CDK8

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O43852 T65 Sugiyama CALU FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60664 S175 Sugiyama PLIN3 M6PRBP1 TIP47 RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733 T55 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 VPsGAstGIyEALELRDNDKtRYMGKGVSKAVEHINKtIAP
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S470 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 Y457 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P10809 T105 Sugiyama HSPD1 HSP60 DLKDKYKNIGAKLVQDVANNtNEEAGDGtttAtVLARSIAK
P11142 S340 Sugiyama HSPA8 HSC70 HSP73 HSPA10 ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P13489 S178 Sugiyama RNH1 PRI RNH SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13639 S578 Sugiyama EEF2 EF2 LKDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNK
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 Y579 Sugiyama EEF2 EF2 KDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKH
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 S205 Sugiyama PKM OIP3 PK2 PK3 PKM2 VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22314 S820 Sugiyama UBA1 A1S9T UBE1 tPKsGVKIHVsDQELQsANAsVDDsRLEELKATLPsPDKLP
P30050 S165 Sugiyama RPL12 GRHPHDIIDDINsGAVECPAs____________________
P35579 S1714 Sugiyama MYH9 RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P42224 S727 SIGNOR|PSP STAT1 IsVsEVHPSRLQttDNLLPMsPEEFDEVSRIVGsVEFDSMM
P46531 S2513 SIGNOR|PSP NOTCH1 TAN1 PVDNTPSHQLQVPEHPFLtPsPEsPDQWssssPHSNVSDWS
P46531 S2516 SIGNOR|PSP NOTCH1 TAN1 NTPSHQLQVPEHPFLtPsPEsPDQWssssPHSNVSDWSEGV
P46531 T2511 SIGNOR|PSP NOTCH1 TAN1 SSPVDNTPSHQLQVPEHPFLtPsPEsPDQWssssPHSNVSD
P46937 S128 SIGNOR YAP1 YAP65 AstDAGtAGALtPQHVRAHssPAsLQLGAVsPGtLtPtGVV
P46937 S289 SIGNOR YAP1 YAP65 MNQRIsQsAPVKQPPPLAPQsPQGGVMGGsNsNQQQQMRLQ
P46937 S367 SIGNOR YAP1 YAP65 ALRSQLPtLEQDGGtQNPVssPGMsQELRTMttNssDPFLN
P46937 T119 SIGNOR YAP1 YAP65 PEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQLGAVsP
P49336 S244 Sugiyama CDK8 FAELLTSEPIFHCRQEDIKtsNPyHHDQLDRIFNVMGFPAD
P49336 T243 Sugiyama CDK8 IFAELLTSEPIFHCRQEDIKtsNPyHHDQLDRIFNVMGFPA
P49336 Y247 Sugiyama CDK8 LLTSEPIFHCRQEDIKtsNPyHHDQLDRIFNVMGFPADKDW
P51946 S304 GPS6|SIGNOR|iPTMNet|EPSD|PSP CCNH ELALNVITKKRKGYEDDDYVsKKSKHEEEEWtDDDLVEsL_
P51946 S5 GPS6|SIGNOR|iPTMNet|EPSD|PSP CCNH ________________MYHNsSQKRHWtFSsEEQLARLRAD
P52907 T224 Sugiyama CAPZA1 VQLVSHKDVQDsLtVsNEAQtAKEFIKIIENAENEyQTAIs
P60174 S198 Sugiyama TPI1 TPI TPQQAQEVHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtC
P60174 S204 Sugiyama TPI1 TPI EVHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQ
P60174 T205 Sugiyama TPI1 TPI VHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQP
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P61981 S38 Sugiyama YWHAG ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62942 S68 Sugiyama FKBP1A FKBP1 FKBP12 KFMLGKQEVIRGWEEGVAQMsVGQRAKLTISPDYAYGATGH
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63167 S21 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63167 T26 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68431 S11 SIGNOR|EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J __________MARtKQtARKstGGKAPRKQLATKAARKsAP
P84022 S208 SIGNOR|EPSD|PSP SMAD3 MADH3 DGETSDHQMNHSMDAGsPNLsPNPMsPAHNNLDLQPVTYCE
P84022 S213 SIGNOR|EPSD|PSP SMAD3 MADH3 DHQMNHSMDAGsPNLsPNPMsPAHNNLDLQPVTYCEPAFWC
P84022 T179 SIGNOR|EPSD|PSP SMAD3 MADH3 SIPENTNFPAGIEPQSNIPEtPPPGYLSEDGETSDHQMNHS
P84243 S11 SIGNOR H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B __________MARtKQTARKstGGKAPRKQLATKAARKsAP
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q01094 S375 SIGNOR|EPSD|PSP E2F1 RBBP3 QEPLLSRMGsLRAPVDEDRLsPLVAADSLLEHVREDFSGLL
Q13200 S16 Sugiyama PSMD2 TRAP2 _____MEEGGRDKAPVQPQQsPAAAPGGtDEKPsGKERRDA
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185 S118 Sugiyama PTGES3 P23 TEBP WLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGDEDVDL
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15797 S187 SIGNOR|EPSD|PSP SMAD1 BSP1 MADH1 MADR1 PLNATFPDSFQQPNSHPFPHsPNSSYPNsPGSSSStYPHsP
Q15797 S195 SIGNOR|EPSD|PSP SMAD1 BSP1 MADH1 MADR1 SFQQPNSHPFPHsPNSSYPNsPGSSSStYPHsPTSSDPGsP
Q15797 S206 SIGNOR|EPSD|PSP SMAD1 BSP1 MADH1 MADR1 HsPNSSYPNsPGSSSStYPHsPTSSDPGsPFQMPADTPPPA
Q15797 S214 SIGNOR|EPSD|PSP SMAD1 BSP1 MADH1 MADR1 NsPGSSSStYPHsPTSSDPGsPFQMPADTPPPAYLPPEDPM
Q16695 S11 SIGNOR H3-4 H3FT HIST3H3 __________MARtKQTARKsTGGKAPRKQLATKVARKsAP
Q6UVJ0 S283 Sugiyama SASS6 SAS6 DLTERKYKGDSTIRELKAKLsGVEEELQRTKQEVLSLRREN
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96D15 T72 Sugiyama RCN3 UNQ239/PRO272 FQYDHEAFLGREVAKEFDQLtPEEsQARLGRIVDRMDRAGD
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BX95 S112 Sugiyama SGPP1 SPP1 GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9UNE7 S23 Sugiyama STUB1 CHIP PP1131 GKEEKEGGARLGAGGGsPEKsPsAQELKEQGNRLFVGRKYP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.000007 5.155 0 0
Chromatin organization R-HSA-4839726 0.000011 4.962 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.000027 4.564 1 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.000069 4.161 0 0
Chromatin modifying enzymes R-HSA-3247509 0.000120 3.920 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.001018 2.992 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.000762 3.118 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.000706 3.151 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.000842 3.075 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.000908 3.042 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.001146 2.941 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.001101 2.958 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.000878 3.056 1 1
NRAGE signals death through JNK R-HSA-193648 0.001113 2.953 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.001319 2.880 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.001310 2.883 0 0
Notch-HLH transcription pathway R-HSA-350054 0.001431 2.844 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.001391 2.857 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.002224 2.653 0 0
Regulation of TP53 Activity R-HSA-5633007 0.002173 2.663 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.002955 2.530 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.002955 2.530 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.002766 2.558 1 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.002817 2.550 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.003662 2.436 0 0
Signaling by Leptin R-HSA-2586552 0.003721 2.429 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.004864 2.313 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.004820 2.317 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.004906 2.309 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.004756 2.323 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.004571 2.340 1 1
Signaling by ALK in cancer R-HSA-9700206 0.004756 2.323 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.004071 2.390 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.005425 2.266 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.005669 2.247 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.005669 2.247 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.006023 2.220 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.006023 2.220 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.007767 2.110 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.007854 2.105 0 0
Signaling by NOTCH1 R-HSA-1980143 0.007473 2.127 1 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.007854 2.105 0 0
TGFBR3 expression R-HSA-9839394 0.008955 2.048 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.008764 2.057 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.009815 2.008 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.010066 1.997 0 0
Interleukin-15 signaling R-HSA-8983432 0.009815 2.008 0 0
RET signaling R-HSA-8853659 0.010061 1.997 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.010831 1.965 1 1
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.010831 1.965 1 1
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.010831 1.965 1 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.010831 1.965 1 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.010831 1.965 1 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.011453 1.941 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.011453 1.941 1 0
NGF-stimulated transcription R-HSA-9031628 0.011569 1.937 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.011755 1.930 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.011011 1.958 0 0
Death Receptor Signaling R-HSA-73887 0.012453 1.905 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.012934 1.888 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.013517 1.869 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.013517 1.869 0 0
Cardiogenesis R-HSA-9733709 0.013517 1.869 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.014163 1.849 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.015786 1.802 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 0.016575 1.781 0 0
Adipogenesis R-HSA-9843745 0.016226 1.790 1 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.018152 1.741 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.017650 1.753 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.017919 1.747 0 0
G alpha (12/13) signalling events R-HSA-416482 0.018492 1.733 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 0.018982 1.722 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.021352 1.671 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.021352 1.671 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.021352 1.671 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.021352 1.671 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.021352 1.671 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.020932 1.679 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.021349 1.671 0 0
FLT3 Signaling R-HSA-9607240 0.020772 1.683 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.020487 1.689 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.021338 1.671 0 0
RUNX2 regulates bone development R-HSA-8941326 0.024439 1.612 0 0
G1/S-Specific Transcription R-HSA-69205 0.024439 1.612 0 0
HATs acetylate histones R-HSA-3214847 0.024902 1.604 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.024902 1.604 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.027578 1.559 0 0
Heme signaling R-HSA-9707616 0.027952 1.554 0 0
Signaling by TGFB family members R-HSA-9006936 0.030047 1.522 1 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.030259 1.519 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.031836 1.497 0 0
Repression of WNT target genes R-HSA-4641265 0.034868 1.458 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.032812 1.484 1 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.034868 1.458 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.033023 1.481 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.035758 1.447 1 0
Specification of primordial germ cells R-HSA-9827857 0.038456 1.415 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.038456 1.415 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.037739 1.423 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.036795 1.434 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.037869 1.422 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.037869 1.422 0 0
Signaling by Hippo R-HSA-2028269 0.038456 1.415 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 0.044689 1.350 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.044689 1.350 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.044689 1.350 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.044689 1.350 0 0
IRS activation R-HSA-74713 0.044351 1.353 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.044351 1.353 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.044351 1.353 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.043246 1.364 0 0
Polo-like kinase mediated events R-HSA-156711 0.045892 1.338 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.044818 1.349 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.044351 1.353 0 0
Interleukin-2 family signaling R-HSA-451927 0.040607 1.391 0 0
Nuclear import of Rev protein R-HSA-180746 0.042894 1.368 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.041133 1.386 0 0
Signaling by FGFR in disease R-HSA-1226099 0.045059 1.346 0 0
Interleukin-21 signaling R-HSA-9020958 0.046568 1.332 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.046568 1.332 0 0
Growth hormone receptor signaling R-HSA-982772 0.046026 1.337 0 0
Circadian clock R-HSA-9909396 0.046868 1.329 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.048501 1.314 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.052731 1.278 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.053257 1.274 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.051170 1.291 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.051170 1.291 0 0
Signaling by NOTCH3 R-HSA-9012852 0.053310 1.273 0 0
Activation of BH3-only proteins R-HSA-114452 0.051170 1.291 0 0
Signal Transduction R-HSA-162582 0.050358 1.298 1 0
Interleukin-37 signaling R-HSA-9008059 0.051170 1.291 0 0
Cell Cycle R-HSA-1640170 0.053425 1.272 0 0
MAPK3 (ERK1) activation R-HSA-110056 0.058960 1.229 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.054162 1.266 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.058076 1.236 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.058076 1.236 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.058615 1.232 1 1
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.055760 1.254 0 0
Signal attenuation R-HSA-74749 0.058960 1.229 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.054162 1.266 0 0
Formation of intermediate mesoderm R-HSA-9761174 0.058960 1.229 0 0
Signaling by NTRKs R-HSA-166520 0.055618 1.255 0 0
Downstream signal transduction R-HSA-186763 0.058076 1.236 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.056719 1.246 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.061138 1.214 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.061138 1.214 0 0
Signaling by RNF43 mutants R-HSA-5340588 0.061138 1.214 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.063333 1.198 0 0
Formation of definitive endoderm R-HSA-9823730 0.063278 1.199 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.063278 1.199 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.063278 1.199 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.063278 1.199 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.063278 1.199 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.063278 1.199 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.065543 1.183 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.062246 1.206 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.065543 1.183 0 0
Signaling by SCF-KIT R-HSA-1433557 0.062904 1.201 0 0
Long-term potentiation R-HSA-9620244 0.061161 1.214 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.067152 1.173 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.068324 1.165 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.069745 1.156 0 0
Regulation of TP53 Expression R-HSA-6804754 0.073957 1.131 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.080433 1.095 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.080433 1.095 0 0
STAT5 Activation R-HSA-9645135 0.080433 1.095 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.073242 1.135 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.073577 1.133 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.073577 1.133 0 0
Prolonged ERK activation events R-HSA-169893 0.075043 1.125 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.076471 1.117 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.073577 1.133 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.079011 1.102 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.077976 1.108 0 0
Interleukin-2 signaling R-HSA-9020558 0.072929 1.137 0 0
Mitotic Prometaphase R-HSA-68877 0.079993 1.097 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.080433 1.095 0 0
Signaling by ALK R-HSA-201556 0.075655 1.121 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.073957 1.131 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.073242 1.135 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.082180 1.085 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.082180 1.085 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.082180 1.085 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.082180 1.085 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.083654 1.078 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.083654 1.078 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.083654 1.078 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.083654 1.078 0 0
Signaling by TGFBR3 R-HSA-9839373 0.083988 1.076 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.084049 1.075 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.087843 1.056 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 0.105263 0.978 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 0.105263 0.978 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 0.105263 0.978 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 0.105263 0.978 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 0.199450 0.700 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 0.199450 0.700 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 0.199450 0.700 0 0
MET interacts with TNS proteins R-HSA-8875513 0.107649 0.968 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 0.107649 0.968 0 0
Regulation of gap junction activity R-HSA-191650 0.144510 0.840 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.144510 0.840 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.144510 0.840 0 0
Intestinal infectious diseases R-HSA-8942233 0.283728 0.547 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 0.283728 0.547 0 0
Defective VWF binding to collagen type I R-HSA-9845622 0.283728 0.547 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 0.283728 0.547 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.102000 0.991 0 0
Regulation of PTEN localization R-HSA-8948747 0.102000 0.991 0 0
SOS-mediated signalling R-HSA-112412 0.102000 0.991 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.183502 0.736 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 0.125576 0.901 0 0
MET receptor recycling R-HSA-8875656 0.125576 0.901 0 0
Anchoring fibril formation R-HSA-2214320 0.088418 1.053 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.105348 0.977 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.150884 0.821 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.150884 0.821 0 0
ALK mutants bind TKIs R-HSA-9700645 0.150884 0.821 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.223767 0.650 0 0
Cam-PDE 1 activation R-HSA-111957 0.223767 0.650 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.359138 0.445 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.359138 0.445 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 0.359138 0.445 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 0.359138 0.445 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 0.359138 0.445 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.359138 0.445 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.359138 0.445 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 0.359138 0.445 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 0.359138 0.445 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.359138 0.445 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.359138 0.445 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.359138 0.445 0 0
Defective ABCD1 causes ALD R-HSA-5684045 0.359138 0.445 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.359138 0.445 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.359138 0.445 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.359138 0.445 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.359138 0.445 0 0
Interleukin-6 signaling R-HSA-1059683 0.123623 0.908 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.123623 0.908 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.123623 0.908 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.177640 0.750 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.177640 0.750 0 0
G2/M DNA replication checkpoint R-HSA-69478 0.264607 0.577 0 0
DCC mediated attractive signaling R-HSA-418885 0.163761 0.786 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.185377 0.732 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.234398 0.630 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.234398 0.630 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.234398 0.630 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.234398 0.630 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 0.234398 0.630 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.305454 0.515 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.305454 0.515 0 0
PTK6 Expression R-HSA-8849473 0.305454 0.515 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 0.305454 0.515 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.305454 0.515 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.305454 0.515 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.305454 0.515 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 0.426613 0.370 0 0
MET activates STAT3 R-HSA-8875791 0.426613 0.370 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 0.426613 0.370 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 0.426613 0.370 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 0.426613 0.370 0 0
MET activates PTPN11 R-HSA-8865999 0.426613 0.370 0 0
Classical Kir channels R-HSA-1296053 0.426613 0.370 0 0
Signalling to STAT3 R-HSA-198745 0.426613 0.370 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.426613 0.370 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.426613 0.370 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.135380 0.868 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.166744 0.778 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.263878 0.579 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.122224 0.913 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.345854 0.461 0 0
Formation of annular gap junctions R-HSA-196025 0.345854 0.461 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.345854 0.461 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.345854 0.461 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.204143 0.690 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.293772 0.532 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.145491 0.837 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.254843 0.594 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.223804 0.650 0 0
Signaling by Erythropoietin R-HSA-9006335 0.198157 0.703 0 0
RAF activation R-HSA-5673000 0.176483 0.753 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.104138 0.982 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.153032 0.815 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.153032 0.815 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.153032 0.815 0 0
Deadenylation of mRNA R-HSA-429947 0.244000 0.613 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.279101 0.554 0 0
ARMS-mediated activation R-HSA-170984 0.385449 0.414 0 0
Gap junction degradation R-HSA-190873 0.385449 0.414 0 0
HCN channels R-HSA-1296061 0.486987 0.312 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 0.486987 0.312 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.486987 0.312 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 0.486987 0.312 0 0
Signaling by LRP5 mutants R-HSA-5339717 0.486987 0.312 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.486987 0.312 0 0
Signaling by MAP2K mutants R-HSA-9652169 0.486987 0.312 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.120225 0.920 0 0
MAP2K and MAPK activation R-HSA-5674135 0.184079 0.735 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.184079 0.735 0 0
Signaling by ERBB4 R-HSA-1236394 0.132588 0.877 0 0
G0 and Early G1 R-HSA-1538133 0.251032 0.600 0 0
Erythropoietin activates RAS R-HSA-9027284 0.353952 0.451 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.173548 0.761 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.173548 0.761 0 0
DNA replication initiation R-HSA-68952 0.423962 0.373 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 0.423962 0.373 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 0.383867 0.416 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 0.383867 0.416 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.271596 0.566 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.207195 0.684 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.197371 0.705 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.353436 0.452 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 0.353436 0.452 0 0
Centrosome maturation R-HSA-380287 0.219534 0.658 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.305973 0.514 0 0
HIV Transcription Initiation R-HSA-167161 0.305973 0.514 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.305973 0.514 0 0
Late endosomal microautophagy R-HSA-9615710 0.350198 0.456 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.350198 0.456 0 0
FGFR2 alternative splicing R-HSA-6803529 0.378358 0.422 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.461180 0.336 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.461180 0.336 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.461180 0.336 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.461180 0.336 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 0.541007 0.267 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 0.541007 0.267 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 0.541007 0.267 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 0.541007 0.267 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 0.541007 0.267 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 0.541007 0.267 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 0.541007 0.267 0 0
Activation of the pre-replicative complex R-HSA-68962 0.371940 0.430 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.341139 0.467 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.264443 0.578 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 0.442568 0.354 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.294775 0.531 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.291420 0.535 0 0
snRNP Assembly R-HSA-191859 0.331274 0.480 0 0
Metabolism of non-coding RNA R-HSA-194441 0.331274 0.480 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.288003 0.541 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.304038 0.517 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.496951 0.304 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.346583 0.460 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.376767 0.424 0 0
Nucleosome assembly R-HSA-774815 0.376767 0.424 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.376767 0.424 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.471101 0.327 0 0
Ephrin signaling R-HSA-3928664 0.471101 0.327 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.423933 0.373 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.458269 0.339 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.458269 0.339 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.498953 0.302 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.531165 0.275 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.531165 0.275 0 0
Leading Strand Synthesis R-HSA-69109 0.531165 0.275 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.531165 0.275 0 0
Polymerase switching R-HSA-69091 0.531165 0.275 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.531165 0.275 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.531165 0.275 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.531165 0.275 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.531165 0.275 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.531165 0.275 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.589341 0.230 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 0.589341 0.230 0 0
PKB-mediated events R-HSA-109703 0.589341 0.230 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.589341 0.230 0 0
PDE3B signalling R-HSA-165160 0.589341 0.230 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.589341 0.230 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 0.589341 0.230 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 0.589341 0.230 0 0
Signaling by MAPK mutants R-HSA-9652817 0.589341 0.230 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.589341 0.230 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 0.589341 0.230 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.499777 0.301 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.499777 0.301 0 0
Separation of Sister Chromatids R-HSA-2467813 0.376547 0.424 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.481668 0.317 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.563755 0.249 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.485871 0.313 0 0
PPARA activates gene expression R-HSA-1989781 0.461489 0.336 1 1
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.552295 0.258 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.527347 0.278 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.555549 0.255 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.577666 0.238 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.577666 0.238 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.594683 0.226 0 0
Removal of the Flap Intermediate R-HSA-69166 0.594683 0.226 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.632589 0.199 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 0.632589 0.199 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 0.632589 0.199 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 0.632589 0.199 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.632589 0.199 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 0.632589 0.199 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 0.632589 0.199 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.602112 0.220 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.610832 0.214 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.609736 0.215 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.623938 0.205 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.623938 0.205 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.625605 0.204 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.625605 0.204 0 0
Termination of O-glycan biosynthesis R-HSA-977068 0.625605 0.204 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.645724 0.190 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.652291 0.186 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.651529 0.186 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.671284 0.173 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 0.671284 0.173 0 0
Netrin mediated repulsion signals R-HSA-418886 0.671284 0.173 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 0.671284 0.173 0 0
Recycling of eIF2:GDP R-HSA-72731 0.671284 0.173 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 0.671284 0.173 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.677481 0.169 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.703474 0.153 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.701835 0.154 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.325237 0.488 0 0
PTEN Regulation R-HSA-6807070 0.157885 0.802 0 0
Transcription of the HIV genome R-HSA-167172 0.608722 0.216 0 0
Cellular response to heat stress R-HSA-3371556 0.251694 0.599 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.179590 0.746 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.135600 0.868 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.393126 0.405 1 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.300645 0.522 1 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.300645 0.522 1 1
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.300645 0.522 1 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.254569 0.594 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.161238 0.793 0 0
Aggrephagy R-HSA-9646399 0.157883 0.802 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.095689 1.019 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 0.413451 0.384 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.379413 0.421 0 0
Crosslinking of collagen fibrils R-HSA-2243919 0.498953 0.302 0 0
FOXO-mediated transcription R-HSA-9614085 0.172314 0.764 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.244000 0.613 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.303698 0.518 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.323862 0.490 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.531165 0.275 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.305973 0.514 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.123623 0.908 0 0
Homology Directed Repair R-HSA-5693538 0.157849 0.802 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.637239 0.196 0 0
Chromosome Maintenance R-HSA-73886 0.433443 0.363 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.143134 0.844 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.499777 0.301 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.567525 0.246 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.623938 0.205 0 0
Interleukin-6 family signaling R-HSA-6783589 0.244000 0.613 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.172953 0.762 0 0
Frs2-mediated activation R-HSA-170968 0.123623 0.908 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.468434 0.329 0 0
Neurexins and neuroligins R-HSA-6794361 0.352642 0.453 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.269478 0.569 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.413451 0.384 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.427812 0.369 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.377476 0.423 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.634964 0.197 0 0
Signaling by ERBB2 R-HSA-1227986 0.230502 0.637 0 0
Signaling by BMP R-HSA-201451 0.306990 0.513 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.602198 0.220 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.204143 0.690 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.413451 0.384 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.307642 0.512 0 0
Mitotic Anaphase R-HSA-68882 0.467593 0.330 0 0
COPII-mediated vesicle transport R-HSA-204005 0.637239 0.196 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.350198 0.456 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 0.385449 0.414 0 0
Signaling by Activin R-HSA-1502540 0.353952 0.451 0 0
PI3K/AKT activation R-HSA-198203 0.423962 0.373 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.413451 0.384 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.461180 0.336 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.281632 0.550 0 0
RNA Polymerase III Transcription R-HSA-74158 0.703474 0.153 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.701835 0.154 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.468434 0.329 0 0
DNA Double Strand Break Response R-HSA-5693606 0.594040 0.226 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.476317 0.322 0 0
Signaling by RAS mutants R-HSA-6802949 0.153032 0.815 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.496951 0.304 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.354005 0.451 0 0
p75NTR signals via NF-kB R-HSA-193639 0.623938 0.205 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.685337 0.164 0 0
Insulin receptor signalling cascade R-HSA-74751 0.548463 0.261 0 0
Dopamine receptors R-HSA-390651 0.144510 0.840 0 0
Interleukin-23 signaling R-HSA-9020933 0.125576 0.901 0 0
Activation of RAC1 R-HSA-428540 0.088418 1.053 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.105348 0.977 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.163761 0.786 0 0
Adrenoceptors R-HSA-390696 0.345854 0.461 0 0
Formation of axial mesoderm R-HSA-9796292 0.293772 0.532 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.486987 0.312 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.208325 0.681 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.326365 0.486 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.471101 0.327 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.645724 0.190 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.326399 0.486 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.156733 0.805 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.156733 0.805 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.564540 0.248 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.378358 0.422 0 0
DNA Damage Bypass R-HSA-73893 0.607579 0.216 0 0
Laminin interactions R-HSA-3000157 0.452171 0.345 0 0
M Phase R-HSA-68886 0.335420 0.474 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 0.442568 0.354 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.531165 0.275 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.456311 0.341 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.651052 0.186 0 0
G2/M Checkpoints R-HSA-69481 0.613776 0.212 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.101114 0.995 0 0
Mitotic Prophase R-HSA-68875 0.242299 0.616 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 0.651529 0.186 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.690604 0.161 0 0
Reproduction R-HSA-1474165 0.557265 0.254 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.403180 0.395 0 0
Signaling by WNT in cancer R-HSA-4791275 0.251032 0.600 0 0
Netrin-1 signaling R-HSA-373752 0.519163 0.285 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 0.107649 0.968 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.110855 0.955 0 0
Calcineurin activates NFAT R-HSA-2025928 0.385449 0.414 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.486987 0.312 0 0
Signaling by NODAL R-HSA-1181150 0.303698 0.518 0 0
MET promotes cell motility R-HSA-8875878 0.238339 0.623 0 0
Josephin domain DUBs R-HSA-5689877 0.423962 0.373 0 0
PTK6 Activates STAT3 R-HSA-8849474 0.541007 0.267 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.541007 0.267 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.496951 0.304 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.252286 0.598 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.452171 0.345 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.383970 0.416 0 0
Signaling by NOTCH R-HSA-157118 0.444691 0.352 1 0
IRS-mediated signalling R-HSA-112399 0.584238 0.233 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.671284 0.173 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.677481 0.169 0 0
Interleukin-20 family signaling R-HSA-8854691 0.223804 0.650 0 0
Signalling to ERKs R-HSA-187687 0.191268 0.718 0 0
Cellular Senescence R-HSA-2559583 0.297350 0.527 0 0
IGF1R signaling cascade R-HSA-2428924 0.688144 0.162 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 0.563755 0.249 0 0
Cilium Assembly R-HSA-5617833 0.309594 0.509 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.231052 0.636 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.342675 0.465 0 0
Gene expression (Transcription) R-HSA-74160 0.171924 0.765 1 0
Oncogene Induced Senescence R-HSA-2559585 0.500236 0.301 0 0
Developmental Biology R-HSA-1266738 0.421727 0.375 1 0
RNA Polymerase II Transcription R-HSA-73857 0.226117 0.646 1 0
Regulation of KIT signaling R-HSA-1433559 0.143134 0.844 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.651529 0.186 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.669666 0.174 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.435357 0.361 0 0
TNF signaling R-HSA-75893 0.106693 0.972 0 0
MTOR signalling R-HSA-165159 0.652291 0.186 0 0
Cell Cycle, Mitotic R-HSA-69278 0.150395 0.823 0 0
Interleukin-35 Signalling R-HSA-8984722 0.263878 0.579 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.193120 0.714 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.180691 0.743 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.443327 0.353 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.153032 0.815 0 0
Generic Transcription Pathway R-HSA-212436 0.178545 0.748 1 1
Intracellular signaling by second messengers R-HSA-9006925 0.159743 0.797 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.144510 0.840 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.144510 0.840 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 0.125576 0.901 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 0.223767 0.650 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.143134 0.844 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.095689 1.019 0 0
FasL/ CD95L signaling R-HSA-75157 0.426613 0.370 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.285673 0.544 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.238339 0.623 0 0
Nuclear RNA decay R-HSA-9930044 0.269478 0.569 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.135626 0.868 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 0.496951 0.304 0 0
HDACs deacetylate histones R-HSA-3214815 0.402324 0.395 0 0
MET activates RAS signaling R-HSA-8851805 0.531165 0.275 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.446704 0.350 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.579925 0.237 0 0
FLT3 signaling in disease R-HSA-9682385 0.206531 0.685 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.646890 0.189 0 0
Cyclin D associated events in G1 R-HSA-69231 0.685337 0.164 0 0
G1 Phase R-HSA-69236 0.685337 0.164 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.095689 1.019 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.088957 1.051 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.217415 0.663 0 0
Membrane Trafficking R-HSA-199991 0.309086 0.510 0 0
DNA Repair R-HSA-73894 0.355811 0.449 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.701534 0.154 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.110855 0.955 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.170753 0.768 0 0
Rap1 signalling R-HSA-392517 0.498953 0.302 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.499777 0.301 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.608722 0.216 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.176483 0.753 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.651052 0.186 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.277681 0.556 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.498953 0.302 0 0
PERK regulates gene expression R-HSA-381042 0.686124 0.164 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.636891 0.196 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.095689 1.019 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.412322 0.385 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.703474 0.153 0 0
HDMs demethylate histones R-HSA-3214842 0.264650 0.577 0 0
Gastrulation R-HSA-9758941 0.177919 0.750 0 0
Cell Cycle Checkpoints R-HSA-69620 0.200307 0.698 0 0
Nervous system development R-HSA-9675108 0.421933 0.375 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.230824 0.637 0 0
Signaling by MET R-HSA-6806834 0.390321 0.409 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.400464 0.397 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.144510 0.840 0 0
Transport of connexins along the secretory pathway R-HSA-190827 0.283728 0.547 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 0.283728 0.547 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.183502 0.736 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.150884 0.821 0 0
TGFBR3 regulates activin signaling R-HSA-9839406 0.359138 0.445 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.123623 0.908 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.116575 0.933 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.426613 0.370 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.426613 0.370 0 0
Signaling by LTK R-HSA-9842663 0.263878 0.579 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.122224 0.913 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.176483 0.753 0 0
Kinesins R-HSA-983189 0.142779 0.845 0 0
Interleukin-7 signaling R-HSA-1266695 0.264650 0.577 0 0
TBC/RABGAPs R-HSA-8854214 0.211996 0.674 0 0
Interleukin-27 signaling R-HSA-9020956 0.423962 0.373 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.241413 0.617 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.243536 0.613 0 0
Disorders of Developmental Biology R-HSA-9675151 0.413451 0.384 0 0
Ionotropic activity of kainate receptors R-HSA-451306 0.461180 0.336 0 0
Signaling by APC mutants R-HSA-4839744 0.461180 0.336 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 0.442568 0.354 0 0
ESR-mediated signaling R-HSA-8939211 0.133477 0.875 0 0
Budding and maturation of HIV virion R-HSA-162588 0.393682 0.405 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.496951 0.304 0 0
Signaling by AXIN mutants R-HSA-4839735 0.496951 0.304 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.471101 0.327 0 0
Mitochondrial biogenesis R-HSA-1592230 0.294717 0.531 0 0
TRAIL signaling R-HSA-75158 0.589341 0.230 0 0
Sensory perception of salty taste R-HSA-9730628 0.589341 0.230 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.589341 0.230 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 0.563755 0.249 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.488321 0.311 0 0
Agmatine biosynthesis R-HSA-351143 0.632589 0.199 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 0.632589 0.199 0 0
Ub-specific processing proteases R-HSA-5689880 0.645627 0.190 0 0
PI3K Cascade R-HSA-109704 0.624159 0.205 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.651529 0.186 0 0
Myogenesis R-HSA-525793 0.690223 0.161 0 0
G2/M Transition R-HSA-69275 0.511553 0.291 0 0
MAPK family signaling cascades R-HSA-5683057 0.225774 0.646 0 0
Axon guidance R-HSA-422475 0.616567 0.210 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.530176 0.276 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.471101 0.327 0 0
Collagen degradation R-HSA-1442490 0.243536 0.613 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.127656 0.894 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.323862 0.490 0 0
Interleukin-9 signaling R-HSA-8985947 0.125576 0.901 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.264650 0.577 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.648126 0.188 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.230502 0.637 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.209160 0.680 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.101367 0.994 0 0
HIV Life Cycle R-HSA-162587 0.393126 0.405 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.629863 0.201 0 0
G1/S Transition R-HSA-69206 0.592221 0.228 0 0
Deubiquitination R-HSA-5688426 0.233159 0.632 0 0
Differentiation of T cells R-HSA-9945266 0.383867 0.416 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.383867 0.416 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.377476 0.423 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.341139 0.467 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.177640 0.750 0 0
MDK and PTN in ALK signaling R-HSA-9851151 0.486987 0.312 0 0
Rab regulation of trafficking R-HSA-9007101 0.150604 0.822 0 0
tRNA processing in the nucleus R-HSA-6784531 0.256825 0.590 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.326503 0.486 0 0
Regulation of signaling by CBL R-HSA-912631 0.498953 0.302 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.479396 0.319 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.623938 0.205 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.623938 0.205 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.496203 0.304 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.143722 0.842 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.165499 0.781 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.230462 0.637 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.588949 0.230 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.244000 0.613 0 0
Neurodegenerative Diseases R-HSA-8863678 0.244000 0.613 0 0
MAP kinase activation R-HSA-450294 0.645724 0.190 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 0.183502 0.736 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 0.486987 0.312 0 0
Specification of the neural plate border R-HSA-9834899 0.498953 0.302 0 0
Pervasive developmental disorders R-HSA-9005895 0.531165 0.275 0 0
Disorders of Nervous System Development R-HSA-9697154 0.531165 0.275 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.531165 0.275 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.589341 0.230 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 0.594683 0.226 0 0
Interleukin-17 signaling R-HSA-448424 0.637239 0.196 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.671284 0.173 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.181294 0.742 0 0
Selective autophagy R-HSA-9663891 0.636710 0.196 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.701835 0.154 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.701835 0.154 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.473837 0.324 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.545496 0.263 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.358518 0.445 0 0
Formation of the nephric duct R-HSA-9830364 0.452171 0.345 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.148483 0.828 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.393682 0.405 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.476181 0.322 0 0
UCH proteinases R-HSA-5689603 0.457753 0.339 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.701835 0.154 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.198157 0.703 0 0
Diseases of programmed cell death R-HSA-9645723 0.636710 0.196 0 0
Signaling by KIT in disease R-HSA-9669938 0.204143 0.690 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.513290 0.290 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.269478 0.569 0 0
Semaphorin interactions R-HSA-373755 0.674375 0.171 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.130891 0.883 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.104138 0.982 0 0
Signaling by PTK6 R-HSA-8848021 0.104138 0.982 0 0
Oligomerization of connexins into connexons R-HSA-190704 0.283728 0.547 0 0
MAPK1 (ERK2) activation R-HSA-112411 0.150884 0.821 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.223767 0.650 0 0
DSCAM interactions R-HSA-376172 0.359138 0.445 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.185097 0.733 0 0
Synthesis of PI R-HSA-1483226 0.461180 0.336 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 0.589341 0.230 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.552295 0.258 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.594683 0.226 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.594683 0.226 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 0.632589 0.199 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.579925 0.237 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.629863 0.201 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.648126 0.188 0 0
Negative regulation of FLT3 R-HSA-9706369 0.651529 0.186 0 0
Killing mechanisms R-HSA-9664420 0.651529 0.186 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.651529 0.186 0 0
VLDL clearance R-HSA-8964046 0.671284 0.173 0 0
PI Metabolism R-HSA-1483255 0.198814 0.702 0 0
Regulation of beta-cell development R-HSA-186712 0.331274 0.480 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.430396 0.366 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.669666 0.174 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.256825 0.590 0 0
NCAM1 interactions R-HSA-419037 0.365377 0.437 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.496951 0.304 0 0
PKR-mediated signaling R-HSA-9833482 0.643326 0.192 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.163761 0.786 0 0
Collagen chain trimerization R-HSA-8948216 0.122224 0.913 0 0
Prolactin receptor signaling R-HSA-1170546 0.323862 0.490 0 0
PECAM1 interactions R-HSA-210990 0.461180 0.336 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.223957 0.650 0 0
Tie2 Signaling R-HSA-210993 0.471101 0.327 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.608722 0.216 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 0.690223 0.161 0 0
GPVI-mediated activation cascade R-HSA-114604 0.703474 0.153 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.555022 0.256 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.703137 0.153 0 0
MHC class II antigen presentation R-HSA-2132295 0.558986 0.253 0 0
Diseases of DNA repair R-HSA-9675135 0.153032 0.815 0 0
Metabolism of folate and pterines R-HSA-196757 0.540888 0.267 0 0
NrCAM interactions R-HSA-447038 0.183502 0.736 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.305454 0.515 0 0
Fibronectin matrix formation R-HSA-1566977 0.207851 0.682 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.263878 0.579 0 0
Sodium/Proton exchangers R-HSA-425986 0.345854 0.461 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.157883 0.802 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.170753 0.768 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.385449 0.414 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 0.486987 0.312 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 0.486987 0.312 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.269478 0.569 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.541007 0.267 0 0
Relaxin receptors R-HSA-444821 0.589341 0.230 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.577666 0.238 0 0
cGMP effects R-HSA-418457 0.594683 0.226 0 0
CREB phosphorylation R-HSA-199920 0.632589 0.199 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 0.671284 0.173 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 0.671284 0.173 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.690223 0.161 0 0
Inositol phosphate metabolism R-HSA-1483249 0.407387 0.390 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.617116 0.210 0 0
Biotin transport and metabolism R-HSA-196780 0.623938 0.205 0 0
Sensory processing of sound R-HSA-9659379 0.630121 0.201 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.690223 0.161 0 0
RMTs methylate histone arginines R-HSA-3214858 0.685337 0.164 0 0
Signaling by PDGF R-HSA-186797 0.162956 0.788 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.223804 0.650 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.531165 0.275 0 0
L1CAM interactions R-HSA-373760 0.583886 0.234 0 0
Other semaphorin interactions R-HSA-416700 0.623938 0.205 0 0
tRNA modification in the mitochondrion R-HSA-6787450 0.677481 0.169 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.542878 0.265 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.345854 0.461 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.133599 0.874 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.385449 0.414 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.256611 0.591 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.442568 0.354 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 0.589341 0.230 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 0.589341 0.230 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 0.589341 0.230 0 0
HDL clearance R-HSA-8964011 0.632589 0.199 0 0
Nef and signal transduction R-HSA-164944 0.632589 0.199 0 0
Formation of the anterior neural plate R-HSA-9823739 0.623938 0.205 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 0.651529 0.186 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 0.671284 0.173 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.207851 0.682 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.145491 0.837 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.651529 0.186 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.701835 0.154 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.541007 0.267 0 0
Neurofascin interactions R-HSA-447043 0.632589 0.199 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.594683 0.226 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.568071 0.246 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.574827 0.240 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.649312 0.188 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.609736 0.215 0 0
Meiosis R-HSA-1500620 0.705224 0.152 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.705906 0.151 0 0
Regulation by c-FLIP R-HSA-3371378 0.705906 0.151 0 0
phospho-PLA2 pathway R-HSA-111995 0.705906 0.151 0 0
Dimerization of procaspase-8 R-HSA-69416 0.705906 0.151 0 0
Activation of RAS in B cells R-HSA-1169092 0.705906 0.151 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 0.705906 0.151 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.705906 0.151 0 0
Type I hemidesmosome assembly R-HSA-446107 0.705906 0.151 0 0
Co-stimulation by ICOS R-HSA-9927354 0.705906 0.151 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.705906 0.151 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 0.705906 0.151 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.709802 0.149 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.709802 0.149 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.709802 0.149 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.709802 0.149 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.709802 0.149 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.710241 0.149 0 0
Signaling by EGFR R-HSA-177929 0.714650 0.146 0 0
Apoptotic execution phase R-HSA-75153 0.716191 0.145 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.720120 0.143 0 0
GAB1 signalosome R-HSA-180292 0.724638 0.140 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.724638 0.140 0 0
Mismatch Repair R-HSA-5358508 0.724638 0.140 0 0
Platelet sensitization by LDL R-HSA-432142 0.724638 0.140 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 0.724638 0.140 0 0
Kidney development R-HSA-9830369 0.727158 0.138 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.727201 0.138 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.728414 0.138 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.728414 0.138 0 0
HIV elongation arrest and recovery R-HSA-167287 0.728414 0.138 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.728414 0.138 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.732640 0.135 0 0
Cell junction organization R-HSA-446728 0.733072 0.135 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.736064 0.133 0 0
CASP8 activity is inhibited R-HSA-5218900 0.736883 0.133 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.736883 0.133 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.736883 0.133 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.736883 0.133 0 0
Unwinding of DNA R-HSA-176974 0.736883 0.133 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.736883 0.133 0 0
Regulation of signaling by NODAL R-HSA-1433617 0.736883 0.133 0 0
WNT mediated activation of DVL R-HSA-201688 0.736883 0.133 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 0.736883 0.133 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.736883 0.133 0 0
Lipophagy R-HSA-9613354 0.736883 0.133 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 0.736883 0.133 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.736883 0.133 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.736883 0.133 0 0
Post NMDA receptor activation events R-HSA-438064 0.738868 0.131 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.745948 0.127 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.745948 0.127 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.745948 0.127 0 0
Other interleukin signaling R-HSA-449836 0.745948 0.127 0 0
mRNA Capping R-HSA-72086 0.746075 0.127 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.746075 0.127 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.746075 0.127 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.746075 0.127 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.746075 0.127 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.746075 0.127 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.753822 0.123 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.760756 0.119 0 0
Signaling by FGFR2 R-HSA-5654738 0.760756 0.119 0 0
DAP12 signaling R-HSA-2424491 0.762806 0.118 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.762806 0.118 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.762806 0.118 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.764599 0.117 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.764599 0.117 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.764599 0.117 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.764599 0.117 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 0.764599 0.117 0 0
Arachidonate production from DAG R-HSA-426048 0.764599 0.117 0 0
Pexophagy R-HSA-9664873 0.764599 0.117 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.764599 0.117 0 0
Sperm Motility And Taxes R-HSA-1300642 0.764599 0.117 0 0
Regulation of the apoptosome activity R-HSA-9627069 0.764599 0.117 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.764599 0.117 0 0
Regulation of CDH11 function R-HSA-9762292 0.764599 0.117 0 0
Formation of apoptosome R-HSA-111458 0.764599 0.117 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.765826 0.116 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.765826 0.116 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.765826 0.116 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.765826 0.116 0 0
Nephrin family interactions R-HSA-373753 0.765826 0.116 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.765874 0.116 0 0
Gene Silencing by RNA R-HSA-211000 0.768953 0.114 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.771284 0.113 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.773743 0.111 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.777666 0.109 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.779521 0.108 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.779760 0.108 0 0
Apoptosis R-HSA-109581 0.781659 0.107 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.784336 0.105 0 0
Lagging Strand Synthesis R-HSA-69186 0.784336 0.105 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.784336 0.105 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.784336 0.105 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.784336 0.105 0 0
Signalling to RAS R-HSA-167044 0.784336 0.105 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.784423 0.105 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.789397 0.103 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 0.789397 0.103 0 0
Formation of the posterior neural plate R-HSA-9832991 0.789397 0.103 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.789397 0.103 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 0.789397 0.103 0 0
Bicarbonate transporters R-HSA-425381 0.789397 0.103 0 0
Transport of RCbl within the body R-HSA-9758890 0.789397 0.103 0 0
Suppression of apoptosis R-HSA-9635465 0.789397 0.103 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.791263 0.102 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.792986 0.101 0 0
DNA strand elongation R-HSA-69190 0.793575 0.100 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.793575 0.100 0 0
Ca2+ pathway R-HSA-4086398 0.794721 0.100 0 0
mRNA 3'-end processing R-HSA-72187 0.795587 0.099 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.800763 0.096 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.801547 0.096 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.801547 0.096 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.801547 0.096 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 0.801547 0.096 0 0
Glutathione synthesis and recycling R-HSA-174403 0.801547 0.096 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.801547 0.096 0 0
Assembly Of The HIV Virion R-HSA-175474 0.801547 0.096 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.804667 0.094 0 0
Ca-dependent events R-HSA-111996 0.805565 0.094 0 0
Meiotic synapsis R-HSA-1221632 0.806955 0.093 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.807668 0.093 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.807668 0.093 0 0
Autophagy R-HSA-9612973 0.808712 0.092 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 0.811583 0.091 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 0.811583 0.091 0 0
NF-kB is activated and signals survival R-HSA-209560 0.811583 0.091 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.811583 0.091 0 0
Plasmalogen biosynthesis R-HSA-75896 0.811583 0.091 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 0.811583 0.091 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 0.811583 0.091 0 0
DS-GAG biosynthesis R-HSA-2022923 0.811583 0.091 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 0.811583 0.091 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.814193 0.089 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.816903 0.088 0 0
Signaling by FGFR4 R-HSA-5654743 0.817515 0.088 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 0.817527 0.087 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.817527 0.087 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.817527 0.087 0 0
mTORC1-mediated signalling R-HSA-166208 0.817527 0.087 0 0
Cellular response to hypoxia R-HSA-1234174 0.820058 0.086 0 0
Striated Muscle Contraction R-HSA-390522 0.820940 0.086 0 0
S Phase R-HSA-69242 0.822035 0.085 0 0
RSV-host interactions R-HSA-9833110 0.828555 0.082 1 1
Amine ligand-binding receptors R-HSA-375280 0.828855 0.082 0 0
HIV Infection R-HSA-162906 0.830060 0.081 0 0
IRAK1 recruits IKK complex R-HSA-937039 0.831434 0.080 0 0
Maple Syrup Urine Disease R-HSA-9865114 0.831434 0.080 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 0.831434 0.080 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.831434 0.080 0 0
Regulation of IFNG signaling R-HSA-877312 0.831434 0.080 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 0.831434 0.080 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.831434 0.080 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 0.831434 0.080 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 0.831434 0.080 0 0
OAS antiviral response R-HSA-8983711 0.831434 0.080 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.832343 0.080 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.832343 0.080 0 0
Carnitine shuttle R-HSA-200425 0.832343 0.080 0 0
Formation of the ureteric bud R-HSA-9830674 0.832343 0.080 0 0
Signaling by NOTCH2 R-HSA-1980145 0.833423 0.079 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.833423 0.079 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.833423 0.079 0 0
Cell-Cell communication R-HSA-1500931 0.833940 0.079 0 0
Macroautophagy R-HSA-1632852 0.835630 0.078 0 0
Signaling by FGFR3 R-HSA-5654741 0.839602 0.076 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.840505 0.075 0 0
Signaling by WNT R-HSA-195721 0.840759 0.075 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.845149 0.073 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.845149 0.073 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.845149 0.073 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.846064 0.073 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.846064 0.073 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.846064 0.073 0 0
Telomere Maintenance R-HSA-157579 0.846632 0.072 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 0.849195 0.071 0 0
Adenylate cyclase activating pathway R-HSA-170660 0.849195 0.071 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.849195 0.071 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.849195 0.071 0 0
CD28 dependent Vav1 pathway R-HSA-389359 0.849195 0.071 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.849195 0.071 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 0.849195 0.071 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 0.849195 0.071 0 0
Processing of SMDT1 R-HSA-8949664 0.849195 0.071 0 0
Maturation of nucleoprotein R-HSA-9683610 0.849195 0.071 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 0.849195 0.071 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.849776 0.071 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.856152 0.067 0 0
Calmodulin induced events R-HSA-111933 0.856152 0.067 0 0
CaM pathway R-HSA-111997 0.856152 0.067 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.856590 0.067 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.856842 0.067 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.858757 0.066 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.858757 0.066 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.858757 0.066 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.858757 0.066 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.859399 0.066 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.859399 0.066 0 0
Recycling pathway of L1 R-HSA-437239 0.859399 0.066 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.863744 0.064 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.863744 0.064 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.863744 0.064 0 0
Extension of Telomeres R-HSA-180786 0.864923 0.063 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 0.865085 0.063 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.865085 0.063 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 0.865085 0.063 0 0
Hydrolysis of LPC R-HSA-1483115 0.865085 0.063 0 0
Physiological factors R-HSA-5578768 0.865085 0.063 0 0
HDL assembly R-HSA-8963896 0.865085 0.063 0 0
Acyl chain remodeling of CL R-HSA-1482798 0.865085 0.063 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 0.865085 0.063 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.866464 0.062 0 0
Cleavage of the damaged purine R-HSA-110331 0.866464 0.062 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.870484 0.060 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.870484 0.060 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.870484 0.060 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.870484 0.060 0 0
Metalloprotease DUBs R-HSA-5689901 0.870484 0.060 0 0
MET activates PTK2 signaling R-HSA-8874081 0.870484 0.060 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.870484 0.060 0 0
Glutathione conjugation R-HSA-156590 0.873002 0.059 0 0
Vesicle-mediated transport R-HSA-5653656 0.874951 0.058 0 0
Depurination R-HSA-73927 0.876119 0.057 0 0
Biofilm formation R-HSA-9931953 0.876119 0.057 0 0
Signaling by Insulin receptor R-HSA-74752 0.878483 0.056 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.878572 0.056 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.879301 0.056 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.879301 0.056 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 0.879301 0.056 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.879301 0.056 0 0
Translesion synthesis by REV1 R-HSA-110312 0.879301 0.056 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.879301 0.056 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 0.879301 0.056 0 0
Protein lipoylation R-HSA-9857492 0.879301 0.056 0 0
p38MAPK events R-HSA-171007 0.879301 0.056 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 0.879301 0.056 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.879301 0.056 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.879301 0.056 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.879301 0.056 0 0
Cristae formation R-HSA-8949613 0.881310 0.055 0 0
Packaging Of Telomere Ends R-HSA-171306 0.881310 0.055 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.881310 0.055 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.881310 0.055 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.881310 0.055 0 0
Adherens junctions interactions R-HSA-418990 0.881775 0.055 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.883277 0.054 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.885149 0.053 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.885149 0.053 0 0
Collagen formation R-HSA-1474290 0.890572 0.050 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.890767 0.050 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.891116 0.050 0 0
tRNA processing R-HSA-72306 0.891139 0.050 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.891293 0.050 0 0
Telomere Extension By Telomerase R-HSA-171319 0.891293 0.050 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.891293 0.050 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.891293 0.050 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.891293 0.050 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.891293 0.050 0 0
Signaling by NOTCH4 R-HSA-9013694 0.892019 0.050 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.892020 0.050 0 0
Translesion synthesis by POLI R-HSA-5656121 0.892020 0.050 0 0
Phosphorylation of the APC/C R-HSA-176412 0.892020 0.050 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.892020 0.050 0 0
Phase 4 - resting membrane potential R-HSA-5576886 0.892020 0.050 0 0
Fructose catabolism R-HSA-70350 0.892020 0.050 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.892020 0.050 0 0
Activation of SMO R-HSA-5635838 0.892020 0.050 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.892785 0.049 0 0
HSF1-dependent transactivation R-HSA-3371571 0.892785 0.049 0 0
Meiotic recombination R-HSA-912446 0.892785 0.049 0 0
Attenuation phase R-HSA-3371568 0.893586 0.049 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.893586 0.049 0 0
HIV Transcription Elongation R-HSA-167169 0.893586 0.049 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.893586 0.049 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.894878 0.048 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.895336 0.048 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.899574 0.046 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.899961 0.046 0 0
Platelet calcium homeostasis R-HSA-418360 0.900491 0.046 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.900491 0.046 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.900491 0.046 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.901463 0.045 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.901661 0.045 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.903400 0.044 0 0
Translesion synthesis by POLK R-HSA-5655862 0.903400 0.044 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 0.903400 0.044 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.903400 0.044 0 0
Scavenging by Class B Receptors R-HSA-3000471 0.903400 0.044 0 0
Synthesis of PG R-HSA-1483148 0.903400 0.044 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 0.903400 0.044 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.903588 0.044 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.903588 0.044 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.904176 0.044 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.905967 0.043 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.906709 0.043 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.906709 0.043 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.906709 0.043 0 0
Smooth Muscle Contraction R-HSA-445355 0.906709 0.043 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.908958 0.041 0 0
Programmed Cell Death R-HSA-5357801 0.910284 0.041 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.911567 0.040 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.913050 0.040 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.913581 0.039 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.913581 0.039 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.913581 0.039 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.913581 0.039 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.913581 0.039 0 0
Catecholamine biosynthesis R-HSA-209905 0.913581 0.039 0 0
Sulfide oxidation to sulfate R-HSA-1614517 0.913581 0.039 0 0
Glycogen storage diseases R-HSA-3229121 0.913581 0.039 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.913581 0.039 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 0.913581 0.039 0 0
RNA Polymerase I Transcription R-HSA-73864 0.915134 0.039 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.915655 0.038 0 0
Depyrimidination R-HSA-73928 0.915655 0.038 0 0
Signaling by FGFR R-HSA-190236 0.916458 0.038 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.916458 0.038 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.916458 0.038 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.916458 0.038 0 0
Trafficking of AMPA receptors R-HSA-399719 0.916746 0.038 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.916746 0.038 0 0
Cargo concentration in the ER R-HSA-5694530 0.916746 0.038 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.919004 0.037 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.920192 0.036 0 0
Defective pyroptosis R-HSA-9710421 0.922029 0.035 0 0
Base Excision Repair R-HSA-73884 0.922464 0.035 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.922689 0.035 0 0
Nephron development R-HSA-9831926 0.922689 0.035 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.922689 0.035 0 0
PKA activation in glucagon signalling R-HSA-164378 0.922689 0.035 0 0
Apoptotic factor-mediated response R-HSA-111471 0.922689 0.035 0 0
PKA activation R-HSA-163615 0.922689 0.035 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.922689 0.035 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.923999 0.034 0 0
Regulated Necrosis R-HSA-5218859 0.923999 0.034 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.924328 0.034 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.924328 0.034 0 0
Signaling by FGFR1 R-HSA-5654736 0.924590 0.034 0 0
Glycolysis R-HSA-70171 0.925238 0.034 0 0
DAP12 interactions R-HSA-2172127 0.927960 0.032 0 0
Synthesis of PA R-HSA-1483166 0.929826 0.032 0 0
G-protein beta:gamma signalling R-HSA-397795 0.930480 0.031 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.930480 0.031 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.930480 0.031 0 0
Integrin signaling R-HSA-354192 0.930480 0.031 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.930667 0.031 0 0
Translesion Synthesis by POLH R-HSA-110320 0.930838 0.031 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.930838 0.031 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.930838 0.031 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.930838 0.031 0 0
Diseases of hemostasis R-HSA-9671793 0.930838 0.031 0 0
Maturation of nucleoprotein R-HSA-9694631 0.930838 0.031 0 0
The NLRP3 inflammasome R-HSA-844456 0.930838 0.031 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 0.930838 0.031 0 0
Potential therapeutics for SARS R-HSA-9679191 0.931816 0.031 0 0
Phospholipid metabolism R-HSA-1483257 0.932187 0.030 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.933473 0.030 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.933473 0.030 0 0
DAG and IP3 signaling R-HSA-1489509 0.933473 0.030 0 0
Signaling by Interleukins R-HSA-449147 0.934730 0.029 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.934732 0.029 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.936515 0.028 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.936515 0.028 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.937837 0.028 0 0
ECM proteoglycans R-HSA-3000178 0.937837 0.028 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.937838 0.028 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.937984 0.028 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.938129 0.028 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 0.938129 0.028 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 0.938129 0.028 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 0.938129 0.028 0 0
Acyl chain remodelling of PI R-HSA-1482922 0.938129 0.028 0 0
Glycogen synthesis R-HSA-3322077 0.938129 0.028 0 0
Pregnenolone biosynthesis R-HSA-196108 0.938129 0.028 0 0
Synthesis of Ketone Bodies R-HSA-77111 0.938129 0.028 0 0
Signal transduction by L1 R-HSA-445144 0.938129 0.028 0 0
mRNA Splicing R-HSA-72172 0.938822 0.027 0 0
Host Interactions of HIV factors R-HSA-162909 0.941447 0.026 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.941713 0.026 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.941921 0.026 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.942051 0.026 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.942051 0.026 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.942051 0.026 0 0
HCMV Early Events R-HSA-9609690 0.942989 0.025 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.944651 0.025 0 0
ERK/MAPK targets R-HSA-198753 0.944651 0.025 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 0.944651 0.025 0 0
Acyl chain remodelling of PG R-HSA-1482925 0.944651 0.025 0 0
Basigin interactions R-HSA-210991 0.944651 0.025 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.945760 0.024 0 0
Nucleotide Excision Repair R-HSA-5696398 0.946945 0.024 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.947126 0.024 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.947126 0.024 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.947639 0.023 0 0
PLC beta mediated events R-HSA-112043 0.947639 0.023 0 0
Co-stimulation by CD28 R-HSA-389356 0.947761 0.023 0 0
Metal ion SLC transporters R-HSA-425410 0.947761 0.023 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.948431 0.023 0 0
Cell-cell junction organization R-HSA-421270 0.949615 0.022 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.949963 0.022 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.950486 0.022 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.950486 0.022 0 0
Serine metabolism R-HSA-977347 0.950486 0.022 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.950486 0.022 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 0.950486 0.022 0 0
HSF1 activation R-HSA-3371511 0.951775 0.021 0 0
Glycosphingolipid transport R-HSA-9845576 0.951775 0.021 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.951775 0.021 0 0
Gap junction trafficking and regulation R-HSA-157858 0.951851 0.021 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.951851 0.021 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.951851 0.021 0 0
Co-inhibition by PD-1 R-HSA-389948 0.952203 0.021 0 0
Cellular response to starvation R-HSA-9711097 0.953693 0.021 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.954896 0.020 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.954896 0.020 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.955543 0.020 0 0
Stimuli-sensing channels R-HSA-2672351 0.955543 0.020 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.955706 0.020 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 0.955706 0.020 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.955706 0.020 0 0
Fructose metabolism R-HSA-5652084 0.955706 0.020 0 0
Ethanol oxidation R-HSA-71384 0.955706 0.020 0 0
Cellular hexose transport R-HSA-189200 0.955706 0.020 0 0
LDL clearance R-HSA-8964038 0.955706 0.020 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.956031 0.020 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.958119 0.019 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.959148 0.018 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.959927 0.018 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.959927 0.018 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.960376 0.018 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 0.960376 0.018 0 0
Mitochondrial mRNA modification R-HSA-9937008 0.960376 0.018 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.960376 0.018 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.960376 0.018 0 0
Ketone body metabolism R-HSA-74182 0.960376 0.018 0 0
Syndecan interactions R-HSA-3000170 0.960376 0.018 0 0
Integrin cell surface interactions R-HSA-216083 0.961722 0.017 0 0
Orc1 removal from chromatin R-HSA-68949 0.962394 0.017 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.962394 0.017 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.962394 0.017 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.962394 0.017 0 0
Neurotransmitter release cycle R-HSA-112310 0.963136 0.016 0 0
Stabilization of p53 R-HSA-69541 0.963490 0.016 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.963490 0.016 0 0
Interleukin-1 family signaling R-HSA-446652 0.964496 0.016 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 0.964554 0.016 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.964554 0.016 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.964554 0.016 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.964554 0.016 0 0
Plasma lipoprotein assembly R-HSA-8963898 0.964554 0.016 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.965397 0.015 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.965397 0.015 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.965602 0.015 0 0
G-protein mediated events R-HSA-112040 0.966705 0.015 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.966748 0.015 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.966748 0.015 0 0
Generation of second messenger molecules R-HSA-202433 0.966748 0.015 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.967135 0.015 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 0.968292 0.014 0 0
G protein gated Potassium channels R-HSA-1296059 0.968292 0.014 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 0.968292 0.014 0 0
Tight junction interactions R-HSA-420029 0.968292 0.014 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 0.968292 0.014 0 0
Hyaluronan degradation R-HSA-2160916 0.968292 0.014 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.968292 0.014 0 0
Fertilization R-HSA-1187000 0.968292 0.014 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.969095 0.014 0 0
Developmental Cell Lineages R-HSA-9734767 0.969335 0.014 0 0
EPH-Ephrin signaling R-HSA-2682334 0.969888 0.013 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.970736 0.013 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.971250 0.013 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 0.971636 0.012 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.971636 0.012 0 0
Urea cycle R-HSA-70635 0.971636 0.012 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 0.971636 0.012 0 0
Sphingolipid catabolism R-HSA-9845614 0.971636 0.012 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.971636 0.012 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.972444 0.012 0 0
Heme biosynthesis R-HSA-189451 0.972444 0.012 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.972444 0.012 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.972699 0.012 0 0
Signaling by VEGF R-HSA-194138 0.972769 0.012 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.973104 0.012 0 0
Influenza Infection R-HSA-168255 0.973185 0.012 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 0.974627 0.011 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 0.974627 0.011 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.974627 0.011 0 0
Synthesis of PE R-HSA-1483213 0.974627 0.011 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 0.974627 0.011 0 0
Insulin processing R-HSA-264876 0.974627 0.011 0 0
Activation of GABAB receptors R-HSA-991365 0.974926 0.011 0 0
GABA B receptor activation R-HSA-977444 0.974926 0.011 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.974926 0.011 0 0
Dectin-2 family R-HSA-5621480 0.975289 0.011 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.975579 0.011 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.975579 0.011 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.976051 0.011 1 0
Platelet homeostasis R-HSA-418346 0.976302 0.010 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.976424 0.010 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.977303 0.010 0 0
Pyroptosis R-HSA-5620971 0.977303 0.010 0 0
Inflammasomes R-HSA-622312 0.977303 0.010 0 0
Dual incision in TC-NER R-HSA-6782135 0.977305 0.010 0 0
Glucose metabolism R-HSA-70326 0.977391 0.010 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.979132 0.009 0 0
Gap junction trafficking R-HSA-190828 0.979259 0.009 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.979259 0.009 0 0
DNA methylation R-HSA-5334118 0.979697 0.009 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 0.979697 0.009 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.980094 0.009 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.980094 0.009 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.980876 0.008 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.980876 0.008 0 0
Cellular responses to stress R-HSA-2262752 0.980921 0.008 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.981143 0.008 0 0
Interleukin-12 family signaling R-HSA-447115 0.981495 0.008 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.981495 0.008 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.981839 0.008 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.981839 0.008 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.982861 0.008 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.982861 0.008 0 0
Interferon Signaling R-HSA-913531 0.982895 0.007 0 0
Interleukin-12 signaling R-HSA-9020591 0.983560 0.007 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.983594 0.007 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.983594 0.007 0 0
EGFR downregulation R-HSA-182971 0.983754 0.007 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.983754 0.007 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.984427 0.007 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.984427 0.007 0 0
Synthesis of PC R-HSA-1483191 0.984427 0.007 0 0
Cellular response to chemical stress R-HSA-9711123 0.984964 0.007 0 0
Inwardly rectifying K+ channels R-HSA-1296065 0.985468 0.006 0 0
Intraflagellar transport R-HSA-5620924 0.985853 0.006 0 0
HCMV Late Events R-HSA-9610379 0.986004 0.006 0 0
Signaling by ROBO receptors R-HSA-376176 0.986133 0.006 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.987001 0.006 0 0
Defective B3GALTL causes PpS R-HSA-5083635 0.987001 0.006 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.987001 0.006 0 0
Recycling of bile acids and salts R-HSA-159418 0.987001 0.006 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.987606 0.005 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.987619 0.005 0 0
HCMV Infection R-HSA-9609646 0.987795 0.005 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.987828 0.005 0 0
Integration of energy metabolism R-HSA-163685 0.987828 0.005 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.987923 0.005 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.988093 0.005 0 0
Protein folding R-HSA-391251 0.988236 0.005 0 0
Azathioprine ADME R-HSA-9748787 0.988334 0.005 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.988373 0.005 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.988373 0.005 0 0
Heme degradation R-HSA-189483 0.988373 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 0.988373 0.005 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.988646 0.005 0 0
Dual Incision in GG-NER R-HSA-5696400 0.989599 0.005 0 0
eNOS activation R-HSA-203615 0.989599 0.005 0 0
Gap junction assembly R-HSA-190861 0.989599 0.005 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.989599 0.005 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.989599 0.005 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.989599 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 0.989599 0.005 0 0
Mitophagy R-HSA-5205647 0.989599 0.005 0 0
RA biosynthesis pathway R-HSA-5365859 0.989599 0.005 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.989599 0.005 0 0
Signal amplification R-HSA-392518 0.989599 0.005 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.989599 0.005 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.990388 0.004 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.990388 0.004 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.990388 0.004 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.990423 0.004 0 0
O-linked glycosylation of mucins R-HSA-913709 0.990479 0.004 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.990659 0.004 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.990659 0.004 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.990966 0.004 0 0
Synthesis of DNA R-HSA-69239 0.990981 0.004 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.991278 0.004 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.991278 0.004 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.992026 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.992026 0.003 0 0
Translation initiation complex formation R-HSA-72649 0.992088 0.003 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.992088 0.003 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.992220 0.003 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.992351 0.003 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.992557 0.003 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 0.992557 0.003 0 0
Voltage gated Potassium channels R-HSA-1296072 0.992557 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 0.992557 0.003 0 0
Metabolism of porphyrins R-HSA-189445 0.992705 0.003 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.993308 0.003 0 0
tRNA processing in the mitochondrion R-HSA-6785470 0.993342 0.003 0 0
Elastic fibre formation R-HSA-1566948 0.993342 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 0.993342 0.003 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.993492 0.003 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.993492 0.003 0 0
Ion homeostasis R-HSA-5578775 0.993492 0.003 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.993780 0.003 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.993780 0.003 0 0
Peptide chain elongation R-HSA-156902 0.994338 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.994423 0.002 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.994652 0.002 0 0
Cellular responses to stimuli R-HSA-8953897 0.994658 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 0.994673 0.002 0 0
Glycogen metabolism R-HSA-8982491 0.994673 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 0.994673 0.002 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.994903 0.002 0 0
Protein ubiquitination R-HSA-8852135 0.994903 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.995039 0.002 0 0
Peroxisomal protein import R-HSA-9033241 0.995153 0.002 0 0
Neddylation R-HSA-8951664 0.995164 0.002 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.995236 0.002 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.995236 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 0.995236 0.002 0 0
Maturation of spike protein R-HSA-9694548 0.995236 0.002 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.995602 0.002 0 0
GABA receptor activation R-HSA-977443 0.995608 0.002 0 0
Intra-Golgi traffic R-HSA-6811438 0.995739 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 0.995739 0.002 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.995750 0.002 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.995770 0.002 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.995814 0.002 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.995959 0.002 0 0
IRE1alpha activates chaperones R-HSA-381070 0.995959 0.002 0 0
Endogenous sterols R-HSA-211976 0.996021 0.002 0 0
Leishmania phagocytosis R-HSA-9664417 0.996058 0.002 0 0
Parasite infection R-HSA-9664407 0.996058 0.002 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.996058 0.002 0 0
PCP/CE pathway R-HSA-4086400 0.996115 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 0.996115 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.996188 0.002 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.996289 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.996289 0.002 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.996328 0.002 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.996395 0.002 0 0
Mitochondrial protein import R-HSA-1268020 0.996395 0.002 0 0
Metabolism of RNA R-HSA-8953854 0.996589 0.001 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.996591 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 0.996591 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.996591 0.001 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.996592 0.001 0 0
Complex I biogenesis R-HSA-6799198 0.996735 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 0.996871 0.001 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.996921 0.001 0 0
Surfactant metabolism R-HSA-5683826 0.996951 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 0.996951 0.001 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.997044 0.001 0 0
Amyloid fiber formation R-HSA-977225 0.997045 0.001 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.997161 0.001 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.997161 0.001 0 0
Somitogenesis R-HSA-9824272 0.997273 0.001 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.997273 0.001 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.997273 0.001 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.997273 0.001 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.997273 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 0.997273 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 0.997273 0.001 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.997364 0.001 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.997364 0.001 0 0
Eukaryotic Translation Termination R-HSA-72764 0.997364 0.001 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.997561 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.997561 0.001 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.997561 0.001 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.997561 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 0.997818 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 0.997818 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.997966 0.001 0 0
GPER1 signaling R-HSA-9634597 0.998049 0.001 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.998099 0.001 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.998138 0.001 0 0
Interleukin-1 signaling R-HSA-9020702 0.998433 0.001 0 0
Selenocysteine synthesis R-HSA-2408557 0.998433 0.001 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.998433 0.001 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.998439 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 0.998439 0.001 0 0
Platelet degranulation R-HSA-114608 0.998451 0.001 0 0
Toll-like Receptor Cascades R-HSA-168898 0.998483 0.001 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.998563 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 0.998604 0.001 0 0
Complex IV assembly R-HSA-9864848 0.998604 0.001 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.998671 0.001 0 0
Viral mRNA Translation R-HSA-192823 0.998685 0.001 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.998751 0.001 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.998755 0.001 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.998755 0.001 0 0
Opioid Signalling R-HSA-111885 0.998795 0.001 0 0
SARS-CoV Infections R-HSA-9679506 0.998825 0.001 0 0
Downstream TCR signaling R-HSA-202424 0.998828 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 0.998883 0.000 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.999001 0.000 0 0
Iron uptake and transport R-HSA-917937 0.999017 0.000 0 0
Interferon gamma signaling R-HSA-877300 0.999083 0.000 0 0
G alpha (z) signalling events R-HSA-418597 0.999107 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 0.999107 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.999115 0.000 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.999116 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.999194 0.000 0 0
Translation of Structural Proteins R-HSA-9694635 0.999197 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 0.999201 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.999201 0.000 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.999224 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 0.999274 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.999333 0.000 0 0
TCR signaling R-HSA-202403 0.999352 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.999361 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999411 0.000 0 0
Potassium Channels R-HSA-1296071 0.999448 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 0.999457 0.000 0 0
Signaling by Hedgehog R-HSA-5358351 0.999457 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.999458 0.000 0 0
rRNA processing R-HSA-72312 0.999485 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 0.999489 0.000 0 0
Metabolism of polyamines R-HSA-351202 0.999489 0.000 0 0
tRNA Aminoacylation R-HSA-379724 0.999489 0.000 0 0
SLC transporter disorders R-HSA-5619102 0.999500 0.000 0 0
Protein localization R-HSA-9609507 0.999512 0.000 0 0
Aquaporin-mediated transport R-HSA-445717 0.999543 0.000 0 0
Regulation of insulin secretion R-HSA-422356 0.999543 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.999563 0.000 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.999591 0.000 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.999593 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999599 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 0.999605 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 0.999622 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.999654 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.999660 0.000 0 0
Muscle contraction R-HSA-397014 0.999671 0.000 0 0
Ion transport by P-type ATPases R-HSA-936837 0.999673 0.000 0 0
Xenobiotics R-HSA-211981 0.999673 0.000 0 0
Ion channel transport R-HSA-983712 0.999746 0.000 0 0
Nicotinate metabolism R-HSA-196807 0.999766 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 0.999766 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 0.999766 0.000 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.999844 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 0.999848 0.000 0 0
Metabolism of cofactors R-HSA-8978934 0.999850 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 0.999850 0.000 0 0
Hedgehog 'on' state R-HSA-5632684 0.999850 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 0.999855 0.000 0 0
DNA Replication R-HSA-69306 0.999857 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 0.999880 0.000 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.999900 0.000 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.999906 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 0.999911 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.999915 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 0.999915 0.000 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.999915 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 0.999931 0.000 0 0
ABC transporter disorders R-HSA-5619084 0.999932 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 0.999933 0.000 0 0
Cardiac conduction R-HSA-5576891 0.999934 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 0.999939 0.000 0 0
Hedgehog 'off' state R-HSA-5610787 0.999944 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999945 0.000 0 0
Extracellular matrix organization R-HSA-1474244 0.999947 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.999951 0.000 0 0
O-linked glycosylation R-HSA-5173105 0.999966 0.000 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.999972 0.000 0 0
G alpha (s) signalling events R-HSA-418555 0.999972 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 0.999975 0.000 0 0
Neuronal System R-HSA-112316 0.999975 0.000 0 0
Pyruvate metabolism R-HSA-70268 0.999978 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.999984 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 0.999984 0.000 0 0
Leishmania infection R-HSA-9658195 0.999984 0.000 0 0
Diseases of glycosylation R-HSA-3781865 0.999991 0.000 0 0
Hemostasis R-HSA-109582 0.999992 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.999993 0.000 0 0
Mitochondrial translation R-HSA-5368287 0.999995 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.999995 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.999997 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 0.999998 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.999998 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.999998 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 0.999999 0.000 0 0
Adaptive Immune System R-HSA-1280218 0.999999 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.999999 0.000 0 0
Arachidonate metabolism R-HSA-2142753 0.999999 0.000 0 0
Antimicrobial peptides R-HSA-6803157 0.999999 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.999999 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 1.000000 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 1.000000 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000 0.000 0 0
Viral Infection Pathways R-HSA-9824446 1.000000 0.000 1 0
Keratinization R-HSA-6805567 1.000000 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000 0.000 0 0
G alpha (q) signalling events R-HSA-416476 1.000000 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 1.000000 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 1.000000 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000 0.000 0 0
Drug ADME R-HSA-9748784 1.000000 0.000 0 0
Neutrophil degranulation R-HSA-6798695 1.000000 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
Translation R-HSA-72766 1.000000 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000 0.000 0 0
Disease R-HSA-1643685 1.000000 0.000 1 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
Immune System R-HSA-168256 1.000000 0.000 0 0
Infectious disease R-HSA-5663205 1.000000 0.000 1 0
Metabolism of proteins R-HSA-392499 1.000000 -0.000 0 0
Innate Immune System R-HSA-168249 1.000000 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 -0.000 1 0
Olfactory Signaling Pathway R-HSA-381753 1.000000 -0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 1 0
GPCR ligand binding R-HSA-500792 1.000000 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 7.968948e-09 8.099 0 0
Cellular response to heat stress R-HSA-3371556 1.121231e-07 6.950 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.000184e-07 6.699 0 0
HSF1-dependent transactivation R-HSA-3371571 3.289765e-07 6.483 0 0
Attenuation phase R-HSA-3371568 6.330165e-07 6.199 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.143274e-06 5.942 0 0
mRNA Splicing R-HSA-72172 1.939312e-06 5.712 0 0
Mitotic Prometaphase R-HSA-68877 2.282938e-06 5.642 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.498083e-06 5.347 0 0
M Phase R-HSA-68886 4.503618e-06 5.346 0 0
Cell Cycle, Mitotic R-HSA-69278 4.864116e-06 5.313 0 0
Mitotic Anaphase R-HSA-68882 7.511981e-06 5.124 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.545559e-06 5.068 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.361210e-06 5.078 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.051636e-05 4.978 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.214227e-05 4.916 0 0
HSF1 activation R-HSA-3371511 1.292330e-05 4.889 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.701487e-05 4.769 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.638888e-05 4.785 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.387539e-05 4.622 0 0
Cell Cycle Checkpoints R-HSA-69620 5.595833e-05 4.252 0 0
Apoptotic execution phase R-HSA-75153 5.565442e-05 4.255 0 0
Cellular responses to stress R-HSA-2262752 7.441698e-05 4.128 0 0
Separation of Sister Chromatids R-HSA-2467813 7.962296e-05 4.099 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 7.867688e-05 4.104 1 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.139158e-05 4.089 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.380496e-04 3.860 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.380496e-04 3.860 0 0
Cellular responses to stimuli R-HSA-8953897 1.984482e-04 3.702 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.963258e-04 3.528 0 0
Signal Transduction R-HSA-162582 3.046648e-04 3.516 1 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.391032e-04 3.470 0 0
Metabolism of RNA R-HSA-8953854 3.790335e-04 3.421 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.182011e-04 3.379 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.246700e-04 3.204 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.749157e-04 3.171 0 0
Signaling by ALK in cancer R-HSA-9700206 6.749157e-04 3.171 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.222359e-04 3.085 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.016861e-03 2.993 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.157355e-03 2.937 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.477566e-03 2.830 0 0
Cellular Senescence R-HSA-2559583 1.527940e-03 2.816 0 0
G alpha (12/13) signalling events R-HSA-416482 1.615362e-03 2.792 0 0
Chromatin organization R-HSA-4839726 1.690839e-03 2.772 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.803617e-03 2.744 0 0
Gene expression (Transcription) R-HSA-74160 1.906360e-03 2.720 1 0
Signaling by Hippo R-HSA-2028269 2.094898e-03 2.679 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.175216e-03 2.662 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.340522e-03 2.631 0 0
Membrane Trafficking R-HSA-199991 2.283869e-03 2.641 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.446040e-03 2.612 0 0
Ephrin signaling R-HSA-3928664 2.740792e-03 2.562 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.197230e-03 2.495 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 3.481054e-03 2.458 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.630324e-03 2.440 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.772551e-03 2.423 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.343836e-03 2.476 0 0
Nuclear import of Rev protein R-HSA-180746 3.646934e-03 2.438 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.571940e-03 2.447 0 0
Cell-Cell communication R-HSA-1500931 3.452636e-03 2.462 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.630324e-03 2.440 0 0
Apoptosis R-HSA-109581 3.689263e-03 2.433 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.884770e-03 2.411 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.884770e-03 2.411 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.123421e-03 2.385 0 0
Metabolism of non-coding RNA R-HSA-194441 4.199476e-03 2.377 0 0
snRNP Assembly R-HSA-191859 4.199476e-03 2.377 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.279614e-03 2.369 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.408433e-03 2.356 0 0
HIV Life Cycle R-HSA-162587 4.505890e-03 2.346 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.669517e-03 2.331 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.711206e-03 2.327 0 0
Nucleotide Excision Repair R-HSA-5696398 5.015267e-03 2.300 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.132520e-03 2.290 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.132520e-03 2.290 0 0
Chromatin modifying enzymes R-HSA-3247509 4.959291e-03 2.305 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.162511e-03 2.287 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.960153e-03 2.225 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 5.960153e-03 2.225 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.060188e-03 2.218 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.073145e-03 2.217 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.073145e-03 2.217 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.664089e-03 2.247 0 0
Programmed Cell Death R-HSA-5357801 5.849951e-03 2.233 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.898040e-03 2.229 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.406405e-03 2.193 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.971032e-03 2.157 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.971032e-03 2.157 0 0
Deubiquitination R-HSA-5688426 6.717316e-03 2.173 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.992734e-03 2.155 0 0
NRAGE signals death through JNK R-HSA-193648 6.727300e-03 2.172 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.110034e-03 2.148 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.326040e-03 2.135 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.327651e-03 2.135 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 7.327651e-03 2.135 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.293480e-03 2.081 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 8.153369e-03 2.089 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.293480e-03 2.081 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.371921e-03 2.077 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.371921e-03 2.077 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.410663e-03 2.075 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.508881e-03 2.070 0 0
HIV Infection R-HSA-162906 8.578138e-03 2.067 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.581747e-03 2.066 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.644280e-03 2.063 0 0
mRNA 3'-end processing R-HSA-72187 9.462594e-03 2.024 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.462594e-03 2.024 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 9.399735e-03 2.027 0 0
EPH-Ephrin signaling R-HSA-2682334 9.473992e-03 2.023 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.616706e-03 2.017 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.029313e-02 1.987 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.029313e-02 1.987 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.029313e-02 1.987 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 9.902610e-03 2.004 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 9.837463e-03 2.007 0 0
Signaling by RAS mutants R-HSA-6802949 1.029313e-02 1.987 0 0
Cell junction organization R-HSA-446728 9.769022e-03 2.010 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.616706e-03 2.017 0 0
Interleukin-12 family signaling R-HSA-447115 1.066556e-02 1.972 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.072612e-02 1.970 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.085424e-02 1.964 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.173140e-02 1.931 0 0
PTEN Regulation R-HSA-6807070 1.078917e-02 1.967 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.109679e-02 1.955 0 0
Josephin domain DUBs R-HSA-5689877 1.109717e-02 1.955 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.100558e-02 1.958 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.100558e-02 1.958 0 0
Death Receptor Signaling R-HSA-73887 1.119458e-02 1.951 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.109679e-02 1.955 0 0
Glycolysis R-HSA-70171 1.104731e-02 1.957 0 0
Centrosome maturation R-HSA-380287 1.220316e-02 1.914 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.229315e-02 1.910 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.234871e-02 1.908 0 0
Macroautophagy R-HSA-1632852 1.247872e-02 1.904 0 0
MAP2K and MAPK activation R-HSA-5674135 1.274501e-02 1.895 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.274501e-02 1.895 0 0
Adherens junctions interactions R-HSA-418990 1.300587e-02 1.886 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.448927e-02 1.839 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.448927e-02 1.839 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.411515e-02 1.850 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.392353e-02 1.856 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.454146e-02 1.837 0 0
tRNA processing in the nucleus R-HSA-6784531 1.374494e-02 1.862 0 0
Interleukin-12 signaling R-HSA-9020591 1.350060e-02 1.870 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.478991e-02 1.830 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.482380e-02 1.829 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.488906e-02 1.827 0 0
L1CAM interactions R-HSA-373760 1.533627e-02 1.814 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.540611e-02 1.812 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.554111e-02 1.809 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.787646e-02 1.748 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.787646e-02 1.748 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.787646e-02 1.748 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.787646e-02 1.748 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.787646e-02 1.748 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.787646e-02 1.748 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.787646e-02 1.748 0 0
Regulation of TP53 Activity R-HSA-5633007 1.673002e-02 1.777 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.776378e-02 1.750 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.689170e-02 1.772 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.736591e-02 1.760 1 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.713376e-02 1.766 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.811592e-02 1.742 0 0
Interferon Signaling R-HSA-913531 1.856248e-02 1.731 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.963081e-02 1.707 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.963081e-02 1.707 0 0
Activation of RAC1 R-HSA-428540 1.930670e-02 1.714 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.134580e-02 1.671 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.134580e-02 1.671 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.080967e-02 1.682 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.957274e-02 1.708 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.126174e-02 1.672 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.930670e-02 1.714 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.134580e-02 1.671 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.979530e-02 1.703 0 0
DNA Repair R-HSA-73894 1.986217e-02 1.702 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.914167e-02 1.718 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.040577e-02 1.690 0 0
Autophagy R-HSA-9612973 2.151204e-02 1.667 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.155947e-02 1.666 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.254857e-02 1.647 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.350729e-02 1.629 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.350729e-02 1.629 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.358449e-02 1.627 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.358449e-02 1.627 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.374575e-02 1.624 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.388813e-02 1.622 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.428452e-02 1.615 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.434762e-02 1.614 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.458447e-02 1.609 0 0
Repression of WNT target genes R-HSA-4641265 2.459769e-02 1.609 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.459769e-02 1.609 0 0
mTORC1-mediated signalling R-HSA-166208 2.556924e-02 1.592 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.659534e-02 1.575 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.659534e-02 1.575 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.598521e-02 1.585 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.598521e-02 1.585 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.809997e-02 1.551 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.944583e-02 1.531 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.790098e-02 1.554 0 0
RNA Polymerase II Transcription R-HSA-73857 2.804260e-02 1.552 1 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.984089e-02 1.525 1 0
Signaling by FGFR1 in disease R-HSA-5655302 2.997034e-02 1.523 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.006058e-02 1.522 0 0
Cell-cell junction organization R-HSA-421270 3.050644e-02 1.516 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.054797e-02 1.515 0 0
Axon guidance R-HSA-422475 3.062391e-02 1.514 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.073929e-02 1.512 0 0
Formation of axial mesoderm R-HSA-9796292 3.073929e-02 1.512 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.073929e-02 1.512 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.124960e-02 1.505 0 0
Semaphorin interactions R-HSA-373755 3.167896e-02 1.499 0 0
Activation of BH3-only proteins R-HSA-114452 3.233631e-02 1.490 0 0
Signaling by EGFR R-HSA-177929 3.262152e-02 1.486 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.273304e-02 1.485 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.343107e-02 1.476 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.765745e-02 1.424 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.765745e-02 1.424 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.765745e-02 1.424 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.765745e-02 1.424 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.504970e-02 1.455 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.504970e-02 1.455 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.958386e-02 1.402 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.056842e-02 1.392 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.056842e-02 1.392 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.647549e-02 1.438 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.971388e-02 1.401 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.759794e-02 1.425 0 0
Regulation of CDH1 Function R-HSA-9764561 3.598357e-02 1.444 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.486554e-02 1.458 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.486554e-02 1.458 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.510756e-02 1.455 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.587851e-02 1.445 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.161134e-02 1.381 0 0
Selective autophagy R-HSA-9663891 4.185481e-02 1.378 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.187431e-02 1.378 0 0
Nervous system development R-HSA-9675108 4.190510e-02 1.378 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.289064e-02 1.368 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.375013e-02 1.359 0 0
Formation of definitive endoderm R-HSA-9823730 4.375013e-02 1.359 0 0
DNA Double Strand Break Response R-HSA-5693606 4.536068e-02 1.343 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.569517e-02 1.340 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.569517e-02 1.340 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.569517e-02 1.340 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.569517e-02 1.340 0 0
Host Interactions of HIV factors R-HSA-162909 4.581416e-02 1.339 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.661798e-02 1.331 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.661798e-02 1.331 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.661798e-02 1.331 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.759340e-02 1.322 0 0
G-protein beta:gamma signalling R-HSA-397795 4.759340e-02 1.322 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.865216e-02 1.313 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 4.865216e-02 1.313 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.865216e-02 1.313 0 0
Glucose metabolism R-HSA-70326 4.896562e-02 1.310 0 0
Phosphorylation of the APC/C R-HSA-176412 5.454491e-02 1.263 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.454491e-02 1.263 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.102194e-02 1.292 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.102194e-02 1.292 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.102194e-02 1.292 0 0
Prolonged ERK activation events R-HSA-169893 5.454491e-02 1.263 0 0
Homology Directed Repair R-HSA-5693538 5.207264e-02 1.283 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.898979e-02 1.229 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.311801e-02 1.275 0 0
RNA Polymerase I Transcription R-HSA-73864 5.899390e-02 1.229 0 0
G2/M Checkpoints R-HSA-69481 5.805929e-02 1.236 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.454491e-02 1.263 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.546098e-02 1.256 0 0
ESR-mediated signaling R-HSA-8939211 5.103402e-02 1.292 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.281710e-02 1.277 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.188140e-02 1.285 0 0
S Phase R-HSA-69242 5.565496e-02 1.254 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.898979e-02 1.229 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.139632e-02 1.289 0 0
HDACs deacetylate histones R-HSA-3214815 5.943237e-02 1.226 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.862536e-02 1.232 0 0
IRE1alpha activates chaperones R-HSA-381070 5.587967e-02 1.253 0 0
HIV elongation arrest and recovery R-HSA-167287 6.036804e-02 1.219 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.036804e-02 1.219 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.036804e-02 1.219 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.225807e-02 1.206 0 0
Regulation of TP53 Expression R-HSA-6804754 6.271471e-02 1.203 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 6.271471e-02 1.203 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.390190e-02 1.194 0 0
Disorders of Developmental Biology R-HSA-9675151 6.431646e-02 1.192 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.672315e-02 1.176 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.742550e-02 1.171 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.763327e-02 1.170 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.764065e-02 1.170 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.765831e-02 1.170 0 0
Late endosomal microautophagy R-HSA-9615710 6.808278e-02 1.167 0 0
PKR-mediated signaling R-HSA-9833482 6.822725e-02 1.166 0 0
MTOR signalling R-HSA-165159 7.143169e-02 1.146 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.198907e-02 1.143 0 0
G2/M Transition R-HSA-69275 7.203877e-02 1.142 0 0
FLT3 signaling in disease R-HSA-9682385 7.427455e-02 1.129 0 0
RET signaling R-HSA-8853659 7.427455e-02 1.129 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.464481e-02 1.127 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.500354e-02 1.125 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.636136e-02 1.117 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.636136e-02 1.117 0 0
Influenza Infection R-HSA-168255 7.721946e-02 1.112 0 0
Signaling by FGFR in disease R-HSA-1226099 7.826110e-02 1.106 0 0
TBC/RABGAPs R-HSA-8854214 7.843689e-02 1.105 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 8.227715e-02 1.085 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 8.227715e-02 1.085 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.227715e-02 1.085 0 0
EGFR downregulation R-HSA-182971 8.520275e-02 1.070 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.659111e-02 1.063 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.659111e-02 1.063 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.659111e-02 1.063 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.659111e-02 1.063 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.659111e-02 1.063 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.615945e-02 1.017 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.615945e-02 1.017 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.615945e-02 1.017 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 9.185185e-02 1.037 0 0
MET interacts with TNS proteins R-HSA-8875513 9.185185e-02 1.037 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 9.185185e-02 1.037 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 9.185185e-02 1.037 0 0
MET activates PTPN11 R-HSA-8865999 9.185185e-02 1.037 0 0
Type I hemidesmosome assembly R-HSA-446107 1.019689e-01 0.992 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.019689e-01 0.992 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.905609e-02 1.004 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.092526e-01 0.962 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.084434e-01 0.965 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.994451e-02 1.046 0 0
TGFBR3 expression R-HSA-9839394 9.783687e-02 1.009 0 0
Frs2-mediated activation R-HSA-170968 9.590182e-02 1.018 0 0
Myogenesis R-HSA-525793 1.092526e-01 0.962 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.018701e-01 0.992 0 0
Neurexins and neuroligins R-HSA-6794361 8.814935e-02 1.055 0 0
Signaling by TGFB family members R-HSA-9006936 9.970355e-02 1.001 1 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.990198e-02 1.046 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.045540e-01 0.981 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 9.185185e-02 1.037 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.365731e-02 1.028 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.994451e-02 1.046 0 0
FOXO-mediated transcription R-HSA-9614085 9.845608e-02 1.007 0 0
Potential therapeutics for SARS R-HSA-9679191 9.347797e-02 1.029 0 0
SARS-CoV Infections R-HSA-9679506 1.098783e-01 0.959 0 0
Recycling pathway of L1 R-HSA-437239 1.104805e-01 0.957 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.109607e-01 0.955 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.118007e-01 0.952 0 0
Signal transduction by L1 R-HSA-445144 1.123680e-01 0.949 0 0
Nephrin family interactions R-HSA-373753 1.123680e-01 0.949 0 0
Signaling by NOTCH R-HSA-157118 1.132524e-01 0.946 1 0
Striated Muscle Contraction R-HSA-390522 1.150462e-01 0.939 0 0
Vesicle-mediated transport R-HSA-5653656 1.165625e-01 0.933 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.183341e-01 0.927 0 0
Gluconeogenesis R-HSA-70263 1.194832e-01 0.923 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.196584e-01 0.922 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.196584e-01 0.922 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.213177e-01 0.916 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.213177e-01 0.916 0 0
ARMS-mediated activation R-HSA-170984 1.233216e-01 0.909 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.233216e-01 0.909 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 1.240535e-01 0.906 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.240535e-01 0.906 0 0
RAF activation R-HSA-5673000 1.260663e-01 0.899 0 0
Mitophagy R-HSA-5205647 1.260663e-01 0.899 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 1.264899e-01 0.898 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.264899e-01 0.898 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.264899e-01 0.898 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.264899e-01 0.898 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.282774e-01 0.892 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.287798e-01 0.890 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.287798e-01 0.890 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.287798e-01 0.890 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.830774e-01 0.737 0 0
Defective GALM causes GALAC4 R-HSA-9931929 1.830774e-01 0.737 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.830774e-01 0.737 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.830774e-01 0.737 0 0
Hereditary fructose intolerance R-HSA-5657560 1.830774e-01 0.737 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.830774e-01 0.737 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.616415e-01 0.582 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.616415e-01 0.582 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.616415e-01 0.582 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.616415e-01 0.582 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 2.616415e-01 0.582 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.616415e-01 0.582 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.616415e-01 0.582 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.616415e-01 0.582 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 2.616415e-01 0.582 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.616415e-01 0.582 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.584618e-01 0.800 0 0
G2 Phase R-HSA-68911 1.584618e-01 0.800 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.584618e-01 0.800 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 1.943551e-01 0.711 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.943551e-01 0.711 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.943551e-01 0.711 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.326542e-01 0.478 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.326542e-01 0.478 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.326542e-01 0.478 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.326542e-01 0.478 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.326542e-01 0.478 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.326542e-01 0.478 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.326542e-01 0.478 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.326542e-01 0.478 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.326542e-01 0.478 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.326542e-01 0.478 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.326542e-01 0.478 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.326542e-01 0.478 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 3.326542e-01 0.478 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.326542e-01 0.478 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.326542e-01 0.478 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.326542e-01 0.478 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.461265e-01 0.835 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.461265e-01 0.835 0 0
2-LTR circle formation R-HSA-164843 1.461265e-01 0.835 0 0
Signaling by LTK in cancer R-HSA-9842640 2.311301e-01 0.636 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.311301e-01 0.636 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.311301e-01 0.636 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.467541e-01 0.833 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.952462e-01 0.709 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.952462e-01 0.709 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.682859e-01 0.571 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.682859e-01 0.571 0 0
Regulation of PTEN localization R-HSA-8948747 2.682859e-01 0.571 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.682859e-01 0.571 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 2.682859e-01 0.571 0 0
SOS-mediated signalling R-HSA-112412 2.682859e-01 0.571 0 0
Axonal growth stimulation R-HSA-209563 3.968410e-01 0.401 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.968410e-01 0.401 0 0
Invadopodia formation R-HSA-8941237 3.968410e-01 0.401 0 0
MET activates RAS signaling R-HSA-8851805 2.211469e-01 0.655 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.211469e-01 0.655 0 0
Disorders of Nervous System Development R-HSA-9697154 2.211469e-01 0.655 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.211469e-01 0.655 0 0
Pervasive developmental disorders R-HSA-9005895 2.211469e-01 0.655 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.211469e-01 0.655 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.211469e-01 0.655 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.211469e-01 0.655 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.211469e-01 0.655 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.211469e-01 0.655 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.413790e-01 0.850 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.054094e-01 0.515 0 0
Formation of annular gap junctions R-HSA-196025 3.054094e-01 0.515 0 0
MET receptor recycling R-HSA-8875656 3.054094e-01 0.515 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.054094e-01 0.515 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.476780e-01 0.606 0 0
GAB1 signalosome R-HSA-180292 2.057134e-01 0.687 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.057134e-01 0.687 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 1.732646e-01 0.761 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 1.732646e-01 0.761 0 0
Activation of the pre-replicative complex R-HSA-68962 1.611581e-01 0.793 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 2.267187e-01 0.645 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.267187e-01 0.645 0 0
Lipophagy R-HSA-9613354 3.421634e-01 0.466 0 0
WNT mediated activation of DVL R-HSA-201688 3.421634e-01 0.466 0 0
Gap junction degradation R-HSA-190873 3.421634e-01 0.466 0 0
ALK mutants bind TKIs R-HSA-9700645 3.421634e-01 0.466 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.548575e-01 0.342 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.548575e-01 0.342 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.548575e-01 0.342 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.548575e-01 0.342 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.548575e-01 0.342 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.548575e-01 0.342 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.548575e-01 0.342 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.548575e-01 0.342 0 0
Trafficking of AMPA receptors R-HSA-399719 1.755532e-01 0.756 0 0
Negative regulation of MET activity R-HSA-6807004 2.482348e-01 0.605 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.019080e-01 0.520 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.019080e-01 0.520 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.019080e-01 0.520 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.701639e-01 0.568 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.782758e-01 0.422 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.782758e-01 0.422 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.782758e-01 0.422 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.782758e-01 0.422 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.884503e-01 0.725 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.439202e-01 0.613 0 0
Nucleosome assembly R-HSA-774815 1.730428e-01 0.762 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.730428e-01 0.762 0 0
HIV Transcription Elongation R-HSA-167169 2.022269e-01 0.694 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.022269e-01 0.694 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.022269e-01 0.694 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.924110e-01 0.534 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.924110e-01 0.534 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.924110e-01 0.534 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.626740e-01 0.581 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.626740e-01 0.581 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.977293e-01 0.704 0 0
Transcription of the HIV genome R-HSA-167172 1.534917e-01 0.814 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.416527e-01 0.849 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.308702e-01 0.637 0 0
HIV Transcription Initiation R-HSA-167161 2.308702e-01 0.637 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.308702e-01 0.637 0 0
Signaling by Erythropoietin R-HSA-9006335 2.817428e-01 0.550 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.817428e-01 0.550 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.566193e-01 0.448 0 0
Signaling by APC mutants R-HSA-4839744 4.135302e-01 0.383 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.135302e-01 0.383 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.135302e-01 0.383 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.135302e-01 0.383 0 0
IRS activation R-HSA-74713 5.072967e-01 0.295 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.072967e-01 0.295 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.045560e-01 0.689 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.374957e-01 0.472 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.607716e-01 0.584 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.838040e-01 0.416 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.916873e-01 0.535 0 0
Meiotic synapsis R-HSA-1221632 2.790978e-01 0.554 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.790978e-01 0.554 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.074478e-01 0.512 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.074478e-01 0.512 0 0
Translation initiation complex formation R-HSA-72649 2.934865e-01 0.532 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.828059e-01 0.417 0 0
G protein gated Potassium channels R-HSA-1296059 3.828059e-01 0.417 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.828059e-01 0.417 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.599892e-01 0.444 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.053533e-01 0.392 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.372508e-01 0.359 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.372508e-01 0.359 0 0
GRB2 events in EGFR signaling R-HSA-179812 4.808299e-01 0.318 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.808299e-01 0.318 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.995157e-01 0.398 0 0
Dual Incision in GG-NER R-HSA-5696400 3.995157e-01 0.398 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.995157e-01 0.398 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.277371e-01 0.369 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.633207e-01 0.334 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.633207e-01 0.334 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.633207e-01 0.334 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.633207e-01 0.334 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.633207e-01 0.334 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.498952e-01 0.347 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.126522e-01 0.290 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.321149e-01 0.479 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.043087e-01 0.393 0 0
G1/S-Specific Transcription R-HSA-69205 4.387710e-01 0.358 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.205594e-01 0.376 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.717713e-01 0.326 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.717713e-01 0.326 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.529046e-01 0.344 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.642349e-01 0.333 0 0
DAP12 signaling R-HSA-2424491 4.933142e-01 0.307 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.137661e-01 0.289 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.689491e-01 0.329 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.275700e-01 0.369 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.815772e-01 0.317 0 0
Neutrophil degranulation R-HSA-6798695 3.150811e-01 0.502 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.144786e-01 0.289 0 0
Dual incision in TC-NER R-HSA-6782135 5.006653e-01 0.300 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.228953e-01 0.491 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.010667e-01 0.521 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.387710e-01 0.358 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.076000e-01 0.683 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.674549e-01 0.435 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.933142e-01 0.307 0 0
Signaling by MET R-HSA-6806834 3.989501e-01 0.399 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.477578e-01 0.349 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.914682e-01 0.407 0 0
mRNA Capping R-HSA-72086 2.817428e-01 0.550 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.476780e-01 0.606 0 0
Formation of apoptosome R-HSA-111458 3.782758e-01 0.422 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.601623e-01 0.444 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.633207e-01 0.334 0 0
G0 and Early G1 R-HSA-1538133 1.904488e-01 0.720 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.566193e-01 0.448 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.391727e-01 0.470 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.934240e-01 0.533 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 3.995157e-01 0.398 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.812385e-01 0.419 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.952462e-01 0.709 0 0
Aggrephagy R-HSA-9646399 2.022269e-01 0.694 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.566193e-01 0.448 0 0
Developmental Cell Lineages R-HSA-9734767 2.272806e-01 0.643 0 0
Integration of provirus R-HSA-162592 1.952462e-01 0.709 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.482348e-01 0.605 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.689720e-01 0.570 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.633207e-01 0.334 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.391727e-01 0.470 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.933142e-01 0.307 0 0
Adipogenesis R-HSA-9843745 1.699013e-01 0.770 1 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 2.255420e-01 0.647 0 0
G-protein activation R-HSA-202040 2.701639e-01 0.568 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.881466e-01 0.540 1 1
COPI-mediated anterograde transport R-HSA-6807878 3.988981e-01 0.399 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.933142e-01 0.307 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.656322e-01 0.781 0 0
UCH proteinases R-HSA-5689603 2.353566e-01 0.628 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.184972e-01 0.285 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.340088e-01 0.873 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.045560e-01 0.689 1 0
Regulation of CDH11 function R-HSA-9762292 3.782758e-01 0.422 0 0
PI3K/AKT activation R-HSA-198203 3.782758e-01 0.422 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.022269e-01 0.694 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.477578e-01 0.349 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.402463e-01 0.468 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.127739e-01 0.384 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.560700e-01 0.341 0 0
TNF signaling R-HSA-75893 2.045560e-01 0.689 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.215906e-01 0.654 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.129845e-01 0.672 0 0
Signaling by ERBB2 R-HSA-1227986 3.825900e-01 0.417 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.584618e-01 0.800 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.057134e-01 0.687 0 0
Regulation of gap junction activity R-HSA-191650 4.548575e-01 0.342 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.058076e-01 0.687 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.601623e-01 0.444 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.601623e-01 0.444 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.808299e-01 0.318 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.808299e-01 0.318 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.277371e-01 0.369 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.963891e-01 0.304 0 0
Signaling by VEGF R-HSA-194138 1.830317e-01 0.737 0 0
Signaling by FGFR2 R-HSA-5654738 3.989501e-01 0.399 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.148841e-01 0.502 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.581839e-01 0.446 0 0
Signaling by FGFR4 R-HSA-5654743 2.607716e-01 0.584 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.148841e-01 0.502 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.372508e-01 0.359 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.968131e-01 0.304 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.769184e-01 0.752 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.019080e-01 0.520 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.019080e-01 0.520 0 0
Signal attenuation R-HSA-74749 3.782758e-01 0.422 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.439202e-01 0.613 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.377573e-01 0.624 0 0
Long-term potentiation R-HSA-9620244 3.828059e-01 0.417 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.808299e-01 0.318 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.327178e-01 0.633 0 0
GPER1 signaling R-HSA-9634597 4.987442e-01 0.302 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.162943e-01 0.287 0 0
Signaling by FGFR3 R-HSA-5654741 2.916873e-01 0.535 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.717713e-01 0.326 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.933142e-01 0.307 0 0
Signalling to ERKs R-HSA-187687 1.375985e-01 0.861 0 0
Signal amplification R-HSA-392518 2.377573e-01 0.624 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.404388e-01 0.619 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.584618e-01 0.800 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.943551e-01 0.711 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.461265e-01 0.835 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.421634e-01 0.466 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.058076e-01 0.687 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.566193e-01 0.448 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.072967e-01 0.295 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.289855e-01 0.640 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.309921e-01 0.275 0 0
Chromosome Maintenance R-HSA-73886 2.957972e-01 0.529 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.507625e-01 0.346 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.233685e-01 0.490 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.307517e-01 0.366 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.817428e-01 0.550 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.058076e-01 0.687 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.022980e-01 0.299 0 0
Oncogene Induced Senescence R-HSA-2559585 1.375985e-01 0.861 0 0
Signaling by WNT R-HSA-195721 3.945988e-01 0.404 0 0
Synthesis of DNA R-HSA-69239 4.275700e-01 0.369 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.395529e-01 0.357 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.421634e-01 0.466 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.010667e-01 0.521 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.978391e-01 0.526 0 0
Signaling by FGFR1 R-HSA-5654736 4.689491e-01 0.329 0 0
G alpha (z) signalling events R-HSA-418597 3.080476e-01 0.511 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.943551e-01 0.711 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 2.267187e-01 0.645 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.548575e-01 0.342 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.548575e-01 0.342 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.072967e-01 0.295 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.072967e-01 0.295 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.068302e-01 0.513 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.774034e-01 0.321 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.307439e-01 0.275 0 0
Generic Transcription Pathway R-HSA-212436 1.490852e-01 0.827 1 1
Signaling by NODAL R-HSA-1181150 4.633207e-01 0.334 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.901545e-01 0.721 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.927636e-01 0.715 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.192003e-01 0.378 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.842274e-01 0.546 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.584049e-01 0.588 0 0
Cilium Assembly R-HSA-5617833 2.928962e-01 0.533 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.119961e-01 0.674 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.211469e-01 0.655 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.769569e-01 0.752 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.584049e-01 0.588 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.149319e-01 0.382 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.225446e-01 0.282 0 0
p75NTR signals via NF-kB R-HSA-193639 3.019080e-01 0.520 0 0
Interleukin-35 Signalling R-HSA-8984722 4.808299e-01 0.318 0 0
Protein folding R-HSA-391251 3.389628e-01 0.470 0 0
Protein ubiquitination R-HSA-8852135 4.620335e-01 0.335 0 0
Ion homeostasis R-HSA-5578775 4.689491e-01 0.329 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.953455e-01 0.305 0 0
Opioid Signalling R-HSA-111885 4.953455e-01 0.305 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.686781e-01 0.329 0 0
Cardiogenesis R-HSA-9733709 2.058076e-01 0.687 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.830774e-01 0.737 0 0
Inhibition of PKR R-HSA-169131 1.830774e-01 0.737 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.616415e-01 0.582 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.326542e-01 0.478 0 0
Interleukin-33 signaling R-HSA-9014843 3.326542e-01 0.478 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.326542e-01 0.478 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.326542e-01 0.478 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.326542e-01 0.478 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 3.326542e-01 0.478 0 0
C6 deamination of adenosine R-HSA-75102 3.326542e-01 0.478 0 0
Signalling to ERK5 R-HSA-198765 3.326542e-01 0.478 0 0
Bicarbonate transporters R-HSA-425381 1.701714e-01 0.769 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.682859e-01 0.571 0 0
MET activates STAT3 R-HSA-8875791 3.968410e-01 0.401 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.054094e-01 0.515 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.054094e-01 0.515 0 0
Co-stimulation by ICOS R-HSA-9927354 3.054094e-01 0.515 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.732646e-01 0.761 0 0
Unwinding of DNA R-HSA-176974 3.421634e-01 0.466 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.421634e-01 0.466 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.548575e-01 0.342 0 0
GABA synthesis R-HSA-888568 4.548575e-01 0.342 0 0
DCC mediated attractive signaling R-HSA-418885 3.019080e-01 0.520 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.019080e-01 0.520 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.782758e-01 0.422 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.292773e-01 0.482 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 3.292773e-01 0.482 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.135302e-01 0.383 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.477578e-01 0.349 0 0
Signaling by AXIN mutants R-HSA-4839735 4.477578e-01 0.349 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.663523e-01 0.779 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.940591e-01 0.532 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.372508e-01 0.359 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.808299e-01 0.318 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.126522e-01 0.290 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.126522e-01 0.290 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.043087e-01 0.393 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.467452e-01 0.350 0 0
Budding and maturation of HIV virion R-HSA-162588 5.144786e-01 0.289 0 0
Degradation of CDH1 R-HSA-9766229 5.157101e-01 0.288 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.670612e-01 0.573 0 0
Ub-specific processing proteases R-HSA-5689880 1.736237e-01 0.760 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.698457e-01 0.569 0 0
HDMs demethylate histones R-HSA-3214842 3.828059e-01 0.417 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.233685e-01 0.490 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.105836e-01 0.677 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.916873e-01 0.535 0 0
HATs acetylate histones R-HSA-3214847 2.294151e-01 0.639 0 0
Signaling by NOTCH3 R-HSA-9012852 1.927636e-01 0.715 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.292773e-01 0.482 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.760884e-01 0.322 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.058076e-01 0.687 0 0
Interferon alpha/beta signaling R-HSA-909733 3.287458e-01 0.483 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.366921e-01 0.360 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.760884e-01 0.322 0 0
Post NMDA receptor activation events R-HSA-438064 5.050005e-01 0.297 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.091230e-01 0.293 0 0
Signaling by TGFBR3 R-HSA-9839373 1.852090e-01 0.732 0 0
Signaling by NTRKs R-HSA-166520 4.149319e-01 0.382 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.461265e-01 0.835 0 0
Rap1 signalling R-HSA-392517 2.267187e-01 0.645 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.421634e-01 0.466 0 0
Amino acid transport across the plasma membrane R-HSA-352230 5.162943e-01 0.287 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.655840e-01 0.332 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.091230e-01 0.293 0 0
Mitotic Prophase R-HSA-68875 1.412092e-01 0.850 0 0
Ion transport by P-type ATPases R-HSA-936837 4.428959e-01 0.354 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 1.584618e-01 0.800 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.569878e-01 0.804 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.058076e-01 0.687 0 0
Interleukin-27 signaling R-HSA-9020956 3.782758e-01 0.422 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.884503e-01 0.725 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.072967e-01 0.295 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.924541e-01 0.716 0 0
Muscle contraction R-HSA-397014 4.827792e-01 0.316 0 0
Base Excision Repair R-HSA-73884 4.180665e-01 0.379 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 2.682859e-01 0.571 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.057134e-01 0.687 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.072967e-01 0.295 0 0
Downstream signal transduction R-HSA-186763 3.205870e-01 0.494 0 0
Smooth Muscle Contraction R-HSA-445355 2.790978e-01 0.554 0 0
Platelet calcium homeostasis R-HSA-418360 4.717713e-01 0.326 0 0
Interleukin-1 signaling R-HSA-9020702 3.468582e-01 0.460 0 0
FLT3 Signaling R-HSA-9607240 5.335319e-01 0.273 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.601623e-01 0.444 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.689720e-01 0.570 0 0
Signaling by SCF-KIT R-HSA-1433557 1.498472e-01 0.824 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.581852e-01 0.339 0 0
Generation of second messenger molecules R-HSA-202433 5.151088e-01 0.288 0 0
Interleukin-6 signaling R-HSA-1059683 2.476780e-01 0.606 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.346937e-01 0.871 0 0
MHC class II antigen presentation R-HSA-2132295 5.200246e-01 0.284 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.616415e-01 0.582 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.311301e-01 0.636 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.476780e-01 0.606 0 0
Protein methylation R-HSA-8876725 3.019080e-01 0.520 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.058076e-01 0.687 0 0
Interleukin-36 pathway R-HSA-9014826 5.072967e-01 0.295 0 0
Inositol transporters R-HSA-429593 5.072967e-01 0.295 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.072967e-01 0.295 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.477578e-01 0.349 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.797626e-01 0.420 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.808299e-01 0.318 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.277371e-01 0.369 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.367666e-01 0.360 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.321149e-01 0.479 0 0
Signaling by KIT in disease R-HSA-9669938 3.148841e-01 0.502 0 0
Sensory processing of sound R-HSA-9659379 1.770726e-01 0.752 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.442767e-01 0.352 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.730428e-01 0.762 0 0
Basigin interactions R-HSA-210991 2.701639e-01 0.568 0 0
Protein hydroxylation R-HSA-9629569 4.633207e-01 0.334 0 0
Other interleukin signaling R-HSA-449836 4.372508e-01 0.359 0 0
Signaling by Interleukins R-HSA-449147 2.149179e-01 0.668 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.413790e-01 0.850 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.421634e-01 0.466 0 0
Suppression of apoptosis R-HSA-9635465 4.135302e-01 0.383 0 0
Signaling by FGFR2 in disease R-HSA-5655253 3.717844e-01 0.430 0 0
Kinesins R-HSA-983189 3.825900e-01 0.417 0 0
Interleukin-7 signaling R-HSA-1266695 2.076000e-01 0.683 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.759313e-01 0.425 0 0
DNA Damage Bypass R-HSA-73893 5.157101e-01 0.288 0 0
Signaling by ALK R-HSA-201556 4.963891e-01 0.304 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.131071e-01 0.504 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.131071e-01 0.504 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.131071e-01 0.504 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.429707e-01 0.465 0 0
NrCAM interactions R-HSA-447038 1.584618e-01 0.800 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.326542e-01 0.478 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.682859e-01 0.571 0 0
Regulation of KIT signaling R-HSA-1433559 2.746556e-01 0.561 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.612497e-01 0.793 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.782758e-01 0.422 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.439202e-01 0.613 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.072967e-01 0.295 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.072967e-01 0.295 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.045560e-01 0.689 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.477578e-01 0.349 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.126522e-01 0.290 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.277371e-01 0.369 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.888477e-01 0.311 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.992250e-01 0.701 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.183973e-01 0.497 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.601623e-01 0.444 0 0
Neurodegenerative Diseases R-HSA-8863678 3.601623e-01 0.444 0 0
Regulated Necrosis R-HSA-5218859 5.022980e-01 0.299 0 0
Gene Silencing by RNA R-HSA-211000 2.301042e-01 0.638 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.870036e-01 0.412 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.566193e-01 0.448 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.335319e-01 0.273 0 0
Specification of primordial germ cells R-HSA-9827857 1.853181e-01 0.732 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.372508e-01 0.359 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.746556e-01 0.561 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.421634e-01 0.466 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.019080e-01 0.520 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.477578e-01 0.349 0 0
Signaling by LTK R-HSA-9842663 4.808299e-01 0.318 0 0
Heme signaling R-HSA-9707616 4.127739e-01 0.384 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.774034e-01 0.321 0 0
Inositol phosphate metabolism R-HSA-1483249 2.779500e-01 0.556 0 0
Interleukin-15 signaling R-HSA-8983432 4.808299e-01 0.318 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.774034e-01 0.321 0 0
Pyroptosis R-HSA-5620971 2.626740e-01 0.581 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.126522e-01 0.290 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.135302e-01 0.383 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.242985e-01 0.649 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.838040e-01 0.416 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.072967e-01 0.295 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.477578e-01 0.349 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.649059e-01 0.577 0 0
OAS antiviral response R-HSA-8983711 4.808299e-01 0.318 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.421634e-01 0.466 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.106511e-01 0.508 0 0
Glucagon-type ligand receptors R-HSA-420092 4.717713e-01 0.326 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.927709e-01 0.715 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.126522e-01 0.290 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.232397e-01 0.490 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.072967e-01 0.295 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 2.057134e-01 0.687 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 3.148841e-01 0.502 0 0
Cellular response to chemical stress R-HSA-9711123 5.340330e-01 0.272 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.352242e-01 0.271 0 0
DNA strand elongation R-HSA-69190 5.352242e-01 0.271 0 0
Signaling by WNT in cancer R-HSA-4791275 5.352242e-01 0.271 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.352242e-01 0.271 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.380211e-01 0.269 0 0
FGFR2 alternative splicing R-HSA-6803529 5.380211e-01 0.269 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.380211e-01 0.269 0 0
Notch-HLH transcription pathway R-HSA-350054 5.380211e-01 0.269 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.380211e-01 0.269 0 0
Developmental Biology R-HSA-1266738 5.403372e-01 0.267 1 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.431592e-01 0.265 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.431592e-01 0.265 0 0
Signal regulatory protein family interactions R-HSA-391160 5.431592e-01 0.265 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.431592e-01 0.265 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.431592e-01 0.265 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.455394e-01 0.263 0 0
Aquaporin-mediated transport R-HSA-445717 5.469966e-01 0.262 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.516310e-01 0.258 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.538808e-01 0.257 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.546943e-01 0.256 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.546943e-01 0.256 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.546943e-01 0.256 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.546943e-01 0.256 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.546943e-01 0.256 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.546943e-01 0.256 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.546943e-01 0.256 0 0
Proton/oligopeptide cotransporters R-HSA-427975 5.546943e-01 0.256 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.546943e-01 0.256 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.546943e-01 0.256 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.546943e-01 0.256 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.546943e-01 0.256 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.546943e-01 0.256 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.546943e-01 0.256 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.555157e-01 0.255 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.555157e-01 0.255 0 0
Nuclear RNA decay R-HSA-9930044 5.555157e-01 0.255 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.555157e-01 0.255 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.555157e-01 0.255 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.583066e-01 0.253 0 0
DNA Replication R-HSA-69306 5.603835e-01 0.252 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.615678e-01 0.251 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.615678e-01 0.251 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.615678e-01 0.251 0 0
Mitochondrial protein import R-HSA-1268020 5.620351e-01 0.250 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.620351e-01 0.250 0 0
Rab regulation of trafficking R-HSA-9007101 5.639985e-01 0.249 0 0
Activation of GABAB receptors R-HSA-991365 5.693813e-01 0.245 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.693813e-01 0.245 0 0
GABA B receptor activation R-HSA-977444 5.693813e-01 0.245 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.693813e-01 0.245 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.693813e-01 0.245 0 0
Erythropoietin activates RAS R-HSA-9027284 5.723095e-01 0.242 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.723095e-01 0.242 0 0
SHC1 events in EGFR signaling R-HSA-180336 5.723095e-01 0.242 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.723095e-01 0.242 0 0
Signaling by Activin R-HSA-1502540 5.723095e-01 0.242 0 0
Ca2+ pathway R-HSA-4086398 5.735078e-01 0.241 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.753229e-01 0.240 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.753229e-01 0.240 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.768439e-01 0.239 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.811110e-01 0.236 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.843704e-01 0.233 0 0
Deadenylation of mRNA R-HSA-429947 5.843704e-01 0.233 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.843704e-01 0.233 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.843704e-01 0.233 0 0
Interleukin-6 family signaling R-HSA-6783589 5.843704e-01 0.233 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.902410e-01 0.229 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.903830e-01 0.229 0 0
Viral Infection Pathways R-HSA-9824446 5.924157e-01 0.227 1 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.946199e-01 0.226 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.946199e-01 0.226 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.946199e-01 0.226 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.946199e-01 0.226 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.946199e-01 0.226 0 0
MAPK family signaling cascades R-HSA-5683057 5.954077e-01 0.225 0 0
Meiosis R-HSA-1500620 5.965505e-01 0.224 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.967493e-01 0.224 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.975349e-01 0.224 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.975349e-01 0.224 0 0
STAT5 Activation R-HSA-9645135 5.975349e-01 0.224 0 0
MET Receptor Activation R-HSA-6806942 5.975349e-01 0.224 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.975349e-01 0.224 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.975349e-01 0.224 0 0
HDL clearance R-HSA-8964011 5.975349e-01 0.224 0 0
Nef and signal transduction R-HSA-164944 5.975349e-01 0.224 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.999629e-01 0.222 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.000817e-01 0.222 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.000817e-01 0.222 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.000817e-01 0.222 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.000817e-01 0.222 0 0
Activation of SMO R-HSA-5635838 6.000817e-01 0.222 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.000817e-01 0.222 0 0
Killing mechanisms R-HSA-9664420 6.000817e-01 0.222 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.000817e-01 0.222 0 0
Negative regulation of FLT3 R-HSA-9706369 6.000817e-01 0.222 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.064016e-01 0.217 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.064016e-01 0.217 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.064016e-01 0.217 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.064016e-01 0.217 0 0
Cellular response to starvation R-HSA-9711097 6.073785e-01 0.217 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.107703e-01 0.214 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.133856e-01 0.212 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.133856e-01 0.212 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.133856e-01 0.212 0 0
Signaling by NOTCH1 R-HSA-1980143 6.139156e-01 0.212 1 0
Interferon gamma signaling R-HSA-877300 6.165118e-01 0.210 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.203356e-01 0.207 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.204966e-01 0.207 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.264713e-01 0.203 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.264713e-01 0.203 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.264713e-01 0.203 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.264713e-01 0.203 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.276416e-01 0.202 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.276416e-01 0.202 0 0
Metalloprotease DUBs R-HSA-5689901 6.276416e-01 0.202 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.285954e-01 0.202 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.285954e-01 0.202 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.316025e-01 0.200 0 0
RNA Polymerase III Transcription R-HSA-74158 6.316025e-01 0.200 0 0
RUNX2 regulates bone development R-HSA-8941326 6.316025e-01 0.200 0 0
GPVI-mediated activation cascade R-HSA-114604 6.316025e-01 0.200 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.319498e-01 0.199 0 0
tRNA processing R-HSA-72306 6.319498e-01 0.199 0 0
SLC-mediated transport of amino acids R-HSA-9958863 6.335191e-01 0.198 0 0
Toll-like Receptor Cascades R-HSA-168898 6.357676e-01 0.197 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.362563e-01 0.196 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.362563e-01 0.196 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.362563e-01 0.196 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.362563e-01 0.196 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.362563e-01 0.196 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.362563e-01 0.196 0 0
Recycling of eIF2:GDP R-HSA-72731 6.362563e-01 0.196 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.362563e-01 0.196 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.362563e-01 0.196 0 0
Disinhibition of SNARE formation R-HSA-114516 6.362563e-01 0.196 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.362563e-01 0.196 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 6.362563e-01 0.196 0 0
VLDL clearance R-HSA-8964046 6.362563e-01 0.196 0 0
CHL1 interactions R-HSA-447041 6.362563e-01 0.196 0 0
IRS-mediated signalling R-HSA-112399 6.417136e-01 0.193 0 0
Peptide chain elongation R-HSA-156902 6.456287e-01 0.190 0 0
Diseases of programmed cell death R-HSA-9645723 6.456287e-01 0.190 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.463189e-01 0.190 0 0
Interleukin-1 family signaling R-HSA-446652 6.463189e-01 0.190 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.480774e-01 0.188 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.480774e-01 0.188 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 6.480774e-01 0.188 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.490944e-01 0.188 0 0
Signaling by ROBO receptors R-HSA-376176 6.495567e-01 0.187 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.514871e-01 0.186 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.514871e-01 0.186 0 0
Glycogen storage diseases R-HSA-3229121 6.514871e-01 0.186 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.514871e-01 0.186 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.514871e-01 0.186 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 6.560142e-01 0.183 0 0
Signaling by FGFR R-HSA-190236 6.623775e-01 0.179 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.640716e-01 0.178 1 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.644929e-01 0.178 0 0
MET promotes cell motility R-HSA-8875878 6.663402e-01 0.176 0 0
NGF-stimulated transcription R-HSA-9031628 6.675256e-01 0.176 0 0
Co-stimulation by CD28 R-HSA-389356 6.675256e-01 0.176 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.677021e-01 0.175 0 0
phospho-PLA2 pathway R-HSA-111995 6.712543e-01 0.173 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.712543e-01 0.173 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.712543e-01 0.173 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.712543e-01 0.173 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.712543e-01 0.173 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.712543e-01 0.173 0 0
Regulation by c-FLIP R-HSA-3371378 6.712543e-01 0.173 0 0
Interleukin-9 signaling R-HSA-8985947 6.712543e-01 0.173 0 0
Adrenoceptors R-HSA-390696 6.712543e-01 0.173 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.712543e-01 0.173 0 0
Dimerization of procaspase-8 R-HSA-69416 6.712543e-01 0.173 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.712543e-01 0.173 0 0
Sodium/Proton exchangers R-HSA-425986 6.712543e-01 0.173 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.712543e-01 0.173 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.751492e-01 0.171 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 6.751492e-01 0.171 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.751492e-01 0.171 0 0
Apoptotic factor-mediated response R-HSA-111471 6.751492e-01 0.171 0 0
Tie2 Signaling R-HSA-210993 6.751492e-01 0.171 0 0
Mismatch Repair R-HSA-5358508 6.751492e-01 0.171 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.751492e-01 0.171 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.811382e-01 0.167 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.823706e-01 0.166 1 1
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.856139e-01 0.164 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.856139e-01 0.164 0 0
DARPP-32 events R-HSA-180024 6.865142e-01 0.163 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.865142e-01 0.163 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.865142e-01 0.163 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.882346e-01 0.162 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.967414e-01 0.157 0 0
MAP kinase activation R-HSA-450294 6.967414e-01 0.157 0 0
PI3K Cascade R-HSA-109704 6.967630e-01 0.157 0 0
Regulation of signaling by CBL R-HSA-912631 6.974865e-01 0.156 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.974865e-01 0.156 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.974865e-01 0.156 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.974865e-01 0.156 0 0
The NLRP3 inflammasome R-HSA-844456 6.974865e-01 0.156 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 6.974865e-01 0.156 0 0
Translesion Synthesis by POLH R-HSA-110320 6.974865e-01 0.156 0 0
Maturation of nucleoprotein R-HSA-9694631 6.974865e-01 0.156 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.987664e-01 0.156 0 0
Interleukin-2 family signaling R-HSA-451927 6.987664e-01 0.156 0 0
Ribosome-associated quality control R-HSA-9948299 6.989563e-01 0.156 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.997006e-01 0.155 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.028869e-01 0.153 0 0
CASP8 activity is inhibited R-HSA-5218900 7.028869e-01 0.153 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.028869e-01 0.153 0 0
Calcineurin activates NFAT R-HSA-2025928 7.028869e-01 0.153 0 0
Interleukin-21 signaling R-HSA-9020958 7.028869e-01 0.153 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.028869e-01 0.153 0 0
mRNA Editing R-HSA-75072 7.028869e-01 0.153 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.028869e-01 0.153 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.028869e-01 0.153 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.028869e-01 0.153 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.028869e-01 0.153 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.028869e-01 0.153 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.028869e-01 0.153 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.028869e-01 0.153 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.045170e-01 0.152 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.045170e-01 0.152 0 0
Interleukin-37 signaling R-HSA-9008059 7.045170e-01 0.152 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.095754e-01 0.149 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.095754e-01 0.149 0 0
Signaling by PDGF R-HSA-186797 7.095754e-01 0.149 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.102002e-01 0.149 0 0
Reproduction R-HSA-1474165 7.131616e-01 0.147 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.181366e-01 0.144 0 0
Glycogen synthesis R-HSA-3322077 7.185348e-01 0.144 0 0
Signaling by NOTCH4 R-HSA-9013694 7.214256e-01 0.142 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.235424e-01 0.141 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.314774e-01 0.136 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.314774e-01 0.136 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.314774e-01 0.136 0 0
Binding and entry of HIV virion R-HSA-173107 7.314774e-01 0.136 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.314774e-01 0.136 0 0
DNA replication initiation R-HSA-68952 7.314774e-01 0.136 0 0
Pexophagy R-HSA-9664873 7.314774e-01 0.136 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.314774e-01 0.136 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.314774e-01 0.136 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.314774e-01 0.136 0 0
Maturation of spike protein R-HSA-9683686 7.314774e-01 0.136 0 0
Signaling by Leptin R-HSA-2586552 7.314774e-01 0.136 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.314774e-01 0.136 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.329116e-01 0.135 0 0
Insulin receptor signalling cascade R-HSA-74751 7.341143e-01 0.134 0 0
IGF1R signaling cascade R-HSA-2428924 7.341143e-01 0.134 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.383352e-01 0.132 0 0
Lagging Strand Synthesis R-HSA-69186 7.383352e-01 0.132 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.383352e-01 0.132 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.383352e-01 0.132 0 0
Protein localization R-HSA-9609507 7.429340e-01 0.129 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.429591e-01 0.129 0 0
Ca-dependent events R-HSA-111996 7.430429e-01 0.129 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.458178e-01 0.127 0 0
HCMV Early Events R-HSA-9609690 7.520290e-01 0.124 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.522922e-01 0.124 1 1
Regulation of necroptotic cell death R-HSA-5675482 7.537603e-01 0.123 0 0
G1/S Transition R-HSA-69206 7.538504e-01 0.123 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.566510e-01 0.121 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.569331e-01 0.121 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.569331e-01 0.121 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.569331e-01 0.121 0 0
Serine metabolism R-HSA-977347 7.569331e-01 0.121 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.569331e-01 0.121 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.573182e-01 0.121 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.573182e-01 0.121 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.573182e-01 0.121 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.573182e-01 0.121 0 0
vRNA Synthesis R-HSA-192814 7.573182e-01 0.121 0 0
vRNP Assembly R-HSA-192905 7.573182e-01 0.121 0 0
Conjugation of benzoate with glycine R-HSA-177135 7.573182e-01 0.121 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.573182e-01 0.121 0 0
LGI-ADAM interactions R-HSA-5682910 7.573182e-01 0.121 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.573182e-01 0.121 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.573182e-01 0.121 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.646878e-01 0.117 0 0
G-protein mediated events R-HSA-112040 7.680977e-01 0.115 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.686326e-01 0.114 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.686326e-01 0.114 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.686326e-01 0.114 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.686326e-01 0.114 0 0
DAP12 interactions R-HSA-2172127 7.696951e-01 0.114 0 0
RMTs methylate histone arginines R-HSA-3214858 7.696951e-01 0.114 0 0
G1 Phase R-HSA-69236 7.696951e-01 0.114 0 0
Cyclin D associated events in G1 R-HSA-69231 7.696951e-01 0.114 0 0
Netrin-1 signaling R-HSA-373752 7.696951e-01 0.114 0 0
Stimuli-sensing channels R-HSA-2672351 7.699308e-01 0.114 0 0
Regulation of insulin secretion R-HSA-422356 7.706747e-01 0.113 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.735496e-01 0.112 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.743763e-01 0.111 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.743763e-01 0.111 0 0
LDL clearance R-HSA-8964038 7.743763e-01 0.111 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.743763e-01 0.111 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.743763e-01 0.111 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.747014e-01 0.111 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.806736e-01 0.108 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.806736e-01 0.108 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.806736e-01 0.108 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.806736e-01 0.108 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 7.806736e-01 0.108 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.806736e-01 0.108 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.806736e-01 0.108 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.806736e-01 0.108 0 0
NF-kB is activated and signals survival R-HSA-209560 7.806736e-01 0.108 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.806736e-01 0.108 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.806736e-01 0.108 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.806736e-01 0.108 0 0
Sodium/Calcium exchangers R-HSA-425561 7.806736e-01 0.108 0 0
Somitogenesis R-HSA-9824272 7.821842e-01 0.107 0 0
DAG and IP3 signaling R-HSA-1489509 7.821842e-01 0.107 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.827633e-01 0.106 0 0
rRNA processing R-HSA-72312 7.830649e-01 0.106 0 0
TCR signaling R-HSA-202403 7.865942e-01 0.104 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.903614e-01 0.102 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.907150e-01 0.102 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.907150e-01 0.102 0 0
Growth hormone receptor signaling R-HSA-982772 7.907150e-01 0.102 0 0
Diseases of DNA repair R-HSA-9675135 7.941288e-01 0.100 0 0
Regulation of Apoptosis R-HSA-169911 7.961729e-01 0.099 0 0
PERK regulates gene expression R-HSA-381042 7.961729e-01 0.099 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.963859e-01 0.099 0 0
Interleukin-17 signaling R-HSA-448424 7.987405e-01 0.098 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.990416e-01 0.097 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.017826e-01 0.096 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.017826e-01 0.096 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.017826e-01 0.096 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.017826e-01 0.096 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.017826e-01 0.096 0 0
Regulation of IFNG signaling R-HSA-877312 8.017826e-01 0.096 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.017826e-01 0.096 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.017826e-01 0.096 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.017826e-01 0.096 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.017826e-01 0.096 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.017826e-01 0.096 0 0
Polymerase switching R-HSA-69091 8.017826e-01 0.096 0 0
Leading Strand Synthesis R-HSA-69109 8.017826e-01 0.096 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.017826e-01 0.096 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.020713e-01 0.096 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.023668e-01 0.096 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.023668e-01 0.096 0 0
PI Metabolism R-HSA-1483255 8.044650e-01 0.094 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.060000e-01 0.094 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.060000e-01 0.094 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.088833e-01 0.092 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.088833e-01 0.092 0 0
Calmodulin induced events R-HSA-111933 8.088833e-01 0.092 0 0
CaM pathway R-HSA-111997 8.088833e-01 0.092 0 0
Glycosphingolipid transport R-HSA-9845576 8.088833e-01 0.092 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.088833e-01 0.092 0 0
Transmission across Chemical Synapses R-HSA-112315 8.115152e-01 0.091 0 0
GABA receptor activation R-HSA-977443 8.158569e-01 0.088 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.173678e-01 0.088 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.173678e-01 0.088 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.183090e-01 0.087 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.202827e-01 0.086 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.202827e-01 0.086 0 0
Tight junction interactions R-HSA-420029 8.202827e-01 0.086 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.202827e-01 0.086 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.208611e-01 0.086 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.208611e-01 0.086 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.208611e-01 0.086 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.208611e-01 0.086 0 0
Maturation of nucleoprotein R-HSA-9683610 8.208611e-01 0.086 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.208611e-01 0.086 0 0
Degradation of DVL R-HSA-4641258 8.209176e-01 0.086 0 0
HCMV Infection R-HSA-9609646 8.218515e-01 0.085 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.234578e-01 0.084 0 0
PLC beta mediated events R-HSA-112043 8.253818e-01 0.083 0 0
Gap junction trafficking and regulation R-HSA-157858 8.268177e-01 0.083 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.272588e-01 0.082 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.272588e-01 0.082 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.310663e-01 0.080 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.322996e-01 0.080 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.336145e-01 0.079 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.336145e-01 0.079 0 0
Sphingolipid catabolism R-HSA-9845614 8.336145e-01 0.079 0 0
TRP channels R-HSA-3295583 8.336145e-01 0.079 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.345036e-01 0.079 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.347076e-01 0.078 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.360866e-01 0.078 0 0
Removal of the Flap Intermediate R-HSA-69166 8.381043e-01 0.077 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.381043e-01 0.077 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.381043e-01 0.077 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.381043e-01 0.077 0 0
Hydrolysis of LPC R-HSA-1483115 8.381043e-01 0.077 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.381043e-01 0.077 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.381043e-01 0.077 0 0
Physiological factors R-HSA-5578768 8.381043e-01 0.077 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.381043e-01 0.077 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.381043e-01 0.077 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.381043e-01 0.077 0 0
Eukaryotic Translation Termination R-HSA-72764 8.384161e-01 0.077 0 0
Co-inhibition by PD-1 R-HSA-389948 8.399670e-01 0.076 0 0
Ion channel transport R-HSA-983712 8.402410e-01 0.076 0 0
Platelet homeostasis R-HSA-418346 8.412802e-01 0.075 0 0
Neuronal System R-HSA-112316 8.420410e-01 0.075 0 0
Stabilization of p53 R-HSA-69541 8.430537e-01 0.074 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.430537e-01 0.074 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.430537e-01 0.074 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.432320e-01 0.074 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.432320e-01 0.074 0 0
Integration of energy metabolism R-HSA-163685 8.456134e-01 0.073 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.460461e-01 0.073 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.460461e-01 0.073 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.497708e-01 0.071 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.515773e-01 0.070 0 0
Telomere Maintenance R-HSA-157579 8.523569e-01 0.069 0 0
Diseases of Immune System R-HSA-5260271 8.532047e-01 0.069 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.532047e-01 0.069 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.536887e-01 0.069 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.536887e-01 0.069 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.536887e-01 0.069 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.536887e-01 0.069 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.536887e-01 0.069 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.536887e-01 0.069 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.536887e-01 0.069 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 8.536887e-01 0.069 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.536887e-01 0.069 0 0
Other semaphorin interactions R-HSA-416700 8.536887e-01 0.069 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.550785e-01 0.068 0 0
Orc1 removal from chromatin R-HSA-68949 8.550785e-01 0.068 0 0
Telomere Extension By Telomerase R-HSA-171319 8.576271e-01 0.067 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.576271e-01 0.067 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.576271e-01 0.067 0 0
Inflammasomes R-HSA-622312 8.576271e-01 0.067 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.579851e-01 0.067 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.627776e-01 0.064 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.627776e-01 0.064 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.635842e-01 0.064 0 0
PCP/CE pathway R-HSA-4086400 8.651463e-01 0.063 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.651596e-01 0.063 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.677737e-01 0.062 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.677737e-01 0.062 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.677737e-01 0.062 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.677737e-01 0.062 0 0
Fructose catabolism R-HSA-70350 8.677737e-01 0.062 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.677737e-01 0.062 0 0
Differentiation of T cells R-HSA-9945266 8.677737e-01 0.062 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.677737e-01 0.062 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.677737e-01 0.062 0 0
Attachment and Entry R-HSA-9678110 8.677737e-01 0.062 0 0
Mitochondrial Uncoupling R-HSA-166187 8.677737e-01 0.062 0 0
Virus Assembly and Release R-HSA-168268 8.677737e-01 0.062 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.684062e-01 0.061 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.684062e-01 0.061 0 0
Neurotransmitter release cycle R-HSA-112310 8.711893e-01 0.060 0 0
Intra-Golgi traffic R-HSA-6811438 8.717970e-01 0.060 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.717970e-01 0.060 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.729200e-01 0.059 0 0
Selenocysteine synthesis R-HSA-2408557 8.773381e-01 0.057 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.784302e-01 0.056 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.802879e-01 0.055 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.805035e-01 0.055 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.805035e-01 0.055 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.805035e-01 0.055 0 0
Passive transport by Aquaporins R-HSA-432047 8.805035e-01 0.055 0 0
Galactose catabolism R-HSA-70370 8.805035e-01 0.055 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.843682e-01 0.053 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.848499e-01 0.053 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.877447e-01 0.052 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.877447e-01 0.052 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.877447e-01 0.052 0 0
Defective pyroptosis R-HSA-9710421 8.882745e-01 0.051 0 0
Viral mRNA Translation R-HSA-192823 8.884612e-01 0.051 0 0
Signaling by Insulin receptor R-HSA-74752 8.891021e-01 0.051 0 0
SLC transporter disorders R-HSA-5619102 8.912039e-01 0.050 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.920085e-01 0.050 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.920085e-01 0.050 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.920085e-01 0.050 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.920085e-01 0.050 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.920085e-01 0.050 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.920085e-01 0.050 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.920085e-01 0.050 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.920085e-01 0.050 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.942070e-01 0.049 0 0
Gap junction trafficking R-HSA-190828 8.957809e-01 0.048 0 0
HCMV Late Events R-HSA-9610379 8.976834e-01 0.047 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.999569e-01 0.046 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.001755e-01 0.046 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.020614e-01 0.045 0 0
PKA activation R-HSA-163615 9.024064e-01 0.045 0 0
PKA activation in glucagon signalling R-HSA-164378 9.024064e-01 0.045 0 0
Polo-like kinase mediated events R-HSA-156711 9.024064e-01 0.045 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.024064e-01 0.045 0 0
Platelet sensitization by LDL R-HSA-432142 9.024064e-01 0.045 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.024064e-01 0.045 0 0
Nephron development R-HSA-9831926 9.024064e-01 0.045 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.028306e-01 0.044 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.028306e-01 0.044 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.028306e-01 0.044 0 0
Integrin signaling R-HSA-354192 9.044179e-01 0.044 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.045099e-01 0.044 0 0
Extension of Telomeres R-HSA-180786 9.061100e-01 0.043 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.061100e-01 0.043 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.105639e-01 0.041 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.118037e-01 0.040 0 0
Specification of the neural plate border R-HSA-9834899 9.118037e-01 0.040 0 0
Amino Acid conjugation R-HSA-156587 9.118037e-01 0.040 0 0
Conjugation of carboxylic acids R-HSA-159424 9.118037e-01 0.040 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.118037e-01 0.040 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.118037e-01 0.040 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.118037e-01 0.040 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.118584e-01 0.040 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.118584e-01 0.040 0 0
Heme degradation R-HSA-189483 9.118584e-01 0.040 0 0
RAB geranylgeranylation R-HSA-8873719 9.119250e-01 0.040 0 0
tRNA Aminoacylation R-HSA-379724 9.119250e-01 0.040 0 0
Gastrulation R-HSA-9758941 9.122381e-01 0.040 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.174170e-01 0.037 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.187528e-01 0.037 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.187528e-01 0.037 0 0
Hyaluronan metabolism R-HSA-2142845 9.187528e-01 0.037 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.187528e-01 0.037 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.187528e-01 0.037 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.202966e-01 0.036 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.202966e-01 0.036 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.202966e-01 0.036 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.202966e-01 0.036 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.202966e-01 0.036 0 0
Pregnenolone biosynthesis R-HSA-196108 9.202966e-01 0.036 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.228885e-01 0.035 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.251374e-01 0.034 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.269115e-01 0.033 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.269115e-01 0.033 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.269115e-01 0.033 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.274899e-01 0.033 0 0
Signaling by PTK6 R-HSA-8848021 9.274899e-01 0.033 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.279722e-01 0.032 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.279722e-01 0.032 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.279722e-01 0.032 0 0
Signalling to RAS R-HSA-167044 9.279722e-01 0.032 0 0
Phenylalanine metabolism R-HSA-8964208 9.279722e-01 0.032 0 0
ERK/MAPK targets R-HSA-198753 9.279722e-01 0.032 0 0
Abacavir metabolism R-HSA-2161541 9.279722e-01 0.032 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.279722e-01 0.032 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.279722e-01 0.032 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.279722e-01 0.032 0 0
Circadian clock R-HSA-9909396 9.298300e-01 0.032 0 0
ER-Phagosome pathway R-HSA-1236974 9.299331e-01 0.032 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.310463e-01 0.031 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.320085e-01 0.031 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.330739e-01 0.030 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.339073e-01 0.030 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.349090e-01 0.029 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.349090e-01 0.029 0 0
Ribavirin ADME R-HSA-9755088 9.349090e-01 0.029 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.349090e-01 0.029 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.349090e-01 0.029 0 0
Attachment and Entry R-HSA-9694614 9.349090e-01 0.029 0 0
Cellular response to hypoxia R-HSA-1234174 9.364412e-01 0.029 0 0
NCAM1 interactions R-HSA-419037 9.365119e-01 0.028 0 0
Voltage gated Potassium channels R-HSA-1296072 9.365119e-01 0.028 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.365119e-01 0.028 0 0
Metabolism of folate and pterines R-HSA-196757 9.365119e-01 0.028 0 0
Translation R-HSA-72766 9.378832e-01 0.028 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.405297e-01 0.027 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.411781e-01 0.026 0 0
Fructose metabolism R-HSA-5652084 9.411781e-01 0.026 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.412333e-01 0.026 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.412333e-01 0.026 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.453975e-01 0.024 0 0
Nucleotide biosynthesis R-HSA-8956320 9.453975e-01 0.024 0 0
Hemostasis R-HSA-109582 9.460097e-01 0.024 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.462336e-01 0.024 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.468437e-01 0.024 0 0
Interleukin-20 family signaling R-HSA-8854691 9.468437e-01 0.024 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.468437e-01 0.024 0 0
Carnitine shuttle R-HSA-200425 9.468437e-01 0.024 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.468437e-01 0.024 0 0
Syndecan interactions R-HSA-3000170 9.468437e-01 0.024 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.474178e-01 0.023 1 0
Platelet degranulation R-HSA-114608 9.487180e-01 0.023 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.505456e-01 0.022 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.505456e-01 0.022 0 0
Glycogen metabolism R-HSA-8982491 9.505456e-01 0.022 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.505456e-01 0.022 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.505456e-01 0.022 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.519640e-01 0.021 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.519640e-01 0.021 0 0
Complex III assembly R-HSA-9865881 9.519640e-01 0.021 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.519640e-01 0.021 0 0
Neddylation R-HSA-8951664 9.524540e-01 0.021 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.545262e-01 0.020 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.545262e-01 0.020 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.545262e-01 0.020 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.545262e-01 0.020 0 0
Maturation of spike protein R-HSA-9694548 9.545262e-01 0.020 0 0
COPII-mediated vesicle transport R-HSA-204005 9.545932e-01 0.020 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.558184e-01 0.020 0 0
Hyaluronan degradation R-HSA-2160916 9.565913e-01 0.019 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.565913e-01 0.019 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.565913e-01 0.019 0 0
Formation of the nephric duct R-HSA-9830364 9.565913e-01 0.019 0 0
Laminin interactions R-HSA-3000157 9.565913e-01 0.019 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.575944e-01 0.019 0 0
Hedgehog 'on' state R-HSA-5632684 9.575944e-01 0.019 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.579119e-01 0.019 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.581990e-01 0.019 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.581990e-01 0.019 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.581990e-01 0.019 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.581990e-01 0.019 0 0
Translation of Structural Proteins R-HSA-9683701 9.581990e-01 0.019 0 0
Potassium Channels R-HSA-1296071 9.586606e-01 0.018 0 0
Dectin-2 family R-HSA-5621480 9.594566e-01 0.018 0 0
Cardiac conduction R-HSA-5576891 9.604223e-01 0.018 0 0
MET activates PTK2 signaling R-HSA-8874081 9.607731e-01 0.017 0 0
Abacavir ADME R-HSA-2161522 9.607731e-01 0.017 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.607731e-01 0.017 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.615866e-01 0.017 0 0
Signaling by BMP R-HSA-201451 9.645523e-01 0.016 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.645523e-01 0.016 0 0
Cristae formation R-HSA-8949613 9.645523e-01 0.016 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.645523e-01 0.016 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.645523e-01 0.016 0 0
Triglyceride biosynthesis R-HSA-75109 9.645523e-01 0.016 0 0
Synthesis of PE R-HSA-1483213 9.645523e-01 0.016 0 0
Insulin processing R-HSA-264876 9.645523e-01 0.016 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.647097e-01 0.016 0 0
Peroxisomal protein import R-HSA-9033241 9.651374e-01 0.015 0 0
Signaling by ERBB4 R-HSA-1236394 9.655318e-01 0.015 0 0
Amine ligand-binding receptors R-HSA-375280 9.675878e-01 0.014 0 0
Hedgehog 'off' state R-HSA-5610787 9.675904e-01 0.014 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.676880e-01 0.014 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.678544e-01 0.014 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.679676e-01 0.014 0 0
Insulin receptor recycling R-HSA-77387 9.679676e-01 0.014 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.679676e-01 0.014 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.700616e-01 0.013 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.702391e-01 0.013 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 9.702391e-01 0.013 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.702391e-01 0.013 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.720194e-01 0.012 0 0
Translation of Structural Proteins R-HSA-9694635 9.720679e-01 0.012 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.726807e-01 0.012 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.726807e-01 0.012 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.726807e-01 0.012 0 0
Neurotransmitter clearance R-HSA-112311 9.738432e-01 0.012 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.738432e-01 0.012 0 0
Interleukin-10 signaling R-HSA-6783783 9.739752e-01 0.011 0 0
Integrin cell surface interactions R-HSA-216083 9.739752e-01 0.011 0 0
Selenoamino acid metabolism R-HSA-2408522 9.757138e-01 0.011 0 0
Cargo concentration in the ER R-HSA-5694530 9.763637e-01 0.010 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.763637e-01 0.010 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.764408e-01 0.010 0 0
Intraflagellar transport R-HSA-5620924 9.769965e-01 0.010 0 0
Metal ion SLC transporters R-HSA-425410 9.769965e-01 0.010 0 0
Mitochondrial biogenesis R-HSA-1592230 9.779667e-01 0.010 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.786416e-01 0.009 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.788991e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.793954e-01 0.009 0 0
Immune System R-HSA-168256 9.795214e-01 0.009 0 0
Azathioprine ADME R-HSA-9748787 9.806488e-01 0.008 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.807000e-01 0.008 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.807000e-01 0.008 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.815888e-01 0.008 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.818100e-01 0.008 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.822574e-01 0.008 0 0
Meiotic recombination R-HSA-912446 9.822574e-01 0.008 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.822574e-01 0.008 0 0
Complex IV assembly R-HSA-9864848 9.822574e-01 0.008 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.825602e-01 0.008 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.837358e-01 0.007 0 0
Signaling by NOTCH2 R-HSA-1980145 9.842411e-01 0.007 0 0
eNOS activation R-HSA-203615 9.842411e-01 0.007 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.842411e-01 0.007 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.842411e-01 0.007 0 0
Gap junction assembly R-HSA-190861 9.842411e-01 0.007 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.842411e-01 0.007 0 0
RA biosynthesis pathway R-HSA-5365859 9.842411e-01 0.007 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.853779e-01 0.006 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.857602e-01 0.006 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.857602e-01 0.006 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.857602e-01 0.006 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.857856e-01 0.006 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.864117e-01 0.006 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.871329e-01 0.006 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.871329e-01 0.006 0 0
Triglyceride catabolism R-HSA-163560 9.871329e-01 0.006 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.873111e-01 0.006 0 0
Signaling by Hedgehog R-HSA-5358351 9.881298e-01 0.005 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.882822e-01 0.005 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.883733e-01 0.005 0 0
Degradation of AXIN R-HSA-4641257 9.883733e-01 0.005 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.883733e-01 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.883733e-01 0.005 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.883733e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.883733e-01 0.005 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.891816e-01 0.005 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.894854e-01 0.005 0 0
Leishmania phagocytosis R-HSA-9664417 9.894854e-01 0.005 0 0
Parasite infection R-HSA-9664407 9.894854e-01 0.005 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.894942e-01 0.005 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.894942e-01 0.005 0 0
Purine salvage R-HSA-74217 9.894942e-01 0.005 0 0
Leishmania infection R-HSA-9658195 9.898539e-01 0.004 0 0
Parasitic Infection Pathways R-HSA-9824443 9.898539e-01 0.004 0 0
Downstream TCR signaling R-HSA-202424 9.898919e-01 0.004 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.898919e-01 0.004 0 0
Iron uptake and transport R-HSA-917937 9.900143e-01 0.004 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.905072e-01 0.004 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.905072e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.905072e-01 0.004 0 0
RSV-host interactions R-HSA-9833110 9.909901e-01 0.004 1 1
Triglyceride metabolism R-HSA-8979227 9.912035e-01 0.004 0 0
Tryptophan catabolism R-HSA-71240 9.914225e-01 0.004 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.914225e-01 0.004 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.915476e-01 0.004 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.918060e-01 0.004 1 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.919489e-01 0.004 1 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.919489e-01 0.004 1 1
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.919489e-01 0.004 1 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.919489e-01 0.004 1 1
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.919489e-01 0.004 1 0
Signaling by Retinoic Acid R-HSA-5362517 9.919489e-01 0.004 0 0
G alpha (s) signalling events R-HSA-418555 9.923962e-01 0.003 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.925104e-01 0.003 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.929970e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.929970e-01 0.003 0 0
Mitochondrial protein degradation R-HSA-9837999 9.930553e-01 0.003 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.936723e-01 0.003 0 0
Depyrimidination R-HSA-73928 9.936723e-01 0.003 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.940370e-01 0.003 0 0
Infectious disease R-HSA-5663205 9.940849e-01 0.003 1 0
Formation of the cornified envelope R-HSA-6809371 9.944316e-01 0.002 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.944709e-01 0.002 0 0
Proteasome assembly R-HSA-9907900 9.948340e-01 0.002 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.948340e-01 0.002 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.951473e-01 0.002 1 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.951473e-01 0.002 1 1
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.951473e-01 0.002 1 0
Kidney development R-HSA-9830369 9.956878e-01 0.002 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.957826e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.959323e-01 0.002 0 0
O-linked glycosylation of mucins R-HSA-913709 9.960582e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.960582e-01 0.002 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.961894e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.961894e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.964460e-01 0.002 0 0
Pyruvate metabolism R-HSA-70268 9.965427e-01 0.002 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.967076e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.967076e-01 0.001 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.967275e-01 0.001 0 0
Adaptive Immune System R-HSA-1280218 9.967758e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.968318e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.969916e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.969916e-01 0.001 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.971893e-01 0.001 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.974605e-01 0.001 0 0
The phototransduction cascade R-HSA-2514856 9.974605e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.974605e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.979036e-01 0.001 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.981271e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.982616e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.982943e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.983078e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.984059e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.985449e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.985815e-01 0.001 1 1
Synthesis of PA R-HSA-1483166 9.986187e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.986245e-01 0.001 0 0
Sialic acid metabolism R-HSA-4085001 9.988725e-01 0.000 0 0
Regulation of beta-cell development R-HSA-186712 9.988725e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.988840e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.989020e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.989020e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.989814e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.990157e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.990797e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.990797e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.991621e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.992422e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.992489e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.993939e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.994996e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.994996e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.995977e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.996311e-01 0.000 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.996417e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.996667e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.996667e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996989e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.997280e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997701e-01 0.000 0 0
Disease R-HSA-1643685 9.997886e-01 0.000 1 0
SLC-mediated transmembrane transport R-HSA-425407 9.998003e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998092e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998262e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.998364e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998438e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.998794e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998794e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999111e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999381e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999436e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999487e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999632e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999674e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999709e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999794e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999836e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999885e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999894e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999898e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999906e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999907e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999920e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999923e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999929e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999930e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999936e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999952e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999962e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999969e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999973e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999984e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999984e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999990e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999991e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999991e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999994e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999997e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999998e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999999e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways