CAMK1B

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
O43432	S1156	SIGNOR\|EPSD\|PSP	EIF4G3	KNDKPLPSATARPNTFMRGGssKDLLDNQsQEEQRREMLET
O95714	S2928	Sugiyama	HERC2	ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07900	S391	EPSD\|PSP	HSP90AA1 HSP90A HSPC1 HSPCA	MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	T624	EPSD\|PSP	HSP90AA1 HSP90A HSPC1 HSPCA	yGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsIIE
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	T89	EPSD\|PSP	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P29692	S133	Sugiyama	EEF1D EF1D	NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P32119	T142	Sugiyama	PRDX2 NKEFB TDPX1	EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363	S439	Sugiyama	TUBA1B	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q13769	S314	Sugiyama	THOC5 C22orf19 KIAA0983	VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q14157	S609	Sugiyama	UBAP2L KIAA0144 NICE4	GPLYEQRSTQTRRyPssIsssPQKDLtQAKNGFSSVQATQL
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q6P2M8	S13	Sugiyama	PNCK	________MLLLKKHtEDISsVYEIRERLGSGAFSEVVLAQ
Q6P2M8	S323	Sugiyama	PNCK	ATSFLRHIRKLGQIPEGEGAsEQGMARHSHsGLRAGQPPKW
Q6P2M8	S333	Sugiyama	PNCK	LGQIPEGEGAsEQGMARHSHsGLRAGQPPKW__________
Q6P2M8	T8	Sugiyama	PNCK	_____________MLLLKKHtEDISsVYEIRERLGSGAFSE
Q71U36	S439	Sugiyama	TUBA1A TUBA3	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q9H7D7	S121	Sugiyama	WDR26 CDW2 MIP2 PRO0852	ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9UPU5	S2047	Sugiyama	USP24 KIAA1057	VRRRYWNAYMLFYQRVSDQNsPVLPKKSRVSVVRQEAEDLs

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Chromatin modifying enzymes	R-HSA-3247509	1.454127e-09	8.837
Chromatin organization	R-HSA-4839726	7.816437e-09	8.107
Cell Cycle	R-HSA-1640170	2.614675e-08	7.583
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	4.937289e-08	7.307
Cell Cycle Checkpoints	R-HSA-69620	6.136160e-08	7.212
Signal Transduction	R-HSA-162582	2.198920e-07	6.658
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.980177e-07	6.223
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.370238e-07	6.196
NRAGE signals death through JNK	R-HSA-193648	6.827705e-07	6.166
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	9.987741e-07	6.001
G alpha (12/13) signalling events	R-HSA-416482	1.265926e-06	5.898
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.294947e-06	5.888
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.783807e-06	5.749
Cell Cycle, Mitotic	R-HSA-69278	1.950244e-06	5.710
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.725403e-06	5.326
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.018022e-05	4.992
Cellular Senescence	R-HSA-2559583	1.249010e-05	4.903
p75 NTR receptor-mediated signalling	R-HSA-193704	1.376666e-05	4.861
Regulation of TP53 Activity	R-HSA-5633007	2.017348e-05	4.695
Meiotic synapsis	R-HSA-1221632	2.253016e-05	4.647
G2/M DNA damage checkpoint	R-HSA-69473	2.355760e-05	4.628
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.740650e-05	4.562
Apoptotic execution phase	R-HSA-75153	2.916645e-05	4.535
DNA Double Strand Break Response	R-HSA-5693606	3.285767e-05	4.483
Death Receptor Signaling	R-HSA-73887	3.412888e-05	4.467
Processing of DNA double-strand break ends	R-HSA-5693607	4.080583e-05	4.389
Intracellular signaling by second messengers	R-HSA-9006925	4.974672e-05	4.303
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	5.856073e-05	4.232
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.696217e-05	4.174
HATs acetylate histones	R-HSA-3214847	7.008476e-05	4.154
Diseases of programmed cell death	R-HSA-9645723	7.972130e-05	4.098
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.167473e-04	3.933
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.250691e-04	3.903
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.250691e-04	3.903
G2/M Checkpoints	R-HSA-69481	1.211466e-04	3.917
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.395201e-04	3.855
Packaging Of Telomere Ends	R-HSA-171306	1.634619e-04	3.787
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.715929e-04	3.766
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.822148e-04	3.739
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.822148e-04	3.739
Meiosis	R-HSA-1500620	1.982434e-04	3.703
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.974499e-04	3.705
Cell-Cell communication	R-HSA-1500931	2.340339e-04	3.631
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.350706e-04	3.629
Oxidative Stress Induced Senescence	R-HSA-2559580	2.433549e-04	3.614
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.532655e-04	3.596
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.904222e-04	3.537
DNA methylation	R-HSA-5334118	3.021735e-04	3.520
PKMTs methylate histone lysines	R-HSA-3214841	3.924819e-04	3.406
Cell junction organization	R-HSA-446728	3.842399e-04	3.415
Reproduction	R-HSA-1474165	4.054416e-04	3.392
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.717574e-04	3.326
Nucleosome assembly	R-HSA-774815	4.717574e-04	3.326
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	4.672800e-04	3.330
Homology Directed Repair	R-HSA-5693538	4.584689e-04	3.339
RNA Polymerase I Promoter Opening	R-HSA-73728	5.206220e-04	3.283
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.720028e-04	3.243
HDACs deacetylate histones	R-HSA-3214815	6.200219e-04	3.208
Diseases of mitotic cell cycle	R-HSA-9675126	6.945001e-04	3.158
DNA Double-Strand Break Repair	R-HSA-5693532	7.065596e-04	3.151
Ion homeostasis	R-HSA-5578775	7.533883e-04	3.123
Transcriptional regulation by RUNX1	R-HSA-8878171	7.684610e-04	3.114
Rab regulation of trafficking	R-HSA-9007101	7.735586e-04	3.112
Defective pyroptosis	R-HSA-9710421	7.795384e-04	3.108
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	8.237624e-04	3.084
PRC2 methylates histones and DNA	R-HSA-212300	8.681436e-04	3.061
Inhibition of DNA recombination at telomere	R-HSA-9670095	8.275098e-04	3.082
PI3K/AKT Signaling in Cancer	R-HSA-2219528	8.790592e-04	3.056
HDMs demethylate histones	R-HSA-3214842	8.978014e-04	3.047
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.972006e-04	3.047
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	8.640520e-04	3.063
Axon guidance	R-HSA-422475	9.275148e-04	3.033
Amplification of signal from the kinetochores	R-HSA-141424	1.069031e-03	2.971
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.069031e-03	2.971
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.034777e-03	2.985
Cleavage of the damaged purine	R-HSA-110331	1.096923e-03	2.960
DAG and IP3 signaling	R-HSA-1489509	1.189843e-03	2.925
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.251870e-03	2.902
M Phase	R-HSA-68886	1.267428e-03	2.897
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.358363e-03	2.867
Depurination	R-HSA-73927	1.374747e-03	2.862
Condensation of Prophase Chromosomes	R-HSA-2299718	1.455975e-03	2.837
Transcriptional Regulation by TP53	R-HSA-3700989	1.457671e-03	2.836
Mitotic Spindle Checkpoint	R-HSA-69618	1.480143e-03	2.830
Cleavage of the damaged pyrimidine	R-HSA-110329	1.583630e-03	2.800
Depyrimidination	R-HSA-73928	1.583630e-03	2.800
Meiotic recombination	R-HSA-912446	1.608780e-03	2.794
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.709583e-03	2.767
Apoptosis	R-HSA-109581	1.836164e-03	2.736
Oncogenic MAPK signaling	R-HSA-6802957	1.879765e-03	2.726
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.110215e-03	2.676
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.111411e-03	2.675
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.164477e-03	2.665
Signaling by ALK in cancer	R-HSA-9700206	2.164477e-03	2.665
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.314871e-03	2.635
Calmodulin induced events	R-HSA-111933	2.277828e-03	2.642
CaM pathway	R-HSA-111997	2.277828e-03	2.642
PIP3 activates AKT signaling	R-HSA-1257604	2.336930e-03	2.631
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.391395e-03	2.621
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.678126e-03	2.572
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.678126e-03	2.572
Nervous system development	R-HSA-9675108	2.669775e-03	2.574
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.678126e-03	2.572
Estrogen-dependent gene expression	R-HSA-9018519	2.997479e-03	2.523
Regulation of TP53 Expression	R-HSA-6804754	3.134362e-03	2.504
TCF dependent signaling in response to WNT	R-HSA-201681	3.183707e-03	2.497
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.243012e-03	2.489
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	3.430027e-03	2.465
Signaling downstream of RAS mutants	R-HSA-9649948	3.430027e-03	2.465
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	3.430027e-03	2.465
Signaling by RAS mutants	R-HSA-6802949	3.430027e-03	2.465
TRP channels	R-HSA-3295583	3.408689e-03	2.467
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.528332e-03	2.452
Assembly of the pre-replicative complex	R-HSA-68867	3.686091e-03	2.433
Mitotic Prophase	R-HSA-68875	3.722568e-03	2.429
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.561505e-03	2.448
RAF activation	R-HSA-5673000	3.762471e-03	2.425
Cell-cell junction organization	R-HSA-421270	3.861718e-03	2.413
Adherens junctions interactions	R-HSA-418990	4.058485e-03	2.392
NoRC negatively regulates rRNA expression	R-HSA-427413	4.176169e-03	2.379
Transcriptional Regulation by E2F6	R-HSA-8953750	4.206436e-03	2.376
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.243133e-03	2.372
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.243133e-03	2.372
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.620372e-03	2.335
ESR-mediated signaling	R-HSA-8939211	4.799578e-03	2.319
Base-Excision Repair, AP Site Formation	R-HSA-73929	5.986645e-03	2.223
Signaling by Hippo	R-HSA-2028269	6.109405e-03	2.214
Specification of primordial germ cells	R-HSA-9827857	6.109405e-03	2.214
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.192129e-03	2.208
Regulation of MECP2 expression and activity	R-HSA-9022692	6.192129e-03	2.208
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.254160e-03	2.204
SIRT1 negatively regulates rRNA expression	R-HSA-427359	6.809372e-03	2.167
RNA Polymerase II Transcription	R-HSA-73857	6.349814e-03	2.197
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	6.360251e-03	2.197
Signaling by VEGF	R-HSA-194138	6.933252e-03	2.159
Epigenetic regulation of gene expression	R-HSA-212165	7.055350e-03	2.151
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	7.156247e-03	2.145
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	7.156247e-03	2.145
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	7.156247e-03	2.145
Regulation of CDH19 Expression and Function	R-HSA-9764302	7.156247e-03	2.145
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.161407e-03	2.145
Long-term potentiation	R-HSA-9620244	7.286776e-03	2.137
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.177911e-03	2.087
DNA Replication Pre-Initiation	R-HSA-69002	8.785688e-03	2.056
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	8.257268e-03	2.083
Ca-dependent events	R-HSA-111996	8.657382e-03	2.063
Programmed Cell Death	R-HSA-5357801	8.405477e-03	2.075
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.741586e-03	2.058
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	9.001008e-03	2.046
RNA Polymerase I Promoter Escape	R-HSA-73772	9.245982e-03	2.034
Post NMDA receptor activation events	R-HSA-438064	1.010960e-02	1.995
Signaling by ROBO receptors	R-HSA-376176	1.023497e-02	1.990
Gene expression (Transcription)	R-HSA-74160	1.031708e-02	1.986
Germ layer formation at gastrulation	R-HSA-9754189	1.037066e-02	1.984
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.038215e-02	1.984
Signaling by LTK	R-HSA-9842663	1.050241e-02	1.979
Co-stimulation by CD28	R-HSA-389356	1.052743e-02	1.978
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.067983e-02	1.971
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.119777e-02	1.951
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.145584e-02	1.941
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.261992e-02	1.899
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.261992e-02	1.899
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.261992e-02	1.899
mRNA Splicing - Major Pathway	R-HSA-72163	1.215424e-02	1.915
mRNA Splicing	R-HSA-72172	1.183107e-02	1.927
G0 and Early G1	R-HSA-1538133	1.227396e-02	1.911
Regulation of TP53 Degradation	R-HSA-6804757	1.306627e-02	1.884
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.319475e-02	1.880
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.319475e-02	1.880
Cardiac conduction	R-HSA-5576891	1.330759e-02	1.876
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.362004e-02	1.866
FLT3 Signaling	R-HSA-9607240	1.362004e-02	1.866
Response of endothelial cells to shear stress	R-HSA-9860931	1.412505e-02	1.850
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.419175e-02	1.848
Kinesins	R-HSA-983189	1.419175e-02	1.848
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.419204e-02	1.848
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.453735e-02	1.838
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.472744e-02	1.832
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.546733e-02	1.811
Signaling by RAF1 mutants	R-HSA-9656223	1.594933e-02	1.797
DARPP-32 events	R-HSA-180024	1.654017e-02	1.781
PLC beta mediated events	R-HSA-112043	1.616149e-02	1.792
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.724335e-02	1.763
Generic Transcription Pathway	R-HSA-212436	1.730812e-02	1.762
Signaling by WNT	R-HSA-195721	1.814483e-02	1.741
Sema4D in semaphorin signaling	R-HSA-400685	1.848118e-02	1.733
mRNA 3'-end processing	R-HSA-72187	1.872800e-02	1.728
Neurexins and neuroligins	R-HSA-6794361	1.872800e-02	1.728
RNA Polymerase I Transcription	R-HSA-73864	1.921270e-02	1.716
Interleukin-37 signaling	R-HSA-9008059	1.983479e-02	1.703
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.049559e-02	1.688
Semaphorin interactions	R-HSA-373755	2.073345e-02	1.683
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.087094e-02	1.680
TBC/RABGAPs	R-HSA-8854214	2.150839e-02	1.667
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.152179e-02	1.667
Cellular responses to stimuli	R-HSA-8953897	2.177731e-02	1.662
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	2.199784e-02	1.658
Type I hemidesmosome assembly	R-HSA-446107	2.469595e-02	1.607
Beta-catenin phosphorylation cascade	R-HSA-196299	2.418671e-02	1.616
PKA activation in glucagon signalling	R-HSA-164378	2.247087e-02	1.648
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.357276e-02	1.628
Protein-protein interactions at synapses	R-HSA-6794362	2.299587e-02	1.638
Cellular responses to mechanical stimuli	R-HSA-9855142	2.365020e-02	1.626
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.469595e-02	1.607
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.476744e-02	1.606
EPHB-mediated forward signaling	R-HSA-3928662	2.478032e-02	1.606
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.507402e-02	1.601
Activation of RAC1	R-HSA-428540	2.521370e-02	1.598
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.521370e-02	1.598
Signaling by GSK3beta mutants	R-HSA-5339716	2.521370e-02	1.598
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.679231e-02	1.572
Signaling by ERBB2	R-HSA-1227986	2.694142e-02	1.570
Hedgehog 'off' state	R-HSA-5610787	2.712902e-02	1.567
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.744033e-02	1.562
The NLRP3 inflammasome	R-HSA-844456	2.789985e-02	1.554
RET signaling	R-HSA-8853659	2.837845e-02	1.547
CLEC7A/inflammasome pathway	R-HSA-5660668	3.180551e-02	1.497
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.180551e-02	1.497
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	3.294503e-02	1.482
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.294503e-02	1.482
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.294503e-02	1.482
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.294503e-02	1.482
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.294503e-02	1.482
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.294503e-02	1.482
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.161503e-02	1.500
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.143090e-02	1.503
Chromosome Maintenance	R-HSA-73886	3.143090e-02	1.503
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.033406e-02	1.518
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.988664e-02	1.525
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.988664e-02	1.525
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.988664e-02	1.525
G-protein mediated events	R-HSA-112040	3.277296e-02	1.484
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.389905e-02	1.470
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.395069e-02	1.469
Regulated proteolysis of p75NTR	R-HSA-193692	3.395069e-02	1.469
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.395069e-02	1.469
Regulation of T cell activation by CD28 family	R-HSA-388841	3.408667e-02	1.467
Nephrin family interactions	R-HSA-373753	3.417411e-02	1.466
Membrane Trafficking	R-HSA-199991	3.425294e-02	1.465
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.496959e-02	1.456
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	3.568045e-02	1.448
Diseases of Telomere Maintenance	R-HSA-9673013	3.568045e-02	1.448
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	3.568045e-02	1.448
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	3.568045e-02	1.448
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	3.568045e-02	1.448
Formation of RNA Pol II elongation complex	R-HSA-112382	3.595318e-02	1.444
Neurodegenerative Diseases	R-HSA-8863678	3.631794e-02	1.440
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.631794e-02	1.440
MTOR signalling	R-HSA-165159	3.747847e-02	1.426
Cellular responses to stress	R-HSA-2262752	3.761862e-02	1.425
S Phase	R-HSA-69242	3.775239e-02	1.423
G1/S DNA Damage Checkpoints	R-HSA-69615	3.783496e-02	1.422
Mitotic G2-G2/M phases	R-HSA-453274	3.832955e-02	1.416
Opioid Signalling	R-HSA-111885	3.842782e-02	1.415
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.044835e-02	1.393
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.092995e-02	1.388
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.206770e-02	1.376
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	4.206770e-02	1.376
Signaling by SCF-KIT	R-HSA-1433557	4.262634e-02	1.370
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.379563e-02	1.359
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.383956e-02	1.358
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	5.060079e-02	1.296
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	4.472958e-02	1.349
Regulation of endogenous retroelements	R-HSA-9842860	5.162937e-02	1.287
Regulation of NFE2L2 gene expression	R-HSA-9818749	4.554135e-02	1.342
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.162937e-02	1.287
Mitotic Prometaphase	R-HSA-68877	5.151032e-02	1.288
Netrin-1 signaling	R-HSA-373752	4.825023e-02	1.317
Separation of Sister Chromatids	R-HSA-2467813	5.017462e-02	1.300
DNA Repair	R-HSA-73894	4.794363e-02	1.319
Mitotic Anaphase	R-HSA-68882	5.190200e-02	1.285
RNA Polymerase II Transcription Termination	R-HSA-73856	5.395252e-02	1.268
Telomere Maintenance	R-HSA-157579	5.444581e-02	1.264
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.475067e-02	1.262
VEGFR2 mediated vascular permeability	R-HSA-5218920	5.604306e-02	1.251
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.665895e-02	1.247
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	5.665895e-02	1.247
Synaptic adhesion-like molecules	R-HSA-8849932	5.665895e-02	1.247
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.665895e-02	1.247
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.693686e-02	1.245
Stimuli-sensing channels	R-HSA-2672351	5.706250e-02	1.244
Signaling by APC mutants	R-HSA-4839744	5.819453e-02	1.235
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	5.819453e-02	1.235
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	5.819453e-02	1.235
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	5.819453e-02	1.235
HSF1-dependent transactivation	R-HSA-3371571	5.867177e-02	1.232
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	5.870856e-02	1.231
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.895694e-02	1.229
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.952816e-02	1.225
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	6.006388e-02	1.221
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	6.006388e-02	1.221
MAPK family signaling cascades	R-HSA-5683057	6.035849e-02	1.219
Regulation of PD-L1(CD274) expression	R-HSA-9909648	6.039446e-02	1.219
Breakdown of the nuclear lamina	R-HSA-352238	7.300751e-02	1.137
Interactions of Tat with host cellular proteins	R-HSA-176034	7.300751e-02	1.137
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	7.300751e-02	1.137
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.209222e-02	1.207
RUNX3 regulates WNT signaling	R-HSA-8951430	6.209222e-02	1.207
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.209222e-02	1.207
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.209222e-02	1.207
DCC mediated attractive signaling	R-HSA-418885	6.468134e-02	1.189
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.468134e-02	1.189
Phase 0 - rapid depolarisation	R-HSA-5576892	6.815029e-02	1.167
Integrin signaling	R-HSA-354192	6.694587e-02	1.174
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.523309e-02	1.186
p75NTR signals via NF-kB	R-HSA-193639	6.468134e-02	1.189
Rap1 signalling	R-HSA-392517	6.765888e-02	1.170
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.513559e-02	1.186
NF-kB is activated and signals survival	R-HSA-209560	7.323679e-02	1.135
Ub-specific processing proteases	R-HSA-5689880	6.397147e-02	1.194
G2/M Transition	R-HSA-69275	6.781744e-02	1.169
Negative regulation of MAPK pathway	R-HSA-5675221	6.320481e-02	1.199
RAF/MAP kinase cascade	R-HSA-5673001	7.020993e-02	1.154
Signaling by AMER1 mutants	R-HSA-4839748	7.323679e-02	1.135
Signaling by AXIN mutants	R-HSA-4839735	7.323679e-02	1.135
Transcriptional Regulation by MECP2	R-HSA-8986944	7.109805e-02	1.148
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.781516e-02	1.169
Base Excision Repair	R-HSA-73884	6.568614e-02	1.183
Cyclin E associated events during G1/S transition	R-HSA-69202	7.499639e-02	1.125
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.499639e-02	1.125
XBP1(S) activates chaperone genes	R-HSA-381038	7.516443e-02	1.124
NGF-stimulated transcription	R-HSA-9031628	7.579820e-02	1.120
Effects of PIP2 hydrolysis	R-HSA-114508	7.612013e-02	1.119
Signaling by Erythropoietin	R-HSA-9006335	7.819282e-02	1.107
Late endosomal microautophagy	R-HSA-9615710	7.819282e-02	1.107
Regulation of gene expression in beta cells	R-HSA-210745	7.819282e-02	1.107
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.821024e-02	1.107
Differentiation of T cells	R-HSA-9945266	7.821024e-02	1.107
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	7.821024e-02	1.107
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	7.821024e-02	1.107
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	7.821024e-02	1.107
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.822364e-02	1.107
Muscle contraction	R-HSA-397014	7.861269e-02	1.105
Golgi-to-ER retrograde transport	R-HSA-8856688	7.864686e-02	1.104
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	7.948547e-02	1.100
ROBO receptors bind AKAP5	R-HSA-9010642	8.138122e-02	1.089
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	8.138122e-02	1.089
Adrenoceptors	R-HSA-390696	8.138122e-02	1.089
Co-stimulation by ICOS	R-HSA-9927354	8.138122e-02	1.089
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	8.138122e-02	1.089
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	8.271636e-02	1.082
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	8.590757e-02	1.066
SMAC (DIABLO) binds to IAPs	R-HSA-111463	8.590757e-02	1.066
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	8.590757e-02	1.066
G2 Phase	R-HSA-68911	8.590757e-02	1.066
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	8.590757e-02	1.066
NrCAM interactions	R-HSA-447038	8.590757e-02	1.066
AURKA Activation by TPX2	R-HSA-8854518	8.642596e-02	1.063
Transcriptional regulation by small RNAs	R-HSA-5578749	8.896452e-02	1.051
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	9.019150e-02	1.045
SHC-related events triggered by IGF1R	R-HSA-2428933	9.019150e-02	1.045
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	9.320704e-02	1.031
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.323470e-02	1.030
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.403332e-02	1.027
MAPK1/MAPK3 signaling	R-HSA-5684996	9.413648e-02	1.026
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.156099e-01	0.937
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.156099e-01	0.937
IkBA variant leads to EDA-ID	R-HSA-5603029	1.156099e-01	0.937
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	1.156099e-01	0.937
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.032563e-01	0.986
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.032563e-01	0.986
Inactivation of CDC42 and RAC1	R-HSA-428543	1.032563e-01	0.986
Calcineurin activates NFAT	R-HSA-2025928	1.032563e-01	0.986
G1/S-Specific Transcription	R-HSA-69205	1.081137e-01	0.966
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.138977e-01	0.943
G1/S Transition	R-HSA-69206	9.958408e-02	1.002
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.096342e-01	0.960
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.096342e-01	0.960
GP1b-IX-V activation signalling	R-HSA-430116	1.032563e-01	0.986
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	9.653533e-02	1.015
MAP2K and MAPK activation	R-HSA-5674135	1.138977e-01	0.943
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.174435e-01	0.930
Trafficking of AMPA receptors	R-HSA-399719	1.008378e-01	0.996
Signaling by FGFR1 in disease	R-HSA-5655302	1.138977e-01	0.943
DNA Replication	R-HSA-69306	1.051348e-01	0.978
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	9.770519e-02	1.010
PI Metabolism	R-HSA-1483255	1.179960e-01	0.928
Interleukin-1 processing	R-HSA-448706	1.032563e-01	0.986
Ion channel transport	R-HSA-983712	1.076773e-01	0.968
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.032563e-01	0.986
IRE1alpha activates chaperones	R-HSA-381070	1.166883e-01	0.933
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.181813e-01	0.927
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.181813e-01	0.927
Regulation of cortical dendrite branching	R-HSA-8985801	1.181813e-01	0.927
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.181813e-01	0.927
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.181813e-01	0.927
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.181813e-01	0.927
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.181813e-01	0.927
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.181813e-01	0.927
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.181813e-01	0.927
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.181813e-01	0.927
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.181813e-01	0.927
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.181813e-01	0.927
Potassium transport channels	R-HSA-1296067	1.181813e-01	0.927
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.186389e-01	0.926
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.186389e-01	0.926
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.186568e-01	0.926
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.222050e-01	0.913
MITF-M-dependent gene expression	R-HSA-9856651	1.233955e-01	0.909
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.234752e-01	0.908
mTORC1-mediated signalling	R-HSA-166208	1.234752e-01	0.908
EPH-Ephrin signaling	R-HSA-2682334	1.247485e-01	0.904
Transcriptional regulation by RUNX3	R-HSA-8878159	1.252948e-01	0.902
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.252948e-01	0.902
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	1.256010e-01	0.901
Activation of ATR in response to replication stress	R-HSA-176187	1.268455e-01	0.897
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.268455e-01	0.897
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.268455e-01	0.897
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.268455e-01	0.897
PKA activation	R-HSA-163615	1.274345e-01	0.895
Chaperone Mediated Autophagy	R-HSA-9613829	1.274345e-01	0.895
Polo-like kinase mediated events	R-HSA-156711	1.274345e-01	0.895
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.274345e-01	0.895
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.275063e-01	0.894
Signal attenuation	R-HSA-74749	1.275063e-01	0.894
Regulation of CDH11 function	R-HSA-9762292	1.275063e-01	0.894
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.368632e-01	0.864
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.368632e-01	0.864
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.368632e-01	0.864
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.368632e-01	0.864
CREB phosphorylation	R-HSA-199920	1.485451e-01	0.828
NRIF signals cell death from the nucleus	R-HSA-205043	1.295155e-01	0.888
cGMP effects	R-HSA-418457	1.295155e-01	0.888
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.516490e-01	0.819
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.516490e-01	0.819
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.465329e-01	0.834
Interleukin receptor SHC signaling	R-HSA-912526	1.402560e-01	0.853
Co-inhibition by CTLA4	R-HSA-389513	1.668392e-01	0.778
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.668392e-01	0.778
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.668392e-01	0.778
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.668392e-01	0.778
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.668392e-01	0.778
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.494127e-01	0.826
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.494127e-01	0.826
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.661147e-01	0.780
Activation of the pre-replicative complex	R-HSA-68962	1.661147e-01	0.780
Nuclear Receptor transcription pathway	R-HSA-383280	1.402704e-01	0.853
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.493980e-01	0.826
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.700095e-01	0.770
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.700095e-01	0.770
Centrosome maturation	R-HSA-380287	1.710687e-01	0.767
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.508612e-01	0.821
Cellular response to heat stress	R-HSA-3371556	1.486213e-01	0.828
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.644672e-01	0.784
Switching of origins to a post-replicative state	R-HSA-69052	1.493980e-01	0.826
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.416533e-01	0.849
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.416533e-01	0.849
Formation of the posterior neural plate	R-HSA-9832991	1.538768e-01	0.813
TCR signaling	R-HSA-202403	1.415879e-01	0.849
Platelet calcium homeostasis	R-HSA-418360	1.494127e-01	0.826
Activation of BH3-only proteins	R-HSA-114452	1.661147e-01	0.780
Activation of HOX genes during differentiation	R-HSA-5619507	1.418238e-01	0.848
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.418238e-01	0.848
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.503422e-01	0.823
Signaling by Nuclear Receptors	R-HSA-9006931	1.372494e-01	0.862
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.295155e-01	0.888
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	1.644672e-01	0.784
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.604900e-01	0.795
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.564091e-01	0.806
Regulation of KIT signaling	R-HSA-1433559	1.295155e-01	0.888
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.391570e-01	0.856
Interleukin-1 family signaling	R-HSA-446652	1.364039e-01	0.865
Deubiquitination	R-HSA-5688426	1.336573e-01	0.874
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.494127e-01	0.826
Regulation of PTEN gene transcription	R-HSA-8943724	1.356620e-01	0.868
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.683565e-01	0.774
Cell-extracellular matrix interactions	R-HSA-446353	1.516490e-01	0.819
Inflammasomes	R-HSA-622312	1.335728e-01	0.874
Signaling by Interleukins	R-HSA-449147	1.381707e-01	0.860
Formation of the anterior neural plate	R-HSA-9823739	1.516490e-01	0.819
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.717943e-01	0.765
Co-inhibition by PD-1	R-HSA-389948	1.739007e-01	0.760
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.739007e-01	0.760
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.740902e-01	0.759
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.752342e-01	0.756
Phase 4 - resting membrane potential	R-HSA-5576886	1.752342e-01	0.756
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.752342e-01	0.756
Negative regulation of FLT3	R-HSA-9706369	1.752342e-01	0.756
Transcriptional Regulation by VENTX	R-HSA-8853884	1.758082e-01	0.755
TICAM1 deficiency - HSE	R-HSA-5602566	2.550017e-01	0.593
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.550017e-01	0.593
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.550017e-01	0.593
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.550017e-01	0.593
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.550017e-01	0.593
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.550017e-01	0.593
Defective SLC26A4 causes Pendred syndrome (PDS)	R-HSA-5619046	2.550017e-01	0.593
TNFR1-mediated ceramide production	R-HSA-5626978	2.213192e-01	0.655
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.213192e-01	0.655
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.213192e-01	0.655
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.213192e-01	0.655
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.213192e-01	0.655
NFG and proNGF binds to p75NTR	R-HSA-205017	3.569763e-01	0.447
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	3.569763e-01	0.447
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	3.569763e-01	0.447
TRAF3 deficiency - HSE	R-HSA-5602571	3.569763e-01	0.447
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	3.569763e-01	0.447
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.569763e-01	0.447
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.569763e-01	0.447
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.569763e-01	0.447
Intestinal infectious diseases	R-HSA-8942233	3.569763e-01	0.447
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.569763e-01	0.447
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.569763e-01	0.447
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	3.569763e-01	0.447
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.569763e-01	0.447
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.569763e-01	0.447
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	3.569763e-01	0.447
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	3.569763e-01	0.447
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.569763e-01	0.447
MyD88 deficiency (TLR5)	R-HSA-5602680	3.569763e-01	0.447
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.569763e-01	0.447
Signaling by TCF7L2 mutants	R-HSA-5339700	3.569763e-01	0.447
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.569763e-01	0.447
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	1.840615e-01	0.735
TRIF-mediated programmed cell death	R-HSA-2562578	1.840615e-01	0.735
SOS-mediated signalling	R-HSA-112412	1.840615e-01	0.735
Cohesin Loading onto Chromatin	R-HSA-2470946	1.840615e-01	0.735
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.840615e-01	0.735
IRS activation	R-HSA-74713	2.753676e-01	0.560
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.753676e-01	0.560
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.215171e-01	0.655
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	2.215171e-01	0.655
Signaling by MRAS-complex mutants	R-HSA-9660537	2.215171e-01	0.655
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.215171e-01	0.655
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.820837e-01	0.740
p75NTR recruits signalling complexes	R-HSA-209543	2.118266e-01	0.674
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.603041e-01	0.585
Lipophagy	R-HSA-9613354	2.603041e-01	0.585
WNT mediated activation of DVL	R-HSA-201688	2.603041e-01	0.585
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	3.292128e-01	0.483
Phosphorylation of Emi1	R-HSA-176417	3.292128e-01	0.483
Noncanonical activation of NOTCH3	R-HSA-9017802	3.292128e-01	0.483
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.292128e-01	0.483
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.292128e-01	0.483
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.292128e-01	0.483
Signaling by MAPK mutants	R-HSA-9652817	3.292128e-01	0.483
Interaction between PHLDA1 and AURKA	R-HSA-8854521	4.449979e-01	0.352
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.449979e-01	0.352
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.449979e-01	0.352
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	4.449979e-01	0.352
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	R-HSA-5619049	4.449979e-01	0.352
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.449979e-01	0.352
TWIK related potassium channel (TREK)	R-HSA-1299503	4.449979e-01	0.352
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	4.449979e-01	0.352
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	4.449979e-01	0.352
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.449979e-01	0.352
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.449979e-01	0.352
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.001029e-01	0.699
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.001029e-01	0.699
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	2.427991e-01	0.615
Formation of axial mesoderm	R-HSA-9796292	2.427991e-01	0.615
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.882504e-01	0.725
Formation of apoptosome	R-HSA-111458	2.998642e-01	0.523
Regulation of the apoptosome activity	R-HSA-9627069	2.998642e-01	0.523
MET activates RAP1 and RAC1	R-HSA-8875555	2.998642e-01	0.523
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.260760e-01	0.646
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.746977e-01	0.561
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.746977e-01	0.561
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.818985e-01	0.418
Signaling by LTK in cancer	R-HSA-9842640	3.818985e-01	0.418
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.818985e-01	0.418
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.818985e-01	0.418
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.529687e-01	0.597
Ephrin signaling	R-HSA-3928664	2.529687e-01	0.597
ChREBP activates metabolic gene expression	R-HSA-163765	3.396974e-01	0.469
PECAM1 interactions	R-HSA-210990	3.396974e-01	0.469
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.396974e-01	0.469
Activated NTRK3 signals through RAS	R-HSA-9034864	3.396974e-01	0.469
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.170335e-01	0.663
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.170335e-01	0.663
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.170335e-01	0.663
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.072290e-01	0.513
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.072290e-01	0.513
E2F mediated regulation of DNA replication	R-HSA-113510	2.805938e-01	0.552
HIV elongation arrest and recovery	R-HSA-167287	2.382528e-01	0.623
Pausing and recovery of HIV elongation	R-HSA-167290	2.382528e-01	0.623
mRNA Splicing - Minor Pathway	R-HSA-72165	1.786081e-01	0.748
Orc1 removal from chromatin	R-HSA-68949	1.804994e-01	0.744
Downstream signaling of activated FGFR3	R-HSA-5654708	2.601059e-01	0.585
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.601059e-01	0.585
Deadenylation of mRNA	R-HSA-429947	2.825849e-01	0.549
TRAF6 mediated NF-kB activation	R-HSA-933542	2.825849e-01	0.549
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.087663e-01	0.510
Phosphorylation of the APC/C	R-HSA-176412	3.401155e-01	0.468
Cytochrome c-mediated apoptotic response	R-HSA-111461	3.793663e-01	0.421
Activated NTRK2 signals through RAS	R-HSA-9026519	3.793663e-01	0.421
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	3.793663e-01	0.421
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.793663e-01	0.421
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	4.327335e-01	0.364
MET activates PI3K/AKT signaling	R-HSA-8851907	4.327335e-01	0.364
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.327335e-01	0.364
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	4.327335e-01	0.364
Disinhibition of SNARE formation	R-HSA-114516	4.327335e-01	0.364
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	4.327335e-01	0.364
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	5.209748e-01	0.283
Axonal growth stimulation	R-HSA-209563	5.209748e-01	0.283
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	5.209748e-01	0.283
MET activates PTPN11	R-HSA-8865999	5.209748e-01	0.283
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.209748e-01	0.283
Invadopodia formation	R-HSA-8941237	5.209748e-01	0.283
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.209748e-01	0.283
Defective GCLC causes HAGGSD	R-HSA-5578999	5.209748e-01	0.283
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	5.209748e-01	0.283
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.209748e-01	0.283
Classical Kir channels	R-HSA-1296053	5.209748e-01	0.283
GPER1 signaling	R-HSA-9634597	2.085115e-01	0.681
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.412518e-01	0.618
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.605824e-01	0.584
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.605824e-01	0.584
Downstream signaling of activated FGFR4	R-HSA-5654716	2.824983e-01	0.549
DAP12 signaling	R-HSA-2424491	2.824983e-01	0.549
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.824983e-01	0.549
Tight junction interactions	R-HSA-420029	3.077098e-01	0.512
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.077098e-01	0.512
HIV Transcription Elongation	R-HSA-167169	2.599937e-01	0.585
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.599937e-01	0.585
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.599937e-01	0.585
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.730991e-01	0.428
RUNX3 regulates p14-ARF	R-HSA-8951936	4.184959e-01	0.378
Leading Strand Synthesis	R-HSA-69109	4.184959e-01	0.378
Polymerase switching	R-HSA-69091	4.184959e-01	0.378
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.184959e-01	0.378
Activation of NF-kappaB in B cells	R-HSA-1169091	2.569318e-01	0.590
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.500088e-01	0.602
Interaction between L1 and Ankyrins	R-HSA-445095	3.589144e-01	0.445
PI3K events in ERBB2 signaling	R-HSA-1963642	4.059443e-01	0.392
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	4.059443e-01	0.392
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.059443e-01	0.392
Regulation by c-FLIP	R-HSA-3371378	4.812375e-01	0.318
Dimerization of procaspase-8	R-HSA-69416	4.812375e-01	0.318
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.812375e-01	0.318
Activation of RAS in B cells	R-HSA-1169092	4.812375e-01	0.318
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	3.948031e-01	0.404
Notch-HLH transcription pathway	R-HSA-350054	3.948031e-01	0.404
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.392417e-01	0.621
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.567725e-01	0.340
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.421130e-01	0.616
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.421130e-01	0.616
Formation of a pool of free 40S subunits	R-HSA-72689	3.034873e-01	0.518
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.795700e-01	0.421
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.795700e-01	0.421
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.889435e-01	0.539
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.889435e-01	0.539
Downstream signaling of activated FGFR1	R-HSA-5654687	4.228550e-01	0.374
Downstream signaling of activated FGFR2	R-HSA-5654696	4.228550e-01	0.374
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.518269e-01	0.345
PI-3K cascade:FGFR3	R-HSA-5654710	4.703977e-01	0.328
IKK complex recruitment mediated by RIP1	R-HSA-937041	4.703977e-01	0.328
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.703977e-01	0.328
Removal of the Flap Intermediate	R-HSA-69166	4.939396e-01	0.306
CASP8 activity is inhibited	R-HSA-5218900	5.270963e-01	0.278
ALK mutants bind TKIs	R-HSA-9700645	5.270963e-01	0.278
snRNP Assembly	R-HSA-191859	3.995261e-01	0.398
Metabolism of non-coding RNA	R-HSA-194441	3.995261e-01	0.398
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.653573e-01	0.437
Degradation of GLI1 by the proteasome	R-HSA-5610780	4.328447e-01	0.364
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.328447e-01	0.364
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.328447e-01	0.364
EGFR downregulation	R-HSA-182971	4.618177e-01	0.336
ATP-dependent chromatin remodelers	R-HSA-9932444	4.798196e-01	0.319
SWI/SNF chromatin remodelers	R-HSA-9932451	4.798196e-01	0.319
TGFBR3 expression	R-HSA-9839394	4.798196e-01	0.319
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.029339e-01	0.395
PI-3K cascade:FGFR4	R-HSA-5654720	5.016575e-01	0.300
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	5.016575e-01	0.300
Transcription of the HIV genome	R-HSA-167172	4.429178e-01	0.354
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	4.870265e-01	0.312
Erythropoietin activates RAS	R-HSA-9027284	5.297935e-01	0.276
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.297935e-01	0.276
SHC1 events in EGFR signaling	R-HSA-180336	5.297935e-01	0.276
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.297935e-01	0.276
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	5.073106e-01	0.295
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.589015e-01	0.338
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.978355e-01	0.303
Transport of the SLBP independent Mature mRNA	R-HSA-159227	5.118463e-01	0.291
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	4.784261e-01	0.320
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.156823e-01	0.288
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.156823e-01	0.288
Signaling by EGFR	R-HSA-177929	3.445925e-01	0.463
Signaling by EGFR in Cancer	R-HSA-1643713	3.331946e-01	0.477
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.882504e-01	0.725
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.882504e-01	0.725
Eukaryotic Translation Initiation	R-HSA-72613	3.640773e-01	0.439
Cap-dependent Translation Initiation	R-HSA-72737	3.640773e-01	0.439
Specification of the neural plate border	R-HSA-9834899	2.805938e-01	0.552
G-protein beta:gamma signalling	R-HSA-397795	3.519527e-01	0.454
Regulation of mitotic cell cycle	R-HSA-453276	1.948333e-01	0.710
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.948333e-01	0.710
Formation of definitive endoderm	R-HSA-9823730	3.087663e-01	0.510
FOXO-mediated transcription	R-HSA-9614085	3.581901e-01	0.446
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.236036e-01	0.490
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.421130e-01	0.616
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	3.795700e-01	0.421
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	2.998642e-01	0.523
VxPx cargo-targeting to cilium	R-HSA-5620916	5.016575e-01	0.300
Circadian clock	R-HSA-9909396	5.101333e-01	0.292
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	1.840615e-01	0.735
Transcriptional regulation of testis differentiation	R-HSA-9690406	3.730991e-01	0.428
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	2.957384e-01	0.529
MHC class II antigen presentation	R-HSA-2132295	3.698678e-01	0.432
Cyclin D associated events in G1	R-HSA-69231	2.411319e-01	0.618
G1 Phase	R-HSA-69236	2.411319e-01	0.618
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.945519e-01	0.531
p75NTR regulates axonogenesis	R-HSA-193697	5.270963e-01	0.278
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	3.793663e-01	0.421
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.730991e-01	0.428
Fanconi Anemia Pathway	R-HSA-6783310	5.190379e-01	0.285
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	2.746977e-01	0.561
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.096651e-01	0.388
Processive synthesis on the lagging strand	R-HSA-69183	5.297935e-01	0.276
Synthesis of DNA	R-HSA-69239	3.922110e-01	0.406
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	3.034873e-01	0.518
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	1.951197e-01	0.710
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	5.083208e-01	0.294
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.603041e-01	0.585
EGFR Transactivation by Gastrin	R-HSA-2179392	2.998642e-01	0.523
Glucagon signaling in metabolic regulation	R-HSA-163359	2.404415e-01	0.619
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.812375e-01	0.318
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	4.567725e-01	0.340
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.384394e-01	0.358
Downstream TCR signaling	R-HSA-202424	4.899936e-01	0.310
Signaling by FGFR4	R-HSA-5654743	2.240139e-01	0.650
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.825856e-01	0.739
IGF1R signaling cascade	R-HSA-2428924	1.823538e-01	0.739
Apoptotic factor-mediated response	R-HSA-111471	4.384394e-01	0.358
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.018960e-01	0.695
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.077098e-01	0.512
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.213192e-01	0.655
PI3K/AKT activation	R-HSA-198203	2.998642e-01	0.523
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.260760e-01	0.646
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.396974e-01	0.469
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.230069e-01	0.652
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.059443e-01	0.392
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	5.270963e-01	0.278
Peptide chain elongation	R-HSA-156902	3.579889e-01	0.446
Deadenylation-dependent mRNA decay	R-HSA-429914	3.995261e-01	0.398
DNA strand elongation	R-HSA-69190	4.870265e-01	0.312
Stabilization of p53	R-HSA-69541	5.156823e-01	0.288
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.296498e-01	0.276
Interleukin-1 signaling	R-HSA-9020702	2.223860e-01	0.653
Extra-nuclear estrogen signaling	R-HSA-9009391	2.223860e-01	0.653
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.152565e-01	0.501
Signaling by FGFR1	R-HSA-5654736	4.677787e-01	0.330
Signaling by FGFR3	R-HSA-5654741	2.587016e-01	0.587
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.448530e-01	0.462
Myogenesis	R-HSA-525793	1.965396e-01	0.707
Downregulation of ERBB2 signaling	R-HSA-8863795	2.824983e-01	0.549
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.548222e-01	0.342
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.118266e-01	0.674
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.805938e-01	0.552
TNF signaling	R-HSA-75893	2.391334e-01	0.621
Resolution of D-Loop Structures	R-HSA-5693537	2.404415e-01	0.619
Generation of second messenger molecules	R-HSA-202433	2.599937e-01	0.585
Hedgehog 'on' state	R-HSA-5632684	2.794327e-01	0.554
Regulation of TNFR1 signaling	R-HSA-5357905	2.766761e-01	0.558
Dopamine receptors	R-HSA-390651	2.213192e-01	0.655
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.213192e-01	0.655
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.753676e-01	0.560
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.215171e-01	0.655
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	2.603041e-01	0.585
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.208560e-01	0.656
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.184959e-01	0.378
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.812375e-01	0.318
Regulation of CDH1 Function	R-HSA-9764561	3.627943e-01	0.440
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	4.463997e-01	0.350
IRS-related events triggered by IGF1R	R-HSA-2428928	4.364174e-01	0.360
Telomere C-strand synthesis initiation	R-HSA-174430	5.297935e-01	0.276
Signaling by Hedgehog	R-HSA-5358351	2.147556e-01	0.668
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.339279e-01	0.631
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.331946e-01	0.477
Integration of energy metabolism	R-HSA-163685	2.570947e-01	0.590
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.017319e-01	0.396
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.818985e-01	0.418
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	2.404415e-01	0.619
Repression of WNT target genes	R-HSA-4641265	4.184959e-01	0.378
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	4.105813e-01	0.387
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	5.297935e-01	0.276
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	5.297935e-01	0.276
Clathrin-mediated endocytosis	R-HSA-8856828	5.025914e-01	0.299
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.965396e-01	0.707
MyD88-independent TLR4 cascade	R-HSA-166166	1.970675e-01	0.705
Ca2+ pathway	R-HSA-4086398	5.296498e-01	0.276
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.606197e-01	0.584
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.339169e-01	0.476
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.970675e-01	0.705
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.918194e-01	0.308
PTEN Regulation	R-HSA-6807070	3.618176e-01	0.442
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.812061e-01	0.551
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.318030e-01	0.479
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.074572e-01	0.683
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.606197e-01	0.584
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.606197e-01	0.584
Signaling by WNT in cancer	R-HSA-4791275	2.018960e-01	0.695
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.918194e-01	0.308
Sensory perception of sour taste	R-HSA-9729555	2.213192e-01	0.655
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.292128e-01	0.483
Abacavir transmembrane transport	R-HSA-2161517	3.818985e-01	0.418
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	3.793663e-01	0.421
Reduction of cytosolic Ca++ levels	R-HSA-418359	3.793663e-01	0.421
Ca2+ activated K+ channels	R-HSA-1296052	4.327335e-01	0.364
TGFBR3 PTM regulation	R-HSA-9839383	4.812375e-01	0.318
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.812375e-01	0.318
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.812375e-01	0.318
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.519527e-01	0.454
Eukaryotic Translation Elongation	R-HSA-156842	3.367377e-01	0.473
Defects in biotin (Btn) metabolism	R-HSA-3323169	5.270963e-01	0.278
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.798196e-01	0.319
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.189303e-01	0.496
Signaling by FGFR in disease	R-HSA-1226099	4.318949e-01	0.365
FGFR1 mutant receptor activation	R-HSA-1839124	2.208560e-01	0.656
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.825849e-01	0.549
Interleukin-2 signaling	R-HSA-9020558	3.396974e-01	0.469
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.184959e-01	0.378
Adaptive Immune System	R-HSA-1280218	4.800447e-01	0.319
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.385283e-01	0.470
Autophagy	R-HSA-9612973	4.174579e-01	0.379
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.844275e-01	0.415
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.396974e-01	0.469
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.327335e-01	0.364
Degradation of CDH1	R-HSA-9766229	2.242113e-01	0.649
Lysosphingolipid and LPA receptors	R-HSA-419408	5.297935e-01	0.276
Eukaryotic Translation Termination	R-HSA-72764	4.934156e-01	0.307
Neuronal System	R-HSA-112316	3.745442e-01	0.426
RMTs methylate histone arginines	R-HSA-3214858	3.590944e-01	0.445
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.950067e-01	0.530
Mismatch Repair	R-HSA-5358508	4.384394e-01	0.358
Platelet homeostasis	R-HSA-418346	3.785101e-01	0.422
Regulation of insulin secretion	R-HSA-422356	2.606197e-01	0.584
Developmental Biology	R-HSA-1266738	3.090442e-01	0.510
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.793663e-01	0.421
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.109134e-01	0.386
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.429178e-01	0.354
Signaling by TGFB family members	R-HSA-9006936	4.635881e-01	0.334
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.105813e-01	0.387
MAP kinase activation	R-HSA-450294	4.364174e-01	0.360
Regulation of RUNX2 expression and activity	R-HSA-8939902	4.364174e-01	0.360
Spry regulation of FGF signaling	R-HSA-1295596	5.297935e-01	0.276
Interleukin-2 family signaling	R-HSA-451927	2.599937e-01	0.585
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	4.518269e-01	0.345
Nuclear Envelope Breakdown	R-HSA-2980766	2.548316e-01	0.594
Platelet activation, signaling and aggregation	R-HSA-76002	4.158959e-01	0.381
Amyloid fiber formation	R-HSA-977225	2.447263e-01	0.611
Pre-NOTCH Expression and Processing	R-HSA-1912422	4.750216e-01	0.323
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.569763e-01	0.447
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.569763e-01	0.447
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.569763e-01	0.447
Regulation of PTEN localization	R-HSA-8948747	1.840615e-01	0.735
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.215171e-01	0.655
Unwinding of DNA	R-HSA-176974	2.603041e-01	0.585
CDC6 association with the ORC:origin complex	R-HSA-68689	3.292128e-01	0.483
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	4.449979e-01	0.352
Membrane binding and targetting of GAG proteins	R-HSA-174490	2.427991e-01	0.615
Signaling by PDGFR in disease	R-HSA-9671555	2.106535e-01	0.676
Activation of BIM and translocation to mitochondria	R-HSA-111446	5.209748e-01	0.283
MET interacts with TNS proteins	R-HSA-8875513	5.209748e-01	0.283
Downstream signal transduction	R-HSA-186763	3.053342e-01	0.515
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.384394e-01	0.358
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	5.270963e-01	0.278
Budding and maturation of HIV virion	R-HSA-162588	4.618177e-01	0.336
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.798196e-01	0.319
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.630335e-01	0.440
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.731486e-01	0.325
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.731486e-01	0.325
Signaling by PTK6	R-HSA-8848021	4.731486e-01	0.325
FLT3 signaling in disease	R-HSA-9682385	4.463997e-01	0.350
Aquaporin-mediated transport	R-HSA-445717	3.208018e-01	0.494
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	4.001246e-01	0.398
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	4.001246e-01	0.398
MAPK6/MAPK4 signaling	R-HSA-5687128	5.023115e-01	0.299
Oncogene Induced Senescence	R-HSA-2559585	2.812061e-01	0.551
Signaling by FGFR4 in disease	R-HSA-5655291	2.746977e-01	0.561
Signaling by ERBB4	R-HSA-1236394	3.254694e-01	0.487
Sensory processing of sound	R-HSA-9659379	5.154864e-01	0.288
Pyroptosis	R-HSA-5620971	3.847483e-01	0.415
Regulation of NF-kappa B signaling	R-HSA-9758274	3.401155e-01	0.468
Signaling by NTRKs	R-HSA-166520	2.596586e-01	0.586
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	3.717584e-01	0.430
Platelet sensitization by LDL	R-HSA-432142	4.384394e-01	0.358
Protein ubiquitination	R-HSA-8852135	3.412118e-01	0.467
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.106535e-01	0.676
Signaling by KIT in disease	R-HSA-9669938	3.948031e-01	0.404
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.546828e-01	0.342
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.823538e-01	0.739
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	2.753676e-01	0.560
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.292128e-01	0.483
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	2.746977e-01	0.561
Nef and signal transduction	R-HSA-164944	3.818985e-01	0.418
Syndecan interactions	R-HSA-3000170	2.579478e-01	0.588
CHL1 interactions	R-HSA-447041	4.327335e-01	0.364
Protein hydroxylation	R-HSA-9629569	5.016575e-01	0.300
Heme signaling	R-HSA-9707616	4.548222e-01	0.342
Signaling by NOTCH	R-HSA-157118	4.104998e-01	0.387
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.645762e-01	0.577
Displacement of DNA glycosylase by APEX1	R-HSA-110357	1.840615e-01	0.735
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.804994e-01	0.744
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.136438e-01	0.504
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	5.253860e-01	0.280
Transcriptional regulation by RUNX2	R-HSA-8878166	4.918194e-01	0.308
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.660390e-01	0.436
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	5.297935e-01	0.276
Tie2 Signaling	R-HSA-210993	4.384394e-01	0.358
MITF-M-regulated melanocyte development	R-HSA-9730414	2.839670e-01	0.547
Interleukin-15 signaling	R-HSA-8983432	4.184959e-01	0.378
Ion transport by P-type ATPases	R-HSA-936837	2.677661e-01	0.572
Interleukin-6 signaling	R-HSA-1059683	4.567725e-01	0.340
DSCAM interactions	R-HSA-376172	4.449979e-01	0.352
Diseases of cellular response to stress	R-HSA-9675132	4.449979e-01	0.352
Diseases of Cellular Senescence	R-HSA-9630747	4.449979e-01	0.352
Tandem pore domain potassium channels	R-HSA-1296346	2.998642e-01	0.523
Synthesis of PI	R-HSA-1483226	3.396974e-01	0.469
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.209748e-01	0.283
Signaling by ALK	R-HSA-201556	2.412518e-01	0.618
Alpha-defensins	R-HSA-1462054	4.812375e-01	0.318
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.297935e-01	0.276
Diseases of DNA repair	R-HSA-9675135	4.001246e-01	0.398
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.519527e-01	0.454
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.965396e-01	0.707
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.220424e-01	0.282
Zygotic genome activation (ZGA)	R-HSA-9819196	3.373056e-01	0.472
Histamine receptors	R-HSA-390650	5.209748e-01	0.283
Interleukin-7 signaling	R-HSA-1266695	4.798196e-01	0.319
Sodium-coupled phosphate cotransporters	R-HSA-427652	3.292128e-01	0.483
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.449979e-01	0.352
MECP2 regulates transcription factors	R-HSA-9022707	4.327335e-01	0.364
Regulation of beta-cell development	R-HSA-186712	5.247780e-01	0.280
Regulation of CDH11 gene transcription	R-HSA-9762293	2.603041e-01	0.585
STING mediated induction of host immune responses	R-HSA-1834941	4.703977e-01	0.328
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.072290e-01	0.513
FasL/ CD95L signaling	R-HSA-75157	5.209748e-01	0.283
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.833341e-01	0.548
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	4.384394e-01	0.358
Unfolded Protein Response (UPR)	R-HSA-381119	5.247792e-01	0.280
Interleukin-12 signaling	R-HSA-9020591	4.655736e-01	0.332
Gene Silencing by RNA	R-HSA-211000	4.855357e-01	0.314
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	5.315592e-01	0.274
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	5.315592e-01	0.274
Signaling by FGFR2	R-HSA-5654738	5.318548e-01	0.274
SHC-mediated cascade:FGFR3	R-HSA-5654704	5.320810e-01	0.274
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.339377e-01	0.273
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.341998e-01	0.272
RNA Polymerase I Transcription Termination	R-HSA-73863	5.341998e-01	0.272
Signaling by FGFR3 in disease	R-HSA-5655332	5.341998e-01	0.272
Cristae formation	R-HSA-8949613	5.341998e-01	0.272
Striated Muscle Contraction	R-HSA-390522	5.362005e-01	0.271
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.362005e-01	0.271
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.362005e-01	0.271
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.381039e-01	0.269
Attenuation phase	R-HSA-3371568	5.381039e-01	0.269
Glycogen metabolism	R-HSA-8982491	5.381039e-01	0.269
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	5.399231e-01	0.268
Signaling by TGFBR3	R-HSA-9839373	5.399231e-01	0.268
Regulation of PTEN stability and activity	R-HSA-8948751	5.416680e-01	0.266
RAB geranylgeranylation	R-HSA-8873719	5.433466e-01	0.265
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	5.475786e-01	0.262
Interleukin-12 family signaling	R-HSA-447115	5.495189e-01	0.260
NPAS4 regulates expression of target genes	R-HSA-9768919	5.600211e-01	0.252
NOD1/2 Signaling Pathway	R-HSA-168638	5.600211e-01	0.252
Telomere Extension By Telomerase	R-HSA-171319	5.604008e-01	0.252
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.604008e-01	0.252
Formation of the Early Elongation Complex	R-HSA-113418	5.604008e-01	0.252
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.604008e-01	0.252
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.609817e-01	0.251
SHC-mediated cascade:FGFR4	R-HSA-5654719	5.615540e-01	0.251
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.615540e-01	0.251
Assembly Of The HIV Virion	R-HSA-175474	5.615540e-01	0.251
Regulated Necrosis	R-HSA-5218859	5.623880e-01	0.250
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	5.641786e-01	0.249
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.641786e-01	0.249
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.641786e-01	0.249
Glycolysis	R-HSA-70171	5.667253e-01	0.247
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.701251e-01	0.244
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	5.701251e-01	0.244
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	5.701251e-01	0.244
Apoptosis induced DNA fragmentation	R-HSA-140342	5.701251e-01	0.244
Receptor Mediated Mitophagy	R-HSA-8934903	5.701251e-01	0.244
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.701251e-01	0.244
Signaling by Leptin	R-HSA-2586552	5.701251e-01	0.244
Cilium Assembly	R-HSA-5617833	5.794421e-01	0.237
Selenocysteine synthesis	R-HSA-2408557	5.809363e-01	0.236
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	5.814285e-01	0.236
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	5.832488e-01	0.234
Metabolism of RNA	R-HSA-8953854	5.848985e-01	0.233
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	5.858399e-01	0.232
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.858399e-01	0.232
HCN channels	R-HSA-1296061	5.865546e-01	0.232
NADE modulates death signalling	R-HSA-205025	5.865546e-01	0.232
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	5.865546e-01	0.232
ATP sensitive Potassium channels	R-HSA-1296025	5.865546e-01	0.232
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.865546e-01	0.232
Defective CP causes aceruloplasminemia (ACERULOP)	R-HSA-5619060	5.865546e-01	0.232
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.865546e-01	0.232
Regulation of gap junction activity	R-HSA-191650	5.865546e-01	0.232
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.865546e-01	0.232
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	5.865546e-01	0.232
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.865546e-01	0.232
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.865546e-01	0.232
FLT3 signaling through SRC family kinases	R-HSA-9706374	5.865546e-01	0.232
PI-3K cascade:FGFR1	R-HSA-5654689	5.899841e-01	0.229
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	5.899841e-01	0.229
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	5.949598e-01	0.226
Interleukin-17 signaling	R-HSA-448424	5.963986e-01	0.224
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.969812e-01	0.224
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.969812e-01	0.224
Phase 2 - plateau phase	R-HSA-5576893	5.969812e-01	0.224
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.969812e-01	0.224
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.969812e-01	0.224
Acetylcholine regulates insulin secretion	R-HSA-399997	5.969812e-01	0.224
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.969812e-01	0.224
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	5.969812e-01	0.224
Disorders of Developmental Biology	R-HSA-9675151	5.969812e-01	0.224
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.969812e-01	0.224
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.972937e-01	0.224
C-type lectin receptors (CLRs)	R-HSA-5621481	5.985206e-01	0.223
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.025803e-01	0.220
RNA Polymerase I Transcription Initiation	R-HSA-73762	6.025803e-01	0.220
Vif-mediated degradation of APOBEC3G	R-HSA-180585	6.058322e-01	0.218
Triglyceride catabolism	R-HSA-163560	6.058322e-01	0.218
GPVI-mediated activation cascade	R-HSA-114604	6.058322e-01	0.218
Cellular response to chemical stress	R-HSA-9711123	6.062195e-01	0.217
Viral mRNA Translation	R-HSA-192823	6.087819e-01	0.216
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	6.102394e-01	0.214
Presynaptic depolarization and calcium channel opening	R-HSA-112308	6.102394e-01	0.214
Ionotropic activity of kainate receptors	R-HSA-451306	6.102394e-01	0.214
Bicarbonate transporters	R-HSA-425381	6.102394e-01	0.214
RHOBTB3 ATPase cycle	R-HSA-9706019	6.102394e-01	0.214
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	6.104563e-01	0.214
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.104563e-01	0.214
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.129394e-01	0.213
Insulin receptor signalling cascade	R-HSA-74751	6.145962e-01	0.211
IRS-mediated signalling	R-HSA-112399	6.167144e-01	0.210
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	6.172992e-01	0.210
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	6.172992e-01	0.210
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.172992e-01	0.210
Regulation of RAS by GAPs	R-HSA-5658442	6.194419e-01	0.208
PI3K Cascade	R-HSA-109704	6.194419e-01	0.208
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.223894e-01	0.206
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.272074e-01	0.203
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	6.277285e-01	0.202
Ovarian tumor domain proteases	R-HSA-5689896	6.277285e-01	0.202
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.281251e-01	0.202
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.281251e-01	0.202
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.281251e-01	0.202
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.291424e-01	0.201
L1CAM interactions	R-HSA-373760	6.337820e-01	0.198
DAP12 interactions	R-HSA-2172127	6.428229e-01	0.192
Amine ligand-binding receptors	R-HSA-375280	6.428229e-01	0.192
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.431597e-01	0.192
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.431597e-01	0.192
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	6.431597e-01	0.192
NOSIP mediated eNOS trafficking	R-HSA-203754	6.431597e-01	0.192
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	6.431597e-01	0.192
FLT3 signaling by CBL mutants	R-HSA-9706377	6.431597e-01	0.192
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.431597e-01	0.192
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.431597e-01	0.192
Defective F9 activation	R-HSA-9673221	6.431597e-01	0.192
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	6.431597e-01	0.192
Post-transcriptional silencing by small RNAs	R-HSA-426496	6.431597e-01	0.192
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.431597e-01	0.192
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	6.431597e-01	0.192
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.434461e-01	0.191
Complex III assembly	R-HSA-9865881	6.434461e-01	0.191
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.434461e-01	0.191
Glucose metabolism	R-HSA-70326	6.462448e-01	0.190
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	6.474306e-01	0.189
Condensation of Prometaphase Chromosomes	R-HSA-2514853	6.474306e-01	0.189
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	6.474306e-01	0.189
ERKs are inactivated	R-HSA-202670	6.474306e-01	0.189
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.474306e-01	0.189
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	6.474306e-01	0.189
Sodium/Calcium exchangers	R-HSA-425561	6.474306e-01	0.189
Gastrulation	R-HSA-9758941	6.531355e-01	0.185
Late Phase of HIV Life Cycle	R-HSA-162599	6.539514e-01	0.184
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.563154e-01	0.183
Inwardly rectifying K+ channels	R-HSA-1296065	6.570355e-01	0.182
Transmission across Chemical Synapses	R-HSA-112315	6.574154e-01	0.182
GAB1 signalosome	R-HSA-180292	6.575660e-01	0.182
Nephron development	R-HSA-9831926	6.575660e-01	0.182
Vesicle-mediated transport	R-HSA-5653656	6.582612e-01	0.182
SARS-CoV-1-host interactions	R-HSA-9692914	6.618084e-01	0.179
Asymmetric localization of PCP proteins	R-HSA-4608870	6.620260e-01	0.179
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	6.620260e-01	0.179
PI-3K cascade:FGFR2	R-HSA-5654695	6.683882e-01	0.175
Formation of the nephric duct	R-HSA-9830364	6.683882e-01	0.175
Selective autophagy	R-HSA-9663891	6.688266e-01	0.175
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.693256e-01	0.174
Cytokine Signaling in Immune system	R-HSA-1280215	6.745397e-01	0.171
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.755525e-01	0.170
ISG15 antiviral mechanism	R-HSA-1169408	6.755525e-01	0.170
Ribosome-associated quality control	R-HSA-9948299	6.771735e-01	0.169
Nuclear RNA decay	R-HSA-9930044	6.789325e-01	0.168
Regulation of necroptotic cell death	R-HSA-5675482	6.789325e-01	0.168
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.789325e-01	0.168
Cardiogenesis	R-HSA-9733709	6.789325e-01	0.168
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	6.789325e-01	0.168
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.817472e-01	0.166
IRAK1 recruits IKK complex	R-HSA-937039	6.817472e-01	0.166
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.817472e-01	0.166
GRB2 events in EGFR signaling	R-HSA-179812	6.817472e-01	0.166
MET activates RAS signaling	R-HSA-8851805	6.817472e-01	0.166
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.817472e-01	0.166
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	6.817472e-01	0.166
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.817472e-01	0.166
Disorders of Nervous System Development	R-HSA-9697154	6.817472e-01	0.166
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.817472e-01	0.166
Pervasive developmental disorders	R-HSA-9005895	6.817472e-01	0.166
OAS antiviral response	R-HSA-8983711	6.817472e-01	0.166
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	6.817472e-01	0.166
Regulation of signaling by CBL	R-HSA-912631	6.852870e-01	0.164
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.852870e-01	0.164
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.852870e-01	0.164
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.889772e-01	0.162
Aggrephagy	R-HSA-9646399	6.889772e-01	0.162
Diseases of Immune System	R-HSA-5260271	6.889772e-01	0.162
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.889772e-01	0.162
Nuclear signaling by ERBB4	R-HSA-1251985	6.889772e-01	0.162
Translation initiation complex formation	R-HSA-72649	6.910054e-01	0.161
PDE3B signalling	R-HSA-165160	6.920177e-01	0.160
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.920177e-01	0.160
PKB-mediated events	R-HSA-109703	6.920177e-01	0.160
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.920177e-01	0.160
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.920177e-01	0.160
Signaling by RNF43 mutants	R-HSA-5340588	6.920177e-01	0.160
Ligand-receptor interactions	R-HSA-5632681	6.920177e-01	0.160
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.920177e-01	0.160
Pentose phosphate pathway disease	R-HSA-6791465	6.920177e-01	0.160
Synthesis of PS	R-HSA-1483101	6.920177e-01	0.160
Ceramide signalling	R-HSA-193681	6.920177e-01	0.160
Formation of the Editosome	R-HSA-75094	6.920177e-01	0.160
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.920177e-01	0.160
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.920177e-01	0.160
Signalling to p38 via RIT and RIN	R-HSA-187706	6.920177e-01	0.160
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.920177e-01	0.160
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.920177e-01	0.160
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.920177e-01	0.160
TRAIL signaling	R-HSA-75158	6.920177e-01	0.160
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	6.921041e-01	0.160
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	6.921041e-01	0.160
Metalloprotease DUBs	R-HSA-5689901	6.921041e-01	0.160
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.984898e-01	0.156
Vpu mediated degradation of CD4	R-HSA-180534	6.998735e-01	0.155
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.998735e-01	0.155
Potassium Channels	R-HSA-1296071	7.052786e-01	0.152
HCMV Early Events	R-HSA-9609690	7.062454e-01	0.151
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.074929e-01	0.150
Signaling by NOTCH3	R-HSA-9012852	7.074929e-01	0.150
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	7.078425e-01	0.150
Resolution of Abasic Sites (AP sites)	R-HSA-73933	7.078425e-01	0.150
Macroautophagy	R-HSA-1632852	7.091039e-01	0.149
Signaling by NODAL	R-HSA-1181150	7.112937e-01	0.148
Negative regulation of MET activity	R-HSA-6807004	7.112937e-01	0.148
Creatine metabolism	R-HSA-71288	7.112937e-01	0.148
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	7.132790e-01	0.147
CD28 dependent Vav1 pathway	R-HSA-389359	7.132790e-01	0.147
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	7.132790e-01	0.147
Frs2-mediated activation	R-HSA-170968	7.132790e-01	0.147
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.132790e-01	0.147
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.132790e-01	0.147
Maturation of nucleoprotein	R-HSA-9683610	7.132790e-01	0.147
Replication of the SARS-CoV-1 genome	R-HSA-9682706	7.132790e-01	0.147
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.145859e-01	0.146
EPHA-mediated growth cone collapse	R-HSA-3928663	7.145859e-01	0.146
SHC-mediated cascade:FGFR2	R-HSA-5654699	7.145859e-01	0.146
Insulin processing	R-HSA-264876	7.145859e-01	0.146
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.198488e-01	0.143
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.198488e-01	0.143
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.198488e-01	0.143
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.198488e-01	0.143
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.233952e-01	0.141
Ribosomal scanning and start codon recognition	R-HSA-72702	7.233952e-01	0.141
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.233952e-01	0.141
Toll-like Receptor Cascades	R-HSA-168898	7.252635e-01	0.140
Degradation of CRY and PER proteins	R-HSA-9932298	7.259127e-01	0.139
Beta-catenin independent WNT signaling	R-HSA-3858494	7.318407e-01	0.136
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	7.322780e-01	0.135
STAT5 Activation	R-HSA-9645135	7.341886e-01	0.134
Erythropoietin activates STAT5	R-HSA-9027283	7.341886e-01	0.134
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	7.341886e-01	0.134
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	7.341886e-01	0.134
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	7.341886e-01	0.134
Hydrolysis of LPE	R-HSA-1483152	7.341886e-01	0.134
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.341886e-01	0.134
Neurofascin interactions	R-HSA-447043	7.341886e-01	0.134
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	7.341886e-01	0.134
NADPH regeneration	R-HSA-389542	7.341886e-01	0.134
Lipid particle organization	R-HSA-8964572	7.341886e-01	0.134
HIV Infection	R-HSA-162906	7.350244e-01	0.134
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	7.356106e-01	0.133
Lagging Strand Synthesis	R-HSA-69186	7.356106e-01	0.133
ERK/MAPK targets	R-HSA-198753	7.356106e-01	0.133
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.356106e-01	0.133
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.356106e-01	0.133
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.388563e-01	0.131
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	7.421452e-01	0.130
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	7.421452e-01	0.130
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	7.421452e-01	0.130
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.421452e-01	0.130
CRMPs in Sema3A signaling	R-HSA-399956	7.421452e-01	0.130
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	7.421452e-01	0.130
Adipogenesis	R-HSA-9843745	7.446928e-01	0.128
Signaling by MET	R-HSA-6806834	7.448430e-01	0.128
Signaling by FGFR2 in disease	R-HSA-5655253	7.481526e-01	0.126
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	7.534235e-01	0.123
Termination of translesion DNA synthesis	R-HSA-5656169	7.558710e-01	0.122
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.582774e-01	0.120
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.582774e-01	0.120
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.582774e-01	0.120
Extension of Telomeres	R-HSA-180786	7.675464e-01	0.115
Activation of BAD and translocation to mitochondria	R-HSA-111447	7.684845e-01	0.114
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.684845e-01	0.114
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	7.684845e-01	0.114
Biotin transport and metabolism	R-HSA-196780	7.684845e-01	0.114
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	7.684845e-01	0.114
Protein methylation	R-HSA-8876725	7.684845e-01	0.114
DNA Damage Reversal	R-HSA-73942	7.684845e-01	0.114
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.705873e-01	0.113
Netrin mediated repulsion signals	R-HSA-418886	7.705873e-01	0.113
IFNG signaling activates MAPKs	R-HSA-9732724	7.705873e-01	0.113
DAG1 core M1 glycosylations	R-HSA-8932506	7.705873e-01	0.113
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.705873e-01	0.113
Recycling of eIF2:GDP	R-HSA-72731	7.705873e-01	0.113
mRNA Editing: C to U Conversion	R-HSA-72200	7.705873e-01	0.113
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.705873e-01	0.113
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.705873e-01	0.113
Glycoprotein hormones	R-HSA-209822	7.705873e-01	0.113
Phase 3 - rapid repolarisation	R-HSA-5576890	7.705873e-01	0.113
Uptake and function of diphtheria toxin	R-HSA-5336415	7.705873e-01	0.113
Nef Mediated CD4 Down-regulation	R-HSA-167590	7.705873e-01	0.113
Maturation of replicase proteins	R-HSA-9694301	7.705873e-01	0.113
Kidney development	R-HSA-9830369	7.720224e-01	0.112
Degradation of DVL	R-HSA-4641258	7.739930e-01	0.111
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	7.747099e-01	0.111
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.747099e-01	0.111
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.747099e-01	0.111
Proteasome assembly	R-HSA-9907900	7.753423e-01	0.111
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.766343e-01	0.110
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.778639e-01	0.109
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.793458e-01	0.108
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.793458e-01	0.108
FGFR2 alternative splicing	R-HSA-6803529	7.793458e-01	0.108
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.793458e-01	0.108
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.793458e-01	0.108
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.793458e-01	0.108
WNT ligand biogenesis and trafficking	R-HSA-3238698	7.793458e-01	0.108
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.810775e-01	0.107
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.810775e-01	0.107
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.810775e-01	0.107
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.810775e-01	0.107
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.810775e-01	0.107
Organelle biogenesis and maintenance	R-HSA-1852241	7.832677e-01	0.106
Developmental Cell Lineages	R-HSA-9734767	7.871869e-01	0.104
MET promotes cell motility	R-HSA-8875878	7.901489e-01	0.102
RIPK1-mediated regulated necrosis	R-HSA-5213460	7.901489e-01	0.102
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.901489e-01	0.102
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.917107e-01	0.101
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.920997e-01	0.101
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	7.923825e-01	0.101
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	7.923825e-01	0.101
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.923825e-01	0.101
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	7.923825e-01	0.101
Prolonged ERK activation events	R-HSA-169893	7.924475e-01	0.101
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	7.924475e-01	0.101
Regulation of BACH1 activity	R-HSA-9708530	7.924475e-01	0.101
Serotonin and melatonin biosynthesis	R-HSA-209931	7.924475e-01	0.101
Activation of SMO	R-HSA-5635838	7.924475e-01	0.101
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.924475e-01	0.101
HIV Life Cycle	R-HSA-162587	7.979906e-01	0.098
HCMV Late Events	R-HSA-9610379	7.979906e-01	0.098
Growth hormone receptor signaling	R-HSA-982772	7.988765e-01	0.098
Host Interactions of HIV factors	R-HSA-162909	7.994732e-01	0.097
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	8.000484e-01	0.097
Hemostasis	R-HSA-109582	8.002018e-01	0.097
Potential therapeutics for SARS	R-HSA-9679191	8.012390e-01	0.096
RSK activation	R-HSA-444257	8.020036e-01	0.096
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	8.020036e-01	0.096
DAG1 core M2 glycosylations	R-HSA-8932504	8.020036e-01	0.096
EGFR interacts with phospholipase C-gamma	R-HSA-212718	8.020036e-01	0.096
FGFR1b ligand binding and activation	R-HSA-190370	8.020036e-01	0.096
Myoclonic epilepsy of Lafora	R-HSA-3785653	8.020036e-01	0.096
MET receptor recycling	R-HSA-8875656	8.020036e-01	0.096
Regulation of NPAS4 mRNA translation	R-HSA-9768778	8.020036e-01	0.096
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	8.020036e-01	0.096
Sodium/Proton exchangers	R-HSA-425986	8.020036e-01	0.096
Interleukin-9 signaling	R-HSA-8985947	8.020036e-01	0.096
Downregulation of ERBB4 signaling	R-HSA-1253288	8.020036e-01	0.096
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	8.020036e-01	0.096
Activated NTRK2 signals through FYN	R-HSA-9032500	8.020036e-01	0.096
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.043777e-01	0.095
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.053886e-01	0.094
Cellular response to starvation	R-HSA-9711097	8.058788e-01	0.094
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.063856e-01	0.093
Signaling by PDGF	R-HSA-186797	8.063856e-01	0.093
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.089237e-01	0.092
Signaling by FGFR	R-HSA-190236	8.105622e-01	0.091
SHC1 events in ERBB4 signaling	R-HSA-1250347	8.141911e-01	0.089
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	8.141911e-01	0.089
Passive transport by Aquaporins	R-HSA-432047	8.141911e-01	0.089
Synthesis of PG	R-HSA-1483148	8.141911e-01	0.089
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.161934e-01	0.088
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.169369e-01	0.088
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.169369e-01	0.088
TNFs bind their physiological receptors	R-HSA-5669034	8.169369e-01	0.088
Interleukin-6 family signaling	R-HSA-6783589	8.169369e-01	0.088
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.174322e-01	0.088
G alpha (z) signalling events	R-HSA-418597	8.174322e-01	0.088
Recycling pathway of L1	R-HSA-437239	8.177590e-01	0.087
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.177590e-01	0.087
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.197364e-01	0.086
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.197364e-01	0.086
IPs transport between nucleus and cytosol	R-HSA-1855170	8.243728e-01	0.084
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.264305e-01	0.083
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	8.285180e-01	0.082
MASTL Facilitates Mitotic Progression	R-HSA-2465910	8.291192e-01	0.081
Activation of the AP-1 family of transcription factors	R-HSA-450341	8.291192e-01	0.081
Interleukin-21 signaling	R-HSA-9020958	8.291192e-01	0.081
ARMS-mediated activation	R-HSA-170984	8.291192e-01	0.081
Regulation of signaling by NODAL	R-HSA-1433617	8.291192e-01	0.081
mRNA Editing	R-HSA-75072	8.291192e-01	0.081
Regulation of NPAS4 gene transcription	R-HSA-9768777	8.291192e-01	0.081
Respiratory syncytial virus genome replication	R-HSA-9834752	8.291192e-01	0.081
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	8.291192e-01	0.081
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.291192e-01	0.081
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	8.291192e-01	0.081
Cellular response to mitochondrial stress	R-HSA-9840373	8.291192e-01	0.081
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	8.316943e-01	0.080
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.332192e-01	0.079
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.335993e-01	0.079
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.335993e-01	0.079
G protein gated Potassium channels	R-HSA-1296059	8.335993e-01	0.079
Activation of G protein gated Potassium channels	R-HSA-1296041	8.335993e-01	0.079
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.335993e-01	0.079
Acyl chain remodelling of PS	R-HSA-1482801	8.335993e-01	0.079
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.338735e-01	0.079
Regulation of FZD by ubiquitination	R-HSA-4641263	8.338735e-01	0.079
Regulation of NPAS4 gene expression	R-HSA-9768759	8.338735e-01	0.079
Uptake and function of anthrax toxins	R-HSA-5210891	8.338735e-01	0.079
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.338735e-01	0.079
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.387705e-01	0.076
DNA Damage Recognition in GG-NER	R-HSA-5696394	8.387724e-01	0.076
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	8.387724e-01	0.076
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.387724e-01	0.076
Miscellaneous transport and binding events	R-HSA-5223345	8.387724e-01	0.076
HCMV Infection	R-HSA-9609646	8.410661e-01	0.075
DNA Damage Bypass	R-HSA-73893	8.423414e-01	0.075
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.443767e-01	0.073
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.458667e-01	0.073
HIV Transcription Initiation	R-HSA-167161	8.458667e-01	0.073
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.458667e-01	0.073
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.458667e-01	0.073
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.458667e-01	0.073
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.489386e-01	0.071
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.489386e-01	0.071
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.489386e-01	0.071
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.516515e-01	0.070
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.516515e-01	0.070
Dual Incision in GG-NER	R-HSA-5696400	8.521680e-01	0.069
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.521680e-01	0.069
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.521680e-01	0.069
Mitophagy	R-HSA-5205647	8.521680e-01	0.069
Nuclear import of Rev protein	R-HSA-180746	8.521680e-01	0.069
DNA replication initiation	R-HSA-68952	8.525227e-01	0.069
Folding of actin by CCT/TriC	R-HSA-390450	8.525227e-01	0.069
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.525227e-01	0.069
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	8.525227e-01	0.069
Formation of intermediate mesoderm	R-HSA-9761174	8.525227e-01	0.069
Arachidonate production from DAG	R-HSA-426048	8.525227e-01	0.069
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.525227e-01	0.069
Pexophagy	R-HSA-9664873	8.525227e-01	0.069
Interleukin-27 signaling	R-HSA-9020956	8.525227e-01	0.069
Maturation of spike protein	R-HSA-9683686	8.525227e-01	0.069
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.525227e-01	0.069
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	8.525227e-01	0.069
Sperm Motility And Taxes	R-HSA-1300642	8.525227e-01	0.069
Defective factor IX causes hemophilia B	R-HSA-9668250	8.525227e-01	0.069
Peptide hormone biosynthesis	R-HSA-209952	8.525227e-01	0.069
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.527253e-01	0.069
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.593413e-01	0.066
Triglyceride metabolism	R-HSA-8979227	8.613763e-01	0.065
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.630313e-01	0.064
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.631516e-01	0.064
Hedgehog ligand biogenesis	R-HSA-5358346	8.641633e-01	0.063
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	8.646067e-01	0.063
Signalling to ERKs	R-HSA-187687	8.646067e-01	0.063
Regulation of Apoptosis	R-HSA-169911	8.646067e-01	0.063
Mitochondrial biogenesis	R-HSA-1592230	8.651430e-01	0.063
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.676774e-01	0.062
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.676774e-01	0.062
Maturation of nucleoprotein	R-HSA-9694631	8.676774e-01	0.062
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.676774e-01	0.062
Other interleukin signaling	R-HSA-449836	8.676774e-01	0.062
UCH proteinases	R-HSA-5689603	8.680028e-01	0.061
Signaling by NOTCH1	R-HSA-1980143	8.680028e-01	0.061
RNA Polymerase II Promoter Escape	R-HSA-73776	8.687831e-01	0.061
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	8.687831e-01	0.061
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.687831e-01	0.061
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.689848e-01	0.061
GABA receptor activation	R-HSA-977443	8.708994e-01	0.060
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.708994e-01	0.060
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.727220e-01	0.059
DAG1 core M3 glycosylations	R-HSA-8932505	8.727220e-01	0.059
FGFR2b ligand binding and activation	R-HSA-190377	8.727220e-01	0.059
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.727220e-01	0.059
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.727220e-01	0.059
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.727220e-01	0.059
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.727220e-01	0.059
LGI-ADAM interactions	R-HSA-5682910	8.727220e-01	0.059
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	8.727220e-01	0.059
Suppression of apoptosis	R-HSA-9635465	8.727220e-01	0.059
Transport of RCbl within the body	R-HSA-9758890	8.727220e-01	0.059
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	8.740992e-01	0.058
Uptake and actions of bacterial toxins	R-HSA-5339562	8.740992e-01	0.058
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.759541e-01	0.058
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.759541e-01	0.058
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.759541e-01	0.058
Pyrimidine salvage	R-HSA-73614	8.759541e-01	0.058
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.761366e-01	0.057
HSF1 activation	R-HSA-3371511	8.761366e-01	0.057
RNA Polymerase III Transcription	R-HSA-74158	8.761366e-01	0.057
Lysosome Vesicle Biogenesis	R-HSA-432720	8.761366e-01	0.057
RUNX2 regulates bone development	R-HSA-8941326	8.761366e-01	0.057
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	8.803034e-01	0.055
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.820976e-01	0.054
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.820976e-01	0.054
Signal transduction by L1	R-HSA-445144	8.820976e-01	0.054
Signaling by Insulin receptor	R-HSA-74752	8.828930e-01	0.054
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.832496e-01	0.054
PCP/CE pathway	R-HSA-4086400	8.841534e-01	0.053
Neutrophil degranulation	R-HSA-6798695	8.852157e-01	0.053
Platelet degranulation	R-HSA-114608	8.859466e-01	0.053
TRAF6 mediated IRF7 activation	R-HSA-933541	8.868063e-01	0.052
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.868063e-01	0.052
Degradation of AXIN	R-HSA-4641257	8.868063e-01	0.052
mRNA Capping	R-HSA-72086	8.877829e-01	0.052
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.877829e-01	0.052
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.887516e-01	0.051
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.887516e-01	0.051
Somitogenesis	R-HSA-9824272	8.887516e-01	0.051
PI3K events in ERBB4 signaling	R-HSA-1250342	8.901558e-01	0.051
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.901558e-01	0.051
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.901558e-01	0.051
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.901558e-01	0.051
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.901558e-01	0.051
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	8.901558e-01	0.051
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.921490e-01	0.050
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.934678e-01	0.049
MyD88 deficiency (TLR2/4)	R-HSA-5602498	8.950511e-01	0.048
Signalling to RAS	R-HSA-167044	8.950511e-01	0.048
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.950511e-01	0.048
Basigin interactions	R-HSA-210991	8.950511e-01	0.048
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	8.966642e-01	0.047
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.985920e-01	0.046
PKR-mediated signaling	R-HSA-9833482	8.986403e-01	0.046
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	8.991363e-01	0.046
Scavenging by Class F Receptors	R-HSA-3000484	9.052024e-01	0.043
Regulation of IFNG signaling	R-HSA-877312	9.052024e-01	0.043
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.052024e-01	0.043
Interleukin-35 Signalling	R-HSA-8984722	9.052024e-01	0.043
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	9.052024e-01	0.043
Estrogen biosynthesis	R-HSA-193144	9.052024e-01	0.043
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.052960e-01	0.043
NS1 Mediated Effects on Host Pathways	R-HSA-168276	9.057582e-01	0.043
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.066692e-01	0.043
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.066692e-01	0.043
Mitochondrial calcium ion transport	R-HSA-8949215	9.066692e-01	0.043
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.079451e-01	0.042
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.081517e-01	0.042
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.084536e-01	0.042
Cellular response to hypoxia	R-HSA-1234174	9.107294e-01	0.041
SARS-CoV-1 Infection	R-HSA-9678108	9.124611e-01	0.040
Intraflagellar transport	R-HSA-5620924	9.137804e-01	0.039
Metal ion SLC transporters	R-HSA-425410	9.137804e-01	0.039
Signaling by NOTCH4	R-HSA-9013694	9.139961e-01	0.039
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.141352e-01	0.039
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.141352e-01	0.039
Interactions of Rev with host cellular proteins	R-HSA-177243	9.141352e-01	0.039
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.141352e-01	0.039
COPI-mediated anterograde transport	R-HSA-6807878	9.143116e-01	0.039
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.170746e-01	0.038
Neurotoxicity of clostridium toxins	R-HSA-168799	9.170746e-01	0.038
RAF-independent MAPK1/3 activation	R-HSA-112409	9.170746e-01	0.038
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.170746e-01	0.038
Cytoprotection by HMOX1	R-HSA-9707564	9.175058e-01	0.037
Adenylate cyclase activating pathway	R-HSA-170660	9.181887e-01	0.037
FGFR2c ligand binding and activation	R-HSA-190375	9.181887e-01	0.037
FGFR1c ligand binding and activation	R-HSA-190373	9.181887e-01	0.037
Processing of SMDT1	R-HSA-8949664	9.181887e-01	0.037
FGFR4 ligand binding and activation	R-HSA-190322	9.181887e-01	0.037
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	9.181887e-01	0.037
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.181887e-01	0.037
Acetylcholine binding and downstream events	R-HSA-181431	9.181887e-01	0.037
Chylomicron remodeling	R-HSA-8963901	9.181887e-01	0.037
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.181887e-01	0.037
Reversible hydration of carbon dioxide	R-HSA-1475029	9.181887e-01	0.037
PI5P Regulates TP53 Acetylation	R-HSA-6811555	9.181887e-01	0.037
FGFR3 mutant receptor activation	R-HSA-2033514	9.181887e-01	0.037
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	9.181887e-01	0.037
rRNA modification in the mitochondrion	R-HSA-6793080	9.181887e-01	0.037
Platelet Adhesion to exposed collagen	R-HSA-75892	9.181887e-01	0.037
Dual incision in TC-NER	R-HSA-6782135	9.216989e-01	0.035
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.216989e-01	0.035
Maturation of spike protein	R-HSA-9694548	9.218411e-01	0.035
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.218411e-01	0.035
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.218411e-01	0.035
Hh mutants are degraded by ERAD	R-HSA-5362768	9.218411e-01	0.035
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.263814e-01	0.033
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.263814e-01	0.033
Formation of the ureteric bud	R-HSA-9830674	9.263814e-01	0.033
Carnitine shuttle	R-HSA-200425	9.263814e-01	0.033
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.263814e-01	0.033
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.293966e-01	0.032
FGFR3c ligand binding and activation	R-HSA-190372	9.293966e-01	0.032
Hydrolysis of LPC	R-HSA-1483115	9.293966e-01	0.032
Prolactin receptor signaling	R-HSA-1170546	9.293966e-01	0.032
Physiological factors	R-HSA-5578768	9.293966e-01	0.032
Glycerophospholipid catabolism	R-HSA-6814848	9.293966e-01	0.032
Malate-aspartate shuttle	R-HSA-9856872	9.293966e-01	0.032
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.293966e-01	0.032
Ciprofloxacin ADME	R-HSA-9793528	9.293966e-01	0.032
HDL assembly	R-HSA-8963896	9.293966e-01	0.032
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	9.293966e-01	0.032
Signal regulatory protein family interactions	R-HSA-391160	9.293966e-01	0.032
Zinc transporters	R-HSA-435354	9.293966e-01	0.032
Phospholipid metabolism	R-HSA-1483257	9.323822e-01	0.030
Acyl chain remodelling of PC	R-HSA-1482788	9.330324e-01	0.030
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.330324e-01	0.030
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.346953e-01	0.029
Activation of GABAB receptors	R-HSA-991365	9.354148e-01	0.029
GABA B receptor activation	R-HSA-977444	9.354148e-01	0.029
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.358844e-01	0.029
Formation of paraxial mesoderm	R-HSA-9793380	9.389509e-01	0.027
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	9.390697e-01	0.027
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.390697e-01	0.027
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.390697e-01	0.027
G beta:gamma signalling through BTK	R-HSA-8964315	9.390697e-01	0.027
RNA Polymerase III Chain Elongation	R-HSA-73780	9.390697e-01	0.027
Signaling by Activin	R-HSA-1502540	9.390697e-01	0.027
FGFR3 ligand binding and activation	R-HSA-190239	9.390697e-01	0.027
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.390697e-01	0.027
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	9.390697e-01	0.027
Other semaphorin interactions	R-HSA-416700	9.390697e-01	0.027
COPII-mediated vesicle transport	R-HSA-204005	9.395075e-01	0.027
GPCR downstream signalling	R-HSA-388396	9.438074e-01	0.025
Amino acids regulate mTORC1	R-HSA-9639288	9.446058e-01	0.025
Smooth Muscle Contraction	R-HSA-445355	9.446058e-01	0.025
Transferrin endocytosis and recycling	R-HSA-917977	9.458700e-01	0.024
PERK regulates gene expression	R-HSA-381042	9.458700e-01	0.024
Acyl chain remodelling of PE	R-HSA-1482839	9.458700e-01	0.024
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.474179e-01	0.023
Defective GALNT3 causes HFTC	R-HSA-5083625	9.474179e-01	0.023
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.474179e-01	0.023
Killing mechanisms	R-HSA-9664420	9.474179e-01	0.023
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.474179e-01	0.023
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	9.474179e-01	0.023
Induction of Cell-Cell Fusion	R-HSA-9733458	9.474179e-01	0.023
Fructose catabolism	R-HSA-70350	9.474179e-01	0.023
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.474179e-01	0.023
Atorvastatin ADME	R-HSA-9754706	9.474179e-01	0.023
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.487256e-01	0.023
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.487256e-01	0.023
Abacavir ADME	R-HSA-2161522	9.487256e-01	0.023
Sphingolipid catabolism	R-HSA-9845614	9.487256e-01	0.023
FGFR2 mutant receptor activation	R-HSA-1839126	9.513933e-01	0.022
Inositol phosphate metabolism	R-HSA-1483249	9.515730e-01	0.022
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	9.517926e-01	0.021
Influenza Infection	R-HSA-168255	9.524139e-01	0.021
G alpha (s) signalling events	R-HSA-418555	9.524959e-01	0.021
G beta:gamma signalling through CDC42	R-HSA-8964616	9.546228e-01	0.020
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.546228e-01	0.020
Coenzyme A biosynthesis	R-HSA-196783	9.546228e-01	0.020
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.546228e-01	0.020
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.546228e-01	0.020
Nucleotide Excision Repair	R-HSA-5696398	9.562575e-01	0.019
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.563400e-01	0.019
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.563400e-01	0.019
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.563400e-01	0.019
Voltage gated Potassium channels	R-HSA-1296072	9.563868e-01	0.019
SLC-mediated transport of organic cations	R-HSA-549127	9.563868e-01	0.019
SARS-CoV-2-host interactions	R-HSA-9705683	9.577124e-01	0.019
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.579269e-01	0.019
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.597531e-01	0.018
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.598119e-01	0.018
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.598500e-01	0.018
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	9.598500e-01	0.018
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.604883e-01	0.018
Interferon gamma signaling	R-HSA-877300	9.605048e-01	0.018
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.608408e-01	0.017
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.608408e-01	0.017
Glycogen storage diseases	R-HSA-3229121	9.608408e-01	0.017
Catecholamine biosynthesis	R-HSA-209905	9.608408e-01	0.017
GDP-fucose biosynthesis	R-HSA-6787639	9.608408e-01	0.017
Choline catabolism	R-HSA-6798163	9.608408e-01	0.017
ABC-family proteins mediated transport	R-HSA-382556	9.638333e-01	0.016
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.645045e-01	0.016
Glucagon-type ligand receptors	R-HSA-420092	9.645045e-01	0.016
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.649648e-01	0.015
rRNA processing	R-HSA-72312	9.654572e-01	0.015
G beta:gamma signalling through PLC beta	R-HSA-418217	9.662071e-01	0.015
RNA Polymerase III Transcription Termination	R-HSA-73980	9.662071e-01	0.015
Activated point mutants of FGFR2	R-HSA-2033519	9.662071e-01	0.015
FGFR1 ligand binding and activation	R-HSA-190242	9.662071e-01	0.015
Presynaptic function of Kainate receptors	R-HSA-500657	9.662071e-01	0.015
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.662071e-01	0.015
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.662071e-01	0.015
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.662071e-01	0.015
Parasitic Infection Pathways	R-HSA-9824443	9.680029e-01	0.014
Leishmania infection	R-HSA-9658195	9.680029e-01	0.014
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.682538e-01	0.014
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.686317e-01	0.014
Neurotransmitter clearance	R-HSA-112311	9.686376e-01	0.014
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.686376e-01	0.014
ER to Golgi Anterograde Transport	R-HSA-199977	9.701502e-01	0.013
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.708382e-01	0.013
Diseases of hemostasis	R-HSA-9671793	9.708382e-01	0.013
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.723049e-01	0.012
Cargo concentration in the ER	R-HSA-5694530	9.723049e-01	0.012
Evasion by RSV of host interferon responses	R-HSA-9833109	9.723049e-01	0.012
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.723049e-01	0.012
The phototransduction cascade	R-HSA-2514856	9.736853e-01	0.012
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.736853e-01	0.012
Viral Messenger RNA Synthesis	R-HSA-168325	9.737780e-01	0.012
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.748349e-01	0.011
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.748349e-01	0.011
Glycogen synthesis	R-HSA-3322077	9.748349e-01	0.011
Acyl chain remodelling of PI	R-HSA-1482922	9.748349e-01	0.011
Pregnenolone biosynthesis	R-HSA-196108	9.748349e-01	0.011
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.749040e-01	0.011
Intra-Golgi traffic	R-HSA-6811438	9.749040e-01	0.011
Translation of Structural Proteins	R-HSA-9683701	9.749040e-01	0.011
ER-Phagosome pathway	R-HSA-1236974	9.753266e-01	0.011
Mitochondrial protein import	R-HSA-1268020	9.761917e-01	0.010
NCAM signaling for neurite out-growth	R-HSA-375165	9.761917e-01	0.010
G alpha (q) signalling events	R-HSA-416476	9.771784e-01	0.010
FGFR2 ligand binding and activation	R-HSA-190241	9.782841e-01	0.010
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.782841e-01	0.010
G-protein activation	R-HSA-202040	9.782841e-01	0.010
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.782841e-01	0.010
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.782841e-01	0.010
Phenylalanine metabolism	R-HSA-8964208	9.782841e-01	0.010
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.782841e-01	0.010
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.782841e-01	0.010
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.782841e-01	0.010
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.782841e-01	0.010
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.784231e-01	0.009
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.784369e-01	0.009
Heme degradation	R-HSA-189483	9.809873e-01	0.008
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.812606e-01	0.008
Molybdenum cofactor biosynthesis	R-HSA-947581	9.812606e-01	0.008
Serine metabolism	R-HSA-977347	9.812606e-01	0.008
Glutathione synthesis and recycling	R-HSA-174403	9.812606e-01	0.008
Antigen processing-Cross presentation	R-HSA-1236975	9.818650e-01	0.008
Iron uptake and transport	R-HSA-917937	9.824493e-01	0.008
Citric acid cycle (TCA cycle)	R-HSA-71403	9.824493e-01	0.008
Paracetamol ADME	R-HSA-9753281	9.826573e-01	0.008
Selenoamino acid metabolism	R-HSA-2408522	9.828654e-01	0.008
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.832439e-01	0.007
eNOS activation	R-HSA-203615	9.832439e-01	0.007
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.832439e-01	0.007
Signaling by NOTCH2	R-HSA-1980145	9.832439e-01	0.007
Fructose metabolism	R-HSA-5652084	9.838294e-01	0.007
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.838294e-01	0.007
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.839195e-01	0.007
Metabolism of amine-derived hormones	R-HSA-209776	9.843976e-01	0.007
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.849414e-01	0.007
Mitochondrial protein degradation	R-HSA-9837999	9.851637e-01	0.006
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.852392e-01	0.006
Translation of Structural Proteins	R-HSA-9694635	9.854588e-01	0.006
Regulation of PTEN mRNA translation	R-HSA-8943723	9.860461e-01	0.006
Termination of O-glycan biosynthesis	R-HSA-977068	9.860461e-01	0.006
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.860461e-01	0.006
Free fatty acids regulate insulin secretion	R-HSA-400451	9.860461e-01	0.006
Biosynthesis of maresins	R-HSA-9018682	9.860461e-01	0.006
Interleukin-20 family signaling	R-HSA-8854691	9.860461e-01	0.006
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.860461e-01	0.006
Organic anion transport by SLCO transporters	R-HSA-879518	9.860461e-01	0.006
Signaling by GPCR	R-HSA-372790	9.860757e-01	0.006
ABC transporter disorders	R-HSA-5619084	9.867751e-01	0.006
Integrin cell surface interactions	R-HSA-216083	9.867751e-01	0.006
Interleukin-10 signaling	R-HSA-6783783	9.867751e-01	0.006
Glycosphingolipid transport	R-HSA-9845576	9.870025e-01	0.006
Chaperonin-mediated protein folding	R-HSA-390466	9.870489e-01	0.006
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.873933e-01	0.006
CYP2E1 reactions	R-HSA-211999	9.879591e-01	0.005
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.879591e-01	0.005
Thromboxane signalling through TP receptor	R-HSA-428930	9.879591e-01	0.005
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.879591e-01	0.005
Synthesis of dolichyl-phosphate	R-HSA-446199	9.879591e-01	0.005
Plasma lipoprotein assembly	R-HSA-8963898	9.879591e-01	0.005
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.885599e-01	0.005
NCAM1 interactions	R-HSA-419037	9.885599e-01	0.005
Collagen chain trimerization	R-HSA-8948216	9.885599e-01	0.005
Gluconeogenesis	R-HSA-70263	9.887175e-01	0.005
FCERI mediated NF-kB activation	R-HSA-2871837	9.887273e-01	0.005
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.894541e-01	0.005
Alpha-oxidation of phytanate	R-HSA-389599	9.896099e-01	0.005
Fertilization	R-HSA-1187000	9.896099e-01	0.005
Laminin interactions	R-HSA-3000157	9.896099e-01	0.005
Metabolism of polyamines	R-HSA-351202	9.898359e-01	0.004
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.899347e-01	0.004
Collagen degradation	R-HSA-1442490	9.908807e-01	0.004
MET activates PTK2 signaling	R-HSA-8874081	9.910345e-01	0.004
Urea cycle	R-HSA-70635	9.910345e-01	0.004
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.910345e-01	0.004
Suppression of phagosomal maturation	R-HSA-9637687	9.910345e-01	0.004
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.912737e-01	0.004
tRNA processing in the nucleus	R-HSA-6784531	9.918222e-01	0.004
SARS-CoV-2 Infection	R-HSA-9694516	9.922117e-01	0.003
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.922173e-01	0.003
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.922638e-01	0.003
Triglyceride biosynthesis	R-HSA-75109	9.922638e-01	0.003
Synthesis of PE	R-HSA-1483213	9.922638e-01	0.003
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.922638e-01	0.003
Signaling by BMP	R-HSA-201451	9.922638e-01	0.003
Maturation of hRSV A proteins	R-HSA-9828806	9.922638e-01	0.003
Protein folding	R-HSA-391251	9.925630e-01	0.003
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.925630e-01	0.003
SARS-CoV Infections	R-HSA-9679506	9.926860e-01	0.003
ROS and RNS production in phagocytes	R-HSA-1222556	9.928592e-01	0.003
Interferon Signaling	R-HSA-913531	9.932469e-01	0.003
Insulin receptor recycling	R-HSA-77387	9.933246e-01	0.003
Prednisone ADME	R-HSA-9757110	9.933246e-01	0.003
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.933246e-01	0.003
Collagen formation	R-HSA-1474290	9.938426e-01	0.003
Thyroxine biosynthesis	R-HSA-209968	9.942400e-01	0.003
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.942400e-01	0.003
Immune System	R-HSA-168256	9.947664e-01	0.002
SLC-mediated transport of amino acids	R-HSA-9958863	9.952913e-01	0.002
Defensins	R-HSA-1461973	9.953662e-01	0.002
Response of Mtb to phagocytosis	R-HSA-9637690	9.953662e-01	0.002
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.957116e-01	0.002
Molecules associated with elastic fibres	R-HSA-2129379	9.957116e-01	0.002
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.959329e-01	0.002
Viral Infection Pathways	R-HSA-9824446	9.961280e-01	0.002
DAG1 glycosylations	R-HSA-8931838	9.962998e-01	0.002
Neurotransmitter release cycle	R-HSA-112310	9.963211e-01	0.002
Neddylation	R-HSA-8951664	9.967257e-01	0.001
Defective B3GALTL causes PpS	R-HSA-5083635	9.968073e-01	0.001
Recycling of bile acids and salts	R-HSA-159418	9.968073e-01	0.001
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.968073e-01	0.001
Regulation of pyruvate metabolism	R-HSA-9861718	9.968695e-01	0.001
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.968899e-01	0.001
Amino acid transport across the plasma membrane	R-HSA-352230	9.969380e-01	0.001
Peroxisomal protein import	R-HSA-9033241	9.969380e-01	0.001
ECM proteoglycans	R-HSA-3000178	9.969963e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.969963e-01	0.001
G alpha (i) signalling events	R-HSA-418594	9.970788e-01	0.001
Protein localization	R-HSA-9609507	9.972424e-01	0.001
Synthesis of PC	R-HSA-1483191	9.972547e-01	0.001
Signaling by Retinoic Acid	R-HSA-5362517	9.972869e-01	0.001
Nucleotide salvage	R-HSA-8956321	9.975969e-01	0.001
Signal amplification	R-HSA-392518	9.976231e-01	0.001
RA biosynthesis pathway	R-HSA-5365859	9.976231e-01	0.001
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.976231e-01	0.001
Calnexin/calreticulin cycle	R-HSA-901042	9.976231e-01	0.001
Hyaluronan metabolism	R-HSA-2142845	9.976231e-01	0.001
PPARA activates gene expression	R-HSA-1989781	9.976617e-01	0.001
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.979492e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.980201e-01	0.001
RSV-host interactions	R-HSA-9833110	9.980884e-01	0.001
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.982306e-01	0.001
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.984733e-01	0.001
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.984733e-01	0.001
Lysine catabolism	R-HSA-71064	9.984733e-01	0.001
Role of phospholipids in phagocytosis	R-HSA-2029485	9.985203e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.986528e-01	0.001
Elastic fibre formation	R-HSA-1566948	9.986828e-01	0.001
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.988004e-01	0.001
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.988636e-01	0.000
Pentose phosphate pathway	R-HSA-71336	9.988636e-01	0.000
RAS processing	R-HSA-9648002	9.988636e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.989817e-01	0.000
rRNA processing in the mitochondrion	R-HSA-8868766	9.990195e-01	0.000
Tryptophan catabolism	R-HSA-71240	9.990195e-01	0.000
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.991541e-01	0.000
SLC transporter disorders	R-HSA-5619102	9.991555e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.992055e-01	0.000
Heme biosynthesis	R-HSA-189451	9.992702e-01	0.000
Dectin-2 family	R-HSA-5621480	9.992715e-01	0.000
Synthesis of PA	R-HSA-1483166	9.992715e-01	0.000
Parasite infection	R-HSA-9664407	9.992790e-01	0.000
Leishmania phagocytosis	R-HSA-9664417	9.992790e-01	0.000
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.992790e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.992984e-01	0.000
Cytosolic tRNA aminoacylation	R-HSA-379716	9.993703e-01	0.000
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.993703e-01	0.000
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.993807e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.995312e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.995313e-01	0.000
Transport to the Golgi and subsequent modification	R-HSA-948021	9.995404e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.995435e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.995435e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.995898e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.996244e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.996747e-01	0.000
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.996991e-01	0.000
Plasma lipoprotein remodeling	R-HSA-8963899	9.997404e-01	0.000
Gap junction trafficking and regulation	R-HSA-157858	9.997760e-01	0.000
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.997760e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.997760e-01	0.000
Azathioprine ADME	R-HSA-9748787	9.998068e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998106e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.998106e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998167e-01	0.000
Complex IV assembly	R-HSA-9864848	9.998333e-01	0.000
Branched-chain amino acid catabolism	R-HSA-70895	9.998333e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.998346e-01	0.000
Nucleotide biosynthesis	R-HSA-8956320	9.998760e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.998893e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.998900e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.998920e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999163e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.999186e-01	0.000
Digestion	R-HSA-8935690	9.999204e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999233e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.999339e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999341e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999447e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999536e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.999559e-01	0.000
Glutathione conjugation	R-HSA-156590	9.999559e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999578e-01	0.000
Endogenous sterols	R-HSA-211976	9.999620e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999634e-01	0.000
Interferon alpha/beta signaling	R-HSA-909733	9.999634e-01	0.000
Digestion and absorption	R-HSA-8963743	9.999717e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999744e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.999756e-01	0.000
Xenobiotics	R-HSA-211981	9.999756e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.999756e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999804e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999815e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999826e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.999843e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999849e-01	0.000
Innate Immune System	R-HSA-168249	9.999863e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.999876e-01	0.000
tRNA processing	R-HSA-72306	9.999906e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999907e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999913e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999922e-01	0.000
Purine catabolism	R-HSA-74259	9.999925e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999936e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.999954e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999969e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999969e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999973e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999980e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999980e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999989e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999992e-01	0.000
Translation	R-HSA-72766	9.999992e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999993e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999996e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999996e-01	0.000
Transport of small molecules	R-HSA-382551	9.999997e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999997e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999998e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999998e-01	0.000
Disease	R-HSA-1643685	9.999999e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999999e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999999e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Eukaryotic Translation Initiation	R-HSA-72613	1.483234e-07	6.829
Cap-dependent Translation Initiation	R-HSA-72737	1.483234e-07	6.829
Translation initiation complex formation	R-HSA-72649	5.210919e-07	6.283
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	4.504296e-07	6.346
Ribosomal scanning and start codon recognition	R-HSA-72702	8.993930e-07	6.046
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.170766e-06	5.932
mRNA Splicing - Major Pathway	R-HSA-72163	1.719088e-06	5.765
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.793652e-06	5.746
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	3.044773e-06	5.516
mRNA Splicing	R-HSA-72172	3.230301e-06	5.491
M Phase	R-HSA-68886	3.663794e-06	5.436
Chaperone Mediated Autophagy	R-HSA-9613829	4.356967e-06	5.361
Metabolism of RNA	R-HSA-8953854	9.546321e-06	5.020
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.612115e-05	4.793
Signaling by ALK in cancer	R-HSA-9700206	1.612115e-05	4.793
Cell-extracellular matrix interactions	R-HSA-446353	1.871783e-05	4.728
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	2.766941e-05	4.558
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.627806e-05	4.580
Cell Cycle	R-HSA-1640170	2.645856e-05	4.577
Apoptotic execution phase	R-HSA-75153	2.766941e-05	4.558
Eukaryotic Translation Elongation	R-HSA-156842	3.724785e-05	4.429
Cellular responses to stimuli	R-HSA-8953897	4.006077e-05	4.397
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.104759e-05	4.387
Axon guidance	R-HSA-422475	4.417932e-05	4.355
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.357604e-05	4.271
Cellular responses to stress	R-HSA-2262752	5.908516e-05	4.229
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.528940e-05	4.185
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.603913e-05	4.180
Nervous system development	R-HSA-9675108	7.557458e-05	4.122
Late endosomal microautophagy	R-HSA-9615710	8.170560e-05	4.088
Membrane Trafficking	R-HSA-199991	8.142117e-05	4.089
Mitotic Anaphase	R-HSA-68882	9.472573e-05	4.024
Chromatin organization	R-HSA-4839726	9.993872e-05	4.000
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.044626e-04	3.981
Cellular Senescence	R-HSA-2559583	1.065317e-04	3.973
Cell Cycle, Mitotic	R-HSA-69278	1.051772e-04	3.978
Mitotic Prometaphase	R-HSA-68877	1.107053e-04	3.956
Cell Cycle Checkpoints	R-HSA-69620	1.242823e-04	3.906
p75 NTR receptor-mediated signalling	R-HSA-193704	1.300490e-04	3.886
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.402465e-04	3.853
Signaling by ROBO receptors	R-HSA-376176	1.591462e-04	3.798
Josephin domain DUBs	R-HSA-5689877	1.672633e-04	3.777
Formation of a pool of free 40S subunits	R-HSA-72689	1.678891e-04	3.775
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.975508e-04	3.704
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.129485e-04	3.672
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.360575e-04	3.627
Separation of Sister Chromatids	R-HSA-2467813	2.546560e-04	3.594
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.337451e-04	3.477
SWI/SNF chromatin remodelers	R-HSA-9932451	3.422230e-04	3.466
ATP-dependent chromatin remodelers	R-HSA-9932444	3.422230e-04	3.466
Ribosome-associated quality control	R-HSA-9948299	4.089267e-04	3.388
Autophagy	R-HSA-9612973	4.149033e-04	3.382
Interleukin-12 signaling	R-HSA-9020591	4.468688e-04	3.350
Chromatin modifying enzymes	R-HSA-3247509	4.860495e-04	3.313
Signaling by NOTCH3	R-HSA-9012852	5.369757e-04	3.270
Peptide chain elongation	R-HSA-156902	5.582561e-04	3.253
PKMTs methylate histone lysines	R-HSA-3214841	6.236882e-04	3.205
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.858470e-04	3.105
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.867330e-04	3.104
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	9.590683e-04	3.018
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.602023e-04	3.018
Striated Muscle Contraction	R-HSA-390522	9.857911e-04	3.006
Signaling by NOTCH2	R-HSA-1980145	1.225330e-03	2.912
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.216104e-03	2.915
Selective autophagy	R-HSA-9663891	1.242615e-03	2.906
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.225330e-03	2.912
Macroautophagy	R-HSA-1632852	1.097828e-03	2.959
rRNA processing	R-HSA-72312	1.228903e-03	2.910
Transcriptional regulation by RUNX3	R-HSA-8878159	1.089220e-03	2.963
Transcriptional Regulation by E2F6	R-HSA-8953750	1.189219e-03	2.925
Regulation of PTEN localization	R-HSA-8948747	1.222505e-03	2.913
Death Receptor Signaling	R-HSA-73887	1.222987e-03	2.913
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.265039e-03	2.898
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.265039e-03	2.898
Cell-Cell communication	R-HSA-1500931	1.310623e-03	2.883
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.371570e-03	2.863
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.410700e-03	2.851
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.413406e-03	2.850
Aggrephagy	R-HSA-9646399	1.448450e-03	2.839
FLT3 signaling by CBL mutants	R-HSA-9706377	1.462173e-03	2.835
Mitotic Spindle Checkpoint	R-HSA-69618	1.568114e-03	2.805
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.819230e-03	2.740
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.967029e-03	2.706
Epigenetic regulation of gene expression	R-HSA-212165	2.058913e-03	2.686
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.221203e-03	2.653
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.349526e-03	2.629
Interleukin-12 family signaling	R-HSA-447115	2.352933e-03	2.628
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.402439e-03	2.619
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.738937e-03	2.562
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.667303e-03	2.574
Cell junction organization	R-HSA-446728	2.759223e-03	2.559
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.922917e-03	2.534
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.922917e-03	2.534
Kinesins	R-HSA-983189	2.992420e-03	2.524
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.297189e-03	2.482
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.297189e-03	2.482
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.213452e-03	2.493
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.756864e-03	2.425
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.756864e-03	2.425
Eukaryotic Translation Termination	R-HSA-72764	3.673609e-03	2.435
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.822012e-03	2.418
Amplification of signal from the kinetochores	R-HSA-141424	3.871891e-03	2.412
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.871891e-03	2.412
NRAGE signals death through JNK	R-HSA-193648	3.896553e-03	2.409
Regulation of endogenous retroelements	R-HSA-9842860	3.957144e-03	2.403
Translation	R-HSA-72766	4.209487e-03	2.376
Signaling by NOTCH4	R-HSA-9013694	3.988554e-03	2.399
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.224353e-03	2.374
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.424256e-03	2.354
Regulation of CDH1 Function	R-HSA-9764561	4.499774e-03	2.347
Budding and maturation of HIV virion	R-HSA-162588	4.512051e-03	2.346
Semaphorin interactions	R-HSA-373755	4.555608e-03	2.341
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.555608e-03	2.341
Degradation of beta-catenin by the destruction complex	R-HSA-195253	5.179347e-03	2.286
Signaling by NOTCH1	R-HSA-1980143	5.109909e-03	2.292
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.461090e-03	2.263
NRIF signals cell death from the nucleus	R-HSA-205043	5.485904e-03	2.261
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	6.272979e-03	2.203
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.018742e-03	2.220
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.869858e-03	2.231
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.929203e-03	2.227
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.935160e-03	2.227
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.941473e-03	2.226
DNA Double-Strand Break Repair	R-HSA-5693532	6.421873e-03	2.192
SARS-CoV-1-host interactions	R-HSA-9692914	6.580218e-03	2.182
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	6.780504e-03	2.169
Selenocysteine synthesis	R-HSA-2408557	6.903180e-03	2.161
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	7.568407e-03	2.121
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.247380e-03	2.140
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.072065e-03	2.150
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	7.268365e-03	2.139
Protein methylation	R-HSA-8876725	7.268365e-03	2.139
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	7.772375e-03	2.109
DNA Damage Recognition in GG-NER	R-HSA-5696394	7.848451e-03	2.105
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.547661e-03	2.068
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	9.341627e-03	2.030
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.627598e-03	2.064
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	9.142258e-03	2.039
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	9.307866e-03	2.031
Neurodegenerative Diseases	R-HSA-8863678	9.142258e-03	2.039
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	9.142258e-03	2.039
Mitophagy	R-HSA-5205647	9.307866e-03	2.031
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.761266e-03	2.057
Golgi-to-ER retrograde transport	R-HSA-8856688	8.969963e-03	2.047
Negative regulation of MET activity	R-HSA-6807004	9.509546e-03	2.022
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	9.509546e-03	2.022
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	9.509546e-03	2.022
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	9.646847e-03	2.016
Downregulation of ERBB4 signaling	R-HSA-1253288	9.646847e-03	2.016
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	9.646847e-03	2.016
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	9.646847e-03	2.016
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	9.785639e-03	2.009
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.160896e-02	1.935
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.160896e-02	1.935
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.160896e-02	1.935
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.160896e-02	1.935
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.160896e-02	1.935
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.160896e-02	1.935
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.160896e-02	1.935
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.160896e-02	1.935
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.160896e-02	1.935
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.160896e-02	1.935
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.160896e-02	1.935
Repression of WNT target genes	R-HSA-4641265	1.155613e-02	1.937
Disorders of Developmental Biology	R-HSA-9675151	1.206770e-02	1.918
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.155803e-02	1.937
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.155803e-02	1.937
Signaling downstream of RAS mutants	R-HSA-9649948	1.155803e-02	1.937
Downregulation of ERBB2 signaling	R-HSA-8863795	1.024864e-02	1.989
Sema4D in semaphorin signaling	R-HSA-400685	1.112042e-02	1.954
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.024864e-02	1.989
Signaling by RAS mutants	R-HSA-6802949	1.155803e-02	1.937
VLDLR internalisation and degradation	R-HSA-8866427	1.155613e-02	1.937
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.155613e-02	1.937
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.173969e-02	1.930
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.206770e-02	1.918
p75NTR recruits signalling complexes	R-HSA-209543	1.155613e-02	1.937
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.011446e-02	1.995
Homology Directed Repair	R-HSA-5693538	1.279727e-02	1.893
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.284590e-02	1.891
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.446945e-02	1.840
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.446945e-02	1.840
MAP2K and MAPK activation	R-HSA-5674135	1.317025e-02	1.880
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.317025e-02	1.880
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.317025e-02	1.880
Oncogenic MAPK signaling	R-HSA-6802957	1.377758e-02	1.861
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.309612e-02	1.883
Signaling by RAF1 mutants	R-HSA-9656223	1.317025e-02	1.880
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.358770e-02	1.867
TCF dependent signaling in response to WNT	R-HSA-201681	1.346146e-02	1.871
Cellular response to chemical stress	R-HSA-9711123	1.314826e-02	1.881
G alpha (12/13) signalling events	R-HSA-416482	1.302776e-02	1.885
Oxidative Stress Induced Senescence	R-HSA-2559580	1.411472e-02	1.850
Adherens junctions interactions	R-HSA-418990	1.372974e-02	1.862
Clathrin-mediated endocytosis	R-HSA-8856828	1.450423e-02	1.839
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.453958e-02	1.837
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.457585e-02	1.836
Maturation of protein E	R-HSA-9694493	1.457585e-02	1.836
Maturation of protein E	R-HSA-9683683	1.457585e-02	1.836
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.489684e-02	1.827
Ovarian tumor domain proteases	R-HSA-5689896	1.495798e-02	1.825
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.512035e-02	1.820
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.512346e-02	1.820
Viral mRNA Translation	R-HSA-192823	1.542497e-02	1.812
DNA Double Strand Break Response	R-HSA-5693606	1.575252e-02	1.803
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.601487e-02	1.795
Vesicle-mediated transport	R-HSA-5653656	1.615719e-02	1.792
G2/M Transition	R-HSA-69275	1.635626e-02	1.786
G2/M Checkpoints	R-HSA-69481	1.652632e-02	1.782
Regulation of MECP2 expression and activity	R-HSA-9022692	1.690863e-02	1.772
Processing of DNA double-strand break ends	R-HSA-5693607	1.767979e-02	1.753
EPH-Ephrin signaling	R-HSA-2682334	1.738712e-02	1.760
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.828621e-02	1.738
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.938990e-02	1.712
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.938990e-02	1.712
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.747198e-02	1.758
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.755440e-02	1.756
Pexophagy	R-HSA-9664873	1.848906e-02	1.733
Mitotic G2-G2/M phases	R-HSA-453274	1.855009e-02	1.732
Regulation of TP53 Activity	R-HSA-5633007	1.792597e-02	1.747
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.948709e-02	1.710
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.983513e-02	1.703
Plasma lipoprotein clearance	R-HSA-8964043	1.995164e-02	1.700
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.021493e-02	1.694
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.041562e-02	1.690
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.041562e-02	1.690
Apoptosis	R-HSA-109581	2.048610e-02	1.689
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.084623e-02	1.681
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.108499e-02	1.676
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.165665e-02	1.664
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.232797e-02	1.651
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.283204e-02	1.641
Diseases of Telomere Maintenance	R-HSA-9673013	2.283204e-02	1.641
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.283204e-02	1.641
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.283204e-02	1.641
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.283204e-02	1.641
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.283204e-02	1.641
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.440983e-02	1.612
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.440983e-02	1.612
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.472713e-02	1.607
RNA Polymerase I Transcription	R-HSA-73864	2.496092e-02	1.603
Translesion Synthesis by POLH	R-HSA-110320	2.302505e-02	1.638
Translesion synthesis by REV1	R-HSA-110312	2.440983e-02	1.612
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.371372e-02	1.625
p75NTR signals via NF-kB	R-HSA-193639	2.440983e-02	1.612
Hedgehog 'on' state	R-HSA-5632684	2.395693e-02	1.621
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.614722e-02	1.583
Spry regulation of FGF signaling	R-HSA-1295596	2.440983e-02	1.612
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.443094e-02	1.612
MITF-M-regulated melanocyte development	R-HSA-9730414	2.387571e-02	1.622
AURKA Activation by TPX2	R-HSA-8854518	2.793443e-02	1.554
RUNX3 regulates WNT signaling	R-HSA-8951430	2.980538e-02	1.526
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.980538e-02	1.526
Recycling of eIF2:GDP	R-HSA-72731	2.980538e-02	1.526
Cohesin Loading onto Chromatin	R-HSA-2470946	2.980538e-02	1.526
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.147781e-02	1.502
Translesion synthesis by POLI	R-HSA-5656121	3.023064e-02	1.520
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.023064e-02	1.520
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.330210e-02	1.478
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.330210e-02	1.478
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	3.024884e-02	1.519
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.330210e-02	1.478
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.960738e-02	1.529
HDMs demethylate histones	R-HSA-3214842	2.959973e-02	1.529
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.943099e-02	1.531
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.943099e-02	1.531
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.943099e-02	1.531
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.943099e-02	1.531
NF-kB is activated and signals survival	R-HSA-209560	3.147781e-02	1.502
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.147781e-02	1.502
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	3.330210e-02	1.478
Evasion by RSV of host interferon responses	R-HSA-9833109	3.024884e-02	1.519
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.980538e-02	1.526
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.943099e-02	1.531
Assembly of the pre-replicative complex	R-HSA-68867	3.392253e-02	1.470
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	3.023064e-02	1.520
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	3.463652e-02	1.460
Regulation of PTEN gene transcription	R-HSA-8943724	2.943099e-02	1.531
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.437722e-02	1.464
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.397458e-02	1.469
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.073213e-02	1.512
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.024884e-02	1.519
Negative regulation of FLT3	R-HSA-9706369	3.023064e-02	1.520
ISG15 antiviral mechanism	R-HSA-1169408	3.502390e-02	1.456
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.689192e-02	1.433
Translesion synthesis by POLK	R-HSA-5655862	3.689192e-02	1.433
Hedgehog 'off' state	R-HSA-5610787	3.696759e-02	1.432
RNA Polymerase I Promoter Clearance	R-HSA-73854	3.829352e-02	1.417
Cellular response to starvation	R-HSA-9711097	3.917880e-02	1.407
Signaling by VEGF	R-HSA-194138	3.922298e-02	1.406
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	3.943051e-02	1.404
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.967757e-02	1.401
Disorders of Nervous System Development	R-HSA-9697154	3.967757e-02	1.401
Pervasive developmental disorders	R-HSA-9005895	3.967757e-02	1.401
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.967757e-02	1.401
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.967757e-02	1.401
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.994469e-02	1.399
ROBO receptors bind AKAP5	R-HSA-9010642	3.996221e-02	1.398
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.996221e-02	1.398
Modulation by Mtb of host immune system	R-HSA-9637628	3.996221e-02	1.398
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.022352e-02	1.396
Signaling by Hedgehog	R-HSA-5358351	4.094174e-02	1.388
RMTs methylate histone arginines	R-HSA-3214858	4.221601e-02	1.375
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	4.237302e-02	1.373
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	4.766358e-02	1.322
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.843168e-02	1.315
ALK mutants bind TKIs	R-HSA-9700645	5.185310e-02	1.285
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	4.442485e-02	1.352
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.285178e-02	1.277
Dual Incision in GG-NER	R-HSA-5696400	5.155319e-02	1.288
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	5.243028e-02	1.280
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	4.945596e-02	1.306
mRNA 3'-end processing	R-HSA-72187	4.945596e-02	1.306
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	5.312557e-02	1.275
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.947809e-02	1.306
Deubiquitination	R-HSA-5688426	4.440560e-02	1.353
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.843168e-02	1.315
Unwinding of DNA	R-HSA-176974	5.185310e-02	1.285
Membrane binding and targetting of GAG proteins	R-HSA-174490	4.906121e-02	1.309
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.358145e-02	1.271
Signaling by NOTCH	R-HSA-157118	4.459303e-02	1.351
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	5.185310e-02	1.285
Switching of origins to a post-replicative state	R-HSA-69052	5.312557e-02	1.275
Neurexins and neuroligins	R-HSA-6794361	4.945596e-02	1.306
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.627364e-02	1.335
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.625186e-02	1.335
Signaling by Hippo	R-HSA-2028269	4.442485e-02	1.352
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.028369e-02	1.299
Cell-cell junction organization	R-HSA-421270	5.218878e-02	1.282
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.713516e-02	1.327
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.713516e-02	1.327
Transcriptional regulation by RUNX1	R-HSA-8878171	4.686685e-02	1.329
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.880463e-02	1.312
Programmed Cell Death	R-HSA-5357801	5.043914e-02	1.297
SARS-CoV-1 Infection	R-HSA-9678108	4.731932e-02	1.325
XBP1(S) activates chaperone genes	R-HSA-381038	5.376983e-02	1.269
Co-inhibition by PD-1	R-HSA-389948	5.429858e-02	1.265
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	5.457831e-02	1.263
FLT3 Signaling	R-HSA-9607240	5.535830e-02	1.257
Signaling by ERBB2	R-HSA-1227986	5.609117e-02	1.251
HIV Life Cycle	R-HSA-162587	5.622245e-02	1.250
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.709928e-02	1.243
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.811022e-02	1.236
Influenza Infection	R-HSA-168255	5.839535e-02	1.234
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.964293e-02	1.224
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.964293e-02	1.224
RNA Polymerase II Transcription Termination	R-HSA-73856	6.134559e-02	1.212
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	6.204119e-02	1.207
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	6.214367e-02	1.207
Diseases of programmed cell death	R-HSA-9645723	6.246150e-02	1.204
Centrosome maturation	R-HSA-380287	6.254476e-02	1.204
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.418242e-02	1.193
NGF-stimulated transcription	R-HSA-9031628	6.418242e-02	1.193
PRC2 methylates histones and DNA	R-HSA-212300	6.517638e-02	1.186
Folding of actin by CCT/TriC	R-HSA-390450	6.546126e-02	1.184
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	6.546126e-02	1.184
Apoptosis induced DNA fragmentation	R-HSA-140342	6.546126e-02	1.184
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.586646e-02	1.181
HDACs deacetylate histones	R-HSA-3214815	6.586646e-02	1.181
Noncanonical activation of NOTCH3	R-HSA-9017802	6.657746e-02	1.177
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.657746e-02	1.177
PTEN Regulation	R-HSA-6807070	6.697429e-02	1.174
Mitotic Prophase	R-HSA-68875	6.706531e-02	1.174
UCH proteinases	R-HSA-5689603	6.765261e-02	1.170
EGFR downregulation	R-HSA-182971	6.840546e-02	1.165
RNA Polymerase I Transcription Initiation	R-HSA-73762	6.845138e-02	1.165
HIV Infection	R-HSA-162906	6.942059e-02	1.159
DNA Damage Bypass	R-HSA-73893	7.065287e-02	1.151
Interleukin-7 signaling	R-HSA-1266695	7.102946e-02	1.149
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.142072e-02	1.146
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	7.142072e-02	1.146
IRF3-mediated induction of type I IFN	R-HSA-3270619	7.142072e-02	1.146
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	7.142072e-02	1.146
DCC mediated attractive signaling	R-HSA-418885	7.142072e-02	1.146
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.204381e-02	1.142
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.204381e-02	1.142
Protein hydroxylation	R-HSA-9629569	7.243232e-02	1.140
Nephrin family interactions	R-HSA-373753	7.243232e-02	1.140
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.310916e-02	1.136
DNA Replication Pre-Initiation	R-HSA-69002	7.386666e-02	1.132
PECAM1 interactions	R-HSA-210990	8.073798e-02	1.093
Activation of RAC1	R-HSA-428540	9.760735e-02	1.011
Condensation of Prometaphase Chromosomes	R-HSA-2514853	9.760735e-02	1.011
Signaling by GSK3beta mutants	R-HSA-5339716	9.760735e-02	1.011
Activation of SMO	R-HSA-5635838	8.437733e-02	1.074
Processing of Intronless Pre-mRNAs	R-HSA-77595	9.848142e-02	1.007
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	9.848142e-02	1.007
Signaling by EGFR in Cancer	R-HSA-1643713	8.075109e-02	1.093
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.120248e-02	1.040
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	8.612989e-02	1.065
Regulation of RAS by GAPs	R-HSA-5658442	7.752611e-02	1.111
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.249124e-02	1.034
Myogenesis	R-HSA-525793	8.075109e-02	1.093
RNA Polymerase II Pre-transcription Events	R-HSA-674695	9.863699e-02	1.006
Orc1 removal from chromatin	R-HSA-68949	9.249124e-02	1.034
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.526772e-02	1.069
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	9.848142e-02	1.007
Fanconi Anemia Pathway	R-HSA-6783310	9.150123e-02	1.039
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	7.903790e-02	1.102
G2/M DNA damage checkpoint	R-HSA-69473	9.863699e-02	1.006
Cilium Assembly	R-HSA-5617833	9.816008e-02	1.008
Protein-protein interactions at synapses	R-HSA-6794362	7.805787e-02	1.108
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	7.867854e-02	1.104
L1CAM interactions	R-HSA-373760	8.177524e-02	1.087
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	7.696157e-02	1.114
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.567671e-02	1.121
MAPK6/MAPK4 signaling	R-HSA-5687128	7.805787e-02	1.108
Sensory processing of sound	R-HSA-9659379	8.461370e-02	1.073
Basigin interactions	R-HSA-210991	8.358610e-02	1.078
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	9.848142e-02	1.007
Regulation of BACH1 activity	R-HSA-9708530	8.437733e-02	1.074
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	9.563473e-02	1.019
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	9.563473e-02	1.019
MITF-M-dependent gene expression	R-HSA-9856651	8.533224e-02	1.069
IRE1alpha activates chaperones	R-HSA-381070	8.261100e-02	1.083
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.005844e-01	0.997
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.005844e-01	0.997
Synthesis of DNA	R-HSA-69239	1.018040e-01	0.992
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.057775e-01	0.976
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.083516e-01	0.965
Hh mutants are degraded by ERAD	R-HSA-5362768	1.083516e-01	0.965
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.083516e-01	0.965
mTORC1-mediated signalling	R-HSA-166208	1.085576e-01	0.964
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.089224e-01	0.963
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.090827e-01	0.962
Recycling pathway of L1	R-HSA-437239	1.091557e-01	0.962
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	1.091557e-01	0.962
Disinhibition of SNARE formation	R-HSA-114516	1.104707e-01	0.957
Nef Mediated CD4 Down-regulation	R-HSA-167590	1.104707e-01	0.957
Uptake and function of diphtheria toxin	R-HSA-5336415	1.104707e-01	0.957
S Phase	R-HSA-69242	1.120419e-01	0.951
Regulation of FZD by ubiquitination	R-HSA-4641263	1.136890e-01	0.944
Axonal growth stimulation	R-HSA-209563	1.142367e-01	0.942
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.142367e-01	0.942
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.142367e-01	0.942
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.142367e-01	0.942
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	1.142367e-01	0.942
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.142367e-01	0.942
Termination of translesion DNA synthesis	R-HSA-5656169	1.142537e-01	0.942
DARPP-32 events	R-HSA-180024	1.142537e-01	0.942
Selenoamino acid metabolism	R-HSA-2408522	1.156347e-01	0.937
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.159710e-01	0.936
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.159710e-01	0.936
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.159710e-01	0.936
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.159710e-01	0.936
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.159710e-01	0.936
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.159710e-01	0.936
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.159710e-01	0.936
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.159710e-01	0.936
IRAK1 recruits IKK complex	R-HSA-937039	1.159710e-01	0.936
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.167490e-01	0.933
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.167490e-01	0.933
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.172645e-01	0.931
Regulation of T cell activation by CD28 family	R-HSA-388841	1.184014e-01	0.927
MHC class II antigen presentation	R-HSA-2132295	1.199148e-01	0.921
Late Phase of HIV Life Cycle	R-HSA-162599	1.209939e-01	0.917
DNA Repair	R-HSA-73894	1.217528e-01	0.915
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.223267e-01	0.912
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.237098e-01	0.908
G1/S DNA Damage Checkpoints	R-HSA-69615	1.254703e-01	0.901
Meiosis	R-HSA-1500620	1.260557e-01	0.899
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.270901e-01	0.896
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.272803e-01	0.895
Signaling by WNT	R-HSA-195721	1.286801e-01	0.890
HSF1 activation	R-HSA-3371511	1.288202e-01	0.890
Vif-mediated degradation of APOBEC3G	R-HSA-180585	1.288202e-01	0.890
FLT3 signaling in disease	R-HSA-9682385	1.288202e-01	0.890
Ephrin signaling	R-HSA-3928664	1.299451e-01	0.886
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.529816e-01	0.815
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.529816e-01	0.815
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	1.529816e-01	0.815
IRS activation	R-HSA-74713	1.937979e-01	0.713
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.937979e-01	0.713
Formation of annular gap junctions	R-HSA-196025	1.356443e-01	0.868
Gap junction degradation	R-HSA-190873	1.625558e-01	0.789
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.357128e-01	0.867
PI3K/AKT activation	R-HSA-198203	1.908920e-01	0.719
MET activates RAP1 and RAC1	R-HSA-8875555	1.908920e-01	0.719
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.908920e-01	0.719
Beta-catenin phosphorylation cascade	R-HSA-196299	1.788032e-01	0.748
Regulation of signaling by CBL	R-HSA-912631	1.471849e-01	0.832
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.471849e-01	0.832
Phosphorylation of the APC/C	R-HSA-176412	2.018680e-01	0.695
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.018680e-01	0.695
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.400518e-01	0.854
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.683347e-01	0.774
Interaction between L1 and Ankyrins	R-HSA-445095	1.850849e-01	0.733
RNA Polymerase I Promoter Opening	R-HSA-73728	1.850849e-01	0.733
G-protein beta:gamma signalling	R-HSA-397795	1.683940e-01	0.774
Telomere Extension By Telomerase	R-HSA-171319	2.024551e-01	0.694
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.024551e-01	0.694
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.804748e-01	0.744
RNA Polymerase I Promoter Escape	R-HSA-73772	1.610219e-01	0.793
Formation of RNA Pol II elongation complex	R-HSA-112382	1.610219e-01	0.793
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.726403e-01	0.763
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.897518e-01	0.722
Protein ubiquitination	R-HSA-8852135	1.691300e-01	0.772
Chaperonin-mediated protein folding	R-HSA-390466	1.505015e-01	0.822
PKR-mediated signaling	R-HSA-9833482	1.459816e-01	0.836
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.642035e-01	0.785
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	1.946288e-01	0.711
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.005038e-01	0.698
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.369073e-01	0.864
Nucleotide Excision Repair	R-HSA-5696398	1.378352e-01	0.861
EPHB-mediated forward signaling	R-HSA-3928662	1.520820e-01	0.818
Resolution of D-Loop Structures	R-HSA-5693537	1.834387e-01	0.737
Metalloprotease DUBs	R-HSA-5689901	1.683347e-01	0.774
COPI-mediated anterograde transport	R-HSA-6807878	1.804676e-01	0.744
Generation of second messenger molecules	R-HSA-202433	1.804748e-01	0.744
Diseases of mitotic cell cycle	R-HSA-9675126	1.539201e-01	0.813
HATs acetylate histones	R-HSA-3214847	1.419579e-01	0.848
p75NTR regulates axonogenesis	R-HSA-193697	1.625558e-01	0.789
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.409399e-01	0.851
Circadian clock	R-HSA-9909396	1.982577e-01	0.703
Rap1 signalling	R-HSA-392517	1.471849e-01	0.832
Degradation of DVL	R-HSA-4641258	1.409399e-01	0.851
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.400518e-01	0.854
Adrenoceptors	R-HSA-390696	1.356443e-01	0.868
Axonal growth inhibition (RHOA activation)	R-HSA-193634	1.356443e-01	0.868
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.357128e-01	0.867
DNA strand elongation	R-HSA-69190	1.539201e-01	0.813
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.946288e-01	0.711
Regulation of PTEN stability and activity	R-HSA-8948751	1.726403e-01	0.763
Regulation of TNFR1 signaling	R-HSA-5357905	1.767669e-01	0.753
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.742577e-01	0.759
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.833089e-01	0.737
Hh mutants abrogate ligand secretion	R-HSA-5387390	1.404208e-01	0.853
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.667908e-01	0.778
DAG and IP3 signaling	R-HSA-1489509	1.642035e-01	0.785
Estrogen-dependent gene expression	R-HSA-9018519	1.762340e-01	0.754
MTF1 activates gene expression	R-HSA-5660489	1.529816e-01	0.815
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	1.937979e-01	0.713
Sodium/Proton exchangers	R-HSA-425986	1.356443e-01	0.868
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.024551e-01	0.694
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.990168e-01	0.701
DNA Replication	R-HSA-69306	1.930428e-01	0.714
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.625558e-01	0.789
STING mediated induction of host immune responses	R-HSA-1834941	1.471849e-01	0.832
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.794466e-01	0.746
Vpu mediated degradation of CD4	R-HSA-180534	1.834387e-01	0.737
Stabilization of p53	R-HSA-69541	1.667908e-01	0.778
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	1.990168e-01	0.701
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.990168e-01	0.701
Signal transduction by L1	R-HSA-445144	1.653359e-01	0.782
Cellular response to mitochondrial stress	R-HSA-9840373	1.625558e-01	0.789
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.804748e-01	0.744
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.804748e-01	0.744
Transcriptional Regulation by VENTX	R-HSA-8853884	1.946288e-01	0.711
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.642035e-01	0.785
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.409399e-01	0.851
Transcriptional Regulation by TP53	R-HSA-3700989	1.892139e-01	0.723
ER Quality Control Compartment (ERQC)	R-HSA-901032	1.850849e-01	0.733
Regulation of NF-kappa B signaling	R-HSA-9758274	2.018680e-01	0.695
Unfolded Protein Response (UPR)	R-HSA-381119	1.432566e-01	0.844
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.027592e-01	0.693
Signaling by PTK6	R-HSA-8848021	2.027592e-01	0.693
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.040508e-01	0.690
Assembly Of The HIV Virion	R-HSA-175474	2.040508e-01	0.690
Signaling by PDGFR in disease	R-HSA-9671555	2.040508e-01	0.690
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.059863e-01	0.686
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	2.059863e-01	0.686
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.059863e-01	0.686
Blockage of phagosome acidification	R-HSA-9636467	2.059863e-01	0.686
TICAM1 deficiency - HSE	R-HSA-5602566	2.059863e-01	0.686
Formation of editosomes by ADAR proteins	R-HSA-77042	2.059863e-01	0.686
Inhibition of PKR	R-HSA-169131	2.059863e-01	0.686
Protein folding	R-HSA-391251	2.063191e-01	0.685
Regulation of mitotic cell cycle	R-HSA-453276	2.073589e-01	0.683
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.073589e-01	0.683
NoRC negatively regulates rRNA expression	R-HSA-427413	2.073589e-01	0.683
Degradation of CRY and PER proteins	R-HSA-9932298	2.092237e-01	0.679
Negative regulation of MAPK pathway	R-HSA-5675221	2.092237e-01	0.679
Signaling by EGFR	R-HSA-177929	2.097224e-01	0.678
TNF signaling	R-HSA-75893	2.097224e-01	0.678
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	2.150880e-01	0.667
Regulation of Apoptosis	R-HSA-169911	2.150880e-01	0.667
Degradation of CDH1	R-HSA-9766229	2.168965e-01	0.664
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.168965e-01	0.664
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.168965e-01	0.664
Signaling by APC mutants	R-HSA-4839744	2.203472e-01	0.657
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.203472e-01	0.657
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.203472e-01	0.657
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.203472e-01	0.657
ChREBP activates metabolic gene expression	R-HSA-163765	2.203472e-01	0.657
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.203879e-01	0.657
Chromosome Maintenance	R-HSA-73886	2.220353e-01	0.654
Cellular response to heat stress	R-HSA-3371556	2.220353e-01	0.654
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.221956e-01	0.653
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.221956e-01	0.653
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.227249e-01	0.652
Nuclear Envelope Breakdown	R-HSA-2980766	2.227646e-01	0.652
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.242284e-01	0.649
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.242284e-01	0.649
Interactions of Tat with host cellular proteins	R-HSA-176034	2.924823e-01	0.534
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.924823e-01	0.534
TRAF3 deficiency - HSE	R-HSA-5602571	2.924823e-01	0.534
Signaling by TCF7L2 mutants	R-HSA-5339700	2.924823e-01	0.534
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.924823e-01	0.534
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.924823e-01	0.534
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.357754e-01	0.628
Nef Mediated CD8 Down-regulation	R-HSA-182218	2.357754e-01	0.628
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.695603e-01	0.432
Chylomicron clearance	R-HSA-8964026	2.781774e-01	0.556
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.781774e-01	0.556
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	2.506303e-01	0.601
MECP2 regulates transcription factors	R-HSA-9022707	3.204137e-01	0.494
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.204137e-01	0.494
NOSTRIN mediated eNOS trafficking	R-HSA-203641	3.204137e-01	0.494
SOS-mediated signalling	R-HSA-112412	3.204137e-01	0.494
MET interacts with TNS proteins	R-HSA-8875513	4.382454e-01	0.358
Defective MMACHC causes MAHCC	R-HSA-3359474	4.382454e-01	0.358
MET activates PTPN11	R-HSA-8865999	4.382454e-01	0.358
Defective DPM3 causes DPM3-CDG	R-HSA-4719360	4.382454e-01	0.358
Defective DPM1 causes DPM1-CDG	R-HSA-4717374	4.382454e-01	0.358
Defective DPM2 causes DPM2-CDG	R-HSA-4719377	4.382454e-01	0.358
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	4.382454e-01	0.358
Defective GCLC causes HAGGSD	R-HSA-5578999	4.382454e-01	0.358
Invadopodia formation	R-HSA-8941237	4.382454e-01	0.358
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.814690e-01	0.551
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	2.503026e-01	0.602
Type I hemidesmosome assembly	R-HSA-446107	3.620175e-01	0.441
Notch-HLH transcription pathway	R-HSA-350054	2.244437e-01	0.649
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.753803e-01	0.560
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	2.454087e-01	0.610
Deadenylation of mRNA	R-HSA-429947	2.668557e-01	0.574
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.008428e-01	0.522
Lipophagy	R-HSA-9613354	4.026256e-01	0.395
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.026256e-01	0.395
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	2.886951e-01	0.540
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.265559e-01	0.486
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.265559e-01	0.486
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.265559e-01	0.486
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.265559e-01	0.486
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.265559e-01	0.486
ERBB2 Regulates Cell Motility	R-HSA-6785631	3.749243e-01	0.426
Integrin signaling	R-HSA-354192	2.965358e-01	0.528
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	4.419614e-01	0.355
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	4.419614e-01	0.355
2-LTR circle formation	R-HSA-164843	4.419614e-01	0.355
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.331991e-01	0.477
EPHA-mediated growth cone collapse	R-HSA-3928663	3.331991e-01	0.477
Packaging Of Telomere Ends	R-HSA-171306	3.331991e-01	0.477
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	2.601774e-01	0.585
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.163676e-01	0.500
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	4.057087e-01	0.392
Meiotic synapsis	R-HSA-1221632	2.751809e-01	0.560
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.363943e-01	0.473
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.451743e-01	0.611
DNA methylation	R-HSA-5334118	3.782434e-01	0.422
Impaired BRCA2 binding to RAD51	R-HSA-9709570	3.782434e-01	0.422
TRAF3-dependent IRF activation pathway	R-HSA-918233	4.360279e-01	0.360
G beta:gamma signalling through CDC42	R-HSA-8964616	4.360279e-01	0.360
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.215230e-01	0.493
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.208402e-01	0.494
Nucleosome assembly	R-HSA-774815	4.117050e-01	0.385
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.117050e-01	0.385
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.374243e-01	0.359
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.374243e-01	0.359
Condensation of Prophase Chromosomes	R-HSA-2299718	4.302144e-01	0.366
Transcriptional Regulation by MECP2	R-HSA-8986944	2.697100e-01	0.569
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.013177e-01	0.521
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.013177e-01	0.521
Signaling by MET	R-HSA-6806834	4.355417e-01	0.361
Telomere Maintenance	R-HSA-157579	3.670240e-01	0.435
Extension of Telomeres	R-HSA-180786	3.692495e-01	0.433
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.265559e-01	0.486
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.553351e-01	0.593
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.965358e-01	0.528
EGFR Transactivation by Gastrin	R-HSA-2179392	4.419614e-01	0.355
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	3.633889e-01	0.440
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.485397e-01	0.605
Regulation of CDH11 function	R-HSA-9762292	4.419614e-01	0.355
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	2.713685e-01	0.566
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.506303e-01	0.601
PKA activation	R-HSA-163615	2.753803e-01	0.560
Telomere C-strand synthesis initiation	R-HSA-174430	3.749243e-01	0.426
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	3.749243e-01	0.426
RNA Polymerase I Transcription Termination	R-HSA-73863	3.331991e-01	0.477
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	4.360279e-01	0.360
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	4.294923e-01	0.367
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	3.720383e-01	0.429
TCR signaling	R-HSA-202403	2.494456e-01	0.603
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.701271e-01	0.568
Activation of HOX genes during differentiation	R-HSA-5619507	2.701271e-01	0.568
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.506303e-01	0.601
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.523921e-01	0.453
Cellular response to hypoxia	R-HSA-1234174	2.273016e-01	0.643
Meiotic recombination	R-HSA-912446	3.720383e-01	0.429
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.357754e-01	0.628
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	2.503026e-01	0.602
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.503026e-01	0.602
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	3.438320e-01	0.464
GP1b-IX-V activation signalling	R-HSA-430116	4.026256e-01	0.395
Calcineurin activates NFAT	R-HSA-2025928	4.026256e-01	0.395
Activation of ATR in response to replication stress	R-HSA-176187	2.965358e-01	0.528
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.419614e-01	0.355
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	4.007711e-01	0.397
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.374243e-01	0.359
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.753803e-01	0.560
Signaling by WNT in cancer	R-HSA-4791275	4.454805e-01	0.351
MTOR signalling	R-HSA-165159	3.561123e-01	0.448
Regulation of beta-cell development	R-HSA-186712	2.497499e-01	0.602
NOD1/2 Signaling Pathway	R-HSA-168638	3.363943e-01	0.473
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	2.357754e-01	0.628
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.357754e-01	0.628
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	2.454087e-01	0.610
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	3.749243e-01	0.426
Nuclear RNA decay	R-HSA-9930044	2.965358e-01	0.528
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	2.713685e-01	0.566
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.039662e-01	0.394
Activation of NF-kappaB in B cells	R-HSA-1169091	3.720383e-01	0.429
Heme signaling	R-HSA-9707616	4.175807e-01	0.379
Regulation of insulin secretion	R-HSA-422356	2.813126e-01	0.551
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.423632e-01	0.354
Asymmetric localization of PCP proteins	R-HSA-4608870	2.713685e-01	0.566
Acetylcholine regulates insulin secretion	R-HSA-399997	4.360279e-01	0.360
TBC/RABGAPs	R-HSA-8854214	3.746127e-01	0.426
Calmodulin induced events	R-HSA-111933	2.316102e-01	0.635
PLC beta mediated events	R-HSA-112043	4.014500e-01	0.396
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	3.438320e-01	0.464
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.363943e-01	0.473
ESR-mediated signaling	R-HSA-8939211	2.326631e-01	0.633
RAF/MAP kinase cascade	R-HSA-5673001	4.313225e-01	0.365
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.140032e-01	0.383
CaM pathway	R-HSA-111997	2.316102e-01	0.635
Frs2-mediated activation	R-HSA-170968	3.126122e-01	0.505
ER to Golgi Anterograde Transport	R-HSA-199977	4.419400e-01	0.355
Host Interactions of HIV factors	R-HSA-162909	2.498271e-01	0.602
Organelle biogenesis and maintenance	R-HSA-1852241	2.400341e-01	0.620
Polo-like kinase mediated events	R-HSA-156711	2.753803e-01	0.560
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.119271e-01	0.385
Prolonged ERK activation events	R-HSA-169893	4.057087e-01	0.392
Regulation of necroptotic cell death	R-HSA-5675482	2.965358e-01	0.528
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.208402e-01	0.494
Cargo trafficking to the periciliary membrane	R-HSA-5620920	4.271553e-01	0.369
Post NMDA receptor activation events	R-HSA-438064	3.187612e-01	0.497
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.924823e-01	0.534
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.924823e-01	0.534
Manipulation of host energy metabolism	R-HSA-9636667	2.924823e-01	0.534
mRNA Editing: A to I Conversion	R-HSA-75064	3.695603e-01	0.432
Regulation of cortical dendrite branching	R-HSA-8985801	3.695603e-01	0.432
C6 deamination of adenosine	R-HSA-75102	3.695603e-01	0.432
Signaling by AMER1 mutants	R-HSA-4839748	2.506303e-01	0.601
Signaling by AXIN mutants	R-HSA-4839735	2.506303e-01	0.601
MET activates STAT3	R-HSA-8875791	4.382454e-01	0.358
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.382454e-01	0.358
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	2.814690e-01	0.551
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.503026e-01	0.602
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	3.126122e-01	0.505
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.753803e-01	0.560
PKA activation in glucagon signalling	R-HSA-164378	2.753803e-01	0.560
Regulation of KIT signaling	R-HSA-1433559	3.438320e-01	0.464
ARMS-mediated activation	R-HSA-170984	4.026256e-01	0.395
WNT mediated activation of DVL	R-HSA-201688	4.026256e-01	0.395
Degradation of AXIN	R-HSA-4641257	2.485397e-01	0.605
Defective CFTR causes cystic fibrosis	R-HSA-5678895	2.713685e-01	0.566
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	4.057087e-01	0.392
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.363943e-01	0.473
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.363943e-01	0.473
Cyclin E associated events during G1/S transition	R-HSA-69202	4.119271e-01	0.385
MAPK family signaling cascades	R-HSA-5683057	3.040733e-01	0.517
Early Phase of HIV Life Cycle	R-HSA-162594	3.523921e-01	0.453
Ca-dependent events	R-HSA-111996	3.561123e-01	0.448
Interferon Signaling	R-HSA-913531	3.801722e-01	0.420
Negative regulation of FGFR1 signaling	R-HSA-5654726	2.965358e-01	0.528
Intracellular signaling by second messengers	R-HSA-9006925	3.258757e-01	0.487
Gene expression (Transcription)	R-HSA-74160	3.331561e-01	0.477
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.277046e-01	0.485
Integration of energy metabolism	R-HSA-163685	4.043123e-01	0.393
Beta-catenin independent WNT signaling	R-HSA-3858494	3.173016e-01	0.499
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.749243e-01	0.426
Signal attenuation	R-HSA-74749	4.419614e-01	0.355
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.331991e-01	0.477
Gap junction trafficking and regulation	R-HSA-157858	3.378706e-01	0.471
RIPK1-mediated regulated necrosis	R-HSA-5213460	4.172812e-01	0.380
Netrin-1 signaling	R-HSA-373752	3.931576e-01	0.405
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	4.486470e-01	0.348
Reproduction	R-HSA-1474165	2.497378e-01	0.603
MAP kinase activation	R-HSA-450294	2.777891e-01	0.556
RNA Polymerase II Transcription	R-HSA-73857	4.150797e-01	0.382
Nef and signal transduction	R-HSA-164944	2.781774e-01	0.556
CHL1 interactions	R-HSA-447041	3.204137e-01	0.494
Formation of intermediate mesoderm	R-HSA-9761174	4.419614e-01	0.355
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.172812e-01	0.380
Muscle contraction	R-HSA-397014	3.565396e-01	0.448
PCP/CE pathway	R-HSA-4086400	4.066158e-01	0.391
Response of endothelial cells to shear stress	R-HSA-9860931	2.594328e-01	0.586
Interleukin-17 signaling	R-HSA-448424	4.119271e-01	0.385
Interleukin-1 signaling	R-HSA-9020702	4.176725e-01	0.379
Detoxification of Reactive Oxygen Species	R-HSA-3299685	3.215230e-01	0.493
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.935563e-01	0.532
Gap junction trafficking	R-HSA-190828	3.931576e-01	0.405
Signaling by TGFB family members	R-HSA-9006936	3.202408e-01	0.495
Breakdown of the nuclear lamina	R-HSA-352238	2.924823e-01	0.534
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.357754e-01	0.628
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.382454e-01	0.358
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	2.814690e-01	0.551
TGFBR3 PTM regulation	R-HSA-9839383	3.620175e-01	0.441
Transport of connexons to the plasma membrane	R-HSA-190872	2.753803e-01	0.560
Regulation of TP53 Degradation	R-HSA-6804757	2.316102e-01	0.635
Defective pyroptosis	R-HSA-9710421	2.396101e-01	0.620
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	2.601774e-01	0.585
Glucagon signaling in metabolic regulation	R-HSA-163359	3.163676e-01	0.500
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	4.057087e-01	0.392
Syndecan interactions	R-HSA-3000170	4.294923e-01	0.367
SARS-CoV-2-host interactions	R-HSA-9705683	2.850417e-01	0.545
Cellular responses to mechanical stimuli	R-HSA-9855142	2.910544e-01	0.536
Smooth Muscle Contraction	R-HSA-445355	2.751809e-01	0.560
Formation of definitive endoderm	R-HSA-9823730	3.265559e-01	0.486
LDL clearance	R-HSA-8964038	4.039662e-01	0.394
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.781774e-01	0.556
Histamine receptors	R-HSA-390650	4.382454e-01	0.358
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.620175e-01	0.441
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.834395e-01	0.548
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.705118e-01	0.431
Hedgehog ligand biogenesis	R-HSA-5358346	2.454437e-01	0.610
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	2.932680e-01	0.533
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.695603e-01	0.432
Interleukin-18 signaling	R-HSA-9012546	3.620175e-01	0.441
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.419614e-01	0.355
Signaling by ERBB4	R-HSA-1236394	3.491033e-01	0.457
Amyloid fiber formation	R-HSA-977225	3.333143e-01	0.477
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	4.057087e-01	0.392
HDL assembly	R-HSA-8963896	3.438320e-01	0.464
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	4.151292e-01	0.382
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.565560e-01	0.448
Signaling by TGFBR3	R-HSA-9839373	4.302144e-01	0.366
Specification of primordial germ cells	R-HSA-9827857	2.503026e-01	0.602
Diseases of DNA repair	R-HSA-9675135	4.302144e-01	0.366
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.357754e-01	0.628
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	2.257503e-01	0.646
Respiratory syncytial virus genome replication	R-HSA-9834752	4.026256e-01	0.395
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.026256e-01	0.395
Regulated proteolysis of p75NTR	R-HSA-193692	4.026256e-01	0.395
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	4.454805e-01	0.351
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	3.523921e-01	0.453
Suppression of phagosomal maturation	R-HSA-9637687	3.108383e-01	0.507
Tandem pore domain potassium channels	R-HSA-1296346	4.419614e-01	0.355
Calnexin/calreticulin cycle	R-HSA-901042	3.363943e-01	0.473
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	3.523921e-01	0.453
RET signaling	R-HSA-8853659	2.316102e-01	0.635
Interferon alpha/beta signaling	R-HSA-909733	3.236165e-01	0.490
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	3.782323e-01	0.422
Signaling by Leptin	R-HSA-2586552	4.419614e-01	0.355
Glycogen storage diseases	R-HSA-3229121	2.503026e-01	0.602
Glycogen synthesis	R-HSA-3322077	3.265559e-01	0.486
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	2.753803e-01	0.560
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	4.039662e-01	0.394
Signaling by NTRKs	R-HSA-166520	4.525006e-01	0.344
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	4.536436e-01	0.343
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.547188e-01	0.342
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	4.547188e-01	0.342
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.547188e-01	0.342
Plasma lipoprotein assembly	R-HSA-8963898	4.547188e-01	0.342
Opioid Signalling	R-HSA-111885	4.558169e-01	0.341
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.574355e-01	0.340
Attenuation phase	R-HSA-3371568	4.574355e-01	0.340
Glycogen metabolism	R-HSA-8982491	4.574355e-01	0.340
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.575289e-01	0.340
Ca2+ pathway	R-HSA-4086398	4.575289e-01	0.340
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.629019e-01	0.335
Signaling by EGFRvIII in Cancer	R-HSA-5637812	4.657466e-01	0.332
Constitutive Signaling by EGFRvIII	R-HSA-5637810	4.657466e-01	0.332
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.657466e-01	0.332
Transcriptional regulation by RUNX2	R-HSA-8878166	4.665897e-01	0.331
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.669661e-01	0.331
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.675335e-01	0.330
Assembly of the ORC complex at the origin of replication	R-HSA-68616	4.675335e-01	0.330
Neutrophil degranulation	R-HSA-6798695	4.709245e-01	0.327
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.772696e-01	0.321
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.772696e-01	0.321
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.795631e-01	0.319
TGFBR3 expression	R-HSA-9839394	4.795631e-01	0.319
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.798203e-01	0.319
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	4.798203e-01	0.319
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	4.851368e-01	0.314
MAPK1/MAPK3 signaling	R-HSA-5684996	4.853574e-01	0.314
Iron uptake and transport	R-HSA-917937	4.876512e-01	0.312
Dual incision in TC-NER	R-HSA-6782135	4.917580e-01	0.308
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.947506e-01	0.306
G beta:gamma signalling through PLC beta	R-HSA-418217	4.947506e-01	0.306
Mismatch Repair	R-HSA-5358508	4.947506e-01	0.306
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.947506e-01	0.306
Presynaptic function of Kainate receptors	R-HSA-500657	4.947506e-01	0.306
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	4.968845e-01	0.304
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.968845e-01	0.304
G-protein mediated events	R-HSA-112040	4.974934e-01	0.303
HCN channels	R-HSA-1296061	4.994510e-01	0.302
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.994510e-01	0.302
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.994510e-01	0.302
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.994510e-01	0.302
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	4.994510e-01	0.302
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	4.994510e-01	0.302
Defective LFNG causes SCDO3	R-HSA-5083630	4.994510e-01	0.302
Signaling by MAP2K mutants	R-HSA-9652169	4.994510e-01	0.302
Regulation of gap junction activity	R-HSA-191650	4.994510e-01	0.302
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.994510e-01	0.302
Alanine metabolism	R-HSA-8964540	4.994510e-01	0.302
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.994510e-01	0.302
NADE modulates death signalling	R-HSA-205025	4.994510e-01	0.302
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.994510e-01	0.302
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	5.039522e-01	0.298
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.039522e-01	0.298
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.039522e-01	0.298
RAF activation	R-HSA-5673000	5.107522e-01	0.292
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.107522e-01	0.292
Regulated Necrosis	R-HSA-5218859	5.131596e-01	0.290
ABC-family proteins mediated transport	R-HSA-382556	5.151162e-01	0.288
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.160571e-01	0.287
Integration of provirus	R-HSA-162592	5.160571e-01	0.287
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.160571e-01	0.287
Reduction of cytosolic Ca++ levels	R-HSA-418359	5.160571e-01	0.287
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.160571e-01	0.287
Platelet activation, signaling and aggregation	R-HSA-76002	5.168272e-01	0.287
HSF1-dependent transactivation	R-HSA-3371571	5.209038e-01	0.283
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	5.211868e-01	0.283
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	5.229451e-01	0.282
O2/CO2 exchange in erythrocytes	R-HSA-1480926	5.229451e-01	0.282
Other interleukin signaling	R-HSA-449836	5.229451e-01	0.282
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	5.229451e-01	0.282
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.278217e-01	0.278
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.278217e-01	0.278
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.278217e-01	0.278
Adipogenesis	R-HSA-9843745	5.280610e-01	0.277
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.318196e-01	0.274
Oncogene Induced Senescence	R-HSA-2559585	5.318196e-01	0.274
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.351167e-01	0.272
Signaling by FGFR4	R-HSA-5654743	5.353041e-01	0.271
Response of Mtb to phagocytosis	R-HSA-9637690	5.353041e-01	0.271
Uptake and actions of bacterial toxins	R-HSA-5339562	5.384411e-01	0.269
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	5.407168e-01	0.267
Ub-specific processing proteases	R-HSA-5689880	5.408813e-01	0.267
Formation of paraxial mesoderm	R-HSA-9793380	5.413219e-01	0.267
Aquaporin-mediated transport	R-HSA-445717	5.413219e-01	0.267
PIP3 activates AKT signaling	R-HSA-1257604	5.445357e-01	0.264
Rab regulation of trafficking	R-HSA-9007101	5.457202e-01	0.263
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	5.502534e-01	0.259
Co-inhibition by CTLA4	R-HSA-389513	5.502534e-01	0.259
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	5.502534e-01	0.259
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.505760e-01	0.259
RUNX3 regulates p14-ARF	R-HSA-8951936	5.505760e-01	0.259
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.505760e-01	0.259
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.505760e-01	0.259
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	5.505760e-01	0.259
OAS antiviral response	R-HSA-8983711	5.505760e-01	0.259
HIV elongation arrest and recovery	R-HSA-167287	5.511164e-01	0.259
Pausing and recovery of HIV elongation	R-HSA-167290	5.511164e-01	0.259
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	5.511777e-01	0.259
Triglyceride catabolism	R-HSA-163560	5.524686e-01	0.258
Co-inhibition by BTLA	R-HSA-9927353	5.539911e-01	0.256
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.539911e-01	0.256
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.539911e-01	0.256
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.539911e-01	0.256
Defective F9 activation	R-HSA-9673221	5.539911e-01	0.256
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.539911e-01	0.256
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.539911e-01	0.256
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.539911e-01	0.256
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.539911e-01	0.256
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.539911e-01	0.256
Muscarinic acetylcholine receptors	R-HSA-390648	5.539911e-01	0.256
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	5.539911e-01	0.256
Inositol transporters	R-HSA-429593	5.539911e-01	0.256
NrCAM interactions	R-HSA-447038	5.539911e-01	0.256
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.539911e-01	0.256
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	5.539911e-01	0.256
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.574231e-01	0.254
Signal Transduction	R-HSA-162582	5.707681e-01	0.244
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.724217e-01	0.242
Signaling by FGFR3	R-HSA-5654741	5.724217e-01	0.242
Cleavage of the damaged purine	R-HSA-110331	5.726626e-01	0.242
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.737891e-01	0.241
Regulation of gene expression in beta cells	R-HSA-210745	5.737891e-01	0.241
Platelet calcium homeostasis	R-HSA-418360	5.737891e-01	0.241
Signaling by CSF3 (G-CSF)	R-HSA-9674555	5.737891e-01	0.241
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.749975e-01	0.240
ER-Phagosome pathway	R-HSA-1236974	5.760166e-01	0.240
TNFR1-induced proapoptotic signaling	R-HSA-5357786	5.766150e-01	0.239
Lagging Strand Synthesis	R-HSA-69186	5.766150e-01	0.239
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.793780e-01	0.237
CD28 dependent Vav1 pathway	R-HSA-389359	5.833211e-01	0.234
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.833211e-01	0.234
Reversible hydration of carbon dioxide	R-HSA-1475029	5.833211e-01	0.234
Formation of axial mesoderm	R-HSA-9796292	5.833211e-01	0.234
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.833211e-01	0.234
rRNA modification in the mitochondrion	R-HSA-6793080	5.833211e-01	0.234
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	5.833211e-01	0.234
Interleukin-1 family signaling	R-HSA-446652	5.853112e-01	0.233
Signaling by Interleukins	R-HSA-449147	5.866390e-01	0.232
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.888727e-01	0.230
Downstream TCR signaling	R-HSA-202424	5.893105e-01	0.230
mRNA Splicing - Minor Pathway	R-HSA-72165	5.904212e-01	0.229
Regulation of pyruvate metabolism	R-HSA-9861718	5.904212e-01	0.229
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	5.904468e-01	0.229
Depurination	R-HSA-73927	5.923697e-01	0.227
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.958007e-01	0.225
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.958007e-01	0.225
Activation of the pre-replicative complex	R-HSA-68962	5.958007e-01	0.225
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.958007e-01	0.225
Cytokine Signaling in Immune system	R-HSA-1280215	5.961442e-01	0.225
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.019843e-01	0.220
Glutathione synthesis and recycling	R-HSA-174403	6.019843e-01	0.220
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.023785e-01	0.220
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.023785e-01	0.220
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.023785e-01	0.220
TRAIL signaling	R-HSA-75158	6.025914e-01	0.220
PKB-mediated events	R-HSA-109703	6.025914e-01	0.220
IkBA variant leads to EDA-ID	R-HSA-5603029	6.025914e-01	0.220
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.025914e-01	0.220
PDE3B signalling	R-HSA-165160	6.025914e-01	0.220
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.025914e-01	0.220
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.025914e-01	0.220
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.025914e-01	0.220
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.025914e-01	0.220
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.025914e-01	0.220
Synthesis of dolichyl-phosphate mannose	R-HSA-162699	6.025914e-01	0.220
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.025914e-01	0.220
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.025914e-01	0.220
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.025914e-01	0.220
Signalling to p38 via RIT and RIN	R-HSA-187706	6.025914e-01	0.220
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	6.025914e-01	0.220
Sodium-coupled phosphate cotransporters	R-HSA-427652	6.025914e-01	0.220
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.026753e-01	0.220
Ion homeostasis	R-HSA-5578775	6.056980e-01	0.218
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	6.115628e-01	0.214
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.142678e-01	0.212
Retrograde neurotrophin signalling	R-HSA-177504	6.142692e-01	0.212
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.142692e-01	0.212
CRMPs in Sema3A signaling	R-HSA-399956	6.142692e-01	0.212
cGMP effects	R-HSA-418457	6.142692e-01	0.212
Signal regulatory protein family interactions	R-HSA-391160	6.142692e-01	0.212
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	6.142692e-01	0.212
SARS-CoV-2 Infection	R-HSA-9694516	6.163891e-01	0.210
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.216860e-01	0.206
GPER1 signaling	R-HSA-9634597	6.251865e-01	0.204
Intraflagellar transport	R-HSA-5620924	6.251865e-01	0.204
Gluconeogenesis	R-HSA-70263	6.251865e-01	0.204
Antigen processing-Cross presentation	R-HSA-1236975	6.261505e-01	0.203
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.261505e-01	0.203
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.263289e-01	0.203
Glycolysis	R-HSA-70171	6.269391e-01	0.203
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.302190e-01	0.201
Nuclear signaling by ERBB4	R-HSA-1251985	6.302190e-01	0.201
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	6.373099e-01	0.196
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.377037e-01	0.195
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.377209e-01	0.195
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	6.377209e-01	0.195
G0 and Early G1	R-HSA-1538133	6.377209e-01	0.195
Extra-nuclear estrogen signaling	R-HSA-9009391	6.389285e-01	0.195
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.424877e-01	0.192
G beta:gamma signalling through BTK	R-HSA-8964315	6.434230e-01	0.192
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.434230e-01	0.192
Processive synthesis on the lagging strand	R-HSA-69183	6.434230e-01	0.192
DNA Damage Reversal	R-HSA-73942	6.434230e-01	0.192
Formation of the anterior neural plate	R-HSA-9823739	6.434230e-01	0.192
Biotin transport and metabolism	R-HSA-196780	6.434230e-01	0.192
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.458984e-01	0.190
Signaling by LTK in cancer	R-HSA-9842640	6.458984e-01	0.190
Erythropoietin activates STAT5	R-HSA-9027283	6.458984e-01	0.190
Autointegration results in viral DNA circles	R-HSA-177539	6.458984e-01	0.190
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.458984e-01	0.190
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.458984e-01	0.190
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	6.458984e-01	0.190
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	6.458984e-01	0.190
MET Receptor Activation	R-HSA-6806942	6.458984e-01	0.190
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	6.458984e-01	0.190
G2/M DNA replication checkpoint	R-HSA-69478	6.458984e-01	0.190
Neurofascin interactions	R-HSA-447043	6.458984e-01	0.190
Lactose synthesis	R-HSA-5653890	6.458984e-01	0.190
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.458984e-01	0.190
Regulation of NFE2L2 gene expression	R-HSA-9818749	6.458984e-01	0.190
Metabolism of vitamin K	R-HSA-6806664	6.458984e-01	0.190
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.458984e-01	0.190
CREB3 factors activate genes	R-HSA-8874211	6.458984e-01	0.190
HDL clearance	R-HSA-8964011	6.458984e-01	0.190
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	6.466750e-01	0.189
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	6.466750e-01	0.189
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	6.466750e-01	0.189
Transcription of the HIV genome	R-HSA-167172	6.483039e-01	0.188
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.483197e-01	0.188
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.483197e-01	0.188
MyD88-independent TLR4 cascade	R-HSA-166166	6.490713e-01	0.188
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.490713e-01	0.188
Deadenylation-dependent mRNA decay	R-HSA-429914	6.525566e-01	0.185
Triglyceride metabolism	R-HSA-8979227	6.525566e-01	0.185
Transport of the SLBP independent Mature mRNA	R-HSA-159227	6.575861e-01	0.182
FGFR1 mutant receptor activation	R-HSA-1839124	6.575861e-01	0.182
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	6.613194e-01	0.180
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.658502e-01	0.177
HIV Transcription Initiation	R-HSA-167161	6.658502e-01	0.177
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.658502e-01	0.177
Translation of Structural Proteins	R-HSA-9683701	6.658502e-01	0.177
Platelet degranulation	R-HSA-114608	6.674777e-01	0.176
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.691912e-01	0.174
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.691912e-01	0.174
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.708060e-01	0.173
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.708060e-01	0.173
Phase 4 - resting membrane potential	R-HSA-5576886	6.708060e-01	0.173
TRAF6 mediated NF-kB activation	R-HSA-933542	6.718725e-01	0.173
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	6.767028e-01	0.170
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.767028e-01	0.170
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.767028e-01	0.170
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.820008e-01	0.166
Cleavage of the damaged pyrimidine	R-HSA-110329	6.827995e-01	0.166
Depyrimidination	R-HSA-73928	6.827995e-01	0.166
MET activates PI3K/AKT signaling	R-HSA-8851907	6.844883e-01	0.165
TRIF-mediated programmed cell death	R-HSA-2562578	6.844883e-01	0.165
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.844883e-01	0.165
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.844883e-01	0.165
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.844883e-01	0.165
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.844883e-01	0.165
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.844883e-01	0.165
PTK6 Expression	R-HSA-8849473	6.844883e-01	0.165
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.844883e-01	0.165
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.844883e-01	0.165
Cysteine formation from homocysteine	R-HSA-1614603	6.844883e-01	0.165
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.844883e-01	0.165
Ca2+ activated K+ channels	R-HSA-1296052	6.844883e-01	0.165
VLDL clearance	R-HSA-8964046	6.844883e-01	0.165
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	6.844883e-01	0.165
Cation-coupled Chloride cotransporters	R-HSA-426117	6.844883e-01	0.165
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.844883e-01	0.165
RSV-host interactions	R-HSA-9833110	6.847826e-01	0.164
Acyl chain remodelling of PS	R-HSA-1482801	6.930601e-01	0.159
Gap junction assembly	R-HSA-190861	6.950635e-01	0.158
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.964580e-01	0.157
Heme assimilation	R-HSA-9927020	6.964580e-01	0.157
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.964580e-01	0.157
Coenzyme A biosynthesis	R-HSA-196783	6.964580e-01	0.157
Passive transport by Aquaporins	R-HSA-432047	6.964580e-01	0.157
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.964580e-01	0.157
Response to metal ions	R-HSA-5660526	6.964580e-01	0.157
RNA Polymerase II Promoter Escape	R-HSA-73776	6.991599e-01	0.155
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.999568e-01	0.155
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.999568e-01	0.155
Mitotic G1 phase and G1/S transition	R-HSA-453279	7.023293e-01	0.153
Transcriptional regulation by small RNAs	R-HSA-5578749	7.024719e-01	0.153
Generic Transcription Pathway	R-HSA-212436	7.025467e-01	0.153
Base Excision Repair	R-HSA-73884	7.036956e-01	0.153
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.089465e-01	0.149
Post-translational protein phosphorylation	R-HSA-8957275	7.103866e-01	0.149
Hemostasis	R-HSA-109582	7.112220e-01	0.148
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	7.126659e-01	0.147
Signalling to ERKs	R-HSA-187687	7.126659e-01	0.147
Signaling by FLT3 fusion proteins	R-HSA-9703465	7.131979e-01	0.147
TRP channels	R-HSA-3295583	7.131979e-01	0.147
G1 Phase	R-HSA-69236	7.149271e-01	0.146
Cyclin D associated events in G1	R-HSA-69231	7.149271e-01	0.146
Amine ligand-binding receptors	R-HSA-375280	7.149271e-01	0.146
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	7.188747e-01	0.143
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.188747e-01	0.143
Signaling by MRAS-complex mutants	R-HSA-9660537	7.188747e-01	0.143
MET receptor recycling	R-HSA-8875656	7.188747e-01	0.143
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	7.188747e-01	0.143
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	7.188747e-01	0.143
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.188747e-01	0.143
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	7.188747e-01	0.143
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.188747e-01	0.143
Regulation by c-FLIP	R-HSA-3371378	7.188747e-01	0.143
Co-stimulation by ICOS	R-HSA-9927354	7.188747e-01	0.143
SLC-mediated bile acid transport	R-HSA-9958517	7.188747e-01	0.143
Dimerization of procaspase-8	R-HSA-69416	7.188747e-01	0.143
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.201266e-01	0.143
PI3K events in ERBB2 signaling	R-HSA-1963642	7.204309e-01	0.142
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.204309e-01	0.142
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.204309e-01	0.142
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.204309e-01	0.142
Uptake and function of anthrax toxins	R-HSA-5210891	7.204309e-01	0.142
Developmental Biology	R-HSA-1266738	7.233867e-01	0.141
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	7.270204e-01	0.138
Gastrulation	R-HSA-9758941	7.287766e-01	0.137
GPVI-mediated activation cascade	R-HSA-114604	7.295117e-01	0.137
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.300995e-01	0.137
Somitogenesis	R-HSA-9824272	7.300995e-01	0.137
Cristae formation	R-HSA-8949613	7.322992e-01	0.135
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.322992e-01	0.135
G alpha (z) signalling events	R-HSA-418597	7.323933e-01	0.135
G1/S Transition	R-HSA-69206	7.382024e-01	0.132
HCMV Infection	R-HSA-9609646	7.391068e-01	0.131
HCMV Early Events	R-HSA-9609690	7.413778e-01	0.130
Mitochondrial biogenesis	R-HSA-1592230	7.421838e-01	0.129
GAB1 signalosome	R-HSA-180292	7.427859e-01	0.129
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.427859e-01	0.129
Platelet sensitization by LDL	R-HSA-432142	7.427859e-01	0.129
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	7.427859e-01	0.129
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	7.427859e-01	0.129
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.446784e-01	0.128
Vpr-mediated nuclear import of PICs	R-HSA-180910	7.456066e-01	0.127
Signaling by FGFR1	R-HSA-5654736	7.457701e-01	0.127
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	7.495153e-01	0.125
Interleukin-21 signaling	R-HSA-9020958	7.495153e-01	0.125
AKT phosphorylates targets in the nucleus	R-HSA-198693	7.495153e-01	0.125
MAPK1 (ERK2) activation	R-HSA-112411	7.495153e-01	0.125
CASP8 activity is inhibited	R-HSA-5218900	7.495153e-01	0.125
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.495153e-01	0.125
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.495153e-01	0.125
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.495153e-01	0.125
Inactivation of CDC42 and RAC1	R-HSA-428543	7.495153e-01	0.125
mRNA Editing	R-HSA-75072	7.495153e-01	0.125
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.495153e-01	0.125
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.495153e-01	0.125
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.495153e-01	0.125
Interleukin-1 processing	R-HSA-448706	7.495153e-01	0.125
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.495153e-01	0.125
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.503828e-01	0.125
Pyroptosis	R-HSA-5620971	7.503828e-01	0.125
Signaling by Nuclear Receptors	R-HSA-9006931	7.576948e-01	0.121
Synthesis of PC	R-HSA-1483191	7.586673e-01	0.120
MET promotes cell motility	R-HSA-8875878	7.609596e-01	0.119
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	7.609596e-01	0.119
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	7.609596e-01	0.119
Translation of Structural Proteins	R-HSA-9694635	7.621398e-01	0.118
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.635909e-01	0.117
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	7.635909e-01	0.117
Germ layer formation at gastrulation	R-HSA-9754189	7.635909e-01	0.117
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	7.635909e-01	0.117
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.635909e-01	0.117
Specification of the neural plate border	R-HSA-9834899	7.635909e-01	0.117
The NLRP3 inflammasome	R-HSA-844456	7.635909e-01	0.117
Maturation of nucleoprotein	R-HSA-9694631	7.635909e-01	0.117
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.710584e-01	0.113
Co-stimulation by CD28	R-HSA-389356	7.720718e-01	0.112
Metal ion SLC transporters	R-HSA-425410	7.720718e-01	0.112
ABC transporter disorders	R-HSA-5619084	7.729795e-01	0.112
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.755825e-01	0.110
RAS processing	R-HSA-9648002	7.755825e-01	0.110
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.768179e-01	0.110
Binding and entry of HIV virion	R-HSA-173107	7.768179e-01	0.110
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	7.768179e-01	0.110
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.768179e-01	0.110
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	7.768179e-01	0.110
Sperm Motility And Taxes	R-HSA-1300642	7.768179e-01	0.110
Defective factor IX causes hemophilia B	R-HSA-9668250	7.768179e-01	0.110
Receptor Mediated Mitophagy	R-HSA-8934903	7.768179e-01	0.110
Metabolism of non-coding RNA	R-HSA-194441	7.829771e-01	0.106
snRNP Assembly	R-HSA-191859	7.829771e-01	0.106
Peroxisomal protein import	R-HSA-9033241	7.829771e-01	0.106
Amino acid transport across the plasma membrane	R-HSA-352230	7.829771e-01	0.106
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.834565e-01	0.106
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	7.835953e-01	0.106
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.835953e-01	0.106
Interleukin-37 signaling	R-HSA-9008059	7.835953e-01	0.106
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.868816e-01	0.104
HIV Transcription Elongation	R-HSA-167169	7.894899e-01	0.103
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.894899e-01	0.103
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.894899e-01	0.103
Interactions of Vpr with host cellular proteins	R-HSA-176033	7.894899e-01	0.103
Interactions of Rev with host cellular proteins	R-HSA-177243	7.894899e-01	0.103
Interleukin-2 family signaling	R-HSA-451927	7.894899e-01	0.103
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	7.916882e-01	0.101
Signaling by FGFR2	R-HSA-5654738	7.935733e-01	0.100
Glutathione conjugation	R-HSA-156590	7.944194e-01	0.100
Azathioprine ADME	R-HSA-9748787	7.971601e-01	0.098
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	7.987820e-01	0.098
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	7.987820e-01	0.098
Trafficking of AMPA receptors	R-HSA-399719	7.987820e-01	0.098
Molecules associated with elastic fibres	R-HSA-2129379	7.987820e-01	0.098
G-protein activation	R-HSA-202040	8.008425e-01	0.096
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	8.008425e-01	0.096
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.008425e-01	0.096
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	8.011459e-01	0.096
vRNA Synthesis	R-HSA-192814	8.011459e-01	0.096
vRNP Assembly	R-HSA-192905	8.011459e-01	0.096
Formation of the posterior neural plate	R-HSA-9832991	8.011459e-01	0.096
RHOBTB3 ATPase cycle	R-HSA-9706019	8.011459e-01	0.096
Bicarbonate transporters	R-HSA-425381	8.011459e-01	0.096
Transport of RCbl within the body	R-HSA-9758890	8.011459e-01	0.096
Chylomicron assembly	R-HSA-8963888	8.011459e-01	0.096
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	8.011459e-01	0.096
Vitamin B1 (thiamin) metabolism	R-HSA-196819	8.011459e-01	0.096
Regulation of localization of FOXO transcription factors	R-HSA-9614399	8.011459e-01	0.096
LGI-ADAM interactions	R-HSA-5682910	8.011459e-01	0.096
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	8.011459e-01	0.096
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.011459e-01	0.096
Interleukin-2 signaling	R-HSA-9020558	8.011459e-01	0.096
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.073084e-01	0.093
FOXO-mediated transcription	R-HSA-9614085	8.132911e-01	0.090
Intra-Golgi traffic	R-HSA-6811438	8.152261e-01	0.089
Signaling by FGFR1 in disease	R-HSA-5655302	8.152261e-01	0.089
Mitochondrial calcium ion transport	R-HSA-8949215	8.174401e-01	0.088
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	8.213055e-01	0.085
Cytoprotection by HMOX1	R-HSA-9707564	8.218000e-01	0.085
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.228234e-01	0.085
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	8.228234e-01	0.085
Sensing of DNA Double Strand Breaks	R-HSA-5693548	8.228234e-01	0.085
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	8.228234e-01	0.085
Proton-coupled monocarboxylate transport	R-HSA-433692	8.228234e-01	0.085
Glucose metabolism	R-HSA-70326	8.233156e-01	0.084
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.259620e-01	0.083
IPs transport between nucleus and cytosol	R-HSA-1855170	8.264798e-01	0.083
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.264798e-01	0.083
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.264798e-01	0.083
Cardiogenesis	R-HSA-9733709	8.264798e-01	0.083
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.264798e-01	0.083
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	8.270930e-01	0.082
Cytosolic tRNA aminoacylation	R-HSA-379716	8.270930e-01	0.082
Protein localization	R-HSA-9609507	8.298926e-01	0.081
FGFR2 alternative splicing	R-HSA-6803529	8.327872e-01	0.079
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	8.327872e-01	0.079
RAF-independent MAPK1/3 activation	R-HSA-112409	8.327872e-01	0.079
Neurotoxicity of clostridium toxins	R-HSA-168799	8.327872e-01	0.079
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	8.327872e-01	0.079
Viral Infection Pathways	R-HSA-9824446	8.368665e-01	0.077
PI Metabolism	R-HSA-1483255	8.371653e-01	0.077
Signaling by SCF-KIT	R-HSA-1433557	8.383202e-01	0.077
SARS-CoV Infections	R-HSA-9679506	8.389951e-01	0.076
Effects of PIP2 hydrolysis	R-HSA-114508	8.390611e-01	0.076
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	8.390611e-01	0.076
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.390611e-01	0.076
Heme degradation	R-HSA-189483	8.390611e-01	0.076
Miscellaneous transport and binding events	R-HSA-5223345	8.390611e-01	0.076
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.407638e-01	0.075
MET activates RAS signaling	R-HSA-8851805	8.421388e-01	0.075
Scavenging by Class F Receptors	R-HSA-3000484	8.421388e-01	0.075
Polymerase switching	R-HSA-69091	8.421388e-01	0.075
Leading Strand Synthesis	R-HSA-69109	8.421388e-01	0.075
GRB2 events in EGFR signaling	R-HSA-179812	8.421388e-01	0.075
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.421388e-01	0.075
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	8.421388e-01	0.075
Signaling by LTK	R-HSA-9842663	8.421388e-01	0.075
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.421388e-01	0.075
Diseases associated with surfactant metabolism	R-HSA-5687613	8.421388e-01	0.075
Maple Syrup Urine Disease	R-HSA-9865114	8.421388e-01	0.075
Regulation of IFNG signaling	R-HSA-877312	8.421388e-01	0.075
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.421388e-01	0.075
Estrogen biosynthesis	R-HSA-193144	8.421388e-01	0.075
Interleukin receptor SHC signaling	R-HSA-912526	8.469591e-01	0.072
ABC transporters in lipid homeostasis	R-HSA-1369062	8.469591e-01	0.072
Organic anion transport by SLCO transporters	R-HSA-879518	8.469591e-01	0.072
Mitochondrial mRNA modification	R-HSA-9937008	8.469591e-01	0.072
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.469591e-01	0.072
Formation of the ureteric bud	R-HSA-9830674	8.469591e-01	0.072
Growth hormone receptor signaling	R-HSA-982772	8.469591e-01	0.072
eNOS activation	R-HSA-203615	8.508458e-01	0.070
Nuclear import of Rev protein	R-HSA-180746	8.508458e-01	0.070
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	8.575707e-01	0.067
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	8.593496e-01	0.066
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.593496e-01	0.066
Chylomicron remodeling	R-HSA-8963901	8.593496e-01	0.066
OGDH complex synthesizes succinyl-CoA from 2-OG	R-HSA-9853506	8.593496e-01	0.066
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.593496e-01	0.066
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	8.593496e-01	0.066
Processing of SMDT1	R-HSA-8949664	8.593496e-01	0.066
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.593496e-01	0.066
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.593496e-01	0.066
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.593496e-01	0.066
Platelet Adhesion to exposed collagen	R-HSA-75892	8.593496e-01	0.066
Maturation of nucleoprotein	R-HSA-9683610	8.593496e-01	0.066
Interleukin-6 signaling	R-HSA-1059683	8.593496e-01	0.066
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.593496e-01	0.066
Adaptive Immune System	R-HSA-1280218	8.598790e-01	0.066
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.600295e-01	0.065
Thromboxane signalling through TP receptor	R-HSA-428930	8.600295e-01	0.065
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.600295e-01	0.065
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.600295e-01	0.065
PERK regulates gene expression	R-HSA-381042	8.618708e-01	0.065
SLC-mediated transport of amino acids	R-HSA-9958863	8.618751e-01	0.065
Potential therapeutics for SARS	R-HSA-9679191	8.698203e-01	0.061
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.720702e-01	0.059
Activation of G protein gated Potassium channels	R-HSA-1296041	8.720702e-01	0.059
G protein gated Potassium channels	R-HSA-1296059	8.720702e-01	0.059
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.720702e-01	0.059
VEGFR2 mediated cell proliferation	R-HSA-5218921	8.720702e-01	0.059
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.720702e-01	0.059
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.720702e-01	0.059
Hyaluronan degradation	R-HSA-2160916	8.720702e-01	0.059
Lysosome Vesicle Biogenesis	R-HSA-432720	8.721730e-01	0.059
Glycosphingolipid transport	R-HSA-9845576	8.721730e-01	0.059
Removal of the Flap Intermediate	R-HSA-69166	8.746848e-01	0.058
Synthesis of IPs in the nucleus	R-HSA-1855191	8.746848e-01	0.058
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	8.746848e-01	0.058
Prolactin receptor signaling	R-HSA-1170546	8.746848e-01	0.058
Physiological factors	R-HSA-5578768	8.746848e-01	0.058
Malate-aspartate shuttle	R-HSA-9856872	8.746848e-01	0.058
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.746848e-01	0.058
Glycerophospholipid catabolism	R-HSA-6814848	8.746848e-01	0.058
Zinc transporters	R-HSA-435354	8.746848e-01	0.058
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.746848e-01	0.058
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	8.772783e-01	0.057
Gene Silencing by RNA	R-HSA-211000	8.777415e-01	0.057
C-type lectin receptors (CLRs)	R-HSA-5621481	8.807759e-01	0.055
TRAF6 mediated IRF7 activation	R-HSA-933541	8.817892e-01	0.055
Toll-like Receptor Cascades	R-HSA-168898	8.820055e-01	0.055
MET activates PTK2 signaling	R-HSA-8874081	8.831502e-01	0.054
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.831502e-01	0.054
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.831502e-01	0.054
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.831502e-01	0.054
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.831502e-01	0.054
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	8.831502e-01	0.054
Stimuli-sensing channels	R-HSA-2672351	8.836326e-01	0.054
Transport to the Golgi and subsequent modification	R-HSA-948021	8.870927e-01	0.052
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.873432e-01	0.052
Erythropoietin activates RAS	R-HSA-9027284	8.883489e-01	0.051
SHC1 events in EGFR signaling	R-HSA-180336	8.883489e-01	0.051
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	8.883489e-01	0.051
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.883489e-01	0.051
Other semaphorin interactions	R-HSA-416700	8.883489e-01	0.051
p38MAPK events	R-HSA-171007	8.883489e-01	0.051
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	8.883489e-01	0.051
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.883489e-01	0.051
Elastic fibre formation	R-HSA-1566948	8.907553e-01	0.050
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.907553e-01	0.050
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.907553e-01	0.050
tRNA Aminoacylation	R-HSA-379724	8.914457e-01	0.050
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.919284e-01	0.050
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.933358e-01	0.049
Triglyceride biosynthesis	R-HSA-75109	8.933358e-01	0.049
Synthesis of PE	R-HSA-1483213	8.933358e-01	0.049
Maturation of hRSV A proteins	R-HSA-9828806	8.933358e-01	0.049
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.933358e-01	0.049
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.943200e-01	0.049
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.991069e-01	0.046
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.003302e-01	0.046
Class I peroxisomal membrane protein import	R-HSA-9603798	9.005237e-01	0.046
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.005237e-01	0.046
Differentiation of T cells	R-HSA-9945266	9.005237e-01	0.046
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	9.005237e-01	0.046
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	9.005237e-01	0.046
Killing mechanisms	R-HSA-9664420	9.005237e-01	0.046
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.005237e-01	0.046
Attachment and Entry	R-HSA-9678110	9.005237e-01	0.046
Atorvastatin ADME	R-HSA-9754706	9.005237e-01	0.046
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	9.026903e-01	0.044
Formation of the Early Elongation Complex	R-HSA-113418	9.026903e-01	0.044
Inflammasomes	R-HSA-622312	9.026903e-01	0.044
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	9.026903e-01	0.044
Mitochondrial protein import	R-HSA-1268020	9.049278e-01	0.043
Diseases of Immune System	R-HSA-5260271	9.068786e-01	0.042
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.068786e-01	0.042
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.109092e-01	0.041
Signaling by Erythropoietin	R-HSA-9006335	9.112738e-01	0.040
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.112738e-01	0.040
Regulation of CDH11 Expression and Function	R-HSA-9759475	9.112738e-01	0.040
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.112738e-01	0.040
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.112738e-01	0.040
Glucagon-type ligand receptors	R-HSA-420092	9.112738e-01	0.040
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.113716e-01	0.040
Glycine degradation	R-HSA-6783984	9.113716e-01	0.040
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	9.113716e-01	0.040
tRNA modification in the mitochondrion	R-HSA-6787450	9.113716e-01	0.040
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.113716e-01	0.040
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.141037e-01	0.039
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.154179e-01	0.038
Ion transport by P-type ATPases	R-HSA-936837	9.169251e-01	0.038
DAP12 signaling	R-HSA-2424491	9.191432e-01	0.037
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.191432e-01	0.037
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	9.191432e-01	0.037
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.191432e-01	0.037
Activation of BH3-only proteins	R-HSA-114452	9.191432e-01	0.037
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.201481e-01	0.036
Scavenging by Class A Receptors	R-HSA-3000480	9.208149e-01	0.036
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.208149e-01	0.036
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.210371e-01	0.036
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.210371e-01	0.036
Regulation of NPAS4 gene expression	R-HSA-9768759	9.210371e-01	0.036
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	9.210371e-01	0.036
Choline catabolism	R-HSA-6798163	9.210371e-01	0.036
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.210371e-01	0.036
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.228375e-01	0.035
Pyruvate metabolism	R-HSA-70268	9.248478e-01	0.034
Potassium Channels	R-HSA-1296071	9.249743e-01	0.034
Platelet homeostasis	R-HSA-418346	9.256977e-01	0.034
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.263520e-01	0.033
Downstream signal transduction	R-HSA-186763	9.263520e-01	0.033
Synaptic adhesion-like molecules	R-HSA-8849932	9.296490e-01	0.032
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.296490e-01	0.032
FOXO-mediated transcription of cell death genes	R-HSA-9614657	9.296490e-01	0.032
Vitamin D (calciferol) metabolism	R-HSA-196791	9.296490e-01	0.032
Integrin cell surface interactions	R-HSA-216083	9.302468e-01	0.031
Inwardly rectifying K+ channels	R-HSA-1296065	9.329508e-01	0.030
Signaling by FGFR	R-HSA-190236	9.332461e-01	0.030
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.373222e-01	0.028
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.373222e-01	0.028
Diseases of hemostasis	R-HSA-9671793	9.373222e-01	0.028
HDL remodeling	R-HSA-8964058	9.373222e-01	0.028
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.373222e-01	0.028
PI3K/AKT Signaling in Cancer	R-HSA-2219528	9.377918e-01	0.028
Proteasome assembly	R-HSA-9907900	9.381700e-01	0.028
Surfactant metabolism	R-HSA-5683826	9.381700e-01	0.028
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	9.389868e-01	0.027
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.412585e-01	0.026
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	9.431245e-01	0.025
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.441588e-01	0.025
VxPx cargo-targeting to cilium	R-HSA-5620916	9.441588e-01	0.025
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.441588e-01	0.025
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.448694e-01	0.025
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.477084e-01	0.023
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.477084e-01	0.023
Leishmania phagocytosis	R-HSA-9664417	9.484566e-01	0.023
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.484566e-01	0.023
Parasite infection	R-HSA-9664407	9.484566e-01	0.023
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.495444e-01	0.022
Signal amplification	R-HSA-392518	9.495444e-01	0.022
Hyaluronan metabolism	R-HSA-2142845	9.495444e-01	0.022
NPAS4 regulates expression of target genes	R-HSA-9768919	9.495444e-01	0.022
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.495444e-01	0.022
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.502501e-01	0.022
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.502501e-01	0.022
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.502501e-01	0.022
Phenylalanine metabolism	R-HSA-8964208	9.502501e-01	0.022
ERK/MAPK targets	R-HSA-198753	9.502501e-01	0.022
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.502501e-01	0.022
Zygotic genome activation (ZGA)	R-HSA-9819196	9.502501e-01	0.022
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.502501e-01	0.022
Signalling to RAS	R-HSA-167044	9.502501e-01	0.022
RAB geranylgeranylation	R-HSA-8873719	9.531825e-01	0.021
Metabolism of polyamines	R-HSA-351202	9.531825e-01	0.021
Transferrin endocytosis and recycling	R-HSA-917977	9.541457e-01	0.020
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.541457e-01	0.020
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.556772e-01	0.020
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.556772e-01	0.020
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.556772e-01	0.020
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.556772e-01	0.020
Serine metabolism	R-HSA-977347	9.556772e-01	0.020
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.556772e-01	0.020
Attachment and Entry	R-HSA-9694614	9.556772e-01	0.020
Ribavirin ADME	R-HSA-9755088	9.556772e-01	0.020
Viral Messenger RNA Synthesis	R-HSA-168325	9.566871e-01	0.019
RNA Polymerase III Transcription	R-HSA-74158	9.583440e-01	0.018
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.583440e-01	0.018
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.583440e-01	0.018
RUNX2 regulates bone development	R-HSA-8941326	9.583440e-01	0.018
Signaling by FGFR in disease	R-HSA-1226099	9.589735e-01	0.018
tRNA processing in the nucleus	R-HSA-6784531	9.599478e-01	0.018
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.605126e-01	0.017
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.605126e-01	0.017
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.605126e-01	0.017
Biosynthesis of D-series resolvins	R-HSA-9018676	9.605126e-01	0.017
Signaling by KIT in disease	R-HSA-9669938	9.605126e-01	0.017
Cellular hexose transport	R-HSA-189200	9.605126e-01	0.017
Ethanol oxidation	R-HSA-71384	9.605126e-01	0.017
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.605126e-01	0.017
Voltage gated Potassium channels	R-HSA-1296072	9.621723e-01	0.017
Mitochondrial translation elongation	R-HSA-5389840	9.625744e-01	0.017
PI3K Cascade	R-HSA-109704	9.628121e-01	0.016
Neuronal System	R-HSA-112316	9.634843e-01	0.016
HCMV Late Events	R-HSA-9610379	9.647927e-01	0.016
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.648207e-01	0.016
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.648207e-01	0.016
Free fatty acids regulate insulin secretion	R-HSA-400451	9.648207e-01	0.016
Carnitine shuttle	R-HSA-200425	9.648207e-01	0.016
Biosynthesis of maresins	R-HSA-9018682	9.648207e-01	0.016
The phototransduction cascade	R-HSA-2514856	9.658879e-01	0.015
Ion channel transport	R-HSA-983712	9.662526e-01	0.015
Complex III assembly	R-HSA-9865881	9.686591e-01	0.014
Mitochondrial RNA degradation	R-HSA-9836573	9.686591e-01	0.014
TNFs bind their physiological receptors	R-HSA-5669034	9.686591e-01	0.014
Interleukin-6 family signaling	R-HSA-6783589	9.686591e-01	0.014
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.687226e-01	0.014
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.688397e-01	0.014
Signaling by ALK	R-HSA-201556	9.688397e-01	0.014
Nuclear Receptor transcription pathway	R-HSA-383280	9.694618e-01	0.013
Amino acids regulate mTORC1	R-HSA-9639288	9.713335e-01	0.013
rRNA processing in the mitochondrion	R-HSA-8868766	9.717335e-01	0.012
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.717335e-01	0.012
Long-term potentiation	R-HSA-9620244	9.720788e-01	0.012
Tight junction interactions	R-HSA-420029	9.720788e-01	0.012
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.720788e-01	0.012
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.720788e-01	0.012
Fertilization	R-HSA-1187000	9.720788e-01	0.012
Formation of the nephric duct	R-HSA-9830364	9.720788e-01	0.012
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.720788e-01	0.012
Laminin interactions	R-HSA-3000157	9.720788e-01	0.012
Inositol phosphate metabolism	R-HSA-1483249	9.736377e-01	0.012
Cardiac conduction	R-HSA-5576891	9.737205e-01	0.012
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.743670e-01	0.011
Maturation of spike protein	R-HSA-9694548	9.743670e-01	0.011
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.751256e-01	0.011
Sphingolipid catabolism	R-HSA-9845614	9.751256e-01	0.011
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.751256e-01	0.011
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.759152e-01	0.011
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.778401e-01	0.010
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.778401e-01	0.010
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.778401e-01	0.010
Insulin processing	R-HSA-264876	9.778401e-01	0.010
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.779818e-01	0.010
COPII-mediated vesicle transport	R-HSA-204005	9.789161e-01	0.009
Activation of GABAB receptors	R-HSA-991365	9.789407e-01	0.009
GABA B receptor activation	R-HSA-977444	9.789407e-01	0.009
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.789407e-01	0.009
IRS-mediated signalling	R-HSA-112399	9.798508e-01	0.009
Insulin receptor recycling	R-HSA-77387	9.802584e-01	0.009
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.802584e-01	0.009
Iron assimilation using enterobactin	R-HSA-9638334	9.802584e-01	0.009
Pyrimidine salvage	R-HSA-73614	9.802584e-01	0.009
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.820137e-01	0.008
mRNA Capping	R-HSA-72086	9.824130e-01	0.008
Thyroxine biosynthesis	R-HSA-209968	9.824130e-01	0.008
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.824130e-01	0.008
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.824130e-01	0.008
DAP12 interactions	R-HSA-2172127	9.827190e-01	0.008
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.827190e-01	0.008
Diseases of carbohydrate metabolism	R-HSA-5663084	9.835329e-01	0.007
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.835356e-01	0.007
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.835471e-01	0.007
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.843326e-01	0.007
Neurotransmitter clearance	R-HSA-112311	9.843326e-01	0.007
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.845916e-01	0.007
Extracellular matrix organization	R-HSA-1474244	9.846413e-01	0.007
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.858352e-01	0.006
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.858352e-01	0.006
IRS-related events triggered by IGF1R	R-HSA-2428928	9.859191e-01	0.006
Cargo concentration in the ER	R-HSA-5694530	9.860427e-01	0.006
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.860427e-01	0.006
Mitochondrial translation initiation	R-HSA-5368286	9.860579e-01	0.006
NCAM signaling for neurite out-growth	R-HSA-375165	9.871365e-01	0.006
Signaling by PDGF	R-HSA-186797	9.871365e-01	0.006
Neurotransmitter release cycle	R-HSA-112310	9.887985e-01	0.005
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	9.889236e-01	0.005
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.889236e-01	0.005
SLC-mediated transport of organic anions	R-HSA-9955298	9.891692e-01	0.005
IGF1R signaling cascade	R-HSA-2428924	9.892748e-01	0.005
Insulin receptor signalling cascade	R-HSA-74751	9.892748e-01	0.005
Neddylation	R-HSA-8951664	9.892831e-01	0.005
Acyl chain remodelling of PC	R-HSA-1482788	9.901328e-01	0.004
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.902112e-01	0.004
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.904292e-01	0.004
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.912101e-01	0.004
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.912101e-01	0.004
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.912101e-01	0.004
Complex IV assembly	R-HSA-9864848	9.914220e-01	0.004
Branched-chain amino acid catabolism	R-HSA-70895	9.914220e-01	0.004
Transmission across Chemical Synapses	R-HSA-112315	9.914967e-01	0.004
Kidney development	R-HSA-9830369	9.918531e-01	0.004
Leishmania infection	R-HSA-9658195	9.918778e-01	0.004
Parasitic Infection Pathways	R-HSA-9824443	9.918778e-01	0.004
Acyl chain remodelling of PE	R-HSA-1482839	9.921698e-01	0.003
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.921698e-01	0.003
G alpha (s) signalling events	R-HSA-418555	9.922704e-01	0.003
Mitochondrial protein degradation	R-HSA-9837999	9.925010e-01	0.003
Nucleotide biosynthesis	R-HSA-8956320	9.929928e-01	0.003
G1/S-Specific Transcription	R-HSA-69205	9.930248e-01	0.003
FGFR2 mutant receptor activation	R-HSA-1839126	9.930248e-01	0.003
NCAM1 interactions	R-HSA-419037	9.937865e-01	0.003
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.937865e-01	0.003
SLC-mediated transport of organic cations	R-HSA-549127	9.937865e-01	0.003
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.937865e-01	0.003
Metabolism of folate and pterines	R-HSA-196757	9.937865e-01	0.003
Metal ion assimilation from the host	R-HSA-9638482	9.943758e-01	0.002
Metabolism of porphyrins	R-HSA-189445	9.943758e-01	0.002
Mitochondrial translation termination	R-HSA-5419276	9.944214e-01	0.002
Purine salvage	R-HSA-74217	9.944650e-01	0.002
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.944650e-01	0.002
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.948768e-01	0.002
Purine catabolism	R-HSA-74259	9.948768e-01	0.002
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.950695e-01	0.002
Pentose phosphate pathway	R-HSA-71336	9.950695e-01	0.002
FCERI mediated NF-kB activation	R-HSA-2871837	9.954536e-01	0.002
Tryptophan catabolism	R-HSA-71240	9.956080e-01	0.002
ROS and RNS production in phagocytes	R-HSA-1222556	9.957521e-01	0.002
Aflatoxin activation and detoxification	R-HSA-5423646	9.960877e-01	0.002
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.961991e-01	0.002
Interferon gamma signaling	R-HSA-877300	9.962190e-01	0.002
Developmental Cell Lineages	R-HSA-9734767	9.963732e-01	0.002
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.965150e-01	0.002
GABA receptor activation	R-HSA-977443	9.965698e-01	0.001
Collagen degradation	R-HSA-1442490	9.969049e-01	0.001
Signaling by Insulin receptor	R-HSA-74752	9.973069e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.974813e-01	0.001
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.975369e-01	0.001
Cell surface interactions at the vascular wall	R-HSA-202733	9.977854e-01	0.001
PPARA activates gene expression	R-HSA-1989781	9.979324e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.980960e-01	0.001
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.981534e-01	0.001
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.981802e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.982139e-01	0.001
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.982593e-01	0.001
Plasma lipoprotein remodeling	R-HSA-8963899	9.984495e-01	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.986189e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.986189e-01	0.001
Signaling by FGFR2 in disease	R-HSA-5655253	9.987699e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.987818e-01	0.001
Disorders of transmembrane transporters	R-HSA-5619115	9.988100e-01	0.001
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.988905e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.989025e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.989066e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.993104e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.993858e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.994733e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.995032e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.995032e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.995260e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.995888e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.996135e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.996162e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.996402e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.996558e-01	0.000
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.996784e-01	0.000
Infectious disease	R-HSA-5663205	9.996830e-01	0.000
SLC transporter disorders	R-HSA-5619102	9.997041e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.997442e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.997752e-01	0.000
Transport of small molecules	R-HSA-382551	9.997968e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.998139e-01	0.000
Metabolism of proteins	R-HSA-392499	9.998253e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998282e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.998282e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.998287e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.998470e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.998627e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.998673e-01	0.000
Immune System	R-HSA-168256	9.998824e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998906e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.998919e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.998919e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.998919e-01	0.000
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.999134e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999143e-01	0.000
Innate Immune System	R-HSA-168249	9.999205e-01	0.000
Collagen formation	R-HSA-1474290	9.999222e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999320e-01	0.000
tRNA processing	R-HSA-72306	9.999357e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999372e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999464e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999572e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999581e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999642e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999661e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999745e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999761e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999786e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999831e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999854e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999866e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999911e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999920e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999931e-01	0.000
FCGR activation	R-HSA-2029481	9.999933e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999952e-01	0.000
Drug ADME	R-HSA-9748784	9.999967e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999970e-01	0.000
Disease	R-HSA-1643685	9.999980e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999981e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999986e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999993e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999993e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999995e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999996e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999997e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999999e-01	0.000
Keratinization	R-HSA-6805567	9.999999e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999999e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000