HIPK3

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
O00115	S70	Sugiyama	DNASE2 DNASE2A DNL2	QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00165	S153	Sugiyama	HAX1 HS1BP1	PDSHQPRIFGGVLESDARSEsPQPAPDWGsQRPFHRFDDVW
O15047	S470	Sugiyama	SETD1A KIAA0339 KMT2F SET1 SET1A	sPEREEVRtsPRPAsPARsGsPAPEttNESVPFAQHSSLDS
O43488	S40	Sugiyama	AKR7A2 AFAR AFAR1 AKR7	SPPPEARALAMSRPPPPRVAsVLGTMEMGRRMDAPAsAAAV
O43765	T81	Sugiyama	SGTA SGT SGT1	IFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTEGNEQ
O60716	S252	Sugiyama	CTNND1 KIAA0384	sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O76080	S48	Sugiyama	ZFAND5 ZA20D2 ZNF216	GMCSVCYKEHLQRQQNsGRMsPMGtAsGsNsPtsDSASVQR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07437	S168	Sugiyama	TUBB TUBB5 OK/SW-cl.56	GTLLISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLS
P07437	S172	Sugiyama	TUBB TUBB5 OK/SW-cl.56	ISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLSVHQL
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P14618	S37	Sugiyama	PKM OIP3 PK2 PK3 PKM2	QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P17812	S575	Sugiyama	CTPS1 CTPS	LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27824	S362	Sugiyama	CANX	WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P29401	S295	Sugiyama	TKT	ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29401	T287	Sugiyama	TKT	AEQIIQEIysQIQsKKKILAtPPQEDAPsVDIANIRMPsLP
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P35269	T389	Sugiyama	GTF2F1 RAP74	PPKRERKPsGGSSRGNsRPGtPsAEGGstsstLRAAASKLE
P35611	S12	Sugiyama	ADD1 ADDA	_________MNGDsRAAVVtsPPPttAPHKERyFDRVDENN
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T87	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P42166	S158	Sugiyama	TMPO LAP2	tRKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsN
P42166	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsNDs
P42167	S158	Sugiyama	TMPO LAP2	TRKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSN
P42167	T160	Sugiyama	TMPO LAP2	KLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSNDS
P47712	S724	Sugiyama	PLA2G4A CPLA2 PLA2G4	NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P55036	S242	Sugiyama	PSMD4 MCB1	VSMEEQRQRQEEEARRAAAAsAAEAGIATTGtEDsDDALLK
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q13112	S410	Sugiyama	CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7	LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13158	S194	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	FADD MORT1 GIG3	ADLVQEVQQARDLQNRsGAMsPMsWNsDAsTSEAS______
Q13283	S231	Sugiyama	G3BP1 G3BP	QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13428	T1014	Sugiyama	TCOF1	ARssssEsEDEDVIPAtQCLtPGIRTNVVTMPTAHPRIAPK
Q13509	S168	Sugiyama	TUBB3 TUBB4	GTLLISKVREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLS
Q13509	S172	Sugiyama	TUBB3 TUBB4	ISKVREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLSIHQL
Q14157	S477	Sugiyama	UBAP2L KIAA0144 NICE4	PsKstsAPQMsPGssDNQsssPQPAQQKLKQQKKKAsLTSK
Q14160	S1448	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	QEDEQPPWAsPsPtsRQsPAsPPPLGGGAPVRTAKAERRHQ
Q14160	S1486	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	RHQERLRVQsPEPPAPERALsPAELRALEAEKRALWRAARM
Q14160	S1541	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	SRsQEGRGTRGPLERLAEAPsPAPtPsPtPVEDLGPQtsts
Q14160	T1545	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	EGRGTRGPLERLAEAPsPAPtPsPtPVEDLGPQtstsPGRL
Q14247	T401	Sugiyama	CTTN EMS1	RQEQEEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVy
Q14258	S100	Sugiyama	TRIM25 EFP RNF147 ZNF147	DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15637	S82	Sugiyama	SF1 ZFM1 ZNF162	TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q4KMP7	S28	Sugiyama	TBC1D10B FP2461	LVAPPRRHGAPAAPsPPPRGsRAGPVVVVAPGPPVTTATSA
Q53EL6	T93	Sugiyama	PDCD4 H731	RGDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLP
Q7Z2W4	T273	Sugiyama	ZC3HAV1 ZC3HDC2 PRO1677	FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q7Z460	S253	Sugiyama	CLASP1 KIAA0622 MAST1	IQSANDKNFDDEDsVDGNRPssAsStSSKAPPSSRRNVGMG
Q86UE4	S411	Sugiyama	MTDH AEG1 LYRIC	NSDWNAPAEEWGNWVDEERAsLLKsQEPIPDDQKVsDDDKE
Q86UE4	S415	Sugiyama	MTDH AEG1 LYRIC	NAPAEEWGNWVDEERAsLLKsQEPIPDDQKVsDDDKEKGEG
Q86YP4	S100	Sugiyama	GATAD2A	DGPVDMRTSHSDMKSERRPPsPDVIVLsDNEQPssPRVNGL
Q86Z02	S342	Sugiyama	HIPK1 KIAA0630 MYAK NBAK2	MLVDPVRQPYRVKVIDFGSAsHVSKAVCstyLQsRYYRAPE
Q8IWW6	S240	Sugiyama	ARHGAP12	SSSsTEQIRAttPPNQGRPDsPVyANLQELKISQSALPPLP
Q8IWW6	T231	Sugiyama	ARHGAP12	QDSEsGDELSSSsTEQIRAttPPNQGRPDsPVyANLQELKI
Q8IWX8	S815	Sugiyama	CHERP DAN26 SCAF6	RSQSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIP
Q8IWX8	S817	Sugiyama	CHERP DAN26 SCAF6	QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IZ21	S118	Sugiyama	PHACTR4 PRO2963	PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8N684	T203	Sugiyama	CPSF7	GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8WXI9	S122	Sugiyama	GATAD2B KIAA1150	DEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSsRM
Q8WXI9	T120	Sugiyama	GATAD2B KIAA1150	INDEPVDMSARRsEPERGRLtPsPDIIVLsDNEAssPRsSs
Q96MH2	S76	Sugiyama	HEXIM2 L3	EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q9C0C2	S1103	Sugiyama	TNKS1BP1 KIAA1741 TAB182	KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2	S504	Sugiyama	TNKS1BP1 KIAA1741 TAB182	PSGLGVWRLDsPPPsPItEAsEAAEAAEAGNLAVSSREEGV
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9H2X6	S351	Sugiyama	HIPK2	MLVDPSRQPYRVKVIDFGSAsHVSKAVCstyLQsRYyRAPE
Q9H422	S349	Sugiyama	HIPK3 DYRK6 FIST3 PKY	MLVDPVRQPYRVKVIDFGSAsHVSKTVCstyLQsRYYRAPE
Q9H422	S362	Sugiyama	HIPK3 DYRK6 FIST3 PKY	VIDFGSAsHVSKTVCstyLQsRYYRAPEIILGLPFCEAIDM
Q9H422	T177	Sugiyama	HIPK3 DYRK6 FIST3 PKY	NMGNPVTVVTATTGSKQNCTtGEGDYQLVQHEVLCSMKNTY
Q9H422	T250	Sugiyama	HIPK3 DYRK6 FIST3 PKY	NHPSYARQGQIEVSILARLStENADEYNFVRAYECFQHRNH
Q9H422	Y359	Sugiyama	HIPK3 DYRK6 FIST3 PKY	RVKVIDFGSAsHVSKTVCstyLQsRYYRAPEIILGLPFCEA
Q9HC35	S146	Sugiyama	EML4 C2orf2 EMAPL4	REKKEEsHsNDQsPQIRAsPsPQPssQPLQIHRQtPEsKNA
Q9NPI6	S523	Sugiyama	DCP1A SMIF	APSVFQQTVTRSSDLERKAssPsPLtIGtPEsQRKPSIILS
Q9NTJ3	T44	Sugiyama	SMC4 CAPC SMC4L1	DGAssDAEPEPPsGRtEsPAtAAEtAsEELDNRSLEEILNS
Q9UER7	S668	PSP	DAXX BING2 DAP6	YVERQRSVHEKNGKKICtLPsPPsPLAsLAPVADsstRVDs
Q9UHI6	T705	Sugiyama	DDX20 DP103 GEMIN3	sEstPVDDRIsLEQPPNGsDtPNPEKyQEsPGIQMKTRLKE
Q9UPQ0	S217	Sugiyama	LIMCH1 KIAA1102	GRDDsFDsLDsFGsRsRQtPsPDVVLRGssDGRGsDsEsDL
Q9UPQ0	T215	Sugiyama	LIMCH1 KIAA1102	RHGRDDsFDsLDsFGsRsRQtPsPDVVLRGssDGRGsDsEs
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9UQ35	S2398	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ANLtsPRVPLsAyERVsGRtsPPLLDRARsRtPPsAPsQsR

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Chromatin organization	R-HSA-4839726	3.894318e-11	10.410
Chromatin modifying enzymes	R-HSA-3247509	4.026494e-10	9.395
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	4.374144e-07	6.359
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.213512e-06	5.916
Cell Cycle	R-HSA-1640170	1.488580e-06	5.827
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.960261e-06	5.529
PKMTs methylate histone lysines	R-HSA-3214841	2.373365e-06	5.625
Cell Cycle, Mitotic	R-HSA-69278	3.105583e-06	5.508
Regulation of TP53 Activity	R-HSA-5633007	2.825152e-06	5.549
NRAGE signals death through JNK	R-HSA-193648	2.669377e-06	5.574
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.816390e-06	5.235
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.407180e-05	4.852
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.336774e-05	4.874
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.101781e-05	4.677
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.267703e-05	4.644
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.381587e-05	4.623
Gene expression (Transcription)	R-HSA-74160	4.272674e-05	4.369
Transport of the SLBP independent Mature mRNA	R-HSA-159227	5.803759e-05	4.236
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	7.578240e-05	4.120
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.033018e-04	3.986
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.033018e-04	3.986
Nuclear import of Rev protein	R-HSA-180746	1.049219e-04	3.979
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.389309e-04	3.857
G alpha (12/13) signalling events	R-HSA-416482	1.391137e-04	3.857
p75 NTR receptor-mediated signalling	R-HSA-193704	1.410095e-04	3.851
IPs transport between nucleus and cytosol	R-HSA-1855170	1.854985e-04	3.732
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.901925e-04	3.721
Circadian clock	R-HSA-9909396	2.117724e-04	3.674
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.408068e-04	3.618
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.368169e-04	3.626
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.446483e-04	3.611
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.166912e-04	3.499
HATs acetylate histones	R-HSA-3214847	3.017885e-04	3.520
Death Receptor Signaling	R-HSA-73887	3.098054e-04	3.509
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.051173e-04	3.516
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.898648e-04	3.409
RNA Polymerase II Transcription Termination	R-HSA-73856	4.482707e-04	3.348
Nuclear Envelope Breakdown	R-HSA-2980766	5.051637e-04	3.297
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.942104e-04	3.306
Interactions of Rev with host cellular proteins	R-HSA-177243	4.942104e-04	3.306
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.490913e-04	3.260
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	6.217390e-04	3.206
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	6.335648e-04	3.198
Apoptotic execution phase	R-HSA-75153	8.664977e-04	3.062
Mitotic Prophase	R-HSA-68875	9.714859e-04	3.013
mRNA 3'-end processing	R-HSA-72187	1.140620e-03	2.943
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.253488e-03	2.902
RUNX2 regulates bone development	R-HSA-8941326	1.455244e-03	2.837
RNA Polymerase II Transcription	R-HSA-73857	1.410698e-03	2.851
Transcriptional Regulation by TP53	R-HSA-3700989	1.509549e-03	2.821
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.588965e-03	2.799
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.747563e-03	2.758
HDMs demethylate histones	R-HSA-3214842	1.811039e-03	2.742
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.809522e-03	2.742
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.927662e-03	2.715
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.858175e-03	2.731
Polo-like kinase mediated events	R-HSA-156711	1.858175e-03	2.731
ISG15 antiviral mechanism	R-HSA-1169408	2.072098e-03	2.684
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.177215e-03	2.662
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.177215e-03	2.662
Repression of WNT target genes	R-HSA-4641265	2.225750e-03	2.653
Notch-HLH transcription pathway	R-HSA-350054	2.461805e-03	2.609
Regulation of TP53 Expression	R-HSA-6804754	2.647522e-03	2.577
Transcriptional regulation by small RNAs	R-HSA-5578749	2.791578e-03	2.554
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.227175e-03	2.491
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.204162e-03	2.494
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.227379e-03	2.491
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	3.369872e-03	2.472
Epigenetic regulation of gene expression	R-HSA-212165	3.645606e-03	2.438
G1/S-Specific Transcription	R-HSA-69205	3.763474e-03	2.424
Cell Cycle Checkpoints	R-HSA-69620	3.770107e-03	2.424
Adipogenesis	R-HSA-9843745	4.100295e-03	2.387
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.215260e-03	2.375
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.204657e-03	2.376
Specification of primordial germ cells	R-HSA-9827857	4.535127e-03	2.343
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.063724e-03	2.296
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.995266e-03	2.301
Viral Messenger RNA Synthesis	R-HSA-168325	5.114831e-03	2.291
SWI/SNF chromatin remodelers	R-HSA-9932451	5.202108e-03	2.284
ATP-dependent chromatin remodelers	R-HSA-9932444	5.202108e-03	2.284
TGFBR3 expression	R-HSA-9839394	5.202108e-03	2.284
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.647867e-03	2.248
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	5.896350e-03	2.229
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	5.896350e-03	2.229
G1/S Transition	R-HSA-69206	6.157689e-03	2.211
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.635822e-03	2.178
Transcriptional regulation by RUNX3	R-HSA-8878159	6.829720e-03	2.166
Cellular response to heat stress	R-HSA-3371556	6.509513e-03	2.186
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.188947e-03	2.143
G2/M Transition	R-HSA-69275	7.459516e-03	2.127
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.636363e-03	2.117
snRNP Assembly	R-HSA-191859	7.980327e-03	2.098
Metabolism of non-coding RNA	R-HSA-194441	7.980327e-03	2.098
Late Phase of HIV Life Cycle	R-HSA-162599	8.199490e-03	2.086
RUNX3 regulates NOTCH signaling	R-HSA-8941856	8.252613e-03	2.083
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	9.093791e-03	2.041
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	9.093791e-03	2.041
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	9.093791e-03	2.041
mRNA Splicing - Major Pathway	R-HSA-72163	8.790347e-03	2.056
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.593276e-03	2.066
Mitotic G2-G2/M phases	R-HSA-453274	8.702402e-03	2.060
Gastrulation	R-HSA-9758941	9.153704e-03	2.038
Generic Transcription Pathway	R-HSA-212436	9.425859e-03	2.026
Signaling by NOTCH1	R-HSA-1980143	9.515782e-03	2.022
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	9.828917e-03	2.007
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	9.961167e-03	2.002
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.075185e-02	1.969
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	1.105786e-02	1.956
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.075185e-02	1.969
G2/M Checkpoints	R-HSA-69481	1.253830e-02	1.902
mRNA Splicing	R-HSA-72172	1.267497e-02	1.897
M Phase	R-HSA-68886	1.381020e-02	1.860
G2/M DNA damage checkpoint	R-HSA-69473	1.419094e-02	1.848
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.435849e-02	1.843
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.435849e-02	1.843
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.483828e-02	1.829
RAF activation	R-HSA-5673000	1.497836e-02	1.825
Transcriptional regulation by RUNX1	R-HSA-8878171	1.649664e-02	1.783
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.564512e-02	1.806
HIV Life Cycle	R-HSA-162587	1.734217e-02	1.761
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.744271e-02	1.758
Cellular Senescence	R-HSA-2559583	1.771708e-02	1.752
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.790355e-02	1.747
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.790355e-02	1.747
Regulation of PTEN gene transcription	R-HSA-8943724	1.820270e-02	1.740
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.945658e-02	1.711
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.987605e-02	1.702
DNA Double-Strand Break Repair	R-HSA-5693532	1.998914e-02	1.699
Estrogen-dependent gene expression	R-HSA-9018519	1.941664e-02	1.712
Transcriptional Regulation by VENTX	R-HSA-8853884	2.052142e-02	1.688
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.060989e-02	1.686
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.067153e-02	1.685
G0 and Early G1	R-HSA-1538133	2.067301e-02	1.685
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.095530e-02	1.679
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	2.095530e-02	1.679
Germ layer formation at gastrulation	R-HSA-9754189	2.189941e-02	1.660
Specification of the neural plate border	R-HSA-9834899	2.189941e-02	1.660
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.211858e-02	1.655
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.415264e-02	1.617
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.435089e-02	1.613
Cardiogenesis	R-HSA-9733709	2.435089e-02	1.613
Activation of ATR in response to replication stress	R-HSA-176187	2.435089e-02	1.613
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.435089e-02	1.613
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.435089e-02	1.613
tRNA processing in the nucleus	R-HSA-6784531	2.316397e-02	1.635
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.461245e-02	1.609
Signal Transduction	R-HSA-162582	2.564686e-02	1.591
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.742070e-02	1.562
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.856475e-02	1.544
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.707135e-02	1.567
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	2.707135e-02	1.567
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.696893e-02	1.569
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.817998e-02	1.550
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.860220e-02	1.544
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	2.856475e-02	1.544
Glycolysis	R-HSA-70171	2.795468e-02	1.554
Transcriptional Regulation by MECP2	R-HSA-8986944	2.909102e-02	1.536
NGF-stimulated transcription	R-HSA-9031628	2.995513e-02	1.524
Processing of DNA double-strand break ends	R-HSA-5693607	3.001936e-02	1.523
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.061342e-02	1.514
Deubiquitination	R-HSA-5688426	3.067664e-02	1.513
MET interacts with TNS proteins	R-HSA-8875513	3.432811e-02	1.464
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.474786e-02	1.459
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.432953e-02	1.464
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.432953e-02	1.464
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.432953e-02	1.464
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.432953e-02	1.464
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.432953e-02	1.464
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.309471e-02	1.480
Formation of axial mesoderm	R-HSA-9796292	3.474786e-02	1.459
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.309471e-02	1.480
Inositol phosphate metabolism	R-HSA-1483249	3.152118e-02	1.501
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.281455e-02	1.484
Gene Silencing by RNA	R-HSA-211000	3.374859e-02	1.472
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.495627e-02	1.456
Homology Directed Repair	R-HSA-5693538	3.726711e-02	1.429
Signaling by Hippo	R-HSA-2028269	3.801168e-02	1.420
Apoptosis induced DNA fragmentation	R-HSA-140342	3.813956e-02	1.419
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.813956e-02	1.419
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.968541e-02	1.401
Transcriptional regulation by RUNX2	R-HSA-8878166	4.019210e-02	1.396
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.185569e-02	1.378
Heme signaling	R-HSA-9707616	4.254664e-02	1.371
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.254664e-02	1.371
Oncogenic MAPK signaling	R-HSA-6802957	4.362628e-02	1.360
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.370192e-02	1.359
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	4.370192e-02	1.359
Diseases of DNA repair	R-HSA-9675135	4.532894e-02	1.344
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.690728e-02	1.329
Formation of the posterior neural plate	R-HSA-9832991	4.946046e-02	1.306
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	5.335751e-02	1.273
S Phase	R-HSA-69242	4.910384e-02	1.309
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.219739e-02	1.282
Regulation of MECP2 expression and activity	R-HSA-9022692	5.219739e-02	1.282
Cyclin E associated events during G1/S transition	R-HSA-69202	5.356605e-02	1.271
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.362932e-02	1.271
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	5.362932e-02	1.271
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	5.362932e-02	1.271
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	5.362932e-02	1.271
Formation of the anterior neural plate	R-HSA-9823739	5.397699e-02	1.268
RUNX3 regulates WNT signaling	R-HSA-8951430	5.406067e-02	1.267
Apoptosis	R-HSA-109581	5.468937e-02	1.262
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.547488e-02	1.256
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.680108e-02	1.246
Signaling by TCF7L2 mutants	R-HSA-5339700	6.726569e-02	1.172
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	7.119597e-02	1.148
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	7.119597e-02	1.148
Type I hemidesmosome assembly	R-HSA-446107	7.119597e-02	1.148
MET receptor recycling	R-HSA-8875656	7.119597e-02	1.148
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	6.255508e-02	1.204
Signaling by AXIN mutants	R-HSA-4839735	6.255508e-02	1.204
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.580793e-02	1.182
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.580793e-02	1.182
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.580793e-02	1.182
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.580793e-02	1.182
Cyclin D associated events in G1	R-HSA-69231	6.765860e-02	1.170
G1 Phase	R-HSA-69236	6.765860e-02	1.170
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.559688e-02	1.183
FOXO-mediated transcription	R-HSA-9614085	6.669169e-02	1.176
Signaling by NOTCH	R-HSA-157118	7.019449e-02	1.154
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	7.119597e-02	1.148
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	6.779211e-02	1.169
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.559688e-02	1.183
Activation of the pre-replicative complex	R-HSA-68962	7.135098e-02	1.147
Mitotic Spindle Checkpoint	R-HSA-69618	7.174519e-02	1.144
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	7.205716e-02	1.142
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	7.205716e-02	1.142
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.205716e-02	1.142
Signaling by EGFR	R-HSA-177929	7.255683e-02	1.139
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.659214e-02	1.116
SMAC (DIABLO) binds to IAPs	R-HSA-111463	7.705737e-02	1.113
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	7.705737e-02	1.113
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	7.705737e-02	1.113
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	7.705737e-02	1.113
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.741565e-02	1.111
RUNX3 regulates p14-ARF	R-HSA-8951936	7.741565e-02	1.111
Processing of Intronless Pre-mRNAs	R-HSA-77595	7.856586e-02	1.105
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.722605e-02	1.112
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.969900e-02	1.047
HIV Transcription Initiation	R-HSA-167161	8.969900e-02	1.047
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.969900e-02	1.047
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	7.716353e-02	1.113
Amplification of signal from the kinetochores	R-HSA-141424	7.716353e-02	1.113
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.328681e-02	1.079
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.743926e-02	1.058
Negative regulation of MAPK pathway	R-HSA-5675221	8.969900e-02	1.047
RET signaling	R-HSA-8853659	8.606981e-02	1.065
TRAF3-dependent IRF activation pathway	R-HSA-918233	7.856586e-02	1.105
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	8.702722e-02	1.060
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	7.977506e-02	1.098
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.900926e-02	1.051
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.729014e-02	1.112
Signaling by TGFBR3	R-HSA-9839373	8.358368e-02	1.078
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	8.972722e-02	1.047
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	8.972722e-02	1.047
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	9.076161e-02	1.042
Diseases of mitotic cell cycle	R-HSA-9675126	9.177729e-02	1.037
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	9.177729e-02	1.037
Signaling by WNT in cancer	R-HSA-4791275	9.177729e-02	1.037
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.093400e-01	0.961
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.093400e-01	0.961
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.093400e-01	0.961
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.093400e-01	0.961
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.093400e-01	0.961
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.093400e-01	0.961
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.093400e-01	0.961
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.093400e-01	0.961
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.093400e-01	0.961
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.093400e-01	0.961
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.093400e-01	0.961
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	1.041674e-01	0.982
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.041674e-01	0.982
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.041674e-01	0.982
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	1.041674e-01	0.982
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	1.041674e-01	0.982
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	9.400160e-02	1.027
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	9.400160e-02	1.027
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.104234e-01	0.957
Formation of the Early Elongation Complex	R-HSA-113418	1.104234e-01	0.957
RNA Polymerase II Promoter Escape	R-HSA-73776	1.097483e-01	0.960
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.041152e-01	0.982
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	9.637345e-02	1.016
AURKA Activation by TPX2	R-HSA-8854518	1.045961e-01	0.980
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	9.555230e-02	1.020
Mitotic Prometaphase	R-HSA-68877	1.090623e-01	0.962
Activation of HOX genes during differentiation	R-HSA-5619507	1.008984e-01	0.996
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.008984e-01	0.996
Nuclear RNA decay	R-HSA-9930044	1.031521e-01	0.987
Ovarian tumor domain proteases	R-HSA-5689896	9.622649e-02	1.017
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.942351e-02	1.003
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.041152e-01	0.982
Signaling by TGFB family members	R-HSA-9006936	9.817969e-02	1.008
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.032976e-01	0.986
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	1.084745e-01	0.965
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	9.759101e-02	1.011
Kinesins	R-HSA-983189	1.041152e-01	0.982
Signaling by NTRKs	R-HSA-166520	1.014690e-01	0.994
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.031227e-01	0.987
Protein-protein interactions at synapses	R-HSA-6794362	1.117904e-01	0.952
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.122430e-01	0.950
Regulation of KIT signaling	R-HSA-1433559	1.122430e-01	0.950
HDACs deacetylate histones	R-HSA-3214815	1.125958e-01	0.948
Signaling by NOTCH3	R-HSA-9012852	1.125958e-01	0.948
Glucose metabolism	R-HSA-70326	1.179810e-01	0.928
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.185602e-01	0.926
Signaling by ALK	R-HSA-201556	1.185602e-01	0.926
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.208239e-01	0.918
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.216728e-01	0.915
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.222815e-01	0.913
Transcription of the HIV genome	R-HSA-167172	1.222815e-01	0.913
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.224987e-01	0.912
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.225850e-01	0.912
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.225850e-01	0.912
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.241277e-01	0.906
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.253326e-01	0.902
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.294991e-01	0.888
Defective Base Excision Repair Associated with NEIL1	R-HSA-9616334	1.309467e-01	0.883
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.309467e-01	0.883
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.309467e-01	0.883
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.309467e-01	0.883
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.309467e-01	0.883
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.309467e-01	0.883
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	1.563914e-01	0.806
Invadopodia formation	R-HSA-8941237	1.563914e-01	0.806
MET activates PTPN11	R-HSA-8865999	1.563914e-01	0.806
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.344337e-01	0.871
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	1.344337e-01	0.871
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.344337e-01	0.871
Signaling by APC mutants	R-HSA-4839744	1.365106e-01	0.865
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.365106e-01	0.865
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.365106e-01	0.865
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.365106e-01	0.865
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.622617e-01	0.790
Activation of RAC1	R-HSA-428540	1.622617e-01	0.790
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	1.622617e-01	0.790
Signaling by GSK3beta mutants	R-HSA-5339716	1.622617e-01	0.790
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.320443e-01	0.879
Differentiation of T cells	R-HSA-9945266	1.532890e-01	0.814
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	1.532890e-01	0.814
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.532890e-01	0.814
Negative regulation of MET activity	R-HSA-6807004	1.433798e-01	0.844
Sema4D in semaphorin signaling	R-HSA-400685	1.501218e-01	0.824
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.501218e-01	0.824
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.386771e-01	0.858
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	1.321714e-01	0.879
Signaling downstream of RAS mutants	R-HSA-9649948	1.442477e-01	0.841
mRNA Splicing - Minor Pathway	R-HSA-72165	1.442477e-01	0.841
PTEN Regulation	R-HSA-6807070	1.606899e-01	0.794
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.415983e-01	0.849
EGFR downregulation	R-HSA-182971	1.540382e-01	0.812
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.442477e-01	0.841
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.442477e-01	0.841
Signaling by RAS mutants	R-HSA-6802949	1.442477e-01	0.841
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.622617e-01	0.790
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.576135e-01	0.802
DNA Repair	R-HSA-73894	1.298896e-01	0.886
Activation of BH3-only proteins	R-HSA-114452	1.386771e-01	0.858
Programmed Cell Death	R-HSA-5357801	1.447609e-01	0.839
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	1.344337e-01	0.871
Signaling by AMER1 mutants	R-HSA-4839748	1.622617e-01	0.790
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.335354e-01	0.874
Neurodegenerative Diseases	R-HSA-8863678	1.335354e-01	0.874
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	1.320443e-01	0.879
FLT3 Signaling	R-HSA-9607240	1.435161e-01	0.843
MITF-M-dependent gene expression	R-HSA-9856651	1.540028e-01	0.812
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.625396e-01	0.789
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.447530e-01	0.611
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.447530e-01	0.611
Diseases of Telomere Maintenance	R-HSA-9673013	2.447530e-01	0.611
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.447530e-01	0.611
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-9036092	2.447530e-01	0.611
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.447530e-01	0.611
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.447530e-01	0.611
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.447530e-01	0.611
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.447530e-01	0.611
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	2.447530e-01	0.611
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.447530e-01	0.611
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.447530e-01	0.611
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	2.447530e-01	0.611
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.063961e-01	0.685
HCN channels	R-HSA-1296061	2.063961e-01	0.685
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.063961e-01	0.685
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.063961e-01	0.685
Defective LFNG causes SCDO3	R-HSA-5083630	2.063961e-01	0.685
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.063961e-01	0.685
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.063961e-01	0.685
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.436616e-01	0.464
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.436616e-01	0.464
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.436616e-01	0.464
XAV939 stabilizes AXIN	R-HSA-5545619	3.436616e-01	0.464
Defective VWF binding to collagen type I	R-HSA-9845622	3.436616e-01	0.464
Intestinal infectious diseases	R-HSA-8942233	3.436616e-01	0.464
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.436616e-01	0.464
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.436616e-01	0.464
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.436616e-01	0.464
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.436616e-01	0.464
PTEN Loss of Function in Cancer	R-HSA-5674404	3.436616e-01	0.464
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.436616e-01	0.464
Defective MMADHC causes MMAHCD	R-HSA-3359473	3.436616e-01	0.464
TRAF3 deficiency - HSE	R-HSA-5602571	3.436616e-01	0.464
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.436616e-01	0.464
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	1.672954e-01	0.777
Regulation of PTEN localization	R-HSA-8948747	1.672954e-01	0.777
NOSTRIN mediated eNOS trafficking	R-HSA-203641	1.672954e-01	0.777
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	1.672954e-01	0.777
Cohesin Loading onto Chromatin	R-HSA-2470946	1.672954e-01	0.777
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.672954e-01	0.777
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.577748e-01	0.589
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.577748e-01	0.589
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	2.021887e-01	0.694
Regulation of NPAS4 mRNA translation	R-HSA-9768778	2.021887e-01	0.694
Signaling by MRAS-complex mutants	R-HSA-9660537	2.021887e-01	0.694
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.021887e-01	0.694
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.896010e-01	0.722
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.896010e-01	0.722
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.896010e-01	0.722
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.896010e-01	0.722
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.896010e-01	0.722
GP1b-IX-V activation signalling	R-HSA-430116	2.385699e-01	0.622
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.385699e-01	0.622
ALK mutants bind TKIs	R-HSA-9700645	2.385699e-01	0.622
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.093109e-01	0.510
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.093109e-01	0.510
IkBA variant leads to EDA-ID	R-HSA-5603029	3.093109e-01	0.510
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.093109e-01	0.510
Regulation of cortical dendrite branching	R-HSA-8985801	4.296219e-01	0.367
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	4.296219e-01	0.367
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.296219e-01	0.367
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	4.296219e-01	0.367
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.296219e-01	0.367
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	4.296219e-01	0.367
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.182657e-01	0.661
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.182657e-01	0.661
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.182657e-01	0.661
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.759304e-01	0.559
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	2.759304e-01	0.559
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.827245e-01	0.738
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	2.479899e-01	0.606
Retrograde neurotrophin signalling	R-HSA-177504	2.479899e-01	0.606
Erythropoietin activates STAT5	R-HSA-9027283	3.600824e-01	0.444
G2/M DNA replication checkpoint	R-HSA-69478	3.600824e-01	0.444
Signaling by ERBB2 ECD mutants	R-HSA-9665348	2.242869e-01	0.649
Synaptic adhesion-like molecules	R-HSA-8849932	2.242869e-01	0.649
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	2.038384e-01	0.691
ChREBP activates metabolic gene expression	R-HSA-163765	3.138067e-01	0.503
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	3.138067e-01	0.503
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.138067e-01	0.503
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	3.138067e-01	0.503
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.859611e-01	0.731
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.859611e-01	0.731
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.785116e-01	0.555
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.785116e-01	0.555
Beta-catenin phosphorylation cascade	R-HSA-196299	2.785116e-01	0.555
E2F mediated regulation of DNA replication	R-HSA-113510	2.498604e-01	0.602
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	2.257781e-01	0.646
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	2.257781e-01	0.646
HIV elongation arrest and recovery	R-HSA-167287	2.050843e-01	0.688
Pausing and recovery of HIV elongation	R-HSA-167290	2.050843e-01	0.688
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.045648e-01	0.689
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.761195e-01	0.559
Co-inhibition by CTLA4	R-HSA-389513	2.761195e-01	0.559
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.517852e-01	0.454
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.517852e-01	0.454
MET activates PI3K/AKT signaling	R-HSA-8851907	4.094062e-01	0.388
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	4.094062e-01	0.388
PTK6 Expression	R-HSA-8849473	4.094062e-01	0.388
SOS-mediated signalling	R-HSA-112412	4.094062e-01	0.388
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	4.094062e-01	0.388
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	4.094062e-01	0.388
PLC-gamma1 signalling	R-HSA-167021	5.043283e-01	0.297
Activated NTRK3 signals through PLCG1	R-HSA-9034793	5.043283e-01	0.297
Defective MMACHC causes MAHCC	R-HSA-3359474	5.043283e-01	0.297
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	5.043283e-01	0.297
Activation of BIM and translocation to mitochondria	R-HSA-111446	5.043283e-01	0.297
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.043283e-01	0.297
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	5.043283e-01	0.297
Defective GCLC causes HAGGSD	R-HSA-5578999	5.043283e-01	0.297
Classical Kir channels	R-HSA-1296053	5.043283e-01	0.297
Defective GSS causes GSS deficiency	R-HSA-5579006	5.043283e-01	0.297
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.043283e-01	0.297
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.453723e-01	0.610
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.197427e-01	0.658
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.409500e-01	0.467
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.409500e-01	0.467
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	2.954615e-01	0.529
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.895043e-01	0.409
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	3.895043e-01	0.409
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.606602e-01	0.584
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.735199e-01	0.761
Condensation of Prophase Chromosomes	R-HSA-2299718	2.323923e-01	0.634
Signaling by RAF1 mutants	R-HSA-9656223	2.547971e-01	0.594
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.046768e-01	0.689
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.046768e-01	0.689
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.646834e-01	0.783
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.196056e-01	0.495
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.724045e-01	0.429
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	4.567908e-01	0.340
Centrosome maturation	R-HSA-380287	1.966503e-01	0.706
Regulation of endogenous retroelements	R-HSA-9842860	1.772846e-01	0.751
RNA Polymerase III Transcription Termination	R-HSA-73980	4.037373e-01	0.394
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	2.468604e-01	0.608
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.542346e-01	0.451
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	2.989454e-01	0.524
Formation of RNA Pol II elongation complex	R-HSA-112382	3.366249e-01	0.473
TRAF6 mediated NF-kB activation	R-HSA-933542	4.122317e-01	0.385
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	4.629744e-01	0.334
Removal of the Flap Intermediate	R-HSA-69166	4.629744e-01	0.334
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	5.018983e-01	0.299
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	5.018983e-01	0.299
Inactivation of CDC42 and RAC1	R-HSA-428543	5.018983e-01	0.299
Activated NTRK2 signals through PLCG1	R-HSA-9026527	5.692537e-01	0.245
TNFR1-mediated ceramide production	R-HSA-5626978	5.692537e-01	0.245
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	5.692537e-01	0.245
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.692537e-01	0.245
Signaling by MAP2K mutants	R-HSA-9652169	5.692537e-01	0.245
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.548711e-01	0.450
Nuclear Receptor transcription pathway	R-HSA-383280	3.255892e-01	0.487
Trafficking of AMPA receptors	R-HSA-399719	4.178708e-01	0.379
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	4.653207e-01	0.332
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	4.982518e-01	0.303
Erythropoietin activates RAS	R-HSA-9027284	4.982518e-01	0.303
Translesion synthesis by REV1	R-HSA-110312	4.982518e-01	0.303
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	4.982518e-01	0.303
Separation of Sister Chromatids	R-HSA-2467813	3.384164e-01	0.471
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.952640e-01	0.305
MET activates RAP1 and RAC1	R-HSA-8875555	5.445124e-01	0.264
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.445124e-01	0.264
DNA replication initiation	R-HSA-68952	5.445124e-01	0.264
HSF1-dependent transactivation	R-HSA-3371571	4.466074e-01	0.350
Translesion synthesis by POLI	R-HSA-5656121	5.323160e-01	0.274
Phosphorylation of the APC/C	R-HSA-176412	5.323160e-01	0.274
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.854320e-01	0.314
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	5.105265e-01	0.292
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	5.105265e-01	0.292
PPARA activates gene expression	R-HSA-1989781	4.688267e-01	0.329
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.943000e-01	0.306
MAP2K and MAPK activation	R-HSA-5674135	5.320048e-01	0.274
Signaling by Erythropoietin	R-HSA-9006335	5.441322e-01	0.264
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.441322e-01	0.264
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.441322e-01	0.264
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	5.650355e-01	0.248
Translesion synthesis by POLK	R-HSA-5655862	5.650355e-01	0.248
Presynaptic depolarization and calcium channel opening	R-HSA-112308	5.845124e-01	0.233
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.256781e-01	0.204
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	6.256781e-01	0.204
IRS activation	R-HSA-74713	6.256781e-01	0.204
NOSIP mediated eNOS trafficking	R-HSA-203754	6.256781e-01	0.204
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	6.256781e-01	0.204
FLT3 signaling by CBL mutants	R-HSA-9706377	6.256781e-01	0.204
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	6.256781e-01	0.204
PRC2 methylates histones and DNA	R-HSA-212300	5.601307e-01	0.252
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.688700e-01	0.245
Regulation of PTEN mRNA translation	R-HSA-8943723	5.802790e-01	0.236
Interleukin receptor SHC signaling	R-HSA-912526	5.802790e-01	0.236
RNA Polymerase I Promoter Escape	R-HSA-73772	6.044289e-01	0.219
MET promotes cell motility	R-HSA-8875878	6.038713e-01	0.219
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.067270e-01	0.217
Deadenylation of mRNA	R-HSA-429947	6.067270e-01	0.217
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	6.218520e-01	0.206
ERKs are inactivated	R-HSA-202670	6.218520e-01	0.206
Meiotic synapsis	R-HSA-1221632	6.226516e-01	0.206
Regulation of RUNX2 expression and activity	R-HSA-8939902	6.309223e-01	0.200
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	6.542311e-01	0.184
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.451311e-01	0.190
Pre-NOTCH Processing in Golgi	R-HSA-1912420	6.543080e-01	0.184
Translesion Synthesis by POLH	R-HSA-110320	6.543080e-01	0.184
Regulation of signaling by CBL	R-HSA-912631	6.543080e-01	0.184
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.543080e-01	0.184
MET activates RAS signaling	R-HSA-8851805	6.565417e-01	0.183
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.565417e-01	0.183
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.565417e-01	0.183
IRAK1 recruits IKK complex	R-HSA-937039	6.565417e-01	0.183
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.565417e-01	0.183
Polymerase switching	R-HSA-69091	6.565417e-01	0.183
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.565417e-01	0.183
Leading Strand Synthesis	R-HSA-69109	6.565417e-01	0.183
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	4.916445e-01	0.308
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.118527e-01	0.506
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.263660e-01	0.486
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.263660e-01	0.486
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.263660e-01	0.486
Nucleotide Excision Repair	R-HSA-5696398	4.758382e-01	0.323
HIV Transcription Elongation	R-HSA-167169	2.197427e-01	0.658
PIP3 activates AKT signaling	R-HSA-1257604	2.082337e-01	0.681
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	5.528377e-01	0.257
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.827245e-01	0.738
Formation of definitive endoderm	R-HSA-9823730	2.761195e-01	0.559
Signaling by MET	R-HSA-6806834	3.557501e-01	0.449
Adrenoceptors	R-HSA-390696	2.021887e-01	0.694
DNA Double Strand Break Response	R-HSA-5693606	1.763398e-01	0.754
mRNA Capping	R-HSA-72086	3.686079e-01	0.433
Mitotic Anaphase	R-HSA-68882	1.721865e-01	0.764
VxPx cargo-targeting to cilium	R-HSA-5620916	4.653207e-01	0.332
Regulation of CDH11 function	R-HSA-9762292	5.445124e-01	0.264
Switching of origins to a post-replicative state	R-HSA-69052	5.836413e-01	0.234
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.383958e-01	0.195
Neurexins and neuroligins	R-HSA-6794361	2.276353e-01	0.643
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.896010e-01	0.722
p75NTR recruits signalling complexes	R-HSA-209543	3.895043e-01	0.409
RNA Polymerase III Transcription	R-HSA-74158	2.606602e-01	0.584
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.786927e-01	0.748
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.197427e-01	0.658
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.362464e-01	0.473
Signaling by ERBB2	R-HSA-1227986	6.139228e-01	0.212
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.281274e-01	0.642
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	6.218520e-01	0.206
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	1.995611e-01	0.700
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	4.094062e-01	0.388
Myogenesis	R-HSA-525793	2.954615e-01	0.529
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.264199e-01	0.645
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.629744e-01	0.334
Processive synthesis on the lagging strand	R-HSA-69183	4.982518e-01	0.303
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.927697e-01	0.307
p75NTR signals via NF-kB	R-HSA-193639	2.785116e-01	0.555
DNA Replication Pre-Initiation	R-HSA-69002	3.430493e-01	0.465
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.385699e-01	0.622
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.242869e-01	0.649
Cytochrome c-mediated apoptotic response	R-HSA-111461	3.517852e-01	0.454
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.803197e-01	0.552
Regulation of the apoptosome activity	R-HSA-9627069	5.445124e-01	0.264
Transcriptional regulation of testis differentiation	R-HSA-9690406	5.650355e-01	0.248
Interleukin-15 signaling	R-HSA-8983432	6.565417e-01	0.183
Ephrin signaling	R-HSA-3928664	6.260842e-01	0.203
Meiosis	R-HSA-1500620	4.327133e-01	0.364
Hedgehog 'on' state	R-HSA-5632684	4.311881e-01	0.365
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.138067e-01	0.503
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.029589e-01	0.693
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	3.196056e-01	0.495
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.924859e-01	0.716
Lysosphingolipid and LPA receptors	R-HSA-419408	4.982518e-01	0.303
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.443228e-01	0.352
Formation of apoptosome	R-HSA-111458	5.445124e-01	0.264
DNA strand elongation	R-HSA-69190	6.161590e-01	0.210
Intracellular signaling by second messengers	R-HSA-9006925	2.486362e-01	0.604
Downregulation of ERBB2 signaling	R-HSA-8863795	5.688700e-01	0.245
Assembly of the pre-replicative complex	R-HSA-68867	5.834432e-01	0.234
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.218520e-01	0.206
Resolution of D-Loop Structures	R-HSA-5693537	2.045648e-01	0.689
RNA Polymerase III Transcription Initiation	R-HSA-76046	3.932563e-01	0.405
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.696718e-01	0.569
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.038713e-01	0.219
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	2.385699e-01	0.622
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.870300e-01	0.728
NF-kB is activated and signals survival	R-HSA-209560	3.517852e-01	0.454
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.197427e-01	0.658
Role of second messengers in netrin-1 signaling	R-HSA-418890	3.895043e-01	0.409
RNA Polymerase I Transcription Termination	R-HSA-73863	3.196056e-01	0.495
Regulation of gap junction activity	R-HSA-191650	5.692537e-01	0.245
Telomere C-strand synthesis initiation	R-HSA-174430	4.982518e-01	0.303
VLDLR internalisation and degradation	R-HSA-8866427	6.565417e-01	0.183
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.330971e-01	0.632
Clathrin-mediated endocytosis	R-HSA-8856828	3.330818e-01	0.477
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.224887e-01	0.206
UCH proteinases	R-HSA-5689603	2.960812e-01	0.529
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.372019e-01	0.472
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.386206e-01	0.195
Formation of paraxial mesoderm	R-HSA-9793380	2.675903e-01	0.573
Golgi-to-ER retrograde transport	R-HSA-8856688	5.973396e-01	0.224
Long-term potentiation	R-HSA-9620244	2.717011e-01	0.566
RNA Polymerase I Transcription	R-HSA-73864	2.338543e-01	0.631
Rap1 signalling	R-HSA-392517	4.347640e-01	0.362
Signal attenuation	R-HSA-74749	5.445124e-01	0.264
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.142388e-01	0.289
NoRC negatively regulates rRNA expression	R-HSA-427413	5.508162e-01	0.259
Apoptotic factor-mediated response	R-HSA-111471	6.260842e-01	0.203
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.565417e-01	0.183
TNF signaling	R-HSA-75893	1.948772e-01	0.710
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	2.954615e-01	0.529
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.960812e-01	0.529
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	5.445124e-01	0.264
Meiotic recombination	R-HSA-912446	5.857691e-01	0.232
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.924258e-01	0.534
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	4.178708e-01	0.379
Oncogene Induced Senescence	R-HSA-2559585	2.414395e-01	0.617
Somitogenesis	R-HSA-9824272	6.136954e-01	0.212
Semaphorin interactions	R-HSA-373755	2.989454e-01	0.524
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.919172e-01	0.535
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.577748e-01	0.589
Calcineurin activates NFAT	R-HSA-2025928	2.385699e-01	0.622
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.093109e-01	0.510
Diseases of Cellular Senescence	R-HSA-9630747	4.296219e-01	0.367
Diseases of cellular response to stress	R-HSA-9675132	4.296219e-01	0.367
Signaling by FGFR4 in disease	R-HSA-5655291	2.479899e-01	0.606
Activation of SMO	R-HSA-5635838	3.095781e-01	0.509
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	4.094062e-01	0.388
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.409500e-01	0.467
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.218606e-01	0.375
Regulation of necroptotic cell death	R-HSA-5675482	4.666349e-01	0.331
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.927697e-01	0.307
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	6.256781e-01	0.204
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	5.172466e-01	0.286
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.802790e-01	0.236
Organelle biogenesis and maintenance	R-HSA-1852241	6.192076e-01	0.208
TCF dependent signaling in response to WNT	R-HSA-201681	1.644827e-01	0.784
Signaling by Nuclear Receptors	R-HSA-9006931	4.503263e-01	0.346
Co-inhibition by PD-1	R-HSA-389948	5.777699e-01	0.238
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.484360e-01	0.605
RMTs methylate histone arginines	R-HSA-3214858	3.103543e-01	0.508
Regulation of TNFR1 signaling	R-HSA-5357905	2.323923e-01	0.634
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.402675e-01	0.194
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.105265e-01	0.292
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.895043e-01	0.409
HDR through Homologous Recombination (HRR)	R-HSA-5685942	2.603670e-01	0.584
Oxidative Stress Induced Senescence	R-HSA-2559580	2.454495e-01	0.610
MTOR signalling	R-HSA-165159	1.709509e-01	0.767
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	3.829344e-01	0.417
Signaling by SCF-KIT	R-HSA-1433557	5.737755e-01	0.241
MyD88-independent TLR4 cascade	R-HSA-166166	6.402675e-01	0.194
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.724045e-01	0.429
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.724045e-01	0.429
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.564493e-01	0.183
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	5.748655e-01	0.240
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.063961e-01	0.685
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.063961e-01	0.685
Release of Hh-Np from the secreting cell	R-HSA-5362798	3.093109e-01	0.510
Cell-extracellular matrix interactions	R-HSA-446353	2.785116e-01	0.555
Inhibition of nitric oxide production	R-HSA-9636249	5.043283e-01	0.297
CRMPs in Sema3A signaling	R-HSA-399956	4.629744e-01	0.334
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.692537e-01	0.245
Signaling by NOTCH4	R-HSA-9013694	4.813483e-01	0.318
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.963136e-01	0.225
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.770665e-01	0.557
MAP kinase activation	R-HSA-450294	3.773962e-01	0.423
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	4.906190e-01	0.309
Reproduction	R-HSA-1474165	3.174242e-01	0.498
Mismatch Repair	R-HSA-5358508	6.260842e-01	0.203
Signaling by NODAL	R-HSA-1181150	2.761195e-01	0.559
Mitochondrial biogenesis	R-HSA-1592230	3.833485e-01	0.416
Metabolism of RNA	R-HSA-8953854	1.653467e-01	0.782
Signaling by WNT	R-HSA-195721	6.179664e-01	0.209
ESR-mediated signaling	R-HSA-8939211	3.952599e-01	0.403
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.644055e-01	0.333
Cell junction organization	R-HSA-446728	2.290932e-01	0.640
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	2.577748e-01	0.589
Neurofascin interactions	R-HSA-447043	3.600824e-01	0.444
TBC/RABGAPs	R-HSA-8854214	1.855364e-01	0.732
ERK/MAPK targets	R-HSA-198753	3.029031e-01	0.519
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.916601e-01	0.535
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.620513e-01	0.441
Vasopressin-like receptors	R-HSA-388479	5.692537e-01	0.245
Interleukin-17 signaling	R-HSA-448424	4.143943e-01	0.383
Recycling pathway of L1	R-HSA-437239	5.073628e-01	0.295
Regulation of T cell activation by CD28 family	R-HSA-388841	6.328449e-01	0.199
Signaling by EGFR in Cancer	R-HSA-1643713	6.564493e-01	0.183
Membrane Trafficking	R-HSA-199991	6.343510e-01	0.198
Nervous system development	R-HSA-9675108	3.694151e-01	0.432
Diseases of programmed cell death	R-HSA-9645723	2.926106e-01	0.534
Regulation of TP53 Degradation	R-HSA-6804757	3.993102e-01	0.399
Axon guidance	R-HSA-422475	4.003597e-01	0.398
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.952640e-01	0.305
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.952640e-01	0.305
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.063409e-01	0.685
Adherens junctions interactions	R-HSA-418990	3.482844e-01	0.458
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.649622e-01	0.248
mRNA Editing	R-HSA-75072	5.018983e-01	0.299
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	5.963136e-01	0.225
Cell-cell junction organization	R-HSA-421270	4.592067e-01	0.338
Ub-specific processing proteases	R-HSA-5689880	2.402641e-01	0.619
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.649622e-01	0.248
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.649622e-01	0.248
Cellular responses to stress	R-HSA-2262752	5.401134e-01	0.268
Signaling by VEGF	R-HSA-194138	4.095786e-01	0.388
Regulation of CDH1 Expression and Function	R-HSA-9764265	5.219362e-01	0.282
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	5.219362e-01	0.282
Rab regulation of trafficking	R-HSA-9007101	4.739244e-01	0.324
Signaling by BMP	R-HSA-201451	4.927697e-01	0.307
Cell-Cell communication	R-HSA-1500931	4.128317e-01	0.384
Formation of editosomes by ADAR proteins	R-HSA-77042	2.447530e-01	0.611
NrCAM interactions	R-HSA-447038	2.577748e-01	0.589
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.577748e-01	0.589
Sensory perception of salty taste	R-HSA-9730628	3.093109e-01	0.510
mRNA Editing: A to I Conversion	R-HSA-75064	4.296219e-01	0.367
C6 deamination of adenosine	R-HSA-75102	4.296219e-01	0.367
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.827245e-01	0.738
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.045648e-01	0.689
MET activates STAT3	R-HSA-8875791	5.043283e-01	0.297
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.567908e-01	0.340
Unwinding of DNA	R-HSA-176974	5.018983e-01	0.299
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.692537e-01	0.245
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	5.692537e-01	0.245
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.692537e-01	0.245
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.256781e-01	0.204
Evasion by RSV of host interferon responses	R-HSA-9833109	5.928955e-01	0.227
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.260842e-01	0.203
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.543080e-01	0.184
Signaling by PTK6	R-HSA-8848021	2.046768e-01	0.689
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.046768e-01	0.689
Post NMDA receptor activation events	R-HSA-438064	5.883224e-01	0.230
Signaling by FGFR1 in disease	R-HSA-5655302	5.320048e-01	0.274
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	5.474693e-01	0.262
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	6.198781e-01	0.208
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.759304e-01	0.559
Pexophagy	R-HSA-9664873	5.445124e-01	0.264
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	6.321296e-01	0.199
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.206537e-01	0.494
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.855364e-01	0.732
PI Metabolism	R-HSA-1483255	3.271922e-01	0.485
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.666349e-01	0.331
PECAM1 interactions	R-HSA-210990	3.138067e-01	0.503
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.920062e-01	0.717
MDK and PTN in ALK signaling	R-HSA-9851151	5.692537e-01	0.245
TRP channels	R-HSA-3295583	4.662969e-01	0.331
DCC mediated attractive signaling	R-HSA-418885	2.785116e-01	0.555
Negative regulation of FLT3	R-HSA-9706369	5.323160e-01	0.274
HIV Infection	R-HSA-162906	2.507451e-01	0.601
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	2.021887e-01	0.694
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.093109e-01	0.510
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.567908e-01	0.340
Regulated proteolysis of p75NTR	R-HSA-193692	5.018983e-01	0.299
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.692537e-01	0.245
Signaling by Activin	R-HSA-1502540	4.982518e-01	0.303
Formation of intermediate mesoderm	R-HSA-9761174	5.445124e-01	0.264
Displacement of DNA glycosylase by APEX1	R-HSA-110357	1.672954e-01	0.777
mTORC1-mediated signalling	R-HSA-166208	5.528377e-01	0.257
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.391464e-01	0.621
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.037373e-01	0.394
Zygotic genome activation (ZGA)	R-HSA-9819196	3.029031e-01	0.519
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	5.802790e-01	0.236
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.294600e-01	0.482
SARS-CoV-2-host interactions	R-HSA-9705683	5.098151e-01	0.293
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	5.531025e-01	0.257
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.052420e-01	0.515
Signaling by ALK in cancer	R-HSA-9700206	2.391464e-01	0.621
Breakdown of the nuclear lamina	R-HSA-352238	3.436616e-01	0.464
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	3.095781e-01	0.509
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.043283e-01	0.297
CASP5-mediated substrate cleavage	R-HSA-9960525	5.043283e-01	0.297
Signaling by PDGFR in disease	R-HSA-9671555	3.300538e-01	0.481
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.097076e-01	0.509
Transcriptional Regulation by E2F6	R-HSA-8953750	3.206968e-01	0.494
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.037373e-01	0.394
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	4.629744e-01	0.334
Sensory perception of sour taste	R-HSA-9729555	5.692537e-01	0.245
NADE modulates death signalling	R-HSA-205025	5.692537e-01	0.245
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.952640e-01	0.305
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.445124e-01	0.264
Disorders of Developmental Biology	R-HSA-9675151	5.650355e-01	0.248
Synthesis of PI	R-HSA-1483226	5.845124e-01	0.233
PTK6 Down-Regulation	R-HSA-8849472	6.256781e-01	0.204
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	6.044289e-01	0.219
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.067270e-01	0.217
Netrin-1 signaling	R-HSA-373752	2.006611e-01	0.698
Nuclear signaling by ERBB4	R-HSA-1251985	4.887167e-01	0.311
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.686079e-01	0.433
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.829344e-01	0.417
MITF-M-regulated melanocyte development	R-HSA-9730414	1.965251e-01	0.707
Regulation of CDH11 gene transcription	R-HSA-9762293	2.385699e-01	0.622
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.785116e-01	0.555
Interleukin-37 signaling	R-HSA-9008059	2.453723e-01	0.610
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.097076e-01	0.509
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.999252e-01	0.301
Tie2 Signaling	R-HSA-210993	6.260842e-01	0.203
Host Interactions of HIV factors	R-HSA-162909	3.846967e-01	0.415
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	4.296219e-01	0.367
MECP2 regulates transcription factors	R-HSA-9022707	4.094062e-01	0.388
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	5.043283e-01	0.297
CASP4-mediated substrate cleavage	R-HSA-9960519	5.043283e-01	0.297
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.692537e-01	0.245
Dopamine receptors	R-HSA-390651	5.692537e-01	0.245
Anchoring fibril formation	R-HSA-2214320	6.218520e-01	0.206
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	6.564493e-01	0.183
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.954615e-01	0.529
Influenza Infection	R-HSA-168255	3.615678e-01	0.442
STING mediated induction of host immune responses	R-HSA-1834941	6.543080e-01	0.184
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.577748e-01	0.589
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	4.296219e-01	0.367
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.029031e-01	0.519
Interleukin-1 processing	R-HSA-448706	5.018983e-01	0.299
Uptake and function of anthrax toxins	R-HSA-5210891	5.963136e-01	0.225
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.218520e-01	0.206
Signaling by LTK	R-HSA-9842663	6.565417e-01	0.183
Pervasive developmental disorders	R-HSA-9005895	6.565417e-01	0.183
Disorders of Nervous System Development	R-HSA-9697154	6.565417e-01	0.183
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.565417e-01	0.183
Regulation of NPAS4 gene expression	R-HSA-9768759	5.963136e-01	0.225
tRNA processing	R-HSA-72306	6.437021e-01	0.191
Interleukin-7 signaling	R-HSA-1266695	6.321296e-01	0.199
Nectin/Necl trans heterodimerization	R-HSA-420597	6.256781e-01	0.204
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.422551e-01	0.266
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.602490e-01	0.180
RAF/MAP kinase cascade	R-HSA-5673001	6.625950e-01	0.179
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.647559e-01	0.177
Nonsense-Mediated Decay (NMD)	R-HSA-927802	6.649627e-01	0.177
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	6.649627e-01	0.177
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.667155e-01	0.176
Co-stimulation by CD28	R-HSA-389356	6.695633e-01	0.174
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	6.695633e-01	0.174
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.744757e-01	0.171
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.747142e-01	0.171
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.747142e-01	0.171
Signalling to p38 via RIT and RIN	R-HSA-187706	6.747142e-01	0.171
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.747142e-01	0.171
Phosphorylation of Emi1	R-HSA-176417	6.747142e-01	0.171
PKB-mediated events	R-HSA-109703	6.747142e-01	0.171
Noncanonical activation of NOTCH3	R-HSA-9017802	6.747142e-01	0.171
PDE3B signalling	R-HSA-165160	6.747142e-01	0.171
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.747142e-01	0.171
Signaling by RNF43 mutants	R-HSA-5340588	6.747142e-01	0.171
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.747142e-01	0.171
Ligand-receptor interactions	R-HSA-5632681	6.747142e-01	0.171
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.747142e-01	0.171
Pentose phosphate pathway disease	R-HSA-6791465	6.747142e-01	0.171
Synthesis of PS	R-HSA-1483101	6.747142e-01	0.171
CDC6 association with the ORC:origin complex	R-HSA-68689	6.747142e-01	0.171
Formation of the Editosome	R-HSA-75094	6.747142e-01	0.171
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.747142e-01	0.171
Diseases of Base Excision Repair	R-HSA-9605308	6.747142e-01	0.171
CLEC7A/inflammasome pathway	R-HSA-5660668	6.747142e-01	0.171
Relaxin receptors	R-HSA-444821	6.747142e-01	0.171
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.747142e-01	0.171
Sensory processing of sound	R-HSA-9659379	6.750150e-01	0.171
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.769604e-01	0.169
EPHA-mediated growth cone collapse	R-HSA-3928663	6.796616e-01	0.168
Interaction between L1 and Ankyrins	R-HSA-445095	6.796616e-01	0.168
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.796616e-01	0.168
Signaling by FGFR3 in disease	R-HSA-5655332	6.796616e-01	0.168
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.796616e-01	0.168
Regulation of PD-L1(CD274) translation	R-HSA-9909620	6.809681e-01	0.167
Protein hydroxylation	R-HSA-9629569	6.809681e-01	0.167
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.810219e-01	0.167
Signaling by NOTCH2	R-HSA-1980145	6.810219e-01	0.167
SARS-CoV-1-host interactions	R-HSA-9692914	6.835288e-01	0.165
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	6.842598e-01	0.165
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.870285e-01	0.163
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.870285e-01	0.163
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	6.886351e-01	0.162
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	6.886351e-01	0.162
Platelet Adhesion to exposed collagen	R-HSA-75892	6.886351e-01	0.162
Frs2-mediated activation	R-HSA-170968	6.886351e-01	0.162
Membrane binding and targetting of GAG proteins	R-HSA-174490	6.886351e-01	0.162
PI5P Regulates TP53 Acetylation	R-HSA-6811555	6.886351e-01	0.162
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	6.886351e-01	0.162
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.890479e-01	0.162
Cellular response to hypoxia	R-HSA-1234174	6.946584e-01	0.158
Ca2+ pathway	R-HSA-4086398	6.986674e-01	0.156
Signalling to ERKs	R-HSA-187687	7.009241e-01	0.154
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	7.009241e-01	0.154
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.018977e-01	0.154
Signaling by FGFR2 in disease	R-HSA-5655253	7.038908e-01	0.152
Lagging Strand Synthesis	R-HSA-69186	7.060671e-01	0.151
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.060671e-01	0.151
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.071978e-01	0.150
Interferon Signaling	R-HSA-913531	7.089399e-01	0.149
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.107547e-01	0.148
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.114734e-01	0.148
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.122007e-01	0.147
Signaling by FGFR in disease	R-HSA-1226099	7.126588e-01	0.147
MAPK1/MAPK3 signaling	R-HSA-5684996	7.148650e-01	0.146
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	7.159938e-01	0.145
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	7.173291e-01	0.144
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.173291e-01	0.144
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	7.173291e-01	0.144
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	7.173291e-01	0.144
MET Receptor Activation	R-HSA-6806942	7.173291e-01	0.144
PTK6 promotes HIF1A stabilization	R-HSA-8857538	7.173291e-01	0.144
CREB phosphorylation	R-HSA-199920	7.173291e-01	0.144
NADPH regeneration	R-HSA-389542	7.173291e-01	0.144
CREB3 factors activate genes	R-HSA-8874211	7.173291e-01	0.144
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	7.182169e-01	0.144
Physiological factors	R-HSA-5578768	7.182169e-01	0.144
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.186224e-01	0.143
Signaling by FGFR4	R-HSA-5654743	7.193914e-01	0.143
Defective pyroptosis	R-HSA-9710421	7.193914e-01	0.143
Calmodulin induced events	R-HSA-111933	7.199477e-01	0.143
CaM pathway	R-HSA-111997	7.199477e-01	0.143
FLT3 signaling in disease	R-HSA-9682385	7.199477e-01	0.143
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.201412e-01	0.143
Deadenylation-dependent mRNA decay	R-HSA-429914	7.217042e-01	0.142
DNA methylation	R-HSA-5334118	7.227241e-01	0.141
Downstream signaling of activated FGFR3	R-HSA-5654708	7.227241e-01	0.141
HCMV Late Events	R-HSA-9610379	7.258865e-01	0.139
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.296235e-01	0.137
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.296235e-01	0.137
Potential therapeutics for SARS	R-HSA-9679191	7.313857e-01	0.136
L1CAM interactions	R-HSA-373760	7.331964e-01	0.135
EPHB-mediated forward signaling	R-HSA-3928662	7.361595e-01	0.133
Regulated Necrosis	R-HSA-5218859	7.376483e-01	0.132
Degradation of AXIN	R-HSA-4641257	7.380913e-01	0.132
TRAF6 mediated IRF7 activation	R-HSA-933541	7.380913e-01	0.132
Signaling by ROBO receptors	R-HSA-376176	7.399250e-01	0.131
Downstream signaling of activated FGFR4	R-HSA-5654716	7.425786e-01	0.129
DAP12 signaling	R-HSA-2424491	7.425786e-01	0.129
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.432702e-01	0.129
Cellular responses to stimuli	R-HSA-8953897	7.436010e-01	0.129
Activation of BAD and translocation to mitochondria	R-HSA-111447	7.453943e-01	0.128
RNA Polymerase III Chain Elongation	R-HSA-73780	7.453943e-01	0.128
Spry regulation of FGF signaling	R-HSA-1295596	7.453943e-01	0.128
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	7.453943e-01	0.128
IRF3-mediated induction of type I IFN	R-HSA-3270619	7.453943e-01	0.128
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.507883e-01	0.124
FGFR2 alternative splicing	R-HSA-6803529	7.516690e-01	0.124
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.516690e-01	0.124
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.516690e-01	0.124
RAF-independent MAPK1/3 activation	R-HSA-112409	7.516690e-01	0.124
Signaling by FGFR3	R-HSA-5654741	7.522016e-01	0.124
DAG and IP3 signaling	R-HSA-1489509	7.522016e-01	0.124
Signaling by Hedgehog	R-HSA-5358351	7.527172e-01	0.123
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	7.543632e-01	0.122
Glycoprotein hormones	R-HSA-209822	7.543632e-01	0.122
TRIF-mediated programmed cell death	R-HSA-2562578	7.543632e-01	0.122
IFNG signaling activates MAPKs	R-HSA-9732724	7.543632e-01	0.122
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	7.543632e-01	0.122
Recycling of eIF2:GDP	R-HSA-72731	7.543632e-01	0.122
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	7.543632e-01	0.122
mRNA Editing: C to U Conversion	R-HSA-72200	7.543632e-01	0.122
Nef Mediated CD4 Down-regulation	R-HSA-167590	7.543632e-01	0.122
VLDL clearance	R-HSA-8964046	7.543632e-01	0.122
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.543632e-01	0.122
Cation-coupled Chloride cotransporters	R-HSA-426117	7.543632e-01	0.122
CHL1 interactions	R-HSA-447041	7.543632e-01	0.122
Maturation of replicase proteins	R-HSA-9694301	7.543632e-01	0.122
MAPK family signaling cascades	R-HSA-5683057	7.563292e-01	0.121
Cilium Assembly	R-HSA-5617833	7.572333e-01	0.121
DNA Replication	R-HSA-69306	7.586471e-01	0.120
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	7.637818e-01	0.117
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	7.637818e-01	0.117
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.651836e-01	0.116
EPH-Ephrin signaling	R-HSA-2682334	7.664883e-01	0.115
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	7.675212e-01	0.115
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.675212e-01	0.115
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.702895e-01	0.113
Defective GALNT3 causes HFTC	R-HSA-5083625	7.702895e-01	0.113
Defective GALNT12 causes CRCS1	R-HSA-5083636	7.702895e-01	0.113
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	7.702895e-01	0.113
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	7.702895e-01	0.113
Prolonged ERK activation events	R-HSA-169893	7.702895e-01	0.113
Growth hormone receptor signaling	R-HSA-982772	7.722458e-01	0.112
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	7.756215e-01	0.110
G1/S DNA Damage Checkpoints	R-HSA-69615	7.771701e-01	0.109
Hedgehog 'off' state	R-HSA-5610787	7.784288e-01	0.109
Synthesis of DNA	R-HSA-69239	7.797271e-01	0.108
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.821251e-01	0.107
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.828178e-01	0.106
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	7.865471e-01	0.104
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.865471e-01	0.104
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.865471e-01	0.104
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.865471e-01	0.104
Regulation by c-FLIP	R-HSA-3371378	7.865471e-01	0.104
Formation of annular gap junctions	R-HSA-196025	7.865471e-01	0.104
TGFBR3 PTM regulation	R-HSA-9839383	7.865471e-01	0.104
Dimerization of procaspase-8	R-HSA-69416	7.865471e-01	0.104
Sodium/Proton exchangers	R-HSA-425986	7.865471e-01	0.104
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.873053e-01	0.104
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.873053e-01	0.104
PKR-mediated signaling	R-HSA-9833482	7.876210e-01	0.104
Ion transport by P-type ATPases	R-HSA-936837	7.896915e-01	0.103
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.914042e-01	0.102
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	7.919278e-01	0.101
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	7.919278e-01	0.101
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.930338e-01	0.101
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	7.930338e-01	0.101
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	7.930338e-01	0.101
Glycine degradation	R-HSA-6783984	7.930338e-01	0.101
Fibronectin matrix formation	R-HSA-1566977	7.930338e-01	0.101
tRNA modification in the mitochondrion	R-HSA-6787450	7.930338e-01	0.101
Synthesis of PG	R-HSA-1483148	7.930338e-01	0.101
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.020150e-01	0.096
HCMV Early Events	R-HSA-9609690	8.021583e-01	0.096
KEAP1-NFE2L2 pathway	R-HSA-9755511	8.060489e-01	0.094
Laminin interactions	R-HSA-3000157	8.092010e-01	0.092
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.092010e-01	0.092
Tight junction interactions	R-HSA-420029	8.092010e-01	0.092
Acyl chain remodelling of PS	R-HSA-1482801	8.092010e-01	0.092
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.092010e-01	0.092
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.092010e-01	0.092
Developmental Biology	R-HSA-1266738	8.100832e-01	0.091
Signaling by ERBB4	R-HSA-1236394	8.107420e-01	0.091
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.136765e-01	0.090
PI3K events in ERBB2 signaling	R-HSA-1963642	8.137635e-01	0.090
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.137635e-01	0.090
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.137635e-01	0.090
Regulation of FZD by ubiquitination	R-HSA-4641263	8.137635e-01	0.090
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	8.137635e-01	0.090
CASP8 activity is inhibited	R-HSA-5218900	8.145159e-01	0.089
Gap junction degradation	R-HSA-190873	8.145159e-01	0.089
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	8.145159e-01	0.089
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	8.145159e-01	0.089
Regulation of signaling by NODAL	R-HSA-1433617	8.145159e-01	0.089
MASTL Facilitates Mitotic Progression	R-HSA-2465910	8.145159e-01	0.089
Lipophagy	R-HSA-9613354	8.145159e-01	0.089
Cellular response to mitochondrial stress	R-HSA-9840373	8.145159e-01	0.089
Butyrophilin (BTN) family interactions	R-HSA-8851680	8.145159e-01	0.089
Degradation of CRY and PER proteins	R-HSA-9932298	8.159082e-01	0.088
Dual incision in TC-NER	R-HSA-6782135	8.166837e-01	0.088
Response of endothelial cells to shear stress	R-HSA-9860931	8.169118e-01	0.088
Cytoprotection by HMOX1	R-HSA-9707564	8.193172e-01	0.087
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.212773e-01	0.086
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.256971e-01	0.083
MET activates PTK2 signaling	R-HSA-8874081	8.256971e-01	0.083
Metalloprotease DUBs	R-HSA-5689901	8.256971e-01	0.083
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.256971e-01	0.083
RSV-host interactions	R-HSA-9833110	8.257144e-01	0.083
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.258319e-01	0.083
NOD1/2 Signaling Pathway	R-HSA-168638	8.258319e-01	0.083
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.280833e-01	0.082
Regulation of beta-cell development	R-HSA-186712	8.280833e-01	0.082
Depyrimidination	R-HSA-73928	8.290078e-01	0.081
Cleavage of the damaged pyrimidine	R-HSA-110329	8.290078e-01	0.081
Ca-dependent events	R-HSA-111996	8.290078e-01	0.081
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.326159e-01	0.080
Chaperone Mediated Autophagy	R-HSA-9613829	8.326159e-01	0.080
PKA activation in glucagon signalling	R-HSA-164378	8.326159e-01	0.080
Platelet sensitization by LDL	R-HSA-432142	8.326159e-01	0.080
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	8.326159e-01	0.080
IRE1alpha activates chaperones	R-HSA-381070	8.364568e-01	0.078
MAPK3 (ERK1) activation	R-HSA-110056	8.388213e-01	0.076
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	8.388213e-01	0.076
Peptide hormone biosynthesis	R-HSA-209952	8.388213e-01	0.076
PI3K/AKT activation	R-HSA-198203	8.388213e-01	0.076
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	8.388213e-01	0.076
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.388213e-01	0.076
EGFR Transactivation by Gastrin	R-HSA-2179392	8.388213e-01	0.076
Receptor Mediated Mitophagy	R-HSA-8934903	8.388213e-01	0.076
Signaling by Leptin	R-HSA-2586552	8.388213e-01	0.076
Downstream signaling of activated FGFR2	R-HSA-5654696	8.394909e-01	0.076
Downstream signaling of activated FGFR1	R-HSA-5654687	8.394909e-01	0.076
RNA Polymerase I Promoter Opening	R-HSA-73728	8.409567e-01	0.075
Maturation of hRSV A proteins	R-HSA-9828806	8.409567e-01	0.075
Cellular responses to mechanical stimuli	R-HSA-9855142	8.415941e-01	0.075
Orc1 removal from chromatin	R-HSA-68949	8.448416e-01	0.073
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	8.448416e-01	0.073
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.448416e-01	0.073
Collagen degradation	R-HSA-1442490	8.491986e-01	0.071
PI-3K cascade:FGFR3	R-HSA-5654710	8.497269e-01	0.071
Crosslinking of collagen fibrils	R-HSA-2243919	8.497269e-01	0.071
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.497269e-01	0.071
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.497269e-01	0.071
Other interleukin signaling	R-HSA-449836	8.497269e-01	0.071
The NLRP3 inflammasome	R-HSA-844456	8.497269e-01	0.071
GPVI-mediated activation cascade	R-HSA-114604	8.522390e-01	0.069
Triglyceride catabolism	R-HSA-163560	8.522390e-01	0.069
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.529282e-01	0.069
COPII-mediated vesicle transport	R-HSA-204005	8.539850e-01	0.069
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.550456e-01	0.068
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.550456e-01	0.068
Pyroptosis	R-HSA-5620971	8.550456e-01	0.068
Regulation of PTEN stability and activity	R-HSA-8948751	8.554400e-01	0.068
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.554400e-01	0.068
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.554400e-01	0.068
Amino acids regulate mTORC1	R-HSA-9639288	8.554400e-01	0.068
XBP1(S) activates chaperone genes	R-HSA-381038	8.558315e-01	0.068
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.582080e-01	0.066
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.589444e-01	0.066
Interleukin-1 signaling	R-HSA-9020702	8.593279e-01	0.066
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	8.599430e-01	0.066
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.599430e-01	0.066
Interleukin-2 signaling	R-HSA-9020558	8.599430e-01	0.066
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.599430e-01	0.066
Activated NTRK3 signals through RAS	R-HSA-9034864	8.599430e-01	0.066
Ionotropic activity of kainate receptors	R-HSA-451306	8.599430e-01	0.066
vRNA Synthesis	R-HSA-192814	8.599430e-01	0.066
Hormone ligand-binding receptors	R-HSA-375281	8.599430e-01	0.066
RHOBTB3 ATPase cycle	R-HSA-9706019	8.599430e-01	0.066
Bicarbonate transporters	R-HSA-425381	8.599430e-01	0.066
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.599430e-01	0.066
LGI-ADAM interactions	R-HSA-5682910	8.599430e-01	0.066
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.599430e-01	0.066
Suppression of apoptosis	R-HSA-9635465	8.599430e-01	0.066
MHC class II antigen presentation	R-HSA-2132295	8.626626e-01	0.064
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	8.629898e-01	0.064
Regulation of mitotic cell cycle	R-HSA-453276	8.629898e-01	0.064
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.629898e-01	0.064
Nucleosome assembly	R-HSA-774815	8.638039e-01	0.064
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	8.638039e-01	0.064
Fanconi Anemia Pathway	R-HSA-6783310	8.638039e-01	0.064
Platelet Aggregation (Plug Formation)	R-HSA-76009	8.638039e-01	0.064
Collagen chain trimerization	R-HSA-8948216	8.641170e-01	0.063
PI-3K cascade:FGFR4	R-HSA-5654720	8.652292e-01	0.063
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.652292e-01	0.063
Creatine metabolism	R-HSA-71288	8.652292e-01	0.063
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	8.652292e-01	0.063
Nephrin family interactions	R-HSA-373753	8.652292e-01	0.063
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.654360e-01	0.063
Interleukin-1 family signaling	R-HSA-446652	8.671349e-01	0.062
Signaling by FGFR2	R-HSA-5654738	8.673152e-01	0.062
Late endosomal microautophagy	R-HSA-9615710	8.680303e-01	0.061
Termination of translesion DNA synthesis	R-HSA-5656169	8.680303e-01	0.061
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.680303e-01	0.061
DARPP-32 events	R-HSA-180024	8.680303e-01	0.061
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.689683e-01	0.061
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.731860e-01	0.059
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.748511e-01	0.058
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.751668e-01	0.058
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.782979e-01	0.056
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.782979e-01	0.056
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.782979e-01	0.056
Activated NTRK2 signals through RAS	R-HSA-9026519	8.782979e-01	0.056
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.782979e-01	0.056
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.782979e-01	0.056
DS-GAG biosynthesis	R-HSA-2022923	8.782979e-01	0.056
Integration of provirus	R-HSA-162592	8.782979e-01	0.056
Signalling to RAS	R-HSA-167044	8.792503e-01	0.056
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.796467e-01	0.056
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.806659e-01	0.055
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.835312e-01	0.054
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	8.835312e-01	0.054
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.837077e-01	0.054
Signaling by FGFR1	R-HSA-5654736	8.837077e-01	0.054
Ion homeostasis	R-HSA-5578775	8.837077e-01	0.054
Stabilization of p53	R-HSA-69541	8.854303e-01	0.053
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.854303e-01	0.053
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.909517e-01	0.050
Budding and maturation of HIV virion	R-HSA-162588	8.909517e-01	0.050
Downstream signal transduction	R-HSA-186763	8.909517e-01	0.050
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.909517e-01	0.050
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	8.919123e-01	0.050
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.919123e-01	0.050
Molybdenum cofactor biosynthesis	R-HSA-947581	8.919123e-01	0.050
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.919123e-01	0.050
Glutathione synthesis and recycling	R-HSA-174403	8.919123e-01	0.050
Mitochondrial calcium ion transport	R-HSA-8949215	8.919123e-01	0.050
Assembly Of The HIV Virion	R-HSA-175474	8.919123e-01	0.050
GRB2 events in EGFR signaling	R-HSA-179812	8.942482e-01	0.049
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.942482e-01	0.049
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.942482e-01	0.049
SHC-related events triggered by IGF1R	R-HSA-2428933	8.942482e-01	0.049
OAS antiviral response	R-HSA-8983711	8.942482e-01	0.049
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.949497e-01	0.048
Interleukin-2 family signaling	R-HSA-451927	8.949497e-01	0.048
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	8.993527e-01	0.046
Chromosome Maintenance	R-HSA-73886	9.005316e-01	0.046
DNA Damage Bypass	R-HSA-73893	9.007590e-01	0.045
Degradation of CDH1	R-HSA-9766229	9.007590e-01	0.045
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.010176e-01	0.045
PI-3K cascade:FGFR1	R-HSA-5654689	9.033304e-01	0.044
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.033304e-01	0.044
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.033304e-01	0.044
Signaling by KIT in disease	R-HSA-9669938	9.033304e-01	0.044
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.033304e-01	0.044
Ethanol oxidation	R-HSA-71384	9.033304e-01	0.044
LDL clearance	R-HSA-8964038	9.033304e-01	0.044
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.037665e-01	0.044
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.037665e-01	0.044
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	9.081089e-01	0.042
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.081089e-01	0.042
Processing of SMDT1	R-HSA-8949664	9.081089e-01	0.042
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	9.081089e-01	0.042
Maturation of nucleoprotein	R-HSA-9683610	9.081089e-01	0.042
Interleukin-6 signaling	R-HSA-1059683	9.081089e-01	0.042
Replication of the SARS-CoV-1 genome	R-HSA-9682706	9.081089e-01	0.042
Regulation of RAS by GAPs	R-HSA-5658442	9.085105e-01	0.042
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.090025e-01	0.041
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.102371e-01	0.041
G-protein beta:gamma signalling	R-HSA-397795	9.102371e-01	0.041
FGFR1 mutant receptor activation	R-HSA-1839124	9.102371e-01	0.041
Integrin signaling	R-HSA-354192	9.102371e-01	0.041
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.103595e-01	0.041
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.103595e-01	0.041
Stimuli-sensing channels	R-HSA-2672351	9.103595e-01	0.041
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.119218e-01	0.040
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.119218e-01	0.040
Termination of O-glycan biosynthesis	R-HSA-977068	9.136132e-01	0.039
Carnitine shuttle	R-HSA-200425	9.136132e-01	0.039
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.136132e-01	0.039
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.136132e-01	0.039
Syndecan interactions	R-HSA-3000170	9.136132e-01	0.039
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.136132e-01	0.039
Formation of the ureteric bud	R-HSA-9830674	9.136132e-01	0.039
Hedgehog ligand biogenesis	R-HSA-5358346	9.157266e-01	0.038
Striated Muscle Contraction	R-HSA-390522	9.186697e-01	0.037
Effects of PIP2 hydrolysis	R-HSA-114508	9.186697e-01	0.037
Miscellaneous transport and binding events	R-HSA-5223345	9.186697e-01	0.037
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.196871e-01	0.036
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.201536e-01	0.036
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	9.201536e-01	0.036
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	9.201536e-01	0.036
NRIF signals cell death from the nucleus	R-HSA-205043	9.201536e-01	0.036
cGMP effects	R-HSA-418457	9.201536e-01	0.036
Malate-aspartate shuttle	R-HSA-9856872	9.201536e-01	0.036
Non-canonical inflammasome activation	R-HSA-9686114	9.201536e-01	0.036
HDL assembly	R-HSA-8963896	9.201536e-01	0.036
P2Y receptors	R-HSA-417957	9.201536e-01	0.036
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	9.201536e-01	0.036
IRS-related events triggered by IGF1R	R-HSA-2428928	9.204136e-01	0.036
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.224365e-01	0.035
Mitochondrial RNA degradation	R-HSA-9836573	9.228620e-01	0.035
TNFs bind their physiological receptors	R-HSA-5669034	9.228620e-01	0.035
Complex III assembly	R-HSA-9865881	9.228620e-01	0.035
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.252775e-01	0.034
Peptide chain elongation	R-HSA-156902	9.257747e-01	0.033
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.263728e-01	0.033
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.263728e-01	0.033
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.263728e-01	0.033
Mitophagy	R-HSA-5205647	9.263728e-01	0.033
NPAS4 regulates expression of target genes	R-HSA-9768919	9.263728e-01	0.033
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.267107e-01	0.033
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	9.306201e-01	0.031
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.306201e-01	0.031
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	9.306201e-01	0.031
ERBB2 Regulates Cell Motility	R-HSA-6785631	9.306201e-01	0.031
Protein lipoylation	R-HSA-9857492	9.306201e-01	0.031
Sema3A PAK dependent Axon repulsion	R-HSA-399954	9.306201e-01	0.031
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	9.306201e-01	0.031
SHC1 events in EGFR signaling	R-HSA-180336	9.306201e-01	0.031
DNA Damage Reversal	R-HSA-73942	9.306201e-01	0.031
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	9.306201e-01	0.031
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	9.306201e-01	0.031
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	9.306201e-01	0.031
p38MAPK events	R-HSA-171007	9.306201e-01	0.031
Other semaphorin interactions	R-HSA-416700	9.306201e-01	0.031
Protein methylation	R-HSA-8876725	9.306201e-01	0.031
PI-3K cascade:FGFR2	R-HSA-5654695	9.311712e-01	0.031
Activation of G protein gated Potassium channels	R-HSA-1296041	9.311712e-01	0.031
G protein gated Potassium channels	R-HSA-1296059	9.311712e-01	0.031
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.311712e-01	0.031
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.311712e-01	0.031
Formation of the nephric duct	R-HSA-9830364	9.311712e-01	0.031
COPI-mediated anterograde transport	R-HSA-6807878	9.313417e-01	0.031
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.313417e-01	0.031
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.319845e-01	0.031
DAP12 interactions	R-HSA-2172127	9.328115e-01	0.030
Amine ligand-binding receptors	R-HSA-375280	9.328115e-01	0.030
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.334007e-01	0.030
Cellular response to starvation	R-HSA-9711097	9.334489e-01	0.030
Translation initiation complex formation	R-HSA-72649	9.344502e-01	0.029
Base Excision Repair	R-HSA-73884	9.352314e-01	0.029
SLC transporter disorders	R-HSA-5619102	9.356110e-01	0.029
Toll-like Receptor Cascades	R-HSA-168898	9.358626e-01	0.029
IGF1R signaling cascade	R-HSA-2428924	9.371916e-01	0.028
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.371916e-01	0.028
SARS-CoV Infections	R-HSA-9679506	9.377144e-01	0.028
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.386281e-01	0.028
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.386281e-01	0.028
Attachment of bacteria to epithelial cells	R-HSA-9638630	9.386281e-01	0.028
Urea cycle	R-HSA-70635	9.386281e-01	0.028
Suppression of phagosomal maturation	R-HSA-9637687	9.386281e-01	0.028
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.386281e-01	0.028
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.387076e-01	0.027
Asymmetric localization of PCP proteins	R-HSA-4608870	9.387076e-01	0.027
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.395537e-01	0.027
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.397152e-01	0.027
Class I peroxisomal membrane protein import	R-HSA-9603798	9.397152e-01	0.027
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	9.397152e-01	0.027
Phase 4 - resting membrane potential	R-HSA-5576886	9.397152e-01	0.027
WNT5A-dependent internalization of FZD4	R-HSA-5099900	9.397152e-01	0.027
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.397152e-01	0.027
Fructose catabolism	R-HSA-70350	9.397152e-01	0.027
Regulation of NF-kappa B signaling	R-HSA-9758274	9.397152e-01	0.027
Mineralocorticoid biosynthesis	R-HSA-193993	9.397152e-01	0.027
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.398052e-01	0.027
Lysosome Vesicle Biogenesis	R-HSA-432720	9.398052e-01	0.027
FGFR2 mutant receptor activation	R-HSA-1839126	9.398052e-01	0.027
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.420410e-01	0.026
HCMV Infection	R-HSA-9609646	9.430826e-01	0.025
Ribosomal scanning and start codon recognition	R-HSA-72702	9.447694e-01	0.025
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.453133e-01	0.024
Packaging Of Telomere Ends	R-HSA-171306	9.453133e-01	0.024
Cristae formation	R-HSA-8949613	9.453133e-01	0.024
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.453133e-01	0.024
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.453133e-01	0.024
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.456350e-01	0.024
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.456350e-01	0.024
Cleavage of the damaged purine	R-HSA-110331	9.456350e-01	0.024
Cellular response to chemical stress	R-HSA-9711123	9.472086e-01	0.024
Eukaryotic Translation Elongation	R-HSA-156842	9.474471e-01	0.023
G beta:gamma signalling through CDC42	R-HSA-8964616	9.476184e-01	0.023
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.476184e-01	0.023
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.476184e-01	0.023
Coenzyme A biosynthesis	R-HSA-196783	9.476184e-01	0.023
Passive transport by Aquaporins	R-HSA-432047	9.476184e-01	0.023
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.476184e-01	0.023
Scavenging by Class B Receptors	R-HSA-3000471	9.476184e-01	0.023
MAPK6/MAPK4 signaling	R-HSA-5687128	9.479039e-01	0.023
SARS-CoV-2 Infection	R-HSA-9694516	9.479847e-01	0.023
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.491085e-01	0.023
IRS-mediated signalling	R-HSA-112399	9.493576e-01	0.023
Regulation of CDH1 Function	R-HSA-9764561	9.493576e-01	0.023
Depurination	R-HSA-73927	9.509361e-01	0.022
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.513010e-01	0.022
Phase 0 - rapid depolarisation	R-HSA-5576892	9.513010e-01	0.022
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.513010e-01	0.022
Inflammasomes	R-HSA-622312	9.513010e-01	0.022
Eukaryotic Translation Initiation	R-HSA-72613	9.514933e-01	0.022
Cap-dependent Translation Initiation	R-HSA-72737	9.514933e-01	0.022
ER to Golgi Anterograde Transport	R-HSA-199977	9.520293e-01	0.021
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.535971e-01	0.021
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.544860e-01	0.020
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	9.544860e-01	0.020
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.544860e-01	0.020
Catecholamine biosynthesis	R-HSA-209905	9.544860e-01	0.020
Glycogen storage diseases	R-HSA-3229121	9.544860e-01	0.020
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.544860e-01	0.020
Plasma lipoprotein clearance	R-HSA-8964043	9.557515e-01	0.020
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.557515e-01	0.020
Thyroxine biosynthesis	R-HSA-209968	9.566592e-01	0.019
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.566592e-01	0.019
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.566592e-01	0.019
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.566592e-01	0.019
Platelet calcium homeostasis	R-HSA-418360	9.566592e-01	0.019
Glucagon-type ligand receptors	R-HSA-420092	9.566592e-01	0.019
Triglyceride metabolism	R-HSA-8979227	9.575106e-01	0.019
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.582568e-01	0.019
Chaperonin-mediated protein folding	R-HSA-390466	9.583530e-01	0.018
Generation of second messenger molecules	R-HSA-202433	9.601214e-01	0.018
Attenuation phase	R-HSA-3371568	9.601214e-01	0.018
Diseases of Immune System	R-HSA-5260271	9.601214e-01	0.018
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.601214e-01	0.018
GAB1 signalosome	R-HSA-180292	9.604535e-01	0.018
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.604535e-01	0.018
PKA activation	R-HSA-163615	9.604535e-01	0.018
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.604535e-01	0.018
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.604535e-01	0.018
Vitamin D (calciferol) metabolism	R-HSA-196791	9.604535e-01	0.018
Formation of a pool of free 40S subunits	R-HSA-72689	9.605523e-01	0.017
Eukaryotic Translation Termination	R-HSA-72764	9.605523e-01	0.017
SHC1 events in ERBB2 signaling	R-HSA-1250196	9.614498e-01	0.017
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.614498e-01	0.017
PI3K Cascade	R-HSA-109704	9.617018e-01	0.017
Maturation of spike protein	R-HSA-9694548	9.640833e-01	0.016
PLC beta mediated events	R-HSA-112043	9.644457e-01	0.016
Activation of NF-kappaB in B cells	R-HSA-1169091	9.652113e-01	0.015
Beta-catenin independent WNT signaling	R-HSA-3858494	9.654039e-01	0.015
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.656389e-01	0.015
Pyrimidine biosynthesis	R-HSA-500753	9.656389e-01	0.015
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	9.656389e-01	0.015
Diseases of hemostasis	R-HSA-9671793	9.656389e-01	0.015
Maturation of nucleoprotein	R-HSA-9694631	9.656389e-01	0.015
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.656389e-01	0.015
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.656389e-01	0.015
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.657297e-01	0.015
Cargo concentration in the ER	R-HSA-5694530	9.657297e-01	0.015
Telomere Maintenance	R-HSA-157579	9.659374e-01	0.015
Mitochondrial protein import	R-HSA-1268020	9.675077e-01	0.014
NCAM signaling for neurite out-growth	R-HSA-375165	9.675077e-01	0.014
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.675843e-01	0.014
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.676722e-01	0.014
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.676722e-01	0.014
Intra-Golgi traffic	R-HSA-6811438	9.676722e-01	0.014
Signaling by FGFR	R-HSA-190236	9.683733e-01	0.014
Uptake and actions of bacterial toxins	R-HSA-5339562	9.684196e-01	0.014
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.693921e-01	0.014
Ribosome-associated quality control	R-HSA-9948299	9.695221e-01	0.013
Inwardly rectifying K+ channels	R-HSA-1296065	9.695503e-01	0.013
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.695503e-01	0.013
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.695503e-01	0.013
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.699793e-01	0.013
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.701446e-01	0.013
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.701446e-01	0.013
Glycogen synthesis	R-HSA-3322077	9.701446e-01	0.013
Pregnenolone biosynthesis	R-HSA-196108	9.701446e-01	0.013
Signal transduction by L1	R-HSA-445144	9.701446e-01	0.013
Ion channel transport	R-HSA-983712	9.705242e-01	0.013
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.707575e-01	0.013
Unfolded Protein Response (UPR)	R-HSA-381119	9.714123e-01	0.013
Autophagy	R-HSA-9612973	9.718939e-01	0.012
Insulin receptor signalling cascade	R-HSA-74751	9.729134e-01	0.012
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.729585e-01	0.012
Recycling of bile acids and salts	R-HSA-159418	9.729585e-01	0.012
Protein folding	R-HSA-391251	9.737944e-01	0.012
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.738576e-01	0.012
Response of Mtb to phagocytosis	R-HSA-9637690	9.738576e-01	0.012
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.740597e-01	0.011
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.740597e-01	0.011
Basigin interactions	R-HSA-210991	9.740597e-01	0.011
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.740597e-01	0.011
Early Phase of HIV Life Cycle	R-HSA-162594	9.740597e-01	0.011
Selenocysteine synthesis	R-HSA-2408557	9.747643e-01	0.011
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.749633e-01	0.011
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.749633e-01	0.011
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.752911e-01	0.011
Cytokine Signaling in Immune system	R-HSA-1280215	9.757346e-01	0.011
Glucagon signaling in metabolic regulation	R-HSA-163359	9.759967e-01	0.011
Vpu mediated degradation of CD4	R-HSA-180534	9.759967e-01	0.011
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.759967e-01	0.011
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.771705e-01	0.010
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.774616e-01	0.010
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.774616e-01	0.010
Androgen biosynthesis	R-HSA-193048	9.774616e-01	0.010
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.774732e-01	0.010
Viral mRNA Translation	R-HSA-192823	9.783456e-01	0.010
Dual Incision in GG-NER	R-HSA-5696400	9.787034e-01	0.009
eNOS activation	R-HSA-203615	9.787034e-01	0.009
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.787034e-01	0.009
Calnexin/calreticulin cycle	R-HSA-901042	9.787034e-01	0.009
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.787034e-01	0.009
Hyaluronan metabolism	R-HSA-2142845	9.787034e-01	0.009
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.789080e-01	0.009
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.789080e-01	0.009
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.789080e-01	0.009
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.789080e-01	0.009
G-protein mediated events	R-HSA-112040	9.794742e-01	0.009
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.804176e-01	0.009
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.804176e-01	0.009
Reactions specific to the complex N-glycan synthesis pathway	R-HSA-975578	9.804176e-01	0.009
Fructose metabolism	R-HSA-5652084	9.804176e-01	0.009
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.804176e-01	0.009
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.807766e-01	0.008
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.810701e-01	0.008
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.811131e-01	0.008
PERK regulates gene expression	R-HSA-381042	9.811131e-01	0.008
Regulation of Apoptosis	R-HSA-169911	9.811131e-01	0.008
Selective autophagy	R-HSA-9663891	9.822629e-01	0.008
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.829860e-01	0.007
Mitochondrial mRNA modification	R-HSA-9937008	9.829860e-01	0.007
Organic anion transport by SLCO transporters	R-HSA-879518	9.829860e-01	0.007
Synthesis of PC	R-HSA-1483191	9.830195e-01	0.007
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.831108e-01	0.007
HSF1 activation	R-HSA-3371511	9.832573e-01	0.007
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.832573e-01	0.007
Extension of Telomeres	R-HSA-180786	9.842221e-01	0.007
Neurotransmitter release cycle	R-HSA-112310	9.850482e-01	0.007
Degradation of DVL	R-HSA-4641258	9.851641e-01	0.006
NCAM1 interactions	R-HSA-419037	9.851641e-01	0.006
SLC-mediated transport of organic cations	R-HSA-549127	9.851641e-01	0.006
Metabolism of folate and pterines	R-HSA-196757	9.851641e-01	0.006
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	9.852177e-01	0.006
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.852177e-01	0.006
Thromboxane signalling through TP receptor	R-HSA-428930	9.852177e-01	0.006
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.852177e-01	0.006
Plasma lipoprotein assembly	R-HSA-8963898	9.852177e-01	0.006
Interleukin-6 family signaling	R-HSA-6783589	9.852177e-01	0.006
Leishmania phagocytosis	R-HSA-9664417	9.854984e-01	0.006
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.854984e-01	0.006
Parasite infection	R-HSA-9664407	9.854984e-01	0.006
RAB geranylgeranylation	R-HSA-8873719	9.857426e-01	0.006
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.857426e-01	0.006
SARS-CoV-1 Infection	R-HSA-9678108	9.859847e-01	0.006
Macroautophagy	R-HSA-1632852	9.864848e-01	0.006
Biofilm formation	R-HSA-9931953	9.868589e-01	0.006
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.868589e-01	0.006
Aquaporin-mediated transport	R-HSA-445717	9.871231e-01	0.006
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.871567e-01	0.006
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.871567e-01	0.006
Hyaluronan degradation	R-HSA-2160916	9.871567e-01	0.006
Alpha-oxidation of phytanate	R-HSA-389599	9.871567e-01	0.006
Vesicle-mediated transport	R-HSA-5653656	9.872469e-01	0.006
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.883644e-01	0.005
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.883644e-01	0.005
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.883757e-01	0.005
Signaling by PDGF	R-HSA-186797	9.883757e-01	0.005
TCR signaling	R-HSA-202403	9.884835e-01	0.005
Aggrephagy	R-HSA-9646399	9.897013e-01	0.004
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.897013e-01	0.004
C-type lectin receptors (CLRs)	R-HSA-5621481	9.899636e-01	0.004
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.902098e-01	0.004
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.903054e-01	0.004
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.903054e-01	0.004
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.903054e-01	0.004
Triglyceride biosynthesis	R-HSA-75109	9.903054e-01	0.004
Synthesis of PE	R-HSA-1483213	9.903054e-01	0.004
Insulin processing	R-HSA-264876	9.903054e-01	0.004
Collagen formation	R-HSA-1474290	9.903278e-01	0.004
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.903278e-01	0.004
Phospholipid metabolism	R-HSA-1483257	9.906237e-01	0.004
Hh mutants are degraded by ERAD	R-HSA-5362768	9.908877e-01	0.004
Opioid Signalling	R-HSA-111885	9.909862e-01	0.004
Interleukin-12 signaling	R-HSA-9020591	9.913215e-01	0.004
Telomere Extension By Telomerase	R-HSA-171319	9.915773e-01	0.004
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.915773e-01	0.004
Insulin receptor recycling	R-HSA-77387	9.915773e-01	0.004
Iron assimilation using enterobactin	R-HSA-9638334	9.915773e-01	0.004
Pyrimidine salvage	R-HSA-73614	9.915773e-01	0.004
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.918118e-01	0.004
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.919401e-01	0.004
Heme biosynthesis	R-HSA-189451	9.919401e-01	0.004
Scavenging by Class A Receptors	R-HSA-3000480	9.919401e-01	0.004
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.921701e-01	0.003
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.926824e-01	0.003
Regulation of gene expression in beta cells	R-HSA-210745	9.926824e-01	0.003
PCP/CE pathway	R-HSA-4086400	9.928705e-01	0.003
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.928734e-01	0.003
GABA B receptor activation	R-HSA-977444	9.928734e-01	0.003
Activation of GABAB receptors	R-HSA-991365	9.928734e-01	0.003
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.930021e-01	0.003
G alpha (z) signalling events	R-HSA-418597	9.930021e-01	0.003
Platelet homeostasis	R-HSA-418346	9.930313e-01	0.003
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.930398e-01	0.003
Kidney development	R-HSA-9830369	9.930805e-01	0.003
Signaling by Interleukins	R-HSA-449147	9.930996e-01	0.003
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.932569e-01	0.003
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.936426e-01	0.003
Neurotransmitter clearance	R-HSA-112311	9.936426e-01	0.003
Metabolism of amine-derived hormones	R-HSA-209776	9.937482e-01	0.003
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.937482e-01	0.003
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.937707e-01	0.003
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.940847e-01	0.003
Downstream TCR signaling	R-HSA-202424	9.941689e-01	0.003
Dectin-2 family	R-HSA-5621480	9.944170e-01	0.002
Proteasome assembly	R-HSA-9907900	9.944334e-01	0.002
Surfactant metabolism	R-HSA-5683826	9.944334e-01	0.002
Aspartate and asparagine metabolism	R-HSA-8963693	9.944768e-01	0.002
Amyloid fiber formation	R-HSA-977225	9.947088e-01	0.002
Platelet degranulation	R-HSA-114608	9.949393e-01	0.002
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.950824e-01	0.002
Integration of energy metabolism	R-HSA-163685	9.953549e-01	0.002
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.954665e-01	0.002
Peroxisomal protein import	R-HSA-9033241	9.955526e-01	0.002
Signaling by Insulin receptor	R-HSA-74752	9.956205e-01	0.002
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.956570e-01	0.002
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.956570e-01	0.002
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.958313e-01	0.002
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.960223e-01	0.002
Signaling by Retinoic Acid	R-HSA-5362517	9.960328e-01	0.002
Acyl chain remodelling of PC	R-HSA-1482788	9.963784e-01	0.002
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.964355e-01	0.002
Endogenous sterols	R-HSA-211976	9.964624e-01	0.002
GPER1 signaling	R-HSA-9634597	9.966154e-01	0.001
Interferon gamma signaling	R-HSA-877300	9.967011e-01	0.001
Signal amplification	R-HSA-392518	9.968538e-01	0.001
RA biosynthesis pathway	R-HSA-5365859	9.968538e-01	0.001
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.968538e-01	0.001
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.970133e-01	0.001
Gap junction trafficking and regulation	R-HSA-157858	9.970133e-01	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.970133e-01	0.001
Protein ubiquitination	R-HSA-8852135	9.970485e-01	0.001
Citric acid cycle (TCA cycle)	R-HSA-71403	9.970485e-01	0.001
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.971793e-01	0.001
Acyl chain remodelling of PE	R-HSA-1482839	9.972667e-01	0.001
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.972667e-01	0.001
Transferrin endocytosis and recycling	R-HSA-917977	9.972667e-01	0.001
Interferon alpha/beta signaling	R-HSA-909733	9.973707e-01	0.001
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.973707e-01	0.001
Interleukin-12 family signaling	R-HSA-447115	9.973987e-01	0.001
Protein localization	R-HSA-9609507	9.975730e-01	0.001
Translation of Structural Proteins	R-HSA-9694635	9.976238e-01	0.001
Glycosphingolipid transport	R-HSA-9845576	9.976255e-01	0.001
Disorders of transmembrane transporters	R-HSA-5619115	9.976674e-01	0.001
Transport to the Golgi and subsequent modification	R-HSA-948021	9.978020e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.978690e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.978690e-01	0.001
Voltage gated Potassium channels	R-HSA-1296072	9.979372e-01	0.001
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.979372e-01	0.001
Neddylation	R-HSA-8951664	9.979602e-01	0.001
Class B/2 (Secretin family receptors)	R-HSA-373080	9.980920e-01	0.001
Adaptive Immune System	R-HSA-1280218	9.981704e-01	0.001
Smooth Muscle Contraction	R-HSA-445355	9.981934e-01	0.001
tRNA processing in the mitochondrion	R-HSA-6785470	9.982080e-01	0.001
Extra-nuclear estrogen signaling	R-HSA-9009391	9.983553e-01	0.001
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.984433e-01	0.001
Pentose phosphate pathway	R-HSA-71336	9.984433e-01	0.001
FCERI mediated MAPK activation	R-HSA-2871796	9.984761e-01	0.001
rRNA processing in the mitochondrion	R-HSA-8868766	9.986477e-01	0.001
Glycogen metabolism	R-HSA-8982491	9.986477e-01	0.001
N-glycan antennae elongation in the medial/trans-Golgi	R-HSA-975576	9.986477e-01	0.001
Cardiac conduction	R-HSA-5576891	9.986502e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.987572e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.987669e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.988539e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.988952e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.988952e-01	0.000
Synthesis of PA	R-HSA-1483166	9.989111e-01	0.000
Transmission across Chemical Synapses	R-HSA-112315	9.989248e-01	0.000
Translation of Structural Proteins	R-HSA-9683701	9.989795e-01	0.000
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.990139e-01	0.000
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.990410e-01	0.000
Cytosolic tRNA aminoacylation	R-HSA-379716	9.991135e-01	0.000
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.991135e-01	0.000
Potassium Channels	R-HSA-1296071	9.991774e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.992121e-01	0.000
Developmental Cell Lineages	R-HSA-9734767	9.992226e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.992251e-01	0.000
GABA receptor activation	R-HSA-977443	9.992567e-01	0.000
Glutathione conjugation	R-HSA-156590	9.992567e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.992567e-01	0.000
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.993311e-01	0.000
Gap junction trafficking	R-HSA-190828	9.993311e-01	0.000
Methylation	R-HSA-156581	9.993311e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.993311e-01	0.000
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.994189e-01	0.000
Neuronal System	R-HSA-112316	9.994760e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.994935e-01	0.000
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.994953e-01	0.000
ABC transporter disorders	R-HSA-5619084	9.995189e-01	0.000
rRNA processing	R-HSA-72312	9.995559e-01	0.000
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.995616e-01	0.000
Viral Infection Pathways	R-HSA-9824446	9.996158e-01	0.000
Intraflagellar transport	R-HSA-5620924	9.996191e-01	0.000
Gluconeogenesis	R-HSA-70263	9.996191e-01	0.000
Metal ion SLC transporters	R-HSA-425410	9.996191e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.996425e-01	0.000
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.996425e-01	0.000
Platelet activation, signaling and aggregation	R-HSA-76002	9.996477e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.996970e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.996970e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.996970e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.997336e-01	0.000
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.997336e-01	0.000
Complex IV assembly	R-HSA-9864848	9.997504e-01	0.000
The phototransduction cascade	R-HSA-2514856	9.997504e-01	0.000
Nucleotide biosynthesis	R-HSA-8956320	9.998117e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.998192e-01	0.000
Regulation of insulin secretion	R-HSA-422356	9.998398e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.998549e-01	0.000
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.998579e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.998604e-01	0.000
ABC-family proteins mediated transport	R-HSA-382556	9.998729e-01	0.000
Iron uptake and transport	R-HSA-917937	9.998923e-01	0.000
Amino acid transport across the plasma membrane	R-HSA-352230	9.999191e-01	0.000
Muscle contraction	R-HSA-397014	9.999205e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999271e-01	0.000
Integrin cell surface interactions	R-HSA-216083	9.999271e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.999298e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.999360e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999360e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.999390e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999460e-01	0.000
Antigen processing-Cross presentation	R-HSA-1236975	9.999556e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.999600e-01	0.000
Glycosphingolipid biosynthesis	R-HSA-9840309	9.999600e-01	0.000
Xenobiotics	R-HSA-211981	9.999600e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999667e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999679e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999728e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.999738e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999785e-01	0.000
Leishmania infection	R-HSA-9658195	9.999809e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.999809e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999827e-01	0.000
ER-Phagosome pathway	R-HSA-1236974	9.999849e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999851e-01	0.000
Purine catabolism	R-HSA-74259	9.999871e-01	0.000
Hemostasis	R-HSA-109582	9.999900e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999935e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999940e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999954e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999954e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.999965e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999965e-01	0.000
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.999968e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999969e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999969e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999971e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999976e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999982e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999989e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999994e-01	0.000
FCGR activation	R-HSA-2029481	9.999995e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999998e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999998e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999999e-01	0.000
Keratinization	R-HSA-6805567	9.999999e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999999e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999999e-01	0.000
Neutrophil degranulation	R-HSA-6798695	9.999999e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999999e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999999e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	1.000000e+00	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	1.000000e+00	0.000
Leishmania parasite growth and survival	R-HSA-9664433	1.000000e+00	0.000
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Antimicrobial peptides	R-HSA-6803157	1.000000e+00	0.000
Extracellular matrix organization	R-HSA-1474244	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Immune System	R-HSA-168256	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Translation	R-HSA-72766	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Visual phototransduction	R-HSA-2187338	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	4.239725e-08	7.373
Chromatin organization	R-HSA-4839726	7.983058e-08	7.098
Cell Cycle, Mitotic	R-HSA-69278	1.808714e-06	5.743
Chromatin modifying enzymes	R-HSA-3247509	2.120868e-06	5.673
MITF-M-regulated melanocyte development	R-HSA-9730414	2.526351e-06	5.598
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.183827e-05	4.927
M Phase	R-HSA-68886	1.306624e-05	4.884
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.180131e-05	4.928
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.322275e-05	4.879
Nuclear Receptor transcription pathway	R-HSA-383280	1.786361e-05	4.748
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.264794e-05	4.645
Signaling by Hippo	R-HSA-2028269	4.025434e-05	4.395
Apoptotic execution phase	R-HSA-75153	4.514968e-05	4.345
Diseases of mitotic cell cycle	R-HSA-9675126	5.586721e-05	4.253
Mitotic Anaphase	R-HSA-68882	7.172753e-05	4.144
Mitotic Metaphase and Anaphase	R-HSA-2555396	7.840250e-05	4.106
Cell Cycle Checkpoints	R-HSA-69620	8.273452e-05	4.082
MITF-M-dependent gene expression	R-HSA-9856651	8.613875e-05	4.065
Gene expression (Transcription)	R-HSA-74160	1.236214e-04	3.908
Apoptosis	R-HSA-109581	1.349686e-04	3.870
Mitotic Prometaphase	R-HSA-68877	1.441255e-04	3.841
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.484965e-04	3.828
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.902611e-04	3.721
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.847963e-04	3.733
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.847963e-04	3.733
ISG15 antiviral mechanism	R-HSA-1169408	2.597652e-04	3.585
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.769961e-04	3.558
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.816196e-04	3.550
Cohesin Loading onto Chromatin	R-HSA-2470946	3.320627e-04	3.479
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.464097e-04	3.460
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.508911e-04	3.455
Nuclear Envelope Breakdown	R-HSA-2980766	3.568516e-04	3.448
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.851999e-04	3.414
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.001023e-04	3.398
Activation of BAD and translocation to mitochondria	R-HSA-111447	3.851999e-04	3.414
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.281629e-04	3.368
Nuclear import of Rev protein	R-HSA-180746	4.300046e-04	3.367
Interactions of Rev with host cellular proteins	R-HSA-177243	4.281629e-04	3.368
Regulation of TP53 Expression	R-HSA-6804754	5.141518e-04	3.289
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.179540e-04	3.286
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	5.179540e-04	3.286
snRNP Assembly	R-HSA-191859	4.923655e-04	3.308
Metabolism of non-coding RNA	R-HSA-194441	4.923655e-04	3.308
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.843611e-04	3.315
Activation of BH3-only proteins	R-HSA-114452	5.179540e-04	3.286
Regulation of PTEN gene transcription	R-HSA-8943724	5.752647e-04	3.240
SWI/SNF chromatin remodelers	R-HSA-9932451	6.086456e-04	3.216
ATP-dependent chromatin remodelers	R-HSA-9932444	6.086456e-04	3.216
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.466055e-04	3.189
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.466055e-04	3.189
Signal Transduction	R-HSA-162582	6.963680e-04	3.157
Separation of Sister Chromatids	R-HSA-2467813	7.037033e-04	3.153
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	7.167453e-04	3.145
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	9.542370e-04	3.020
IPs transport between nucleus and cytosol	R-HSA-1855170	9.843075e-04	3.007
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	9.985847e-04	3.001
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.066118e-03	2.972
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.146898e-03	2.940
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.201223e-03	2.920
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.280014e-03	2.893
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.380646e-03	2.860
Cellular Senescence	R-HSA-2559583	1.451327e-03	2.838
Programmed Cell Death	R-HSA-5357801	1.550703e-03	2.809
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.753406e-03	2.756
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.853063e-03	2.732
RNA Polymerase II Transcription	R-HSA-73857	1.857952e-03	2.731
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.868245e-03	2.729
Transcriptional regulation by RUNX1	R-HSA-8878171	2.039133e-03	2.691
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.177020e-03	2.662
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.155358e-03	2.666
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.293922e-03	2.639
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.496997e-03	2.603
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.173441e-03	2.498
Signaling by ALK in cancer	R-HSA-9700206	3.173441e-03	2.498
Epigenetic regulation of gene expression	R-HSA-212165	3.410079e-03	2.467
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.222252e-03	2.492
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.455434e-03	2.461
Transcriptional Regulation by E2F6	R-HSA-8953750	3.476946e-03	2.459
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.476946e-03	2.459
Signaling by LTK	R-HSA-9842663	3.557673e-03	2.449
G2/M DNA damage checkpoint	R-HSA-69473	3.694531e-03	2.432
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.070966e-03	2.390
Transcriptional Regulation by VENTX	R-HSA-8853884	4.743145e-03	2.324
PKMTs methylate histone lysines	R-HSA-3214841	4.743145e-03	2.324
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.743145e-03	2.324
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	4.752239e-03	2.323
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.752239e-03	2.323
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.250642e-03	2.280
G2/M Checkpoints	R-HSA-69481	5.745021e-03	2.241
Mitotic Prophase	R-HSA-68875	5.856751e-03	2.232
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.921469e-03	2.228
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.214336e-03	2.207
Cellular response to heat stress	R-HSA-3371556	6.355244e-03	2.197
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	6.214336e-03	2.207
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.135295e-03	2.212
Deadenylation of mRNA	R-HSA-429947	6.379517e-03	2.195
Mitotic Spindle Checkpoint	R-HSA-69618	6.583704e-03	2.182
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	6.823550e-03	2.166
Deubiquitination	R-HSA-5688426	6.919983e-03	2.160
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.048364e-03	2.152
Estrogen-dependent gene expression	R-HSA-9018519	7.055905e-03	2.151
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.603747e-03	2.119
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.760688e-03	2.110
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.856959e-03	2.105
Generic Transcription Pathway	R-HSA-212436	8.262017e-03	2.083
mRNA 3'-end processing	R-HSA-72187	9.156552e-03	2.038
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	9.525897e-03	2.021
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	9.525897e-03	2.021
MET interacts with TNS proteins	R-HSA-8875513	1.071872e-02	1.970
RNA Polymerase II Transcription Termination	R-HSA-73856	1.086272e-02	1.964
Viral Messenger RNA Synthesis	R-HSA-168325	1.086272e-02	1.964
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.081925e-02	1.966
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.087903e-02	1.963
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.101551e-02	1.958
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.122747e-02	1.950
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.195447e-02	1.922
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.208500e-02	1.918
p75 NTR receptor-mediated signalling	R-HSA-193704	1.218583e-02	1.914
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.344327e-02	1.871
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.344327e-02	1.871
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.250338e-02	1.903
Amplification of signal from the kinetochores	R-HSA-141424	1.250338e-02	1.903
Transcriptional Regulation by TP53	R-HSA-3700989	1.334507e-02	1.875
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.274310e-02	1.895
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.423804e-02	1.847
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.423804e-02	1.847
Diseases of Telomere Maintenance	R-HSA-9673013	1.423804e-02	1.847
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.423804e-02	1.847
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.423804e-02	1.847
mTORC1-mediated signalling	R-HSA-166208	1.430784e-02	1.844
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.449789e-02	1.839
NRAGE signals death through JNK	R-HSA-193648	1.449789e-02	1.839
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.553331e-02	1.809
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.625362e-02	1.789
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.614336e-02	1.792
MTOR signalling	R-HSA-165159	1.641682e-02	1.785
Specification of primordial germ cells	R-HSA-9827857	1.543610e-02	1.811
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.647061e-02	1.783
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.656346e-02	1.781
G1/S-Specific Transcription	R-HSA-69205	1.709810e-02	1.767
S Phase	R-HSA-69242	1.721995e-02	1.764
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.735070e-02	1.761
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.735070e-02	1.761
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.958247e-02	1.708
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.958247e-02	1.708
AURKA Activation by TPX2	R-HSA-8854518	1.816576e-02	1.741
Centrosome maturation	R-HSA-380287	1.988807e-02	1.701
mRNA Splicing - Major Pathway	R-HSA-72163	1.970288e-02	1.705
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.919994e-02	1.717
ESR-mediated signaling	R-HSA-8939211	1.804821e-02	1.744
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.804329e-02	1.744
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.804329e-02	1.744
SARS-CoV-2-host interactions	R-HSA-9705683	1.822178e-02	1.739
Neurodegenerative Diseases	R-HSA-8863678	1.997395e-02	1.700
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.997395e-02	1.700
G1 Phase	R-HSA-69236	2.082154e-02	1.681
Cyclin D associated events in G1	R-HSA-69231	2.082154e-02	1.681
UCH proteinases	R-HSA-5689603	2.172811e-02	1.663
Clathrin-mediated endocytosis	R-HSA-8856828	2.183308e-02	1.661
ALK mutants bind TKIs	R-HSA-9700645	2.385536e-02	1.622
GP1b-IX-V activation signalling	R-HSA-430116	2.385536e-02	1.622
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.385536e-02	1.622
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.426781e-02	1.615
Death Receptor Signaling	R-HSA-73887	2.474557e-02	1.607
G alpha (12/13) signalling events	R-HSA-416482	2.578714e-02	1.589
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.581831e-02	1.588
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.581831e-02	1.588
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.581831e-02	1.588
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.615427e-02	1.582
Heme signaling	R-HSA-9707616	2.655600e-02	1.576
Breakdown of the nuclear lamina	R-HSA-352238	3.021540e-02	1.520
Cell-extracellular matrix interactions	R-HSA-446353	2.961890e-02	1.528
Signal attenuation	R-HSA-74749	3.068027e-02	1.513
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.392633e-02	1.469
mRNA Splicing	R-HSA-72172	3.438812e-02	1.464
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.565929e-02	1.448
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	3.565929e-02	1.448
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.612573e-02	1.442
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.612573e-02	1.442
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.612573e-02	1.442
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	3.854190e-02	1.414
Membrane Trafficking	R-HSA-199991	3.973265e-02	1.401
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.087203e-02	1.389
SARS-CoV-1-host interactions	R-HSA-9692914	4.096416e-02	1.388
Notch-HLH transcription pathway	R-HSA-350054	4.236851e-02	1.373
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.605794e-02	1.337
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	4.240637e-02	1.373
Deadenylation-dependent mRNA decay	R-HSA-429914	4.226670e-02	1.374
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	4.741100e-02	1.324
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	4.605794e-02	1.337
Kinesins	R-HSA-983189	4.605794e-02	1.337
HATs acetylate histones	R-HSA-3214847	4.317055e-02	1.365
Ovarian tumor domain proteases	R-HSA-5689896	4.741100e-02	1.324
Interleukin-12 signaling	R-HSA-9020591	4.304540e-02	1.366
Regulation of NFE2L2 gene expression	R-HSA-9818749	4.823159e-02	1.317
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.865126e-02	1.313
Uptake and function of anthrax toxins	R-HSA-5210891	4.987139e-02	1.302
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.000259e-02	1.301
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	5.068739e-02	1.295
Cellular responses to stress	R-HSA-2262752	5.132050e-02	1.290
Oxidative Stress Induced Senescence	R-HSA-2559580	5.236366e-02	1.281
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.432168e-02	1.265
tRNA processing in the nucleus	R-HSA-6784531	5.432168e-02	1.265
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	6.205941e-02	1.207
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.205941e-02	1.207
SOS-mediated signalling	R-HSA-112412	6.205941e-02	1.207
MET activates RAS signaling	R-HSA-8851805	5.739962e-02	1.241
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.739962e-02	1.241
SHC-related events triggered by IGF1R	R-HSA-2428933	5.739962e-02	1.241
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.739962e-02	1.241
TGFBR3 expression	R-HSA-9839394	6.285395e-02	1.202
RUNX3 regulates WNT signaling	R-HSA-8951430	6.205941e-02	1.207
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.205941e-02	1.207
Regulation of TP53 Activity	R-HSA-5633007	5.537449e-02	1.257
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.447007e-02	1.191
HDMs demethylate histones	R-HSA-3214842	6.285395e-02	1.202
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.447007e-02	1.191
Recycling pathway of L1	R-HSA-437239	6.299039e-02	1.201
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	5.702804e-02	1.244
Transcriptional regulation by small RNAs	R-HSA-5578749	6.063010e-02	1.217
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.805951e-02	1.236
Inositol phosphate metabolism	R-HSA-1483249	5.910434e-02	1.228
Cellular responses to stimuli	R-HSA-8953897	6.488946e-02	1.188
Switching of origins to a post-replicative state	R-HSA-69052	6.514832e-02	1.186
Signaling by EGFR	R-HSA-177929	6.626766e-02	1.179
Transcriptional regulation by RUNX3	R-HSA-8878159	6.679605e-02	1.175
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	6.837554e-02	1.165
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	6.847817e-02	1.164
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	7.077985e-02	1.150
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.154518e-02	1.145
PTEN Regulation	R-HSA-6807070	7.428042e-02	1.129
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	7.476783e-02	1.126
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	7.476783e-02	1.126
FOXO-mediated transcription	R-HSA-9614085	7.520113e-02	1.124
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	7.538303e-02	1.123
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	7.538303e-02	1.123
Formation of definitive endoderm	R-HSA-9823730	7.659666e-02	1.116
Formation of annular gap junctions	R-HSA-196025	7.750639e-02	1.111
Loss of Function of TP53 in Cancer	R-HSA-9723907	8.565865e-02	1.067
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	8.565865e-02	1.067
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	8.565865e-02	1.067
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	8.565865e-02	1.067
Gap junction degradation	R-HSA-190873	9.445068e-02	1.025
WNT mediated activation of DVL	R-HSA-201688	9.445068e-02	1.025
Calcineurin activates NFAT	R-HSA-2025928	9.445068e-02	1.025
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	8.035035e-02	1.095
Erythropoietin activates RAS	R-HSA-9027284	9.328745e-02	1.030
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.692777e-02	1.061
Regulation of endogenous retroelements	R-HSA-9842860	8.905710e-02	1.050
G1/S Transition	R-HSA-69206	8.496851e-02	1.071
DCC mediated attractive signaling	R-HSA-418885	9.328745e-02	1.030
Oncogenic MAPK signaling	R-HSA-6802957	8.029614e-02	1.095
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	8.347642e-02	1.078
DNA Double Strand Break Response	R-HSA-5693606	7.912257e-02	1.102
Signaling by NOTCH1	R-HSA-1980143	8.000231e-02	1.097
Oncogene Induced Senescence	R-HSA-2559585	8.702127e-02	1.060
Circadian clock	R-HSA-9909396	7.942356e-02	1.100
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.925409e-02	1.101
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.702127e-02	1.060
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	9.445068e-02	1.025
Unwinding of DNA	R-HSA-176974	9.445068e-02	1.025
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.827176e-02	1.054
XBP1(S) activates chaperone genes	R-HSA-381038	9.072115e-02	1.042
RET signaling	R-HSA-8853659	9.541723e-02	1.020
RUNX2 regulates bone development	R-HSA-8941326	9.541723e-02	1.020
Interleukin-12 family signaling	R-HSA-447115	9.623422e-02	1.017
Signaling by PDGFR in disease	R-HSA-9671555	9.794687e-02	1.009
Regulation of gap junction activity	R-HSA-191650	1.016892e-01	0.993
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	1.016892e-01	0.993
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.016892e-01	0.993
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.016892e-01	0.993
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.016892e-01	0.993
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.016892e-01	0.993
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.042453e-01	0.982
Axon guidance	R-HSA-422475	1.057765e-01	0.976
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.071420e-01	0.970
Prolonged ERK activation events	R-HSA-169893	1.071420e-01	0.970
Activation of the pre-replicative complex	R-HSA-68962	1.079031e-01	0.967
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.079031e-01	0.967
Drug-mediated inhibition of MET activation	R-HSA-9734091	1.639846e-01	0.785
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.639846e-01	0.785
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.639846e-01	0.785
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.639846e-01	0.785
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.639846e-01	0.785
Signaling by TCF7L2 mutants	R-HSA-5339700	2.356050e-01	0.628
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.356050e-01	0.628
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	2.356050e-01	0.628
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.356050e-01	0.628
IKBKB deficiency causes SCID	R-HSA-5602636	2.356050e-01	0.628
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	2.356050e-01	0.628
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	2.356050e-01	0.628
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.356050e-01	0.628
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.356050e-01	0.628
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	2.356050e-01	0.628
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.307888e-01	0.883
IRS activation	R-HSA-74713	1.307888e-01	0.883
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.307888e-01	0.883
G2 Phase	R-HSA-68911	1.307888e-01	0.883
Noncanonical activation of NOTCH3	R-HSA-9017802	1.614966e-01	0.792
IkBA variant leads to EDA-ID	R-HSA-5603029	1.614966e-01	0.792
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.614966e-01	0.792
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.010937e-01	0.521
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.010937e-01	0.521
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.010937e-01	0.521
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.010937e-01	0.521
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.010937e-01	0.521
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.010937e-01	0.521
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.010937e-01	0.521
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.010937e-01	0.521
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.010937e-01	0.521
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.010937e-01	0.521
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.010937e-01	0.521
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.010937e-01	0.521
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.010937e-01	0.521
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.010937e-01	0.521
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.010937e-01	0.521
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.010937e-01	0.521
MET activates RAP1 and RAC1	R-HSA-8875555	1.127575e-01	0.948
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	1.127575e-01	0.948
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.933239e-01	0.714
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.933239e-01	0.714
Activated NTRK3 signals through RAS	R-HSA-9034864	1.322840e-01	0.878
Activated NTRK2 signals through RAS	R-HSA-9026519	1.528834e-01	0.816
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.528834e-01	0.816
IFNG signaling activates MAPKs	R-HSA-9732724	2.258542e-01	0.646
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	2.258542e-01	0.646
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.258542e-01	0.646
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.609753e-01	0.443
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	3.609753e-01	0.443
Defective MMACHC causes MAHCC	R-HSA-3359474	3.609753e-01	0.443
Invadopodia formation	R-HSA-8941237	3.609753e-01	0.443
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	3.609753e-01	0.443
MET activates PTPN11	R-HSA-8865999	3.609753e-01	0.443
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	3.609753e-01	0.443
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.218623e-01	0.914
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.744085e-01	0.758
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.744085e-01	0.758
RUNX3 regulates p14-ARF	R-HSA-8951936	1.744085e-01	0.758
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.373910e-01	0.862
Type I hemidesmosome assembly	R-HSA-446107	2.587337e-01	0.587
Signaling by MRAS-complex mutants	R-HSA-9660537	2.587337e-01	0.587
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.587337e-01	0.587
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.967139e-01	0.706
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.536664e-01	0.813
TRAF6 mediated NF-kB activation	R-HSA-933542	1.349020e-01	0.870
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.196582e-01	0.658
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.916641e-01	0.535
ARMS-mediated activation	R-HSA-170984	2.916641e-01	0.535
HCN channels	R-HSA-1296061	4.157296e-01	0.381
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.157296e-01	0.381
Defective LFNG causes SCDO3	R-HSA-5083630	4.157296e-01	0.381
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.157296e-01	0.381
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.157296e-01	0.381
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	1.295784e-01	0.887
SHC1 events in EGFR signaling	R-HSA-180336	2.431057e-01	0.614
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.063118e-01	0.685
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.669274e-01	0.574
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.669274e-01	0.574
Phosphorylation of the APC/C	R-HSA-176412	2.669274e-01	0.574
Signaling downstream of RAS mutants	R-HSA-9649948	1.164220e-01	0.934
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.921221e-01	0.716
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	4.657952e-01	0.332
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	4.657952e-01	0.332
Defective F9 activation	R-HSA-9673221	4.657952e-01	0.332
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	4.657952e-01	0.332
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.657952e-01	0.332
DAP12 signaling	R-HSA-2424491	2.234733e-01	0.651
Interleukin receptor SHC signaling	R-HSA-912526	2.632465e-01	0.580
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.152168e-01	0.501
MET promotes cell motility	R-HSA-8875878	2.193121e-01	0.659
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.828596e-01	0.548
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	3.884693e-01	0.411
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.394667e-01	0.469
mRNA Splicing - Minor Pathway	R-HSA-72165	2.139209e-01	0.670
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.636559e-01	0.439
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.636559e-01	0.439
GRB2 events in EGFR signaling	R-HSA-179812	4.195026e-01	0.377
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.115735e-01	0.291
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.115735e-01	0.291
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.115735e-01	0.291
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.115735e-01	0.291
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.115735e-01	0.291
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.115735e-01	0.291
Defective CSF2RB causes SMDP5	R-HSA-5688849	5.115735e-01	0.291
Defective CSF2RA causes SMDP4	R-HSA-5688890	5.115735e-01	0.291
Signaling by RAF1 mutants	R-HSA-9656223	2.778875e-01	0.556
RAF activation	R-HSA-5673000	3.072020e-01	0.513
EPHA-mediated growth cone collapse	R-HSA-3928663	3.426997e-01	0.465
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.876972e-01	0.412
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.876972e-01	0.412
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.876972e-01	0.412
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.876972e-01	0.412
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.876972e-01	0.412
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.876972e-01	0.412
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	2.360759e-01	0.627
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	4.497103e-01	0.347
Orc1 removal from chromatin	R-HSA-68949	2.939400e-01	0.532
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.369343e-01	0.625
SHC-mediated cascade:FGFR3	R-HSA-5654704	4.115116e-01	0.386
Meiotic synapsis	R-HSA-1221632	3.079162e-01	0.512
Signaling by Erythropoietin	R-HSA-9006335	3.828374e-01	0.417
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	3.828374e-01	0.417
Impaired BRCA2 binding to RAD51	R-HSA-9709570	3.828374e-01	0.417
Nucleosome assembly	R-HSA-774815	3.395082e-01	0.469
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.395082e-01	0.469
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.063884e-01	0.514
SHC-mediated cascade:FGFR4	R-HSA-5654719	4.350288e-01	0.361
FGFR2 alternative splicing	R-HSA-6803529	4.581862e-01	0.339
Attenuation phase	R-HSA-3371568	4.119391e-01	0.385
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.792471e-01	0.421
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.073245e-01	0.295
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.073245e-01	0.295
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	3.781879e-01	0.422
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	4.809289e-01	0.318
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	4.618538e-01	0.335
HSF1-dependent transactivation	R-HSA-3371571	4.337217e-01	0.363
Processing of DNA double-strand break ends	R-HSA-5693607	4.032279e-01	0.394
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.257502e-01	0.371
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	4.493023e-01	0.347
Striated Muscle Contraction	R-HSA-390522	4.810954e-01	0.318
SHC-mediated cascade:FGFR1	R-HSA-5654688	5.032092e-01	0.298
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	5.032092e-01	0.298
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.346180e-01	0.272
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.647871e-01	0.333
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	4.647871e-01	0.333
Dual Incision in GG-NER	R-HSA-5696400	5.000598e-01	0.301
Translation initiation complex formation	R-HSA-72649	4.801555e-01	0.319
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.249863e-01	0.280
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	4.953882e-01	0.305
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.104670e-01	0.292
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.370390e-01	0.270
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	5.304598e-01	0.275
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.465614e-01	0.262
Signaling by EGFR in Cancer	R-HSA-1643713	5.462256e-01	0.263
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.028183e-01	0.395
RNA Polymerase III Transcription	R-HSA-74158	5.370390e-01	0.270
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.115116e-01	0.386
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.115116e-01	0.386
Signaling by NOTCH2	R-HSA-1980145	5.000598e-01	0.301
Nucleotide Excision Repair	R-HSA-5696398	1.098929e-01	0.959
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.218623e-01	0.914
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.152168e-01	0.501
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.152168e-01	0.501
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.394667e-01	0.469
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.481029e-01	0.605
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.481029e-01	0.605
G0 and Early G1	R-HSA-1538133	2.562157e-01	0.591
Sema4D in semaphorin signaling	R-HSA-400685	1.484244e-01	0.828
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.350288e-01	0.361
Signaling by MET	R-HSA-6806834	2.682603e-01	0.571
HCMV Early Events	R-HSA-9609690	1.168015e-01	0.933
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.249053e-01	0.648
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.234733e-01	0.651
EGFR downregulation	R-HSA-182971	2.396917e-01	0.620
Adipogenesis	R-HSA-9843745	1.177404e-01	0.929
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	5.032092e-01	0.298
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.562673e-01	0.591
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.624934e-01	0.789
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.828374e-01	0.417
Repression of WNT target genes	R-HSA-4641265	1.744085e-01	0.758
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.881948e-01	0.725
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.164220e-01	0.934
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.164220e-01	0.934
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.439062e-01	0.613
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.975233e-01	0.303
Frs2-mediated activation	R-HSA-170968	1.967139e-01	0.706
DNA Replication Pre-Initiation	R-HSA-69002	4.010137e-01	0.397
Apoptosis induced DNA fragmentation	R-HSA-140342	3.243957e-01	0.489
MAP2K and MAPK activation	R-HSA-5674135	1.545554e-01	0.811
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.730032e-01	0.564
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	4.293250e-01	0.367
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.218623e-01	0.914
Homology Directed Repair	R-HSA-5693538	2.991492e-01	0.524
Hedgehog 'off' state	R-HSA-5610787	2.959922e-01	0.529
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	2.587337e-01	0.587
Regulation of CDH11 function	R-HSA-9762292	3.243957e-01	0.489
PI3K/AKT activation	R-HSA-198203	3.243957e-01	0.489
Nuclear RNA decay	R-HSA-9930044	2.730032e-01	0.564
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.481029e-01	0.605
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.346180e-01	0.272
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.546224e-01	0.342
EPH-Ephrin signaling	R-HSA-2682334	3.096767e-01	0.509
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.000598e-01	0.301
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	5.104670e-01	0.292
Assembly of the pre-replicative complex	R-HSA-68867	3.205157e-01	0.494
Signaling by RAS mutants	R-HSA-6802949	1.164220e-01	0.934
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.000598e-01	0.301
Resolution of D-Loop Structures	R-HSA-5693537	4.810954e-01	0.318
Chromosome Maintenance	R-HSA-73886	5.490692e-01	0.260
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.656525e-01	0.332
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.307888e-01	0.883
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.614966e-01	0.792
NF-kB is activated and signals survival	R-HSA-209560	1.528834e-01	0.816
Activation of RAC1	R-HSA-428540	1.528834e-01	0.816
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.218623e-01	0.914
Formation of axial mesoderm	R-HSA-9796292	1.967139e-01	0.706
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.431057e-01	0.614
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.917442e-01	0.717
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.394667e-01	0.469
Integrin signaling	R-HSA-354192	2.730032e-01	0.564
E2F mediated regulation of DNA replication	R-HSA-113510	3.636559e-01	0.439
Regulation of IFNG signaling	R-HSA-877312	4.195026e-01	0.377
Signaling by MST1	R-HSA-8852405	5.115735e-01	0.291
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	3.220174e-01	0.492
Cyclin E associated events during G1/S transition	R-HSA-69202	3.990134e-01	0.399
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.618538e-01	0.335
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.014226e-01	0.696
Downstream signaling of activated FGFR3	R-HSA-5654708	3.828374e-01	0.417
Downstream signaling of activated FGFR4	R-HSA-5654716	4.028183e-01	0.395
Downstream signaling of activated FGFR2	R-HSA-5654696	5.187167e-01	0.285
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.439062e-01	0.613
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.226473e-01	0.491
EPHB-mediated forward signaling	R-HSA-3928662	3.239185e-01	0.490
Regulation of NF-kappa B signaling	R-HSA-9758274	5.346180e-01	0.272
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.441207e-01	0.841
Signaling by ERBB2	R-HSA-1227986	1.616892e-01	0.791
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	1.933239e-01	0.714
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.766304e-01	0.753
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	4.195026e-01	0.377
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.657669e-01	0.781
Gap junction trafficking and regulation	R-HSA-157858	2.529789e-01	0.597
Downstream signaling of activated FGFR1	R-HSA-5654687	5.187167e-01	0.285
DNA Double-Strand Break Repair	R-HSA-5693532	1.417523e-01	0.848
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.353524e-01	0.628
TP53 Regulates Metabolic Genes	R-HSA-5628897	3.625374e-01	0.441
IGF1R signaling cascade	R-HSA-2428924	4.653499e-01	0.332
Signaling by NOTCH	R-HSA-157118	1.387272e-01	0.858
Signaling by NOTCH3	R-HSA-9012852	1.176239e-01	0.930
Signaling by NOTCH4	R-HSA-9013694	2.054449e-01	0.687
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.934958e-01	0.532
Activation of NF-kappaB in B cells	R-HSA-1169091	4.337217e-01	0.363
Signalling to ERKs	R-HSA-187687	1.784882e-01	0.748
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.722909e-01	0.429
Late Phase of HIV Life Cycle	R-HSA-162599	1.959479e-01	0.708
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.218623e-01	0.914
Adrenoceptors	R-HSA-390696	2.587337e-01	0.587
Transport of connexons to the plasma membrane	R-HSA-190872	1.536664e-01	0.813
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	4.157296e-01	0.381
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.910022e-01	0.536
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.657952e-01	0.332
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.657952e-01	0.332
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.152168e-01	0.501
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	3.884693e-01	0.411
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.930796e-01	0.533
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.876972e-01	0.412
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.686060e-01	0.571
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.115116e-01	0.386
Synthesis of DNA	R-HSA-69239	2.738171e-01	0.563
Killing mechanisms	R-HSA-9664420	5.346180e-01	0.272
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.346180e-01	0.272
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.483267e-01	0.458
Signaling by FGFR1 in disease	R-HSA-5655302	4.466041e-01	0.350
Signaling by Nuclear Receptors	R-HSA-9006931	1.424557e-01	0.846
Gap junction trafficking	R-HSA-190828	3.239185e-01	0.490
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.794930e-01	0.319
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.080679e-01	0.389
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.080679e-01	0.389
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.080679e-01	0.389
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.080679e-01	0.389
DNA Replication	R-HSA-69306	4.640878e-01	0.333
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.462256e-01	0.263
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.660231e-01	0.575
FasL/ CD95L signaling	R-HSA-75157	3.609753e-01	0.443
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.587337e-01	0.587
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.157296e-01	0.381
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.157296e-01	0.381
HDACs deacetylate histones	R-HSA-3214815	1.176239e-01	0.930
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	4.657952e-01	0.332
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.115735e-01	0.291
DNA strand elongation	R-HSA-69190	4.423686e-01	0.354
Signaling by NODAL	R-HSA-1181150	3.876972e-01	0.412
Myogenesis	R-HSA-525793	1.624934e-01	0.789
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.884693e-01	0.411
Regulation of MECP2 expression and activity	R-HSA-9022692	2.730032e-01	0.564
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.079766e-01	0.682
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	3.226473e-01	0.491
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	4.810954e-01	0.318
Extra-nuclear estrogen signaling	R-HSA-9009391	2.105848e-01	0.677
Gap junction assembly	R-HSA-190861	5.000598e-01	0.301
Semaphorin interactions	R-HSA-373755	4.511191e-01	0.346
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	4.466041e-01	0.350
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.636559e-01	0.439
HCMV Infection	R-HSA-9609646	3.814678e-01	0.419
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.828596e-01	0.548
DAP12 interactions	R-HSA-2172127	4.975233e-01	0.303
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.231670e-01	0.910
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.882868e-01	0.540
p75NTR signals via NF-kB	R-HSA-193639	2.431057e-01	0.614
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.432004e-01	0.844
Regulation of beta-cell development	R-HSA-186712	2.556985e-01	0.592
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	4.226766e-01	0.374
Post NMDA receptor activation events	R-HSA-438064	3.594546e-01	0.444
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.076029e-01	0.683
Selective autophagy	R-HSA-9663891	2.570653e-01	0.590
Signaling by Hedgehog	R-HSA-5358351	5.232385e-01	0.281
Autophagy	R-HSA-9612973	3.923603e-01	0.406
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.293250e-01	0.367
HIV Life Cycle	R-HSA-162587	2.299167e-01	0.638
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.640055e-01	0.785
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.571122e-01	0.590
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.356050e-01	0.628
Transport of connexins along the secretory pathway	R-HSA-190827	2.356050e-01	0.628
MET activates STAT3	R-HSA-8875791	3.609753e-01	0.443
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.587337e-01	0.587
Regulation of KIT signaling	R-HSA-1433559	2.196582e-01	0.658
Inactivation of CDC42 and RAC1	R-HSA-428543	2.916641e-01	0.535
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.916641e-01	0.535
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	4.157296e-01	0.381
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.431057e-01	0.614
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.431057e-01	0.614
EGFR Transactivation by Gastrin	R-HSA-2179392	3.243957e-01	0.489
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	3.567209e-01	0.448
Reelin signalling pathway	R-HSA-8866376	4.657952e-01	0.332
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.100243e-01	0.959
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.394667e-01	0.469
Metalloprotease DUBs	R-HSA-5689901	3.226473e-01	0.491
TRAIL signaling	R-HSA-75158	5.115735e-01	0.291
Pentose phosphate pathway disease	R-HSA-6791465	5.115735e-01	0.291
Synthesis of PS	R-HSA-1483101	5.115735e-01	0.291
CDC6 association with the ORC:origin complex	R-HSA-68689	5.115735e-01	0.291
MAP kinase activation	R-HSA-450294	2.807387e-01	0.552
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.119391e-01	0.385
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.023604e-01	0.395
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.023604e-01	0.395
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.032092e-01	0.298
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.000598e-01	0.301
Metabolism of RNA	R-HSA-8953854	2.089754e-01	0.680
Macroautophagy	R-HSA-1632852	3.449999e-01	0.462
PIP3 activates AKT signaling	R-HSA-1257604	2.041488e-01	0.690
Hedgehog 'on' state	R-HSA-5632684	2.803499e-01	0.552
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.121386e-01	0.291
DNA Repair	R-HSA-73894	2.156239e-01	0.666
Ca-dependent events	R-HSA-111996	4.637477e-01	0.334
Signaling by TGFB family members	R-HSA-9006936	5.277755e-01	0.278
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.121386e-01	0.291
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.121386e-01	0.291
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.657017e-01	0.332
Cell junction organization	R-HSA-446728	1.722106e-01	0.764
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.922338e-01	0.534
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.069077e-01	0.684
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.069077e-01	0.684
Aggrephagy	R-HSA-9646399	1.332411e-01	0.875
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.574568e-01	0.803
Signaling by FGFR4 in disease	R-HSA-5655291	4.790061e-01	0.320
Regulation of TP53 Degradation	R-HSA-6804757	5.370390e-01	0.270
RAF/MAP kinase cascade	R-HSA-5673001	5.007296e-01	0.300
Intracellular signaling by second messengers	R-HSA-9006925	1.816695e-01	0.741
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.243957e-01	0.489
Interleukin-17 signaling	R-HSA-448424	3.990134e-01	0.399
RMTs methylate histone arginines	R-HSA-3214858	1.892183e-01	0.723
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.636559e-01	0.439
Adherens junctions interactions	R-HSA-418990	3.069457e-01	0.513
Cell-cell junction organization	R-HSA-421270	4.678913e-01	0.330
p75NTR recruits signalling complexes	R-HSA-209543	4.195026e-01	0.377
Golgi-to-ER retrograde transport	R-HSA-8856688	1.229684e-01	0.910
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.935330e-01	0.307
Nervous system development	R-HSA-9675108	1.205485e-01	0.919
Cell-Cell communication	R-HSA-1500931	2.051729e-01	0.688
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.805748e-01	0.743
Calmodulin induced events	R-HSA-111933	5.370390e-01	0.270
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.102882e-01	0.957
Signaling by PTK6	R-HSA-8848021	1.102882e-01	0.957
Diseases of programmed cell death	R-HSA-9645723	2.570653e-01	0.590
Rap1 signalling	R-HSA-392517	1.706234e-01	0.768
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.657952e-01	0.332
NRIF signals cell death from the nucleus	R-HSA-205043	4.790061e-01	0.320
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.824350e-01	0.317
Developmental Biology	R-HSA-1266738	3.044950e-01	0.516
MAPK1/MAPK3 signaling	R-HSA-5684996	5.483134e-01	0.261
HIV Infection	R-HSA-162906	4.537397e-01	0.343
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.498624e-01	0.824
Evasion by RSV of host interferon responses	R-HSA-9833109	4.226766e-01	0.374
CaM pathway	R-HSA-111997	5.370390e-01	0.270
Mitochondrial biogenesis	R-HSA-1592230	5.076510e-01	0.294
Gastrulation	R-HSA-9758941	1.762247e-01	0.754
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.186029e-01	0.660
Reproduction	R-HSA-1474165	4.351362e-01	0.361
Vesicle-mediated transport	R-HSA-5653656	5.278776e-01	0.277
Regulated proteolysis of p75NTR	R-HSA-193692	2.916641e-01	0.535
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	2.916641e-01	0.535
Formation of intermediate mesoderm	R-HSA-9761174	3.243957e-01	0.489
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	2.439062e-01	0.613
Disorders of Nervous System Development	R-HSA-9697154	4.195026e-01	0.377
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.195026e-01	0.377
Pervasive developmental disorders	R-HSA-9005895	4.195026e-01	0.377
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.115735e-01	0.291
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.115116e-01	0.386
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.581862e-01	0.339
Rab regulation of trafficking	R-HSA-9007101	3.931586e-01	0.405
G1/S DNA Damage Checkpoints	R-HSA-69615	4.511191e-01	0.346
Protein folding	R-HSA-391251	4.302903e-01	0.366
DAG and IP3 signaling	R-HSA-1489509	5.141073e-01	0.289
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.368170e-01	0.360
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.249863e-01	0.280
Cellular responses to mechanical stimuli	R-HSA-9855142	4.546224e-01	0.342
Acyl chain remodelling of PS	R-HSA-1482801	3.026807e-01	0.519
Smooth Muscle Contraction	R-HSA-445355	4.647871e-01	0.333
MAPK family signaling cascades	R-HSA-5683057	5.144284e-01	0.289
Interferon Signaling	R-HSA-913531	2.817271e-01	0.550
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.698460e-01	0.770
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.084329e-01	0.511
Protein-protein interactions at synapses	R-HSA-6794362	3.245666e-01	0.489
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	4.368170e-01	0.360
SLC-mediated transport of neurotransmitters	R-HSA-442660	4.466041e-01	0.350
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.881997e-01	0.725
Interleukin-15 signaling	R-HSA-8983432	4.195026e-01	0.377
Negative regulation of MAPK pathway	R-HSA-5675221	4.466041e-01	0.350
Signaling by TGFBR3	R-HSA-9839373	2.139209e-01	0.670
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.520619e-01	0.598
Signaling by NTRKs	R-HSA-166520	2.388890e-01	0.622
Oligomerization of connexins into connexons	R-HSA-190704	2.356050e-01	0.628
Intracellular oxygen transport	R-HSA-8981607	3.609753e-01	0.443
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.609753e-01	0.443
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.744085e-01	0.758
NADE modulates death signalling	R-HSA-205025	4.157296e-01	0.381
Inositol transporters	R-HSA-429593	4.657952e-01	0.332
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.730032e-01	0.564
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.115735e-01	0.291
Mitotic G2-G2/M phases	R-HSA-453274	1.752947e-01	0.756
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	4.790061e-01	0.320
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.080679e-01	0.389
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.181086e-01	0.286
Signaling by VEGF	R-HSA-194138	2.779267e-01	0.556
NGF-stimulated transcription	R-HSA-9031628	3.866261e-01	0.413
Netrin-1 signaling	R-HSA-373752	4.975233e-01	0.303
Interleukin-2 family signaling	R-HSA-451927	4.119391e-01	0.385
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	2.439062e-01	0.613
G2/M Transition	R-HSA-69275	2.974675e-01	0.527
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.249053e-01	0.648
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.866261e-01	0.413
Signal regulatory protein family interactions	R-HSA-391160	4.790061e-01	0.320
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.229732e-01	0.491
PECAM1 interactions	R-HSA-210990	3.567209e-01	0.448
Tie2 Signaling	R-HSA-210993	3.394667e-01	0.469
TBC/RABGAPs	R-HSA-8854214	4.807291e-01	0.318
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.187167e-01	0.285
Signaling by ROBO receptors	R-HSA-376176	3.455052e-01	0.462
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.686060e-01	0.571
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.431057e-01	0.614
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.394667e-01	0.469
Transcriptional regulation by RUNX2	R-HSA-8878166	4.136942e-01	0.383
Syndecan interactions	R-HSA-3000170	4.809289e-01	0.318
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.493023e-01	0.347
Diseases of DNA repair	R-HSA-9675135	5.304598e-01	0.275
Chaperonin-mediated protein folding	R-HSA-390466	3.594546e-01	0.444
Cytokine Signaling in Immune system	R-HSA-1280215	3.936842e-01	0.405
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.258542e-01	0.646
The NLRP1 inflammasome	R-HSA-844455	3.609753e-01	0.443
Dopamine receptors	R-HSA-390651	4.157296e-01	0.381
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.657952e-01	0.332
PKR-mediated signaling	R-HSA-9833482	1.718506e-01	0.765
CLEC7A/inflammasome pathway	R-HSA-5660668	5.115735e-01	0.291
PI5P Regulates TP53 Acetylation	R-HSA-6811555	4.497103e-01	0.347
Downstream signal transduction	R-HSA-186763	4.226766e-01	0.374
Negative regulation of FLT3	R-HSA-9706369	5.346180e-01	0.272
Regulation of TNFR1 signaling	R-HSA-5357905	3.551740e-01	0.450
TNF signaling	R-HSA-75893	3.505094e-01	0.455
Signaling by Interleukins	R-HSA-449147	4.047166e-01	0.393
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.426997e-01	0.465
Zygotic genome activation (ZGA)	R-HSA-9819196	4.115116e-01	0.386
Activation of ATR in response to replication stress	R-HSA-176187	2.730032e-01	0.564
Maturation of nucleoprotein	R-HSA-9683610	4.497103e-01	0.347
Host Interactions of HIV factors	R-HSA-162909	1.817152e-01	0.741
Potential therapeutics for SARS	R-HSA-9679191	5.394221e-01	0.268
Regulation of CDH11 gene transcription	R-HSA-9762293	2.916641e-01	0.535
Signaling by ALK	R-HSA-201556	1.231670e-01	0.910
L1CAM interactions	R-HSA-373760	2.806677e-01	0.552
Transcriptional Regulation by MECP2	R-HSA-8986944	5.387782e-01	0.269
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.536664e-01	0.813
Glycolysis	R-HSA-70171	1.304343e-01	0.885
Josephin domain DUBs	R-HSA-5689877	3.243957e-01	0.489
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.669274e-01	0.574
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.115735e-01	0.291
Signaling by Leptin	R-HSA-2586552	1.127575e-01	0.948
ChREBP activates metabolic gene expression	R-HSA-163765	3.567209e-01	0.448
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.226473e-01	0.491
Gene Silencing by RNA	R-HSA-211000	2.738171e-01	0.563
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.115735e-01	0.291
OAS antiviral response	R-HSA-8983711	4.195026e-01	0.377
SARS-CoV-2 Infection	R-HSA-9694516	2.656608e-01	0.576
IRE1alpha activates chaperones	R-HSA-381070	1.267943e-01	0.897
SARS-CoV Infections	R-HSA-9679506	1.987082e-01	0.702
Butyrophilin (BTN) family interactions	R-HSA-8851680	2.916641e-01	0.535
Glucose metabolism	R-HSA-70326	2.898630e-01	0.538
SARS-CoV-1 Infection	R-HSA-9678108	2.937677e-01	0.532
Unfolded Protein Response (UPR)	R-HSA-381119	4.263216e-01	0.370
Interleukin-7 signaling	R-HSA-1266695	5.249863e-01	0.280
Growth hormone receptor signaling	R-HSA-982772	4.809289e-01	0.318
Signaling by LTK in cancer	R-HSA-9842640	5.534313e-01	0.257
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	R-HSA-210746	5.534313e-01	0.257
Erythropoietin activates STAT5	R-HSA-9027283	5.534313e-01	0.257
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.534313e-01	0.257
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.534313e-01	0.257
MET Receptor Activation	R-HSA-6806942	5.534313e-01	0.257
CREB phosphorylation	R-HSA-199920	5.534313e-01	0.257
Nef and signal transduction	R-HSA-164944	5.534313e-01	0.257
HDL clearance	R-HSA-8964011	5.534313e-01	0.257
TRAF6 mediated IRF7 activation	R-HSA-933541	5.550027e-01	0.256
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.550027e-01	0.256
Degradation of DVL	R-HSA-4641258	5.550027e-01	0.256
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.557063e-01	0.255
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.573521e-01	0.254
Organelle biogenesis and maintenance	R-HSA-1852241	5.575440e-01	0.254
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.608542e-01	0.251
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.608542e-01	0.251
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.608542e-01	0.251
Acetylcholine regulates insulin secretion	R-HSA-399997	5.608542e-01	0.251
Disorders of Developmental Biology	R-HSA-9675151	5.608542e-01	0.251
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	5.608542e-01	0.251
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.616945e-01	0.250
Regulation of mitotic cell cycle	R-HSA-453276	5.616945e-01	0.250
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.623947e-01	0.250
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.635501e-01	0.249
SHC-mediated cascade:FGFR2	R-HSA-5654699	5.668987e-01	0.246
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.668987e-01	0.246
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.668987e-01	0.246
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.668987e-01	0.246
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.668987e-01	0.246
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.668987e-01	0.246
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.668987e-01	0.246
MHC class II antigen presentation	R-HSA-2132295	5.693076e-01	0.245
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.725869e-01	0.242
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	5.725869e-01	0.242
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	5.748326e-01	0.240
DNA Damage Bypass	R-HSA-73893	5.779437e-01	0.238
Response of endothelial cells to shear stress	R-HSA-9860931	5.793281e-01	0.237
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.802807e-01	0.236
PLC beta mediated events	R-HSA-112043	5.829970e-01	0.234
PPARA activates gene expression	R-HSA-1989781	5.845895e-01	0.233
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.860139e-01	0.232
Regulation of NPAS4 gene expression	R-HSA-9768759	5.860139e-01	0.232
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	5.860139e-01	0.232
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	5.860139e-01	0.232
HIV elongation arrest and recovery	R-HSA-167287	5.869823e-01	0.231
Pausing and recovery of HIV elongation	R-HSA-167290	5.869823e-01	0.231
Inflammasomes	R-HSA-622312	5.869823e-01	0.231
Stabilization of p53	R-HSA-69541	5.897734e-01	0.229
MET activates PI3K/AKT signaling	R-HSA-8851907	5.917042e-01	0.228
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	5.917042e-01	0.228
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	5.917042e-01	0.228
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	5.917042e-01	0.228
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	5.917042e-01	0.228
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	5.917042e-01	0.228
Disinhibition of SNARE formation	R-HSA-114516	5.917042e-01	0.228
PTK6 Expression	R-HSA-8849473	5.917042e-01	0.228
TRIF-mediated programmed cell death	R-HSA-2562578	5.917042e-01	0.228
Reuptake of GABA	R-HSA-888593	5.917042e-01	0.228
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.917042e-01	0.228
VLDL clearance	R-HSA-8964046	5.917042e-01	0.228
Regulation of PTEN localization	R-HSA-8948747	5.917042e-01	0.228
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	5.917042e-01	0.228
CHL1 interactions	R-HSA-447041	5.917042e-01	0.228
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	5.917042e-01	0.228
Meiosis	R-HSA-1500620	5.923269e-01	0.227
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.968357e-01	0.224
Cilium Assembly	R-HSA-5617833	5.977325e-01	0.223
Signaling by FGFR in disease	R-HSA-1226099	6.005300e-01	0.221
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.008130e-01	0.221
Influenza Infection	R-HSA-168255	6.017656e-01	0.221
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	6.021462e-01	0.220
Late endosomal microautophagy	R-HSA-9615710	6.064584e-01	0.217
DARPP-32 events	R-HSA-180024	6.064584e-01	0.217
Termination of translesion DNA synthesis	R-HSA-5656169	6.064584e-01	0.217
Regulation of gene expression in beta cells	R-HSA-210745	6.064584e-01	0.217
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.064584e-01	0.217
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.065469e-01	0.217
Generation of second messenger molecules	R-HSA-202433	6.065469e-01	0.217
Negative regulation of NOTCH4 signaling	R-HSA-9604323	6.065469e-01	0.217
RNA Polymerase III Transcription Termination	R-HSA-73980	6.100889e-01	0.215
GAB1 signalosome	R-HSA-180292	6.100889e-01	0.215
Chaperone Mediated Autophagy	R-HSA-9613829	6.100889e-01	0.215
Synaptic adhesion-like molecules	R-HSA-8849932	6.100889e-01	0.215
Mismatch Repair	R-HSA-5358508	6.100889e-01	0.215
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.130719e-01	0.212
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.135945e-01	0.212
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.158991e-01	0.210
COPI-mediated anterograde transport	R-HSA-6807878	6.188134e-01	0.208
Neurexins and neuroligins	R-HSA-6794361	6.227524e-01	0.206
Uptake and actions of bacterial toxins	R-HSA-5339562	6.227524e-01	0.206
FLT3 Signaling	R-HSA-9607240	6.228943e-01	0.206
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.237579e-01	0.205
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.253135e-01	0.204
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	6.253135e-01	0.204
Interleukin-37 signaling	R-HSA-9008059	6.253135e-01	0.204
RSK activation	R-HSA-444257	6.266991e-01	0.203
Regulation by c-FLIP	R-HSA-3371378	6.266991e-01	0.203
Dimerization of procaspase-8	R-HSA-69416	6.266991e-01	0.203
phospho-PLA2 pathway	R-HSA-111995	6.266991e-01	0.203
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.266991e-01	0.203
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.266991e-01	0.203
Myoclonic epilepsy of Lafora	R-HSA-3785653	6.266991e-01	0.203
MET receptor recycling	R-HSA-8875656	6.266991e-01	0.203
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.266991e-01	0.203
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.266991e-01	0.203
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.266991e-01	0.203
Downregulation of ERBB4 signaling	R-HSA-1253288	6.266991e-01	0.203
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.266991e-01	0.203
TGFBR3 PTM regulation	R-HSA-9839383	6.266991e-01	0.203
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.266991e-01	0.203
Sodium/Proton exchangers	R-HSA-425986	6.266991e-01	0.203
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.320213e-01	0.199
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.320213e-01	0.199
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.330804e-01	0.199
Specification of the neural plate border	R-HSA-9834899	6.330804e-01	0.199
Regulation of signaling by CBL	R-HSA-912631	6.330804e-01	0.199
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.330804e-01	0.199
The NLRP3 inflammasome	R-HSA-844456	6.330804e-01	0.199
Maturation of nucleoprotein	R-HSA-9694631	6.330804e-01	0.199
TCF dependent signaling in response to WNT	R-HSA-201681	6.339159e-01	0.198
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	6.370397e-01	0.196
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.370397e-01	0.196
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.388053e-01	0.195
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	6.388053e-01	0.195
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.421329e-01	0.192
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	6.435385e-01	0.191
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	6.441034e-01	0.191
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.441034e-01	0.191
RNA Polymerase I Transcription	R-HSA-73864	6.493816e-01	0.188
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.520917e-01	0.186
MyD88-independent TLR4 cascade	R-HSA-166166	6.520917e-01	0.186
Negative regulation of MET activity	R-HSA-6807004	6.549971e-01	0.184
Protein hydroxylation	R-HSA-9629569	6.549971e-01	0.184
Signal transduction by L1	R-HSA-445144	6.549971e-01	0.184
Lipophagy	R-HSA-9613354	6.586964e-01	0.181
Interleukin-21 signaling	R-HSA-9020958	6.586964e-01	0.181
CASP8 activity is inhibited	R-HSA-5218900	6.586964e-01	0.181
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.586964e-01	0.181
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.586964e-01	0.181
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.586964e-01	0.181
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.586964e-01	0.181
p75NTR regulates axonogenesis	R-HSA-193697	6.586964e-01	0.181
Regulation of signaling by NODAL	R-HSA-1433617	6.586964e-01	0.181
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.586964e-01	0.181
Interleukin-1 processing	R-HSA-448706	6.586964e-01	0.181
Cellular response to mitochondrial stress	R-HSA-9840373	6.586964e-01	0.181
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.611277e-01	0.180
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.621338e-01	0.179
G-protein mediated events	R-HSA-112040	6.621338e-01	0.179
Signaling by SCF-KIT	R-HSA-1433557	6.692875e-01	0.174
Signaling by FGFR4	R-HSA-5654743	6.692875e-01	0.174
Interleukin-1 signaling	R-HSA-9020702	6.712781e-01	0.173
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.721516e-01	0.173
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.721516e-01	0.173
Signaling by FGFR2	R-HSA-5654738	6.724326e-01	0.172
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.743655e-01	0.171
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.758544e-01	0.170
TNFR1-induced proapoptotic signaling	R-HSA-5357786	6.758544e-01	0.170
Signalling to RAS	R-HSA-167044	6.758544e-01	0.170
ERK/MAPK targets	R-HSA-198753	6.758544e-01	0.170
Basigin interactions	R-HSA-210991	6.758544e-01	0.170
Ribosomal scanning and start codon recognition	R-HSA-72702	6.778443e-01	0.169
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.778443e-01	0.169
FGFR1 mutant receptor activation	R-HSA-1839124	6.780792e-01	0.169
Regulation of necroptotic cell death	R-HSA-5675482	6.780792e-01	0.169
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.810162e-01	0.167
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.879529e-01	0.162
Binding and entry of HIV virion	R-HSA-173107	6.879529e-01	0.162
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	6.879529e-01	0.162
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	6.879529e-01	0.162
Pexophagy	R-HSA-9664873	6.879529e-01	0.162
Receptor Mediated Mitophagy	R-HSA-8934903	6.879529e-01	0.162
Defective factor IX causes hemophilia B	R-HSA-9668250	6.879529e-01	0.162
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	6.879529e-01	0.162
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.943940e-01	0.158
Miscellaneous transport and binding events	R-HSA-5223345	6.943940e-01	0.158
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.956729e-01	0.158
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.956729e-01	0.158
FRS-mediated FGFR3 signaling	R-HSA-5654706	6.956729e-01	0.158
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.956729e-01	0.158
Asymmetric localization of PCP proteins	R-HSA-4608870	6.979524e-01	0.156
Signaling by FGFR3	R-HSA-5654741	6.979524e-01	0.156
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.979625e-01	0.156
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	7.032849e-01	0.153
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.074834e-01	0.150
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.074834e-01	0.150
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.074834e-01	0.150
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.084524e-01	0.150
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.100757e-01	0.149
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.100757e-01	0.149
Mitophagy	R-HSA-5205647	7.100757e-01	0.149
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.100757e-01	0.149
NOD1/2 Signaling Pathway	R-HSA-168638	7.100757e-01	0.149
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.144773e-01	0.146
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.144773e-01	0.146
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.144773e-01	0.146
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.144773e-01	0.146
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.144773e-01	0.146
Signaling by KIT in disease	R-HSA-9669938	7.144773e-01	0.146
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.147031e-01	0.146
Signaling by APC mutants	R-HSA-4839744	7.147031e-01	0.146
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	7.147031e-01	0.146
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	7.147031e-01	0.146
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	7.147031e-01	0.146
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.147031e-01	0.146
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.147031e-01	0.146
vRNA Synthesis	R-HSA-192814	7.147031e-01	0.146
Synthesis of PI	R-HSA-1483226	7.147031e-01	0.146
RHOBTB3 ATPase cycle	R-HSA-9706019	7.147031e-01	0.146
Bicarbonate transporters	R-HSA-425381	7.147031e-01	0.146
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	7.147031e-01	0.146
Suppression of apoptosis	R-HSA-9635465	7.147031e-01	0.146
Interleukin-2 signaling	R-HSA-9020558	7.147031e-01	0.146
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.223209e-01	0.141
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.247884e-01	0.140
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.247884e-01	0.140
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.247884e-01	0.140
Regulation of Apoptosis	R-HSA-169911	7.251304e-01	0.140
MAPK6/MAPK4 signaling	R-HSA-5687128	7.257830e-01	0.139
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.322958e-01	0.135
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.322958e-01	0.135
Formation of the ureteric bud	R-HSA-9830674	7.322958e-01	0.135
Cellular response to chemical stress	R-HSA-9711123	7.373796e-01	0.132
Intraflagellar transport	R-HSA-5620924	7.375237e-01	0.132
GPER1 signaling	R-HSA-9634597	7.375237e-01	0.132
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.387587e-01	0.131
Formation of paraxial mesoderm	R-HSA-9793380	7.387587e-01	0.131
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.391615e-01	0.131
Condensation of Prometaphase Chromosomes	R-HSA-2514853	7.391615e-01	0.131
Signaling by GSK3beta mutants	R-HSA-5339716	7.391615e-01	0.131
Endosomal/Vacuolar pathway	R-HSA-1236977	7.391615e-01	0.131
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.391615e-01	0.131
Plasmalogen biosynthesis	R-HSA-75896	7.391615e-01	0.131
Signaling by AXIN mutants	R-HSA-4839735	7.391615e-01	0.131
Signaling by AMER1 mutants	R-HSA-4839748	7.391615e-01	0.131
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.391615e-01	0.131
HSF1 activation	R-HSA-3371511	7.395664e-01	0.131
PRC2 methylates histones and DNA	R-HSA-212300	7.395664e-01	0.131
FLT3 signaling in disease	R-HSA-9682385	7.395664e-01	0.131
Signaling by ERBB4	R-HSA-1236394	7.416272e-01	0.130
Antigen processing-Cross presentation	R-HSA-1236975	7.456373e-01	0.127
Complex III assembly	R-HSA-9865881	7.491592e-01	0.125
Signaling by PDGF	R-HSA-186797	7.498675e-01	0.125
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.518036e-01	0.124
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	7.615245e-01	0.118
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	7.615245e-01	0.118
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	7.615245e-01	0.118
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	7.615245e-01	0.118
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	7.615245e-01	0.118
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	7.615245e-01	0.118
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	7.615245e-01	0.118
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.615245e-01	0.118
Diseases associated with surfactant metabolism	R-HSA-5687613	7.615245e-01	0.118
Polymerase switching	R-HSA-69091	7.615245e-01	0.118
VLDLR internalisation and degradation	R-HSA-8866427	7.615245e-01	0.118
Leading Strand Synthesis	R-HSA-69109	7.615245e-01	0.118
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.615245e-01	0.118
IRAK1 recruits IKK complex	R-HSA-937039	7.615245e-01	0.118
Regulation of RAS by GAPs	R-HSA-5658442	7.616468e-01	0.118
Signaling by FGFR2 in disease	R-HSA-5655253	7.616468e-01	0.118
RNA Polymerase I Promoter Clearance	R-HSA-73854	7.616852e-01	0.118
TCR signaling	R-HSA-202403	7.622878e-01	0.118
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.651003e-01	0.116
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.651003e-01	0.116
Laminin interactions	R-HSA-3000157	7.651003e-01	0.116
RIPK1-mediated regulated necrosis	R-HSA-5213460	7.666238e-01	0.115
Platelet activation, signaling and aggregation	R-HSA-76002	7.701343e-01	0.113
SLC transporter disorders	R-HSA-5619102	7.706131e-01	0.113
Insulin receptor signalling cascade	R-HSA-74751	7.710229e-01	0.113
Nonsense-Mediated Decay (NMD)	R-HSA-927802	7.781550e-01	0.109
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	7.781550e-01	0.109
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.792698e-01	0.108
Plasma lipoprotein clearance	R-HSA-8964043	7.792698e-01	0.108
MET activates PTK2 signaling	R-HSA-8874081	7.801532e-01	0.108
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.801532e-01	0.108
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.801532e-01	0.108
PCP/CE pathway	R-HSA-4086400	7.805711e-01	0.108
Cellular response to hypoxia	R-HSA-1234174	7.810761e-01	0.107
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	7.819714e-01	0.107
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.819714e-01	0.107
Membrane binding and targetting of GAG proteins	R-HSA-174490	7.819714e-01	0.107
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	7.819714e-01	0.107
Processing of SMDT1	R-HSA-8949664	7.819714e-01	0.107
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	7.819714e-01	0.107
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	7.819714e-01	0.107
Platelet Adhesion to exposed collagen	R-HSA-75892	7.819714e-01	0.107
Replication of the SARS-CoV-1 genome	R-HSA-9682706	7.819714e-01	0.107
Formation of RNA Pol II elongation complex	R-HSA-112382	7.840099e-01	0.106
HCMV Late Events	R-HSA-9610379	7.856575e-01	0.105
Sensory processing of sound	R-HSA-9659379	7.895802e-01	0.103
PI Metabolism	R-HSA-1483255	7.912603e-01	0.102
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.913456e-01	0.102
Inhibition of DNA recombination at telomere	R-HSA-9670095	7.913456e-01	0.102
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.913456e-01	0.102
HIV Transcription Elongation	R-HSA-167169	7.913456e-01	0.102
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.913456e-01	0.102
Diseases of Immune System	R-HSA-5260271	7.913456e-01	0.102
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.913456e-01	0.102
RNA Polymerase I Transcription Termination	R-HSA-73863	7.943530e-01	0.100
Interaction between L1 and Ankyrins	R-HSA-445095	7.943530e-01	0.100
Signaling by FGFR3 in disease	R-HSA-5655332	7.943530e-01	0.100
RNA Polymerase II Transcription Elongation	R-HSA-75955	7.945487e-01	0.100
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.983038e-01	0.098
Removal of the Flap Intermediate	R-HSA-69166	8.006663e-01	0.097
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.006663e-01	0.097
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.006663e-01	0.097
CRMPs in Sema3A signaling	R-HSA-399956	8.006663e-01	0.097
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.006663e-01	0.097
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.006663e-01	0.097
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.006663e-01	0.097
Hydrolysis of LPC	R-HSA-1483115	8.006663e-01	0.097
Retrograde neurotrophin signalling	R-HSA-177504	8.006663e-01	0.097
Prolactin receptor signaling	R-HSA-1170546	8.006663e-01	0.097
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.006663e-01	0.097
HDL assembly	R-HSA-8963896	8.006663e-01	0.097
Acyl chain remodeling of CL	R-HSA-1482798	8.006663e-01	0.097
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.006663e-01	0.097
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.028662e-01	0.095
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.028662e-01	0.095
Opioid Signalling	R-HSA-111885	8.064092e-01	0.093
Regulation of PD-L1(CD274) expression	R-HSA-9909648	8.074486e-01	0.093
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	8.077353e-01	0.093
Formation of the Early Elongation Complex	R-HSA-113418	8.077353e-01	0.093
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.077353e-01	0.093
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.077353e-01	0.093
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.077353e-01	0.093
Ub-specific processing proteases	R-HSA-5689880	8.131479e-01	0.090
RSV-host interactions	R-HSA-9833110	8.136643e-01	0.090
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.138474e-01	0.089
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.138474e-01	0.089
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.138474e-01	0.089
HIV Transcription Initiation	R-HSA-167161	8.138474e-01	0.089
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.138474e-01	0.089
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.177592e-01	0.087
Beta-catenin phosphorylation cascade	R-HSA-196299	8.177592e-01	0.087
RNA Polymerase III Chain Elongation	R-HSA-73780	8.177592e-01	0.087
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.177592e-01	0.087
Processive synthesis on the lagging strand	R-HSA-69183	8.177592e-01	0.087
Sema3A PAK dependent Axon repulsion	R-HSA-399954	8.177592e-01	0.087
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.177592e-01	0.087
Signaling by Activin	R-HSA-1502540	8.177592e-01	0.087
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.177592e-01	0.087
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.177592e-01	0.087
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.177592e-01	0.087
IRF3-mediated induction of type I IFN	R-HSA-3270619	8.177592e-01	0.087
Protein methylation	R-HSA-8876725	8.177592e-01	0.087
mRNA Capping	R-HSA-72086	8.203359e-01	0.086
Cap-dependent Translation Initiation	R-HSA-72737	8.211229e-01	0.086
Eukaryotic Translation Initiation	R-HSA-72613	8.211229e-01	0.086
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.236939e-01	0.084
Signaling by FGFR1	R-HSA-5654736	8.236939e-01	0.084
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.262808e-01	0.083
Interleukin-1 family signaling	R-HSA-446652	8.310059e-01	0.080
Downregulation of ERBB2 signaling	R-HSA-8863795	8.321903e-01	0.080
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.321903e-01	0.080
Regulation of CDH1 Function	R-HSA-9764561	8.326161e-01	0.080
IRS-mediated signalling	R-HSA-112399	8.326161e-01	0.080
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	8.333874e-01	0.079
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	8.333874e-01	0.079
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.333874e-01	0.079
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.333874e-01	0.079
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.333874e-01	0.079
Differentiation of T cells	R-HSA-9945266	8.333874e-01	0.079
Activation of SMO	R-HSA-5635838	8.333874e-01	0.079
RNA Polymerase II Promoter Escape	R-HSA-73776	8.342571e-01	0.079
NoRC negatively regulates rRNA expression	R-HSA-427413	8.343496e-01	0.079
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	8.406125e-01	0.075
Dual incision in TC-NER	R-HSA-6782135	8.411586e-01	0.075
CLEC7A (Dectin-1) signaling	R-HSA-5607764	8.420846e-01	0.075
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.421094e-01	0.075
Trafficking of AMPA receptors	R-HSA-399719	8.433339e-01	0.074
Budding and maturation of HIV virion	R-HSA-162588	8.433339e-01	0.074
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.433339e-01	0.074
Molecules associated with elastic fibres	R-HSA-2129379	8.433339e-01	0.074
Amine ligand-binding receptors	R-HSA-375280	8.437194e-01	0.074
Surfactant metabolism	R-HSA-5683826	8.437194e-01	0.074
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.448724e-01	0.073
G beta:gamma signalling through CDC42	R-HSA-8964616	8.476761e-01	0.072
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.476761e-01	0.072
Synthesis of PG	R-HSA-1483148	8.476761e-01	0.072
Coenzyme A biosynthesis	R-HSA-196783	8.476761e-01	0.072
tRNA modification in the mitochondrion	R-HSA-6787450	8.476761e-01	0.072
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.476761e-01	0.072
Amino acid transport across the plasma membrane	R-HSA-352230	8.493316e-01	0.071
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.527095e-01	0.069
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.527095e-01	0.069
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.527095e-01	0.069
Signaling by WNT in cancer	R-HSA-4791275	8.538013e-01	0.069
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.538013e-01	0.069
Signaling by FGFR	R-HSA-190236	8.549229e-01	0.068
RNA Polymerase II Pre-transcription Events	R-HSA-674695	8.567307e-01	0.067
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	8.568470e-01	0.067
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.607403e-01	0.065
PI3K events in ERBB2 signaling	R-HSA-1963642	8.607403e-01	0.065
Glycogen storage diseases	R-HSA-3229121	8.607403e-01	0.065
Elevation of cytosolic Ca2+ levels	R-HSA-139853	8.607403e-01	0.065
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.607403e-01	0.065
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.607403e-01	0.065
Condensation of Prophase Chromosomes	R-HSA-2299718	8.612448e-01	0.065
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.620745e-01	0.064
tRNA processing	R-HSA-72306	8.626342e-01	0.064
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.636069e-01	0.064
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.636265e-01	0.064
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.636265e-01	0.064
G-protein beta:gamma signalling	R-HSA-397795	8.636265e-01	0.064
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.636265e-01	0.064
Cardiogenesis	R-HSA-9733709	8.636265e-01	0.064
IRS-related events triggered by IGF1R	R-HSA-2428928	8.646121e-01	0.063
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.693426e-01	0.061
ER-Phagosome pathway	R-HSA-1236974	8.707688e-01	0.060
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.726847e-01	0.059
G beta:gamma signalling through PLC beta	R-HSA-418217	8.726847e-01	0.059
Ephrin signaling	R-HSA-3928664	8.726847e-01	0.059
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	8.726847e-01	0.059
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.726847e-01	0.059
PKA activation	R-HSA-163615	8.726847e-01	0.059
PKA activation in glucagon signalling	R-HSA-164378	8.726847e-01	0.059
Presynaptic function of Kainate receptors	R-HSA-500657	8.726847e-01	0.059
Polo-like kinase mediated events	R-HSA-156711	8.726847e-01	0.059
Platelet sensitization by LDL	R-HSA-432142	8.726847e-01	0.059
Vpu mediated degradation of CD4	R-HSA-180534	8.728426e-01	0.059
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.728426e-01	0.059
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.814745e-01	0.055
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	8.814819e-01	0.055
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.814819e-01	0.055
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	8.814819e-01	0.055
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.814819e-01	0.055
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.836053e-01	0.054
PI-3K cascade:FGFR3	R-HSA-5654710	8.836053e-01	0.054
Germ layer formation at gastrulation	R-HSA-9754189	8.836053e-01	0.054
Pyrimidine biosynthesis	R-HSA-500753	8.836053e-01	0.054
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.836053e-01	0.054
Other interleukin signaling	R-HSA-449836	8.836053e-01	0.054
Diseases of hemostasis	R-HSA-9671793	8.836053e-01	0.054
STING mediated induction of host immune responses	R-HSA-1834941	8.836053e-01	0.054
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	8.836053e-01	0.054
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.836053e-01	0.054
Degradation of CDH1	R-HSA-9766229	8.842943e-01	0.053
Platelet degranulation	R-HSA-114608	8.875836e-01	0.052
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.895754e-01	0.051
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.895754e-01	0.051
PERK regulates gene expression	R-HSA-381042	8.895754e-01	0.051
PI3K Cascade	R-HSA-109704	8.911821e-01	0.050
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.935897e-01	0.049
PI-3K cascade:FGFR4	R-HSA-5654720	8.935897e-01	0.049
Glycogen synthesis	R-HSA-3322077	8.935897e-01	0.049
Co-inhibition by CTLA4	R-HSA-389513	8.935897e-01	0.049
Wax and plasmalogen biosynthesis	R-HSA-8848584	8.935897e-01	0.049
Acyl chain remodelling of PI	R-HSA-1482922	8.935897e-01	0.049
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.935897e-01	0.049
Nephrin family interactions	R-HSA-373753	8.935897e-01	0.049
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.971531e-01	0.047
Glycosphingolipid transport	R-HSA-9845576	8.971531e-01	0.047
GPVI-mediated activation cascade	R-HSA-114604	8.971531e-01	0.047
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.971531e-01	0.047
Lysosome Vesicle Biogenesis	R-HSA-432720	8.971531e-01	0.047
FGFR2 mutant receptor activation	R-HSA-1839126	8.971531e-01	0.047
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.977000e-01	0.047
SLC-mediated transport of amino acids	R-HSA-9958863	9.027131e-01	0.044
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.027182e-01	0.044
Lagging Strand Synthesis	R-HSA-69186	9.027182e-01	0.044
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.027182e-01	0.044
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.027182e-01	0.044
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.027182e-01	0.044
Early Phase of HIV Life Cycle	R-HSA-162594	9.027182e-01	0.044
Acyl chain remodelling of PG	R-HSA-1482925	9.027182e-01	0.044
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.027743e-01	0.044
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.038642e-01	0.044
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.038642e-01	0.044
Degradation of AXIN	R-HSA-4641257	9.042441e-01	0.044
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.042441e-01	0.044
Transcription of the HIV genome	R-HSA-167172	9.080487e-01	0.042
Regulated Necrosis	R-HSA-5218859	9.080487e-01	0.042
Elastic fibre formation	R-HSA-1566948	9.108759e-01	0.041
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.110641e-01	0.040
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.110641e-01	0.040
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.110641e-01	0.040
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.110641e-01	0.040
Molybdenum cofactor biosynthesis	R-HSA-947581	9.110641e-01	0.040
Assembly Of The HIV Virion	R-HSA-175474	9.110641e-01	0.040
Serine metabolism	R-HSA-977347	9.110641e-01	0.040
Glutathione synthesis and recycling	R-HSA-174403	9.110641e-01	0.040
Mitochondrial calcium ion transport	R-HSA-8949215	9.110641e-01	0.040
Ribavirin ADME	R-HSA-9755088	9.110641e-01	0.040
Signaling by WNT	R-HSA-195721	9.111130e-01	0.040
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.111346e-01	0.040
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.131228e-01	0.039
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.151947e-01	0.038
Viral Infection Pathways	R-HSA-9824446	9.154375e-01	0.038
Pentose phosphate pathway	R-HSA-71336	9.170751e-01	0.038
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.170751e-01	0.038
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.170751e-01	0.038
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.170751e-01	0.038
PI-3K cascade:FGFR1	R-HSA-5654689	9.186945e-01	0.037
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.186945e-01	0.037
LDL clearance	R-HSA-8964038	9.186945e-01	0.037
Telomere Maintenance	R-HSA-157579	9.201054e-01	0.036
G alpha (z) signalling events	R-HSA-418597	9.203915e-01	0.036
Nuclear signaling by ERBB4	R-HSA-1251985	9.228672e-01	0.035
ER to Golgi Anterograde Transport	R-HSA-199977	9.235865e-01	0.035
Co-inhibition by PD-1	R-HSA-389948	9.239823e-01	0.034
Ion homeostasis	R-HSA-5578775	9.252957e-01	0.034
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.252957e-01	0.034
Regulation of PTEN mRNA translation	R-HSA-8943723	9.256706e-01	0.034
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.256706e-01	0.034
Free fatty acids regulate insulin secretion	R-HSA-400451	9.256706e-01	0.034
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.256706e-01	0.034
Organic anion transport by SLCO transporters	R-HSA-879518	9.256706e-01	0.034
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.256706e-01	0.034
FCERI mediated MAPK activation	R-HSA-2871796	9.263311e-01	0.033
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.268785e-01	0.033
Hh mutants are degraded by ERAD	R-HSA-5362768	9.282763e-01	0.032
VEGFR2 mediated vascular permeability	R-HSA-5218920	9.282763e-01	0.032
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.282763e-01	0.032
Beta-catenin independent WNT signaling	R-HSA-3858494	9.291756e-01	0.032
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.318859e-01	0.031
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.320485e-01	0.031
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.320485e-01	0.031
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.320485e-01	0.031
Mitochondrial RNA degradation	R-HSA-9836573	9.320485e-01	0.031
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.320485e-01	0.031
Plasma lipoprotein assembly	R-HSA-8963898	9.320485e-01	0.031
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.333255e-01	0.030
Degradation of CRY and PER proteins	R-HSA-9932298	9.333255e-01	0.030
Translation of Structural Proteins	R-HSA-9683701	9.333255e-01	0.030
Toll-like Receptor Cascades	R-HSA-168898	9.354459e-01	0.029
PI-3K cascade:FGFR2	R-HSA-5654695	9.378795e-01	0.028
Long-term potentiation	R-HSA-9620244	9.378795e-01	0.028
Tight junction interactions	R-HSA-420029	9.378795e-01	0.028
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.378795e-01	0.028
Hyaluronan degradation	R-HSA-2160916	9.378795e-01	0.028
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.378795e-01	0.028
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.378795e-01	0.028
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	9.380368e-01	0.028
Cleavage of the damaged pyrimidine	R-HSA-110329	9.380368e-01	0.028
Depyrimidination	R-HSA-73928	9.380368e-01	0.028
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.380387e-01	0.028
Extension of Telomeres	R-HSA-180786	9.383915e-01	0.028
Hemostasis	R-HSA-109582	9.391304e-01	0.027
Neurotransmitter release cycle	R-HSA-112310	9.408621e-01	0.026
Downstream TCR signaling	R-HSA-202424	9.408621e-01	0.026
Base Excision Repair	R-HSA-73884	9.408621e-01	0.026
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.422619e-01	0.026
Defective pyroptosis	R-HSA-9710421	9.424308e-01	0.026
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.424308e-01	0.026
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.432105e-01	0.025
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.432105e-01	0.025
Urea cycle	R-HSA-70635	9.432105e-01	0.025
Sphingolipid catabolism	R-HSA-9845614	9.432105e-01	0.025
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.432105e-01	0.025
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.432105e-01	0.025
Proteasome assembly	R-HSA-9907900	9.465274e-01	0.024
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.468327e-01	0.024
Activation of HOX genes during differentiation	R-HSA-5619507	9.468327e-01	0.024
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.470366e-01	0.024
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.480843e-01	0.023
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.480843e-01	0.023
Cristae formation	R-HSA-8949613	9.480843e-01	0.023
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.480843e-01	0.023
Insulin processing	R-HSA-264876	9.480843e-01	0.023
Integrin cell surface interactions	R-HSA-216083	9.486538e-01	0.023
NCAM signaling for neurite out-growth	R-HSA-375165	9.493347e-01	0.023
Signaling by Insulin receptor	R-HSA-74752	9.498997e-01	0.022
Fanconi Anemia Pathway	R-HSA-6783310	9.503452e-01	0.022
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.503452e-01	0.022
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.503452e-01	0.022
Somitogenesis	R-HSA-9824272	9.503452e-01	0.022
Telomere Extension By Telomerase	R-HSA-171319	9.525400e-01	0.021
Phase 0 - rapid depolarisation	R-HSA-5576892	9.525400e-01	0.021
Negative regulation of FGFR3 signaling	R-HSA-5654732	9.525400e-01	0.021
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.525400e-01	0.021
Pyroptosis	R-HSA-5620971	9.525400e-01	0.021
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.539018e-01	0.020
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.539018e-01	0.020
Regulation of pyruvate metabolism	R-HSA-9861718	9.539018e-01	0.020
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.539018e-01	0.020
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.539018e-01	0.020
Interferon gamma signaling	R-HSA-877300	9.542562e-01	0.020
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.544725e-01	0.020
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.566136e-01	0.019
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.566136e-01	0.019
DNA methylation	R-HSA-5334118	9.566136e-01	0.019
Platelet calcium homeostasis	R-HSA-418360	9.566136e-01	0.019
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.566136e-01	0.019
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.566136e-01	0.019
Co-stimulation by CD28	R-HSA-389356	9.602976e-01	0.018
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.603378e-01	0.018
Neurotransmitter clearance	R-HSA-112311	9.603378e-01	0.018
Cytoprotection by HMOX1	R-HSA-9707564	9.620687e-01	0.017
Chemokine receptors bind chemokines	R-HSA-380108	9.631672e-01	0.016
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.631672e-01	0.016
Integration of energy metabolism	R-HSA-163685	9.634142e-01	0.016
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.637425e-01	0.016
Cargo concentration in the ER	R-HSA-5694530	9.637425e-01	0.016
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.637425e-01	0.016
Disorders of transmembrane transporters	R-HSA-5619115	9.653689e-01	0.015
Azathioprine ADME	R-HSA-9748787	9.658370e-01	0.015
Meiotic recombination	R-HSA-912446	9.683201e-01	0.014
Cytosolic sulfonation of small molecules	R-HSA-156584	9.683201e-01	0.014
Hedgehog ligand biogenesis	R-HSA-5358346	9.683201e-01	0.014
Developmental Cell Lineages	R-HSA-9734767	9.683431e-01	0.014
Negative regulation of FGFR1 signaling	R-HSA-5654726	9.697006e-01	0.013
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	9.697006e-01	0.013
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.699734e-01	0.013
Parasite infection	R-HSA-9664407	9.699734e-01	0.013
Leishmania phagocytosis	R-HSA-9664417	9.699734e-01	0.013
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.714367e-01	0.013
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.722445e-01	0.012
Acyl chain remodelling of PC	R-HSA-1482788	9.723021e-01	0.012
Glucagon signaling in metabolic regulation	R-HSA-163359	9.723021e-01	0.012
Effects of PIP2 hydrolysis	R-HSA-114508	9.723021e-01	0.012
Regulation of PTEN stability and activity	R-HSA-8948751	9.727748e-01	0.012
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.735118e-01	0.012
Muscle contraction	R-HSA-397014	9.735118e-01	0.012
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.735721e-01	0.012
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.743572e-01	0.011
Negative regulation of FGFR2 signaling	R-HSA-5654727	9.746803e-01	0.011
Hyaluronan metabolism	R-HSA-2142845	9.746803e-01	0.011
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.746803e-01	0.011
Signal amplification	R-HSA-392518	9.746803e-01	0.011
eNOS activation	R-HSA-203615	9.746803e-01	0.011
NPAS4 regulates expression of target genes	R-HSA-9768919	9.746803e-01	0.011
C-type lectin receptors (CLRs)	R-HSA-5621481	9.747006e-01	0.011
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.747690e-01	0.011
Regulation of T cell activation by CD28 family	R-HSA-388841	9.756444e-01	0.011
Ca2+ pathway	R-HSA-4086398	9.757864e-01	0.011
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.762621e-01	0.010
Paracetamol ADME	R-HSA-9753281	9.766216e-01	0.010
Acyl chain remodelling of PE	R-HSA-1482839	9.768544e-01	0.010
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.768544e-01	0.010
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.780421e-01	0.010
Protein ubiquitination	R-HSA-8852135	9.788958e-01	0.009
Synthesis of PA	R-HSA-1483166	9.799400e-01	0.009
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.802000e-01	0.009
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.806590e-01	0.008
Metabolism of folate and pterines	R-HSA-196757	9.806590e-01	0.008
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.809605e-01	0.008
Translation of Structural Proteins	R-HSA-9694635	9.816222e-01	0.008
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.823201e-01	0.008
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.823201e-01	0.008
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.827995e-01	0.008
Cholesterol biosynthesis	R-HSA-191273	9.828559e-01	0.008
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.831557e-01	0.007
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.838386e-01	0.007
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.840101e-01	0.007
Metabolism of polyamines	R-HSA-351202	9.840767e-01	0.007
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.850240e-01	0.007
Glycogen metabolism	R-HSA-8982491	9.852267e-01	0.006
Tryptophan catabolism	R-HSA-71240	9.852267e-01	0.006
Formation of a pool of free 40S subunits	R-HSA-72689	9.852852e-01	0.006
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.852852e-01	0.006
Mitochondrial protein import	R-HSA-1268020	9.863603e-01	0.006
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.864957e-01	0.006
Maturation of spike protein	R-HSA-9694548	9.864957e-01	0.006
Aflatoxin activation and detoxification	R-HSA-5423646	9.864957e-01	0.006
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.873791e-01	0.006
Intra-Golgi traffic	R-HSA-6811438	9.876558e-01	0.005
Heme biosynthesis	R-HSA-189451	9.876558e-01	0.005
Post-translational protein phosphorylation	R-HSA-8957275	9.878980e-01	0.005
Regulation of insulin secretion	R-HSA-422356	9.878980e-01	0.005
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.879247e-01	0.005
Ion transport by P-type ATPases	R-HSA-936837	9.883237e-01	0.005
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.887163e-01	0.005
Response of Mtb to phagocytosis	R-HSA-9637690	9.896857e-01	0.005
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.905719e-01	0.004
Kidney development	R-HSA-9830369	9.907622e-01	0.004
Transmission across Chemical Synapses	R-HSA-112315	9.911492e-01	0.004
Phospholipid metabolism	R-HSA-1483257	9.913037e-01	0.004
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.913820e-01	0.004
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.913820e-01	0.004
Pyruvate metabolism	R-HSA-70268	9.915353e-01	0.004
COPII-mediated vesicle transport	R-HSA-204005	9.927007e-01	0.003
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.927007e-01	0.003
ECM proteoglycans	R-HSA-3000178	9.932536e-01	0.003
Gluconeogenesis	R-HSA-70263	9.934183e-01	0.003
Metal ion SLC transporters	R-HSA-425410	9.934183e-01	0.003
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.935835e-01	0.003
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.937718e-01	0.003
Formation of the cornified envelope	R-HSA-6809371	9.942367e-01	0.003
Diseases of carbohydrate metabolism	R-HSA-5663084	9.942392e-01	0.003
Eukaryotic Translation Elongation	R-HSA-156842	9.945048e-01	0.002
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.945048e-01	0.002
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.945107e-01	0.002
Transport to the Golgi and subsequent modification	R-HSA-948021	9.945970e-01	0.002
ROS and RNS production in phagocytes	R-HSA-1222556	9.946776e-01	0.002
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.948895e-01	0.002
Complex IV assembly	R-HSA-9864848	9.949737e-01	0.002
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.950795e-01	0.002
RNA Polymerase I Promoter Escape	R-HSA-73772	9.954057e-01	0.002
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.954057e-01	0.002
Nucleotide biosynthesis	R-HSA-8956320	9.958007e-01	0.002
Eukaryotic Translation Termination	R-HSA-72764	9.958931e-01	0.002
Neuronal System	R-HSA-112316	9.960199e-01	0.002
Interleukin-10 signaling	R-HSA-6783783	9.961266e-01	0.002
ABC transporter disorders	R-HSA-5619084	9.961266e-01	0.002
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.963854e-01	0.002
Synthesis of bile acids and bile salts	R-HSA-192105	9.969379e-01	0.001
Amyloid fiber formation	R-HSA-977225	9.969516e-01	0.001
ABC-family proteins mediated transport	R-HSA-382556	9.971556e-01	0.001
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.973211e-01	0.001
Peroxisomal protein import	R-HSA-9033241	9.975515e-01	0.001
Glutathione conjugation	R-HSA-156590	9.977620e-01	0.001
Signaling by Retinoic Acid	R-HSA-5362517	9.977620e-01	0.001
Protein localization	R-HSA-9609507	9.978389e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.978630e-01	0.001
Aquaporin-mediated transport	R-HSA-445717	9.979545e-01	0.001
Neutrophil degranulation	R-HSA-6798695	9.979648e-01	0.001
Adaptive Immune System	R-HSA-1280218	9.979727e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.980454e-01	0.001
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.981171e-01	0.001
Neddylation	R-HSA-8951664	9.981642e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.982913e-01	0.001
Peptide chain elongation	R-HSA-156902	9.983978e-01	0.001
Stimuli-sensing channels	R-HSA-2672351	9.985439e-01	0.001
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.986954e-01	0.001
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.987431e-01	0.001
Bile acid and bile salt metabolism	R-HSA-194068	9.987469e-01	0.001
Nicotinate metabolism	R-HSA-196807	9.988076e-01	0.001
FCERI mediated NF-kB activation	R-HSA-2871837	9.988086e-01	0.001
Leishmania infection	R-HSA-9658195	9.990397e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.990397e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.990917e-01	0.000
Collagen formation	R-HSA-1474290	9.990917e-01	0.000
Cardiac conduction	R-HSA-5576891	9.991104e-01	0.000
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.991628e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.991681e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.991681e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.992563e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.992888e-01	0.000
Ribosome-associated quality control	R-HSA-9948299	9.994995e-01	0.000
Selenocysteine synthesis	R-HSA-2408557	9.995275e-01	0.000
Cellular response to starvation	R-HSA-9711097	9.995422e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.995569e-01	0.000
Viral mRNA Translation	R-HSA-192823	9.995991e-01	0.000
rRNA processing	R-HSA-72312	9.996328e-01	0.000
Post-translational protein modification	R-HSA-597592	9.996548e-01	0.000
Platelet homeostasis	R-HSA-418346	9.997115e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.997749e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.998287e-01	0.000
Interferon alpha/beta signaling	R-HSA-909733	9.998839e-01	0.000
FCGR activation	R-HSA-2029481	9.999042e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999332e-01	0.000
Potassium Channels	R-HSA-1296071	9.999332e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999442e-01	0.000
Ion channel transport	R-HSA-983712	9.999526e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999573e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999645e-01	0.000
Infectious disease	R-HSA-5663205	9.999793e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999811e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999842e-01	0.000
Immune System	R-HSA-168256	9.999872e-01	0.000
Keratinization	R-HSA-6805567	9.999873e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999899e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999908e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999923e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999929e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999944e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999947e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999962e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999962e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999963e-01	0.000
Translation	R-HSA-72766	9.999964e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999965e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999982e-01	0.000
Disease	R-HSA-1643685	9.999983e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999987e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.999987e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999991e-01	0.000
Innate Immune System	R-HSA-168249	9.999993e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999994e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999994e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999995e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999996e-01	0.000
Complement cascade	R-HSA-166658	9.999996e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999997e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999998e-01	0.000
Drug ADME	R-HSA-9748784	9.999999e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999999e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000