influenza Infection	R-HSA-168255	7.194570e-01	0.143
rRNA processing in the nucleus and cytosol	R-HSA-8868773	7.195762e-01	0.143
Amino acids regulate mTORC1	R-HSA-9639288	7.256614e-01	0.139
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	7.271932e-01	0.138
Ion channel transport	R-HSA-983712	7.274629e-01	0.138
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.275740e-01	0.138
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.275740e-01	0.138
FGFR1b ligand binding and activation	R-HSA-190370	7.275740e-01	0.138
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	7.275740e-01	0.138
Signaling by MRAS-complex mutants	R-HSA-9660537	7.275740e-01	0.138
Formation of annular gap junctions	R-HSA-196025	7.275740e-01	0.138
MET receptor recycling	R-HSA-8875656	7.275740e-01	0.138
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	7.275740e-01	0.138
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.275740e-01	0.138
Interleukin-23 signaling	R-HSA-9020933	7.275740e-01	0.138
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	7.275740e-01	0.138
DAG1 core M2 glycosylations	R-HSA-8932504	7.275740e-01	0.138
Activated NTRK2 signals through FYN	R-HSA-9032500	7.275740e-01	0.138
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.301672e-01	0.137
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.301672e-01	0.137
Regulation of Apoptosis	R-HSA-169911	7.301672e-01	0.137
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.328047e-01	0.135
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	7.328047e-01	0.135
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.328047e-01	0.135
Ribosome-associated quality control	R-HSA-9948299	7.388133e-01	0.131
Regulation of insulin secretion	R-HSA-422356	7.388459e-01	0.131
Co-inhibition by PD-1	R-HSA-389948	7.425695e-01	0.129
Triglyceride catabolism	R-HSA-163560	7.466201e-01	0.127
RUNX2 regulates bone development	R-HSA-8941326	7.466201e-01	0.127
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.471490e-01	0.127
EPHA-mediated growth cone collapse	R-HSA-3928663	7.471490e-01	0.127
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.491070e-01	0.125
HDACs deacetylate histones	R-HSA-3214815	7.530414e-01	0.123
G beta:gamma signalling through PLC beta	R-HSA-418217	7.548192e-01	0.122
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.548192e-01	0.122
Presynaptic function of Kainate receptors	R-HSA-500657	7.548192e-01	0.122
Mismatch Repair	R-HSA-5358508	7.548192e-01	0.122
Depolymerization of the Nuclear Lamina	R-HSA-4419969	7.548192e-01	0.122
Nucleotide-like (purinergic) receptors	R-HSA-418038	7.548192e-01	0.122
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	7.548192e-01	0.122
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	7.572307e-01	0.121
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.579593e-01	0.120
Gap junction degradation	R-HSA-190873	7.579593e-01	0.120
Cellular response to mitochondrial stress	R-HSA-9840373	7.579593e-01	0.120
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.579593e-01	0.120
Unwinding of DNA	R-HSA-176974	7.579593e-01	0.120
Interleukin-1 processing	R-HSA-448706	7.579593e-01	0.120
Regulation of signaling by NODAL	R-HSA-1433617	7.579593e-01	0.120
mRNA Editing	R-HSA-75072	7.579593e-01	0.120
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.579593e-01	0.120
Developmental Biology	R-HSA-1266738	7.581833e-01	0.120
Degradation of AXIN	R-HSA-4641257	7.622946e-01	0.118
L1CAM interactions	R-HSA-373760	7.624129e-01	0.118
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.627393e-01	0.118
Protein folding	R-HSA-391251	7.631323e-01	0.117
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.648332e-01	0.116
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.648332e-01	0.116
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.686641e-01	0.114
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.686641e-01	0.114
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.686641e-01	0.114
Assembly of the pre-replicative complex	R-HSA-68867	7.731795e-01	0.112
RNA Polymerase I Promoter Clearance	R-HSA-73854	7.738218e-01	0.111
E2F mediated regulation of DNA replication	R-HSA-113510	7.752488e-01	0.111
STING mediated induction of host immune responses	R-HSA-1834941	7.752488e-01	0.111
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	7.752488e-01	0.111
Synthesis of PC	R-HSA-1483191	7.767751e-01	0.110
Glucagon-type ligand receptors	R-HSA-420092	7.814976e-01	0.107
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.849572e-01	0.105
Folding of actin by CCT/TriC	R-HSA-390450	7.849572e-01	0.105
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	7.849572e-01	0.105
EGFR Transactivation by Gastrin	R-HSA-2179392	7.849572e-01	0.105
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.849572e-01	0.105
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.849572e-01	0.105
2-LTR circle formation	R-HSA-164843	7.849572e-01	0.105
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	7.849572e-01	0.105
Maturation of spike protein	R-HSA-9683686	7.849572e-01	0.105
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.849572e-01	0.105
Serotonin receptors	R-HSA-390666	7.849572e-01	0.105
Intraflagellar transport	R-HSA-5620924	7.897014e-01	0.103
Co-stimulation by CD28	R-HSA-389356	7.897014e-01	0.103
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.941731e-01	0.100
VxPx cargo-targeting to cilium	R-HSA-5620916	7.941731e-01	0.100
Post-chaperonin tubulin folding pathway	R-HSA-389977	7.941731e-01	0.100
Pregnenolone biosynthesis	R-HSA-196108	7.941731e-01	0.100
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	7.941731e-01	0.100
Signaling by NODAL	R-HSA-1181150	7.941731e-01	0.100
RNA Polymerase I Transcription	R-HSA-73864	7.948474e-01	0.100
Mitotic Prophase	R-HSA-68875	7.968916e-01	0.099
Activation of the pre-replicative complex	R-HSA-68962	7.971744e-01	0.098
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.971744e-01	0.098
Chaperonin-mediated protein folding	R-HSA-390466	7.980170e-01	0.098
Extension of Telomeres	R-HSA-180786	8.016957e-01	0.096
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.047919e-01	0.094
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.047919e-01	0.094
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.047919e-01	0.094
Diseases of Immune System	R-HSA-5260271	8.047919e-01	0.094
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.047919e-01	0.094
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.047919e-01	0.094
Generation of second messenger molecules	R-HSA-202433	8.047919e-01	0.094
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.089450e-01	0.092
FGFR2b ligand binding and activation	R-HSA-190377	8.089450e-01	0.092
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.089450e-01	0.092
vRNA Synthesis	R-HSA-192814	8.089450e-01	0.092
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.089450e-01	0.092
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.089450e-01	0.092
Suppression of apoptosis	R-HSA-9635465	8.089450e-01	0.092
Dissolution of Fibrin Clot	R-HSA-75205	8.089450e-01	0.092
COPI-mediated anterograde transport	R-HSA-6807878	8.103244e-01	0.091
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.116736e-01	0.091
ERK/MAPK targets	R-HSA-198753	8.116736e-01	0.091
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.118987e-01	0.090
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.126214e-01	0.090
RAB geranylgeranylation	R-HSA-8873719	8.126214e-01	0.090
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.126214e-01	0.090
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.143772e-01	0.089
Regulation of T cell activation by CD28 family	R-HSA-388841	8.157310e-01	0.088
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.175088e-01	0.088
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.227972e-01	0.085
RNA Polymerase II Transcription Termination	R-HSA-73856	8.230687e-01	0.085
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.232269e-01	0.084
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	8.278324e-01	0.082
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.278324e-01	0.082
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	8.278324e-01	0.082
Synthesis of DNA	R-HSA-69239	8.294392e-01	0.081
Degradation of CRY and PER proteins	R-HSA-9932298	8.295358e-01	0.081
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.302583e-01	0.081
PI3K events in ERBB4 signaling	R-HSA-1250342	8.302583e-01	0.081
Integration of provirus	R-HSA-162592	8.302583e-01	0.081
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.302583e-01	0.081
Plasmalogen biosynthesis	R-HSA-75896	8.302583e-01	0.081
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.302583e-01	0.081
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	8.302583e-01	0.081
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	8.302583e-01	0.081
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.302583e-01	0.081
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.302583e-01	0.081
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.302583e-01	0.081
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.302583e-01	0.081
Signaling by PDGF	R-HSA-186797	8.330479e-01	0.079
tRNA processing in the nucleus	R-HSA-6784531	8.330479e-01	0.079
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.334856e-01	0.079
Cytoprotection by HMOX1	R-HSA-9707564	8.409554e-01	0.075
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.425700e-01	0.074
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	8.427311e-01	0.074
WNT ligand biogenesis and trafficking	R-HSA-3238698	8.427311e-01	0.074
LDL clearance	R-HSA-8964038	8.427311e-01	0.074
Meiotic synapsis	R-HSA-1221632	8.457238e-01	0.073
GRB2 events in EGFR signaling	R-HSA-179812	8.491950e-01	0.071
Diseases associated with surfactant metabolism	R-HSA-5687613	8.491950e-01	0.071
Polymerase switching	R-HSA-69091	8.491950e-01	0.071
Leading Strand Synthesis	R-HSA-69109	8.491950e-01	0.071
Disorders of Nervous System Development	R-HSA-9697154	8.491950e-01	0.071
Pervasive developmental disorders	R-HSA-9005895	8.491950e-01	0.071
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	8.491950e-01	0.071
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.491950e-01	0.071
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.493085e-01	0.071
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.493085e-01	0.071
Signaling by NOTCH4	R-HSA-9013694	8.497735e-01	0.071
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.507331e-01	0.070
Miscellaneous transport and binding events	R-HSA-5223345	8.507331e-01	0.070
Translation initiation complex formation	R-HSA-72649	8.553082e-01	0.068
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.564496e-01	0.067
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	8.564496e-01	0.067
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.564496e-01	0.067
Carnitine shuttle	R-HSA-200425	8.564496e-01	0.067
Adherens junctions interactions	R-HSA-418990	8.588384e-01	0.066
Cellular response to hypoxia	R-HSA-1234174	8.602906e-01	0.065
Surfactant metabolism	R-HSA-5683826	8.617110e-01	0.065
RMTs methylate histone arginines	R-HSA-3214858	8.617110e-01	0.065
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.620288e-01	0.064
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.620288e-01	0.064
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.620288e-01	0.064
G alpha (z) signalling events	R-HSA-418597	8.643907e-01	0.063
Acetylcholine binding and downstream events	R-HSA-181431	8.660201e-01	0.062
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	8.660201e-01	0.062
Adenylate cyclase activating pathway	R-HSA-170660	8.660201e-01	0.062
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	8.660201e-01	0.062
FGFR2c ligand binding and activation	R-HSA-190375	8.660201e-01	0.062
FGFR1c ligand binding and activation	R-HSA-190373	8.660201e-01	0.062
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.660201e-01	0.062
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.660201e-01	0.062
FGFR4 ligand binding and activation	R-HSA-190322	8.660201e-01	0.062
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.660201e-01	0.062
Chylomicron remodeling	R-HSA-8963901	8.660201e-01	0.062
Mtb iron assimilation by chelation	R-HSA-1222449	8.660201e-01	0.062
FGFR3 mutant receptor activation	R-HSA-2033514	8.660201e-01	0.062
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	8.660201e-01	0.062
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.660201e-01	0.062
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.660201e-01	0.062
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	8.690657e-01	0.061
Complex III assembly	R-HSA-9865881	8.690657e-01	0.061
CD209 (DC-SIGN) signaling	R-HSA-5621575	8.690657e-01	0.061
TNFs bind their physiological receptors	R-HSA-5669034	8.690657e-01	0.061
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.712153e-01	0.060
Ribosomal scanning and start codon recognition	R-HSA-72702	8.729886e-01	0.059
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	8.729886e-01	0.059
ER to Golgi Anterograde Transport	R-HSA-199977	8.755005e-01	0.058
SLC-mediated transport of amino acids	R-HSA-9958863	8.763305e-01	0.057
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	8.769568e-01	0.057
Activation of HOX genes during differentiation	R-HSA-5619507	8.769568e-01	0.057
Pyruvate metabolism	R-HSA-70268	8.784585e-01	0.056
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.801508e-01	0.055
Nuclear Receptor transcription pathway	R-HSA-383280	8.804750e-01	0.055
PCP/CE pathway	R-HSA-4086400	8.804750e-01	0.055
ABC transporter disorders	R-HSA-5619084	8.804750e-01	0.055
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.806547e-01	0.055
Tight junction interactions	R-HSA-420029	8.806547e-01	0.055
VEGFR2 mediated cell proliferation	R-HSA-5218921	8.806547e-01	0.055
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.806547e-01	0.055
Removal of the Flap Intermediate	R-HSA-69166	8.809690e-01	0.055
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.809690e-01	0.055
Retrograde neurotrophin signalling	R-HSA-177504	8.809690e-01	0.055
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.809690e-01	0.055
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.809690e-01	0.055
FGFR3c ligand binding and activation	R-HSA-190372	8.809690e-01	0.055
Transport of fatty acids	R-HSA-804914	8.809690e-01	0.055
Hydrolysis of LPC	R-HSA-1483115	8.809690e-01	0.055
Physiological factors	R-HSA-5578768	8.809690e-01	0.055
Prolactin receptor signaling	R-HSA-1170546	8.809690e-01	0.055
HDL assembly	R-HSA-8963896	8.809690e-01	0.055
Signal regulatory protein family interactions	R-HSA-391160	8.809690e-01	0.055
FGFR2 mutant receptor activation	R-HSA-1839126	8.823846e-01	0.054
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	8.837532e-01	0.054
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.837532e-01	0.054
Recycling pathway of L1	R-HSA-437239	8.885428e-01	0.051
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.888017e-01	0.051
Potential therapeutics for SARS	R-HSA-9679191	8.905817e-01	0.050
ER-Phagosome pathway	R-HSA-1236974	8.912675e-01	0.050
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.912885e-01	0.050
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.912885e-01	0.050
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.912885e-01	0.050
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.912885e-01	0.050
PKR-mediated signaling	R-HSA-9833482	8.937513e-01	0.049
Erythropoietin activates RAS	R-HSA-9027284	8.942507e-01	0.049
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.942507e-01	0.049
SHC1 events in EGFR signaling	R-HSA-180336	8.942507e-01	0.049
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.942507e-01	0.049
Processive synthesis on the lagging strand	R-HSA-69183	8.942507e-01	0.049
Telomere C-strand synthesis initiation	R-HSA-174430	8.942507e-01	0.049
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.942507e-01	0.049
FGFR3 ligand binding and activation	R-HSA-190239	8.942507e-01	0.049
Protein lipoylation	R-HSA-9857492	8.942507e-01	0.049
Other semaphorin interactions	R-HSA-416700	8.942507e-01	0.049
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.942507e-01	0.049
Amino acid transport across the plasma membrane	R-HSA-352230	8.960527e-01	0.048
Adaptive Immune System	R-HSA-1280218	8.963764e-01	0.048
GPER1 signaling	R-HSA-9634597	8.964163e-01	0.047
COPII-mediated vesicle transport	R-HSA-204005	8.974719e-01	0.047
Amyloid fiber formation	R-HSA-977225	8.999085e-01	0.046
Cristae formation	R-HSA-8949613	9.010361e-01	0.045
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.010361e-01	0.045
C-type lectin receptors (CLRs)	R-HSA-5621481	9.014208e-01	0.045
Gap junction trafficking and regulation	R-HSA-157858	9.037960e-01	0.044
DNA Replication Pre-Initiation	R-HSA-69002	9.048811e-01	0.043
Defective GALNT3 causes HFTC	R-HSA-5083625	9.060510e-01	0.043
Class I peroxisomal membrane protein import	R-HSA-9603798	9.060510e-01	0.043
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.060510e-01	0.043
Activation of SMO	R-HSA-5635838	9.060510e-01	0.043
Attachment and Entry	R-HSA-9678110	9.060510e-01	0.043
SARS-CoV Infections	R-HSA-9679506	9.065471e-01	0.043
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.079105e-01	0.042
Pentose phosphate pathway	R-HSA-71336	9.079105e-01	0.042
Platelet degranulation	R-HSA-114608	9.082237e-01	0.042
Collagen degradation	R-HSA-1442490	9.093336e-01	0.041
Transcriptional regulation by small RNAs	R-HSA-5578749	9.097800e-01	0.041
Signaling by NOTCH	R-HSA-157118	9.098512e-01	0.041
Insulin receptor recycling	R-HSA-77387	9.099627e-01	0.041
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.099627e-01	0.041
Beta-catenin independent WNT signaling	R-HSA-3858494	9.123077e-01	0.040
Cell-cell junction organization	R-HSA-421270	9.144265e-01	0.039
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.152327e-01	0.038
NCAM signaling for neurite out-growth	R-HSA-375165	9.153988e-01	0.038
Ca2+ pathway	R-HSA-4086398	9.154393e-01	0.038
Diseases of carbohydrate metabolism	R-HSA-5663084	9.154393e-01	0.038
Regulation of endogenous retroelements	R-HSA-9842860	9.161097e-01	0.038
Processing of Intronless Pre-mRNAs	R-HSA-77595	9.165353e-01	0.038
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.165353e-01	0.038
G beta:gamma signalling through CDC42	R-HSA-8964616	9.165353e-01	0.038
Phase 2 - plateau phase	R-HSA-5576893	9.165353e-01	0.038
Galactose catabolism	R-HSA-70370	9.165353e-01	0.038
Coenzyme A biosynthesis	R-HSA-196783	9.165353e-01	0.038
tRNA modification in the mitochondrion	R-HSA-6787450	9.165353e-01	0.038
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.171714e-01	0.038
Platelet calcium homeostasis	R-HSA-418360	9.181301e-01	0.037
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.220207e-01	0.035
RNA Polymerase I Promoter Escape	R-HSA-73772	9.232144e-01	0.035
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.236873e-01	0.034
Platelet activation, signaling and aggregation	R-HSA-76002	9.255922e-01	0.034
DAP12 signaling	R-HSA-2424491	9.255966e-01	0.034
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.258359e-01	0.033
Iron uptake and transport	R-HSA-917937	9.258359e-01	0.033
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.258500e-01	0.033
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.258500e-01	0.033
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.258500e-01	0.033
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.258500e-01	0.033
Regulation of NPAS4 gene expression	R-HSA-9768759	9.258500e-01	0.033
Catecholamine biosynthesis	R-HSA-209905	9.258500e-01	0.033
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.258500e-01	0.033
Uptake and function of anthrax toxins	R-HSA-5210891	9.258500e-01	0.033
Ion transport by P-type ATPases	R-HSA-936837	9.264655e-01	0.033
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.283076e-01	0.032
Intra-Golgi traffic	R-HSA-6811438	9.283076e-01	0.032
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.283076e-01	0.032
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	9.288581e-01	0.032
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.288581e-01	0.032
Phospholipid metabolism	R-HSA-1483257	9.303034e-01	0.031
Molecules associated with elastic fibres	R-HSA-2129379	9.324169e-01	0.030
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.324169e-01	0.030
Cargo concentration in the ER	R-HSA-5694530	9.324169e-01	0.030
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.341245e-01	0.030
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.341258e-01	0.030
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.341258e-01	0.030
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.341258e-01	0.030
Activated point mutants of FGFR2	R-HSA-2033519	9.341258e-01	0.030
FGFR1 ligand binding and activation	R-HSA-190242	9.341258e-01	0.030
Transport of connexons to the plasma membrane	R-HSA-190872	9.341258e-01	0.030
Platelet sensitization by LDL	R-HSA-432142	9.341258e-01	0.030
Nephron development	R-HSA-9831926	9.341258e-01	0.030
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.356193e-01	0.029
G alpha (s) signalling events	R-HSA-418555	9.365375e-01	0.028
DNA strand elongation	R-HSA-69190	9.386421e-01	0.027
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.386421e-01	0.027
Protein localization	R-HSA-9609507	9.402812e-01	0.027
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.414783e-01	0.026
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.414783e-01	0.026
Pyrimidine biosynthesis	R-HSA-500753	9.414783e-01	0.026
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.414783e-01	0.026
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.414783e-01	0.026
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.414783e-01	0.026
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.414783e-01	0.026
Other interleukin signaling	R-HSA-449836	9.414783e-01	0.026
rRNA processing	R-HSA-72312	9.426177e-01	0.026
Antigen processing-Cross presentation	R-HSA-1236975	9.438984e-01	0.025
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.443201e-01	0.025
Gap junction trafficking	R-HSA-190828	9.444753e-01	0.025
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.480105e-01	0.023
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.480105e-01	0.023
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.480105e-01	0.023
Co-inhibition by CTLA4	R-HSA-389513	9.480105e-01	0.023
Acyl chain remodelling of PI	R-HSA-1482922	9.480105e-01	0.023
Acyl chain remodelling of PC	R-HSA-1482788	9.494955e-01	0.023
ABC-family proteins mediated transport	R-HSA-382556	9.497549e-01	0.022
Condensation of Prophase Chromosomes	R-HSA-2299718	9.532969e-01	0.021
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.532969e-01	0.021
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.538140e-01	0.021
G-protein activation	R-HSA-202040	9.538140e-01	0.021
FGFR2 ligand binding and activation	R-HSA-190241	9.538140e-01	0.021
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.538140e-01	0.021
Lagging Strand Synthesis	R-HSA-69186	9.538140e-01	0.021
Signalling to RAS	R-HSA-167044	9.538140e-01	0.021
Early Phase of HIV Life Cycle	R-HSA-162594	9.538140e-01	0.021
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.538140e-01	0.021
Gap junction assembly	R-HSA-190861	9.542097e-01	0.020
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.542097e-01	0.020
Triglyceride metabolism	R-HSA-8979227	9.555149e-01	0.020
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.557321e-01	0.020
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.569997e-01	0.019
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.584468e-01	0.018
Acyl chain remodelling of PE	R-HSA-1482839	9.585011e-01	0.018
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.589100e-01	0.018
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.589699e-01	0.018
Androgen biosynthesis	R-HSA-193048	9.589699e-01	0.018
Molybdenum cofactor biosynthesis	R-HSA-947581	9.589699e-01	0.018
Serine metabolism	R-HSA-977347	9.589699e-01	0.018
Glucocorticoid biosynthesis	R-HSA-194002	9.589699e-01	0.018
Glutathione synthesis and recycling	R-HSA-174403	9.589699e-01	0.018
Attachment and Entry	R-HSA-9694614	9.589699e-01	0.018
Gluconeogenesis	R-HSA-70263	9.607942e-01	0.017
Neddylation	R-HSA-8951664	9.611952e-01	0.017
Mitochondrial protein degradation	R-HSA-9837999	9.615076e-01	0.017
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.635505e-01	0.016
Cellular hexose transport	R-HSA-189200	9.635505e-01	0.016
Mitochondrial protein import	R-HSA-1268020	9.650614e-01	0.015
DNA Replication	R-HSA-69306	9.652138e-01	0.015
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.654624e-01	0.015
Cleavage of the damaged purine	R-HSA-110331	9.659554e-01	0.015
SLC-mediated transport of organic cations	R-HSA-549127	9.659554e-01	0.015
NCAM1 interactions	R-HSA-419037	9.659554e-01	0.015
Collagen chain trimerization	R-HSA-8948216	9.659554e-01	0.015
Selenoamino acid metabolism	R-HSA-2408522	9.660623e-01	0.015
Termination of O-glycan biosynthesis	R-HSA-977068	9.676200e-01	0.014
Free fatty acids regulate insulin secretion	R-HSA-400451	9.676200e-01	0.014
Formation of the ureteric bud	R-HSA-9830674	9.676200e-01	0.014
Organic anion transport by SLCO transporters	R-HSA-879518	9.676200e-01	0.014
ABC transporters in lipid homeostasis	R-HSA-1369062	9.676200e-01	0.014
Platelet homeostasis	R-HSA-418346	9.678623e-01	0.014
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.691817e-01	0.014
Depurination	R-HSA-73927	9.691817e-01	0.014
Elastic fibre formation	R-HSA-1566948	9.691817e-01	0.014
The phototransduction cascade	R-HSA-2514856	9.699491e-01	0.013
Telomere Maintenance	R-HSA-157579	9.706749e-01	0.013
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	9.712354e-01	0.013
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.712354e-01	0.013
Thromboxane signalling through TP receptor	R-HSA-428930	9.712354e-01	0.013
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.712354e-01	0.013
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.712354e-01	0.013
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.712354e-01	0.013
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.712354e-01	0.013
Synthesis of dolichyl-phosphate	R-HSA-446199	9.712354e-01	0.013
Mitochondrial RNA degradation	R-HSA-9836573	9.712354e-01	0.013
Plasma lipoprotein assembly	R-HSA-8963898	9.712354e-01	0.013
Interleukin-10 signaling	R-HSA-6783783	9.739694e-01	0.011
Laminin interactions	R-HSA-3000157	9.744472e-01	0.011
Acyl chain remodelling of PS	R-HSA-1482801	9.744472e-01	0.011
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.744472e-01	0.011
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.747727e-01	0.011
Base Excision Repair	R-HSA-73884	9.757883e-01	0.011
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.770546e-01	0.010
Maturation of spike protein	R-HSA-9694548	9.771870e-01	0.010
Urea cycle	R-HSA-70635	9.773006e-01	0.010
Chromosome Maintenance	R-HSA-73886	9.778612e-01	0.010
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.798355e-01	0.009
RNA Polymerase I Promoter Opening	R-HSA-73728	9.798355e-01	0.009
Packaging Of Telomere Ends	R-HSA-171306	9.798355e-01	0.009
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.798355e-01	0.009
Synthesis of PE	R-HSA-1483213	9.798355e-01	0.009
Signaling by BMP	R-HSA-201451	9.798355e-01	0.009
Maturation of hRSV A proteins	R-HSA-9828806	9.798355e-01	0.009
Metabolism of amine-derived hormones	R-HSA-209776	9.808695e-01	0.008
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.808695e-01	0.008
Cytosolic tRNA aminoacylation	R-HSA-379716	9.813623e-01	0.008
Cleavage of the damaged pyrimidine	R-HSA-110329	9.813623e-01	0.008
Depyrimidination	R-HSA-73928	9.813623e-01	0.008
HCMV Early Events	R-HSA-9609690	9.820078e-01	0.008
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.820096e-01	0.008
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	9.820875e-01	0.008
Pyrimidine salvage	R-HSA-73614	9.820875e-01	0.008
FCERI mediated NF-kB activation	R-HSA-2871837	9.834062e-01	0.007
DNA methylation	R-HSA-5334118	9.840881e-01	0.007
Regulation of gene expression in beta cells	R-HSA-210745	9.840881e-01	0.007
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.840881e-01	0.007
SLC transporter disorders	R-HSA-5619102	9.842726e-01	0.007
DAP12 interactions	R-HSA-2172127	9.847917e-01	0.007
Proteasome assembly	R-HSA-9907900	9.847917e-01	0.007
Immune System	R-HSA-168256	9.853250e-01	0.006
Regulation of beta-cell development	R-HSA-186712	9.854767e-01	0.006
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.854767e-01	0.006
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.858653e-01	0.006
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.858653e-01	0.006
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.858653e-01	0.006
Nucleosome assembly	R-HSA-774815	9.862678e-01	0.006
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	9.862678e-01	0.006
G alpha (q) signalling events	R-HSA-416476	9.867031e-01	0.006
Signaling by Retinoic Acid	R-HSA-5362517	9.867604e-01	0.006
ROS and RNS production in phagocytes	R-HSA-1222556	9.872098e-01	0.006
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.874442e-01	0.005
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.874442e-01	0.005
Formation of paraxial mesoderm	R-HSA-9793380	9.879347e-01	0.005
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.888131e-01	0.005
DAG1 glycosylations	R-HSA-8931838	9.888467e-01	0.005
Disorders of transmembrane transporters	R-HSA-5619115	9.891479e-01	0.005
Defective B3GALTL causes PpS	R-HSA-5083635	9.900927e-01	0.004
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.900927e-01	0.004
HCMV Infection	R-HSA-9609646	9.907289e-01	0.004
Neurotransmitter release cycle	R-HSA-112310	9.907869e-01	0.004
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.911995e-01	0.004
Heme degradation	R-HSA-189483	9.911995e-01	0.004
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.917174e-01	0.004
eNOS activation	R-HSA-203615	9.921828e-01	0.003
Signal amplification	R-HSA-392518	9.921828e-01	0.003
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.921828e-01	0.003
RA biosynthesis pathway	R-HSA-5365859	9.921828e-01	0.003
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.924531e-01	0.003
HCMV Late Events	R-HSA-9610379	9.927762e-01	0.003
Transferrin endocytosis and recycling	R-HSA-917977	9.930562e-01	0.003
Transport to the Golgi and subsequent modification	R-HSA-948021	9.931091e-01	0.003
Metabolism of steroid hormones	R-HSA-196071	9.931353e-01	0.003
Uptake and actions of bacterial toxins	R-HSA-5339562	9.933282e-01	0.003
O-linked glycosylation of mucins	R-HSA-913709	9.937576e-01	0.003
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.937576e-01	0.003
PRC2 methylates histones and DNA	R-HSA-212300	9.938321e-01	0.003
Lysosome Vesicle Biogenesis	R-HSA-432720	9.938321e-01	0.003
Collagen formation	R-HSA-1474290	9.939170e-01	0.003
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.944069e-01	0.002
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.945213e-01	0.002
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.945213e-01	0.002
Gene Silencing by RNA	R-HSA-211000	9.948173e-01	0.002
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.948424e-01	0.002
Viral Infection Pathways	R-HSA-9824446	9.951204e-01	0.002
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.951336e-01	0.002
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.956774e-01	0.002
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.956774e-01	0.002
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.956774e-01	0.002
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.957432e-01	0.002
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.959344e-01	0.002
Post-translational protein phosphorylation	R-HSA-8957275	9.960142e-01	0.002
GPCR downstream signalling	R-HSA-388396	9.964332e-01	0.002
Citric acid cycle (TCA cycle)	R-HSA-71403	9.968143e-01	0.001
tRNA Aminoacylation	R-HSA-379724	9.971145e-01	0.001
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.972993e-01	0.001
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.973095e-01	0.001
Defective pyroptosis	R-HSA-9710421	9.976103e-01	0.001
Pyrimidine catabolism	R-HSA-73621	9.976103e-01	0.001
Integrin cell surface interactions	R-HSA-216083	9.976211e-01	0.001
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.978427e-01	0.001
Somitogenesis	R-HSA-9824272	9.981148e-01	0.001
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.983255e-01	0.001
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.983255e-01	0.001
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.985128e-01	0.001
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.985128e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.985727e-01	0.001
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.986163e-01	0.001
Nicotinate metabolism	R-HSA-196807	9.986273e-01	0.001
Plasma lipoprotein remodeling	R-HSA-8963899	9.986791e-01	0.001
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	9.986791e-01	0.001
tRNA processing	R-HSA-72306	9.988359e-01	0.001
FCERI mediated MAPK activation	R-HSA-2871796	9.989230e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.989275e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.989580e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.990039e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.991052e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.991052e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.991052e-01	0.000
Nucleotide biosynthesis	R-HSA-8956320	9.992700e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.993435e-01	0.000
Hemostasis	R-HSA-109582	9.994772e-01	0.000
Digestion	R-HSA-8935690	9.994886e-01	0.000
Dectin-2 family	R-HSA-5621480	9.995458e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.995790e-01	0.000
Glutathione conjugation	R-HSA-156590	9.996819e-01	0.000
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.996822e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.996958e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.997073e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.997073e-01	0.000
Endogenous sterols	R-HSA-211976	9.997175e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.997175e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.997497e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.997612e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.997772e-01	0.000
Digestion and absorption	R-HSA-8963743	9.997772e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.997843e-01	0.000
Innate Immune System	R-HSA-168249	9.997935e-01	0.000
Parasite infection	R-HSA-9664407	9.997958e-01	0.000
Leishmania phagocytosis	R-HSA-9664417	9.997958e-01	0.000
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.997958e-01	0.000
Signaling by GPCR	R-HSA-372790	9.997992e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.998021e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.998021e-01	0.000
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.998132e-01	0.000
Leishmania infection	R-HSA-9658195	9.998235e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.998235e-01	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.998243e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.998337e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.998347e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.998568e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998614e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.998834e-01	0.000
Translation	R-HSA-72766	9.999061e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.999138e-01	0.000
Purine catabolism	R-HSA-74259	9.999235e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999304e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999319e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999373e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.999396e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999488e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999520e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999558e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999625e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999672e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999672e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999697e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999754e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999762e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999816e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999879e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999879e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999898e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999952e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999955e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999967e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999974e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999975e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999981e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999988e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999990e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999992e-01	0.000
Transport of small molecules	R-HSA-382551	9.999995e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999995e-01	0.000
Keratinization	R-HSA-6805567	9.999997e-01	0.000
Initial triggering of complement	R-HSA-166663	9.999997e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999998e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999999e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999999e-01	0.000
Complement cascade	R-HSA-166658	9.999999e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	8.076873e-13	12.093
Cell Cycle, Mitotic	R-HSA-69278	1.839640e-11	10.735
M Phase	R-HSA-68886	1.127503e-08	7.948
Cell Cycle Checkpoints	R-HSA-69620	5.644948e-08	7.248
Chromatin organization	R-HSA-4839726	9.158503e-08	7.038
DNA Double-Strand Break Repair	R-HSA-5693532	2.894251e-07	6.538
Chromatin modifying enzymes	R-HSA-3247509	3.475694e-07	6.459
Homology Directed Repair	R-HSA-5693538	4.194508e-07	6.377
DNA Repair	R-HSA-73894	5.596460e-07	6.252
G2/M Transition	R-HSA-69275	1.055307e-06	5.977
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.303415e-06	5.885
Mitotic G2-G2/M phases	R-HSA-453274	1.365258e-06	5.865
Cellular response to heat stress	R-HSA-3371556	1.834611e-06	5.736
G2/M Checkpoints	R-HSA-69481	2.160028e-06	5.666
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.892310e-06	5.539
Processing of DNA double-strand break ends	R-HSA-5693607	4.956872e-06	5.305
Mitotic Prometaphase	R-HSA-68877	5.573425e-06	5.254
HSF1-dependent transactivation	R-HSA-3371571	7.441266e-06	5.128
Separation of Sister Chromatids	R-HSA-2467813	7.495052e-06	5.125
DNA Damage Recognition in GG-NER	R-HSA-5696394	8.245013e-06	5.084
DNA Double Strand Break Response	R-HSA-5693606	7.982602e-06	5.098
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.228297e-05	4.911
Cellular Senescence	R-HSA-2559583	1.220512e-05	4.913
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.617320e-05	4.791
Signaling by ALK in cancer	R-HSA-9700206	1.617320e-05	4.791
Mitotic Anaphase	R-HSA-68882	1.811984e-05	4.742
HSF1 activation	R-HSA-3371511	1.965541e-05	4.707
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.009968e-05	4.697
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.743799e-05	4.562
G2/M DNA damage checkpoint	R-HSA-69473	3.139589e-05	4.503
Metabolism of RNA	R-HSA-8953854	3.301980e-05	4.481
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.657203e-05	4.437
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.081140e-05	4.389
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	5.215723e-05	4.283
Attenuation phase	R-HSA-3371568	5.557034e-05	4.255
Cellular responses to stress	R-HSA-2262752	5.997817e-05	4.222
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.504301e-05	4.187
Nucleotide Excision Repair	R-HSA-5696398	7.303882e-05	4.136
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	7.821342e-05	4.107
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.636134e-05	4.016
Protein ubiquitination	R-HSA-8852135	1.027452e-04	3.988
Cell junction organization	R-HSA-446728	1.134062e-04	3.945
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.178430e-04	3.929
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.182953e-04	3.927
Epigenetic regulation of gene expression	R-HSA-212165	1.241444e-04	3.906
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.403061e-04	3.853
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.479396e-04	3.830
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.673558e-04	3.776
Aggrephagy	R-HSA-9646399	1.861519e-04	3.730
Cellular responses to stimuli	R-HSA-8953897	1.892389e-04	3.723
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.977787e-04	3.704
Regulation of TP53 Activity	R-HSA-5633007	2.108242e-04	3.676
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	2.278217e-04	3.642
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.278217e-04	3.642
Cell-Cell communication	R-HSA-1500931	2.218929e-04	3.654
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.545273e-04	3.594
Estrogen-dependent gene expression	R-HSA-9018519	2.612905e-04	3.583
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.893556e-04	3.539
DNA Replication Pre-Initiation	R-HSA-69002	2.893556e-04	3.539
Mitotic Prophase	R-HSA-68875	2.888715e-04	3.539
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.093598e-04	3.510
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.175486e-04	3.498
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.859393e-04	3.413
Negative regulation of MET activity	R-HSA-6807004	3.898302e-04	3.409
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.255163e-04	3.371
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.255163e-04	3.371
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.249819e-04	3.372
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	5.151010e-04	3.288
Josephin domain DUBs	R-HSA-5689877	5.240147e-04	3.281
Oxidative Stress Induced Senescence	R-HSA-2559580	5.355824e-04	3.271
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.911288e-04	3.228
Deubiquitination	R-HSA-5688426	5.860993e-04	3.232
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	7.462311e-04	3.127
Assembly of the pre-replicative complex	R-HSA-68867	7.735229e-04	3.112
Regulation of PTEN localization	R-HSA-8948747	7.479334e-04	3.126
Apoptotic execution phase	R-HSA-75153	7.678824e-04	3.115
Diseases of programmed cell death	R-HSA-9645723	8.167904e-04	3.088
HATs acetylate histones	R-HSA-3214847	8.236045e-04	3.084
Chaperone Mediated Autophagy	R-HSA-9613829	8.722394e-04	3.059
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	9.250559e-04	3.034
FLT3 signaling by CBL mutants	R-HSA-9706377	9.580146e-04	3.019
Cell-extracellular matrix interactions	R-HSA-446353	1.050626e-03	2.979
Adherens junctions interactions	R-HSA-418990	1.014876e-03	2.994
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.167629e-03	2.933
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.147250e-03	2.940
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.114052e-03	2.953
Regulation of endogenous retroelements	R-HSA-9842860	1.174766e-03	2.930
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.225453e-03	2.912
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.521666e-03	2.818
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.588239e-03	2.799
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.715650e-03	2.766
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.730409e-03	2.762
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.839111e-03	2.735
Downregulation of ERBB2 signaling	R-HSA-8863795	1.787240e-03	2.748
Selective autophagy	R-HSA-9663891	1.839111e-03	2.735
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.999668e-03	2.699
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.999668e-03	2.699
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.999668e-03	2.699
SWI/SNF chromatin remodelers	R-HSA-9932451	1.926581e-03	2.715
ATP-dependent chromatin remodelers	R-HSA-9932444	1.926581e-03	2.715
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.953471e-03	2.709
S Phase	R-HSA-69242	1.902614e-03	2.721
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.966719e-03	2.706
PKMTs methylate histone lysines	R-HSA-3214841	2.071695e-03	2.684
Cell-cell junction organization	R-HSA-421270	2.193351e-03	2.659
EGFR downregulation	R-HSA-182971	2.202266e-03	2.657
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.399698e-03	2.620
Recycling pathway of L1	R-HSA-437239	2.490390e-03	2.604
G1/S Transition	R-HSA-69206	2.336824e-03	2.631
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.564184e-03	2.591
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.590257e-03	2.587
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.777767e-03	2.556
rRNA processing in the nucleus and cytosol	R-HSA-8868773	2.800677e-03	2.553
DNA Replication	R-HSA-69306	2.932181e-03	2.533
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.266489e-03	2.486
Transport of connexons to the plasma membrane	R-HSA-190872	3.378748e-03	2.471
Gene expression (Transcription)	R-HSA-74160	3.544904e-03	2.450
ISG15 antiviral mechanism	R-HSA-1169408	3.664916e-03	2.436
Signaling by EGFR	R-HSA-177929	3.815453e-03	2.418
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.836081e-03	2.416
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.850188e-03	2.415
Translesion Synthesis by POLH	R-HSA-110320	4.341687e-03	2.362
Mitotic Spindle Checkpoint	R-HSA-69618	4.117032e-03	2.385
Spry regulation of FGF signaling	R-HSA-1295596	4.378851e-03	2.359
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	4.378851e-03	2.359
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	4.378851e-03	2.359
Cohesin Loading onto Chromatin	R-HSA-2470946	4.416459e-03	2.355
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.765526e-03	2.322
Inhibition of DNA recombination at telomere	R-HSA-9670095	4.765526e-03	2.322
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.765526e-03	2.322
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	4.708562e-03	2.327
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.041166e-03	2.297
RNA Polymerase I Promoter Escape	R-HSA-73772	5.267359e-03	2.278
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.014809e-03	2.300
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.014809e-03	2.300
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.369500e-03	2.270
RNA Polymerase I Transcription	R-HSA-73864	5.221003e-03	2.282
NoRC negatively regulates rRNA expression	R-HSA-427413	5.009804e-03	2.300
Meiosis	R-HSA-1500620	5.373571e-03	2.270
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	5.041166e-03	2.297
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	5.369500e-03	2.270
Condensation of Prophase Chromosomes	R-HSA-2299718	5.469325e-03	2.262
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.502868e-03	2.259
Transcriptional regulation by small RNAs	R-HSA-5578749	5.643722e-03	2.248
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.536098e-03	2.185
Meiotic synapsis	R-HSA-1221632	6.045773e-03	2.219
Eukaryotic Translation Initiation	R-HSA-72613	6.579229e-03	2.182
Cap-dependent Translation Initiation	R-HSA-72737	6.579229e-03	2.182
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.531499e-03	2.185
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.074457e-03	2.216
ESR-mediated signaling	R-HSA-8939211	6.420098e-03	2.192
Apoptosis	R-HSA-109581	5.990893e-03	2.223
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.536098e-03	2.185
PKR-mediated signaling	R-HSA-9833482	6.531499e-03	2.185
PRC2 methylates histones and DNA	R-HSA-212300	6.614472e-03	2.180
Regulation of TP53 Degradation	R-HSA-6804757	6.614472e-03	2.180
Autophagy	R-HSA-9612973	6.672265e-03	2.176
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.852388e-03	2.164
Translation initiation complex formation	R-HSA-72649	6.913714e-03	2.160
Axon guidance	R-HSA-422475	7.211597e-03	2.142
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	8.961499e-03	2.048
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	8.961499e-03	2.048
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	8.961499e-03	2.048
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	8.961499e-03	2.048
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	8.961499e-03	2.048
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	8.961499e-03	2.048
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	8.961499e-03	2.048
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	8.961499e-03	2.048
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	8.961499e-03	2.048
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	8.961499e-03	2.048
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	8.961499e-03	2.048
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.064524e-03	2.043
Packaging Of Telomere Ends	R-HSA-171306	9.064524e-03	2.043
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.878155e-03	2.104
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.946258e-03	2.048
Ribosomal scanning and start codon recognition	R-HSA-72702	8.946258e-03	2.048
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.946258e-03	2.048
RNA Polymerase II Transcription Termination	R-HSA-73856	7.369589e-03	2.133
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	8.097253e-03	2.092
Chaperonin-mediated protein folding	R-HSA-390466	7.383521e-03	2.132
Signaling by EGFR in Cancer	R-HSA-1643713	7.520568e-03	2.124
UCH proteinases	R-HSA-5689603	8.862694e-03	2.052
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.862694e-03	2.052
Clathrin-mediated endocytosis	R-HSA-8856828	7.670163e-03	2.115
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	9.064524e-03	2.043
Defective pyroptosis	R-HSA-9710421	8.771225e-03	2.057
Membrane Trafficking	R-HSA-199991	7.968313e-03	2.099
Listeria monocytogenes entry into host cells	R-HSA-8876384	8.518802e-03	2.070
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	8.518802e-03	2.070
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.442500e-03	2.128
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.442500e-03	2.128
Gene Silencing by RNA	R-HSA-211000	8.841619e-03	2.053
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.206484e-03	2.036
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	9.206484e-03	2.036
Cilium Assembly	R-HSA-5617833	9.345030e-03	2.029
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	9.378936e-03	2.028
Loss of Nlp from mitotic centrosomes	R-HSA-380259	9.378936e-03	2.028
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.659559e-03	2.015
Programmed Cell Death	R-HSA-5357801	9.715194e-03	2.013
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.821915e-03	2.008
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	9.821915e-03	2.008
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	9.951961e-03	2.002
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	9.963828e-03	2.002
Chromosome Maintenance	R-HSA-73886	1.006821e-02	1.997
Nuclear Envelope Breakdown	R-HSA-2980766	1.012535e-02	1.995
Negative regulation of FGFR3 signaling	R-HSA-5654732	1.083699e-02	1.965
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.054735e-02	1.977
Nucleosome assembly	R-HSA-774815	1.157248e-02	1.937
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.157248e-02	1.937
Transcriptional Regulation by E2F6	R-HSA-8953750	1.054735e-02	1.977
Fanconi Anemia Pathway	R-HSA-6783310	1.157248e-02	1.937
Meiotic recombination	R-HSA-912446	1.086705e-02	1.964
Macroautophagy	R-HSA-1632852	1.073525e-02	1.969
Nervous system development	R-HSA-9675108	1.140560e-02	1.943
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.054735e-02	1.977
Transcriptional Regulation by TP53	R-HSA-3700989	1.141648e-02	1.942
Maturation of protein E	R-HSA-9683683	1.057461e-02	1.976
Maturation of protein E	R-HSA-9694493	1.057461e-02	1.976
Telomere Maintenance	R-HSA-157579	1.190966e-02	1.924
mRNA Splicing - Major Pathway	R-HSA-72163	1.206824e-02	1.918
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.213094e-02	1.916
Amplification of signal from the kinetochores	R-HSA-141424	1.213094e-02	1.916
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.219369e-02	1.914
mRNA 3'-end processing	R-HSA-72187	1.232437e-02	1.909
HIV Life Cycle	R-HSA-162587	1.233893e-02	1.909
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.262769e-02	1.899
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.269800e-02	1.896
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.269800e-02	1.896
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.273417e-02	1.895
Metabolism of non-coding RNA	R-HSA-194441	1.284647e-02	1.891
snRNP Assembly	R-HSA-191859	1.284647e-02	1.891
Termination of translesion DNA synthesis	R-HSA-5656169	1.285731e-02	1.891
DNA methylation	R-HSA-5334118	1.285731e-02	1.891
AURKA Activation by TPX2	R-HSA-8854518	1.317849e-02	1.880
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.320860e-02	1.879
Protein folding	R-HSA-391251	1.322029e-02	1.879
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.335343e-02	1.874
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.335494e-02	1.874
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.340509e-02	1.873
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	1.562167e-02	1.806
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.471141e-02	1.832
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.501566e-02	1.823
mRNA Splicing	R-HSA-72172	1.467300e-02	1.833
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.515480e-02	1.819
Neurodegenerative Diseases	R-HSA-8863678	1.515480e-02	1.819
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.515480e-02	1.819
TCF dependent signaling in response to WNT	R-HSA-201681	1.596628e-02	1.797
Signaling by ERBB2	R-HSA-1227986	1.440372e-02	1.842
Kinesins	R-HSA-983189	1.440372e-02	1.842
Post NMDA receptor activation events	R-HSA-438064	1.467079e-02	1.834
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.606448e-02	1.794
Translesion synthesis by REV1	R-HSA-110312	1.611814e-02	1.793
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.631208e-02	1.787
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.635792e-02	1.786
Centrosome maturation	R-HSA-380287	1.635792e-02	1.786
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.696351e-02	1.770
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.700309e-02	1.769
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.764940e-02	1.753
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.779484e-02	1.750
Interleukin-12 signaling	R-HSA-9020591	1.804246e-02	1.744
MTOR signalling	R-HSA-165159	1.831391e-02	1.737
Depyrimidination	R-HSA-73928	1.831391e-02	1.737
Cleavage of the damaged pyrimidine	R-HSA-110329	1.831391e-02	1.737
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.908304e-02	1.719
Diseases of Telomere Maintenance	R-HSA-9673013	1.908304e-02	1.719
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.908304e-02	1.719
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.908304e-02	1.719
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.908304e-02	1.719
DNA Damage Bypass	R-HSA-73893	1.918444e-02	1.717
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.954827e-02	1.709
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.954827e-02	1.709
Ovarian tumor domain proteases	R-HSA-5689896	1.954827e-02	1.709
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.995441e-02	1.700
Translesion synthesis by POLI	R-HSA-5656121	2.012628e-02	1.696
Negative regulation of FLT3	R-HSA-9706369	2.012628e-02	1.696
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.059602e-02	1.686
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.059602e-02	1.686
Oncogenic MAPK signaling	R-HSA-6802957	2.144233e-02	1.669
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.476213e-02	1.606
Translesion synthesis by POLK	R-HSA-5655862	2.476213e-02	1.606
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.491407e-02	1.604
Dual incision in TC-NER	R-HSA-6782135	2.445276e-02	1.612
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.596636e-02	1.586
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.596636e-02	1.586
L1CAM interactions	R-HSA-373760	2.166057e-02	1.664
Gap junction trafficking	R-HSA-190828	2.350204e-02	1.629
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.426180e-02	1.615
Regulation of necroptotic cell death	R-HSA-5675482	2.379604e-02	1.623
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.203286e-02	1.657
RNA Polymerase I Promoter Opening	R-HSA-73728	2.491407e-02	1.604
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.236158e-02	1.650
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.379604e-02	1.623
Signaling by FGFR3	R-HSA-5654741	2.646434e-02	1.577
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.663846e-02	1.574
Switching of origins to a post-replicative state	R-HSA-69052	2.663846e-02	1.574
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.663846e-02	1.574
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.697793e-02	1.569
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.704498e-02	1.568
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.767353e-02	1.558
Interleukin-12 family signaling	R-HSA-447115	2.777526e-02	1.556
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.799451e-02	1.553
p75NTR recruits signalling complexes	R-HSA-209543	2.799451e-02	1.553
rRNA processing	R-HSA-72312	2.828574e-02	1.548
Interactions of Rev with host cellular proteins	R-HSA-177243	2.884849e-02	1.540
Formation of annular gap junctions	R-HSA-196025	2.968074e-02	1.528
Downregulation of ERBB4 signaling	R-HSA-1253288	2.968074e-02	1.528
Modulation by Mtb of host immune system	R-HSA-9637628	2.968074e-02	1.528
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.968721e-02	1.527
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.002593e-02	1.523
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.002593e-02	1.523
Dual Incision in GG-NER	R-HSA-5696400	3.122919e-02	1.505
Transcriptional regulation by RUNX1	R-HSA-8878171	3.138743e-02	1.503
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.254843e-02	1.487
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	3.254843e-02	1.487
FLT3 Signaling	R-HSA-9607240	3.254843e-02	1.487
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	4.010695e-02	1.397
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	4.010695e-02	1.397
TRAF3 deficiency - HSE	R-HSA-5602571	4.010695e-02	1.397
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	4.010695e-02	1.397
Gap junction degradation	R-HSA-190873	3.880857e-02	1.411
AKT phosphorylates targets in the nucleus	R-HSA-198693	3.880857e-02	1.411
ALK mutants bind TKIs	R-HSA-9700645	3.880857e-02	1.411
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	3.488972e-02	1.457
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.605117e-02	1.443
Late endosomal microautophagy	R-HSA-9615710	3.345163e-02	1.476
Activation of the pre-replicative complex	R-HSA-68962	3.838643e-02	1.416
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.838643e-02	1.416
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.158163e-02	1.381
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.158163e-02	1.381
Ribosome-associated quality control	R-HSA-9948299	4.108977e-02	1.386
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.790957e-02	1.421
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.685227e-02	1.434
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.880857e-02	1.411
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.639574e-02	1.439
Gap junction trafficking and regulation	R-HSA-157858	4.102285e-02	1.387
Breakdown of the nuclear lamina	R-HSA-352238	4.010695e-02	1.397
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.343465e-02	1.476
Cyclin E associated events during G1/S transition	R-HSA-69202	3.899447e-02	1.409
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.677104e-02	1.434
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	4.117186e-02	1.385
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.102285e-02	1.387
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.102285e-02	1.387
Base Excision Repair	R-HSA-73884	3.541068e-02	1.451
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.880857e-02	1.411
Polo-like kinase mediated events	R-HSA-156711	3.605117e-02	1.443
Host Interactions of HIV factors	R-HSA-162909	3.773570e-02	1.423
FLT3 signaling in disease	R-HSA-9682385	4.013980e-02	1.396
Regulation of mitotic cell cycle	R-HSA-453276	4.251306e-02	1.371
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.251306e-02	1.371
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	4.274829e-02	1.369
Regulation of signaling by CBL	R-HSA-912631	4.275770e-02	1.369
Golgi-to-ER retrograde transport	R-HSA-8856688	4.329567e-02	1.364
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.378591e-02	1.359
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.378591e-02	1.359
Regulation of CDH1 Function	R-HSA-9764561	4.470764e-02	1.350
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.518182e-02	1.345
Cleavage of the damaged purine	R-HSA-110331	4.518182e-02	1.345
p75 NTR receptor-mediated signalling	R-HSA-193704	4.569749e-02	1.340
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.643133e-02	1.333
TGFBR3 expression	R-HSA-9839394	4.728706e-02	1.325
HDMs demethylate histones	R-HSA-3214842	4.728706e-02	1.325
Signaling by ROBO receptors	R-HSA-376176	4.760757e-02	1.322
HIV Infection	R-HSA-162906	4.848556e-02	1.314
Influenza Infection	R-HSA-168255	4.856770e-02	1.314
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.936604e-02	1.307
2-LTR circle formation	R-HSA-164843	4.936604e-02	1.307
Folding of actin by CCT/TriC	R-HSA-390450	4.936604e-02	1.307
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.936604e-02	1.307
Pexophagy	R-HSA-9664873	4.936604e-02	1.307
Synthesis of DNA	R-HSA-69239	4.990139e-02	1.302
Glycogen synthesis	R-HSA-3322077	5.019804e-02	1.299
RIPK1-mediated regulated necrosis	R-HSA-5213460	5.062949e-02	1.296
Depurination	R-HSA-73927	5.062949e-02	1.296
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.158852e-02	1.287
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.158852e-02	1.287
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.158852e-02	1.287
p75NTR signals via NF-kB	R-HSA-193639	5.158852e-02	1.287
CDC6 association with the ORC:origin complex	R-HSA-68689	5.293758e-02	1.276
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.293758e-02	1.276
Metalloprotease DUBs	R-HSA-5689901	5.418955e-02	1.266
Late Phase of HIV Life Cycle	R-HSA-162599	5.480457e-02	1.261
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	5.504803e-02	1.259
Orc1 removal from chromatin	R-HSA-68949	5.504803e-02	1.259
IPs transport between nucleus and cytosol	R-HSA-1855170	5.602764e-02	1.252
Transport of the SLBP independent Mature mRNA	R-HSA-159227	5.602764e-02	1.252
Activation of ATR in response to replication stress	R-HSA-176187	5.602764e-02	1.252
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.602764e-02	1.252
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.607527e-02	1.251
Phosphorylation of the APC/C	R-HSA-176412	6.141740e-02	1.212
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	7.223103e-02	1.141
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	7.223103e-02	1.141
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	6.732113e-02	1.172
RNA Polymerase I Transcription Termination	R-HSA-73863	6.168951e-02	1.210
Interaction between L1 and Ankyrins	R-HSA-445095	6.168951e-02	1.210
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	6.288830e-02	1.201
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.183074e-02	1.209
HDACs deacetylate histones	R-HSA-3214815	7.195036e-02	1.143
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.166989e-02	1.145
Nuclear Receptor transcription pathway	R-HSA-383280	7.352715e-02	1.134
Formation of a pool of free 40S subunits	R-HSA-72689	5.899151e-02	1.229
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.642514e-02	1.178
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.166989e-02	1.145
Integration of provirus	R-HSA-162592	7.471282e-02	1.127
Signaling by RAF1 mutants	R-HSA-9656223	7.662821e-02	1.116
Resolution of D-Loop Structures	R-HSA-5693537	6.288830e-02	1.201
Intraflagellar transport	R-HSA-5620924	7.448199e-02	1.128
MAPK6/MAPK4 signaling	R-HSA-5687128	6.991214e-02	1.155
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	6.948651e-02	1.158
G1/S DNA Damage Checkpoints	R-HSA-69615	7.497857e-02	1.125
Regulation of PTEN stability and activity	R-HSA-8948751	6.035531e-02	1.219
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	6.948651e-02	1.158
tRNA processing in the nucleus	R-HSA-6784531	6.920532e-02	1.160
Gap junction assembly	R-HSA-190861	7.025031e-02	1.153
Transcriptional regulation by RUNX3	R-HSA-8878159	6.735129e-02	1.172
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	6.664383e-02	1.176
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.948651e-02	1.158
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	6.598804e-02	1.181
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.223103e-02	1.141
Neurofascin interactions	R-HSA-447043	6.995044e-02	1.155
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	6.134446e-02	1.212
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	6.288830e-02	1.201
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.166989e-02	1.145
Assembly Of The HIV Virion	R-HSA-175474	6.732113e-02	1.172
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.598804e-02	1.181
Nuclear import of Rev protein	R-HSA-180746	7.025031e-02	1.153
NF-kB is activated and signals survival	R-HSA-209560	7.471282e-02	1.127
Regulation of NF-kappa B signaling	R-HSA-9758274	6.141740e-02	1.212
mTORC1-mediated signalling	R-HSA-166208	7.700921e-02	1.113
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.700921e-02	1.113
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.700921e-02	1.113
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.725083e-02	1.112
Oncogene Induced Senescence	R-HSA-2559585	7.811662e-02	1.107
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.824538e-02	1.107
NRAGE signals death through JNK	R-HSA-193648	7.824538e-02	1.107
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.850014e-02	1.105
Interferon Signaling	R-HSA-913531	7.924990e-02	1.101
Ub-specific processing proteases	R-HSA-5689880	8.021097e-02	1.096
Hedgehog 'off' state	R-HSA-5610787	8.133100e-02	1.090
Glycolysis	R-HSA-70171	8.133100e-02	1.090
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.310320e-02	1.080
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.401528e-02	1.076
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.401528e-02	1.076
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	8.401528e-02	1.076
Regulation of FZD by ubiquitination	R-HSA-4641263	8.401528e-02	1.076
Glycogen storage diseases	R-HSA-3229121	8.401528e-02	1.076
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	8.779946e-02	1.057
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.781059e-02	1.056
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	8.909145e-02	1.050
Recycling of eIF2:GDP	R-HSA-72731	8.909145e-02	1.050
IRAK1 recruits IKK complex	R-HSA-937039	8.942069e-02	1.049
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.942069e-02	1.049
VLDLR internalisation and degradation	R-HSA-8866427	8.942069e-02	1.049
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.141780e-02	1.039
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.156564e-02	1.038
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.220917e-02	1.035
Signaling by FGFR4	R-HSA-5654743	9.220917e-02	1.035
Organelle biogenesis and maintenance	R-HSA-1852241	9.337038e-02	1.030
Degradation of DVL	R-HSA-4641258	9.536119e-02	1.021
RNA Polymerase II Pre-transcription Events	R-HSA-674695	9.562762e-02	1.019
Signaling by FGFR in disease	R-HSA-1226099	9.562762e-02	1.019
Hedgehog ligand biogenesis	R-HSA-5358346	9.628571e-02	1.016
Mismatch Repair	R-HSA-5358508	9.674652e-02	1.014
Signaling by ERBB2 ECD mutants	R-HSA-9665348	9.674652e-02	1.014
Depolymerization of the Nuclear Lamina	R-HSA-4419969	9.674652e-02	1.014
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.723051e-02	1.012
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	9.739111e-02	1.011
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	9.739111e-02	1.011
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	9.739111e-02	1.011
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	9.739111e-02	1.011
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.771818e-02	1.010
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.771818e-02	1.010
Drug resistance of KIT mutants	R-HSA-9669937	9.940916e-02	1.003
Defective Base Excision Repair Associated with NEIL1	R-HSA-9616334	9.940916e-02	1.003
KIT mutants bind TKIs	R-HSA-9669921	9.940916e-02	1.003
Imatinib-resistant KIT mutants	R-HSA-9669917	9.940916e-02	1.003
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.940916e-02	1.003
Sunitinib-resistant KIT mutants	R-HSA-9669934	9.940916e-02	1.003
Sorafenib-resistant KIT mutants	R-HSA-9669936	9.940916e-02	1.003
Nilotinib-resistant KIT mutants	R-HSA-9669926	9.940916e-02	1.003
Dasatinib-resistant KIT mutants	R-HSA-9669914	9.940916e-02	1.003
Regorafenib-resistant KIT mutants	R-HSA-9669929	9.940916e-02	1.003
Masitinib-resistant KIT mutants	R-HSA-9669924	9.940916e-02	1.003
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.312505e-01	0.882
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.312505e-01	0.882
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.312505e-01	0.882
Type I hemidesmosome assembly	R-HSA-446107	1.101525e-01	0.958
Interleukin-18 signaling	R-HSA-9012546	1.101525e-01	0.958
Lipophagy	R-HSA-9613354	1.329080e-01	0.876
Formation of axial mesoderm	R-HSA-9796292	1.054011e-01	0.977
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.054011e-01	0.977
Regulation of KIT signaling	R-HSA-1433559	1.225737e-01	0.912
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.103925e-01	0.957
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.103925e-01	0.957
Co-inhibition by CTLA4	R-HSA-389513	1.249132e-01	0.903
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.249132e-01	0.903
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.249132e-01	0.903
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.249132e-01	0.903
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.249132e-01	0.903
Striated Muscle Contraction	R-HSA-390522	1.309158e-01	0.883
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.187966e-01	0.925
Signaling downstream of RAS mutants	R-HSA-9649948	1.187966e-01	0.925
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.187966e-01	0.925
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.470230e-01	0.833
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.470230e-01	0.833
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.161573e-01	0.935
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.273166e-01	0.895
HCMV Early Events	R-HSA-9609690	1.453351e-01	0.838
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.430878e-01	0.844
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.192849e-01	0.923
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.249132e-01	0.903
Asymmetric localization of PCP proteins	R-HSA-4608870	1.095108e-01	0.961
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.192849e-01	0.923
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.470230e-01	0.833
Diseases of mitotic cell cycle	R-HSA-9675126	1.082138e-01	0.966
Peptide chain elongation	R-HSA-156902	1.465171e-01	0.834
Regulation of TNFR1 signaling	R-HSA-5357905	1.187966e-01	0.925
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.095108e-01	0.961
Signaling by RAS mutants	R-HSA-6802949	1.187966e-01	0.925
Degradation of CRY and PER proteins	R-HSA-9932298	1.470230e-01	0.833
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.312505e-01	0.882
MASTL Facilitates Mitotic Progression	R-HSA-2465910	1.329080e-01	0.876
PTEN Regulation	R-HSA-6807070	1.031033e-01	0.987
TNF signaling	R-HSA-75893	1.400869e-01	0.854
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.085783e-01	0.964
Activation of HOX genes during differentiation	R-HSA-5619507	1.085783e-01	0.964
Hh mutants are degraded by ERAD	R-HSA-5362768	1.357530e-01	0.867
Intracellular signaling by second messengers	R-HSA-9006925	1.398906e-01	0.854
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.357530e-01	0.867
Cyclin D associated events in G1	R-HSA-69231	1.006465e-01	0.997
G1 Phase	R-HSA-69236	1.006465e-01	0.997
Sema4D in semaphorin signaling	R-HSA-400685	1.104895e-01	0.957
Co-inhibition by PD-1	R-HSA-389948	1.226860e-01	0.911
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.083530e-01	0.965
G alpha (12/13) signalling events	R-HSA-416482	1.239538e-01	0.907
COPI-mediated anterograde transport	R-HSA-6807878	1.031096e-01	0.987
Signaling by FGFR1 in disease	R-HSA-5655302	1.470230e-01	0.833
Mitophagy	R-HSA-5205647	1.430878e-01	0.844
Regulation of T cell activation by CD28 family	R-HSA-388841	1.469295e-01	0.833
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.312505e-01	0.882
E2F mediated regulation of DNA replication	R-HSA-113510	1.103925e-01	0.957
Protein hydroxylation	R-HSA-9629569	1.249132e-01	0.903
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.357530e-01	0.867
Regulated Necrosis	R-HSA-5218859	1.083530e-01	0.965
Signaling by Hedgehog	R-HSA-5358351	1.439028e-01	0.842
Death Receptor Signaling	R-HSA-73887	1.441870e-01	0.841
RNA Polymerase II Transcription	R-HSA-73857	1.051664e-01	0.978
Regulation of CDH11 gene transcription	R-HSA-9762293	1.329080e-01	0.876
NRIF signals cell death from the nucleus	R-HSA-205043	1.225737e-01	0.912
Diseases of DNA repair	R-HSA-9675135	1.187966e-01	0.925
Negative regulation of MAPK pathway	R-HSA-5675221	1.470230e-01	0.833
Vpu mediated degradation of CD4	R-HSA-180534	1.309158e-01	0.883
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	1.430878e-01	0.844
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.430878e-01	0.844
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.187966e-01	0.925
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.364124e-01	0.865
Cellular response to mitochondrial stress	R-HSA-9840373	1.329080e-01	0.876
Early Phase of HIV Life Cycle	R-HSA-162594	1.402619e-01	0.853
Stabilization of p53	R-HSA-69541	1.145951e-01	0.941
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.430878e-01	0.844
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.214704e-01	0.916
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.101525e-01	0.958
SARS-CoV-2-host interactions	R-HSA-9705683	1.377941e-01	0.861
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.225737e-01	0.912
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.357530e-01	0.867
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.230652e-01	0.910
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.230652e-01	0.910
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.230427e-01	0.910
MITF-M-dependent gene expression	R-HSA-9856651	1.218321e-01	0.914
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.408472e-01	0.851
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.145951e-01	0.941
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.402619e-01	0.853
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.192849e-01	0.923
Translation of Structural Proteins	R-HSA-9683701	1.470230e-01	0.833
Degradation of CDH1	R-HSA-9766229	1.491032e-01	0.827
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.501885e-01	0.823
Eukaryotic Translation Termination	R-HSA-72764	1.524869e-01	0.817
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.557795e-01	0.807
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.557795e-01	0.807
Regulation of Apoptosis	R-HSA-169911	1.557795e-01	0.807
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.563864e-01	0.806
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.563864e-01	0.806
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.571236e-01	0.804
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.577629e-01	0.802
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.587335e-01	0.799
Regulation of RAS by GAPs	R-HSA-5658442	1.599871e-01	0.796
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.601221e-01	0.796
Regulation of BACH1 activity	R-HSA-9708530	1.601221e-01	0.796
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.646715e-01	0.783
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.646715e-01	0.783
PIP3 activates AKT signaling	R-HSA-1257604	1.652164e-01	0.782
IRS activation	R-HSA-74713	1.673002e-01	0.777
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	1.673002e-01	0.777
Nectin/Necl trans heterodimerization	R-HSA-420597	1.673002e-01	0.777
Pyrophosphate hydrolysis	R-HSA-71737	1.673002e-01	0.777
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.673002e-01	0.777
Vesicle-mediated transport	R-HSA-5653656	1.683251e-01	0.774
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.689671e-01	0.772
RNA Polymerase III Transcription	R-HSA-74158	1.689671e-01	0.772
Vif-mediated degradation of APOBEC3G	R-HSA-180585	1.689671e-01	0.772
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.889414e-01	0.724
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.889414e-01	0.724
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.889414e-01	0.724
Hereditary fructose intolerance	R-HSA-5657560	1.889414e-01	0.724
UNC93B1 deficiency - HSE	R-HSA-5602415	1.889414e-01	0.724
TICAM1 deficiency - HSE	R-HSA-5602566	1.889414e-01	0.724
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.889414e-01	0.724
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	1.889414e-01	0.724
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.889414e-01	0.724
t(4;14) translocations of FGFR3	R-HSA-2033515	2.695776e-01	0.569
Signaling by FGFR3 fusions in cancer	R-HSA-8853334	2.695776e-01	0.569
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	2.695776e-01	0.569
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	2.695776e-01	0.569
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.695776e-01	0.569
Signaling by TCF7L2 mutants	R-HSA-5339700	2.695776e-01	0.569
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	R-HSA-5619045	2.695776e-01	0.569
Defective VWF binding to collagen type I	R-HSA-9845622	2.695776e-01	0.569
Defective HK1 causes hexokinase deficiency (HK deficiency)	R-HSA-5619056	2.695776e-01	0.569
Defective SLC34A2 causes PALM	R-HSA-5687583	2.695776e-01	0.569
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.695776e-01	0.569
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.695776e-01	0.569
Signaling by kinase domain mutants of KIT	R-HSA-9669933	2.695776e-01	0.569
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	2.047707e-01	0.689
Defective ALG9 causes CDG-1l	R-HSA-4720454	3.422011e-01	0.466
Signalling to ERK5	R-HSA-198765	3.422011e-01	0.466
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.422011e-01	0.466
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.422011e-01	0.466
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.422011e-01	0.466
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.422011e-01	0.466
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.422011e-01	0.466
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.422011e-01	0.466
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.430239e-01	0.614
Autointegration results in viral DNA circles	R-HSA-177539	2.430239e-01	0.614
G2/M DNA replication checkpoint	R-HSA-69478	2.430239e-01	0.614
PECAM1 interactions	R-HSA-210990	1.825642e-01	0.739
Signaling by APC mutants	R-HSA-4839744	1.825642e-01	0.739
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.825642e-01	0.739
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.825642e-01	0.739
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.825642e-01	0.739
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.089992e-01	0.680
ERKs are inactivated	R-HSA-202670	2.089992e-01	0.680
Signaling by GSK3beta mutants	R-HSA-5339716	2.089992e-01	0.680
RUNX3 regulates WNT signaling	R-HSA-8951430	2.815342e-01	0.550
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.815342e-01	0.550
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	2.815342e-01	0.550
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	2.815342e-01	0.550
Repression of WNT target genes	R-HSA-4641265	2.362066e-01	0.627
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.362066e-01	0.627
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.362066e-01	0.627
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.362066e-01	0.627
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.362066e-01	0.627
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.362066e-01	0.627
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	1.732293e-01	0.761
FGFR3 mutant receptor activation	R-HSA-2033514	2.639761e-01	0.578
Signaling by activated point mutants of FGFR3	R-HSA-1839130	2.639761e-01	0.578
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	2.639761e-01	0.578
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	2.228879e-01	0.652
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	2.921112e-01	0.534
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	2.274464e-01	0.643
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.826242e-01	0.738
Processive synthesis on the lagging strand	R-HSA-69183	3.204308e-01	0.494
Beta-catenin phosphorylation cascade	R-HSA-196299	3.204308e-01	0.494
Lagging Strand Synthesis	R-HSA-69186	2.907641e-01	0.536
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.907641e-01	0.536
Signaling by FGFR3 in disease	R-HSA-5655332	2.660066e-01	0.575
Processive synthesis on the C-strand of the telomere	R-HSA-174414	2.660066e-01	0.575
EPHA-mediated growth cone collapse	R-HSA-3928663	2.660066e-01	0.575
Formation of RNA Pol II elongation complex	R-HSA-112382	1.828496e-01	0.738
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.447413e-01	0.611
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	2.261238e-01	0.646
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	3.140264e-01	0.503
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.140264e-01	0.503
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	3.140264e-01	0.503
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.947977e-01	0.710
RAF activation	R-HSA-5673000	2.619816e-01	0.582
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	2.619816e-01	0.582
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	2.569153e-01	0.590
HIV Transcription Initiation	R-HSA-167161	2.569153e-01	0.590
RNA Polymerase II Transcription Initiation	R-HSA-75953	2.569153e-01	0.590
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	3.058733e-01	0.514
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.727486e-01	0.564
RNA Polymerase II Promoter Escape	R-HSA-73776	2.888280e-01	0.539
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.028384e-01	0.693
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	3.215859e-01	0.493
Viral mRNA Translation	R-HSA-192823	3.113191e-01	0.507
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.029137e-01	0.519
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.029137e-01	0.519
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.029137e-01	0.519
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.963234e-01	0.707
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.963234e-01	0.707
Extension of Telomeres	R-HSA-180786	2.725933e-01	0.564
ERK/MAPK targets	R-HSA-198753	2.907641e-01	0.536
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.261319e-01	0.487
MAP2K and MAPK activation	R-HSA-5674135	2.569153e-01	0.590
Ephrin signaling	R-HSA-3928664	2.228879e-01	0.652
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.465297e-01	0.608
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	3.374405e-01	0.472
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.465297e-01	0.608
Signaling by CSF3 (G-CSF)	R-HSA-9674555	3.058733e-01	0.514
Abacavir transmembrane transport	R-HSA-2161517	2.430239e-01	0.614
PTK6 Expression	R-HSA-8849473	2.815342e-01	0.550
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	2.012520e-01	0.696
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.012520e-01	0.696
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.198727e-01	0.495
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.261319e-01	0.487
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.805640e-01	0.552
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.102426e-01	0.508
EPH-Ephrin signaling	R-HSA-2682334	2.763516e-01	0.559
MyD88-independent TLR4 cascade	R-HSA-166166	2.159921e-01	0.666
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.734692e-01	0.761
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.159921e-01	0.666
Signaling by WNT	R-HSA-195721	2.268802e-01	0.644
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.047707e-01	0.689
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.825642e-01	0.739
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	2.232212e-01	0.651
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.372677e-01	0.625
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.261319e-01	0.487
Signaling by FGFR2	R-HSA-5654738	3.193684e-01	0.496
Adrenoceptors	R-HSA-390696	3.198727e-01	0.495
Signaling by NODAL	R-HSA-1181150	2.677514e-01	0.572
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.430239e-01	0.614
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.834037e-01	0.737
FGFR1 mutant receptor activation	R-HSA-1839124	2.278494e-01	0.642
Platelet sensitization by LDL	R-HSA-432142	2.228879e-01	0.652
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.619816e-01	0.582
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.058733e-01	0.514
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.307959e-01	0.480
Formation of editosomes by ADAR proteins	R-HSA-77042	1.889414e-01	0.724
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.695776e-01	0.569
Transport of connexins along the secretory pathway	R-HSA-190827	2.695776e-01	0.569
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.047707e-01	0.689
mRNA Editing: A to I Conversion	R-HSA-75064	3.422011e-01	0.466
C6 deamination of adenosine	R-HSA-75102	3.422011e-01	0.466
Regulation of cortical dendrite branching	R-HSA-8985801	3.422011e-01	0.466
Influenza Virus Induced Apoptosis	R-HSA-168277	3.422011e-01	0.466
CREB phosphorylation	R-HSA-199920	2.430239e-01	0.614
Signaling by AXIN mutants	R-HSA-4839735	2.089992e-01	0.680
Signaling by AMER1 mutants	R-HSA-4839748	2.089992e-01	0.680
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.362066e-01	0.627
Degradation of AXIN	R-HSA-4641257	1.826242e-01	0.738
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.826242e-01	0.738
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.204308e-01	0.494
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.963234e-01	0.707
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.963234e-01	0.707
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.140264e-01	0.503
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.619816e-01	0.582
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.619816e-01	0.582
Viral Messenger RNA Synthesis	R-HSA-168325	1.925542e-01	0.715
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	2.850111e-01	0.545
Signaling by FGFR1	R-HSA-5654736	2.325022e-01	0.634
MAP kinase activation	R-HSA-450294	1.925542e-01	0.715
Regulation of PTEN gene transcription	R-HSA-8943724	2.863914e-01	0.543
ER to Golgi Anterograde Transport	R-HSA-199977	2.130198e-01	0.672
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.888280e-01	0.539
Signaling by MET	R-HSA-6806834	2.177045e-01	0.662
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.362066e-01	0.627
Eukaryotic Translation Elongation	R-HSA-156842	1.892921e-01	0.723
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	2.112332e-01	0.675
Interleukin-17 signaling	R-HSA-448424	3.040035e-01	0.517
Glycogen metabolism	R-HSA-8982491	2.261238e-01	0.646
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	2.047707e-01	0.689
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.815342e-01	0.550
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.907298e-01	0.720
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.334986e-01	0.477
Regulation of RUNX2 expression and activity	R-HSA-8939902	3.003710e-01	0.522
Oligomerization of connexins into connexons	R-HSA-190704	2.695776e-01	0.569
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.047707e-01	0.689
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.430239e-01	0.614
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	2.362066e-01	0.627
Evasion by RSV of host interferon responses	R-HSA-9833109	1.952943e-01	0.709
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.677514e-01	0.572
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.907641e-01	0.536
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.660066e-01	0.575
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.261238e-01	0.646
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.261238e-01	0.646
Hedgehog 'on' state	R-HSA-5632684	3.173372e-01	0.498
Signaling by TGFBR3	R-HSA-9839373	3.381954e-01	0.471
Signaling by Hippo	R-HSA-2028269	2.012520e-01	0.696
Basigin interactions	R-HSA-210991	2.907641e-01	0.536
ABC-family proteins mediated transport	R-HSA-382556	2.787608e-01	0.555
Reproduction	R-HSA-1474165	2.003924e-01	0.698
Semaphorin interactions	R-HSA-373755	2.156727e-01	0.666
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.430239e-01	0.614
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.795240e-01	0.554
Interleukin-37 signaling	R-HSA-9008059	3.261319e-01	0.487
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.777840e-01	0.556
Selenocysteine synthesis	R-HSA-2408557	2.894926e-01	0.538
Regulation of pyruvate metabolism	R-HSA-9861718	3.381954e-01	0.471
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.221224e-01	0.492
MITF-M-regulated melanocyte development	R-HSA-9730414	1.982933e-01	0.703
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.422011e-01	0.466
ChREBP activates metabolic gene expression	R-HSA-163765	1.825642e-01	0.739
Nephrin family interactions	R-HSA-373753	2.677514e-01	0.572
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.793884e-01	0.746
MHC class II antigen presentation	R-HSA-2132295	2.739141e-01	0.562
SARS-CoV-1-host interactions	R-HSA-9692914	2.603951e-01	0.584
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.051186e-01	0.516
RMTs methylate histone arginines	R-HSA-3214858	3.051186e-01	0.516
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	3.287872e-01	0.483
Signaling by PTK6	R-HSA-8848021	3.287872e-01	0.483
Glucose metabolism	R-HSA-70326	2.192297e-01	0.659
Maturation of nucleoprotein	R-HSA-9683610	2.639761e-01	0.578
Transcriptional regulation by RUNX2	R-HSA-8878166	2.369071e-01	0.625
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.963234e-01	0.707
G1/S-Specific Transcription	R-HSA-69205	2.973217e-01	0.527
STING mediated induction of host immune responses	R-HSA-1834941	2.450906e-01	0.611
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.815342e-01	0.550
Uptake and function of diphtheria toxin	R-HSA-5336415	2.815342e-01	0.550
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.802933e-01	0.744
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.198727e-01	0.495
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	3.140264e-01	0.503
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.907641e-01	0.536
Amyloid fiber formation	R-HSA-977225	2.284445e-01	0.641
Signaling by NOTCH3	R-HSA-9012852	3.412361e-01	0.467
XBP1(S) activates chaperone genes	R-HSA-381038	2.028384e-01	0.693
SARS-CoV-1 Infection	R-HSA-9678108	3.029288e-01	0.519
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.907641e-01	0.536
IRE1alpha activates chaperones	R-HSA-381070	2.653302e-01	0.576
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.325022e-01	0.634
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.228879e-01	0.652
Signaling by Nuclear Receptors	R-HSA-9006931	3.427197e-01	0.465
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.451362e-01	0.462
Budding and maturation of HIV virion	R-HSA-162588	3.465226e-01	0.460
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.487694e-01	0.457
Plasma lipoprotein clearance	R-HSA-8964043	3.517872e-01	0.454
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.549132e-01	0.450
Signaling by FGFR	R-HSA-190236	3.569363e-01	0.447
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.575542e-01	0.447
Transcriptional Regulation by MECP2	R-HSA-8986944	3.575542e-01	0.447
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.576932e-01	0.446
WNT mediated activation of DVL	R-HSA-201688	3.576932e-01	0.446
GP1b-IX-V activation signalling	R-HSA-430116	3.576932e-01	0.446
Calcineurin activates NFAT	R-HSA-2025928	3.576932e-01	0.446
Regulation of NPAS4 gene transcription	R-HSA-9768777	3.576932e-01	0.446
Interleukin-1 processing	R-HSA-448706	3.576932e-01	0.446
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.576932e-01	0.446
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.576932e-01	0.446
Respiratory syncytial virus genome replication	R-HSA-9834752	3.576932e-01	0.446
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.576932e-01	0.446
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	3.579401e-01	0.446
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.609139e-01	0.443
Growth hormone receptor signaling	R-HSA-982772	3.609139e-01	0.443
DNA strand elongation	R-HSA-69190	3.669846e-01	0.435
Unfolded Protein Response (UPR)	R-HSA-381119	3.717637e-01	0.430
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.722824e-01	0.429
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.769780e-01	0.424
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.769780e-01	0.424
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	3.769780e-01	0.424
Deadenylation of mRNA	R-HSA-429947	3.843599e-01	0.415
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.843599e-01	0.415
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.874596e-01	0.412
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	3.885411e-01	0.411
Transcriptional Regulation by VENTX	R-HSA-8853884	3.885461e-01	0.411
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.947198e-01	0.404
Apoptosis induced DNA fragmentation	R-HSA-140342	3.947198e-01	0.404
Signal attenuation	R-HSA-74749	3.947198e-01	0.404
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	3.947198e-01	0.404
Formation of intermediate mesoderm	R-HSA-9761174	3.947198e-01	0.404
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.947198e-01	0.404
HCMV Infection	R-HSA-9609646	3.965620e-01	0.402
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	3.971295e-01	0.401
Rab regulation of trafficking	R-HSA-9007101	3.993500e-01	0.399
Deadenylation-dependent mRNA decay	R-HSA-429914	4.035206e-01	0.394
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.049233e-01	0.393
Regulation of NPAS4 gene expression	R-HSA-9768759	4.049233e-01	0.393
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	4.069331e-01	0.390
PLC-gamma1 signalling	R-HSA-167021	4.076077e-01	0.390
Activated NTRK3 signals through PLCG1	R-HSA-9034793	4.076077e-01	0.390
MET activates PTPN11	R-HSA-8865999	4.076077e-01	0.390
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	4.076077e-01	0.390
Defective ABCA3 causes SMDP3	R-HSA-5683678	4.076077e-01	0.390
Defective ABCA3 causes SMDP3	R-HSA-5688399	4.076077e-01	0.390
Defective gamma-carboxylation of F9	R-HSA-9673240	4.076077e-01	0.390
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	4.076077e-01	0.390
Type II Na+/Pi cotransporters	R-HSA-427589	4.076077e-01	0.390
CASP5-mediated substrate cleavage	R-HSA-9960525	4.076077e-01	0.390
Histamine receptors	R-HSA-390650	4.076077e-01	0.390
CASP4-mediated substrate cleavage	R-HSA-9960519	4.076077e-01	0.390
Long-term potentiation	R-HSA-9620244	4.076976e-01	0.390
PI3K/AKT Signaling in Cancer	R-HSA-2219528	4.104698e-01	0.387
PCP/CE pathway	R-HSA-4086400	4.131575e-01	0.384
Activation of NF-kappaB in B cells	R-HSA-1169091	4.222126e-01	0.374
Cytokine Signaling in Immune system	R-HSA-1280215	4.236117e-01	0.373
Ca-dependent events	R-HSA-111996	4.252724e-01	0.371
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.252724e-01	0.371
Sensory processing of sound	R-HSA-9659379	4.269867e-01	0.370
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	4.282305e-01	0.368
Calnexin/calreticulin cycle	R-HSA-901042	4.282305e-01	0.368
NOD1/2 Signaling Pathway	R-HSA-168638	4.282305e-01	0.368
Signaling by NOTCH2	R-HSA-1980145	4.282305e-01	0.368
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.307368e-01	0.366
Formation of the posterior neural plate	R-HSA-9832991	4.307368e-01	0.366
Bicarbonate transporters	R-HSA-425381	4.307368e-01	0.366
Suppression of apoptosis	R-HSA-9635465	4.307368e-01	0.366
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.307368e-01	0.366
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.307614e-01	0.366
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.308525e-01	0.366
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.308525e-01	0.366
Suppression of phagosomal maturation	R-HSA-9637687	4.308525e-01	0.366
Apoptotic factor-mediated response	R-HSA-111471	4.324881e-01	0.364
SARS-CoV-2 Infection	R-HSA-9694516	4.340022e-01	0.363
Generic Transcription Pathway	R-HSA-212436	4.368977e-01	0.360
Neurexins and neuroligins	R-HSA-6794361	4.389887e-01	0.358
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.389887e-01	0.358
TBC/RABGAPs	R-HSA-8854214	4.435267e-01	0.353
Response of Mtb to phagocytosis	R-HSA-9637690	4.435267e-01	0.353
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	4.484251e-01	0.348
Cristae formation	R-HSA-8949613	4.537566e-01	0.343
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.537566e-01	0.343
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.537566e-01	0.343
ER Quality Control Compartment (ERQC)	R-HSA-901032	4.537566e-01	0.343
Smooth Muscle Contraction	R-HSA-445355	4.556871e-01	0.341
PI-3K cascade:FGFR3	R-HSA-5654710	4.595700e-01	0.338
Germ layer formation at gastrulation	R-HSA-9754189	4.595700e-01	0.338
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	4.595700e-01	0.338
The NLRP3 inflammasome	R-HSA-844456	4.595700e-01	0.338
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	4.595700e-01	0.338
O2/CO2 exchange in erythrocytes	R-HSA-1480926	4.595700e-01	0.338
Maturation of nucleoprotein	R-HSA-9694631	4.595700e-01	0.338
EPHB-mediated forward signaling	R-HSA-3928662	4.616607e-01	0.336
Neutrophil degranulation	R-HSA-6798695	4.651706e-01	0.332
Activation of RAC1	R-HSA-428540	4.655788e-01	0.332
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.655788e-01	0.332
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.655788e-01	0.332
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.655788e-01	0.332
Signaling by NOTCH	R-HSA-157118	4.662007e-01	0.331
Regulation of gap junction activity	R-HSA-191650	4.665143e-01	0.331
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.665143e-01	0.331
Activated NTRK2 signals through PLCG1	R-HSA-9026527	4.665143e-01	0.331
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.665143e-01	0.331
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.665143e-01	0.331
RET signaling	R-HSA-8853659	4.684304e-01	0.329
Calmodulin induced events	R-HSA-111933	4.684304e-01	0.329
CaM pathway	R-HSA-111997	4.684304e-01	0.329
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.700072e-01	0.328
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.700072e-01	0.328
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.700072e-01	0.328
Telomere Extension By Telomerase	R-HSA-171319	4.763482e-01	0.322
Phase 0 - rapid depolarisation	R-HSA-5576892	4.763482e-01	0.322
Cellular response to starvation	R-HSA-9711097	4.779077e-01	0.321
Platelet Aggregation (Plug Formation)	R-HSA-76009	4.796411e-01	0.319
DAG and IP3 signaling	R-HSA-1489509	4.796411e-01	0.319
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	4.811657e-01	0.318
Circadian clock	R-HSA-9909396	4.827889e-01	0.316
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	4.860809e-01	0.313
Formation of definitive endoderm	R-HSA-9823730	4.860809e-01	0.313
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.860809e-01	0.313
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.885124e-01	0.311
Cellular response to hypoxia	R-HSA-1234174	4.964371e-01	0.304
Signaling by TGFB family members	R-HSA-9006936	4.974639e-01	0.303
Downstream signaling of activated FGFR3	R-HSA-5654708	4.985718e-01	0.302
DARPP-32 events	R-HSA-180024	4.985718e-01	0.302
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.985718e-01	0.302
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.991236e-01	0.302
Polymerase switching	R-HSA-69091	4.991236e-01	0.302
Leading Strand Synthesis	R-HSA-69109	4.991236e-01	0.302
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.991236e-01	0.302
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.991236e-01	0.302
Trafficking and processing of endosomal TLR	R-HSA-1679131	4.991236e-01	0.302
Regulation of IFNG signaling	R-HSA-877312	4.991236e-01	0.302
Diseases associated with surfactant metabolism	R-HSA-5687613	4.991236e-01	0.302
MyD88 dependent cascade initiated on endosome	R-HSA-975155	5.003497e-01	0.301
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.050522e-01	0.297
SLC-mediated transport of inorganic anions	R-HSA-9958790	5.077080e-01	0.294
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	5.150188e-01	0.288
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.195664e-01	0.284
NrCAM interactions	R-HSA-447038	5.195664e-01	0.284
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.195664e-01	0.284
NOSIP mediated eNOS trafficking	R-HSA-203754	5.195664e-01	0.284
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	5.195664e-01	0.284
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.195664e-01	0.284
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	R-HSA-5619067	5.195664e-01	0.284
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.195664e-01	0.284
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.195664e-01	0.284
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.195664e-01	0.284
PTK6 Down-Regulation	R-HSA-8849472	5.195664e-01	0.284
Activation of AKT2	R-HSA-165158	5.195664e-01	0.284
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.195664e-01	0.284
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	5.195664e-01	0.284
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.195664e-01	0.284
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.195664e-01	0.284
Reelin signalling pathway	R-HSA-8866376	5.195664e-01	0.284
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.195664e-01	0.284
Inositol transporters	R-HSA-429593	5.195664e-01	0.284
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.195664e-01	0.284
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.195664e-01	0.284
Assembly of Viral Components at the Budding Site	R-HSA-168316	5.195664e-01	0.284
Activation of BH3-only proteins	R-HSA-114452	5.203781e-01	0.284
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	5.269063e-01	0.278
Platelet Adhesion to exposed collagen	R-HSA-75892	5.312846e-01	0.275
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.312846e-01	0.275
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	5.312846e-01	0.275
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	5.312846e-01	0.275
Translation of Structural Proteins	R-HSA-9694635	5.313623e-01	0.275
NGF-stimulated transcription	R-HSA-9031628	5.323604e-01	0.274
Co-stimulation by CD28	R-HSA-389356	5.323604e-01	0.274
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.323604e-01	0.274
Mitochondrial calcium ion transport	R-HSA-8949215	5.371043e-01	0.270
Signaling by PDGFR in disease	R-HSA-9671555	5.371043e-01	0.270
Transcription of the HIV genome	R-HSA-167172	5.413774e-01	0.266
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	5.417242e-01	0.266
ABC transporter disorders	R-HSA-5619084	5.452661e-01	0.263
Diseases of Immune System	R-HSA-5260271	5.457674e-01	0.263
Diseases associated with the TLR signaling cascade	R-HSA-5602358	5.457674e-01	0.263
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	5.460359e-01	0.263
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.469582e-01	0.262
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.469582e-01	0.262
Pyruvate metabolism	R-HSA-70268	5.488624e-01	0.261
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	5.494369e-01	0.260
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.502523e-01	0.259
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.560088e-01	0.255
Cellular responses to mechanical stimuli	R-HSA-9855142	5.583816e-01	0.253
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.615042e-01	0.251
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.615042e-01	0.251
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.620054e-01	0.250
Removal of the Flap Intermediate	R-HSA-69166	5.620054e-01	0.250
Signaling by FGFR4 in disease	R-HSA-5655291	5.620054e-01	0.250
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.620054e-01	0.250
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.620054e-01	0.250
Signaling by WNT in cancer	R-HSA-4791275	5.625723e-01	0.250
G0 and Early G1	R-HSA-1538133	5.625723e-01	0.250
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.673456e-01	0.246
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.673456e-01	0.246
Noncanonical activation of NOTCH3	R-HSA-9017802	5.673456e-01	0.246
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.673456e-01	0.246
IkBA variant leads to EDA-ID	R-HSA-5603029	5.673456e-01	0.246
Pentose phosphate pathway disease	R-HSA-6791465	5.673456e-01	0.246
Phosphorylation of Emi1	R-HSA-176417	5.673456e-01	0.246
PDE3B signalling	R-HSA-165160	5.673456e-01	0.246
PKB-mediated events	R-HSA-109703	5.673456e-01	0.246
Synthesis of PS	R-HSA-1483101	5.673456e-01	0.246
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.673456e-01	0.246
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.673456e-01	0.246
Signalling to p38 via RIT and RIN	R-HSA-187706	5.673456e-01	0.246
Diseases of Base Excision Repair	R-HSA-9605308	5.673456e-01	0.246
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.673456e-01	0.246
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.673456e-01	0.246
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.673456e-01	0.246
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.673456e-01	0.246
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.673456e-01	0.246
Release of Hh-Np from the secreting cell	R-HSA-5362798	5.673456e-01	0.246
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.673456e-01	0.246
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.683098e-01	0.245
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.683098e-01	0.245
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.683098e-01	0.245
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.683098e-01	0.245
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.683098e-01	0.245
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.691022e-01	0.245
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.808979e-01	0.236
Integrin signaling	R-HSA-354192	5.828908e-01	0.234
Regulation of MECP2 expression and activity	R-HSA-9022692	5.828908e-01	0.234
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.828908e-01	0.234
IRS-related events triggered by IGF1R	R-HSA-2428928	5.835357e-01	0.234
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.851063e-01	0.233
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.851063e-01	0.233
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.851063e-01	0.233
Syndecan interactions	R-HSA-3000170	5.851063e-01	0.233
RNA Polymerase III Chain Elongation	R-HSA-73780	5.912542e-01	0.228
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.912542e-01	0.228
FGFR3 ligand binding and activation	R-HSA-190239	5.912542e-01	0.228
DCC mediated attractive signaling	R-HSA-418885	5.912542e-01	0.228
Signaling by Activin	R-HSA-1502540	5.912542e-01	0.228
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.912542e-01	0.228
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.912542e-01	0.228
Biotin transport and metabolism	R-HSA-196780	5.912542e-01	0.228
Protein methylation	R-HSA-8876725	5.912542e-01	0.228
Formation of the anterior neural plate	R-HSA-9823739	5.912542e-01	0.228
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.912542e-01	0.228
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	5.912542e-01	0.228
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.912542e-01	0.228
Heme signaling	R-HSA-9707616	5.984935e-01	0.223
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.986457e-01	0.223
FOXO-mediated transcription	R-HSA-9614085	6.007867e-01	0.221
Interleukin-1 family signaling	R-HSA-446652	6.078662e-01	0.216
TRAF6 mediated NF-kB activation	R-HSA-933542	6.078803e-01	0.216
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.078803e-01	0.216
Cellular response to chemical stress	R-HSA-9711123	6.090192e-01	0.215
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.103757e-01	0.214
Erythropoietin activates STAT5	R-HSA-9027283	6.103757e-01	0.214
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.103757e-01	0.214
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	6.103757e-01	0.214
HDL clearance	R-HSA-8964011	6.103757e-01	0.214
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.131699e-01	0.212
Signaling by SCF-KIT	R-HSA-1433557	6.173186e-01	0.209
Class I peroxisomal membrane protein import	R-HSA-9603798	6.190202e-01	0.208
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.190202e-01	0.208
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.190202e-01	0.208
Killing mechanisms	R-HSA-9664420	6.190202e-01	0.208
Attachment and Entry	R-HSA-9678110	6.190202e-01	0.208
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.190202e-01	0.208
Activation of SMO	R-HSA-5635838	6.190202e-01	0.208
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.190202e-01	0.208
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.190202e-01	0.208
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.216017e-01	0.206
TCR signaling	R-HSA-202403	6.241674e-01	0.205
Late SARS-CoV-2 Infection Events	R-HSA-9772573	6.243323e-01	0.205
Platelet degranulation	R-HSA-114608	6.248129e-01	0.204
Signaling by NOTCH4	R-HSA-9013694	6.258974e-01	0.203
IGF1R signaling cascade	R-HSA-2428924	6.275525e-01	0.202
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.298045e-01	0.201
Tight junction interactions	R-HSA-420029	6.298045e-01	0.201
Acyl chain remodelling of PS	R-HSA-1482801	6.298045e-01	0.201
Hyaluronan degradation	R-HSA-2160916	6.298045e-01	0.201
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	6.298045e-01	0.201
Surfactant metabolism	R-HSA-5683826	6.341307e-01	0.198
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.349386e-01	0.197
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.349386e-01	0.197
Beta-catenin independent WNT signaling	R-HSA-3858494	6.351564e-01	0.197
Protein-protein interactions at synapses	R-HSA-6794362	6.374212e-01	0.196
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.389204e-01	0.195
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.416306e-01	0.193
Translation	R-HSA-72766	6.429964e-01	0.192
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.453087e-01	0.190
Heme assimilation	R-HSA-9927020	6.453087e-01	0.190
Passive transport by Aquaporins	R-HSA-432047	6.453087e-01	0.190
tRNA modification in the mitochondrion	R-HSA-6787450	6.453087e-01	0.190
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.453087e-01	0.190
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.453087e-01	0.190
Inositol phosphate metabolism	R-HSA-1483249	6.458801e-01	0.190
MET activates PI3K/AKT signaling	R-HSA-8851907	6.491285e-01	0.188
TRIF-mediated programmed cell death	R-HSA-2562578	6.491285e-01	0.188
SOS-mediated signalling	R-HSA-112412	6.491285e-01	0.188
FGFR3b ligand binding and activation	R-HSA-190371	6.491285e-01	0.188
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.491285e-01	0.188
Reuptake of GABA	R-HSA-888593	6.491285e-01	0.188
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.491285e-01	0.188
Synthesis of PIPs in the nucleus	R-HSA-8847453	6.491285e-01	0.188
Ca2+ activated K+ channels	R-HSA-1296052	6.491285e-01	0.188
Cation-coupled Chloride cotransporters	R-HSA-426117	6.491285e-01	0.188
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.491285e-01	0.188
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.491285e-01	0.188
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	6.508653e-01	0.187
TRP channels	R-HSA-3295583	6.508653e-01	0.187
Urea cycle	R-HSA-70635	6.508653e-01	0.187
Signaling by NOTCH1	R-HSA-1980143	6.521143e-01	0.186
Response of endothelial cells to shear stress	R-HSA-9860931	6.577758e-01	0.182
Signal Transduction	R-HSA-162582	6.602770e-01	0.180
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.655874e-01	0.177
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.655874e-01	0.177
mRNA Splicing - Minor Pathway	R-HSA-72165	6.663617e-01	0.176
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.701391e-01	0.174
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	6.710557e-01	0.173
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	6.710557e-01	0.173
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.710557e-01	0.173
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	6.710557e-01	0.173
TRAF6 mediated IRF7 activation	R-HSA-933541	6.757660e-01	0.170
MAPK family signaling cascades	R-HSA-5683057	6.761951e-01	0.170
phospho-PLA2 pathway	R-HSA-111995	6.840289e-01	0.165
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.840289e-01	0.165
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.840289e-01	0.165
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.840289e-01	0.165
MET receptor recycling	R-HSA-8875656	6.840289e-01	0.165
Signaling by MRAS-complex mutants	R-HSA-9660537	6.840289e-01	0.165
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	6.840289e-01	0.165
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.840289e-01	0.165
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.840289e-01	0.165
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	6.840289e-01	0.165
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.840289e-01	0.165
Regulation by c-FLIP	R-HSA-3371378	6.840289e-01	0.165
SLC-mediated bile acid transport	R-HSA-9958517	6.840289e-01	0.165
Dimerization of procaspase-8	R-HSA-69416	6.840289e-01	0.165
Sodium/Proton exchangers	R-HSA-425986	6.840289e-01	0.165
ROBO receptors bind AKAP5	R-HSA-9010642	6.840289e-01	0.165
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	6.903749e-01	0.161
HIV elongation arrest and recovery	R-HSA-167287	6.903749e-01	0.161
Formation of the Early Elongation Complex	R-HSA-113418	6.903749e-01	0.161
Pausing and recovery of HIV elongation	R-HSA-167290	6.903749e-01	0.161
Pyroptosis	R-HSA-5620971	6.903749e-01	0.161
Inflammasomes	R-HSA-622312	6.903749e-01	0.161
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.903749e-01	0.161
Signaling by Interleukins	R-HSA-449147	6.912101e-01	0.160
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.928243e-01	0.159
RNA Polymerase III Transcription Termination	R-HSA-73980	6.935413e-01	0.159
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.935413e-01	0.159
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.935413e-01	0.159
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	6.935413e-01	0.159
Toll-like Receptor Cascades	R-HSA-168898	6.944774e-01	0.158
ER-Phagosome pathway	R-HSA-1236974	6.964929e-01	0.157
VEGFA-VEGFR2 Pathway	R-HSA-4420097	6.970848e-01	0.157
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.012049e-01	0.154
Transport to the Golgi and subsequent modification	R-HSA-948021	7.014067e-01	0.154
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.017333e-01	0.154
Peroxisomal protein import	R-HSA-9033241	7.017333e-01	0.154
Protein localization	R-HSA-9609507	7.069716e-01	0.151
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.086185e-01	0.150
Signaling by ALK	R-HSA-201556	7.086185e-01	0.150
RAS processing	R-HSA-9648002	7.086185e-01	0.150
Signaling by Erythropoietin	R-HSA-9006335	7.088274e-01	0.149
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	7.088274e-01	0.149
mRNA Capping	R-HSA-72086	7.088274e-01	0.149
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	7.099241e-01	0.149
CASP8 activity is inhibited	R-HSA-5218900	7.154597e-01	0.145
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.154597e-01	0.145
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.154597e-01	0.145
p75NTR regulates axonogenesis	R-HSA-193697	7.154597e-01	0.145
mRNA Editing	R-HSA-75072	7.154597e-01	0.145
ARMS-mediated activation	R-HSA-170984	7.154597e-01	0.145
Regulation of signaling by NODAL	R-HSA-1433617	7.154597e-01	0.145
Unwinding of DNA	R-HSA-176974	7.154597e-01	0.145
Regulated proteolysis of p75NTR	R-HSA-193692	7.154597e-01	0.145
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.154597e-01	0.145
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.154597e-01	0.145
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.154597e-01	0.145
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.155537e-01	0.145
Pyrimidine biosynthesis	R-HSA-500753	7.155537e-01	0.145
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.155537e-01	0.145
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	7.155537e-01	0.145
Diseases of hemostasis	R-HSA-9671793	7.155537e-01	0.145
Specification of the neural plate border	R-HSA-9834899	7.155537e-01	0.145
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	7.192717e-01	0.143
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.241077e-01	0.140
HIV Transcription Elongation	R-HSA-167169	7.241077e-01	0.140
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	7.241077e-01	0.140
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	7.241077e-01	0.140
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.241077e-01	0.140
Generation of second messenger molecules	R-HSA-202433	7.241077e-01	0.140
PI3K Cascade	R-HSA-109704	7.250395e-01	0.140
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.264225e-01	0.139
PLC beta mediated events	R-HSA-112043	7.275958e-01	0.138
Signaling by NTRK1 (TRKA)	R-HSA-187037	7.311874e-01	0.136
Formation of ATP by chemiosmotic coupling	R-HSA-163210	7.362211e-01	0.133
Signal transduction by L1	R-HSA-445144	7.362211e-01	0.133
VEGFR2 mediated vascular permeability	R-HSA-5218920	7.389759e-01	0.131
HCMV Late Events	R-HSA-9610379	7.393614e-01	0.131
Disorders of transmembrane transporters	R-HSA-5619115	7.393945e-01	0.131
Diseases of carbohydrate metabolism	R-HSA-5663084	7.424383e-01	0.129
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	7.431731e-01	0.129
Trafficking of AMPA receptors	R-HSA-399719	7.431731e-01	0.129
MET activates RAP1 and RAC1	R-HSA-8875555	7.437656e-01	0.129
PI3K/AKT activation	R-HSA-198203	7.437656e-01	0.129
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.437656e-01	0.129
Defective factor IX causes hemophilia B	R-HSA-9668250	7.437656e-01	0.129
Regulation of the apoptosome activity	R-HSA-9627069	7.437656e-01	0.129
Interleukin-27 signaling	R-HSA-9020956	7.437656e-01	0.129
Receptor Mediated Mitophagy	R-HSA-8934903	7.437656e-01	0.129
Maturation of spike protein	R-HSA-9683686	7.437656e-01	0.129
Signaling by Leptin	R-HSA-2586552	7.437656e-01	0.129
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.437656e-01	0.129
Formation of apoptosome	R-HSA-111458	7.437656e-01	0.129
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.532289e-01	0.123
Intra-Golgi traffic	R-HSA-6811438	7.532289e-01	0.123
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.532289e-01	0.123
Signaling by ERBB4	R-HSA-1236394	7.535040e-01	0.123
SHC-mediated cascade:FGFR3	R-HSA-5654704	7.555934e-01	0.122
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.555934e-01	0.122
Gastrulation	R-HSA-9758941	7.575973e-01	0.121
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.590959e-01	0.120
Opioid Signalling	R-HSA-111885	7.620803e-01	0.118
Insulin receptor signalling cascade	R-HSA-74751	7.633584e-01	0.117
Ion transport by P-type ATPases	R-HSA-936837	7.633584e-01	0.117
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.642251e-01	0.117
Iron uptake and transport	R-HSA-917937	7.642251e-01	0.117
Adipogenesis	R-HSA-9843745	7.647018e-01	0.117
tRNA processing	R-HSA-72306	7.664867e-01	0.115
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.692571e-01	0.114
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.692571e-01	0.114
vRNP Assembly	R-HSA-192905	7.692571e-01	0.114
vRNA Synthesis	R-HSA-192814	7.692571e-01	0.114
RHOBTB3 ATPase cycle	R-HSA-9706019	7.692571e-01	0.114
Synthesis of PI	R-HSA-1483226	7.692571e-01	0.114
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.692571e-01	0.114
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.692571e-01	0.114
RSV-host interactions	R-HSA-9833110	7.710298e-01	0.113
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.737234e-01	0.111
Attachment and Entry	R-HSA-9694614	7.737234e-01	0.111
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.737234e-01	0.111
Ribavirin ADME	R-HSA-9755088	7.737234e-01	0.111
G-protein beta:gamma signalling	R-HSA-397795	7.742100e-01	0.111
Nuclear RNA decay	R-HSA-9930044	7.742100e-01	0.111
Cardiogenesis	R-HSA-9733709	7.742100e-01	0.111
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.742100e-01	0.111
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.822704e-01	0.107
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.864383e-01	0.104
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.885372e-01	0.103
Effects of PIP2 hydrolysis	R-HSA-114508	7.885372e-01	0.103
Miscellaneous transport and binding events	R-HSA-5223345	7.885372e-01	0.103
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.885372e-01	0.103
Selenoamino acid metabolism	R-HSA-2408522	7.902816e-01	0.102
Interferon alpha/beta signaling	R-HSA-909733	7.903305e-01	0.102
Signaling by KIT in disease	R-HSA-9669938	7.906668e-01	0.102
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.906668e-01	0.102
FGFR2 alternative splicing	R-HSA-6803529	7.906668e-01	0.102
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.906668e-01	0.102
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.906668e-01	0.102
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.906668e-01	0.102
Gamma-carboxylation of protein precursors	R-HSA-159740	7.922140e-01	0.101
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.922140e-01	0.101
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.922140e-01	0.101
Proton-coupled monocarboxylate transport	R-HSA-433692	7.922140e-01	0.101
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.922140e-01	0.101
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.922140e-01	0.101
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.922140e-01	0.101
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.922140e-01	0.101
Anchoring fibril formation	R-HSA-2214320	7.922140e-01	0.101
Netrin-1 signaling	R-HSA-373752	7.923853e-01	0.101
Signaling by VEGF	R-HSA-194138	7.927015e-01	0.101
G-protein mediated events	R-HSA-112040	7.955267e-01	0.099
Hyaluronan metabolism	R-HSA-2142845	8.021008e-01	0.096
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.021008e-01	0.096
Post-translational protein phosphorylation	R-HSA-8957275	8.035020e-01	0.095
RAF/MAP kinase cascade	R-HSA-5673001	8.036226e-01	0.095
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.037062e-01	0.095
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	8.042534e-01	0.095
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.042743e-01	0.095
Stimuli-sensing channels	R-HSA-2672351	8.044321e-01	0.095
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.064800e-01	0.093
Carnitine shuttle	R-HSA-200425	8.064800e-01	0.093
ABC transporters in lipid homeostasis	R-HSA-1369062	8.064800e-01	0.093
Formation of the ureteric bud	R-HSA-9830674	8.064800e-01	0.093
IRS-mediated signalling	R-HSA-112399	8.090820e-01	0.092
SLC transporter disorders	R-HSA-5619102	8.098329e-01	0.092
Downstream TCR signaling	R-HSA-202424	8.117413e-01	0.091
Scavenging by Class F Receptors	R-HSA-3000484	8.128881e-01	0.090
RUNX3 regulates p14-ARF	R-HSA-8951936	8.128881e-01	0.090
SHC-related events triggered by IGF1R	R-HSA-2428933	8.128881e-01	0.090
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.128881e-01	0.090
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.128881e-01	0.090
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	R-HSA-159854	8.128881e-01	0.090
Signaling by LTK	R-HSA-9842663	8.128881e-01	0.090
Synthesis of GDP-mannose	R-HSA-446205	8.128881e-01	0.090
Interleukin-35 Signalling	R-HSA-8984722	8.128881e-01	0.090
OAS antiviral response	R-HSA-8983711	8.128881e-01	0.090
PERK regulates gene expression	R-HSA-381042	8.149259e-01	0.089
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.156041e-01	0.089
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.156041e-01	0.089
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.212201e-01	0.086
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.212201e-01	0.086
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.212201e-01	0.086
Signaling by NTRKs	R-HSA-166520	8.244212e-01	0.084
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.263894e-01	0.083
RUNX2 regulates bone development	R-HSA-8941326	8.270384e-01	0.082
Extra-nuclear estrogen signaling	R-HSA-9009391	8.271543e-01	0.082
Interleukin-1 signaling	R-HSA-9020702	8.271543e-01	0.082
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.281912e-01	0.082
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.315063e-01	0.080
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.315063e-01	0.080
Frs2-mediated activation	R-HSA-170968	8.315063e-01	0.080
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.315063e-01	0.080
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.315063e-01	0.080
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	8.315063e-01	0.080
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.315063e-01	0.080
Interleukin-6 signaling	R-HSA-1059683	8.315063e-01	0.080
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.315063e-01	0.080
VEGFR2 mediated cell proliferation	R-HSA-5218921	8.349442e-01	0.078
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	8.349442e-01	0.078
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.349442e-01	0.078
Interleukin-7 signaling	R-HSA-1266695	8.349442e-01	0.078
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.349442e-01	0.078
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.357249e-01	0.078
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.362654e-01	0.078
MAPK1/MAPK3 signaling	R-HSA-5684996	8.366406e-01	0.077
Gluconeogenesis	R-HSA-70263	8.366461e-01	0.077
RAB geranylgeranylation	R-HSA-8873719	8.382193e-01	0.077
Collagen chain trimerization	R-HSA-8948216	8.384653e-01	0.077
C-type lectin receptors (CLRs)	R-HSA-5621481	8.394345e-01	0.076
Viral Infection Pathways	R-HSA-9824446	8.444845e-01	0.073
Collagen degradation	R-HSA-1442490	8.470826e-01	0.072
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.477083e-01	0.072
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.477083e-01	0.072
Myogenesis	R-HSA-525793	8.477083e-01	0.072
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.477083e-01	0.072
Abacavir ADME	R-HSA-2161522	8.477083e-01	0.072
Synthesis of IPs in the nucleus	R-HSA-1855191	8.482729e-01	0.071
FGFR3c ligand binding and activation	R-HSA-190372	8.482729e-01	0.071
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.482729e-01	0.071
Hydrolysis of LPC	R-HSA-1483115	8.482729e-01	0.071
cGMP effects	R-HSA-418457	8.482729e-01	0.071
Malate-aspartate shuttle	R-HSA-9856872	8.482729e-01	0.071
Ciprofloxacin ADME	R-HSA-9793528	8.482729e-01	0.071
Non-canonical inflammasome activation	R-HSA-9686114	8.482729e-01	0.071
HDL assembly	R-HSA-8963896	8.482729e-01	0.071
Signal regulatory protein family interactions	R-HSA-391160	8.482729e-01	0.071
Acyl chain remodeling of CL	R-HSA-1482798	8.482729e-01	0.071
Zinc transporters	R-HSA-435354	8.482729e-01	0.071
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.482729e-01	0.071
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.492339e-01	0.071
Mitochondrial protein import	R-HSA-1268020	8.555401e-01	0.068
Signaling by FGFR2 in disease	R-HSA-5655253	8.556394e-01	0.068
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.593717e-01	0.066
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.593717e-01	0.066
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.593717e-01	0.066
Signaling by BMP	R-HSA-201451	8.595677e-01	0.066
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.595677e-01	0.066
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.633720e-01	0.064
Erythropoietin activates RAS	R-HSA-9027284	8.633720e-01	0.064
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.633720e-01	0.064
G beta:gamma signalling through BTK	R-HSA-8964315	8.633720e-01	0.064
Telomere C-strand synthesis initiation	R-HSA-174430	8.633720e-01	0.064
Lysosphingolipid and LPA receptors	R-HSA-419408	8.633720e-01	0.064
Protein repair	R-HSA-5676934	8.633720e-01	0.064
Nuclear signaling by ERBB4	R-HSA-1251985	8.689065e-01	0.061
Induction of Cell-Cell Fusion	R-HSA-9733458	8.769693e-01	0.057
Prolonged ERK activation events	R-HSA-169893	8.769693e-01	0.057
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.769693e-01	0.057
Fructose catabolism	R-HSA-70350	8.769693e-01	0.057
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.769693e-01	0.057
Atorvastatin ADME	R-HSA-9754706	8.769693e-01	0.057
Virus Assembly and Release	R-HSA-168268	8.769693e-01	0.057
Mitochondrial biogenesis	R-HSA-1592230	8.774551e-01	0.057
Antigen processing-Cross presentation	R-HSA-1236975	8.794929e-01	0.056
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.805861e-01	0.055
Regulation of gene expression in beta cells	R-HSA-210745	8.807848e-01	0.055
Muscle contraction	R-HSA-397014	8.849916e-01	0.053
Integrin cell surface interactions	R-HSA-216083	8.852184e-01	0.053
G beta:gamma signalling through CDC42	R-HSA-8964616	8.892141e-01	0.051
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.892141e-01	0.051
Fibronectin matrix formation	R-HSA-1566977	8.892141e-01	0.051
Synthesis of PG	R-HSA-1483148	8.892141e-01	0.051
Galactose catabolism	R-HSA-70370	8.892141e-01	0.051
Acetylcholine regulates insulin secretion	R-HSA-399997	8.892141e-01	0.051
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.892141e-01	0.051
Downstream signaling of activated FGFR4	R-HSA-5654716	8.902445e-01	0.050
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.902445e-01	0.050
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.902445e-01	0.050
Cytosolic tRNA aminoacylation	R-HSA-379716	8.941662e-01	0.049
Downstream signal transduction	R-HSA-186763	8.990029e-01	0.046
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.002409e-01	0.046
PI3K events in ERBB2 signaling	R-HSA-1963642	9.002409e-01	0.046
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.002409e-01	0.046
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.002409e-01	0.046
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	9.002409e-01	0.046
Choline catabolism	R-HSA-6798163	9.002409e-01	0.046
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.002409e-01	0.046
Ion homeostasis	R-HSA-5578775	9.016992e-01	0.045
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.068654e-01	0.042
Signaling by Insulin receptor	R-HSA-74752	9.079233e-01	0.042
Amine ligand-binding receptors	R-HSA-375280	9.084849e-01	0.042
Proteasome assembly	R-HSA-9907900	9.084849e-01	0.042
COPII-mediated vesicle transport	R-HSA-204005	9.100524e-01	0.041
GAB1 signalosome	R-HSA-180292	9.101707e-01	0.041
G beta:gamma signalling through PLC beta	R-HSA-418217	9.101707e-01	0.041
FOXO-mediated transcription of cell death genes	R-HSA-9614657	9.101707e-01	0.041
PKA activation	R-HSA-163615	9.101707e-01	0.041
PKA activation in glucagon signalling	R-HSA-164378	9.101707e-01	0.041
Presynaptic function of Kainate receptors	R-HSA-500657	9.101707e-01	0.041
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.101707e-01	0.041
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.101707e-01	0.041
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.138750e-01	0.039
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.139207e-01	0.039
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	9.145971e-01	0.039
Somitogenesis	R-HSA-9824272	9.149647e-01	0.039
Collagen formation	R-HSA-1474290	9.173862e-01	0.037
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.173862e-01	0.037
Ion channel transport	R-HSA-983712	9.177614e-01	0.037
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.185450e-01	0.037
Crosslinking of collagen fibrils	R-HSA-2243919	9.191127e-01	0.037
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.191127e-01	0.037
Rap1 signalling	R-HSA-392517	9.191127e-01	0.037
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.191127e-01	0.037
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	9.191127e-01	0.037
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.191127e-01	0.037
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.191127e-01	0.037
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.204826e-01	0.036
Acyl chain remodelling of PC	R-HSA-1482788	9.215180e-01	0.035
Glucagon signaling in metabolic regulation	R-HSA-163359	9.215180e-01	0.035
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.215180e-01	0.035
Heme degradation	R-HSA-189483	9.215180e-01	0.035
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.240847e-01	0.034
tRNA Aminoacylation	R-HSA-379724	9.246868e-01	0.034
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.246868e-01	0.034
SARS-CoV Infections	R-HSA-9679506	9.251248e-01	0.034
Ca2+ pathway	R-HSA-4086398	9.252852e-01	0.034
Synthesis of PC	R-HSA-1483191	9.266856e-01	0.033
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.271650e-01	0.033
PI-3K cascade:FGFR4	R-HSA-5654720	9.271650e-01	0.033
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.271650e-01	0.033
VxPx cargo-targeting to cilium	R-HSA-5620916	9.271650e-01	0.033
Creatine metabolism	R-HSA-71288	9.271650e-01	0.033
Acyl chain remodelling of PI	R-HSA-1482922	9.271650e-01	0.033
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.271650e-01	0.033
Signal amplification	R-HSA-392518	9.279079e-01	0.032
eNOS activation	R-HSA-203615	9.279079e-01	0.032
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.279079e-01	0.032
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.279079e-01	0.032
Developmental Biology	R-HSA-1266738	9.285208e-01	0.032
Aquaporin-mediated transport	R-HSA-445717	9.296211e-01	0.032
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.314335e-01	0.031
Metal ion SLC transporters	R-HSA-425410	9.319726e-01	0.031
Acyl chain remodelling of PE	R-HSA-1482839	9.338038e-01	0.030
Downstream signaling of activated FGFR2	R-HSA-5654696	9.338038e-01	0.030
Downstream signaling of activated FGFR1	R-HSA-5654687	9.338038e-01	0.030
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.341234e-01	0.030
Signaling by PDGF	R-HSA-186797	9.342615e-01	0.030
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.344161e-01	0.029
G-protein activation	R-HSA-202040	9.344161e-01	0.029
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.344161e-01	0.029
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.344161e-01	0.029
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.344161e-01	0.029
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.344161e-01	0.029
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.344161e-01	0.029
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	9.344161e-01	0.029
Acyl chain remodelling of PG	R-HSA-1482925	9.344161e-01	0.029
Potential therapeutics for SARS	R-HSA-9679191	9.352039e-01	0.029
GPVI-mediated activation cascade	R-HSA-114604	9.392409e-01	0.027
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.392409e-01	0.027
FGFR2 mutant receptor activation	R-HSA-1839126	9.392409e-01	0.027
Platelet activation, signaling and aggregation	R-HSA-76002	9.395210e-01	0.027
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.402073e-01	0.027
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.403821e-01	0.027
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.409458e-01	0.026
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.409458e-01	0.026
Serine metabolism	R-HSA-977347	9.409458e-01	0.026
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.442519e-01	0.025
PI-3K cascade:FGFR1	R-HSA-5654689	9.468257e-01	0.024
Notch-HLH transcription pathway	R-HSA-350054	9.468257e-01	0.024
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.468257e-01	0.024
Neurotoxicity of clostridium toxins	R-HSA-168799	9.468257e-01	0.024
Fructose metabolism	R-HSA-5652084	9.468257e-01	0.024
LDL clearance	R-HSA-8964038	9.468257e-01	0.024
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.468257e-01	0.024
MET promotes cell motility	R-HSA-8875878	9.488678e-01	0.023
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.488678e-01	0.023
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.488678e-01	0.023
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.497899e-01	0.022
Uptake and actions of bacterial toxins	R-HSA-5339562	9.497899e-01	0.022
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.501718e-01	0.022
Regulation of PTEN mRNA translation	R-HSA-8943723	9.521204e-01	0.021
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.521204e-01	0.021
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.521204e-01	0.021
Organic anion transport by SLCO transporters	R-HSA-879518	9.521204e-01	0.021
Interleukin-20 family signaling	R-HSA-8854691	9.521204e-01	0.021
Amino acids regulate mTORC1	R-HSA-9639288	9.535084e-01	0.021
SLC-mediated transport of amino acids	R-HSA-9958863	9.535543e-01	0.021
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.567242e-01	0.019
Thromboxane signalling through TP receptor	R-HSA-428930	9.568882e-01	0.019
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.568882e-01	0.019
Complex III assembly	R-HSA-9865881	9.568882e-01	0.019
Plasma lipoprotein assembly	R-HSA-8963898	9.568882e-01	0.019
Interleukin-6 family signaling	R-HSA-6783589	9.568882e-01	0.019
Tryptophan catabolism	R-HSA-71240	9.570284e-01	0.019
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.570284e-01	0.019
Integration of energy metabolism	R-HSA-163685	9.578144e-01	0.019
G alpha (z) signalling events	R-HSA-418597	9.601855e-01	0.018
Maturation of spike protein	R-HSA-9694548	9.606255e-01	0.017
Developmental Cell Lineages	R-HSA-9734767	9.607229e-01	0.017
Cytoprotection by HMOX1	R-HSA-9707564	9.608278e-01	0.017
PI-3K cascade:FGFR2	R-HSA-5654695	9.611815e-01	0.017
G protein gated Potassium channels	R-HSA-1296059	9.611815e-01	0.017
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.611815e-01	0.017
Activation of G protein gated Potassium channels	R-HSA-1296041	9.611815e-01	0.017
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.611815e-01	0.017
Laminin interactions	R-HSA-3000157	9.611815e-01	0.017
Platelet homeostasis	R-HSA-418346	9.629485e-01	0.016
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.631758e-01	0.016
Scavenging by Class A Receptors	R-HSA-3000480	9.639326e-01	0.016
MET activates PTK2 signaling	R-HSA-8874081	9.650475e-01	0.015
Sphingolipid catabolism	R-HSA-9845614	9.650475e-01	0.015
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.650475e-01	0.015
Transmission across Chemical Synapses	R-HSA-112315	9.658336e-01	0.015
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.669719e-01	0.015
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.685287e-01	0.014
Maturation of hRSV A proteins	R-HSA-9828806	9.685287e-01	0.014
Pyrimidine catabolism	R-HSA-73621	9.697637e-01	0.013
Post-translational protein modification	R-HSA-597592	9.707580e-01	0.013
Amino acid transport across the plasma membrane	R-HSA-352230	9.709268e-01	0.013
Prednisone ADME	R-HSA-9757110	9.716633e-01	0.012
Insulin receptor recycling	R-HSA-77387	9.716633e-01	0.012
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.716633e-01	0.012
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.716633e-01	0.012
Pyrimidine salvage	R-HSA-73614	9.716633e-01	0.012
PPARA activates gene expression	R-HSA-1989781	9.719085e-01	0.012
Metabolism of polyamines	R-HSA-351202	9.731474e-01	0.012
FCERI mediated NF-kB activation	R-HSA-2871837	9.739009e-01	0.011
Platelet calcium homeostasis	R-HSA-418360	9.744859e-01	0.011
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.744859e-01	0.011
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.744859e-01	0.011
Glucagon-type ligand receptors	R-HSA-420092	9.744859e-01	0.011
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.746804e-01	0.011
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.747207e-01	0.011
Formation of paraxial mesoderm	R-HSA-9793380	9.752065e-01	0.011
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.768394e-01	0.010
DAP12 signaling	R-HSA-2424491	9.770274e-01	0.010
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.770274e-01	0.010
SHC1 events in ERBB2 signaling	R-HSA-1250196	9.770274e-01	0.010
Neurotransmitter clearance	R-HSA-112311	9.770274e-01	0.010
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.770274e-01	0.010
NCAM signaling for neurite out-growth	R-HSA-375165	9.771149e-01	0.010
Neurotransmitter release cycle	R-HSA-112310	9.772450e-01	0.010
Adaptive Immune System	R-HSA-1280218	9.785589e-01	0.009
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.788197e-01	0.009
Molecules associated with elastic fibres	R-HSA-2129379	9.793160e-01	0.009
Neddylation	R-HSA-8951664	9.805925e-01	0.009
GPER1 signaling	R-HSA-9634597	9.806355e-01	0.008
Inwardly rectifying K+ channels	R-HSA-1296065	9.813767e-01	0.008
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.831177e-01	0.007
Leishmania phagocytosis	R-HSA-9664417	9.831177e-01	0.007
Parasite infection	R-HSA-9664407	9.831177e-01	0.007
Recycling of bile acids and salts	R-HSA-159418	9.832321e-01	0.007
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.832321e-01	0.007
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.832833e-01	0.007
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.832860e-01	0.007
Azathioprine ADME	R-HSA-9748787	9.838249e-01	0.007
Mitochondrial protein degradation	R-HSA-9837999	9.839651e-01	0.007
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.847359e-01	0.007
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.850155e-01	0.007
The phototransduction cascade	R-HSA-2514856	9.852219e-01	0.006
Degradation of the extracellular matrix	R-HSA-1474228	9.868184e-01	0.006
Nucleotide biosynthesis	R-HSA-8956320	9.876724e-01	0.005
Signalling to ERKs	R-HSA-187687	9.877617e-01	0.005
Transferrin endocytosis and recycling	R-HSA-917977	9.877617e-01	0.005
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.877617e-01	0.005
Interferon gamma signaling	R-HSA-877300	9.888345e-01	0.005
Glycosphingolipid transport	R-HSA-9845576	9.889813e-01	0.005
Lysosome Vesicle Biogenesis	R-HSA-432720	9.889813e-01	0.005
Triglyceride catabolism	R-HSA-163560	9.889813e-01	0.005
Synthesis of bile acids and bile salts	R-HSA-192105	9.895658e-01	0.005
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.898890e-01	0.004
NCAM1 interactions	R-HSA-419037	9.900795e-01	0.004
SLC-mediated transport of organic cations	R-HSA-549127	9.900795e-01	0.004
Metabolism of folate and pterines	R-HSA-196757	9.900795e-01	0.004
tRNA processing in the mitochondrion	R-HSA-6785470	9.910682e-01	0.004
Elastic fibre formation	R-HSA-1566948	9.910682e-01	0.004
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.914400e-01	0.004
Synthesis of PA	R-HSA-1483166	9.914427e-01	0.004
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.919585e-01	0.004
Pentose phosphate pathway	R-HSA-71336	9.919585e-01	0.004
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.919585e-01	0.004
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.921928e-01	0.003
rRNA processing in the mitochondrion	R-HSA-8868766	9.927601e-01	0.003
Regulation of beta-cell development	R-HSA-186712	9.928785e-01	0.003
Asparagine N-linked glycosylation	R-HSA-446203	9.936876e-01	0.003
Parasitic Infection Pathways	R-HSA-9824443	9.938365e-01	0.003
Leishmania infection	R-HSA-9658195	9.938365e-01	0.003
SLC-mediated transport of organic anions	R-HSA-9955298	9.938820e-01	0.003
Heme biosynthesis	R-HSA-189451	9.941316e-01	0.003
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.943260e-01	0.002
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.946006e-01	0.002
Activation of GABAB receptors	R-HSA-991365	9.947166e-01	0.002
GABA B receptor activation	R-HSA-977444	9.947166e-01	0.002
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.947166e-01	0.002
Complex I biogenesis	R-HSA-6799198	9.950781e-01	0.002
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.950785e-01	0.002
Bile acid and bile salt metabolism	R-HSA-194068	9.957043e-01	0.002
DAP12 interactions	R-HSA-2172127	9.957177e-01	0.002
Methylation	R-HSA-156581	9.957177e-01	0.002
Hemostasis	R-HSA-109582	9.959971e-01	0.002
Peroxisomal lipid metabolism	R-HSA-390918	9.963272e-01	0.002
Regulation of insulin secretion	R-HSA-422356	9.964809e-01	0.002
Nicotinate metabolism	R-HSA-196807	9.966071e-01	0.001
Kidney development	R-HSA-9830369	9.966071e-01	0.001
Plasma lipoprotein remodeling	R-HSA-8963899	9.971869e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.974371e-01	0.001
PI Metabolism	R-HSA-1483255	9.974516e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.974675e-01	0.001
Neuronal System	R-HSA-112316	9.975739e-01	0.001
ECM proteoglycans	R-HSA-3000178	9.976666e-01	0.001
Metal ion assimilation from the host	R-HSA-9638482	9.976666e-01	0.001
Metabolism of porphyrins	R-HSA-189445	9.976666e-01	0.001
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.977201e-01	0.001
Purine catabolism	R-HSA-74259	9.978758e-01	0.001
Cardiac conduction	R-HSA-5576891	9.979435e-01	0.001
Complex IV assembly	R-HSA-9864848	9.979475e-01	0.001
Metabolism of proteins	R-HSA-392499	9.985834e-01	0.001
Paracetamol ADME	R-HSA-9753281	9.986520e-01	0.001
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.986744e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.987942e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.987942e-01	0.001
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.989032e-01	0.000
Dectin-2 family	R-HSA-5621480	9.989076e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.990041e-01	0.000
Triglyceride metabolism	R-HSA-8979227	9.991147e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.991173e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.991654e-01	0.000
Immune System	R-HSA-168256	9.991771e-01	0.000
GABA receptor activation	R-HSA-977443	9.992031e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.992031e-01	0.000
Glutathione conjugation	R-HSA-156590	9.992031e-01	0.000
Endogenous sterols	R-HSA-211976	9.992826e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.992826e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.993199e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.993515e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.994649e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.994767e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.996270e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.996824e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.997144e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.997482e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.997494e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.997582e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.997822e-01	0.000
Aspirin ADME	R-HSA-9749641	9.997970e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.998224e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.998355e-01	0.000
Potassium Channels	R-HSA-1296071	9.998388e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.998402e-01	0.000
Respiratory electron transport	R-HSA-611105	9.998480e-01	0.000
Infectious disease	R-HSA-5663205	9.998790e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998900e-01	0.000
Disease	R-HSA-1643685	9.999112e-01	0.000
Innate Immune System	R-HSA-168249	9.999139e-01	0.000
Transport of small molecules	R-HSA-382551	9.999200e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999380e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999380e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999409e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999539e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999651e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999660e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999695e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999763e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999786e-01	0.000
FCGR activation	R-HSA-2029481	9.999800e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999810e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999811e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999829e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999838e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999845e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999869e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999875e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999968e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999981e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999988e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999991e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999995e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999995e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999995e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999997e-01	0.000
Drug ADME	R-HSA-9748784	9.999997e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999998e-01	0.000
Keratinization	R-HSA-6805567	9.999999e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999999e-01	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000