TAO1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A6NMY6 S164 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGS
A6NMY6 S26 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
A8MVM7 T470 Sugiyama None PESTDSGNTHQTHMEESKRFtLRSHSARQNSFKKQSKEIEN
O00165 S153 Sugiyama HAX1 HS1BP1 PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O00231 S298 Sugiyama PSMD11 RYAGRQTEALKCVAQASKNRsLADFEKALTDYRAELRDDPI
O00469 S83 Sugiyama PLOD2 NYTVKVLGQGEEWRGGDGINsIGGGQKVRLMKEVMEHYADQ
O14818 T152 Sugiyama PSMA7 HSPC LIVGFDFDGTPRLyQtDPsGtyHAWKANAIGRGAKSVREFL
O15127 T109 Sugiyama SCAMP2 QEELDRKAAELERKERELQNtVANLHVRQNNWPPLPSWCPV
O15143 S323 Sugiyama ARPC1B ARC41 QNLDKKAssEGGtAAGAGLDsLHKNsVsQIsVLsGGKAKCS
O15212 T107 Sugiyama PFDN6 HKE2 PFD6 IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG
O15226 T623 Sugiyama NKRF ITBA4 NRF KRDIEQIIRNYARsEsHtDLtFsRELTNDERKQIHQIAQKY
O43390 T137 Sugiyama HNRNPR HNRPR ESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O43615 T106 Sugiyama TIMM44 MIMT44 TIM44 DEARRLEEsDVLQEARRKyKtIESETVRTSEVLRKKLGELT
O43707 T443 Sugiyama ACTN4 sIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDL
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43707 T728 Sugiyama ACTN4 EQQHQLIQEALIFDNKHtNytMEHIRVGWEQLLTTIARTIN
O60231 T50 Sugiyama DHX16 DBP2 DDX16 KIAA0577 PRP2 LIGTAQRCTSAEEFVQRLRDtDTLDLsGPARDFALRLWNKV
O60488 T508 Sugiyama ACSL4 ACS4 FACL4 LACS4 VGAPLICCEIKLKDWQEGGytINDKPNPRGEIVIGGQNISM
O60506 T134 Sugiyama SYNCRIP HNRPQ NSAP1 DSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O60664 S254 Sugiyama PLIN3 M6PRBP1 TIP47 SyFVRLGsLSERLRQHAyEHsLGKLRATKQRAQEALLQLSQ
O60664 T328 Sugiyama PLIN3 M6PRBP1 TIP47 QLQGPEKEPPKPEQVESRALtMFRDIAQQLQATCTSLGSSI
O60716 T869 Sugiyama CTNND1 KIAA0384 FQVNLNNAsRsQssHsyDDstLPLIDRNQKsDKKPDREEIQ
O95071 T119 Sugiyama UBR5 EDD EDD1 HYD KIAA0896 GRTSRPGRTSDsPWFLsGSEtLGRLAGNTLGSRWSsGVGGs
O95817 T242 Sugiyama BAG3 BIS QPsFHQAQKTHyPAQQGEyQtHQPVyHKIQGDDWEPRPLRA
O95835 T1079 PSP LATS1 WARTS DtLNGWYKNGKHPEHAFYEFtFRRFFDDNGYPYNYPKPIEY
P00338 T275 Sugiyama LDHA PIG19 SVADLAESIMKNLRRVHPVstMIKGLYGIKDDVFLSVPCIL
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00558 T376 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 MDEVVKAtsRGCItIIGGGDtAtCCAKWNtEDKVsHVstGG
P00558 T378 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EVVKAtsRGCItIIGGGDtAtCCAKWNtEDKVsHVstGGGA
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04843 S276 Sugiyama RPN1 VLKGPFSRyDyQRQPDSGISsIRSFKTILPAAAQDVYYRDE
P05187 T181 Sugiyama ALPP PLAP AGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADVPASAR
P05187 T185 Sugiyama ALPP PLAP VGVVTTTRVQHAsPAGtyAHtVNRNWysDADVPASARQEGC
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05787 S410 Sugiyama KRT8 CYK8 TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06733 S291 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IsPDQLADLyKsFIKDyPVVsIEDPFDQDDWGAWQKFtAsA
P06733 S353 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 Y287 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 PsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDDWGAWQKF
P06748 S137 Sugiyama NPM1 NPM VAVEEDAEsEDEEEEDVKLLsIsGKRsAPGGGsKVPQKKVK
P06748 S260 Sugiyama NPM1 NPM GPssVEDIKAKMQAsIEKGGsLPKVEAKFINyVKNCFRMtD
P07195 T276 Sugiyama LDHB SVADLIESMLKNLSRIHPVStMVKGMYGIENEVFLSLPCIL
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 T117 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB RGyPtIKFFRNGDTASPKEytAGREADDIVNWLKKRTGPAA
P07355 S164 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGs
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07355 S26 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D EILCKLsLEGDHstPPsAyGsVKAytNFDAERDALNIEtAI
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 T1460 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 GKIVQIPFCGEIDCEDWIKKtTARDQDLEPGAPsMGAKSLC
P07858 T218 Sugiyama CTSB CPSB CTGEGDTPKCSKICEPGysPtyKQDKHYGYNSYSVSNSEKD
P07900 S169 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA TVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILH
P07900 T109 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LtIVDtGIGMTKADLINNLGtIAKSGtKAFMEALQAGADIS
P07900 T171 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILHLK
P07900 T645 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKDLVIL
P08238 S164 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB VVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILH
P08238 T104 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LtLVDtGIGMtKADLINNLGtIAKSGtKAFMEALQAGADIS
P08238 T166 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILHLK
P08238 T637 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MGyMMAKKHLEINPDHPIVEtLRQKAEADKNDKAVKDLVVL
P08238 T85 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LDsGKELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtI
P08238 T89 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P09211 T62 Sugiyama GSTP1 FAEES3 GST3 GsLKASCLyGQLPKFQDGDLtLyQsNtILRHLGRTLGLYGK
P09211 T68 Sugiyama GSTP1 FAEES3 GST3 CLyGQLPKFQDGDLtLyQsNtILRHLGRTLGLYGKDQQEAA
P09211 Y64 Sugiyama GSTP1 FAEES3 GST3 LKASCLyGQLPKFQDGDLtLyQsNtILRHLGRTLGLYGKDQ
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09874 T397 Sugiyama PARP1 ADPRT PPOL PAAVNSsAsADKPLSNMKILtLGKLSRNKDEVKAMIEKLGG
P09923 T178 Sugiyama ALPI AGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADMPASAR
P09923 T182 Sugiyama ALPI VGVVTTTRVQHAsPAGtyAHtVNRNWysDADMPASARQEGC
P09972 T123 Sugiyama ALDOC ALDC IVVGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGA
P09972 T124 Sugiyama ALDOC ALDC VVGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGAD
P09972 T125 Sugiyama ALDOC ALDC VGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGADF
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 S58 Sugiyama H1-4 H1F4 HIST1H1E PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P10809 S488 Sugiyama HSPD1 HSP60 IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P10809 T206 Sugiyama HSPD1 HSP60 IsDAMKKVGRKGVITVKDGKtLNDELEIIEGMKFDRGyIsP
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11586 T128 Sugiyama MTHFD1 MTHFC MTHFD SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P12268 S505 Sugiyama IMPDH2 IMPD2 SGELKFEKRtssAQVEGGVHsLHsyEKRLF___________
P12814 T709 Sugiyama ACTN1 EGDHQLIQEALIFDNKHtNytMEHIRVGWEQLLTTIARTIN
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 T34 Sugiyama EEF2 EF2 DKKANIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEt
P13639 T484 Sugiyama EEF2 EF2 VPCGNIVGLVGVDQFLVKtGtIttFEHAHNMRVMKFsVsPV
P13667 S379 Sugiyama PDIA4 ERP70 ERP72 QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH
P13667 T139 Sugiyama PDIA4 ERP70 ERP72 KIDAtsAsVLAsRFDVsGyPtIKILKKGQAVDyEGsRtQEE
P13667 T497 Sugiyama PDIA4 ERP70 ERP72 AILDEsGKKFAMEPEEFDsDtLREFVtAFKKGKLKPVIKSQ
P13674 T140 Sugiyama P4HA1 P4HA YFPNDEDQVGAAKALLRLQDtyNLDTDtIsKGNLPGVKHKS
P13674 T147 Sugiyama P4HA1 P4HA QVGAAKALLRLQDtyNLDTDtIsKGNLPGVKHKSFLTAEDC
P13987 T76 Sugiyama CD59 MIC11 MIN1 MIN2 MIN3 MSK21 AGLQVYNKCWKFEHCNFNDVtTRLRENELtyyCCKKDLCNF
P14618 S77 Sugiyama PKM OIP3 PK2 PK3 PKM2 sVEtLKEMIKsGMNVARLNFsHGtHEyHAEtIKNVRtAtEs
P14618 T80 Sugiyama PKM OIP3 PK2 PK3 PKM2 tLKEMIKsGMNVARLNFsHGtHEyHAEtIKNVRtAtEsFAs
P14618 T87 Sugiyama PKM OIP3 PK2 PK3 PKM2 sGMNVARLNFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRP
P14625 S523 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 RtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMAG
P15311 T299 Sugiyama EZR VIL2 RILQLCMGNHELYMRRRKPDtIEVQQMKAQAREEKHQKQLE
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15880 T230 Sugiyama RPS2 RPS4 PKKLLMMAGIDDCytsARGCtAtLGNFAKATFDAISKTysy
P15880 T232 Sugiyama RPS2 RPS4 KLLMMAGIDDCytsARGCtAtLGNFAKATFDAISKTysyLt
P16083 S80 Sugiyama NQO2 NMOR2 LSNPEVFNyGVEtHEAyKQRsLAsDITDEQKKVREADLVIF
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 S59 Sugiyama H1-3 H1F3 HIST1H1D PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 S58 Sugiyama H1-2 H1F2 HIST1H1C PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17812 T566 Sugiyama CTPS1 CTPS ASVGRLSHYLQKGCRLsPRDtysDRsGsssPDsEItELKFP
P17844 S520 Sugiyama DDX5 G17P1 HELR HLR1 GKRGGFNTFRDRENYDRGYssLLKRDFGAKTQNGVYSAANY
P19174 S672 Sugiyama PLCG1 PLC1 RLSEPVPQTNAHESKEWYHAsLTRAQAEHMLMRVPRDGAFL
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20290 T131 Sugiyama BTF3 NACB OK/SW-cl.8 NQGTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsIL
P20290 T133 Sugiyama BTF3 NACB OK/SW-cl.8 GTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsILNQ
P20674 T105 Sugiyama COX5A EPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYPY
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22314 T676 Sugiyama UBA1 A1S9T UBE1 FKQPAENVNQyLtDPKFVERtLRLAGtQPLEVLEAVQRSLV
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23381 T383 Sugiyama WARS1 IFI53 WARS WRS DtAKQIKTKVNKHAFsGGRDtIEEHRQFGGNCDVDVSFMYL
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P24752 T220 Sugiyama ACAT1 ACAT MAT TAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPVtV
P25205 S704 Sugiyama MCM3 DQEQKRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPK
P26038 T299 Sugiyama MSN RILALCMGNHELYMRRRKPDtIEVQQMKAQAREEKHQKQME
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26447 T15 Sugiyama S100A4 CAPL MTS1 ______MACPLEKALDVMVstFHKYSGKEGDKFKLNKSELK
P26639 T700 Sugiyama TARS1 TARS EKISGTVNIRTRDNKVHGERtIsEtIERLQQLKEFRSKQAE
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P26641 T302 Sugiyama EEF1G EF1G PRO1608 HLPKstFVLDEFKRKysNEDtLsVALPyFWEHFDKDGWSLW
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401 T346 Sugiyama TKT AKLGHAsDRIIALDGDtKNstFsEIFKKEHPDRFIECYIAE
P29401 T442 Sugiyama TKT GEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAA
P30086 S60 Sugiyama PEBP1 PBP PEBP VLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPK
P30086 T65 Sugiyama PEBP1 PBP PEBP QVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWH
P30101 S155 Sugiyama PDIA3 ERP57 ERP60 GRP58 ASVPLRTEEEFKKFISDKDAsIVGFFDDsFsEAHsEFLKAA
P31327 S1261 Sugiyama CPS1 NVQFLVKGNDVLVIECNLRAsRSFPFVsKTLGVDFIDVATK
P31327 S1268 Sugiyama CPS1 GNDVLVIECNLRAsRSFPFVsKTLGVDFIDVATKVMIGENV
P31327 T45 Sugiyama CPS1 AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P31942 S298 Sugiyama HNRNPH3 HNRPH3 GGsGMGGYGRDGMDNQGGyGsVGRMGMGNNysGGyGtPDGL
P31943 S285 Sugiyama HNRNPH1 HNRPH HNRPH1 NyCFsGMsDHRyGDGGstFQsttGHCVHMRGLPYRAtENDI
P31943 T282 Sugiyama HNRNPH1 HNRPH HNRPH1 RDLNyCFsGMsDHRyGDGGstFQsttGHCVHMRGLPYRAtE
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31948 S16 Sugiyama STIP1 _____MEQVNELKEKGNKALsVGNIDDALQCysEAIKLDPH
P31948 T145 Sugiyama STIP1 MNPFNMPNLYQKLESDPRtRtLLSDPTYRELIEQLRNKPSD
P31948 T243 Sugiyama STIP1 KQALKEKELGNDAYKKKDFDtALKHYDKAKELDPtNMtyIT
P31949 T33 Sugiyama S100A11 MLN70 S100C CIESLIAVFQKYAGKDGyNytLsKtEFLsFMNTELAAFTKN
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34932 T758 Sugiyama HSPA4 APG2 HSPH2 TNEAMEWMNNKLNLQNKQsLtMDPVVKSKEIEAKIKELTst
P35241 T299 Sugiyama RDX RILALCMGNHELYMRRRKPDtIEVQQMKAQAREEKHQKQLE
P35268 T62 Sugiyama RPL22 FLQERIKVNGKAGNLGGGVVtIERsKSKITVTSEVPFSKRY
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T41 Sugiyama GTF2F1 RAP74 NTTKKyNIMAFNAADKVNFAtWNQARLERDLSNKKIyQEEE
P35354 S448 Sugiyama PTGS2 COX2 PAVQKVSQASIDQSRQMKyQsFNEYRKRFMLKPYESFEELT
P35609 T716 Sugiyama ACTN2 EGDHQLIQEALVFDNKHtNytMEHIRVGWELLLTTIARTIN
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T271 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DISILEIQKGVFEVKSTNGDtFLGGEDFDQALLRHIVKEFK
P38646 T86 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43121 T100 Sugiyama MCAM MUC18 QGQSEPGEYEQRLsLQDRGAtLALtQVtPQDERIFLCQGKR
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46060 S24 Sugiyama RANGAP1 KIAA1835 SD EDIAKLAETLAKTQVAGGQLsFKGKSLKLNTAEDAKDVIKE
P46734 S218 SIGNOR MAP2K3 MEK3 MKK3 PRKMK3 SKK2 INKEGHVKMCDFGISGyLVDsVAKtMDAGCKPYMAPERINP
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46940 T1471 Sugiyama IQGAP1 KIAA0051 tLQEKKEKIQTGLKKLTELGtVDPKNKyQELINDIARDIRN
P48739 S165 Sugiyama PITPNB DRSQVEPADyKADEDPALFQsVKtKRGPLGPNWKKELANsP
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P49327 T1999 Sugiyama FASN FAS LLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFVVF
P49327 T262 Sugiyama FASN FAS VYATILNAGTNTDGFKEQGVtFPsGDIQEQLIRSLyQsAGV
P49368 T373 Sugiyama CCT3 CCTG TRIC5 KKIGDEYFTFITDCKDPKACtILLRGAsKEILSEVERNLQD
P49368 T459 Sugiyama CCT3 CCTG TRIC5 AVAQALEVIPRTLIQNCGAstIRLLtSLRAKHtQENCEtWG
P49411 T433 Sugiyama TUFM LRQPMILEKGQRFTLRDGNRtIGTGLVTNTLAMTEEEKNIK
P50990 T398 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 RGstDNLMDDIERAVDDGVNtFKVLTRDKRLVPGGGAtEIE
P51149 T168 Sugiyama RAB7A RAB7 NIPyFEtSAKEAINVEQAFQtIARNALKQETEVELyNEFPE
P51659 T191 Sugiyama HSD17B4 EDH17B4 SDR8C1 LLGLANSLAIEGRKsNIHCNtIAPNAGsRMTQTVMPEDLVE
P52565 S148 Sugiyama ARHGDIA GDIA1 YIQHTyRKGVKIDKtDyMVGsYGPRAEEyEFLtPVEEAPKG
P52888 S133 Sugiyama THOP1 SMREDVYQRIVWLQEKVQKDsLRPEAARYLERLIKLGRRNG
P52948 S683 Sugiyama NUP98 ADAR2 IAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEG
P53621 T821 Sugiyama COPA IMPLDTNWPLLTVSKGFFEGtIAsKGKGGALAADIDIDTVG
P54577 T130 Sugiyama YARS1 YARS VPLEKLKFIKGTDYQLSKEytLDVyRLSSVVTQHDSKKAGA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54868 T133 Sugiyama HMGCS2 LMERIQLPWDSVGRLEVGTEtIIDKSKAVKTVLMELFQDSG
P55010 T227 Sugiyama EIF5 ttEEAQRRRMDEISDHAKVLtLsDDLERtIEERVNILFDFV
P55060 S931 Sugiyama CSE1L CAS XPO2 KKEHDPVGQMVNNPKIHLAQsLHKLSTACPGRVPSMVSTSL
P55209 S69 Sugiyama NAP1L1 NRP LAALQERLDGLVEtPtGyIEsLPRVVKRRVNALKNLQVKCA
P55854 S27 Sugiyama SUMO3 SMT3A SMT3H1 KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P56192 S127 Sugiyama MARS1 MARS GKKGEDVLGSVRRALTHIDHsLSRQNCPFLAGETESLADIV
P57721 S59 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT EGGLNVTLTIRLLMHGKEVGsIIGKKGETVKKMREESGARI
P57723 S31 Sugiyama PCBP4 EPELSITLTLRMLMHGKEVGsIIGKKGETVKRIREQSSARI
P60174 S236 Sugiyama TPI1 TPI AtCKELASQPDVDGFLVGGAsLKPEFVDIINAKQ_______
P60174 T176 Sugiyama TPI1 TPI KDWSKVVLAyEPVWAIGtGKtATPQQAQEVHEKLRGWLKsN
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60660 T103 Sugiyama MYL6 QGtyEDyVEGLRVFDKEGNGtVMGAEIRHVLVtLGEKMTEE
P60660 T22 Sugiyama MYL6 CDFTEDQTAEFKEAFQLFDRtGDGKILysQCGDVMRALGQN
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T202 Sugiyama ACTB GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61163 T248 Sugiyama ACTR1A CTRN1 PQKDETLETEKAQyyLPDGstIEIGPSRFRAPELLFRPDLI
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61513 Y14 Sugiyama RPL37A _______MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQH
P61587 S210 PSP RND3 ARHE RHO8 RHOE FHVATLACVNKTNKNVKRNKsQRATKRIsHMPSRPELSAVA
P61587 S218 PSP RND3 ARHE RHO8 RHOE VNKTNKNVKRNKsQRATKRIsHMPSRPELSAVATDLRKDKA
P61587 S240 PSP RND3 ARHE RHO8 RHOE MPSRPELSAVATDLRKDKAKsCTVM________________
P61769 S75 Sugiyama B2M CDABP0092 HDCMA22P IEVDLLKNGERIEKVEHsDLsFsKDWSFYLLYYTEFTPTEK
P61916 T106 Sugiyama NPC2 HE1 PIPEPDGCKSGINCPIQKDKtySYLNKLPVKSEYPSIKLVV
P61956 S28 Sugiyama SUMO2 SMT3B SMT3H2 EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62081 T172 Sugiyama RPS7 RLIKVHLDKAQQNNVEHKVEtFsGVyKKLTGKDVNFEFPEF
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62750 T126 Sugiyama RPL23A KHQIKQAVKKLyDIDVAKVNtLIRPDGEKKAYVRLAPDyDA
P62826 S135 Sugiyama RAN ARA24 OK/SW-cl.81 IPIVLCGNKVDIKDRKVKAKsIVFHRKKNLQyyDIsAKSNy
P62826 T21 Sugiyama RAN ARA24 OK/SW-cl.81 MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63241 S100 Sugiyama EIF5A DVPNIKRNDFQLIGIQDGyLsLLQDSGEVREDLRLPEGDLG
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T202 Sugiyama ACTG1 ACTG GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 S21 Sugiyama EEF1A1 EEF1A EF1A LENG7 MGKEKtHINIVVIGHVDsGKstttGHLIyKCGGIDKRTIEK
P68104 T22 Sugiyama EEF1A1 EEF1A EF1A LENG7 GKEKtHINIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKF
P68104 T261 Sugiyama EEF1A1 EEF1A EF1A LENG7 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P68431 T46 Sugiyama H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
P78406 T256 Sugiyama RAE1 MRNP41 IEGRVAIHYINPPNPAKDNFtFKCHRSNGTNTSAPQDIyAV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P84243 T46 Sugiyama H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q00341 T729 Sugiyama HDLBP HBP VGL VEKAKKQLLHLAEEKQTKSFtVDIRAKPEYHKFLIGKGGGK
Q00610 T875 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 LKLLLPWLEARIHEGCEEPAtHNALAKIyIDsNNNPERFLR
Q00796 S73 Sugiyama SORD EYGRIGNFIVKKPMVLGHEAsGtVEKVGSSVKHLKPGDRVA
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01130 S208 Sugiyama SRSF2 SFRS2 RsRsPPPVsKRESKSRSRsKsPPKsPEEEGAVss_______
Q01581 T96 Sugiyama HMGCS1 HMGCS LMERNNLsyDCIGRLEVGTEtIIDKSKSVKTNLMQLFEESG
Q01844 S443 Sugiyama EWSR1 EWS AKAAVEWFDGKDFQGSKLKVsLARKKPPMNSMRGGLPPREG
Q04917 S145 Sugiyama YWHAH YWHA1 KMKGDYYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQM
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639 S21 Sugiyama EEF1A2 EEF1AL STN MGKEKtHINIVVIGHVDsGKstttGHLIyKCGGIDKRTIEK
Q05639 T22 Sugiyama EEF1A2 EEF1AL STN GKEKtHINIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKF
Q05639 T261 Sugiyama EEF1A2 EEF1AL STN PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06830 T183 Sugiyama PRDX1 PAGA PAGB TDPX2 FQFtDKHGEVCPAGWKPGsDtIKPDVQKSKEyFSKQK____
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q07666 T183 Sugiyama KHDRBS1 SAM68 PVKQYPKFNFVGKILGPQGNtIKRLQEETGAKISVLGKGsM
Q08AD1 T469 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 SVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLSFKPIN
Q08J23 T276 Sugiyama NSUN2 SAKI TRM4 RKEILFyDRILCDVPCSGDGtMRKNIDVWKKWTTLNSLQLH
Q12931 T494 Sugiyama TRAP1 HSP75 HSPC5 ALPsGQLtsLsEyASRMRAGtRNIyyLCAPNRHLAEHsPyy
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283 S67 Sugiyama G3BP1 G3BP sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13283 T241 Sugiyama G3BP1 G3BP ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13561 T315 Sugiyama DCTN2 DCTN50 KHKASVEDADTQSKVHQLyEtIQRWsPIASTLPELVQRLVT
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14103 T91 Sugiyama HNRNPD AUF1 HNRPD sKNEEDEGHsNssPRHsEAAtAQREEWKMFIGGLSWDTTKK
Q14152 S1188 Sugiyama EIF3A EIF3S10 KIAA0139 PWRPLVKPGGWREKEKAREEsWGPPRESRPsEEREWDREKE
Q14152 S1258 Sugiyama EIF3A EIF3S10 KIAA0139 RFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRERD
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152 T1379 Sugiyama EIF3A EIF3S10 KIAA0139 EKDREsLRRTKNEtDEDGWttVRR_________________
Q14203 T509 Sugiyama DCTN1 LDMAGARVREAQKRVEAAQEtVADyQQTIKKYRQLtAHLQD
Q14203 Y513 Sugiyama DCTN1 GARVREAQKRVEAAQEtVADyQQTIKKYRQLtAHLQDVNRE
Q14247 T68 Sugiyama CTTN EMS1 GHQEHINIHKLRENVFQEHQtLKEKELETGPKASHGyGGKF
Q14498 S117 Sugiyama RBM39 HCC1 RNPC2 sPysGPKFNSAIRGKIGLPHsIKLsRRRSRSKSPFRKDKsP
Q14568 S169 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 TVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILH
Q14568 T109 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LTIVDTGIGMTKADLINNLGtIAKSGtKAFMEALQAGADIS
Q14568 T171 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 ITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILHLK
Q14697 S52 Sugiyama GANAB G2AN KIAA0088 AVDRSNFKtCEEssFCKRQRsIRPGLsPyRALLDSLQLGPD
Q14974 T860 Sugiyama KPNB1 NTF97 RPMIHELLTEGRRSKTNKAKtLAtWATKELRKLKNQA____
Q14974 T863 Sugiyama KPNB1 NTF97 IHELLTEGRRSKTNKAKtLAtWATKELRKLKNQA_______
Q15084 S169 Sugiyama PDIA6 ERP5 P5 TXNDC7 GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15185 S85 Sugiyama PTGES3 P23 TEBP KHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVDFNN
Q15365 S27 Sugiyama PCBP1 ESGLNVTLTIRLLMHGKEVGsIIGKKGESVKRIREEsGARI
Q15366 S27 Sugiyama PCBP2 EGGLNVTLTIRLLMHGKEVGsIIGKKGESVKKMREESGARI
Q15369 T41 Sugiyama ELOC TCEB1 LISSDGHEFIVKREHALtsGtIKAMLSGPGQFAENETNEVN
Q15459 S508 Sugiyama SF3A1 SAP114 IGEEEIQKPEEKVTWDGHsGsMARTQQAAQANITLQEQIEA
Q15758 T532 Sugiyama SLC1A5 ASCT2 M7V1 RDR RDRC VPTEEGNPLLKHyRGPAGDAtVAsEKEsVM___________
Q16181 T426 PSP SEPTIN7 CDC10 SEPT7 DEKANWEAQQRILEQQNssRtLEKNKKKGKIF_________
Q16658 T239 Sugiyama FSCN1 FAN1 HSN SNL GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q16695 T46 Sugiyama H3-4 H3FT HIST3H3 ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q16775 T291 Sugiyama HAGH GLO2 HAGH1 PFMRVREKTVQQHAGETDPVttMRAVRREKDQFKMPRD___
Q16775 T292 Sugiyama HAGH GLO2 HAGH1 FMRVREKTVQQHAGETDPVttMRAVRREKDQFKMPRD____
Q4V328 S666 Sugiyama GRIPAP1 KIAA1167 EELVLsEMNsPSRtQtGDsssIssFsYREILREKEssAVPA
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF8 T104 Sugiyama HSP90AB2P HSP90BB LTLVDTGIGMTKADLINNLGtIAKFQDQTEYLEEMQVKEVV
Q5SSJ5 S225 Sugiyama HP1BP3 QALKRELNRGVIKQVKGKGAsGsFVVVQKSRKTPQKSRNRK
Q5VTE0 S21 Sugiyama EEF1A1P5 EEF1AL3 MGKEKtHINIVVIGHVDsGKstttGHLIyKCGGIDKRTIEK
Q5VTE0 T22 Sugiyama EEF1A1P5 EEF1AL3 GKEKtHINIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKF
Q5VTE0 T261 Sugiyama EEF1A1P5 EEF1AL3 PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6EEV6 S28 Sugiyama SUMO4 SMT3H4 EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6NXT2 T45 Sugiyama H3-5 H3F3C AARKSTPSTCGVKPHRyRPGtVALREIRRYQKstELLIRKL
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q71DI3 T46 Sugiyama H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D ARKsAPATGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7KZI7 T208 SIGNOR MARK2 EMK1 NIKIADFGFSNEFTFGNKLDtFCGsPPYAAPELFQGKKYDG
Q7RTP6 S1998 Sugiyama MICAL3 KIAA0819 KIAA1364 RLREREEDKDLEAAMLSKGFsLNWS________________
Q7RTV0 S53 Sugiyama PHF5A CDSyVRPCTLVRICDECNyGsyQGRCVICGGPGVSDAyyCK
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q86V81 T148 Sugiyama ALYREF ALY BEF THOC4 EFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQYNG
Q86XZ4 T192 Sugiyama SPATS2 SCR59 SPATA10 Nbla00526 LDRTGSMLQNGVSDFETKsLtMHSIHNSQQPRNAAKsLsRP
Q8N1F7 T121 Sugiyama NUP93 KIAA0095 FLKNEKDNALLsAIEESRKRtFGMAEEYHRESMLVEWEQVK
Q8N680 T264 Sugiyama ZBTB2 KIAA1483 ZNF437 MKRNGSFPKYYACHLCGRRFtLRSSLREHLQIHTGVPFTSS
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q92598 S65 Sugiyama HSPH1 HSP105 HSP110 KIAA0201 NRTIGVAAKNQQITHANNtVsNFKRFHGRAFNDPFIQKEKE
Q92598 T63 Sugiyama HSPH1 HSP105 HSP110 KIAA0201 SKNRTIGVAAKNQQITHANNtVsNFKRFHGRAFNDPFIQKE
Q93052 T325 Sugiyama LPP PGyGGRNDsDPtyGQQGHPNtWKREPGytPPGAGNQNPPGM
Q96D15 T124 Sugiyama RCN3 UNQ239/PRO272 AWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEELRNATYG
Q96QK1 T773 Sugiyama VPS35 MEM3 TCCCTA00141 DLPNLEssEEtEQINKHFHNtLEHLRLRREsPEsEGPIyEG
Q99426 T120 Sugiyama TBCB CG22 CKAP1 DVSRVEKytIsQEAyDQRQDtVRSFLKRsKLGRyNEEERAQ
Q99497 T140 Sugiyama PARK7 GSKVTtHPLAKDKMMNGGHytysENRVEKDGLILtSRGPGT
Q99497 Y139 Sugiyama PARK7 FGSKVTtHPLAKDKMMNGGHytysENRVEKDGLILtSRGPG
Q99584 S32 Sugiyama S100A13 SIETVVTTFFTFARQEGRKDsLsVNEFKELVTQQLPHLLKD
Q99584 S62 Sugiyama S100A13 VTQQLPHLLKDVGSLDEKMKsLDVNQDSELKFNEyWRLIGE
Q99613 T880 Sugiyama EIF3C EIF3S8 AEKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMR
Q99832 T98 Sugiyama CCT7 CCTH NIP7-1 TLVDIAKSQDAEVGDGTTsVtLLAAEFLKQVKPYVEEGLHP
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BS26 T293 Sugiyama ERP44 KIAA0573 TXNDC4 UNQ532/PRO1075 TESLEIFQNEVARQLISEKGtINFLHADCDKFRHPLLHIQK
Q9BUJ2 S512 Sugiyama HNRNPUL1 E1BAP5 HNRPUL1 IQIAARKKRNyILDQtNVyGsAQRRKMRPFEGFQRKAIVIC
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9H173 T125 Sugiyama SIL1 UNQ545/PRO836 QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9H4A3 T2245 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 TVNSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLS
Q9H4A3 T2247 Sugiyama WNK1 HSN2 KDP KIAA0344 PRKWNK1 NSQAAQAQPPAMTSSRKGtFtDDLHKLVDNWARDAMNLSGR
Q9HB71 T209 Sugiyama CACYBP S100A6BP SIP PNAS-107 EGLMNVLKKIyEDGDDDMKRtINKAWVESREKQAKGDTEF_
Q9HCN8 T196 Sugiyama SDF2L1 UNQ1941/PRO4424 EQYGSPIRGQHEVHGMPSANtHNtWKAMEGIFIKPSVEPSA
Q9HCN8 T199 Sugiyama SDF2L1 UNQ1941/PRO4424 GSPIRGQHEVHGMPSANtHNtWKAMEGIFIKPSVEPSAGHD
Q9NSE4 T1000 Sugiyama IARS2 MPTTKEKCPRCWKYTAESSDtLCPRCAEVVSGK________
Q9P0J1 T494 Sugiyama PDP1 PDP PPM2C EDQNAATHLIRHAVGNNEFGtVDHERLSKMLSLPEELARMY
Q9P0L2 T215 iPTMNet|EPSD MARK1 KIAA1477 MARK NIKIADFGFSNEFTVGNKLDtFCGsPPYAAPELFQGKKYDG
Q9P2B2 T497 Sugiyama PTGFRN CD9P1 EWIF FPRP KIAA1436 ERSKQRAQDGDFIFSKEHTDtFNFRIQRTTEEDRGNyyCVV
Q9UBQ5 T28 Sugiyama EIF3K EIF3S12 ARG134 HSPC029 MSTP001 PTD001 RANVGKLLKGIDRyNPENLAtLERYVETQAKENAyDLEANL
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UJW0 T141 Sugiyama DCTN4 VGMADKSVASGGWQEPENPHtQRMNKLIEyyQQLAQKEKVE
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35 S1648 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35 T2034 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 TRRRSRsRtPPAIRRRsRsRtPLLPRKRsRsRsPLAIRRRS
Q9UQ80 T200 Sugiyama PA2G4 EBP1 TPIEGMLSHQLKQHVIDGEKtIIQNPTDQQKKDHEKAEFEV
Q9Y2B0 T100 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 ELLEEICDRMKEyGEQIDPstHRKNYVRVVGRNGEssELDL
Q9Y2V2 S30 Sugiyama CARHSP1 QPPtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRt
Q9Y2V2 S32 Sugiyama CARHSP1 PtHQAsVGLLDtPRsRERsPsPLRGNVVPsPLPtRRtRtFs
Q9Y2V2 S52 Sugiyama CARHSP1 sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Q9Y3S1 T2157 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 GPQPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAA
Q9Y3S1 T2159 Sugiyama WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 QPALHVQAQVNNSNNKKGtFtDDLHKLVDEWTSKTVGAAQL
Q9Y450 S67 Sugiyama HBS1L HBS1 KIAA1038 KPsVEPVEEyDyEDLKEssNsVsNHQLSGFDQARLYsCLDH
Q9Y5L4 S57 Sugiyama TIMM13 TIM13B TIMM13A TIMM13B ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 4.473095e-09 8.349 1 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.474581e-08 7.831 0 0
Signaling by VEGF R-HSA-194138 6.308298e-08 7.200 0 0
MAPK family signaling cascades R-HSA-5683057 9.467511e-08 7.024 0 0
Axon guidance R-HSA-422475 5.575493e-07 6.254 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.076111e-06 5.512 0 0
Nervous system development R-HSA-9675108 3.312079e-06 5.480 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.248827e-06 5.372 0 0
Interleukin-12 signaling R-HSA-9020591 4.555842e-06 5.341 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.117481e-06 5.291 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.987690e-06 5.156 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.281877e-06 5.032 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.459814e-05 4.836 0 0
Interleukin-12 family signaling R-HSA-447115 2.133106e-05 4.671 0 0
Apoptotic execution phase R-HSA-75153 2.594615e-05 4.586 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.555206e-05 4.593 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.962489e-05 4.528 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.692343e-05 4.433 0 0
Signaling by Hippo R-HSA-2028269 5.164378e-05 4.287 0 0
L1CAM interactions R-HSA-373760 5.630395e-05 4.249 0 0
Cellular Senescence R-HSA-2559583 5.913912e-05 4.228 0 0
Signaling by Interleukins R-HSA-449147 7.897896e-05 4.102 0 0
Oncogene Induced Senescence R-HSA-2559585 9.503081e-05 4.022 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.211737e-04 3.917 0 0
Signaling by RAS mutants R-HSA-6802949 1.292019e-04 3.889 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.292019e-04 3.889 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.292019e-04 3.889 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.292019e-04 3.889 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.293764e-04 3.888 0 0
EPH-Ephrin signaling R-HSA-2682334 1.522584e-04 3.817 0 0
Signaling by ERBB2 R-HSA-1227986 1.938354e-04 3.713 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.176256e-04 3.662 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.509487e-04 3.455 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.394404e-04 3.469 0 0
Immune System R-HSA-168256 3.482283e-04 3.458 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.811211e-04 3.419 0 0
RAF activation R-HSA-5673000 4.257970e-04 3.371 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.939529e-04 3.226 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 6.640670e-04 3.178 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.717369e-04 3.173 0 0
RAB geranylgeranylation R-HSA-8873719 7.707708e-04 3.113 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.863202e-04 3.104 0 0
SOS-mediated signalling R-HSA-112412 9.408371e-04 3.026 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.888325e-04 3.005 0 0
Post NMDA receptor activation events R-HSA-438064 9.807611e-04 3.008 0 0
Semaphorin interactions R-HSA-373755 1.062345e-03 2.974 0 0
Diseases of programmed cell death R-HSA-9645723 1.069844e-03 2.971 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.143898e-03 2.942 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.143898e-03 2.942 0 0
Cell junction organization R-HSA-446728 1.163079e-03 2.934 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.165452e-03 2.934 0 0
Activation of RAS in B cells R-HSA-1169092 1.332646e-03 2.875 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.325570e-03 2.878 0 0
MAP2K and MAPK activation R-HSA-5674135 1.325570e-03 2.878 0 0
Ca-dependent events R-HSA-111996 1.502702e-03 2.823 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.637205e-03 2.786 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.568308e-03 2.805 0 0
Membrane Trafficking R-HSA-199991 1.770438e-03 2.752 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.744612e-03 2.758 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.699089e-03 2.770 0 0
Programmed Cell Death R-HSA-5357801 1.814477e-03 2.741 0 0
Apoptosis R-HSA-109581 2.105441e-03 2.677 0 0
Signal attenuation R-HSA-74749 2.433554e-03 2.614 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.433554e-03 2.614 0 0
RET signaling R-HSA-8853659 2.650115e-03 2.577 0 0
Calmodulin induced events R-HSA-111933 2.650115e-03 2.577 0 0
CaM pathway R-HSA-111997 2.650115e-03 2.577 0 0
Cell-Cell communication R-HSA-1500931 2.790979e-03 2.554 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.167189e-03 2.499 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.207510e-03 2.494 0 0
Polo-like kinase mediated events R-HSA-156711 3.207510e-03 2.494 0 0
IRS activation R-HSA-74713 3.442501e-03 2.463 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.699795e-03 2.432 0 0
Signaling by PTK6 R-HSA-8848021 3.699795e-03 2.432 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.679337e-03 2.434 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.038713e-03 2.394 0 0
IGF1R signaling cascade R-HSA-2428924 4.046150e-03 2.393 0 0
Rap1 signalling R-HSA-392517 3.835157e-03 2.416 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.101839e-03 2.387 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.417340e-03 2.355 0 0
Sensory processing of sound R-HSA-9659379 4.499059e-03 2.347 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.814540e-03 2.317 0 0
Interleukin-37 signaling R-HSA-9008059 4.690756e-03 2.329 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.981644e-03 2.303 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 4.981644e-03 2.303 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.059365e-03 2.296 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.346156e-03 2.272 0 0
Trafficking of AMPA receptors R-HSA-399719 5.339612e-03 2.272 0 0
Signaling by LTK R-HSA-9842663 5.059365e-03 2.296 0 0
Adaptive Immune System R-HSA-1280218 5.073184e-03 2.295 0 0
Mitotic Prophase R-HSA-68875 5.383561e-03 2.269 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.477235e-03 2.261 0 0
Signaling by ALK in cancer R-HSA-9700206 5.477235e-03 2.261 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.240849e-03 2.205 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 6.240849e-03 2.205 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.240849e-03 2.205 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.830817e-03 2.166 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.830817e-03 2.166 0 0
MHC class II antigen presentation R-HSA-2132295 6.419196e-03 2.193 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.830817e-03 2.166 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.538278e-03 2.185 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.140948e-03 2.146 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.283250e-03 2.138 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 7.368814e-03 2.133 0 0
HDL assembly R-HSA-8963896 7.590127e-03 2.120 0 0
ESR-mediated signaling R-HSA-8939211 7.632485e-03 2.117 0 0
DAG and IP3 signaling R-HSA-1489509 8.033095e-03 2.095 0 0
FOXO-mediated transcription R-HSA-9614085 8.095129e-03 2.092 0 0
Erythropoietin activates RAS R-HSA-9027284 9.119657e-03 2.040 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.119657e-03 2.040 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.838333e-03 2.054 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.119657e-03 2.040 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 9.146139e-03 2.039 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.547439e-03 2.020 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.547439e-03 2.020 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.547439e-03 2.020 0 0
GPER1 signaling R-HSA-9634597 1.062408e-02 1.974 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.083707e-02 1.965 0 0
PLC beta mediated events R-HSA-112043 9.978089e-03 2.001 0 0
Cellular responses to stimuli R-HSA-8953897 1.020639e-02 1.991 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.068170e-02 1.971 0 0
Long-term potentiation R-HSA-9620244 1.087452e-02 1.964 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.087452e-02 1.964 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.098416e-02 1.959 0 0
Diseases of cellular response to stress R-HSA-9675132 1.274189e-02 1.895 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.274189e-02 1.895 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.274189e-02 1.895 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.274189e-02 1.895 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.180398e-02 1.928 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.180398e-02 1.928 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.180398e-02 1.928 0 0
TRP channels R-HSA-3295583 1.232226e-02 1.909 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.275028e-02 1.894 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.275028e-02 1.894 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.389528e-02 1.857 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.389528e-02 1.857 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 1.389528e-02 1.857 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.389528e-02 1.857 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.389528e-02 1.857 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.586345e-02 1.800 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.486644e-02 1.828 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.486644e-02 1.828 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.486064e-02 1.828 0 0
G-protein mediated events R-HSA-112040 1.569541e-02 1.804 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.443244e-02 1.841 0 0
Signaling by ALK R-HSA-201556 1.443244e-02 1.841 0 0
Death Receptor Signaling R-HSA-73887 1.644974e-02 1.784 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.672036e-02 1.777 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.719191e-02 1.765 0 0
PKA activation in glucagon signalling R-HSA-164378 1.719191e-02 1.765 0 0
PKA activation R-HSA-163615 1.719191e-02 1.765 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.719191e-02 1.765 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.738965e-02 1.760 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.743442e-02 1.759 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.743442e-02 1.759 0 0
Axonal growth stimulation R-HSA-209563 1.936672e-02 1.713 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.832304e-02 1.737 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.832304e-02 1.737 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.940851e-02 1.712 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.940851e-02 1.712 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.973231e-02 1.705 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.901377e-02 1.721 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.973231e-02 1.705 0 0
Neuronal System R-HSA-112316 1.824111e-02 1.739 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.005534e-02 1.698 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.012830e-02 1.696 0 0
TNF signaling R-HSA-75893 2.042603e-02 1.690 0 0
Signaling by FGFR1 R-HSA-5654736 2.042603e-02 1.690 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.204385e-02 1.657 0 0
Interleukin-2 signaling R-HSA-9020558 2.219505e-02 1.654 0 0
Neutrophil degranulation R-HSA-6798695 2.246361e-02 1.649 0 0
Signaling by FGFR4 R-HSA-5654743 2.256606e-02 1.647 0 0
Defective pyroptosis R-HSA-9710421 2.256606e-02 1.647 0 0
TBC/RABGAPs R-HSA-8854214 2.256606e-02 1.647 0 0
NADE modulates death signalling R-HSA-205025 2.713089e-02 1.567 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.713089e-02 1.567 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.713089e-02 1.567 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.713089e-02 1.567 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.713089e-02 1.567 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.713089e-02 1.567 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.547635e-02 1.594 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.547635e-02 1.594 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.688094e-02 1.571 0 0
G0 and Early G1 R-HSA-1538133 2.378368e-02 1.624 0 0
Integrin signaling R-HSA-354192 2.619106e-02 1.582 0 0
Signalling to RAS R-HSA-167044 2.547635e-02 1.594 0 0
Signaling by FGFR3 R-HSA-5654741 2.653966e-02 1.576 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.547635e-02 1.594 0 0
Rab regulation of trafficking R-HSA-9007101 2.564086e-02 1.591 0 0
Cell-cell junction organization R-HSA-421270 2.404259e-02 1.619 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.715020e-02 1.566 0 0
Cellular responses to stress R-HSA-2262752 2.784038e-02 1.555 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.833105e-02 1.548 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.868732e-02 1.542 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.868732e-02 1.542 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.868732e-02 1.542 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.868991e-02 1.542 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.874869e-02 1.541 0 0
Recycling pathway of L1 R-HSA-437239 3.095174e-02 1.509 0 0
GRB2 events in EGFR signaling R-HSA-179812 3.116984e-02 1.506 0 0
MET activates RAS signaling R-HSA-8851805 3.116984e-02 1.506 0 0
Mitophagy R-HSA-5205647 3.145900e-02 1.502 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.191640e-02 1.496 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.432407e-02 1.464 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.432407e-02 1.464 0 0
Signalling to ERKs R-HSA-187687 3.432407e-02 1.464 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 4.135022e-02 1.384 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 4.135022e-02 1.384 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.592914e-02 1.445 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.579984e-02 1.446 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.970431e-02 1.401 0 0
Voltage gated Potassium channels R-HSA-1296072 4.052546e-02 1.392 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.022068e-02 1.396 0 0
Signaling by FGFR2 R-HSA-5654738 3.557051e-02 1.449 0 0
Insulin receptor signalling cascade R-HSA-74751 3.524038e-02 1.453 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.626767e-02 1.440 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.626767e-02 1.440 0 0
Potassium Channels R-HSA-1296071 4.057207e-02 1.392 0 0
Vesicle-mediated transport R-HSA-5653656 3.844726e-02 1.415 0 0
Muscle contraction R-HSA-397014 4.086872e-02 1.389 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.655810e-02 1.437 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.655810e-02 1.437 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.970431e-02 1.401 0 0
Neurodegenerative Diseases R-HSA-8863678 3.970431e-02 1.401 0 0
NrCAM interactions R-HSA-447038 3.592914e-02 1.445 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.592914e-02 1.445 0 0
Growth hormone receptor signaling R-HSA-982772 3.579984e-02 1.446 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.176576e-02 1.379 0 0
Regulation of KIT signaling R-HSA-1433559 4.176576e-02 1.379 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.296934e-02 1.367 0 0
HDMs demethylate histones R-HSA-3214842 4.384170e-02 1.358 0 0
Tight junction interactions R-HSA-420029 4.384170e-02 1.358 0 0
Interleukin-7 signaling R-HSA-1266695 4.384170e-02 1.358 0 0
Signaling by FGFR R-HSA-190236 4.463861e-02 1.350 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.478497e-02 1.349 0 0
Regulated Necrosis R-HSA-5218859 4.478497e-02 1.349 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.566292e-02 1.340 0 0
Phosphorylation of Emi1 R-HSA-176417 4.566292e-02 1.340 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.566292e-02 1.340 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.566292e-02 1.340 0 0
Meiosis R-HSA-1500620 4.641740e-02 1.333 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.641740e-02 1.333 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.765688e-02 1.322 0 0
p38MAPK events R-HSA-171007 4.765688e-02 1.322 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.821178e-02 1.317 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.886189e-02 1.311 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.916264e-02 1.308 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.012407e-02 1.300 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.624008e-02 1.250 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.624008e-02 1.250 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.393227e-02 1.268 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.058188e-02 1.218 0 0
Signaling by Erythropoietin R-HSA-9006335 6.270657e-02 1.203 0 0
DNA methylation R-HSA-5334118 6.270657e-02 1.203 0 0
mRNA Splicing R-HSA-72172 5.699398e-02 1.244 0 0
Killing mechanisms R-HSA-9664420 5.393227e-02 1.268 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.393227e-02 1.268 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.764597e-02 1.239 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.484456e-02 1.261 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.297661e-02 1.276 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.393227e-02 1.268 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.885835e-02 1.230 0 0
Pyroptosis R-HSA-5620971 5.764597e-02 1.239 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.876911e-02 1.231 0 0
Cell Cycle, Mitotic R-HSA-69278 6.199127e-02 1.208 1 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.624008e-02 1.250 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.281369e-02 1.277 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.764597e-02 1.239 0 0
Transmission across Chemical Synapses R-HSA-112315 6.117884e-02 1.213 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.296949e-02 1.201 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.882662e-02 1.230 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.624008e-02 1.250 0 0
Cardiac conduction R-HSA-5576891 5.097720e-02 1.293 0 0
Signaling by NTRKs R-HSA-166520 5.285981e-02 1.277 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.281369e-02 1.277 0 0
FLT3 Signaling R-HSA-9607240 5.484456e-02 1.261 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.359505e-02 1.197 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.378037e-02 1.195 0 0
Signaling by SCF-KIT R-HSA-1433557 6.727261e-02 1.172 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.757443e-02 1.170 0 0
MECP2 regulates transcription factors R-HSA-9022707 6.757443e-02 1.170 0 0
Ub-specific processing proteases R-HSA-5689880 6.794326e-02 1.168 0 0
DAP12 signaling R-HSA-2424491 6.799294e-02 1.168 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.799294e-02 1.168 0 0
Kinesins R-HSA-983189 7.110753e-02 1.148 0 0
Netrin-1 signaling R-HSA-373752 7.173517e-02 1.144 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.173517e-02 1.144 0 0
Stimuli-sensing channels R-HSA-2672351 7.183626e-02 1.144 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.350201e-02 1.134 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.495808e-02 1.125 0 0
Apoptotic factor-mediated response R-HSA-111471 7.495808e-02 1.125 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.495808e-02 1.125 0 0
Tie2 Signaling R-HSA-210993 7.495808e-02 1.125 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.504713e-02 1.125 0 0
Aquaporin-mediated transport R-HSA-445717 7.504713e-02 1.125 0 0
Innate Immune System R-HSA-168249 7.595768e-02 1.119 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.635607e-02 1.117 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.710860e-02 1.113 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.710860e-02 1.113 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.710860e-02 1.113 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 8.099302e-02 1.092 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 8.099302e-02 1.092 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 8.099302e-02 1.092 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 8.099302e-02 1.092 0 0
Type I hemidesmosome assembly R-HSA-446107 7.958547e-02 1.099 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.958547e-02 1.099 0 0
WNT mediated activation of DVL R-HSA-201688 9.219805e-02 1.035 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 9.219805e-02 1.035 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.053420e-01 0.977 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 9.068523e-02 1.042 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.902098e-02 1.004 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.902098e-02 1.004 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 9.115439e-02 1.040 0 0
p75NTR regulates axonogenesis R-HSA-193697 9.219805e-02 1.035 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.742219e-02 1.058 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.958547e-02 1.099 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.768769e-02 1.010 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 9.219805e-02 1.035 0 0
Regulation of CDH11 function R-HSA-9762292 1.053420e-01 0.977 0 0
PI3K/AKT activation R-HSA-198203 1.053420e-01 0.977 0 0
Adipogenesis R-HSA-9843745 9.797786e-02 1.009 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.132765e-02 1.039 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.742219e-02 1.058 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 9.219805e-02 1.035 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.768769e-02 1.010 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.170639e-02 1.038 0 0
Inhibition of PKR R-HSA-169131 8.099302e-02 1.092 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 9.219805e-02 1.035 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.053420e-01 0.977 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.132765e-02 1.039 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.699099e-02 1.061 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.811832e-02 1.008 0 0
Signaling by NOTCH R-HSA-157118 8.977295e-02 1.047 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.053420e-01 0.977 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.053420e-01 0.977 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.017809e-01 0.992 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.768769e-02 1.010 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.958547e-02 1.099 0 0
Deubiquitination R-HSA-5688426 7.983457e-02 1.098 0 0
Adherens junctions interactions R-HSA-418990 8.454331e-02 1.073 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.035720e-01 0.985 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 9.219805e-02 1.035 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.053420e-01 0.977 0 0
Co-stimulation by CD28 R-HSA-389356 9.115439e-02 1.040 0 0
Developmental Biology R-HSA-1266738 9.279893e-02 1.032 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.568183e-02 1.067 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.517356e-02 1.070 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.902098e-02 1.004 0 0
Signaling by Leptin R-HSA-2586552 1.053420e-01 0.977 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.059547e-01 0.975 0 0
HSF1-dependent transactivation R-HSA-3371571 1.073158e-01 0.969 0 0
Meiotic recombination R-HSA-912446 1.073158e-01 0.969 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 1.076521e-01 0.968 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 1.076521e-01 0.968 0 0
Assembly Of The HIV Virion R-HSA-175474 1.076521e-01 0.968 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.076521e-01 0.968 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 1.189988e-01 0.924 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 1.189988e-01 0.924 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.189988e-01 0.924 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.189988e-01 0.924 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.189988e-01 0.924 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.189988e-01 0.924 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 1.189988e-01 0.924 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.189988e-01 0.924 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.189988e-01 0.924 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.554350e-01 0.808 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.554350e-01 0.808 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.554350e-01 0.808 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.554350e-01 0.808 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.554350e-01 0.808 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.329673e-01 0.876 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.329673e-01 0.876 0 0
Formation of axial mesoderm R-HSA-9796292 1.619907e-01 0.791 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 1.165637e-01 0.933 0 0
Notch-HLH transcription pathway R-HSA-350054 1.165637e-01 0.933 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.165637e-01 0.933 0 0
Interleukin receptor SHC signaling R-HSA-912526 1.257404e-01 0.901 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 1.448278e-01 0.839 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.110048e-01 0.955 0 0
Meiotic synapsis R-HSA-1221632 1.188153e-01 0.925 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.315493e-01 0.881 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.154200e-01 0.938 0 0
Co-inhibition by PD-1 R-HSA-389948 1.415223e-01 0.849 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.367444e-01 0.864 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.475064e-01 0.831 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.157426e-01 0.937 0 0
Signaling by EGFR R-HSA-177929 1.370942e-01 0.863 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.329673e-01 0.876 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 1.179506e-01 0.928 0 0
Protein folding R-HSA-391251 1.444340e-01 0.840 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.473311e-01 0.832 0 0
Signaling by Insulin receptor R-HSA-74752 1.444340e-01 0.840 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.209946e-01 0.917 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.619907e-01 0.791 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.619907e-01 0.791 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.553058e-01 0.809 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.315493e-01 0.881 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.170936e-01 0.931 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.262180e-01 0.899 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.547074e-01 0.810 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.189521e-01 0.925 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.179506e-01 0.928 0 0
PCP/CE pathway R-HSA-4086400 1.597503e-01 0.797 0 0
NRAGE signals death through JNK R-HSA-193648 1.370942e-01 0.863 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.473311e-01 0.832 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.308197e-01 0.883 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.547074e-01 0.810 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.599394e-01 0.796 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.553058e-01 0.809 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.189988e-01 0.924 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.189988e-01 0.924 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.189521e-01 0.925 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.329673e-01 0.876 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.473311e-01 0.832 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.129948e-01 0.947 0 0
RNA Polymerase I Transcription R-HSA-73864 1.597503e-01 0.797 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.397269e-01 0.855 0 0
Signaling by NOTCH1 R-HSA-1980143 1.481697e-01 0.829 0 0
G alpha (12/13) signalling events R-HSA-416482 1.597503e-01 0.797 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.475064e-01 0.831 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.148935e-01 0.940 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.264934e-01 0.898 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.148935e-01 0.940 0 0
IRS-mediated signalling R-HSA-112399 1.434485e-01 0.843 0 0
Opioid Signalling R-HSA-111885 1.180379e-01 0.928 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.264934e-01 0.898 0 0
Selective autophagy R-HSA-9663891 1.203007e-01 0.920 0 0
Interleukin-2 family signaling R-HSA-451927 1.398645e-01 0.854 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.158809e-01 0.936 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.262180e-01 0.899 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.473311e-01 0.832 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.233394e-01 0.909 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 1.398645e-01 0.854 0 0
Diseases of Immune System R-HSA-5260271 1.398645e-01 0.854 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.189988e-01 0.924 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.158809e-01 0.936 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.475064e-01 0.831 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.619907e-01 0.791 0 0
Intra-Golgi traffic R-HSA-6811438 1.553058e-01 0.809 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.481697e-01 0.829 0 0
Autophagy R-HSA-9612973 1.238504e-01 0.907 0 0
Ion homeostasis R-HSA-5578775 1.370942e-01 0.863 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 1.547074e-01 0.810 0 0
Signaling by Hedgehog R-HSA-5358351 1.255048e-01 0.901 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.554350e-01 0.808 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.473311e-01 0.832 0 0
Hemostasis R-HSA-109582 1.274660e-01 0.895 0 0
PTEN Regulation R-HSA-6807070 1.292155e-01 0.889 0 0
Regulation of TP53 Activity R-HSA-5633007 1.379985e-01 0.860 0 0
Syndecan interactions R-HSA-3000170 1.257404e-01 0.901 0 0
Signaling by NOTCH4 R-HSA-9013694 1.369864e-01 0.863 0 0
Interleukin-1 family signaling R-HSA-446652 1.105514e-01 0.956 0 0
G1/S-Specific Transcription R-HSA-69205 1.110048e-01 0.955 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.370942e-01 0.863 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.619907e-01 0.791 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.473311e-01 0.832 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 1.444340e-01 0.840 0 0
Gene Silencing by RNA R-HSA-211000 1.352379e-01 0.869 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.632455e-01 0.787 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.632455e-01 0.787 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.632455e-01 0.787 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.632455e-01 0.787 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.632455e-01 0.787 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.632455e-01 0.787 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.632558e-01 0.787 0 0
G2/M Transition R-HSA-69275 1.636733e-01 0.786 0 0
Signaling by FGFR3 in disease R-HSA-5655332 1.647906e-01 0.783 0 0
Cellular response to chemical stress R-HSA-9711123 1.655911e-01 0.781 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.712947e-01 0.766 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.717088e-01 0.765 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 1.750618e-01 0.757 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.768973e-01 0.752 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.768973e-01 0.752 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.768973e-01 0.752 0 0
DAP12 interactions R-HSA-2172127 1.795792e-01 0.746 0 0
Regulation of insulin secretion R-HSA-422356 1.817211e-01 0.741 0 0
Toll-like Receptor Cascades R-HSA-168898 1.830468e-01 0.737 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.840250e-01 0.735 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.840250e-01 0.735 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.855060e-01 0.732 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.855060e-01 0.732 0 0
DARPP-32 events R-HSA-180024 1.855060e-01 0.732 0 0
Late endosomal microautophagy R-HSA-9615710 1.855060e-01 0.732 0 0
Regulation of gene expression in beta cells R-HSA-210745 1.855060e-01 0.732 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.873525e-01 0.727 0 0
HATs acetylate histones R-HSA-3214847 1.873525e-01 0.727 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.879383e-01 0.726 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.879383e-01 0.726 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.903665e-01 0.720 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 1.903665e-01 0.720 0 0
Classical Kir channels R-HSA-1296053 1.903665e-01 0.720 0 0
HCN channels R-HSA-1296061 2.238552e-01 0.650 0 0
Nucleotide catabolism defects R-HSA-9735786 2.238552e-01 0.650 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.238552e-01 0.650 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 2.238552e-01 0.650 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.238552e-01 0.650 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.238552e-01 0.650 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.238552e-01 0.650 0 0
Activation of AMPA receptors R-HSA-399710 2.559607e-01 0.592 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.559607e-01 0.592 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.559607e-01 0.592 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.559607e-01 0.592 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.559607e-01 0.592 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.867399e-01 0.543 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.867399e-01 0.543 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.867399e-01 0.543 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.867399e-01 0.543 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 2.867399e-01 0.543 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.162478e-01 0.500 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.162478e-01 0.500 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.162478e-01 0.500 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.920054e-01 0.717 0 0
Phosphorylation of the APC/C R-HSA-176412 2.072730e-01 0.683 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.445365e-01 0.463 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.445365e-01 0.463 0 0
Disinhibition of SNARE formation R-HSA-114516 3.445365e-01 0.463 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.445365e-01 0.463 0 0
FGFR3b ligand binding and activation R-HSA-190371 3.445365e-01 0.463 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.445365e-01 0.463 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.381337e-01 0.623 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.716566e-01 0.430 0 0
phospho-PLA2 pathway R-HSA-111995 3.716566e-01 0.430 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.716566e-01 0.430 0 0
Formation of annular gap junctions R-HSA-196025 3.716566e-01 0.430 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.847390e-01 0.546 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.287171e-01 0.641 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.398071e-01 0.620 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.622365e-01 0.581 0 0
FGFR2 alternative splicing R-HSA-6803529 3.310557e-01 0.480 0 0
mRNA 3'-end processing R-HSA-72187 2.494613e-01 0.603 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.614752e-01 0.442 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.077406e-01 0.512 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.191825e-01 0.496 0 0
HDACs deacetylate histones R-HSA-3214815 2.770452e-01 0.557 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.145017e-01 0.502 0 0
PKR-mediated signaling R-HSA-9833482 3.157356e-01 0.501 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.002424e-01 0.523 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.226611e-01 0.652 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.920054e-01 0.717 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.050152e-01 0.688 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.225219e-01 0.653 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.711743e-01 0.430 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.145050e-01 0.502 0 0
Passive transport by Aquaporins R-HSA-432047 2.226611e-01 0.652 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.191825e-01 0.496 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.999422e-01 0.523 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.225543e-01 0.653 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.225543e-01 0.653 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.770452e-01 0.557 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.436992e-01 0.613 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.523075e-01 0.453 0 0
Chromatin modifying enzymes R-HSA-3247509 2.806384e-01 0.552 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.559607e-01 0.592 0 0
PTK6 Expression R-HSA-8849473 3.445365e-01 0.463 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.534947e-01 0.452 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.981296e-01 0.703 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.157356e-01 0.501 0 0
M Phase R-HSA-68886 3.455295e-01 0.462 1 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.226611e-01 0.652 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.735501e-01 0.563 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.559607e-01 0.592 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 1.920054e-01 0.717 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.999422e-01 0.523 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.536576e-01 0.596 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.398071e-01 0.620 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.849132e-01 0.545 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.263333e-01 0.645 0 0
Regulation of CDH1 Function R-HSA-9764561 2.957000e-01 0.529 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.536576e-01 0.596 0 0
Chromatin organization R-HSA-4839726 3.505830e-01 0.455 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.587403e-01 0.445 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.559607e-01 0.592 0 0
Suppression of autophagy R-HSA-9636569 2.559607e-01 0.592 0 0
Ceramide signalling R-HSA-193681 2.867399e-01 0.543 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.867399e-01 0.543 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 3.162478e-01 0.500 0 0
Regulation by c-FLIP R-HSA-3371378 3.716566e-01 0.430 0 0
Budding and maturation of HIV virion R-HSA-162588 2.068537e-01 0.684 0 0
Deadenylation of mRNA R-HSA-429947 3.614752e-01 0.442 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.239478e-01 0.490 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.966293e-01 0.528 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.381337e-01 0.623 0 0
Cell Cycle R-HSA-1640170 1.901731e-01 0.721 1 0
Formation of definitive endoderm R-HSA-9823730 2.847390e-01 0.546 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.263333e-01 0.645 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.559607e-01 0.592 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.716566e-01 0.430 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.191825e-01 0.496 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.191825e-01 0.496 0 0
tRNA processing in the nucleus R-HSA-6784531 3.428830e-01 0.465 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.569054e-01 0.447 0 0
MTOR signalling R-HSA-165159 3.534947e-01 0.452 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.029358e-01 0.693 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.445365e-01 0.463 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.445365e-01 0.463 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.716566e-01 0.430 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.966775e-01 0.706 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.359669e-01 0.627 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.605259e-01 0.584 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.287171e-01 0.641 0 0
DNA Damage Bypass R-HSA-73893 2.225219e-01 0.653 0 0
RAS processing R-HSA-9648002 3.077406e-01 0.512 0 0
Cellular response to heat stress R-HSA-3371556 2.152434e-01 0.667 0 0
Regulation of BACH1 activity R-HSA-9708530 2.072730e-01 0.683 0 0
Smooth Muscle Contraction R-HSA-445355 2.585937e-01 0.587 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.523634e-01 0.453 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.514976e-01 0.599 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.598517e-01 0.585 0 0
Parasitic Infection Pathways R-HSA-9824443 2.944737e-01 0.531 0 0
Leishmania infection R-HSA-9658195 2.944737e-01 0.531 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.598517e-01 0.585 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.286376e-01 0.641 0 0
Macroautophagy R-HSA-1632852 3.523075e-01 0.453 0 0
Cyclin D associated events in G1 R-HSA-69231 3.762619e-01 0.425 0 0
G1 Phase R-HSA-69236 3.762619e-01 0.425 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.463239e-01 0.461 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.903665e-01 0.720 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.903665e-01 0.720 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.238552e-01 0.650 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.559607e-01 0.592 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.867399e-01 0.543 0 0
Activation of SMO R-HSA-5635838 2.072730e-01 0.683 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.445365e-01 0.463 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.445365e-01 0.463 0 0
LDL remodeling R-HSA-8964041 3.445365e-01 0.463 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.716566e-01 0.430 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.716566e-01 0.430 0 0
Dimerization of procaspase-8 R-HSA-69416 3.716566e-01 0.430 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.716566e-01 0.430 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.068537e-01 0.684 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.287171e-01 0.641 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.398071e-01 0.620 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.614752e-01 0.442 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.585937e-01 0.587 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.077406e-01 0.512 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.191825e-01 0.496 0 0
Hedgehog 'off' state R-HSA-5610787 1.930546e-01 0.714 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.068537e-01 0.684 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.867399e-01 0.543 0 0
Histamine receptors R-HSA-390650 1.903665e-01 0.720 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.162478e-01 0.500 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.226611e-01 0.652 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.287171e-01 0.641 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.963139e-01 0.528 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.226611e-01 0.652 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.077406e-01 0.512 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.903665e-01 0.720 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.238552e-01 0.650 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.559607e-01 0.592 0 0
Co-inhibition by BTLA R-HSA-9927353 2.559607e-01 0.592 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.559607e-01 0.592 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.867399e-01 0.543 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.445365e-01 0.463 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.445365e-01 0.463 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.445365e-01 0.463 0 0
Adrenoceptors R-HSA-390696 3.716566e-01 0.430 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.716566e-01 0.430 0 0
Translesion Synthesis by POLH R-HSA-110320 2.692021e-01 0.570 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.463239e-01 0.461 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.463239e-01 0.461 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.334092e-01 0.477 0 0
Signaling by WNT R-HSA-195721 1.947678e-01 0.710 0 0
G1/S Transition R-HSA-69206 2.433420e-01 0.614 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.145017e-01 0.502 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.145017e-01 0.502 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.145017e-01 0.502 0 0
Generic Transcription Pathway R-HSA-212436 3.402740e-01 0.468 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 2.509846e-01 0.600 0 0
FLT3 signaling in disease R-HSA-9682385 2.735501e-01 0.563 0 0
Reproduction R-HSA-1474165 2.785371e-01 0.555 0 0
Platelet sensitization by LDL R-HSA-432142 2.536576e-01 0.596 0 0
Glycolysis R-HSA-70171 1.930546e-01 0.714 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.559607e-01 0.592 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.867399e-01 0.543 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.867399e-01 0.543 0 0
VLDL assembly R-HSA-8866423 3.162478e-01 0.500 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.162478e-01 0.500 0 0
Synthesis of PG R-HSA-1483148 2.226611e-01 0.652 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.716566e-01 0.430 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.847390e-01 0.546 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.310557e-01 0.480 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.420695e-01 0.466 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.420695e-01 0.466 0 0
Signaling by ROBO receptors R-HSA-376176 3.387101e-01 0.470 0 0
Integration of energy metabolism R-HSA-163685 2.029358e-01 0.693 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.920054e-01 0.717 0 0
Ephrin signaling R-HSA-3928664 2.536576e-01 0.596 0 0
Signal transduction by L1 R-HSA-445144 2.847390e-01 0.546 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.002424e-01 0.523 0 0
Ion channel transport R-HSA-983712 2.677478e-01 0.572 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.975992e-01 0.704 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.912082e-01 0.718 0 0
Regulation of beta-cell development R-HSA-186712 3.145050e-01 0.502 0 0
LDL clearance R-HSA-8964038 3.310557e-01 0.480 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 2.559607e-01 0.592 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.867399e-01 0.543 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.920054e-01 0.717 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.920054e-01 0.717 0 0
Signaling by ERBB4 R-HSA-1236394 2.672750e-01 0.573 0 0
Downstream signal transduction R-HSA-186763 2.068537e-01 0.684 0 0
Triglyceride metabolism R-HSA-8979227 3.145050e-01 0.502 0 0
Glucose metabolism R-HSA-70326 3.186786e-01 0.497 0 0
Amyloid fiber formation R-HSA-977225 3.239318e-01 0.490 0 0
Triglyceride catabolism R-HSA-163560 2.735501e-01 0.563 0 0
PI Metabolism R-HSA-1483255 3.439243e-01 0.464 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.002424e-01 0.523 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.494613e-01 0.603 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.310557e-01 0.480 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.509846e-01 0.600 0 0
Interleukin-23 signaling R-HSA-9020933 3.716566e-01 0.430 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.156885e-01 0.501 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.614752e-01 0.442 0 0
Signaling by KIT in disease R-HSA-9669938 3.310557e-01 0.480 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.428830e-01 0.465 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.764932e-01 0.424 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.764932e-01 0.424 0 0
Formation of the nephric duct R-HSA-9830364 3.764932e-01 0.424 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.807875e-01 0.419 0 0
DNA Double Strand Break Response R-HSA-5693606 3.902384e-01 0.409 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.913628e-01 0.407 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.913628e-01 0.407 0 0
Myogenesis R-HSA-525793 3.913628e-01 0.407 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.913628e-01 0.407 0 0
Platelet degranulation R-HSA-114608 3.931151e-01 0.405 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.959038e-01 0.402 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.964392e-01 0.402 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.976561e-01 0.400 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.976561e-01 0.400 0 0
Gap junction degradation R-HSA-190873 3.976561e-01 0.400 0 0
CASP8 activity is inhibited R-HSA-5218900 3.976561e-01 0.400 0 0
ALK mutants bind TKIs R-HSA-9700645 3.976561e-01 0.400 0 0
Calcineurin activates NFAT R-HSA-2025928 3.976561e-01 0.400 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.976561e-01 0.400 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.976561e-01 0.400 0 0
ARMS-mediated activation R-HSA-170984 3.976561e-01 0.400 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.976561e-01 0.400 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.976561e-01 0.400 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.976561e-01 0.400 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.976561e-01 0.400 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.976561e-01 0.400 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.976561e-01 0.400 0 0
Interleukin-1 processing R-HSA-448706 3.976561e-01 0.400 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.976561e-01 0.400 0 0
Signaling by TGFBR3 R-HSA-9839373 3.988609e-01 0.399 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.006739e-01 0.397 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.033359e-01 0.394 0 0
Packaging Of Telomere Ends R-HSA-171306 4.060708e-01 0.391 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.060708e-01 0.391 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.100775e-01 0.387 0 0
Synthesis of PC R-HSA-1483191 4.100775e-01 0.387 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.147408e-01 0.382 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.184484e-01 0.378 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.206051e-01 0.376 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.206051e-01 0.376 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.206051e-01 0.376 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.225814e-01 0.374 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.225814e-01 0.374 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.225814e-01 0.374 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.225814e-01 0.374 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.225814e-01 0.374 0 0
Maturation of spike protein R-HSA-9683686 4.225814e-01 0.374 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.225814e-01 0.374 0 0
Pexophagy R-HSA-9664873 4.225814e-01 0.374 0 0
Josephin domain DUBs R-HSA-5689877 4.225814e-01 0.374 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.225814e-01 0.374 0 0
IRE1alpha activates chaperones R-HSA-381070 4.229586e-01 0.374 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.277882e-01 0.369 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.277882e-01 0.369 0 0
Degradation of CDH1 R-HSA-9766229 4.323086e-01 0.364 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.323086e-01 0.364 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.329763e-01 0.364 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.349549e-01 0.362 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.349549e-01 0.362 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.349549e-01 0.362 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.370888e-01 0.359 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.370888e-01 0.359 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 4.393278e-01 0.357 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.393278e-01 0.357 0 0
RNA Polymerase II Transcription R-HSA-73857 4.403467e-01 0.356 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.406554e-01 0.356 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.433097e-01 0.353 0 0
PI3K Cascade R-HSA-109704 4.433097e-01 0.353 0 0
Ca2+ pathway R-HSA-4086398 4.463460e-01 0.350 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.464766e-01 0.350 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.464766e-01 0.350 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.464766e-01 0.350 0 0
FGFR2b ligand binding and activation R-HSA-190377 4.464766e-01 0.350 0 0
Chylomicron assembly R-HSA-8963888 4.464766e-01 0.350 0 0
Synthesis of PI R-HSA-1483226 4.464766e-01 0.350 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 4.464766e-01 0.350 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.464766e-01 0.350 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.464766e-01 0.350 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.464766e-01 0.350 0 0
PECAM1 interactions R-HSA-210990 4.464766e-01 0.350 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.464766e-01 0.350 0 0
Prostanoid ligand receptors R-HSA-391908 4.464766e-01 0.350 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.464766e-01 0.350 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.474729e-01 0.349 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.477094e-01 0.349 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.491106e-01 0.348 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.491106e-01 0.348 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.491106e-01 0.348 0 0
Activation of BH3-only proteins R-HSA-114452 4.491106e-01 0.348 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.550461e-01 0.342 0 0
Signaling by FGFR in disease R-HSA-1226099 4.555555e-01 0.341 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.555555e-01 0.341 0 0
HCMV Late Events R-HSA-9610379 4.594960e-01 0.338 0 0
Phospholipid metabolism R-HSA-1483257 4.604294e-01 0.337 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.630636e-01 0.334 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.630636e-01 0.334 0 0
Cargo concentration in the ER R-HSA-5694530 4.630636e-01 0.334 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.636692e-01 0.334 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.647135e-01 0.333 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.650529e-01 0.332 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.693845e-01 0.328 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.693845e-01 0.328 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.693845e-01 0.328 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.693845e-01 0.328 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.693845e-01 0.328 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 4.693845e-01 0.328 0 0
NF-kB is activated and signals survival R-HSA-209560 4.693845e-01 0.328 0 0
Activation of RAC1 R-HSA-428540 4.693845e-01 0.328 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.693845e-01 0.328 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.693845e-01 0.328 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.757838e-01 0.323 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.757838e-01 0.323 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.757838e-01 0.323 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.768066e-01 0.322 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.768066e-01 0.322 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.768066e-01 0.322 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.814874e-01 0.317 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.903330e-01 0.310 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.903330e-01 0.310 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.903330e-01 0.310 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.903330e-01 0.310 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.903330e-01 0.310 0 0
G-protein beta:gamma signalling R-HSA-397795 4.903330e-01 0.310 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.913456e-01 0.309 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.913456e-01 0.309 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.913456e-01 0.309 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.913456e-01 0.309 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.913456e-01 0.309 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.913456e-01 0.309 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.913456e-01 0.309 0 0
Interleukin-15 signaling R-HSA-8983432 4.913456e-01 0.309 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.913456e-01 0.309 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.913456e-01 0.309 0 0
Regulation of IFNG signaling R-HSA-877312 4.913456e-01 0.309 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.913456e-01 0.309 0 0
Disorders of Nervous System Development R-HSA-9697154 4.913456e-01 0.309 0 0
Pervasive developmental disorders R-HSA-9005895 4.913456e-01 0.309 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 4.913456e-01 0.309 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 4.913456e-01 0.309 0 0
G alpha (z) signalling events R-HSA-418597 4.969395e-01 0.304 0 0
Signaling by NOTCH3 R-HSA-9012852 4.969395e-01 0.304 0 0
Striated Muscle Contraction R-HSA-390522 5.036373e-01 0.298 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.036373e-01 0.298 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.073552e-01 0.295 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 5.073552e-01 0.295 0 0
Signaling by MET R-HSA-6806834 5.096057e-01 0.293 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.104450e-01 0.292 0 0
Interleukin-1 signaling R-HSA-9020702 5.113130e-01 0.291 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.123990e-01 0.290 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.123990e-01 0.290 0 0
FGFR2c ligand binding and activation R-HSA-190375 5.123990e-01 0.290 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.123990e-01 0.290 0 0
FGFR4 ligand binding and activation R-HSA-190322 5.123990e-01 0.290 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.123990e-01 0.290 0 0
Frs2-mediated activation R-HSA-170968 5.123990e-01 0.290 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 5.123990e-01 0.290 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.123990e-01 0.290 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.123990e-01 0.290 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 5.123990e-01 0.290 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.123990e-01 0.290 0 0
FGFR3 mutant receptor activation R-HSA-2033514 5.123990e-01 0.290 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.123990e-01 0.290 0 0
Signaling by NOTCH2 R-HSA-1980145 5.167146e-01 0.287 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.167146e-01 0.287 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.167146e-01 0.287 0 0
Nuclear import of Rev protein R-HSA-180746 5.167146e-01 0.287 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.167146e-01 0.287 0 0
Synthesis of PA R-HSA-1483166 5.176574e-01 0.286 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.176574e-01 0.286 0 0
Prolactin receptor signaling R-HSA-1170546 5.325823e-01 0.274 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.325823e-01 0.274 0 0
cGMP effects R-HSA-418457 5.325823e-01 0.274 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.325823e-01 0.274 0 0
FGFR3c ligand binding and activation R-HSA-190372 5.325823e-01 0.274 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.325823e-01 0.274 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.325823e-01 0.274 0 0
Hydrolysis of LPC R-HSA-1483115 5.325823e-01 0.274 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.325823e-01 0.274 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.325823e-01 0.274 0 0
Signal regulatory protein family interactions R-HSA-391160 5.325823e-01 0.274 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.325823e-01 0.274 0 0
Zinc transporters R-HSA-435354 5.325823e-01 0.274 0 0
Metabolism of RNA R-HSA-8953854 5.339981e-01 0.272 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.344828e-01 0.272 0 0
Metabolism of non-coding RNA R-HSA-194441 5.379068e-01 0.269 0 0
snRNP Assembly R-HSA-191859 5.379068e-01 0.269 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.379068e-01 0.269 0 0
G alpha (q) signalling events R-HSA-416476 5.385906e-01 0.269 0 0
Mitotic Anaphase R-HSA-68882 5.386858e-01 0.269 1 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.393400e-01 0.268 0 0
GPVI-mediated activation cascade R-HSA-114604 5.421731e-01 0.266 0 0
HSF1 activation R-HSA-3371511 5.421731e-01 0.266 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.440151e-01 0.264 1 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.442535e-01 0.264 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 5.476105e-01 0.262 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.519313e-01 0.258 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.519313e-01 0.258 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 5.519313e-01 0.258 0 0
p75NTR signals via NF-kB R-HSA-193639 5.519313e-01 0.258 0 0
FGFR3 ligand binding and activation R-HSA-190239 5.519313e-01 0.258 0 0
Translesion synthesis by REV1 R-HSA-110312 5.519313e-01 0.258 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.519313e-01 0.258 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.519313e-01 0.258 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 5.519313e-01 0.258 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.519313e-01 0.258 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.519313e-01 0.258 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.519313e-01 0.258 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.519313e-01 0.258 0 0
Protein methylation R-HSA-8876725 5.519313e-01 0.258 0 0
S Phase R-HSA-69242 5.525382e-01 0.258 0 0
G2/M Checkpoints R-HSA-69481 5.544512e-01 0.256 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.545484e-01 0.256 0 0
Cleavage of the damaged purine R-HSA-110331 5.545484e-01 0.256 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.576617e-01 0.254 0 0
MAP kinase activation R-HSA-450294 5.576617e-01 0.254 0 0
Gene expression (Transcription) R-HSA-74160 5.653383e-01 0.248 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.666848e-01 0.247 0 0
Purine salvage R-HSA-74217 5.666848e-01 0.247 0 0
Depurination R-HSA-73927 5.666848e-01 0.247 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.666848e-01 0.247 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.673469e-01 0.246 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.673469e-01 0.246 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.673469e-01 0.246 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.673469e-01 0.246 0 0
Signaling by PDGF R-HSA-186797 5.673469e-01 0.246 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.693906e-01 0.245 0 0
Translesion synthesis by POLI R-HSA-5656121 5.704805e-01 0.244 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.704805e-01 0.244 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 5.704805e-01 0.244 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.704805e-01 0.244 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.704805e-01 0.244 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.704805e-01 0.244 0 0
Prolonged ERK activation events R-HSA-169893 5.704805e-01 0.244 0 0
Differentiation of T cells R-HSA-9945266 5.704805e-01 0.244 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.704805e-01 0.244 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.704805e-01 0.244 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.704805e-01 0.244 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 5.704805e-01 0.244 0 0
Negative regulation of FLT3 R-HSA-9706369 5.704805e-01 0.244 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.704805e-01 0.244 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.704805e-01 0.244 0 0
Attachment and Entry R-HSA-9678110 5.704805e-01 0.244 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.704805e-01 0.244 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.719399e-01 0.243 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.769008e-01 0.239 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.769008e-01 0.239 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.785810e-01 0.238 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 5.785810e-01 0.238 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.785810e-01 0.238 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.792418e-01 0.237 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.836137e-01 0.234 0 0
DNA Replication R-HSA-69306 5.836137e-01 0.234 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.857128e-01 0.232 0 0
Peptide chain elongation R-HSA-156902 5.857128e-01 0.232 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.882628e-01 0.230 0 0
Translesion synthesis by POLK R-HSA-5655862 5.882628e-01 0.230 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.882628e-01 0.230 0 0
Scavenging by Class B Receptors R-HSA-3000471 5.882628e-01 0.230 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.882628e-01 0.230 0 0
Galactose catabolism R-HSA-70370 5.882628e-01 0.230 0 0
Disorders of Developmental Biology R-HSA-9675151 5.882628e-01 0.230 0 0
HCMV Infection R-HSA-9609646 5.884448e-01 0.230 0 0
Attenuation phase R-HSA-3371568 5.902359e-01 0.229 0 0
Aggrephagy R-HSA-9646399 5.902359e-01 0.229 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.902359e-01 0.229 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.902359e-01 0.229 0 0
Glycogen metabolism R-HSA-8982491 5.902359e-01 0.229 0 0
PPARA activates gene expression R-HSA-1989781 5.957451e-01 0.225 0 0
Influenza Infection R-HSA-168255 5.973369e-01 0.224 0 0
FCERI mediated MAPK activation R-HSA-2871796 6.007422e-01 0.221 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.009859e-01 0.221 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.016493e-01 0.221 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.016493e-01 0.221 0 0
Maturation of spike protein R-HSA-9694548 6.016493e-01 0.221 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.016493e-01 0.221 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.016701e-01 0.221 0 0
Base Excision Repair R-HSA-73884 6.016701e-01 0.221 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.053100e-01 0.218 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.053100e-01 0.218 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.053100e-01 0.218 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.053100e-01 0.218 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.053100e-01 0.218 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.053100e-01 0.218 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.053100e-01 0.218 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.076943e-01 0.216 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.095083e-01 0.215 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.128211e-01 0.213 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.172511e-01 0.210 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.216524e-01 0.206 0 0
GAB1 signalosome R-HSA-180292 6.216524e-01 0.206 0 0
Activated point mutants of FGFR2 R-HSA-2033519 6.216524e-01 0.206 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.216524e-01 0.206 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.216524e-01 0.206 0 0
Mismatch Repair R-HSA-5358508 6.216524e-01 0.206 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.216524e-01 0.206 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.216524e-01 0.206 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.216524e-01 0.206 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.226371e-01 0.206 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.230423e-01 0.205 0 0
Activation of GABAB receptors R-HSA-991365 6.237517e-01 0.205 0 0
GABA B receptor activation R-HSA-977444 6.237517e-01 0.205 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.237517e-01 0.205 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.237517e-01 0.205 0 0
Depyrimidination R-HSA-73928 6.237517e-01 0.205 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.248974e-01 0.204 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.313682e-01 0.200 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.324647e-01 0.199 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.344419e-01 0.198 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 6.351527e-01 0.197 0 0
Interferon alpha/beta signaling R-HSA-909733 6.351527e-01 0.197 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.373190e-01 0.196 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.373190e-01 0.196 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.373190e-01 0.196 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.373190e-01 0.196 0 0
Regulation of signaling by CBL R-HSA-912631 6.373190e-01 0.196 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.373190e-01 0.196 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.373190e-01 0.196 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 6.373190e-01 0.196 0 0
Other interleukin signaling R-HSA-449836 6.373190e-01 0.196 0 0
The NLRP3 inflammasome R-HSA-844456 6.373190e-01 0.196 0 0
Ribosome-associated quality control R-HSA-9948299 6.385948e-01 0.195 0 0
DNA Repair R-HSA-73894 6.390691e-01 0.194 0 0
Interleukin-17 signaling R-HSA-448424 6.399585e-01 0.194 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.446638e-01 0.191 0 0
RMTs methylate histone arginines R-HSA-3214858 6.448930e-01 0.191 0 0
Gap junction trafficking R-HSA-190828 6.448930e-01 0.191 0 0
Amine ligand-binding receptors R-HSA-375280 6.448930e-01 0.191 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.472478e-01 0.189 0 0
Hedgehog 'on' state R-HSA-5632684 6.484073e-01 0.188 0 0
Developmental Cell Lineages R-HSA-9734767 6.493975e-01 0.187 0 0
Leishmania phagocytosis R-HSA-9664417 6.506711e-01 0.187 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.506711e-01 0.187 0 0
Parasite infection R-HSA-9664407 6.506711e-01 0.187 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 6.523379e-01 0.186 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.523379e-01 0.186 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 6.523379e-01 0.186 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.523379e-01 0.186 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.523379e-01 0.186 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.523379e-01 0.186 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.523379e-01 0.186 0 0
Glycogen synthesis R-HSA-3322077 6.523379e-01 0.186 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.544991e-01 0.184 0 0
Eukaryotic Translation Termination R-HSA-72764 6.544991e-01 0.184 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.551064e-01 0.184 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.551064e-01 0.184 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.613321e-01 0.180 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.648792e-01 0.177 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.650839e-01 0.177 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.650839e-01 0.177 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.650839e-01 0.177 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.667357e-01 0.176 0 0
FGFR2 ligand binding and activation R-HSA-190241 6.667357e-01 0.176 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.667357e-01 0.176 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.667357e-01 0.176 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.667357e-01 0.176 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.667357e-01 0.176 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.683172e-01 0.175 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.686997e-01 0.175 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.739567e-01 0.171 1 1
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.805381e-01 0.167 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.805381e-01 0.167 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.805381e-01 0.167 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.805381e-01 0.167 0 0
Glutathione synthesis and recycling R-HSA-174403 6.805381e-01 0.167 0 0
Attachment and Entry R-HSA-9694614 6.805381e-01 0.167 0 0
Ribavirin ADME R-HSA-9755088 6.805381e-01 0.167 0 0
Centrosome maturation R-HSA-380287 6.807826e-01 0.167 0 0
Protein ubiquitination R-HSA-8852135 6.807826e-01 0.167 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.807826e-01 0.167 0 0
Intraflagellar transport R-HSA-5620924 6.843392e-01 0.165 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.843392e-01 0.165 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.857504e-01 0.164 0 0
HCMV Early Events R-HSA-9609690 6.868884e-01 0.163 0 0
Neddylation R-HSA-8951664 6.885353e-01 0.162 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.899269e-01 0.161 0 0
G alpha (s) signalling events R-HSA-418555 6.909280e-01 0.161 0 0
Formation of the cornified envelope R-HSA-6809371 6.923019e-01 0.160 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.927974e-01 0.159 0 0
Gap junction trafficking and regulation R-HSA-157858 6.936218e-01 0.159 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.937696e-01 0.159 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.937696e-01 0.159 0 0
mTORC1-mediated signalling R-HSA-166208 6.937696e-01 0.159 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.937696e-01 0.159 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.937696e-01 0.159 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 6.937696e-01 0.159 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.937696e-01 0.159 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.937696e-01 0.159 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.937696e-01 0.159 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.937696e-01 0.159 0 0
Selenocysteine synthesis R-HSA-2408557 6.958826e-01 0.157 0 0
Leishmania parasite growth and survival R-HSA-9664433 7.011175e-01 0.154 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 7.011175e-01 0.154 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.024233e-01 0.153 0 0
Integrin cell surface interactions R-HSA-216083 7.035752e-01 0.153 0 0
Formation of the ureteric bud R-HSA-9830674 7.064539e-01 0.151 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.064539e-01 0.151 0 0
Viral mRNA Translation R-HSA-192823 7.088619e-01 0.149 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.110843e-01 0.148 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.115102e-01 0.148 0 0
The phototransduction cascade R-HSA-2514856 7.115102e-01 0.148 0 0
Potential therapeutics for SARS R-HSA-9679191 7.125415e-01 0.147 0 0
SARS-CoV Infections R-HSA-9679506 7.128027e-01 0.147 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.153200e-01 0.145 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.186135e-01 0.144 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.186135e-01 0.144 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.186135e-01 0.144 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.198886e-01 0.143 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 7.198886e-01 0.143 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.201219e-01 0.143 0 0
Neurexins and neuroligins R-HSA-6794361 7.201219e-01 0.143 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.201219e-01 0.143 0 0
RSV-host interactions R-HSA-9833110 7.214335e-01 0.142 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.251047e-01 0.140 0 0
Interferon Signaling R-HSA-913531 7.270328e-01 0.138 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.302702e-01 0.137 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.302702e-01 0.137 0 0
G protein gated Potassium channels R-HSA-1296059 7.302702e-01 0.137 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.302702e-01 0.137 0 0
TGFBR3 expression R-HSA-9839394 7.302702e-01 0.137 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.302702e-01 0.137 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.302702e-01 0.137 0 0
Laminin interactions R-HSA-3000157 7.302702e-01 0.137 0 0
Platelet homeostasis R-HSA-418346 7.335990e-01 0.135 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.335990e-01 0.135 0 0
rRNA processing R-HSA-72312 7.366545e-01 0.133 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.366955e-01 0.133 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.366955e-01 0.133 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.380452e-01 0.132 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.387665e-01 0.131 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.395302e-01 0.131 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.414446e-01 0.130 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.414446e-01 0.130 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.414446e-01 0.130 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.446642e-01 0.128 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.453610e-01 0.128 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.453610e-01 0.128 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 7.521568e-01 0.124 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.521568e-01 0.124 0 0
Cristae formation R-HSA-8949613 7.521568e-01 0.124 0 0
Triglyceride biosynthesis R-HSA-75109 7.521568e-01 0.124 0 0
Insulin processing R-HSA-264876 7.521568e-01 0.124 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.521568e-01 0.124 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.521568e-01 0.124 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.524253e-01 0.124 0 0
Cellular response to starvation R-HSA-9711097 7.525535e-01 0.123 0 0
Interferon gamma signaling R-HSA-877300 7.572577e-01 0.121 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.582429e-01 0.120 0 0
GPCR downstream signalling R-HSA-388396 7.605054e-01 0.119 0 0
Insulin receptor recycling R-HSA-77387 7.624258e-01 0.118 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.624258e-01 0.118 0 0
Inflammasomes R-HSA-622312 7.624258e-01 0.118 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.644689e-01 0.117 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.673388e-01 0.115 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.676900e-01 0.115 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.676900e-01 0.115 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.722699e-01 0.112 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 7.722699e-01 0.112 0 0
Platelet calcium homeostasis R-HSA-418360 7.722699e-01 0.112 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.722699e-01 0.112 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.744984e-01 0.111 0 0
GABA receptor activation R-HSA-977443 7.814649e-01 0.107 0 0
tRNA Aminoacylation R-HSA-379724 7.814649e-01 0.107 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.817066e-01 0.107 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.817066e-01 0.107 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.817066e-01 0.107 0 0
Neurotransmitter clearance R-HSA-112311 7.817066e-01 0.107 0 0
Activation of the pre-replicative complex R-HSA-68962 7.817066e-01 0.107 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.817066e-01 0.107 0 0
ER-Phagosome pathway R-HSA-1236974 7.823677e-01 0.107 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.882418e-01 0.103 0 0
Nucleotide salvage R-HSA-8956321 7.882418e-01 0.103 0 0
Collagen degradation R-HSA-1442490 7.882418e-01 0.103 0 0
Post-translational protein modification R-HSA-597592 7.889135e-01 0.103 0 0
Mitotic Prometaphase R-HSA-68877 7.906549e-01 0.102 1 1
EGFR downregulation R-HSA-182971 7.907529e-01 0.102 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.907529e-01 0.102 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.907529e-01 0.102 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.948331e-01 0.100 0 0
Heme signaling R-HSA-9707616 7.948331e-01 0.100 0 0
Mitochondrial protein import R-HSA-1268020 7.948331e-01 0.100 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.982742e-01 0.098 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.982742e-01 0.098 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.994248e-01 0.097 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.012423e-01 0.096 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.044709e-01 0.094 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.050033e-01 0.094 0 0
Ion transport by P-type ATPases R-HSA-936837 8.074733e-01 0.093 0 0
Homology Directed Repair R-HSA-5693538 8.077185e-01 0.093 0 0
Nuclear RNA decay R-HSA-9930044 8.077379e-01 0.093 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.077379e-01 0.093 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.077379e-01 0.093 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.077379e-01 0.093 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.077379e-01 0.093 0 0
Collagen formation R-HSA-1474290 8.147965e-01 0.089 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.157069e-01 0.088 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.157069e-01 0.088 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.157069e-01 0.088 0 0
Heme degradation R-HSA-189483 8.157069e-01 0.088 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.212069e-01 0.086 0 0
eNOS activation R-HSA-203615 8.233460e-01 0.084 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.233460e-01 0.084 0 0
Gap junction assembly R-HSA-190861 8.233460e-01 0.084 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.233460e-01 0.084 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.233460e-01 0.084 0 0
Signal amplification R-HSA-392518 8.233460e-01 0.084 0 0
Kidney development R-HSA-9830369 8.251343e-01 0.083 0 0
Cell Cycle Checkpoints R-HSA-69620 8.294651e-01 0.081 1 0
Acyl chain remodelling of PE R-HSA-1482839 8.306689e-01 0.081 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.306689e-01 0.081 0 0
PERK regulates gene expression R-HSA-381042 8.306689e-01 0.081 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.306689e-01 0.081 0 0
Host Interactions of HIV factors R-HSA-162909 8.339057e-01 0.079 0 0
Telomere Maintenance R-HSA-157579 8.340644e-01 0.079 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.376887e-01 0.077 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.376887e-01 0.077 0 0
Glycosphingolipid transport R-HSA-9845576 8.376887e-01 0.077 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.376887e-01 0.077 0 0
Degradation of DVL R-HSA-4641258 8.444179e-01 0.073 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.444179e-01 0.073 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.444179e-01 0.073 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.464134e-01 0.072 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.464134e-01 0.072 0 0
Metabolism of cofactors R-HSA-8978934 8.464134e-01 0.072 0 0
MET promotes cell motility R-HSA-8875878 8.508685e-01 0.070 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.508685e-01 0.070 0 0
Elastic fibre formation R-HSA-1566948 8.508685e-01 0.070 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.508685e-01 0.070 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.508685e-01 0.070 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.513525e-01 0.070 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.557025e-01 0.068 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.561465e-01 0.067 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.570521e-01 0.067 0 0
Stabilization of p53 R-HSA-69541 8.570521e-01 0.067 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.570521e-01 0.067 0 0
ROS and RNS production in phagocytes R-HSA-1222556 8.607989e-01 0.065 0 0
HIV Life Cycle R-HSA-162587 8.611214e-01 0.065 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.629796e-01 0.064 0 0
Generation of second messenger molecules R-HSA-202433 8.629796e-01 0.064 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.653133e-01 0.063 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.653133e-01 0.063 0 0
Signaling by GPCR R-HSA-372790 8.682512e-01 0.061 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.686617e-01 0.061 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.686617e-01 0.061 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.686617e-01 0.061 0 0
UCH proteinases R-HSA-5689603 8.696931e-01 0.061 0 0
Signaling by TGFB family members R-HSA-9006936 8.705553e-01 0.060 0 0
Degradation of the extracellular matrix R-HSA-1474228 8.709074e-01 0.060 0 0
Nucleotide Excision Repair R-HSA-5696398 8.711972e-01 0.060 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.725575e-01 0.059 0 0
Translation of Structural Proteins R-HSA-9694635 8.739417e-01 0.059 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.741084e-01 0.058 0 0
Translation of Structural Proteins R-HSA-9683701 8.741084e-01 0.058 0 0
Cilium Assembly R-HSA-5617833 8.749399e-01 0.058 0 0
Extracellular matrix organization R-HSA-1474244 8.753545e-01 0.058 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.780624e-01 0.056 0 0
Interleukin-10 signaling R-HSA-6783783 8.780624e-01 0.056 0 0
SLC-mediated transport of organic anions R-HSA-9955298 8.780624e-01 0.056 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.793296e-01 0.056 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 8.820584e-01 0.055 0 0
Separation of Sister Chromatids R-HSA-2467813 8.822866e-01 0.054 1 1
Selenoamino acid metabolism R-HSA-2408522 8.822866e-01 0.054 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.843346e-01 0.053 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.843346e-01 0.053 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.852035e-01 0.053 1 1
Disease R-HSA-1643685 8.873191e-01 0.052 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.891323e-01 0.051 0 0
Surfactant metabolism R-HSA-5683826 8.891323e-01 0.051 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.896898e-01 0.051 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.937312e-01 0.049 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.937312e-01 0.049 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.937312e-01 0.049 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.937312e-01 0.049 0 0
Nucleosome assembly R-HSA-774815 8.937312e-01 0.049 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.937312e-01 0.049 0 0
Inositol phosphate metabolism R-HSA-1483249 8.948001e-01 0.048 0 0
HIV Infection R-HSA-162906 8.965445e-01 0.047 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.968609e-01 0.047 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.981396e-01 0.047 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.981396e-01 0.047 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.981396e-01 0.047 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.981396e-01 0.047 0 0
Diseases of DNA repair R-HSA-9675135 8.981396e-01 0.047 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.002815e-01 0.046 0 0
tRNA processing R-HSA-72306 9.006349e-01 0.045 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 9.007915e-01 0.045 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.023655e-01 0.045 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.023655e-01 0.045 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.023655e-01 0.045 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.023655e-01 0.045 0 0
NGF-stimulated transcription R-HSA-9031628 9.064162e-01 0.043 0 0
Metal ion SLC transporters R-HSA-425410 9.064162e-01 0.043 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.064162e-01 0.043 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.064736e-01 0.043 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 9.068077e-01 0.042 1 1
Amplification of signal from the kinetochores R-HSA-141424 9.068077e-01 0.042 1 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.092028e-01 0.041 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.102992e-01 0.041 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.102992e-01 0.041 0 0
G alpha (i) signalling events R-HSA-418594 9.139181e-01 0.039 0 0
Azathioprine ADME R-HSA-9748787 9.140212e-01 0.039 0 0
Mitochondrial biogenesis R-HSA-1592230 9.144457e-01 0.039 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.175890e-01 0.037 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.210090e-01 0.036 0 0
Orc1 removal from chromatin R-HSA-68949 9.210090e-01 0.036 0 0
Neurotransmitter release cycle R-HSA-112310 9.214165e-01 0.036 0 0
Transport of small molecules R-HSA-382551 9.228664e-01 0.035 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.240770e-01 0.034 0 0
Chromosome Maintenance R-HSA-73886 9.241137e-01 0.034 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.242873e-01 0.034 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.242873e-01 0.034 0 0
Translation initiation complex formation R-HSA-72649 9.274297e-01 0.033 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.280155e-01 0.032 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.281296e-01 0.032 0 0
Paracetamol ADME R-HSA-9753281 9.304418e-01 0.031 0 0
FCGR activation R-HSA-2029481 9.315223e-01 0.031 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.333291e-01 0.030 0 0
Viral Infection Pathways R-HSA-9824446 9.353058e-01 0.029 0 0
Dectin-2 family R-HSA-5621480 9.360967e-01 0.029 0 0
Dual incision in TC-NER R-HSA-6782135 9.387496e-01 0.027 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.387496e-01 0.027 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.387496e-01 0.027 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.403904e-01 0.027 0 0
Peroxisomal protein import R-HSA-9033241 9.412926e-01 0.026 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.424308e-01 0.026 0 0
Glutathione conjugation R-HSA-156590 9.437301e-01 0.025 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.460665e-01 0.024 0 0
Mitotic Spindle Checkpoint R-HSA-69618 9.481609e-01 0.023 1 0
ABC-family proteins mediated transport R-HSA-382556 9.481609e-01 0.023 0 0
Circadian clock R-HSA-9909396 9.490274e-01 0.023 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.497742e-01 0.022 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.504527e-01 0.022 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.525104e-01 0.021 0 0
SLC transporter disorders R-HSA-5619102 9.528061e-01 0.021 0 0
Cellular response to hypoxia R-HSA-1234174 9.544828e-01 0.020 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.563733e-01 0.019 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.581854e-01 0.019 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.599224e-01 0.018 0 0
Synthesis of DNA R-HSA-69239 9.609018e-01 0.017 0 0
Keratinization R-HSA-6805567 9.617920e-01 0.017 0 0
COPII-mediated vesicle transport R-HSA-204005 9.631831e-01 0.016 0 0
ECM proteoglycans R-HSA-3000178 9.647128e-01 0.016 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.647128e-01 0.016 0 0
Metabolism of porphyrins R-HSA-189445 9.647128e-01 0.016 0 0
TCR signaling R-HSA-202403 9.648569e-01 0.016 0 0
Purine catabolism R-HSA-74259 9.661790e-01 0.015 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.661790e-01 0.015 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.702225e-01 0.013 0 0
Gastrulation R-HSA-9758941 9.720690e-01 0.012 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.726462e-01 0.012 0 0
ABC transporter disorders R-HSA-5619084 9.737832e-01 0.012 0 0
Cholesterol biosynthesis R-HSA-191273 9.737832e-01 0.012 0 0
Peptide hormone metabolism R-HSA-2980736 9.745463e-01 0.011 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.746485e-01 0.011 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.748729e-01 0.011 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.748729e-01 0.011 0 0
Protein localization R-HSA-9609507 9.754570e-01 0.011 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.779719e-01 0.010 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.796796e-01 0.009 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.799944e-01 0.009 0 0
Pyruvate metabolism R-HSA-70268 9.828548e-01 0.008 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.835679e-01 0.007 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.839293e-01 0.007 0 0
Infectious disease R-HSA-5663205 9.842896e-01 0.007 0 0
Downstream TCR signaling R-HSA-202424 9.849065e-01 0.007 0 0
Mitochondrial protein degradation R-HSA-9837999 9.877958e-01 0.005 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.879752e-01 0.005 0 0
Metabolism of proteins R-HSA-392499 9.898111e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.918311e-01 0.004 0 0
Visual phototransduction R-HSA-2187338 9.926949e-01 0.003 0 0
Antimicrobial peptides R-HSA-6803157 9.945601e-01 0.002 0 0
Metabolism of nucleotides R-HSA-15869 9.945919e-01 0.002 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.970026e-01 0.001 0 0
Regulation of Complement cascade R-HSA-977606 9.972474e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.977755e-01 0.001 0 0
Sensory perception of taste R-HSA-9717189 9.980424e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.982535e-01 0.001 0 0
Diseases of glycosylation R-HSA-3781865 9.982647e-01 0.001 0 0
Translation R-HSA-72766 9.986501e-01 0.001 0 0
Complement cascade R-HSA-166658 9.990105e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.992006e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.992660e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.995514e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.995924e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.996295e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998355e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999472e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999837e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999933e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999959e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999967e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999975e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999987e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999998e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999999e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
DNA methylation R-HSA-5334118 1.110223e-16 15.955 0 0
HCMV Early Events R-HSA-9609690 1.110223e-16 15.955 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.110223e-16 15.955 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 1 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 1 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 1 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cell-Cell communication R-HSA-1500931 1.110223e-16 15.955 0 0
Developmental Biology R-HSA-1266738 1.110223e-16 15.955 0 0
Viral Infection Pathways R-HSA-9824446 1.110223e-16 15.955 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.110223e-15 14.955 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.332268e-15 14.875 0 0
Post NMDA receptor activation events R-HSA-438064 1.998401e-15 14.699 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.440892e-15 14.353 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.440892e-15 14.353 0 0
Signal Transduction R-HSA-162582 6.217249e-15 14.206 1 0
PRC2 methylates histones and DNA R-HSA-212300 7.882583e-15 14.103 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.437695e-15 14.074 0 0
Recycling pathway of L1 R-HSA-437239 1.043610e-14 13.981 0 0
G2/M Transition R-HSA-69275 1.021405e-14 13.991 0 0
Mitotic Prophase R-HSA-68875 1.043610e-14 13.981 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.658940e-15 14.015 0 0
Gene Silencing by RNA R-HSA-211000 1.354472e-14 13.868 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.409983e-14 13.851 0 0
Cell junction organization R-HSA-446728 1.487699e-14 13.827 0 0
Influenza Infection R-HSA-168255 1.521006e-14 13.818 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.687539e-14 13.773 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.687539e-14 13.773 0 0
Cell Cycle Checkpoints R-HSA-69620 1.687539e-14 13.773 1 0
HCMV Infection R-HSA-9609646 2.309264e-14 13.637 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.386980e-14 13.622 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.497203e-14 13.456 0 0
Aggrephagy R-HSA-9646399 4.274359e-14 13.369 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.384582e-14 13.269 0 0
Mitotic Anaphase R-HSA-68882 5.828671e-14 13.234 1 0
SARS-CoV-1-host interactions R-HSA-9692914 6.383782e-14 13.195 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.572520e-14 13.182 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.716849e-14 13.173 1 0
Separation of Sister Chromatids R-HSA-2467813 1.100231e-13 12.959 1 1
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.150191e-13 12.939 0 0
Infectious disease R-HSA-5663205 1.161293e-13 12.935 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.207923e-13 12.918 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.207923e-13 12.918 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.245670e-13 12.905 0 0
Signaling by ROBO receptors R-HSA-376176 1.372236e-13 12.863 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.550982e-13 12.809 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.850742e-13 12.733 0 0
Defective pyroptosis R-HSA-9710421 1.988409e-13 12.701 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.138290e-13 12.670 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.774447e-13 12.557 0 0
G2/M Checkpoints R-HSA-69481 2.740030e-13 12.562 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.957634e-13 12.529 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.037570e-13 12.517 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.299583e-13 12.482 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.728129e-13 12.429 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.764766e-13 12.424 1 1
Inhibition of DNA recombination at telomere R-HSA-9670095 4.116707e-13 12.385 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.619638e-13 12.335 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.818368e-13 12.317 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.231371e-13 12.281 0 0
Mitotic Prometaphase R-HSA-68877 5.720979e-13 12.243 1 1
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.800116e-13 12.167 1 1
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.888934e-13 12.162 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.348566e-13 12.134 0 0
Selective autophagy R-HSA-9663891 7.149836e-13 12.146 0 0
L1CAM interactions R-HSA-373760 7.547296e-13 12.122 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.754419e-13 12.011 0 0
Packaging Of Telomere Ends R-HSA-171306 1.229017e-12 11.910 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.231348e-12 11.910 0 0
Apoptosis R-HSA-109581 1.648903e-12 11.783 0 0
Metabolism of RNA R-HSA-8953854 1.659450e-12 11.780 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.380429e-12 11.623 0 0
Ribosome-associated quality control R-HSA-9948299 2.770117e-12 11.558 0 0
Autophagy R-HSA-9612973 2.877809e-12 11.541 0 0
Meiotic recombination R-HSA-912446 2.978395e-12 11.526 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.195333e-12 11.495 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.286260e-12 11.483 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.591571e-12 11.445 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.777645e-12 11.423 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.055867e-12 11.392 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.261147e-12 11.370 0 0
Peptide chain elongation R-HSA-156902 4.324208e-12 11.364 0 0
Diseases of programmed cell death R-HSA-9645723 4.324208e-12 11.364 0 0
Macroautophagy R-HSA-1632852 4.564682e-12 11.341 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.274892e-12 11.278 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.392797e-12 11.268 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.392797e-12 11.268 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.640821e-12 11.249 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 6.542877e-12 11.184 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 6.542877e-12 11.184 0 0
Co-inhibition by PD-1 R-HSA-389948 6.171841e-12 11.210 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.861289e-12 11.164 0 0
Translation initiation complex formation R-HSA-72649 7.392309e-12 11.131 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.357981e-12 11.078 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.085909e-11 10.964 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.318190e-11 10.880 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.313616e-11 10.882 0 0
Programmed Cell Death R-HSA-5357801 1.356992e-11 10.867 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.490219e-11 10.827 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.578093e-11 10.802 0 0
Adherens junctions interactions R-HSA-418990 1.845601e-11 10.734 0 0
PKR-mediated signaling R-HSA-9833482 2.024858e-11 10.694 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.917011e-11 10.717 0 0
Cell-cell junction organization R-HSA-421270 1.941569e-11 10.712 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.099532e-11 10.678 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.170197e-11 10.664 0 0
Signaling by WNT R-HSA-195721 2.366540e-11 10.626 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.428724e-11 10.615 0 0
Cellular Senescence R-HSA-2559583 2.629164e-11 10.580 0 0
Nucleosome assembly R-HSA-774815 2.843348e-11 10.546 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.843348e-11 10.546 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.914646e-11 10.535 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.075518e-11 10.512 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.464296e-11 10.460 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.015355e-11 10.396 0 0
Meiotic synapsis R-HSA-1221632 4.083245e-11 10.389 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.243028e-11 10.372 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.576151e-11 10.339 0 0
HATs acetylate histones R-HSA-3214847 6.395484e-11 10.194 0 0
Meiosis R-HSA-1500620 6.113576e-11 10.214 0 0
HDACs deacetylate histones R-HSA-3214815 7.127299e-11 10.147 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.418310e-11 10.130 0 0
Gap junction trafficking and regulation R-HSA-157858 9.500056e-11 10.022 0 0
Cleavage of the damaged purine R-HSA-110331 1.008836e-10 9.996 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.196938e-10 9.922 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.407201e-10 9.852 0 0
Depurination R-HSA-73927 1.414776e-10 9.849 0 0
Amyloid fiber formation R-HSA-977225 1.485042e-10 9.828 0 0
Eukaryotic Translation Termination R-HSA-72764 1.552635e-10 9.809 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.627826e-10 9.788 0 0
Gap junction trafficking R-HSA-190828 1.629862e-10 9.788 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.046620e-10 9.689 0 0
Immune System R-HSA-168256 2.105207e-10 9.677 0 0
Interferon Signaling R-HSA-913531 2.629666e-10 9.580 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.633780e-10 9.579 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.865900e-10 9.543 0 0
Apoptotic execution phase R-HSA-75153 2.944510e-10 9.531 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.052832e-10 9.515 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.089774e-10 9.510 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.197851e-10 9.495 0 0
EPH-Ephrin signaling R-HSA-2682334 3.768502e-10 9.424 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.306128e-10 9.366 0 0
Selenocysteine synthesis R-HSA-2408557 4.715390e-10 9.326 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.633842e-10 9.249 0 0
Viral mRNA Translation R-HSA-192823 6.718034e-10 9.173 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.813080e-10 9.167 0 0
Depyrimidination R-HSA-73928 6.813080e-10 9.167 0 0
Disease R-HSA-1643685 1.307739e-09 8.883 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.336046e-09 8.874 0 0
DNA Double Strand Break Response R-HSA-5693606 1.373058e-09 8.862 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.647363e-09 8.783 0 0
ESR-mediated signaling R-HSA-8939211 1.952038e-09 8.710 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.044432e-09 8.689 0 0
Ub-specific processing proteases R-HSA-5689880 2.355023e-09 8.628 0 0
RNA Polymerase I Transcription R-HSA-73864 2.472248e-09 8.607 0 0
Gap junction assembly R-HSA-190861 2.592583e-09 8.586 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.636185e-09 8.579 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.002416e-09 8.523 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.150827e-09 8.382 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.445025e-09 8.352 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.445025e-09 8.352 0 0
Regulation of CDH1 Function R-HSA-9764561 5.112012e-09 8.291 0 0
MAPK family signaling cascades R-HSA-5683057 6.406369e-09 8.193 0 0
Host Interactions of HIV factors R-HSA-162909 6.729811e-09 8.172 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.328979e-09 8.135 0 0
DNA Replication R-HSA-69306 9.083279e-09 8.042 0 0
Signaling by ERBB2 R-HSA-1227986 1.009583e-08 7.996 0 0
Adaptive Immune System R-HSA-1280218 1.092067e-08 7.962 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.343935e-08 7.872 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.560287e-08 7.807 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.705268e-08 7.768 0 0
Cellular response to heat stress R-HSA-3371556 1.817485e-08 7.741 0 0
Chromosome Maintenance R-HSA-73886 1.817485e-08 7.741 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.151900e-08 7.667 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.273064e-08 7.643 0 0
Translation R-HSA-72766 2.382472e-08 7.623 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.707670e-08 7.567 0 0
Telomere Maintenance R-HSA-157579 2.537609e-08 7.596 0 0
Signaling by NOTCH R-HSA-157118 2.655121e-08 7.576 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.907710e-08 7.536 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.167242e-08 7.499 0 0
Selenoamino acid metabolism R-HSA-2408522 3.401798e-08 7.468 0 0
Glycolysis R-HSA-70171 4.062152e-08 7.391 0 0
Interleukin-12 signaling R-HSA-9020591 4.590195e-08 7.338 0 0
HCMV Late Events R-HSA-9610379 5.374323e-08 7.270 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.553017e-08 7.255 0 0
Cellular response to starvation R-HSA-9711097 6.030878e-08 7.220 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.345210e-08 7.198 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.595039e-08 7.119 0 0
Interleukin-12 family signaling R-HSA-447115 7.595039e-08 7.119 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 8.659383e-08 7.063 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.161518e-08 7.038 0 0
Deubiquitination R-HSA-5688426 1.027669e-07 6.988 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.141296e-07 6.943 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.155065e-07 6.937 0 0
Chromatin modifying enzymes R-HSA-3247509 1.400648e-07 6.854 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.404291e-07 6.853 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.404291e-07 6.853 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.404291e-07 6.853 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.449089e-07 6.839 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.703668e-07 6.769 0 0
Hedgehog 'off' state R-HSA-5610787 1.746390e-07 6.758 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.747655e-07 6.758 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.819642e-07 6.740 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.939887e-07 6.712 0 0
Protein folding R-HSA-391251 1.961424e-07 6.707 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.458221e-07 6.609 0 0
Signaling by Interleukins R-HSA-449147 2.611542e-07 6.583 0 0
Reproduction R-HSA-1474165 2.950035e-07 6.530 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.990402e-07 6.524 0 0
Kinesins R-HSA-983189 3.114612e-07 6.507 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.526083e-07 6.453 0 0
RMTs methylate histone arginines R-HSA-3214858 3.526083e-07 6.453 0 0
Long-term potentiation R-HSA-9620244 4.547657e-07 6.342 0 0
Chromatin organization R-HSA-4839726 5.064844e-07 6.295 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.138883e-07 6.289 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.410746e-07 6.267 0 0
Signaling by RAS mutants R-HSA-6802949 5.484461e-07 6.261 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.484461e-07 6.261 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.484461e-07 6.261 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.484461e-07 6.261 0 0
Glucose metabolism R-HSA-70326 6.440715e-07 6.191 0 0
SARS-CoV Infections R-HSA-9679506 6.825245e-07 6.166 0 0
Homology Directed Repair R-HSA-5693538 7.285737e-07 6.138 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.305426e-07 6.081 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.583409e-07 6.018 0 0
rRNA processing R-HSA-72312 9.897569e-07 6.004 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.293173e-06 5.888 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.307759e-06 5.883 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.341898e-06 5.872 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.452975e-06 5.838 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.511587e-06 5.821 0 0
Cilium Assembly R-HSA-5617833 1.721334e-06 5.764 0 0
HIV Infection R-HSA-162906 1.843330e-06 5.734 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.849090e-06 5.733 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.857848e-06 5.731 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.902957e-06 5.721 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.124429e-06 5.673 0 0
Base Excision Repair R-HSA-73884 2.242926e-06 5.649 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.489476e-06 5.604 0 0
Transmission across Chemical Synapses R-HSA-112315 2.489476e-06 5.604 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.780777e-06 5.556 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.693788e-06 5.433 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.063301e-06 5.391 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.349944e-06 5.362 0 0
Metalloprotease DUBs R-HSA-5689901 4.561533e-06 5.341 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.917063e-06 5.308 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.917063e-06 5.308 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.917063e-06 5.308 0 0
Signaling by VEGF R-HSA-194138 6.390679e-06 5.194 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.418264e-06 5.193 0 0
Metabolism of proteins R-HSA-392499 8.374553e-06 5.077 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.692096e-06 5.061 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.844174e-06 5.053 0 0
Signaling by Hedgehog R-HSA-5358351 9.075670e-06 5.042 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 9.985451e-06 5.001 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 9.985451e-06 5.001 0 0
Hemostasis R-HSA-109582 1.030162e-05 4.987 0 0
Signaling by PTK6 R-HSA-8848021 1.213580e-05 4.916 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.213580e-05 4.916 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.215150e-05 4.915 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.230437e-05 4.910 0 0
Membrane Trafficking R-HSA-199991 1.326481e-05 4.877 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.465054e-05 4.834 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.509881e-05 4.821 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.572893e-05 4.803 0 0
Protein ubiquitination R-HSA-8852135 1.643114e-05 4.784 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.902605e-05 4.721 0 0
UCH proteinases R-HSA-5689603 1.883186e-05 4.725 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.127652e-05 4.672 0 0
Intraflagellar transport R-HSA-5620924 2.263022e-05 4.645 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.571042e-05 4.590 0 0
Signaling by ALK in cancer R-HSA-9700206 2.571042e-05 4.590 0 0
Regulation of signaling by CBL R-HSA-912631 2.589813e-05 4.587 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.703163e-05 4.568 0 0
MAP2K and MAPK activation R-HSA-5674135 3.250321e-05 4.488 0 0
Nephrin family interactions R-HSA-373753 3.444366e-05 4.463 0 0
Nuclear import of Rev protein R-HSA-180746 3.717834e-05 4.430 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.717834e-05 4.430 0 0
HSF1-dependent transactivation R-HSA-3371571 3.723909e-05 4.429 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.089503e-05 4.388 0 0
Gene expression (Transcription) R-HSA-74160 4.172736e-05 4.380 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.391534e-05 4.357 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.435647e-05 4.353 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.579050e-05 4.339 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.893250e-05 4.310 0 0
MHC class II antigen presentation R-HSA-2132295 4.903489e-05 4.309 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.182976e-05 4.285 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.182976e-05 4.285 0 0
Semaphorin interactions R-HSA-373755 5.182976e-05 4.285 0 0
DNA Repair R-HSA-73894 5.195257e-05 4.284 0 0
HIV Life Cycle R-HSA-162587 5.448120e-05 4.264 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.501934e-05 4.259 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.868839e-05 4.231 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.868839e-05 4.231 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.605686e-05 4.180 1 1
Amplification of signal from the kinetochores R-HSA-141424 6.605686e-05 4.180 1 0
PECAM1 interactions R-HSA-210990 6.862262e-05 4.164 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.486181e-05 4.126 0 0
mTORC1-mediated signalling R-HSA-166208 7.532663e-05 4.123 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.532663e-05 4.123 0 0
Signaling by KIT in disease R-HSA-9669938 7.532663e-05 4.123 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.805473e-05 4.108 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.082731e-05 4.092 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 8.082731e-05 4.092 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.236986e-05 4.084 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.346905e-05 4.029 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.391827e-05 4.027 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 9.517784e-05 4.021 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.357506e-04 3.867 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.357506e-04 3.867 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.131516e-04 3.946 0 0
Signaling by Hippo R-HSA-2028269 1.095184e-04 3.961 0 0
Degradation of CDH1 R-HSA-9766229 1.221904e-04 3.913 0 0
Regulation of PTEN localization R-HSA-8948747 1.370536e-04 3.863 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.375058e-04 3.862 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.418185e-04 3.848 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.635283e-04 3.786 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.873266e-04 3.727 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.873266e-04 3.727 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.950916e-04 3.710 0 0
RAF activation R-HSA-5673000 1.958887e-04 3.708 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.122795e-04 3.673 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.175346e-04 3.662 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.189659e-04 3.660 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.334047e-04 3.632 0 0
Centrosome maturation R-HSA-380287 2.361508e-04 3.627 0 0
Neuronal System R-HSA-112316 2.482268e-04 3.605 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.641358e-04 3.578 0 0
Regulation of KIT signaling R-HSA-1433559 2.641358e-04 3.578 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.923850e-04 3.534 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.996752e-04 3.523 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.996752e-04 3.523 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.154462e-04 3.501 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.264304e-04 3.486 0 0
PCP/CE pathway R-HSA-4086400 3.296221e-04 3.482 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.363766e-04 3.473 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.379985e-04 3.471 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.510566e-04 3.455 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.510566e-04 3.455 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.612546e-04 3.442 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.747521e-04 3.426 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.747521e-04 3.426 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.747521e-04 3.426 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.747521e-04 3.426 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.843497e-04 3.415 1 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.943151e-04 3.404 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.044184e-04 3.393 0 0
Activation of BH3-only proteins R-HSA-114452 4.044184e-04 3.393 0 0
Gluconeogenesis R-HSA-70263 4.471407e-04 3.350 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.481525e-04 3.349 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.481525e-04 3.349 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.610195e-04 3.336 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.641706e-04 3.333 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.727819e-04 3.325 0 0
snRNP Assembly R-HSA-191859 4.738781e-04 3.324 0 0
Metabolism of non-coding RNA R-HSA-194441 4.738781e-04 3.324 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.832429e-04 3.316 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.832429e-04 3.316 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.832429e-04 3.316 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.217291e-04 3.283 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.217291e-04 3.283 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.217291e-04 3.283 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.739543e-04 3.241 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.885245e-04 3.230 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.885245e-04 3.230 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.909449e-04 3.228 0 0
FLT3 Signaling R-HSA-9607240 6.049287e-04 3.218 0 0
Platelet degranulation R-HSA-114608 6.303996e-04 3.200 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.307679e-04 3.200 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 6.307679e-04 3.200 0 0
Maturation of protein E R-HSA-9683683 6.479219e-04 3.188 0 0
Maturation of protein E R-HSA-9694493 6.479219e-04 3.188 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.763882e-04 3.170 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.782413e-04 3.169 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.782413e-04 3.169 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.937583e-04 3.159 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.937583e-04 3.159 0 0
Signaling by NOTCH4 R-HSA-9013694 7.271713e-04 3.138 0 0
Ephrin signaling R-HSA-3928664 9.419767e-04 3.026 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.005199e-03 2.998 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.005199e-03 2.998 0 0
Nef and signal transduction R-HSA-164944 9.997034e-04 3.000 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.971176e-04 3.098 0 0
Mitophagy R-HSA-5205647 9.321807e-04 3.030 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.743188e-04 3.111 0 0
Signaling by SCF-KIT R-HSA-1433557 9.217862e-04 3.035 0 0
TCR signaling R-HSA-202403 9.889030e-04 3.005 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.971176e-04 3.098 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.832667e-04 3.007 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.061403e-04 3.094 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.039521e-04 3.095 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.084981e-03 2.965 0 0
Regulation of Apoptosis R-HSA-169911 1.084981e-03 2.965 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.137948e-03 2.944 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.137948e-03 2.944 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.137948e-03 2.944 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.137948e-03 2.944 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.199523e-03 2.921 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.199523e-03 2.921 0 0
Signaling by EGFR R-HSA-177929 1.216333e-03 2.915 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.257146e-03 2.901 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.257146e-03 2.901 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.394278e-03 2.856 0 0
Degradation of AXIN R-HSA-4641257 1.450380e-03 2.839 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.450380e-03 2.839 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.450380e-03 2.839 0 0
Degradation of DVL R-HSA-4641258 1.450380e-03 2.839 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.450380e-03 2.839 0 0
mRNA Splicing R-HSA-72172 1.461811e-03 2.835 0 0
Generic Transcription Pathway R-HSA-212436 1.464192e-03 2.834 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.491883e-03 2.826 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.587877e-03 2.799 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.666459e-03 2.778 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.667431e-03 2.778 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.667431e-03 2.778 0 0
Late endosomal microautophagy R-HSA-9615710 1.667431e-03 2.778 0 0
PTEN Regulation R-HSA-6807070 1.704469e-03 2.768 0 0
Vesicle-mediated transport R-HSA-5653656 1.734571e-03 2.761 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.751630e-03 2.757 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.769592e-03 2.752 0 0
Cellular response to chemical stress R-HSA-9711123 1.841077e-03 2.735 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.897854e-03 2.722 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.907232e-03 2.720 0 0
Post-translational protein modification R-HSA-597592 1.945826e-03 2.711 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.950625e-03 2.710 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.070288e-03 2.684 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.070288e-03 2.684 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.070288e-03 2.684 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.095135e-03 2.679 0 0
MAP kinase activation R-HSA-450294 2.095135e-03 2.679 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.095135e-03 2.679 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.174615e-03 2.663 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.269696e-03 2.644 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.269696e-03 2.644 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.304266e-03 2.637 0 0
Signaling by ERBB4 R-HSA-1236394 2.327286e-03 2.633 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.392706e-03 2.621 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.392706e-03 2.621 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.392706e-03 2.621 0 0
DCC mediated attractive signaling R-HSA-418885 2.392706e-03 2.621 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.392706e-03 2.621 0 0
p75NTR signals via NF-kB R-HSA-193639 2.392706e-03 2.621 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.457672e-03 2.609 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.457672e-03 2.609 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.470588e-03 2.607 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.470588e-03 2.607 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.470588e-03 2.607 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.514914e-03 2.599 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.565408e-03 2.591 0 0
RNA Polymerase II Transcription R-HSA-73857 2.628597e-03 2.580 0 0
Orc1 removal from chromatin R-HSA-68949 2.743525e-03 2.562 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.797192e-03 2.553 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.797192e-03 2.553 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.797192e-03 2.553 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.797192e-03 2.553 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.797192e-03 2.553 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.827162e-03 2.549 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.899191e-03 2.538 0 0
Regulation of BACH1 activity R-HSA-9708530 2.975184e-03 2.526 0 0
Negative regulation of FLT3 R-HSA-9706369 2.975184e-03 2.526 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.003102e-03 2.522 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.027261e-03 2.519 0 0
Cellular response to hypoxia R-HSA-1234174 3.116671e-03 2.506 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.146173e-03 2.502 0 0
MTOR signalling R-HSA-165159 3.156525e-03 2.501 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.471847e-03 2.459 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.471847e-03 2.459 0 0
Deadenylation of mRNA R-HSA-429947 3.515483e-03 2.454 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.550741e-03 2.450 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.748892e-03 2.426 0 0
Josephin domain DUBs R-HSA-5689877 3.748892e-03 2.426 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.748892e-03 2.426 0 0
Pexophagy R-HSA-9664873 3.748892e-03 2.426 0 0
Dual Incision in GG-NER R-HSA-5696400 3.964474e-03 2.402 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.964474e-03 2.402 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.964474e-03 2.402 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.982036e-03 2.400 0 0
Netrin-1 signaling R-HSA-373752 3.982036e-03 2.400 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.982036e-03 2.400 0 0
G1 Phase R-HSA-69236 3.982036e-03 2.400 0 0
Cyclin D associated events in G1 R-HSA-69231 3.982036e-03 2.400 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.114296e-03 2.386 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.159526e-03 2.381 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.452656e-03 2.351 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.508338e-03 2.346 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.833476e-03 2.316 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.347610e-03 2.197 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.347610e-03 2.197 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.964880e-03 2.304 0 0
Neutrophil degranulation R-HSA-6798695 5.666200e-03 2.247 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.331059e-03 2.199 0 0
Translesion Synthesis by POLH R-HSA-110320 6.347610e-03 2.197 0 0
DNA Damage Bypass R-HSA-73893 6.774470e-03 2.169 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.952958e-03 2.158 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.363716e-03 2.196 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.331658e-03 2.273 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.912471e-03 2.309 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.533485e-03 2.257 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.353435e-03 2.271 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.353435e-03 2.271 0 0
Co-stimulation by CD28 R-HSA-389356 6.123433e-03 2.213 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.743979e-03 2.171 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.743979e-03 2.171 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.621830e-03 2.179 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.283761e-03 2.138 0 0
Interleukin-17 signaling R-HSA-448424 4.912471e-03 2.309 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.912471e-03 2.309 0 0
tRNA processing in the nucleus R-HSA-6784531 7.283761e-03 2.138 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.774470e-03 2.169 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.774470e-03 2.169 0 0
Stabilization of p53 R-HSA-69541 7.261388e-03 2.139 0 0
NF-kB is activated and signals survival R-HSA-209560 6.169880e-03 2.210 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.167726e-03 2.287 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.598582e-03 2.252 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.492167e-03 2.125 0 0
Glycogen synthesis R-HSA-3322077 7.492167e-03 2.125 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.697071e-03 2.114 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.697071e-03 2.114 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.697071e-03 2.114 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.697071e-03 2.114 0 0
Attenuation phase R-HSA-3371568 8.110531e-03 2.091 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.231973e-03 2.084 0 0
G1/S Transition R-HSA-69206 8.536039e-03 2.069 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.773044e-03 2.057 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.773044e-03 2.057 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.773044e-03 2.057 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.905421e-03 2.050 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.030630e-03 2.044 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.030630e-03 2.044 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.043231e-03 2.044 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.043231e-03 2.044 0 0
Downstream TCR signaling R-HSA-202424 9.092260e-03 2.041 0 0
Manipulation of host energy metabolism R-HSA-9636667 9.299984e-03 2.032 0 0
EGFR downregulation R-HSA-182971 9.395612e-03 2.027 0 0
Trafficking of AMPA receptors R-HSA-399719 9.395612e-03 2.027 0 0
Budding and maturation of HIV virion R-HSA-162588 9.395612e-03 2.027 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.453747e-03 2.024 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 9.560267e-03 2.020 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.912694e-03 2.004 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.912694e-03 2.004 0 0
Smooth Muscle Contraction R-HSA-445355 9.912694e-03 2.004 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.019768e-02 1.991 0 0
Assembly Of The HIV Virion R-HSA-175474 1.019768e-02 1.991 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.060261e-02 1.975 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.084275e-02 1.965 0 0
Signaling by FGFR2 R-HSA-5654738 1.085712e-02 1.964 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.132970e-02 1.946 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.145223e-02 1.941 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.145223e-02 1.941 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.145223e-02 1.941 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.183579e-02 1.927 0 0
Signaling by NOTCH3 R-HSA-9012852 1.183579e-02 1.927 0 0
Nucleotide Excision Repair R-HSA-5696398 1.187386e-02 1.925 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.191556e-02 1.924 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.199987e-02 1.921 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.224930e-02 1.912 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.224930e-02 1.912 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.266555e-02 1.897 0 0
Disinhibition of SNARE formation R-HSA-114516 1.266555e-02 1.897 0 0
SOS-mediated signalling R-HSA-112412 1.266555e-02 1.897 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.266555e-02 1.897 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.289417e-02 1.890 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.289417e-02 1.890 0 0
TNF signaling R-HSA-75893 1.289417e-02 1.890 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.289417e-02 1.890 0 0
Circadian clock R-HSA-9909396 1.325764e-02 1.878 0 0
Translesion synthesis by REV1 R-HSA-110312 1.370363e-02 1.863 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.370363e-02 1.863 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.436392e-02 1.843 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.480899e-02 1.829 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.480899e-02 1.829 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.487712e-02 1.827 0 0
Hedgehog 'on' state R-HSA-5632684 1.497891e-02 1.825 0 0
Dual incision in TC-NER R-HSA-6782135 1.521627e-02 1.818 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.533833e-02 1.814 0 0
Neurodegenerative Diseases R-HSA-8863678 1.540371e-02 1.812 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.540371e-02 1.812 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.540371e-02 1.812 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.602426e-02 1.795 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.602426e-02 1.795 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.602426e-02 1.795 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.602426e-02 1.795 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.602426e-02 1.795 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.602426e-02 1.795 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.602426e-02 1.795 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.602426e-02 1.795 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.602426e-02 1.795 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.602426e-02 1.795 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.602426e-02 1.795 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.602426e-02 1.795 0 0
Translesion synthesis by POLI R-HSA-5656121 1.621780e-02 1.790 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.621780e-02 1.790 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.621780e-02 1.790 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.622230e-02 1.790 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.622230e-02 1.790 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.622230e-02 1.790 0 0
Type I hemidesmosome assembly R-HSA-446107 1.628256e-02 1.788 0 0
Formation of annular gap junctions R-HSA-196025 1.628256e-02 1.788 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.628256e-02 1.788 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.630217e-02 1.788 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.653426e-02 1.782 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.729263e-02 1.762 0 0
Interleukin-7 signaling R-HSA-1266695 1.747109e-02 1.758 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.772856e-02 1.751 0 0
HSF1 activation R-HSA-3371511 1.831441e-02 1.737 0 0
FLT3 signaling in disease R-HSA-9682385 1.831441e-02 1.737 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.900333e-02 1.721 0 0
Translesion synthesis by POLK R-HSA-5655862 1.900333e-02 1.721 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.900333e-02 1.721 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.900333e-02 1.721 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.900333e-02 1.721 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.933062e-02 1.714 0 0
Suppression of phagosomal maturation R-HSA-9637687 1.971414e-02 1.705 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.022139e-02 1.694 0 0
Gap junction degradation R-HSA-190873 2.041964e-02 1.690 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.041964e-02 1.690 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.041964e-02 1.690 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.041964e-02 1.690 0 0
ER-Phagosome pathway R-HSA-1236974 2.112252e-02 1.675 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.206754e-02 1.656 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.206754e-02 1.656 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.206754e-02 1.656 0 0
Glycogen storage diseases R-HSA-3229121 2.206754e-02 1.656 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.213798e-02 1.655 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.213798e-02 1.655 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.427224e-02 1.615 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.436327e-02 1.613 0 0
RAS processing R-HSA-9648002 2.443021e-02 1.612 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.474728e-02 1.606 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.494834e-02 1.603 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.508037e-02 1.601 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.508037e-02 1.601 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.541647e-02 1.595 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.541647e-02 1.595 0 0
Glycogen metabolism R-HSA-8982491 2.673870e-02 1.573 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.675084e-02 1.573 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.705665e-02 1.568 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.754622e-02 1.560 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.754622e-02 1.560 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.905496e-02 1.537 0 0
S Phase R-HSA-69242 3.105023e-02 1.508 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.150291e-02 1.502 0 0
Regulated Necrosis R-HSA-5218859 3.150291e-02 1.502 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.167408e-02 1.499 0 0
Muscle contraction R-HSA-397014 3.270361e-02 1.485 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.298659e-02 1.482 0 0
Signal transduction by L1 R-HSA-445144 3.298659e-02 1.482 0 0
Negative regulation of MET activity R-HSA-6807004 3.298659e-02 1.482 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.330516e-02 1.477 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.372737e-02 1.472 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.388160e-02 1.470 0 0
MTF1 activates gene expression R-HSA-5660489 3.388160e-02 1.470 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.451555e-02 1.462 0 0
Ca-dependent events R-HSA-111996 3.451555e-02 1.462 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 4.657495e-02 1.332 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.471395e-02 1.350 0 0
IRS activation R-HSA-74713 4.471395e-02 1.350 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.663290e-02 1.247 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.951401e-02 1.158 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.951401e-02 1.158 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.217962e-02 1.375 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.217962e-02 1.375 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.889340e-02 1.311 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.609484e-02 1.251 0 0
Erythropoietin activates RAS R-HSA-9027284 6.376898e-02 1.195 0 0
p38MAPK events R-HSA-171007 6.376898e-02 1.195 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.173783e-02 1.379 0 0
FGFR2 alternative splicing R-HSA-6803529 4.655890e-02 1.332 0 0
Striated Muscle Contraction R-HSA-390522 4.449791e-02 1.352 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.824904e-02 1.317 0 0
Integrin signaling R-HSA-354192 4.070509e-02 1.390 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.361934e-02 1.360 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.471395e-02 1.350 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.596636e-02 1.444 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.789986e-02 1.237 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.721379e-02 1.429 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.663290e-02 1.247 0 0
Signalling to ERKs R-HSA-187687 5.269760e-02 1.278 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.279080e-02 1.202 0 0
Parasite infection R-HSA-9664407 4.142115e-02 1.383 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.142115e-02 1.383 0 0
Leishmania phagocytosis R-HSA-9664417 4.142115e-02 1.383 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.471395e-02 1.350 0 0
CREB phosphorylation R-HSA-199920 6.951401e-02 1.158 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.489106e-02 1.188 0 0
Protein methylation R-HSA-8876725 6.376898e-02 1.195 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.891251e-02 1.230 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.790871e-02 1.168 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.235692e-02 1.373 0 0
Basigin interactions R-HSA-210991 3.721379e-02 1.429 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.795991e-02 1.168 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.878175e-02 1.163 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.376898e-02 1.195 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.545590e-02 1.184 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.173783e-02 1.379 0 0
RSV-host interactions R-HSA-9833110 5.481172e-02 1.261 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.906870e-02 1.408 0 0
Innate Immune System R-HSA-168249 3.599200e-02 1.444 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.906870e-02 1.408 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.906870e-02 1.408 0 0
G0 and Early G1 R-HSA-1538133 3.711549e-02 1.430 0 0
Signaling by NTRKs R-HSA-166520 5.891251e-02 1.230 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.849516e-02 1.314 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.988940e-02 1.223 0 0
Interleukin-1 signaling R-HSA-9020702 4.537726e-02 1.343 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.042418e-02 1.393 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.641161e-02 1.333 0 0
Syndecan interactions R-HSA-3000170 5.167614e-02 1.287 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.070509e-02 1.390 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 3.590581e-02 1.445 0 0
Signaling by MET R-HSA-6806834 6.321098e-02 1.199 0 0
NrCAM interactions R-HSA-447038 4.471395e-02 1.350 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.663290e-02 1.247 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.167614e-02 1.287 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.878175e-02 1.163 0 0
Sensory processing of sound R-HSA-9659379 6.001211e-02 1.222 0 0
Calmodulin induced events R-HSA-111933 5.710549e-02 1.243 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.070509e-02 1.390 0 0
DAG and IP3 signaling R-HSA-1489509 4.361934e-02 1.360 0 0
CaM pathway R-HSA-111997 5.710549e-02 1.243 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.663290e-02 1.247 0 0
Signal regulatory protein family interactions R-HSA-391160 5.609484e-02 1.251 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.878579e-02 1.231 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.653640e-02 1.177 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.695752e-02 1.328 0 0
Growth hormone receptor signaling R-HSA-982772 5.167614e-02 1.287 0 0
Signaling by FGFR4 R-HSA-5654743 3.739996e-02 1.427 0 0
Signaling by FGFR3 R-HSA-5654741 4.361934e-02 1.360 0 0
Signaling by FGFR R-HSA-190236 3.906870e-02 1.408 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.721379e-02 1.429 0 0
RET signaling R-HSA-8853659 5.710549e-02 1.243 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.590581e-02 1.445 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.967069e-02 1.402 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.824190e-02 1.235 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.350261e-02 1.272 0 0
mRNA 3'-end processing R-HSA-72187 7.024564e-02 1.153 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.024564e-02 1.153 0 0
Signaling by ALK R-HSA-201556 7.155766e-02 1.145 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.155766e-02 1.145 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.155766e-02 1.145 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.189912e-02 1.143 0 0
Death Receptor Signaling R-HSA-73887 7.299586e-02 1.137 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.505607e-02 1.125 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.505607e-02 1.125 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.505607e-02 1.125 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.505607e-02 1.125 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.505607e-02 1.125 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.505607e-02 1.125 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.505607e-02 1.125 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.678092e-02 1.115 0 0
Inositol phosphate metabolism R-HSA-1483249 7.734088e-02 1.112 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.031972e-02 1.095 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.046710e-02 1.094 0 0
HIV elongation arrest and recovery R-HSA-167287 8.160850e-02 1.088 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.160850e-02 1.088 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.220423e-02 1.085 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.220423e-02 1.085 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.324207e-02 1.080 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 8.324207e-02 1.080 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 8.324207e-02 1.080 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.324207e-02 1.080 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 8.324207e-02 1.080 0 0
G alpha (z) signalling events R-HSA-418597 8.399255e-02 1.076 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.531509e-02 1.069 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.843308e-02 1.053 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.853550e-02 1.053 0 0
Signaling by FGFR1 R-HSA-5654736 8.888290e-02 1.051 0 0
Regulation of TP53 Activity R-HSA-5633007 8.910145e-02 1.050 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.945357e-02 1.048 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.945357e-02 1.048 0 0
Developmental Cell Lineages R-HSA-9734767 8.959207e-02 1.048 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 9.098336e-02 1.041 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 9.098336e-02 1.041 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 9.098336e-02 1.041 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 9.098336e-02 1.041 0 0
TICAM1 deficiency - HSE R-HSA-5602566 9.098336e-02 1.041 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 9.098336e-02 1.041 0 0
Hereditary fructose intolerance R-HSA-5657560 9.098336e-02 1.041 0 0
Activation and oligomerization of BAK protein R-HSA-111452 9.098336e-02 1.041 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 9.098336e-02 1.041 0 0
Inhibition of PKR R-HSA-169131 9.098336e-02 1.041 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.182937e-02 1.037 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.182937e-02 1.037 0 0
Pyruvate metabolism R-HSA-70268 9.257239e-02 1.034 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.392528e-02 1.027 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.638329e-02 1.016 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 9.771047e-02 1.010 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 9.771047e-02 1.010 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 9.771047e-02 1.010 0 0
Interleukin-9 signaling R-HSA-8985947 9.771047e-02 1.010 0 0
GAB1 signalosome R-HSA-180292 9.883820e-02 1.005 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.883820e-02 1.005 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.883820e-02 1.005 0 0
Polo-like kinase mediated events R-HSA-156711 9.883820e-02 1.005 0 0
Downstream signal transduction R-HSA-186763 1.028716e-01 0.988 0 0
Peroxisomal protein import R-HSA-9033241 1.044598e-01 0.981 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.044598e-01 0.981 0 0
Proteasome assembly R-HSA-9907900 1.058459e-01 0.975 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.086787e-01 0.964 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.086787e-01 0.964 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.099482e-01 0.959 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.099482e-01 0.959 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.099482e-01 0.959 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.099482e-01 0.959 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.099482e-01 0.959 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.099482e-01 0.959 0 0
RAB geranylgeranylation R-HSA-8873719 1.099482e-01 0.959 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.122273e-01 0.950 0 0
ARMS-mediated activation R-HSA-170984 1.128207e-01 0.948 0 0
Lipophagy R-HSA-9613354 1.128207e-01 0.948 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 1.128207e-01 0.948 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 1.128207e-01 0.948 0 0
ALK mutants bind TKIs R-HSA-9700645 1.128207e-01 0.948 0 0
Calcineurin activates NFAT R-HSA-2025928 1.128207e-01 0.948 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 1.128207e-01 0.948 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.155813e-01 0.937 0 0
PLC beta mediated events R-HSA-112043 1.155813e-01 0.937 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.161601e-01 0.935 0 0
Synthesis of DNA R-HSA-69239 1.203340e-01 0.920 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.205278e-01 0.919 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.205278e-01 0.919 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.209696e-01 0.917 0 0
ABC transporter disorders R-HSA-5619084 1.209696e-01 0.917 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.255280e-01 0.901 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.263870e-01 0.898 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.263870e-01 0.898 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.272716e-01 0.895 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.284817e-01 0.891 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.284817e-01 0.891 0 0
Regulation of CDH11 function R-HSA-9762292 1.284817e-01 0.891 0 0
PI3K/AKT activation R-HSA-198203 1.284817e-01 0.891 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.284817e-01 0.891 0 0
Signal attenuation R-HSA-74749 1.284817e-01 0.891 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.284817e-01 0.891 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.284817e-01 0.891 0 0
Signaling by Leptin R-HSA-2586552 1.284817e-01 0.891 0 0
Formation of the cornified envelope R-HSA-6809371 1.288081e-01 0.890 0 0
Signalling to RAS R-HSA-167044 1.291679e-01 0.889 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 1.291679e-01 0.889 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.291679e-01 0.889 0 0
Ion transport by P-type ATPases R-HSA-936837 1.333236e-01 0.875 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.333259e-01 0.875 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.333259e-01 0.875 0 0
XAV939 stabilizes AXIN R-HSA-5545619 1.333259e-01 0.875 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.333259e-01 0.875 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.333259e-01 0.875 0 0
TRAF3 deficiency - HSE R-HSA-5602571 1.333259e-01 0.875 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 1.333259e-01 0.875 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.333259e-01 0.875 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.333259e-01 0.875 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.346868e-01 0.871 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.346868e-01 0.871 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.346868e-01 0.871 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.346868e-01 0.871 0 0
Signaling by NOTCH2 R-HSA-1980145 1.346868e-01 0.871 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.387470e-01 0.858 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.399299e-01 0.854 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.399299e-01 0.854 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.399299e-01 0.854 0 0
Oncogene Induced Senescence R-HSA-2559585 1.432017e-01 0.844 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.446096e-01 0.840 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.446096e-01 0.840 0 0
Bicarbonate transporters R-HSA-425381 1.446096e-01 0.840 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.446096e-01 0.840 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 1.484500e-01 0.828 0 0
Signaling by TGFB family members R-HSA-9006936 1.492421e-01 0.826 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.509809e-01 0.821 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.509809e-01 0.821 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.519224e-01 0.818 0 0
RNA Polymerase III Transcription R-HSA-74158 1.519224e-01 0.818 0 0
G-protein mediated events R-HSA-112040 1.522716e-01 0.817 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.596334e-01 0.797 0 0
FOXO-mediated transcription R-HSA-9614085 1.596334e-01 0.797 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.611271e-01 0.793 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.611271e-01 0.793 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.611271e-01 0.793 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.611271e-01 0.793 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.622987e-01 0.790 0 0
Interferon alpha/beta signaling R-HSA-909733 1.680842e-01 0.774 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 1.699408e-01 0.770 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.736985e-01 0.760 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.736985e-01 0.760 0 0
Potassium transport channels R-HSA-1296067 1.736985e-01 0.760 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.736985e-01 0.760 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.736985e-01 0.760 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 1.736985e-01 0.760 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.736985e-01 0.760 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.736985e-01 0.760 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.736985e-01 0.760 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 1.736985e-01 0.760 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 1.738610e-01 0.760 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.779631e-01 0.750 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.779631e-01 0.750 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.779631e-01 0.750 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.779631e-01 0.750 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.779631e-01 0.750 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.779631e-01 0.750 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.779631e-01 0.750 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.779631e-01 0.750 0 0
SLC transporter disorders R-HSA-5619102 1.790092e-01 0.747 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.792183e-01 0.747 0 0
Pentose phosphate pathway R-HSA-71336 1.792183e-01 0.747 0 0
HDMs demethylate histones R-HSA-3214842 1.856461e-01 0.731 0 0
Tight junction interactions R-HSA-420029 1.856461e-01 0.731 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 1.856461e-01 0.731 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 1.856461e-01 0.731 0 0
Opioid Signalling R-HSA-111885 1.879599e-01 0.726 0 0
HIV Transcription Elongation R-HSA-167169 1.886610e-01 0.724 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.886610e-01 0.724 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.886610e-01 0.724 0 0
Generation of second messenger molecules R-HSA-202433 1.886610e-01 0.724 0 0
Ion homeostasis R-HSA-5578775 1.932857e-01 0.714 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 1.934279e-01 0.713 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.950521e-01 0.710 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.950521e-01 0.710 0 0
Interleukin-6 signaling R-HSA-1059683 1.950521e-01 0.710 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.950521e-01 0.710 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.950521e-01 0.710 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.950521e-01 0.710 0 0
Myogenesis R-HSA-525793 1.976323e-01 0.704 0 0
Protein localization R-HSA-9609507 1.988262e-01 0.702 0 0
Ion channel transport R-HSA-983712 1.996705e-01 0.700 0 0
Integration of energy metabolism R-HSA-163685 1.999614e-01 0.699 0 0
Translation of Structural Proteins R-HSA-9683701 2.079998e-01 0.682 0 0
Iron uptake and transport R-HSA-917937 2.080032e-01 0.682 0 0
Toll-like Receptor Cascades R-HSA-168898 2.086746e-01 0.681 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.097986e-01 0.678 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.097986e-01 0.678 0 0
FasL/ CD95L signaling R-HSA-75157 2.121928e-01 0.673 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.121928e-01 0.673 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.121928e-01 0.673 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.121928e-01 0.673 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 2.121928e-01 0.673 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.121928e-01 0.673 0 0
Intracellular oxygen transport R-HSA-8981607 2.121928e-01 0.673 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.123343e-01 0.673 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.123343e-01 0.673 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.123343e-01 0.673 0 0
Signaling by NOTCH1 R-HSA-1980143 2.154333e-01 0.667 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.221242e-01 0.653 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.221242e-01 0.653 0 0
Metabolism of amino acids and derivatives R-HSA-71291 2.245851e-01 0.649 0 0
TBC/RABGAPs R-HSA-8854214 2.278738e-01 0.642 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.297545e-01 0.639 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.297545e-01 0.639 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.297545e-01 0.639 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.297545e-01 0.639 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.297545e-01 0.639 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.297545e-01 0.639 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 2.297545e-01 0.639 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 2.297545e-01 0.639 0 0
Signaling by Erythropoietin R-HSA-9006335 2.345888e-01 0.630 0 0
Platelet calcium homeostasis R-HSA-418360 2.345888e-01 0.630 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.345888e-01 0.630 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.354598e-01 0.628 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.441907e-01 0.612 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.460043e-01 0.609 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.471730e-01 0.607 0 0
DAP12 signaling R-HSA-2424491 2.471730e-01 0.607 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 2.471730e-01 0.607 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.472626e-01 0.607 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.472626e-01 0.607 0 0
Prolonged ERK activation events R-HSA-169893 2.472626e-01 0.607 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 2.472626e-01 0.607 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 2.472626e-01 0.607 0 0
Differentiation of T cells R-HSA-9945266 2.472626e-01 0.607 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.472626e-01 0.607 0 0
Somitogenesis R-HSA-9824272 2.481995e-01 0.605 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.488960e-01 0.604 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.488960e-01 0.604 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.488960e-01 0.604 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.488960e-01 0.604 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.488960e-01 0.604 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.488960e-01 0.604 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.488960e-01 0.604 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.488960e-01 0.604 0 0
Regulation of gap junction activity R-HSA-191650 2.488960e-01 0.604 0 0
NADE modulates death signalling R-HSA-205025 2.488960e-01 0.604 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.488960e-01 0.604 0 0
FCERI mediated NF-kB activation R-HSA-2871837 2.492740e-01 0.603 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 2.648126e-01 0.577 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.648126e-01 0.577 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.648126e-01 0.577 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.648126e-01 0.577 0 0
Response to metal ions R-HSA-5660526 2.648126e-01 0.577 0 0
Signaling by WNT in cancer R-HSA-4791275 2.726241e-01 0.564 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.726241e-01 0.564 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.785494e-01 0.555 0 0
ABC-family proteins mediated transport R-HSA-382556 2.815561e-01 0.550 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.823627e-01 0.549 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 2.823627e-01 0.549 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.823627e-01 0.549 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.838914e-01 0.547 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.838914e-01 0.547 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.838914e-01 0.547 0 0
G2 Phase R-HSA-68911 2.838914e-01 0.547 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.838914e-01 0.547 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.838914e-01 0.547 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.838914e-01 0.547 0 0
Suppression of autophagy R-HSA-9636569 2.838914e-01 0.547 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.838914e-01 0.547 0 0
Muscarinic acetylcholine receptors R-HSA-390648 2.838914e-01 0.547 0 0
Reelin signalling pathway R-HSA-8866376 2.838914e-01 0.547 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.838914e-01 0.547 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.854549e-01 0.544 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.854549e-01 0.544 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.858054e-01 0.544 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.889215e-01 0.539 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.898799e-01 0.538 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 2.939910e-01 0.532 0 0
Interleukin-1 family signaling R-HSA-446652 2.962411e-01 0.528 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.998749e-01 0.523 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.998749e-01 0.523 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.998749e-01 0.523 0 0
Azathioprine ADME R-HSA-9748787 3.004567e-01 0.522 0 0
eNOS activation R-HSA-203615 3.112414e-01 0.507 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.112696e-01 0.507 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.172583e-01 0.499 0 0
Plus-strand DNA synthesis R-HSA-164525 3.172583e-01 0.499 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.172583e-01 0.499 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.172583e-01 0.499 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.172583e-01 0.499 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.172583e-01 0.499 0 0
Pentose phosphate pathway disease R-HSA-6791465 3.172583e-01 0.499 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.172583e-01 0.499 0 0
Phosphorylation of Emi1 R-HSA-176417 3.172583e-01 0.499 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.172583e-01 0.499 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.172583e-01 0.499 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.173147e-01 0.499 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.173147e-01 0.499 0 0
Rap1 signalling R-HSA-392517 3.173147e-01 0.499 0 0
Other interleukin signaling R-HSA-449836 3.173147e-01 0.499 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.217317e-01 0.493 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.217317e-01 0.493 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.324118e-01 0.478 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.324118e-01 0.478 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 3.346508e-01 0.475 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.346508e-01 0.475 0 0
Protein hydroxylation R-HSA-9629569 3.346508e-01 0.475 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.346508e-01 0.475 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.370884e-01 0.472 0 0
GPVI-mediated activation cascade R-HSA-114604 3.370884e-01 0.472 0 0
G1/S-Specific Transcription R-HSA-69205 3.370884e-01 0.472 0 0
RUNX2 regulates bone development R-HSA-8941326 3.370884e-01 0.472 0 0
Ca2+ pathway R-HSA-4086398 3.443769e-01 0.463 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.490724e-01 0.457 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 3.490724e-01 0.457 0 0
Uncoating of the HIV Virion R-HSA-162585 3.490724e-01 0.457 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.490724e-01 0.457 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.490724e-01 0.457 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.490724e-01 0.457 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.490724e-01 0.457 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.490724e-01 0.457 0 0
NADPH regeneration R-HSA-389542 3.490724e-01 0.457 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.490724e-01 0.457 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.490724e-01 0.457 0 0
VLDL assembly R-HSA-8866423 3.490724e-01 0.457 0 0
Stimuli-sensing channels R-HSA-2672351 3.491603e-01 0.457 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 3.602344e-01 0.443 0 0
MET promotes cell motility R-HSA-8875878 3.628783e-01 0.440 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 3.630379e-01 0.440 0 0
Neddylation R-HSA-8951664 3.659396e-01 0.437 0 0
FCGR activation R-HSA-2029481 3.686183e-01 0.433 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.689024e-01 0.433 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.689024e-01 0.433 0 0
Ribavirin ADME R-HSA-9755088 3.689024e-01 0.433 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.757182e-01 0.425 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.757182e-01 0.425 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.794058e-01 0.421 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.794058e-01 0.421 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.794058e-01 0.421 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.794058e-01 0.421 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.794058e-01 0.421 0 0
LDL remodeling R-HSA-8964041 3.794058e-01 0.421 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.794058e-01 0.421 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.794058e-01 0.421 0 0
Netrin mediated repulsion signals R-HSA-418886 3.794058e-01 0.421 0 0
CHL1 interactions R-HSA-447041 3.794058e-01 0.421 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.794058e-01 0.421 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.794058e-01 0.421 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.857698e-01 0.414 0 0
Fructose metabolism R-HSA-5652084 3.857698e-01 0.414 0 0
Ethanol oxidation R-HSA-71384 3.857698e-01 0.414 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.857698e-01 0.414 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.857698e-01 0.414 0 0
Interleukin-2 family signaling R-HSA-451927 3.885048e-01 0.411 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 4.012264e-01 0.397 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.024373e-01 0.395 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.024373e-01 0.395 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.024373e-01 0.395 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.024373e-01 0.395 0 0
Reverse Transcription of HIV RNA R-HSA-162589 4.083275e-01 0.389 0 0
Minus-strand DNA synthesis R-HSA-164516 4.083275e-01 0.389 0 0
RSK activation R-HSA-444257 4.083275e-01 0.389 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.083275e-01 0.389 0 0
phospho-PLA2 pathway R-HSA-111995 4.083275e-01 0.389 0 0
Regulation by c-FLIP R-HSA-3371378 4.083275e-01 0.389 0 0
Activation of RAS in B cells R-HSA-1169092 4.083275e-01 0.389 0 0
Fructose biosynthesis R-HSA-5652227 4.083275e-01 0.389 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.083275e-01 0.389 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.083275e-01 0.389 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.083275e-01 0.389 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.083275e-01 0.389 0 0
Dimerization of procaspase-8 R-HSA-69416 4.083275e-01 0.389 0 0
Sodium/Proton exchangers R-HSA-425986 4.083275e-01 0.389 0 0
Adrenoceptors R-HSA-390696 4.083275e-01 0.389 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.083275e-01 0.389 0 0
Interleukin-23 signaling R-HSA-9020933 4.083275e-01 0.389 0 0
Mitochondrial RNA degradation R-HSA-9836573 4.188868e-01 0.378 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.188868e-01 0.378 0 0
Interleukin-6 family signaling R-HSA-6783589 4.188868e-01 0.378 0 0
Regulation of insulin secretion R-HSA-422356 4.189482e-01 0.378 0 0
Mitochondrial protein import R-HSA-1268020 4.283154e-01 0.368 0 0
Signaling by PDGF R-HSA-186797 4.283154e-01 0.368 0 0
Rab regulation of trafficking R-HSA-9007101 4.335912e-01 0.363 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.351025e-01 0.361 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.351025e-01 0.361 0 0
Hyaluronan degradation R-HSA-2160916 4.351025e-01 0.361 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.359030e-01 0.361 0 0
CASP8 activity is inhibited R-HSA-5218900 4.359030e-01 0.361 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.359030e-01 0.361 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.359030e-01 0.361 0 0
Interleukin-21 signaling R-HSA-9020958 4.359030e-01 0.361 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.359030e-01 0.361 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.359030e-01 0.361 0 0
WNT mediated activation of DVL R-HSA-201688 4.359030e-01 0.361 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.359030e-01 0.361 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.359030e-01 0.361 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.359030e-01 0.361 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 4.359030e-01 0.361 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.359030e-01 0.361 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.359030e-01 0.361 0 0
MET activates PTK2 signaling R-HSA-8874081 4.510704e-01 0.346 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.510704e-01 0.346 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.510704e-01 0.346 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.510704e-01 0.346 0 0
TRP channels R-HSA-3295583 4.510704e-01 0.346 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.510704e-01 0.346 0 0
DAP12 interactions R-HSA-2172127 4.512552e-01 0.346 0 0
Binding and entry of HIV virion R-HSA-173107 4.621949e-01 0.335 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.621949e-01 0.335 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.621949e-01 0.335 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 4.621949e-01 0.335 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.621949e-01 0.335 0 0
Interleukin-27 signaling R-HSA-9020956 4.621949e-01 0.335 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.621949e-01 0.335 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.635014e-01 0.334 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 4.640690e-01 0.333 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.649621e-01 0.333 0 0
Cristae formation R-HSA-8949613 4.667785e-01 0.331 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 4.667785e-01 0.331 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.667785e-01 0.331 0 0
Maturation of hRSV A proteins R-HSA-9828806 4.667785e-01 0.331 0 0
Leishmania infection R-HSA-9658195 4.675482e-01 0.330 0 0
Parasitic Infection Pathways R-HSA-9824443 4.675482e-01 0.330 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.756265e-01 0.323 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.801693e-01 0.319 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.822162e-01 0.317 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.822162e-01 0.317 0 0
Telomere Extension By Telomerase R-HSA-171319 4.822162e-01 0.317 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.822162e-01 0.317 0 0
Signaling by APC mutants R-HSA-4839744 4.872629e-01 0.312 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.872629e-01 0.312 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.872629e-01 0.312 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.872629e-01 0.312 0 0
vRNA Synthesis R-HSA-192814 4.872629e-01 0.312 0 0
vRNP Assembly R-HSA-192905 4.872629e-01 0.312 0 0
Chylomicron assembly R-HSA-8963888 4.872629e-01 0.312 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.872629e-01 0.312 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.872629e-01 0.312 0 0
Interleukin-2 signaling R-HSA-9020558 4.872629e-01 0.312 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.872629e-01 0.312 0 0
Transcription of the HIV genome R-HSA-167172 4.903264e-01 0.310 0 0
mRNA Capping R-HSA-72086 4.973748e-01 0.303 0 0
Thyroxine biosynthesis R-HSA-209968 4.973748e-01 0.303 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.973748e-01 0.303 0 0
DARPP-32 events R-HSA-180024 4.973748e-01 0.303 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.004007e-01 0.301 0 0
Neurotransmitter release cycle R-HSA-112310 5.097901e-01 0.293 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.111639e-01 0.291 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.111639e-01 0.291 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.111639e-01 0.291 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.111639e-01 0.291 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.111639e-01 0.291 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.111639e-01 0.291 0 0
Signaling by AXIN mutants R-HSA-4839735 5.111639e-01 0.291 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.111639e-01 0.291 0 0
Activation of RAC1 R-HSA-428540 5.111639e-01 0.291 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.111639e-01 0.291 0 0
Integration of provirus R-HSA-162592 5.111639e-01 0.291 0 0
Activation of the pre-replicative complex R-HSA-68962 5.122466e-01 0.291 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.122466e-01 0.291 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.122466e-01 0.291 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.227815e-01 0.282 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 5.268256e-01 0.278 0 0
IRE1alpha activates chaperones R-HSA-381070 5.272962e-01 0.278 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.300826e-01 0.276 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.339522e-01 0.272 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.339522e-01 0.272 0 0
Regulation of IFNG signaling R-HSA-877312 5.339522e-01 0.272 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.339522e-01 0.272 0 0
Interleukin-35 Signalling R-HSA-8984722 5.339522e-01 0.272 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.339522e-01 0.272 0 0
Signaling by LTK R-HSA-9842663 5.339522e-01 0.272 0 0
MET activates RAS signaling R-HSA-8851805 5.339522e-01 0.272 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.339522e-01 0.272 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.339522e-01 0.272 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.339522e-01 0.272 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.339522e-01 0.272 0 0
OAS antiviral response R-HSA-8983711 5.339522e-01 0.272 0 0
The phototransduction cascade R-HSA-2514856 5.342044e-01 0.272 0 0
Asparagine N-linked glycosylation R-HSA-446203 5.414475e-01 0.266 0 0
Neurexins and neuroligins R-HSA-6794361 5.454710e-01 0.263 0 0
tRNA processing R-HSA-72306 5.469750e-01 0.262 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.493809e-01 0.260 0 0
Signaling by FGFR in disease R-HSA-1226099 5.493809e-01 0.260 0 0
Potential therapeutics for SARS R-HSA-9679191 5.495119e-01 0.260 0 0
Mitochondrial protein degradation R-HSA-9837999 5.530227e-01 0.257 0 0
Collagen formation R-HSA-1474290 5.530227e-01 0.257 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.550858e-01 0.256 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.550858e-01 0.256 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.550858e-01 0.256 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.556794e-01 0.255 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.556794e-01 0.255 0 0
Processing of SMDT1 R-HSA-8949664 5.556794e-01 0.255 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.556794e-01 0.255 0 0
Frs2-mediated activation R-HSA-170968 5.556794e-01 0.255 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.556794e-01 0.255 0 0
Formation of axial mesoderm R-HSA-9796292 5.556794e-01 0.255 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.556794e-01 0.255 0 0
Nucleotide biosynthesis R-HSA-8956320 5.565770e-01 0.254 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.687602e-01 0.245 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.763949e-01 0.239 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.763949e-01 0.239 0 0
Hydrolysis of LPC R-HSA-1483115 5.763949e-01 0.239 0 0
Prolactin receptor signaling R-HSA-1170546 5.763949e-01 0.239 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 5.763949e-01 0.239 0 0
Malate-aspartate shuttle R-HSA-9856872 5.763949e-01 0.239 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.763949e-01 0.239 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.763949e-01 0.239 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.763949e-01 0.239 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.775267e-01 0.238 0 0
Translation of Structural Proteins R-HSA-9694635 5.775267e-01 0.238 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 5.821280e-01 0.235 0 0
Hyaluronan metabolism R-HSA-2142845 5.821280e-01 0.235 0 0
Signal amplification R-HSA-392518 5.821280e-01 0.235 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.951879e-01 0.225 0 0
PERK regulates gene expression R-HSA-381042 5.951879e-01 0.225 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.957239e-01 0.225 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.961459e-01 0.225 0 0
IRS-mediated signalling R-HSA-112399 5.993279e-01 0.222 0 0
Dectin-2 family R-HSA-5621480 5.993279e-01 0.222 0 0
Extracellular matrix organization R-HSA-1474244 6.064498e-01 0.217 0 0
Triglyceride catabolism R-HSA-163560 6.079397e-01 0.216 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.079397e-01 0.216 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.145781e-01 0.211 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.149771e-01 0.211 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 6.149771e-01 0.211 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.149771e-01 0.211 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.149771e-01 0.211 0 0
Phosphorylation of the APC/C R-HSA-176412 6.149771e-01 0.211 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.149771e-01 0.211 0 0
Fructose catabolism R-HSA-70350 6.149771e-01 0.211 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.149771e-01 0.211 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.149771e-01 0.211 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 6.196626e-01 0.208 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.203836e-01 0.207 0 0
tRNA Aminoacylation R-HSA-379724 6.295632e-01 0.201 0 0
Metabolism of polyamines R-HSA-351202 6.295632e-01 0.201 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.325207e-01 0.199 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.329313e-01 0.199 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 6.329313e-01 0.199 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.329313e-01 0.199 0 0
Galactose catabolism R-HSA-70370 6.329313e-01 0.199 0 0
Disorders of Developmental Biology R-HSA-9675151 6.329313e-01 0.199 0 0
Keratinization R-HSA-6805567 6.364075e-01 0.196 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.392843e-01 0.194 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.443524e-01 0.191 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.443524e-01 0.191 0 0
Heme signaling R-HSA-9707616 6.488251e-01 0.188 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.500493e-01 0.187 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.500493e-01 0.187 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.500493e-01 0.187 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.500493e-01 0.187 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.500493e-01 0.187 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.558809e-01 0.183 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 6.558809e-01 0.183 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 6.558809e-01 0.183 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.581850e-01 0.182 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 6.636357e-01 0.178 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.636357e-01 0.178 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 6.638060e-01 0.178 0 0
Mismatch Repair R-HSA-5358508 6.663700e-01 0.176 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.663700e-01 0.176 0 0
Platelet sensitization by LDL R-HSA-432142 6.663700e-01 0.176 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.663700e-01 0.176 0 0
Tie2 Signaling R-HSA-210993 6.663700e-01 0.176 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.663700e-01 0.176 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.663700e-01 0.176 0 0
IGF1R signaling cascade R-HSA-2428924 6.673637e-01 0.176 0 0
Insulin receptor signalling cascade R-HSA-74751 6.673637e-01 0.176 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.763612e-01 0.170 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.780389e-01 0.169 0 0
HIV Transcription Initiation R-HSA-167161 6.780389e-01 0.169 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.780389e-01 0.169 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.780389e-01 0.169 0 0
Cell surface interactions at the vascular wall R-HSA-202733 6.809563e-01 0.167 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.819305e-01 0.166 0 0
Specification of the neural plate border R-HSA-9834899 6.819305e-01 0.166 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.819305e-01 0.166 0 0
The NLRP3 inflammasome R-HSA-844456 6.819305e-01 0.166 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.819305e-01 0.166 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.819305e-01 0.166 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.819305e-01 0.166 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.819305e-01 0.166 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.886746e-01 0.162 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.886746e-01 0.162 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.894258e-01 0.162 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.967661e-01 0.157 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.967661e-01 0.157 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.967661e-01 0.157 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.967661e-01 0.157 0 0
Formation of definitive endoderm R-HSA-9823730 6.967661e-01 0.157 0 0
Pregnenolone biosynthesis R-HSA-196108 6.967661e-01 0.157 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.967661e-01 0.157 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.990195e-01 0.156 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 7.022695e-01 0.153 0 0
Amine ligand-binding receptors R-HSA-375280 7.090778e-01 0.149 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.109107e-01 0.148 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.109107e-01 0.148 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.109107e-01 0.148 0 0
ERK/MAPK targets R-HSA-198753 7.109107e-01 0.148 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.109107e-01 0.148 0 0
Acyl chain remodelling of PG R-HSA-1482925 7.109107e-01 0.148 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.163399e-01 0.145 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.188535e-01 0.143 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.233494e-01 0.141 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.243962e-01 0.140 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.243962e-01 0.140 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.372535e-01 0.132 0 0
Notch-HLH transcription pathway R-HSA-350054 7.372535e-01 0.132 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.372535e-01 0.132 0 0
LDL clearance R-HSA-8964038 7.372535e-01 0.132 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.372535e-01 0.132 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.372535e-01 0.132 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.372535e-01 0.132 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.375754e-01 0.132 0 0
NGF-stimulated transcription R-HSA-9031628 7.465311e-01 0.127 0 0
Mitochondrial biogenesis R-HSA-1592230 7.478695e-01 0.126 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.495117e-01 0.125 0 0
Biosynthesis of maresins R-HSA-9018682 7.495117e-01 0.125 0 0
Interleukin-20 family signaling R-HSA-8854691 7.495117e-01 0.125 0 0
Mitochondrial mRNA modification R-HSA-9937008 7.495117e-01 0.125 0 0
CYP2E1 reactions R-HSA-211999 7.611988e-01 0.119 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.611988e-01 0.119 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.611988e-01 0.119 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.611988e-01 0.119 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.611988e-01 0.119 0 0
Complex III assembly R-HSA-9865881 7.611988e-01 0.119 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.611988e-01 0.119 0 0
PI3K Cascade R-HSA-109704 7.636568e-01 0.117 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.723412e-01 0.112 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.723412e-01 0.112 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 7.723412e-01 0.112 0 0
Formation of the nephric duct R-HSA-9830364 7.723412e-01 0.112 0 0
Laminin interactions R-HSA-3000157 7.723412e-01 0.112 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.723412e-01 0.112 0 0
G alpha (12/13) signalling events R-HSA-416482 7.771910e-01 0.109 0 0
Metabolism of nucleotides R-HSA-15869 7.775520e-01 0.109 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.829644e-01 0.106 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.829644e-01 0.106 0 0
Urea cycle R-HSA-70635 7.829644e-01 0.106 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.829644e-01 0.106 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.829644e-01 0.106 0 0
PI Metabolism R-HSA-1483255 7.864397e-01 0.104 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.874587e-01 0.104 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.930924e-01 0.101 0 0
Insulin processing R-HSA-264876 7.930924e-01 0.101 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.930924e-01 0.101 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.964050e-01 0.099 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.027485e-01 0.095 0 0
Inflammasomes R-HSA-622312 8.027485e-01 0.095 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.027485e-01 0.095 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.087865e-01 0.092 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.087865e-01 0.092 0 0
Metabolism of amine-derived hormones R-HSA-209776 8.091245e-01 0.092 0 0
NRAGE signals death through JNK R-HSA-193648 8.091245e-01 0.092 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.119544e-01 0.090 0 0
Platelet homeostasis R-HSA-418346 8.133955e-01 0.090 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.207313e-01 0.086 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.207313e-01 0.086 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.207313e-01 0.086 0 0
Neurotransmitter clearance R-HSA-112311 8.207313e-01 0.086 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.207313e-01 0.086 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.207313e-01 0.086 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.224537e-01 0.085 0 0
Bacterial Infection Pathways R-HSA-9824439 8.252626e-01 0.083 0 0
Extension of Telomeres R-HSA-180786 8.288000e-01 0.082 0 0
Triglyceride metabolism R-HSA-8979227 8.288000e-01 0.082 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.290990e-01 0.081 0 0
Cardiac conduction R-HSA-5576891 8.292495e-01 0.081 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.306873e-01 0.081 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.370766e-01 0.077 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.370766e-01 0.077 0 0
Nuclear RNA decay R-HSA-9930044 8.446822e-01 0.073 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.446822e-01 0.073 0 0
Cardiogenesis R-HSA-9733709 8.446822e-01 0.073 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.446822e-01 0.073 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.466299e-01 0.072 0 0
Interferon gamma signaling R-HSA-877300 8.474232e-01 0.072 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.519333e-01 0.070 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.519333e-01 0.070 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.519333e-01 0.070 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.588463e-01 0.066 0 0
Signaling by Insulin receptor R-HSA-74752 8.643081e-01 0.063 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.654369e-01 0.063 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.654369e-01 0.063 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.654369e-01 0.063 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 8.654369e-01 0.063 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.717201e-01 0.060 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.726277e-01 0.059 0 0
O-linked glycosylation of mucins R-HSA-913709 8.773147e-01 0.057 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.777104e-01 0.057 0 0
Collagen chain trimerization R-HSA-8948216 8.777104e-01 0.057 0 0
Metabolism of folate and pterines R-HSA-196757 8.777104e-01 0.057 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 8.783448e-01 0.056 0 0
Elastic fibre formation R-HSA-1566948 8.834213e-01 0.054 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.834213e-01 0.054 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 8.845881e-01 0.053 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.845881e-01 0.053 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.888658e-01 0.051 0 0
Metabolism of cofactors R-HSA-8978934 8.904370e-01 0.050 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.940563e-01 0.049 0 0
Diseases of Immune System R-HSA-5260271 8.940563e-01 0.049 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.990047e-01 0.046 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.990047e-01 0.046 0 0
Gastrulation R-HSA-9758941 8.995306e-01 0.046 0 0
Intra-Golgi traffic R-HSA-6811438 9.037223e-01 0.044 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.037223e-01 0.044 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.059115e-01 0.043 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.075535e-01 0.042 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.082198e-01 0.042 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.082198e-01 0.042 0 0
PPARA activates gene expression R-HSA-1989781 9.150112e-01 0.039 0 0
Methylation R-HSA-156581 9.165951e-01 0.038 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.165951e-01 0.038 0 0
Surfactant metabolism R-HSA-5683826 9.165951e-01 0.038 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.196843e-01 0.036 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.242069e-01 0.034 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.242069e-01 0.034 0 0
Diseases of DNA repair R-HSA-9675135 9.242069e-01 0.034 0 0
Signaling by TGFBR3 R-HSA-9839373 9.242069e-01 0.034 0 0
G alpha (q) signalling events R-HSA-416476 9.244750e-01 0.034 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.277486e-01 0.033 0 0
Synthesis of PC R-HSA-1483191 9.277486e-01 0.033 0 0
GPER1 signaling R-HSA-9634597 9.311250e-01 0.031 0 0
Metal ion SLC transporters R-HSA-425410 9.311250e-01 0.031 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.311250e-01 0.031 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.347910e-01 0.029 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.374123e-01 0.028 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.451652e-01 0.024 0 0
Glucuronidation R-HSA-156588 9.483193e-01 0.023 0 0
Paracetamol ADME R-HSA-9753281 9.507354e-01 0.022 0 0
Synthesis of PA R-HSA-1483166 9.552345e-01 0.020 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.573277e-01 0.019 0 0
Regulation of beta-cell development R-HSA-186712 9.593231e-01 0.018 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.593231e-01 0.018 0 0
Collagen degradation R-HSA-1442490 9.630388e-01 0.016 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.661629e-01 0.015 0 0
Complex I biogenesis R-HSA-6799198 9.664154e-01 0.015 0 0
Xenobiotics R-HSA-211981 9.679864e-01 0.014 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.679864e-01 0.014 0 0
Adipogenesis R-HSA-9843745 9.711117e-01 0.013 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.722725e-01 0.012 0 0
Kidney development R-HSA-9830369 9.722725e-01 0.012 0 0
Metabolism of steroid hormones R-HSA-196071 9.722725e-01 0.012 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.759853e-01 0.011 0 0
COPII-mediated vesicle transport R-HSA-204005 9.759853e-01 0.011 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.771091e-01 0.010 0 0
ECM proteoglycans R-HSA-3000178 9.771091e-01 0.010 0 0
Aspirin ADME R-HSA-9749641 9.792016e-01 0.009 0 0
Integrin cell surface interactions R-HSA-216083 9.836346e-01 0.007 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.837587e-01 0.007 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.844008e-01 0.007 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.844008e-01 0.007 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.850464e-01 0.007 0 0
Visual phototransduction R-HSA-2187338 9.851270e-01 0.007 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.858275e-01 0.006 0 0
Peptide hormone metabolism R-HSA-2980736 9.862345e-01 0.006 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.871237e-01 0.006 0 0
Arachidonate metabolism R-HSA-2142753 9.876753e-01 0.005 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.877268e-01 0.005 0 0
Drug ADME R-HSA-9748784 9.885363e-01 0.005 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.893719e-01 0.005 0 0
G alpha (i) signalling events R-HSA-418594 9.919977e-01 0.003 0 0
Potassium Channels R-HSA-1296071 9.940250e-01 0.003 0 0
G alpha (s) signalling events R-HSA-418555 9.942656e-01 0.002 0 0
O-linked glycosylation R-HSA-5173105 9.947523e-01 0.002 0 0
Transport of small molecules R-HSA-382551 9.947938e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.948266e-01 0.002 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.961219e-01 0.002 0 0
GPCR downstream signalling R-HSA-388396 9.969491e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.970932e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.971555e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.972296e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.974356e-01 0.001 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.980316e-01 0.001 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.985629e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.991676e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.991757e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.995549e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.995727e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.995758e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.996823e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997250e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.997338e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.998601e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999208e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999413e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999471e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999885e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999899e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999937e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999978e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways