DAPK3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O14950 S20 GPS6|SIGNOR|EPSD|PSP MYL12B MRLC2 MYLC2B _MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
O14950 T19 GPS6|SIGNOR|EPSD|PSP MYL12B MRLC2 MYLC2B __MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
O14974 T696 GPS6|EPSD PPP1R12A MBS MYPT1 EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O43293 S311 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP DAPK3 ZIPK KPERRRLKtTRLKEYtIKsHssLPPNNsYADFERFsKVLEE
O43293 S371 Sugiyama DAPK3 ZIPK EDVEALAAIYEEKEAWYREEsDSLGQDLRRLRQELLKTEAL
O43293 S407 Sugiyama DAPK3 ZIPK KTEALKRQAQEEAKGALLGTsGLKRRFSRLENRYEALAKQV
O43293 S50 EPSD DAPK3 ZIPK CRQKGTGKEYAAKFIKKRRLsSSRRGVSREEIEREVNILRE
O43293 T180 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP DAPK3 ZIPK IDFGIAHKIEAGNEFKNIFGtPEFVAPEIVNYEPLGLEADM
O43293 T225 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP DAPK3 ZIPK VITYILLSGASPFLGETKQEtLTNISAVNYDFDEEYFSNTS
O43293 T265 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP DAPK3 ZIPK SELAKDFIRRLLVKDPKRRMtIAQSLEHSWIKAIRRRNVRG
O43293 T299 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP DAPK3 ZIPK RRRNVRGEDSGRKPERRRLKtTRLKEYtIKsHssLPPNNsY
O43293 T306 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP DAPK3 ZIPK EDSGRKPERRRLKtTRLKEYtIKsHssLPPNNsYADFERFs
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
P00558 S415 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGGAsLELLEGKVLPGVDALsNI__________________
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04637 S20 SIGNOR|EPSD|PSP TP53 P53 _MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P08758 T111 Sugiyama ANXA5 ANX5 ENX2 PP4 yDAyELKHALKGAGTNEKVLtEIIAsRtPEELRAIKQVyEE
P10809 T422 Sugiyama HSPD1 HSP60 AVLKVGGtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGC
P11142 T47 Sugiyama HSPA8 HSC70 HSP73 HSPA10 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P15880 T202 Sugiyama RPS2 RPS4 CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P17066 T49 Sugiyama HSPA6 HSP70B' EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P24844 S20 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MYL9 MLC2 MRLC1 MYRL2 _MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P24844 T19 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MYL9 MLC2 MRLC1 MYRL2 __MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P34931 T49 Sugiyama HSPA1L EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P35579 T1745 Sugiyama MYH9 RRLEARIAQLEEELEEEQGNtELINDRLKKANLQIDQINtD
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P38936 T145 GPS6|SIGNOR|iPTMNet|EPSD|PSP CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 EQAEGsPGGPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP_
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40429 S77 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RPL13A FLRKRMNtNPSRGPyHFRAPsRIFWRTVRGMLPHKTKRGQA
P40763 S727 GPS6 STAT3 APRF KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P42677 T74 Sugiyama RPS27 MPS1 VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46783 T148 Sugiyama RPS10 RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P48741 T49 Sugiyama HSPA7 HSP70B EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P54652 T48 Sugiyama HSPA2 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62937 T157 Sugiyama PPIA CYPA NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P68431 T12 GPS6|ELM|iPTMNet|EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J _________MARtKQtARKstGGKAPRKQLATKAARKsAPA
Q00987 S166 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP MDM2 KPSSSHLVSRPstSSRRRAIsEtEENsDELsGERQRKRHKs
Q00987 S186 EPSD|PSP MDM2 sEtEENsDELsGERQRKRHKsDsISLsFDESLALCVIREIC
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q14457 S90 EPSD|PSP BECN1 GT197 IETPRQDGVSRRFIPPARMMsTEsANsFTLIGEASDGGtME
Q14669 S312 PSP TRIP12 KIAA0045 ULF PSGLQAKLASLRKSTKKRsEsPPAELPSLRRSTRQKTTGSC
Q71UM5 T74 Sugiyama RPS27L VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q96A00 S12 GPS6|ELM|iPTMNet|EPSD|PSP PPP1R14A CPI17 PPP1INL _________MAAQRLGKRVLsKLQSPSRARGPGGsPGGLQK
Q96A00 T38 EPSD|PSP PPP1R14A CPI17 PPP1INL SRARGPGGsPGGLQKRHARVtVKYDRRELQRRLDVEKWIDG
Q9NQ39 T159 Sugiyama RPS10P5 RPS10L RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9UNH5 S484 PSP CDC14A TSLSSGATVRSFSINSRLAssLGNLNAATDDPENKKTSSSS
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9Y2B0 S74 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 GsFRINPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGE
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 0.000003 5.537 0 0
Signal Transduction R-HSA-162582 0.000004 5.453 0 0
Cell Cycle Checkpoints R-HSA-69620 0.000020 4.708 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.000023 4.646 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.000043 4.368 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.000186 3.730 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.000186 3.730 0 0
Chromatin modifying enzymes R-HSA-3247509 0.000157 3.805 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.000176 3.754 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.000167 3.778 0 0
Regulation of TP53 Activity R-HSA-5633007 0.000275 3.561 0 0
Chromatin organization R-HSA-4839726 0.000371 3.431 0 0
Cellular Senescence R-HSA-2559583 0.000441 3.356 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.000437 3.360 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000428 3.369 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.000467 3.331 0 0
Semaphorin interactions R-HSA-373755 0.000525 3.280 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.000548 3.262 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.000617 3.209 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.000645 3.191 0 0
Cell Cycle, Mitotic R-HSA-69278 0.000625 3.204 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.000740 3.130 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.000928 3.032 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.000932 3.030 0 0
Apoptotic execution phase R-HSA-75153 0.000999 3.000 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.001142 2.942 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.001442 2.841 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.001758 2.755 0 0
Meiotic synapsis R-HSA-1221632 0.002270 2.644 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.002454 2.610 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.002772 2.557 0 0
Axon guidance R-HSA-422475 0.002935 2.532 0 0
Netrin-1 signaling R-HSA-373752 0.003042 2.517 0 0
Nervous system development R-HSA-9675108 0.003103 2.508 0 0
Signaling by Hippo R-HSA-2028269 0.003671 2.435 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.004012 2.397 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.004256 2.371 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.004571 2.340 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.004571 2.340 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.004464 2.350 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.005275 2.278 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.005220 2.282 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.005220 2.282 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.005275 2.278 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.005497 2.260 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.005782 2.238 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.006591 2.181 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.006591 2.181 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.006591 2.181 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.006591 2.181 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.006591 2.181 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.006612 2.180 0 0
G alpha (12/13) signalling events R-HSA-416482 0.006964 2.157 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.007156 2.145 0 0
Signaling by WNT in cancer R-HSA-4791275 0.008627 2.064 0 0
Apoptosis R-HSA-109581 0.009845 2.007 1 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.011227 1.950 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.011227 1.950 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.011227 1.950 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.011592 1.936 0 0
Meiosis R-HSA-1500620 0.011558 1.937 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.010953 1.960 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.010375 1.984 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.011522 1.938 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.011743 1.930 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.011790 1.928 0 0
HDMs demethylate histones R-HSA-3214842 0.014673 1.833 0 0
Regulation of TP53 Expression R-HSA-6804754 0.014717 1.832 0 0
RET signaling R-HSA-8853659 0.015025 1.823 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.016617 1.779 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.018155 1.741 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.017620 1.754 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.017597 1.755 0 0
Programmed Cell Death R-HSA-5357801 0.017134 1.766 1 0
Intracellular signaling by second messengers R-HSA-9006925 0.017269 1.763 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.018322 1.737 0 0
Mitotic Prometaphase R-HSA-68877 0.019715 1.705 0 0
Cell junction organization R-HSA-446728 0.020646 1.685 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.022005 1.657 0 0
Separation of Sister Chromatids R-HSA-2467813 0.022171 1.654 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 0.022321 1.651 0 0
S Phase R-HSA-69242 0.022384 1.650 0 0
Signaling by WNT R-HSA-195721 0.022445 1.649 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.022962 1.639 0 0
Signaling by APC mutants R-HSA-4839744 0.026987 1.569 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.026987 1.569 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.026987 1.569 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.026987 1.569 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.029223 1.534 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.028593 1.544 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.025547 1.593 0 0
Mitotic Anaphase R-HSA-68882 0.025855 1.587 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.028649 1.543 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.026789 1.572 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.025206 1.598 0 0
G2/M Transition R-HSA-69275 0.028655 1.543 0 0
NRAGE signals death through JNK R-HSA-193648 0.029223 1.534 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.031202 1.506 0 0
HATs acetylate histones R-HSA-3214847 0.031838 1.497 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.031522 1.501 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.032119 1.493 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.032119 1.493 0 0
Signaling by AXIN mutants R-HSA-4839735 0.032119 1.493 0 0
G1/S Transition R-HSA-69206 0.029521 1.530 0 0
G2/M Checkpoints R-HSA-69481 0.032339 1.490 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.030878 1.510 0 0
FOXO-mediated transcription R-HSA-9614085 0.031838 1.497 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.032466 1.489 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.033621 1.473 0 0
Ca2+ pathway R-HSA-4086398 0.034489 1.462 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.034626 1.461 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.038309 1.417 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.035977 1.444 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.037911 1.421 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 0.037723 1.423 0 0
Repression of WNT target genes R-HSA-4641265 0.037723 1.423 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.036625 1.436 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.038439 1.415 0 0
Reproduction R-HSA-1474165 0.038542 1.414 0 0
Signaling by ERBB4 R-HSA-1236394 0.036625 1.436 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.035701 1.447 0 0
IRS activation R-HSA-74713 0.041233 1.385 0 0
RAF activation R-HSA-5673000 0.041382 1.383 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.041986 1.377 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.043790 1.359 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 0.044560 1.351 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.044560 1.351 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 0.044560 1.351 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.045038 1.346 0 0
NGF-stimulated transcription R-HSA-9031628 0.045326 1.344 0 0
Co-stimulation by CD28 R-HSA-389356 0.045326 1.344 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.045326 1.344 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 0.052294 1.282 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.052294 1.282 0 0
M Phase R-HSA-68886 0.051721 1.286 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.052294 1.282 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.049287 1.307 0 0
Signaling by ALK in cancer R-HSA-9700206 0.049287 1.307 0 0
mRNA Splicing R-HSA-72172 0.055144 1.259 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.055518 1.256 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.057278 1.242 0 0
Formation of the anterior neural plate R-HSA-9823739 0.057278 1.242 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.057278 1.242 0 0
DNA Double Strand Break Response R-HSA-5693606 0.058758 1.231 0 0
mRNA 3'-end processing R-HSA-72187 0.059228 1.227 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.060371 1.219 0 0
TRP channels R-HSA-3295583 0.060371 1.219 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.061535 1.211 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.069165 1.160 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.064272 1.192 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.062950 1.201 0 0
Cell-Cell communication R-HSA-1500931 0.061118 1.214 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.069165 1.160 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.069165 1.160 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.065976 1.181 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.070906 1.149 0 0
Pyroptosis R-HSA-5620971 0.071842 1.144 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.072482 1.140 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.072482 1.140 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 0.072482 1.140 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.087136 1.060 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.087136 1.060 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.087136 1.060 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 0.087136 1.060 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.087136 1.060 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.087136 1.060 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 0.087136 1.060 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 0.127818 0.893 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 0.127818 0.893 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 0.127818 0.893 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.127818 0.893 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.127818 0.893 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.127818 0.893 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.166689 0.778 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.166689 0.778 0 0
Regulation of cortical dendrite branching R-HSA-8985801 0.166689 0.778 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 0.166689 0.778 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 0.166689 0.778 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.166689 0.778 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.166689 0.778 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.166689 0.778 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.166689 0.778 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.166689 0.778 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.166689 0.778 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 0.166689 0.778 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.166689 0.778 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.166689 0.778 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 0.166689 0.778 0 0
Potassium transport channels R-HSA-1296067 0.166689 0.778 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.166689 0.778 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.077065 1.113 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.077065 1.113 0 0
SOS-mediated signalling R-HSA-112412 0.077065 1.113 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.203831 0.691 0 0
Invadopodia formation R-HSA-8941237 0.203831 0.691 0 0
Activation of RAS in B cells R-HSA-1169092 0.090576 1.043 0 0
TNFR1-mediated ceramide production R-HSA-5626978 0.239318 0.621 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.239318 0.621 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.239318 0.621 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.239318 0.621 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.239318 0.621 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.239318 0.621 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.119404 0.923 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.273226 0.563 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.273226 0.563 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.273226 0.563 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 0.150116 0.824 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.150116 0.824 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.098234 1.008 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.166006 0.780 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.305625 0.515 0 0
PKB-mediated events R-HSA-109703 0.305625 0.515 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 0.305625 0.515 0 0
PDE3B signalling R-HSA-165160 0.305625 0.515 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 0.305625 0.515 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.305625 0.515 0 0
Signaling by RNF43 mutants R-HSA-5340588 0.305625 0.515 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.305625 0.515 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.107534 0.968 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.107534 0.968 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.107534 0.968 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.107534 0.968 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.107534 0.968 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.182168 0.740 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.182168 0.740 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.077965 1.108 0 0
Activation of the pre-replicative complex R-HSA-68962 0.084339 1.074 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.336581 0.473 0 0
STAT5 Activation R-HSA-9645135 0.336581 0.473 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.336581 0.473 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.336581 0.473 0 0
DCC mediated attractive signaling R-HSA-418885 0.215092 0.667 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.231756 0.635 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 0.366159 0.436 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 0.366159 0.436 0 0
Netrin mediated repulsion signals R-HSA-418886 0.366159 0.436 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.366159 0.436 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 0.366159 0.436 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 0.366159 0.436 0 0
Disinhibition of SNARE formation R-HSA-114516 0.366159 0.436 0 0
Tight junction interactions R-HSA-420029 0.169522 0.771 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.169522 0.771 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.248495 0.605 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.192078 0.717 0 0
Packaging Of Telomere Ends R-HSA-171306 0.192078 0.717 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.265270 0.576 0 0
Type I hemidesmosome assembly R-HSA-446107 0.394420 0.404 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.394420 0.404 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.098811 1.005 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.080605 1.094 0 0
Late endosomal microautophagy R-HSA-9615710 0.215328 0.667 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.169189 0.772 0 0
Centrosome maturation R-HSA-380287 0.088804 1.052 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.298783 0.525 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.421422 0.375 0 0
WNT mediated activation of DVL R-HSA-201688 0.421422 0.375 0 0
CASP8 activity is inhibited R-HSA-5218900 0.421422 0.375 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.125604 0.901 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.196186 0.707 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.332043 0.479 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.447222 0.349 0 0
Striated Muscle Contraction R-HSA-390522 0.275557 0.560 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.168315 0.774 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.234014 0.631 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.287831 0.541 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.364838 0.438 0 0
Notch-HLH transcription pathway R-HSA-350054 0.364838 0.438 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.364838 0.438 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.471874 0.326 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.471874 0.326 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.169973 0.770 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.225576 0.647 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.225576 0.647 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.312486 0.505 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.381006 0.419 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.242147 0.616 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.230659 0.637 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.293505 0.532 0 0
Activation of RAC1 R-HSA-428540 0.495427 0.305 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.303629 0.518 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.303629 0.518 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.283410 0.548 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.443749 0.353 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.458884 0.338 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.458884 0.338 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.355499 0.449 0 0
Signaling by Erythropoietin R-HSA-9006335 0.473777 0.324 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.473777 0.324 0 0
Nucleosome assembly R-HSA-774815 0.434598 0.362 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.434598 0.362 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.492781 0.307 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.211033 0.676 0 0
Formation of definitive endoderm R-HSA-9823730 0.315459 0.501 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.143640 0.843 0 0
Telomere Extension By Telomerase R-HSA-171319 0.203626 0.691 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.089280 1.049 0 0
Chromosome Maintenance R-HSA-73886 0.418442 0.378 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.180704 0.743 0 0
G0 and Early G1 R-HSA-1538133 0.251189 0.600 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.116094 0.935 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.165900 0.780 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.422655 0.374 0 0
Regulation of the apoptosome activity R-HSA-9627069 0.119404 0.923 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 0.150116 0.824 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.198547 0.702 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.447222 0.349 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.488419 0.311 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.316092 0.500 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.104717 0.980 0 0
Regulation of CDH11 function R-HSA-9762292 0.119404 0.923 0 0
Formation of apoptosome R-HSA-111458 0.119404 0.923 0 0
PI3K/AKT activation R-HSA-198203 0.119404 0.923 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.097820 1.010 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.231756 0.635 0 0
Stabilization of p53 R-HSA-69541 0.160500 0.795 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.315459 0.501 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.443749 0.353 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.089280 1.049 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.364838 0.438 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.119777 0.922 0 0
Homology Directed Repair R-HSA-5693538 0.153650 0.813 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.257442 0.589 0 0
ESR-mediated signaling R-HSA-8939211 0.201190 0.696 0 0
Adrenoceptors R-HSA-390696 0.090576 1.043 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 0.166006 0.780 0 0
Formation of axial mesoderm R-HSA-9796292 0.182168 0.740 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.215092 0.667 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 0.394420 0.404 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.209361 0.679 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.412794 0.384 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.412794 0.384 0 0
Trafficking of AMPA receptors R-HSA-399719 0.502802 0.299 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.485298 0.314 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.485298 0.314 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.494969 0.305 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.226019 0.646 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.194131 0.712 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.137318 0.862 0 0
Regulated Necrosis R-HSA-5218859 0.267574 0.573 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.126583 0.898 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.434525 0.362 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.434525 0.362 0 0
Myogenesis R-HSA-525793 0.180704 0.743 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.446449 0.350 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.446449 0.350 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.446449 0.350 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.167453 0.776 0 0
TNF signaling R-HSA-75893 0.170672 0.768 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.076677 1.115 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.136448 0.865 0 0
Formation of the posterior neural plate R-HSA-9832991 0.134561 0.871 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.150116 0.824 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.166006 0.780 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.104915 0.979 0 0
mRNA Editing: C to U Conversion R-HSA-72200 0.366159 0.436 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.227168 0.644 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.227168 0.644 0 0
Calcineurin activates NFAT R-HSA-2025928 0.421422 0.375 0 0
IRS-mediated signalling R-HSA-112399 0.178177 0.749 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.332043 0.479 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.263440 0.579 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.267574 0.573 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.412794 0.384 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.306523 0.514 0 0
Cyclin D associated events in G1 R-HSA-69231 0.422655 0.374 0 0
G1 Phase R-HSA-69236 0.422655 0.374 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.234014 0.631 0 0
Interleukin-2 signaling R-HSA-9020558 0.471874 0.326 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.124727 0.904 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.451860 0.345 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.131349 0.882 0 0
Signaling by ROBO receptors R-HSA-376176 0.142861 0.845 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.488419 0.311 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 0.239318 0.621 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.080690 1.093 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 0.305625 0.515 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 0.215092 0.667 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.187041 0.728 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.263338 0.579 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.168315 0.774 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 0.495427 0.305 0 0
Meiotic recombination R-HSA-912446 0.504065 0.298 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.076766 1.115 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.374119 0.427 0 0
DARPP-32 events R-HSA-180024 0.473777 0.324 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.336581 0.473 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.104915 0.979 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.315459 0.501 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.375105 0.426 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.375105 0.426 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.375105 0.426 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.375105 0.426 0 0
Signaling by RAS mutants R-HSA-6802949 0.446449 0.350 0 0
Circadian clock R-HSA-9909396 0.237727 0.624 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.219559 0.658 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.402544 0.395 0 0
Specification of the neural plate border R-HSA-9834899 0.098234 1.008 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.285482 0.544 0 0
IGF1R signaling cascade R-HSA-2428924 0.233820 0.631 0 0
DAP12 signaling R-HSA-2424491 0.488419 0.311 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.300259 0.523 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.165900 0.780 0 0
Unwinding of DNA R-HSA-176974 0.104717 0.980 0 0
Bicarbonate transporters R-HSA-425381 0.134561 0.871 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.273226 0.563 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.089280 1.049 0 0
Formation of the Editosome R-HSA-75094 0.305625 0.515 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.305625 0.515 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.182168 0.740 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.182168 0.740 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 0.336581 0.473 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 0.231756 0.635 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 0.366159 0.436 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.119777 0.922 0 0
Regulation by c-FLIP R-HSA-3371378 0.394420 0.404 0 0
Co-stimulation by ICOS R-HSA-9927354 0.394420 0.404 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.282044 0.550 0 0
PI3K Cascade R-HSA-109704 0.128479 0.891 0 0
Orc1 removal from chromatin R-HSA-68949 0.141971 0.848 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.421422 0.375 0 0
Budding and maturation of HIV virion R-HSA-162588 0.239127 0.621 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.447222 0.349 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 0.447222 0.349 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.275557 0.560 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.495427 0.305 0 0
ERKs are inactivated R-HSA-202670 0.495427 0.305 0 0
Cristae formation R-HSA-8949613 0.443749 0.353 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.473777 0.324 0 0
Degradation of CDH1 R-HSA-9766229 0.481372 0.318 0 0
HSF1-dependent transactivation R-HSA-3371571 0.504065 0.298 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.504861 0.297 0 0
Gastrulation R-HSA-9758941 0.492184 0.308 0 0
Insulin receptor signalling cascade R-HSA-74751 0.233820 0.631 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.242147 0.616 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.180704 0.743 1 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.514075 0.289 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.284842 0.545 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.504563 0.297 0 0
Apoptotic factor-mediated response R-HSA-111471 0.089280 1.049 0 0
Signaling by TGFB family members R-HSA-9006936 0.423381 0.373 0 0
Gene expression (Transcription) R-HSA-74160 0.221306 0.655 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.158551 0.800 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.104915 0.979 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 0.366159 0.436 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.363334 0.440 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.263338 0.579 0 0
RNA Polymerase II Transcription R-HSA-73857 0.109658 0.960 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.097532 1.011 0 0
Signaling by FGFR in disease R-HSA-1226099 0.319937 0.495 0 0
Generic Transcription Pathway R-HSA-212436 0.165745 0.781 0 0
MDK and PTN in ALK signaling R-HSA-9851151 0.239318 0.621 0 0
Signal attenuation R-HSA-74749 0.119404 0.923 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.394420 0.404 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.394420 0.404 0 0
Kinesins R-HSA-983189 0.093853 1.028 0 0
FLT3 signaling in disease R-HSA-9682385 0.135487 0.868 0 0
Neurexins and neuroligins R-HSA-6794361 0.293505 0.532 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.105610 0.976 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.105610 0.976 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 0.239318 0.621 0 0
Signaling by LTK R-HSA-9842663 0.166006 0.780 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.366159 0.436 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.366159 0.436 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 0.394420 0.404 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.151980 0.818 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 0.421422 0.375 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.447222 0.349 0 0
Heme signaling R-HSA-9707616 0.217421 0.663 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.364838 0.438 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.395504 0.403 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.364838 0.438 0 0
The NLRP3 inflammasome R-HSA-844456 0.298783 0.525 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.249824 0.602 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.169189 0.772 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.104717 0.980 1 1
Platelet calcium homeostasis R-HSA-418360 0.215328 0.667 0 0
mTORC1-mediated signalling R-HSA-166208 0.364838 0.438 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.119923 0.921 0 0
RMTs methylate histone arginines R-HSA-3214858 0.214869 0.668 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.391204 0.408 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.143640 0.843 0 0
Developmental Biology R-HSA-1266738 0.330239 0.481 0 0
Cell-cell junction organization R-HSA-421270 0.075752 1.121 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.278530 0.555 0 0
Signaling by Insulin receptor R-HSA-74752 0.496369 0.304 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.080690 1.093 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.160248 0.795 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.433100 0.363 0 0
Adherens junctions interactions R-HSA-418990 0.133519 0.874 0 0
Death Receptor Signaling R-HSA-73887 0.099572 1.002 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.127818 0.893 0 0
DSCAM interactions R-HSA-376172 0.166689 0.778 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 0.203831 0.691 0 0
Sensory perception of sour taste R-HSA-9729555 0.239318 0.621 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 0.273226 0.563 0 0
Creatine metabolism R-HSA-71288 0.107534 0.968 0 0
Ca2+ activated K+ channels R-HSA-1296052 0.366159 0.436 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.192078 0.717 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 0.394420 0.404 0 0
Dimerization of procaspase-8 R-HSA-69416 0.394420 0.404 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.447222 0.349 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.447222 0.349 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.217421 0.663 0 0
Synthesis of PI R-HSA-1483226 0.471874 0.326 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.471874 0.326 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.381006 0.419 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 0.495427 0.305 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.495427 0.305 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.431486 0.365 0 0
Cellular responses to stress R-HSA-2262752 0.482855 0.316 0 0
Smooth Muscle Contraction R-HSA-445355 0.148938 0.827 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.375105 0.426 0 0
Sensory processing of sound R-HSA-9659379 0.364423 0.438 0 0
Protein hydroxylation R-HSA-9629569 0.107534 0.968 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.394420 0.404 0 0
Ub-specific processing proteases R-HSA-5689880 0.379712 0.421 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.103905 0.983 0 0
Synthesis of DNA R-HSA-69239 0.458319 0.339 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.458200 0.339 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.477022 0.321 0 0
MAPK family signaling cascades R-HSA-5683057 0.239879 0.620 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.127530 0.894 0 0
Interleukin-37 signaling R-HSA-9008059 0.227168 0.644 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.473777 0.324 0 0
Recycling pathway of L1 R-HSA-437239 0.458200 0.339 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.281620 0.550 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.455861 0.341 0 0
Muscle contraction R-HSA-397014 0.115262 0.938 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.078405 1.106 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.252900 0.597 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.428382 0.368 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.076677 1.115 0 0
Diseases of programmed cell death R-HSA-9645723 0.158419 0.800 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.334192 0.476 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.505611 0.296 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.434598 0.362 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.415794 0.381 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.446449 0.350 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.446449 0.350 0 0
Deubiquitination R-HSA-5688426 0.485497 0.314 0 0
FLT3 Signaling R-HSA-9607240 0.178039 0.749 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.111771 0.952 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 0.203831 0.691 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.239318 0.621 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 0.273226 0.563 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 0.305625 0.515 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 0.305625 0.515 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.127095 0.896 0 0
NADPH regeneration R-HSA-389542 0.336581 0.473 0 0
Regulation of PTEN localization R-HSA-8948747 0.366159 0.436 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 0.366159 0.436 0 0
Glycoprotein hormones R-HSA-209822 0.366159 0.436 0 0
Passive transport by Aquaporins R-HSA-432047 0.248495 0.605 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.192078 0.717 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.421422 0.375 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 0.447222 0.349 0 0
Sodium/Calcium exchangers R-HSA-425561 0.495427 0.305 0 0
TGFBR3 expression R-HSA-9839394 0.412794 0.384 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.334192 0.476 0 0
Inflammasomes R-HSA-622312 0.458884 0.338 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.405665 0.392 0 0
Cellular response to hypoxia R-HSA-1234174 0.425883 0.371 0 0
Adaptive Immune System R-HSA-1280218 0.499441 0.302 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.293554 0.532 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.481862 0.317 0 0
Ion homeostasis R-HSA-5578775 0.075408 1.123 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.187041 0.728 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.332043 0.479 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.214869 0.668 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.447222 0.349 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.481862 0.317 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.442480 0.354 0 0
mRNA Editing R-HSA-75072 0.421422 0.375 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 0.421422 0.375 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.332043 0.479 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.275557 0.560 0 0
Cleavage of the damaged purine R-HSA-110331 0.324838 0.488 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.123222 0.909 0 0
Signaling by ALK R-HSA-201556 0.160500 0.795 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.263338 0.579 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.287831 0.541 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.385735 0.414 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.160500 0.795 0 0
Depurination R-HSA-73927 0.337190 0.472 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.443749 0.353 0 0
Diseases of DNA repair R-HSA-9675135 0.234014 0.631 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.090576 1.043 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.104717 0.980 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.305625 0.515 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.305625 0.515 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.215092 0.667 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 0.366159 0.436 0 0
Synthesis of PG R-HSA-1483148 0.248495 0.605 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.178039 0.749 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 0.421422 0.375 0 0
Interleukin-1 processing R-HSA-448706 0.421422 0.375 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.251189 0.600 0 0
Peptide hormone biosynthesis R-HSA-209952 0.447222 0.349 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 0.471874 0.326 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 0.471874 0.326 0 0
EPH-Ephrin signaling R-HSA-2682334 0.098727 1.006 0 0
Signaling by NTRKs R-HSA-166520 0.142428 0.846 0 0
Interleukin-7 signaling R-HSA-1266695 0.169522 0.771 0 0
Ephrin signaling R-HSA-3928664 0.282044 0.550 0 0
Cardiac conduction R-HSA-5576891 0.356551 0.448 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 0.502802 0.299 0 0
Signaling by SCF-KIT R-HSA-1433557 0.205465 0.687 0 0
G1/S-Specific Transcription R-HSA-69205 0.135487 0.868 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.374355 0.427 0 0
PI Metabolism R-HSA-1483255 0.259719 0.585 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.231756 0.635 0 0
Tandem pore domain potassium channels R-HSA-1296346 0.447222 0.349 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.225576 0.647 0 0
Signaling by VEGF R-HSA-194138 0.454987 0.342 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.298783 0.525 0 0
Stimuli-sensing channels R-HSA-2672351 0.186098 0.730 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.134561 0.871 0 0
Interleukin-1 family signaling R-HSA-446652 0.512041 0.291 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 0.182168 0.740 0 0
Cardiogenesis R-HSA-9733709 0.104915 0.979 0 0
Rap1 signalling R-HSA-392517 0.298783 0.525 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.421422 0.375 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.348510 0.458 0 0
Suppression of apoptosis R-HSA-9635465 0.471874 0.326 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.337190 0.472 0 0
Neurodegenerative Diseases R-HSA-8863678 0.158551 0.800 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.158551 0.800 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.364423 0.438 0 0
DNA strand elongation R-HSA-69190 0.516922 0.287 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.293505 0.532 0 0
Platelet sensitization by LDL R-HSA-432142 0.282044 0.550 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.421422 0.375 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.293505 0.532 0 0
Signaling by Leptin R-HSA-2586552 0.119404 0.923 0 0
Specification of primordial germ cells R-HSA-9827857 0.265270 0.576 0 0
Signaling by Interleukins R-HSA-449147 0.276323 0.559 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.282044 0.550 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.287831 0.541 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.268046 0.572 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.469843 0.328 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.080605 1.094 0 0
IRE1alpha activates chaperones R-HSA-381070 0.314669 0.502 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.398521 0.400 0 0
Depyrimidination R-HSA-73928 0.398521 0.400 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.287831 0.541 0 0
Growth hormone receptor signaling R-HSA-982772 0.381006 0.419 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.239366 0.621 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.517931 0.286 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.517931 0.286 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.517931 0.286 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.517931 0.286 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.517931 0.286 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.517931 0.286 0 0
Disorders of Nervous System Development R-HSA-9697154 0.517931 0.286 0 0
Pervasive developmental disorders R-HSA-9005895 0.517931 0.286 0 0
Interleukin-15 signaling R-HSA-8983432 0.517931 0.286 0 0
OAS antiviral response R-HSA-8983711 0.517931 0.286 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.523502 0.281 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.526234 0.279 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.526234 0.279 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.530773 0.275 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.530773 0.275 0 0
G-protein beta:gamma signalling R-HSA-397795 0.530773 0.275 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.530773 0.275 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.530773 0.275 0 0
Integrin signaling R-HSA-354192 0.530773 0.275 0 0
Signaling by NOTCH1 R-HSA-1980143 0.532841 0.273 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.537111 0.270 0 0
Autophagy R-HSA-9612973 0.538106 0.269 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.539433 0.268 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.539433 0.268 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 0.539433 0.268 0 0
Frs2-mediated activation R-HSA-170968 0.539433 0.268 0 0
Chylomicron remodeling R-HSA-8963901 0.539433 0.268 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.539433 0.268 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 0.539433 0.268 0 0
rRNA modification in the mitochondrion R-HSA-6793080 0.539433 0.268 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 0.539433 0.268 0 0
Maturation of nucleoprotein R-HSA-9683610 0.539433 0.268 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.542088 0.266 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.544350 0.264 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.544350 0.264 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.544350 0.264 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.544350 0.264 0 0
Telomere Maintenance R-HSA-157579 0.546413 0.262 0 0
HDACs deacetylate histones R-HSA-3214815 0.547845 0.261 0 0
Glucose metabolism R-HSA-70326 0.550321 0.259 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.554524 0.256 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.554524 0.256 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.554524 0.256 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.557651 0.254 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.557651 0.254 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.557651 0.254 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 0.559976 0.252 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.559976 0.252 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.559976 0.252 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.559976 0.252 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.559976 0.252 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.559976 0.252 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 0.559976 0.252 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 0.559976 0.252 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.559976 0.252 0 0
Physiological factors R-HSA-5578768 0.559976 0.252 0 0
Regulation of KIT signaling R-HSA-1433559 0.559976 0.252 0 0
Non-canonical inflammasome activation R-HSA-9686114 0.559976 0.252 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.559976 0.252 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.564983 0.248 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.564983 0.248 0 0
Regulation of CDH1 Function R-HSA-9764561 0.568866 0.245 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.568866 0.245 0 0
Glycolysis R-HSA-70171 0.570529 0.244 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.570674 0.244 0 0
Oncogene Induced Senescence R-HSA-2559585 0.570674 0.244 0 0
Cellular response to heat stress R-HSA-3371556 0.579412 0.237 0 0
Erythropoietin activates RAS R-HSA-9027284 0.579605 0.237 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.579605 0.237 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.579605 0.237 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.579605 0.237 0 0
G beta:gamma signalling through BTK R-HSA-8964315 0.579605 0.237 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.579605 0.237 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.579605 0.237 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 0.579605 0.237 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.579605 0.237 0 0
Signaling by Activin R-HSA-1502540 0.579605 0.237 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.579605 0.237 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.583415 0.234 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.583415 0.234 0 0
RNA Polymerase III Transcription R-HSA-74158 0.583415 0.234 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.583415 0.234 0 0
Calmodulin induced events R-HSA-111933 0.583415 0.234 0 0
CaM pathway R-HSA-111997 0.583415 0.234 0 0
GPVI-mediated activation cascade R-HSA-114604 0.583415 0.234 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.586232 0.232 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.586535 0.232 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.586535 0.232 0 0
Extension of Telomeres R-HSA-180786 0.589274 0.230 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.595876 0.225 0 0
Degradation of DVL R-HSA-4641258 0.595876 0.225 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.595876 0.225 0 0
Phosphorylation of the APC/C R-HSA-176412 0.598360 0.223 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.598360 0.223 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 0.598360 0.223 0 0
Killing mechanisms R-HSA-9664420 0.598360 0.223 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.598360 0.223 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.598360 0.223 0 0
Phase 4 - resting membrane potential R-HSA-5576886 0.598360 0.223 0 0
Prolonged ERK activation events R-HSA-169893 0.598360 0.223 0 0
Differentiation of T cells R-HSA-9945266 0.598360 0.223 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.598360 0.223 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 0.598360 0.223 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.598360 0.223 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.598360 0.223 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 0.598360 0.223 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.598360 0.223 0 0
Signaling by ERBB2 R-HSA-1227986 0.599242 0.222 0 0
RAB geranylgeranylation R-HSA-8873719 0.599242 0.222 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.599242 0.222 0 0
GABA receptor activation R-HSA-977443 0.599242 0.222 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.599242 0.222 0 0
Ion channel transport R-HSA-983712 0.607019 0.217 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.609051 0.215 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.609051 0.215 0 0
Aquaporin-mediated transport R-HSA-445717 0.609051 0.215 0 0
MAP kinase activation R-HSA-450294 0.609051 0.215 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.612451 0.213 0 0
Cilium Assembly R-HSA-5617833 0.612664 0.213 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.614389 0.212 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.614389 0.212 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.614389 0.212 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.616278 0.210 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.616278 0.210 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.616278 0.210 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.616278 0.210 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.616278 0.210 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.616278 0.210 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.616278 0.210 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.616278 0.210 0 0
Disorders of Developmental Biology R-HSA-9675151 0.616278 0.210 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 0.616278 0.210 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.619953 0.208 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.619953 0.208 0 0
Platelet homeostasis R-HSA-418346 0.624075 0.205 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.628181 0.202 0 0
Signaling by PTK6 R-HSA-8848021 0.628181 0.202 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.631571 0.200 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.631571 0.200 0 0
HIV Transcription Elongation R-HSA-167169 0.631571 0.200 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.631571 0.200 0 0
Aggrephagy R-HSA-9646399 0.631571 0.200 0 0
Generation of second messenger molecules R-HSA-202433 0.631571 0.200 0 0
Attenuation phase R-HSA-3371568 0.631571 0.200 0 0
Interleukin-2 family signaling R-HSA-451927 0.631571 0.200 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.631571 0.200 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.631977 0.199 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.633399 0.198 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.633399 0.198 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 0.633399 0.198 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.633399 0.198 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.633399 0.198 0 0
Choline catabolism R-HSA-6798163 0.633399 0.198 0 0
Membrane Trafficking R-HSA-199991 0.634602 0.197 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.638619 0.195 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.642909 0.192 0 0
Maturation of spike protein R-HSA-9694548 0.642909 0.192 0 0
Potential therapeutics for SARS R-HSA-9679191 0.644211 0.191 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.645759 0.190 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.649756 0.187 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.649756 0.187 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.649756 0.187 0 0
Polo-like kinase mediated events R-HSA-156711 0.649756 0.187 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.649756 0.187 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.649756 0.187 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 0.649756 0.187 0 0
Tie2 Signaling R-HSA-210993 0.649756 0.187 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 0.649756 0.187 0 0
ER-Phagosome pathway R-HSA-1236974 0.652869 0.185 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.653971 0.184 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.653971 0.184 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.653971 0.184 0 0
MAP2K and MAPK activation R-HSA-5674135 0.653971 0.184 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 0.653971 0.184 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.656206 0.183 0 0
DNA Replication R-HSA-69306 0.662111 0.179 0 0
MTOR signalling R-HSA-165159 0.664757 0.177 0 0
Ca-dependent events R-HSA-111996 0.664757 0.177 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.664757 0.177 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.665385 0.177 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.665385 0.177 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.665385 0.177 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.665385 0.177 0 0
Pyrimidine biosynthesis R-HSA-500753 0.665385 0.177 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.665385 0.177 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.665385 0.177 0 0
Maturation of nucleoprotein R-HSA-9694631 0.665385 0.177 0 0
Other interleukin signaling R-HSA-449836 0.665385 0.177 0 0
Co-inhibition by PD-1 R-HSA-389948 0.666726 0.176 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.666726 0.176 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.668224 0.175 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.673420 0.172 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.675270 0.171 0 0
Defective pyroptosis R-HSA-9710421 0.675270 0.171 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.675270 0.171 0 0
TBC/RABGAPs R-HSA-8854214 0.675270 0.171 0 0
Phospholipid metabolism R-HSA-1483257 0.678037 0.169 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.680317 0.167 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.680317 0.167 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.680317 0.167 0 0
Signaling by NODAL R-HSA-1181150 0.680317 0.167 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 0.680317 0.167 0 0
Neutrophil degranulation R-HSA-6798695 0.681347 0.167 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.682048 0.166 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.685090 0.164 0 0
DAP12 interactions R-HSA-2172127 0.685514 0.164 0 0
Amine ligand-binding receptors R-HSA-375280 0.685514 0.164 0 0
Interleukin-17 signaling R-HSA-448424 0.689953 0.161 0 0
Cellular responses to stimuli R-HSA-8953897 0.693075 0.159 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.693206 0.159 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.694583 0.158 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.694583 0.158 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.694583 0.158 0 0
ERK/MAPK targets R-HSA-198753 0.694583 0.158 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 0.694583 0.158 0 0
Basigin interactions R-HSA-210991 0.694583 0.158 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.695491 0.158 0 0
Somitogenesis R-HSA-9824272 0.695491 0.158 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.695491 0.158 0 0
DAG and IP3 signaling R-HSA-1489509 0.695491 0.158 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.695491 0.158 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.698117 0.156 0 0
Hedgehog 'on' state R-HSA-5632684 0.698117 0.156 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.698117 0.156 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.704541 0.152 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.705205 0.152 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.705205 0.152 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.705205 0.152 0 0
Signaling by TGFBR3 R-HSA-9839373 0.705205 0.152 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.706117 0.151 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.708214 0.150 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.708214 0.150 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.708214 0.150 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.708214 0.150 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.708214 0.150 0 0
Assembly Of The HIV Virion R-HSA-175474 0.708214 0.150 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.708214 0.150 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.708214 0.150 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.708214 0.150 0 0
Mitochondrial biogenesis R-HSA-1592230 0.712156 0.147 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.714480 0.146 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.714660 0.146 0 0
Potassium Channels R-HSA-1296071 0.718237 0.144 0 0
FGFR2 alternative splicing R-HSA-6803529 0.721237 0.142 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.721237 0.142 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.721237 0.142 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.721237 0.142 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 0.721237 0.142 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 0.721237 0.142 0 0
Signaling by NOTCH4 R-HSA-9013694 0.721627 0.142 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.724323 0.140 0 0
Mitotic Prophase R-HSA-68875 0.730267 0.137 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.733680 0.134 0 0
Carnitine shuttle R-HSA-200425 0.733680 0.134 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.733680 0.134 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 0.733680 0.134 0 0
Syndecan interactions R-HSA-3000170 0.733680 0.134 0 0
Toll-like Receptor Cascades R-HSA-168898 0.740464 0.130 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.741504 0.130 0 0
Translation of Structural Proteins R-HSA-9694635 0.743687 0.129 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.745568 0.128 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.745568 0.128 0 0
Thromboxane signalling through TP receptor R-HSA-428930 0.745568 0.128 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.745568 0.128 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 0.745568 0.128 0 0
Deadenylation of mRNA R-HSA-429947 0.745568 0.128 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.745568 0.128 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.745568 0.128 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 0.745568 0.128 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 0.745568 0.128 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.745568 0.128 0 0
MHC class II antigen presentation R-HSA-2132295 0.747539 0.126 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.749960 0.125 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.749960 0.125 0 0
The phototransduction cascade R-HSA-2514856 0.749960 0.125 0 0
Interleukin-1 signaling R-HSA-9020702 0.750411 0.125 0 0
PCP/CE pathway R-HSA-4086400 0.750724 0.125 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.756926 0.121 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.756926 0.121 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.756926 0.121 0 0
Formation of the nephric duct R-HSA-9830364 0.756926 0.121 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.758177 0.120 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.764333 0.117 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.764333 0.117 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.764333 0.117 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.766159 0.116 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.766159 0.116 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.767778 0.115 0 0
Metalloprotease DUBs R-HSA-5689901 0.767778 0.115 0 0
Opioid Signalling R-HSA-111885 0.768321 0.114 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.768321 0.114 0 0
Amyloid fiber formation R-HSA-977225 0.770907 0.113 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.770907 0.113 0 0
Translation initiation complex formation R-HSA-72649 0.773911 0.111 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.773911 0.111 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.773911 0.111 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.778146 0.109 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.778146 0.109 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.778146 0.109 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 0.778146 0.109 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.778146 0.109 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.778146 0.109 0 0
Triglyceride biosynthesis R-HSA-75109 0.778146 0.109 0 0
Synthesis of PE R-HSA-1483213 0.778146 0.109 0 0
Signaling by BMP R-HSA-201451 0.778146 0.109 0 0
Insulin processing R-HSA-264876 0.778146 0.109 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.781438 0.107 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.783606 0.106 0 0
HIV elongation arrest and recovery R-HSA-167287 0.788051 0.103 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.788051 0.103 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.788051 0.103 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.788051 0.103 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.788744 0.103 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.788744 0.103 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.789735 0.103 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.790616 0.102 0 0
HIV Infection R-HSA-162906 0.792252 0.101 0 0
Synthesis of PA R-HSA-1483166 0.795834 0.099 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.795914 0.099 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.795914 0.099 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.797515 0.098 0 0
DNA methylation R-HSA-5334118 0.797515 0.098 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.797515 0.098 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.797515 0.098 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.797515 0.098 0 0
mRNA Capping R-HSA-72086 0.797515 0.098 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.797515 0.098 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.797515 0.098 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.802713 0.095 0 0
TCR signaling R-HSA-202403 0.806185 0.094 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.806557 0.093 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.806557 0.093 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.806557 0.093 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.806557 0.093 0 0
Activation of BH3-only proteins R-HSA-114452 0.806557 0.093 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.806557 0.093 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 0.806557 0.093 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.806557 0.093 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.807259 0.093 0 0
Metabolism of non-coding RNA R-HSA-194441 0.809385 0.092 0 0
snRNP Assembly R-HSA-191859 0.809385 0.092 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.809385 0.092 0 0
Triglyceride metabolism R-HSA-8979227 0.809385 0.092 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.815196 0.089 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.815196 0.089 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.815196 0.089 0 0
Downstream signal transduction R-HSA-186763 0.815196 0.089 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.815855 0.088 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.815855 0.088 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.816032 0.088 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.816032 0.088 0 0
PLC beta mediated events R-HSA-112043 0.822128 0.085 0 0
DNA Repair R-HSA-73894 0.822608 0.085 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.823449 0.084 0 0
Inwardly rectifying K+ channels R-HSA-1296065 0.823449 0.084 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.828209 0.082 0 0
Base Excision Repair R-HSA-73884 0.828696 0.082 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.831334 0.080 0 0
Nuclear RNA decay R-HSA-9930044 0.831334 0.080 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.831334 0.080 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.831334 0.080 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.831334 0.080 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.833725 0.079 0 0
PTEN Regulation R-HSA-6807070 0.838186 0.077 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.838627 0.076 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.838868 0.076 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.838868 0.076 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.838868 0.076 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 0.838868 0.076 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.842112 0.075 0 0
Leishmania phagocytosis R-HSA-9664417 0.842112 0.075 0 0
Parasite infection R-HSA-9664407 0.842112 0.075 0 0
L1CAM interactions R-HSA-373760 0.843129 0.074 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.843403 0.074 0 0
Macroautophagy R-HSA-1632852 0.845958 0.073 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.846065 0.073 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.846065 0.073 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.846065 0.073 0 0
Signal amplification R-HSA-392518 0.846065 0.073 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.846065 0.073 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.846065 0.073 0 0
Rab regulation of trafficking R-HSA-9007101 0.847303 0.072 0 0
Neuronal System R-HSA-112316 0.849497 0.071 0 0
Collagen formation R-HSA-1474290 0.852589 0.069 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.852942 0.069 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.852942 0.069 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.852942 0.069 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.852942 0.069 0 0
Regulation of Apoptosis R-HSA-169911 0.852942 0.069 0 0
Signalling to ERKs R-HSA-187687 0.852942 0.069 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.853420 0.069 0 0
G-protein mediated events R-HSA-112040 0.855888 0.068 0 0
Neddylation R-HSA-8951664 0.857793 0.067 0 0
Triglyceride catabolism R-HSA-163560 0.859511 0.066 0 0
HSF1 activation R-HSA-3371511 0.859511 0.066 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.859511 0.066 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.859511 0.066 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.860373 0.065 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.860910 0.065 0 0
Transcription of the HIV genome R-HSA-167172 0.860910 0.065 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.860910 0.065 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.861302 0.065 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.861422 0.065 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.865487 0.063 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.865487 0.063 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.865487 0.063 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.865772 0.063 0 0
Voltage gated Potassium channels R-HSA-1296072 0.865788 0.063 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.865788 0.063 0 0
Degradation of AXIN R-HSA-4641257 0.865788 0.063 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.865788 0.063 0 0
Lysine catabolism R-HSA-71064 0.865788 0.063 0 0
Collagen chain trimerization R-HSA-8948216 0.865788 0.063 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.870478 0.060 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.870478 0.060 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.871784 0.060 0 0
MET promotes cell motility R-HSA-8875878 0.871784 0.060 0 0
Host Interactions of HIV factors R-HSA-162909 0.873966 0.059 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.875031 0.058 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.877513 0.057 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.877513 0.057 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 0.877513 0.057 0 0
RAS processing R-HSA-9648002 0.877513 0.057 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.877513 0.057 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.879437 0.056 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.879437 0.056 0 0
Hedgehog 'off' state R-HSA-5610787 0.881133 0.055 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.882987 0.054 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.882987 0.054 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.882987 0.054 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.882987 0.054 0 0
Diseases of Immune System R-HSA-5260271 0.882987 0.054 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.882987 0.054 0 0
rRNA processing in the mitochondrion R-HSA-8868766 0.882987 0.054 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.882987 0.054 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.883363 0.054 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.888216 0.051 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.888216 0.051 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.888216 0.051 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.888216 0.051 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.888216 0.051 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.888332 0.051 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.891807 0.050 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.893211 0.049 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.893211 0.049 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.893211 0.049 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.893211 0.049 0 0
Translation of Structural Proteins R-HSA-9683701 0.893211 0.049 0 0
Metabolism of RNA R-HSA-8953854 0.894753 0.048 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.895139 0.048 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.897984 0.047 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 0.898401 0.047 0 0
G alpha (q) signalling events R-HSA-416476 0.899753 0.046 0 0
HCMV Late Events R-HSA-9610379 0.900284 0.046 0 0
HIV Life Cycle R-HSA-162587 0.900284 0.046 0 0
Adipogenesis R-HSA-9843745 0.902266 0.045 0 0
Signaling by FGFR4 R-HSA-5654743 0.902543 0.045 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.902543 0.045 0 0
Cellular response to starvation R-HSA-9711097 0.902887 0.044 0 0
Interleukin-10 signaling R-HSA-6783783 0.902990 0.044 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.904652 0.044 0 0
Signaling by NOTCH R-HSA-157118 0.905616 0.043 0 0
Proteasome assembly R-HSA-9907900 0.906900 0.042 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.907736 0.042 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.909726 0.041 0 0
Signaling by FGFR2 R-HSA-5654738 0.909835 0.041 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.910553 0.041 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.910553 0.041 0 0
Signaling by FGFR3 R-HSA-5654741 0.911061 0.040 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.911061 0.040 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.911061 0.040 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.911061 0.040 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.911061 0.040 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.915037 0.039 0 0
Integration of energy metabolism R-HSA-163685 0.917868 0.037 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.918836 0.037 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 0.918836 0.037 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.918836 0.037 0 0
Synthesis of PC R-HSA-1483191 0.918836 0.037 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.919260 0.037 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.919504 0.036 0 0
Hemostasis R-HSA-109582 0.921497 0.036 0 0
Plasma lipoprotein remodeling R-HSA-8963899 0.922464 0.035 0 0
Gluconeogenesis R-HSA-70263 0.922464 0.035 0 0
Metal ion SLC transporters R-HSA-425410 0.922464 0.035 0 0
Signaling by Hedgehog R-HSA-5358351 0.922551 0.035 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.923883 0.034 0 0
HCMV Infection R-HSA-9609646 0.924785 0.034 0 0
DNA Damage Bypass R-HSA-73893 0.925931 0.033 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.926321 0.033 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.927753 0.033 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.927753 0.033 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.930391 0.031 0 0
Leishmania infection R-HSA-9658195 0.930732 0.031 0 0
Parasitic Infection Pathways R-HSA-9824443 0.930732 0.031 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.930982 0.031 0 0
Complex IV assembly R-HSA-9864848 0.932407 0.030 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.932407 0.030 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.932938 0.030 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.933210 0.030 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.933227 0.030 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.934513 0.029 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.935371 0.029 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.935371 0.029 0 0
Peptide chain elongation R-HSA-156902 0.935397 0.029 0 0
Selective autophagy R-HSA-9663891 0.935397 0.029 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.935430 0.029 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.935430 0.029 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.935430 0.029 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.937112 0.028 0 0
Peptide hormone metabolism R-HSA-2980736 0.937468 0.028 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.938318 0.028 0 0
Nucleotide biosynthesis R-HSA-8956320 0.938318 0.028 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.938546 0.028 0 0
Neurotransmitter release cycle R-HSA-112310 0.940061 0.027 0 0
Downstream TCR signaling R-HSA-202424 0.940061 0.027 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.940570 0.027 0 0
rRNA processing R-HSA-72312 0.940698 0.027 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.942271 0.026 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.942554 0.026 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.943712 0.025 0 0
G alpha (z) signalling events R-HSA-418597 0.943712 0.025 0 0
Signaling by NOTCH3 R-HSA-9012852 0.943712 0.025 0 0
Vesicle-mediated transport R-HSA-5653656 0.944335 0.025 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.945241 0.024 0 0
Signaling by FGFR1 R-HSA-5654736 0.946230 0.024 0 0
Metabolism of amine-derived hormones R-HSA-209776 0.946230 0.024 0 0
Signaling by EGFR R-HSA-177929 0.946230 0.024 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.946461 0.024 0 0
Protein folding R-HSA-391251 0.946461 0.024 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.948504 0.023 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.950933 0.022 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.950933 0.022 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.952207 0.021 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.952901 0.021 0 0
Regulation of beta-cell development R-HSA-186712 0.953128 0.021 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.953128 0.021 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.953988 0.020 0 0
Eukaryotic Translation Termination R-HSA-72764 0.953988 0.020 0 0
Metabolism of polyamines R-HSA-351202 0.955225 0.020 0 0
Platelet degranulation R-HSA-114608 0.956723 0.019 0 0
Collagen degradation R-HSA-1442490 0.957229 0.019 0 0
Signaling by FGFR R-HSA-190236 0.958958 0.018 0 0
Mitochondrial protein import R-HSA-1268020 0.959143 0.018 0 0
Signaling by PDGF R-HSA-186797 0.959143 0.018 0 0
Immune System R-HSA-168256 0.960738 0.017 0 0
CD22 mediated BCR regulation R-HSA-5690714 0.962718 0.017 0 0
Ion transport by P-type ATPases R-HSA-936837 0.962718 0.017 0 0
Selenocysteine synthesis R-HSA-2408557 0.963411 0.016 0 0
SARS-CoV Infections R-HSA-9679506 0.965325 0.015 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.965980 0.015 0 0
Viral mRNA Translation R-HSA-192823 0.966118 0.015 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.967398 0.014 0 0
Kidney development R-HSA-9830369 0.967503 0.014 0 0
Nicotinate metabolism R-HSA-196807 0.967503 0.014 0 0
HCMV Early Events R-HSA-9609690 0.967553 0.014 0 0
GPCR downstream signalling R-HSA-388396 0.971324 0.013 0 0
COPII-mediated vesicle transport R-HSA-204005 0.971675 0.012 0 0
Ribosome-associated quality control R-HSA-9948299 0.972304 0.012 0 0
ECM proteoglycans R-HSA-3000178 0.972943 0.012 0 0
Retinoid metabolism and transport R-HSA-975634 0.972943 0.012 0 0
Metabolism of cofactors R-HSA-8978934 0.972943 0.012 0 0
Developmental Cell Lineages R-HSA-9734767 0.973515 0.012 0 0
G alpha (s) signalling events R-HSA-418555 0.973690 0.012 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.973690 0.012 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.974154 0.011 0 0
Cellular response to chemical stress R-HSA-9711123 0.976877 0.010 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.977005 0.010 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 0.977473 0.010 0 0
Protein ubiquitination R-HSA-8852135 0.977473 0.010 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.977473 0.010 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.978482 0.009 0 0
UCH proteinases R-HSA-5689603 0.978482 0.009 0 0
RNA Polymerase I Transcription R-HSA-73864 0.980367 0.009 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.980367 0.009 0 0
ABC transporter disorders R-HSA-5619084 0.980367 0.009 0 0
Cholesterol biosynthesis R-HSA-191273 0.980367 0.009 0 0
Integrin cell surface interactions R-HSA-216083 0.980367 0.009 0 0
Visual phototransduction R-HSA-2187338 0.980499 0.009 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.981093 0.008 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.981246 0.008 0 0
Signaling by MET R-HSA-6806834 0.982086 0.008 0 0
PKR-mediated signaling R-HSA-9833482 0.982086 0.008 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.982889 0.007 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.983672 0.007 0 0
Protein localization R-HSA-9609507 0.984244 0.007 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.984797 0.007 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.985087 0.007 0 0
PPARA activates gene expression R-HSA-1989781 0.985332 0.006 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.986348 0.006 0 0
Innate Immune System R-HSA-168249 0.986493 0.006 0 0
Formation of the cornified envelope R-HSA-6809371 0.986745 0.006 0 0
Post NMDA receptor activation events R-HSA-438064 0.987586 0.005 0 0
Pyruvate metabolism R-HSA-70268 0.987586 0.005 0 0
Transmission across Chemical Synapses R-HSA-112315 0.988238 0.005 0 0
Signaling by GPCR R-HSA-372790 0.989535 0.005 0 0
SLC transporter disorders R-HSA-5619102 0.990492 0.004 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.990552 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.990572 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 0.991399 0.004 0 0
Mitochondrial translation elongation R-HSA-5389840 0.992505 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.992505 0.003 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.993008 0.003 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.993162 0.003 0 0
Mitochondrial translation initiation R-HSA-5368286 0.993162 0.003 0 0
Regulation of insulin secretion R-HSA-422356 0.993162 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 0.993762 0.003 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.994309 0.002 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.994564 0.002 0 0
RSV-host interactions R-HSA-9833110 0.995041 0.002 0 0
Nucleotide Excision Repair R-HSA-5696398 0.995264 0.002 0 0
Gene Silencing by RNA R-HSA-211000 0.995679 0.002 0 0
Mitochondrial translation termination R-HSA-5419276 0.996059 0.002 0 0
Extracellular matrix organization R-HSA-1474244 0.996272 0.002 0 0
Inositol phosphate metabolism R-HSA-1483249 0.996566 0.001 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.996767 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.997008 0.001 0 0
Metabolism of nucleotides R-HSA-15869 0.997197 0.001 0 0
Interferon gamma signaling R-HSA-877300 0.997255 0.001 0 0
Sphingolipid metabolism R-HSA-428157 0.997414 0.001 0 0
Selenoamino acid metabolism R-HSA-2408522 0.997765 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.997928 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.998107 0.001 0 0
Viral Infection Pathways R-HSA-9824446 0.998744 0.001 0 0
Sensory perception of taste R-HSA-9717189 0.998807 0.001 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 0.998807 0.001 0 0
Post-translational protein modification R-HSA-597592 0.998844 0.001 0 0
Influenza Infection R-HSA-168255 0.998846 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.998861 0.000 0 0
G alpha (i) signalling events R-HSA-418594 0.999034 0.000 0 0
Mitochondrial translation R-HSA-5368287 0.999174 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999536 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 0.999557 0.000 0 0
Keratinization R-HSA-6805567 0.999643 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 0.999671 0.000 0 0
tRNA processing R-HSA-72306 0.999828 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 0.999836 0.000 0 0
Translation R-HSA-72766 0.999848 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 0.999865 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999871 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999881 0.000 0 0
Disease R-HSA-1643685 0.999881 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999904 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 0.999918 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.999947 0.000 0 0
Interferon Signaling R-HSA-913531 0.999948 0.000 0 0
Transport of small molecules R-HSA-382551 0.999948 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 0.999965 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 0.999977 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.999984 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 0.999991 0.000 0 0
Infectious disease R-HSA-5663205 0.999996 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 0.999999 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 0.999999 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 0.000 0 0
Biological oxidations R-HSA-211859 1.000000 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.000005 5.327 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.000011 4.975 0 0
Cell Cycle, Mitotic R-HSA-69278 0.000013 4.883 0 0
Apoptotic execution phase R-HSA-75153 0.000009 5.030 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.000023 4.645 0 0
Cell Cycle R-HSA-1640170 0.000024 4.621 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.000035 4.462 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.000032 4.491 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.000032 4.491 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.000109 3.962 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.000120 3.919 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.000169 3.772 0 0
Axon guidance R-HSA-422475 0.000224 3.650 0 0
Signaling by ROBO receptors R-HSA-376176 0.000203 3.694 0 0
Peptide chain elongation R-HSA-156902 0.000284 3.546 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.000287 3.542 0 0
Signaling by ALK in cancer R-HSA-9700206 0.000287 3.542 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.000328 3.484 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.000328 3.484 0 0
Nervous system development R-HSA-9675108 0.000304 3.517 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.000389 3.410 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.000431 3.366 0 0
Selenocysteine synthesis R-HSA-2408557 0.000427 3.369 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.000476 3.323 0 0
Influenza Infection R-HSA-168255 0.000513 3.290 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.000637 3.196 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.000663 3.179 0 0
Eukaryotic Translation Termination R-HSA-72764 0.000700 3.155 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.000693 3.159 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.000724 3.140 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.000806 3.094 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.000954 3.020 0 0
Metabolism of RNA R-HSA-8953854 0.001143 2.942 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.001121 2.950 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.001217 2.915 0 0
Specification of primordial germ cells R-HSA-9827857 0.001281 2.892 0 0
Striated Muscle Contraction R-HSA-390522 0.001543 2.812 0 0
Viral mRNA Translation R-HSA-192823 0.001424 2.847 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.001554 2.809 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.001524 2.817 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.001600 2.796 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.001547 2.810 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.001711 2.767 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.002145 2.669 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.002081 2.682 0 0
M Phase R-HSA-68886 0.002062 2.686 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.002036 2.691 0 0
Interleukin-12 signaling R-HSA-9020591 0.002130 2.672 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.002158 2.666 0 0
Interleukin-12 family signaling R-HSA-447115 0.002251 2.648 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.002417 2.617 0 0
DNA Double Strand Break Response R-HSA-5693606 0.002628 2.580 0 0
G alpha (12/13) signalling events R-HSA-416482 0.002572 2.590 0 0
rRNA processing R-HSA-72312 0.002579 2.589 0 0
Mitotic Prophase R-HSA-68875 0.002630 2.580 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.002892 2.539 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.003124 2.505 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.003124 2.505 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.003570 2.447 0 0
Regulation of TP53 Activity R-HSA-5633007 0.003761 2.425 0 0
ALK mutants bind TKIs R-HSA-9700645 0.004094 2.388 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.004094 2.388 0 0
Apoptosis R-HSA-109581 0.004225 2.374 1 0
Ribosome-associated quality control R-HSA-9948299 0.004568 2.340 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.004621 2.335 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.004857 2.314 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.004941 2.306 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.005099 2.292 0 0
Semaphorin interactions R-HSA-373755 0.005301 2.276 0 0
Neurexins and neuroligins R-HSA-6794361 0.005380 2.269 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.005808 2.236 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.006069 2.217 0 0
NRAGE signals death through JNK R-HSA-193648 0.008015 2.096 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.008342 2.079 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 0.008835 2.054 0 0
Mitotic Anaphase R-HSA-68882 0.008921 2.050 0 0
mRNA Splicing R-HSA-72172 0.009857 2.006 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.009331 2.030 0 0
Manipulation of host energy metabolism R-HSA-9636667 0.011355 1.945 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 0.011355 1.945 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.011355 1.945 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.012373 1.908 0 0
Death Receptor Signaling R-HSA-73887 0.011938 1.923 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 0.013429 1.872 0 0
Cell Cycle Checkpoints R-HSA-69620 0.015273 1.816 0 0
mRNA 3'-end processing R-HSA-72187 0.016042 1.795 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.016123 1.793 0 0
Notch-HLH transcription pathway R-HSA-350054 0.017696 1.752 0 0
Translation initiation complex formation R-HSA-72649 0.019071 1.720 0 0
Programmed Cell Death R-HSA-5357801 0.019238 1.716 1 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.019314 1.714 0 0
Regulation of TP53 Expression R-HSA-6804754 0.019498 1.710 0 0
Signaling by SCF-KIT R-HSA-1433557 0.020436 1.690 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.021520 1.667 0 0
Cellular responses to stimuli R-HSA-8953897 0.021524 1.667 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.022487 1.648 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.023804 1.623 0 0
Cellular responses to stress R-HSA-2262752 0.024953 1.603 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.026314 1.580 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.026728 1.573 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.026730 1.573 0 0
Cellular response to starvation R-HSA-9711097 0.028275 1.549 0 0
MET activates STAT3 R-HSA-8875791 0.029432 1.531 0 0
Axonal growth stimulation R-HSA-209563 0.029432 1.531 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.030969 1.509 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.029159 1.535 0 0
RET signaling R-HSA-8853659 0.028606 1.544 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.028833 1.540 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.030969 1.509 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.031456 1.502 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.031586 1.501 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.031653 1.500 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.032614 1.487 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.032868 1.483 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.037696 1.424 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.037696 1.424 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.034574 1.461 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.034485 1.462 0 0
Selenoamino acid metabolism R-HSA-2408522 0.036491 1.438 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.037807 1.422 0 0
Cellular Senescence R-HSA-2559583 0.039815 1.400 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.040951 1.388 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.041091 1.386 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.041091 1.386 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.042500 1.372 0 0
IRE1alpha activates chaperones R-HSA-381070 0.045833 1.339 0 0
Protein folding R-HSA-391251 0.048350 1.316 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.046902 1.329 0 0
Integration of provirus R-HSA-162592 0.046565 1.332 0 0
Smooth Muscle Contraction R-HSA-445355 0.046218 1.335 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.051050 1.292 0 0
Basigin interactions R-HSA-210991 0.051050 1.292 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.051595 1.287 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 0.051595 1.287 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 0.051595 1.287 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.057040 1.244 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.058568 1.232 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.057040 1.244 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.057040 1.244 0 0
Integrin signaling R-HSA-354192 0.058568 1.232 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.058568 1.232 0 0
Interleukin-15 signaling R-HSA-8983432 0.054412 1.264 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.052260 1.282 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.057040 1.244 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.054412 1.264 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.054412 1.264 0 0
Signaling by EGFR R-HSA-177929 0.056783 1.246 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.061198 1.213 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.062846 1.202 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.063389 1.198 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.063389 1.198 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.063777 1.195 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.065448 1.184 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.066182 1.179 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.066182 1.179 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.067997 1.168 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.071845 1.144 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.070093 1.154 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.075202 1.124 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.069239 1.160 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.067997 1.168 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.076333 1.117 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.077145 1.113 0 0
Regulation of KIT signaling R-HSA-1433559 0.071845 1.144 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.077145 1.113 0 0
Neurodegenerative Diseases R-HSA-8863678 0.077145 1.113 0 0
Muscle contraction R-HSA-397014 0.073266 1.135 0 0
DCC mediated attractive signaling R-HSA-418885 0.081385 1.089 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.081385 1.089 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.091437 1.039 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.084538 1.073 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.084538 1.073 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.080909 1.092 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.080909 1.092 0 0
RNA Polymerase III Transcription R-HSA-74158 0.080909 1.092 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.085525 1.068 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.085525 1.068 0 0
HIV Life Cycle R-HSA-162587 0.087124 1.060 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.085525 1.068 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.087113 1.060 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.091437 1.039 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.087113 1.060 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.081385 1.089 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.093557 1.029 0 0
FLT3 signaling in disease R-HSA-9682385 0.080909 1.092 0 0
Chromatin organization R-HSA-4839726 0.085368 1.069 0 0
Chromatin modifying enzymes R-HSA-3247509 0.087800 1.057 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.083192 1.080 0 0
Sensory processing of sound R-HSA-9659379 0.095227 1.021 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 0.100530 0.998 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 0.100530 0.998 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 0.146943 0.833 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 0.146943 0.833 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 0.146943 0.833 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 0.146943 0.833 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 0.190964 0.719 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 0.190964 0.719 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.099300 1.003 0 0
Netrin mediated repulsion signals R-HSA-418886 0.099300 1.003 0 0
MET interacts with TNS proteins R-HSA-8875513 0.232716 0.633 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.232716 0.633 0 0
Defective ABCD4 causes MAHCJ R-HSA-5683329 0.232716 0.633 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.232716 0.633 0 0
MET activates PTPN11 R-HSA-8865999 0.232716 0.633 0 0
Signalling to STAT3 R-HSA-198745 0.232716 0.633 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.232716 0.633 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 0.272316 0.565 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.272316 0.565 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.272316 0.565 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.272316 0.565 0 0
Binding and entry of HIV virion R-HSA-173107 0.151819 0.819 0 0
Folding of actin by CCT/TriC R-HSA-390450 0.151819 0.819 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.101976 0.992 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.101976 0.992 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.170347 0.769 0 0
Signaling by APC mutants R-HSA-4839744 0.170347 0.769 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.170347 0.769 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.170347 0.769 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.170347 0.769 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 0.309874 0.509 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.309874 0.509 0 0
Defective F9 activation R-HSA-9673221 0.309874 0.509 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 0.309874 0.509 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 0.309874 0.509 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.112971 0.947 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 0.189224 0.723 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 0.189224 0.723 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.189224 0.723 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.124392 0.905 0 0
MET activates RAS signaling R-HSA-8851805 0.208363 0.681 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.208363 0.681 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.208363 0.681 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.208363 0.681 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.208363 0.681 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.208363 0.681 0 0
Plus-strand DNA synthesis R-HSA-164525 0.345496 0.462 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.345496 0.462 0 0
Cam-PDE 1 activation R-HSA-111957 0.345496 0.462 0 0
Phosphorylation of Emi1 R-HSA-176417 0.345496 0.462 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.345496 0.462 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.345496 0.462 0 0
Signaling by MAPK mutants R-HSA-9652817 0.345496 0.462 0 0
Negative regulation of MET activity R-HSA-6807004 0.148394 0.829 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.148394 0.829 0 0
Formation of axial mesoderm R-HSA-9796292 0.227687 0.643 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.227687 0.643 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.227687 0.643 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.126282 0.899 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.379281 0.421 0 0
STAT5 Activation R-HSA-9645135 0.379281 0.421 0 0
Uncoating of the HIV Virion R-HSA-162585 0.379281 0.421 0 0
Autointegration results in viral DNA circles R-HSA-177539 0.379281 0.421 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 0.379281 0.421 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.379281 0.421 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.135510 0.868 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.135510 0.868 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.135510 0.868 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.266618 0.574 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.266618 0.574 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.266618 0.574 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.266618 0.574 0 0
G beta:gamma signalling through BTK R-HSA-8964315 0.266618 0.574 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.114292 0.942 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.154746 0.810 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.164727 0.783 0 0
Deadenylation of mRNA R-HSA-429947 0.213741 0.670 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 0.213741 0.670 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.411324 0.386 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.411324 0.386 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 0.411324 0.386 0 0
SOS-mediated signalling R-HSA-112412 0.411324 0.386 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.411324 0.386 0 0
RAF activation R-HSA-5673000 0.174932 0.757 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.096803 1.014 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.185345 0.732 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.305536 0.515 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.305536 0.515 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.305536 0.515 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.153185 0.815 0 0
Nucleosome assembly R-HSA-774815 0.153185 0.815 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.324864 0.488 0 0
Reverse Transcription of HIV RNA R-HSA-162589 0.441715 0.355 0 0
Minus-strand DNA synthesis R-HSA-164516 0.441715 0.355 0 0
Type I hemidesmosome assembly R-HSA-446107 0.441715 0.355 0 0
MET receptor recycling R-HSA-8875656 0.441715 0.355 0 0
Activation of RAS in B cells R-HSA-1169092 0.441715 0.355 0 0
Formation of annular gap junctions R-HSA-196025 0.441715 0.355 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.441715 0.355 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.441715 0.355 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.269599 0.569 0 0
Degradation of CDH1 R-HSA-9766229 0.187708 0.727 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.283836 0.547 0 0
Activation of the pre-replicative complex R-HSA-68962 0.298134 0.526 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.363054 0.440 0 0
Gap junction degradation R-HSA-190873 0.470539 0.327 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.175626 0.755 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.202096 0.694 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.381846 0.418 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.381846 0.418 0 0
HDACs deacetylate histones R-HSA-3214815 0.243977 0.613 0 0
Regulation of CDH1 Function R-HSA-9764561 0.263655 0.579 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.400397 0.398 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.497876 0.303 0 0
Metabolism of non-coding RNA R-HSA-194441 0.283676 0.547 0 0
snRNP Assembly R-HSA-191859 0.283676 0.547 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.321487 0.493 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.418682 0.378 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.418682 0.378 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.242131 0.616 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.257905 0.589 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.548393 0.261 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.404530 0.393 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.404530 0.393 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.453716 0.343 0 0
MET activates PTK2 signaling R-HSA-8874081 0.505443 0.296 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.571715 0.243 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.571715 0.243 0 0
Scavenging by Class F Receptors R-HSA-3000484 0.571715 0.243 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.427904 0.369 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.480694 0.318 0 0
HIV Transcription Initiation R-HSA-167161 0.480694 0.318 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.480694 0.318 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.521765 0.283 0 0
Centrosome maturation R-HSA-380287 0.448367 0.348 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.485492 0.314 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.507027 0.295 0 0
DNA methylation R-HSA-5334118 0.553307 0.257 0 0
Late endosomal microautophagy R-HSA-9615710 0.553307 0.257 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.532646 0.274 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.557498 0.254 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.551147 0.259 0 0
PPARA activates gene expression R-HSA-1989781 0.566572 0.247 0 0
Signaling by MET R-HSA-6806834 0.324715 0.488 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.463293 0.334 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.407295 0.390 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.407295 0.390 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.463293 0.334 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.463293 0.334 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.333938 0.476 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.391404 0.407 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.136150 0.866 0 0
Ephrin signaling R-HSA-3928664 0.344049 0.463 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.341173 0.467 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 0.369783 0.432 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.459430 0.338 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.369783 0.432 0 0
Separation of Sister Chromatids R-HSA-2467813 0.174502 0.758 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.306801 0.513 0 0
G-protein beta:gamma signalling R-HSA-397795 0.341173 0.467 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.361769 0.442 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.124392 0.905 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.247127 0.607 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.262908 0.580 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.244043 0.613 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.321487 0.493 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.321487 0.493 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.321487 0.493 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.568517 0.245 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.124392 0.905 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.200180 0.699 0 0
MAP2K and MAPK activation R-HSA-5674135 0.262908 0.580 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.186836 0.729 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.131288 0.882 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.170347 0.769 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.411324 0.386 0 0
Stabilization of p53 R-HSA-69541 0.440009 0.357 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.521765 0.283 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.134558 0.871 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.436678 0.360 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.125184 0.902 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.189224 0.723 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.126282 0.899 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.147106 0.832 0 0
Homology Directed Repair R-HSA-5693538 0.400124 0.398 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 0.133731 0.874 0 0
Regulation of gap junction activity R-HSA-191650 0.272316 0.565 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.173737 0.760 0 0
Passive transport by Aquaporins R-HSA-432047 0.305536 0.515 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.240057 0.620 0 0
Budding and maturation of HIV virion R-HSA-162588 0.312471 0.505 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.454368 0.343 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.553307 0.257 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.537465 0.270 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.233093 0.632 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.352707 0.453 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.417008 0.380 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.417008 0.380 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.571715 0.243 0 0
Repression of WNT target genes R-HSA-4641265 0.571715 0.243 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.440009 0.357 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.507838 0.294 0 0
DNA Replication R-HSA-69306 0.552721 0.257 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 0.568517 0.245 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.211134 0.675 0 0
FOXO-mediated transcription R-HSA-9614085 0.365815 0.437 0 0
Netrin-1 signaling R-HSA-373752 0.297873 0.526 0 0
PTK6 Activates STAT3 R-HSA-8849474 0.309874 0.509 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.160913 0.793 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.112890 0.947 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.206744 0.685 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.298134 0.526 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 0.470539 0.327 0 0
Signaling by RAS mutants R-HSA-6802949 0.321487 0.493 0 0
Tight junction interactions R-HSA-420029 0.488762 0.311 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.453716 0.343 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.185345 0.732 0 0
G1 Phase R-HSA-69236 0.297873 0.526 0 0
Cyclin D associated events in G1 R-HSA-69231 0.297873 0.526 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.438157 0.358 0 0
DAP12 signaling R-HSA-2424491 0.568517 0.245 0 0
HIV Infection R-HSA-162906 0.332734 0.478 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.133731 0.874 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.178824 0.748 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.178315 0.749 0 0
Inhibition of nitric oxide production R-HSA-9636249 0.232716 0.633 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.309874 0.509 0 0
MET Receptor Activation R-HSA-6806942 0.379281 0.421 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.251427 0.600 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.427904 0.369 0 0
Proteasome assembly R-HSA-9907900 0.519929 0.284 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.481163 0.318 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.417614 0.379 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.114292 0.942 0 0
Myogenesis R-HSA-525793 0.241401 0.617 0 0
Signal attenuation R-HSA-74749 0.497876 0.303 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.293794 0.532 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.293794 0.532 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.293794 0.532 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.293794 0.532 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.471734 0.326 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.298134 0.526 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.295902 0.529 0 0
Adipogenesis R-HSA-9843745 0.377585 0.423 0 0
EPH-Ephrin signaling R-HSA-2682334 0.096931 1.014 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.121653 0.915 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.221503 0.655 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.553307 0.257 0 0
Translation R-HSA-72766 0.354165 0.451 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 0.146943 0.833 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.190964 0.719 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.116187 0.935 0 0
Regulation of CDH11 function R-HSA-9762292 0.151819 0.819 0 0
Reelin signalling pathway R-HSA-8866376 0.309874 0.509 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.189224 0.723 0 0
Signaling by AXIN mutants R-HSA-4839735 0.189224 0.723 0 0
Pentose phosphate pathway disease R-HSA-6791465 0.345496 0.462 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.345496 0.462 0 0
Synthesis of PS R-HSA-1483101 0.345496 0.462 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.227687 0.643 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.213741 0.670 0 0
Interleukin-23 signaling R-HSA-9020933 0.441715 0.355 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.344049 0.463 0 0
Unwinding of DNA R-HSA-176974 0.470539 0.327 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.309658 0.509 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.303973 0.517 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.436678 0.360 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.523803 0.281 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.253573 0.596 0 0
Orc1 removal from chromatin R-HSA-68949 0.392718 0.406 0 0
Activation of RAC1 R-HSA-428540 0.548393 0.261 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.548393 0.261 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 0.571715 0.243 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.474167 0.324 0 0
Recycling pathway of L1 R-HSA-437239 0.557498 0.254 0 0
Gene expression (Transcription) R-HSA-74160 0.147225 0.832 0 0
S Phase R-HSA-69242 0.385233 0.414 0 0
G2/M Transition R-HSA-69275 0.134498 0.871 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.262908 0.580 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.341173 0.467 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.142012 0.848 0 0
RNA Polymerase II Transcription R-HSA-73857 0.379115 0.421 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.427904 0.369 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.252726 0.597 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.363054 0.440 0 0
Platelet degranulation R-HSA-114608 0.138703 0.858 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.570605 0.244 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.161648 0.791 0 0
ESR-mediated signaling R-HSA-8939211 0.210046 0.678 0 0
DNA Repair R-HSA-73894 0.452514 0.344 0 0
Mitotic Prometaphase R-HSA-68877 0.103941 0.983 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.107152 0.970 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.248853 0.604 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.151819 0.819 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 0.101976 0.992 0 0
Neurofascin interactions R-HSA-447043 0.379281 0.421 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.266618 0.574 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.266618 0.574 0 0
Long-term potentiation R-HSA-9620244 0.227490 0.643 0 0
Rap1 signalling R-HSA-392517 0.363054 0.440 0 0
TBC/RABGAPs R-HSA-8854214 0.286144 0.543 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.148943 0.827 0 0
G2/M Checkpoints R-HSA-69481 0.225356 0.647 0 0
Cellular response to heat stress R-HSA-3371556 0.423890 0.373 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.439697 0.357 0 0
EGFR downregulation R-HSA-182971 0.312471 0.505 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.099300 1.003 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.133731 0.874 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 0.272316 0.565 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 0.345496 0.462 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.164727 0.783 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 0.286105 0.543 0 0
Interleukin-21 signaling R-HSA-9020958 0.470539 0.327 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.326824 0.486 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.326824 0.486 0 0
Signalling to RAS R-HSA-167044 0.400397 0.398 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.436678 0.360 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.417614 0.379 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.505443 0.296 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.571715 0.243 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.521765 0.283 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.502124 0.299 0 0
FLT3 Signaling R-HSA-9607240 0.114292 0.942 0 0
Signaling by VEGF R-HSA-194138 0.326183 0.487 0 0
MAPK family signaling cascades R-HSA-5683057 0.308275 0.511 0 0
Interleukin-9 signaling R-HSA-8985947 0.441715 0.355 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.382868 0.417 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.519929 0.284 0 0
Signaling by ALK R-HSA-201556 0.100238 0.999 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.228908 0.640 0 0
Downstream signal transduction R-HSA-186763 0.135510 0.868 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.227490 0.643 0 0
Oncogene Induced Senescence R-HSA-2559585 0.384008 0.416 0 0
Reproduction R-HSA-1474165 0.250258 0.602 0 0
G1/S Transition R-HSA-69206 0.463293 0.334 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.172666 0.763 0 0
HDMs demethylate histones R-HSA-3214842 0.227490 0.643 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.226680 0.645 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.101568 0.993 0 0
Signaling by KIT in disease R-HSA-9669938 0.186836 0.729 0 0
Interleukin-2 family signaling R-HSA-451927 0.240057 0.620 0 0
DSCAM interactions R-HSA-376172 0.190964 0.719 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 0.379281 0.421 0 0
Lactose synthesis R-HSA-5653890 0.379281 0.421 0 0
VLDL clearance R-HSA-8964046 0.411324 0.386 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 0.411324 0.386 0 0
Ca2+ activated K+ channels R-HSA-1296052 0.411324 0.386 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.174932 0.757 0 0
Disorders of Developmental Biology R-HSA-9675151 0.305536 0.515 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.441715 0.355 0 0
SLC-mediated bile acid transport R-HSA-9958517 0.441715 0.355 0 0
Calcineurin activates NFAT R-HSA-2025928 0.470539 0.327 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.234290 0.630 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.400397 0.398 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.497876 0.303 0 0
2-LTR circle formation R-HSA-164843 0.497876 0.303 0 0
Signaling by NOTCH1 R-HSA-1980143 0.288241 0.540 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.471734 0.326 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.548393 0.261 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.548393 0.261 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.548393 0.261 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.440009 0.357 0 0
Deubiquitination R-HSA-5688426 0.387282 0.412 0 0
Activation of BH3-only proteins R-HSA-114452 0.298134 0.526 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.418682 0.378 0 0
MTOR signalling R-HSA-165159 0.493946 0.306 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.253573 0.596 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.184332 0.734 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.293794 0.532 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.507838 0.294 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.237788 0.624 0 0
Signaling by Hippo R-HSA-2028269 0.112971 0.947 0 0
Developmental Biology R-HSA-1266738 0.193208 0.714 0 0
Diseases of programmed cell death R-HSA-9645723 0.257905 0.589 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.314203 0.503 0 0
Ion transport by P-type ATPases R-HSA-936837 0.529737 0.276 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.556493 0.255 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.269599 0.569 0 0
Hemostasis R-HSA-109582 0.499473 0.301 0 0
PECAM1 interactions R-HSA-210990 0.170347 0.769 0 0
Nuclear import of Rev protein R-HSA-180746 0.174932 0.757 0 0
Kinesins R-HSA-983189 0.155757 0.808 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.167880 0.775 0 0
tRNA processing in the nucleus R-HSA-6784531 0.314203 0.503 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.571715 0.243 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.521765 0.283 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.553307 0.257 0 0
Signaling by PTK6 R-HSA-8848021 0.178315 0.749 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.178315 0.749 0 0
Protein ubiquitination R-HSA-8852135 0.448367 0.348 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.234299 0.630 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.525012 0.280 0 0
Signal Transduction R-HSA-162582 0.393696 0.405 0 0
Nuclear RNA decay R-HSA-9930044 0.341173 0.467 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.453716 0.343 0 0
Signaling by Leptin R-HSA-2586552 0.497876 0.303 0 0
Host Interactions of HIV factors R-HSA-162909 0.311733 0.506 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.498587 0.302 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.154746 0.810 0 0
Post NMDA receptor activation events R-HSA-438064 0.249980 0.602 0 0
Cell-Cell communication R-HSA-1500931 0.513183 0.290 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.272316 0.565 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.309874 0.509 0 0
NrCAM interactions R-HSA-447038 0.309874 0.509 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.189224 0.723 0 0
Relaxin receptors R-HSA-444821 0.345496 0.462 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 0.345496 0.462 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.148394 0.829 0 0
Negative regulation of FLT3 R-HSA-9706369 0.286105 0.543 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.127816 0.893 0 0
RUNX2 regulates bone development R-HSA-8941326 0.195955 0.708 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.441715 0.355 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.470539 0.327 0 0
Interleukin-27 signaling R-HSA-9020956 0.497876 0.303 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 0.497876 0.303 0 0
Bicarbonate transporters R-HSA-425381 0.523803 0.281 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.505443 0.296 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.571715 0.243 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.571715 0.243 0 0
Leading Strand Synthesis R-HSA-69109 0.571715 0.243 0 0
Polymerase switching R-HSA-69091 0.571715 0.243 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 0.571715 0.243 0 0
Regulation of IFNG signaling R-HSA-877312 0.571715 0.243 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.571715 0.243 0 0
Signaling by FGFR in disease R-HSA-1226099 0.438157 0.358 0 0
Signaling by ERBB2 R-HSA-1227986 0.155757 0.808 0 0
Other interleukin signaling R-HSA-449836 0.363054 0.440 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.400397 0.398 0 0
Suppression of phagosomal maturation R-HSA-9637687 0.505443 0.296 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.137015 0.863 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.467281 0.330 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.352471 0.453 0 0
The NLRP3 inflammasome R-HSA-844456 0.363054 0.440 0 0
Glycolysis R-HSA-70171 0.374336 0.427 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.532646 0.274 0 0
Tie2 Signaling R-HSA-210993 0.344049 0.463 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.341173 0.467 0 0
Co-stimulation by CD28 R-HSA-389356 0.345228 0.462 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.505443 0.296 0 0
TNF signaling R-HSA-75893 0.253769 0.596 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 0.190964 0.719 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 0.309874 0.509 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 0.345496 0.462 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.345496 0.462 0 0
Signal regulatory protein family interactions R-HSA-391160 0.247127 0.607 0 0
CHL1 interactions R-HSA-447041 0.411324 0.386 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.441715 0.355 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 0.441715 0.355 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 0.441715 0.355 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 0.470539 0.327 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 0.470539 0.327 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.341173 0.467 0 0
PI3K/AKT activation R-HSA-198203 0.497876 0.303 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.321487 0.493 0 0
DS-GAG biosynthesis R-HSA-2022923 0.548393 0.261 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.571715 0.243 0 0
Disorders of Nervous System Development R-HSA-9697154 0.571715 0.243 0 0
Pervasive developmental disorders R-HSA-9005895 0.571715 0.243 0 0
Glucose metabolism R-HSA-70326 0.541777 0.266 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.161554 0.792 0 0
Signaling by NOTCH R-HSA-157118 0.511943 0.291 0 0
Signaling by PDGF R-HSA-186797 0.507838 0.294 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.155426 0.808 0 0
Assembly Of The HIV Virion R-HSA-175474 0.418682 0.378 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.521765 0.283 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.408049 0.389 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.274485 0.561 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.251427 0.600 0 0
RMTs methylate histone arginines R-HSA-3214858 0.297873 0.526 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.315617 0.501 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.500003 0.301 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.338222 0.471 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.553307 0.257 0 0
Gluconeogenesis R-HSA-70263 0.569622 0.244 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.480694 0.318 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.367273 0.435 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.508927 0.293 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.470539 0.327 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 0.470539 0.327 0 0
Tandem pore domain potassium channels R-HSA-1296346 0.497876 0.303 0 0
Josephin domain DUBs R-HSA-5689877 0.497876 0.303 0 0
Formation of definitive endoderm R-HSA-9823730 0.381846 0.418 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.497876 0.303 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.507838 0.294 0 0
PKR-mediated signaling R-HSA-9833482 0.324715 0.488 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.309874 0.509 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 0.441715 0.355 0 0
Interleukin-37 signaling R-HSA-9008059 0.298134 0.526 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.355498 0.449 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.436678 0.360 0 0
Suppression of apoptosis R-HSA-9635465 0.523803 0.281 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 0.548393 0.261 0 0
Inflammasomes R-HSA-622312 0.537722 0.269 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.568517 0.245 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.392718 0.406 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.115872 0.936 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.521765 0.283 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.131288 0.882 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.470539 0.327 1 1
SARS-CoV-1-host interactions R-HSA-9692914 0.178973 0.747 0 0
Cellular response to chemical stress R-HSA-9711123 0.458328 0.339 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.324477 0.489 0 0
Nephron development R-HSA-9831926 0.344049 0.463 0 0
Interleukin-35 Signalling R-HSA-8984722 0.571715 0.243 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.297873 0.526 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.258639 0.587 0 0
G0 and Early G1 R-HSA-1538133 0.326824 0.486 0 0
Transport of RCbl within the body R-HSA-9758890 0.523803 0.281 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.439664 0.357 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.571715 0.243 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.521765 0.283 0 0
Signaling by LTK R-HSA-9842663 0.571715 0.243 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.488672 0.311 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.344049 0.463 0 0
GAB1 signalosome R-HSA-180292 0.344049 0.463 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.117332 0.931 0 0
Regulation of beta-cell development R-HSA-186712 0.283676 0.547 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.505443 0.296 0 0
Dissolution of Fibrin Clot R-HSA-75205 0.523803 0.281 0 0
Chromosome Maintenance R-HSA-73886 0.573265 0.242 0 0
Autophagy R-HSA-9612973 0.573429 0.242 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.577087 0.239 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.580238 0.236 0 0
Gap junction trafficking and regulation R-HSA-157858 0.581539 0.235 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.582267 0.235 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.583349 0.234 0 0
Nucleotide Excision Repair R-HSA-5696398 0.586202 0.232 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.588621 0.230 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.592361 0.227 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.592361 0.227 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.592361 0.227 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.593833 0.226 0 0
Processing of SMDT1 R-HSA-8949664 0.593833 0.226 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 0.593833 0.226 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.593833 0.226 0 0
Interleukin-6 signaling R-HSA-1059683 0.593833 0.226 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 0.593833 0.226 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.593833 0.226 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.593833 0.226 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 0.593833 0.226 0 0
DNA strand elongation R-HSA-69190 0.597801 0.223 0 0
Signaling by WNT in cancer R-HSA-4791275 0.597801 0.223 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.597801 0.223 0 0
Macroautophagy R-HSA-1632852 0.598216 0.223 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.602308 0.220 0 0
Synthesis of DNA R-HSA-69239 0.602510 0.220 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.606152 0.217 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.610678 0.214 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.610678 0.214 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.611873 0.213 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.611873 0.213 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.611873 0.213 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.611873 0.213 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.611873 0.213 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.612108 0.213 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.612108 0.213 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.612176 0.213 0 0
Cell junction organization R-HSA-446728 0.613854 0.212 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.614811 0.211 0 0
Removal of the Flap Intermediate R-HSA-69166 0.614811 0.211 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.614811 0.211 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 0.614811 0.211 0 0
cGMP effects R-HSA-418457 0.614811 0.211 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.614811 0.211 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.614811 0.211 0 0
Zinc transporters R-HSA-435354 0.614811 0.211 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.616010 0.210 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.616010 0.210 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.616010 0.210 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.616010 0.210 0 0
Generic Transcription Pathway R-HSA-212436 0.622392 0.206 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.625565 0.204 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.625565 0.204 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.627064 0.203 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.627064 0.203 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.627064 0.203 0 0
Meiotic synapsis R-HSA-1221632 0.627064 0.203 0 0
Signaling by ERBB4 R-HSA-1236394 0.631253 0.200 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.634706 0.197 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.634706 0.197 0 0
Translesion synthesis by REV1 R-HSA-110312 0.634706 0.197 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.634706 0.197 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.634706 0.197 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.634706 0.197 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.634706 0.197 0 0
p38MAPK events R-HSA-171007 0.634706 0.197 0 0
Biotin transport and metabolism R-HSA-196780 0.634706 0.197 0 0
Protein repair R-HSA-5676934 0.634706 0.197 0 0
Erythropoietin activates RAS R-HSA-9027284 0.634706 0.197 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.634706 0.197 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 0.634706 0.197 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.634706 0.197 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.634706 0.197 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.634706 0.197 0 0
Protein methylation R-HSA-8876725 0.634706 0.197 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.634706 0.197 0 0
p75NTR signals via NF-kB R-HSA-193639 0.634706 0.197 0 0
Formation of the anterior neural plate R-HSA-9823739 0.634706 0.197 0 0
Signal amplification R-HSA-392518 0.638880 0.195 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.638880 0.195 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.638880 0.195 0 0
Mitophagy R-HSA-5205647 0.638880 0.195 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.638880 0.195 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.638880 0.195 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.640595 0.193 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.648509 0.188 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.648509 0.188 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.649255 0.188 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.649781 0.187 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.651820 0.186 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.651820 0.186 0 0
PERK regulates gene expression R-HSA-381042 0.651820 0.186 0 0
Signalling to ERKs R-HSA-187687 0.651820 0.186 0 0
Translesion synthesis by POLI R-HSA-5656121 0.653575 0.185 0 0
Phosphorylation of the APC/C R-HSA-176412 0.653575 0.185 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.653575 0.185 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 0.653575 0.185 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.653575 0.185 0 0
Phase 4 - resting membrane potential R-HSA-5576886 0.653575 0.185 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.653575 0.185 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 0.653575 0.185 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.653575 0.185 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.653575 0.185 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.658897 0.181 0 0
Ion homeostasis R-HSA-5578775 0.658897 0.181 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.658897 0.181 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.658897 0.181 0 0
Gastrulation R-HSA-9758941 0.658956 0.181 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.664387 0.178 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.664387 0.178 0 0
Calmodulin induced events R-HSA-111933 0.664387 0.178 0 0
CaM pathway R-HSA-111997 0.664387 0.178 0 0
G1/S-Specific Transcription R-HSA-69205 0.664387 0.178 0 0
Viral Infection Pathways R-HSA-9824446 0.664631 0.177 0 0
Potential therapeutics for SARS R-HSA-9679191 0.665361 0.177 0 0
PCP/CE pathway R-HSA-4086400 0.667679 0.175 0 0
RNA Polymerase I Transcription R-HSA-73864 0.667679 0.175 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.668872 0.175 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.671470 0.173 0 0
Translesion synthesis by POLK R-HSA-5655862 0.671470 0.173 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.671470 0.173 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.671470 0.173 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.671470 0.173 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.671470 0.173 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.671470 0.173 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.671470 0.173 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.671470 0.173 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.671470 0.173 0 0
tRNA modification in the mitochondrion R-HSA-6787450 0.671470 0.173 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 0.671470 0.173 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.671693 0.173 0 0
Neuronal System R-HSA-112316 0.675458 0.170 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.679004 0.168 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.679004 0.168 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.681650 0.166 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.684940 0.164 0 0
L1CAM interactions R-HSA-373760 0.685543 0.164 0 0
Membrane Trafficking R-HSA-199991 0.685906 0.164 0 0
MET promotes cell motility R-HSA-8875878 0.688422 0.162 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.688442 0.162 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.688442 0.162 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.688442 0.162 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.688442 0.162 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.688442 0.162 0 0
Choline catabolism R-HSA-6798163 0.688442 0.162 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.688442 0.162 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.688442 0.162 0 0
Rab regulation of trafficking R-HSA-9007101 0.692497 0.160 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.693331 0.159 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.698218 0.156 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.699733 0.155 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.699900 0.155 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.699900 0.155 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.701561 0.154 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.701749 0.154 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.704538 0.152 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 0.704538 0.152 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.704538 0.152 0 0
Polo-like kinase mediated events R-HSA-156711 0.704538 0.152 0 0
Presynaptic function of Kainate receptors R-HSA-500657 0.704538 0.152 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.704538 0.152 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.704538 0.152 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.704538 0.152 0 0
Platelet sensitization by LDL R-HSA-432142 0.704538 0.152 0 0
Mismatch Repair R-HSA-5358508 0.704538 0.152 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 0.704538 0.152 0 0
Aquaporin-mediated transport R-HSA-445717 0.707492 0.150 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.707492 0.150 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.711024 0.148 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.711024 0.148 0 0
Aggrephagy R-HSA-9646399 0.711024 0.148 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.713976 0.146 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.716546 0.145 0 0
Heme signaling R-HSA-9707616 0.716546 0.145 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.717539 0.144 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.719285 0.143 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.719804 0.143 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.719804 0.143 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 0.719804 0.143 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 0.719804 0.143 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.719804 0.143 0 0
Specification of the neural plate border R-HSA-9834899 0.719804 0.143 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.719804 0.143 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.719804 0.143 0 0
Diseases of hemostasis R-HSA-9671793 0.719804 0.143 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.719804 0.143 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.719804 0.143 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.721800 0.142 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.721800 0.142 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.721800 0.142 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.725015 0.140 0 0
Leishmania phagocytosis R-HSA-9664417 0.725015 0.140 0 0
Parasite infection R-HSA-9664407 0.725015 0.140 0 0
Meiosis R-HSA-1500620 0.725289 0.139 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.725382 0.139 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.725382 0.139 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.728006 0.138 0 0
Interferon Signaling R-HSA-913531 0.730415 0.136 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 0.732236 0.135 0 0
Heme biosynthesis R-HSA-189451 0.732236 0.135 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.732879 0.135 0 0
IGF1R signaling cascade R-HSA-2428924 0.734001 0.134 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.734001 0.134 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.734281 0.134 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.734281 0.134 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.734281 0.134 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.734281 0.134 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.734281 0.134 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 0.734281 0.134 0 0
Acyl chain remodelling of PI R-HSA-1482922 0.734281 0.134 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.734281 0.134 0 0
Protein hydroxylation R-HSA-9629569 0.734281 0.134 0 0
Signaling by NODAL R-HSA-1181150 0.734281 0.134 0 0
Nephrin family interactions R-HSA-373753 0.734281 0.134 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.740311 0.131 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.742336 0.129 0 0
Ca-dependent events R-HSA-111996 0.742336 0.129 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.742405 0.129 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 0.748012 0.126 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.748012 0.126 0 0
G-protein activation R-HSA-202040 0.748012 0.126 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 0.748012 0.126 0 0
Lagging Strand Synthesis R-HSA-69186 0.748012 0.126 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.748012 0.126 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.748012 0.126 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.748012 0.126 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 0.748012 0.126 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.748012 0.126 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 0.748012 0.126 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 0.748012 0.126 0 0
Defective pyroptosis R-HSA-9710421 0.752109 0.124 0 0
Signaling by FGFR4 R-HSA-5654743 0.752109 0.124 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.752109 0.124 0 0
Gene Silencing by RNA R-HSA-211000 0.754559 0.122 0 0
Selective autophagy R-HSA-9663891 0.754702 0.122 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.760886 0.119 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.761033 0.119 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.761033 0.119 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.761033 0.119 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 0.761033 0.119 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.761033 0.119 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.761033 0.119 0 0
Serine metabolism R-HSA-977347 0.761033 0.119 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.761561 0.118 0 0
Gap junction trafficking R-HSA-190828 0.761561 0.118 0 0
DAP12 interactions R-HSA-2172127 0.761561 0.118 0 0
ER-Phagosome pathway R-HSA-1236974 0.761663 0.118 0 0
Transcription of the HIV genome R-HSA-167172 0.766350 0.116 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.770699 0.113 0 0
DAG and IP3 signaling R-HSA-1489509 0.770699 0.113 0 0
Signaling by FGFR3 R-HSA-5654741 0.770699 0.113 0 0
FGFR2 alternative splicing R-HSA-6803529 0.773383 0.112 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.773383 0.112 0 0
Cellular hexose transport R-HSA-189200 0.773383 0.112 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.773383 0.112 0 0
Ethanol oxidation R-HSA-71384 0.773383 0.112 0 0
mTORC1-mediated signalling R-HSA-166208 0.773383 0.112 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 0.773383 0.112 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.773383 0.112 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 0.773383 0.112 0 0
LDL clearance R-HSA-8964038 0.773383 0.112 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 0.773383 0.112 0 0
Neutrophil degranulation R-HSA-6798695 0.775810 0.110 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.779529 0.108 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.779529 0.108 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.779529 0.108 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.779529 0.108 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.779529 0.108 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.781285 0.107 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.781285 0.107 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.783910 0.106 0 0
Inositol phosphate metabolism R-HSA-1483249 0.784964 0.105 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.785095 0.105 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.785095 0.105 0 0
Interleukin-20 family signaling R-HSA-8854691 0.785095 0.105 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.785095 0.105 0 0
Mitochondrial mRNA modification R-HSA-9937008 0.785095 0.105 0 0
Growth hormone receptor signaling R-HSA-982772 0.785095 0.105 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.785122 0.105 0 0
Signaling by Interleukins R-HSA-449147 0.792519 0.101 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.794182 0.100 0 0
Circadian clock R-HSA-9909396 0.794916 0.100 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.795137 0.100 0 0
Thromboxane signalling through TP receptor R-HSA-428930 0.796202 0.099 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.796202 0.099 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.796202 0.099 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.796202 0.099 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.796202 0.099 0 0
Interleukin-6 family signaling R-HSA-6783589 0.796202 0.099 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 0.796202 0.099 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.796202 0.099 0 0
GPER1 signaling R-HSA-9634597 0.796300 0.099 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.796374 0.099 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.796374 0.099 0 0
Ub-specific processing proteases R-HSA-5689880 0.796374 0.099 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.800239 0.097 0 0
HCMV Early Events R-HSA-9609690 0.802533 0.096 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.802533 0.096 0 0
DNA Damage Bypass R-HSA-73893 0.804255 0.095 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 0.806736 0.093 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 0.806736 0.093 0 0
G protein gated Potassium channels R-HSA-1296059 0.806736 0.093 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.806736 0.093 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.806736 0.093 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.806736 0.093 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.806736 0.093 0 0
Interleukin-7 signaling R-HSA-1266695 0.806736 0.093 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.806736 0.093 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 0.806736 0.093 0 0
Signaling by NOTCH4 R-HSA-9013694 0.808791 0.092 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.811932 0.090 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.815194 0.089 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.816726 0.088 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.816726 0.088 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.816726 0.088 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.816726 0.088 0 0
Metalloprotease DUBs R-HSA-5689901 0.816726 0.088 0 0
Urea cycle R-HSA-70635 0.816726 0.088 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.816726 0.088 1 0
Potassium Channels R-HSA-1296071 0.817548 0.087 0 0
Co-inhibition by PD-1 R-HSA-389948 0.818870 0.087 0 0
Meiotic recombination R-HSA-912446 0.819339 0.087 0 0
SARS-CoV Infections R-HSA-9679506 0.821367 0.085 0 0
UCH proteinases R-HSA-5689603 0.821414 0.085 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.821749 0.085 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.822563 0.085 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.824086 0.084 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.826201 0.083 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.826201 0.083 0 0
Packaging Of Telomere Ends R-HSA-171306 0.826201 0.083 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.826201 0.083 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.826201 0.083 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 0.826201 0.083 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.826201 0.083 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.826201 0.083 0 0
Insulin processing R-HSA-264876 0.826201 0.083 0 0
Maturation of hRSV A proteins R-HSA-9828806 0.826201 0.083 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.826484 0.083 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.826484 0.083 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.827455 0.082 0 0
Regulation of insulin secretion R-HSA-422356 0.828389 0.082 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.833320 0.079 0 0
Cholesterol biosynthesis R-HSA-191273 0.833320 0.079 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.833373 0.079 0 0
HATs acetylate histones R-HSA-3214847 0.833605 0.079 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.835186 0.078 0 0
HIV elongation arrest and recovery R-HSA-167287 0.835186 0.078 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.835186 0.078 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.835186 0.078 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.835186 0.078 0 0
Telomere Extension By Telomerase R-HSA-171319 0.835186 0.078 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.835186 0.078 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.835186 0.078 0 0
Iron assimilation using enterobactin R-HSA-9638334 0.835186 0.078 0 0
Pyroptosis R-HSA-5620971 0.835186 0.078 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.835186 0.078 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.838050 0.077 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.840014 0.076 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.841488 0.075 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.841634 0.075 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.843707 0.074 0 0
mRNA Capping R-HSA-72086 0.843707 0.074 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.843707 0.074 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.843707 0.074 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.843707 0.074 0 0
Glucagon-type ligand receptors R-HSA-420092 0.843707 0.074 0 0
DARPP-32 events R-HSA-180024 0.843707 0.074 0 0
Signaling by Erythropoietin R-HSA-9006335 0.843707 0.074 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.843707 0.074 0 0
Signaling by FGFR2 R-HSA-5654738 0.844536 0.073 0 0
HCMV Infection R-HSA-9609646 0.845702 0.073 0 0
G alpha (z) signalling events R-HSA-418597 0.846415 0.072 0 0
Signaling by NOTCH3 R-HSA-9012852 0.846415 0.072 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.846616 0.072 0 0
PI Metabolism R-HSA-1483255 0.848466 0.071 0 0
Cell-cell junction organization R-HSA-421270 0.848890 0.071 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.851788 0.070 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.851788 0.070 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.851788 0.070 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.851788 0.070 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.851788 0.070 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.851788 0.070 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.852582 0.069 0 0
Signaling by FGFR1 R-HSA-5654736 0.852582 0.069 0 0
Opioid Signalling R-HSA-111885 0.857738 0.067 0 0
SLC transporter disorders R-HSA-5619102 0.858211 0.066 0 0
IRS-mediated signalling R-HSA-112399 0.858523 0.066 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 0.859451 0.066 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.859451 0.066 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.859451 0.066 0 0
Trafficking of AMPA receptors R-HSA-399719 0.859451 0.066 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.860132 0.065 0 0
RSV-host interactions R-HSA-9833110 0.862190 0.064 0 0
Dual incision in TC-NER R-HSA-6782135 0.864244 0.063 0 0
Inwardly rectifying K+ channels R-HSA-1296065 0.866719 0.062 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.866719 0.062 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.866719 0.062 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.868912 0.061 0 0
Extension of Telomeres R-HSA-180786 0.869752 0.061 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.869752 0.061 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.869752 0.061 0 0
Platelet homeostasis R-HSA-418346 0.870737 0.060 0 0
tRNA processing R-HSA-72306 0.872072 0.059 0 0
Signaling by NTRKs R-HSA-166520 0.872470 0.059 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.873016 0.059 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.873611 0.059 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.873611 0.059 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.873611 0.059 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.873611 0.059 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.873611 0.059 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.874338 0.058 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.874427 0.058 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.875054 0.058 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.878823 0.056 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.880148 0.055 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.880148 0.055 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.880148 0.055 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.880148 0.055 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.880148 0.055 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.880148 0.055 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.880156 0.055 0 0
PLC beta mediated events R-HSA-112043 0.880156 0.055 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.880156 0.055 0 0
Adherens junctions interactions R-HSA-418990 0.882689 0.054 0 0
Developmental Cell Lineages R-HSA-9734767 0.883243 0.054 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.884795 0.053 0 0
Mitochondrial protein import R-HSA-1268020 0.885065 0.053 0 0
eNOS activation R-HSA-203615 0.886346 0.052 0 0
Dual Incision in GG-NER R-HSA-5696400 0.886346 0.052 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.886346 0.052 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.886346 0.052 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.886346 0.052 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.886346 0.052 0 0
Gap junction assembly R-HSA-190861 0.886346 0.052 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.886346 0.052 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.886346 0.052 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.886346 0.052 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.892225 0.050 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.892225 0.050 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.892225 0.050 0 0
Regulation of Apoptosis R-HSA-169911 0.892225 0.050 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.892225 0.050 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.892225 0.050 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.893160 0.049 0 0
Insulin receptor signalling cascade R-HSA-74751 0.894330 0.049 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.895188 0.048 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.897800 0.047 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.897800 0.047 0 0
HSF1 activation R-HSA-3371511 0.897800 0.047 0 0
GPVI-mediated activation cascade R-HSA-114604 0.897800 0.047 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.897800 0.047 0 0
Triglyceride catabolism R-HSA-163560 0.897800 0.047 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.897800 0.047 0 0
HCMV Late Events R-HSA-9610379 0.900999 0.045 0 0
Voltage gated Potassium channels R-HSA-1296072 0.903086 0.044 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.903086 0.044 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.903086 0.044 0 0
Degradation of DVL R-HSA-4641258 0.903086 0.044 0 0
Degradation of AXIN R-HSA-4641257 0.903086 0.044 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.903086 0.044 0 0
Cleavage of the damaged purine R-HSA-110331 0.903086 0.044 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.903086 0.044 0 0
Collagen chain trimerization R-HSA-8948216 0.903086 0.044 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.906697 0.043 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.906931 0.042 0 0
G-protein mediated events R-HSA-112040 0.906931 0.042 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.906931 0.042 0 0
Kidney development R-HSA-9830369 0.906931 0.042 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.907265 0.042 0 0
Integration of energy metabolism R-HSA-163685 0.907265 0.042 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.908100 0.042 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.908100 0.042 0 0
Depurination R-HSA-73927 0.908100 0.042 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.908100 0.042 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.908100 0.042 0 0
Signaling by TGFB family members R-HSA-9006936 0.909207 0.041 0 0
Interferon alpha/beta signaling R-HSA-909733 0.910002 0.041 0 0
Regulated Necrosis R-HSA-5218859 0.910810 0.041 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.910810 0.041 0 0
Signaling by WNT R-HSA-195721 0.911841 0.040 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.912854 0.040 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.912854 0.040 0 0
Pentose phosphate pathway R-HSA-71336 0.912854 0.040 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.912854 0.040 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.912854 0.040 0 0
Mitochondrial protein degradation R-HSA-9837999 0.912877 0.040 0 0
PTEN Regulation R-HSA-6807070 0.915531 0.038 0 0
Mitochondrial biogenesis R-HSA-1592230 0.915879 0.038 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.917363 0.037 0 0
HIV Transcription Elongation R-HSA-167169 0.917363 0.037 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.917363 0.037 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.917363 0.037 0 0
Attenuation phase R-HSA-3371568 0.917363 0.037 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.917363 0.037 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.917363 0.037 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.917363 0.037 0 0
Diseases of Immune System R-HSA-5260271 0.917363 0.037 0 0
Generation of second messenger molecules R-HSA-202433 0.917363 0.037 0 0
Tryptophan catabolism R-HSA-71240 0.917363 0.037 0 0
Glycogen metabolism R-HSA-8982491 0.917363 0.037 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.918116 0.037 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.921555 0.035 0 0
Hedgehog 'on' state R-HSA-5632684 0.921555 0.035 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.921555 0.035 0 0
Metabolism of porphyrins R-HSA-189445 0.921555 0.035 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.921639 0.035 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.921639 0.035 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.921639 0.035 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 0.921639 0.035 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.921639 0.035 0 0
Ion channel transport R-HSA-983712 0.923448 0.035 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.924439 0.034 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.924857 0.034 0 0
Telomere Maintenance R-HSA-157579 0.925026 0.034 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.925694 0.034 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.925694 0.034 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.925694 0.034 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.925694 0.034 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.925694 0.034 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.925694 0.034 0 0
Signaling by FGFR R-HSA-190236 0.927810 0.033 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.929539 0.032 0 0
Activation of GABAB receptors R-HSA-991365 0.929539 0.032 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.929539 0.032 0 0
GABA B receptor activation R-HSA-977444 0.929539 0.032 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.929539 0.032 0 0
Depyrimidination R-HSA-73928 0.929539 0.032 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.929539 0.032 0 0
MHC class II antigen presentation R-HSA-2132295 0.931505 0.031 0 0
Hedgehog 'off' state R-HSA-5610787 0.933096 0.030 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.933185 0.030 0 0
Iron uptake and transport R-HSA-917937 0.933994 0.030 0 0
Methylation R-HSA-156581 0.936643 0.028 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.936643 0.028 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.939922 0.027 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.939922 0.027 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.939922 0.027 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.939922 0.027 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.939922 0.027 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.939922 0.027 0 0
Somitogenesis R-HSA-9824272 0.939922 0.027 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 0.939922 0.027 0 0
ABC transporter disorders R-HSA-5619084 0.942073 0.026 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.943032 0.025 0 0
Diseases of DNA repair R-HSA-9675135 0.943032 0.025 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.943635 0.025 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 0.945981 0.024 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.945981 0.024 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.945981 0.024 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.945981 0.024 0 0
Synthesis of PC R-HSA-1483191 0.945981 0.024 0 0
Interleukin-1 family signaling R-HSA-446652 0.946099 0.024 0 0
Intraflagellar transport R-HSA-5620924 0.948777 0.023 0 0
NGF-stimulated transcription R-HSA-9031628 0.948777 0.023 0 0
Metal ion SLC transporters R-HSA-425410 0.948777 0.023 0 0
Transmission across Chemical Synapses R-HSA-112315 0.950880 0.022 0 0
Vesicle-mediated transport R-HSA-5653656 0.951179 0.022 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.951429 0.022 0 0
Chemokine receptors bind chemokines R-HSA-380108 0.951429 0.022 0 0
Cardiac conduction R-HSA-5576891 0.951808 0.021 0 0
Stimuli-sensing channels R-HSA-2672351 0.952745 0.021 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.953944 0.020 0 0
PI3K Cascade R-HSA-109704 0.953944 0.020 0 0
Azathioprine ADME R-HSA-9748787 0.953944 0.020 0 0
TCR signaling R-HSA-202403 0.956309 0.019 0 0
HSF1-dependent transactivation R-HSA-3371571 0.956328 0.019 0 0
Complex IV assembly R-HSA-9864848 0.956328 0.019 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.956328 0.019 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.956328 0.019 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.956328 0.019 0 0
Parasitic Infection Pathways R-HSA-9824443 0.956918 0.019 0 0
Leishmania infection R-HSA-9658195 0.956918 0.019 0 0
Infectious disease R-HSA-5663205 0.956978 0.019 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.958590 0.018 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.960734 0.017 0 0
Nucleotide biosynthesis R-HSA-8956320 0.960734 0.017 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.962767 0.016 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 0.964696 0.016 0 0
Neurotransmitter release cycle R-HSA-112310 0.967403 0.014 0 0
Base Excision Repair R-HSA-73884 0.967403 0.014 0 0
Downstream TCR signaling R-HSA-202424 0.967403 0.014 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.969902 0.013 0 0
Phospholipid metabolism R-HSA-1483257 0.970473 0.013 0 0
Peroxisomal protein import R-HSA-9033241 0.971461 0.013 0 0
Triglyceride metabolism R-HSA-8979227 0.971461 0.013 0 0
Signaling by Insulin receptor R-HSA-74752 0.971508 0.013 0 0
RAB geranylgeranylation R-HSA-8873719 0.972940 0.012 0 0
GABA receptor activation R-HSA-977443 0.972940 0.012 0 0
Metabolism of polyamines R-HSA-351202 0.972940 0.012 0 0
tRNA Aminoacylation R-HSA-379724 0.972940 0.012 0 0
Collagen formation R-HSA-1474290 0.973963 0.011 0 0
Collagen degradation R-HSA-1442490 0.974342 0.011 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.975112 0.011 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.976278 0.010 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.977053 0.010 0 0
Mitochondrial translation elongation R-HSA-5389840 0.977266 0.010 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.977266 0.010 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.977266 0.010 0 0
CD22 mediated BCR regulation R-HSA-5690714 0.978127 0.010 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.979239 0.009 0 0
Cellular response to hypoxia R-HSA-1234174 0.979260 0.009 0 0
Protein localization R-HSA-9609507 0.980091 0.009 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.980335 0.009 0 0
Disease R-HSA-1643685 0.980608 0.009 0 0
Nicotinate metabolism R-HSA-196807 0.981354 0.008 0 0
Interleukin-1 signaling R-HSA-9020702 0.981890 0.008 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.982321 0.008 0 0
COPII-mediated vesicle transport R-HSA-204005 0.984106 0.007 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.984106 0.007 0 0
Metabolism of cofactors R-HSA-8978934 0.984930 0.007 0 0
Metal ion assimilation from the host R-HSA-9638482 0.984930 0.007 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.985596 0.006 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.985711 0.006 0 0
Cilium Assembly R-HSA-5617833 0.986047 0.006 0 0
Ca2+ pathway R-HSA-4086398 0.986452 0.006 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 0.986452 0.006 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.987154 0.006 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.987821 0.005 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.988560 0.005 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.988560 0.005 0 0
Signaling by Hedgehog R-HSA-5358351 0.988609 0.005 0 0
Adaptive Immune System R-HSA-1280218 0.989127 0.005 0 0
Interleukin-10 signaling R-HSA-6783783 0.989619 0.005 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.989619 0.005 0 0
Integrin cell surface interactions R-HSA-216083 0.989619 0.005 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 0.990157 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.990926 0.004 0 0
Amyloid fiber formation R-HSA-977225 0.991152 0.004 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.991347 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.991733 0.004 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.992851 0.003 0 0
G alpha (q) signalling events R-HSA-416476 0.992949 0.003 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.993141 0.003 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.993141 0.003 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.993418 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.993573 0.003 0 0
Metabolism of amino acids and derivatives R-HSA-71291 0.993633 0.003 0 0
Pyruvate metabolism R-HSA-70268 0.993906 0.003 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.994040 0.003 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.994040 0.003 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.994807 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.995574 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.995574 0.002 0 0
Neddylation R-HSA-8951664 0.995782 0.002 0 0
FCGR activation R-HSA-2029481 0.995804 0.002 0 0
Bacterial Infection Pathways R-HSA-9824439 0.996295 0.002 0 0
Mitochondrial translation initiation R-HSA-5368286 0.996953 0.001 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.996953 0.001 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.996953 0.001 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.996953 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 0.997261 0.001 0 0
G alpha (s) signalling events R-HSA-418555 0.997475 0.001 0 0
Mitochondrial translation R-HSA-5368287 0.997574 0.001 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.997666 0.001 0 0
G alpha (i) signalling events R-HSA-418594 0.997831 0.001 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 0.997902 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.998264 0.001 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.998306 0.001 0 0
Mitochondrial translation termination R-HSA-5419276 0.998394 0.001 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.998394 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.998631 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 0.998701 0.001 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.998702 0.001 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.998894 0.000 0 0
Toll-like Receptor Cascades R-HSA-168898 0.998962 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999058 0.000 0 0
Interferon gamma signaling R-HSA-877300 0.999157 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999186 0.000 0 0
GPCR downstream signalling R-HSA-388396 0.999244 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.999448 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.999552 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.999556 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.999593 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.999593 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.999620 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999753 0.000 0 0
Immune System R-HSA-168256 0.999771 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 0.999845 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 0.999870 0.000 0 0
Metabolism of nucleotides R-HSA-15869 0.999873 0.000 0 0
Signaling by GPCR R-HSA-372790 0.999926 0.000 0 0
Innate Immune System R-HSA-168249 0.999937 0.000 0 0
Metabolism of proteins R-HSA-392499 0.999956 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999972 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 0.999976 0.000 0 0
Diseases of glycosylation R-HSA-3781865 0.999980 0.000 0 0
Post-translational protein modification R-HSA-597592 0.999981 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.999984 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 0.999988 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 0.999989 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 0.999993 0.000 0 0
Transport of small molecules R-HSA-382551 0.999996 0.000 0 0
Drug ADME R-HSA-9748784 0.999997 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 0.999997 0.000 0 0
Extracellular matrix organization R-HSA-1474244 0.999999 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 0.999999 0.000 0 0
Diseases of metabolism R-HSA-5668914 0.999999 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Biological oxidations R-HSA-211859 1.000000 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways