MTOR

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00141 S422 SIGNOR|EPSD|PSP SGK1 SGK PDsVLVTAsVKEAAEAFLGFsYAPPTDSFL___________
O00418 S70 SIGNOR EEF2K QNVNSKVNKYysNLtKsERysssGsPANsFHFKEAWKHAIQ
O00418 S72 SIGNOR|EPSD|PSP EEF2K VNSKVNKYysNLtKsERysssGsPANsFHFKEAWKHAIQKA
O00418 S74 SIGNOR|EPSD|PSP EEF2K SKVNKYysNLtKsERysssGsPANsFHFKEAWKHAIQKAKH
O00418 Y69 SIGNOR EEF2K NQNVNSKVNKYysNLtKsERysssGsPANsFHFKEAWKHAI
O00429 S616 SIGNOR DNM1L DLP1 DRP1 SKAEELLAEEKsKPIPIMPAsPQKGHAVNLLDVPVPVARKL
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60260 S127 SIGNOR|PSP PRKN PARK2 LsssVLPGDSVGLAVILHTDsRKDsPPAGsPAGRSIyNSFY
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75179 S2045 EPSD|PSP ANKRD17 GTAR KIAA0697 TNATYPMPTAKEHyPVssPssPsPPAQPGGVsRNsPLDCGs
O75179 S2047 EPSD|PSP ANKRD17 GTAR KIAA0697 ATYPMPTAKEHyPVssPssPsPPAQPGGVsRNsPLDCGsAs
O75385 S638 EPSD|PSP ULK1 KIAA0722 PPILGsPtKAVPSFDFPKtPssQNLLALLARQGVVMTPPRN
O75385 S758 SIGNOR|EPSD|PSP ULK1 KIAA0722 HPGARAGGtSSPSPVVFtVGsPPsGstPPQGPRTRMFsAGP
O95163 S1174 SIGNOR|PSP ELP1 IKAP IKBKAP DDEVPHGQESDLFsEtssVVsGSEMSGKYSHSNSRISARSS
O95747 S339 EPSD|PSP OXSR1 KIAA1101 OSR1 RRVPGssGRLHKtEDGGWEWsDDEFDEEsEEGKAAIsQLRs
O95757 S599 Sugiyama HSPA4L APG1 HSPH3 OSP94 sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND
O95817 S289 EPSD|PSP BAG3 BIS sVQGAssREGsPARsstPLHsPsPIRVHtVVDRPQQPMTHR
O95817 T285 EPSD|PSP BAG3 BIS PFRssVQGAssREGsPARsstPLHsPsPIRVHtVVDRPQQP
O96018 S7 EPSD|PSP APBA3 MINT3 X11L2 ______________MDFPtIsRsPsGPPAMDLEGPRDILVP
O96018 T5 EPSD|PSP APBA3 MINT3 X11L2 ________________MDFPtIsRsPsGPPAMDLEGPRDIL
P00441 T40 EPSD|PSP SOD1 NFEQKEsNGPVKVWGSIKGLtEGLHGFHVHEFGDNtAGCts
P01106 S77 PSP MYC BHLHE39 PPAPSEDIWKKFELLPtPPLsPsRRsGLCsPSyVAVTPFsL
P03372 S104 EPSD|PSP ESR1 ESR NR3A1 SEAAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPH
P03372 S106 EPSD|PSP ESR1 ESR NR3A1 AAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPHGQ
P03372 S118 PSP ESR1 ESR NR3A1 PPLNsVsPsPLMLLHPPPQLsPFLQPHGQQVPYYLENEPSG
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04198 S62 EPSD|PSP MYCN BHLHE37 NMYC STPPGEDIWKKFELLPtPPLsPsRGFAEHSSEPPSWVTEML
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S452 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10275 S96 PSP AR DHTR NR3C4 QQQQQETsPRQQQQQQGEDGsPQAHRRGPTGYLVLDEEQQP
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987 S544 Sugiyama TCP1 CCT1 CCTA ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P19484 S122 EPSD|PSP TFEB BHLHE35 NKFAAHIsPAQGsPKPPPAAsPGVRAGHVLSssAGNsAPNs
P19484 S142 SIGNOR TFEB BHLHE35 sPGVRAGHVLSssAGNsAPNsPMAMLHIGsNPERELDDVID
P19484 S211 SIGNOR|EPSD|PSP TFEB BHLHE35 LNVYSSDPQVTASLVGVTSSsCPADLTQKRELTDAESRALA
P23443 S394 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RPS6KB1 STK14A QsEEDVsQFDSKFtRQtPVDsPDDstLsEsANQVFLGFtYV
P23443 S434 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RPS6KB1 STK14A VAPSVLESVKEKFsFEPKIRsPRRFIGsPRtPVsPVKFsPG
P23443 S447 GPS6|ELM|iPTMNet|EPSD RPS6KB1 STK14A sFEPKIRsPRRFIGsPRtPVsPVKFsPGDFWGRGASASTAN
P23443 T390 GPS6|SIGNOR|ELM|iPTMNet|EPSD RPS6KB1 STK14A KPLLQsEEDVsQFDSKFtRQtPVDsPDDstLsEsANQVFLG
P23443 T412 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RPS6KB1 STK14A VDsPDDstLsEsANQVFLGFtYVAPSVLESVKEKFsFEPKI
P23443 T444 EPSD RPS6KB1 STK14A EKFsFEPKIRsPRRFIGsPRtPVsPVKFsPGDFWGRGASAS
P23921 S631 SIGNOR|PSP RRM1 RR1 LGNNESIEPYTSNIYTRRVLsGEFQIVNPHLLKDLTERGLW
P26358 S714 EPSD|PSP DNMT1 AIM CXXC9 DNMT MAMKEADDDEEVDDNIPEMPsPKKMHQGKKKKQNKNRIsWV
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27708 S1038 Sugiyama CAD QLPNNMAMALHRQQCRVLGtsPEAIDSAENRFKFSRLLDTI
P27797 S195 Sugiyama CALR CRTC IVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIKDPDAsK
P29966 S26 Sugiyama MARCKS MACS PRKCSL SKTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAs
P31749 S473 GPS6|SIGNOR|EPSD|PSP AKT1 PKB RAC DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P31749 S477 SIGNOR AKT1 PKB RAC SMECVDSERRPHFPQFsysAsGtA_________________
P31749 T450 SIGNOR|EPSD|PSP AKT1 PKB RAC TSETDTRYFDEEFtAQMItItPPDQDDSMECVDSERRPHFP
P31749 T479 SIGNOR AKT1 PKB RAC ECVDSERRPHFPQFsysAsGtA___________________
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35568 S307 SIGNOR IRS1 HHLNNPPPSQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVR
P35568 S312 SIGNOR IRS1 PPPSQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVRAssDG
P35568 S315 SIGNOR IRS1 SQVGLTRRsRtEsItAtsPAsMVGGKPGsFRVRAssDGEGt
P35568 S616 SIGNOR IRS1 GGHHRPDsstLHtDDGyMPMsPGVAPVPSGRKGsGDyMPMs
P35568 S636 SIGNOR|PSP IRS1 sPGVAPVPSGRKGsGDyMPMsPKsVSAPQQIINPIRRHPQR
P35568 S639 SIGNOR|PSP IRS1 VAPVPSGRKGsGDyMPMsPKsVSAPQQIINPIRRHPQRVDP
P35613 S279 Sugiyama BSG UNQ6505/PRO21383 TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40763 S727 SIGNOR STAT3 APRF KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P42345 S2159 EPSD MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 AVPGTYDPNQPIIRIQSIAPsLQVItSKQRPRKLTLMGSNG
P42345 S2448 PSP MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 NWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEPAH
P42345 S2454 EPSD|PSP MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 TNTKGNKRsRtRtDsYsAGQsVEILDGVELGEPAHKKtGtt
P42345 S2478 EPSD|PSP MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 LDGVELGEPAHKKtGttVPEsIHsFIGDGLVKPEALNKKAI
P42345 S2481 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 VELGEPAHKKtGttVPEsIHsFIGDGLVKPEALNKKAIQII
P42345 T2446 EPSD MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 LLNWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEP
P42345 T2473 EPSD|PSP MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 QsVEILDGVELGEPAHKKtGttVPEsIHsFIGDGLVKPEAL
P42345 T2474 EPSD|PSP MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 sVEILDGVELGEPAHKKtGttVPEsIHsFIGDGLVKPEALN
P46937 S436 SIGNOR|PSP YAP1 YAP65 FLNsVDEMDTGDTINQSTLPsQQNRFPDyLEAIPGTNVDLG
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P51397 S3 GPS6|SIGNOR|EPSD DAP DAP1 __________________MssPPEGKLETKAGHPPAVKAGG
P51397 S51 GPS6|SIGNOR|EPSD|PSP DAP DAP1 PHTGDTKEEKDKDDQEWEsPsPPKPtVFISGVIARGDKDFP
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55199 S309 EPSD|PSP ELL C19orf17 VRKLCQPQSTGSLLGDPAAssPPGERGRsAsPPQKRLQPPD
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62753 S235 PSP RPS6 OK/SW-cl.2 KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______
P62753 S236 PSP RPS6 OK/SW-cl.2 RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
Q00613 S303 PSP HSF1 HSTF1 SIDERPLSSsPLVRVKEEPPsPPQsPRVEEAsPGRPssVDt
Q00613 S326 EPSD|PSP HSF1 HSTF1 QsPRVEEAsPGRPssVDtLLsPtALIDsILREsEPAPAsVT
Q02156 S729 PSP PRKCE PKCE LtLVDEAIVKQINQEEFKGFsYFGEDLMP____________
Q02156 T566 PSP PRKCE PKCE CKLADFGMCKEGILNGVTTTtFCGTPDyIAPEILQELEYGP
Q02156 T710 SIGNOR|PSP PRKCE PKCE KTKRDVNNFDQDFtREEPVLtLVDEAIVKQINQEEFKGFsY
Q07820 S64 PSP MCL1 BCL2L3 ARREIGGGEAGAVIGGSAGAsPPstLtPDSRRVARPPPIGA
Q09161 T21 Sugiyama NCBP1 CBP80 NCBP MSRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEK
Q13322 S150 GPS6|EPSD GRB10 GRBIR KIAA0207 FRtssLPAIPNPFPELCGPGsPPVLtPGSLPPSQAAAKQDV
Q13322 S428 EPSD|PSP GRB10 GRBIR KIAA0207 RIPQQRKALLsPFstPVRsVsENsLVAMDFSGQTGRVIENP
Q13322 S476 GPS6|EPSD|PSP GRB10 GRBIR KIAA0207 LEEGHAWRKRSTRMNILGsQsPLHPstLSTVIHRTQHWFHG
Q13322 T155 EPSD|PSP GRB10 GRBIR KIAA0207 LPAIPNPFPELCGPGsPPVLtPGSLPPSQAAAKQDVKVFSE
Q13541 S101 GPS6|ELM|iPTMNet|EPSD EIF4EBP1 VtsPssDEPPMEAsQsHLRNsPEDKRAGGEEsQFEMDI___
Q13541 S44 EPSD|PSP EIF4EBP1 GDGVQLPPGDysttPGGtLFsttPGGtRIIyDRKFLMECRN
Q13541 S65 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF4EBP1 ttPGGtRIIyDRKFLMECRNsPVtKtPPRDLPtIPGVtsPs
Q13541 S83 GPS6|SIGNOR|ELM|iPTMNet|EPSD EIF4EBP1 RNsPVtKtPPRDLPtIPGVtsPssDEPPMEAsQsHLRNsPE
Q13541 T36 GPS6|SIGNOR EIF4EBP1 PATRRVVLGDGVQLPPGDysttPGGtLFsttPGGtRIIyDR
Q13541 T37 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF4EBP1 ATRRVVLGDGVQLPPGDysttPGGtLFsttPGGtRIIyDRK
Q13541 T41 EPSD|PSP EIF4EBP1 VVLGDGVQLPPGDysttPGGtLFsttPGGtRIIyDRKFLME
Q13541 T45 GPS6|SIGNOR EIF4EBP1 DGVQLPPGDysttPGGtLFsttPGGtRIIyDRKFLMECRNs
Q13541 T46 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF4EBP1 GVQLPPGDysttPGGtLFsttPGGtRIIyDRKFLMECRNsP
Q13541 T70 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF4EBP1 tRIIyDRKFLMECRNsPVtKtPPRDLPtIPGVtsPssDEPP
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q15652 T505 SIGNOR JMJD1C JHDM2C KIAA1380 TRIP8 MDKTHTMELLPKEKFVSRPPtPKCVIDItNDtNLEKVAQEN
Q16513 T958 PSP PKN2 PRK2 PRKCL2 RGREDVSNFDDEFtsEAPILtPPREPRILsEEEQEMFRDFD
Q5T4S7 S2932 EPSD|PSP UBR4 KIAA0462 KIAA1307 RBAF600 sGRSSAYGDATAEGHPAGPGsVSSSTGAISTTTGHQEGDGS
Q5VT52 S1180 Sugiyama RPRD2 KIAA0460 HSPC099 TGFKTAPYKERAPQFQEsVGsFRsNsFNstFEHHLPPsPLE
Q641Q2 S700 EPSD|PSP WASHC2A FAM21A FAM21B SQKKTQRVsLLFEDDVDsGGsLFGsPPtsVPPATKKKETVS
Q641Q2 S704 EPSD|PSP WASHC2A FAM21A FAM21B TQRVsLLFEDDVDsGGsLFGsPPtsVPPATKKKETVSEAPP
Q6GYQ0 S860 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 DEFIAERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQ
Q6PKG0 S766 EPSD|PSP LARP1 KIAA0731 LARP PtDALANKLFGAPEPstIARsLPttVPEsPNyRNtRtPRtP
Q6PKG0 S774 EPSD|PSP LARP1 KIAA0731 LARP LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZN18 S206 Sugiyama AEBP2 DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q86TB9 S179 EPSD|PSP PATL1 OK/KNS-cl.5 PQGPEDDRDLSERALPRRstsPIIGsPPVRAVPIGtPPKQM
Q86TB9 S184 EPSD|PSP PATL1 OK/KNS-cl.5 DDRDLSERALPRRstsPIIGsPPVRAVPIGtPPKQMAVPSF
Q8IYB3 T572 EPSD|PSP SRRM1 SRM160 PPPTRRRRsPsPAPPPRRRRtPtPPPRRRtPsPPPRRRSPS
Q8IYB3 T574 EPSD|PSP SRRM1 SRM160 PTRRRRsPsPAPPPRRRRtPtPPPRRRtPsPPPRRRSPSPR
Q8N122 S855 SIGNOR RPTOR KIAA1303 RAPTOR NSIAYKATVNARPQRVLDtssLtQsAPAsPtNKGVHIHQAG
Q8N122 S859 SIGNOR|EPSD|PSP RPTOR KIAA1303 RAPTOR YKATVNARPQRVLDtssLtQsAPAsPtNKGVHIHQAGGsPP
Q8N122 S863 SIGNOR|EPSD|PSP RPTOR KIAA1303 RAPTOR VNARPQRVLDtssLtQsAPAsPtNKGVHIHQAGGsPPAsst
Q8N1F8 S404 PSP STK11IP KIAA1898 LIP1 LKB1IP STK11IP1 RRASISEPSDTDPEPRTLNPsPAGWFVQQHPELELMSSFRE
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N3D4 S1257 Sugiyama EHBP1L1 EGLVNGAGAPGGGGVRLRRPsVNGEPGSVPPPRAHGsFsHV
Q8N3Y1 S85 SIGNOR FBXW8 FBW6 FBW8 FBX29 FBXO29 FBXW6 RPPAARATRAEGQDVASRSRsPLAREGAGGGEQLVDQLIRD
Q8NHG8 S145 EPSD|PSP ZNRF2 RNF202 GGGRDRPVGGsPGGPRLVIGsLPAHLsPHMFGGFKCPVCSK
Q8TB45 S265 EPSD|PSP DEPTOR DEPDC6 PFCLRKQSHDNRKstsFMsVsPsKEIKIVSAVRRssMssCG
Q8TB45 S286 EPSD|PSP DEPTOR DEPDC6 PsKEIKIVSAVRRssMssCGssGyFsssPtLsssPPVLCNP
Q8TB45 S293 SIGNOR|EPSD|PSP DEPTOR DEPDC6 VSAVRRssMssCGssGyFsssPtLsssPPVLCNPKSVLKRP
Q8TB45 S299 SIGNOR|EPSD|PSP DEPTOR DEPDC6 ssMssCGssGyFsssPtLsssPPVLCNPKSVLKRPVtsEEL
Q8TB45 T295 EPSD|PSP DEPTOR DEPDC6 AVRRssMssCGssGyFsssPtLsssPPVLCNPKSVLKRPVt
Q8TBX8 S324 SIGNOR|PSP PIP4K2C PIP5K2C EDESEVDGDCSLTGPPALVGsYGTsPEGIGGYIHSHRPLGP
Q8TBX8 S328 SIGNOR|PSP PIP4K2C PIP5K2C EVDGDCSLTGPPALVGsYGTsPEGIGGYIHSHRPLGPGEFE
Q96B36 S183 GPS6|SIGNOR|EPSD|PSP AKT1S1 PRAS40 GPPTCSVPPASALPTQQYAKsLPVSVPVWGFKEKRtEARss
Q96B36 S212 GPS6|SIGNOR AKT1S1 PRAS40 GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96B36 S221 SIGNOR|EPSD|PSP AKT1S1 PRAS40 RssDEENGPPssPDLDRIAAsMRALVLREAEDtQVFGDLPR
Q96F24 S113 SIGNOR|PSP NRBF2 COPR DAAAHLQTSHKPsAEDAEGQsPLsQKysPstEKCLPEIQGI
Q96F24 S120 SIGNOR|PSP NRBF2 COPR TSHKPsAEDAEGQsPLsQKysPstEKCLPEIQGIFDRDPDT
Q96KG9 S754 PSP SCYL1 CVAK90 GKLP NTKL TAPK TEIF TRAP HT019 DKGDPFAtLsARPstQPRPDsWGEDNWEGLETDSRQVKAEL
Q96RG2 S949 PSP PASK KIAA0135 VKDLLHsQRDsAARTRLFLAsLPGstHstAAELTGPSLVEV
Q96RG2 S953 PSP PASK KIAA0135 LHsQRDsAARTRLFLAsLPGstHstAAELTGPSLVEVLRAR
Q96RG2 S956 PSP PASK KIAA0135 QRDsAARTRLFLAsLPGstHstAAELTGPSLVEVLRARPWF
Q96RG2 T640 PSP PASK KIAA0135 WWRSQDLAPSPSGMAGLSFGtPtLDEPWLGVENDREELQTC
Q96RG2 T642 PSP PASK KIAA0135 RSQDLAPSPSGMAGLSFGtPtLDEPWLGVENDREELQTCLI
Q99497 S57 Sugiyama PARK7 GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q9BPZ7 S260 EPSD|PSP MAPKAP1 MIP1 SIN1 EVDTDFPPLDSNEPIHKFGFsTLALVEKYSsPGLTSKESLF
Q9BRS8 S348 SIGNOR|EPSD|PSP LARP6 QYMGDESSANSSSDPEsNPtsPMAGRRHAATNKLSPSGHQN
Q9BRS8 S409 SIGNOR|EPSD|PSP LARP6 RKGVSRKsPLAEEGRLNCstsPEIFRKCMDYSsDSSVTPSG
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C7 S52 SIGNOR|EPSD|PSP AMBRA1 DCAF3 KIAA1736 LVEDKTRWMKWEGKRVELPDsPRSTFLLAFSPDRTLLASTH
Q9H063 S60 GPS6|SIGNOR|EPSD|PSP MAF1 DKHMFKQFCQEGQPHVLEALsPPQtsGLsPsRLsKsQGGEE
Q9H063 S68 GPS6|SIGNOR|EPSD|PSP MAF1 CQEGQPHVLEALsPPQtsGLsPsRLsKsQGGEEEGPLSDKC
Q9H063 S75 GPS6|SIGNOR|EPSD|PSP MAF1 VLEALsPPQtsGLsPsRLsKsQGGEEEGPLSDKCSRKTLFY
Q9H1K1 S14 SIGNOR|EPSD|PSP ISCU NIFUN _______MAAAGAFRLRRAAsALLLRsPRLPARELsAPARL
Q9H4A3 S2032 EPSD|PSP WNK1 HSN2 KDP KIAA0344 PRKWNK1 sDPEAAFLSRDVDDGsGsPHsPHQLssKSLPSQNLSQSLSN
Q9H4L4 S139 PSP SENP3 SSP3 SUSP3 RKTCSQRRRRAMRAFRMLLYsKstsLtFHWKLWGRHRGRRR
Q9H4L4 S141 PSP SENP3 SSP3 SUSP3 TCSQRRRRAMRAFRMLLYsKstsLtFHWKLWGRHRGRRRGL
Q9H4L4 S143 PSP SENP3 SSP3 SUSP3 SQRRRRAMRAFRMLLYsKstsLtFHWKLWGRHRGRRRGLAH
Q9H4L4 S25 PSP SENP3 SSP3 SUSP3 IQGTGSWGPEPPGPGIPPAyssPRRERLRWPPPPKPRLKsG
Q9H4L4 S26 PSP SENP3 SSP3 SUSP3 QGTGSWGPEPPGPGIPPAyssPRRERLRWPPPPKPRLKsGG
Q9H4L4 T142 PSP SENP3 SSP3 SUSP3 CSQRRRRAMRAFRMLLYsKstsLtFHWKLWGRHRGRRRGLA
Q9H4L4 T145 PSP SENP3 SSP3 SUSP3 RRRRAMRAFRMLLYsKstsLtFHWKLWGRHRGRRRGLAHPK
Q9H5H4 S139 EPSD|PSP ZNF768 PRyEPQsPGYEPRsPGYEPRsPGYEsEssRYESQNTELKTQ
Q9H714 S157 PSP RUBCNL C13orf18 KIAA0226L VRPGYSHRVSLPTSPGILATsPYPETDSAFFEPSHLTSAAD
Q9H8M2 S588 EPSD|PSP BRD9 UNQ3040/PRO9856 sRLsVGEQPDVtHDPYEFLQsPEPAASAKT___________
Q9HB90 S21 PSP RRAGC MsLQyGAEEtPLAGsyGAADsFPKDFGYGVEEEEEEAAAAG
Q9HB90 T394 PSP RRAGC HRsCGHQtsAssLKALTHNGtPRNAI_______________
Q9HBH9 S74 SIGNOR|PSP MKNK2 GPRK7 MNK2 IDIPDAKKRGKKKKRGRAtDsFsGRFEDVYQLQEDVLGEGA
Q9NQG5 S166 EPSD|PSP RPRD1B C20orf77 CREPT LKRTFQQIQEEEDDDyPGsysPQDPsAGPLLTEELIKALQD
Q9P2Y5 S493 PSP UVRAG SAIPVPKRQssIFGGADVGFsGGIPsPDKGHRKRAssENER
Q9P2Y5 S498 PSP UVRAG PKRQssIFGGADVGFsGGIPsPDKGHRKRAssENERLQyKt
Q9P2Y5 S508 PSP UVRAG ADVGFsGGIPsPDKGHRKRAssENERLQyKtPPPsyNsALA
Q9P2Y5 S522 PSP UVRAG GHRKRAssENERLQyKtPPPsyNsALAQPVTTVPSMGETER
Q9P2Y5 S549 PSP UVRAG QPVTTVPSMGETERKITSLSssLDtsLDFSKENKKKGEDLV
Q9P2Y5 S550 SIGNOR|EPSD|PSP UVRAG PVTTVPSMGETERKITSLSssLDtsLDFSKENKKKGEDLVG
Q9P2Y5 S571 SIGNOR|EPSD|PSP UVRAG LDtsLDFSKENKKKGEDLVGsLNGGHANVHPsQEQGEALSG
Q9P2Y5 S582 PSP UVRAG KKKGEDLVGsLNGGHANVHPsQEQGEALSGHRATVNGTLLP
Q9UBS0 S370 SIGNOR|EPSD RPS6KB2 STK14B QSEEDVSQFDTRFTRQTPVDsPDDTALSESANQAFLGFtYV
Q9UBS0 T228 SIGNOR|EPSD RPS6KB2 STK14B IKLTDFGLCKESIHEGAVTHtFCGTIEYMAPEILVRSGHNR
Q9UBS0 T388 GPS6|SIGNOR|ELM|iPTMNet|EPSD RPS6KB2 STK14B VDsPDDTALSESANQAFLGFtYVAPSVLDSIKEGFsFQPKL
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UPY5 S26 SIGNOR|PSP SLC7A11 VVStISKGGyLQGNVNGRLPsLGNKEPPGQEKVQLKRKVTL
Q9UQ35 S1318 EPSD|PSP SRRM2 KIAA0324 SRL300 SRM300 HSPC075 VPsMASSWGGPHFsPEHKELsNsPLRENsFGsPLEFRNsGP
Q9UQ35 S1326 EPSD|PSP SRRM2 KIAA0324 SRL300 SRM300 HSPC075 GGPHFsPEHKELsNsPLRENsFGsPLEFRNsGPLGTEMNtG
Q9UQ35 S1329 EPSD|PSP SRRM2 KIAA0324 SRL300 SRM300 HSPC075 HFsPEHKELsNsPLRENsFGsPLEFRNsGPLGTEMNtGFss
Q9Y2J4 S759 SIGNOR|EPSD|PSP AMOTL2 KIAA0989 TCLPPEPDSLLGCSSSQRAAsLDsVATSRVQDLSDMVEILI
Q9Y6W6 S224 EPSD|PSP DUSP10 MKP5 RLQQGKITVLDLISCREGKDsFKRIFsKEIIVYDENTNEPS
Q9Y6W6 S230 EPSD|PSP DUSP10 MKP5 ITVLDLISCREGKDsFKRIFsKEIIVYDENTNEPSRVMPSQ
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Regulation of TP53 Activity R-HSA-5633007 0.000001 5.866 1 0
Cell Cycle R-HSA-1640170 0.000017 4.762 0 0
Chromatin organization R-HSA-4839726 0.000023 4.648 0 0
NRAGE signals death through JNK R-HSA-193648 0.000026 4.592 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000048 4.318 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.000055 4.263 0 0
Chromatin modifying enzymes R-HSA-3247509 0.000065 4.184 0 0
Cell Cycle, Mitotic R-HSA-69278 0.000074 4.130 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.000094 4.025 0 0
Death Receptor Signaling R-HSA-73887 0.000140 3.853 0 0
Apoptotic execution phase R-HSA-75153 0.000232 3.635 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.000256 3.592 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.000566 3.247 0 0
Gene expression (Transcription) R-HSA-74160 0.000549 3.260 1 0
Cell junction organization R-HSA-446728 0.000510 3.293 0 0
G alpha (12/13) signalling events R-HSA-416482 0.000534 3.272 0 0
Cell-Cell communication R-HSA-1500931 0.000649 3.188 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.000712 3.148 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.000717 3.145 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.000820 3.086 0 0
Signaling by ALK in cancer R-HSA-9700206 0.000820 3.086 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.000867 3.062 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.000902 3.045 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.000980 3.009 1 0
Polo-like kinase mediated events R-HSA-156711 0.001577 2.802 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.001577 2.802 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.001803 2.744 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.002183 2.661 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.002463 2.608 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.002716 2.566 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.002873 2.542 0 0
Signaling by ALK R-HSA-201556 0.003011 2.521 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.003167 2.499 0 0
TGFBR3 expression R-HSA-9839394 0.003551 2.450 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.004010 2.397 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.004054 2.392 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.003907 2.408 0 0
Centrosome maturation R-HSA-380287 0.004087 2.389 0 0
Signaling by Hippo R-HSA-2028269 0.004341 2.362 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.004734 2.325 0 0
RET signaling R-HSA-8853659 0.004696 2.328 0 0
G1/S-Specific Transcription R-HSA-69205 0.004696 2.328 0 0
HATs acetylate histones R-HSA-3214847 0.005042 2.297 0 0
Signal Transduction R-HSA-162582 0.005474 2.262 1 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.006317 2.200 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.006317 2.200 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.005874 2.231 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.006116 2.214 0 0
MTOR signalling R-HSA-165159 0.005924 2.227 1 1
Cell-cell junction organization R-HSA-421270 0.006317 2.200 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.006122 2.213 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.006799 2.168 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.006911 2.160 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.007332 2.135 0 0
RNA Polymerase II Transcription R-HSA-73857 0.007743 2.111 1 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.009008 2.045 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.009106 2.041 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.009106 2.041 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.009202 2.036 0 0
Neurodegenerative Diseases R-HSA-8863678 0.008620 2.065 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.008620 2.065 0 0
Mitotic Prometaphase R-HSA-68877 0.008889 2.051 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.009643 2.016 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.009643 2.016 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.009566 2.019 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 0.011311 1.946 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.011311 1.946 0 0
Repression of WNT target genes R-HSA-4641265 0.011061 1.956 0 0
Signaling by LTK R-HSA-9842663 0.011061 1.956 0 0
Adherens junctions interactions R-HSA-418990 0.011914 1.924 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.011496 1.939 0 0
G0 and Early G1 R-HSA-1538133 0.013560 1.868 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.012983 1.887 0 0
Calcineurin activates NFAT R-HSA-2025928 0.013081 1.883 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.014814 1.829 1 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.015927 1.798 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.015141 1.820 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.015927 1.798 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.018523 1.732 0 0
FOXO-mediated transcription R-HSA-9614085 0.017801 1.750 0 0
M Phase R-HSA-68886 0.018504 1.733 0 0
Nervous system development R-HSA-9675108 0.017694 1.752 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.018592 1.731 0 0
Regulation of KIT signaling R-HSA-1433559 0.018592 1.731 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.018743 1.727 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.019764 1.704 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.022424 1.649 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.022424 1.649 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.022424 1.649 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.022424 1.649 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 0.022424 1.649 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 0.022424 1.649 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.022424 1.649 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 0.022424 1.649 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.020328 1.692 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.021500 1.668 0 0
G1/S Transition R-HSA-69206 0.021651 1.665 0 0
Cellular Senescence R-HSA-2559583 0.024387 1.613 0 0
Signaling by TGFBR3 R-HSA-9839373 0.023912 1.621 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.024866 1.604 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.025428 1.595 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.025971 1.586 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.025971 1.586 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.026617 1.575 0 0
Signaling by ERBB2 R-HSA-1227986 0.027458 1.561 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.028189 1.550 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.028189 1.550 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.028361 1.547 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.028912 1.539 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.029142 1.535 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.032338 1.490 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.031645 1.500 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.032338 1.490 0 0
Cell Cycle Checkpoints R-HSA-69620 0.031562 1.501 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.033687 1.473 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.034013 1.468 0 0
G2/M Transition R-HSA-69275 0.034543 1.462 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.038796 1.411 0 0
Formation of annular gap junctions R-HSA-196025 0.038796 1.411 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.037967 1.421 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.037759 1.423 0 0
Generic Transcription Pathway R-HSA-212436 0.038066 1.419 1 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.038796 1.411 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.039344 1.405 0 0
Cellular response to heat stress R-HSA-3371556 0.041420 1.383 1 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.041736 1.379 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.041736 1.379 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.041736 1.379 1 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.042743 1.369 0 0
Axon guidance R-HSA-422475 0.042842 1.368 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.046941 1.328 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.044856 1.348 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.046845 1.329 0 0
Apoptosis R-HSA-109581 0.044666 1.350 0 0
NrCAM interactions R-HSA-447038 0.047301 1.325 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.047432 1.324 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.047432 1.324 0 0
Interleukin-6 signaling R-HSA-1059683 0.047432 1.324 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.050380 1.298 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.050380 1.298 0 0
Gap junction degradation R-HSA-190873 0.050380 1.298 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.051593 1.287 1 1
mRNA Splicing - Major Pathway R-HSA-72163 0.052735 1.278 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.054039 1.267 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.049608 1.304 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.050766 1.294 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.052565 1.279 0 0
FLT3 Signaling R-HSA-9607240 0.052565 1.279 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.055376 1.257 0 0
Oncogene Induced Senescence R-HSA-2559585 0.055376 1.257 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.057792 1.238 0 0
Activation of the pre-replicative complex R-HSA-68962 0.057829 1.238 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.057829 1.238 0 0
Activation of BH3-only proteins R-HSA-114452 0.057829 1.238 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.065073 1.187 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.065073 1.187 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.065073 1.187 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.058619 1.232 0 0
HIV Transcription Initiation R-HSA-167161 0.058619 1.232 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.058619 1.232 0 0
mRNA Splicing R-HSA-72172 0.062246 1.206 0 0
Signal attenuation R-HSA-74749 0.063653 1.196 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.065073 1.187 0 0
Trafficking of AMPA receptors R-HSA-399719 0.065484 1.184 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.065484 1.184 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.065484 1.184 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.107926 0.967 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 0.107926 0.967 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.077382 1.111 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.077382 1.111 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.077382 1.111 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.077382 1.111 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.077382 1.111 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.077382 1.111 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.077382 1.111 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.077382 1.111 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.077382 1.111 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.077382 1.111 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.077382 1.111 0 0
MGMT-mediated DNA damage reversal R-HSA-5657655 0.204209 0.690 0 0
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9036092 0.204209 0.690 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 0.204209 0.690 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 0.204209 0.690 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 0.112430 0.949 0 0
Regulation of gap junction activity R-HSA-191650 0.150662 0.822 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 0.150662 0.822 0 0
HCN channels R-HSA-1296061 0.150662 0.822 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 0.150662 0.822 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 0.150662 0.822 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 0.150662 0.822 0 0
Signaling by MAP2K mutants R-HSA-9652169 0.150662 0.822 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.150662 0.822 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 0.290105 0.537 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 0.290105 0.537 0 0
Defective GALE causes EDG R-HSA-5609977 0.290105 0.537 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 0.290105 0.537 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.290105 0.537 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.290105 0.537 0 0
IKBKB deficiency causes SCID R-HSA-5602636 0.290105 0.537 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.290105 0.537 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 0.290105 0.537 0 0
Defective VWF binding to collagen type I R-HSA-9845622 0.290105 0.537 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 0.290105 0.537 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 0.290105 0.537 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.108134 0.966 0 0
SOS-mediated signalling R-HSA-112412 0.108134 0.966 0 0
Disinhibition of SNARE formation R-HSA-114516 0.108134 0.966 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 0.190982 0.719 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 0.190982 0.719 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 0.190982 0.719 0 0
IRS activation R-HSA-74713 0.190982 0.719 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.190982 0.719 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 0.190982 0.719 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.132871 0.877 0 0
Type I hemidesmosome assembly R-HSA-446107 0.132871 0.877 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.132871 0.877 0 0
Anchoring fibril formation R-HSA-2214320 0.095058 1.022 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.113029 0.947 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.113029 0.947 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.113029 0.947 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.113029 0.947 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.113029 0.947 0 0
Disorders of Nervous System Development R-HSA-9697154 0.113029 0.947 0 0
Pervasive developmental disorders R-HSA-9005895 0.113029 0.947 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.113029 0.947 0 0
MAPK1 (ERK2) activation R-HSA-112411 0.159346 0.798 0 0
ALK mutants bind TKIs R-HSA-9700645 0.159346 0.798 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.232497 0.634 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.232497 0.634 0 0
PDE3B signalling R-HSA-165160 0.232497 0.634 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.232497 0.634 0 0
PKB-mediated events R-HSA-109703 0.232497 0.634 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 0.232497 0.634 0 0
Signalling to ERK5 R-HSA-198765 0.366735 0.436 0 0
MPS IIIC - Sanfilippo syndrome C R-HSA-2206291 0.366735 0.436 0 0
Regulation of cortical dendrite branching R-HSA-8985801 0.366735 0.436 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 0.366735 0.436 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 0.366735 0.436 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 0.366735 0.436 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 0.366735 0.436 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 0.366735 0.436 0 0
Disorders of Developmental Biology R-HSA-9675151 0.095518 1.020 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.132369 0.878 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.187253 0.728 0 0
MAPK3 (ERK1) activation R-HSA-110056 0.187253 0.728 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.110355 0.957 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.110355 0.957 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.092394 1.034 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.152956 0.815 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.152956 0.815 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.274477 0.561 0 0
G2/M DNA replication checkpoint R-HSA-69478 0.274477 0.561 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.077655 1.110 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.126232 0.899 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.126232 0.899 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.126232 0.899 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.216295 0.665 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.087778 1.057 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.174655 0.758 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.174655 0.758 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.143089 0.844 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.082590 1.083 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.082590 1.083 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.110143 0.958 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.246186 0.609 0 0
Activation of RAC1 R-HSA-428540 0.246186 0.609 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.246186 0.609 0 0
MECP2 regulates transcription factors R-HSA-9022707 0.316341 0.500 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.316341 0.500 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 0.316341 0.500 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 0.316341 0.500 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.435096 0.361 0 0
Axonal growth stimulation R-HSA-209563 0.435096 0.361 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 0.435096 0.361 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 0.435096 0.361 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.435096 0.361 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.435096 0.361 0 0
Invadopodia formation R-HSA-8941237 0.435096 0.361 0 0
MET activates PTPN11 R-HSA-8865999 0.435096 0.361 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.435096 0.361 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.072045 1.142 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.122356 0.912 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.122356 0.912 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.179460 0.746 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.179460 0.746 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.220829 0.656 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.220829 0.656 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.220829 0.656 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.220829 0.656 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.087258 1.059 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.276660 0.558 0 0
MAP2K and MAPK activation R-HSA-5674135 0.113636 0.944 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.179655 0.746 0 0
Regulation by c-FLIP R-HSA-3371378 0.357624 0.447 0 0
Dimerization of procaspase-8 R-HSA-69416 0.357624 0.447 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.357624 0.447 0 0
FGFR2 alternative splicing R-HSA-6803529 0.218847 0.660 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.307469 0.512 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.307469 0.512 0 0
Ephrin signaling R-HSA-3928664 0.269751 0.569 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.239462 0.621 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.075976 1.119 0 0
mRNA 3'-end processing R-HSA-72187 0.154443 0.811 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.260574 0.584 0 0
Deadenylation of mRNA R-HSA-429947 0.260574 0.584 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.294892 0.530 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.338389 0.471 0 0
Removal of the Flap Intermediate R-HSA-69166 0.338389 0.471 0 0
CASP8 activity is inhibited R-HSA-5218900 0.397964 0.400 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.496082 0.304 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.496082 0.304 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.496082 0.304 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.496082 0.304 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.165720 0.781 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.224670 0.648 0 0
Tight junction interactions R-HSA-420029 0.282096 0.550 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.282096 0.550 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.320309 0.494 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.320309 0.494 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.320309 0.494 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.320309 0.494 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.320309 0.494 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.166544 0.778 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.269825 0.569 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.369216 0.433 0 0
Erythropoietin activates RAS R-HSA-9027284 0.369216 0.433 0 0
Translesion synthesis by REV1 R-HSA-110312 0.369216 0.433 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.303942 0.517 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.345876 0.461 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.345876 0.461 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.437083 0.359 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.437083 0.359 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 0.437083 0.359 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.326028 0.487 0 0
Translesion synthesis by POLI R-HSA-5656121 0.399773 0.398 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.399773 0.398 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.399773 0.398 0 0
snRNP Assembly R-HSA-191859 0.240860 0.618 0 0
Metabolism of non-coding RNA R-HSA-194441 0.240860 0.618 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.293141 0.533 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.371476 0.430 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.254456 0.594 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.348271 0.458 0 0
RAF activation R-HSA-5673000 0.328415 0.484 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.328415 0.484 0 0
HDACs deacetylate histones R-HSA-3214815 0.296418 0.528 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.370592 0.431 0 0
Notch-HLH transcription pathway R-HSA-350054 0.396999 0.401 0 0
Translesion synthesis by POLK R-HSA-5655862 0.429902 0.367 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.474776 0.324 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.474776 0.324 0 0
Signaling by APC mutants R-HSA-4839744 0.474776 0.324 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.474776 0.324 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.474776 0.324 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.474776 0.324 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 0.550487 0.259 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.550487 0.259 0 0
G2 Phase R-HSA-68911 0.550487 0.259 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 0.550487 0.259 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 0.550487 0.259 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 0.550487 0.259 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.550487 0.259 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.227394 0.643 0 0
HSF1 activation R-HSA-3371511 0.368353 0.434 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.392917 0.406 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.422344 0.374 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.422344 0.374 0 0
HSF1-dependent transactivation R-HSA-3371571 0.362231 0.441 1 1
Processing of DNA double-strand break ends R-HSA-5693607 0.321754 0.492 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.379225 0.421 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.447420 0.349 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 0.510894 0.292 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.510894 0.292 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.510894 0.292 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.396261 0.402 0 0
GAB1 signalosome R-HSA-180292 0.488353 0.311 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.488353 0.311 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.488353 0.311 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.420534 0.376 0 0
Attenuation phase R-HSA-3371568 0.448339 0.348 0 0
Striated Muscle Contraction R-HSA-390522 0.480903 0.318 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.516464 0.287 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.516464 0.287 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.545339 0.263 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.545339 0.263 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 0.545339 0.263 0 0
IRAK1 recruits IKK complex R-HSA-937039 0.545339 0.263 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.545339 0.263 0 0
Scavenging by Class F Receptors R-HSA-3000484 0.545339 0.263 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.545339 0.263 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.545339 0.263 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.545339 0.263 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.545339 0.263 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 0.599021 0.223 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.599021 0.223 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.599021 0.223 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.599021 0.223 0 0
Phosphorylation of Emi1 R-HSA-176417 0.599021 0.223 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.520248 0.284 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.520248 0.284 0 0
Packaging Of Telomere Ends R-HSA-171306 0.520248 0.284 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.543508 0.265 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.543508 0.265 0 0
HIV elongation arrest and recovery R-HSA-167287 0.543508 0.265 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.543508 0.265 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 0.578050 0.238 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.578050 0.238 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.578050 0.238 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.578050 0.238 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.578050 0.238 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 0.570065 0.244 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.570065 0.244 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.545536 0.263 1 1
Signaling by Erythropoietin R-HSA-9006335 0.566172 0.247 0 0
Late endosomal microautophagy R-HSA-9615710 0.566172 0.247 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.566172 0.247 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.588199 0.230 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.595445 0.225 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.595445 0.225 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.595445 0.225 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.595445 0.225 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.116052 0.935 0 0
Transcription of the HIV genome R-HSA-167172 0.166544 0.778 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.087987 1.056 0 0
Signaling by NOTCH3 R-HSA-9012852 0.296418 0.528 0 0
RNA Polymerase III Transcription R-HSA-74158 0.224670 0.648 0 0
Integrin signaling R-HSA-354192 0.162851 0.788 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.122356 0.912 0 0
EGFR downregulation R-HSA-182971 0.250883 0.601 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.152058 0.818 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.303942 0.517 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.389041 0.410 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.532525 0.274 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.532525 0.274 0 0
IGF1R signaling cascade R-HSA-2428924 0.206387 0.685 0 0
Aggrephagy R-HSA-9646399 0.094432 1.025 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.156976 0.804 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.532525 0.274 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.188133 0.726 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.392917 0.406 0 0
Crosslinking of collagen fibrils R-HSA-2243919 0.516464 0.287 0 0
Insulin receptor signalling cascade R-HSA-74751 0.578022 0.238 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.187253 0.728 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.069462 1.158 0 0
DARPP-32 events R-HSA-180024 0.214243 0.669 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.530429 0.275 0 0
DNA Damage Bypass R-HSA-73893 0.328509 0.483 0 0
mRNA Capping R-HSA-72086 0.566172 0.247 0 0
MET activates RAS signaling R-HSA-8851805 0.113029 0.947 0 0
Regulation of CDH11 function R-HSA-9762292 0.187253 0.728 0 0
Telomere Extension By Telomerase R-HSA-171319 0.348271 0.458 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.247647 0.606 0 0
Chromosome Maintenance R-HSA-73886 0.577022 0.239 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.077655 1.110 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.263093 0.580 0 0
IRS-mediated signalling R-HSA-112399 0.611658 0.213 0 0
Telomere Maintenance R-HSA-157579 0.576503 0.239 0 0
mTORC1-mediated signalling R-HSA-166208 0.104964 0.979 1 1
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.221486 0.655 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.468067 0.330 1 1
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.316341 0.500 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.122356 0.912 1 1
Signaling downstream of RAS mutants R-HSA-9649948 0.095539 1.020 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.095539 1.020 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.095539 1.020 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.113636 0.944 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.074466 1.128 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.117828 0.929 0 0
Extension of Telomeres R-HSA-180786 0.497636 0.303 0 0
DNA Double Strand Break Response R-HSA-5693606 0.156456 0.806 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.068250 1.166 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.383807 0.416 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.218482 0.661 0 0
Formation of the posterior neural plate R-HSA-9832991 0.216295 0.665 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.082590 1.083 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.123931 0.907 1 1
G2/M DNA damage checkpoint R-HSA-69473 0.093173 1.031 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.397964 0.400 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.209246 0.679 0 0
Meiotic synapsis R-HSA-1221632 0.396261 0.402 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.487600 0.312 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.563736 0.249 0 0
Interleukin-15 signaling R-HSA-8983432 0.276660 0.558 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.121462 0.916 0 0
EPH-Ephrin signaling R-HSA-2682334 0.497931 0.303 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.358839 0.445 0 0
Regulation of TP53 Expression R-HSA-6804754 0.077382 1.111 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.078569 1.105 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.190982 0.719 0 0
Signaling by EGFR R-HSA-177929 0.068166 1.166 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.068582 1.164 0 0
PI3K/AKT activation R-HSA-198203 0.437083 0.359 0 0
Homology Directed Repair R-HSA-5693538 0.184979 0.733 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.310018 0.509 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.447420 0.349 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.338219 0.471 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.603073 0.220 0 0
Mitotic Prophase R-HSA-68875 0.141427 0.849 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.130551 0.884 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.269751 0.569 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.232336 0.634 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.119183 0.924 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.370592 0.431 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.392917 0.406 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.523293 0.281 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.113029 0.947 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.082590 1.083 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.192762 0.715 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.397964 0.400 0 0
Activation of SMO R-HSA-5635838 0.399773 0.398 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.598691 0.223 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.369392 0.433 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.374724 0.426 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.374724 0.426 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.374724 0.426 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.374724 0.426 0 0
Adipogenesis R-HSA-9843745 0.325369 0.488 0 0
Nucleotide Excision Repair R-HSA-5696398 0.576579 0.239 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.132871 0.877 0 0
Formation of axial mesoderm R-HSA-9796292 0.132369 0.878 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.246186 0.609 0 0
Adrenoceptors R-HSA-390696 0.357624 0.447 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 0.307469 0.512 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.397964 0.400 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.496082 0.304 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.138595 0.858 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.369216 0.433 0 0
G2/M Checkpoints R-HSA-69481 0.275202 0.560 0 0
Translesion Synthesis by POLH R-HSA-110320 0.516464 0.287 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.545339 0.263 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.520248 0.284 0 0
Separation of Sister Chromatids R-HSA-2467813 0.423555 0.373 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.523293 0.281 0 0
Meiosis R-HSA-1500620 0.494370 0.306 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.357831 0.446 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.113636 0.944 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.437299 0.359 0 0
Interleukin-6 family signaling R-HSA-6783589 0.260574 0.584 0 0
Nuclear RNA decay R-HSA-9930044 0.162851 0.788 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.303942 0.517 0 0
Signaling by NOTCH R-HSA-157118 0.235860 0.627 0 0
Mitotic Anaphase R-HSA-68882 0.186634 0.729 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.069864 1.156 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.198655 0.702 0 0
RNA Polymerase I Transcription R-HSA-73864 0.394567 0.404 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.545339 0.263 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 0.578050 0.238 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.078718 1.104 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.308604 0.511 0 0
Semaphorin interactions R-HSA-373755 0.119425 0.923 0 0
TNF signaling R-HSA-75893 0.068166 1.166 0 0
DAP12 signaling R-HSA-2424491 0.392917 0.406 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.092042 1.036 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.358839 0.445 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.366051 0.436 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.192805 0.715 0 0
Frs2-mediated activation R-HSA-170968 0.307469 0.512 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.177538 0.751 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.371476 0.430 0 0
Rab regulation of trafficking R-HSA-9007101 0.427848 0.369 0 0
Neurexins and neuroligins R-HSA-6794361 0.251571 0.599 0 0
GPVI-mediated activation cascade R-HSA-114604 0.543917 0.264 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.112380 0.949 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.328997 0.483 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.357840 0.446 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 0.190982 0.719 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.190982 0.719 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.187253 0.728 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.069462 1.158 0 0
PTK6 Expression R-HSA-8849473 0.316341 0.500 0 0
Signaling by RAS mutants R-HSA-6802949 0.095539 1.020 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.123988 0.907 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.496082 0.304 0 0
TNFR1-mediated ceramide production R-HSA-5626978 0.496082 0.304 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.289101 0.539 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.437083 0.359 0 0
Activation of AKT2 R-HSA-165158 0.550487 0.259 0 0
PTK6 Down-Regulation R-HSA-8849472 0.550487 0.259 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.459466 0.338 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.480903 0.318 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.608843 0.215 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.258451 0.588 0 0
Circadian clock R-HSA-9909396 0.335691 0.474 0 0
Membrane Trafficking R-HSA-199991 0.171403 0.766 0 0
G1 Phase R-HSA-69236 0.383807 0.416 0 0
Cyclin D associated events in G1 R-HSA-69231 0.383807 0.416 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.480903 0.318 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.374724 0.426 0 0
DNA Repair R-HSA-73894 0.108710 0.964 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.289101 0.539 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.516464 0.287 0 0
Signaling by FGFR R-HSA-190236 0.589114 0.230 0 0
Interleukin-2 signaling R-HSA-9020558 0.474776 0.324 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.496441 0.304 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.113029 0.947 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.307469 0.512 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.369216 0.433 0 0
Ub-specific processing proteases R-HSA-5689880 0.437388 0.359 0 0
Diseases of programmed cell death R-HSA-9645723 0.225401 0.647 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.148394 0.829 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.282380 0.549 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.340504 0.468 0 0
Signaling by FGFR2 R-HSA-5654738 0.423208 0.373 0 0
Signaling by MET R-HSA-6806834 0.212675 0.672 0 0
PTEN Regulation R-HSA-6807070 0.514381 0.289 1 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.152956 0.815 0 0
FasL/ CD95L signaling R-HSA-75157 0.435096 0.361 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 0.338389 0.471 0 0
Lipophagy R-HSA-9613354 0.397964 0.400 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.496082 0.304 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.496082 0.304 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.303942 0.517 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.459466 0.338 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.510894 0.292 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.314801 0.502 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 0.599021 0.223 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 0.599021 0.223 0 0
Signalling to RAS R-HSA-167044 0.570065 0.244 0 0
Mismatch Repair R-HSA-5358508 0.488353 0.311 0 0
ESR-mediated signaling R-HSA-8939211 0.404167 0.393 0 0
Signaling by FGFR4 R-HSA-5654743 0.525921 0.279 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.098612 1.006 0 0
Negative regulation of MET activity R-HSA-6807004 0.160857 0.794 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.396999 0.401 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.355373 0.449 0 0
Signaling by NODAL R-HSA-1181150 0.543722 0.265 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 0.578050 0.238 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.228116 0.642 1 0
TCF dependent signaling in response to WNT R-HSA-201681 0.175061 0.757 0 0
Interleukin-7 signaling R-HSA-1266695 0.147566 0.831 0 0
Interleukin-35 Signalling R-HSA-8984722 0.545339 0.263 0 0
Autophagy R-HSA-9612973 0.202860 0.693 1 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.274477 0.561 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.357624 0.447 0 0
Rap1 signalling R-HSA-392517 0.294892 0.530 0 0
Vasopressin-like receptors R-HSA-388479 0.496082 0.304 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.369216 0.433 0 0
Myogenesis R-HSA-525793 0.303942 0.517 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.468067 0.330 0 0
MAPK family signaling cascades R-HSA-5683057 0.393061 0.406 0 0
DNA Damage Reversal R-HSA-73942 0.369216 0.433 0 0
Signaling by FGFR3 R-HSA-5654741 0.563028 0.249 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.159346 0.798 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.459466 0.338 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.516464 0.287 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.523197 0.281 0 0
Cleavage of the damaged purine R-HSA-110331 0.564110 0.249 0 0
Signaling by WNT R-HSA-195721 0.237306 0.625 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.480258 0.319 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.069161 1.160 0 0
Signaling by FGFR1 R-HSA-5654736 0.595607 0.225 0 0
Signaling by TGFB family members R-HSA-9006936 0.174434 0.758 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.195820 0.708 0 0
Signaling by NOTCH1 R-HSA-1980143 0.257602 0.589 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 0.545339 0.263 0 0
Apoptotic factor-mediated response R-HSA-111471 0.488353 0.311 0 0
Signaling by VEGF R-HSA-194138 0.339153 0.470 1 0
Ion homeostasis R-HSA-5578775 0.311799 0.506 0 0
Depurination R-HSA-73927 0.583838 0.234 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.114483 0.941 1 0
Macroautophagy R-HSA-1632852 0.272021 0.565 1 1
Programmed Cell Death R-HSA-5357801 0.126079 0.899 0 0
SDK interactions R-HSA-373756 0.204209 0.690 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 0.112430 0.949 0 0
MTF1 activates gene expression R-HSA-5660489 0.150662 0.822 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 0.150662 0.822 0 0
Transport of connexins along the secretory pathway R-HSA-190827 0.290105 0.537 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 0.290105 0.537 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.126232 0.899 0 0
Negative regulation of FLT3 R-HSA-9706369 0.197327 0.705 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.246186 0.609 0 0
Regulation of PTEN localization R-HSA-8948747 0.316341 0.500 0 0
MET interacts with TNS proteins R-HSA-8875513 0.435096 0.361 0 0
Regulation of IFNG signaling R-HSA-877312 0.276660 0.558 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.135700 0.867 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.269751 0.569 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.192762 0.715 0 0
Unwinding of DNA R-HSA-176974 0.397964 0.400 0 0
Alanine metabolism R-HSA-8964540 0.496082 0.304 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 0.496082 0.304 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.437083 0.359 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.263093 0.580 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.308651 0.511 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.399773 0.398 0 0
Differentiation of T cells R-HSA-9945266 0.399773 0.398 0 0
Kinesins R-HSA-983189 0.254456 0.594 0 0
Collagen degradation R-HSA-1442490 0.268304 0.571 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.268304 0.571 0 0
Platelet calcium homeostasis R-HSA-418360 0.370592 0.431 0 0
Ionotropic activity of kainate receptors R-HSA-451306 0.474776 0.324 0 0
Reelin signalling pathway R-HSA-8866376 0.550487 0.259 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.550487 0.259 0 0
Signaling by AXIN mutants R-HSA-4839735 0.510894 0.292 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.510894 0.292 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.437299 0.359 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.488353 0.311 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.472144 0.326 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 0.545339 0.263 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 0.545339 0.263 0 0
TRAIL signaling R-HSA-75158 0.599021 0.223 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.599021 0.223 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.599021 0.223 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.595492 0.225 0 0
Cargo concentration in the ER R-HSA-5694530 0.609558 0.215 0 0
Deubiquitination R-HSA-5688426 0.103539 0.985 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.577737 0.238 0 0
NGF-stimulated transcription R-HSA-9031628 0.195820 0.708 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.270194 0.568 0 0
Signaling by FGFR in disease R-HSA-1226099 0.337814 0.471 0 0
Cilium Assembly R-HSA-5617833 0.285768 0.544 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.310018 0.509 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.289101 0.539 0 0
Prolonged ERK activation events R-HSA-169893 0.399773 0.398 0 0
Cellular responses to stress R-HSA-2262752 0.500413 0.301 1 0
RUNX2 regulates bone development R-HSA-8941326 0.123931 0.907 0 0
Signalling to ERKs R-HSA-187687 0.348335 0.458 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.338389 0.471 0 0
Selective autophagy R-HSA-9663891 0.225401 0.647 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.396999 0.401 0 0
HIV Life Cycle R-HSA-162587 0.154740 0.810 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.468067 0.330 0 0
UCH proteinases R-HSA-5689603 0.490433 0.309 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.609875 0.215 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.285017 0.545 0 0
Interleukin-27 signaling R-HSA-9020956 0.437083 0.359 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.347174 0.459 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.082590 1.083 0 0
Ca2+ pathway R-HSA-4086398 0.221486 0.655 0 0
L1CAM interactions R-HSA-373760 0.416106 0.381 0 0
Signaling by PTK6 R-HSA-8848021 0.296661 0.528 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.296661 0.528 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.159346 0.798 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.437083 0.359 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.237234 0.625 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.232003 0.635 0 0
DCC mediated attractive signaling R-HSA-418885 0.069161 1.160 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 0.246186 0.609 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.121462 0.916 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.282750 0.549 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.495021 0.305 1 1
Base Excision Repair R-HSA-73884 0.247290 0.607 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.384004 0.416 0 0
Signaling by NTRKs R-HSA-166520 0.270361 0.568 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 0.232497 0.634 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 0.232497 0.634 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.092042 1.036 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 0.357624 0.447 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.162851 0.788 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 0.397964 0.400 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.369216 0.433 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.258246 0.588 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.254456 0.594 1 1
Heme signaling R-HSA-9707616 0.282380 0.549 0 0
S Phase R-HSA-69242 0.202940 0.693 0 0
DNA strand elongation R-HSA-69190 0.437299 0.359 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 0.599021 0.223 0 0
Processing of SMDT1 R-HSA-8949664 0.578050 0.238 0 0
p75NTR signals via NF-kB R-HSA-193639 0.369216 0.433 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.408466 0.389 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.108134 0.966 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.338389 0.471 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.179655 0.746 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.135229 0.869 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.459466 0.338 0 0
Lagging Strand Synthesis R-HSA-69186 0.570065 0.244 0 0
Tie2 Signaling R-HSA-210993 0.269751 0.569 0 0
DAG and IP3 signaling R-HSA-1489509 0.563028 0.249 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.187654 0.727 0 0
NADE modulates death signalling R-HSA-205025 0.150662 0.822 0 0
Oligomerization of connexins into connexons R-HSA-190704 0.290105 0.537 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.232497 0.634 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 0.246186 0.609 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 0.316341 0.500 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 0.435096 0.361 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 0.435096 0.361 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.179460 0.746 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.276660 0.558 0 0
Regulation of the apoptosome activity R-HSA-9627069 0.437083 0.359 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.371476 0.430 0 0
Metalloprotease DUBs R-HSA-5689901 0.496441 0.304 0 0
The NLRP3 inflammasome R-HSA-844456 0.516464 0.287 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.371476 0.430 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.562527 0.250 0 0
Nephrin family interactions R-HSA-373753 0.320309 0.494 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.402179 0.396 0 0
Calmodulin induced events R-HSA-111933 0.543917 0.264 0 0
Formation of apoptosome R-HSA-111458 0.437083 0.359 0 0
Netrin-1 signaling R-HSA-373752 0.247366 0.607 0 0
CaM pathway R-HSA-111997 0.543917 0.264 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.274477 0.561 0 0
Histamine receptors R-HSA-390650 0.435096 0.361 0 0
Nuclear import of Rev protein R-HSA-180746 0.102089 0.991 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.130815 0.883 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.208486 0.681 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.397964 0.400 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.369216 0.433 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.256385 0.591 0 0
PECAM1 interactions R-HSA-210990 0.474776 0.324 0 0
tRNA processing in the nucleus R-HSA-6784531 0.406636 0.391 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.554067 0.256 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.562810 0.250 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.351887 0.454 0 0
MHC class II antigen presentation R-HSA-2132295 0.307455 0.512 0 0
Formation of the anterior neural plate R-HSA-9823739 0.369216 0.433 0 0
Diseases of DNA repair R-HSA-9675135 0.279106 0.554 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.209937 0.678 0 0
Signaling by SCF-KIT R-HSA-1433557 0.231959 0.635 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 0.366735 0.436 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 0.435096 0.361 0 0
Fibronectin matrix formation R-HSA-1566977 0.220829 0.656 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.174178 0.759 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.174178 0.759 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.187984 0.726 0 0
Collagen chain trimerization R-HSA-8948216 0.241271 0.617 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 0.437083 0.359 0 0
Co-inhibition by BTLA R-HSA-9927353 0.550487 0.259 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.488353 0.311 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 0.599021 0.223 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.506896 0.295 0 0
Gene Silencing by RNA R-HSA-211000 0.491784 0.308 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.595445 0.225 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.418950 0.378 0 0
Depyrimidination R-HSA-73928 0.506896 0.295 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.328415 0.484 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.345876 0.461 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.399773 0.398 0 0
Other interleukin signaling R-HSA-449836 0.516464 0.287 0 0
Sensory processing of sound R-HSA-9659379 0.408882 0.388 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.114003 0.943 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.126232 0.899 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.570065 0.244 0 0
Growth hormone receptor signaling R-HSA-982772 0.422344 0.374 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 0.316341 0.500 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.148012 0.830 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 0.397964 0.400 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 0.399773 0.398 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.399773 0.398 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.279106 0.554 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.480903 0.318 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.543722 0.265 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.528275 0.277 0 0
Assembly Of The HIV Virion R-HSA-175474 0.595445 0.225 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.606033 0.218 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.383807 0.416 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.546527 0.262 0 0
Glycolysis R-HSA-70171 0.501187 0.300 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.160845 0.794 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.480903 0.318 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 0.599021 0.223 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.459466 0.338 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.595445 0.225 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 0.474776 0.324 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.550487 0.259 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 0.599021 0.223 0 0
OAS antiviral response R-HSA-8983711 0.545339 0.263 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.402686 0.395 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.447309 0.349 0 0
IRE1alpha activates chaperones R-HSA-381070 0.484463 0.315 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.429902 0.367 0 0
Signaling by Leptin R-HSA-2586552 0.437083 0.359 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.437083 0.359 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.619826 0.208 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.619826 0.208 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.619826 0.208 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 0.619826 0.208 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.619826 0.208 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.619826 0.208 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.619826 0.208 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.621791 0.206 0 0
HIV Transcription Elongation R-HSA-167169 0.621791 0.206 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.621791 0.206 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.621791 0.206 0 0
Interleukin-2 family signaling R-HSA-451927 0.621791 0.206 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.621791 0.206 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.621791 0.206 0 0
Cellular responses to stimuli R-HSA-8953897 0.624686 0.204 1 0
Mitochondrial biogenesis R-HSA-1592230 0.633766 0.198 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.637740 0.195 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.638189 0.195 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.638189 0.195 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.638189 0.195 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.638189 0.195 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.639972 0.194 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 0.642317 0.192 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 0.642317 0.192 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.642317 0.192 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.642317 0.192 0 0
Hydrolysis of LPE R-HSA-1483152 0.642317 0.192 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 0.642317 0.192 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 0.642317 0.192 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.642317 0.192 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 0.642317 0.192 0 0
Neurofascin interactions R-HSA-447043 0.642317 0.192 0 0
CREB phosphorylation R-HSA-199920 0.642317 0.192 0 0
NADPH regeneration R-HSA-389542 0.642317 0.192 0 0
HDL clearance R-HSA-8964011 0.642317 0.192 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.643188 0.192 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.643188 0.192 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.643188 0.192 0 0
PI3K Cascade R-HSA-109704 0.649100 0.188 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.649624 0.187 0 0
Post NMDA receptor activation events R-HSA-438064 0.656148 0.183 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.657599 0.182 0 0
Inositol phosphate metabolism R-HSA-1483249 0.658014 0.182 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.660481 0.180 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.665516 0.177 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.665516 0.177 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.665636 0.177 0 0
Phosphorylation of the APC/C R-HSA-176412 0.665636 0.177 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.665636 0.177 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.665636 0.177 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.665746 0.177 0 0
Ca-dependent events R-HSA-111996 0.674662 0.171 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.676116 0.170 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.680470 0.167 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.680470 0.167 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.680941 0.167 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 0.680941 0.167 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.680941 0.167 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 0.680941 0.167 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 0.680941 0.167 0 0
Recycling of eIF2:GDP R-HSA-72731 0.680941 0.167 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 0.680941 0.167 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.680941 0.167 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 0.680941 0.167 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.680941 0.167 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 0.680941 0.167 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.680941 0.167 0 0
Reuptake of GABA R-HSA-888593 0.680941 0.167 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.680941 0.167 0 0
VLDL clearance R-HSA-8964046 0.680941 0.167 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 0.680941 0.167 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 0.680941 0.167 0 0
CHL1 interactions R-HSA-447041 0.680941 0.167 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.686807 0.163 0 0
Long-term potentiation R-HSA-9620244 0.686807 0.163 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.686807 0.163 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.686807 0.163 0 0
Laminin interactions R-HSA-3000157 0.686807 0.163 0 0
HDMs demethylate histones R-HSA-3214842 0.686807 0.163 0 0
Signaling by NOTCH2 R-HSA-1980145 0.687861 0.162 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.687861 0.162 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.687861 0.162 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.687861 0.162 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.689087 0.162 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.691150 0.160 0 0
TBC/RABGAPs R-HSA-8854214 0.691150 0.160 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.691376 0.160 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.691376 0.160 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.691376 0.160 0 0
Response to metal ions R-HSA-5660526 0.691376 0.160 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.695454 0.158 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.695768 0.158 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.700235 0.155 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.705595 0.151 0 0
DAP12 interactions R-HSA-2172127 0.707058 0.151 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.707066 0.151 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.707066 0.151 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.707066 0.151 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.713621 0.147 0 0
Ion transport by P-type ATPases R-HSA-936837 0.713621 0.147 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 0.715396 0.145 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.715396 0.145 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 0.715396 0.145 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 0.715396 0.145 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.715396 0.145 0 0
MET receptor recycling R-HSA-8875656 0.715396 0.145 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.715396 0.145 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 0.715396 0.145 0 0
Interleukin-9 signaling R-HSA-8985947 0.715396 0.145 0 0
FGFR1b ligand binding and activation R-HSA-190370 0.715396 0.145 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.715396 0.145 0 0
TGFBR3 PTM regulation R-HSA-9839383 0.715396 0.145 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.715396 0.145 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.715459 0.145 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.715459 0.145 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.715459 0.145 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 0.715459 0.145 0 0
Specification of primordial germ cells R-HSA-9827857 0.715459 0.145 0 0
Signaling by NOTCH4 R-HSA-9013694 0.717692 0.144 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.721809 0.142 1 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.721977 0.141 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.722586 0.141 0 0
FLT3 signaling in disease R-HSA-9682385 0.722586 0.141 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.723988 0.140 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.726304 0.139 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.726304 0.139 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.726304 0.139 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.726304 0.139 1 1
Signaling by FGFR3 in disease R-HSA-5655332 0.726304 0.139 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.726304 0.139 0 0
Glucose metabolism R-HSA-70326 0.730114 0.137 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.733346 0.135 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.737535 0.132 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 0.737941 0.132 0 0
Nephron development R-HSA-9831926 0.737941 0.132 0 0
Voltage gated Potassium channels R-HSA-1296072 0.738837 0.131 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.739566 0.131 1 0
Vesicle-mediated transport R-HSA-5653656 0.739688 0.131 0 0
PI Metabolism R-HSA-1483255 0.740957 0.130 0 0
Pyrimidine salvage R-HSA-73614 0.744537 0.128 0 0
Inflammasomes R-HSA-622312 0.744537 0.128 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.746131 0.127 0 0
Interleukin-21 signaling R-HSA-9020958 0.746131 0.127 0 0
WNT mediated activation of DVL R-HSA-201688 0.746131 0.127 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 0.746131 0.127 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.746131 0.127 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.746131 0.127 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.746131 0.127 0 0
Regulation of signaling by NODAL R-HSA-1433617 0.746131 0.127 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.746131 0.127 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 0.746131 0.127 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.746131 0.127 0 0
Collagen formation R-HSA-1474290 0.747540 0.126 0 0
Regulation of CDH1 Function R-HSA-9764561 0.750600 0.125 0 0
Recycling pathway of L1 R-HSA-437239 0.751287 0.124 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.752942 0.123 0 0
HIV Infection R-HSA-162906 0.754305 0.122 0 0
MET promotes cell motility R-HSA-8875878 0.754357 0.122 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.754357 0.122 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.755033 0.122 0 0
Regulation of signaling by CBL R-HSA-912631 0.758888 0.120 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.758888 0.120 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.758888 0.120 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.758888 0.120 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.758888 0.120 0 0
Specification of the neural plate border R-HSA-9834899 0.758888 0.120 0 0
Maturation of nucleoprotein R-HSA-9694631 0.758888 0.120 0 0
Opioid Signalling R-HSA-111885 0.760520 0.119 0 0
DNA methylation R-HSA-5334118 0.761787 0.118 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.761787 0.118 0 0
Regulated Necrosis R-HSA-5218859 0.763076 0.117 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.763186 0.117 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.763186 0.117 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.770886 0.113 1 1
Metabolism of RNA R-HSA-8953854 0.772677 0.112 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.773550 0.112 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 0.773550 0.112 0 0
Folding of actin by CCT/TriC R-HSA-390450 0.773550 0.112 0 0
Josephin domain DUBs R-HSA-5689877 0.773550 0.112 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 0.773550 0.112 0 0
Formation of intermediate mesoderm R-HSA-9761174 0.773550 0.112 0 0
Arachidonate production from DAG R-HSA-426048 0.773550 0.112 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 0.773550 0.112 0 0
Maturation of spike protein R-HSA-9683686 0.773550 0.112 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.773550 0.112 0 0
Pexophagy R-HSA-9664873 0.773550 0.112 0 0
Signaling by ROBO receptors R-HSA-376176 0.775656 0.110 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.777157 0.109 0 0
Gap junction trafficking and regulation R-HSA-157858 0.777888 0.109 0 0
Interleukin-37 signaling R-HSA-9008059 0.778080 0.109 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.778369 0.109 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.778369 0.109 0 0
Formation of definitive endoderm R-HSA-9823730 0.778369 0.109 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.778369 0.109 0 0
Signal transduction by L1 R-HSA-445144 0.778369 0.109 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.779392 0.108 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.783246 0.106 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.783246 0.106 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.783528 0.106 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.785352 0.105 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.785352 0.105 0 0
Interleukin-17 signaling R-HSA-448424 0.785352 0.105 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.790341 0.102 0 0
HCMV Early Events R-HSA-9609690 0.792018 0.101 0 0
Budding and maturation of HIV virion R-HSA-162588 0.793444 0.100 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.793809 0.100 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.795886 0.099 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.796456 0.099 0 0
LGI-ADAM interactions R-HSA-5682910 0.798008 0.098 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.798008 0.098 0 0
vRNP Assembly R-HSA-192905 0.798008 0.098 0 0
Synthesis of PI R-HSA-1483226 0.798008 0.098 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 0.798008 0.098 0 0
Suppression of apoptosis R-HSA-9635465 0.798008 0.098 0 0
MAP kinase activation R-HSA-450294 0.798111 0.098 0 0
PLC beta mediated events R-HSA-112043 0.798111 0.098 0 0
Potential therapeutics for SARS R-HSA-9679191 0.798439 0.098 0 0
Meiotic recombination R-HSA-912446 0.802243 0.096 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.805498 0.094 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.806023 0.094 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.806023 0.094 0 0
Signaling by WNT in cancer R-HSA-4791275 0.807911 0.093 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.808827 0.092 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.812977 0.090 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.813223 0.090 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.813223 0.090 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.813223 0.090 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 0.819826 0.086 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.819826 0.086 0 0
ERKs are inactivated R-HSA-202670 0.819826 0.086 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.819826 0.086 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.819826 0.086 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.819826 0.086 0 0
NF-kB is activated and signals survival R-HSA-209560 0.819826 0.086 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.819826 0.086 0 0
Signaling by Insulin receptor R-HSA-74752 0.821427 0.085 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.821512 0.085 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.821512 0.085 0 0
G-protein beta:gamma signalling R-HSA-397795 0.821512 0.085 0 0
Smooth Muscle Contraction R-HSA-445355 0.824436 0.084 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.828744 0.082 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.828744 0.082 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.828744 0.082 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.828746 0.082 0 0
PPARA activates gene expression R-HSA-1989781 0.831959 0.080 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.834116 0.079 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.834283 0.079 0 0
Translation initiation complex formation R-HSA-72649 0.834753 0.078 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.838313 0.077 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.839289 0.076 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 0.839289 0.076 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 0.839289 0.076 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 0.839289 0.076 0 0
Interleukin-12 signaling R-HSA-9020591 0.842730 0.074 0 0
Formation of the ureteric bud R-HSA-9830674 0.843092 0.074 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 0.843092 0.074 0 0
Syndecan interactions R-HSA-3000170 0.843092 0.074 0 0
Carnitine shuttle R-HSA-200425 0.843092 0.074 0 0
Gap junction trafficking R-HSA-190828 0.843662 0.074 0 0
eNOS activation R-HSA-203615 0.846259 0.072 0 0
Mitophagy R-HSA-5205647 0.846259 0.072 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.846259 0.072 0 0
Reproduction R-HSA-1474165 0.848911 0.071 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.850857 0.070 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.850857 0.070 0 0
Nucleosome assembly R-HSA-774815 0.853876 0.069 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.853876 0.069 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.853876 0.069 0 0
Interleukin-12 family signaling R-HSA-447115 0.855205 0.068 0 0
G-protein mediated events R-HSA-112040 0.855849 0.068 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.856340 0.067 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 0.856650 0.067 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 0.856650 0.067 0 0
FGFR1c ligand binding and activation R-HSA-190373 0.856650 0.067 0 0
Maturation of nucleoprotein R-HSA-9683610 0.856650 0.067 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 0.856650 0.067 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.857475 0.067 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.868559 0.061 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.868559 0.061 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.868559 0.061 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.868559 0.061 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.868929 0.061 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 0.872136 0.059 0 0
cGMP effects R-HSA-418457 0.872136 0.059 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.872136 0.059 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.872136 0.059 0 0
Hydrolysis of LPC R-HSA-1483115 0.872136 0.059 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.872136 0.059 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 0.872136 0.059 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 0.872136 0.059 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 0.872136 0.059 0 0
Physiological factors R-HSA-5578768 0.872136 0.059 0 0
Non-canonical inflammasome activation R-HSA-9686114 0.872136 0.059 0 0
Signal regulatory protein family interactions R-HSA-391160 0.872136 0.059 0 0
Acyl chain remodeling of CL R-HSA-1482798 0.872136 0.059 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 0.872136 0.059 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.872608 0.059 0 0
Stimuli-sensing channels R-HSA-2672351 0.876767 0.057 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.877773 0.057 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.877773 0.057 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.877773 0.057 0 0
NCAM1 interactions R-HSA-419037 0.877773 0.057 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 0.879815 0.056 0 0
GPER1 signaling R-HSA-9634597 0.881172 0.055 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.885951 0.053 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.885951 0.053 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.885951 0.053 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.885951 0.053 0 0
Signaling by Activin R-HSA-1502540 0.885951 0.053 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 0.885951 0.053 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.885951 0.053 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.885951 0.053 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.885951 0.053 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.885951 0.053 0 0
p38MAPK events R-HSA-171007 0.885951 0.053 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.885951 0.053 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 0.885951 0.053 0 0
Other semaphorin interactions R-HSA-416700 0.885951 0.053 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.886666 0.052 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.886925 0.052 0 0
Degradation of CDH1 R-HSA-9766229 0.889230 0.051 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.889230 0.051 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.889230 0.051 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 0.890173 0.051 0 0
Cristae formation R-HSA-8949613 0.890173 0.051 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 0.890173 0.051 0 0
Stabilization of p53 R-HSA-69541 0.895460 0.048 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.895460 0.048 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.896806 0.047 0 0
Azathioprine ADME R-HSA-9748787 0.896806 0.047 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.898273 0.047 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.898273 0.047 0 0
Killing mechanisms R-HSA-9664420 0.898273 0.047 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.898273 0.047 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 0.898273 0.047 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 0.898273 0.047 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.898900 0.046 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.898900 0.046 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.899271 0.046 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.899698 0.046 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.899698 0.046 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.899698 0.046 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.899698 0.046 0 0
Cellular response to starvation R-HSA-9711097 0.900193 0.046 1 0
Unfolded Protein Response (UPR) R-HSA-381119 0.902439 0.045 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.903411 0.044 0 0
Generation of second messenger molecules R-HSA-202433 0.903411 0.044 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.903411 0.044 0 0
Signaling by ERBB4 R-HSA-1236394 0.905295 0.043 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.906897 0.042 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.908447 0.042 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.908447 0.042 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 0.908447 0.042 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.908447 0.042 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.908447 0.042 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.908447 0.042 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.908664 0.042 1 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.909265 0.041 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.909265 0.041 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.909265 0.041 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 0.909265 0.041 0 0
Coenzyme A biosynthesis R-HSA-196783 0.909265 0.041 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.909265 0.041 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 0.909265 0.041 0 0
Galactose catabolism R-HSA-70370 0.909265 0.041 0 0
tRNA modification in the mitochondrion R-HSA-6787450 0.909265 0.041 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.909265 0.041 0 0
Orc1 removal from chromatin R-HSA-68949 0.910601 0.041 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.910601 0.041 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.910811 0.041 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.910811 0.041 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.910827 0.041 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.911006 0.040 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.914660 0.039 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.916441 0.038 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.916477 0.038 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.916862 0.038 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.916862 0.038 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.916862 0.038 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.917693 0.037 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 0.917693 0.037 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.918727 0.037 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.919070 0.037 0 0
Glycogen storage diseases R-HSA-3229121 0.919070 0.037 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 0.919070 0.037 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 0.919070 0.037 0 0
Catecholamine biosynthesis R-HSA-209905 0.919070 0.037 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.919070 0.037 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 0.919070 0.037 0 0
Muscle contraction R-HSA-397014 0.919600 0.036 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.920489 0.036 0 0
Downstream signal transduction R-HSA-186763 0.923842 0.034 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.923842 0.034 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.924086 0.034 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.924652 0.034 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.924914 0.034 0 0
Synthesis of DNA R-HSA-69239 0.925069 0.034 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.925354 0.034 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.925824 0.033 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.925824 0.033 0 0
PCP/CE pathway R-HSA-4086400 0.926380 0.033 0 0
Integrin cell surface interactions R-HSA-216083 0.926380 0.033 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.927816 0.033 0 0
PKA activation R-HSA-163615 0.927816 0.033 0 0
PKA activation in glucagon signalling R-HSA-164378 0.927816 0.033 0 0
FGFR1 ligand binding and activation R-HSA-190242 0.927816 0.033 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.927816 0.033 0 0
Platelet sensitization by LDL R-HSA-432142 0.927816 0.033 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 0.927816 0.033 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.928221 0.032 0 0
G alpha (z) signalling events R-HSA-418597 0.928221 0.032 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.928671 0.032 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.928987 0.032 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.928987 0.032 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.928987 0.032 0 0
Defective pyroptosis R-HSA-9710421 0.930021 0.032 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 0.930021 0.032 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.933358 0.030 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.933358 0.030 0 0
Amine ligand-binding receptors R-HSA-375280 0.935527 0.029 0 0
RMTs methylate histone arginines R-HSA-3214858 0.935527 0.029 0 0
Pyrimidine biosynthesis R-HSA-500753 0.935617 0.029 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.935617 0.029 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 0.935617 0.029 0 0
Diseases of hemostasis R-HSA-9671793 0.935617 0.029 0 0
Methionine salvage pathway R-HSA-1237112 0.935617 0.029 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.935617 0.029 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 0.935617 0.029 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 0.935617 0.029 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.936571 0.028 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.936571 0.028 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.936770 0.028 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.936770 0.028 0 0
Cardiogenesis R-HSA-9733709 0.936770 0.028 0 0
Recycling of bile acids and salts R-HSA-159418 0.936770 0.028 0 0
Ion channel transport R-HSA-983712 0.939325 0.027 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.940412 0.027 0 0
HCMV Infection R-HSA-9609646 0.940466 0.027 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.940588 0.027 0 0
COPII-mediated vesicle transport R-HSA-204005 0.942266 0.026 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.942266 0.026 0 0
Glycogen synthesis R-HSA-3322077 0.942575 0.026 0 0
Acyl chain remodelling of PI R-HSA-1482922 0.942575 0.026 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.942575 0.026 0 0
Synthesis of Ketone Bodies R-HSA-77111 0.942575 0.026 0 0
Protein hydroxylation R-HSA-9629569 0.942575 0.026 0 0
Dual incision in TC-NER R-HSA-6782135 0.942645 0.026 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.943219 0.025 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.943324 0.025 0 0
Protein folding R-HSA-391251 0.944941 0.025 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.944941 0.025 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.945356 0.024 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.945356 0.024 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.945356 0.024 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.945356 0.024 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.945356 0.024 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.945937 0.024 0 0
Signaling by Interleukins R-HSA-449147 0.946052 0.024 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.946184 0.024 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.946184 0.024 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.947015 0.024 0 0
Dual Incision in GG-NER R-HSA-5696400 0.947598 0.023 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.947598 0.023 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.947598 0.023 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.948292 0.023 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.948782 0.023 0 0
ERK/MAPK targets R-HSA-198753 0.948782 0.023 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.948782 0.023 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 0.948782 0.023 0 0
Acyl chain remodelling of PG R-HSA-1482925 0.948782 0.023 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 0.948782 0.023 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 0.948782 0.023 0 0
Basigin interactions R-HSA-210991 0.948782 0.023 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 0.948782 0.023 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.948782 0.023 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.949731 0.022 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.949731 0.022 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.950188 0.022 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.950188 0.022 1 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.950735 0.022 0 0
Glutathione conjugation R-HSA-156590 0.950735 0.022 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.951987 0.021 0 0
DNA Replication R-HSA-69306 0.952703 0.021 0 0
Intraflagellar transport R-HSA-5620924 0.953777 0.021 0 0
Co-stimulation by CD28 R-HSA-389356 0.953777 0.021 1 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.954318 0.020 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 0.954318 0.020 0 0
Nucleotide salvage R-HSA-8956321 0.954374 0.020 0 0
Cellular response to chemical stress R-HSA-9711123 0.956400 0.019 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.956643 0.019 0 0
Glycosphingolipid transport R-HSA-9845576 0.956643 0.019 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.956643 0.019 0 0
Chemokine receptors bind chemokines R-HSA-380108 0.957518 0.019 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.957764 0.019 0 0
Mitochondrial protein import R-HSA-1268020 0.957764 0.019 0 0
Signaling by PDGF R-HSA-186797 0.957764 0.019 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 0.959256 0.018 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.959256 0.018 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 0.959256 0.018 0 0
Signaling by KIT in disease R-HSA-9669938 0.959256 0.018 0 0
LDL clearance R-HSA-8964038 0.959256 0.018 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 0.959256 0.018 0 0
Extracellular matrix organization R-HSA-1474244 0.959567 0.018 0 0
Degradation of DVL R-HSA-4641258 0.960584 0.017 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 0.960584 0.017 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.960920 0.017 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.963343 0.016 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.963343 0.016 0 0
Co-inhibition by PD-1 R-HSA-389948 0.963353 0.016 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.963458 0.016 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.963661 0.016 0 0
Interleukin-20 family signaling R-HSA-8854691 0.963661 0.016 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.963661 0.016 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.963661 0.016 0 0
Organic anion transport by SLCO transporters R-HSA-879518 0.963661 0.016 0 0
Ketone body metabolism R-HSA-74182 0.963661 0.016 0 0
Influenza Infection R-HSA-168255 0.964051 0.016 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.964162 0.016 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.964181 0.016 0 0
Biofilm formation R-HSA-9931953 0.964181 0.016 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.965563 0.015 0 0
Cellular response to hypoxia R-HSA-1234174 0.966586 0.015 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.966596 0.015 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.966596 0.015 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.967070 0.015 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.967104 0.015 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.967104 0.015 0 0
SARS-CoV Infections R-HSA-9679506 0.967245 0.014 0 0
Pentose phosphate pathway R-HSA-71336 0.967461 0.014 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.967461 0.014 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.967461 0.014 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.967589 0.014 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 0.967589 0.014 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.967589 0.014 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.967589 0.014 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.970450 0.013 0 0
Diseases of Immune System R-HSA-5260271 0.970450 0.013 0 0
Glycogen metabolism R-HSA-8982491 0.970450 0.013 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 0.971093 0.013 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 0.971093 0.013 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.971093 0.013 0 0
Cardiac conduction R-HSA-5576891 0.971386 0.013 0 0
Kidney development R-HSA-9830369 0.971478 0.013 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.972172 0.012 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.972172 0.012 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.972319 0.012 0 0
Maturation of spike protein R-HSA-9694548 0.973174 0.012 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.973194 0.012 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.973278 0.012 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.973404 0.012 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.973833 0.012 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.974219 0.011 0 0
MET activates PTK2 signaling R-HSA-8874081 0.974219 0.011 0 0
Urea cycle R-HSA-70635 0.974219 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 0.974219 0.011 0 0
Suppression of phagosomal maturation R-HSA-9637687 0.974219 0.011 0 0
Intra-Golgi traffic R-HSA-6811438 0.975655 0.011 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.975655 0.011 0 0
Translation of Structural Proteins R-HSA-9683701 0.975655 0.011 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.976511 0.010 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.976735 0.010 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.976742 0.010 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 0.977006 0.010 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 0.977006 0.010 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.977006 0.010 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.977006 0.010 0 0
Insulin processing R-HSA-264876 0.977006 0.010 0 0
Signaling by BMP R-HSA-201451 0.977006 0.010 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.977575 0.010 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.977624 0.010 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.977912 0.010 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.977912 0.010 0 0
RSV-host interactions R-HSA-9833110 0.977968 0.010 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.977989 0.010 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.978338 0.010 0 0
Synthesis of PA R-HSA-1483166 0.978693 0.009 0 0
HCMV Late Events R-HSA-9610379 0.978976 0.009 0 0
Hedgehog 'on' state R-HSA-5632684 0.979319 0.009 0 0
ECM proteoglycans R-HSA-3000178 0.979319 0.009 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.979319 0.009 0 0
Metabolism of cofactors R-HSA-8978934 0.979319 0.009 0 0
Pyroptosis R-HSA-5620971 0.979493 0.009 0 0
Insulin receptor recycling R-HSA-77387 0.979493 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.979493 0.009 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.979967 0.009 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.980637 0.008 0 0
Platelet homeostasis R-HSA-418346 0.980786 0.008 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.980934 0.008 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.981241 0.008 0 0
Interferon gamma signaling R-HSA-877300 0.981253 0.008 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.981711 0.008 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.981717 0.008 0 0
tRNA processing R-HSA-72306 0.981966 0.008 0 0
Regulation of beta-cell development R-HSA-186712 0.982138 0.008 0 0
Potassium Channels R-HSA-1296071 0.982553 0.008 0 0
Gastrulation R-HSA-9758941 0.982775 0.008 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.983266 0.007 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.983266 0.007 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.983534 0.007 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.983534 0.007 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.983534 0.007 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.983689 0.007 0 0
Mucopolysaccharidoses R-HSA-2206281 0.983689 0.007 0 0
Adaptive Immune System R-HSA-1280218 0.984074 0.007 1 0
Pyruvate metabolism R-HSA-70268 0.984734 0.007 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.984923 0.007 0 0
Regulation of insulin secretion R-HSA-422356 0.984923 0.007 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.985045 0.007 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.985078 0.007 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.985078 0.007 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.985078 0.007 0 0
Protein ubiquitination R-HSA-8852135 0.985093 0.007 0 0
TCR signaling R-HSA-202403 0.985446 0.006 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.985446 0.006 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.985453 0.006 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.985453 0.006 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.985453 0.006 0 0
HS-GAG degradation R-HSA-2024096 0.987026 0.006 0 0
Translation of Structural Proteins R-HSA-9694635 0.987370 0.006 0 0
Interleukin-1 signaling R-HSA-9020702 0.987919 0.005 0 0
SLC transporter disorders R-HSA-5619102 0.988280 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 0.988380 0.005 0 0
Defective B3GALTL causes PpS R-HSA-5083635 0.988429 0.005 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.988429 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 0.988429 0.005 0 0
Host Interactions of HIV factors R-HSA-162909 0.988716 0.005 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.989005 0.005 1 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.989681 0.005 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.989681 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 0.989681 0.005 0 0
Heme degradation R-HSA-189483 0.989681 0.005 0 0
Glutamate and glutamine metabolism R-HSA-8964539 0.989681 0.005 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.990175 0.004 1 1
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.990462 0.004 0 0
Gap junction assembly R-HSA-190861 0.990797 0.004 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.990797 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.990797 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 0.990797 0.004 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 0.990797 0.004 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.990914 0.004 0 0
The phototransduction cascade R-HSA-2514856 0.990914 0.004 0 0
Amyloid fiber formation R-HSA-977225 0.990969 0.004 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.991252 0.004 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 0.991291 0.004 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.991339 0.004 0 0
Platelet degranulation R-HSA-114608 0.991437 0.004 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.991793 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.991793 0.004 0 0
PERK regulates gene expression R-HSA-381042 0.991793 0.004 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.992309 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.992378 0.003 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.992492 0.003 0 0
Nucleotide biosynthesis R-HSA-8956320 0.992561 0.003 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.992681 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.992681 0.003 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.992744 0.003 0 0
Parasite infection R-HSA-9664407 0.992854 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 0.992854 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.992854 0.003 0 0
Eukaryotic Translation Termination R-HSA-72764 0.993072 0.003 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.993216 0.003 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.993271 0.003 0 0
Neddylation R-HSA-8951664 0.993446 0.003 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 0.993473 0.003 0 0
Ubiquinol biosynthesis R-HSA-2142789 0.993473 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 0.993473 0.003 0 0
Protein localization R-HSA-9609507 0.993649 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.993961 0.003 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.994103 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 0.994179 0.003 0 0
Elastic fibre formation R-HSA-1566948 0.994179 0.003 0 0
Purine salvage R-HSA-74217 0.994179 0.003 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.994493 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 0.994809 0.002 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.994847 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.995156 0.002 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 0.995371 0.002 0 0
Peptide chain elongation R-HSA-156902 0.995449 0.002 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.995505 0.002 0 0
Developmental Biology R-HSA-1266738 0.995805 0.002 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.995872 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 0.995872 0.002 0 0
Peroxisomal protein import R-HSA-9033241 0.995938 0.002 0 0
Integration of energy metabolism R-HSA-163685 0.996083 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 0.996176 0.002 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.996319 0.002 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.996319 0.002 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.996319 0.002 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.996319 0.002 0 0
tRNA Aminoacylation R-HSA-379724 0.996330 0.002 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.996496 0.002 0 0
Aquaporin-mediated transport R-HSA-445717 0.996685 0.001 0 0
Endogenous sterols R-HSA-211976 0.996685 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.996717 0.001 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.997006 0.001 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.997060 0.001 0 0
Pyrimidine catabolism R-HSA-73621 0.997072 0.001 0 0
Interleukin-1 family signaling R-HSA-446652 0.997106 0.001 0 0
PKR-mediated signaling R-HSA-9833482 0.997389 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.997389 0.001 0 0
Surfactant metabolism R-HSA-5683826 0.997389 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 0.997389 0.001 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.997624 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.997672 0.001 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 0.997672 0.001 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.997672 0.001 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.997672 0.001 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.997936 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 0.998112 0.001 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.998144 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 0.998149 0.001 0 0
Neuronal System R-HSA-112316 0.998337 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 0.998413 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 0.998421 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.998528 0.001 0 0
Phospholipid metabolism R-HSA-1483257 0.998675 0.001 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.998699 0.001 0 0
Selenocysteine synthesis R-HSA-2408557 0.998795 0.001 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.998804 0.001 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.998829 0.001 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.998956 0.000 0 0
Toll-like Receptor Cascades R-HSA-168898 0.998963 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 0.998986 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 0.998992 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.998994 0.000 0 0
Viral mRNA Translation R-HSA-192823 0.998994 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 0.999034 0.000 0 0
Downstream TCR signaling R-HSA-202424 0.999085 0.000 0 0
Interferon Signaling R-HSA-913531 0.999190 0.000 0 0
Paracetamol ADME R-HSA-9753281 0.999260 0.000 0 0
Hemostasis R-HSA-109582 0.999307 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 0.999340 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.999418 0.000 0 0
Neutrophil degranulation R-HSA-6798695 0.999431 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 0.999436 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 0.999469 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 0.999492 0.000 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.999495 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 0.999532 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 0.999583 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.999583 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 0.999614 0.000 0 0
Signaling by Hedgehog R-HSA-5358351 0.999614 0.000 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.999628 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 0.999693 0.000 0 0
Hedgehog 'off' state R-HSA-5610787 0.999715 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 0.999736 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 0.999736 0.000 0 0
G alpha (s) signalling events R-HSA-418555 0.999771 0.000 0 0
Nicotinate metabolism R-HSA-196807 0.999813 0.000 0 0
Metabolism of porphyrins R-HSA-189445 0.999882 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.999893 0.000 0 0
Purine catabolism R-HSA-74259 0.999895 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.999916 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 0.999925 0.000 0 0
Iron uptake and transport R-HSA-917937 0.999925 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 0.999937 0.000 0 0
Leishmania infection R-HSA-9658195 0.999937 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.999937 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.999946 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 0.999947 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.999947 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.999953 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.999958 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999961 0.000 0 0
Metabolism of nucleotides R-HSA-15869 0.999966 0.000 0 0
G alpha (q) signalling events R-HSA-416476 0.999968 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999969 0.000 0 0
Viral Infection Pathways R-HSA-9824446 0.999977 0.000 0 0
Mitochondrial translation R-HSA-5368287 0.999979 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999981 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 0.999981 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.999981 0.000 0 0
rRNA processing R-HSA-72312 0.999985 0.000 0 0
Antimicrobial peptides R-HSA-6803157 0.999989 0.000 0 0
Nucleotide catabolism R-HSA-8956319 0.999990 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 0.999992 0.000 0 0
GPCR downstream signalling R-HSA-388396 0.999992 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 0.999994 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.999994 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 0.999994 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.999995 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.999997 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 0.999997 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 0.999998 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.999998 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 0.999999 0.000 0 0
Sphingolipid metabolism R-HSA-428157 0.999999 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 0.999999 0.000 0 0
Keratinization R-HSA-6805567 0.999999 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 1.000000 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000 0.000 0 0
Translation R-HSA-72766 1.000000 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000 0.000 0 0
Immune System R-HSA-168256 1.000000 0.000 1 0
G alpha (i) signalling events R-HSA-418594 1.000000 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 1.000000 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 1.000000 0.000 0 0
Drug ADME R-HSA-9748784 1.000000 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000 0.000 0 0
Infectious disease R-HSA-5663205 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Innate Immune System R-HSA-168249 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000 0.000 0 0
Disease R-HSA-1643685 1.000000 0.000 1 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000 -0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 9.503421e-09 8.022 1 0
Signal Transduction R-HSA-162582 3.032776e-07 6.518 1 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.123646e-07 6.213 0 0
Chromatin organization R-HSA-4839726 1.528728e-06 5.816 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.711174e-06 5.767 0 0
HSF1-dependent transactivation R-HSA-3371571 2.274770e-06 5.643 1 1
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.314713e-06 5.275 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.538420e-06 5.123 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.538420e-06 5.123 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.252684e-06 5.083 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.516848e-06 5.022 0 0
Attenuation phase R-HSA-3371568 1.609124e-05 4.793 0 0
Signaling by Hippo R-HSA-2028269 1.678376e-05 4.775 0 0
Apoptotic execution phase R-HSA-75153 1.565785e-05 4.805 0 0
Chromatin modifying enzymes R-HSA-3247509 3.180056e-05 4.498 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.326719e-05 4.478 1 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.757694e-05 4.425 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.867857e-05 4.413 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.715361e-05 4.430 1 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.477929e-05 4.349 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.956524e-05 4.225 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.432249e-05 4.129 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.384007e-04 3.859 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.954790e-04 3.709 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.077811e-04 3.682 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.701131e-04 3.568 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.938643e-04 3.532 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.078119e-04 3.390 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.430765e-04 3.192 0 0
Gene expression (Transcription) R-HSA-74160 6.815353e-04 3.167 1 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.782010e-04 3.109 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.782010e-04 3.109 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.579237e-04 3.120 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.782010e-04 3.109 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.053179e-04 3.094 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 9.483464e-04 3.023 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.987571e-04 3.046 1 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.483464e-04 3.023 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.117856e-03 2.952 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.111553e-03 2.954 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.176641e-03 2.929 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.176641e-03 2.929 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.219384e-03 2.914 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.265324e-03 2.898 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.232540e-03 2.909 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.249024e-03 2.903 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.327813e-03 2.877 0 0
Signaling by NOTCH1 R-HSA-1980143 1.340822e-03 2.873 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.417105e-03 2.849 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.565415e-03 2.805 0 0
Nuclear import of Rev protein R-HSA-180746 1.568423e-03 2.805 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.598952e-03 2.796 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.641864e-03 2.785 0 0
MTOR signalling R-HSA-165159 1.743574e-03 2.759 1 1
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.842820e-03 2.735 0 0
RUNX2 regulates bone development R-HSA-8941326 2.154297e-03 2.667 0 0
Signaling by VEGF R-HSA-194138 2.238124e-03 2.650 1 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.313980e-03 2.636 0 0
Notch-HLH transcription pathway R-HSA-350054 2.498264e-03 2.602 0 0
mTORC1-mediated signalling R-HSA-166208 2.498264e-03 2.602 1 1
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.506303e-03 2.601 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.506303e-03 2.601 0 0
Cell Cycle, Mitotic R-HSA-69278 2.527797e-03 2.597 0 0
Cellular Senescence R-HSA-2559583 2.965291e-03 2.528 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.025486e-03 2.519 1 1
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.346415e-03 2.475 0 0
Signaling by ALK R-HSA-201556 3.346415e-03 2.475 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.592827e-03 2.445 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.842114e-03 2.415 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.066621e-03 2.391 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.066621e-03 2.391 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.310998e-03 2.365 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.316555e-03 2.365 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.393506e-03 2.357 0 0
RNA Polymerase II Transcription R-HSA-73857 4.535199e-03 2.343 1 0
Death Receptor Signaling R-HSA-73887 4.555235e-03 2.341 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.612624e-03 2.336 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.026824e-03 2.299 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.208042e-03 2.283 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.208042e-03 2.283 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.208042e-03 2.283 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.208042e-03 2.283 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.208042e-03 2.283 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.781174e-03 2.238 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.781174e-03 2.238 0 0
HIV Life Cycle R-HSA-162587 5.497517e-03 2.260 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.513371e-03 2.259 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.872856e-03 2.231 0 0
Formation of annular gap junctions R-HSA-196025 5.872856e-03 2.231 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.872856e-03 2.231 0 0
mRNA 3'-end processing R-HSA-72187 6.170897e-03 2.210 0 0
Signaling by NTRKs R-HSA-166520 6.355851e-03 2.197 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.902137e-03 2.229 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.383688e-03 2.195 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.428601e-03 2.192 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.680364e-03 2.175 1 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 7.106875e-03 2.148 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.033310e-03 2.153 0 0
HSF1 activation R-HSA-3371511 7.347993e-03 2.134 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.441393e-03 2.128 0 0
Cellular responses to stress R-HSA-2262752 7.419900e-03 2.130 1 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.068596e-03 2.151 0 0
Gap junction degradation R-HSA-190873 7.913874e-03 2.102 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.913874e-03 2.102 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.131861e-03 2.090 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.586055e-03 2.066 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.903056e-03 2.050 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.903056e-03 2.050 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.612491e-03 2.065 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.106019e-03 2.041 0 0
MAPK family signaling cascades R-HSA-5683057 9.205558e-03 2.036 0 0
NRAGE signals death through JNK R-HSA-193648 9.418649e-03 2.026 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.424144e-03 2.026 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.653405e-03 2.015 0 0
ESR-mediated signaling R-HSA-8939211 9.976178e-03 2.001 0 0
Prolonged ERK activation events R-HSA-169893 1.002959e-02 1.999 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.037232e-02 1.984 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.076827e-02 1.968 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.094248e-02 1.961 0 0
Cell Cycle R-HSA-1640170 1.151779e-02 1.939 0 0
Cell-Cell communication R-HSA-1500931 1.205009e-02 1.919 0 0
Cell junction organization R-HSA-446728 1.188853e-02 1.925 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.349646e-02 1.870 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.383383e-02 1.859 1 1
Nuclear RNA decay R-HSA-9930044 1.405308e-02 1.852 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.533979e-02 1.814 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.573516e-02 1.803 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.589987e-02 1.799 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.590488e-02 1.798 0 0
TGFBR3 expression R-HSA-9839394 1.598619e-02 1.796 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.626386e-02 1.789 0 0
Activation of RAC1 R-HSA-428540 1.665344e-02 1.778 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.835357e-02 1.736 0 0
tRNA processing in the nucleus R-HSA-6784531 1.654955e-02 1.781 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.747630e-02 1.758 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.889186e-02 1.724 0 0
Signaling by NOTCH R-HSA-157118 1.957206e-02 1.708 0 0
Signalling to ERKs R-HSA-187687 2.011543e-02 1.696 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.017193e-02 1.695 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.017193e-02 1.695 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.052193e-02 1.688 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.052193e-02 1.688 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.052193e-02 1.688 0 0
Repression of WNT target genes R-HSA-4641265 2.052193e-02 1.688 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.084711e-02 1.681 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.084711e-02 1.681 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.370001e-02 1.625 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.302388e-02 1.638 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.313536e-02 1.636 0 0
Signaling by EGFR R-HSA-177929 2.428955e-02 1.615 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.275160e-02 1.643 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.489938e-02 1.604 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.489938e-02 1.604 0 0
Signaling by TGFBR3 R-HSA-9839373 2.503447e-02 1.601 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.539457e-02 1.595 0 0
Apoptosis R-HSA-109581 2.615510e-02 1.582 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.686485e-02 1.571 0 0
Generic Transcription Pathway R-HSA-212436 2.722756e-02 1.565 1 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.729977e-02 1.564 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.729977e-02 1.564 0 0
SOS-mediated signalling R-HSA-112412 2.729977e-02 1.564 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.979839e-02 1.526 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.740500e-02 1.562 0 0
Regulation of TP53 Expression R-HSA-6804754 2.772871e-02 1.557 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.729977e-02 1.564 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.065640e-02 1.513 0 0
HATs acetylate histones R-HSA-3214847 2.786907e-02 1.555 0 0
Mitotic Prophase R-HSA-68875 2.901837e-02 1.537 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.729977e-02 1.564 0 0
NGF-stimulated transcription R-HSA-9031628 3.007058e-02 1.522 0 0
Metabolism of non-coding RNA R-HSA-194441 3.115563e-02 1.506 0 0
snRNP Assembly R-HSA-191859 3.115563e-02 1.506 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.145873e-02 1.502 0 0
M Phase R-HSA-68886 3.176065e-02 1.498 0 0
HIV Infection R-HSA-162906 3.204882e-02 1.494 0 0
Inositol phosphate metabolism R-HSA-1483249 3.207493e-02 1.494 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.371688e-02 1.472 0 0
Mitotic Anaphase R-HSA-68882 3.426959e-02 1.465 0 0
EPH-Ephrin signaling R-HSA-2682334 3.463380e-02 1.460 0 0
Type I hemidesmosome assembly R-HSA-446107 3.469370e-02 1.460 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.469370e-02 1.460 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.522761e-02 1.453 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.564542e-02 1.448 0 0
Mitotic Prometaphase R-HSA-68877 3.610046e-02 1.442 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.628554e-02 1.440 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.301335e-02 1.366 0 0
ARMS-mediated activation R-HSA-170984 4.301335e-02 1.366 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.301335e-02 1.366 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 4.119186e-02 1.385 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.761974e-02 1.425 0 0
G0 and Early G1 R-HSA-1538133 3.765031e-02 1.424 0 0
DNA strand elongation R-HSA-69190 3.765031e-02 1.424 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.163341e-02 1.381 0 0
S Phase R-HSA-69242 4.287760e-02 1.368 0 0
Signaling by WNT R-HSA-195721 4.017969e-02 1.396 0 0
Unwinding of DNA R-HSA-176974 4.301335e-02 1.366 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.020377e-02 1.396 0 0
Nervous system development R-HSA-9675108 4.162180e-02 1.381 0 0
Cellular responses to stimuli R-HSA-8953897 4.081890e-02 1.389 1 0
Heme signaling R-HSA-9707616 3.926741e-02 1.406 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.079909e-02 1.389 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.480522e-02 1.349 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.480522e-02 1.349 0 0
Striated Muscle Contraction R-HSA-390522 4.618267e-02 1.336 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.769232e-02 1.322 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.769232e-02 1.322 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.769232e-02 1.322 0 0
Separation of Sister Chromatids R-HSA-2467813 4.997282e-02 1.301 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.202592e-02 1.284 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.223369e-02 1.282 0 0
Signal attenuation R-HSA-74749 5.223369e-02 1.282 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 6.207888e-02 1.207 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.742135e-02 1.241 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.742135e-02 1.241 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.742135e-02 1.241 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.742135e-02 1.241 0 0
Ephrin signaling R-HSA-3928664 6.228973e-02 1.206 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.716877e-02 1.243 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.716877e-02 1.243 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.341867e-02 1.198 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.341867e-02 1.198 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.198272e-02 1.208 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.198272e-02 1.208 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.198272e-02 1.208 0 0
mRNA Splicing R-HSA-72172 5.756445e-02 1.240 0 0
Transcription of the HIV genome R-HSA-167172 5.953051e-02 1.225 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.285466e-02 1.277 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.228973e-02 1.206 0 0
Signaling by RAS mutants R-HSA-6802949 6.198272e-02 1.208 0 0
Polo-like kinase mediated events R-HSA-156711 6.228973e-02 1.206 0 0
Adipogenesis R-HSA-9843745 5.589507e-02 1.253 0 0
Signaling by MET R-HSA-6806834 6.082717e-02 1.216 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.719972e-02 1.243 0 0
Adherens junctions interactions R-HSA-418990 5.963838e-02 1.224 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.123231e-02 1.213 0 0
G alpha (12/13) signalling events R-HSA-416482 5.388959e-02 1.268 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.435940e-02 1.191 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.659056e-02 1.177 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.659056e-02 1.177 0 0
Collagen chain trimerization R-HSA-8948216 6.659056e-02 1.177 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.688556e-02 1.175 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.754149e-02 1.170 0 0
IRS activation R-HSA-74713 7.500692e-02 1.125 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 7.500692e-02 1.125 0 0
G2 Phase R-HSA-68911 7.500692e-02 1.125 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.323893e-02 1.135 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.494073e-02 1.071 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.037286e-02 1.153 0 0
HIV elongation arrest and recovery R-HSA-167287 7.003719e-02 1.155 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.003719e-02 1.155 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.484837e-02 1.071 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.619750e-02 1.118 0 0
Nucleotide Excision Repair R-HSA-5696398 7.839149e-02 1.106 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.436580e-02 1.074 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.637357e-02 1.117 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.436580e-02 1.074 1 1
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.896505e-02 1.103 0 0
MET activates RAS signaling R-HSA-8851805 8.494073e-02 1.071 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 7.500692e-02 1.125 0 0
Signaling by LTK R-HSA-9842663 8.494073e-02 1.071 0 0
MAP kinase activation R-HSA-450294 7.986804e-02 1.098 0 0
Metabolism of RNA R-HSA-8953854 7.286560e-02 1.137 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.848295e-02 1.105 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.494073e-02 1.071 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.702109e-02 1.113 0 0
Developmental Biology R-HSA-1266738 7.370780e-02 1.132 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.494073e-02 1.071 0 0
Regulation of TP53 Activity R-HSA-5633007 7.117328e-02 1.148 1 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.848295e-02 1.105 1 0
Axon guidance R-HSA-422475 8.542142e-02 1.068 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.951782e-02 1.048 0 0
Semaphorin interactions R-HSA-373755 9.032100e-02 1.044 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.147225e-02 1.039 0 0
EGFR downregulation R-HSA-182971 9.206543e-02 1.036 0 0
Programmed Cell Death R-HSA-5357801 9.343166e-02 1.030 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 9.404228e-02 1.027 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 9.404228e-02 1.027 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 9.404228e-02 1.027 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 9.404228e-02 1.027 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 9.404228e-02 1.027 0 0
UCH proteinases R-HSA-5689603 9.545637e-02 1.020 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.638503e-02 1.016 1 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 9.737952e-02 1.012 0 0
Frs2-mediated activation R-HSA-170968 9.737952e-02 1.012 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.840454e-02 1.007 0 0
Signaling by RAF1 mutants R-HSA-9656223 9.840454e-02 1.007 0 0
HIV Transcription Initiation R-HSA-167161 9.840454e-02 1.007 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.840454e-02 1.007 0 0
MAP2K and MAPK activation R-HSA-5674135 9.840454e-02 1.007 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.840454e-02 1.007 0 0
Smooth Muscle Contraction R-HSA-445355 1.010480e-01 0.995 0 0
FOXO-mediated transcription R-HSA-9614085 1.013470e-01 0.994 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.203075e-01 0.920 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.203075e-01 0.920 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.203075e-01 0.920 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.203075e-01 0.920 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.203075e-01 0.920 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.203075e-01 0.920 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.142800e-01 0.942 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.142800e-01 0.942 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.354979e-01 0.868 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.354979e-01 0.868 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.354979e-01 0.868 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.105047e-01 0.957 0 0
Erythropoietin activates RAS R-HSA-9027284 1.242639e-01 0.906 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.242639e-01 0.906 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.242639e-01 0.906 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.386035e-01 0.858 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.290170e-01 0.889 0 0
RAF activation R-HSA-5673000 1.262552e-01 0.899 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.130350e-01 0.947 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 1.286989e-01 0.890 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.090267e-01 0.962 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.386035e-01 0.858 0 0
Killing mechanisms R-HSA-9664420 1.386035e-01 0.858 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 1.386035e-01 0.858 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.116384e-01 0.952 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.085000e-01 0.965 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.290170e-01 0.889 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.105047e-01 0.957 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.142843e-01 0.942 0 0
Signaling by NOTCH3 R-HSA-9012852 1.142102e-01 0.942 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.172175e-01 0.931 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.185232e-01 0.926 1 1
Formation of editosomes by ADAR proteins R-HSA-77042 1.203075e-01 0.920 0 0
Oncogene Induced Senescence R-HSA-2559585 1.356019e-01 0.868 0 0
p75NTR signals via NF-kB R-HSA-193639 1.242639e-01 0.906 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.290170e-01 0.889 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.197163e-01 0.922 0 0
Interleukin-17 signaling R-HSA-448424 1.327408e-01 0.877 0 0
Neurodegenerative Diseases R-HSA-8863678 1.290170e-01 0.889 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.290170e-01 0.889 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.172895e-01 0.931 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.211124e-01 0.917 0 0
Host Interactions of HIV factors R-HSA-162909 1.122395e-01 0.950 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.085000e-01 0.965 0 0
Cell-cell junction organization R-HSA-421270 1.101564e-01 0.958 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.354979e-01 0.868 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.386035e-01 0.858 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.085000e-01 0.965 0 0
Regulation of CDH1 Function R-HSA-9764561 1.282237e-01 0.892 0 0
Cell Cycle Checkpoints R-HSA-69620 1.328827e-01 0.877 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.076500e-01 0.968 0 0
TNF signaling R-HSA-75893 1.211124e-01 0.917 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.231418e-01 0.910 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.369029e-01 0.864 0 0
IRE1alpha activates chaperones R-HSA-381070 1.196211e-01 0.922 0 0
HDMs demethylate histones R-HSA-3214842 1.403114e-01 0.853 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.403114e-01 0.853 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.430561e-01 0.844 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 1.430561e-01 0.844 0 0
Macroautophagy R-HSA-1632852 1.438073e-01 0.842 1 1
RAF/MAP kinase cascade R-HSA-5673001 1.438316e-01 0.842 0 0
RET signaling R-HSA-8853659 1.452458e-01 0.838 0 0
Recycling pathway of L1 R-HSA-437239 1.453454e-01 0.838 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.464654e-01 0.834 0 0
Gene Silencing by RNA R-HSA-211000 1.480499e-01 0.830 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.480499e-01 0.830 0 0
Signaling by ALK in cancer R-HSA-9700206 1.480499e-01 0.830 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.749244e-01 0.757 0 0
IKBKB deficiency causes SCID R-HSA-5602636 1.749244e-01 0.757 0 0
Defective VWF binding to collagen type I R-HSA-9845622 1.749244e-01 0.757 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 1.749244e-01 0.757 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 1.749244e-01 0.757 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.261534e-01 0.646 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.261534e-01 0.646 0 0
Regulation of cortical dendrite branching R-HSA-8985801 2.261534e-01 0.646 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.261534e-01 0.646 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.261534e-01 0.646 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 2.261534e-01 0.646 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.261534e-01 0.646 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.261534e-01 0.646 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 2.261534e-01 0.646 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.261534e-01 0.646 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.261534e-01 0.646 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.261534e-01 0.646 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.261534e-01 0.646 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.261534e-01 0.646 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.261534e-01 0.646 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 2.261534e-01 0.646 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.261534e-01 0.646 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 2.742045e-01 0.562 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.742045e-01 0.562 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.742045e-01 0.562 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.574964e-01 0.803 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.574964e-01 0.803 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.800972e-01 0.744 0 0
Lipophagy R-HSA-9613354 1.800972e-01 0.744 0 0
WNT mediated activation of DVL R-HSA-201688 1.800972e-01 0.744 0 0
HCN channels R-HSA-1296061 3.192746e-01 0.496 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 3.192746e-01 0.496 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.192746e-01 0.496 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 3.192746e-01 0.496 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.031410e-01 0.692 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 2.031410e-01 0.692 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 2.264857e-01 0.645 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.264857e-01 0.645 0 0
Signaling by APC mutants R-HSA-4839744 2.264857e-01 0.645 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.264857e-01 0.645 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.264857e-01 0.645 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.264857e-01 0.645 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 3.615485e-01 0.442 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 3.615485e-01 0.442 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.615485e-01 0.442 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.615485e-01 0.442 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.688075e-01 0.773 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.500054e-01 0.602 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.500054e-01 0.602 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.735885e-01 0.563 0 0
Polymerase switching R-HSA-69091 2.735885e-01 0.563 0 0
Leading Strand Synthesis R-HSA-69109 2.735885e-01 0.563 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.735885e-01 0.563 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.735885e-01 0.563 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.735885e-01 0.563 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.735885e-01 0.563 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.735885e-01 0.563 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.735885e-01 0.563 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 4.011996e-01 0.397 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 4.011996e-01 0.397 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 4.011996e-01 0.397 0 0
Phosphorylation of Emi1 R-HSA-176417 4.011996e-01 0.397 0 0
Signaling by MAPK mutants R-HSA-9652817 4.011996e-01 0.397 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.011996e-01 0.397 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.763593e-01 0.754 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.763593e-01 0.754 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.971366e-01 0.527 0 0
Formation of axial mesoderm R-HSA-9796292 2.971366e-01 0.527 0 0
Lagging Strand Synthesis R-HSA-69186 2.338305e-01 0.631 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.019496e-01 0.695 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.019496e-01 0.695 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.507519e-01 0.601 0 0
Removal of the Flap Intermediate R-HSA-69166 3.205632e-01 0.494 0 0
Retrograde neurotrophin signalling R-HSA-177504 3.205632e-01 0.494 0 0
Signaling by LTK in cancer R-HSA-9842640 4.383903e-01 0.358 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 4.383903e-01 0.358 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.383903e-01 0.358 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.865318e-01 0.729 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.437928e-01 0.464 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.437928e-01 0.464 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.850650e-01 0.545 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.850650e-01 0.545 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.908511e-01 0.719 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.199456e-01 0.658 0 0
Deadenylation of mRNA R-HSA-429947 3.023710e-01 0.519 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.667595e-01 0.436 0 0
Phosphorylation of the APC/C R-HSA-176412 3.667595e-01 0.436 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.005482e-01 0.698 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.894064e-01 0.410 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.669898e-01 0.574 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.116848e-01 0.385 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.716935e-01 0.430 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.335532e-01 0.363 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.335532e-01 0.363 0 0
Signaling by Erythropoietin R-HSA-9006335 3.888791e-01 0.410 0 0
Late endosomal microautophagy R-HSA-9615710 3.888791e-01 0.410 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.054984e-01 0.515 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.054984e-01 0.515 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.059468e-01 0.392 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.549766e-01 0.342 0 0
Meiotic synapsis R-HSA-1221632 3.534222e-01 0.452 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.388498e-01 0.470 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.613006e-01 0.442 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.910424e-01 0.408 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.160483e-01 0.381 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.176121e-01 0.379 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.532097e-01 0.344 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.400178e-01 0.357 0 0
Centrosome maturation R-HSA-380287 4.400178e-01 0.357 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.285291e-01 0.368 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.465570e-01 0.350 0 0
HIV Transcription Elongation R-HSA-167169 1.865318e-01 0.729 0 0
HCMV Early Events R-HSA-9609690 2.239937e-01 0.650 0 0
mRNA Capping R-HSA-72086 3.888791e-01 0.410 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.171266e-01 0.663 0 0
Circadian clock R-HSA-9909396 1.613229e-01 0.792 0 0
Activation of the pre-replicative complex R-HSA-68962 2.019496e-01 0.695 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.865318e-01 0.729 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.372880e-01 0.625 0 0
Aggrephagy R-HSA-9646399 1.865318e-01 0.729 0 0
Signaling by ERBB2 R-HSA-1227986 4.408836e-01 0.356 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.124262e-01 0.505 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.800972e-01 0.744 0 0
PCP/CE pathway R-HSA-4086400 1.914447e-01 0.718 0 0
Cyclin D associated events in G1 R-HSA-69231 2.431631e-01 0.614 0 0
G1 Phase R-HSA-69236 2.431631e-01 0.614 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.358246e-01 0.627 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.800972e-01 0.744 0 0
PI3K/AKT activation R-HSA-198203 2.031410e-01 0.692 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.534694e-01 0.814 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.264857e-01 0.645 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.758312e-01 0.755 0 0
HDACs deacetylate histones R-HSA-3214815 3.785047e-01 0.422 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.171217e-01 0.499 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.192746e-01 0.496 0 0
Regulation of gap junction activity R-HSA-191650 3.192746e-01 0.496 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 3.615485e-01 0.442 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.735885e-01 0.563 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.437928e-01 0.464 0 0
Trafficking of AMPA receptors R-HSA-399719 4.228703e-01 0.374 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.154654e-01 0.667 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.154654e-01 0.667 0 0
Synthesis of DNA R-HSA-69239 2.376377e-01 0.624 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.284929e-01 0.368 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.735885e-01 0.563 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.640067e-01 0.785 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.951029e-01 0.403 0 0
G1/S Transition R-HSA-69206 4.089176e-01 0.388 0 0
Calcineurin activates NFAT R-HSA-2025928 1.800972e-01 0.744 0 0
Formation of the posterior neural plate R-HSA-9832991 2.264857e-01 0.645 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 3.615485e-01 0.442 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 3.615485e-01 0.442 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.615485e-01 0.442 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.500054e-01 0.602 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.335532e-01 0.363 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.985240e-01 0.400 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.845646e-01 0.734 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.971366e-01 0.527 0 0
PTEN Regulation R-HSA-6807070 2.072942e-01 0.683 1 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.228703e-01 0.374 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.519826e-01 0.818 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.011996e-01 0.397 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.116848e-01 0.385 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.116848e-01 0.385 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.082678e-01 0.681 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.971233e-01 0.705 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.410499e-01 0.356 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.385713e-01 0.622 0 0
Ion homeostasis R-HSA-5578775 3.910424e-01 0.408 0 0
Collagen formation R-HSA-1474290 3.513592e-01 0.454 0 0
MET promotes cell motility R-HSA-8875878 1.653739e-01 0.782 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.850650e-01 0.545 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.888791e-01 0.410 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.532097e-01 0.344 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.385713e-01 0.622 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.602793e-01 0.585 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.500054e-01 0.602 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.698593e-01 0.432 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.602793e-01 0.585 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.894103e-01 0.723 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 3.613006e-01 0.442 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.176121e-01 0.379 0 0
Signaling by ROBO receptors R-HSA-376176 4.538176e-01 0.343 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.575168e-01 0.447 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 1.749244e-01 0.757 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.749244e-01 0.757 0 0
mRNA Editing: A to I Conversion R-HSA-75064 2.261534e-01 0.646 0 0
C6 deamination of adenosine R-HSA-75102 2.261534e-01 0.646 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.261534e-01 0.646 0 0
MET interacts with TNS proteins R-HSA-8875513 2.742045e-01 0.562 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.742045e-01 0.562 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.192746e-01 0.496 0 0
Disorders of Developmental Biology R-HSA-9675151 1.534694e-01 0.814 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 2.264857e-01 0.645 0 0
Reelin signalling pathway R-HSA-8866376 3.615485e-01 0.442 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.500054e-01 0.602 0 0
NF-kB is activated and signals survival R-HSA-209560 2.500054e-01 0.602 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.500054e-01 0.602 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.500054e-01 0.602 0 0
Signaling by AXIN mutants R-HSA-4839735 2.500054e-01 0.602 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.971366e-01 0.527 0 0
Platelet calcium homeostasis R-HSA-418360 1.890153e-01 0.724 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.437928e-01 0.464 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.023710e-01 0.519 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.894064e-01 0.410 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.544182e-01 0.450 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.562857e-01 0.591 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.335532e-01 0.363 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.659475e-01 0.575 0 0
Signaling by NOTCH4 R-HSA-9013694 2.757073e-01 0.560 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.549766e-01 0.342 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.549766e-01 0.342 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.689677e-01 0.772 0 0
Autophagy R-HSA-9612973 1.560085e-01 0.807 1 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.452095e-01 0.610 0 0
Selective autophagy R-HSA-9663891 1.753061e-01 0.756 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.089835e-01 0.388 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.205632e-01 0.494 0 0
Membrane Trafficking R-HSA-199991 2.803689e-01 0.552 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.974610e-01 0.705 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.436201e-01 0.464 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.842117e-01 0.415 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.717288e-01 0.566 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.205632e-01 0.494 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 3.716935e-01 0.430 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.335532e-01 0.363 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.834043e-01 0.548 0 0
Regulation of beta-cell development R-HSA-186712 2.620721e-01 0.582 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.606017e-01 0.584 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.151366e-01 0.667 0 0
DCC mediated attractive signaling R-HSA-418885 3.437928e-01 0.464 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.673479e-01 0.776 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.606017e-01 0.584 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.673479e-01 0.776 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.673479e-01 0.776 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.227620e-01 0.652 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 3.192746e-01 0.496 0 0
Muscarinic acetylcholine receptors R-HSA-390648 3.615485e-01 0.442 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.735885e-01 0.563 0 0
Pervasive developmental disorders R-HSA-9005895 2.735885e-01 0.563 0 0
Disorders of Nervous System Development R-HSA-9697154 2.735885e-01 0.563 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.011996e-01 0.397 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.799707e-01 0.420 0 0
Muscle contraction R-HSA-397014 1.697855e-01 0.770 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.528654e-01 0.597 0 0
Signaling by FGFR in disease R-HSA-1226099 4.288321e-01 0.368 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.517907e-01 0.454 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.640067e-01 0.785 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.205632e-01 0.494 0 0
Activation of BH3-only proteins R-HSA-114452 4.059468e-01 0.392 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.894064e-01 0.410 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.311882e-01 0.365 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.842524e-01 0.546 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.084805e-01 0.511 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.192746e-01 0.496 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.031410e-01 0.692 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.500054e-01 0.602 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.845646e-01 0.734 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 4.011996e-01 0.397 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.437928e-01 0.464 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.894064e-01 0.410 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.116848e-01 0.385 0 0
Downstream signal transduction R-HSA-186763 2.151366e-01 0.667 0 0
PLC beta mediated events R-HSA-112043 4.532097e-01 0.344 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.727852e-01 0.564 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.974610e-01 0.705 0 0
Sensory processing of sound R-HSA-9659379 1.994564e-01 0.700 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.835044e-01 0.416 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.872747e-01 0.412 0 0
L1CAM interactions R-HSA-373760 3.248981e-01 0.488 0 0
Gap junction trafficking and regulation R-HSA-157858 3.036031e-01 0.518 0 0
Suppression of apoptosis R-HSA-9635465 2.264857e-01 0.645 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.890153e-01 0.724 0 0
TBC/RABGAPs R-HSA-8854214 2.314704e-01 0.636 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.314913e-01 0.635 1 0
Regulation of signaling by CBL R-HSA-912631 4.549766e-01 0.342 0 0
Rap1 signalling R-HSA-392517 4.549766e-01 0.342 0 0
DAG and IP3 signaling R-HSA-1489509 4.410499e-01 0.356 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.838315e-01 0.416 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.256196e-01 0.371 0 0
The NLRP3 inflammasome R-HSA-844456 4.549766e-01 0.342 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.667542e-01 0.778 0 0
Interferon Signaling R-HSA-913531 2.938474e-01 0.532 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.299616e-01 0.482 0 0
Collagen degradation R-HSA-1442490 4.532097e-01 0.344 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.549766e-01 0.342 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.800972e-01 0.744 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.800972e-01 0.744 0 0
Regulation of KIT signaling R-HSA-1433559 3.205632e-01 0.494 0 0
CREB phosphorylation R-HSA-199920 4.383903e-01 0.358 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.758312e-01 0.755 0 0
Differentiation of T cells R-HSA-9945266 3.667595e-01 0.436 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 3.667595e-01 0.436 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.306563e-01 0.637 0 0
FLT3 signaling in disease R-HSA-9682385 2.981640e-01 0.526 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.338305e-01 0.631 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.370838e-01 0.472 0 0
Signaling by PDGF R-HSA-186797 2.945090e-01 0.531 0 0
Maturation of nucleoprotein R-HSA-9683610 2.971366e-01 0.527 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.116848e-01 0.385 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.800972e-01 0.744 0 0
Myogenesis R-HSA-525793 3.370838e-01 0.472 0 0
Tie2 Signaling R-HSA-210993 4.335532e-01 0.363 0 0
PI Metabolism R-HSA-1483255 4.374037e-01 0.359 0 0
Specification of primordial germ cells R-HSA-9827857 4.116848e-01 0.385 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.562857e-01 0.591 0 0
Netrin-1 signaling R-HSA-373752 4.269591e-01 0.370 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.615485e-01 0.442 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.688075e-01 0.773 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.011996e-01 0.397 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.507519e-01 0.601 0 0
HDL clearance R-HSA-8964011 4.383903e-01 0.358 0 0
Formation of the anterior neural plate R-HSA-9823739 3.437928e-01 0.464 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.116848e-01 0.385 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.838315e-01 0.416 0 0
Gap junction trafficking R-HSA-190828 4.269591e-01 0.370 0 0
Mitochondrial biogenesis R-HSA-1592230 3.331740e-01 0.477 0 0
Signaling by TGFB family members R-HSA-9006936 3.562431e-01 0.448 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.054984e-01 0.515 0 0
Signaling by PTK6 R-HSA-8848021 3.054984e-01 0.515 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.072942e-01 0.683 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 4.011996e-01 0.397 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.667595e-01 0.436 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.544182e-01 0.450 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.264857e-01 0.645 0 0
Signaling by SCF-KIT R-HSA-1433557 4.127786e-01 0.384 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.507519e-01 0.601 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.437928e-01 0.464 0 0
Maturation of nucleoprotein R-HSA-9694631 4.549766e-01 0.342 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.431631e-01 0.614 0 0
RMTs methylate histone arginines R-HSA-3214858 2.431631e-01 0.614 0 0
OAS antiviral response R-HSA-8983711 2.735885e-01 0.563 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.981640e-01 0.526 1 1
Glycolysis R-HSA-70171 1.805352e-01 0.743 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.667595e-01 0.436 0 0
Mismatch Repair R-HSA-5358508 4.335532e-01 0.363 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.894064e-01 0.410 0 0
Signaling by Leptin R-HSA-2586552 2.031410e-01 0.692 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.985240e-01 0.400 0 0
Interleukin-7 signaling R-HSA-1266695 3.197230e-01 0.495 0 0
Glucose metabolism R-HSA-70326 3.331740e-01 0.477 0 0
Interleukin-37 signaling R-HSA-9008059 2.019496e-01 0.695 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.550362e-01 0.342 0 0
Integrin signaling R-HSA-354192 4.561909e-01 0.341 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.561909e-01 0.341 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.561909e-01 0.341 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.561909e-01 0.341 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.561909e-01 0.341 0 0
Rab regulation of trafficking R-HSA-9007101 4.627008e-01 0.335 0 0
RSV-host interactions R-HSA-9833110 4.659247e-01 0.332 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.725459e-01 0.326 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.725459e-01 0.326 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 4.732733e-01 0.325 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.732733e-01 0.325 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 4.732733e-01 0.325 0 0
Disinhibition of SNARE formation R-HSA-114516 4.732733e-01 0.325 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.732733e-01 0.325 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.732733e-01 0.325 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.732733e-01 0.325 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 4.732733e-01 0.325 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.732733e-01 0.325 0 0
Regulation of PTEN localization R-HSA-8948747 4.732733e-01 0.325 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.732733e-01 0.325 0 0
CHL1 interactions R-HSA-447041 4.732733e-01 0.325 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.732733e-01 0.325 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.732892e-01 0.325 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.759259e-01 0.322 0 0
Nephrin family interactions R-HSA-373753 4.759259e-01 0.322 0 0
Negative regulation of MET activity R-HSA-6807004 4.759259e-01 0.322 0 0
Signaling by NODAL R-HSA-1181150 4.759259e-01 0.322 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.826409e-01 0.316 0 0
Co-stimulation by CD28 R-HSA-389356 4.826409e-01 0.316 1 0
Signaling by Interleukins R-HSA-449147 4.839835e-01 0.315 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.886727e-01 0.311 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.886727e-01 0.311 0 0
Signaling by NOTCH2 R-HSA-1980145 4.886727e-01 0.311 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.896187e-01 0.310 0 0
IGF1R signaling cascade R-HSA-2428924 4.897019e-01 0.310 0 0
PKR-mediated signaling R-HSA-9833482 4.951572e-01 0.305 0 0
DNA Damage Bypass R-HSA-73893 4.962343e-01 0.304 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.963774e-01 0.304 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 4.963774e-01 0.304 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.963774e-01 0.304 0 0
Signalling to RAS R-HSA-167044 4.963774e-01 0.304 0 0
ERK/MAPK targets R-HSA-198753 4.963774e-01 0.304 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.016732e-01 0.300 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.024985e-01 0.299 1 0
Influenza Infection R-HSA-168255 5.028456e-01 0.299 0 0
PERK regulates gene expression R-HSA-381042 5.045551e-01 0.297 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 5.059916e-01 0.296 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.059916e-01 0.296 0 0
MET receptor recycling R-HSA-8875656 5.059916e-01 0.296 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.059916e-01 0.296 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 5.059916e-01 0.296 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 5.059916e-01 0.296 0 0
Adrenoceptors R-HSA-390696 5.059916e-01 0.296 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 5.059916e-01 0.296 0 0
FGFR1b ligand binding and activation R-HSA-190370 5.059916e-01 0.296 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 5.059916e-01 0.296 0 0
TGFBR3 PTM regulation R-HSA-9839383 5.059916e-01 0.296 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.059916e-01 0.296 0 0
Sodium/Proton exchangers R-HSA-425986 5.059916e-01 0.296 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.096733e-01 0.293 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.096733e-01 0.293 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.126983e-01 0.290 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.163121e-01 0.287 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.163121e-01 0.287 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.167109e-01 0.287 0 0
G1/S-Specific Transcription R-HSA-69205 5.201784e-01 0.284 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.201784e-01 0.284 0 0
RNA Polymerase III Transcription R-HSA-74158 5.201784e-01 0.284 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.201784e-01 0.284 0 0
Calmodulin induced events R-HSA-111933 5.201784e-01 0.284 0 0
CaM pathway R-HSA-111997 5.201784e-01 0.284 0 0
DNA Double Strand Break Response R-HSA-5693606 5.252767e-01 0.280 0 0
G-protein mediated events R-HSA-112040 5.252767e-01 0.280 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.261656e-01 0.279 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.262355e-01 0.279 0 0
Degradation of DVL R-HSA-4641258 5.355298e-01 0.271 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.355298e-01 0.271 0 0
FGFR2 alternative splicing R-HSA-6803529 5.357154e-01 0.271 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.357154e-01 0.271 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.357154e-01 0.271 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.357154e-01 0.271 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.357154e-01 0.271 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.357154e-01 0.271 0 0
DNA Replication R-HSA-69306 5.358157e-01 0.271 0 0
Orc1 removal from chromatin R-HSA-68949 5.360471e-01 0.271 0 0
Neurexins and neuroligins R-HSA-6794361 5.360471e-01 0.271 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.360471e-01 0.271 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.360471e-01 0.271 0 0
ALK mutants bind TKIs R-HSA-9700645 5.366794e-01 0.270 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.366794e-01 0.270 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.366794e-01 0.270 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.366794e-01 0.270 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.366794e-01 0.270 0 0
mRNA Editing R-HSA-75072 5.366794e-01 0.270 0 0
Regulation of signaling by NODAL R-HSA-1433617 5.366794e-01 0.270 0 0
Interleukin-1 processing R-HSA-448706 5.366794e-01 0.270 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.366794e-01 0.270 0 0
Regulated proteolysis of p75NTR R-HSA-193692 5.366794e-01 0.270 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.366794e-01 0.270 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.366794e-01 0.270 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.379007e-01 0.269 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.389865e-01 0.268 0 0
Co-inhibition by PD-1 R-HSA-389948 5.400231e-01 0.268 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.412457e-01 0.267 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.412457e-01 0.267 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.412457e-01 0.267 0 0
Developmental Cell Lineages R-HSA-9734767 5.450378e-01 0.264 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.483789e-01 0.261 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.489637e-01 0.260 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.489637e-01 0.260 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.489637e-01 0.260 0 0
PPARA activates gene expression R-HSA-1989781 5.511659e-01 0.259 0 0
G2/M Transition R-HSA-69275 5.527684e-01 0.257 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.545763e-01 0.256 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.545763e-01 0.256 0 0
Syndecan interactions R-HSA-3000170 5.545763e-01 0.256 0 0
Growth hormone receptor signaling R-HSA-982772 5.545763e-01 0.256 0 0
DNA Repair R-HSA-73894 5.568742e-01 0.254 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.592326e-01 0.252 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.597254e-01 0.252 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.616894e-01 0.251 0 0
HCMV Infection R-HSA-9609646 5.622523e-01 0.250 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.653735e-01 0.248 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.654626e-01 0.248 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.654626e-01 0.248 0 0
DNA replication initiation R-HSA-68952 5.654626e-01 0.248 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.654626e-01 0.248 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.654626e-01 0.248 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.654626e-01 0.248 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.654626e-01 0.248 0 0
Pexophagy R-HSA-9664873 5.654626e-01 0.248 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.654626e-01 0.248 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.654626e-01 0.248 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.654626e-01 0.248 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.654626e-01 0.248 0 0
Josephin domain DUBs R-HSA-5689877 5.654626e-01 0.248 0 0
Regulation of CDH11 function R-HSA-9762292 5.654626e-01 0.248 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.709275e-01 0.243 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.728874e-01 0.242 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.798476e-01 0.237 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.798476e-01 0.237 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.798476e-01 0.237 0 0
Diseases of Immune System R-HSA-5260271 5.798476e-01 0.237 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.798476e-01 0.237 0 0
Generation of second messenger molecules R-HSA-202433 5.798476e-01 0.237 0 0
Interleukin-2 family signaling R-HSA-451927 5.798476e-01 0.237 0 0
Cilium Assembly R-HSA-5617833 5.804817e-01 0.236 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.819799e-01 0.235 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.820952e-01 0.235 0 0
Signaling by FGFR1 R-HSA-5654736 5.865397e-01 0.232 0 0
Toll-like Receptor Cascades R-HSA-168898 5.872996e-01 0.231 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.906442e-01 0.229 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.906442e-01 0.229 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.906442e-01 0.229 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.906442e-01 0.229 0 0
Deubiquitination R-HSA-5688426 5.923397e-01 0.227 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.924593e-01 0.227 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.924593e-01 0.227 0 0
Bicarbonate transporters R-HSA-425381 5.924593e-01 0.227 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.924593e-01 0.227 0 0
Interleukin-2 signaling R-HSA-9020558 5.924593e-01 0.227 0 0
Ca2+ pathway R-HSA-4086398 5.928776e-01 0.227 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.940134e-01 0.226 1 1
FLT3 Signaling R-HSA-9607240 5.940134e-01 0.226 0 0
Maturation of spike protein R-HSA-9694548 5.940134e-01 0.226 0 0
IRS-mediated signalling R-HSA-112399 5.986522e-01 0.223 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.078448e-01 0.216 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.078448e-01 0.216 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.078448e-01 0.216 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.078651e-01 0.216 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.078651e-01 0.216 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.141915e-01 0.212 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.177802e-01 0.209 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.177802e-01 0.209 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.177802e-01 0.209 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.177802e-01 0.209 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.177802e-01 0.209 0 0
Anchoring fibril formation R-HSA-2214320 6.177802e-01 0.209 0 0
Ca-dependent events R-HSA-111996 6.213981e-01 0.207 0 0
Extension of Telomeres R-HSA-180786 6.222267e-01 0.206 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.244898e-01 0.204 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.244898e-01 0.204 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.244898e-01 0.204 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.244898e-01 0.204 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.244898e-01 0.204 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.244898e-01 0.204 1 1
Signaling by FGFR4 R-HSA-5654743 6.346090e-01 0.197 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.346570e-01 0.197 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.348379e-01 0.197 0 0
Translation of Structural Proteins R-HSA-9694635 6.348379e-01 0.197 0 0
SLC transporter disorders R-HSA-5619102 6.386659e-01 0.195 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 6.405819e-01 0.193 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.405819e-01 0.193 0 0
Inflammasomes R-HSA-622312 6.405819e-01 0.193 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.415294e-01 0.193 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.415294e-01 0.193 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.415294e-01 0.193 0 0
Regulation of IFNG signaling R-HSA-877312 6.415294e-01 0.193 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 6.415294e-01 0.193 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.415294e-01 0.193 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.415294e-01 0.193 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.415294e-01 0.193 0 0
Interleukin-15 signaling R-HSA-8983432 6.415294e-01 0.193 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.419262e-01 0.193 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.449078e-01 0.191 0 0
Interleukin-1 family signaling R-HSA-446652 6.490841e-01 0.188 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.547922e-01 0.184 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.559057e-01 0.183 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.561255e-01 0.183 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.561255e-01 0.183 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.561255e-01 0.183 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.561255e-01 0.183 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.561622e-01 0.183 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.600551e-01 0.180 0 0
Signaling by FGFR3 R-HSA-5654741 6.600551e-01 0.180 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.638043e-01 0.178 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.638043e-01 0.178 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 6.638043e-01 0.178 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.638043e-01 0.178 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.638043e-01 0.178 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.638043e-01 0.178 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.638043e-01 0.178 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.638043e-01 0.178 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.638043e-01 0.178 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.638043e-01 0.178 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.645037e-01 0.178 0 0
Signaling by FGFR2 R-HSA-5654738 6.645037e-01 0.178 0 0
TCR signaling R-HSA-202403 6.648631e-01 0.177 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.650244e-01 0.177 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.711266e-01 0.173 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.711266e-01 0.173 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.711266e-01 0.173 0 0
Leishmania phagocytosis R-HSA-9664417 6.752115e-01 0.171 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.752115e-01 0.171 0 0
Parasite infection R-HSA-9664407 6.752115e-01 0.171 0 0
Insulin receptor signalling cascade R-HSA-74751 6.772060e-01 0.169 0 0
HCMV Late Events R-HSA-9610379 6.836526e-01 0.165 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.841944e-01 0.165 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.841944e-01 0.165 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.846963e-01 0.165 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.846963e-01 0.165 0 0
Physiological factors R-HSA-5578768 6.846963e-01 0.165 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 6.846963e-01 0.165 0 0
HDL assembly R-HSA-8963896 6.846963e-01 0.165 0 0
Signal regulatory protein family interactions R-HSA-391160 6.846963e-01 0.165 0 0
Cargo concentration in the ER R-HSA-5694530 6.855926e-01 0.164 0 0
Cellular response to hypoxia R-HSA-1234174 6.875058e-01 0.163 0 0
G2/M Checkpoints R-HSA-69481 6.887968e-01 0.162 0 0
Telomere Maintenance R-HSA-157579 6.899907e-01 0.161 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.925548e-01 0.160 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.957747e-01 0.158 0 0
Interferon gamma signaling R-HSA-877300 6.968896e-01 0.157 0 0
Signaling by FGFR R-HSA-190236 6.983048e-01 0.156 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.995321e-01 0.155 0 0
Signaling by WNT in cancer R-HSA-4791275 6.995321e-01 0.155 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.995321e-01 0.155 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.015400e-01 0.154 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.042912e-01 0.152 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.042912e-01 0.152 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.042912e-01 0.152 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.042912e-01 0.152 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.042912e-01 0.152 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.042912e-01 0.152 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.042912e-01 0.152 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.042912e-01 0.152 0 0
p38MAPK events R-HSA-171007 7.042912e-01 0.152 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.042912e-01 0.152 0 0
Protein methylation R-HSA-8876725 7.042912e-01 0.152 0 0
Meiosis R-HSA-1500620 7.103415e-01 0.149 0 0
SARS-CoV Infections R-HSA-9679506 7.104355e-01 0.148 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.118271e-01 0.148 1 1
G-protein beta:gamma signalling R-HSA-397795 7.129545e-01 0.147 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.129545e-01 0.147 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.129545e-01 0.147 0 0
PI3K Cascade R-HSA-109704 7.179647e-01 0.144 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.189589e-01 0.143 0 0
Interleukin-1 signaling R-HSA-9020702 7.223413e-01 0.141 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.226695e-01 0.141 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.226695e-01 0.141 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.226695e-01 0.141 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.226695e-01 0.141 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.226695e-01 0.141 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.226695e-01 0.141 0 0
Negative regulation of FLT3 R-HSA-9706369 7.226695e-01 0.141 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.258704e-01 0.139 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.273922e-01 0.138 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.285792e-01 0.138 0 0
Post NMDA receptor activation events R-HSA-438064 7.356416e-01 0.133 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.376019e-01 0.132 0 0
Dual Incision in GG-NER R-HSA-5696400 7.382908e-01 0.132 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.382908e-01 0.132 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.382908e-01 0.132 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.382908e-01 0.132 0 0
Mitophagy R-HSA-5205647 7.382908e-01 0.132 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.382908e-01 0.132 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.388776e-01 0.131 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.388776e-01 0.131 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.399066e-01 0.131 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.399066e-01 0.131 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.399066e-01 0.131 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.399066e-01 0.131 0 0
Fibronectin matrix formation R-HSA-1566977 7.399066e-01 0.131 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.399066e-01 0.131 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.399066e-01 0.131 0 0
Diseases of programmed cell death R-HSA-9645723 7.437076e-01 0.129 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.443879e-01 0.128 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.443879e-01 0.128 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.443879e-01 0.128 0 0
Hedgehog 'on' state R-HSA-5632684 7.443879e-01 0.128 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.488635e-01 0.126 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.502274e-01 0.125 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.502274e-01 0.125 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.502274e-01 0.125 0 0
Regulation of Apoptosis R-HSA-169911 7.502274e-01 0.125 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.502274e-01 0.125 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.560733e-01 0.121 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.560733e-01 0.121 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.560733e-01 0.121 0 0
Glycogen storage diseases R-HSA-3229121 7.560733e-01 0.121 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.560733e-01 0.121 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.560733e-01 0.121 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.560733e-01 0.121 0 0
Base Excision Repair R-HSA-73884 7.592919e-01 0.120 0 0
Chromosome Maintenance R-HSA-73886 7.607771e-01 0.119 0 0
Glycosphingolipid transport R-HSA-9845576 7.616923e-01 0.118 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.616923e-01 0.118 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.663178e-01 0.116 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.668122e-01 0.115 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.679153e-01 0.115 0 0
G alpha (z) signalling events R-HSA-418597 7.679153e-01 0.115 0 0
tRNA processing R-HSA-72306 7.688602e-01 0.114 0 0
Signaling by ERBB4 R-HSA-1236394 7.697105e-01 0.114 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.712361e-01 0.113 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.712361e-01 0.113 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.712361e-01 0.113 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.712361e-01 0.113 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.712361e-01 0.113 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.712361e-01 0.113 0 0
Platelet sensitization by LDL R-HSA-432142 7.712361e-01 0.113 0 0
GAB1 signalosome R-HSA-180292 7.712361e-01 0.113 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.712361e-01 0.113 0 0
SLC-mediated transport of organic cations R-HSA-549127 7.726980e-01 0.112 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.769904e-01 0.110 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.769904e-01 0.110 0 0
Protein ubiquitination R-HSA-8852135 7.777013e-01 0.109 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.813154e-01 0.107 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.832573e-01 0.106 0 0
Vesicle-mediated transport R-HSA-5653656 7.838296e-01 0.106 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.854572e-01 0.105 0 0
Crosslinking of collagen fibrils R-HSA-2243919 7.854572e-01 0.105 0 0
Pyrimidine biosynthesis R-HSA-500753 7.854572e-01 0.105 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.854572e-01 0.105 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.854572e-01 0.105 0 0
Diseases of hemostasis R-HSA-9671793 7.854572e-01 0.105 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.854572e-01 0.105 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.854714e-01 0.105 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.933594e-01 0.101 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.933832e-01 0.101 0 0
Dual incision in TC-NER R-HSA-6782135 7.942648e-01 0.100 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.942648e-01 0.100 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.987950e-01 0.098 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.987950e-01 0.098 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.987950e-01 0.098 0 0
Glycogen synthesis R-HSA-3322077 7.987950e-01 0.098 0 0
Creatine metabolism R-HSA-71288 7.987950e-01 0.098 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.987950e-01 0.098 0 0
Protein hydroxylation R-HSA-9629569 7.987950e-01 0.098 0 0
Signal transduction by L1 R-HSA-445144 7.987950e-01 0.098 0 0
RNA Polymerase I Transcription R-HSA-73864 8.003604e-01 0.097 0 0
Extracellular matrix organization R-HSA-1474244 8.003607e-01 0.097 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.030886e-01 0.095 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.030886e-01 0.095 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.030886e-01 0.095 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.030886e-01 0.095 0 0
Glycogen metabolism R-HSA-8982491 8.030886e-01 0.095 0 0
Platelet degranulation R-HSA-114608 8.034219e-01 0.095 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.049093e-01 0.094 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.113044e-01 0.091 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.113044e-01 0.091 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.113044e-01 0.091 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.113044e-01 0.091 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.113044e-01 0.091 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.113044e-01 0.091 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.113044e-01 0.091 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.113044e-01 0.091 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 8.113044e-01 0.091 0 0
Basigin interactions R-HSA-210991 8.113044e-01 0.091 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.113044e-01 0.091 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.123868e-01 0.090 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.123868e-01 0.090 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.123868e-01 0.090 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.145155e-01 0.089 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.198198e-01 0.086 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.212908e-01 0.086 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.212908e-01 0.086 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.212908e-01 0.086 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.212908e-01 0.086 0 0
Translation of Structural Proteins R-HSA-9683701 8.212908e-01 0.086 0 0
Cellular response to chemical stress R-HSA-9711123 8.227127e-01 0.085 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.230367e-01 0.085 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.230367e-01 0.085 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.230367e-01 0.085 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.230367e-01 0.085 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.230367e-01 0.085 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.230367e-01 0.085 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.230367e-01 0.085 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.230367e-01 0.085 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.230367e-01 0.085 0 0
Reproduction R-HSA-1474165 8.250427e-01 0.084 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.254681e-01 0.083 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.285191e-01 0.082 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.298136e-01 0.081 0 0
Depyrimidination R-HSA-73928 8.298136e-01 0.081 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.326067e-01 0.080 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.340403e-01 0.079 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.340403e-01 0.079 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.340403e-01 0.079 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.340403e-01 0.079 0 0
LDL clearance R-HSA-8964038 8.340403e-01 0.079 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.340403e-01 0.079 0 0
Signaling by KIT in disease R-HSA-9669938 8.340403e-01 0.079 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.340403e-01 0.079 0 0
Gastrulation R-HSA-9758941 8.379276e-01 0.077 0 0
Response of Mtb to phagocytosis R-HSA-9637690 8.379683e-01 0.077 0 0
Hedgehog 'off' state R-HSA-5610787 8.380650e-01 0.077 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.394929e-01 0.076 0 0
Potential therapeutics for SARS R-HSA-9679191 8.424771e-01 0.074 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.443337e-01 0.073 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.443602e-01 0.073 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.443602e-01 0.073 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.443602e-01 0.073 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.443602e-01 0.073 0 0
Organic anion transport by SLCO transporters R-HSA-879518 8.443602e-01 0.073 0 0
Carnitine shuttle R-HSA-200425 8.443602e-01 0.073 0 0
Amine ligand-binding receptors R-HSA-375280 8.457676e-01 0.073 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.488885e-01 0.071 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.532242e-01 0.069 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.540391e-01 0.069 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.540391e-01 0.069 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.540391e-01 0.069 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.540391e-01 0.069 0 0
Opioid Signalling R-HSA-111885 8.591056e-01 0.066 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.603505e-01 0.065 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.603505e-01 0.065 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.603505e-01 0.065 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.603505e-01 0.065 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.626633e-01 0.064 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.631165e-01 0.064 0 0
Long-term potentiation R-HSA-9620244 8.631165e-01 0.064 0 0
Tight junction interactions R-HSA-420029 8.631165e-01 0.064 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 8.631165e-01 0.064 0 0
Hyaluronan degradation R-HSA-2160916 8.631165e-01 0.064 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.631165e-01 0.064 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.631165e-01 0.064 0 0
Laminin interactions R-HSA-3000157 8.631165e-01 0.064 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.631165e-01 0.064 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.631165e-01 0.064 0 0
Formation of the nephric duct R-HSA-9830364 8.631165e-01 0.064 0 0
Leishmania infection R-HSA-9658195 8.669592e-01 0.062 0 0
Parasitic Infection Pathways R-HSA-9824443 8.669592e-01 0.062 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.671588e-01 0.062 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.699707e-01 0.060 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.713581e-01 0.060 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.716300e-01 0.060 0 0
MET activates PTK2 signaling R-HSA-8874081 8.716300e-01 0.060 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.716300e-01 0.060 0 0
Metalloprotease DUBs R-HSA-5689901 8.716300e-01 0.060 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.716300e-01 0.060 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.728582e-01 0.059 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.728582e-01 0.059 0 0
ER-Phagosome pathway R-HSA-1236974 8.729048e-01 0.059 0 0
Platelet homeostasis R-HSA-418346 8.733426e-01 0.059 0 0
Formation of the cornified envelope R-HSA-6809371 8.755805e-01 0.058 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.758614e-01 0.058 0 0
COPII-mediated vesicle transport R-HSA-204005 8.758614e-01 0.058 0 0
Downstream TCR signaling R-HSA-202424 8.777738e-01 0.057 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.796144e-01 0.056 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 8.796144e-01 0.056 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.796144e-01 0.056 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.796144e-01 0.056 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.796144e-01 0.056 0 0
Insulin processing R-HSA-264876 8.796144e-01 0.056 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.811572e-01 0.055 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.821410e-01 0.054 0 0
Telomere Extension By Telomerase R-HSA-171319 8.871027e-01 0.052 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.871027e-01 0.052 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.871027e-01 0.052 0 0
Signaling by Insulin receptor R-HSA-74752 8.914224e-01 0.050 0 0
Protein folding R-HSA-391251 8.914224e-01 0.050 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.914224e-01 0.050 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.914469e-01 0.050 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.941256e-01 0.049 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.956658e-01 0.048 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.958569e-01 0.048 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.968392e-01 0.047 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.968392e-01 0.047 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.968392e-01 0.047 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.997627e-01 0.046 0 0
DAP12 signaling R-HSA-2424491 9.007120e-01 0.045 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.007120e-01 0.045 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.019811e-01 0.045 1 1
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.025123e-01 0.045 0 0
Translation initiation complex formation R-HSA-72649 9.068830e-01 0.042 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.068830e-01 0.042 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.068891e-01 0.042 0 0
Budding and maturation of HIV virion R-HSA-162588 9.068891e-01 0.042 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.068891e-01 0.042 0 0
Cardiac conduction R-HSA-5576891 9.085917e-01 0.042 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.115548e-01 0.040 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.117455e-01 0.040 0 0
Viral Infection Pathways R-HSA-9824446 9.122637e-01 0.040 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.126822e-01 0.040 0 0
Integrin cell surface interactions R-HSA-216083 9.129088e-01 0.040 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.160062e-01 0.038 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.181152e-01 0.037 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.181152e-01 0.037 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.181152e-01 0.037 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.209472e-01 0.036 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.232104e-01 0.035 0 0
Resolution of D-Loop Structures R-HSA-5693537 9.232104e-01 0.035 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.232104e-01 0.035 0 0
Homology Directed Repair R-HSA-5693538 9.246533e-01 0.034 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.277287e-01 0.033 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.279889e-01 0.032 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.279889e-01 0.032 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.279889e-01 0.032 0 0
Hyaluronan metabolism R-HSA-2142845 9.279889e-01 0.032 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.279889e-01 0.032 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.279889e-01 0.032 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.279889e-01 0.032 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.317890e-01 0.031 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.324704e-01 0.030 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.324704e-01 0.030 0 0
Adaptive Immune System R-HSA-1280218 9.346553e-01 0.029 1 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.362557e-01 0.029 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.362557e-01 0.029 1 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.366731e-01 0.028 0 0
GPVI-mediated activation cascade R-HSA-114604 9.366731e-01 0.028 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.366731e-01 0.028 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.366731e-01 0.028 0 0
MHC class II antigen presentation R-HSA-2132295 9.379185e-01 0.028 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.385858e-01 0.028 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.385858e-01 0.028 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.396188e-01 0.027 0 0
Voltage gated Potassium channels R-HSA-1296072 9.406146e-01 0.027 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.406146e-01 0.027 0 0
Degradation of AXIN R-HSA-4641257 9.406146e-01 0.027 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.406146e-01 0.027 0 0
NCAM1 interactions R-HSA-419037 9.406146e-01 0.027 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.443110e-01 0.025 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.443110e-01 0.025 0 0
Ion transport by P-type ATPases R-HSA-936837 9.447364e-01 0.025 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.475874e-01 0.023 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.477774e-01 0.023 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.477774e-01 0.023 0 0
Stabilization of p53 R-HSA-69541 9.477774e-01 0.023 0 0
Pentose phosphate pathway R-HSA-71336 9.477774e-01 0.023 0 0
RAS processing R-HSA-9648002 9.477774e-01 0.023 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.510284e-01 0.022 0 0
Neurotransmitter release cycle R-HSA-112310 9.522281e-01 0.021 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.528741e-01 0.021 0 0
Nicotinate metabolism R-HSA-196807 9.528741e-01 0.021 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.540771e-01 0.020 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.540771e-01 0.020 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.540771e-01 0.020 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.569362e-01 0.019 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.569362e-01 0.019 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.569362e-01 0.019 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.596174e-01 0.018 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 9.602595e-01 0.018 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.602595e-01 0.018 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.609336e-01 0.017 0 0
ECM proteoglycans R-HSA-3000178 9.619582e-01 0.017 0 0
Defective pyroptosis R-HSA-9710421 9.621319e-01 0.017 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.621319e-01 0.017 0 0
DAP12 interactions R-HSA-2172127 9.644899e-01 0.016 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.644899e-01 0.016 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.644899e-01 0.016 0 0
Proteasome assembly R-HSA-9907900 9.644899e-01 0.016 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.644899e-01 0.016 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.651720e-01 0.015 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.666798e-01 0.015 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.666798e-01 0.015 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.667013e-01 0.015 0 0
Nucleosome assembly R-HSA-774815 9.667013e-01 0.015 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.667013e-01 0.015 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.667013e-01 0.015 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.667013e-01 0.015 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.667013e-01 0.015 0 0
Somitogenesis R-HSA-9824272 9.667013e-01 0.015 0 0
Integration of energy metabolism R-HSA-163685 9.674281e-01 0.014 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.687750e-01 0.014 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.687750e-01 0.014 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.687750e-01 0.014 0 0
Cellular response to starvation R-HSA-9711097 9.689440e-01 0.014 1 0
Signaling by Hedgehog R-HSA-5358351 9.700260e-01 0.013 0 0
Synthesis of PC R-HSA-1483191 9.707198e-01 0.013 0 0
Interleukin-12 signaling R-HSA-9020591 9.709672e-01 0.013 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.718927e-01 0.012 0 0
Metal ion SLC transporters R-HSA-425410 9.725435e-01 0.012 0 0
Degradation of CDH1 R-HSA-9766229 9.742537e-01 0.011 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.742537e-01 0.011 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.742537e-01 0.011 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.742537e-01 0.011 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.753446e-01 0.011 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.766565e-01 0.010 1 1
Complex IV assembly R-HSA-9864848 9.773615e-01 0.010 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.773615e-01 0.010 0 0
The phototransduction cascade R-HSA-2514856 9.773615e-01 0.010 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.779008e-01 0.010 0 0
Nucleotide biosynthesis R-HSA-8956320 9.800945e-01 0.009 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.800945e-01 0.009 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.801995e-01 0.009 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.815423e-01 0.008 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.827941e-01 0.008 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.827941e-01 0.008 0 0
Stimuli-sensing channels R-HSA-2672351 9.827941e-01 0.008 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.835884e-01 0.007 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.841823e-01 0.007 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.841823e-01 0.007 0 0
Synthesis of PA R-HSA-1483166 9.846112e-01 0.007 0 0
Pyruvate metabolism R-HSA-70268 9.849776e-01 0.007 0 0
Interleukin-12 family signaling R-HSA-447115 9.849776e-01 0.007 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.855702e-01 0.006 0 0
Peroxisomal protein import R-HSA-9033241 9.864696e-01 0.006 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.864696e-01 0.006 0 0
Metabolism of polyamines R-HSA-351202 9.873129e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.873129e-01 0.006 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.895408e-01 0.005 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.895408e-01 0.005 0 0
Phospholipid metabolism R-HSA-1483257 9.907507e-01 0.004 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.909094e-01 0.004 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.912949e-01 0.004 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.914061e-01 0.004 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.914061e-01 0.004 0 0
Potassium Channels R-HSA-1296071 9.918763e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.919153e-01 0.004 0 0
Kidney development R-HSA-9830369 9.919153e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.924127e-01 0.003 0 0
Regulated Necrosis R-HSA-5218859 9.924195e-01 0.003 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.927424e-01 0.003 0 0
Regulation of insulin secretion R-HSA-422356 9.927424e-01 0.003 0 0
Transmission across Chemical Synapses R-HSA-112315 9.927712e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.933355e-01 0.003 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.933355e-01 0.003 0 0
Neuronal System R-HSA-112316 9.935525e-01 0.003 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.945065e-01 0.002 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.948190e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.948492e-01 0.002 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.958859e-01 0.002 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.959019e-01 0.002 0 0
ABC transporter disorders R-HSA-5619084 9.960193e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.960193e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.960193e-01 0.002 0 0
Keratinization R-HSA-6805567 9.961950e-01 0.002 0 0
Amyloid fiber formation R-HSA-977225 9.967190e-01 0.001 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.969095e-01 0.001 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.969095e-01 0.001 0 0
Ribosome-associated quality control R-HSA-9948299 9.971663e-01 0.001 0 0
Ion channel transport R-HSA-983712 9.971807e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.973987e-01 0.001 0 0
Neutrophil degranulation R-HSA-6798695 9.974828e-01 0.001 0 0
Immune System R-HSA-168256 9.975899e-01 0.001 1 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.976817e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.976817e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.977713e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.979342e-01 0.001 0 0
Peptide chain elongation R-HSA-156902 9.980409e-01 0.001 0 0
Neddylation R-HSA-8951664 9.980630e-01 0.001 0 0
Ub-specific processing proteases R-HSA-5689880 9.982672e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.983609e-01 0.001 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.983855e-01 0.001 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.984863e-01 0.001 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.985809e-01 0.001 0 0
Protein localization R-HSA-9609507 9.987960e-01 0.001 0 0
rRNA processing R-HSA-72312 9.988323e-01 0.001 0 0
Hemostasis R-HSA-109582 9.988941e-01 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 9.989036e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.989721e-01 0.000 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.989721e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.990749e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.991530e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.991578e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.992059e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.992556e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.992595e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.993457e-01 0.000 0 0
Disease R-HSA-1643685 9.993519e-01 0.000 1 0
Bile acid and bile salt metabolism R-HSA-194068 9.996096e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.996341e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.997420e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.998519e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.998519e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.998856e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998891e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999113e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999159e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999198e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999224e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999284e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999362e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999497e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999758e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999801e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999806e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999825e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999920e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999946e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999950e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999958e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999958e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999970e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999970e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999982e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999982e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999989e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999989e-01 0.000 0 0
Translation R-HSA-72766 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways