CLK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
O00488	S93	Sugiyama	ZNF593 ZT86	STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O43852	S300	Sugiyama	CALU	NKDGKLTKEEIVDKyDLFVGsQAtDFGEALVRHDEF_____
O43852	T303	Sugiyama	CALU	GKLTKEEIVDKyDLFVGsQAtDFGEALVRHDEF________
O60343	S588	Sugiyama	TBC1D4 AS160 KIAA0603	tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60829	S7	EPSD\|PSP	PAGE4 GAGEC1 JM27	______________MSARVRsRsRGRGDGQEAPDVVAFVAP
O60829	S73	EPSD\|PSP	PAGE4 GAGEC1 JM27	PIEERKVEGDCQEMDLEKtRsERGDGsDVKEKtPPNPKHAK
O60829	S79	EPSD\|PSP	PAGE4 GAGEC1 JM27	VEGDCQEMDLEKtRsERGDGsDVKEKtPPNPKHAKtKEAGD
O60829	S9	EPSD\|PSP	PAGE4 GAGEC1 JM27	____________MSARVRsRsRGRGDGQEAPDVVAFVAPGE
O60829	T51	EPSD\|PSP	PAGE4 GAGEC1 JM27	QQEEPPTDNQDIEPGQEREGtPPIEERKVEGDCQEMDLEKt
O60829	T71	EPSD\|PSP	PAGE4 GAGEC1 JM27	tPPIEERKVEGDCQEMDLEKtRsERGDGsDVKEKtPPNPKH
O60829	T85	EPSD\|PSP	PAGE4 GAGEC1 JM27	EMDLEKtRsERGDGsDVKEKtPPNPKHAKtKEAGDGQP___
O60829	T94	EPSD\|PSP	PAGE4 GAGEC1 JM27	ERGDGsDVKEKtPPNPKHAKtKEAGDGQP____________
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P00558	Y161	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733	Y44	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205	Y161	Sugiyama	PGK2 PGKB	KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P10809	T381	Sugiyama	HSPD1 HSP60	KGDKAQIEKRIQEIIEQLDVttsEyEKEKLNERLAKLsDGV
P10809	Y385	Sugiyama	HSPD1 HSP60	AQIEKRIQEIIEQLDVttsEyEKEKLNERLAKLsDGVAVLK
P18031	S242	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	PTPN1 PTP1B	SGTFCLADTCLLLMDKRKDPssVDIKKVLLEMRKFRMGLIQ
P18031	S243	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	PTPN1 PTP1B	GTFCLADTCLLLMDKRKDPssVDIKKVLLEMRKFRMGLIQT
P18031	S50	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	PTPN1 PTP1B	FPCRVAKLPKNKNRNRyRDVsPFDHSRIKLHQEDNDyINAs
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P43243	S195	Sugiyama	MATR3 KIAA0723	RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P49760	S142	GPS6\|SIGNOR\|EPSD\|Sugiyama	CLK2	RRRSRtFSRSSSQHSSRRAKsVEDDAEGHLIYHVGDWLQER
P49760	S167	Sugiyama	CLK2	AEGHLIYHVGDWLQERYEIVsTLGEGtFGRVVQCVDHRRGG
P49760	S426	Sugiyama	CLK2	RKTRKQKYFYRGRLDWDENTsAGRyVRENCKPLRRYLTSEA
P49760	S98	GPS6\|EPSD	CLK2	RRNDYSRDRGDAYyDTDYRHsYEyQRENSSYRSQRSSRRKH
P49760	T173	Sugiyama	CLK2	YHVGDWLQERYEIVsTLGEGtFGRVVQCVDHRRGGARVALK
P49760	Y430	Sugiyama	CLK2	KQKYFYRGRLDWDENTsAGRyVRENCKPLRRYLTSEAEEHH
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
Q13242	S211	Sugiyama	SRSF9 SFRS9 SRP30C	GYsRsRSGsRGRDsPyQsRGsPHyFsPFRPy__________
Q13242	S216	Sugiyama	SRSF9 SFRS9 SRP30C	RSGsRGRDsPyQsRGsPHyFsPFRPy_______________
Q14004	S383	Sugiyama	CDK13 CDC2L CDC2L5 CHED KIAA1791	sRRRSPSYSRHSSYERGGDVsPsPyssSsWRRsRsPysPVL
Q14004	S385	Sugiyama	CDK13 CDC2L CDC2L5 CHED KIAA1791	RRSPSYSRHSSYERGGDVsPsPyssSsWRRsRsPysPVLRR
Q14152	S1188	Sugiyama	EIF3A EIF3S10 KIAA0139	PWRPLVKPGGWREKEKAREEsWGPPRESRPsEEREWDREKE
Q14978	S686	Sugiyama	NOLC1 KIAA0035 NS5ATP13	KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q6UN15	S492	Sugiyama	FIP1L1 FIP1 RHE	DRDRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAE
Q6UN15	T494	Sugiyama	FIP1L1 FIP1 RHE	DRDRERERTRERERERDHsPtPsVFNsDEERyRYREYAERG
Q8IWX8	S817	Sugiyama	CHERP DAN26 SCAF6	QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8	T819	Sugiyama	CHERP DAN26 SCAF6	RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q96MH2	S76	Sugiyama	HEXIM2 L3	EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96MU7	S308	Sugiyama	YTHDC1 KIAA1966 YT521	GSGTDGsDEKKKERKRARGIsPIVFDRsGssAsESYAGsEK
Q96S44	T8	Sugiyama	TP53RK C20orf64 PRPK	_____________MAAARAttPADGEEPAPEAEALAAARER
Q96T37	S670	Sugiyama	RBM15 OTT OTT1	GRHLDRsPEsDRPRKRHCAPsPDRsPELsssRDRYNsDNDR
Q9H7N4	S498	Sugiyama	SCAF1 SFRS19 SRA1	GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4	S500	Sugiyama	SCAF1 SFRS19 SRA1	LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9NRR4	S217	Sugiyama	DROSHA RN3 RNASE3L RNASEN	NNSSSPHFRHLPPYPLPKAPsERRsPERLKHYDDHRHRDHS
Q9UII2	S63	Sugiyama	ATP5IF1 ATPI ATPIF1	AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S1648	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	APRALPRRSRSGSSSKGRGPsPEGssstEssPEHPPKSRTA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	T856	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFEss

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.522434e-10	9.186
mRNA Splicing - Major Pathway	R-HSA-72163	8.677769e-08	7.062
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.022874e-07	6.990
mRNA Splicing	R-HSA-72172	1.609405e-07	6.793
mRNA 3'-end processing	R-HSA-72187	4.289060e-07	6.368
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.898395e-07	6.310
Cell Cycle	R-HSA-1640170	6.332110e-07	6.198
RNA Polymerase II Transcription Termination	R-HSA-73856	1.173629e-06	5.930
Cell Cycle, Mitotic	R-HSA-69278	2.792585e-06	5.554
Chromatin organization	R-HSA-4839726	6.105619e-06	5.214
Chromatin modifying enzymes	R-HSA-3247509	1.129629e-05	4.947
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.136396e-05	4.670
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	6.345984e-05	4.198
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.322069e-04	3.634
M Phase	R-HSA-68886	3.761592e-04	3.425
Regulation of TP53 Activity	R-HSA-5633007	4.498504e-04	3.347
Gene expression (Transcription)	R-HSA-74160	4.328786e-04	3.364
PKMTs methylate histone lysines	R-HSA-3214841	5.094939e-04	3.293
Apoptotic execution phase	R-HSA-75153	5.379410e-04	3.269
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.226928e-04	3.206
Apoptotic cleavage of cellular proteins	R-HSA-111465	6.344531e-04	3.198
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	6.709313e-04	3.173
Mitotic Prometaphase	R-HSA-68877	6.999889e-04	3.155
Regulation of TP53 Expression	R-HSA-6804754	8.039475e-04	3.095
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	8.164307e-04	3.088
Regulation of MECP2 expression and activity	R-HSA-9022692	7.917016e-04	3.101
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.051127e-03	2.978
Centrosome maturation	R-HSA-380287	1.078414e-03	2.967
Transcriptional Regulation by TP53	R-HSA-3700989	1.090875e-03	2.962
RNA Polymerase II Transcription	R-HSA-73857	1.082382e-03	2.966
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.158719e-03	2.936
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.269795e-03	2.896
Nuclear Envelope Breakdown	R-HSA-2980766	1.253250e-03	2.902
G2/M Transition	R-HSA-69275	1.342080e-03	2.872
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.469718e-03	2.833
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.469718e-03	2.833
Mitotic Anaphase	R-HSA-68882	1.427383e-03	2.845
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.445694e-03	2.840
Signaling by ALK in cancer	R-HSA-9700206	1.445694e-03	2.840
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.537460e-03	2.813
Mitotic G2-G2/M phases	R-HSA-453274	1.575470e-03	2.803
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.027198e-03	2.693
Mitotic Spindle Checkpoint	R-HSA-69618	2.727953e-03	2.564
Polo-like kinase mediated events	R-HSA-156711	2.730685e-03	2.564
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.024718e-03	2.519
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.972440e-03	2.527
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.972440e-03	2.527
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.057513e-03	2.515
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.235867e-03	2.490
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.322226e-03	2.479
Transcriptional activation of p53 responsive genes	R-HSA-69560	3.473515e-03	2.459
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	3.473515e-03	2.459
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.618336e-03	2.441
RAF activation	R-HSA-5673000	3.630474e-03	2.440
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.329523e-03	2.364
AURKA Activation by TPX2	R-HSA-8854518	4.383383e-03	2.358
MITF-M-dependent gene expression	R-HSA-9856651	4.669913e-03	2.331
SWI/SNF chromatin remodelers	R-HSA-9932451	4.950590e-03	2.305
ATP-dependent chromatin remodelers	R-HSA-9932444	4.950590e-03	2.305
Transcriptional regulation by RUNX1	R-HSA-8878171	4.883600e-03	2.311
Cell Cycle Checkpoints	R-HSA-69620	4.941788e-03	2.306
AKT phosphorylates targets in the cytosol	R-HSA-198323	6.307534e-03	2.200
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.968374e-03	2.157
Signaling by NTRK1 (TRKA)	R-HSA-187037	7.039182e-03	2.152
Transport of the SLBP independent Mature mRNA	R-HSA-159227	7.298087e-03	2.137
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	7.464576e-03	2.127
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	8.139829e-03	2.089
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	8.046558e-03	2.094
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.348355e-03	2.078
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	8.348355e-03	2.078
Amplification of signal from the kinetochores	R-HSA-141424	8.714622e-03	2.060
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	8.714622e-03	2.060
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	8.348355e-03	2.078
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	9.380261e-03	2.028
Depolymerization of the Nuclear Lamina	R-HSA-4419969	9.806949e-03	2.008
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.004106e-02	1.998
HATs acetylate histones	R-HSA-3214847	1.004334e-02	1.998
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.082422e-02	1.966
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.327271e-02	1.877
Heme signaling	R-HSA-9707616	1.367979e-02	1.864
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.484435e-02	1.828
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.484435e-02	1.828
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.403731e-02	1.853
MTOR signalling	R-HSA-165159	1.451366e-02	1.838
Transcriptional Regulation by MECP2	R-HSA-8986944	1.535712e-02	1.814
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.573087e-02	1.803
Oncogenic MAPK signaling	R-HSA-6802957	1.587483e-02	1.799
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.705793e-02	1.768
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.785595e-02	1.748
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.903047e-02	1.721
MECP2 regulates transcription factors	R-HSA-9022707	1.959196e-02	1.708
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.959196e-02	1.708
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.959196e-02	1.708
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.969733e-02	1.706
Disorders of Developmental Biology	R-HSA-9675151	2.128986e-02	1.672
Metabolism of RNA	R-HSA-8953854	2.017255e-02	1.695
Transcriptional Regulation by E2F6	R-HSA-8953750	2.060772e-02	1.686
Signaling by NTRKs	R-HSA-166520	2.133506e-02	1.671
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.209010e-02	1.656
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.260982e-02	1.646
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.370841e-02	1.625
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.370841e-02	1.625
mRNA Splicing - Minor Pathway	R-HSA-72165	2.380906e-02	1.623
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.591836e-02	1.586
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.529053e-02	1.597
Signaling by MRAS-complex mutants	R-HSA-9660537	2.654392e-02	1.576
Formation of annular gap junctions	R-HSA-196025	2.654392e-02	1.576
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.654392e-02	1.576
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.934836e-02	1.532
NGF-stimulated transcription	R-HSA-9031628	2.981427e-02	1.526
Inactivation of CDC42 and RAC1	R-HSA-428543	3.479969e-02	1.458
Gap junction degradation	R-HSA-190873	3.479969e-02	1.458
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.223809e-02	1.492
Unwinding of DNA	R-HSA-176974	3.479969e-02	1.458
Sensory processing of sound	R-HSA-9659379	3.465756e-02	1.460
S Phase	R-HSA-69242	3.495699e-02	1.456
Deadenylation of mRNA	R-HSA-429947	3.495754e-02	1.456
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.499610e-02	1.456
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.632117e-02	1.440
MITF-M-regulated melanocyte development	R-HSA-9730414	3.666470e-02	1.436
Breakdown of the nuclear lamina	R-HSA-352238	3.761574e-02	1.425
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.793209e-02	1.421
Formation of RNA Pol II elongation complex	R-HSA-112382	4.492862e-02	1.347
Generic Transcription Pathway	R-HSA-212436	4.482870e-02	1.348
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.288915e-02	1.368
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.649372e-02	1.333
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.122743e-02	1.290
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.122743e-02	1.290
Signaling downstream of RAS mutants	R-HSA-9649948	5.122743e-02	1.290
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.940209e-02	1.306
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.914769e-02	1.308
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.725042e-02	1.326
Cardiogenesis	R-HSA-9733709	4.745570e-02	1.324
Epigenetic regulation of gene expression	R-HSA-212165	4.984351e-02	1.302
Signaling by RAS mutants	R-HSA-6802949	5.122743e-02	1.290
Nuclear RNA decay	R-HSA-9930044	4.745570e-02	1.324
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.857983e-02	1.314
Regulation of CDH19 Expression and Function	R-HSA-9764302	4.857983e-02	1.314
Kinesins	R-HSA-983189	4.735010e-02	1.325
Regulation of PTEN gene transcription	R-HSA-8943724	4.735010e-02	1.325
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.745570e-02	1.324
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	5.307560e-02	1.275
Separation of Sister Chromatids	R-HSA-2467813	5.349005e-02	1.272
Differentiation of T cells	R-HSA-9945266	5.443053e-02	1.264
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	5.443053e-02	1.264
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.443053e-02	1.264
Prolonged ERK activation events	R-HSA-169893	5.443053e-02	1.264
LGI-ADAM interactions	R-HSA-5682910	5.529718e-02	1.257
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.264769e-02	1.203
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.264769e-02	1.203
Regulation of cortical dendrite branching	R-HSA-8985801	6.264769e-02	1.203
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.264769e-02	1.203
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.264769e-02	1.203
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.264769e-02	1.203
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.264769e-02	1.203
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.264769e-02	1.203
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.264769e-02	1.203
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.264769e-02	1.203
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.264769e-02	1.203
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.264769e-02	1.203
HIV elongation arrest and recovery	R-HSA-167287	6.021280e-02	1.220
Pausing and recovery of HIV elongation	R-HSA-167290	6.021280e-02	1.220
Nuclear Receptor transcription pathway	R-HSA-383280	5.876183e-02	1.231
Membrane Trafficking	R-HSA-199991	5.744306e-02	1.241
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.629489e-02	1.250
Nuclear import of Rev protein	R-HSA-180746	5.983583e-02	1.223
Transcriptional Regulation by VENTX	R-HSA-8853884	5.844831e-02	1.233
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.418449e-02	1.193
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	6.418449e-02	1.193
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	6.418449e-02	1.193
NRAGE signals death through JNK	R-HSA-193648	6.459494e-02	1.190
Signaling by RAF1 mutants	R-HSA-9656223	6.463606e-02	1.190
Activation of RAC1	R-HSA-428540	6.752189e-02	1.171
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.752189e-02	1.171
mTORC1-mediated signalling	R-HSA-166208	6.750319e-02	1.171
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.750319e-02	1.171
Deubiquitination	R-HSA-5688426	7.416289e-02	1.130
Signaling by Hippo	R-HSA-2028269	7.485299e-02	1.126
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.752189e-02	1.171
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.750319e-02	1.171
Activation of the pre-replicative complex	R-HSA-68962	7.617206e-02	1.118
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	7.617206e-02	1.118
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	9.175718e-02	1.037
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	9.175718e-02	1.037
MET interacts with TNS proteins	R-HSA-8875513	9.175718e-02	1.037
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	9.175718e-02	1.037
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	9.175718e-02	1.037
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	9.175718e-02	1.037
Cohesin Loading onto Chromatin	R-HSA-2470946	8.216171e-02	1.085
RUNX3 regulates p14-ARF	R-HSA-8951936	8.102088e-02	1.091
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	8.102088e-02	1.091
Disorders of Nervous System Development	R-HSA-9697154	8.102088e-02	1.091
Pervasive developmental disorders	R-HSA-9005895	8.102088e-02	1.091
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.689816e-02	1.061
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	8.499544e-02	1.071
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	8.499544e-02	1.071
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.189706e-02	1.087
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.189706e-02	1.087
RUNX3 regulates WNT signaling	R-HSA-8951430	8.216171e-02	1.085
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	8.216171e-02	1.085
Neurodegenerative Diseases	R-HSA-8863678	8.689816e-02	1.061
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	8.689816e-02	1.061
ISG15 antiviral mechanism	R-HSA-1169408	8.365746e-02	1.077
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	9.018988e-02	1.045
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.727401e-02	1.059
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	8.560248e-02	1.068
Mitotic Prophase	R-HSA-68875	9.258825e-02	1.033
IRE1alpha activates chaperones	R-HSA-381070	9.388594e-02	1.027
Diseases of mitotic cell cycle	R-HSA-9675126	9.437685e-02	1.025
G0 and Early G1	R-HSA-1538133	9.437685e-02	1.025
Frs2-mediated activation	R-HSA-170968	9.574171e-02	1.019
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	9.574171e-02	1.019
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	9.610331e-02	1.017
Loss of Function of TP53 in Cancer	R-HSA-9723907	9.610331e-02	1.017
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.610331e-02	1.017
TGFBR3 expression	R-HSA-9839394	9.762581e-02	1.010
Sema4D in semaphorin signaling	R-HSA-400685	9.762581e-02	1.010
Signal Transduction	R-HSA-162582	9.867994e-02	1.006
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	9.886600e-02	1.005
NS1 Mediated Effects on Host Pathways	R-HSA-168276	9.894922e-02	1.005
Type I hemidesmosome assembly	R-HSA-446107	1.018300e-01	0.992
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.018300e-01	0.992
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.231586e-01	0.910
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.116188e-01	0.952
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.090218e-01	0.962
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	1.090218e-01	0.962
Interaction between L1 and Ankyrins	R-HSA-445095	1.210667e-01	0.917
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.210667e-01	0.917
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.210667e-01	0.917
IPs transport between nucleus and cytosol	R-HSA-1855170	1.043091e-01	0.982
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.081700e-01	0.966
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.178452e-01	0.929
Regulation of endogenous retroelements	R-HSA-9842860	1.157757e-01	0.936
GP1b-IX-V activation signalling	R-HSA-430116	1.231586e-01	0.910
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	1.116188e-01	0.952
Circadian clock	R-HSA-9909396	1.211754e-01	0.917
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.090218e-01	0.962
Calcineurin activates NFAT	R-HSA-2025928	1.231586e-01	0.910
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.043091e-01	0.982
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	1.035667e-01	0.985
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.032871e-01	0.986
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.081700e-01	0.966
Golgi-to-ER retrograde transport	R-HSA-8856688	1.211754e-01	0.917
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.147819e-01	0.940
Activation of ATR in response to replication stress	R-HSA-176187	1.043091e-01	0.982
Interactions of Rev with host cellular proteins	R-HSA-177243	1.081700e-01	0.966
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.193216e-01	0.923
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.239303e-01	0.907
Regulation of gap junction activity	R-HSA-191650	1.239303e-01	0.907
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.239303e-01	0.907
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.239303e-01	0.907
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.239303e-01	0.907
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.239303e-01	0.907
Signaling by MAP2K mutants	R-HSA-9652169	1.239303e-01	0.907
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.239303e-01	0.907
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	1.239303e-01	0.907
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.262581e-01	0.899
MAP2K and MAPK activation	R-HSA-5674135	1.279656e-01	0.893
DCC mediated attractive signaling	R-HSA-418885	1.285757e-01	0.891
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	1.285757e-01	0.891
Cell-extracellular matrix interactions	R-HSA-446353	1.285757e-01	0.891
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.330369e-01	0.876
Diseases of Telomere Maintenance	R-HSA-9673013	1.829759e-01	0.738
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.829759e-01	0.738
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.829759e-01	0.738
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.829759e-01	0.738
Drug-mediated inhibition of MET activation	R-HSA-9734091	1.829759e-01	0.738
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.829759e-01	0.738
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-9036092	1.829759e-01	0.738
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.829759e-01	0.738
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.829759e-01	0.738
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.829759e-01	0.738
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	2.615039e-01	0.583
Interactions of Tat with host cellular proteins	R-HSA-176034	2.615039e-01	0.583
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.615039e-01	0.583
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.615039e-01	0.583
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.615039e-01	0.583
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.615039e-01	0.583
Defective VWF binding to collagen type I	R-HSA-9845622	2.615039e-01	0.583
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.615039e-01	0.583
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	1.583101e-01	0.800
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.583101e-01	0.800
IRS activation	R-HSA-74713	1.583101e-01	0.800
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.583101e-01	0.800
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.941761e-01	0.712
Phosphorylation of Emi1	R-HSA-176417	1.941761e-01	0.712
PDE3B signalling	R-HSA-165160	1.941761e-01	0.712
PKB-mediated events	R-HSA-109703	1.941761e-01	0.712
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	1.941761e-01	0.712
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.324884e-01	0.478
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.324884e-01	0.478
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	3.324884e-01	0.478
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.324884e-01	0.478
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	3.324884e-01	0.478
MET activates RAP1 and RAC1	R-HSA-8875555	1.459391e-01	0.836
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.459391e-01	0.836
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.309254e-01	0.637
G2/M DNA replication checkpoint	R-HSA-69478	2.309254e-01	0.637
ChREBP activates metabolic gene expression	R-HSA-163765	1.699599e-01	0.770
Presynaptic depolarization and calcium channel opening	R-HSA-112308	1.699599e-01	0.770
Phosphorylation of the APC/C	R-HSA-176412	1.465276e-01	0.834
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.950111e-01	0.710
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	2.680574e-01	0.572
TRIF-mediated programmed cell death	R-HSA-2562578	2.680574e-01	0.572
SOS-mediated signalling	R-HSA-112412	2.680574e-01	0.572
Invadopodia formation	R-HSA-8941237	3.966536e-01	0.402
MET activates PTPN11	R-HSA-8865999	3.966536e-01	0.402
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.411260e-01	0.850
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.051595e-01	0.515
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.051595e-01	0.515
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.567135e-01	0.805
Ephrin signaling	R-HSA-3928664	2.054208e-01	0.687
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.470071e-01	0.833
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.264051e-01	0.645
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.743555e-01	0.562
ARMS-mediated activation	R-HSA-170984	3.418945e-01	0.466
ALK mutants bind TKIs	R-HSA-9700645	3.418945e-01	0.466
TNFR1-mediated ceramide production	R-HSA-5626978	4.546543e-01	0.342
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.546543e-01	0.342
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.546543e-01	0.342
Negative regulation of MET activity	R-HSA-6807004	2.479010e-01	0.606
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.479010e-01	0.606
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.698109e-01	0.569
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.779906e-01	0.423
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.779906e-01	0.423
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.880665e-01	0.726
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.435437e-01	0.613
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.211979e-01	0.655
HIV Transcription Elongation	R-HSA-167169	2.018237e-01	0.695
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.018237e-01	0.695
Telomere Extension By Telomerase	R-HSA-171319	2.622789e-01	0.581
Phase 0 - rapid depolarisation	R-HSA-5576892	2.622789e-01	0.581
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.562674e-01	0.448
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	4.132313e-01	0.384
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.132313e-01	0.384
Signaling by APC mutants	R-HSA-4839744	4.132313e-01	0.384
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.132313e-01	0.384
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.132313e-01	0.384
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.132313e-01	0.384
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.070824e-01	0.295
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.070824e-01	0.295
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.070824e-01	0.295
XBP1(S) activates chaperone genes	R-HSA-381038	1.713804e-01	0.766
MET promotes cell motility	R-HSA-8875878	3.049527e-01	0.516
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.474476e-01	0.349
ERKs are inactivated	R-HSA-202670	4.474476e-01	0.349
Signaling by GSK3beta mutants	R-HSA-5339716	4.474476e-01	0.349
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.538845e-01	0.595
FOXO-mediated transcription of cell death genes	R-HSA-9614657	4.103376e-01	0.387
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	3.823754e-01	0.418
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.808255e-01	0.552
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.368629e-01	0.360
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	4.805109e-01	0.318
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.805109e-01	0.318
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.805109e-01	0.318
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.805109e-01	0.318
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.805109e-01	0.318
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.805109e-01	0.318
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.805109e-01	0.318
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.805109e-01	0.318
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.544730e-01	0.256
Signaling by MAPK mutants	R-HSA-9652817	5.544730e-01	0.256
EPHA-mediated growth cone collapse	R-HSA-3928663	4.272855e-01	0.369
Co-inhibition by CTLA4	R-HSA-389513	4.629243e-01	0.334
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.629243e-01	0.334
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.629243e-01	0.334
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.629243e-01	0.334
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.629243e-01	0.334
Transcription of the HIV genome	R-HSA-167172	3.626123e-01	0.441
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.494352e-01	0.347
Formation of the Early Elongation Complex	R-HSA-113418	4.494352e-01	0.347
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	5.123267e-01	0.290
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.199512e-01	0.377
Late endosomal microautophagy	R-HSA-9615710	4.713044e-01	0.327
Nucleosome assembly	R-HSA-774815	4.461737e-01	0.350
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.461737e-01	0.350
Translation initiation complex formation	R-HSA-72649	4.361505e-01	0.360
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.133582e-01	0.290
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	5.133582e-01	0.290
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.973099e-01	0.224
Erythropoietin activates STAT5	R-HSA-9027283	5.973099e-01	0.224
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.973099e-01	0.224
Defective CYP11A1 causes AICSR	R-HSA-5579026	5.973099e-01	0.224
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.973099e-01	0.224
Ribosomal scanning and start codon recognition	R-HSA-72702	4.683205e-01	0.329
FGFR2 alternative splicing	R-HSA-6803529	5.376099e-01	0.270
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.145725e-01	0.289
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	5.719773e-01	0.243
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.719773e-01	0.243
Erythropoietin activates RAS	R-HSA-9027284	5.719773e-01	0.243
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.719773e-01	0.243
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.719773e-01	0.243
Beta-catenin phosphorylation cascade	R-HSA-196299	5.719773e-01	0.243
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	5.719773e-01	0.243
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	5.305961e-01	0.275
Orc1 removal from chromatin	R-HSA-68949	5.645777e-01	0.248
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	5.688417e-01	0.245
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.360303e-01	0.197
MET activates PI3K/AKT signaling	R-HSA-8851907	6.360303e-01	0.197
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.360303e-01	0.197
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	6.360303e-01	0.197
DAG1 core M1 glycosylations	R-HSA-8932506	6.360303e-01	0.197
Recycling of eIF2:GDP	R-HSA-72731	6.360303e-01	0.197
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.360303e-01	0.197
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.941406e-01	0.226
Tight junction interactions	R-HSA-420029	6.059896e-01	0.218
MET activates PTK2 signaling	R-HSA-8874081	6.272320e-01	0.203
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.311287e-01	0.200
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.359709e-01	0.197
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.359709e-01	0.197
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.517090e-01	0.186
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.710296e-01	0.173
DAG1 core M2 glycosylations	R-HSA-8932504	6.710296e-01	0.173
MET receptor recycling	R-HSA-8875656	6.710296e-01	0.173
Activation of AMPK downstream of NMDARs	R-HSA-9619483	6.673007e-01	0.176
Regulation of TP53 Degradation	R-HSA-6804757	2.706296e-01	0.568
Transcriptional regulation by RUNX3	R-HSA-8878159	1.388929e-01	0.857
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.054208e-01	0.687
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.145725e-01	0.289
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.145725e-01	0.289
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.920399e-01	0.535
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.581491e-01	0.588
Signaling by MET	R-HSA-6806834	5.302621e-01	0.276
Chromosome Maintenance	R-HSA-73886	6.059468e-01	0.218
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.689394e-01	0.245
EPH-Ephrin signaling	R-HSA-2682334	3.382214e-01	0.471
VxPx cargo-targeting to cilium	R-HSA-5620916	4.629243e-01	0.334
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.410645e-01	0.618
Cellular response to heat stress	R-HSA-3371556	4.972501e-01	0.303
Extension of Telomeres	R-HSA-180786	6.693901e-01	0.174
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.208889e-01	0.656
Transcriptional regulation of testis differentiation	R-HSA-9690406	3.562674e-01	0.448
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.809941e-01	0.318
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.934350e-01	0.532
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.360303e-01	0.197
Signaling by ERBB2	R-HSA-1227986	3.819602e-01	0.418
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.061914e-01	0.514
Aggrephagy	R-HSA-9646399	5.145725e-01	0.289
Repression of WNT target genes	R-HSA-4641265	2.208889e-01	0.656
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.567135e-01	0.805
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.006370e-01	0.522
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.830554e-01	0.234
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.101360e-01	0.677
EPHB-mediated forward signaling	R-HSA-3928662	4.285737e-01	0.368
DNA Replication Pre-Initiation	R-HSA-69002	4.499018e-01	0.347
RNA Polymerase III Transcription	R-HSA-74158	6.311287e-01	0.200
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	2.473983e-01	0.607
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.054208e-01	0.687
Meiotic synapsis	R-HSA-1221632	4.199512e-01	0.377
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.000283e-01	0.301
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.713804e-01	0.766
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.261398e-01	0.203
Estrogen-dependent gene expression	R-HSA-9018519	1.508418e-01	0.821
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.583101e-01	0.800
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.699599e-01	0.770
Activated NTRK3 signals through PI3K	R-HSA-9603381	2.680574e-01	0.572
Regulation of CDH11 function	R-HSA-9762292	3.779906e-01	0.423
PI3K/AKT activation	R-HSA-198203	3.779906e-01	0.423
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.132313e-01	0.384
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	5.544730e-01	0.256
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.272855e-01	0.369
DNA Double Strand Break Response	R-HSA-5693606	3.486042e-01	0.458
Downregulation of ERBB2 signaling	R-HSA-8863795	1.608456e-01	0.794
Nucleotide Excision Repair	R-HSA-5696398	5.181723e-01	0.286
Assembly of the pre-replicative complex	R-HSA-68867	3.500823e-01	0.456
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.801549e-01	0.553
DNA Double-Strand Break Repair	R-HSA-5693532	4.628024e-01	0.335
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.941761e-01	0.712
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.473983e-01	0.607
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	3.418945e-01	0.466
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.070824e-01	0.295
Ligand-receptor interactions	R-HSA-5632681	5.544730e-01	0.256
DARPP-32 events	R-HSA-180024	4.713044e-01	0.327
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	5.133582e-01	0.290
Regulation of CDH1 Function	R-HSA-9764561	6.411356e-01	0.193
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	6.710296e-01	0.173
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.710296e-01	0.173
Clathrin-mediated endocytosis	R-HSA-8856828	1.461364e-01	0.835
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.550003e-01	0.450
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.479010e-01	0.606
Long-term potentiation	R-HSA-9620244	3.823754e-01	0.418
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	6.114842e-01	0.214
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.476714e-01	0.189
Homology Directed Repair	R-HSA-5693538	5.739969e-01	0.241
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.298940e-01	0.276
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.997490e-01	0.222
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.251848e-01	0.647
Switching of origins to a post-replicative state	R-HSA-69052	2.023134e-01	0.694
Resolution of D-Loop Structures	R-HSA-5693537	3.792769e-01	0.421
TNF signaling	R-HSA-75893	2.040867e-01	0.690
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.583101e-01	0.800
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.950111e-01	0.710
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.608456e-01	0.794
Phase 2 - plateau phase	R-HSA-5576893	3.562674e-01	0.448
Formation of the posterior neural plate	R-HSA-9832991	4.132313e-01	0.384
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.070824e-01	0.295
Activation of AKT2	R-HSA-165158	5.070824e-01	0.295
Late Phase of HIV Life Cycle	R-HSA-162599	1.985069e-01	0.702
Chylomicron remodeling	R-HSA-8963901	5.123267e-01	0.290
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.313176e-01	0.480
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.973099e-01	0.224
RAF-independent MAPK1/3 activation	R-HSA-112409	5.376099e-01	0.270
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.550353e-01	0.256
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.550353e-01	0.256
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.688417e-01	0.245
PTK6 Expression	R-HSA-8849473	6.360303e-01	0.197
Cilium Assembly	R-HSA-5617833	1.674131e-01	0.776
Signaling by ROBO receptors	R-HSA-376176	3.199861e-01	0.495
PIP3 activates AKT signaling	R-HSA-1257604	2.501656e-01	0.602
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.470071e-01	0.833
Recycling pathway of L1	R-HSA-437239	1.973006e-01	0.705
UCH proteinases	R-HSA-5689603	4.752976e-01	0.323
Regulation of TNFR1 signaling	R-HSA-5357905	1.847995e-01	0.733
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.919499e-01	0.717
Neurexins and neuroligins	R-HSA-6794361	5.645777e-01	0.248
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.208889e-01	0.656
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.474476e-01	0.349
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.123267e-01	0.290
PTEN Regulation	R-HSA-6807070	4.103005e-01	0.387
Inhibition of nitric oxide production	R-HSA-9636249	3.966536e-01	0.402
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.418945e-01	0.466
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	3.779906e-01	0.423
HDACs deacetylate histones	R-HSA-3214815	3.074811e-01	0.512
MET Receptor Activation	R-HSA-6806942	5.973099e-01	0.224
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	5.376099e-01	0.270
p38MAPK events	R-HSA-171007	5.719773e-01	0.243
Transcriptional regulation by small RNAs	R-HSA-5578749	5.589314e-01	0.253
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.511582e-01	0.186
ESR-mediated signaling	R-HSA-8939211	6.027519e-01	0.220
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.200056e-01	0.377
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.583101e-01	0.800
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.309254e-01	0.637
Neurofascin interactions	R-HSA-447043	2.309254e-01	0.637
Vasopressin-like receptors	R-HSA-388479	4.546543e-01	0.342
Ovarian tumor domain proteases	R-HSA-5689896	1.617798e-01	0.791
ERK/MAPK targets	R-HSA-198753	2.698109e-01	0.569
Myogenesis	R-HSA-525793	4.049115e-01	0.393
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.329934e-01	0.273
Regulated Necrosis	R-HSA-5218859	6.463707e-01	0.190
Signaling by SCF-KIT	R-HSA-1433557	5.862226e-01	0.232
Signalling to ERKs	R-HSA-187687	1.372945e-01	0.862
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	2.680574e-01	0.572
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.873713e-01	0.412
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.873713e-01	0.412
Cyclin E associated events during G1/S transition	R-HSA-69202	3.907910e-01	0.408
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.538845e-01	0.595
Unfolded Protein Response (UPR)	R-HSA-381119	1.704250e-01	0.768
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.261398e-01	0.203
G2/M Checkpoints	R-HSA-69481	2.741838e-01	0.562
Intracellular signaling by second messengers	R-HSA-9006925	4.283461e-01	0.368
Cell-cell junction organization	R-HSA-421270	6.312541e-01	0.200
Adherens junctions interactions	R-HSA-418990	6.131188e-01	0.212
Cell junction organization	R-HSA-446728	4.596408e-01	0.338
FGFR1 mutant receptor activation	R-HSA-1839124	5.550353e-01	0.256
Signaling by WNT	R-HSA-195721	6.722086e-01	0.172
Diseases of programmed cell death	R-HSA-9645723	3.919538e-01	0.407
Axon guidance	R-HSA-422475	1.960052e-01	0.708
Organelle biogenesis and maintenance	R-HSA-1852241	2.870121e-01	0.542
TCF dependent signaling in response to WNT	R-HSA-201681	3.909306e-01	0.408
Formation of editosomes by ADAR proteins	R-HSA-77042	1.829759e-01	0.738
mRNA Editing: A to I Conversion	R-HSA-75064	3.324884e-01	0.478
C6 deamination of adenosine	R-HSA-75102	3.324884e-01	0.478
Cation-coupled Chloride cotransporters	R-HSA-426117	2.680574e-01	0.572
MET activates STAT3	R-HSA-8875791	3.966536e-01	0.402
Regulation of KIT signaling	R-HSA-1433559	2.743555e-01	0.562
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	4.546543e-01	0.342
Deadenylation-dependent mRNA decay	R-HSA-429914	1.464789e-01	0.834
Bicarbonate transporters	R-HSA-425381	4.132313e-01	0.384
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.070824e-01	0.295
Reelin signalling pathway	R-HSA-8866376	5.070824e-01	0.295
Metabolism of non-coding RNA	R-HSA-194441	2.410645e-01	0.618
snRNP Assembly	R-HSA-191859	2.410645e-01	0.618
Signaling by AMER1 mutants	R-HSA-4839748	4.474476e-01	0.349
Signaling by AXIN mutants	R-HSA-4839735	4.474476e-01	0.349
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.911772e-01	0.536
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.103376e-01	0.387
Pentose phosphate pathway disease	R-HSA-6791465	5.544730e-01	0.256
CDC6 association with the ORC:origin complex	R-HSA-68689	5.544730e-01	0.256
Viral Messenger RNA Synthesis	R-HSA-168325	3.970390e-01	0.401
Ub-specific processing proteases	R-HSA-5689880	3.055959e-01	0.515
COPI-mediated anterograde transport	R-HSA-6807878	3.981035e-01	0.400
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.133582e-01	0.290
G2/M DNA damage checkpoint	R-HSA-69473	4.472752e-01	0.349
Notch-HLH transcription pathway	R-HSA-350054	5.376099e-01	0.270
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.719773e-01	0.243
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.611549e-01	0.251
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.748424e-01	0.240
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	5.997490e-01	0.222
Electron transport from NADPH to Ferredoxin	R-HSA-2395516	6.360303e-01	0.197
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.191256e-01	0.208
Adrenoceptors	R-HSA-390696	6.710296e-01	0.173
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.710296e-01	0.173
Regulation by c-FLIP	R-HSA-3371378	6.710296e-01	0.173
Sodium/Proton exchangers	R-HSA-425986	6.710296e-01	0.173
Cell-Cell communication	R-HSA-1500931	4.510013e-01	0.346
VEGFA-VEGFR2 Pathway	R-HSA-4420097	6.510808e-01	0.186
Nervous system development	R-HSA-9675108	2.708273e-01	0.567
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.719742e-01	0.765
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.780362e-01	0.321
Negative regulation of MAPK pathway	R-HSA-5675221	2.304291e-01	0.637
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.648273e-01	0.783
HIV Life Cycle	R-HSA-162587	1.785060e-01	0.748
ER to Golgi Anterograde Transport	R-HSA-199977	5.006577e-01	0.300
G1/S Transition	R-HSA-69206	1.823912e-01	0.739
Vesicle-mediated transport	R-HSA-5653656	5.496680e-01	0.260
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	2.460238e-01	0.609
Regulation of CDH11 gene transcription	R-HSA-9762293	3.418945e-01	0.466
TRP channels	R-HSA-3295583	2.251848e-01	0.647
Signal attenuation	R-HSA-74749	3.779906e-01	0.423
Receptor Mediated Mitophagy	R-HSA-8934903	3.779906e-01	0.423
Rap1 signalling	R-HSA-392517	4.368629e-01	0.360
Rab regulation of trafficking	R-HSA-9007101	3.488226e-01	0.457
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.593705e-01	0.444
Apoptosis induced DNA fragmentation	R-HSA-140342	1.459391e-01	0.836
Negative regulation of FLT3	R-HSA-9706369	3.289409e-01	0.483
Autophagy	R-HSA-9612973	5.878333e-01	0.231
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.546543e-01	0.342
G alpha (12/13) signalling events	R-HSA-416482	1.673610e-01	0.776
Signaling by LTK	R-HSA-9842663	4.805109e-01	0.318
Release of Hh-Np from the secreting cell	R-HSA-5362798	5.544730e-01	0.256
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.544730e-01	0.256
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	5.376099e-01	0.270
HIV Infection	R-HSA-162906	6.039321e-01	0.219
Cellular Senescence	R-HSA-2559583	2.866949e-01	0.543
L1CAM interactions	R-HSA-373760	3.383372e-01	0.471
Nephrin family interactions	R-HSA-373753	4.629243e-01	0.334
Signaling by NOTCH1	R-HSA-1980143	6.132380e-01	0.212
Post NMDA receptor activation events	R-HSA-438064	6.329628e-01	0.199
PI5P Regulates TP53 Acetylation	R-HSA-6811555	2.473983e-01	0.607
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.519150e-01	0.454
Macroautophagy	R-HSA-1632852	4.304331e-01	0.366
Selective autophagy	R-HSA-9663891	6.449230e-01	0.190
Synthesis of DNA	R-HSA-69239	5.415111e-01	0.266
Death Receptor Signaling	R-HSA-73887	2.204978e-01	0.657
Semaphorin interactions	R-HSA-373755	4.271964e-01	0.369
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.008611e-01	0.697
TBC/RABGAPs	R-HSA-8854214	4.108885e-01	0.386
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.038715e-01	0.691
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.724171e-01	0.429
Netrin-1 signaling	R-HSA-373752	2.756242e-01	0.560
HDMs demethylate histones	R-HSA-3214842	6.059896e-01	0.218
Signaling by TGFBR3	R-HSA-9839373	3.069222e-01	0.513
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.743555e-01	0.562
Sensory perception of sour taste	R-HSA-9729555	4.546543e-01	0.342
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	3.779906e-01	0.423
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.562674e-01	0.448
Signalling to p38 via RIT and RIN	R-HSA-187706	5.544730e-01	0.256
Retrograde neurotrophin signalling	R-HSA-177504	5.428294e-01	0.265
Gap junction trafficking and regulation	R-HSA-157858	5.151199e-01	0.288
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	5.839572e-01	0.234
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.360303e-01	0.197
Ca2+ activated K+ channels	R-HSA-1296052	6.360303e-01	0.197
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.511582e-01	0.186
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	6.710296e-01	0.173
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	6.710296e-01	0.173
Dimerization of procaspase-8	R-HSA-69416	6.710296e-01	0.173
TGFBR3 PTM regulation	R-HSA-9839383	6.710296e-01	0.173
Nuclear signaling by ERBB4	R-HSA-1251985	3.399826e-01	0.469
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.928419e-01	0.307
Oncogene Induced Senescence	R-HSA-2559585	6.129084e-01	0.213
Programmed Cell Death	R-HSA-5357801	2.719501e-01	0.566
Downstream signal transduction	R-HSA-186763	5.140022e-01	0.289
MHC class II antigen presentation	R-HSA-2132295	4.127581e-01	0.384
Mitochondrial biogenesis	R-HSA-1592230	6.712202e-01	0.173
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.511582e-01	0.186
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.617798e-01	0.791
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.459391e-01	0.836
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.309254e-01	0.637
Suppression of apoptosis	R-HSA-9635465	4.132313e-01	0.384
tRNA processing in the nucleus	R-HSA-6784531	4.121250e-01	0.385
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	4.115740e-01	0.386
Signaling by EGFR	R-HSA-177929	4.683205e-01	0.329
Spry regulation of FGF signaling	R-HSA-1295596	5.719773e-01	0.243
Class I MHC mediated antigen processing & presentation	R-HSA-983169	4.471917e-01	0.350
Activation of BH3-only proteins	R-HSA-114452	3.006370e-01	0.522
Specification of primordial germ cells	R-HSA-9827857	3.834383e-01	0.416
Signaling by ALK	R-HSA-201556	1.880665e-01	0.726
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.324884e-01	0.478
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.680574e-01	0.572
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	2.208889e-01	0.656
Dopamine receptors	R-HSA-390651	4.546543e-01	0.342
G1/S-Specific Transcription	R-HSA-69205	1.493005e-01	0.826
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.070824e-01	0.295
NrCAM interactions	R-HSA-447038	5.070824e-01	0.295
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.040867e-01	0.690
FLT3 signaling in disease	R-HSA-9682385	2.706296e-01	0.568
Trafficking of AMPA receptors	R-HSA-399719	3.201415e-01	0.495
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	5.544730e-01	0.256
Formation of axial mesoderm	R-HSA-9796292	5.123267e-01	0.290
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	4.713044e-01	0.327
NADPH regeneration	R-HSA-389542	5.973099e-01	0.224
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.166925e-01	0.287
MAP kinase activation	R-HSA-450294	5.463546e-01	0.263
Netrin mediated repulsion signals	R-HSA-418886	6.360303e-01	0.197
Regulation of PTEN localization	R-HSA-8948747	6.360303e-01	0.197
Alpha-defensins	R-HSA-1462054	6.710296e-01	0.173
Signaling by TGFB family members	R-HSA-9006936	1.986783e-01	0.702
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.943706e-01	0.531
Inositol phosphate metabolism	R-HSA-1483249	5.979825e-01	0.223
PI Metabolism	R-HSA-1483255	3.574686e-01	0.447
Zygotic genome activation (ZGA)	R-HSA-9819196	4.884447e-01	0.311
Interleukin-17 signaling	R-HSA-448424	6.724370e-01	0.172
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.108885e-01	0.386
Activation of SMO	R-HSA-5635838	5.997490e-01	0.222
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.724370e-01	0.172
RUNX2 regulates bone development	R-HSA-8941326	2.706296e-01	0.568
Apoptosis	R-HSA-109581	2.127240e-01	0.672
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.911772e-01	0.536
Transcriptional regulation by RUNX2	R-HSA-8878166	4.751833e-01	0.323
FLT3 Signaling	R-HSA-9607240	5.329934e-01	0.273
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.494352e-01	0.347
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	2.698109e-01	0.569
DNA strand elongation	R-HSA-69190	3.397862e-01	0.469
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.069222e-01	0.513
OAS antiviral response	R-HSA-8983711	4.805109e-01	0.318
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	5.544730e-01	0.256
Lipid particle organization	R-HSA-8964572	5.973099e-01	0.224
Nef and signal transduction	R-HSA-164944	5.973099e-01	0.224
Formation of the anterior neural plate	R-HSA-9823739	5.719773e-01	0.243
Induction of Cell-Cell Fusion	R-HSA-9733458	5.997490e-01	0.222
CHL1 interactions	R-HSA-447041	6.360303e-01	0.197
Downregulation of ERBB4 signaling	R-HSA-1253288	6.710296e-01	0.173
Interleukin-7 signaling	R-HSA-1266695	6.059896e-01	0.218
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	4.271964e-01	0.369
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.658759e-01	0.177
RMTs methylate histone arginines	R-HSA-3214858	4.285737e-01	0.368
Regulation of NPAS4 gene expression	R-HSA-9768759	6.511582e-01	0.186
Gene Silencing by RNA	R-HSA-211000	6.560043e-01	0.183
Signaling by PDGFR in disease	R-HSA-9671555	1.411260e-01	0.850
Physiological factors	R-HSA-5578768	5.428294e-01	0.265
Miscellaneous transport and binding events	R-HSA-5223345	5.748424e-01	0.240
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.997490e-01	0.222
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	6.710296e-01	0.173
Uptake and function of anthrax toxins	R-HSA-5210891	3.834383e-01	0.416
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.360303e-01	0.197
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.261398e-01	0.203
Collagen chain trimerization	R-HSA-8948216	6.487879e-01	0.188
Activated NTRK2 signals through FYN	R-HSA-9032500	6.710296e-01	0.173
Pyroptosis	R-HSA-5620971	4.494352e-01	0.347
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.997490e-01	0.222
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.261398e-01	0.203
RET signaling	R-HSA-8853659	6.311287e-01	0.200
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	6.658759e-01	0.177
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.595157e-01	0.444
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.428294e-01	0.265
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.050817e-01	0.218
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.261398e-01	0.203
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	5.571838e-01	0.254
Signaling by Leptin	R-HSA-2586552	3.779906e-01	0.423
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	6.710296e-01	0.173
p75 NTR receptor-mediated signalling	R-HSA-193704	4.343953e-01	0.362
Interleukin-37 signaling	R-HSA-9008059	1.608456e-01	0.794
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.023134e-01	0.694
Maturation of hRSV A proteins	R-HSA-9828806	6.476714e-01	0.189
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	4.103376e-01	0.387
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	5.376099e-01	0.270
DNA Repair	R-HSA-73894	6.744677e-01	0.171
Signaling by ERBB2 ECD mutants	R-HSA-9665348	6.748244e-01	0.171
RNA Polymerase III Transcription Termination	R-HSA-73980	6.748244e-01	0.171
Chaperone Mediated Autophagy	R-HSA-9613829	6.748244e-01	0.171
Mismatch Repair	R-HSA-5358508	6.748244e-01	0.171
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.748244e-01	0.171
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	6.748244e-01	0.171
Processing of DNA double-strand break ends	R-HSA-5693607	6.758483e-01	0.170
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.818588e-01	0.166
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.818588e-01	0.166
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.823863e-01	0.166
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	6.829745e-01	0.166
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	6.829745e-01	0.166
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	6.829745e-01	0.166
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	6.829745e-01	0.166
Signaling by NOTCH1 in Cancer	R-HSA-2644603	6.829745e-01	0.166
Glycolysis	R-HSA-70171	6.831698e-01	0.165
Regulation of mitotic cell cycle	R-HSA-453276	6.850116e-01	0.164
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.850116e-01	0.164
Hedgehog 'on' state	R-HSA-5632684	6.850116e-01	0.164
Signaling by Erythropoietin	R-HSA-9006335	6.861185e-01	0.164
Impaired BRCA2 binding to RAD51	R-HSA-9709570	6.861185e-01	0.164
Regulation of gene expression in beta cells	R-HSA-210745	6.861185e-01	0.164
Collagen degradation	R-HSA-1442490	6.961896e-01	0.157
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.971668e-01	0.157
Germ layer formation at gastrulation	R-HSA-9754189	6.971668e-01	0.157
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.971668e-01	0.157
Specification of the neural plate border	R-HSA-9834899	6.971668e-01	0.157
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.983152e-01	0.156
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.017803e-01	0.154
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	7.026653e-01	0.153
WNT mediated activation of DVL	R-HSA-201688	7.026653e-01	0.153
MAPK1 (ERK2) activation	R-HSA-112411	7.026653e-01	0.153
CASP8 activity is inhibited	R-HSA-5218900	7.026653e-01	0.153
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.026653e-01	0.153
Lipophagy	R-HSA-9613354	7.026653e-01	0.153
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.026653e-01	0.153
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.026653e-01	0.153
p75NTR regulates axonogenesis	R-HSA-193697	7.026653e-01	0.153
mRNA Editing	R-HSA-75072	7.026653e-01	0.153
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.026653e-01	0.153
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.026653e-01	0.153
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.026653e-01	0.153
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.026653e-01	0.153
Cellular response to mitochondrial stress	R-HSA-9840373	7.026653e-01	0.153
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.034783e-01	0.153
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.038512e-01	0.153
Oxidative Stress Induced Senescence	R-HSA-2559580	7.038512e-01	0.153
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.041278e-01	0.152
DAP12 signaling	R-HSA-2424491	7.041278e-01	0.152
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.090317e-01	0.149
HSF1-dependent transactivation	R-HSA-3371571	7.102028e-01	0.149
Resolution of Abasic Sites (AP sites)	R-HSA-73933	7.136617e-01	0.147
VEGFR2 mediated vascular permeability	R-HSA-5218920	7.136617e-01	0.147
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.182212e-01	0.144
Protein hydroxylation	R-HSA-9629569	7.182212e-01	0.144
Signal transduction by L1	R-HSA-445144	7.182212e-01	0.144
Adipogenesis	R-HSA-9843745	7.210994e-01	0.142
Protein-protein interactions at synapses	R-HSA-6794362	7.211903e-01	0.142
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.213359e-01	0.142
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	7.213359e-01	0.142
Budding and maturation of HIV virion	R-HSA-162588	7.213359e-01	0.142
EGFR downregulation	R-HSA-182971	7.213359e-01	0.142
Evasion by RSV of host interferon responses	R-HSA-9833109	7.213359e-01	0.142
G1/S DNA Damage Checkpoints	R-HSA-69615	7.214984e-01	0.142
Signaling by PTK6	R-HSA-8848021	7.214984e-01	0.142
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	7.214984e-01	0.142
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	7.236633e-01	0.140
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.236906e-01	0.140
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.236906e-01	0.140
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	7.254525e-01	0.139
Signaling by FGFR1 in disease	R-HSA-5655302	7.284275e-01	0.138
MAPK3 (ERK1) activation	R-HSA-110056	7.312604e-01	0.136
Folding of actin by CCT/TriC	R-HSA-390450	7.312604e-01	0.136
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.312604e-01	0.136
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	7.312604e-01	0.136
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	7.312604e-01	0.136
Pexophagy	R-HSA-9664873	7.312604e-01	0.136
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.332379e-01	0.135
Activation of HOX genes during differentiation	R-HSA-5619507	7.332379e-01	0.135
Host Interactions of HIV factors	R-HSA-162909	7.362140e-01	0.133
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.367219e-01	0.133
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.367219e-01	0.133
Amino acids regulate mTORC1	R-HSA-9639288	7.367219e-01	0.133
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	7.377536e-01	0.132
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.380287e-01	0.132
Signalling to RAS	R-HSA-167044	7.380287e-01	0.132
Basigin interactions	R-HSA-210991	7.380287e-01	0.132
Early Phase of HIV Life Cycle	R-HSA-162594	7.380287e-01	0.132
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.425896e-01	0.129
Interleukin-12 signaling	R-HSA-9020591	7.431420e-01	0.129
Interferon Signaling	R-HSA-913531	7.489842e-01	0.126
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.492983e-01	0.125
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.516717e-01	0.124
Signaling by VEGF	R-HSA-194138	7.531396e-01	0.123
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.533950e-01	0.123
Regulation of necroptotic cell death	R-HSA-5675482	7.533950e-01	0.123
Integrin signaling	R-HSA-354192	7.533950e-01	0.123
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.533950e-01	0.123
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.533950e-01	0.123
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.566343e-01	0.121
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.566343e-01	0.121
DAG1 core M3 glycosylations	R-HSA-8932505	7.571070e-01	0.121
Synthesis of PI	R-HSA-1483226	7.571070e-01	0.121
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.571070e-01	0.121
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.571070e-01	0.121
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.571070e-01	0.121
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.571070e-01	0.121
Chylomicron assembly	R-HSA-8963888	7.571070e-01	0.121
PECAM1 interactions	R-HSA-210990	7.571070e-01	0.121
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.571070e-01	0.121
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.614229e-01	0.118
Effects of PIP2 hydrolysis	R-HSA-114508	7.682764e-01	0.114
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.682764e-01	0.114
Gap junction trafficking	R-HSA-190828	7.692874e-01	0.114
MyD88 cascade initiated on plasma membrane	R-HSA-975871	7.700760e-01	0.113
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	7.700760e-01	0.113
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	7.700760e-01	0.113
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.730997e-01	0.112
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.730997e-01	0.112
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.740860e-01	0.111
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.804691e-01	0.108
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.804691e-01	0.108
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.804691e-01	0.108
Anchoring fibril formation	R-HSA-2214320	7.804691e-01	0.108
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.804691e-01	0.108
Integration of provirus	R-HSA-162592	7.804691e-01	0.108
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.817865e-01	0.107
Fanconi Anemia Pathway	R-HSA-6783310	7.817865e-01	0.107
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.824166e-01	0.107
NPAS4 regulates expression of target genes	R-HSA-9768919	7.824166e-01	0.107
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	7.824166e-01	0.107
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.824166e-01	0.107
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.824166e-01	0.107
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.824166e-01	0.107
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.824166e-01	0.107
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	7.859865e-01	0.105
MyD88-independent TLR4 cascade	R-HSA-166166	7.859865e-01	0.105
Hedgehog 'off' state	R-HSA-5610787	7.874864e-01	0.104
Regulation of PTEN mRNA translation	R-HSA-8943723	7.904335e-01	0.102
Carnitine shuttle	R-HSA-200425	7.904335e-01	0.102
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.904335e-01	0.102
Growth hormone receptor signaling	R-HSA-982772	7.904335e-01	0.102
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.958361e-01	0.099
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.982773e-01	0.098
Signaling by Nuclear Receptors	R-HSA-9006931	7.991546e-01	0.097
MET activates RAS signaling	R-HSA-8851805	8.015855e-01	0.096
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.015855e-01	0.096
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.015855e-01	0.096
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.015855e-01	0.096
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.015855e-01	0.096
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.015855e-01	0.096
Estrogen biosynthesis	R-HSA-193144	8.015855e-01	0.096
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.015855e-01	0.096
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.039127e-01	0.095
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.055020e-01	0.094
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	8.057277e-01	0.094
TRAF6 mediated NF-kB activation	R-HSA-933542	8.057277e-01	0.094
Plasma lipoprotein assembly	R-HSA-8963898	8.057277e-01	0.094
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.057277e-01	0.094
NoRC negatively regulates rRNA expression	R-HSA-427413	8.077789e-01	0.093
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.077789e-01	0.093
PRC2 methylates histones and DNA	R-HSA-212300	8.085566e-01	0.092
GPVI-mediated activation cascade	R-HSA-114604	8.085566e-01	0.092
Triglyceride catabolism	R-HSA-163560	8.085566e-01	0.092
Co-stimulation by CD28	R-HSA-389356	8.160666e-01	0.088
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.169274e-01	0.088
DNA Replication	R-HSA-69306	8.182013e-01	0.087
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	8.195957e-01	0.086
Formation of the nephric duct	R-HSA-9830364	8.200200e-01	0.086
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.200200e-01	0.086
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.206718e-01	0.086
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	8.206718e-01	0.086
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	8.206718e-01	0.086
Platelet Adhesion to exposed collagen	R-HSA-75892	8.206718e-01	0.086
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	8.206718e-01	0.086
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.206718e-01	0.086
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.206718e-01	0.086
Processing of SMDT1	R-HSA-8949664	8.206718e-01	0.086
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.206718e-01	0.086
Maturation of nucleoprotein	R-HSA-9683610	8.206718e-01	0.086
MAPK family signaling cascades	R-HSA-5683057	8.222761e-01	0.085
IRS-related events triggered by IGF1R	R-HSA-2428928	8.249867e-01	0.084
Ca2+ pathway	R-HSA-4086398	8.257290e-01	0.083
Degradation of CDH1	R-HSA-9766229	8.264628e-01	0.083
Meiosis	R-HSA-1500620	8.277654e-01	0.082
MAPK6/MAPK4 signaling	R-HSA-5687128	8.277654e-01	0.082
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.307568e-01	0.081
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.319938e-01	0.080
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.319938e-01	0.080
Metalloprotease DUBs	R-HSA-5689901	8.333615e-01	0.079
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.333615e-01	0.079
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.333615e-01	0.079
Signaling by PDGF	R-HSA-186797	8.341199e-01	0.079
Signaling by ERBB4	R-HSA-1236394	8.341902e-01	0.079
Signaling by FGFR in disease	R-HSA-1226099	8.341902e-01	0.079
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	8.348929e-01	0.078
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	8.348929e-01	0.078
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	8.348929e-01	0.078
PI3K Cascade	R-HSA-109704	8.363667e-01	0.078
Interferon alpha/beta signaling	R-HSA-909733	8.374674e-01	0.077
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.379231e-01	0.077
cGMP effects	R-HSA-418457	8.379231e-01	0.077
CRMPs in Sema3A signaling	R-HSA-399956	8.379231e-01	0.077
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.379231e-01	0.077
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.379231e-01	0.077
HDL assembly	R-HSA-8963896	8.379231e-01	0.077
Signal regulatory protein family interactions	R-HSA-391160	8.379231e-01	0.077
Zinc transporters	R-HSA-435354	8.379231e-01	0.077
SARS-CoV-1-host interactions	R-HSA-9692914	8.407887e-01	0.075
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.423180e-01	0.075
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.423180e-01	0.075
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.427585e-01	0.074
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.428598e-01	0.074
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.458029e-01	0.073
RNA Polymerase I Transcription Termination	R-HSA-73863	8.458029e-01	0.073
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.458029e-01	0.073
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.458029e-01	0.073
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.458029e-01	0.073
Toll-like Receptor Cascades	R-HSA-168898	8.497627e-01	0.071
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.501198e-01	0.071
Glucose metabolism	R-HSA-70326	8.502683e-01	0.070
Interleukin-12 family signaling	R-HSA-447115	8.505314e-01	0.070
IGF1R signaling cascade	R-HSA-2428924	8.512165e-01	0.070
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.535158e-01	0.069
G beta:gamma signalling through BTK	R-HSA-8964315	8.535158e-01	0.069
RNA Polymerase III Chain Elongation	R-HSA-73780	8.535158e-01	0.069
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.535158e-01	0.069
Telomere C-strand synthesis initiation	R-HSA-174430	8.535158e-01	0.069
Translesion synthesis by REV1	R-HSA-110312	8.535158e-01	0.069
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.535158e-01	0.069
Biotin transport and metabolism	R-HSA-196780	8.535158e-01	0.069
Protein lipoylation	R-HSA-9857492	8.535158e-01	0.069
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.535158e-01	0.069
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.535158e-01	0.069
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	8.535158e-01	0.069
Processive synthesis on the lagging strand	R-HSA-69183	8.535158e-01	0.069
DNA Damage Reversal	R-HSA-73942	8.535158e-01	0.069
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	8.539267e-01	0.069
Stimuli-sensing channels	R-HSA-2672351	8.539267e-01	0.069
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	8.547569e-01	0.068
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.573938e-01	0.067
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.592006e-01	0.066
MyD88 dependent cascade initiated on endosome	R-HSA-975155	8.601646e-01	0.065
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.622628e-01	0.064
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.622628e-01	0.064
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.632737e-01	0.064
RNA Polymerase I Transcription	R-HSA-73864	8.647761e-01	0.063
Translesion synthesis by POLI	R-HSA-5656121	8.676092e-01	0.062
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	8.676092e-01	0.062
Defective GALNT3 causes HFTC	R-HSA-5083625	8.676092e-01	0.062
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.676092e-01	0.062
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.676092e-01	0.062
Killing mechanisms	R-HSA-9664420	8.676092e-01	0.062
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.676092e-01	0.062
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.676092e-01	0.062
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.676092e-01	0.062
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.676092e-01	0.062
Regulation of NF-kappa B signaling	R-HSA-9758274	8.676092e-01	0.062
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.676092e-01	0.062
Signaling by ERBB2 KD Mutants	R-HSA-9664565	8.681827e-01	0.061
mRNA Capping	R-HSA-72086	8.681827e-01	0.061
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.681827e-01	0.061
DNA methylation	R-HSA-5334118	8.681827e-01	0.061
Platelet calcium homeostasis	R-HSA-418360	8.681827e-01	0.061
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.681827e-01	0.061
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.715336e-01	0.060
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.740940e-01	0.058
Signaling by ERBB2 in Cancer	R-HSA-1227990	8.782166e-01	0.056
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.782232e-01	0.056
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.788031e-01	0.056
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.788031e-01	0.056
Signaling by NOTCH3	R-HSA-9012852	8.790287e-01	0.056
Cleavage of the damaged pyrimidine	R-HSA-110329	8.800350e-01	0.056
Depyrimidination	R-HSA-73928	8.800350e-01	0.056
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.803475e-01	0.055
Translesion synthesis by POLK	R-HSA-5655862	8.803475e-01	0.055
Fibronectin matrix formation	R-HSA-1566977	8.803475e-01	0.055
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.803475e-01	0.055
Acetylcholine regulates insulin secretion	R-HSA-399997	8.803475e-01	0.055
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	8.810254e-01	0.055
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.810254e-01	0.055
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.830068e-01	0.054
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	8.839442e-01	0.054
Maternal to zygotic transition (MZT)	R-HSA-9816359	8.839442e-01	0.054
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.862984e-01	0.052
Cargo concentration in the ER	R-HSA-5694530	8.875407e-01	0.052
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.876283e-01	0.052
Response of Mtb to phagocytosis	R-HSA-9637690	8.880320e-01	0.052
PPARA activates gene expression	R-HSA-1989781	8.887429e-01	0.051
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	8.905282e-01	0.050
RAF/MAP kinase cascade	R-HSA-5673001	8.908868e-01	0.050
PI3K events in ERBB2 signaling	R-HSA-1963642	8.918607e-01	0.050
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.918607e-01	0.050
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	8.918607e-01	0.050
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.918607e-01	0.050
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.918607e-01	0.050
Regulation of FZD by ubiquitination	R-HSA-4641263	8.918607e-01	0.050
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.918607e-01	0.050
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.918607e-01	0.050
IRS-mediated signalling	R-HSA-112399	8.931838e-01	0.049
COPII-mediated vesicle transport	R-HSA-204005	8.939138e-01	0.049
DAP12 interactions	R-HSA-2172127	8.955486e-01	0.048
Signaling by WNT in cancer	R-HSA-4791275	8.961989e-01	0.048
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.961989e-01	0.048
Cytoprotection by HMOX1	R-HSA-9707564	8.962736e-01	0.048
Transport to the Golgi and subsequent modification	R-HSA-948021	8.971904e-01	0.047
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.972426e-01	0.047
Collagen formation	R-HSA-1474290	8.995140e-01	0.046
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.998931e-01	0.046
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.022668e-01	0.045
PKA activation	R-HSA-163615	9.022668e-01	0.045
PKA activation in glucagon signalling	R-HSA-164378	9.022668e-01	0.045
Synaptic adhesion-like molecules	R-HSA-8849932	9.022668e-01	0.045
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.022668e-01	0.045
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.022668e-01	0.045
Platelet sensitization by LDL	R-HSA-432142	9.022668e-01	0.045
GAB1 signalosome	R-HSA-180292	9.022668e-01	0.045
Tie2 Signaling	R-HSA-210993	9.022668e-01	0.045
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.042328e-01	0.044
G-protein beta:gamma signalling	R-HSA-397795	9.042328e-01	0.044
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.042328e-01	0.044
Regulation of beta-cell development	R-HSA-186712	9.058638e-01	0.043
Triglyceride metabolism	R-HSA-8979227	9.058638e-01	0.043
Developmental Biology	R-HSA-1266738	9.065710e-01	0.043
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.073695e-01	0.042
Regulation of pyruvate metabolism	R-HSA-9861718	9.092341e-01	0.041
Diseases of DNA repair	R-HSA-9675135	9.092341e-01	0.041
Crosslinking of collagen fibrils	R-HSA-2243919	9.116720e-01	0.040
E2F mediated regulation of DNA replication	R-HSA-113510	9.116720e-01	0.040
Diseases of hemostasis	R-HSA-9671793	9.116720e-01	0.040
Other interleukin signaling	R-HSA-449836	9.116720e-01	0.040
Regulation of signaling by CBL	R-HSA-912631	9.116720e-01	0.040
STING mediated induction of host immune responses	R-HSA-1834941	9.116720e-01	0.040
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.116720e-01	0.040
HDL remodeling	R-HSA-8964058	9.116720e-01	0.040
Maturation of nucleoprotein	R-HSA-9694631	9.116720e-01	0.040
Striated Muscle Contraction	R-HSA-390522	9.116824e-01	0.040
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.116824e-01	0.040
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.116824e-01	0.040
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.116890e-01	0.040
MAPK1/MAPK3 signaling	R-HSA-5684996	9.120784e-01	0.040
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.154481e-01	0.038
Potential therapeutics for SARS	R-HSA-9679191	9.155306e-01	0.038
HCMV Early Events	R-HSA-9609690	9.160888e-01	0.038
Telomere Maintenance	R-HSA-157579	9.184015e-01	0.037
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.185858e-01	0.037
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.185858e-01	0.037
Mitophagy	R-HSA-5205647	9.185858e-01	0.037
Leishmania phagocytosis	R-HSA-9664417	9.188319e-01	0.037
Parasite infection	R-HSA-9664407	9.188319e-01	0.037
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.188319e-01	0.037
Formation of definitive endoderm	R-HSA-9823730	9.201727e-01	0.036
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.201727e-01	0.036
Pregnenolone biosynthesis	R-HSA-196108	9.201727e-01	0.036
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.201727e-01	0.036
Signaling by NODAL	R-HSA-1181150	9.201727e-01	0.036
Plasma lipoprotein remodeling	R-HSA-8963899	9.212722e-01	0.036
NCAM signaling for neurite out-growth	R-HSA-375165	9.223841e-01	0.035
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.224954e-01	0.035
Reproduction	R-HSA-1474165	9.226131e-01	0.035
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.249790e-01	0.034
PERK regulates gene expression	R-HSA-381042	9.249790e-01	0.034
FOXO-mediated transcription	R-HSA-9614085	9.266355e-01	0.033
DNA Damage Bypass	R-HSA-73893	9.267270e-01	0.033
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.278557e-01	0.033
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.278557e-01	0.033
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.278557e-01	0.033
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.278557e-01	0.033
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.278557e-01	0.033
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	9.278557e-01	0.033
Lagging Strand Synthesis	R-HSA-69186	9.278557e-01	0.033
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.290705e-01	0.032
Cellular responses to stress	R-HSA-2262752	9.304428e-01	0.031
Calmodulin induced events	R-HSA-111933	9.308962e-01	0.031
CaM pathway	R-HSA-111997	9.308962e-01	0.031
FGFR2 mutant receptor activation	R-HSA-1839126	9.308962e-01	0.031
Regulation of RAS by GAPs	R-HSA-5658442	9.318329e-01	0.031
Insulin receptor signalling cascade	R-HSA-74751	9.319011e-01	0.031
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.319181e-01	0.031
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.319181e-01	0.031
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.347997e-01	0.029
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.347997e-01	0.029
Mitochondrial calcium ion transport	R-HSA-8949215	9.347997e-01	0.029
Voltage gated Potassium channels	R-HSA-1296072	9.363699e-01	0.029
TRAF6 mediated IRF7 activation	R-HSA-933541	9.363699e-01	0.029
NCAM1 interactions	R-HSA-419037	9.363699e-01	0.029
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.373066e-01	0.028
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.410745e-01	0.026
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.410745e-01	0.026
Uptake and actions of bacterial toxins	R-HSA-5339562	9.410745e-01	0.026
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.410756e-01	0.026
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.410756e-01	0.026
Signaling by KIT in disease	R-HSA-9669938	9.410756e-01	0.026
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.410756e-01	0.026
Ethanol oxidation	R-HSA-71384	9.410756e-01	0.026
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.410756e-01	0.026
PKR-mediated signaling	R-HSA-9833482	9.417340e-01	0.026
Signaling by FGFR2	R-HSA-5654738	9.417340e-01	0.026
Integration of energy metabolism	R-HSA-163685	9.445333e-01	0.025
Smooth Muscle Contraction	R-HSA-445355	9.452468e-01	0.024
Stabilization of p53	R-HSA-69541	9.461069e-01	0.024
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.467478e-01	0.024
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.467478e-01	0.024
Termination of O-glycan biosynthesis	R-HSA-977068	9.467478e-01	0.024
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.467478e-01	0.024
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.467478e-01	0.024
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.467478e-01	0.024
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.467478e-01	0.024
Organic anion transport by SLCO transporters	R-HSA-879518	9.467478e-01	0.024
Syndecan interactions	R-HSA-3000170	9.467478e-01	0.024
RSV-host interactions	R-HSA-9833110	9.471353e-01	0.024
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.491430e-01	0.023
Signaling by Hedgehog	R-HSA-5358351	9.497040e-01	0.022
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.503678e-01	0.022
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.504261e-01	0.022
Attenuation phase	R-HSA-3371568	9.504261e-01	0.022
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.504261e-01	0.022
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.504261e-01	0.022
Generation of second messenger molecules	R-HSA-202433	9.504261e-01	0.022
Glycogen metabolism	R-HSA-8982491	9.504261e-01	0.022
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	9.518743e-01	0.021
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.518743e-01	0.021
CD209 (DC-SIGN) signaling	R-HSA-5621575	9.518743e-01	0.021
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.518743e-01	0.021
Synthesis of dolichyl-phosphate	R-HSA-446199	9.518743e-01	0.021
TNFs bind their physiological receptors	R-HSA-5669034	9.518743e-01	0.021
Neddylation	R-HSA-8951664	9.521682e-01	0.021
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.532247e-01	0.021
SARS-CoV-1 Infection	R-HSA-9678108	9.543175e-01	0.020
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.544134e-01	0.020
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.544134e-01	0.020
Maturation of spike protein	R-HSA-9694548	9.544134e-01	0.020
Polymerase switching on the C-strand of the telomere	R-HSA-174411	9.565076e-01	0.019
Acyl chain remodelling of PS	R-HSA-1482801	9.565076e-01	0.019
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.565076e-01	0.019
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.565076e-01	0.019
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.566646e-01	0.019
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.577977e-01	0.019
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.577977e-01	0.019
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.580929e-01	0.019
HIV Transcription Initiation	R-HSA-167161	9.580929e-01	0.019
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.580929e-01	0.019
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.580929e-01	0.019
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.580929e-01	0.019
Scavenging by Class A Receptors	R-HSA-3000480	9.580929e-01	0.019
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.580929e-01	0.019
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.584971e-01	0.018
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.602772e-01	0.018
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.606950e-01	0.017
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	9.606950e-01	0.017
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.606950e-01	0.017
Suppression of phagosomal maturation	R-HSA-9637687	9.606950e-01	0.017
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.606950e-01	0.017
Urea cycle	R-HSA-70635	9.606950e-01	0.017
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.606950e-01	0.017
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.606950e-01	0.017
HCMV Infection	R-HSA-9609646	9.613085e-01	0.017
Ca-dependent events	R-HSA-111996	9.614867e-01	0.017
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.614867e-01	0.017
Dual incision in TC-NER	R-HSA-6782135	9.622828e-01	0.017
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.622828e-01	0.017
SARS-CoV-2-host interactions	R-HSA-9705683	9.641812e-01	0.016
Packaging Of Telomere Ends	R-HSA-171306	9.644795e-01	0.016
Cristae formation	R-HSA-8949613	9.644795e-01	0.016
Triglyceride biosynthesis	R-HSA-75109	9.644795e-01	0.016
Synthesis of PE	R-HSA-1483213	9.644795e-01	0.016
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.644795e-01	0.016
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.644795e-01	0.016
Insulin processing	R-HSA-264876	9.644795e-01	0.016
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.644795e-01	0.016
RNA Polymerase II Promoter Escape	R-HSA-73776	9.646158e-01	0.016
Defective pyroptosis	R-HSA-9710421	9.646158e-01	0.016
Signaling by FGFR4	R-HSA-5654743	9.646158e-01	0.016
Chaperonin-mediated protein folding	R-HSA-390466	9.649073e-01	0.016
HCMV Late Events	R-HSA-9610379	9.652276e-01	0.015
G1 Phase	R-HSA-69236	9.674996e-01	0.014
Cyclin D associated events in G1	R-HSA-69231	9.674996e-01	0.014
Amine ligand-binding receptors	R-HSA-375280	9.674996e-01	0.014
Signaling by Retinoic Acid	R-HSA-5362517	9.675852e-01	0.014
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.677398e-01	0.014
Protein ubiquitination	R-HSA-8852135	9.677398e-01	0.014
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.678998e-01	0.014
Pyrimidine salvage	R-HSA-73614	9.678998e-01	0.014
Interferon gamma signaling	R-HSA-877300	9.685254e-01	0.014
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.701563e-01	0.013
Asymmetric localization of PCP proteins	R-HSA-4608870	9.701563e-01	0.013
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.701563e-01	0.013
DAG and IP3 signaling	R-HSA-1489509	9.701563e-01	0.013
Signaling by FGFR3	R-HSA-5654741	9.701563e-01	0.013
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.706130e-01	0.013
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.709909e-01	0.013
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.709909e-01	0.013
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.709909e-01	0.013
Termination of translesion DNA synthesis	R-HSA-5656169	9.709909e-01	0.013
Base Excision Repair	R-HSA-73884	9.711458e-01	0.013
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.721779e-01	0.012
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.726030e-01	0.012
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.733632e-01	0.012
SHC1 events in ERBB2 signaling	R-HSA-1250196	9.737846e-01	0.012
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.737846e-01	0.012
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.737846e-01	0.012
Platelet degranulation	R-HSA-114608	9.743924e-01	0.011
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.748554e-01	0.011
Synthesis of PC	R-HSA-1483191	9.748554e-01	0.011
Adaptive Immune System	R-HSA-1280218	9.754195e-01	0.011
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.763093e-01	0.010
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.763093e-01	0.010
Protein folding	R-HSA-391251	9.763423e-01	0.010
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.763423e-01	0.010
Cap-dependent Translation Initiation	R-HSA-72737	9.764882e-01	0.010
Eukaryotic Translation Initiation	R-HSA-72613	9.764882e-01	0.010
Intraflagellar transport	R-HSA-5620924	9.769282e-01	0.010
GPER1 signaling	R-HSA-9634597	9.769282e-01	0.010
Metal ion SLC transporters	R-HSA-425410	9.769282e-01	0.010
Developmental Cell Lineages	R-HSA-9734767	9.773601e-01	0.010
DAG1 glycosylations	R-HSA-8931838	9.785910e-01	0.009
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.785910e-01	0.009
Cytokine Signaling in Immune system	R-HSA-1280215	9.787589e-01	0.009
SLC transporter disorders	R-HSA-5619102	9.790833e-01	0.009
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.795772e-01	0.009
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.801636e-01	0.009
Signaling by FGFR2 in disease	R-HSA-5655253	9.805890e-01	0.009
Defective B3GALTL causes PpS	R-HSA-5083635	9.806531e-01	0.008
Recycling of bile acids and salts	R-HSA-159418	9.806531e-01	0.008
Cardiac conduction	R-HSA-5576891	9.808068e-01	0.008
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.825167e-01	0.008
Glucagon signaling in metabolic regulation	R-HSA-163359	9.825167e-01	0.008
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.829291e-01	0.007
tRNA processing	R-HSA-72306	9.830472e-01	0.007
RNA Polymerase I Promoter Escape	R-HSA-73772	9.836835e-01	0.007
Dual Incision in GG-NER	R-HSA-5696400	9.842009e-01	0.007
NOD1/2 Signaling Pathway	R-HSA-168638	9.842009e-01	0.007
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.842009e-01	0.007
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.842009e-01	0.007
Signaling by NOTCH2	R-HSA-1980145	9.842009e-01	0.007
Calnexin/calreticulin cycle	R-HSA-901042	9.842009e-01	0.007
Signal amplification	R-HSA-392518	9.842009e-01	0.007
Regulation of PTEN stability and activity	R-HSA-8948751	9.850453e-01	0.007
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.850755e-01	0.007
Signaling by FGFR	R-HSA-190236	9.852669e-01	0.006
Regulation of Apoptosis	R-HSA-169911	9.857229e-01	0.006
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.857229e-01	0.006
Transferrin endocytosis and recycling	R-HSA-917977	9.857229e-01	0.006
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.862100e-01	0.006
ECM proteoglycans	R-HSA-3000178	9.862100e-01	0.006
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.862963e-01	0.006
Beta-catenin independent WNT signaling	R-HSA-3858494	9.865368e-01	0.006
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.866177e-01	0.006
Gastrulation	R-HSA-9758941	9.868157e-01	0.006
HSF1 activation	R-HSA-3371511	9.870984e-01	0.006
Lysosome Vesicle Biogenesis	R-HSA-432720	9.870984e-01	0.006
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.870984e-01	0.006
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.870984e-01	0.006
Extra-nuclear estrogen signaling	R-HSA-9009391	9.880226e-01	0.005
Signaling by NOTCH	R-HSA-157118	9.880270e-01	0.005
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.883415e-01	0.005
Degradation of DVL	R-HSA-4641258	9.883415e-01	0.005
Cleavage of the damaged purine	R-HSA-110331	9.883415e-01	0.005
SLC-mediated transport of organic cations	R-HSA-549127	9.883415e-01	0.005
Ion homeostasis	R-HSA-5578775	9.884999e-01	0.005
Signaling by FGFR1	R-HSA-5654736	9.884999e-01	0.005
Interleukin-1 family signaling	R-HSA-446652	9.889240e-01	0.005
tRNA processing in the mitochondrion	R-HSA-6785470	9.894648e-01	0.005
Depurination	R-HSA-73927	9.894648e-01	0.005
Dectin-2 family	R-HSA-5621480	9.894680e-01	0.005
Influenza Infection	R-HSA-168255	9.895737e-01	0.005
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.897194e-01	0.004
Neurotransmitter release cycle	R-HSA-112310	9.898462e-01	0.004
Signaling by Interleukins	R-HSA-449147	9.902377e-01	0.004
Opioid Signalling	R-HSA-111885	9.902855e-01	0.004
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.904800e-01	0.004
Pentose phosphate pathway	R-HSA-71336	9.904800e-01	0.004
Amino acid transport across the plasma membrane	R-HSA-352230	9.911715e-01	0.004
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.912545e-01	0.004
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.913974e-01	0.004
Diseases of Immune System	R-HSA-5260271	9.913974e-01	0.004
rRNA processing in the mitochondrion	R-HSA-8868766	9.913974e-01	0.004
Translation of Structural Proteins	R-HSA-9694635	9.914624e-01	0.004
Cellular responses to stimuli	R-HSA-8953897	9.916272e-01	0.004
Signaling by Insulin receptor	R-HSA-74752	9.918865e-01	0.004
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.918865e-01	0.004
Cholesterol biosynthesis	R-HSA-191273	9.921244e-01	0.003
Integrin cell surface interactions	R-HSA-216083	9.921244e-01	0.003
SARS-CoV-2 Infection	R-HSA-9694516	9.922278e-01	0.003
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.924746e-01	0.003
Aquaporin-mediated transport	R-HSA-445717	9.926046e-01	0.003
Endogenous sterols	R-HSA-211976	9.926046e-01	0.003
PLC beta mediated events	R-HSA-112043	9.926046e-01	0.003
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.926046e-01	0.003
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.929756e-01	0.003
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.929756e-01	0.003
Intra-Golgi traffic	R-HSA-6811438	9.929756e-01	0.003
Translation of Structural Proteins	R-HSA-9683701	9.929756e-01	0.003
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.930516e-01	0.003
Muscle contraction	R-HSA-397014	9.930516e-01	0.003
Co-inhibition by PD-1	R-HSA-389948	9.931601e-01	0.003
Mitochondrial protein import	R-HSA-1268020	9.932331e-01	0.003
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.933027e-01	0.003
Cytosolic tRNA aminoacylation	R-HSA-379716	9.936526e-01	0.003
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	9.936526e-01	0.003
Formation of a pool of free 40S subunits	R-HSA-72689	9.940035e-01	0.003
Ion channel transport	R-HSA-983712	9.940472e-01	0.003
Defensins	R-HSA-1461973	9.942644e-01	0.002
Ion transport by P-type ATPases	R-HSA-936837	9.943372e-01	0.002
Regulation of T cell activation by CD28 family	R-HSA-388841	9.945689e-01	0.002
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.948173e-01	0.002
Proteasome assembly	R-HSA-9907900	9.948173e-01	0.002
Surfactant metabolism	R-HSA-5683826	9.948173e-01	0.002
Cellular response to hypoxia	R-HSA-1234174	9.948210e-01	0.002
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.949842e-01	0.002
Post-translational protein phosphorylation	R-HSA-8957275	9.952312e-01	0.002
Regulation of insulin secretion	R-HSA-422356	9.952312e-01	0.002
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.953169e-01	0.002
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.953169e-01	0.002
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.953169e-01	0.002
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.953169e-01	0.002
SARS-CoV Infections	R-HSA-9679506	9.956526e-01	0.002
G-protein mediated events	R-HSA-112040	9.956700e-01	0.002
Kidney development	R-HSA-9830369	9.956700e-01	0.002
Metabolism of steroid hormones	R-HSA-196071	9.956700e-01	0.002
SLC-mediated transport of amino acids	R-HSA-9958863	9.956700e-01	0.002
Condensation of Prophase Chromosomes	R-HSA-2299718	9.957684e-01	0.002
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.957684e-01	0.002
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.959016e-01	0.002
Pyruvate metabolism	R-HSA-70268	9.965258e-01	0.002
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.966934e-01	0.001
Cellular response to starvation	R-HSA-9711097	9.967995e-01	0.001
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.968782e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.968782e-01	0.001
Retinoid metabolism and transport	R-HSA-975634	9.969785e-01	0.001
Phospholipid metabolism	R-HSA-1483257	9.971945e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.972066e-01	0.001
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.972210e-01	0.001
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.972393e-01	0.001
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.974512e-01	0.001
Meiotic recombination	R-HSA-912446	9.974512e-01	0.001
Hedgehog ligand biogenesis	R-HSA-5358346	9.974512e-01	0.001
Complex IV assembly	R-HSA-9864848	9.974512e-01	0.001
Branched-chain amino acid catabolism	R-HSA-70895	9.974512e-01	0.001
The phototransduction cascade	R-HSA-2514856	9.974512e-01	0.001
Platelet homeostasis	R-HSA-418346	9.976276e-01	0.001
Platelet activation, signaling and aggregation	R-HSA-76002	9.978825e-01	0.001
Protein localization	R-HSA-9609507	9.983584e-01	0.001
PCP/CE pathway	R-HSA-4086400	9.983983e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.983983e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.983983e-01	0.001
FCERI mediated MAPK activation	R-HSA-2871796	9.985229e-01	0.001
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.985378e-01	0.001
Potassium Channels	R-HSA-1296071	9.986168e-01	0.001
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.986447e-01	0.001
Transmission across Chemical Synapses	R-HSA-112315	9.986979e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.987329e-01	0.001
C-type lectin receptors (CLRs)	R-HSA-5621481	9.987329e-01	0.001
Cellular responses to mechanical stimuli	R-HSA-9855142	9.987405e-01	0.001
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.987819e-01	0.001
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.988372e-01	0.001
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.988410e-01	0.001
Peroxisomal protein import	R-HSA-9033241	9.988678e-01	0.000
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.989127e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.989771e-01	0.000
Formation of paraxial mesoderm	R-HSA-9793380	9.990758e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.990758e-01	0.000
Interleukin-1 signaling	R-HSA-9020702	9.990956e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.992455e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.992975e-01	0.000
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.993003e-01	0.000
Response of endothelial cells to shear stress	R-HSA-9860931	9.993003e-01	0.000
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.993183e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.993306e-01	0.000
Leishmania infection	R-HSA-9658195	9.993306e-01	0.000
Hemostasis	R-HSA-109582	9.993609e-01	0.000
Cellular response to chemical stress	R-HSA-9711123	9.993671e-01	0.000
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.993898e-01	0.000
Peptide chain elongation	R-HSA-156902	9.994157e-01	0.000
ER-Phagosome pathway	R-HSA-1236974	9.994672e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.994973e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.994973e-01	0.000
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.995039e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.995142e-01	0.000
Antigen processing-Cross presentation	R-HSA-1236975	9.995449e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.995458e-01	0.000
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.995571e-01	0.000
rRNA processing	R-HSA-72312	9.995931e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.996019e-01	0.000
Eukaryotic Translation Elongation	R-HSA-156842	9.996320e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.996651e-01	0.000
Neuronal System	R-HSA-112316	9.996909e-01	0.000
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.997214e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.997266e-01	0.000
Eukaryotic Translation Termination	R-HSA-72764	9.997462e-01	0.000
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.997462e-01	0.000
Signaling by NOTCH4	R-HSA-9013694	9.997530e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.997769e-01	0.000
Iron uptake and transport	R-HSA-917937	9.997769e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.998251e-01	0.000
ABC transporter disorders	R-HSA-5619084	9.998355e-01	0.000
ABC-family proteins mediated transport	R-HSA-382556	9.998407e-01	0.000
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.998476e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.998514e-01	0.000
Selenocysteine synthesis	R-HSA-2408557	9.998549e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.998770e-01	0.000
Amyloid fiber formation	R-HSA-977225	9.998787e-01	0.000
Viral mRNA Translation	R-HSA-192823	9.998797e-01	0.000
Ribosome-associated quality control	R-HSA-9948299	9.998829e-01	0.000
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.999010e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.999056e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999276e-01	0.000
TCR signaling	R-HSA-202403	9.999432e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999432e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999483e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999683e-01	0.000
FCGR activation	R-HSA-2029481	9.999708e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999736e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999773e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999916e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999922e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999934e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999951e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999951e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999952e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999959e-01	0.000
Viral Infection Pathways	R-HSA-9824446	9.999960e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999962e-01	0.000
Neutrophil degranulation	R-HSA-6798695	9.999973e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999975e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999979e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999979e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.999982e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999983e-01	0.000
Immune System	R-HSA-168256	9.999984e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999984e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999987e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999993e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999996e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999996e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999997e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999997e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999997e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999999e-01	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
G alpha (q) signalling events	R-HSA-416476	1.000000e+00	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Translation	R-HSA-72766	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.067931e-09	8.971
mRNA Splicing	R-HSA-72172	6.444621e-08	7.191
mRNA Splicing - Major Pathway	R-HSA-72163	7.655755e-08	7.116
mRNA 3'-end processing	R-HSA-72187	3.629727e-06	5.440
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	8.962721e-06	5.048
Signaling by ALK in cancer	R-HSA-9700206	8.962721e-06	5.048
Metabolism of RNA	R-HSA-8953854	9.404307e-06	5.027
RNA Polymerase II Transcription Termination	R-HSA-73856	2.800156e-05	4.553
ATP-dependent chromatin remodelers	R-HSA-9932444	4.202648e-05	4.376
SWI/SNF chromatin remodelers	R-HSA-9932451	4.202648e-05	4.376
Cell Cycle	R-HSA-1640170	4.568689e-05	4.340
Chromatin organization	R-HSA-4839726	4.908238e-05	4.309
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.153313e-05	4.211
Attenuation phase	R-HSA-3371568	2.254400e-04	3.647
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.339604e-04	3.631
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.482686e-04	3.605
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.573226e-04	3.590
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.020913e-04	3.520
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.089015e-04	3.510
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.846597e-04	3.415
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	4.483826e-04	3.348
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.705800e-04	3.327
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.339133e-04	3.273
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.816965e-04	3.235
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	8.380032e-04	3.077
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.206229e-04	3.086
HSF1 activation	R-HSA-3371511	9.328137e-04	3.030
Chromatin modifying enzymes	R-HSA-3247509	9.116548e-04	3.040
Apoptotic execution phase	R-HSA-75153	9.189367e-04	3.037
Gene expression (Transcription)	R-HSA-74160	9.684469e-04	3.014
Cell Cycle, Mitotic	R-HSA-69278	1.144595e-03	2.941
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.358226e-03	2.867
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.330551e-03	2.876
Cellular response to heat stress	R-HSA-3371556	1.829551e-03	2.738
ALK mutants bind TKIs	R-HSA-9700645	2.051817e-03	2.688
Cellular Senescence	R-HSA-2559583	2.000074e-03	2.699
HSF1-dependent transactivation	R-HSA-3371571	2.142274e-03	2.669
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.888292e-03	2.539
RNA Polymerase II Transcription	R-HSA-73857	3.223401e-03	2.492
Nuclear RNA decay	R-HSA-9930044	3.736630e-03	2.428
DNA Double-Strand Break Repair	R-HSA-5693532	3.801143e-03	2.420
NRAGE signals death through JNK	R-HSA-193648	4.490250e-03	2.348
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.567434e-03	2.340
RUNX3 regulates WNT signaling	R-HSA-8951430	4.763283e-03	2.322
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	4.763283e-03	2.322
Mitotic Telophase/Cytokinesis	R-HSA-68884	6.001674e-03	2.222
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.242487e-03	2.205
Sema4D in semaphorin signaling	R-HSA-400685	6.923164e-03	2.160
Calmodulin induced events	R-HSA-111933	7.517606e-03	2.124
CaM pathway	R-HSA-111997	7.517606e-03	2.124
Transcriptional regulation by RUNX1	R-HSA-8878171	6.947446e-03	2.158
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.635516e-03	2.117
AKT phosphorylates targets in the cytosol	R-HSA-198323	8.094497e-03	2.092
Processing of Intronless Pre-mRNAs	R-HSA-77595	8.122109e-03	2.090
Cellular responses to stimuli	R-HSA-8953897	8.713035e-03	2.060
AKT phosphorylates targets in the nucleus	R-HSA-198693	9.981158e-03	2.001
Signaling by Hippo	R-HSA-2028269	1.028544e-02	1.988
Regulation of MECP2 expression and activity	R-HSA-9022692	1.035083e-02	1.985
Activation of ATR in response to replication stress	R-HSA-176187	1.035083e-02	1.985
M Phase	R-HSA-68886	1.073877e-02	1.969
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.215507e-02	1.915
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.193002e-02	1.923
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.177650e-02	1.929
Oxidative Stress Induced Senescence	R-HSA-2559580	1.179939e-02	1.928
Transcriptional Regulation by E2F6	R-HSA-8953750	1.193002e-02	1.923
PKA activation	R-HSA-163615	1.284020e-02	1.891
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.284020e-02	1.891
MITF-M-regulated melanocyte development	R-HSA-9730414	1.276839e-02	1.894
Nuclear Receptor transcription pathway	R-HSA-383280	1.286218e-02	1.891
Epigenetic regulation of gene expression	R-HSA-212165	1.295096e-02	1.888
Transcriptional Regulation by MECP2	R-HSA-8986944	1.303097e-02	1.885
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.377026e-02	1.861
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.478835e-02	1.830
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.525783e-02	1.817
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.555029e-02	1.808
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.655440e-02	1.781
DNA Repair	R-HSA-73894	1.628354e-02	1.788
PKMTs methylate histone lysines	R-HSA-3214841	1.581728e-02	1.801
MITF-M-dependent gene expression	R-HSA-9856651	1.589674e-02	1.799
Nucleotide Excision Repair	R-HSA-5696398	1.662473e-02	1.779
Activation of the pre-replicative complex	R-HSA-68962	1.681714e-02	1.774
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.700575e-02	1.769
Diseases of Telomere Maintenance	R-HSA-9673013	1.974162e-02	1.705
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.974162e-02	1.705
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.974162e-02	1.705
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.974162e-02	1.705
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.974162e-02	1.705
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.974162e-02	1.705
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.926358e-02	1.715
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.925567e-02	1.715
NGF-stimulated transcription	R-HSA-9031628	1.925567e-02	1.715
Cellular responses to stress	R-HSA-2262752	1.844919e-02	1.734
Regulation of TP53 Activity	R-HSA-5633007	1.871870e-02	1.728
MTOR signalling	R-HSA-165159	2.058408e-02	1.686
Ca-dependent events	R-HSA-111996	2.058408e-02	1.686
MECP2 regulates transcription factors	R-HSA-9022707	2.328103e-02	1.633
Cohesin Loading onto Chromatin	R-HSA-2470946	2.328103e-02	1.633
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.180591e-02	1.661
Signaling by PTK6	R-HSA-8848021	2.282438e-02	1.642
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.282438e-02	1.642
Nuclear Envelope Breakdown	R-HSA-2980766	2.496208e-02	1.603
G alpha (12/13) signalling events	R-HSA-416482	2.518904e-02	1.599
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.719730e-02	1.565
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.772122e-02	1.557
Transcriptional regulation by RUNX3	R-HSA-8878159	2.604727e-02	1.584
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.782184e-02	1.556
IRE1alpha activates chaperones	R-HSA-381070	2.664335e-02	1.574
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.992586e-02	1.524
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.016696e-02	1.520
Formation of RNA Pol II elongation complex	R-HSA-112382	3.035887e-02	1.518
Homology Directed Repair	R-HSA-5693538	2.973244e-02	1.527
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.035887e-02	1.518
DAG and IP3 signaling	R-HSA-1489509	2.960592e-02	1.529
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.955630e-02	1.529
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.960592e-02	1.529
Transcriptional Regulation by TP53	R-HSA-3700989	3.028813e-02	1.519
XBP1(S) activates chaperone genes	R-HSA-381038	2.955630e-02	1.529
ROBO receptors bind AKAP5	R-HSA-9010642	3.141291e-02	1.503
Unfolded Protein Response (UPR)	R-HSA-381119	3.226735e-02	1.491
Notch-HLH transcription pathway	R-HSA-350054	3.265417e-02	1.486
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.373635e-02	1.472
Meiotic synapsis	R-HSA-1221632	3.373635e-02	1.472
DNA Double Strand Break Response	R-HSA-5693606	3.374615e-02	1.472
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	3.724308e-02	1.429
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.724308e-02	1.429
Mitotic Anaphase	R-HSA-68882	3.543589e-02	1.451
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.723833e-02	1.429
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.724308e-02	1.429
Protein ubiquitination	R-HSA-8852135	3.641265e-02	1.439
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.739807e-02	1.427
Cell Cycle Checkpoints	R-HSA-69620	3.860254e-02	1.413
PKA activation in glucagon signalling	R-HSA-164378	3.880092e-02	1.411
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	3.999032e-02	1.398
Breakdown of the nuclear lamina	R-HSA-352238	4.144027e-02	1.383
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.438660e-02	1.353
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	4.556659e-02	1.341
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.530005e-02	1.257
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.210213e-02	1.283
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.491181e-02	1.260
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.473173e-02	1.262
Diseases of mitotic cell cycle	R-HSA-9675126	5.406198e-02	1.267
Cellular responses to mechanical stimuli	R-HSA-9855142	5.498668e-02	1.260
Generic Transcription Pathway	R-HSA-212436	5.575254e-02	1.254
p75 NTR receptor-mediated signalling	R-HSA-193704	5.254015e-02	1.280
Mitotic Spindle Checkpoint	R-HSA-69618	5.623904e-02	1.250
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.877664e-02	1.163
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.877664e-02	1.163
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.877664e-02	1.163
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.877664e-02	1.163
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.877664e-02	1.163
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.877664e-02	1.163
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.877664e-02	1.163
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.877664e-02	1.163
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.877664e-02	1.163
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.877664e-02	1.163
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.877664e-02	1.163
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	7.297719e-02	1.137
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.297719e-02	1.137
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	6.465603e-02	1.189
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.204012e-02	1.142
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	6.653759e-02	1.177
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	6.653759e-02	1.177
Transport of the SLBP independent Mature mRNA	R-HSA-159227	6.090086e-02	1.215
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	6.825833e-02	1.166
mRNA Splicing - Minor Pathway	R-HSA-72165	6.793026e-02	1.168
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.130583e-02	1.212
Chromosome Maintenance	R-HSA-73886	5.937555e-02	1.226
Eukaryotic Translation Initiation	R-HSA-72613	7.017413e-02	1.154
Cap-dependent Translation Initiation	R-HSA-72737	7.017413e-02	1.154
Formation of Incision Complex in GG-NER	R-HSA-5696395	6.855506e-02	1.164
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	5.853297e-02	1.233
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.116736e-02	1.213
Processing of DNA double-strand break ends	R-HSA-5693607	5.904245e-02	1.229
CREB phosphorylation	R-HSA-199920	7.297719e-02	1.137
Neurofascin interactions	R-HSA-447043	7.297719e-02	1.137
G2/M DNA damage checkpoint	R-HSA-69473	6.116736e-02	1.213
Myogenesis	R-HSA-525793	5.853297e-02	1.233
PLC beta mediated events	R-HSA-112043	7.073511e-02	1.150
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.090086e-02	1.215
Regulation of PTEN gene transcription	R-HSA-8943724	6.507930e-02	1.187
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	7.204012e-02	1.142
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.516912e-02	1.124
HIV elongation arrest and recovery	R-HSA-167287	7.516912e-02	1.124
Pausing and recovery of HIV elongation	R-HSA-167290	7.516912e-02	1.124
Dual Incision in GG-NER	R-HSA-5696400	7.613823e-02	1.118
Disorders of Developmental Biology	R-HSA-9675151	7.666960e-02	1.115
Mitotic Prometaphase	R-HSA-68877	7.670379e-02	1.115
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	7.863971e-02	1.104
HDACs deacetylate histones	R-HSA-3214815	7.928033e-02	1.101
Regulation of CDH1 Gene Transcription	R-HSA-9764560	7.976748e-02	1.098
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	9.282738e-02	1.032
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	9.282738e-02	1.032
PTK6 Expression	R-HSA-8849473	9.282738e-02	1.032
Disorders of Nervous System Development	R-HSA-9697154	9.399497e-02	1.027
Pervasive developmental disorders	R-HSA-9005895	9.399497e-02	1.027
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	9.399497e-02	1.027
FGFR2 alternative splicing	R-HSA-6803529	8.229115e-02	1.085
PRC2 methylates histones and DNA	R-HSA-212300	9.346704e-02	1.029
Ribosomal scanning and start codon recognition	R-HSA-72702	8.608952e-02	1.065
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	8.404238e-02	1.076
Amplification of signal from the kinetochores	R-HSA-141424	8.404238e-02	1.076
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	8.585083e-02	1.066
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	8.772969e-02	1.057
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	9.399497e-02	1.027
G2/M Checkpoints	R-HSA-69481	8.805937e-02	1.055
Mitotic Prophase	R-HSA-68875	8.798786e-02	1.056
HIV Life Cycle	R-HSA-162587	9.118440e-02	1.040
Macroautophagy	R-HSA-1632852	8.774950e-02	1.057
Semaphorin interactions	R-HSA-373755	8.297413e-02	1.081
Deubiquitination	R-HSA-5688426	9.388860e-02	1.027
Signal Transduction	R-HSA-162582	9.449951e-02	1.025
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.003896e-01	0.998
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.003896e-01	0.998
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.003896e-01	0.998
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.011413e-01	0.995
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.011413e-01	0.995
Estrogen-dependent gene expression	R-HSA-9018519	1.022073e-01	0.991
MGMT-mediated DNA damage reversal	R-HSA-5657655	1.920583e-01	0.717
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.920583e-01	0.717
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.920583e-01	0.717
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.920583e-01	0.717
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.920583e-01	0.717
Hereditary fructose intolerance	R-HSA-5657560	1.920583e-01	0.717
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.351356e-01	0.869
Regulation of gap junction activity	R-HSA-191650	1.351356e-01	0.869
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.351356e-01	0.869
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	1.351356e-01	0.869
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	1.351356e-01	0.869
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.351356e-01	0.869
Signaling by FGFR3 fusions in cancer	R-HSA-8853334	2.737842e-01	0.563
t(4;14) translocations of FGFR3	R-HSA-2033515	2.737842e-01	0.563
Signaling by TCF7L2 mutants	R-HSA-5339700	2.737842e-01	0.563
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.737842e-01	0.563
Defective VWF binding to collagen type I	R-HSA-9845622	2.737842e-01	0.563
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.737842e-01	0.563
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.737842e-01	0.563
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.720583e-01	0.764
IRS activation	R-HSA-74713	1.720583e-01	0.764
ARMS-mediated activation	R-HSA-170984	1.381347e-01	0.860
WNT mediated activation of DVL	R-HSA-201688	1.381347e-01	0.860
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.103625e-01	0.677
Defective ALG9 causes CDG-1l	R-HSA-4720454	3.472476e-01	0.459
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.472476e-01	0.459
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.472476e-01	0.459
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.472476e-01	0.459
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	3.472476e-01	0.459
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.472476e-01	0.459
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.472476e-01	0.459
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.472476e-01	0.459
Defective DHDDS causes RP59	R-HSA-4755609	3.472476e-01	0.459
FGFR3 mutant receptor activation	R-HSA-2033514	1.106467e-01	0.956
Signaling by activated point mutants of FGFR3	R-HSA-1839130	1.106467e-01	0.956
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.631031e-01	0.788
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.166977e-01	0.933
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.674431e-01	0.776
Signaling by AXIN mutants	R-HSA-4839735	2.164360e-01	0.665
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.164360e-01	0.665
Recycling of eIF2:GDP	R-HSA-72731	2.886074e-01	0.540
SOS-mediated signalling	R-HSA-112412	2.886074e-01	0.540
FGFR3b ligand binding and activation	R-HSA-190371	2.886074e-01	0.540
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.886074e-01	0.540
Defective MMACHC causes MAHCC	R-HSA-3359474	4.132833e-01	0.384
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.132833e-01	0.384
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.132833e-01	0.384
Defective ABCC2 causes DJS	R-HSA-5679001	4.132833e-01	0.384
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	4.132833e-01	0.384
Invadopodia formation	R-HSA-8941237	4.132833e-01	0.384
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.443275e-01	0.612
RUNX3 regulates p14-ARF	R-HSA-8951936	2.443275e-01	0.612
Repression of WNT target genes	R-HSA-4641265	2.443275e-01	0.612
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.443275e-01	0.612
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	2.099303e-01	0.678
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.099303e-01	0.678
RSK activation	R-HSA-444257	3.275733e-01	0.485
Signaling by MRAS-complex mutants	R-HSA-9660537	3.275733e-01	0.485
Formation of annular gap junctions	R-HSA-196025	3.275733e-01	0.485
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.275733e-01	0.485
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.591779e-01	0.798
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	2.322160e-01	0.634
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.342627e-01	0.872
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.342627e-01	0.872
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.185611e-01	0.926
Nucleosome assembly	R-HSA-774815	1.185611e-01	0.926
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.899763e-01	0.721
Signaling by FGFR2 IIIa TM	R-HSA-8851708	2.550416e-01	0.593
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	3.014721e-01	0.521
Gap junction degradation	R-HSA-190873	3.659388e-01	0.437
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.659388e-01	0.437
HCN channels	R-HSA-1296061	4.726421e-01	0.325
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.726421e-01	0.325
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.726421e-01	0.325
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	4.726421e-01	0.325
Defective LFNG causes SCDO3	R-HSA-5083630	4.726421e-01	0.325
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	4.726421e-01	0.325
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.061720e-01	0.686
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.061720e-01	0.686
Translation initiation complex formation	R-HSA-72649	1.319143e-01	0.880
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.940020e-01	0.712
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.605261e-01	0.794
Spry regulation of FGF signaling	R-HSA-1295596	3.303365e-01	0.481
Processive synthesis on the lagging strand	R-HSA-69183	3.303365e-01	0.481
IPs transport between nucleus and cytosol	R-HSA-1855170	2.399280e-01	0.620
Folding of actin by CCT/TriC	R-HSA-390450	4.034267e-01	0.394
Signaling by FGFR3 in disease	R-HSA-5655332	2.779895e-01	0.556
Processive synthesis on the C-strand of the telomere	R-HSA-174414	2.779895e-01	0.556
EPHA-mediated growth cone collapse	R-HSA-3928663	2.779895e-01	0.556
Interaction between L1 and Ankyrins	R-HSA-445095	2.779895e-01	0.556
Packaging Of Telomere Ends	R-HSA-171306	2.779895e-01	0.556
Striated Muscle Contraction	R-HSA-390522	2.573925e-01	0.589
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.591648e-01	0.445
Phosphorylation of the APC/C	R-HSA-176412	3.591648e-01	0.445
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.591648e-01	0.445
FRS-mediated FGFR3 signaling	R-HSA-5654706	3.256374e-01	0.487
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.085873e-01	0.681
Telomere Extension By Telomerase	R-HSA-171319	2.983276e-01	0.525
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.983276e-01	0.525
Formation of the Early Elongation Complex	R-HSA-113418	2.983276e-01	0.525
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.821614e-01	0.740
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.932502e-01	0.533
Negative regulation of FGFR4 signaling	R-HSA-5654733	3.188931e-01	0.496
DNA methylation	R-HSA-5334118	3.188931e-01	0.496
Impaired BRCA2 binding to RAD51	R-HSA-9709570	3.188931e-01	0.496
Signaling by APC mutants	R-HSA-4839744	4.398222e-01	0.357
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.398222e-01	0.357
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.398222e-01	0.357
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.398222e-01	0.357
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.259986e-01	0.279
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	5.259986e-01	0.279
FLT3 signaling by CBL mutants	R-HSA-9706377	5.259986e-01	0.279
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.259986e-01	0.279
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.259986e-01	0.279
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.493108e-01	0.826
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	2.479791e-01	0.606
RUNX2 regulates bone development	R-HSA-8941326	3.115451e-01	0.506
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.115451e-01	0.506
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.800294e-01	0.745
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.800294e-01	0.745
Deadenylation of mRNA	R-HSA-429947	3.972505e-01	0.401
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.749627e-01	0.323
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.749627e-01	0.323
Signaling by GSK3beta mutants	R-HSA-5339716	4.749627e-01	0.323
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.640852e-01	0.785
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.270769e-01	0.644
RNA Polymerase III Transcription Termination	R-HSA-73980	4.440037e-01	0.353
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.547951e-01	0.450
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.209213e-01	0.376
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.475984e-01	0.459
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.475984e-01	0.459
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.475984e-01	0.459
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	3.270132e-01	0.485
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	4.713419e-01	0.327
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.087297e-01	0.294
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.087297e-01	0.294
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.087297e-01	0.294
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.087297e-01	0.294
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.087297e-01	0.294
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.087297e-01	0.294
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.739594e-01	0.241
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.739594e-01	0.241
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.739594e-01	0.241
Noncanonical activation of NOTCH3	R-HSA-9017802	5.739594e-01	0.241
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.739594e-01	0.241
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.739594e-01	0.241
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.647256e-01	0.438
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.772219e-01	0.423
Formation of a pool of free 40S subunits	R-HSA-72689	3.445411e-01	0.463
Negative regulation of FGFR2 signaling	R-HSA-5654727	4.434685e-01	0.353
AURKA Activation by TPX2	R-HSA-8854518	3.921127e-01	0.407
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.677260e-01	0.434
Dual incision in TC-NER	R-HSA-6782135	4.068583e-01	0.391
Centrosome maturation	R-HSA-380287	3.927808e-01	0.406
Metabolism of non-coding RNA	R-HSA-194441	4.227689e-01	0.374
snRNP Assembly	R-HSA-191859	4.227689e-01	0.374
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.931205e-01	0.405
Activation of AMPK downstream of NMDARs	R-HSA-9619483	4.902850e-01	0.310
Adenylate cyclase activating pathway	R-HSA-170660	5.410415e-01	0.267
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.410415e-01	0.267
RNA Polymerase I Promoter Escape	R-HSA-73772	4.574027e-01	0.340
SHC-mediated cascade:FGFR3	R-HSA-5654704	5.240621e-01	0.281
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.240621e-01	0.281
mRNA Capping	R-HSA-72086	5.126526e-01	0.290
Termination of translesion DNA synthesis	R-HSA-5656169	5.126526e-01	0.290
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	5.126526e-01	0.290
Late endosomal microautophagy	R-HSA-9615710	5.126526e-01	0.290
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.126526e-01	0.290
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	5.040025e-01	0.298
SIRT1 negatively regulates rRNA expression	R-HSA-427359	5.040025e-01	0.298
Signaling downstream of RAS mutants	R-HSA-9649948	5.148906e-01	0.288
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.148906e-01	0.288
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.148906e-01	0.288
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	5.493117e-01	0.260
Removal of the Flap Intermediate	R-HSA-69166	5.718468e-01	0.243
Trafficking of AMPA receptors	R-HSA-399719	5.559596e-01	0.255
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	5.561509e-01	0.255
Transcriptional regulation by RUNX2	R-HSA-8878166	5.551468e-01	0.256
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.011198e-01	0.221
Adenylate cyclase inhibitory pathway	R-HSA-170670	6.011198e-01	0.221
Beta-catenin phosphorylation cascade	R-HSA-196299	6.011198e-01	0.221
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	5.802567e-01	0.236
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.973504e-01	0.224
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.973504e-01	0.224
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	5.846387e-01	0.233
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.872983e-01	0.231
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.872983e-01	0.231
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.872983e-01	0.231
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.872983e-01	0.231
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.872983e-01	0.231
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	5.971146e-01	0.224
HCMV Early Events	R-HSA-9609690	6.056563e-01	0.218
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.024575e-01	0.220
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	6.151539e-01	0.211
Transcription of the HIV genome	R-HSA-167172	2.960415e-01	0.529
Telomere Maintenance	R-HSA-157579	1.853358e-01	0.732
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	3.012372e-01	0.521
Extension of Telomeres	R-HSA-180786	2.896225e-01	0.538
RNA Polymerase III Transcription	R-HSA-74158	3.115451e-01	0.506
Signaling by FGFR2	R-HSA-5654738	3.400737e-01	0.468
Downstream signaling of activated FGFR3	R-HSA-5654708	5.126526e-01	0.290
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.664581e-01	0.436
EGFR downregulation	R-HSA-182971	5.559596e-01	0.255
Signaling by NOTCH1	R-HSA-1980143	5.389458e-01	0.268
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	4.234580e-01	0.373
Regulation of endogenous retroelements	R-HSA-9842860	1.583725e-01	0.800
HIV Transcription Elongation	R-HSA-167169	1.342627e-01	0.872
Negative regulation of FGFR1 signaling	R-HSA-5654726	4.021183e-01	0.396
Signaling by FGFR3	R-HSA-5654741	3.377720e-01	0.471
EPH-Ephrin signaling	R-HSA-2682334	5.255470e-01	0.279
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.345580e-01	0.272
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.727404e-01	0.564
Integrin signaling	R-HSA-354192	2.399280e-01	0.620
Signaling by FGFR	R-HSA-190236	3.807719e-01	0.419
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.154915e-01	0.937
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.899763e-01	0.721
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.332025e-01	0.363
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.498827e-01	0.602
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.099303e-01	0.678
VxPx cargo-targeting to cilium	R-HSA-5620916	4.980522e-01	0.303
Prolonged ERK activation events	R-HSA-169893	1.674431e-01	0.776
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.802567e-01	0.236
Signaling by ERBB2	R-HSA-1227986	4.386462e-01	0.358
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.018605e-01	0.520
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.092659e-01	0.679
DNA Damage Bypass	R-HSA-73893	5.670195e-01	0.246
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.342627e-01	0.872
Oncogenic MAPK signaling	R-HSA-6802957	5.318813e-01	0.274
Polo-like kinase mediated events	R-HSA-156711	2.322160e-01	0.634
PI-3K cascade:FGFR3	R-HSA-5654710	2.550416e-01	0.593
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.396187e-01	0.469
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.675032e-01	0.330
Signaling by RAF1 mutants	R-HSA-9656223	5.983196e-01	0.223
Frs2-mediated activation	R-HSA-170968	5.410415e-01	0.267
Chaperonin-mediated protein folding	R-HSA-390466	5.716901e-01	0.243
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.275740e-01	0.894
DCC mediated attractive signaling	R-HSA-418885	3.303365e-01	0.481
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.728954e-01	0.762
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	3.972505e-01	0.401
IRS-related events triggered by IGF1R	R-HSA-2428928	3.183371e-01	0.497
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.400737e-01	0.468
MAP2K and MAPK activation	R-HSA-5674135	5.983196e-01	0.223
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.233185e-01	0.909
PI3K/AKT activation	R-HSA-198203	4.034267e-01	0.394
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.495235e-01	0.457
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.242957e-01	0.906
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.749627e-01	0.323
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	5.737534e-01	0.241
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.772219e-01	0.423
Downregulation of ERBB2 signaling	R-HSA-8863795	1.899763e-01	0.721
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	1.285063e-01	0.891
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.443275e-01	0.612
GP1b-IX-V activation signalling	R-HSA-430116	3.659388e-01	0.437
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.396187e-01	0.469
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	4.434685e-01	0.353
Signaling by RAS mutants	R-HSA-6802949	5.148906e-01	0.288
IRS-mediated signalling	R-HSA-112399	5.401954e-01	0.267
Regulation of TP53 Degradation	R-HSA-6804757	3.115451e-01	0.506
IGF1R signaling cascade	R-HSA-2428924	3.623763e-01	0.441
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.720583e-01	0.764
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.883004e-01	0.725
mTORC1-mediated signalling	R-HSA-166208	1.821636e-01	0.740
Formation of axial mesoderm	R-HSA-9796292	2.727404e-01	0.564
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	3.659388e-01	0.437
TGFBR3 expression	R-HSA-9839394	2.382737e-01	0.623
Negative regulation of MET activity	R-HSA-6807004	2.782932e-01	0.555
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.392772e-01	0.621
DARPP-32 events	R-HSA-180024	3.188931e-01	0.496
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.259986e-01	0.279
Activation of RAC1	R-HSA-428540	4.749627e-01	0.323
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.814071e-01	0.551
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	4.440037e-01	0.353
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.087297e-01	0.294
RNA Polymerase I Transcription Termination	R-HSA-73863	4.675032e-01	0.330
Separation of Sister Chromatids	R-HSA-2467813	3.061955e-01	0.514
Telomere C-strand synthesis initiation	R-HSA-174430	6.011198e-01	0.221
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	5.685220e-01	0.245
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.579481e-01	0.588
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.443616e-01	0.352
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	4.713419e-01	0.327
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.958311e-01	0.305
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	1.166977e-01	0.933
Lagging Strand Synthesis	R-HSA-69186	5.240621e-01	0.281
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	5.884692e-01	0.230
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.662670e-01	0.331
Activation of HOX genes during differentiation	R-HSA-5619507	4.662670e-01	0.331
Nuclear import of Rev protein	R-HSA-180746	1.526132e-01	0.816
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	3.014721e-01	0.521
RNA Polymerase I Transcription	R-HSA-73864	3.140623e-01	0.503
NoRC negatively regulates rRNA expression	R-HSA-427413	4.664914e-01	0.331
Late Phase of HIV Life Cycle	R-HSA-162599	1.408086e-01	0.851
Cell-extracellular matrix interactions	R-HSA-446353	1.474742e-01	0.831
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.238081e-01	0.650
Deadenylation-dependent mRNA decay	R-HSA-429914	4.227689e-01	0.374
RNA Polymerase I Promoter Clearance	R-HSA-73854	4.068574e-01	0.391
Meiosis	R-HSA-1500620	2.000077e-01	0.699
Signaling by WNT in cancer	R-HSA-4791275	5.768218e-01	0.239
Clathrin-mediated endocytosis	R-HSA-8856828	4.521131e-01	0.345
Neurexins and neuroligins	R-HSA-6794361	1.135996e-01	0.945
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.730410e-01	0.242
TCF dependent signaling in response to WNT	R-HSA-201681	3.248897e-01	0.488
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	1.720583e-01	0.764
Pyrophosphate hydrolysis	R-HSA-71737	1.720583e-01	0.764
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.899763e-01	0.721
DNA strand elongation	R-HSA-69190	2.228383e-01	0.652
FGFR3 ligand binding and activation	R-HSA-190239	3.303365e-01	0.481
Glucagon signaling in metabolic regulation	R-HSA-163359	2.573925e-01	0.589
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.878054e-01	0.411
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.259986e-01	0.279
Activation of AKT2	R-HSA-165158	5.259986e-01	0.279
PTK6 Down-Regulation	R-HSA-8849472	5.259986e-01	0.279
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.161243e-01	0.381
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	3.377720e-01	0.471
PI3K Cascade	R-HSA-109704	4.233279e-01	0.373
RNA Polymerase I Transcription Initiation	R-HSA-73762	4.420566e-01	0.355
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.971146e-01	0.224
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.673160e-01	0.435
Signaling by FGFR in disease	R-HSA-1226099	3.787307e-01	0.422
PIP3 activates AKT signaling	R-HSA-1257604	4.261289e-01	0.370
Extra-nuclear estrogen signaling	R-HSA-9009391	4.173921e-01	0.379
S Phase	R-HSA-69242	1.797637e-01	0.745
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.727404e-01	0.564
Interactions of Rev with host cellular proteins	R-HSA-177243	1.342627e-01	0.872
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.434078e-01	0.843
Signaling by NOTCH3	R-HSA-9012852	3.591838e-01	0.445
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.779895e-01	0.556
DNA Replication	R-HSA-69306	2.873377e-01	0.542
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.395189e-01	0.855
Golgi-to-ER retrograde transport	R-HSA-8856688	5.117156e-01	0.291
G-protein mediated events	R-HSA-112040	1.111988e-01	0.954
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.659259e-01	0.780
PTEN Regulation	R-HSA-6807070	4.005799e-01	0.397
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.940703e-01	0.712
Intracellular signaling by second messengers	R-HSA-9006925	1.676334e-01	0.776
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	2.103625e-01	0.677
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	2.103625e-01	0.677
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.892840e-01	0.723
Lipophagy	R-HSA-9613354	3.659388e-01	0.437
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.259986e-01	0.279
HATs acetylate histones	R-HSA-3214847	2.897442e-01	0.538
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.410415e-01	0.267
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.745715e-01	0.561
DNA Replication Pre-Initiation	R-HSA-69002	3.144576e-01	0.502
Signalling to ERKs	R-HSA-187687	4.638907e-01	0.334
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	4.228613e-01	0.374
Synthesis of DNA	R-HSA-69239	6.151539e-01	0.211
rRNA processing	R-HSA-72312	3.650050e-01	0.438
Signaling by Nuclear Receptors	R-HSA-9006931	5.112963e-01	0.291
Mismatch Repair	R-HSA-5358508	2.322160e-01	0.634
Response of endothelial cells to shear stress	R-HSA-9860931	1.153455e-01	0.938
Membrane Trafficking	R-HSA-199991	1.614143e-01	0.792
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	5.410415e-01	0.267
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.507845e-01	0.455
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.720583e-01	0.764
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.146268e-01	0.941
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.493916e-01	0.603
Acetylcholine regulates insulin secretion	R-HSA-399997	3.878054e-01	0.411
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.802567e-01	0.236
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	4.234580e-01	0.373
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.456820e-01	0.837
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.166977e-01	0.933
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	3.659388e-01	0.437
The NLRP3 inflammasome	R-HSA-844456	4.713419e-01	0.327
Circadian clock	R-HSA-9909396	6.125832e-01	0.213
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.400737e-01	0.468
PERK regulates gene expression	R-HSA-381042	1.659259e-01	0.780
UCH proteinases	R-HSA-5689603	5.389458e-01	0.268
Opioid Signalling	R-HSA-111885	4.540778e-01	0.343
Heme signaling	R-HSA-9707616	4.702047e-01	0.328
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.443545e-01	0.841
Post NMDA receptor activation events	R-HSA-438064	2.308097e-01	0.637
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.034848e-01	0.394
HIV Infection	R-HSA-162906	4.745334e-01	0.324
Formation of editosomes by ADAR proteins	R-HSA-77042	1.920583e-01	0.717
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.351356e-01	0.869
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.351356e-01	0.869
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.737842e-01	0.563
Manipulation of host energy metabolism	R-HSA-9636667	2.737842e-01	0.563
Transport of connexins along the secretory pathway	R-HSA-190827	2.737842e-01	0.563
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.737842e-01	0.563
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.381347e-01	0.860
Unwinding of DNA	R-HSA-176974	1.381347e-01	0.860
mRNA Editing: A to I Conversion	R-HSA-75064	3.472476e-01	0.459
C6 deamination of adenosine	R-HSA-75102	3.472476e-01	0.459
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.472476e-01	0.459
Regulation of KIT signaling	R-HSA-1433559	1.285063e-01	0.891
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	2.493916e-01	0.603
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.164360e-01	0.665
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.132833e-01	0.384
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.275733e-01	0.485
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.742971e-01	0.759
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.659388e-01	0.437
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	3.659388e-01	0.437
Inactivation of CDC42 and RAC1	R-HSA-428543	3.659388e-01	0.437
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.087050e-01	0.680
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.034267e-01	0.394
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.392772e-01	0.621
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.878054e-01	0.411
Budding and maturation of HIV virion	R-HSA-162588	3.604392e-01	0.443
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	3.972505e-01	0.401
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.749627e-01	0.323
Signaling by AMER1 mutants	R-HSA-4839748	4.749627e-01	0.323
PDE3B signalling	R-HSA-165160	5.739594e-01	0.241
PKB-mediated events	R-HSA-109703	5.739594e-01	0.241
ESR-mediated signaling	R-HSA-8939211	2.115086e-01	0.675
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	4.434685e-01	0.353
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.410415e-01	0.267
Viral Messenger RNA Synthesis	R-HSA-168325	4.544659e-01	0.342
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.969821e-01	0.304
FGFR3c ligand binding and activation	R-HSA-190372	5.718468e-01	0.243
GPER1 signaling	R-HSA-9634597	5.499340e-01	0.260
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.626003e-01	0.250
Interleukin-17 signaling	R-HSA-448424	4.516947e-01	0.345
Protein-protein interactions at synapses	R-HSA-6794362	2.000077e-01	0.699
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.973814e-01	0.303
Signaling by EGFR	R-HSA-177929	5.240100e-01	0.281
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.198274e-01	0.377
Ub-specific processing proteases	R-HSA-5689880	4.830294e-01	0.316
HDMs demethylate histones	R-HSA-3214842	2.382737e-01	0.623
Aggrephagy	R-HSA-9646399	5.617682e-01	0.250
Signaling by VEGF	R-HSA-194138	5.273349e-01	0.278
Transcriptional Regulation by VENTX	R-HSA-8853884	1.456820e-01	0.837
Autophagy	R-HSA-9612973	1.259699e-01	0.900
p75NTR signals via NF-kB	R-HSA-193639	6.011198e-01	0.221
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.741243e-01	0.324
Nervous system development	R-HSA-9675108	1.487368e-01	0.828
p75NTR recruits signalling complexes	R-HSA-209543	5.087297e-01	0.294
MAP kinase activation	R-HSA-450294	4.544659e-01	0.342
Early Phase of HIV Life Cycle	R-HSA-162594	5.240621e-01	0.281
Axon guidance	R-HSA-422475	1.736391e-01	0.760
Suppression of apoptosis	R-HSA-9635465	1.892840e-01	0.723
Rap1 signalling	R-HSA-392517	2.550416e-01	0.593
ERK/MAPK targets	R-HSA-198753	3.018605e-01	0.520
Signal attenuation	R-HSA-74749	4.034267e-01	0.394
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	2.983276e-01	0.525
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.940703e-01	0.712
tRNA processing in the nucleus	R-HSA-6784531	4.702047e-01	0.328
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.732524e-01	0.242
Negative regulation of FLT3	R-HSA-9706369	3.591648e-01	0.445
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.067515e-01	0.217
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.972505e-01	0.401
Neurodegenerative Diseases	R-HSA-8863678	3.972505e-01	0.401
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.190871e-01	0.659
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	4.770139e-01	0.321
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.661973e-01	0.779
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.146268e-01	0.941
Specification of the neural plate border	R-HSA-9834899	1.166977e-01	0.933
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.573925e-01	0.589
Activation of AMPA receptors	R-HSA-399710	5.259986e-01	0.279
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.547951e-01	0.450
Transcriptional regulation by small RNAs	R-HSA-5578749	3.507845e-01	0.455
Release of Hh-Np from the secreting cell	R-HSA-5362798	5.739594e-01	0.241
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.739594e-01	0.241
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.236122e-01	0.281
Death Receptor Signaling	R-HSA-73887	2.237199e-01	0.650
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.631031e-01	0.788
Pexophagy	R-HSA-9664873	4.034267e-01	0.394
G1/S Transition	R-HSA-69206	3.284973e-01	0.483
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.886074e-01	0.540
ISG15 antiviral mechanism	R-HSA-1169408	2.760296e-01	0.559
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.675032e-01	0.330
Rab regulation of trafficking	R-HSA-9007101	4.261592e-01	0.370
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	3.812922e-01	0.419
RMTs methylate histone arginines	R-HSA-3214858	1.957540e-01	0.708
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.675032e-01	0.330
Signaling by NTRKs	R-HSA-166520	1.275167e-01	0.894
Kinesins	R-HSA-983189	3.038999e-01	0.517
Selective autophagy	R-HSA-9663891	3.425631e-01	0.465
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.317765e-01	0.635
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	5.325499e-01	0.274
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.399280e-01	0.620
Oligomerization of connexins into connexons	R-HSA-190704	2.737842e-01	0.563
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.103625e-01	0.677
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.132833e-01	0.384
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.275740e-01	0.894
Sensory perception of sour taste	R-HSA-9729555	4.726421e-01	0.325
TNFR1-mediated ceramide production	R-HSA-5626978	4.726421e-01	0.325
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.168001e-01	0.933
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.782932e-01	0.555
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.238081e-01	0.650
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.878054e-01	0.411
Synthesis of PI	R-HSA-1483226	4.398222e-01	0.357
Inositol transporters	R-HSA-429593	5.259986e-01	0.279
Defective pyroptosis	R-HSA-9710421	3.041011e-01	0.517
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.161243e-01	0.381
Tight junction interactions	R-HSA-420029	4.209213e-01	0.376
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.739594e-01	0.241
Signalling to p38 via RIT and RIN	R-HSA-187706	5.739594e-01	0.241
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	4.969821e-01	0.304
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.971146e-01	0.224
Base Excision Repair	R-HSA-73884	2.633743e-01	0.579
L1CAM interactions	R-HSA-373760	5.211653e-01	0.283
Sensory processing of sound	R-HSA-9659379	3.270132e-01	0.485
Formation of definitive endoderm	R-HSA-9823730	4.980522e-01	0.303
Glycolysis	R-HSA-70171	4.051624e-01	0.392
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.962550e-01	0.707
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.146268e-01	0.941
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.106467e-01	0.956
Signaling by ROBO receptors	R-HSA-376176	2.717285e-01	0.566
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.686354e-01	0.433
Protein hydroxylation	R-HSA-9629569	4.980522e-01	0.303
Carnitine shuttle	R-HSA-200425	5.973504e-01	0.224
Diseases of programmed cell death	R-HSA-9645723	3.425631e-01	0.465
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.208620e-01	0.494
Reproduction	R-HSA-1474165	5.918971e-01	0.228
Histamine receptors	R-HSA-390650	4.132833e-01	0.384
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	4.638907e-01	0.334
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	5.737534e-01	0.241
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.190871e-01	0.659
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.750393e-01	0.426
Gastrulation	R-HSA-9758941	6.085208e-01	0.216
Diseases of DNA repair	R-HSA-9675135	5.148906e-01	0.288
Inositol phosphate metabolism	R-HSA-1483249	3.473602e-01	0.459
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	R-HSA-210746	2.493916e-01	0.603
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.674431e-01	0.776
Cation-coupled Chloride cotransporters	R-HSA-426117	2.886074e-01	0.540
Regulation of HMOX1 expression and activity	R-HSA-9707587	4.726421e-01	0.325
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	3.303365e-01	0.481
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.259986e-01	0.279
NrCAM interactions	R-HSA-447038	5.259986e-01	0.279
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.047750e-01	0.393
Sodium-coupled phosphate cotransporters	R-HSA-427652	5.739594e-01	0.241
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.973504e-01	0.224
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.961348e-01	0.529
Cleavage of the damaged purine	R-HSA-110331	5.040025e-01	0.298
Apoptosis	R-HSA-109581	2.189889e-01	0.660
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.034267e-01	0.394
STING mediated induction of host immune responses	R-HSA-1834941	4.713419e-01	0.327
Depurination	R-HSA-73927	5.236122e-01	0.281
Activation of BH3-only proteins	R-HSA-114452	5.345580e-01	0.272
FLT3 Signaling	R-HSA-9607240	4.047750e-01	0.393
Programmed Cell Death	R-HSA-5357801	2.945043e-01	0.531
Influenza Infection	R-HSA-168255	5.393015e-01	0.268
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.472476e-01	0.459
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.303365e-01	0.481
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.398222e-01	0.357
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.259986e-01	0.279
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.749627e-01	0.323
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.812922e-01	0.419
Co-inhibition by CTLA4	R-HSA-389513	4.980522e-01	0.303
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	5.410415e-01	0.267
Signal regulatory protein family interactions	R-HSA-391160	5.718468e-01	0.243
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.011198e-01	0.221
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.011198e-01	0.221
G-protein beta:gamma signalling	R-HSA-397795	5.971146e-01	0.224
Transcriptional Regulation by NPAS4	R-HSA-9634815	4.574027e-01	0.340
DNA Damage Reversal	R-HSA-73942	6.011198e-01	0.221
Growth hormone receptor signaling	R-HSA-982772	3.734240e-01	0.428
RET signaling	R-HSA-8853659	1.797319e-01	0.745
Apoptosis induced DNA fragmentation	R-HSA-140342	4.034267e-01	0.394
Josephin domain DUBs	R-HSA-5689877	4.034267e-01	0.394
Signaling by PDGFR in disease	R-HSA-9671555	5.493117e-01	0.260
Signaling by Leptin	R-HSA-2586552	1.631031e-01	0.788
ChREBP activates metabolic gene expression	R-HSA-163765	4.398222e-01	0.357
Regulation of beta-cell development	R-HSA-186712	4.227689e-01	0.374
Cleavage of the damaged pyrimidine	R-HSA-110329	4.420566e-01	0.355
G0 and Early G1	R-HSA-1538133	5.768218e-01	0.239
Depyrimidination	R-HSA-73928	4.420566e-01	0.355
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	2.751830e-01	0.560
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.739594e-01	0.241
NPAS4 regulates expression of target genes	R-HSA-9768919	4.434685e-01	0.353
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.737534e-01	0.241
OAS antiviral response	R-HSA-8983711	5.087297e-01	0.294
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.479791e-01	0.606
HDL assembly	R-HSA-8963896	5.718468e-01	0.243
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	5.167168e-01	0.287
Interleukin-37 signaling	R-HSA-9008059	5.345580e-01	0.272
Assembly of Viral Components at the Budding Site	R-HSA-168316	5.259986e-01	0.279
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	5.737534e-01	0.241
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.159365e-01	0.210
Erythropoietin activates STAT5	R-HSA-9027283	6.170700e-01	0.210
Autointegration results in viral DNA circles	R-HSA-177539	6.170700e-01	0.210
G2/M DNA replication checkpoint	R-HSA-69478	6.170700e-01	0.210
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.170700e-01	0.210
NADPH regeneration	R-HSA-389542	6.170700e-01	0.210
Nef and signal transduction	R-HSA-164944	6.170700e-01	0.210
trans-Golgi Network Vesicle Budding	R-HSA-199992	6.187771e-01	0.208
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.200756e-01	0.208
Signaling by TGFB family members	R-HSA-9006936	6.208154e-01	0.207
KEAP1-NFE2L2 pathway	R-HSA-9755511	6.276398e-01	0.202
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.288551e-01	0.201
Killing mechanisms	R-HSA-9664420	6.288551e-01	0.201
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.288551e-01	0.201
Class I peroxisomal membrane protein import	R-HSA-9603798	6.288551e-01	0.201
Differentiation of T cells	R-HSA-9945266	6.288551e-01	0.201
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.288551e-01	0.201
Regulation of BACH1 activity	R-HSA-9708530	6.288551e-01	0.201
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.288551e-01	0.201
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.288551e-01	0.201
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.288551e-01	0.201
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	6.306452e-01	0.200
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	6.306452e-01	0.200
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	6.306452e-01	0.200
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.319830e-01	0.199
Switching of origins to a post-replicative state	R-HSA-69052	6.324004e-01	0.199
Signaling by FGFR4	R-HSA-5654743	6.330904e-01	0.199
Signaling by SCF-KIT	R-HSA-1433557	6.330904e-01	0.199
RAF activation	R-HSA-5673000	6.358994e-01	0.197
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	6.358994e-01	0.197
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.358994e-01	0.197
Mitophagy	R-HSA-5205647	6.358994e-01	0.197
Mitochondrial biogenesis	R-HSA-1592230	6.391821e-01	0.194
Glucose metabolism	R-HSA-70326	6.391821e-01	0.194
Glycogen breakdown (glycogenolysis)	R-HSA-70221	6.419107e-01	0.193
Acyl chain remodelling of PS	R-HSA-1482801	6.419107e-01	0.193
Interleukin-7 signaling	R-HSA-1266695	6.419107e-01	0.193
Insulin receptor signalling cascade	R-HSA-74751	6.461137e-01	0.190
Eukaryotic Translation Elongation	R-HSA-156842	6.465282e-01	0.189
Protein folding	R-HSA-391251	6.465282e-01	0.189
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.473008e-01	0.189
Cell junction organization	R-HSA-446728	6.491372e-01	0.188
G1 Phase	R-HSA-69236	6.497670e-01	0.187
Cyclin D associated events in G1	R-HSA-69231	6.497670e-01	0.187
EPHB-mediated forward signaling	R-HSA-3928662	6.497670e-01	0.187
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.550641e-01	0.184
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.558206e-01	0.183
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.558206e-01	0.183
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.558206e-01	0.183
Disinhibition of SNARE formation	R-HSA-114516	6.558206e-01	0.183
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.558206e-01	0.183
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.558206e-01	0.183
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.558206e-01	0.183
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.558206e-01	0.183
VLDL clearance	R-HSA-8964046	6.558206e-01	0.183
Regulation of PTEN localization	R-HSA-8948747	6.558206e-01	0.183
Phase 3 - rapid repolarisation	R-HSA-5576890	6.558206e-01	0.183
CHL1 interactions	R-HSA-447041	6.558206e-01	0.183
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.558206e-01	0.183
Maturation of replicase proteins	R-HSA-9694301	6.558206e-01	0.183
Assembly of the pre-replicative complex	R-HSA-68867	6.582786e-01	0.182
MAPK6/MAPK4 signaling	R-HSA-5687128	6.583045e-01	0.182
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	6.628454e-01	0.179
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	6.628454e-01	0.179
Metalloprotease DUBs	R-HSA-5689901	6.628454e-01	0.179
Interleukin-12 signaling	R-HSA-9020591	6.716000e-01	0.173
FGFR2 mutant receptor activation	R-HSA-1839126	6.721759e-01	0.173
tRNA modification in the nucleus and cytosol	R-HSA-6782315	6.735945e-01	0.172
Signaling by EGFRvIII in Cancer	R-HSA-5637812	6.797717e-01	0.168
Constitutive Signaling by EGFRvIII	R-HSA-5637810	6.797717e-01	0.168
Regulation of NPAS4 gene expression	R-HSA-9768759	6.797717e-01	0.168
Specification of primordial germ cells	R-HSA-9827857	6.797717e-01	0.168
Signaling by TGFBR3	R-HSA-9839373	6.816463e-01	0.166
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.828763e-01	0.166
RNA Polymerase I Promoter Opening	R-HSA-73728	6.828763e-01	0.166
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	6.828763e-01	0.166
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.858542e-01	0.164
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.868238e-01	0.163
Type I hemidesmosome assembly	R-HSA-446107	6.906518e-01	0.161
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	6.906518e-01	0.161
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.906518e-01	0.161
Activation of RAS in B cells	R-HSA-1169092	6.906518e-01	0.161
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.906518e-01	0.161
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.906518e-01	0.161
FGFR1b ligand binding and activation	R-HSA-190370	6.906518e-01	0.161
MET receptor recycling	R-HSA-8875656	6.906518e-01	0.161
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.906518e-01	0.161
Regulation by c-FLIP	R-HSA-3371378	6.906518e-01	0.161
Dimerization of procaspase-8	R-HSA-69416	6.906518e-01	0.161
SLC-mediated bile acid transport	R-HSA-9958517	6.906518e-01	0.161
Sodium/Proton exchangers	R-HSA-425986	6.906518e-01	0.161
Adrenoceptors	R-HSA-390696	6.906518e-01	0.161
Eukaryotic Translation Termination	R-HSA-72764	6.921616e-01	0.160
Interleukin-12 family signaling	R-HSA-447115	6.938454e-01	0.159
Maternal to zygotic transition (MZT)	R-HSA-9816359	6.996233e-01	0.155
MHC class II antigen presentation	R-HSA-2132295	6.996233e-01	0.155
Inflammasomes	R-HSA-622312	7.020060e-01	0.154
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.020060e-01	0.154
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	7.029844e-01	0.153
COPI-mediated anterograde transport	R-HSA-6807878	7.029844e-01	0.153
FOXO-mediated transcription of cell death genes	R-HSA-9614657	7.030133e-01	0.153
Signaling by ERBB2 ECD mutants	R-HSA-9665348	7.030133e-01	0.153
Ephrin signaling	R-HSA-3928664	7.030133e-01	0.153
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.030133e-01	0.153
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	7.030133e-01	0.153
Synaptic adhesion-like molecules	R-HSA-8849932	7.030133e-01	0.153
GAB1 signalosome	R-HSA-180292	7.030133e-01	0.153
Regulation of TP53 Activity through Methylation	R-HSA-6804760	7.030133e-01	0.153
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	7.030133e-01	0.153
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.030133e-01	0.153
Peptide chain elongation	R-HSA-156902	7.051631e-01	0.152
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.058750e-01	0.151
Cell-Cell communication	R-HSA-1500931	7.064209e-01	0.151
Peroxisomal protein import	R-HSA-9033241	7.178445e-01	0.144
Signaling by MET	R-HSA-6806834	7.197241e-01	0.143
PKR-mediated signaling	R-HSA-9833482	7.197241e-01	0.143
Regulation of CDH11 Expression and Function	R-HSA-9759475	7.202423e-01	0.143
Regulation of gene expression in beta cells	R-HSA-210745	7.202423e-01	0.143
Gene Silencing by RNA	R-HSA-211000	7.215300e-01	0.142
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	7.219600e-01	0.141
CASP8 activity is inhibited	R-HSA-5218900	7.219600e-01	0.141
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.219600e-01	0.141
Calcineurin activates NFAT	R-HSA-2025928	7.219600e-01	0.141
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.219600e-01	0.141
p75NTR regulates axonogenesis	R-HSA-193697	7.219600e-01	0.141
mRNA Editing	R-HSA-75072	7.219600e-01	0.141
Regulation of CDH11 gene transcription	R-HSA-9762293	7.219600e-01	0.141
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.219600e-01	0.141
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.219600e-01	0.141
Cellular response to mitochondrial stress	R-HSA-9840373	7.219600e-01	0.141
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.219600e-01	0.141
Post-translational protein phosphorylation	R-HSA-8957275	7.239016e-01	0.140
MyD88 cascade initiated on plasma membrane	R-HSA-975871	7.239016e-01	0.140
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	7.239016e-01	0.140
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	7.239016e-01	0.140
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.244063e-01	0.140
Cyclin E associated events during G1/S transition	R-HSA-69202	7.244063e-01	0.140
Regulation of signaling by CBL	R-HSA-912631	7.248326e-01	0.140
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.248326e-01	0.140
Translesion Synthesis by POLH	R-HSA-110320	7.248326e-01	0.140
HCMV Infection	R-HSA-9609646	7.255166e-01	0.139
Stimuli-sensing channels	R-HSA-2672351	7.312512e-01	0.136
FOXO-mediated transcription	R-HSA-9614085	7.339913e-01	0.134
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.369851e-01	0.133
Glycogen metabolism	R-HSA-8982491	7.369851e-01	0.133
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	7.374804e-01	0.132
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.390117e-01	0.131
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.390117e-01	0.131
Signaling by FGFR2 in disease	R-HSA-5655253	7.393523e-01	0.131
Aquaporin-mediated transport	R-HSA-445717	7.431521e-01	0.129
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.452792e-01	0.128
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.452792e-01	0.128
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.452792e-01	0.128
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.452792e-01	0.128
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.452792e-01	0.128
PI-3K cascade:FGFR4	R-HSA-5654720	7.452792e-01	0.128
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	7.476802e-01	0.126
MET activates RAP1 and RAC1	R-HSA-8875555	7.501012e-01	0.125
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.501012e-01	0.125
Binding and entry of HIV virion	R-HSA-173107	7.501012e-01	0.125
DNA replication initiation	R-HSA-68952	7.501012e-01	0.125
EGFR Transactivation by Gastrin	R-HSA-2179392	7.501012e-01	0.125
Arachidonate production from DAG	R-HSA-426048	7.501012e-01	0.125
2-LTR circle formation	R-HSA-164843	7.501012e-01	0.125
Interleukin-27 signaling	R-HSA-9020956	7.501012e-01	0.125
Receptor Mediated Mitophagy	R-HSA-8934903	7.501012e-01	0.125
Maturation of spike protein	R-HSA-9683686	7.501012e-01	0.125
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.501012e-01	0.125
Regulation of CDH11 function	R-HSA-9762292	7.501012e-01	0.125
Integration of energy metabolism	R-HSA-163685	7.514826e-01	0.124
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	7.515789e-01	0.124
Meiotic recombination	R-HSA-912446	7.525108e-01	0.123
Cargo concentration in the ER	R-HSA-5694530	7.540882e-01	0.123
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.551772e-01	0.122
G2/M Transition	R-HSA-69275	7.600015e-01	0.119
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	7.629033e-01	0.118
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.644076e-01	0.117
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.644076e-01	0.117
Zygotic genome activation (ZGA)	R-HSA-9819196	7.644076e-01	0.117
Orc1 removal from chromatin	R-HSA-68949	7.651672e-01	0.116
ER to Golgi Anterograde Transport	R-HSA-199977	7.654079e-01	0.116
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.655419e-01	0.116
HIV Transcription Initiation	R-HSA-167161	7.655419e-01	0.116
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.655419e-01	0.116
Signaling by FGFR1 in disease	R-HSA-5655302	7.655419e-01	0.116
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.699727e-01	0.114
Mitotic G2-G2/M phases	R-HSA-453274	7.736702e-01	0.111
Signaling by WNT	R-HSA-195721	7.742932e-01	0.111
PECAM1 interactions	R-HSA-210990	7.753956e-01	0.110
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.753956e-01	0.110
FGFR2b ligand binding and activation	R-HSA-190377	7.753956e-01	0.110
vRNA Synthesis	R-HSA-192814	7.753956e-01	0.110
Bicarbonate transporters	R-HSA-425381	7.753956e-01	0.110
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.753956e-01	0.110
Smooth Muscle Contraction	R-HSA-445355	7.773269e-01	0.109
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.788842e-01	0.109
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.788842e-01	0.109
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	7.807027e-01	0.108
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.845558e-01	0.105
FGFR1 mutant receptor activation	R-HSA-1839124	7.845558e-01	0.105
Regulation of necroptotic cell death	R-HSA-5675482	7.845558e-01	0.105
Assembly of the ORC complex at the origin of replication	R-HSA-68616	7.845558e-01	0.105
Co-inhibition by PD-1	R-HSA-389948	7.854707e-01	0.105
Adipogenesis	R-HSA-9843745	7.856447e-01	0.105
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.858112e-01	0.105
Signaling by NOTCH	R-HSA-157118	7.876363e-01	0.104
Cellular response to hypoxia	R-HSA-1234174	7.887647e-01	0.103
RNA Polymerase II Promoter Escape	R-HSA-73776	7.916177e-01	0.101
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.916177e-01	0.101
TBC/RABGAPs	R-HSA-8854214	7.916177e-01	0.101
Response of Mtb to phagocytosis	R-HSA-9637690	7.916177e-01	0.101
Cell-cell junction organization	R-HSA-421270	7.925945e-01	0.101
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.962133e-01	0.099
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.976447e-01	0.098
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.981311e-01	0.098
Endosomal/Vacuolar pathway	R-HSA-1236977	7.981311e-01	0.098
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.981311e-01	0.098
Integration of provirus	R-HSA-162592	7.981311e-01	0.098
Signaling by activated point mutants of FGFR1	R-HSA-1839122	7.981311e-01	0.098
NF-kB is activated and signals survival	R-HSA-209560	7.981311e-01	0.098
Plasmalogen biosynthesis	R-HSA-75896	7.981311e-01	0.098
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.981311e-01	0.098
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.981311e-01	0.098
Anchoring fibril formation	R-HSA-2214320	7.981311e-01	0.098
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.985791e-01	0.098
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.989406e-01	0.097
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.989406e-01	0.097
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.989406e-01	0.097
PI-3K cascade:FGFR1	R-HSA-5654689	7.989406e-01	0.097
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.989406e-01	0.097
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.001839e-01	0.097
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.023852e-01	0.096
Netrin-1 signaling	R-HSA-373752	8.037559e-01	0.095
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	8.043766e-01	0.095
Vesicle-mediated transport	R-HSA-5653656	8.045503e-01	0.094
Signaling by FGFR1	R-HSA-5654736	8.108979e-01	0.091
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.118295e-01	0.091
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.118295e-01	0.091
Signaling by NOTCH2	R-HSA-1980145	8.118295e-01	0.091
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.144647e-01	0.089
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	8.144647e-01	0.089
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.144647e-01	0.089
Organic anion transport by SLCO transporters	R-HSA-879518	8.144647e-01	0.089
Syndecan interactions	R-HSA-3000170	8.144647e-01	0.089
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.153134e-01	0.089
Fanconi Anemia Pathway	R-HSA-6783310	8.153134e-01	0.089
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.185664e-01	0.087
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.185664e-01	0.087
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.185664e-01	0.087
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.185664e-01	0.087
SHC-related events triggered by IGF1R	R-HSA-2428933	8.185664e-01	0.087
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.185664e-01	0.087
Signaling by LTK	R-HSA-9842663	8.185664e-01	0.087
Polymerase switching	R-HSA-69091	8.185664e-01	0.087
Leading Strand Synthesis	R-HSA-69109	8.185664e-01	0.087
Regulation of IFNG signaling	R-HSA-877312	8.185664e-01	0.087
VLDLR internalisation and degradation	R-HSA-8866427	8.185664e-01	0.087
MET activates RAS signaling	R-HSA-8851805	8.185664e-01	0.087
Interleukin-35 Signalling	R-HSA-8984722	8.185664e-01	0.087
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.185664e-01	0.087
Interleukin-15 signaling	R-HSA-8983432	8.185664e-01	0.087
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	8.187156e-01	0.087
Regulation of insulin secretion	R-HSA-422356	8.195409e-01	0.086
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.211482e-01	0.086
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	8.212222e-01	0.086
Oncogene Induced Senescence	R-HSA-2559585	8.243342e-01	0.084
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.263060e-01	0.083
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.263060e-01	0.083
MyD88 dependent cascade initiated on endosome	R-HSA-975155	8.286011e-01	0.082
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	8.289074e-01	0.081
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	8.289074e-01	0.081
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.289074e-01	0.081
TRAF6 mediated NF-kB activation	R-HSA-933542	8.289074e-01	0.081
TNFs bind their physiological receptors	R-HSA-5669034	8.289074e-01	0.081
Plasma lipoprotein assembly	R-HSA-8963898	8.289074e-01	0.081
Adherens junctions interactions	R-HSA-418990	8.352683e-01	0.078
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.357445e-01	0.078
MyD88-independent TLR4 cascade	R-HSA-166166	8.357445e-01	0.078
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.361214e-01	0.078
Triglyceride catabolism	R-HSA-163560	8.361214e-01	0.078
G1/S-Specific Transcription	R-HSA-69205	8.361214e-01	0.078
Degradation of beta-catenin by the destruction complex	R-HSA-195253	8.367474e-01	0.077
Recycling pathway of L1	R-HSA-437239	8.367502e-01	0.077
FGFR2c ligand binding and activation	R-HSA-190375	8.369341e-01	0.077
Platelet Adhesion to exposed collagen	R-HSA-75892	8.369341e-01	0.077
FGFR1c ligand binding and activation	R-HSA-190373	8.369341e-01	0.077
Processing of SMDT1	R-HSA-8949664	8.369341e-01	0.077
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.369341e-01	0.077
FGFR4 ligand binding and activation	R-HSA-190322	8.369341e-01	0.077
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.369341e-01	0.077
Reversible hydration of carbon dioxide	R-HSA-1475029	8.369341e-01	0.077
rRNA modification in the mitochondrion	R-HSA-6793080	8.369341e-01	0.077
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.369341e-01	0.077
Maturation of nucleoprotein	R-HSA-9683610	8.369341e-01	0.077
Interleukin-6 signaling	R-HSA-1059683	8.369341e-01	0.077
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.369341e-01	0.077
Selenocysteine synthesis	R-HSA-2408557	8.420612e-01	0.075
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.423287e-01	0.075
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.423287e-01	0.075
PI-3K cascade:FGFR2	R-HSA-5654695	8.423287e-01	0.075
Formation of the nephric duct	R-HSA-9830364	8.423287e-01	0.075
Gluconeogenesis	R-HSA-70263	8.466632e-01	0.072
TRAF6 mediated IRF7 activation	R-HSA-933541	8.472200e-01	0.072
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	8.472200e-01	0.072
Collagen chain trimerization	R-HSA-8948216	8.472200e-01	0.072
Signaling by Insulin receptor	R-HSA-74752	8.494403e-01	0.071
Cytoprotection by HMOX1	R-HSA-9707564	8.507322e-01	0.070
tRNA processing	R-HSA-72306	8.527149e-01	0.069
Developmental Lineages of the Mammary Gland	R-HSA-9924644	8.533049e-01	0.069
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.534433e-01	0.069
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.534433e-01	0.069
CRMPs in Sema3A signaling	R-HSA-399956	8.534433e-01	0.069
Signaling by FGFR4 in disease	R-HSA-5655291	8.534433e-01	0.069
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.534433e-01	0.069
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	8.534433e-01	0.069
Retrograde neurotrophin signalling	R-HSA-177504	8.534433e-01	0.069
NRIF signals cell death from the nucleus	R-HSA-205043	8.534433e-01	0.069
Prolactin receptor signaling	R-HSA-1170546	8.534433e-01	0.069
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.534433e-01	0.069
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.534433e-01	0.069
MET activates PTK2 signaling	R-HSA-8874081	8.547872e-01	0.068
Signaling by EGFR in Cancer	R-HSA-1643713	8.547872e-01	0.068
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.547872e-01	0.068
TRP channels	R-HSA-3295583	8.547872e-01	0.068
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.547872e-01	0.068
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.557960e-01	0.068
Viral mRNA Translation	R-HSA-192823	8.558083e-01	0.068
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.560630e-01	0.067
MET promotes cell motility	R-HSA-8875878	8.576589e-01	0.067
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.576589e-01	0.067
Formation of paraxial mesoderm	R-HSA-9793380	8.577345e-01	0.067
Ca2+ pathway	R-HSA-4086398	8.610529e-01	0.065
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.632975e-01	0.064
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.650640e-01	0.063
NCAM signaling for neurite out-growth	R-HSA-375165	8.658371e-01	0.063
Signaling by ALK	R-HSA-201556	8.674676e-01	0.062
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.680521e-01	0.061
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.682820e-01	0.061
Erythropoietin activates RAS	R-HSA-9027284	8.682820e-01	0.061
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.682820e-01	0.061
RNA Polymerase III Chain Elongation	R-HSA-73780	8.682820e-01	0.061
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.682820e-01	0.061
Translesion synthesis by REV1	R-HSA-110312	8.682820e-01	0.061
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.682820e-01	0.061
Biotin transport and metabolism	R-HSA-196780	8.682820e-01	0.061
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	8.682820e-01	0.061
p38MAPK events	R-HSA-171007	8.682820e-01	0.061
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.682820e-01	0.061
Other semaphorin interactions	R-HSA-416700	8.682820e-01	0.061
Signaling by NOTCH4	R-HSA-9013694	8.684595e-01	0.061
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.738590e-01	0.059
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.755345e-01	0.058
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	8.761022e-01	0.057
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.766749e-01	0.057
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.766749e-01	0.057
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.770435e-01	0.057
Pyroptosis	R-HSA-5620971	8.770435e-01	0.057
SARS-CoV-2-host interactions	R-HSA-9705683	8.808251e-01	0.055
Translesion synthesis by POLI	R-HSA-5656121	8.816190e-01	0.055
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.816190e-01	0.055
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.816190e-01	0.055
Induction of Cell-Cell Fusion	R-HSA-9733458	8.816190e-01	0.055
Fructose catabolism	R-HSA-70350	8.816190e-01	0.055
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	8.816190e-01	0.055
Activation of SMO	R-HSA-5635838	8.816190e-01	0.055
Regulation of NF-kappa B signaling	R-HSA-9758274	8.816190e-01	0.055
Atorvastatin ADME	R-HSA-9754706	8.816190e-01	0.055
Virus Assembly and Release	R-HSA-168268	8.816190e-01	0.055
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.853098e-01	0.053
Signaling by ERBB2 KD Mutants	R-HSA-9664565	8.869504e-01	0.052
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	8.888946e-01	0.051
Regulation of PTEN stability and activity	R-HSA-8948751	8.888946e-01	0.051
Intra-Golgi traffic	R-HSA-6811438	8.934007e-01	0.049
Negative regulation of MAPK pathway	R-HSA-5675221	8.934007e-01	0.049
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.936063e-01	0.049
Translesion synthesis by POLK	R-HSA-5655862	8.936063e-01	0.049
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	8.936063e-01	0.049
Phase 2 - plateau phase	R-HSA-5576893	8.936063e-01	0.049
TRAF3-dependent IRF activation pathway	R-HSA-918233	8.936063e-01	0.049
Fibronectin matrix formation	R-HSA-1566977	8.936063e-01	0.049
Synthesis of PG	R-HSA-1483148	8.936063e-01	0.049
tRNA modification in the mitochondrion	R-HSA-6787450	8.936063e-01	0.049
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.936063e-01	0.049
Cellular response to starvation	R-HSA-9711097	8.937089e-01	0.049
Signaling by ERBB2 in Cancer	R-HSA-1227990	8.961126e-01	0.048
Downstream signaling of activated FGFR4	R-HSA-5654716	8.961126e-01	0.048
SHC1 events in ERBB2 signaling	R-HSA-1250196	8.961126e-01	0.048
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.998594e-01	0.046
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.998594e-01	0.046
Cytosolic tRNA aminoacylation	R-HSA-379716	9.009752e-01	0.045
G alpha (z) signalling events	R-HSA-418597	9.027079e-01	0.044
PI3K events in ERBB2 signaling	R-HSA-1963642	9.043804e-01	0.044
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.043804e-01	0.044
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.043804e-01	0.044
Glycogen storage diseases	R-HSA-3229121	9.043804e-01	0.044
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.043804e-01	0.044
Regulation of FZD by ubiquitination	R-HSA-4641263	9.043804e-01	0.044
Choline catabolism	R-HSA-6798163	9.043804e-01	0.044
Uptake and function of anthrax toxins	R-HSA-5210891	9.043804e-01	0.044
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.043804e-01	0.044
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.045792e-01	0.044
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.045792e-01	0.044
Downstream signal transduction	R-HSA-186763	9.045792e-01	0.044
Regulation of T cell activation by CD28 family	R-HSA-388841	9.052712e-01	0.043
Regulated Necrosis	R-HSA-5218859	9.066731e-01	0.043
Organelle biogenesis and maintenance	R-HSA-1852241	9.071542e-01	0.042
TNF signaling	R-HSA-75893	9.090277e-01	0.041
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.090277e-01	0.041
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.123051e-01	0.040
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.123971e-01	0.040
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.132017e-01	0.039
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.132017e-01	0.039
G beta:gamma signalling through PLC beta	R-HSA-418217	9.140641e-01	0.039
Transport of connexons to the plasma membrane	R-HSA-190872	9.140641e-01	0.039
Activated point mutants of FGFR2	R-HSA-2033519	9.140641e-01	0.039
FGFR1 ligand binding and activation	R-HSA-190242	9.140641e-01	0.039
Presynaptic function of Kainate receptors	R-HSA-500657	9.140641e-01	0.039
Chaperone Mediated Autophagy	R-HSA-9613829	9.140641e-01	0.039
Platelet sensitization by LDL	R-HSA-432142	9.140641e-01	0.039
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.140641e-01	0.039
Tie2 Signaling	R-HSA-210993	9.140641e-01	0.039
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.173017e-01	0.037
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	9.176364e-01	0.037
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	9.196109e-01	0.036
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.196487e-01	0.036
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.205819e-01	0.036
Somitogenesis	R-HSA-9824272	9.208681e-01	0.036
Host Interactions of HIV factors	R-HSA-162909	9.212362e-01	0.036
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.226797e-01	0.035
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.227675e-01	0.035
Crosslinking of collagen fibrils	R-HSA-2243919	9.227675e-01	0.035
Germ layer formation at gastrulation	R-HSA-9754189	9.227675e-01	0.035
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.227675e-01	0.035
Diseases of hemostasis	R-HSA-9671793	9.227675e-01	0.035
Other interleukin signaling	R-HSA-449836	9.227675e-01	0.035
Maturation of nucleoprotein	R-HSA-9694631	9.227675e-01	0.035
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.227675e-01	0.035
PPARA activates gene expression	R-HSA-1989781	9.246617e-01	0.034
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.258505e-01	0.033
Resolution of D-Loop Structures	R-HSA-5693537	9.262626e-01	0.033
Miscellaneous transport and binding events	R-HSA-5223345	9.262626e-01	0.033
Heme degradation	R-HSA-189483	9.262626e-01	0.033
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.266406e-01	0.033
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.266406e-01	0.033
Condensation of Prophase Chromosomes	R-HSA-2299718	9.266406e-01	0.033
Regulation of TNFR1 signaling	R-HSA-5357905	9.266406e-01	0.033
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.266406e-01	0.033
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.305900e-01	0.031
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.305900e-01	0.031
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	9.305900e-01	0.031
Glycogen synthesis	R-HSA-3322077	9.305900e-01	0.031
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.305900e-01	0.031
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.305900e-01	0.031
Pregnenolone biosynthesis	R-HSA-196108	9.305900e-01	0.031
Signal transduction by L1	R-HSA-445144	9.305900e-01	0.031
Signaling by NODAL	R-HSA-1181150	9.305900e-01	0.031
Nephrin family interactions	R-HSA-373753	9.305900e-01	0.031
tRNA Aminoacylation	R-HSA-379724	9.308022e-01	0.031
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.311161e-01	0.031
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.320242e-01	0.031
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.320242e-01	0.031
Synthesis of PC	R-HSA-1483191	9.320242e-01	0.031
Cilium Assembly	R-HSA-5617833	9.323177e-01	0.030
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.323921e-01	0.030
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	9.323921e-01	0.030
Calnexin/calreticulin cycle	R-HSA-901042	9.323921e-01	0.030
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.323921e-01	0.030
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.346409e-01	0.029
Interferon Signaling	R-HSA-913531	9.346409e-01	0.029
Platelet degranulation	R-HSA-114608	9.354154e-01	0.029
Co-stimulation by CD28	R-HSA-389356	9.370416e-01	0.028
TNFR1-induced proapoptotic signaling	R-HSA-5357786	9.376205e-01	0.028
FGFR2 ligand binding and activation	R-HSA-190241	9.376205e-01	0.028
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.376205e-01	0.028
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.376205e-01	0.028
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.376205e-01	0.028
Phenylalanine metabolism	R-HSA-8964208	9.376205e-01	0.028
Basigin interactions	R-HSA-210991	9.376205e-01	0.028
Signalling to RAS	R-HSA-167044	9.376205e-01	0.028
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.377629e-01	0.028
Cellular response to chemical stress	R-HSA-9711123	9.379381e-01	0.028
Downstream signaling of activated FGFR1	R-HSA-5654687	9.380369e-01	0.028
Downstream signaling of activated FGFR2	R-HSA-5654696	9.380369e-01	0.028
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.380369e-01	0.028
Transferrin endocytosis and recycling	R-HSA-917977	9.380369e-01	0.028
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.382630e-01	0.028
Mitochondrial protein import	R-HSA-1268020	9.398180e-01	0.027
Signaling by PDGF	R-HSA-186797	9.398180e-01	0.027
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.405944e-01	0.027
Gap junction trafficking and regulation	R-HSA-157858	9.417147e-01	0.026
Parasitic Infection Pathways	R-HSA-9824443	9.426134e-01	0.026
Leishmania infection	R-HSA-9658195	9.426134e-01	0.026
Lysosome Vesicle Biogenesis	R-HSA-432720	9.432323e-01	0.025
GPVI-mediated activation cascade	R-HSA-114604	9.432323e-01	0.025
FLT3 signaling in disease	R-HSA-9682385	9.432323e-01	0.025
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.439393e-01	0.025
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	9.439393e-01	0.025
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.439393e-01	0.025
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.439393e-01	0.025
Listeria monocytogenes entry into host cells	R-HSA-8876384	9.439393e-01	0.025
Mitochondrial calcium ion transport	R-HSA-8949215	9.439393e-01	0.025
Ribavirin ADME	R-HSA-9755088	9.439393e-01	0.025
Assembly Of The HIV Virion	R-HSA-175474	9.439393e-01	0.025
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.439393e-01	0.025
Leishmania phagocytosis	R-HSA-9664417	9.454143e-01	0.024
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.454143e-01	0.024
Parasite infection	R-HSA-9664407	9.454143e-01	0.024
Voltage gated Potassium channels	R-HSA-1296072	9.480114e-01	0.023
Degradation of DVL	R-HSA-4641258	9.480114e-01	0.023
NCAM1 interactions	R-HSA-419037	9.480114e-01	0.023
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.480114e-01	0.023
Ovarian tumor domain proteases	R-HSA-5689896	9.480114e-01	0.023
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.480647e-01	0.023
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.496184e-01	0.022
Fructose metabolism	R-HSA-5652084	9.496184e-01	0.022
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	9.496184e-01	0.022
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.496184e-01	0.022
LDL clearance	R-HSA-8964038	9.496184e-01	0.022
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.501105e-01	0.022
Hedgehog ligand biogenesis	R-HSA-5358346	9.501105e-01	0.022
The phototransduction cascade	R-HSA-2514856	9.501105e-01	0.022
Integrin cell surface interactions	R-HSA-216083	9.509265e-01	0.022
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.524052e-01	0.021
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.538721e-01	0.021
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.538721e-01	0.021
Regulation of PTEN mRNA translation	R-HSA-8943723	9.547225e-01	0.020
Formation of the ureteric bud	R-HSA-9830674	9.547225e-01	0.020
Free fatty acids regulate insulin secretion	R-HSA-400451	9.547225e-01	0.020
Interleukin receptor SHC signaling	R-HSA-912526	9.547225e-01	0.020
Mitochondrial mRNA modification	R-HSA-9937008	9.547225e-01	0.020
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.547225e-01	0.020
PI Metabolism	R-HSA-1483255	9.559323e-01	0.020
Stabilization of p53	R-HSA-69541	9.564427e-01	0.019
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.564427e-01	0.019
Plasma lipoprotein clearance	R-HSA-8964043	9.564427e-01	0.019
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.573671e-01	0.019
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.593097e-01	0.018
Synthesis of dolichyl-phosphate	R-HSA-446199	9.593097e-01	0.018
Mitochondrial RNA degradation	R-HSA-9836573	9.593097e-01	0.018
Complex III assembly	R-HSA-9865881	9.593097e-01	0.018
Interleukin-6 family signaling	R-HSA-6783589	9.593097e-01	0.018
HCMV Late Events	R-HSA-9610379	9.601293e-01	0.018
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.601509e-01	0.018
Generation of second messenger molecules	R-HSA-202433	9.601509e-01	0.018
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.601509e-01	0.018
Nuclear signaling by ERBB4	R-HSA-1251985	9.601509e-01	0.018
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.601509e-01	0.018
Interleukin-2 family signaling	R-HSA-451927	9.601509e-01	0.018
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.606126e-01	0.017
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.606126e-01	0.017
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.634325e-01	0.016
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.634325e-01	0.016
Long-term potentiation	R-HSA-9620244	9.634325e-01	0.016
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.634325e-01	0.016
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.634325e-01	0.016
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.634325e-01	0.016
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.635551e-01	0.016
Maturation of spike protein	R-HSA-9694548	9.635551e-01	0.016
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.636249e-01	0.016
SARS-CoV-2 Infection	R-HSA-9694516	9.649417e-01	0.015
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	9.664192e-01	0.015
Ion homeostasis	R-HSA-5578775	9.664192e-01	0.015
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.666789e-01	0.015
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.666789e-01	0.015
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.666789e-01	0.015
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.666789e-01	0.015
Translation of Structural Proteins	R-HSA-9683701	9.666789e-01	0.015
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.670467e-01	0.015
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.671377e-01	0.015
Signaling by FLT3 fusion proteins	R-HSA-9703465	9.671377e-01	0.015
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.671377e-01	0.015
Sphingolipid catabolism	R-HSA-9845614	9.671377e-01	0.015
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.671377e-01	0.015
Ribosome-associated quality control	R-HSA-9948299	9.673267e-01	0.014
Signaling by Hedgehog	R-HSA-5358351	9.673267e-01	0.014
SARS-CoV-1-host interactions	R-HSA-9692914	9.674710e-01	0.014
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.685477e-01	0.014
Regulation of mitotic cell cycle	R-HSA-453276	9.685477e-01	0.014
Potential therapeutics for SARS	R-HSA-9679191	9.689491e-01	0.014
Activation of GABAB receptors	R-HSA-991365	9.695440e-01	0.013
GABA B receptor activation	R-HSA-977444	9.695440e-01	0.013
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	9.704677e-01	0.013
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.704677e-01	0.013
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.704677e-01	0.013
Cristae formation	R-HSA-8949613	9.704677e-01	0.013
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.704677e-01	0.013
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.704677e-01	0.013
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.704677e-01	0.013
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.704677e-01	0.013
Signaling by BMP	R-HSA-201451	9.704677e-01	0.013
Maturation of hRSV A proteins	R-HSA-9828806	9.704677e-01	0.013
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.721709e-01	0.012
Phase 0 - rapid depolarisation	R-HSA-5576892	9.734605e-01	0.012
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.734605e-01	0.012
Insulin receptor recycling	R-HSA-77387	9.734605e-01	0.012
Protein localization	R-HSA-9609507	9.735392e-01	0.012
Triglyceride metabolism	R-HSA-8979227	9.736350e-01	0.012
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.745783e-01	0.011
Gap junction trafficking	R-HSA-190828	9.745783e-01	0.011
Surfactant metabolism	R-HSA-5683826	9.745783e-01	0.011
Amine ligand-binding receptors	R-HSA-375280	9.745783e-01	0.011
MAPK family signaling cascades	R-HSA-5683057	9.749003e-01	0.011
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.750424e-01	0.011
Signaling by Erythropoietin	R-HSA-9006335	9.761501e-01	0.010
Transport to the Golgi and subsequent modification	R-HSA-948021	9.765395e-01	0.010
Iron uptake and transport	R-HSA-917937	9.766572e-01	0.010
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.767838e-01	0.010
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.767838e-01	0.010
Asymmetric localization of PCP proteins	R-HSA-4608870	9.767838e-01	0.010
Collagen degradation	R-HSA-1442490	9.775997e-01	0.010
Hedgehog 'off' state	R-HSA-5610787	9.777891e-01	0.010
DAP12 signaling	R-HSA-2424491	9.785673e-01	0.009
Neurotransmitter clearance	R-HSA-112311	9.785673e-01	0.009
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.785673e-01	0.009
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.793625e-01	0.009
Evasion by RSV of host interferon responses	R-HSA-9833109	9.807396e-01	0.008
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.807396e-01	0.008
G1/S DNA Damage Checkpoints	R-HSA-69615	9.809925e-01	0.008
PCP/CE pathway	R-HSA-4086400	9.814010e-01	0.008
SLC-mediated transport of organic anions	R-HSA-9955298	9.814010e-01	0.008
Cholesterol biosynthesis	R-HSA-191273	9.814010e-01	0.008
Beta-catenin independent WNT signaling	R-HSA-3858494	9.818951e-01	0.008
Metal ion SLC transporters	R-HSA-425410	9.823446e-01	0.008
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.824990e-01	0.008
Transmission across Chemical Synapses	R-HSA-112315	9.828448e-01	0.008
Neutrophil degranulation	R-HSA-6798695	9.838764e-01	0.007
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	9.838926e-01	0.007
p53-Dependent G1 DNA Damage Response	R-HSA-69563	9.838926e-01	0.007
Chemokine receptors bind chemokines	R-HSA-380108	9.838926e-01	0.007
Neuronal System	R-HSA-112316	9.839065e-01	0.007
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.844464e-01	0.007
Amyloid fiber formation	R-HSA-977225	9.852228e-01	0.006
SARS-CoV-1 Infection	R-HSA-9678108	9.852865e-01	0.006
Selenoamino acid metabolism	R-HSA-2408522	9.855837e-01	0.006
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.860231e-01	0.006
Acyl chain remodelling of PC	R-HSA-1482788	9.860231e-01	0.006
Effects of PIP2 hydrolysis	R-HSA-114508	9.860231e-01	0.006
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.860231e-01	0.006
Developmental Biology	R-HSA-1266738	9.860433e-01	0.006
Kidney development	R-HSA-9830369	9.863633e-01	0.006
Muscle contraction	R-HSA-397014	9.864568e-01	0.006
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.873426e-01	0.006
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.874401e-01	0.005
Gap junction assembly	R-HSA-190861	9.874401e-01	0.005
eNOS activation	R-HSA-203615	9.874401e-01	0.005
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.874401e-01	0.005
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.874585e-01	0.005
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.877855e-01	0.005
Platelet activation, signaling and aggregation	R-HSA-76002	9.881820e-01	0.005
Regulation of Apoptosis	R-HSA-169911	9.887135e-01	0.005
Acyl chain remodelling of PE	R-HSA-1482839	9.887135e-01	0.005
Amino acids regulate mTORC1	R-HSA-9639288	9.888664e-01	0.005
COPII-mediated vesicle transport	R-HSA-204005	9.894008e-01	0.005
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.899876e-01	0.004
Interferon gamma signaling	R-HSA-877300	9.907762e-01	0.004
Degradation of AXIN	R-HSA-4641257	9.908862e-01	0.004
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.908862e-01	0.004
Metabolism of folate and pterines	R-HSA-196757	9.908862e-01	0.004
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.918104e-01	0.004
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.923806e-01	0.003
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.926409e-01	0.003
RAS processing	R-HSA-9648002	9.926409e-01	0.003
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.926409e-01	0.003
Pentose phosphate pathway	R-HSA-71336	9.926409e-01	0.003
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.926409e-01	0.003
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.927187e-01	0.003
Neurotransmitter release cycle	R-HSA-112310	9.932622e-01	0.003
rRNA processing in the mitochondrion	R-HSA-8868766	9.933872e-01	0.003
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.933872e-01	0.003
Interferon alpha/beta signaling	R-HSA-909733	9.936303e-01	0.003
Hh mutants are degraded by ERAD	R-HSA-5362768	9.940579e-01	0.003
Toll-like Receptor Cascades	R-HSA-168898	9.940676e-01	0.003
Translation of Structural Proteins	R-HSA-9694635	9.941645e-01	0.003
GABA receptor activation	R-HSA-977443	9.942117e-01	0.003
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.942117e-01	0.003
Degradation of CRY and PER proteins	R-HSA-9932298	9.946606e-01	0.002
Scavenging by Class A Receptors	R-HSA-3000480	9.946606e-01	0.002
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.946606e-01	0.002
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.947035e-01	0.002
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.947035e-01	0.002
SARS-CoV Infections	R-HSA-9679506	9.950212e-01	0.002
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.952022e-01	0.002
Collagen formation	R-HSA-1474290	9.954941e-01	0.002
Neddylation	R-HSA-8951664	9.957199e-01	0.002
DAP12 interactions	R-HSA-2172127	9.961262e-01	0.002
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.961262e-01	0.002
Proteasome assembly	R-HSA-9907900	9.961262e-01	0.002
Regulation of pyruvate metabolism	R-HSA-9861718	9.968724e-01	0.001
RAF/MAP kinase cascade	R-HSA-5673001	9.969030e-01	0.001
Ion channel transport	R-HSA-983712	9.969439e-01	0.001
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.970622e-01	0.001
Signaling by Interleukins	R-HSA-449147	9.971128e-01	0.001
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.971897e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.974311e-01	0.001
Intraflagellar transport	R-HSA-5620924	9.974749e-01	0.001
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.975586e-01	0.001
SLC transporter disorders	R-HSA-5619102	9.976254e-01	0.001
Degradation of CDH1	R-HSA-9766229	9.977311e-01	0.001
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.977591e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.977591e-01	0.001
MAPK1/MAPK3 signaling	R-HSA-5684996	9.978636e-01	0.001
Regulation of RAS by GAPs	R-HSA-5658442	9.979614e-01	0.001
Azathioprine ADME	R-HSA-9748787	9.979614e-01	0.001
ECM proteoglycans	R-HSA-3000178	9.979636e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.979636e-01	0.001
Metabolism of porphyrins	R-HSA-189445	9.979636e-01	0.001
Translation	R-HSA-72766	9.980425e-01	0.001
ER-Phagosome pathway	R-HSA-1236974	9.981273e-01	0.001
Purine catabolism	R-HSA-74259	9.981497e-01	0.001
Complex IV assembly	R-HSA-9864848	9.981683e-01	0.001
Viral Infection Pathways	R-HSA-9824446	9.981872e-01	0.001
Cytokine Signaling in Immune system	R-HSA-1280215	9.982046e-01	0.001
Diseases of carbohydrate metabolism	R-HSA-5663084	9.983191e-01	0.001
RSV-host interactions	R-HSA-9833110	9.983227e-01	0.001
Uptake and actions of bacterial toxins	R-HSA-5339562	9.983542e-01	0.001
Signaling by ERBB4	R-HSA-1236394	9.984731e-01	0.001
Citric acid cycle (TCA cycle)	R-HSA-71403	9.986132e-01	0.001
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.986132e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.987498e-01	0.001
Paracetamol ADME	R-HSA-9753281	9.988062e-01	0.001
Phospholipid metabolism	R-HSA-1483257	9.988658e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.989033e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.989617e-01	0.000
TCR signaling	R-HSA-202403	9.989875e-01	0.000
Regulation of CDH1 Function	R-HSA-9764561	9.990363e-01	0.000
Synthesis of PA	R-HSA-1483166	9.990363e-01	0.000
Interleukin-1 family signaling	R-HSA-446652	9.990855e-01	0.000
FCERI mediated MAPK activation	R-HSA-2871796	9.991455e-01	0.000
Potassium Channels	R-HSA-1296071	9.991626e-01	0.000
Developmental Cell Lineages	R-HSA-9734767	9.992299e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.994198e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.994644e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.994644e-01	0.000
Interleukin-1 signaling	R-HSA-9020702	9.994674e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.994931e-01	0.000
Cardiac conduction	R-HSA-5576891	9.995067e-01	0.000
Adaptive Immune System	R-HSA-1280218	9.996388e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.996678e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.996697e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.996697e-01	0.000
Antigen processing-Cross presentation	R-HSA-1236975	9.997437e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.997605e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.997849e-01	0.000
Hedgehog 'on' state	R-HSA-5632684	9.997849e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.998008e-01	0.000
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.998067e-01	0.000
Aspirin ADME	R-HSA-9749641	9.998264e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.998440e-01	0.000
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.998666e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.998937e-01	0.000
ABC transporter disorders	R-HSA-5619084	9.998984e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999009e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.999087e-01	0.000
ABC-family proteins mediated transport	R-HSA-382556	9.999102e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999390e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.999519e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999625e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.999652e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999687e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999699e-01	0.000
Downstream TCR signaling	R-HSA-202424	9.999748e-01	0.000
Hemostasis	R-HSA-109582	9.999772e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.999813e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999851e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999864e-01	0.000
C-type lectin receptors (CLRs)	R-HSA-5621481	9.999873e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999877e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999948e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999949e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999963e-01	0.000
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.999963e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999967e-01	0.000
Platelet homeostasis	R-HSA-418346	9.999967e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999976e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999981e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999990e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999992e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999996e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999996e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999997e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999998e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999999e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999999e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999999e-01	0.000
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.999999e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
Infectious disease	R-HSA-5663205	9.999999e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999999e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999999e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	1.000000e+00	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Extracellular matrix organization	R-HSA-1474244	1.000000e+00	0.000
Immune System	R-HSA-168256	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000