MRCKB

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00264 S54 Sugiyama PGRMC1 HPR6.6 PGRMC LLGLCIFLLYKIVRGDQPAAsGDsDDDEPPPLPRLKRRDFt
O00264 S57 Sugiyama PGRMC1 HPR6.6 PGRMC LCIFLLYKIVRGDQPAAsGDsDDDEPPPLPRLKRRDFtPAE
O43255 S6 PSP SIAH2 _______________MSRPsstGPsANKPCsKQPPPQPQHt
O43255 T279 PSP SIAH2 ENFAYRLELNGNRRRLTWEAtPRSIHDGVAAAIMNSDCLVF
O60237 T646 Sugiyama PPP1R12B MYPT2 EEAESLRKARSRQARQTRRstQGVTLTDLQEAERTFSRSRA
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75665 S899 Sugiyama OFD1 CXorf5 EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P21333 S1459 Sugiyama FLNA FLN FLN1 KVPVHDVTDASKVKCsGPGLsPGMVRANLPQsFQVDTSKAG
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26038 T558 SIGNOR MSN KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P26358 S714 Sugiyama DNMT1 AIM CXXC9 DNMT MAMKEADDDEEVDDNIPEMPsPKKMHQGKKKKQNKNRIsWV
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26639 S577 Sugiyama TARS1 TARS QCATIQLDFQLPIRFNLtyVsHDGDDKKRPVIVHRAILGsV
P26639 Y575 Sugiyama TARS1 TARS YHQCATIQLDFQLPIRFNLtyVsHDGDDKKRPVIVHRAILG
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T111 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAFtADGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDP
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P42677 T74 Sugiyama RPS27 MPS1 VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P54105 S102 Sugiyama CLNS1A CLCI ICLN VNAKFEEEsKEPVADEEEEDsDDDVEPITEFRFVPSDKSAL
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826 T32 Sugiyama RAN ARA24 OK/SW-cl.81 KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q02241 S867 Sugiyama KIF23 KNSL5 MKLP1 ANEKALAKCEKYMLtHQELAsDGEIETKLIKGDIYKTRGGG
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q14155 S518 Sugiyama ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 ERYLLLFPNVLLMLSASPRMsGFIyQGKLPtTGMTITKLED
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q15052 S488 Sugiyama ARHGEF6 COOL2 KIAA0006 PIXA ERYLMLFSNVLIMLSASPRMsGFIYQGKIPIAGTVVTRLDE
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q2KHR3 T1341 Sugiyama QSER1 DGLPSDQFAKGQDtVAIEGFtDEEDtEsGGEGQYRERDEFV
Q3KQU3 S112 Sugiyama MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464 KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6FI81 T250 Sugiyama CIAPIN1 CUA001 PRO0915 ASLRAASCGEGKKRKACKNCtCGLAEELEKEKSREQMSSQP
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71UM5 T74 Sugiyama RPS27L VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9NPQ8 T441 Sugiyama RIC8A AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y5S2 S421 Sugiyama CDC42BPB KIAA1124 FTFTTESCFSDRGSLKSIMQsNtLTKDEDVQRDLEHsLQME
Q9Y5S2 S437 Sugiyama CDC42BPB KIAA1124 SIMQsNtLTKDEDVQRDLEHsLQMEAYERRIRRLEQEKLEL
Q9Y5S2 T1108 PSP CDC42BPB KIAA1124 VDVQRGIGTAYKGHVKVPKPtGVKKGWQRAYAVVCDCKLFL
Q9Y5S2 T307 Sugiyama CDC42BPB KIAA1124 VETYGKIMNHEERFQFPSHVtDVSEEAKDLIQRLICSRERR
Q9Y5S2 T423 Sugiyama CDC42BPB KIAA1124 FTTESCFSDRGSLKSIMQsNtLTKDEDVQRDLEHsLQMEAY
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.538244e-08 7.257 0 0
Cell Cycle R-HSA-1640170 4.515875e-07 6.345 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.769950e-06 5.752 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.547154e-06 5.594 0 0
Signal Transduction R-HSA-162582 4.449358e-06 5.352 1 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.609902e-06 5.443 0 0
Signaling by Interleukins R-HSA-449147 1.128065e-05 4.948 0 0
Cell Cycle Checkpoints R-HSA-69620 1.904471e-05 4.720 0 0
Axon guidance R-HSA-422475 2.354661e-05 4.628 0 0
Chromatin modifying enzymes R-HSA-3247509 4.539565e-05 4.343 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.784585e-05 4.168 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.238759e-05 4.205 0 0
Cellular Senescence R-HSA-2559583 6.253179e-05 4.204 0 0
Nervous system development R-HSA-9675108 6.763106e-05 4.170 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.944141e-05 4.226 0 0
NRAGE signals death through JNK R-HSA-193648 7.353910e-05 4.133 0 0
G alpha (12/13) signalling events R-HSA-416482 1.138877e-04 3.944 0 0
Cell Cycle, Mitotic R-HSA-69278 1.128293e-04 3.948 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.247939e-04 3.904 0 0
Chromatin organization R-HSA-4839726 1.252923e-04 3.902 0 0
RET signaling R-HSA-8853659 1.686033e-04 3.773 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.916219e-04 3.718 0 0
MAPK family signaling cascades R-HSA-5683057 1.983244e-04 3.703 0 0
RNA Polymerase II Transcription R-HSA-73857 2.240473e-04 3.650 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.411844e-04 3.618 0 0
Apoptotic execution phase R-HSA-75153 2.511553e-04 3.600 0 0
Developmental Biology R-HSA-1266738 2.959400e-04 3.529 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.088830e-04 3.510 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.984567e-04 3.400 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.979080e-04 3.400 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.761650e-04 3.425 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.913843e-04 3.309 0 0
FOXO-mediated transcription R-HSA-9614085 5.038770e-04 3.298 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.038770e-04 3.298 0 0
Formation of definitive endoderm R-HSA-9823730 5.387328e-04 3.269 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.542118e-04 3.256 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.169243e-04 3.210 0 0
Meiotic synapsis R-HSA-1221632 6.834420e-04 3.165 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.814176e-04 3.055 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.814176e-04 3.055 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.411809e-04 3.075 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.078917e-03 2.967 0 0
Regulation of TP53 Activity R-HSA-5633007 1.095438e-03 2.960 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.264016e-03 2.898 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.531419e-03 2.815 0 0
Death Receptor Signaling R-HSA-73887 1.677920e-03 2.775 0 0
Gene expression (Transcription) R-HSA-74160 1.717366e-03 2.765 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.883038e-03 2.725 0 0
Generic Transcription Pathway R-HSA-212436 1.977611e-03 2.704 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.019173e-03 2.695 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.285676e-03 2.641 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.320080e-03 2.634 0 0
Semaphorin interactions R-HSA-373755 2.238836e-03 2.650 0 0
Rap1 signalling R-HSA-392517 2.331673e-03 2.632 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.189473e-03 2.496 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.369249e-03 2.472 0 0
Ion homeostasis R-HSA-5578775 3.278852e-03 2.484 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.391308e-03 2.470 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.392835e-03 2.469 0 0
M Phase R-HSA-68886 3.521945e-03 2.453 0 0
Reproduction R-HSA-1474165 3.541939e-03 2.451 0 0
mRNA Splicing R-HSA-72172 3.705327e-03 2.431 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.771908e-03 2.423 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.125117e-03 2.385 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.153043e-03 2.382 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.301872e-03 2.366 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.620662e-03 2.335 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.497269e-03 2.347 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.620662e-03 2.335 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.620662e-03 2.335 0 0
ESR-mediated signaling R-HSA-8939211 5.003737e-03 2.301 0 0
Kinesins R-HSA-983189 4.967590e-03 2.304 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.088062e-03 2.293 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 5.573907e-03 2.254 0 0
Diseases of Telomere Maintenance R-HSA-9673013 5.573907e-03 2.254 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 5.573907e-03 2.254 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 5.573907e-03 2.254 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 5.573907e-03 2.254 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.529760e-03 2.257 0 0
FLT3 Signaling R-HSA-9607240 5.605702e-03 2.251 0 0
Cardiogenesis R-HSA-9733709 6.334172e-03 2.198 0 0
Meiosis R-HSA-1500620 6.114879e-03 2.214 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.074834e-03 2.216 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.035084e-03 2.219 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.232423e-03 2.205 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.972474e-03 2.224 0 0
mRNA 3'-end processing R-HSA-72187 6.627338e-03 2.179 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.048295e-03 2.152 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.082424e-03 2.150 0 0
Mitotic Anaphase R-HSA-68882 6.754954e-03 2.170 0 0
Neurodegenerative Diseases R-HSA-8863678 6.777190e-03 2.169 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.777190e-03 2.169 0 0
Specification of primordial germ cells R-HSA-9827857 7.826244e-03 2.106 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.886734e-03 2.103 0 0
HDMs demethylate histones R-HSA-3214842 7.886734e-03 2.103 0 0
Mitotic Prometaphase R-HSA-68877 7.892083e-03 2.103 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.961636e-03 2.099 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.835176e-03 2.054 0 0
Cell junction organization R-HSA-446728 8.865602e-03 2.052 0 0
TRP channels R-HSA-3295583 9.121297e-03 2.040 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.871914e-03 2.006 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.010765e-02 1.995 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.048806e-02 1.979 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.065634e-02 1.972 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.076616e-02 1.968 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.178573e-02 1.929 0 0
Signaling by ROBO receptors R-HSA-376176 1.264837e-02 1.898 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.300011e-02 1.886 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.304056e-02 1.885 0 0
Separation of Sister Chromatids R-HSA-2467813 1.338705e-02 1.873 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.373484e-02 1.862 0 0
Formation of axial mesoderm R-HSA-9796292 1.499489e-02 1.824 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.499489e-02 1.824 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.499489e-02 1.824 0 0
Developmental Cell Lineages R-HSA-9734767 1.516713e-02 1.819 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.499489e-02 1.824 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.527780e-02 1.816 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.585596e-02 1.800 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.607242e-02 1.794 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.621096e-02 1.790 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.662961e-02 1.779 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.822700e-02 1.739 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.822700e-02 1.739 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.822700e-02 1.739 0 0
SOS-mediated signalling R-HSA-112412 1.822700e-02 1.739 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.794817e-02 1.746 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.746177e-02 1.758 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.914204e-02 1.718 0 0
Interleukin-12 signaling R-HSA-9020591 1.925657e-02 1.715 0 0
Muscle contraction R-HSA-397014 1.945090e-02 1.711 0 0
Potassium transport channels R-HSA-1296067 2.074952e-02 1.683 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.086308e-02 1.681 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.086308e-02 1.681 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.104592e-02 1.677 0 0
HATs acetylate histones R-HSA-3214847 2.026983e-02 1.693 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.115124e-02 1.675 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.146116e-02 1.668 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.146116e-02 1.668 0 0
Diseases of programmed cell death R-HSA-9645723 1.996912e-02 1.700 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.150750e-02 1.667 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.150750e-02 1.667 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.184058e-02 1.661 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.293062e-02 1.640 0 0
S Phase R-HSA-69242 2.325531e-02 1.633 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.532033e-02 1.597 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.406993e-02 1.619 0 0
Netrin-1 signaling R-HSA-373752 2.620657e-02 1.582 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.540269e-02 1.595 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.532033e-02 1.597 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.532033e-02 1.597 0 0
Sensory processing of sound R-HSA-9659379 2.374957e-02 1.624 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.629641e-02 1.580 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.425972e-02 1.615 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.667974e-02 1.574 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.822474e-02 1.549 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.895373e-02 1.538 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.909394e-02 1.536 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.909394e-02 1.536 0 0
Calcineurin activates NFAT R-HSA-2025928 2.909394e-02 1.536 0 0
TGFBR3 expression R-HSA-9839394 2.934376e-02 1.532 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.951487e-02 1.530 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.951487e-02 1.530 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.283920e-02 1.484 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.353684e-02 1.474 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.293419e-02 1.482 0 0
Recycling pathway of L1 R-HSA-437239 3.388110e-02 1.470 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.085071e-02 1.511 0 0
Signaling by TGFBR3 R-HSA-9839373 3.117509e-02 1.506 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.283920e-02 1.484 0 0
Cell-Cell communication R-HSA-1500931 3.391128e-02 1.470 0 0
Cardiac conduction R-HSA-5576891 3.504071e-02 1.455 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.545577e-02 1.450 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.555822e-02 1.449 0 0
Signal attenuation R-HSA-74749 3.555822e-02 1.449 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.606586e-02 1.443 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.661266e-02 1.436 0 0
Packaging Of Telomere Ends R-HSA-171306 3.678659e-02 1.434 0 0
G2/M Transition R-HSA-69275 3.696957e-02 1.432 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.699521e-02 1.432 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.906845e-02 1.408 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.906845e-02 1.408 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.872039e-02 1.412 0 0
Polo-like kinase mediated events R-HSA-156711 3.906845e-02 1.408 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.906845e-02 1.408 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.994018e-02 1.399 0 0
Post NMDA receptor activation events R-HSA-438064 4.169222e-02 1.380 0 0
Apoptosis R-HSA-109581 4.308707e-02 1.366 0 0
Cellular responses to stimuli R-HSA-8953897 4.127950e-02 1.384 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.944577e-02 1.404 0 0
Interleukin-12 family signaling R-HSA-447115 4.169222e-02 1.380 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.309691e-02 1.366 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.309691e-02 1.366 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.347830e-02 1.362 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.347830e-02 1.362 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.347830e-02 1.362 0 0
Dopamine receptors R-HSA-390651 4.347830e-02 1.362 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.441405e-02 1.352 0 0
Programmed Cell Death R-HSA-5357801 4.518999e-02 1.345 0 0
Gastrulation R-HSA-9758941 4.553870e-02 1.342 0 0
Attenuation phase R-HSA-3371568 4.691534e-02 1.329 0 0
Cell-cell junction organization R-HSA-421270 4.711667e-02 1.327 0 0
IGF1R signaling cascade R-HSA-2428924 4.745680e-02 1.324 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 5.330102e-02 1.273 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 5.330102e-02 1.273 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.049487e-02 1.297 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.018708e-02 1.299 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.994616e-02 1.301 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.149317e-02 1.288 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.049487e-02 1.297 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.782144e-02 1.320 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.516291e-02 1.258 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.063230e-02 1.296 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.049487e-02 1.297 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.394192e-02 1.268 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.356239e-02 1.271 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.556125e-02 1.255 0 0
Interleukin-37 signaling R-HSA-9008059 4.994616e-02 1.301 0 0
Signaling by VEGF R-HSA-194138 4.836864e-02 1.315 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.204534e-02 1.284 0 0
IRS activation R-HSA-74713 5.712399e-02 1.243 0 0
NrCAM interactions R-HSA-447038 5.712399e-02 1.243 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.713411e-02 1.243 0 0
DNA Double Strand Break Response R-HSA-5693606 5.738683e-02 1.241 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.893138e-02 1.230 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.893138e-02 1.230 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.893138e-02 1.230 0 0
Repression of WNT target genes R-HSA-4641265 5.893138e-02 1.230 0 0
Signaling by LTK R-HSA-9842663 5.893138e-02 1.230 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.970064e-02 1.224 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.007007e-02 1.221 0 0
Signaling by MAPK mutants R-HSA-9652817 7.203271e-02 1.142 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.285980e-02 1.202 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.976817e-02 1.156 0 0
Integrin signaling R-HSA-354192 6.553761e-02 1.184 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.532344e-02 1.185 0 0
Formation of lateral plate mesoderm R-HSA-9758920 7.203271e-02 1.142 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.253662e-02 1.139 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.253662e-02 1.139 0 0
Cyclin D associated events in G1 R-HSA-69231 6.907537e-02 1.161 0 0
G1 Phase R-HSA-69236 6.907537e-02 1.161 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.236255e-02 1.140 0 0
Mitotic Prophase R-HSA-68875 6.937187e-02 1.159 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.798318e-02 1.168 0 0
IRS-mediated signalling R-HSA-112399 6.963296e-02 1.157 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.096804e-02 1.215 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.010681e-02 1.154 0 0
Signaling by TGFB family members R-HSA-9006936 6.995633e-02 1.155 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.305199e-02 1.200 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.822840e-02 1.166 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.813998e-02 1.167 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.553761e-02 1.184 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.203271e-02 1.142 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 6.798318e-02 1.168 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.553761e-02 1.184 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.711619e-02 1.173 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.285980e-02 1.202 0 0
Signaling by ALK in cancer R-HSA-9700206 6.711619e-02 1.173 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.381132e-02 1.132 0 0
Signaling by WNT R-HSA-195721 7.560697e-02 1.121 0 0
Cellular responses to stress R-HSA-2262752 7.607618e-02 1.119 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.666923e-02 1.115 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.727647e-02 1.112 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.727647e-02 1.112 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.754059e-02 1.110 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.762393e-02 1.110 0 0
HDL assembly R-HSA-8963896 7.762393e-02 1.110 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.926399e-02 1.101 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.937839e-02 1.100 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.937839e-02 1.100 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.937839e-02 1.100 0 0
Signaling by RAS mutants R-HSA-6802949 7.937839e-02 1.100 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.094030e-02 1.092 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.037641e-01 0.984 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.037641e-01 0.984 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 8.803137e-02 1.055 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.782498e-02 1.056 0 0
Phosphorylation of the APC/C R-HSA-176412 9.855589e-02 1.006 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.685028e-02 1.014 0 0
Centrosome maturation R-HSA-380287 8.989701e-02 1.046 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.043608e-01 0.981 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.360013e-02 1.078 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.360013e-02 1.078 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 9.685028e-02 1.014 0 0
Signaling by ERBB2 R-HSA-1227986 8.355546e-02 1.078 0 0
Tight junction interactions R-HSA-420029 9.269473e-02 1.033 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.682393e-02 1.014 0 0
Signaling by FGFR in disease R-HSA-1226099 8.534966e-02 1.069 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 8.803137e-02 1.055 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.469446e-02 1.072 0 0
G1/S Transition R-HSA-69206 8.854934e-02 1.053 0 0
Inhibition of PKR R-HSA-169131 1.037641e-01 0.984 0 0
PI3K Cascade R-HSA-109704 1.024108e-01 0.990 0 0
FLT3 signaling in disease R-HSA-9682385 9.006866e-02 1.045 0 0
Long-term potentiation R-HSA-9620244 9.269473e-02 1.033 0 0
Formation of the nephric duct R-HSA-9830364 9.269473e-02 1.033 0 0
Calmodulin induced events R-HSA-111933 9.006866e-02 1.045 0 0
CaM pathway R-HSA-111997 9.006866e-02 1.045 0 0
G2/M Checkpoints R-HSA-69481 9.560329e-02 1.020 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.635429e-02 1.016 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.635429e-02 1.016 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.083725e-02 1.042 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.469446e-02 1.072 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.954199e-02 1.002 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.803137e-02 1.055 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 8.469446e-02 1.072 0 0
Formation of the anterior neural plate R-HSA-9823739 8.782498e-02 1.056 0 0
Cleavage of the damaged purine R-HSA-110331 9.685028e-02 1.014 0 0
Depurination R-HSA-73927 1.038826e-01 0.983 0 0
Insulin receptor signalling cascade R-HSA-74751 1.044151e-01 0.981 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.049617e-01 0.979 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.049617e-01 0.979 0 0
Regulation of PTEN localization R-HSA-8948747 1.049617e-01 0.979 0 0
L1CAM interactions R-HSA-373760 1.064166e-01 0.973 0 0
HSF1-dependent transactivation R-HSA-3371571 1.086617e-01 0.964 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.095231e-01 0.960 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.097171e-01 0.960 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.097171e-01 0.960 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.097171e-01 0.960 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.097171e-01 0.960 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.097849e-01 0.959 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.097849e-01 0.959 0 0
Adherens junctions interactions R-HSA-418990 1.098747e-01 0.959 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.111601e-01 0.954 0 0
Ub-specific processing proteases R-HSA-5689880 1.118198e-01 0.951 0 0
EPH-Ephrin signaling R-HSA-2682334 1.124768e-01 0.949 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.515402e-01 0.819 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 1.515402e-01 0.819 0 0
Intestinal infectious diseases R-HSA-8942233 1.515402e-01 0.819 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.515402e-01 0.819 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.515402e-01 0.819 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.515402e-01 0.819 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 1.515402e-01 0.819 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.515402e-01 0.819 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.515402e-01 0.819 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.515402e-01 0.819 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.967721e-01 0.706 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.967721e-01 0.706 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 1.967721e-01 0.706 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.967721e-01 0.706 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.967721e-01 0.706 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.967721e-01 0.706 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.967721e-01 0.706 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.967721e-01 0.706 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.967721e-01 0.706 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 1.967721e-01 0.706 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.967721e-01 0.706 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.967721e-01 0.706 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.967721e-01 0.706 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.967721e-01 0.706 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.967721e-01 0.706 0 0
Invadopodia formation R-HSA-8941237 2.395953e-01 0.621 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 2.395953e-01 0.621 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.395953e-01 0.621 0 0
Activation of RAS in B cells R-HSA-1169092 1.226793e-01 0.911 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.410522e-01 0.851 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.801379e-01 0.553 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.801379e-01 0.553 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.801379e-01 0.553 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.801379e-01 0.553 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.801379e-01 0.553 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.599606e-01 0.796 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.599606e-01 0.796 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.185212e-01 0.497 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.185212e-01 0.497 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 3.185212e-01 0.497 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.185212e-01 0.497 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 3.185212e-01 0.497 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.185212e-01 0.497 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.989572e-01 0.701 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.989572e-01 0.701 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.989572e-01 0.701 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.989572e-01 0.701 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.336053e-01 0.874 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.461296e-01 0.835 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 1.461296e-01 0.835 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.461296e-01 0.835 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.188568e-01 0.660 0 0
GRB2 events in EGFR signaling R-HSA-179812 2.188568e-01 0.660 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.188568e-01 0.660 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.188568e-01 0.660 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.188568e-01 0.660 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.188568e-01 0.660 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.548601e-01 0.450 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.548601e-01 0.450 0 0
PDE3B signalling R-HSA-165160 3.548601e-01 0.450 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.548601e-01 0.450 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.548601e-01 0.450 0 0
PKB-mediated events R-HSA-109703 3.548601e-01 0.450 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.548601e-01 0.450 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.548601e-01 0.450 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.548601e-01 0.450 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.590184e-01 0.799 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.590184e-01 0.799 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.590184e-01 0.799 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.590184e-01 0.799 0 0
HIV elongation arrest and recovery R-HSA-167287 1.187153e-01 0.925 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.187153e-01 0.925 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.389129e-01 0.622 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.722380e-01 0.764 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.280210e-01 0.893 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.280210e-01 0.893 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.376205e-01 0.861 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 1.857552e-01 0.731 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.590524e-01 0.587 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.590524e-01 0.587 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.892634e-01 0.410 0 0
STAT5 Activation R-HSA-9645135 3.892634e-01 0.410 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.892634e-01 0.410 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.892634e-01 0.410 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 1.995373e-01 0.700 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.186768e-01 0.926 0 0
Erythropoietin activates RAS R-HSA-9027284 2.792096e-01 0.554 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.792096e-01 0.554 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.792096e-01 0.554 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.792096e-01 0.554 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.264263e-01 0.898 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.135523e-01 0.670 0 0
Striated Muscle Contraction R-HSA-390522 1.786629e-01 0.748 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.277691e-01 0.643 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.993253e-01 0.524 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.218339e-01 0.375 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 4.218339e-01 0.375 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.218339e-01 0.375 0 0
Netrin mediated repulsion signals R-HSA-418886 4.218339e-01 0.375 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.218339e-01 0.375 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.218339e-01 0.375 0 0
Disinhibition of SNARE formation R-HSA-114516 4.218339e-01 0.375 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.218339e-01 0.375 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.218339e-01 0.375 0 0
Translation initiation complex formation R-HSA-72649 1.285481e-01 0.891 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 2.421574e-01 0.616 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.421574e-01 0.616 0 0
HDACs deacetylate histones R-HSA-3214815 1.355418e-01 0.868 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.193469e-01 0.496 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.158062e-01 0.936 0 0
Nucleosome assembly R-HSA-774815 1.684056e-01 0.774 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.684056e-01 0.774 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.427108e-01 0.846 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.773911e-01 0.751 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.713322e-01 0.566 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.713322e-01 0.566 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.392271e-01 0.470 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.392271e-01 0.470 0 0
Type I hemidesmosome assembly R-HSA-446107 4.526694e-01 0.344 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.526694e-01 0.344 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.526694e-01 0.344 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.526694e-01 0.344 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.526694e-01 0.344 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.526694e-01 0.344 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 2.860635e-01 0.544 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.860635e-01 0.544 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.860635e-01 0.544 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.464591e-01 0.608 0 0
Signaling by Erythropoietin R-HSA-9006335 3.008558e-01 0.522 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.008558e-01 0.522 0 0
DNA methylation R-HSA-5334118 3.008558e-01 0.522 0 0
Late endosomal microautophagy R-HSA-9615710 3.008558e-01 0.522 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.582836e-01 0.588 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.973733e-01 0.705 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.973733e-01 0.705 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.784015e-01 0.422 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.447049e-01 0.611 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.822437e-01 0.549 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.943495e-01 0.531 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.939076e-01 0.712 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.404660e-01 0.619 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.187403e-01 0.497 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.601577e-01 0.444 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.165699e-01 0.380 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.165699e-01 0.380 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.165699e-01 0.380 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.749077e-01 0.426 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.352081e-01 0.361 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.352081e-01 0.361 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.677603e-01 0.572 0 0
RAF activation R-HSA-5673000 3.895884e-01 0.409 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.845332e-01 0.546 0 0
HSF1 activation R-HSA-3371511 4.186724e-01 0.378 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.186724e-01 0.378 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 3.428053e-01 0.465 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.923828e-01 0.406 0 0
Cellular response to heat stress R-HSA-3371556 3.232196e-01 0.491 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.376639e-01 0.472 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.624459e-01 0.441 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.610351e-01 0.442 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.610351e-01 0.442 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.241767e-01 0.372 0 0
Transcription of the HIV genome R-HSA-167172 1.278170e-01 0.893 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.041821e-01 0.393 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.008558e-01 0.522 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.156843e-01 0.501 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.165699e-01 0.380 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.165699e-01 0.380 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.041821e-01 0.393 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.392271e-01 0.470 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.392271e-01 0.470 0 0
HIV Transcription Elongation R-HSA-167169 1.186768e-01 0.926 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.582836e-01 0.588 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.582836e-01 0.588 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.610351e-01 0.442 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.773911e-01 0.751 0 0
Telomere Extension By Telomerase R-HSA-171319 2.860635e-01 0.544 0 0
Chromosome Maintenance R-HSA-73886 2.108651e-01 0.676 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.188568e-01 0.660 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.684056e-01 0.774 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.566878e-01 0.591 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.015490e-01 0.521 0 0
Telomere Maintenance R-HSA-157579 2.439635e-01 0.613 0 0
Signaling by EGFR R-HSA-177929 2.753949e-01 0.560 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.186768e-01 0.926 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.895084e-01 0.722 0 0
EGFR downregulation R-HSA-182971 3.305254e-01 0.481 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.344014e-01 0.872 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.713322e-01 0.566 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.784015e-01 0.422 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.976262e-01 0.401 0 0
G0 and Early G1 R-HSA-1538133 1.576428e-01 0.802 0 0
Frs2-mediated activation R-HSA-170968 2.389129e-01 0.622 0 0
MAP2K and MAPK activation R-HSA-5674135 1.344014e-01 0.872 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.344014e-01 0.872 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.575553e-01 0.803 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.584419e-01 0.588 0 0
MHC class II antigen presentation R-HSA-2132295 3.382647e-01 0.471 0 0
PI3K/AKT activation R-HSA-198203 1.599606e-01 0.796 0 0
Peptide chain elongation R-HSA-156902 4.389379e-01 0.358 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.336053e-01 0.874 0 0
Myogenesis R-HSA-525793 2.566878e-01 0.591 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.576428e-01 0.802 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.895084e-01 0.722 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.561752e-01 0.591 0 0
p75NTR signals via NF-kB R-HSA-193639 2.792096e-01 0.554 0 0
Signaling by FGFR2 R-HSA-5654738 3.523981e-01 0.453 0 0
Adrenoceptors R-HSA-390696 1.226793e-01 0.911 0 0
Activation of RAC1 R-HSA-428540 1.989572e-01 0.701 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.188568e-01 0.660 0 0
DARPP-32 events R-HSA-180024 1.280210e-01 0.893 0 0
Telomere C-strand synthesis initiation R-HSA-174430 2.792096e-01 0.554 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.792096e-01 0.554 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.218339e-01 0.375 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.193469e-01 0.496 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.117915e-01 0.674 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.526694e-01 0.344 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.784015e-01 0.422 0 0
Trafficking of AMPA receptors R-HSA-399719 3.305254e-01 0.481 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.387262e-01 0.622 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.860314e-01 0.544 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.193469e-01 0.496 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.192938e-01 0.377 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.906507e-01 0.720 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.906507e-01 0.720 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.188568e-01 0.660 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.349343e-01 0.362 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.192938e-01 0.377 0 0
Signaling by FGFR4 R-HSA-5654743 3.065197e-01 0.514 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.377790e-01 0.471 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.588271e-01 0.799 0 0
Signaling by WNT in cancer R-HSA-4791275 1.576428e-01 0.802 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.421574e-01 0.616 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.713322e-01 0.566 0 0
Prolonged ERK activation events R-HSA-169893 2.993253e-01 0.524 0 0
Signaling by FGFR3 R-HSA-5654741 3.309976e-01 0.480 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.226793e-01 0.911 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 1.226793e-01 0.911 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 1.226793e-01 0.911 0 0
Formation of the posterior neural plate R-HSA-9832991 1.792953e-01 0.746 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.188568e-01 0.660 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.680359e-01 0.775 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.218339e-01 0.375 0 0
mRNA Editing: C to U Conversion R-HSA-72200 4.218339e-01 0.375 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.392271e-01 0.470 0 0
Aggrephagy R-HSA-9646399 2.582836e-01 0.588 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.281387e-01 0.892 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.801333e-01 0.420 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.376639e-01 0.472 0 0
DAP12 signaling R-HSA-2424491 1.376205e-01 0.861 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.376205e-01 0.861 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.786629e-01 0.748 0 0
Signaling by FGFR2 in disease R-HSA-5655253 2.150043e-01 0.668 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.680359e-01 0.775 0 0
Neurexins and neuroligins R-HSA-6794361 1.151040e-01 0.939 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.410522e-01 0.851 0 0
Signaling by FGFR3 in disease R-HSA-5655332 2.713322e-01 0.566 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.749077e-01 0.426 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.218511e-01 0.914 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.801379e-01 0.553 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.792953e-01 0.746 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 3.185212e-01 0.497 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.185212e-01 0.497 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.214791e-01 0.915 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.548601e-01 0.450 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 2.792096e-01 0.554 0 0
Homology Directed Repair R-HSA-5693538 1.927800e-01 0.715 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.330443e-01 0.363 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.566878e-01 0.591 0 0
Signaling by NODAL R-HSA-1181150 1.590184e-01 0.799 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.264263e-01 0.898 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.601577e-01 0.444 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 3.361506e-01 0.473 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.722380e-01 0.764 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.892634e-01 0.410 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.193469e-01 0.496 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.976262e-01 0.401 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.749077e-01 0.426 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.349343e-01 0.362 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.361506e-01 0.473 0 0
Signalling to ERKs R-HSA-187687 2.005566e-01 0.698 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.461296e-01 0.835 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.601577e-01 0.444 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.500503e-01 0.824 0 0
Specification of the neural plate border R-HSA-9834899 1.461296e-01 0.835 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.368866e-01 0.864 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.680359e-01 0.775 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.427556e-01 0.845 0 0
Regulated Necrosis R-HSA-5218859 4.029901e-01 0.395 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.967721e-01 0.706 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.395953e-01 0.621 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.410522e-01 0.851 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.801379e-01 0.553 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.792953e-01 0.746 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 3.185212e-01 0.497 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.185212e-01 0.497 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.336053e-01 0.874 0 0
PKA activation R-HSA-163615 1.336053e-01 0.874 0 0
PKA activation in glucagon signalling R-HSA-164378 1.336053e-01 0.874 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.548601e-01 0.450 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.548601e-01 0.450 0 0
Phosphorylation of Emi1 R-HSA-176417 3.548601e-01 0.450 0 0
Formation of the Editosome R-HSA-75094 3.548601e-01 0.450 0 0
cGMP effects R-HSA-418457 2.590524e-01 0.587 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.892634e-01 0.410 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.895084e-01 0.722 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.193469e-01 0.496 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.713322e-01 0.566 0 0
Regulation by c-FLIP R-HSA-3371378 4.526694e-01 0.344 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.347585e-01 0.629 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.860635e-01 0.544 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.589243e-01 0.445 0 0
Meiotic recombination R-HSA-912446 2.247785e-01 0.648 0 0
Signaling by Insulin receptor R-HSA-74752 3.274413e-01 0.485 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.096875e-01 0.678 0 0
Integration of energy metabolism R-HSA-163685 3.311414e-01 0.480 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.590524e-01 0.587 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.404274e-01 0.853 0 0
Cellular response to chemical stress R-HSA-9711123 1.703720e-01 0.769 0 0
Amyloid fiber formation R-HSA-977225 3.620113e-01 0.441 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.218339e-01 0.375 0 0
FGFR2 mutant receptor activation R-HSA-1839126 4.186724e-01 0.378 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.712509e-01 0.430 0 0
Interleukin-1 signaling R-HSA-9020702 2.743114e-01 0.562 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.684056e-01 0.774 0 0
Transmission across Chemical Synapses R-HSA-112315 1.904267e-01 0.720 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.005566e-01 0.698 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.526694e-01 0.344 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 3.008558e-01 0.522 0 0
Inwardly rectifying K+ channels R-HSA-1296065 3.453570e-01 0.462 0 0
Opioid Signalling R-HSA-111885 2.977213e-01 0.526 0 0
Neuronal System R-HSA-112316 1.759604e-01 0.755 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.599606e-01 0.796 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.232955e-01 0.651 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.822437e-01 0.549 0 0
Ca2+ pathway R-HSA-4086398 1.604141e-01 0.795 0 0
Signaling by Hippo R-HSA-2028269 1.214791e-01 0.915 0 0
Disorders of Nervous System Development R-HSA-9697154 2.188568e-01 0.660 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.188568e-01 0.660 0 0
Pervasive developmental disorders R-HSA-9005895 2.188568e-01 0.660 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.548601e-01 0.450 0 0
G-protein beta:gamma signalling R-HSA-397795 1.680359e-01 0.775 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.218339e-01 0.375 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.822437e-01 0.549 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.822437e-01 0.549 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.601577e-01 0.444 0 0
Signalling to RAS R-HSA-167044 4.165699e-01 0.380 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.041821e-01 0.393 0 0
Selective autophagy R-HSA-9663891 4.389379e-01 0.358 0 0
Amine ligand-binding receptors R-HSA-375280 1.596052e-01 0.797 0 0
The NLRP3 inflammasome R-HSA-844456 3.784015e-01 0.422 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.536134e-01 0.814 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.582836e-01 0.588 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.188568e-01 0.660 0 0
Regulation of BACH1 activity R-HSA-9708530 2.993253e-01 0.524 0 0
Acyl chain remodelling of PS R-HSA-1482801 2.421574e-01 0.616 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.566878e-01 0.591 0 0
PLC beta mediated events R-HSA-112043 1.810103e-01 0.742 0 0
Platelet calcium homeostasis R-HSA-418360 3.008558e-01 0.522 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.494093e-01 0.457 0 0
Smooth Muscle Contraction R-HSA-445355 4.288696e-01 0.368 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.434486e-01 0.843 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.860635e-01 0.544 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.008558e-01 0.522 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.895884e-01 0.409 0 0
Interleukin-1 family signaling R-HSA-446652 1.468929e-01 0.833 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.280422e-01 0.484 0 0
Signaling by PTK6 R-HSA-8848021 1.973733e-01 0.705 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.973733e-01 0.705 0 0
Deubiquitination R-HSA-5688426 1.831481e-01 0.737 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.515402e-01 0.819 0 0
DSCAM interactions R-HSA-376172 1.967721e-01 0.706 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.395953e-01 0.621 0 0
NADE modulates death signalling R-HSA-205025 2.801379e-01 0.553 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.185212e-01 0.497 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.548601e-01 0.450 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.548601e-01 0.450 0 0
Physiological factors R-HSA-5578768 2.590524e-01 0.587 0 0
Abacavir transmembrane transport R-HSA-2161517 3.892634e-01 0.410 0 0
Ca-dependent events R-HSA-111996 1.425949e-01 0.846 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.895084e-01 0.722 0 0
Disorders of Developmental Biology R-HSA-9675151 3.193469e-01 0.496 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.193469e-01 0.496 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.773911e-01 0.751 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.526694e-01 0.344 0 0
Dimerization of procaspase-8 R-HSA-69416 4.526694e-01 0.344 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.526694e-01 0.344 0 0
Defective pyroptosis R-HSA-9710421 3.065197e-01 0.514 0 0
DAP12 interactions R-HSA-2172127 3.187403e-01 0.497 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.601577e-01 0.444 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.601577e-01 0.444 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.165699e-01 0.380 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.387127e-01 0.470 0 0
Signaling by ERBB4 R-HSA-1236394 1.673484e-01 0.776 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.621833e-01 0.581 0 0
Adaptive Immune System R-HSA-1280218 3.335692e-01 0.477 0 0
DAG and IP3 signaling R-HSA-1489509 1.684056e-01 0.774 0 0
Co-stimulation by CD28 R-HSA-389356 1.958821e-01 0.708 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.548601e-01 0.450 0 0
Protein hydroxylation R-HSA-9629569 1.590184e-01 0.799 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.392271e-01 0.470 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.526694e-01 0.344 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.404274e-01 0.853 0 0
G-protein mediated events R-HSA-112040 2.316233e-01 0.635 0 0
Pyroptosis R-HSA-5620971 2.860635e-01 0.544 0 0
Histamine receptors R-HSA-390650 2.395953e-01 0.621 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.995373e-01 0.700 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.792096e-01 0.554 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 2.822437e-01 0.549 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.330443e-01 0.363 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.193469e-01 0.496 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.589243e-01 0.445 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.190604e-01 0.924 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.675616e-01 0.573 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.187403e-01 0.497 0 0
Signaling by NTRKs R-HSA-166520 4.248021e-01 0.372 0 0
Immune System R-HSA-168256 1.978128e-01 0.704 0 0
Glycolysis R-HSA-70171 1.603995e-01 0.795 0 0
Signaling by SCF-KIT R-HSA-1433557 1.509988e-01 0.821 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.967721e-01 0.706 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.395953e-01 0.621 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.185212e-01 0.497 0 0
Estrogen biosynthesis R-HSA-193144 2.188568e-01 0.660 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 3.548601e-01 0.450 0 0
Regulation of KIT signaling R-HSA-1433559 2.590524e-01 0.587 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.892634e-01 0.410 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 4.218339e-01 0.375 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.526694e-01 0.344 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.943495e-01 0.531 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.352081e-01 0.361 0 0
Regulation of insulin secretion R-HSA-422356 3.888926e-01 0.410 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.165699e-01 0.380 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.749077e-01 0.426 0 0
Tie2 Signaling R-HSA-210993 3.589243e-01 0.445 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.784015e-01 0.422 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.352081e-01 0.361 0 0
Diseases of DNA repair R-HSA-9675135 3.432781e-01 0.464 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.226793e-01 0.911 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 3.185212e-01 0.497 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.548601e-01 0.450 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.548601e-01 0.450 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.389129e-01 0.622 0 0
Lipid particle organization R-HSA-8964572 3.892634e-01 0.410 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.792096e-01 0.554 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.218339e-01 0.375 0 0
CHL1 interactions R-HSA-447041 4.218339e-01 0.375 0 0
Synthesis of PG R-HSA-1483148 3.193469e-01 0.496 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.156843e-01 0.501 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.976262e-01 0.401 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.601577e-01 0.444 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.943495e-01 0.531 0 0
Ephrin signaling R-HSA-3928664 3.589243e-01 0.445 0 0
Ion channel transport R-HSA-983712 2.552574e-01 0.593 0 0
Interleukin-15 signaling R-HSA-8983432 2.188568e-01 0.660 0 0
MTOR signalling R-HSA-165159 2.943495e-01 0.531 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.526694e-01 0.344 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.346819e-01 0.630 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.033994e-01 0.692 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.749077e-01 0.426 0 0
Potential therapeutics for SARS R-HSA-9679191 2.160367e-01 0.665 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.409109e-01 0.356 0 0
Stimuli-sensing channels R-HSA-2672351 1.281387e-01 0.892 0 0
Glucose metabolism R-HSA-70326 2.935670e-01 0.532 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.310500e-01 0.480 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.857552e-01 0.731 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.165699e-01 0.380 0 0
Other interleukin signaling R-HSA-449836 3.784015e-01 0.422 0 0
Triglyceride catabolism R-HSA-163560 4.186724e-01 0.378 0 0
Signaling by Leptin R-HSA-2586552 1.599606e-01 0.796 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.548379e-01 0.594 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.678582e-01 0.434 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.589243e-01 0.445 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.702636e-01 0.568 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.277691e-01 0.643 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.425949e-01 0.846 0 0
Depyrimidination R-HSA-73928 1.425949e-01 0.846 0 0
FGFR2 alternative splicing R-HSA-6803529 4.535194e-01 0.343 0 0
Notch-HLH transcription pathway R-HSA-350054 4.535194e-01 0.343 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.535194e-01 0.343 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.535194e-01 0.343 0 0
mTORC1-mediated signalling R-HSA-166208 4.535194e-01 0.343 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.535194e-01 0.343 0 0
Metabolism of RNA R-HSA-8953854 4.544420e-01 0.343 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.560252e-01 0.341 0 0
Base Excision Repair R-HSA-73884 4.579721e-01 0.339 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.606153e-01 0.337 0 0
Signaling by ALK R-HSA-201556 4.613767e-01 0.336 0 0
Neutrophil degranulation R-HSA-6798695 4.624339e-01 0.335 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.647563e-01 0.333 0 0
TNF signaling R-HSA-75893 4.647563e-01 0.333 0 0
Signaling by FGFR1 R-HSA-5654736 4.647563e-01 0.333 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.674315e-01 0.330 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.680114e-01 0.330 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.714857e-01 0.327 0 0
Syndecan interactions R-HSA-3000170 4.714857e-01 0.327 0 0
Growth hormone receptor signaling R-HSA-982772 4.714857e-01 0.327 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.753123e-01 0.323 0 0
Generation of second messenger molecules R-HSA-202433 4.753123e-01 0.323 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.753123e-01 0.323 0 0
Interleukin-2 family signaling R-HSA-451927 4.753123e-01 0.323 0 0
Glycogen metabolism R-HSA-8982491 4.753123e-01 0.323 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.765978e-01 0.322 0 0
Protein ubiquitination R-HSA-8852135 4.768917e-01 0.322 0 0
Lipophagy R-HSA-9613354 4.818621e-01 0.317 0 0
CASP8 activity is inhibited R-HSA-5218900 4.818621e-01 0.317 0 0
ALK mutants bind TKIs R-HSA-9700645 4.818621e-01 0.317 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.818621e-01 0.317 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 4.818621e-01 0.317 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.818621e-01 0.317 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.818621e-01 0.317 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.818621e-01 0.317 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.818621e-01 0.317 0 0
Interleukin-1 processing R-HSA-448706 4.818621e-01 0.317 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.818621e-01 0.317 0 0
ARMS-mediated activation R-HSA-170984 4.818621e-01 0.317 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.818621e-01 0.317 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.818621e-01 0.317 0 0
mRNA Editing R-HSA-75072 4.818621e-01 0.317 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.818621e-01 0.317 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.818621e-01 0.317 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.818621e-01 0.317 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 4.818621e-01 0.317 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.818621e-01 0.317 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.818621e-01 0.317 0 0
Autophagy R-HSA-9612973 4.824963e-01 0.317 0 0
PTEN Regulation R-HSA-6807070 4.833684e-01 0.316 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.862115e-01 0.313 0 0
Signaling by NOTCH1 R-HSA-1980143 4.872260e-01 0.312 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.890790e-01 0.311 0 0
Maturation of spike protein R-HSA-9694548 4.890790e-01 0.311 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.890790e-01 0.311 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.890917e-01 0.311 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.890917e-01 0.311 0 0
Deadenylation of mRNA R-HSA-429947 4.890917e-01 0.311 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.890917e-01 0.311 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.938122e-01 0.306 0 0
Triglyceride metabolism R-HSA-8979227 4.998084e-01 0.301 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.026669e-01 0.299 0 0
HIV Transcription Initiation R-HSA-167161 5.026669e-01 0.299 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.026669e-01 0.299 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.063249e-01 0.296 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.063249e-01 0.296 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.063249e-01 0.296 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.063249e-01 0.296 0 0
G protein gated Potassium channels R-HSA-1296059 5.063249e-01 0.296 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.063249e-01 0.296 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.063249e-01 0.296 0 0
Interleukin-7 signaling R-HSA-1266695 5.063249e-01 0.296 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.094994e-01 0.293 0 0
Regulation of CDH11 function R-HSA-9762292 5.094994e-01 0.293 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 5.094994e-01 0.293 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.094994e-01 0.293 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.094994e-01 0.293 0 0
Formation of intermediate mesoderm R-HSA-9761174 5.094994e-01 0.293 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.094994e-01 0.293 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.094994e-01 0.293 0 0
Pexophagy R-HSA-9664873 5.094994e-01 0.293 0 0
Maturation of spike protein R-HSA-9683686 5.094994e-01 0.293 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.094994e-01 0.293 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.094994e-01 0.293 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.094994e-01 0.293 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 5.094994e-01 0.293 0 0
Tandem pore domain potassium channels R-HSA-1296346 5.094994e-01 0.293 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.112718e-01 0.291 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.112718e-01 0.291 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.112718e-01 0.291 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.112718e-01 0.291 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.112718e-01 0.291 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.112718e-01 0.291 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.112718e-01 0.291 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 5.112718e-01 0.291 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.133296e-01 0.290 0 0
DNA Repair R-HSA-73894 5.136373e-01 0.289 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.139707e-01 0.289 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.139707e-01 0.289 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.207371e-01 0.283 0 0
Eukaryotic Translation Termination R-HSA-72764 5.230982e-01 0.281 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.231748e-01 0.281 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.231748e-01 0.281 0 0
Hemostasis R-HSA-109582 5.272388e-01 0.278 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.277782e-01 0.278 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.277782e-01 0.278 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.292703e-01 0.276 0 0
Potassium Channels R-HSA-1296071 5.321566e-01 0.274 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.338289e-01 0.273 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.338289e-01 0.273 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.356641e-01 0.271 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.356641e-01 0.271 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.356641e-01 0.271 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.356641e-01 0.271 0 0
Signaling by APC mutants R-HSA-4839744 5.356641e-01 0.271 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 5.356641e-01 0.271 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.356641e-01 0.271 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.356641e-01 0.271 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.356641e-01 0.271 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.356641e-01 0.271 0 0
Interleukin-2 signaling R-HSA-9020558 5.356641e-01 0.271 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.356641e-01 0.271 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 5.356641e-01 0.271 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 5.356641e-01 0.271 0 0
Bicarbonate transporters R-HSA-425381 5.356641e-01 0.271 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.356641e-01 0.271 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.356641e-01 0.271 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.356641e-01 0.271 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.396334e-01 0.268 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.396334e-01 0.268 0 0
Cristae formation R-HSA-8949613 5.396334e-01 0.268 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.396334e-01 0.268 0 0
RMTs methylate histone arginines R-HSA-3214858 5.422703e-01 0.266 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.449112e-01 0.264 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.472842e-01 0.262 0 0
Signaling by FGFR R-HSA-190236 5.500527e-01 0.260 0 0
Adipogenesis R-HSA-9843745 5.548795e-01 0.256 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.550602e-01 0.256 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.550602e-01 0.256 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.550602e-01 0.256 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.550602e-01 0.256 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.550602e-01 0.256 0 0
GPCR downstream signalling R-HSA-388396 5.554241e-01 0.255 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.556944e-01 0.255 0 0
Inflammasomes R-HSA-622312 5.556944e-01 0.255 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.558557e-01 0.255 0 0
Ion transport by P-type ATPases R-HSA-936837 5.558557e-01 0.255 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.571723e-01 0.254 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.574233e-01 0.254 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.604347e-01 0.251 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.604347e-01 0.251 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.604347e-01 0.251 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.604347e-01 0.251 0 0
NF-kB is activated and signals survival R-HSA-209560 5.604347e-01 0.251 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.604347e-01 0.251 0 0
ERKs are inactivated R-HSA-202670 5.604347e-01 0.251 0 0
Signaling by AXIN mutants R-HSA-4839735 5.604347e-01 0.251 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.604347e-01 0.251 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.604347e-01 0.251 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.604347e-01 0.251 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.604347e-01 0.251 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.604347e-01 0.251 0 0
Sodium/Calcium exchangers R-HSA-425561 5.604347e-01 0.251 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.604347e-01 0.251 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 5.606557e-01 0.251 0 0
SARS-CoV Infections R-HSA-9679506 5.646876e-01 0.248 0 0
Cellular response to hypoxia R-HSA-1234174 5.666578e-01 0.247 0 0
Hedgehog 'off' state R-HSA-5610787 5.676332e-01 0.246 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.676341e-01 0.246 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.676341e-01 0.246 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.676341e-01 0.246 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.676341e-01 0.246 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 5.676341e-01 0.246 0 0
mRNA Capping R-HSA-72086 5.713535e-01 0.243 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.713535e-01 0.243 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.713535e-01 0.243 0 0
Selenocysteine synthesis R-HSA-2408557 5.762978e-01 0.239 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.799871e-01 0.237 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.838852e-01 0.234 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.838852e-01 0.234 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.838852e-01 0.234 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.838852e-01 0.234 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.838852e-01 0.234 0 0
MET activates RAS signaling R-HSA-8851805 5.838852e-01 0.234 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.838852e-01 0.234 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.838852e-01 0.234 0 0
OAS antiviral response R-HSA-8983711 5.838852e-01 0.234 0 0
PI Metabolism R-HSA-1483255 5.848750e-01 0.233 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.866077e-01 0.232 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 5.866077e-01 0.232 0 0
Activation of BH3-only proteins R-HSA-114452 5.866077e-01 0.232 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.873036e-01 0.231 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.878179e-01 0.231 0 0
Kidney development R-HSA-9830369 5.878179e-01 0.231 0 0
G alpha (q) signalling events R-HSA-416476 5.913776e-01 0.228 0 0
GPER1 signaling R-HSA-9634597 5.921147e-01 0.228 0 0
NGF-stimulated transcription R-HSA-9031628 5.921147e-01 0.228 0 0
Viral mRNA Translation R-HSA-192823 5.933623e-01 0.227 0 0
Cilium Assembly R-HSA-5617833 5.933897e-01 0.227 0 0
HIV Infection R-HSA-162906 5.949179e-01 0.226 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.993594e-01 0.222 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.014558e-01 0.221 0 0
Downstream signal transduction R-HSA-186763 6.014558e-01 0.221 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.017574e-01 0.221 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.017574e-01 0.221 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.060860e-01 0.217 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.060860e-01 0.217 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.060860e-01 0.217 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.060860e-01 0.217 0 0
FGFR4 ligand binding and activation R-HSA-190322 6.060860e-01 0.217 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.060860e-01 0.217 0 0
Chylomicron remodeling R-HSA-8963901 6.060860e-01 0.217 0 0
Mtb iron assimilation by chelation R-HSA-1222449 6.060860e-01 0.217 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 6.060860e-01 0.217 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.060860e-01 0.217 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 6.060860e-01 0.217 0 0
Maturation of nucleoprotein R-HSA-9683610 6.060860e-01 0.217 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.060860e-01 0.217 0 0
HIV Life Cycle R-HSA-162587 6.196478e-01 0.208 0 0
Platelet homeostasis R-HSA-418346 6.263680e-01 0.203 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.271036e-01 0.203 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.271036e-01 0.203 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.271036e-01 0.203 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.271036e-01 0.203 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.271036e-01 0.203 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.271036e-01 0.203 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.271036e-01 0.203 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 6.271036e-01 0.203 0 0
Ciprofloxacin ADME R-HSA-9793528 6.271036e-01 0.203 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.271036e-01 0.203 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.271036e-01 0.203 0 0
P2Y receptors R-HSA-417957 6.271036e-01 0.203 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.271036e-01 0.203 0 0
The phototransduction cascade R-HSA-2514856 6.271125e-01 0.203 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.299343e-01 0.201 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.299343e-01 0.201 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.299343e-01 0.201 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.299343e-01 0.201 0 0
HCMV Early Events R-HSA-9609690 6.301628e-01 0.201 0 0
Macroautophagy R-HSA-1632852 6.350893e-01 0.197 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.379727e-01 0.195 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.379727e-01 0.195 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.383085e-01 0.195 0 0
Orc1 removal from chromatin R-HSA-68949 6.383085e-01 0.195 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.383085e-01 0.195 0 0
Acyl chain remodelling of PC R-HSA-1482788 6.435679e-01 0.191 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.435679e-01 0.191 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.437810e-01 0.191 0 0
DCC mediated attractive signaling R-HSA-418885 6.470010e-01 0.189 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.470010e-01 0.189 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.470010e-01 0.189 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.470010e-01 0.189 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.470010e-01 0.189 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.470010e-01 0.189 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.470010e-01 0.189 0 0
Signaling by Activin R-HSA-1502540 6.470010e-01 0.189 0 0
p38MAPK events R-HSA-171007 6.470010e-01 0.189 0 0
Biotin transport and metabolism R-HSA-196780 6.470010e-01 0.189 0 0
FGFR3 ligand binding and activation R-HSA-190239 6.470010e-01 0.189 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.470010e-01 0.189 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.470010e-01 0.189 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.470010e-01 0.189 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.470010e-01 0.189 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.470010e-01 0.189 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.470010e-01 0.189 0 0
Protein methylation R-HSA-8876725 6.470010e-01 0.189 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.492668e-01 0.188 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.492668e-01 0.188 0 0
eNOS activation R-HSA-203615 6.568015e-01 0.183 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.568015e-01 0.183 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.568015e-01 0.183 0 0
Signaling by NOTCH4 R-HSA-9013694 6.568845e-01 0.183 0 0
TCR signaling R-HSA-202403 6.577747e-01 0.182 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.599867e-01 0.180 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.658378e-01 0.177 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.658378e-01 0.177 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.658378e-01 0.177 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.658378e-01 0.177 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.658378e-01 0.177 0 0
Differentiation of T cells R-HSA-9945266 6.658378e-01 0.177 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.658378e-01 0.177 0 0
Activation of SMO R-HSA-5635838 6.658378e-01 0.177 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.658378e-01 0.177 0 0
Fructose catabolism R-HSA-70350 6.658378e-01 0.177 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.658378e-01 0.177 0 0
Negative regulation of FLT3 R-HSA-9706369 6.658378e-01 0.177 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.658378e-01 0.177 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.658378e-01 0.177 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.660873e-01 0.176 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.696389e-01 0.174 0 0
Acyl chain remodelling of PE R-HSA-1482839 6.696389e-01 0.174 0 0
Oncogene Induced Senescence R-HSA-2559585 6.696389e-01 0.174 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.704676e-01 0.174 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.807098e-01 0.167 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.820848e-01 0.166 0 0
RUNX2 regulates bone development R-HSA-8941326 6.820848e-01 0.166 0 0
GPVI-mediated activation cascade R-HSA-114604 6.820848e-01 0.166 0 0
G1/S-Specific Transcription R-HSA-69205 6.820848e-01 0.166 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.836706e-01 0.165 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 6.836706e-01 0.165 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.836706e-01 0.165 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.836706e-01 0.165 0 0
Phase 2 - plateau phase R-HSA-5576893 6.836706e-01 0.165 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.836706e-01 0.165 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.836706e-01 0.165 0 0
Translation of Structural Proteins R-HSA-9694635 6.839818e-01 0.165 0 0
Interleukin-10 signaling R-HSA-6783783 6.926724e-01 0.159 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.941442e-01 0.159 0 0
Membrane Trafficking R-HSA-199991 6.955113e-01 0.158 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.965446e-01 0.157 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.967266e-01 0.157 0 0
Signaling by GPCR R-HSA-372790 6.972384e-01 0.157 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.005527e-01 0.155 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.005527e-01 0.155 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.005527e-01 0.155 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.005527e-01 0.155 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.005527e-01 0.155 0 0
Sulfide oxidation to sulfate R-HSA-1614517 7.005527e-01 0.155 0 0
Choline catabolism R-HSA-6798163 7.005527e-01 0.155 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.005527e-01 0.155 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.011914e-01 0.154 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.051177e-01 0.152 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.058231e-01 0.151 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.058231e-01 0.151 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.068403e-01 0.151 0 0
Extension of Telomeres R-HSA-180786 7.100094e-01 0.149 0 0
Regulation of beta-cell development R-HSA-186712 7.100094e-01 0.149 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.118383e-01 0.148 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.118383e-01 0.148 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.118383e-01 0.148 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.165348e-01 0.145 0 0
GAB1 signalosome R-HSA-180292 7.165348e-01 0.145 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.165348e-01 0.145 0 0
Activated point mutants of FGFR2 R-HSA-2033519 7.165348e-01 0.145 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.165348e-01 0.145 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.165348e-01 0.145 0 0
Apoptotic factor-mediated response R-HSA-111471 7.165348e-01 0.145 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 7.165348e-01 0.145 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.165348e-01 0.145 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.171277e-01 0.144 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.171277e-01 0.144 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.171277e-01 0.144 0 0
Stabilization of p53 R-HSA-69541 7.171277e-01 0.144 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.171277e-01 0.144 0 0
DNA Replication R-HSA-69306 7.185596e-01 0.144 0 0
GABA receptor activation R-HSA-977443 7.193041e-01 0.143 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.214836e-01 0.142 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.280646e-01 0.138 0 0
Diseases of Immune System R-HSA-5260271 7.280646e-01 0.138 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.280646e-01 0.138 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.283658e-01 0.138 0 0
Aquaporin-mediated transport R-HSA-445717 7.283658e-01 0.138 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.292357e-01 0.137 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.301966e-01 0.137 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.316648e-01 0.136 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.316648e-01 0.136 0 0
Maturation of nucleoprotein R-HSA-9694631 7.316648e-01 0.136 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.316648e-01 0.136 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.352814e-01 0.134 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.352814e-01 0.134 0 0
Signaling by PDGF R-HSA-186797 7.371963e-01 0.132 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.404475e-01 0.131 0 0
Ribosome-associated quality control R-HSA-9948299 7.440122e-01 0.128 0 0
Signaling by Hedgehog R-HSA-5358351 7.440122e-01 0.128 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 7.459881e-01 0.127 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.459881e-01 0.127 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.459881e-01 0.127 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.459881e-01 0.127 0 0
Pregnenolone biosynthesis R-HSA-196108 7.459881e-01 0.127 0 0
Signal transduction by L1 R-HSA-445144 7.459881e-01 0.127 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.488639e-01 0.126 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.488639e-01 0.126 0 0
Intra-Golgi traffic R-HSA-6811438 7.488639e-01 0.126 0 0
Translation of Structural Proteins R-HSA-9683701 7.488639e-01 0.126 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.540982e-01 0.123 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.540982e-01 0.123 0 0
Influenza Infection R-HSA-168255 7.555835e-01 0.122 0 0
Activation of GABAB receptors R-HSA-991365 7.587412e-01 0.120 0 0
GABA B receptor activation R-HSA-977444 7.587412e-01 0.120 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 7.587412e-01 0.120 0 0
Co-inhibition by PD-1 R-HSA-389948 7.589781e-01 0.120 0 0
FGFR2 ligand binding and activation R-HSA-190241 7.595477e-01 0.119 0 0
G-protein activation R-HSA-202040 7.595477e-01 0.119 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.595477e-01 0.119 0 0
ERK/MAPK targets R-HSA-198753 7.595477e-01 0.119 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.595477e-01 0.119 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.595477e-01 0.119 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.595477e-01 0.119 0 0
Basigin interactions R-HSA-210991 7.595477e-01 0.119 0 0
Signaling by NOTCH R-HSA-157118 7.618599e-01 0.118 0 0
Nucleotide Excision Repair R-HSA-5696398 7.669171e-01 0.115 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.669171e-01 0.115 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.682805e-01 0.114 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.721853e-01 0.112 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.723842e-01 0.112 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.723842e-01 0.112 0 0
Glutathione synthesis and recycling R-HSA-174403 7.723842e-01 0.112 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.723842e-01 0.112 0 0
SLC-mediated transport of amino acids R-HSA-9958863 7.779707e-01 0.109 0 0
Metabolism of steroid hormones R-HSA-196071 7.779707e-01 0.109 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.787919e-01 0.109 0 0
Synthesis of DNA R-HSA-69239 7.793612e-01 0.108 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.845362e-01 0.105 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.845362e-01 0.105 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 7.845362e-01 0.105 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.845362e-01 0.105 0 0
Fructose metabolism R-HSA-5652084 7.845362e-01 0.105 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.845362e-01 0.105 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.845362e-01 0.105 0 0
Signaling by KIT in disease R-HSA-9669938 7.845362e-01 0.105 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.845362e-01 0.105 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.845362e-01 0.105 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.853885e-01 0.105 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 7.854702e-01 0.105 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.863770e-01 0.104 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.863770e-01 0.104 0 0
Somitogenesis R-HSA-9824272 7.863770e-01 0.104 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.863770e-01 0.104 0 0
Neurotransmitter release cycle R-HSA-112310 7.902349e-01 0.102 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.912875e-01 0.102 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.949504e-01 0.100 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.960401e-01 0.099 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.960401e-01 0.099 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.960401e-01 0.099 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.960401e-01 0.099 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.960401e-01 0.099 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.965911e-01 0.099 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.970591e-01 0.099 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.970591e-01 0.099 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.998399e-01 0.097 0 0
HCMV Infection R-HSA-9609646 8.030764e-01 0.095 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.032180e-01 0.095 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.032180e-01 0.095 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.067173e-01 0.093 0 0
Hedgehog 'on' state R-HSA-5632684 8.067173e-01 0.093 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.069304e-01 0.093 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.069304e-01 0.093 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.069304e-01 0.093 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.069304e-01 0.093 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 8.069304e-01 0.093 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.069304e-01 0.093 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.088372e-01 0.092 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.088372e-01 0.092 0 0
Intraflagellar transport R-HSA-5620924 8.111881e-01 0.091 0 0
Toll-like Receptor Cascades R-HSA-168898 8.113429e-01 0.091 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.133944e-01 0.090 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.136225e-01 0.090 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.172399e-01 0.088 0 0
Alpha-oxidation of phytanate R-HSA-389599 8.172399e-01 0.088 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.172399e-01 0.088 0 0
Phospholipid metabolism R-HSA-1483257 8.179112e-01 0.087 0 0
Degradation of CDH1 R-HSA-9766229 8.188688e-01 0.087 0 0
Collagen formation R-HSA-1474290 8.204754e-01 0.086 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.243429e-01 0.084 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.269995e-01 0.082 0 0
Metalloprotease DUBs R-HSA-5689901 8.269995e-01 0.082 0 0
Abacavir ADME R-HSA-2161522 8.269995e-01 0.082 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.269995e-01 0.082 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.269995e-01 0.082 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.290872e-01 0.081 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.303567e-01 0.081 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.322627e-01 0.080 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.322627e-01 0.080 0 0
Viral Infection Pathways R-HSA-9824446 8.326662e-01 0.080 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.326803e-01 0.080 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.333948e-01 0.079 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.333948e-01 0.079 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.362385e-01 0.078 0 0
Triglyceride biosynthesis R-HSA-75109 8.362385e-01 0.078 0 0
Synthesis of PE R-HSA-1483213 8.362385e-01 0.078 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.362385e-01 0.078 0 0
Insulin processing R-HSA-264876 8.362385e-01 0.078 0 0
Signaling by BMP R-HSA-201451 8.362385e-01 0.078 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.381773e-01 0.077 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.402563e-01 0.076 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.402563e-01 0.076 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.402563e-01 0.076 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.449845e-01 0.073 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.468606e-01 0.072 0 0
Cellular response to starvation R-HSA-9711097 8.469204e-01 0.072 0 0
PCP/CE pathway R-HSA-4086400 8.494677e-01 0.071 0 0
RNA Polymerase I Transcription R-HSA-73864 8.494677e-01 0.071 0 0
Thyroxine biosynthesis R-HSA-209968 8.532640e-01 0.069 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.532640e-01 0.069 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 8.532640e-01 0.069 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.532640e-01 0.069 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.532640e-01 0.069 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.532640e-01 0.069 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.593296e-01 0.066 0 0
Signaling by NOTCH3 R-HSA-9012852 8.593296e-01 0.066 0 0
PKR-mediated signaling R-HSA-9833482 8.600663e-01 0.065 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.611018e-01 0.065 0 0
Activation of the pre-replicative complex R-HSA-68962 8.611018e-01 0.065 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.611018e-01 0.065 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.611018e-01 0.065 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.611018e-01 0.065 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.611018e-01 0.065 0 0
Neurotransmitter clearance R-HSA-112311 8.611018e-01 0.065 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.628972e-01 0.064 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.652096e-01 0.063 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.685213e-01 0.061 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.685213e-01 0.061 0 0
Budding and maturation of HIV virion R-HSA-162588 8.685213e-01 0.061 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.685213e-01 0.061 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.685213e-01 0.061 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 8.685213e-01 0.061 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.685213e-01 0.061 0 0
Regulation of CDH1 Function R-HSA-9764561 8.708633e-01 0.060 0 0
Synthesis of PA R-HSA-1483166 8.708633e-01 0.060 0 0
Host Interactions of HIV factors R-HSA-162909 8.732366e-01 0.059 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.747363e-01 0.058 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.755450e-01 0.058 0 0
Dual incision in TC-NER R-HSA-6782135 8.762982e-01 0.057 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.762982e-01 0.057 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.762982e-01 0.057 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.815214e-01 0.055 0 0
snRNP Assembly R-HSA-191859 8.815214e-01 0.055 0 0
Metabolism of non-coding RNA R-HSA-194441 8.815214e-01 0.055 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.815214e-01 0.055 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.821938e-01 0.054 0 0
Defective B3GALTL causes PpS R-HSA-5083635 8.821938e-01 0.054 0 0
Nuclear RNA decay R-HSA-9930044 8.821938e-01 0.054 0 0
rRNA processing R-HSA-72312 8.828386e-01 0.054 0 0
Signaling by Retinoic Acid R-HSA-5362517 8.865400e-01 0.052 0 0
Platelet degranulation R-HSA-114608 8.879784e-01 0.052 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.884878e-01 0.051 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.884878e-01 0.051 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.884878e-01 0.051 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.884878e-01 0.051 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.884878e-01 0.051 0 0
Heme degradation R-HSA-189483 8.884878e-01 0.051 0 0
Gene Silencing by RNA R-HSA-211000 8.902646e-01 0.050 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.913611e-01 0.050 0 0
Collagen degradation R-HSA-1442490 8.913611e-01 0.050 0 0
MAP kinase activation R-HSA-450294 8.913611e-01 0.050 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.921691e-01 0.050 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.939374e-01 0.049 0 0
Nuclear import of Rev protein R-HSA-180746 8.944460e-01 0.048 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.944460e-01 0.048 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.944460e-01 0.048 0 0
Signal amplification R-HSA-392518 8.944460e-01 0.048 0 0
Mitophagy R-HSA-5205647 8.944460e-01 0.048 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.944460e-01 0.048 0 0
Hyaluronan metabolism R-HSA-2142845 8.944460e-01 0.048 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.944460e-01 0.048 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.944460e-01 0.048 0 0
G alpha (s) signalling events R-HSA-418555 8.948823e-01 0.048 0 0
Heme signaling R-HSA-9707616 8.959913e-01 0.048 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.000861e-01 0.046 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.000861e-01 0.046 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.000861e-01 0.046 0 0
Regulation of Apoptosis R-HSA-169911 9.000861e-01 0.046 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.000861e-01 0.046 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.000861e-01 0.046 0 0
ER-Phagosome pathway R-HSA-1236974 9.037824e-01 0.044 0 0
RNA Polymerase III Transcription R-HSA-74158 9.054251e-01 0.043 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.054251e-01 0.043 0 0
Glycosphingolipid transport R-HSA-9845576 9.054251e-01 0.043 0 0
Circadian clock R-HSA-9909396 9.073204e-01 0.042 0 0
Inositol phosphate metabolism R-HSA-1483249 9.075704e-01 0.042 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.104792e-01 0.041 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.104792e-01 0.041 0 0
Degradation of DVL R-HSA-4641258 9.104792e-01 0.041 0 0
Degradation of AXIN R-HSA-4641257 9.104792e-01 0.041 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.104792e-01 0.041 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.104792e-01 0.041 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.104792e-01 0.041 0 0
Lysine catabolism R-HSA-71064 9.104792e-01 0.041 0 0
Collagen chain trimerization R-HSA-8948216 9.104792e-01 0.041 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.107262e-01 0.041 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.127336e-01 0.040 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.152635e-01 0.038 0 0
MET promotes cell motility R-HSA-8875878 9.152635e-01 0.038 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.152635e-01 0.038 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.186896e-01 0.037 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.197923e-01 0.036 0 0
Pentose phosphate pathway R-HSA-71336 9.197923e-01 0.036 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.197923e-01 0.036 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.197923e-01 0.036 0 0
RAS processing R-HSA-9648002 9.197923e-01 0.036 0 0
Mitochondrial protein degradation R-HSA-9837999 9.236778e-01 0.034 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.236795e-01 0.034 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.240794e-01 0.034 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.240794e-01 0.034 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.240794e-01 0.034 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.240794e-01 0.034 0 0
Interleukin-17 signaling R-HSA-448424 9.269225e-01 0.033 0 0
Mitochondrial biogenesis R-HSA-1592230 9.277227e-01 0.033 0 0
Peptide hormone metabolism R-HSA-2980736 9.277227e-01 0.033 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.281376e-01 0.032 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.281376e-01 0.032 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.281376e-01 0.032 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.281376e-01 0.032 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.281376e-01 0.032 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.281376e-01 0.032 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.294234e-01 0.032 0 0
Metabolism of cofactors R-HSA-8978934 9.301133e-01 0.031 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.319790e-01 0.031 0 0
Heme biosynthesis R-HSA-189451 9.319790e-01 0.031 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.321447e-01 0.031 0 0
Selenoamino acid metabolism R-HSA-2408522 9.327958e-01 0.030 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.331721e-01 0.030 0 0
Innate Immune System R-HSA-168249 9.377108e-01 0.028 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.389134e-01 0.027 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.390576e-01 0.027 0 0
TBC/RABGAPs R-HSA-8854214 9.390576e-01 0.027 0 0
Leishmania infection R-HSA-9658195 9.394617e-01 0.027 0 0
Parasitic Infection Pathways R-HSA-9824443 9.394617e-01 0.027 0 0
Proteasome assembly R-HSA-9907900 9.423159e-01 0.026 0 0
Surfactant metabolism R-HSA-5683826 9.423159e-01 0.026 0 0
UCH proteinases R-HSA-5689603 9.441844e-01 0.025 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.454002e-01 0.024 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.454002e-01 0.024 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.454002e-01 0.024 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.466548e-01 0.024 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.483198e-01 0.023 0 0
ABC transporter disorders R-HSA-5619084 9.490208e-01 0.023 0 0
Cholesterol biosynthesis R-HSA-191273 9.490208e-01 0.023 0 0
Integrin cell surface interactions R-HSA-216083 9.490208e-01 0.023 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.496674e-01 0.022 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.510834e-01 0.022 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.510834e-01 0.022 0 0
Synthesis of PC R-HSA-1483191 9.510834e-01 0.022 0 0
Neddylation R-HSA-8951664 9.525393e-01 0.021 0 0
Disease R-HSA-1643685 9.532676e-01 0.021 0 0
Signaling by MET R-HSA-6806834 9.534559e-01 0.021 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.536994e-01 0.021 0 0
Metal ion SLC transporters R-HSA-425410 9.536994e-01 0.021 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.555327e-01 0.020 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.561756e-01 0.019 0 0
DNA Damage Bypass R-HSA-73893 9.561756e-01 0.019 0 0
G alpha (i) signalling events R-HSA-418594 9.585813e-01 0.018 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.594235e-01 0.018 0 0
Complex IV assembly R-HSA-9864848 9.607383e-01 0.017 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.607383e-01 0.017 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.612444e-01 0.017 0 0
HCMV Late Events R-HSA-9610379 9.625810e-01 0.017 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.628385e-01 0.016 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.646537e-01 0.016 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.646537e-01 0.016 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.648264e-01 0.016 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.658270e-01 0.015 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.662484e-01 0.015 0 0
G alpha (z) signalling events R-HSA-418597 9.684893e-01 0.014 0 0
Paracetamol ADME R-HSA-9753281 9.684893e-01 0.014 0 0
Vesicle-mediated transport R-HSA-5653656 9.695944e-01 0.013 0 0
Extracellular matrix organization R-HSA-1474244 9.701651e-01 0.013 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.701753e-01 0.013 0 0
Digestion R-HSA-8935690 9.701753e-01 0.013 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.701753e-01 0.013 0 0
Dectin-2 family R-HSA-5621480 9.717712e-01 0.012 0 0
Downstream TCR signaling R-HSA-202424 9.719620e-01 0.012 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.722281e-01 0.012 0 0
SLC transporter disorders R-HSA-5619102 9.737768e-01 0.012 0 0
Rab regulation of trafficking R-HSA-9007101 9.744558e-01 0.011 0 0
IRE1alpha activates chaperones R-HSA-381070 9.744569e-01 0.011 0 0
Peroxisomal protein import R-HSA-9033241 9.747115e-01 0.011 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.747115e-01 0.011 0 0
Glutathione conjugation R-HSA-156590 9.760649e-01 0.011 0 0
Metabolism of polyamines R-HSA-351202 9.760649e-01 0.011 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.772691e-01 0.010 0 0
tRNA processing in the nucleus R-HSA-6784531 9.785585e-01 0.009 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.785585e-01 0.009 0 0
Mitochondrial protein import R-HSA-1268020 9.785585e-01 0.009 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.796669e-01 0.009 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.796669e-01 0.009 0 0
Digestion and absorption R-HSA-8963743 9.797062e-01 0.009 0 0
Visual phototransduction R-HSA-2187338 9.797789e-01 0.009 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.807204e-01 0.008 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.807925e-01 0.008 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.818208e-01 0.008 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.837153e-01 0.007 0 0
Nicotinate metabolism R-HSA-196807 9.837153e-01 0.007 0 0
Protein localization R-HSA-9609507 9.840349e-01 0.007 0 0
ABC-family proteins mediated transport R-HSA-382556 9.840390e-01 0.007 0 0
PPARA activates gene expression R-HSA-1989781 9.852540e-01 0.006 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.861937e-01 0.006 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.863845e-01 0.006 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.869330e-01 0.006 0 0
Metabolism of porphyrins R-HSA-189445 9.869330e-01 0.006 0 0
ECM proteoglycans R-HSA-3000178 9.869330e-01 0.006 0 0
Retinoid metabolism and transport R-HSA-975634 9.869330e-01 0.006 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.874138e-01 0.006 0 0
RSV-host interactions R-HSA-9833110 9.874138e-01 0.006 0 0
Interferon gamma signaling R-HSA-877300 9.874323e-01 0.005 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.876198e-01 0.005 0 0
Iron uptake and transport R-HSA-917937 9.895156e-01 0.005 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.895156e-01 0.005 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.907581e-01 0.004 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.915882e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.916373e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.916373e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.916373e-01 0.004 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.924655e-01 0.003 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.929243e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.932582e-01 0.003 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.932890e-01 0.003 0 0
Interferon Signaling R-HSA-913531 9.934016e-01 0.003 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.936131e-01 0.003 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.941261e-01 0.003 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.945861e-01 0.002 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.948763e-01 0.002 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.951510e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.956458e-01 0.002 0 0
Metabolism of steroids R-HSA-8957322 9.960294e-01 0.002 0 0
Protein folding R-HSA-391251 9.963189e-01 0.002 0 0
Infectious disease R-HSA-5663205 9.970206e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.974976e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.976318e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.978988e-01 0.001 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.978990e-01 0.001 0 0
tRNA processing R-HSA-72306 9.980096e-01 0.001 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.982027e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.983934e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.987785e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.988441e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.990480e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.990731e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.994041e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.995497e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.995816e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.996930e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.997211e-01 0.000 0 0
Translation R-HSA-72766 9.997588e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.997915e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.998756e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999348e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999478e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999656e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999807e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999841e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999849e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999862e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999889e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999916e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999938e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999951e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999980e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999980e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999994e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999999e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999999e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 8.970602e-14 13.047 0 0
Cell Cycle Checkpoints R-HSA-69620 1.982525e-12 11.703 0 0
Cell Cycle, Mitotic R-HSA-69278 8.522960e-12 11.069 0 0
Metabolism of RNA R-HSA-8953854 9.632628e-12 11.016 0 0
G2/M Checkpoints R-HSA-69481 3.464051e-11 10.460 0 0
M Phase R-HSA-68886 7.124423e-11 10.147 0 0
Chromatin organization R-HSA-4839726 2.806713e-10 9.552 0 0
Chromatin modifying enzymes R-HSA-3247509 5.070843e-10 9.295 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.309509e-09 8.883 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.604567e-09 8.443 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.211098e-08 7.917 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.419109e-08 7.848 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.518836e-08 7.818 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.367297e-08 7.626 0 0
Cellular response to heat stress R-HSA-3371556 4.612366e-08 7.336 0 0
DNA Double Strand Break Response R-HSA-5693606 5.614649e-08 7.251 0 0
Cellular responses to stimuli R-HSA-8953897 6.902858e-08 7.161 0 0
Cellular responses to stress R-HSA-2262752 7.001699e-08 7.155 0 0
Homology Directed Repair R-HSA-5693538 1.517029e-07 6.819 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.832711e-07 6.737 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.464911e-07 6.608 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.464911e-07 6.608 0 0
Mitotic Prophase R-HSA-68875 2.291592e-07 6.640 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.642473e-07 6.578 0 0
Apoptotic execution phase R-HSA-75153 2.635941e-07 6.579 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.420567e-07 6.466 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.674271e-07 6.246 0 0
Mitotic Anaphase R-HSA-68882 1.007965e-06 5.997 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.129764e-06 5.947 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.158221e-06 5.936 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.195373e-06 5.922 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.460717e-06 5.835 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.608335e-06 5.794 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.865819e-06 5.729 0 0
HATs acetylate histones R-HSA-3214847 2.125218e-06 5.673 0 0
Cellular Senescence R-HSA-2559583 2.666450e-06 5.574 0 0
Translation initiation complex formation R-HSA-72649 3.180203e-06 5.498 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.251354e-06 5.488 0 0
Nervous system development R-HSA-9675108 3.426450e-06 5.465 0 0
Separation of Sister Chromatids R-HSA-2467813 3.725802e-06 5.429 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.181742e-06 5.379 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.157463e-06 5.288 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.030588e-06 5.220 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.012684e-06 5.221 0 0
Axon guidance R-HSA-422475 6.332861e-06 5.198 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.182699e-06 5.144 0 0
Estrogen-dependent gene expression R-HSA-9018519 7.216759e-06 5.142 0 0
Regulation of TP53 Activity R-HSA-5633007 8.620359e-06 5.064 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.943664e-06 5.048 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 9.324885e-06 5.030 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.043030e-05 4.982 0 0
HSF1-dependent transactivation R-HSA-3371571 1.213007e-05 4.916 0 0
HDACs deacetylate histones R-HSA-3214815 1.215805e-05 4.915 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.364913e-05 4.865 0 0
Cell junction organization R-HSA-446728 1.404945e-05 4.852 0 0
Cell-Cell communication R-HSA-1500931 1.575624e-05 4.803 0 0
Membrane Trafficking R-HSA-199991 1.627064e-05 4.789 0 0
Signaling by ROBO receptors R-HSA-376176 1.589137e-05 4.799 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.726798e-05 4.763 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.816453e-05 4.741 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.116169e-05 4.674 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.510441e-05 4.600 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.486563e-05 4.604 0 0
DNA Replication R-HSA-69306 2.570631e-05 4.590 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.804468e-05 4.552 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.935913e-05 4.532 0 0
Mitotic Prometaphase R-HSA-68877 3.023057e-05 4.520 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.091374e-05 4.510 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.369552e-05 4.472 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.369552e-05 4.472 0 0
Attenuation phase R-HSA-3371568 3.369552e-05 4.472 0 0
mRNA Splicing R-HSA-72172 3.783093e-05 4.422 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.045507e-05 4.393 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.135885e-05 4.383 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.512537e-05 4.259 0 0
Meiotic synapsis R-HSA-1221632 5.675973e-05 4.246 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.486668e-05 4.261 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.456531e-05 4.263 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.684727e-05 4.245 0 0
Nucleosome assembly R-HSA-774815 5.922907e-05 4.227 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.922907e-05 4.227 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 6.231851e-05 4.205 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 6.231851e-05 4.205 0 0
Influenza Infection R-HSA-168255 6.550926e-05 4.184 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.656073e-05 4.116 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.666837e-05 4.115 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.833617e-05 4.054 0 0
Activation of ATR in response to replication stress R-HSA-176187 9.516594e-05 4.022 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.050065e-04 3.979 0 0
Signaling by ERBB2 R-HSA-1227986 1.069868e-04 3.971 0 0
Kinesins R-HSA-983189 1.069868e-04 3.971 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.089336e-04 3.963 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.089336e-04 3.963 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.139040e-04 3.943 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.313398e-04 3.882 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.449203e-04 3.839 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.593102e-04 3.798 0 0
Peptide chain elongation R-HSA-156902 1.616756e-04 3.791 0 0
Diseases of programmed cell death R-HSA-9645723 1.616756e-04 3.791 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.801348e-04 3.744 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.006931e-04 3.697 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.241818e-04 3.649 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.241664e-04 3.649 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.385610e-04 3.622 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.450282e-04 3.611 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.453147e-04 3.610 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.636616e-04 3.579 0 0
rRNA processing R-HSA-72312 2.544105e-04 3.594 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.562016e-04 3.591 0 0
Defective pyroptosis R-HSA-9710421 2.772105e-04 3.557 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.924627e-04 3.534 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.973260e-04 3.527 0 0
HSF1 activation R-HSA-3371511 2.924627e-04 3.534 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.920874e-04 3.534 0 0
HIV Life Cycle R-HSA-162587 3.032478e-04 3.518 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.074874e-04 3.512 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.357117e-04 3.474 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.363520e-04 3.473 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.548039e-04 3.450 0 0
Striated Muscle Contraction R-HSA-390522 3.831879e-04 3.417 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.780855e-04 3.422 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.832729e-04 3.416 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.909309e-04 3.408 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.656799e-04 3.332 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.663142e-04 3.331 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.663142e-04 3.331 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.525370e-04 3.344 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.845508e-04 3.315 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.672138e-04 3.330 0 0
EGFR downregulation R-HSA-182971 5.012437e-04 3.300 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.012437e-04 3.300 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.242367e-04 3.280 0 0
Adherens junctions interactions R-HSA-418990 5.253046e-04 3.280 0 0
Gene Silencing by RNA R-HSA-211000 5.301755e-04 3.276 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.660716e-04 3.247 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.816044e-04 3.235 0 0
Ribosome-associated quality control R-HSA-9948299 5.913937e-04 3.228 0 0
L1CAM interactions R-HSA-373760 6.138431e-04 3.212 0 0
ESR-mediated signaling R-HSA-8939211 6.794821e-04 3.168 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.361289e-04 3.196 0 0
Aggrephagy R-HSA-9646399 7.765866e-04 3.110 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.765866e-04 3.110 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.765866e-04 3.110 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.147990e-04 3.089 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.168751e-04 3.088 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.464586e-04 3.072 0 0
DNA methylation R-HSA-5334118 8.601509e-04 3.065 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.601509e-04 3.065 0 0
Host Interactions of HIV factors R-HSA-162909 8.946675e-04 3.048 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.118117e-03 2.952 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.161051e-03 2.935 0 0
Eukaryotic Translation Termination R-HSA-72764 1.350945e-03 2.869 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.373279e-03 2.862 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.374759e-03 2.862 0 0
Nuclear import of Rev protein R-HSA-180746 1.374759e-03 2.862 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.374759e-03 2.862 0 0
Cell-cell junction organization R-HSA-421270 1.414846e-03 2.849 0 0
Negative regulation of MET activity R-HSA-6807004 1.423555e-03 2.847 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.438027e-03 2.842 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.438027e-03 2.842 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.463698e-03 2.835 0 0
Packaging Of Telomere Ends R-HSA-171306 1.475911e-03 2.831 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.475911e-03 2.831 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.608233e-03 2.794 0 0
Signaling by EGFR R-HSA-177929 1.628305e-03 2.788 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.541351e-03 2.812 0 0
Apoptosis R-HSA-109581 1.648980e-03 2.783 0 0
Recycling pathway of L1 R-HSA-437239 1.662603e-03 2.779 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.667604e-03 2.778 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.706481e-03 2.768 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.728656e-03 2.762 0 0
Meiosis R-HSA-1500620 1.736679e-03 2.760 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.768281e-03 2.752 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.813167e-03 2.742 0 0
mRNA 3'-end processing R-HSA-72187 1.813167e-03 2.742 0 0
Signaling by Hippo R-HSA-2028269 1.821271e-03 2.740 0 0
HIV Infection R-HSA-162906 1.928696e-03 2.715 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.946054e-03 2.711 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.983544e-03 2.703 0 0
Signaling by ALK in cancer R-HSA-9700206 1.983544e-03 2.703 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.991650e-03 2.701 0 0
Chromosome Maintenance R-HSA-73886 2.126131e-03 2.672 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.229884e-03 2.652 0 0
G2/M Transition R-HSA-69275 2.289653e-03 2.640 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.303255e-03 2.638 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.308953e-03 2.637 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.442791e-03 2.612 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.458003e-03 2.609 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.561619e-03 2.591 0 0
RNA Polymerase I Transcription R-HSA-73864 2.600668e-03 2.585 0 0
snRNP Assembly R-HSA-191859 2.721048e-03 2.565 0 0
Metabolism of non-coding RNA R-HSA-194441 2.721048e-03 2.565 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.069262e-03 2.513 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.069262e-03 2.513 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.069262e-03 2.513 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.069262e-03 2.513 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.069262e-03 2.513 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.069262e-03 2.513 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.069262e-03 2.513 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.069262e-03 2.513 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.069262e-03 2.513 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.069262e-03 2.513 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.069262e-03 2.513 0 0
Activation of the pre-replicative complex R-HSA-68962 3.087566e-03 2.510 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.978657e-03 2.526 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.885557e-03 2.540 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.200395e-03 2.495 0 0
mTORC1-mediated signalling R-HSA-166208 3.358294e-03 2.474 0 0
Protein ubiquitination R-HSA-8852135 3.421638e-03 2.466 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.449564e-03 2.462 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.575265e-03 2.447 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.575265e-03 2.447 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.671985e-03 2.435 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.748310e-03 2.426 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.938515e-03 2.405 0 0
Interleukin-12 signaling R-HSA-9020591 3.938515e-03 2.405 0 0
Regulation of PTEN localization R-HSA-8948747 3.942567e-03 2.404 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.033087e-03 2.394 0 0
Regulation of CDH1 Function R-HSA-9764561 4.251212e-03 2.371 0 0
tRNA processing in the nucleus R-HSA-6784531 4.372065e-03 2.359 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.393748e-03 2.357 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.397286e-03 2.357 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.453728e-03 2.351 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.624868e-03 2.335 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.802074e-03 2.319 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.932620e-03 2.307 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.542586e-03 2.256 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.466718e-03 2.262 0 0
Selective autophagy R-HSA-9663891 5.760275e-03 2.240 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.172265e-03 2.286 0 0
Selenocysteine synthesis R-HSA-2408557 5.426599e-03 2.265 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.797348e-03 2.237 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.797348e-03 2.237 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.805463e-03 2.236 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.805463e-03 2.236 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.914517e-03 2.228 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.004074e-03 2.222 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.186770e-03 2.209 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.484972e-03 2.188 0 0
Synthesis of DNA R-HSA-69239 6.595795e-03 2.181 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 6.684865e-03 2.175 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 6.790603e-03 2.168 0 0
Viral mRNA Translation R-HSA-192823 6.792496e-03 2.168 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.986334e-03 2.156 0 0
Interferon Signaling R-HSA-913531 7.061299e-03 2.151 0 0
Autophagy R-HSA-9612973 7.210126e-03 2.142 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.274252e-03 2.138 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.274252e-03 2.138 0 0
Integration of provirus R-HSA-162592 7.337325e-03 2.134 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.434316e-03 2.129 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.442512e-03 2.128 0 0
Meiotic recombination R-HSA-912446 7.515340e-03 2.124 0 0
Amyloid fiber formation R-HSA-977225 7.599853e-03 2.119 0 0
Programmed Cell Death R-HSA-5357801 7.601537e-03 2.119 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.768415e-03 2.110 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.794049e-03 2.108 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.962432e-03 2.099 0 0
MTOR signalling R-HSA-165159 8.235415e-03 2.084 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.235415e-03 2.084 0 0
Depyrimidination R-HSA-73928 8.235415e-03 2.084 0 0
HCMV Early Events R-HSA-9609690 8.401740e-03 2.076 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.837693e-03 2.007 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.426531e-03 2.026 0 0
Orc1 removal from chromatin R-HSA-68949 8.762522e-03 2.057 0 0
DNA Repair R-HSA-73894 9.700055e-03 2.013 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.928870e-03 2.049 0 0
Oncogene Induced Senescence R-HSA-2559585 1.048338e-02 1.979 0 0
Gene expression (Transcription) R-HSA-74160 1.058531e-02 1.975 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.075761e-02 1.968 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.089405e-02 1.963 0 0
Telomere Maintenance R-HSA-157579 1.113815e-02 1.953 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.113815e-02 1.953 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.119139e-02 1.951 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.141217e-02 1.943 0 0
Macroautophagy R-HSA-1632852 1.224687e-02 1.912 0 0
PKR-mediated signaling R-HSA-9833482 1.254393e-02 1.902 0 0
Ub-specific processing proteases R-HSA-5689880 1.259224e-02 1.900 0 0
Formation of definitive endoderm R-HSA-9823730 1.274498e-02 1.895 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.319630e-02 1.880 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.324247e-02 1.878 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.324247e-02 1.878 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.324247e-02 1.878 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.332448e-02 1.875 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.332448e-02 1.875 0 0
Vesicle-mediated transport R-HSA-5653656 1.372499e-02 1.862 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.457750e-02 1.836 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.457750e-02 1.836 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.481251e-02 1.829 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.481251e-02 1.829 0 0
Cleavage of the damaged purine R-HSA-110331 1.481251e-02 1.829 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.488216e-02 1.827 0 0
S Phase R-HSA-69242 1.496465e-02 1.825 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.541532e-02 1.812 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.591277e-02 1.798 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.599944e-02 1.796 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.599944e-02 1.796 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.685655e-02 1.773 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.685655e-02 1.773 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.685655e-02 1.773 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.909598e-02 1.719 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.683814e-02 1.774 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.784694e-02 1.748 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.923188e-02 1.716 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.885363e-02 1.725 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.697774e-02 1.770 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.969964e-02 1.706 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.782794e-02 1.749 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.782794e-02 1.749 0 0
Semaphorin interactions R-HSA-373755 1.969964e-02 1.706 0 0
G alpha (12/13) signalling events R-HSA-416482 1.815563e-02 1.741 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.871217e-02 1.728 0 0
Interleukin-12 family signaling R-HSA-447115 1.697774e-02 1.770 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.741064e-02 1.759 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.923188e-02 1.716 0 0
Depurination R-HSA-73927 1.743298e-02 1.759 0 0
Dual Incision in GG-NER R-HSA-5696400 1.991798e-02 1.701 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.038969e-02 1.691 0 0
Smooth Muscle Contraction R-HSA-445355 2.039829e-02 1.690 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.058826e-02 1.686 0 0
Cellular response to starvation R-HSA-9711097 2.093449e-02 1.679 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.158292e-02 1.666 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.158292e-02 1.666 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.166485e-02 1.664 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.172348e-02 1.663 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.272755e-02 1.643 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.272755e-02 1.643 0 0
Base Excision Repair R-HSA-73884 2.308868e-02 1.637 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.321799e-02 1.634 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.352457e-02 1.628 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.352457e-02 1.628 0 0
Translesion synthesis by REV1 R-HSA-110312 2.352457e-02 1.628 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.415793e-02 1.617 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.415793e-02 1.617 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.415793e-02 1.617 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.415793e-02 1.617 0 0
PTEN Regulation R-HSA-6807070 2.584331e-02 1.588 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.588158e-02 1.587 0 0
DNA strand elongation R-HSA-69190 2.683964e-02 1.571 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.683964e-02 1.571 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.707934e-02 1.567 0 0
Translesion Synthesis by POLH R-HSA-110320 2.707934e-02 1.567 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.730694e-02 1.564 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.122599e-02 1.505 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.122599e-02 1.505 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.215536e-02 1.493 0 0
Translesion synthesis by POLI R-HSA-5656121 2.983347e-02 1.525 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.319171e-02 1.479 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.076085e-02 1.512 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.109069e-02 1.507 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.444855e-02 1.463 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.338232e-02 1.476 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.377857e-02 1.471 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.972562e-02 1.527 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.215536e-02 1.493 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.338232e-02 1.476 0 0
Protein folding R-HSA-391251 3.077263e-02 1.512 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.323274e-02 1.478 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.286542e-02 1.483 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.146282e-02 1.502 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.323274e-02 1.478 0 0
Signal Transduction R-HSA-162582 3.222827e-02 1.492 1 0
Unwinding of DNA R-HSA-176974 3.323274e-02 1.478 0 0
Neurodegenerative Diseases R-HSA-8863678 3.520217e-02 1.453 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.520217e-02 1.453 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.451785e-02 1.462 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.200568e-02 1.495 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.456081e-02 1.461 0 0
Diseases of DNA repair R-HSA-9675135 3.109069e-02 1.507 0 0
Maturation of protein E R-HSA-9694493 3.122599e-02 1.505 0 0
Maturation of protein E R-HSA-9683683 3.122599e-02 1.505 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.529994e-02 1.452 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.529994e-02 1.452 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.529994e-02 1.452 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.529994e-02 1.452 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.529994e-02 1.452 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.529994e-02 1.452 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.533363e-02 1.452 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.533363e-02 1.452 0 0
Sensory processing of sound R-HSA-9659379 3.534917e-02 1.452 0 0
Co-inhibition by PD-1 R-HSA-389948 3.596357e-02 1.444 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.614376e-02 1.442 0 0
Signaling by PTK6 R-HSA-8848021 3.614376e-02 1.442 0 0
Late endosomal microautophagy R-HSA-9615710 3.625492e-02 1.441 0 0
Disorders of Developmental Biology R-HSA-9675151 3.719185e-02 1.430 0 0
Translesion synthesis by POLK R-HSA-5655862 3.719185e-02 1.430 0 0
Inhibition of nitric oxide production R-HSA-9636249 3.806554e-02 1.419 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.878291e-02 1.411 0 0
Signaling by MET R-HSA-6806834 3.894417e-02 1.410 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.944298e-02 1.404 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.944298e-02 1.404 0 0
Deubiquitination R-HSA-5688426 4.074463e-02 1.390 0 0
Centrosome maturation R-HSA-380287 4.080399e-02 1.389 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.080399e-02 1.389 0 0
Formation of axial mesoderm R-HSA-9796292 4.108648e-02 1.386 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.108648e-02 1.386 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.185026e-02 1.378 0 0
Stabilization of p53 R-HSA-69541 4.185026e-02 1.378 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.271295e-02 1.369 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.349501e-02 1.362 0 0
Reproduction R-HSA-1474165 4.399126e-02 1.357 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.417554e-02 1.355 0 0
2-LTR circle formation R-HSA-164843 4.417554e-02 1.355 0 0
Josephin domain DUBs R-HSA-5689877 4.417554e-02 1.355 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.417554e-02 1.355 0 0
Pexophagy R-HSA-9664873 4.417554e-02 1.355 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.466008e-02 1.350 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.473966e-02 1.349 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.565261e-02 1.341 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.771255e-02 1.321 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.808393e-02 1.318 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.859882e-02 1.313 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.859882e-02 1.313 0 0
Regulation of Apoptosis R-HSA-169911 4.867186e-02 1.313 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.911285e-02 1.309 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.946678e-02 1.306 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.144206e-02 1.289 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.144206e-02 1.289 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.144206e-02 1.289 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.174420e-02 1.286 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.188989e-02 1.285 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.239594e-02 1.281 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.239594e-02 1.281 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.410709e-02 1.267 0 0
NRAGE signals death through JNK R-HSA-193648 5.410709e-02 1.267 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.410709e-02 1.267 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.411433e-02 1.267 0 0
Manipulation of host energy metabolism R-HSA-9636667 7.226818e-02 1.141 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 7.226818e-02 1.141 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 7.226818e-02 1.141 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 7.226818e-02 1.141 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 7.226818e-02 1.141 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 7.226818e-02 1.141 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.703708e-02 1.244 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.182537e-02 1.144 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.325478e-02 1.199 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.325478e-02 1.199 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.325478e-02 1.199 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.325478e-02 1.199 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.525542e-02 1.258 0 0
Ephrin signaling R-HSA-3928664 5.525542e-02 1.258 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.602599e-02 1.180 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.726169e-02 1.242 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.974909e-02 1.156 0 0
Signaling by ERBB4 R-HSA-1236394 6.237326e-02 1.205 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.786206e-02 1.168 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.182537e-02 1.144 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.315175e-02 1.200 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.559878e-02 1.255 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.493585e-02 1.188 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.226818e-02 1.141 0 0
Syndecan interactions R-HSA-3000170 6.675532e-02 1.176 0 0
Signaling by NOTCH4 R-HSA-9013694 6.237326e-02 1.205 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.693502e-02 1.245 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.199479e-02 1.143 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.809378e-02 1.236 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.660780e-02 1.176 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.103695e-02 1.214 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.703708e-02 1.244 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.703708e-02 1.244 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.525542e-02 1.258 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.055336e-02 1.218 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.525542e-02 1.258 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.713724e-02 1.173 0 0
Signaling by WNT R-HSA-195721 7.320922e-02 1.135 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.388386e-02 1.131 0 0
Signaling by TGFB family members R-HSA-9006936 7.520739e-02 1.124 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.604524e-02 1.119 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.653418e-02 1.116 0 0
Negative regulation of FLT3 R-HSA-9706369 7.653418e-02 1.116 0 0
TBC/RABGAPs R-HSA-8854214 7.669837e-02 1.115 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.709570e-02 1.113 0 0
Post NMDA receptor activation events R-HSA-438064 7.776765e-02 1.109 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.797571e-02 1.108 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.797571e-02 1.108 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.797571e-02 1.108 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.797571e-02 1.108 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.797571e-02 1.108 0 0
Signal transduction by L1 R-HSA-445144 7.797571e-02 1.108 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.797571e-02 1.108 0 0
Protein hydroxylation R-HSA-9629569 7.797571e-02 1.108 0 0
Modulation by Mtb of host immune system R-HSA-9637628 8.004691e-02 1.097 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.117708e-02 1.091 0 0
Degradation of CDH1 R-HSA-9766229 8.117708e-02 1.091 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.211155e-02 1.086 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.317352e-02 1.080 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.356682e-02 1.078 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.356682e-02 1.078 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 8.475810e-02 1.072 0 0
Interleukin-37 signaling R-HSA-9008059 8.669929e-02 1.062 0 0
Pervasive developmental disorders R-HSA-9005895 8.850833e-02 1.053 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.850833e-02 1.053 0 0
Disorders of Nervous System Development R-HSA-9697154 8.850833e-02 1.053 0 0
Leading Strand Synthesis R-HSA-69109 8.850833e-02 1.053 0 0
Polymerase switching R-HSA-69091 8.850833e-02 1.053 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.850833e-02 1.053 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.850833e-02 1.053 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.850833e-02 1.053 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.850833e-02 1.053 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.850833e-02 1.053 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.850833e-02 1.053 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.850833e-02 1.053 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.967870e-02 1.047 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.967870e-02 1.047 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.968512e-02 1.047 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.052067e-02 1.043 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.126721e-02 1.040 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.126721e-02 1.040 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.126721e-02 1.040 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.324175e-02 1.030 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.398768e-02 1.027 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.398768e-02 1.027 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.466017e-02 1.024 0 0
G1/S Transition R-HSA-69206 9.472525e-02 1.024 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.615237e-02 1.017 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.618071e-02 1.017 0 0
Hedgehog 'off' state R-HSA-5610787 9.909190e-02 1.004 0 0
Glycolysis R-HSA-70171 9.909190e-02 1.004 0 0
Nucleotide Excision Repair R-HSA-5696398 9.967130e-02 1.001 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.982789e-02 1.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.982789e-02 1.001 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.005885e-01 0.997 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.361125e-01 0.866 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.361125e-01 0.866 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.361125e-01 0.866 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.170462e-01 0.932 0 0
Diseases of cellular response to stress R-HSA-9675132 1.170462e-01 0.932 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.141281e-01 0.943 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.141281e-01 0.943 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.141281e-01 0.943 0 0
Calcineurin activates NFAT R-HSA-2025928 1.016242e-01 0.993 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.467231e-01 0.834 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.516218e-01 0.819 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.272533e-01 0.895 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.074195e-01 0.969 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.074195e-01 0.969 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.074195e-01 0.969 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.249372e-01 0.903 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.208025e-01 0.918 0 0
Regulation of signaling by CBL R-HSA-912631 1.437487e-01 0.842 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.437487e-01 0.842 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.170287e-01 0.932 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.376332e-01 0.861 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.106291e-01 0.956 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.106291e-01 0.956 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.045233e-01 0.981 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.045233e-01 0.981 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.045233e-01 0.981 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.083027e-01 0.965 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.083027e-01 0.965 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.184091e-01 0.927 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.047509e-01 0.980 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.047509e-01 0.980 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.069429e-01 0.971 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.087057e-01 0.964 0 0
Neutrophil degranulation R-HSA-6798695 1.239574e-01 0.907 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.468553e-01 0.833 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.340398e-01 0.873 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.340398e-01 0.873 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.340398e-01 0.873 0 0
DNA Damage Bypass R-HSA-73893 1.375961e-01 0.861 0 0
G-protein beta:gamma signalling R-HSA-397795 1.236809e-01 0.908 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.523580e-01 0.817 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.453789e-01 0.837 0 0
Circadian clock R-HSA-9909396 1.479875e-01 0.830 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.236809e-01 0.908 0 0
Metalloprotease DUBs R-HSA-5689901 1.021088e-01 0.991 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.106291e-01 0.956 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.304982e-01 0.884 0 0
Myogenesis R-HSA-525793 1.021088e-01 0.991 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.106291e-01 0.956 0 0
Signaling by RAS mutants R-HSA-6802949 1.045233e-01 0.981 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.070176e-01 0.971 0 0
Mitophagy R-HSA-5205647 1.523580e-01 0.817 0 0
Neurofascin interactions R-HSA-447043 1.467231e-01 0.834 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.467231e-01 0.834 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.523580e-01 0.817 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.313788e-01 0.881 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.313788e-01 0.881 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.313788e-01 0.881 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.313788e-01 0.881 0 0
HCMV Infection R-HSA-9609646 1.022380e-01 0.990 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.376332e-01 0.861 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.157002e-01 0.937 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 1.021088e-01 0.991 0 0
TNF signaling R-HSA-75893 1.518440e-01 0.819 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.272533e-01 0.895 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.208025e-01 0.918 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.296286e-01 0.887 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.272533e-01 0.895 0 0
Degradation of DVL R-HSA-4641258 1.170287e-01 0.932 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.341558e-01 0.872 0 0
Protein methylation R-HSA-8876725 1.490889e-01 0.827 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.255650e-01 0.901 0 0
Signaling by NOTCH R-HSA-157118 1.133872e-01 0.945 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.431190e-01 0.844 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.313788e-01 0.881 0 0
RNA Polymerase II Transcription R-HSA-73857 1.081278e-01 0.966 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.016242e-01 0.993 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.249372e-01 0.903 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.249372e-01 0.903 0 0
Degradation of AXIN R-HSA-4641257 1.170287e-01 0.932 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.170287e-01 0.932 0 0
Death Receptor Signaling R-HSA-73887 1.050381e-01 0.979 0 0
NGF-stimulated transcription R-HSA-9031628 1.259992e-01 0.900 0 0
Suppression of phagosomal maturation R-HSA-9637687 1.021088e-01 0.991 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.130464e-01 0.947 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.429263e-01 0.845 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.208025e-01 0.918 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.456016e-01 0.837 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.272533e-01 0.895 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.341558e-01 0.872 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.053873e-01 0.977 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.158352e-01 0.936 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.375961e-01 0.861 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.375961e-01 0.861 0 0
Inositol phosphate metabolism R-HSA-1483249 1.521327e-01 0.818 0 0
p75NTR signals via NF-kB R-HSA-193639 1.490889e-01 0.827 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.106291e-01 0.956 0 0
MHC class II antigen presentation R-HSA-2132295 1.132129e-01 0.946 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.533091e-01 0.814 0 0
Deadenylation of mRNA R-HSA-429947 1.548414e-01 0.810 0 0
Rab regulation of trafficking R-HSA-9007101 1.595346e-01 0.797 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.601555e-01 0.795 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.624447e-01 0.789 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.624447e-01 0.789 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.624447e-01 0.789 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.624918e-01 0.789 0 0
Glycogen synthesis R-HSA-3322077 1.637674e-01 0.786 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.649590e-01 0.783 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.663317e-01 0.779 0 0
MET interacts with TNS proteins R-HSA-8875513 1.668249e-01 0.778 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.668249e-01 0.778 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.668249e-01 0.778 0 0
Muscle contraction R-HSA-397014 1.675735e-01 0.776 0 0
Translation R-HSA-72766 1.685831e-01 0.773 0 0
Selenoamino acid metabolism R-HSA-2408522 1.700882e-01 0.769 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.715212e-01 0.766 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.715212e-01 0.766 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.715212e-01 0.766 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.715212e-01 0.766 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.733482e-01 0.761 0 0
HDMs demethylate histones R-HSA-3214842 1.733482e-01 0.761 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.733482e-01 0.761 0 0
TGFBR3 expression R-HSA-9839394 1.733482e-01 0.761 0 0
EPH-Ephrin signaling R-HSA-2682334 1.744828e-01 0.758 0 0
Dual incision in TC-NER R-HSA-6782135 1.766163e-01 0.753 0 0
Signaling by NOTCH1 R-HSA-1980143 1.767668e-01 0.753 0 0
Activation of RAC1 R-HSA-428540 1.795174e-01 0.746 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 1.795174e-01 0.746 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.795174e-01 0.746 0 0
NF-kB is activated and signals survival R-HSA-209560 1.795174e-01 0.746 0 0
Budding and maturation of HIV virion R-HSA-162588 1.797325e-01 0.745 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.797325e-01 0.745 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.818720e-01 0.740 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.819031e-01 0.740 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.819031e-01 0.740 0 0
Recycling of eIF2:GDP R-HSA-72731 1.819031e-01 0.740 0 0
CHL1 interactions R-HSA-447041 1.819031e-01 0.740 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.819031e-01 0.740 0 0
FLT3 signaling in disease R-HSA-9682385 1.839878e-01 0.735 0 0
Lagging Strand Synthesis R-HSA-69186 1.848937e-01 0.733 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.848937e-01 0.733 0 0
Basigin interactions R-HSA-210991 1.848937e-01 0.733 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.848937e-01 0.733 0 0
MAP2K and MAPK activation R-HSA-5674135 1.867607e-01 0.729 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.867607e-01 0.729 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.867607e-01 0.729 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.890669e-01 0.723 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.890669e-01 0.723 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.893810e-01 0.723 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.893810e-01 0.723 0 0
Cellular response to hypoxia R-HSA-1234174 1.895614e-01 0.722 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.897000e-01 0.722 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.927534e-01 0.715 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.927534e-01 0.715 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.927534e-01 0.715 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.953282e-01 0.709 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.969535e-01 0.706 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.969535e-01 0.706 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.969535e-01 0.706 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.969535e-01 0.706 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.969535e-01 0.706 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.969535e-01 0.706 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.977316e-01 0.704 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.025832e-01 0.693 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.070179e-01 0.684 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.070179e-01 0.684 0 0
Assembly Of The HIV Virion R-HSA-175474 2.070179e-01 0.684 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.070179e-01 0.684 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.089577e-01 0.680 0 0
Repression of WNT target genes R-HSA-4641265 2.089577e-01 0.680 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.089577e-01 0.680 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.089577e-01 0.680 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.096512e-01 0.679 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.164289e-01 0.665 0 0
Nuclear RNA decay R-HSA-9930044 2.164289e-01 0.665 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.171620e-01 0.663 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.537051e-01 0.596 0 0
Defective GALM causes GALAC4 R-HSA-9931929 2.537051e-01 0.596 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.537051e-01 0.596 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.537051e-01 0.596 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.537051e-01 0.596 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.537051e-01 0.596 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.537051e-01 0.596 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.537051e-01 0.596 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.194147e-01 0.659 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.194147e-01 0.659 0 0
HCN channels R-HSA-1296061 2.194147e-01 0.659 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.194147e-01 0.659 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.194147e-01 0.659 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.194147e-01 0.659 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.194147e-01 0.659 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.194147e-01 0.659 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.552969e-01 0.449 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.552969e-01 0.449 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.552969e-01 0.449 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.552969e-01 0.449 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.552969e-01 0.449 0 0
Defective B4GALT1 causes CDG-2d R-HSA-4793953 3.552969e-01 0.449 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.552969e-01 0.449 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.552969e-01 0.449 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.552969e-01 0.449 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.552969e-01 0.449 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.552969e-01 0.449 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.552969e-01 0.449 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.552969e-01 0.449 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.552969e-01 0.449 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.552969e-01 0.449 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.552969e-01 0.449 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.552969e-01 0.449 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.552969e-01 0.449 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.731290e-01 0.564 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.731290e-01 0.564 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.731290e-01 0.564 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.731290e-01 0.564 0 0
Type I hemidesmosome assembly R-HSA-446107 2.190363e-01 0.659 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.575228e-01 0.589 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 2.575228e-01 0.589 0 0
Lipophagy R-HSA-9613354 2.575228e-01 0.589 0 0
TRAIL signaling R-HSA-75158 3.266880e-01 0.486 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.266880e-01 0.486 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.266880e-01 0.486 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.266880e-01 0.486 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.266880e-01 0.486 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.396416e-01 0.620 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.968105e-01 0.528 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.968105e-01 0.528 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.791391e-01 0.421 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 3.791391e-01 0.421 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.492673e-01 0.603 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.364039e-01 0.473 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.035550e-01 0.518 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.766394e-01 0.558 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.766394e-01 0.558 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.555396e-01 0.593 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.045781e-01 0.516 0 0
Phosphorylation of the APC/C R-HSA-176412 3.362203e-01 0.473 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.362203e-01 0.473 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.758682e-01 0.425 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.758682e-01 0.425 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.758682e-01 0.425 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.758682e-01 0.425 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.297918e-01 0.367 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.297918e-01 0.367 0 0
TRIF-mediated programmed cell death R-HSA-2562578 4.297918e-01 0.367 0 0
SOS-mediated signalling R-HSA-112412 4.297918e-01 0.367 0 0
DAG1 core M1 glycosylations R-HSA-8932506 4.297918e-01 0.367 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.297918e-01 0.367 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.297918e-01 0.367 0 0
RAF activation R-HSA-5673000 2.556563e-01 0.592 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.030777e-01 0.518 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.690105e-01 0.433 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.690105e-01 0.433 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.148299e-01 0.382 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.148299e-01 0.382 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.148299e-01 0.382 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.148299e-01 0.382 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.148299e-01 0.382 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.148299e-01 0.382 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.614500e-01 0.442 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.538878e-01 0.451 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.538878e-01 0.451 0 0
Cristae formation R-HSA-8949613 3.538878e-01 0.451 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.127146e-01 0.505 0 0
FGFR2 alternative splicing R-HSA-6803529 3.900501e-01 0.409 0 0
HIV elongation arrest and recovery R-HSA-167287 3.795562e-01 0.421 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.795562e-01 0.421 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.340524e-01 0.362 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.060812e-01 0.514 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.935627e-01 0.405 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.935627e-01 0.405 0 0
Transcription of the HIV genome R-HSA-167172 4.350197e-01 0.361 0 0
Developmental Cell Lineages R-HSA-9734767 4.222698e-01 0.374 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.265037e-01 0.370 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.339363e-01 0.631 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.555396e-01 0.593 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.934774e-01 0.405 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.308492e-01 0.366 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.547424e-01 0.594 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.465358e-01 0.460 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.016915e-01 0.396 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.968105e-01 0.528 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.226441e-01 0.652 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.283552e-01 0.484 0 0
Regulation of CDH11 function R-HSA-9762292 2.968105e-01 0.528 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.791391e-01 0.421 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.736939e-01 0.563 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.465358e-01 0.460 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.900501e-01 0.409 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.610950e-01 0.442 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.340524e-01 0.362 0 0
Proteasome assembly R-HSA-9907900 2.358220e-01 0.627 0 0
G1 Phase R-HSA-69236 3.528292e-01 0.452 0 0
Cyclin D associated events in G1 R-HSA-69231 3.528292e-01 0.452 0 0
Signaling by NOTCH3 R-HSA-9012852 3.198951e-01 0.495 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.537850e-01 0.596 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 3.329053e-01 0.478 0 0
TCR signaling R-HSA-202403 2.567366e-01 0.591 0 0
UCH proteinases R-HSA-5689603 2.543905e-01 0.594 0 0
ER-Phagosome pathway R-HSA-1236974 2.735685e-01 0.563 0 0
Long-term potentiation R-HSA-9620244 3.030777e-01 0.518 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.709001e-01 0.567 0 0
Opioid Signalling R-HSA-111885 3.288743e-01 0.483 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.699623e-01 0.432 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.873740e-01 0.542 0 0
Adrenoceptors R-HSA-390696 2.190363e-01 0.659 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.297918e-01 0.367 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.016915e-01 0.396 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.465358e-01 0.460 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.308492e-01 0.366 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.760474e-01 0.559 0 0
Neurexins and neuroligins R-HSA-6794361 2.678284e-01 0.572 0 0
Frs2-mediated activation R-HSA-170968 2.396416e-01 0.620 0 0
Signaling by FGFR2 R-HSA-5654738 4.131906e-01 0.384 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.521115e-01 0.453 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.538878e-01 0.451 0 0
Signaling by Hedgehog R-HSA-5358351 3.395206e-01 0.469 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.180857e-01 0.661 0 0
Signaling by NOTCH2 R-HSA-1980145 2.556563e-01 0.592 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.309230e-01 0.637 0 0
Signaling by FGFR4 R-HSA-5654743 3.326650e-01 0.478 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.035550e-01 0.518 0 0
DAG and IP3 signaling R-HSA-1489509 2.531537e-01 0.597 0 0
Hedgehog 'on' state R-HSA-5632684 2.724632e-01 0.565 0 0
Calmodulin induced events R-HSA-111933 2.968604e-01 0.527 0 0
Signaling by FGFR3 R-HSA-5654741 3.731479e-01 0.428 0 0
MAPK family signaling cascades R-HSA-5683057 3.936937e-01 0.405 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.934774e-01 0.405 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.283552e-01 0.484 0 0
CaM pathway R-HSA-111997 2.968604e-01 0.527 0 0
Developmental Biology R-HSA-1266738 2.930875e-01 0.533 0 0
Prolonged ERK activation events R-HSA-169893 3.362203e-01 0.473 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.555396e-01 0.593 0 0
PI Metabolism R-HSA-1483255 2.261156e-01 0.646 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.537051e-01 0.596 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.552969e-01 0.449 0 0
Proton/oligopeptide cotransporters R-HSA-427975 3.266880e-01 0.486 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.492673e-01 0.603 0 0
Bicarbonate transporters R-HSA-425381 3.364039e-01 0.473 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.339363e-01 0.631 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.329053e-01 0.478 0 0
Signaling by LTK R-HSA-9842663 4.148299e-01 0.382 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 4.016915e-01 0.396 0 0
MAP kinase activation R-HSA-450294 4.289021e-01 0.368 0 0
Regulated Necrosis R-HSA-5218859 4.350197e-01 0.361 0 0
Signaling by VEGF R-HSA-194138 2.451580e-01 0.611 0 0
RSV-host interactions R-HSA-9833110 3.421359e-01 0.466 0 0
HCMV Late Events R-HSA-9610379 2.752000e-01 0.560 0 0
Generic Transcription Pathway R-HSA-212436 3.268507e-01 0.486 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.290395e-01 0.640 0 0
Gap junction trafficking and regulation R-HSA-157858 2.188708e-01 0.660 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.902136e-01 0.409 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.709001e-01 0.567 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.416696e-01 0.466 0 0
Glycogen metabolism R-HSA-8982491 3.828615e-01 0.417 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.962105e-01 0.402 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.465358e-01 0.460 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.344546e-01 0.362 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.731290e-01 0.564 0 0
Glycogen storage diseases R-HSA-3229121 2.226441e-01 0.652 0 0
Nef and signal transduction R-HSA-164944 3.791391e-01 0.421 0 0
Gap junction trafficking R-HSA-190828 2.358220e-01 0.627 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.016915e-01 0.396 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.735389e-01 0.428 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.937869e-01 0.405 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.678284e-01 0.572 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.727962e-01 0.564 0 0
Other interleukin signaling R-HSA-449836 2.766394e-01 0.558 0 0
Viral Infection Pathways R-HSA-9824446 2.210918e-01 0.655 0 0
Inhibition of membrane repair R-HSA-9635644 3.552969e-01 0.449 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.266880e-01 0.486 0 0
Maturation of nucleoprotein R-HSA-9683610 2.396416e-01 0.620 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.791391e-01 0.421 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.537850e-01 0.596 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 4.297918e-01 0.367 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.148299e-01 0.382 0 0
PCP/CE pathway R-HSA-4086400 3.810371e-01 0.419 0 0
FLT3 Signaling R-HSA-9607240 4.046870e-01 0.393 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.127146e-01 0.505 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.329053e-01 0.478 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.937759e-01 0.405 0 0
Signaling by TGFBR3 R-HSA-9839373 3.935627e-01 0.405 0 0
Glucose metabolism R-HSA-70326 2.870466e-01 0.542 0 0
Cellular response to chemical stress R-HSA-9711123 4.068243e-01 0.391 0 0
Maturation of nucleoprotein R-HSA-9694631 2.766394e-01 0.558 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.297918e-01 0.367 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.358220e-01 0.627 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.610950e-01 0.442 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.329053e-01 0.478 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.297918e-01 0.367 0 0
Gap junction assembly R-HSA-190861 2.556563e-01 0.592 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.005136e-01 0.522 0 0
Nephrin family interactions R-HSA-373753 3.045781e-01 0.516 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.580193e-01 0.588 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.531537e-01 0.597 0 0
Metallothioneins bind metals R-HSA-5661231 4.148299e-01 0.382 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.833787e-01 0.416 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.873740e-01 0.542 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.035550e-01 0.518 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.690105e-01 0.433 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.569587e-01 0.447 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.308492e-01 0.366 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.575174e-01 0.447 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.348963e-01 0.629 0 0
IRE1alpha activates chaperones R-HSA-381070 2.319700e-01 0.635 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.301997e-01 0.366 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.185541e-01 0.378 0 0
Regulation of BACH1 activity R-HSA-9708530 3.362203e-01 0.473 0 0
Translation of Structural Proteins R-HSA-9683701 4.265037e-01 0.370 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.404334e-01 0.356 0 0
RNA Polymerase III Transcription R-HSA-74158 4.404334e-01 0.356 0 0
RUNX2 regulates bone development R-HSA-8941326 4.404334e-01 0.356 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.430642e-01 0.354 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 4.430642e-01 0.354 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.430642e-01 0.354 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.430642e-01 0.354 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 4.430642e-01 0.354 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.430642e-01 0.354 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.430642e-01 0.354 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.430642e-01 0.354 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 4.430642e-01 0.354 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.430642e-01 0.354 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.430642e-01 0.354 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.430642e-01 0.354 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.430642e-01 0.354 0 0
Defective ABCD1 causes ALD R-HSA-5684045 4.430642e-01 0.354 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.430642e-01 0.354 0 0
Potassium transport channels R-HSA-1296067 4.430642e-01 0.354 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.430642e-01 0.354 0 0
C6 deamination of adenosine R-HSA-75102 4.430642e-01 0.354 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.430642e-01 0.354 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.430642e-01 0.354 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.468226e-01 0.350 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.468226e-01 0.350 0 0
Heme signaling R-HSA-9707616 4.472196e-01 0.349 0 0
Ca-dependent events R-HSA-111996 4.482466e-01 0.348 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.529754e-01 0.344 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.529754e-01 0.344 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.529754e-01 0.344 0 0
Trafficking of AMPA receptors R-HSA-399719 4.562648e-01 0.341 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.562648e-01 0.341 0 0
ABC-family proteins mediated transport R-HSA-382556 4.579378e-01 0.339 0 0
Signaling by FGFR1 R-HSA-5654736 4.604939e-01 0.337 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.648436e-01 0.333 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.659064e-01 0.332 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.659064e-01 0.332 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.659064e-01 0.332 0 0
Regulation by c-FLIP R-HSA-3371378 4.781639e-01 0.320 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.781639e-01 0.320 0 0
DAG1 core M2 glycosylations R-HSA-8932504 4.781639e-01 0.320 0 0
Dimerization of procaspase-8 R-HSA-69416 4.781639e-01 0.320 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.781639e-01 0.320 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.781639e-01 0.320 0 0
Formation of annular gap junctions R-HSA-196025 4.781639e-01 0.320 0 0
MET receptor recycling R-HSA-8875656 4.781639e-01 0.320 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.781639e-01 0.320 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.781639e-01 0.320 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.781639e-01 0.320 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.781639e-01 0.320 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.781639e-01 0.320 0 0
Sodium/Proton exchangers R-HSA-425986 4.781639e-01 0.320 0 0
Downstream TCR signaling R-HSA-202424 4.809319e-01 0.318 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.813127e-01 0.318 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.813995e-01 0.317 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.813995e-01 0.317 0 0
MET promotes cell motility R-HSA-8875878 4.867670e-01 0.313 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.867670e-01 0.313 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.900474e-01 0.310 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.900474e-01 0.310 0 0
Malate-aspartate shuttle R-HSA-9856872 4.900474e-01 0.310 0 0
Physiological factors R-HSA-5578768 4.900474e-01 0.310 0 0
Signal regulatory protein family interactions R-HSA-391160 4.900474e-01 0.310 0 0
Regulation of KIT signaling R-HSA-1433559 4.900474e-01 0.310 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.935354e-01 0.307 0 0
tRNA processing R-HSA-72306 4.991425e-01 0.302 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.061678e-01 0.296 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.061678e-01 0.296 0 0
Cardiogenesis R-HSA-9733709 5.061678e-01 0.296 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.061678e-01 0.296 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.093924e-01 0.293 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.095229e-01 0.293 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.095229e-01 0.293 0 0
Extension of Telomeres R-HSA-180786 5.173619e-01 0.286 0 0
Axonal growth stimulation R-HSA-209563 5.188876e-01 0.285 0 0
MET activates PTPN11 R-HSA-8865999 5.188876e-01 0.285 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.188876e-01 0.285 0 0
Defective gamma-carboxylation of F9 R-HSA-9673240 5.188876e-01 0.285 0 0
Histamine receptors R-HSA-390650 5.188876e-01 0.285 0 0
FasL/ CD95L signaling R-HSA-75157 5.188876e-01 0.285 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.194179e-01 0.284 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.233681e-01 0.281 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.239377e-01 0.281 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.239377e-01 0.281 0 0
Gap junction degradation R-HSA-190873 5.239377e-01 0.281 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.239377e-01 0.281 0 0
CASP8 activity is inhibited R-HSA-5218900 5.239377e-01 0.281 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 5.239377e-01 0.281 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.239377e-01 0.281 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.239377e-01 0.281 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.239377e-01 0.281 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.239377e-01 0.281 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.239377e-01 0.281 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.258408e-01 0.279 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.258408e-01 0.279 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.258408e-01 0.279 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.258408e-01 0.279 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.258408e-01 0.279 0 0
G-protein activation R-HSA-202040 5.274683e-01 0.278 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 5.274683e-01 0.278 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.290105e-01 0.277 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.290105e-01 0.277 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.304927e-01 0.275 0 0
HIV Transcription Elongation R-HSA-167169 5.319211e-01 0.274 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.319211e-01 0.274 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.319211e-01 0.274 0 0
Generation of second messenger molecules R-HSA-202433 5.319211e-01 0.274 0 0
G-protein mediated events R-HSA-112040 5.371693e-01 0.270 0 0
Pyruvate metabolism R-HSA-70268 5.407060e-01 0.267 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.538216e-01 0.257 0 0
PLC beta mediated events R-HSA-112043 5.542217e-01 0.256 0 0
Signal amplification R-HSA-392518 5.543054e-01 0.256 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.551985e-01 0.256 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.551985e-01 0.256 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.551985e-01 0.256 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.569220e-01 0.254 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.601976e-01 0.252 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.601976e-01 0.252 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.601976e-01 0.252 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.601976e-01 0.252 0 0
Cilium Assembly R-HSA-5617833 5.665508e-01 0.247 0 0
Binding and entry of HIV virion R-HSA-173107 5.669242e-01 0.246 0 0
PI3K/AKT activation R-HSA-198203 5.669242e-01 0.246 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.669242e-01 0.246 0 0
DNA replication initiation R-HSA-68952 5.669242e-01 0.246 0 0
Signal attenuation R-HSA-74749 5.669242e-01 0.246 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.669242e-01 0.246 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.669242e-01 0.246 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.669242e-01 0.246 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 5.669242e-01 0.246 0 0
G alpha (z) signalling events R-HSA-418597 5.729342e-01 0.242 0 0
GPER1 signaling R-HSA-9634597 5.739568e-01 0.241 0 0
PERK regulates gene expression R-HSA-381042 5.775456e-01 0.238 0 0
DARPP-32 events R-HSA-180024 5.806472e-01 0.236 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.843919e-01 0.233 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.843919e-01 0.233 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.843919e-01 0.233 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 5.843919e-01 0.233 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.843919e-01 0.233 0 0
Regulation of gap junction activity R-HSA-191650 5.843919e-01 0.233 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.843919e-01 0.233 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.843919e-01 0.233 0 0
Dopamine receptors R-HSA-390651 5.843919e-01 0.233 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.853581e-01 0.233 0 0
Notch-HLH transcription pathway R-HSA-350054 5.853581e-01 0.233 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.853581e-01 0.233 0 0
Stimuli-sensing channels R-HSA-2672351 5.854125e-01 0.233 0 0
Interleukin-17 signaling R-HSA-448424 5.886715e-01 0.230 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.930018e-01 0.227 0 0
Galactose catabolism R-HSA-70370 5.930018e-01 0.227 0 0
Response to metal ions R-HSA-5660526 5.930018e-01 0.227 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.964420e-01 0.224 0 0
Interleukin-1 family signaling R-HSA-446652 5.971002e-01 0.224 0 0
ABC transporter disorders R-HSA-5619084 6.036171e-01 0.219 0 0
PECAM1 interactions R-HSA-210990 6.070338e-01 0.217 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.070338e-01 0.217 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.070338e-01 0.217 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.070338e-01 0.217 0 0
LGI-ADAM interactions R-HSA-5682910 6.070338e-01 0.217 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.070338e-01 0.217 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 6.070338e-01 0.217 0 0
Signaling by APC mutants R-HSA-4839744 6.070338e-01 0.217 0 0
Protein localization R-HSA-9609507 6.083729e-01 0.216 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.099913e-01 0.215 0 0
Signaling by Interleukins R-HSA-449147 6.186625e-01 0.209 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.241743e-01 0.205 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.241743e-01 0.205 0 0
Specification of primordial germ cells R-HSA-9827857 6.241743e-01 0.205 0 0
Signaling by FGFR R-HSA-190236 6.282012e-01 0.202 0 0
Signaling by NTRKs R-HSA-166520 6.312566e-01 0.200 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.321188e-01 0.199 0 0
Netrin-1 signaling R-HSA-373752 6.368005e-01 0.196 0 0
RMTs methylate histone arginines R-HSA-3214858 6.368005e-01 0.196 0 0
Ca2+ pathway R-HSA-4086398 6.374554e-01 0.196 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.389008e-01 0.195 0 0
Complex III assembly R-HSA-9865881 6.389008e-01 0.195 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.389008e-01 0.195 0 0
Co-inhibition by BTLA R-HSA-9927353 6.409809e-01 0.193 0 0
IRS activation R-HSA-74713 6.409809e-01 0.193 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.409809e-01 0.193 0 0
G2 Phase R-HSA-68911 6.409809e-01 0.193 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.409809e-01 0.193 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.409809e-01 0.193 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.409809e-01 0.193 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.409809e-01 0.193 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 6.409809e-01 0.193 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.409809e-01 0.193 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.409809e-01 0.193 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.409809e-01 0.193 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.409809e-01 0.193 0 0
PTK6 Down-Regulation R-HSA-8849472 6.409809e-01 0.193 0 0
Activation of C3 and C5 R-HSA-174577 6.409809e-01 0.193 0 0
Reelin signalling pathway R-HSA-8866376 6.409809e-01 0.193 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.409809e-01 0.193 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.409809e-01 0.193 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.409809e-01 0.193 0 0
NrCAM interactions R-HSA-447038 6.409809e-01 0.193 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.409809e-01 0.193 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.433479e-01 0.192 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.442531e-01 0.191 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.442531e-01 0.191 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 6.442531e-01 0.191 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.442531e-01 0.191 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 6.442531e-01 0.191 0 0
Signaling by AXIN mutants R-HSA-4839735 6.442531e-01 0.191 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.442531e-01 0.191 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.442531e-01 0.191 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.442531e-01 0.191 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.502214e-01 0.187 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.504538e-01 0.187 0 0
Signaling by WNT in cancer R-HSA-4791275 6.519922e-01 0.186 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.519922e-01 0.186 0 0
GAB1 signalosome R-HSA-180292 6.536680e-01 0.185 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.536680e-01 0.185 0 0
Polo-like kinase mediated events R-HSA-156711 6.536680e-01 0.185 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.536680e-01 0.185 0 0
Apoptotic factor-mediated response R-HSA-111471 6.536680e-01 0.185 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.560843e-01 0.183 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.560843e-01 0.183 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.560843e-01 0.183 0 0
Somitogenesis R-HSA-9824272 6.560843e-01 0.183 0 0
SARS-CoV Infections R-HSA-9679506 6.570188e-01 0.182 0 0
RAB geranylgeranylation R-HSA-8873719 6.618725e-01 0.179 0 0
Signaling by ALK R-HSA-201556 6.638535e-01 0.178 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.638535e-01 0.178 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.639134e-01 0.178 0 0
G protein gated Potassium channels R-HSA-1296059 6.639134e-01 0.178 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.639134e-01 0.178 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.639134e-01 0.178 0 0
Tight junction interactions R-HSA-420029 6.639134e-01 0.178 0 0
Iron uptake and transport R-HSA-917937 6.682072e-01 0.175 0 0
Interleukin-1 signaling R-HSA-9020702 6.682590e-01 0.175 0 0
Integrin signaling R-HSA-354192 6.739739e-01 0.171 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.786255e-01 0.168 0 0
Maple Syrup Urine Disease R-HSA-9865114 6.786255e-01 0.168 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.786255e-01 0.168 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.786255e-01 0.168 0 0
Regulation of IFNG signaling R-HSA-877312 6.786255e-01 0.168 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.786255e-01 0.168 0 0
Interleukin-15 signaling R-HSA-8983432 6.786255e-01 0.168 0 0
OAS antiviral response R-HSA-8983711 6.786255e-01 0.168 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.814628e-01 0.167 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.814628e-01 0.167 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.814628e-01 0.167 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.814628e-01 0.167 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.836017e-01 0.165 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.836017e-01 0.165 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.836017e-01 0.165 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.877172e-01 0.163 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.898676e-01 0.161 0 0
Plus-strand DNA synthesis R-HSA-164525 6.898676e-01 0.161 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.898676e-01 0.161 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.898676e-01 0.161 0 0
PDE3B signalling R-HSA-165160 6.898676e-01 0.161 0 0
PKB-mediated events R-HSA-109703 6.898676e-01 0.161 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 6.898676e-01 0.161 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 6.898676e-01 0.161 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.898676e-01 0.161 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.898676e-01 0.161 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.898676e-01 0.161 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.898676e-01 0.161 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.898676e-01 0.161 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.898676e-01 0.161 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.898676e-01 0.161 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.898676e-01 0.161 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.898676e-01 0.161 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.898676e-01 0.161 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.898676e-01 0.161 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.898676e-01 0.161 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.898676e-01 0.161 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.898676e-01 0.161 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.898676e-01 0.161 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.898676e-01 0.161 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.927488e-01 0.159 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.927488e-01 0.159 0 0
Mitochondrial protein import R-HSA-1268020 6.942368e-01 0.158 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.950142e-01 0.158 0 0
Interferon alpha/beta signaling R-HSA-909733 6.990287e-01 0.156 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.075614e-01 0.150 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.075614e-01 0.150 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.075614e-01 0.150 0 0
Signaling by NODAL R-HSA-1181150 7.075614e-01 0.150 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.075614e-01 0.150 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.096696e-01 0.149 0 0
Intraflagellar transport R-HSA-5620924 7.100993e-01 0.149 0 0
Co-stimulation by CD28 R-HSA-389356 7.100993e-01 0.149 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.102360e-01 0.149 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.102360e-01 0.149 0 0
Interleukin-6 signaling R-HSA-1059683 7.102360e-01 0.149 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.102360e-01 0.149 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.102360e-01 0.149 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.102360e-01 0.149 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.103019e-01 0.149 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.103019e-01 0.149 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.103019e-01 0.149 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.103019e-01 0.149 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.151017e-01 0.146 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.207667e-01 0.142 0 0
HIV Transcription Initiation R-HSA-167161 7.207667e-01 0.142 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.207667e-01 0.142 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.207667e-01 0.142 0 0
Integration of energy metabolism R-HSA-163685 7.226601e-01 0.141 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.245907e-01 0.140 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.321000e-01 0.135 0 0
Signaling by LTK in cancer R-HSA-9842640 7.321000e-01 0.135 0 0
Chylomicron clearance R-HSA-8964026 7.321000e-01 0.135 0 0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656244 7.321000e-01 0.135 0 0
STAT5 Activation R-HSA-9645135 7.321000e-01 0.135 0 0
Uncoating of the HIV Virion R-HSA-162585 7.321000e-01 0.135 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 7.321000e-01 0.135 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.321000e-01 0.135 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.321000e-01 0.135 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 7.321000e-01 0.135 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.321000e-01 0.135 0 0
Lactose synthesis R-HSA-5653890 7.321000e-01 0.135 0 0
CREB phosphorylation R-HSA-199920 7.321000e-01 0.135 0 0
Agmatine biosynthesis R-HSA-351143 7.321000e-01 0.135 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.321000e-01 0.135 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 7.321000e-01 0.135 0 0
Metabolism of vitamin K R-HSA-6806664 7.321000e-01 0.135 0 0
Leukotriene receptors R-HSA-391906 7.321000e-01 0.135 0 0
Signalling to ERKs R-HSA-187687 7.342328e-01 0.134 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.364252e-01 0.133 0 0
Activation of GABAB receptors R-HSA-991365 7.381686e-01 0.132 0 0
GABA B receptor activation R-HSA-977444 7.381686e-01 0.132 0 0
Removal of the Flap Intermediate R-HSA-69166 7.391995e-01 0.131 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.391995e-01 0.131 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.391995e-01 0.131 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 7.391995e-01 0.131 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 7.391995e-01 0.131 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 7.391995e-01 0.131 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.391995e-01 0.131 0 0
Zinc transporters R-HSA-435354 7.391995e-01 0.131 0 0
Transmission across Chemical Synapses R-HSA-112315 7.439880e-01 0.128 0 0
mRNA Capping R-HSA-72086 7.518297e-01 0.124 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.518297e-01 0.124 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.518297e-01 0.124 0 0
Signaling by Erythropoietin R-HSA-9006335 7.518297e-01 0.124 0 0
Platelet calcium homeostasis R-HSA-418360 7.518297e-01 0.124 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.518297e-01 0.124 0 0
Glucagon-type ligand receptors R-HSA-420092 7.518297e-01 0.124 0 0
RET signaling R-HSA-8853659 7.524103e-01 0.124 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.547723e-01 0.122 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.547723e-01 0.122 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.547819e-01 0.122 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.566884e-01 0.121 0 0
Peroxisomal protein import R-HSA-9033241 7.620311e-01 0.118 0 0
Erythropoietin activates RAS R-HSA-9027284 7.656506e-01 0.116 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.656506e-01 0.116 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.656506e-01 0.116 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.656506e-01 0.116 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 7.656506e-01 0.116 0 0
DCC mediated attractive signaling R-HSA-418885 7.656506e-01 0.116 0 0
Signaling by Activin R-HSA-1502540 7.656506e-01 0.116 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.656506e-01 0.116 0 0
Biotin transport and metabolism R-HSA-196780 7.656506e-01 0.116 0 0
Other semaphorin interactions R-HSA-416700 7.656506e-01 0.116 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.679920e-01 0.115 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.679920e-01 0.115 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.685834e-01 0.114 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.685834e-01 0.114 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.685834e-01 0.114 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.685834e-01 0.114 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.685834e-01 0.114 0 0
Disinhibition of SNARE formation R-HSA-114516 7.685834e-01 0.114 0 0
PTK6 Expression R-HSA-8849473 7.685834e-01 0.114 0 0
Cysteine formation from homocysteine R-HSA-1614603 7.685834e-01 0.114 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.685834e-01 0.114 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.685834e-01 0.114 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.685834e-01 0.114 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.685834e-01 0.114 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.685834e-01 0.114 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.685834e-01 0.114 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.685834e-01 0.114 0 0
Amine ligand-binding receptors R-HSA-375280 7.706111e-01 0.113 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.708042e-01 0.113 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.708802e-01 0.113 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.727987e-01 0.112 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.750540e-01 0.111 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.750540e-01 0.111 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.759704e-01 0.110 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.759704e-01 0.110 0 0
Neurotransmitter release cycle R-HSA-112310 7.795124e-01 0.108 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.826646e-01 0.106 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.856647e-01 0.105 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.856647e-01 0.105 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.886197e-01 0.103 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.888196e-01 0.103 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.897362e-01 0.103 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.897362e-01 0.103 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.897362e-01 0.103 0 0
Activation of SMO R-HSA-5635838 7.897362e-01 0.103 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.897362e-01 0.103 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.897362e-01 0.103 0 0
Potential therapeutics for SARS R-HSA-9679191 7.931214e-01 0.101 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.956385e-01 0.099 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.956385e-01 0.099 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.956385e-01 0.099 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.956385e-01 0.099 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.956385e-01 0.099 0 0
Growth hormone receptor signaling R-HSA-982772 7.956385e-01 0.099 0 0
Reverse Transcription of HIV RNA R-HSA-162589 8.001003e-01 0.097 0 0
Minus-strand DNA synthesis R-HSA-164516 8.001003e-01 0.097 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.001003e-01 0.097 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.001003e-01 0.097 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.001003e-01 0.097 0 0
Interleukin-23 signaling R-HSA-9020933 8.001003e-01 0.097 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 8.001003e-01 0.097 0 0
Fructose biosynthesis R-HSA-5652227 8.001003e-01 0.097 0 0
FGFR1b ligand binding and activation R-HSA-190370 8.001003e-01 0.097 0 0
Co-stimulation by ICOS R-HSA-9927354 8.001003e-01 0.097 0 0
TGFBR3 PTM regulation R-HSA-9839383 8.001003e-01 0.097 0 0
SLC-mediated bile acid transport R-HSA-9958517 8.001003e-01 0.097 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.001003e-01 0.097 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.001003e-01 0.097 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.013392e-01 0.096 0 0
Regulation of insulin secretion R-HSA-422356 8.042876e-01 0.095 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.042876e-01 0.095 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.042876e-01 0.095 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.042876e-01 0.095 0 0
Adipogenesis R-HSA-9843745 8.051521e-01 0.094 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.059543e-01 0.094 0 0
Fibronectin matrix formation R-HSA-1566977 8.116101e-01 0.091 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 8.116101e-01 0.091 0 0
Heme assimilation R-HSA-9927020 8.116101e-01 0.091 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.116101e-01 0.091 0 0
Coenzyme A biosynthesis R-HSA-196783 8.116101e-01 0.091 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.116101e-01 0.091 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.138419e-01 0.089 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.141437e-01 0.089 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.145145e-01 0.089 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.162423e-01 0.088 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.209102e-01 0.086 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.215823e-01 0.085 0 0
Ion homeostasis R-HSA-5578775 8.249102e-01 0.084 0 0
Platelet degranulation R-HSA-114608 8.262975e-01 0.083 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.273264e-01 0.082 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.273264e-01 0.082 0 0
Interaction With Cumulus Cells And The Zona Pellucida R-HSA-2534343 8.273264e-01 0.082 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.273264e-01 0.082 0 0
mRNA Editing R-HSA-75072 8.273264e-01 0.082 0 0
ARMS-mediated activation R-HSA-170984 8.273264e-01 0.082 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.273264e-01 0.082 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.273264e-01 0.082 0 0
WNT mediated activation of DVL R-HSA-201688 8.273264e-01 0.082 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 8.273264e-01 0.082 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.273264e-01 0.082 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.273264e-01 0.082 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.273264e-01 0.082 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.273264e-01 0.082 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.273264e-01 0.082 0 0
Laminin interactions R-HSA-3000157 8.306508e-01 0.081 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.306508e-01 0.081 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.306508e-01 0.081 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.306508e-01 0.081 0 0
Interleukin-7 signaling R-HSA-1266695 8.306508e-01 0.081 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.314278e-01 0.080 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.314278e-01 0.080 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.314278e-01 0.080 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.344025e-01 0.079 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.354643e-01 0.078 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.363560e-01 0.078 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.384039e-01 0.077 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.389756e-01 0.076 0 0
Intra-Golgi traffic R-HSA-6811438 8.422924e-01 0.075 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.422924e-01 0.075 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.426387e-01 0.074 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.445105e-01 0.073 0 0
Signaling by FGFR in disease R-HSA-1226099 8.454618e-01 0.073 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.461385e-01 0.073 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.461385e-01 0.073 0 0
MET activates PTK2 signaling R-HSA-8874081 8.461385e-01 0.073 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.490153e-01 0.071 0 0
PKA activation R-HSA-163615 8.493434e-01 0.071 0 0
PKA activation in glucagon signalling R-HSA-164378 8.493434e-01 0.071 0 0
Platelet sensitization by LDL R-HSA-432142 8.493434e-01 0.071 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.493434e-01 0.071 0 0
Mismatch Repair R-HSA-5358508 8.493434e-01 0.071 0 0
Nephron development R-HSA-9831926 8.493434e-01 0.071 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.493434e-01 0.071 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.493434e-01 0.071 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.508457e-01 0.070 0 0
Interleukin-27 signaling R-HSA-9020956 8.508457e-01 0.070 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.508457e-01 0.070 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.508457e-01 0.070 0 0
Formation of apoptosome R-HSA-111458 8.508457e-01 0.070 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.508457e-01 0.070 0 0
Signaling by Leptin R-HSA-2586552 8.508457e-01 0.070 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.548243e-01 0.068 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.558086e-01 0.068 0 0
Regulation of beta-cell development R-HSA-186712 8.574550e-01 0.067 0 0
Mitochondrial biogenesis R-HSA-1592230 8.596431e-01 0.066 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.603799e-01 0.065 0 0
Insulin processing R-HSA-264876 8.603799e-01 0.065 0 0
SLC transporter disorders R-HSA-5619102 8.606778e-01 0.065 0 0
Neuronal System R-HSA-112316 8.621605e-01 0.064 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.623755e-01 0.064 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.655075e-01 0.063 0 0
HDL remodeling R-HSA-8964058 8.655075e-01 0.063 0 0
The NLRP3 inflammasome R-HSA-844456 8.655075e-01 0.063 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.655075e-01 0.063 0 0
Diseases of hemostasis R-HSA-9671793 8.655075e-01 0.063 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.655075e-01 0.063 0 0
Signaling by SCF-KIT R-HSA-1433557 8.655288e-01 0.063 0 0
Metabolism of polyamines R-HSA-351202 8.671441e-01 0.062 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.711627e-01 0.060 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.711627e-01 0.060 0 0
vRNP Assembly R-HSA-192905 8.711627e-01 0.060 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.711627e-01 0.060 0 0
Synthesis of PI R-HSA-1483226 8.711627e-01 0.060 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.711627e-01 0.060 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.711627e-01 0.060 0 0
Chylomicron assembly R-HSA-8963888 8.711627e-01 0.060 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.711627e-01 0.060 0 0
Suppression of apoptosis R-HSA-9635465 8.711627e-01 0.060 0 0
Prostanoid ligand receptors R-HSA-391908 8.711627e-01 0.060 0 0
Transport of RCbl within the body R-HSA-9758890 8.711627e-01 0.060 0 0
Interleukin-2 signaling R-HSA-9020558 8.711627e-01 0.060 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.711627e-01 0.060 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.712325e-01 0.060 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.717239e-01 0.060 0 0
Translation of Structural Proteins R-HSA-9694635 8.721890e-01 0.059 0 0
Triglyceride catabolism R-HSA-163560 8.732933e-01 0.059 0 0
GPVI-mediated activation cascade R-HSA-114604 8.732933e-01 0.059 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.734505e-01 0.059 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.734505e-01 0.059 0 0
Aquaporin-mediated transport R-HSA-445717 8.762849e-01 0.057 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.782915e-01 0.056 0 0
FOXO-mediated transcription R-HSA-9614085 8.784358e-01 0.056 0 0
Pregnenolone biosynthesis R-HSA-196108 8.800647e-01 0.055 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.800647e-01 0.055 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.805529e-01 0.055 0 0
COPII-mediated vesicle transport R-HSA-204005 8.820729e-01 0.054 0 0
Gamma-carboxylation of protein precursors R-HSA-159740 8.887132e-01 0.051 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.887132e-01 0.051 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.887132e-01 0.051 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.887132e-01 0.051 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.887132e-01 0.051 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.887132e-01 0.051 0 0
Anchoring fibril formation R-HSA-2214320 8.887132e-01 0.051 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.887132e-01 0.051 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.887132e-01 0.051 0 0
Mitochondrial protein degradation R-HSA-9837999 8.924275e-01 0.049 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.931527e-01 0.049 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.931527e-01 0.049 0 0
Elastic fibre formation R-HSA-1566948 8.941222e-01 0.049 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.963767e-01 0.048 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.963767e-01 0.048 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.018479e-01 0.045 0 0
RAS processing R-HSA-9648002 9.033619e-01 0.044 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.035164e-01 0.044 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.035164e-01 0.044 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 9.038739e-01 0.044 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 9.038739e-01 0.044 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.038739e-01 0.044 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 9.038739e-01 0.044 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 9.038739e-01 0.044 0 0
MET activates RAS signaling R-HSA-8851805 9.038739e-01 0.044 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.038739e-01 0.044 0 0
Conjugation of salicylate with glycine R-HSA-177128 9.038739e-01 0.044 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.038739e-01 0.044 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 9.038739e-01 0.044 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 9.038739e-01 0.044 0 0
Interleukin-35 Signalling R-HSA-8984722 9.038739e-01 0.044 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.038739e-01 0.044 0 0
Attachment and Entry R-HSA-9694614 9.049017e-01 0.043 0 0
Signaling by PDGFR in disease R-HSA-9671555 9.049017e-01 0.043 0 0
Ribavirin ADME R-HSA-9755088 9.049017e-01 0.043 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.049017e-01 0.043 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.049017e-01 0.043 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.051247e-01 0.043 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.051247e-01 0.043 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.063771e-01 0.043 0 0
Cargo concentration in the ER R-HSA-5694530 9.063771e-01 0.043 0 0
Downstream signal transduction R-HSA-186763 9.063771e-01 0.043 0 0
Potassium Channels R-HSA-1296071 9.107828e-01 0.041 0 0
Metal ion SLC transporters R-HSA-425410 9.112890e-01 0.040 0 0
Interleukin-2 family signaling R-HSA-451927 9.118806e-01 0.040 0 0
Fructose metabolism R-HSA-5652084 9.154334e-01 0.038 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.154334e-01 0.038 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.154334e-01 0.038 0 0
G0 and Early G1 R-HSA-1538133 9.154949e-01 0.038 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.169699e-01 0.038 0 0
Chylomicron remodeling R-HSA-8963901 9.169699e-01 0.038 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.169699e-01 0.038 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.169699e-01 0.038 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 9.169699e-01 0.038 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 9.169699e-01 0.038 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.169699e-01 0.038 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 9.169699e-01 0.038 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.169699e-01 0.038 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.169699e-01 0.038 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 9.169699e-01 0.038 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.169699e-01 0.038 0 0
Adaptive Immune System R-HSA-1280218 9.173297e-01 0.037 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.191707e-01 0.037 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.221952e-01 0.035 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.237963e-01 0.034 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.248614e-01 0.034 0 0
Interleukin-20 family signaling R-HSA-8854691 9.248614e-01 0.034 0 0
Formation of the ureteric bud R-HSA-9830674 9.248614e-01 0.034 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.248614e-01 0.034 0 0
Platelet homeostasis R-HSA-418346 9.250416e-01 0.034 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.253688e-01 0.034 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.255763e-01 0.034 0 0
Gastrulation R-HSA-9758941 9.264767e-01 0.033 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.282539e-01 0.032 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 9.282824e-01 0.032 0 0
cGMP effects R-HSA-418457 9.282824e-01 0.032 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.282824e-01 0.032 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.282824e-01 0.032 0 0
P2Y receptors R-HSA-417957 9.282824e-01 0.032 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.282824e-01 0.032 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.284135e-01 0.032 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.303416e-01 0.031 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.313440e-01 0.031 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.313440e-01 0.031 0 0
Heme degradation R-HSA-189483 9.313440e-01 0.031 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.313440e-01 0.031 0 0
GABA receptor activation R-HSA-977443 9.313636e-01 0.031 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.313636e-01 0.031 0 0
Interleukin-6 family signaling R-HSA-6783589 9.332909e-01 0.030 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.332909e-01 0.030 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.335380e-01 0.030 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.335566e-01 0.030 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.353653e-01 0.029 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.368271e-01 0.028 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.374481e-01 0.028 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.380542e-01 0.028 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 9.380542e-01 0.028 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.380542e-01 0.028 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.380542e-01 0.028 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 9.380542e-01 0.028 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.380542e-01 0.028 0 0
DNA Damage Reversal R-HSA-73942 9.380542e-01 0.028 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.381976e-01 0.028 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.381976e-01 0.028 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.408189e-01 0.026 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.408189e-01 0.026 0 0
Hyaluronan degradation R-HSA-2160916 9.408189e-01 0.026 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.419005e-01 0.026 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.464907e-01 0.024 0 0
Atorvastatin ADME R-HSA-9754706 9.464951e-01 0.024 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.464951e-01 0.024 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.464951e-01 0.024 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 9.464951e-01 0.024 0 0
Fructose catabolism R-HSA-70350 9.464951e-01 0.024 0 0
Differentiation of T cells R-HSA-9945266 9.464951e-01 0.024 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.464951e-01 0.024 0 0
N-Glycan antennae elongation R-HSA-975577 9.464951e-01 0.024 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.464951e-01 0.024 0 0
Killing mechanisms R-HSA-9664420 9.464951e-01 0.024 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.464951e-01 0.024 0 0
Attachment and Entry R-HSA-9678110 9.464951e-01 0.024 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.475346e-01 0.023 0 0
Sphingolipid catabolism R-HSA-9845614 9.475346e-01 0.023 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.475346e-01 0.023 0 0
TRP channels R-HSA-3295583 9.475346e-01 0.023 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.500437e-01 0.022 0 0
G1/S-Specific Transcription R-HSA-69205 9.500437e-01 0.022 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.500437e-01 0.022 0 0
IGF1R signaling cascade R-HSA-2428924 9.509677e-01 0.022 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.510297e-01 0.022 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.510297e-01 0.022 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.511940e-01 0.022 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.535194e-01 0.021 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.535194e-01 0.021 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.537862e-01 0.021 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.537862e-01 0.021 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.537862e-01 0.021 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.537862e-01 0.021 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.537862e-01 0.021 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.537862e-01 0.021 0 0
Passive transport by Aquaporins R-HSA-432047 9.537862e-01 0.021 0 0
Synthesis of PG R-HSA-1483148 9.537862e-01 0.021 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.537862e-01 0.021 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.537862e-01 0.021 0 0
Ion channel transport R-HSA-983712 9.543382e-01 0.020 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.550050e-01 0.020 0 0
Neddylation R-HSA-8951664 9.566103e-01 0.019 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.584257e-01 0.018 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.587390e-01 0.018 0 0
Telomere Extension By Telomerase R-HSA-171319 9.588478e-01 0.018 0 0
Pyroptosis R-HSA-5620971 9.588478e-01 0.018 0 0
Inflammasomes R-HSA-622312 9.588478e-01 0.018 0 0
Pyrimidine salvage R-HSA-73614 9.588478e-01 0.018 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.597435e-01 0.018 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.597633e-01 0.018 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.597633e-01 0.018 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.600841e-01 0.018 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.600841e-01 0.018 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.600841e-01 0.018 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.600841e-01 0.018 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.600841e-01 0.018 0 0
Choline catabolism R-HSA-6798163 9.600841e-01 0.018 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.600841e-01 0.018 0 0
IRS-mediated signalling R-HSA-112399 9.602721e-01 0.018 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.621892e-01 0.017 0 0
Gluconeogenesis R-HSA-70263 9.630583e-01 0.016 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.635876e-01 0.016 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.635876e-01 0.016 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.635876e-01 0.016 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.638023e-01 0.016 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.639017e-01 0.016 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.655240e-01 0.015 0 0
Tie2 Signaling R-HSA-210993 9.655240e-01 0.015 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.655240e-01 0.015 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.655240e-01 0.015 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.655240e-01 0.015 0 0
Integrin cell surface interactions R-HSA-216083 9.673592e-01 0.014 0 0
DAP12 signaling R-HSA-2424491 9.678002e-01 0.014 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.678002e-01 0.014 0 0
Activation of BH3-only proteins R-HSA-114452 9.678002e-01 0.014 0 0
PI3K Cascade R-HSA-109704 9.698028e-01 0.013 0 0
tRNA Aminoacylation R-HSA-379724 9.700115e-01 0.013 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.702229e-01 0.013 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.702229e-01 0.013 0 0
Specification of the neural plate border R-HSA-9834899 9.702229e-01 0.013 0 0
Amino Acid conjugation R-HSA-156587 9.702229e-01 0.013 0 0
Conjugation of carboxylic acids R-HSA-159424 9.702229e-01 0.013 0 0
Pyrimidine biosynthesis R-HSA-500753 9.702229e-01 0.013 0 0
Rap1 signalling R-HSA-392517 9.702229e-01 0.013 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.702229e-01 0.013 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.702229e-01 0.013 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.710333e-01 0.013 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.734327e-01 0.012 0 0
ECM proteoglycans R-HSA-3000178 9.735125e-01 0.012 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.740773e-01 0.011 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.740773e-01 0.011 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.742815e-01 0.011 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.742815e-01 0.011 0 0
Creatine metabolism R-HSA-71288 9.742815e-01 0.011 0 0
DAG1 glycosylations R-HSA-8931838 9.748609e-01 0.011 0 0
Infectious disease R-HSA-5663205 9.751535e-01 0.011 0 0
Signaling by PDGF R-HSA-186797 9.752212e-01 0.011 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.768158e-01 0.010 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.777872e-01 0.010 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.777872e-01 0.010 0 0
ERK/MAPK targets R-HSA-198753 9.777872e-01 0.010 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.777872e-01 0.010 0 0
Signalling to RAS R-HSA-167044 9.777872e-01 0.010 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.777872e-01 0.010 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.777872e-01 0.010 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.777872e-01 0.010 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.777872e-01 0.010 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.777939e-01 0.010 0 0
Nucleotide biosynthesis R-HSA-8956320 9.777939e-01 0.010 0 0
Recycling of bile acids and salts R-HSA-159418 9.778046e-01 0.010 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.778046e-01 0.010 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.779144e-01 0.010 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.782779e-01 0.010 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.794739e-01 0.009 0 0
Insulin receptor signalling cascade R-HSA-74751 9.795773e-01 0.009 0 0
Ion transport by P-type ATPases R-HSA-936837 9.795773e-01 0.009 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.804131e-01 0.009 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.808152e-01 0.008 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.808152e-01 0.008 0 0
Serine metabolism R-HSA-977347 9.808152e-01 0.008 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.808152e-01 0.008 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.827231e-01 0.008 0 0
eNOS activation R-HSA-203615 9.827231e-01 0.008 0 0
Hyaluronan metabolism R-HSA-2142845 9.827231e-01 0.008 0 0
RA biosynthesis pathway R-HSA-5365859 9.827231e-01 0.008 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.834305e-01 0.007 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.834305e-01 0.007 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.834305e-01 0.007 0 0
Ethanol oxidation R-HSA-71384 9.834305e-01 0.007 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.834305e-01 0.007 0 0
Signaling by KIT in disease R-HSA-9669938 9.834305e-01 0.007 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.834502e-01 0.007 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.847674e-01 0.007 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.847674e-01 0.007 0 0
Kidney development R-HSA-9830369 9.847870e-01 0.007 0 0
Interferon gamma signaling R-HSA-877300 9.855453e-01 0.006 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.856895e-01 0.006 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.856895e-01 0.006 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.856895e-01 0.006 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.856895e-01 0.006 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.856895e-01 0.006 0 0
Carnitine shuttle R-HSA-200425 9.856895e-01 0.006 0 0
Biosynthesis of maresins R-HSA-9018682 9.856895e-01 0.006 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.873747e-01 0.006 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.876406e-01 0.005 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.876406e-01 0.005 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.876406e-01 0.005 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.876406e-01 0.005 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.879132e-01 0.005 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.879182e-01 0.005 0 0
Voltage gated Potassium channels R-HSA-1296072 9.881740e-01 0.005 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.881855e-01 0.005 0 0
Triglyceride metabolism R-HSA-8979227 9.881855e-01 0.005 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.881855e-01 0.005 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.893258e-01 0.005 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.893258e-01 0.005 0 0
Fertilization R-HSA-1187000 9.893258e-01 0.005 0 0
Formation of the nephric duct R-HSA-9830364 9.893258e-01 0.005 0 0
PPARA activates gene expression R-HSA-1989781 9.896361e-01 0.005 0 0
Cardiac conduction R-HSA-5576891 9.903395e-01 0.004 0 0
Collagen degradation R-HSA-1442490 9.904686e-01 0.004 0 0
Azathioprine ADME R-HSA-9748787 9.906990e-01 0.004 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.907813e-01 0.004 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.907813e-01 0.004 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.908333e-01 0.004 0 0
Hemostasis R-HSA-109582 9.909228e-01 0.004 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.909822e-01 0.004 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.917213e-01 0.004 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.919340e-01 0.004 0 0
Diseases of Immune System R-HSA-5260271 9.919340e-01 0.004 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.919340e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.919340e-01 0.004 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.920384e-01 0.003 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.920384e-01 0.003 0 0
Signaling by BMP R-HSA-201451 9.920384e-01 0.003 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.920384e-01 0.003 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.920384e-01 0.003 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.920384e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.921315e-01 0.003 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.931241e-01 0.003 0 0
Phosphate bond hydrolysis by NTPDase proteins R-HSA-8850843 9.931241e-01 0.003 0 0
Insulin receptor recycling R-HSA-77387 9.931241e-01 0.003 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.931241e-01 0.003 0 0
Prednisone ADME R-HSA-9757110 9.931241e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.940619e-01 0.003 0 0
Immune System R-HSA-168256 9.945172e-01 0.002 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.948717e-01 0.002 0 0
Neurotransmitter clearance R-HSA-112311 9.948717e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.950404e-01 0.002 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.955712e-01 0.002 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.956438e-01 0.002 0 0
Parasite infection R-HSA-9664407 9.956438e-01 0.002 0 0
Leishmania phagocytosis R-HSA-9664417 9.956438e-01 0.002 0 0
DAP12 interactions R-HSA-2172127 9.957667e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.957667e-01 0.002 0 0
HS-GAG degradation R-HSA-2024096 9.961753e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.962823e-01 0.002 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.962823e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.962823e-01 0.002 0 0
Keratan sulfate biosynthesis R-HSA-2022854 9.966970e-01 0.001 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.967360e-01 0.001 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.967360e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.968338e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.970921e-01 0.001 0 0
Signaling by Insulin receptor R-HSA-74752 9.971191e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.971352e-01 0.001 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.971476e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.971519e-01 0.001 0 0
Toll-like Receptor Cascades R-HSA-168898 9.974388e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.974862e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.975368e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.975368e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.977948e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.978728e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.978728e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.978728e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.978728e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.981631e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.981631e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.981631e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.983043e-01 0.001 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.984137e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.984137e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.984137e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.984137e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.984685e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.985314e-01 0.001 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.986302e-01 0.001 0 0
Biofilm formation R-HSA-9931953 9.986302e-01 0.001 0 0
Purine salvage R-HSA-74217 9.986302e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.986302e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.986874e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.987695e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.988171e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.988461e-01 0.001 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.989786e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.989786e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.990001e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.990844e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.991180e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.991587e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.991995e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.992384e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.992565e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.992920e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.994199e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.994321e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.994758e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.994877e-01 0.000 0 0
Methylation R-HSA-156581 9.995096e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.995096e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.995096e-01 0.000 0 0
Disease R-HSA-1643685 9.995163e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.995501e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.996344e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996558e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.996622e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.996622e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.996843e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.996894e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.996894e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.997437e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997604e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.997646e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.997646e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.997871e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.997968e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997989e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997989e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.998243e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.998245e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.998245e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998828e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998828e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999158e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999251e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999251e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999406e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999409e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999410e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999458e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999542e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999596e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999600e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.999644e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999740e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999832e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999833e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999863e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999868e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999892e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999897e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.999907e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999916e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999920e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999921e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999940e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999948e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999948e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999967e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999970e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999971e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999975e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999979e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999981e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999982e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999983e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999983e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999986e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999987e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999988e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999990e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999993e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999994e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999997e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999997e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999999e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Initial triggering of complement R-HSA-166663 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways