BMPR2

Normalized values from positional scanning peptide array
TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O43852 S69 Sugiyama CALU HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S173 Sugiyama ANXA1 ANX1 LPC1 NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04406 Y320 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE_____
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733 Y287 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 PsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDDWGAWQKF
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P13674 Y282 Sugiyama P4HA1 P4HA ASDDQSDQKTTPKKKGVAVDyLPERQKyEMLCRGEGIKMTP
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P23396 S35 Sugiyama RPS3 OK/SW-cl.26 GIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATRT
P25205 Y19 Sugiyama MCM3 __MAGtVVLDDVELREAQRDyLDFLDDEEDQGIyQsKVREL
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P35613 S279 Sugiyama BSG UNQ6505/PRO21383 TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q13873 S1030 Sugiyama BMPR2 PPH1 HSKSSTAVyLAEGGTATTMVsKDIGMNCL____________
Q13873 S185 Sugiyama BMPR2 PPH1 IVALCFGYRMLTGDRKQGLHsMNMMEAAAsEPSLDLDNLKL
Q13873 S194 Sugiyama BMPR2 PPH1 MLTGDRKQGLHsMNMMEAAAsEPSLDLDNLKLLELIGRGRY
Q13873 S233 Sugiyama BMPR2 PPH1 RYGAVYKGSLDERPVAVKVFsFANRQNFINEKNIYRVPLME
Q13873 S375 Sugiyama BMPR2 PPH1 SMRLTGNRLVRPGEEDNAAIsEVGtIRYMAPEVLEGAVNLR
Q13873 S513 Sugiyama BMPR2 PPH1 TAQCAEERMAELMMIWERNKsVsPtVNPMsTAMQNERNLSH
Q13873 S515 Sugiyama BMPR2 PPH1 QCAEERMAELMMIWERNKsVsPtVNPMsTAMQNERNLSHNR
Q13873 S522 Sugiyama BMPR2 PPH1 AELMMIWERNKsVsPtVNPMsTAMQNERNLSHNRRVPKIGP
Q13873 S680 Sugiyama BMPR2 PPH1 EEDLETNKLDPKEVDKNLKEssDENLMEHsLKQFSGPDPLS
Q13873 S681 Sugiyama BMPR2 PPH1 EDLETNKLDPKEVDKNLKEssDENLMEHsLKQFSGPDPLSS
Q13873 S689 Sugiyama BMPR2 PPH1 DPKEVDKNLKEssDENLMEHsLKQFSGPDPLSSTSSSLLyP
Q13873 S862 Sugiyama BMPR2 PPH1 RAQEMLQNQFIGEDTRLNINssPDEHEPLLRREQQAGHDEG
Q13873 T517 Sugiyama BMPR2 PPH1 AEERMAELMMIWERNKsVsPtVNPMsTAMQNERNLSHNRRV
Q13873 T793 Sugiyama BMPR2 PPH1 FGSKHKSNLKQVETGVAKMNtINAAEPHVVtVtMNGVAGRN
Q13873 T803 Sugiyama BMPR2 PPH1 QVETGVAKMNtINAAEPHVVtVtMNGVAGRNHSVNsHAATt
Q13873 T805 Sugiyama BMPR2 PPH1 ETGVAKMNtINAAEPHVVtVtMNGVAGRNHSVNsHAATtQY
Q13873 Y1018 Sugiyama BMPR2 PPH1 CEVNNNGSNRAVHSKSSTAVyLAEGGTATTMVsKDIGMNCL
Q15181 S127 Sugiyama PPA1 IOPPP PP NDKHTGCCGDNDPIDVCEIGsKVCARGEIIGVKVLGILAMI
Q15293 S80 Sugiyama RCN1 RCN HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q99676 T167 Sugiyama ZNF184 EGSLERQQANQQTLPKEIKVtEKTIPSWEKGPVNNEFGKSV
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9NRX4 T119 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 PAQHAISTEKIKAKyPDyEVtWANDGy______________
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 7.216450e-15 14.142 0 0
Cell Cycle, Mitotic R-HSA-69278 1.093459e-12 11.961 0 0
Chromatin organization R-HSA-4839726 2.442724e-11 10.612 0 0
Chromatin modifying enzymes R-HSA-3247509 7.199796e-11 10.143 0 0
M Phase R-HSA-68886 8.050725e-10 9.094 0 0
Cell Cycle Checkpoints R-HSA-69620 5.099539e-09 8.292 0 0
Mitotic Prometaphase R-HSA-68877 1.543974e-08 7.811 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.046342e-08 7.094 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.459117e-08 7.073 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.233071e-07 6.909 0 0
G2/M Checkpoints R-HSA-69481 1.623028e-07 6.790 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.291994e-07 6.640 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.197292e-07 6.658 0 0
ESR-mediated signaling R-HSA-8939211 3.478838e-07 6.459 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.467429e-07 6.189 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.586954e-07 6.181 0 0
Homology Directed Repair R-HSA-5693538 1.312140e-06 5.882 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.497256e-06 5.825 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.657519e-06 5.781 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.946906e-06 5.711 0 0
Mitotic Anaphase R-HSA-68882 2.914350e-06 5.535 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.349424e-06 5.475 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.516403e-06 5.345 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.843356e-06 5.053 0 0
Mitotic Prophase R-HSA-68875 9.242616e-06 5.034 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.109592e-05 4.955 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.299802e-05 4.886 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.708474e-05 4.767 0 0
Apoptotic execution phase R-HSA-75153 1.743634e-05 4.759 0 0
Separation of Sister Chromatids R-HSA-2467813 1.941962e-05 4.712 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.110819e-05 4.676 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.262291e-05 4.645 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.726656e-05 4.564 0 0
DNA Double Strand Break Response R-HSA-5693606 3.138242e-05 4.503 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.288035e-05 4.483 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.403296e-05 4.468 0 0
Myogenesis R-HSA-525793 3.382159e-05 4.471 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.967749e-05 4.401 0 0
Regulation of TP53 Activity R-HSA-5633007 3.963364e-05 4.402 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.020728e-05 4.396 0 0
Metabolism of RNA R-HSA-8953854 3.946325e-05 4.404 0 0
mRNA Splicing R-HSA-72172 4.117710e-05 4.385 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.115797e-05 4.291 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.424306e-05 4.266 0 0
HATs acetylate histones R-HSA-3214847 5.289273e-05 4.277 0 0
Deubiquitination R-HSA-5688426 6.437388e-05 4.191 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.014400e-05 4.154 0 0
G2/M Transition R-HSA-69275 6.949001e-05 4.158 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.316500e-05 4.136 0 0
HDACs deacetylate histones R-HSA-3214815 7.133256e-05 4.147 0 0
Kinesins R-HSA-983189 9.307440e-05 4.031 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.774736e-05 4.010 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.039893e-04 3.983 0 0
Signaling by VEGF R-HSA-194138 1.043747e-04 3.981 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.117178e-04 3.952 0 0
DNA Repair R-HSA-73894 1.270931e-04 3.896 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.502413e-04 3.823 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.476281e-04 3.831 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.502413e-04 3.823 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.589738e-04 3.799 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.770562e-04 3.752 0 0
Post NMDA receptor activation events R-HSA-438064 1.897824e-04 3.722 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.043189e-04 3.690 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.160395e-04 3.665 0 0
Cell-Cell communication R-HSA-1500931 2.146377e-04 3.668 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.242897e-04 3.649 0 0
Signaling by ERBB2 R-HSA-1227986 2.242897e-04 3.649 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.414430e-04 3.617 0 0
Signaling by ALK in cancer R-HSA-9700206 2.414430e-04 3.617 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.633822e-04 3.579 0 0
Nucleosome assembly R-HSA-774815 2.633822e-04 3.579 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.766126e-04 3.558 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.410819e-04 3.467 0 0
Heme signaling R-HSA-9707616 3.412624e-04 3.467 0 0
Signaling by Hippo R-HSA-2028269 3.633099e-04 3.440 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.903135e-04 3.409 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.137310e-04 3.383 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.591588e-04 3.338 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.942504e-04 3.306 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.348702e-04 3.272 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.454216e-04 3.263 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.779176e-04 3.238 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.779176e-04 3.238 0 0
L1CAM interactions R-HSA-373760 6.309320e-04 3.200 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.473045e-04 3.189 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.494372e-04 3.187 0 0
RNA Polymerase I Transcription R-HSA-73864 6.536454e-04 3.185 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 6.571682e-04 3.182 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.199362e-04 3.143 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.446345e-04 3.128 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.306045e-04 3.031 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.306045e-04 3.031 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 9.493883e-04 3.023 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 9.934190e-04 3.003 0 0
Aggrephagy R-HSA-9646399 1.013342e-03 2.994 0 0
Recycling pathway of L1 R-HSA-437239 1.023370e-03 2.990 0 0
EPH-Ephrin signaling R-HSA-2682334 1.042524e-03 2.982 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.085621e-03 2.964 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.251704e-03 2.902 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.251704e-03 2.902 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.189867e-03 2.925 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.189867e-03 2.925 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.249673e-03 2.903 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.267758e-03 2.897 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.274461e-03 2.895 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.388276e-03 2.858 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.392900e-03 2.856 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.392900e-03 2.856 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.398148e-03 2.854 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.502029e-03 2.823 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.594408e-03 2.797 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.674897e-03 2.776 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.729541e-03 2.762 0 0
IRE1alpha activates chaperones R-HSA-381070 1.741539e-03 2.759 0 0
Gene expression (Transcription) R-HSA-74160 1.786944e-03 2.748 0 0
Selective autophagy R-HSA-9663891 1.872273e-03 2.728 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.969663e-03 2.706 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.978931e-03 2.704 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.041801e-03 2.690 0 0
Ub-specific processing proteases R-HSA-5689880 2.042861e-03 2.690 0 0
Cellular responses to stimuli R-HSA-8953897 2.205062e-03 2.657 0 0
Cell junction organization R-HSA-446728 2.208500e-03 2.656 0 0
Axon guidance R-HSA-422475 2.213851e-03 2.655 0 0
Regulation of signaling by CBL R-HSA-912631 2.439658e-03 2.613 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.447495e-03 2.611 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.447495e-03 2.611 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.465117e-03 2.608 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.494814e-03 2.603 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.547447e-03 2.594 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.555978e-03 2.592 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.581113e-03 2.588 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.687023e-03 2.571 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.925940e-03 2.534 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.751693e-03 2.560 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.795072e-03 2.554 0 0
Nervous system development R-HSA-9675108 2.864013e-03 2.543 0 0
Membrane Trafficking R-HSA-199991 2.992460e-03 2.524 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.037260e-03 2.518 0 0
DAP12 signaling R-HSA-2424491 3.039552e-03 2.517 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.266108e-03 2.486 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.369546e-03 2.472 0 0
Nephrin family interactions R-HSA-373753 3.308122e-03 2.480 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.308122e-03 2.480 0 0
Meiotic synapsis R-HSA-1221632 3.296764e-03 2.482 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.305839e-03 2.481 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.305839e-03 2.481 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.595611e-03 2.444 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.431253e-03 2.465 0 0
Packaging Of Telomere Ends R-HSA-171306 3.771638e-03 2.423 0 0
Depurination R-HSA-73927 3.808427e-03 2.419 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.858002e-03 2.414 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.054933e-03 2.392 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.078346e-03 2.390 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.537996e-03 2.343 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.537996e-03 2.343 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.537996e-03 2.343 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.537996e-03 2.343 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.537996e-03 2.343 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.537996e-03 2.343 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.537996e-03 2.343 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.537996e-03 2.343 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.537996e-03 2.343 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.537996e-03 2.343 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.537996e-03 2.343 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.408530e-03 2.356 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.408530e-03 2.356 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.490785e-03 2.348 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.199006e-03 2.377 0 0
Cellular responses to stress R-HSA-2262752 4.636861e-03 2.334 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.669388e-03 2.331 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.674123e-03 2.330 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.779530e-03 2.321 0 0
Signalling to ERKs R-HSA-187687 4.779530e-03 2.321 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.805064e-03 2.318 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.844427e-03 2.315 0 0
MET activates RAS signaling R-HSA-8851805 5.501182e-03 2.260 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.682804e-03 2.245 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.682804e-03 2.245 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.173418e-03 2.286 0 0
Signaling by EGFR R-HSA-177929 5.497559e-03 2.260 0 0
Polo-like kinase mediated events R-HSA-156711 5.373849e-03 2.270 0 0
Signaling by LTK R-HSA-9842663 5.501182e-03 2.260 0 0
Macroautophagy R-HSA-1632852 5.595891e-03 2.252 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.209458e-03 2.283 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.612743e-03 2.251 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.781571e-03 2.238 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.872095e-03 2.231 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.872095e-03 2.231 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.993103e-03 2.222 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.993103e-03 2.222 0 0
HDMs demethylate histones R-HSA-3214842 5.993103e-03 2.222 0 0
Integrin signaling R-HSA-354192 6.003934e-03 2.222 0 0
DNA methylation R-HSA-5334118 6.054459e-03 2.218 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.054459e-03 2.218 0 0
Co-stimulation by CD28 R-HSA-389356 6.200445e-03 2.208 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.221046e-03 2.206 0 0
Cellular Senescence R-HSA-2559583 6.260139e-03 2.203 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.380474e-03 2.195 0 0
SOS-mediated signalling R-HSA-112412 6.663098e-03 2.176 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.157433e-03 2.145 0 0
Centrosome maturation R-HSA-380287 6.435907e-03 2.191 0 0
Chromosome Maintenance R-HSA-73886 6.459747e-03 2.190 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.967947e-03 2.157 0 0
Cleavage of the damaged purine R-HSA-110331 7.157433e-03 2.145 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.435907e-03 2.191 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.470587e-03 2.127 0 0
Signaling by KIT in disease R-HSA-9669938 7.470587e-03 2.127 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.549807e-03 2.122 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.549807e-03 2.122 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.590696e-03 2.120 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.141797e-03 2.089 0 0
Adherens junctions interactions R-HSA-418990 8.222844e-03 2.085 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.255224e-03 2.083 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.027701e-03 2.044 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.027701e-03 2.044 0 0
PECAM1 interactions R-HSA-210990 9.107331e-03 2.041 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.162475e-03 2.038 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 9.172092e-03 2.038 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.248101e-03 2.034 0 0
Diseases of DNA repair R-HSA-9675135 9.248101e-03 2.034 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.459629e-03 2.024 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.466234e-03 2.024 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.090522e-02 1.962 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.031349e-02 1.987 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.039883e-02 1.983 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.013860e-02 1.994 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.084048e-02 1.965 0 0
Autophagy R-HSA-9612973 9.871252e-03 2.006 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.083748e-02 1.965 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.090522e-02 1.962 0 0
Regulation of KIT signaling R-HSA-1433559 1.067743e-02 1.972 0 0
G0 and Early G1 R-HSA-1538133 1.140535e-02 1.943 0 0
mRNA 3'-end processing R-HSA-72187 1.186669e-02 1.926 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.186669e-02 1.926 0 0
Signalling to RAS R-HSA-167044 1.194569e-02 1.923 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.197974e-02 1.922 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.197974e-02 1.922 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.286956e-02 1.890 0 0
RUNX2 regulates bone development R-HSA-8941326 1.314005e-02 1.881 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.349803e-02 1.870 0 0
Cell-cell junction organization R-HSA-421270 1.352514e-02 1.869 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.383158e-02 1.859 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.383158e-02 1.859 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.383158e-02 1.859 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.383158e-02 1.859 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.383158e-02 1.859 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.417263e-02 1.849 0 0
Erythropoietin activates RAS R-HSA-9027284 1.432074e-02 1.844 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.432074e-02 1.844 0 0
RNA Polymerase II Transcription R-HSA-73857 1.441952e-02 1.841 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.443632e-02 1.841 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.469697e-02 1.833 0 0
FLT3 Signaling R-HSA-9607240 1.469697e-02 1.833 0 0
Gap junction trafficking and regulation R-HSA-157858 1.490020e-02 1.827 0 0
Ephrin signaling R-HSA-3928664 1.498766e-02 1.824 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.519646e-02 1.818 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.511956e-02 1.820 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.663509e-02 1.779 0 0
Metabolism of non-coding RNA R-HSA-194441 1.683912e-02 1.774 0 0
snRNP Assembly R-HSA-191859 1.683912e-02 1.774 0 0
Activation of the pre-replicative complex R-HSA-68962 1.753393e-02 1.756 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.607695e-02 1.794 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.637692e-02 1.786 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.511956e-02 1.820 0 0
Unwinding of DNA R-HSA-176974 1.519646e-02 1.818 0 0
Gene Silencing by RNA R-HSA-211000 1.547489e-02 1.810 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.763578e-02 1.754 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.792769e-02 1.746 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.797630e-02 1.745 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.831256e-02 1.737 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.857071e-02 1.731 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.879322e-02 1.726 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.885962e-02 1.724 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.910864e-02 1.719 0 0
Signal Transduction R-HSA-162582 1.919927e-02 1.717 1 0
Regulation of PTEN gene transcription R-HSA-8943724 1.924697e-02 1.716 0 0
Gap junction assembly R-HSA-190861 1.984971e-02 1.702 0 0
Meiotic recombination R-HSA-912446 1.996013e-02 1.700 0 0
MTOR signalling R-HSA-165159 2.025382e-02 1.693 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.025382e-02 1.693 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.025382e-02 1.693 0 0
Depyrimidination R-HSA-73928 2.025382e-02 1.693 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.148612e-02 1.668 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.148612e-02 1.668 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.399345e-02 1.620 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.399345e-02 1.620 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.399345e-02 1.620 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.399345e-02 1.620 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.399345e-02 1.620 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.399345e-02 1.620 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.328886e-02 1.633 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.170253e-02 1.663 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.067468e-02 1.685 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.202877e-02 1.657 0 0
PKR-mediated signaling R-HSA-9833482 2.166750e-02 1.664 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.252113e-02 1.647 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.202763e-02 1.657 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.185330e-02 1.660 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.228105e-02 1.652 0 0
Signal attenuation R-HSA-74749 2.148612e-02 1.668 0 0
Oncogene Induced Senescence R-HSA-2559585 2.350884e-02 1.629 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.420808e-02 1.616 0 0
Meiosis R-HSA-1500620 2.202763e-02 1.657 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.191249e-02 1.659 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.350884e-02 1.629 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.350736e-02 1.629 0 0
Cilium Assembly R-HSA-5617833 2.073004e-02 1.683 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.244894e-02 1.649 0 0
Signaling by SCF-KIT R-HSA-1433557 2.356792e-02 1.628 0 0
Apoptosis R-HSA-109581 2.443295e-02 1.612 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.066911e-02 1.685 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.185330e-02 1.660 0 0
Protein ubiquitination R-HSA-8852135 2.121987e-02 1.673 0 0
Interleukin-12 signaling R-HSA-9020591 2.380042e-02 1.623 0 0
Base Excision Repair R-HSA-73884 2.476023e-02 1.606 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.485193e-02 1.605 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.562590e-02 1.591 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.562590e-02 1.591 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.727250e-02 1.564 0 0
Gap junction trafficking R-HSA-190828 2.727250e-02 1.564 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.741371e-02 1.562 0 0
Signaling by NTRKs R-HSA-166520 2.749008e-02 1.561 0 0
Semaphorin interactions R-HSA-373755 2.808135e-02 1.552 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.821223e-02 1.550 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.912800e-02 1.536 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.933277e-02 1.533 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.982335e-02 1.525 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.982335e-02 1.525 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.988726e-02 1.525 0 0
Interferon Signaling R-HSA-913531 3.028914e-02 1.519 0 0
MHC class II antigen presentation R-HSA-2132295 3.201162e-02 1.495 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.228941e-02 1.491 0 0
Diseases of programmed cell death R-HSA-9645723 3.333295e-02 1.477 0 0
Protein folding R-HSA-391251 3.336765e-02 1.477 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.424770e-02 1.465 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.504194e-02 1.455 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.625189e-02 1.441 0 0
Telomere Maintenance R-HSA-157579 3.655953e-02 1.437 0 0
Signaling by MET R-HSA-6806834 3.658952e-02 1.437 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.747151e-02 1.426 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.788019e-02 1.422 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.792737e-02 1.421 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.792737e-02 1.421 0 0
Tie2 Signaling R-HSA-210993 3.803215e-02 1.420 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.885702e-02 1.411 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.908135e-02 1.408 0 0
p38MAPK events R-HSA-171007 3.908135e-02 1.408 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 4.311669e-02 1.365 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 4.311669e-02 1.365 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 4.311669e-02 1.365 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.386356e-02 1.358 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.386356e-02 1.358 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.923404e-02 1.308 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.923404e-02 1.308 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.923404e-02 1.308 0 0
mTORC1-mediated signalling R-HSA-166208 4.384862e-02 1.358 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.452113e-02 1.351 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.452113e-02 1.351 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.942131e-02 1.404 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.216725e-02 1.375 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.752068e-02 1.323 0 0
Post-translational protein phosphorylation R-HSA-8957275 4.001917e-02 1.398 0 0
HCMV Early Events R-HSA-9609690 4.391074e-02 1.357 0 0
Mitochondrial biogenesis R-HSA-1592230 4.534629e-02 1.343 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.923404e-02 1.308 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.087780e-02 1.389 0 0
Downstream signal transduction R-HSA-186763 4.452113e-02 1.351 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.331824e-02 1.363 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.238553e-02 1.373 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.089432e-02 1.388 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.880150e-02 1.312 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.837336e-02 1.315 0 0
Smooth Muscle Contraction R-HSA-445355 4.752068e-02 1.323 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.837336e-02 1.315 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.496579e-02 1.347 0 0
Defective pyroptosis R-HSA-9710421 4.505174e-02 1.346 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.924649e-02 1.308 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.955530e-02 1.305 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.995196e-02 1.301 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.995196e-02 1.301 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.995196e-02 1.301 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.995196e-02 1.301 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.014587e-02 1.300 0 0
DAP12 interactions R-HSA-2172127 5.122304e-02 1.291 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 5.122304e-02 1.291 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.185376e-02 1.285 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.237111e-02 1.281 0 0
Syndecan interactions R-HSA-3000170 5.237111e-02 1.281 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.435560e-02 1.265 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.439134e-02 1.264 0 0
GPVI-mediated activation cascade R-HSA-114604 5.451513e-02 1.263 0 0
FLT3 signaling in disease R-HSA-9682385 5.451513e-02 1.263 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.638724e-02 1.249 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.650348e-02 1.248 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.650348e-02 1.248 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.706673e-02 1.244 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.996966e-02 1.222 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.996966e-02 1.222 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.017501e-02 1.221 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.017501e-02 1.221 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.190918e-02 1.208 0 0
Neurodegenerative Diseases R-HSA-8863678 6.190918e-02 1.208 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.207530e-02 1.207 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.207530e-02 1.207 0 0
Nef and signal transduction R-HSA-164944 6.207530e-02 1.207 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.207530e-02 1.207 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.236410e-02 1.205 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.236410e-02 1.205 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 6.325065e-02 1.199 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.408166e-02 1.193 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.462189e-02 1.190 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 6.462189e-02 1.190 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.462189e-02 1.190 0 0
Signaling by NOTCH R-HSA-157118 6.500367e-02 1.187 0 0
Signaling by Erythropoietin R-HSA-9006335 6.595280e-02 1.181 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.595280e-02 1.181 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.595280e-02 1.181 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.612109e-02 1.180 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.713125e-02 1.173 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.866411e-02 1.163 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.887137e-02 1.162 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.887137e-02 1.162 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.248610e-02 1.140 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.248610e-02 1.140 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.290837e-02 1.137 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 8.733147e-02 1.059 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 7.681641e-02 1.115 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 7.681641e-02 1.115 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 7.681641e-02 1.115 0 0
MECP2 regulates transcription factors R-HSA-9022707 8.366477e-02 1.077 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.493350e-02 1.023 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.493350e-02 1.023 0 0
Notch-HLH transcription pathway R-HSA-350054 9.299242e-02 1.032 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.609694e-02 1.119 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.679625e-02 1.014 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.679625e-02 1.014 0 0
Generation of second messenger molecules R-HSA-202433 9.022574e-02 1.045 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.675103e-02 1.062 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.675103e-02 1.062 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.675103e-02 1.062 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.711395e-02 1.060 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.711395e-02 1.060 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.417593e-02 1.075 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 9.679625e-02 1.014 0 0
Generic Transcription Pathway R-HSA-212436 8.224128e-02 1.085 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 7.681641e-02 1.115 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 8.366477e-02 1.077 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.239981e-02 1.084 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.493350e-02 1.023 0 0
DNA strand elongation R-HSA-69190 9.914432e-02 1.004 0 0
G alpha (12/13) signalling events R-HSA-416482 7.850790e-02 1.105 0 0
Signaling by FGFR4 R-HSA-5654743 8.118417e-02 1.091 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 7.681641e-02 1.115 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.711395e-02 1.060 0 0
TBC/RABGAPs R-HSA-8854214 8.118417e-02 1.091 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 8.366477e-02 1.077 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.493350e-02 1.023 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.493350e-02 1.023 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.493350e-02 1.023 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.818651e-02 1.107 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.493350e-02 1.023 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.022574e-02 1.045 0 0
Potential therapeutics for SARS R-HSA-9679191 9.225020e-02 1.035 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.810842e-02 1.107 0 0
Nuclear import of Rev protein R-HSA-180746 7.857978e-02 1.105 0 0
Interleukin-12 family signaling R-HSA-447115 7.631123e-02 1.117 0 0
Interleukin-37 signaling R-HSA-9008059 7.609694e-02 1.119 0 0
RET signaling R-HSA-8853659 1.004450e-01 0.998 0 0
Signaling by FGFR3 R-HSA-5654741 1.009365e-01 0.996 0 0
Activation of RAC1 R-HSA-428540 1.024927e-01 0.989 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.024927e-01 0.989 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.024927e-01 0.989 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.027751e-01 0.988 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.027751e-01 0.988 0 0
Programmed Cell Death R-HSA-5357801 1.028252e-01 0.988 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 1.063414e-01 0.973 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.065730e-01 0.972 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.076383e-01 0.968 0 0
Type I hemidesmosome assembly R-HSA-446107 1.084191e-01 0.965 0 0
MET receptor recycling R-HSA-8875656 1.084191e-01 0.965 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.086813e-01 0.964 0 0
NrCAM interactions R-HSA-447038 1.086813e-01 0.964 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.086813e-01 0.964 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.086813e-01 0.964 0 0
DNA Replication R-HSA-69306 1.094230e-01 0.961 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.094783e-01 0.961 0 0
HIV elongation arrest and recovery R-HSA-167287 1.105222e-01 0.957 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.105222e-01 0.957 0 0
Signaling by RAS mutants R-HSA-6802949 1.118118e-01 0.952 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.118118e-01 0.952 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.118118e-01 0.952 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.118118e-01 0.952 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.120433e-01 0.951 0 0
S Phase R-HSA-69242 1.124163e-01 0.949 0 0
MAP2K and MAPK activation R-HSA-5674135 1.124609e-01 0.949 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.134387e-01 0.945 0 0
tRNA processing in the nucleus R-HSA-6784531 1.178302e-01 0.929 0 0
G1/S Transition R-HSA-69206 1.215565e-01 0.915 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.217126e-01 0.915 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.233475e-01 0.909 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.233475e-01 0.909 0 0
Repression of WNT target genes R-HSA-4641265 1.247734e-01 0.904 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.247734e-01 0.904 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.247734e-01 0.904 0 0
Interleukin-15 signaling R-HSA-8983432 1.247734e-01 0.904 0 0
Cellular response to heat stress R-HSA-3371556 1.249086e-01 0.903 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.252727e-01 0.902 0 0
MET promotes cell motility R-HSA-8875878 1.255585e-01 0.901 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.258030e-01 0.900 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.258426e-01 0.900 0 0
Striated Muscle Contraction R-HSA-390522 1.258426e-01 0.900 0 0
Vesicle-mediated transport R-HSA-5653656 1.274477e-01 0.895 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.307812e-01 0.883 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.336194e-01 0.874 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.336194e-01 0.874 0 0
Intraflagellar transport R-HSA-5620924 1.355345e-01 0.868 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 1.360381e-01 0.866 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.360381e-01 0.866 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.360381e-01 0.866 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.380176e-01 0.860 0 0
Basigin interactions R-HSA-210991 1.382947e-01 0.859 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.394978e-01 0.855 0 0
Regulation of TP53 Expression R-HSA-6804754 1.399821e-01 0.854 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.399821e-01 0.854 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.399821e-01 0.854 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.399821e-01 0.854 0 0
Circadian clock R-HSA-9909396 1.403084e-01 0.853 0 0
TGFBR3 expression R-HSA-9839394 1.404567e-01 0.852 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.405202e-01 0.852 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.410180e-01 0.851 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.444849e-01 0.840 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.447123e-01 0.839 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.447123e-01 0.839 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.447123e-01 0.839 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.447123e-01 0.839 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.447123e-01 0.839 0 0
Translation initiation complex formation R-HSA-72649 1.453553e-01 0.838 0 0
Signaling by WNT R-HSA-195721 1.469469e-01 0.833 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.481501e-01 0.829 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.483438e-01 0.829 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.483438e-01 0.829 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.490719e-01 0.827 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.490719e-01 0.827 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.490719e-01 0.827 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.490719e-01 0.827 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.490719e-01 0.827 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.490719e-01 0.827 0 0
Amyloid fiber formation R-HSA-977225 1.497619e-01 0.825 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.508462e-01 0.821 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.508462e-01 0.821 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.508462e-01 0.821 0 0
Defective OGG1 Localization R-HSA-9657050 1.508462e-01 0.821 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.508462e-01 0.821 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.508462e-01 0.821 0 0
MET interacts with TNS proteins R-HSA-8875513 1.975194e-01 0.704 0 0
MET activates PTPN11 R-HSA-8865999 1.975194e-01 0.704 0 0
CREB phosphorylation R-HSA-199920 1.840192e-01 0.735 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.840192e-01 0.735 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.661601e-01 0.779 0 0
CHL1 interactions R-HSA-447041 2.257210e-01 0.646 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.257210e-01 0.646 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.257210e-01 0.646 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.257210e-01 0.646 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.257210e-01 0.646 0 0
Regulation of PTEN localization R-HSA-8948747 2.257210e-01 0.646 0 0
VLDL clearance R-HSA-8964046 2.257210e-01 0.646 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.257210e-01 0.646 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.983858e-01 0.702 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.983858e-01 0.702 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.751836e-01 0.757 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.751836e-01 0.757 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.028794e-01 0.693 0 0
GAB1 signalosome R-HSA-180292 1.785498e-01 0.748 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.580214e-01 0.801 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.580214e-01 0.801 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.580214e-01 0.801 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.030204e-01 0.692 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.776436e-01 0.750 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.776436e-01 0.750 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.538125e-01 0.813 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.538125e-01 0.813 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.239577e-01 0.650 0 0
Deadenylation of mRNA R-HSA-429947 2.239577e-01 0.650 0 0
G1/S-Specific Transcription R-HSA-69205 1.723844e-01 0.764 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.723844e-01 0.764 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.654971e-01 0.781 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.798491e-01 0.745 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.056326e-01 0.687 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.698359e-01 0.770 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.195595e-01 0.658 0 0
PTEN Regulation R-HSA-6807070 1.598064e-01 0.796 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.621486e-01 0.790 0 0
RNA Polymerase III Transcription R-HSA-74158 1.723844e-01 0.764 0 0
IGF1R signaling cascade R-HSA-2428924 2.073759e-01 0.683 0 0
G-protein beta:gamma signalling R-HSA-397795 1.937848e-01 0.713 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.130310e-01 0.672 0 0
TCR signaling R-HSA-202403 2.082855e-01 0.681 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 2.257210e-01 0.646 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.840192e-01 0.735 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.661601e-01 0.779 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.218151e-01 0.654 0 0
DCC mediated attractive signaling R-HSA-418885 2.028794e-01 0.693 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.894912e-01 0.722 0 0
Regulation of CDH11 function R-HSA-9762292 1.661601e-01 0.779 0 0
PI3K/AKT activation R-HSA-198203 1.661601e-01 0.779 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.789446e-01 0.747 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.239577e-01 0.650 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.035505e-01 0.691 0 0
Signaling by FGFR2 R-HSA-5654738 2.010921e-01 0.697 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.009612e-01 0.697 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.560464e-01 0.807 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.186428e-01 0.660 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.654971e-01 0.781 0 0
Metalloprotease DUBs R-HSA-5689901 1.585351e-01 0.800 0 0
Platelet degranulation R-HSA-114608 1.839261e-01 0.735 0 0
rRNA processing R-HSA-72312 1.610895e-01 0.793 0 0
Signaling by TGFB family members R-HSA-9006936 2.033281e-01 0.692 1 0
Signaling by FGFR1 in disease R-HSA-5655302 1.850038e-01 0.733 0 0
NRAGE signals death through JNK R-HSA-193648 1.712967e-01 0.766 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.690572e-01 0.772 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.137431e-01 0.670 0 0
Signaling by LTK in cancer R-HSA-9842640 1.840192e-01 0.735 0 0
Signaling by TGFBR3 R-HSA-9839373 1.804330e-01 0.744 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.121169e-01 0.673 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.886843e-01 0.724 0 0
Signaling by ERBB4 R-HSA-1236394 1.946465e-01 0.711 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.257210e-01 0.646 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.804330e-01 0.744 0 0
Glycolysis R-HSA-70171 2.105437e-01 0.677 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.257210e-01 0.646 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.073177e-01 0.683 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.690572e-01 0.772 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.258097e-01 0.646 0 0
Signaling by ALK R-HSA-201556 2.258097e-01 0.646 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.265061e-01 0.645 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.270201e-01 0.644 0 0
Prolonged ERK activation events R-HSA-169893 2.319134e-01 0.635 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.319134e-01 0.635 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.322975e-01 0.634 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.322975e-01 0.634 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.322975e-01 0.634 0 0
Integration of provirus R-HSA-162592 2.322975e-01 0.634 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.322975e-01 0.634 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 2.329956e-01 0.633 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.329956e-01 0.633 0 0
Netrin-1 signaling R-HSA-373752 2.366480e-01 0.626 0 0
Signaling by NOTCH3 R-HSA-9012852 2.374740e-01 0.624 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.403596e-01 0.619 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.403596e-01 0.619 0 0
Activation of BH3-only proteins R-HSA-114452 2.403596e-01 0.619 0 0
Developmental Biology R-HSA-1266738 2.417283e-01 0.617 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.789452e-01 0.554 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.789452e-01 0.554 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.789452e-01 0.554 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.789452e-01 0.554 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.789452e-01 0.554 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.789452e-01 0.554 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.789452e-01 0.554 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.789452e-01 0.554 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.789452e-01 0.554 0 0
Hereditary fructose intolerance R-HSA-5657560 2.789452e-01 0.554 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.789452e-01 0.554 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.789452e-01 0.554 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.789452e-01 0.554 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.572724e-01 0.590 0 0
Regulation of gap junction activity R-HSA-191650 2.572724e-01 0.590 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.572724e-01 0.590 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.572724e-01 0.590 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.572724e-01 0.590 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.877260e-01 0.411 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 3.877260e-01 0.411 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.877260e-01 0.411 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.877260e-01 0.411 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.877260e-01 0.411 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.877260e-01 0.411 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 3.877260e-01 0.411 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.877260e-01 0.411 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.877260e-01 0.411 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.877260e-01 0.411 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.877260e-01 0.411 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.877260e-01 0.411 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.877260e-01 0.411 0 0
Reelin signalling pathway R-HSA-8866376 3.172642e-01 0.499 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.172642e-01 0.499 0 0
IRS activation R-HSA-74713 3.172642e-01 0.499 0 0
Activation of AKT2 R-HSA-165158 3.172642e-01 0.499 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.172642e-01 0.499 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.172642e-01 0.499 0 0
G2 Phase R-HSA-68911 3.172642e-01 0.499 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.172642e-01 0.499 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.172642e-01 0.499 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.172642e-01 0.499 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.172642e-01 0.499 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 2.689880e-01 0.570 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.689880e-01 0.570 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.689880e-01 0.570 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.689880e-01 0.570 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.674767e-01 0.573 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.674767e-01 0.573 0 0
Pervasive developmental disorders R-HSA-9005895 2.674767e-01 0.573 0 0
Disorders of Nervous System Development R-HSA-9697154 2.674767e-01 0.573 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.674767e-01 0.573 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.674767e-01 0.573 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.674767e-01 0.573 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.674767e-01 0.573 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.674767e-01 0.573 0 0
ARMS-mediated activation R-HSA-170984 3.130677e-01 0.504 0 0
WNT mediated activation of DVL R-HSA-201688 3.130677e-01 0.504 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.760637e-01 0.425 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.760637e-01 0.425 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.760637e-01 0.425 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.760637e-01 0.425 0 0
Phosphorylation of Emi1 R-HSA-176417 3.760637e-01 0.425 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.760637e-01 0.425 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.760637e-01 0.425 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.801011e-01 0.319 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.801011e-01 0.319 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.801011e-01 0.319 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.801011e-01 0.319 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.801011e-01 0.319 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.620313e-01 0.582 0 0
Disorders of Developmental Biology R-HSA-9675151 2.620313e-01 0.582 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.620313e-01 0.582 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.035166e-01 0.518 0 0
ERK/MAPK targets R-HSA-198753 2.551684e-01 0.593 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.551684e-01 0.593 0 0
2-LTR circle formation R-HSA-164843 3.572979e-01 0.447 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.572979e-01 0.447 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.929770e-01 0.533 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.824995e-01 0.549 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.400328e-01 0.468 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.326656e-01 0.364 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.326656e-01 0.364 0 0
STAT5 Activation R-HSA-9645135 4.326656e-01 0.364 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 4.326656e-01 0.364 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 4.326656e-01 0.364 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.244987e-01 0.489 0 0
Platelet sensitization by LDL R-HSA-432142 3.244987e-01 0.489 0 0
EGFR downregulation R-HSA-182971 2.627619e-01 0.580 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.011123e-01 0.397 0 0
Signaling by APC mutants R-HSA-4839744 4.011123e-01 0.397 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.011123e-01 0.397 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.011123e-01 0.397 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.011123e-01 0.397 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.449089e-01 0.611 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.766699e-01 0.424 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.766699e-01 0.424 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.766699e-01 0.424 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 3.563541e-01 0.448 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.387940e-01 0.470 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.232373e-01 0.490 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.232373e-01 0.490 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.737715e-01 0.563 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.052130e-01 0.515 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.674116e-01 0.435 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.674116e-01 0.435 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 3.674116e-01 0.435 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.674116e-01 0.435 0 0
Formation of definitive endoderm R-HSA-9823730 3.883139e-01 0.411 0 0
Negative regulation of MET activity R-HSA-6807004 3.883139e-01 0.411 0 0
Phosphorylation of the APC/C R-HSA-176412 4.131067e-01 0.384 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.131067e-01 0.384 0 0
Degradation of CDH1 R-HSA-9766229 3.324198e-01 0.478 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.201649e-01 0.377 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.490587e-01 0.348 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.247721e-01 0.372 0 0
MET activates PTK2 signaling R-HSA-8874081 4.247721e-01 0.372 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.856959e-01 0.314 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.856959e-01 0.314 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.856959e-01 0.314 0 0
Leading Strand Synthesis R-HSA-69109 4.856959e-01 0.314 0 0
Polymerase switching R-HSA-69091 4.856959e-01 0.314 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.901064e-01 0.409 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.517123e-01 0.345 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.517123e-01 0.345 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.030188e-01 0.519 0 0
Regulation of CDH1 Function R-HSA-9764561 3.763467e-01 0.424 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.241670e-01 0.489 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.532167e-01 0.344 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.532167e-01 0.344 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.842794e-01 0.315 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.842794e-01 0.315 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.417663e-01 0.466 0 0
FGFR2 alternative splicing R-HSA-6803529 4.827813e-01 0.316 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.827813e-01 0.316 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.813241e-01 0.318 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.654362e-01 0.332 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.654362e-01 0.332 0 0
Transcription of the HIV genome R-HSA-167172 3.640557e-01 0.439 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.030188e-01 0.519 0 0
Nucleotide Excision Repair R-HSA-5696398 2.842635e-01 0.546 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.091281e-01 0.388 0 0
HIV Transcription Elongation R-HSA-167169 2.449089e-01 0.611 0 0
Pexophagy R-HSA-9664873 3.572979e-01 0.447 0 0
Insulin receptor signalling cascade R-HSA-74751 3.980009e-01 0.400 0 0
RAF activation R-HSA-5673000 3.572053e-01 0.447 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.544516e-01 0.343 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.222687e-01 0.374 0 0
Interleukin-17 signaling R-HSA-448424 3.998406e-01 0.398 0 0
MAP kinase activation R-HSA-450294 3.423685e-01 0.466 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.011123e-01 0.397 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.397388e-01 0.469 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.222851e-01 0.374 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.674767e-01 0.573 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.918536e-01 0.535 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.449089e-01 0.611 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.929770e-01 0.533 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.440389e-01 0.353 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.201649e-01 0.377 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 4.532167e-01 0.344 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.329057e-01 0.478 0 0
Josephin domain DUBs R-HSA-5689877 3.572979e-01 0.447 0 0
Formation of the posterior neural plate R-HSA-9832991 4.011123e-01 0.397 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.547579e-01 0.342 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.220928e-01 0.375 0 0
Mitophagy R-HSA-5205647 3.572053e-01 0.447 0 0
HIV Life Cycle R-HSA-162587 2.863680e-01 0.543 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.813241e-01 0.318 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.220928e-01 0.375 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.638123e-01 0.334 0 0
Formation of apoptosome R-HSA-111458 3.572979e-01 0.447 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.857500e-01 0.544 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.131067e-01 0.384 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.842794e-01 0.315 0 0
FOXO-mediated transcription R-HSA-9614085 4.364482e-01 0.360 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.638123e-01 0.334 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.104331e-01 0.508 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.078007e-01 0.512 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.540798e-01 0.595 0 0
HIV Infection R-HSA-162906 4.202376e-01 0.377 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.763467e-01 0.424 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.139467e-01 0.503 0 0
Dopamine receptors R-HSA-390651 2.572724e-01 0.590 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.572724e-01 0.590 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.627619e-01 0.580 0 0
Signaling by WNT in cancer R-HSA-4791275 2.857500e-01 0.544 0 0
NF-kB is activated and signals survival R-HSA-209560 4.440389e-01 0.353 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.260933e-01 0.487 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.501779e-01 0.602 0 0
Trafficking of AMPA receptors R-HSA-399719 4.017155e-01 0.396 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.857500e-01 0.544 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.815133e-01 0.418 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.104331e-01 0.508 0 0
Neurexins and neuroligins R-HSA-6794361 3.932337e-01 0.405 0 0
Nuclear RNA decay R-HSA-9930044 4.540756e-01 0.343 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.964404e-01 0.528 0 0
Long-term potentiation R-HSA-9620244 3.961224e-01 0.402 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.856959e-01 0.314 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.815133e-01 0.418 0 0
Intra-Golgi traffic R-HSA-6811438 2.846766e-01 0.546 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.330822e-01 0.477 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.538611e-01 0.343 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.431565e-01 0.614 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.330822e-01 0.477 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.330822e-01 0.477 0 0
RMTs methylate histone arginines R-HSA-3214858 4.773525e-01 0.321 0 0
HCMV Infection R-HSA-9609646 2.991377e-01 0.524 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.361560e-01 0.360 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.877260e-01 0.411 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.172642e-01 0.499 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.130677e-01 0.504 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.572979e-01 0.447 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.400328e-01 0.468 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.440389e-01 0.353 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.754296e-01 0.425 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.490587e-01 0.348 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.799721e-01 0.319 0 0
Signaling by FGFR1 R-HSA-5654736 2.540798e-01 0.595 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.431565e-01 0.614 0 0
Apoptotic factor-mediated response R-HSA-111471 3.244987e-01 0.489 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.607791e-01 0.443 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.130677e-01 0.504 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.513400e-01 0.345 0 0
Integrin cell surface interactions R-HSA-216083 3.365218e-01 0.473 0 0
Host Interactions of HIV factors R-HSA-162909 3.307106e-01 0.481 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.035166e-01 0.518 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.723977e-01 0.565 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.766699e-01 0.424 0 0
Ca-dependent events R-HSA-111996 4.319718e-01 0.365 0 0
Signaling by NOTCH1 R-HSA-1980143 4.014084e-01 0.396 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.247721e-01 0.372 0 0
Neurofascin interactions R-HSA-447043 4.326656e-01 0.364 0 0
DAG and IP3 signaling R-HSA-1489509 3.686088e-01 0.433 0 0
Calmodulin induced events R-HSA-111933 4.059002e-01 0.392 0 0
Co-inhibition by PD-1 R-HSA-389948 4.430517e-01 0.354 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.689849e-01 0.329 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 3.883139e-01 0.411 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.842794e-01 0.315 0 0
CaM pathway R-HSA-111997 4.059002e-01 0.392 0 0
Hemostasis R-HSA-109582 2.963176e-01 0.528 0 0
NGF-stimulated transcription R-HSA-9031628 4.332452e-01 0.363 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.645529e-01 0.577 0 0
Formation of the anterior neural plate R-HSA-9823739 3.766699e-01 0.424 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.540756e-01 0.343 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.802643e-01 0.552 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.607582e-01 0.337 0 0
Inhibition of PKR R-HSA-169131 2.789452e-01 0.554 0 0
SDK interactions R-HSA-373756 2.789452e-01 0.554 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.572724e-01 0.590 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.877260e-01 0.411 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.877260e-01 0.411 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.172642e-01 0.499 0 0
Co-stimulation by ICOS R-HSA-9927354 2.689880e-01 0.570 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.760637e-01 0.425 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.760637e-01 0.425 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.801011e-01 0.319 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.801011e-01 0.319 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.801011e-01 0.319 0 0
Bicarbonate transporters R-HSA-425381 4.011123e-01 0.397 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.451227e-01 0.611 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.674116e-01 0.435 0 0
Signaling by AXIN mutants R-HSA-4839735 4.440389e-01 0.353 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.572053e-01 0.447 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.856959e-01 0.314 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.856959e-01 0.314 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.517123e-01 0.345 0 0
Rab regulation of trafficking R-HSA-9007101 3.943890e-01 0.404 0 0
Signaling by FGFR in disease R-HSA-1226099 4.718099e-01 0.326 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.572979e-01 0.447 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.540798e-01 0.595 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 4.201649e-01 0.377 0 0
Signal transduction by L1 R-HSA-445144 3.883139e-01 0.411 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.740466e-01 0.562 0 0
Signaling by PDGF R-HSA-186797 2.612064e-01 0.583 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.011123e-01 0.397 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 4.059002e-01 0.392 0 0
Signaling by PTK6 R-HSA-8848021 3.793379e-01 0.421 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.793379e-01 0.421 0 0
Suppression of apoptosis R-HSA-9635465 4.011123e-01 0.397 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.532167e-01 0.344 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.635067e-01 0.439 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.130677e-01 0.504 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.760637e-01 0.425 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.827813e-01 0.316 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.532167e-01 0.344 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.856959e-01 0.314 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.551684e-01 0.593 0 0
Death Receptor Signaling R-HSA-73887 3.173764e-01 0.498 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.877260e-01 0.411 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.035166e-01 0.518 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.131067e-01 0.384 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.440389e-01 0.353 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.540756e-01 0.343 0 0
Glucose metabolism R-HSA-70326 3.943890e-01 0.404 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.674767e-01 0.573 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.130677e-01 0.504 0 0
Signaling by Interleukins R-HSA-449147 3.101141e-01 0.508 0 0
Interleukin-7 signaling R-HSA-1266695 2.478123e-01 0.606 0 0
Diseases of Base Excision Repair R-HSA-9605308 3.760637e-01 0.425 0 0
Interleukin-2 family signaling R-HSA-451927 3.635067e-01 0.439 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.620313e-01 0.582 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.801011e-01 0.319 0 0
Leukotriene receptors R-HSA-391906 4.326656e-01 0.364 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.863949e-01 0.313 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 4.863949e-01 0.313 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.863949e-01 0.313 0 0
Disinhibition of SNARE formation R-HSA-114516 4.863949e-01 0.313 0 0
Recycling of eIF2:GDP R-HSA-72731 4.863949e-01 0.313 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.863949e-01 0.313 0 0
PTK6 Expression R-HSA-8849473 4.863949e-01 0.313 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.863949e-01 0.313 0 0
IRS-mediated signalling R-HSA-112399 4.952050e-01 0.305 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.960189e-01 0.305 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.960189e-01 0.305 0 0
Parasite infection R-HSA-9664407 5.005443e-01 0.301 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.005443e-01 0.301 0 0
Leishmania phagocytosis R-HSA-9664417 5.005443e-01 0.301 0 0
Signaling by Insulin receptor R-HSA-74752 5.012047e-01 0.300 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.024153e-01 0.299 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.054456e-01 0.296 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.089743e-01 0.293 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.089743e-01 0.293 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.107857e-01 0.292 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.132172e-01 0.290 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.132172e-01 0.290 0 0
Growth hormone receptor signaling R-HSA-982772 5.132172e-01 0.290 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.134667e-01 0.289 0 0
Signaling by FGFR R-HSA-190236 5.149327e-01 0.288 0 0
Reproduction R-HSA-1474165 5.170969e-01 0.286 0 0
MAPK family signaling cascades R-HSA-5683057 5.181864e-01 0.286 0 0
Orc1 removal from chromatin R-HSA-68949 5.183536e-01 0.285 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.183536e-01 0.285 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.185598e-01 0.285 0 0
PKA activation R-HSA-163615 5.185598e-01 0.285 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.185598e-01 0.285 0 0
Mismatch Repair R-HSA-5358508 5.185598e-01 0.285 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.254572e-01 0.279 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.254572e-01 0.279 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.257845e-01 0.279 0 0
Frs2-mediated activation R-HSA-170968 5.257845e-01 0.279 0 0
Formation of axial mesoderm R-HSA-9796292 5.257845e-01 0.279 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.257845e-01 0.279 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.257845e-01 0.279 0 0
Adipogenesis R-HSA-9843745 5.304511e-01 0.275 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.349857e-01 0.272 0 0
Extension of Telomeres R-HSA-180786 5.349868e-01 0.272 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 5.368303e-01 0.270 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.368303e-01 0.270 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 5.368303e-01 0.270 0 0
Formation of annular gap junctions R-HSA-196025 5.368303e-01 0.270 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 5.368303e-01 0.270 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.368303e-01 0.270 0 0
RSK activation R-HSA-444257 5.368303e-01 0.270 0 0
Activation of RAS in B cells R-HSA-1169092 5.368303e-01 0.270 0 0
TGFBR3 PTM regulation R-HSA-9839383 5.368303e-01 0.270 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 5.368303e-01 0.270 0 0
Adrenoceptors R-HSA-390696 5.368303e-01 0.270 0 0
Hedgehog 'off' state R-HSA-5610787 5.456628e-01 0.263 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.471218e-01 0.262 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.489259e-01 0.260 0 0
HIV Transcription Initiation R-HSA-167161 5.489259e-01 0.260 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.489259e-01 0.260 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.489259e-01 0.260 0 0
Influenza Infection R-HSA-168255 5.503051e-01 0.259 0 0
Translesion Synthesis by POLH R-HSA-110320 5.517273e-01 0.258 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.517273e-01 0.258 0 0
Rap1 signalling R-HSA-392517 5.517273e-01 0.258 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.517273e-01 0.258 0 0
Downstream TCR signaling R-HSA-202424 5.521005e-01 0.258 0 0
Inositol phosphate metabolism R-HSA-1483249 5.544423e-01 0.256 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.556899e-01 0.255 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.585438e-01 0.253 0 0
PLC-gamma1 signalling R-HSA-167021 5.585438e-01 0.253 0 0
Axonal growth stimulation R-HSA-209563 5.585438e-01 0.253 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.585438e-01 0.253 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 5.585438e-01 0.253 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 5.585438e-01 0.253 0 0
Invadopodia formation R-HSA-8941237 5.585438e-01 0.253 0 0
Defective ABCC2 causes DJS R-HSA-5679001 5.585438e-01 0.253 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 5.585438e-01 0.253 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.585438e-01 0.253 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 5.585438e-01 0.253 0 0
MET activates STAT3 R-HSA-8875791 5.585438e-01 0.253 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.585438e-01 0.253 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.624745e-01 0.250 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.624888e-01 0.250 0 0
Removal of the Flap Intermediate R-HSA-69166 5.640801e-01 0.249 0 0
Signal regulatory protein family interactions R-HSA-391160 5.640801e-01 0.249 0 0
GPER1 signaling R-HSA-9634597 5.650485e-01 0.248 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.715051e-01 0.243 0 0
Synthesis of DNA R-HSA-69239 5.721310e-01 0.243 0 0
Muscle contraction R-HSA-397014 5.828997e-01 0.234 0 0
Signaling by NODAL R-HSA-1181150 5.836436e-01 0.234 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.837427e-01 0.234 0 0
Gap junction degradation R-HSA-190873 5.837427e-01 0.234 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.837427e-01 0.234 0 0
ALK mutants bind TKIs R-HSA-9700645 5.837427e-01 0.234 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 5.837427e-01 0.234 0 0
Calcineurin activates NFAT R-HSA-2025928 5.837427e-01 0.234 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.837427e-01 0.234 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.837427e-01 0.234 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.837427e-01 0.234 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.837427e-01 0.234 0 0
Lipophagy R-HSA-9613354 5.837427e-01 0.234 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.837427e-01 0.234 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.837427e-01 0.234 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.837427e-01 0.234 0 0
Adaptive Immune System R-HSA-1280218 5.876688e-01 0.231 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.935597e-01 0.227 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.990388e-01 0.223 0 0
Ion homeostasis R-HSA-5578775 5.990388e-01 0.223 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.990388e-01 0.223 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.994874e-01 0.222 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.004239e-01 0.222 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.004239e-01 0.222 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.004239e-01 0.222 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.004239e-01 0.222 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.004239e-01 0.222 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.004239e-01 0.222 0 0
Translesion synthesis by REV1 R-HSA-110312 6.004239e-01 0.222 0 0
p75NTR signals via NF-kB R-HSA-193639 6.004239e-01 0.222 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.004239e-01 0.222 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.050841e-01 0.218 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.050860e-01 0.218 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.064815e-01 0.217 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.130608e-01 0.212 0 0
Cardiogenesis R-HSA-9733709 6.130608e-01 0.212 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.134043e-01 0.212 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.142023e-01 0.212 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.142023e-01 0.212 0 0
Lagging Strand Synthesis R-HSA-69186 6.142023e-01 0.212 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.142023e-01 0.212 0 0
Cyclin D associated events in G1 R-HSA-69231 6.150427e-01 0.211 0 0
G1 Phase R-HSA-69236 6.150427e-01 0.211 0 0
UCH proteinases R-HSA-5689603 6.154259e-01 0.211 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.218330e-01 0.206 0 0
Stabilization of p53 R-HSA-69541 6.250687e-01 0.204 0 0
Alternative complement activation R-HSA-173736 6.251548e-01 0.204 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 6.251548e-01 0.204 0 0
Nucleotide catabolism defects R-HSA-9735786 6.251548e-01 0.204 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 6.251548e-01 0.204 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 6.251548e-01 0.204 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 6.251548e-01 0.204 0 0
Signaling by MAP2K mutants R-HSA-9652169 6.251548e-01 0.204 0 0
TNFR1-mediated ceramide production R-HSA-5626978 6.251548e-01 0.204 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.251548e-01 0.204 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.251548e-01 0.204 0 0
ATP sensitive Potassium channels R-HSA-1296025 6.251548e-01 0.204 0 0
Sensory perception of sour taste R-HSA-9729555 6.251548e-01 0.204 0 0
NADE modulates death signalling R-HSA-205025 6.251548e-01 0.204 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 6.251548e-01 0.204 0 0
HSF1-dependent transactivation R-HSA-3371571 6.264406e-01 0.203 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.270468e-01 0.203 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.270468e-01 0.203 0 0
Arachidonate production from DAG R-HSA-426048 6.270468e-01 0.203 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.270468e-01 0.203 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 6.270468e-01 0.203 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.270468e-01 0.203 0 0
Signaling by Leptin R-HSA-2586552 6.270468e-01 0.203 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.295907e-01 0.201 0 0
Translesion synthesis by POLI R-HSA-5656121 6.347137e-01 0.197 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.347137e-01 0.197 0 0
Killing mechanisms R-HSA-9664420 6.347137e-01 0.197 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.347137e-01 0.197 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.347137e-01 0.197 0 0
Negative regulation of FLT3 R-HSA-9706369 6.347137e-01 0.197 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.347137e-01 0.197 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.359135e-01 0.197 0 0
Dual incision in TC-NER R-HSA-6782135 6.368716e-01 0.196 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.370801e-01 0.196 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.433262e-01 0.192 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.433262e-01 0.192 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.433262e-01 0.192 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 6.469806e-01 0.189 0 0
Attenuation phase R-HSA-3371568 6.469806e-01 0.189 0 0
PCP/CE pathway R-HSA-4086400 6.481406e-01 0.188 0 0
Telomere Extension By Telomerase R-HSA-171319 6.519053e-01 0.186 0 0
Developmental Cell Lineages R-HSA-9734767 6.522091e-01 0.186 0 0
Neutrophil degranulation R-HSA-6798695 6.572889e-01 0.182 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.601918e-01 0.180 0 0
Dual Incision in GG-NER R-HSA-5696400 6.601918e-01 0.180 0 0
Signaling by NOTCH2 R-HSA-1980145 6.601918e-01 0.180 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.601918e-01 0.180 0 0
Signal amplification R-HSA-392518 6.601918e-01 0.180 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.653297e-01 0.177 0 0
PI Metabolism R-HSA-1483255 6.666384e-01 0.176 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 6.667636e-01 0.176 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.667636e-01 0.176 0 0
Synthesis of PI R-HSA-1483226 6.667636e-01 0.176 0 0
Ionotropic activity of kainate receptors R-HSA-451306 6.667636e-01 0.176 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 6.667636e-01 0.176 0 0
Interleukin-2 signaling R-HSA-9020558 6.667636e-01 0.176 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.668951e-01 0.176 0 0
Translesion synthesis by POLK R-HSA-5655862 6.668951e-01 0.176 0 0
Fibronectin matrix formation R-HSA-1566977 6.668951e-01 0.176 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 6.709637e-01 0.173 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.709637e-01 0.173 0 0
Cellular hexose transport R-HSA-189200 6.709637e-01 0.173 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.709637e-01 0.173 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.727043e-01 0.172 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.727043e-01 0.172 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.727043e-01 0.172 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.727043e-01 0.172 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.727043e-01 0.172 0 0
mRNA Capping R-HSA-72086 6.764100e-01 0.170 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.764100e-01 0.170 0 0
DARPP-32 events R-HSA-180024 6.764100e-01 0.170 0 0
Platelet calcium homeostasis R-HSA-418360 6.764100e-01 0.170 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.794006e-01 0.168 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.817182e-01 0.166 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.817182e-01 0.166 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.817182e-01 0.166 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.817182e-01 0.166 0 0
Defective F9 activation R-HSA-9673221 6.817182e-01 0.166 0 0
Activation of C3 and C5 R-HSA-174577 6.817182e-01 0.166 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.817182e-01 0.166 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.817182e-01 0.166 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.817182e-01 0.166 0 0
PTK6 Down-Regulation R-HSA-8849472 6.817182e-01 0.166 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.817182e-01 0.166 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.817182e-01 0.166 0 0
Inositol transporters R-HSA-429593 6.817182e-01 0.166 0 0
Co-inhibition by BTLA R-HSA-9927353 6.817182e-01 0.166 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.817182e-01 0.166 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.817182e-01 0.166 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.817182e-01 0.166 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.829119e-01 0.166 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.846707e-01 0.165 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.884608e-01 0.162 0 0
PLC beta mediated events R-HSA-112043 6.898163e-01 0.161 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.933662e-01 0.159 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.934168e-01 0.159 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.938909e-01 0.159 0 0
Cellular response to chemical stress R-HSA-9711123 6.952563e-01 0.158 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.969538e-01 0.157 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.970867e-01 0.157 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.970867e-01 0.157 0 0
Carnitine shuttle R-HSA-200425 6.970867e-01 0.157 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.997373e-01 0.155 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.997373e-01 0.155 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.027633e-01 0.153 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.029895e-01 0.153 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.029895e-01 0.153 0 0
ERKs are inactivated R-HSA-202670 7.029895e-01 0.153 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.029895e-01 0.153 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.029895e-01 0.153 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.029895e-01 0.153 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.035677e-01 0.153 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.035677e-01 0.153 0 0
HSF1 activation R-HSA-3371511 7.035677e-01 0.153 0 0
Interferon alpha/beta signaling R-HSA-909733 7.061232e-01 0.151 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.070685e-01 0.151 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.223547e-01 0.141 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.229686e-01 0.141 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.237942e-01 0.140 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.249081e-01 0.140 0 0
PKA activation in glucagon signalling R-HSA-164378 7.249081e-01 0.140 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.249081e-01 0.140 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.249081e-01 0.140 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 7.249081e-01 0.140 0 0
Plus-strand DNA synthesis R-HSA-164525 7.297490e-01 0.137 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 7.297490e-01 0.137 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.297490e-01 0.137 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.297490e-01 0.137 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.297490e-01 0.137 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 7.297490e-01 0.137 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 7.297490e-01 0.137 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 7.297490e-01 0.137 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 7.297490e-01 0.137 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 7.297490e-01 0.137 0 0
PDE3B signalling R-HSA-165160 7.297490e-01 0.137 0 0
Synthesis of PS R-HSA-1483101 7.297490e-01 0.137 0 0
PKB-mediated events R-HSA-109703 7.297490e-01 0.137 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 7.297490e-01 0.137 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 7.297490e-01 0.137 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 7.297490e-01 0.137 0 0
VEGF ligand-receptor interactions R-HSA-194313 7.297490e-01 0.137 0 0
PI3K Cascade R-HSA-109704 7.300963e-01 0.137 0 0
Signaling by ROBO receptors R-HSA-376176 7.319451e-01 0.136 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.332462e-01 0.135 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.358736e-01 0.133 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.358736e-01 0.133 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.358736e-01 0.133 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.358736e-01 0.133 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.358736e-01 0.133 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.358736e-01 0.133 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.358736e-01 0.133 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.377609e-01 0.132 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.447723e-01 0.128 0 0
Tight junction interactions R-HSA-420029 7.447723e-01 0.128 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.447723e-01 0.128 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.447723e-01 0.128 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.447723e-01 0.128 0 0
Eukaryotic Translation Termination R-HSA-72764 7.457602e-01 0.127 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.457602e-01 0.127 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.495267e-01 0.125 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.498759e-01 0.125 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.508023e-01 0.124 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.508023e-01 0.124 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.508023e-01 0.124 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.508023e-01 0.124 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.508023e-01 0.124 0 0
Other interleukin signaling R-HSA-449836 7.508023e-01 0.124 0 0
SARS-CoV Infections R-HSA-9679506 7.558171e-01 0.122 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.558374e-01 0.122 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.612935e-01 0.118 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.615312e-01 0.118 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.615312e-01 0.118 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.625712e-01 0.118 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.645630e-01 0.117 0 0
Amino acid transport across the plasma membrane R-HSA-352230 7.645630e-01 0.117 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.655994e-01 0.116 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.655994e-01 0.116 0 0
Ca2+ pathway R-HSA-4086398 7.693669e-01 0.114 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.705340e-01 0.113 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.705340e-01 0.113 0 0
VLDL assembly R-HSA-8866423 7.705340e-01 0.113 0 0
Chylomicron clearance R-HSA-8964026 7.705340e-01 0.113 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.705340e-01 0.113 0 0
Uncoating of the HIV Virion R-HSA-162585 7.705340e-01 0.113 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.705340e-01 0.113 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 7.705340e-01 0.113 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.705340e-01 0.113 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.705340e-01 0.113 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.705340e-01 0.113 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 7.705340e-01 0.113 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.705340e-01 0.113 0 0
MET Receptor Activation R-HSA-6806942 7.705340e-01 0.113 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.705340e-01 0.113 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.705340e-01 0.113 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.705340e-01 0.113 0 0
Lactose synthesis R-HSA-5653890 7.705340e-01 0.113 0 0
NADPH regeneration R-HSA-389542 7.705340e-01 0.113 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.747013e-01 0.111 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.747013e-01 0.111 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.747013e-01 0.111 0 0
HCMV Late Events R-HSA-9610379 7.767497e-01 0.110 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.779499e-01 0.109 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.789490e-01 0.108 0 0
G-protein mediated events R-HSA-112040 7.804715e-01 0.108 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.811581e-01 0.107 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.860332e-01 0.105 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.865056e-01 0.104 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.865056e-01 0.104 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.923710e-01 0.101 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.923710e-01 0.101 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.923710e-01 0.101 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.923710e-01 0.101 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 7.923710e-01 0.101 0 0
cGMP effects R-HSA-418457 7.923710e-01 0.101 0 0
Physiological factors R-HSA-5578768 7.923710e-01 0.101 0 0
Zinc transporters R-HSA-435354 7.923710e-01 0.101 0 0
P2Y receptors R-HSA-417957 7.923710e-01 0.101 0 0
Parasitic Infection Pathways R-HSA-9824443 7.925661e-01 0.101 0 0
Leishmania infection R-HSA-9658195 7.925661e-01 0.101 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.930522e-01 0.101 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 7.935396e-01 0.100 0 0
Toll-like Receptor Cascades R-HSA-168898 7.946521e-01 0.100 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.966850e-01 0.099 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.966850e-01 0.099 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.966850e-01 0.099 0 0
Peptide chain elongation R-HSA-156902 7.982875e-01 0.098 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 8.051659e-01 0.094 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 8.051659e-01 0.094 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 8.051659e-01 0.094 0 0
LDL remodeling R-HSA-8964041 8.051659e-01 0.094 0 0
Ca2+ activated K+ channels R-HSA-1296052 8.051659e-01 0.094 0 0
Biosynthesis of maresin conjugates in tissue regeneration (MCTR) R-HSA-9026762 8.051659e-01 0.094 0 0
Netrin mediated repulsion signals R-HSA-418886 8.051659e-01 0.094 0 0
Insulin receptor recycling R-HSA-77387 8.052330e-01 0.094 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.052330e-01 0.094 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.052330e-01 0.094 0 0
Gluconeogenesis R-HSA-70263 8.075848e-01 0.093 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.164030e-01 0.088 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.164030e-01 0.088 0 0
Biotin transport and metabolism R-HSA-196780 8.164030e-01 0.088 0 0
Signaling by Activin R-HSA-1502540 8.164030e-01 0.088 0 0
DNA Damage Reversal R-HSA-73942 8.164030e-01 0.088 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.168445e-01 0.088 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.168445e-01 0.088 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.168445e-01 0.088 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.179492e-01 0.087 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.179492e-01 0.087 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.181859e-01 0.087 0 0
DNA Damage Bypass R-HSA-73893 8.213191e-01 0.085 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.213191e-01 0.085 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.213191e-01 0.085 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.237462e-01 0.084 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.249565e-01 0.084 0 0
ECM proteoglycans R-HSA-3000178 8.293067e-01 0.081 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.298973e-01 0.081 0 0
Ion transport by P-type ATPases R-HSA-936837 8.301049e-01 0.081 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.307469e-01 0.081 0 0
Signaling by Hedgehog R-HSA-5358351 8.330072e-01 0.079 0 0
Reverse Transcription of HIV RNA R-HSA-162589 8.345727e-01 0.079 0 0
Minus-strand DNA synthesis R-HSA-164516 8.345727e-01 0.079 0 0
phospho-PLA2 pathway R-HSA-111995 8.345727e-01 0.079 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 8.345727e-01 0.079 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.345727e-01 0.079 0 0
Fructose biosynthesis R-HSA-5652227 8.345727e-01 0.079 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 8.345727e-01 0.079 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.345727e-01 0.079 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.345727e-01 0.079 0 0
Sodium/Proton exchangers R-HSA-425986 8.345727e-01 0.079 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 8.345727e-01 0.079 0 0
Modulation by Mtb of host immune system R-HSA-9637628 8.345727e-01 0.079 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.352784e-01 0.078 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.352784e-01 0.078 0 0
LDL clearance R-HSA-8964038 8.352784e-01 0.078 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.379124e-01 0.077 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.379124e-01 0.077 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.379124e-01 0.077 0 0
Atorvastatin ADME R-HSA-9754706 8.379124e-01 0.077 0 0
Activation of SMO R-HSA-5635838 8.379124e-01 0.077 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.379124e-01 0.077 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.389002e-01 0.076 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.393395e-01 0.076 0 0
Opioid Signalling R-HSA-111885 8.408342e-01 0.075 0 0
Degradation of DVL R-HSA-4641258 8.443847e-01 0.073 0 0
RSV-host interactions R-HSA-9833110 8.494854e-01 0.071 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.534959e-01 0.069 0 0
Cargo concentration in the ER R-HSA-5694530 8.534959e-01 0.069 0 0
Regulation of beta-cell development R-HSA-186712 8.544302e-01 0.068 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.571131e-01 0.067 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.571131e-01 0.067 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.571131e-01 0.067 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.571131e-01 0.067 0 0
Galactose catabolism R-HSA-70370 8.571131e-01 0.067 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.571131e-01 0.067 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.571131e-01 0.067 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.581983e-01 0.066 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.595425e-01 0.066 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.595425e-01 0.066 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.595425e-01 0.066 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.595425e-01 0.066 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.595425e-01 0.066 0 0
Signaling by NOTCH4 R-HSA-9013694 8.601208e-01 0.065 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.620711e-01 0.064 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.628961e-01 0.064 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.628961e-01 0.064 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.628961e-01 0.064 0 0
Somitogenesis R-HSA-9824272 8.628961e-01 0.064 0 0
tRNA Aminoacylation R-HSA-379724 8.648464e-01 0.063 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.671491e-01 0.062 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.673830e-01 0.062 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.693500e-01 0.061 0 0
Gastrulation R-HSA-9758941 8.701715e-01 0.060 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.732803e-01 0.059 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.739794e-01 0.058 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.740628e-01 0.058 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.742119e-01 0.058 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.742119e-01 0.058 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.742119e-01 0.058 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.742119e-01 0.058 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.742119e-01 0.058 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.746487e-01 0.058 0 0
Transmission across Chemical Synapses R-HSA-112315 8.784650e-01 0.056 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.796937e-01 0.056 0 0
Binding and entry of HIV virion R-HSA-173107 8.807445e-01 0.055 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.807445e-01 0.055 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.807445e-01 0.055 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.807445e-01 0.055 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.807445e-01 0.055 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.807445e-01 0.055 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.812139e-01 0.055 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.812636e-01 0.055 0 0
Formation of the nephric duct R-HSA-9830364 8.812636e-01 0.055 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.812636e-01 0.055 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.838593e-01 0.054 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.882012e-01 0.051 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.883392e-01 0.051 0 0
Interleukin-1 family signaling R-HSA-446652 8.883392e-01 0.051 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.890163e-01 0.051 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.894057e-01 0.051 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.894057e-01 0.051 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.894057e-01 0.051 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.894057e-01 0.051 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.894057e-01 0.051 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 8.894057e-01 0.051 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.894057e-01 0.051 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.911963e-01 0.050 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.911963e-01 0.050 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.911963e-01 0.050 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.917118e-01 0.050 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.938347e-01 0.049 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.938347e-01 0.049 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.938347e-01 0.049 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.938347e-01 0.049 0 0
Urea cycle R-HSA-70635 8.938347e-01 0.049 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.970032e-01 0.047 0 0
Chylomicron assembly R-HSA-8963888 8.987471e-01 0.046 0 0
vRNA Synthesis R-HSA-192814 8.987471e-01 0.046 0 0
vRNP Assembly R-HSA-192905 8.987471e-01 0.046 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 8.987471e-01 0.046 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.987471e-01 0.046 0 0
Transport of RCbl within the body R-HSA-9758890 8.987471e-01 0.046 0 0
LGI-ADAM interactions R-HSA-5682910 8.987471e-01 0.046 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.987471e-01 0.046 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.987471e-01 0.046 0 0
Prostanoid ligand receptors R-HSA-391908 8.987471e-01 0.046 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.987471e-01 0.046 0 0
Sensory processing of sound R-HSA-9659379 9.014649e-01 0.045 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.028799e-01 0.044 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.028799e-01 0.044 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.028799e-01 0.044 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.028799e-01 0.044 0 0
The NLRP3 inflammasome R-HSA-844456 9.028799e-01 0.044 0 0
Specification of the neural plate border R-HSA-9834899 9.028799e-01 0.044 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.028799e-01 0.044 0 0
Diseases of hemostasis R-HSA-9671793 9.028799e-01 0.044 0 0
Cristae formation R-HSA-8949613 9.051968e-01 0.043 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.051968e-01 0.043 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.103237e-01 0.041 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.110687e-01 0.040 0 0
PERK regulates gene expression R-HSA-381042 9.113394e-01 0.040 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 9.140330e-01 0.039 0 0
DS-GAG biosynthesis R-HSA-2022923 9.140330e-01 0.039 0 0
Scavenging by Class H Receptors R-HSA-3000497 9.140330e-01 0.039 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 9.140330e-01 0.039 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 9.140330e-01 0.039 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 9.140330e-01 0.039 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 9.140330e-01 0.039 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 9.140330e-01 0.039 0 0
Anchoring fibril formation R-HSA-2214320 9.140330e-01 0.039 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.148074e-01 0.039 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.148074e-01 0.039 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.148074e-01 0.039 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.148074e-01 0.039 0 0
Protein hydroxylation R-HSA-9629569 9.148074e-01 0.039 0 0
Pyrimidine salvage R-HSA-73614 9.154465e-01 0.038 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.192511e-01 0.037 0 0
Peroxisomal protein import R-HSA-9033241 9.199568e-01 0.036 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.199568e-01 0.036 0 0
Interferon gamma signaling R-HSA-877300 9.229305e-01 0.035 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.241648e-01 0.034 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.242725e-01 0.034 0 0
Late endosomal microautophagy R-HSA-9615710 9.246762e-01 0.034 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.246762e-01 0.034 0 0
G-protein activation R-HSA-202040 9.253480e-01 0.034 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.253480e-01 0.034 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.253480e-01 0.034 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.253480e-01 0.034 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.257728e-01 0.033 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.257728e-01 0.033 0 0
Amine ligand-binding receptors R-HSA-375280 9.260686e-01 0.033 0 0
Maple Syrup Urine Disease R-HSA-9865114 9.270119e-01 0.033 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 9.270119e-01 0.033 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 9.270119e-01 0.033 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.270119e-01 0.033 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.270119e-01 0.033 0 0
Regulation of IFNG signaling R-HSA-877312 9.270119e-01 0.033 0 0
OAS antiviral response R-HSA-8983711 9.270119e-01 0.033 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.321088e-01 0.031 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.322891e-01 0.030 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.322891e-01 0.030 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.326705e-01 0.030 0 0
Aquaporin-mediated transport R-HSA-445717 9.326705e-01 0.030 0 0
Assembly Of The HIV Virion R-HSA-175474 9.346485e-01 0.029 0 0
Serine metabolism R-HSA-977347 9.346485e-01 0.029 0 0
PPARA activates gene expression R-HSA-1989781 9.351546e-01 0.029 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.351741e-01 0.029 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.353468e-01 0.029 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.353468e-01 0.029 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.353468e-01 0.029 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.380320e-01 0.028 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.380320e-01 0.028 0 0
Chylomicron remodeling R-HSA-8963901 9.380320e-01 0.028 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.380320e-01 0.028 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.380320e-01 0.028 0 0
Interconversion of polyamines R-HSA-351200 9.380320e-01 0.028 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.380320e-01 0.028 0 0
Maturation of nucleoprotein R-HSA-9683610 9.380320e-01 0.028 0 0
Interleukin-6 signaling R-HSA-1059683 9.380320e-01 0.028 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.380320e-01 0.028 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.382938e-01 0.028 0 0
COPII-mediated vesicle transport R-HSA-204005 9.390756e-01 0.027 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.393059e-01 0.027 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.393059e-01 0.027 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.404203e-01 0.027 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.404203e-01 0.027 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.419315e-01 0.026 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.419315e-01 0.026 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.422596e-01 0.026 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.428430e-01 0.026 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.428430e-01 0.026 0 0
Fructose metabolism R-HSA-5652084 9.428430e-01 0.026 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.428430e-01 0.026 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.428430e-01 0.026 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.440234e-01 0.025 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.440234e-01 0.025 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.450900e-01 0.025 0 0
Cellular response to starvation R-HSA-9711097 9.455570e-01 0.024 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.470940e-01 0.024 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.470940e-01 0.024 0 0
Platelet homeostasis R-HSA-418346 9.472728e-01 0.024 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.473887e-01 0.023 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 9.473887e-01 0.023 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.473887e-01 0.023 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.473887e-01 0.023 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.473887e-01 0.023 0 0
Hydrolysis of LPC R-HSA-1483115 9.473887e-01 0.023 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 9.473887e-01 0.023 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 9.473887e-01 0.023 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 9.473887e-01 0.023 0 0
HDL assembly R-HSA-8963896 9.473887e-01 0.023 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.473887e-01 0.023 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.473887e-01 0.023 0 0
Ribosome-associated quality control R-HSA-9948299 9.477415e-01 0.023 0 0
Viral Infection Pathways R-HSA-9824446 9.478813e-01 0.023 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.478986e-01 0.023 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.478986e-01 0.023 0 0
Diseases of Immune System R-HSA-5260271 9.478986e-01 0.023 0 0
TNF signaling R-HSA-75893 9.488981e-01 0.023 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.488981e-01 0.023 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.493340e-01 0.023 0 0
Formation of the ureteric bud R-HSA-9830674 9.500535e-01 0.022 0 0
Interleukin-20 family signaling R-HSA-8854691 9.500535e-01 0.022 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.500535e-01 0.022 0 0
Metal ion SLC transporters R-HSA-425410 9.503710e-01 0.022 0 0
Interleukin-1 signaling R-HSA-9020702 9.528886e-01 0.021 0 0
Selenocysteine synthesis R-HSA-2408557 9.528886e-01 0.021 0 0
Recycling of bile acids and salts R-HSA-159418 9.530662e-01 0.021 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.553331e-01 0.020 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.553331e-01 0.020 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.553331e-01 0.020 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.553331e-01 0.020 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 9.553331e-01 0.020 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 9.553331e-01 0.020 0 0
Transport and metabolism of PAPS R-HSA-174362 9.553331e-01 0.020 0 0
Protein methylation R-HSA-8876725 9.553331e-01 0.020 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.563902e-01 0.019 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.563902e-01 0.019 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.581783e-01 0.019 0 0
Viral mRNA Translation R-HSA-192823 9.594916e-01 0.018 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.605774e-01 0.017 0 0
tRNA processing R-HSA-72306 9.615134e-01 0.017 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.619525e-01 0.017 0 0
G protein gated Potassium channels R-HSA-1296059 9.619525e-01 0.017 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.619525e-01 0.017 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.619525e-01 0.017 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.619525e-01 0.017 0 0
Laminin interactions R-HSA-3000157 9.619525e-01 0.017 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.620783e-01 0.017 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.620783e-01 0.017 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.620783e-01 0.017 0 0
Fructose catabolism R-HSA-70350 9.620783e-01 0.017 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.620783e-01 0.017 0 0
Differentiation of T cells R-HSA-9945266 9.620783e-01 0.017 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.625827e-01 0.017 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.631669e-01 0.016 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.631669e-01 0.016 0 0
eNOS activation R-HSA-203615 9.631669e-01 0.016 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.631669e-01 0.016 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.631669e-01 0.016 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.635596e-01 0.016 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.665531e-01 0.015 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.668298e-01 0.015 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.674131e-01 0.014 0 0
Regulation of Apoptosis R-HSA-169911 9.674131e-01 0.014 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.678052e-01 0.014 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.678052e-01 0.014 0 0
Heme assimilation R-HSA-9927020 9.678052e-01 0.014 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.678052e-01 0.014 0 0
Passive transport by Aquaporins R-HSA-432047 9.678052e-01 0.014 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.678052e-01 0.014 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.678052e-01 0.014 0 0
Synthesis of PG R-HSA-1483148 9.678052e-01 0.014 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.678052e-01 0.014 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.678052e-01 0.014 0 0
Immune System R-HSA-168256 9.697279e-01 0.013 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.701954e-01 0.013 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.711021e-01 0.013 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.711021e-01 0.013 0 0
Insulin processing R-HSA-264876 9.711021e-01 0.013 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.711939e-01 0.013 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.726675e-01 0.012 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.726675e-01 0.012 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.726675e-01 0.012 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.726675e-01 0.012 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.745564e-01 0.011 0 0
Degradation of AXIN R-HSA-4641257 9.745564e-01 0.011 0 0
Collagen chain trimerization R-HSA-8948216 9.745564e-01 0.011 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.748408e-01 0.011 0 0
Inflammasomes R-HSA-622312 9.748408e-01 0.011 0 0
Pyroptosis R-HSA-5620971 9.748408e-01 0.011 0 0
G alpha (z) signalling events R-HSA-418597 9.761497e-01 0.010 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.762311e-01 0.010 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.762311e-01 0.010 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.762311e-01 0.010 0 0
Nephron development R-HSA-9831926 9.767957e-01 0.010 0 0
Biosynthesis of DHA-derived sulfido conjugates R-HSA-9026395 9.767957e-01 0.010 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.767957e-01 0.010 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.769167e-01 0.010 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.773146e-01 0.010 0 0
Elastic fibre formation R-HSA-1566948 9.775437e-01 0.010 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.781097e-01 0.010 0 0
Glucagon-type ligand receptors R-HSA-420092 9.781097e-01 0.010 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.783482e-01 0.010 0 0
Cellular response to hypoxia R-HSA-1234174 9.790387e-01 0.009 0 0
RAS processing R-HSA-9648002 9.801951e-01 0.009 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.801951e-01 0.009 0 0
Pyrimidine biosynthesis R-HSA-500753 9.803006e-01 0.009 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.803006e-01 0.009 0 0
Maturation of nucleoprotein R-HSA-9694631 9.803006e-01 0.009 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.803006e-01 0.009 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.809653e-01 0.008 0 0
Glycogen metabolism R-HSA-8982491 9.825459e-01 0.008 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.832762e-01 0.007 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.832762e-01 0.007 0 0
Creatine metabolism R-HSA-71288 9.832762e-01 0.007 0 0
Pregnenolone biosynthesis R-HSA-196108 9.832762e-01 0.007 0 0
Glycogen synthesis R-HSA-3322077 9.832762e-01 0.007 0 0
Budding and maturation of HIV virion R-HSA-162588 9.834579e-01 0.007 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.846283e-01 0.007 0 0
Regulated Necrosis R-HSA-5218859 9.846407e-01 0.007 0 0
Neuronal System R-HSA-112316 9.847797e-01 0.007 0 0
Azathioprine ADME R-HSA-9748787 9.850898e-01 0.007 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.858026e-01 0.006 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.858026e-01 0.006 0 0
ABC-family proteins mediated transport R-HSA-382556 9.860615e-01 0.006 0 0
FCGR activation R-HSA-2029481 9.864401e-01 0.006 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.864713e-01 0.006 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.864713e-01 0.006 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.867544e-01 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.875268e-01 0.005 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.877797e-01 0.005 0 0
CS-GAG biosynthesis R-HSA-2022870 9.879474e-01 0.005 0 0
Attachment and Entry R-HSA-9694614 9.879474e-01 0.005 0 0
Ribavirin ADME R-HSA-9755088 9.879474e-01 0.005 0 0
Integration of energy metabolism R-HSA-163685 9.880053e-01 0.005 0 0
Activation of GABAB receptors R-HSA-991365 9.881010e-01 0.005 0 0
GABA B receptor activation R-HSA-977444 9.881010e-01 0.005 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.882134e-01 0.005 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.882134e-01 0.005 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.882411e-01 0.005 0 0
Mitochondrial protein import R-HSA-1268020 9.889688e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.891772e-01 0.005 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.891772e-01 0.005 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.895409e-01 0.005 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.895678e-01 0.005 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.897683e-01 0.004 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.897683e-01 0.004 0 0
Free fatty acid receptors R-HSA-444209 9.897683e-01 0.004 0 0
Ethanol oxidation R-HSA-71384 9.897683e-01 0.004 0 0
Protein localization R-HSA-9609507 9.899707e-01 0.004 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.906137e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.906137e-01 0.004 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.906958e-01 0.004 0 0
Proteasome assembly R-HSA-9907900 9.908121e-01 0.004 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.913142e-01 0.004 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.913142e-01 0.004 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.913142e-01 0.004 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.913142e-01 0.004 0 0
Biosynthesis of maresins R-HSA-9018682 9.913142e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.918047e-01 0.004 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.918634e-01 0.004 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.918634e-01 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.918634e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.918634e-01 0.004 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.919335e-01 0.004 0 0
Selenoamino acid metabolism R-HSA-2408522 9.921359e-01 0.003 0 0
Complex III assembly R-HSA-9865881 9.926266e-01 0.003 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.926266e-01 0.003 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.926266e-01 0.003 0 0
Interleukin-6 family signaling R-HSA-6783589 9.926266e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.929497e-01 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 9.929497e-01 0.003 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.929497e-01 0.003 0 0
Triglyceride catabolism R-HSA-163560 9.929497e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.930040e-01 0.003 0 0
Hyaluronan degradation R-HSA-2160916 9.937407e-01 0.003 0 0
Kidney development R-HSA-9830369 9.937663e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.938936e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.938936e-01 0.003 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.943194e-01 0.002 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.946866e-01 0.002 0 0
TRP channels R-HSA-3295583 9.946866e-01 0.002 0 0
Sphingolipid catabolism R-HSA-9845614 9.946866e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.946919e-01 0.002 0 0
Purine salvage R-HSA-74217 9.947133e-01 0.002 0 0
Cardiac conduction R-HSA-5576891 9.948543e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.952337e-01 0.002 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.952337e-01 0.002 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.954248e-01 0.002 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.954248e-01 0.002 0 0
Pentose phosphate pathway R-HSA-71336 9.954248e-01 0.002 0 0
Triglyceride biosynthesis R-HSA-75109 9.954896e-01 0.002 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.954896e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.955634e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.955634e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.960823e-01 0.002 0 0
Hedgehog 'on' state R-HSA-5632684 9.960929e-01 0.002 0 0
ER-Phagosome pathway R-HSA-1236974 9.961347e-01 0.002 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.961712e-01 0.002 0 0
Prednisone ADME R-HSA-9757110 9.961712e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.963474e-01 0.002 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.963474e-01 0.002 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.964348e-01 0.002 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.965772e-01 0.001 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.965772e-01 0.001 0 0
SLC transporter disorders R-HSA-5619102 9.967190e-01 0.001 0 0
Thyroxine biosynthesis R-HSA-209968 9.967499e-01 0.001 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.967499e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.968349e-01 0.001 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.970411e-01 0.001 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.970411e-01 0.001 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.970411e-01 0.001 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.972412e-01 0.001 0 0
Neurotransmitter clearance R-HSA-112311 9.972412e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.973107e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.975515e-01 0.001 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.976582e-01 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.978873e-01 0.001 0 0
Translation R-HSA-72766 9.979471e-01 0.001 0 0
HS-GAG degradation R-HSA-2024096 9.980122e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.980922e-01 0.001 0 0
Methylation R-HSA-156581 9.980922e-01 0.001 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.980922e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.983093e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.983093e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.983093e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.983233e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.983529e-01 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.983529e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.983739e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.983739e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.983824e-01 0.001 0 0
CS/DS degradation R-HSA-2024101 9.985678e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.985678e-01 0.001 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.985678e-01 0.001 0 0
Heme degradation R-HSA-189483 9.985678e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.987489e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.987624e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.987734e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.987843e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.987843e-01 0.001 0 0
Retinoid metabolism and transport R-HSA-975634 9.989003e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.989003e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.989210e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.989781e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.990278e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.990595e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.990595e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.991516e-01 0.000 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.992566e-01 0.000 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.992566e-01 0.000 0 0
Metabolism of folate and pterines R-HSA-196757 9.992566e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.992705e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.993467e-01 0.000 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.993690e-01 0.000 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.993690e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.994966e-01 0.000 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.995454e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.995454e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.995454e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.995585e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.995593e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.995802e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.996142e-01 0.000 0 0
Maturation of spike protein R-HSA-9694548 9.996142e-01 0.000 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.996142e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.996428e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.996440e-01 0.000 0 0
Translation of Structural Proteins R-HSA-9683701 9.996726e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.996875e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.996998e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.997038e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.997641e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.997641e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.997700e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.997951e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.997951e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997971e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.997971e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.997976e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.997998e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.998237e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998295e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.998558e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.998674e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.998776e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.998859e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.998961e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999005e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999037e-01 0.000 0 0
Stimuli-sensing channels R-HSA-2672351 9.999079e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.999119e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.999229e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999229e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999229e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.999252e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.999365e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.999365e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.999365e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999389e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999389e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999561e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.999577e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.999612e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999634e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999667e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.999671e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999721e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999742e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999772e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999790e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999820e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999830e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999832e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999853e-01 0.000 0 0
Translation of Structural Proteins R-HSA-9694635 9.999867e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999903e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999909e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999919e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999928e-01 0.000 0 0
Neddylation R-HSA-8951664 9.999929e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999947e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999952e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999954e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999961e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999971e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999972e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999975e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999976e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.999976e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.999979e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999983e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999983e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999988e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.999990e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999992e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999994e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999994e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999996e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999997e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999997e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999998e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999998e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999998e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Signaling by BMP R-HSA-201451 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Apoptotic cleavage of cellular proteins R-HSA-111465 4.434064e-11 10.353 0 0
Apoptotic execution phase R-HSA-75153 9.387658e-10 9.027 0 0
Apoptosis R-HSA-109581 3.975322e-09 8.401 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 8.881799e-09 8.051 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.280185e-08 7.369 0 0
Programmed Cell Death R-HSA-5357801 5.303670e-08 7.275 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.180914e-05 4.928 0 0
mRNA Splicing R-HSA-72172 1.811595e-05 4.742 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.075819e-05 4.683 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.075819e-05 4.683 0 0
Formation of the cornified envelope R-HSA-6809371 2.087838e-05 4.680 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.943423e-04 3.711 0 0
EPH-Ephrin signaling R-HSA-2682334 2.140552e-04 3.669 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.263919e-04 3.645 0 0
Activation of BH3-only proteins R-HSA-114452 2.402809e-04 3.619 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 5.221362e-04 3.282 0 0
Cell-Cell communication R-HSA-1500931 4.842023e-04 3.315 0 0
Keratinization R-HSA-6805567 5.941544e-04 3.226 0 0
Signaling by Hippo R-HSA-2028269 8.375375e-04 3.077 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.457331e-04 3.024 0 0
Ephrin signaling R-HSA-3928664 9.513305e-04 3.022 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.161504e-03 2.935 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.162268e-03 2.935 0 0
Developmental Biology R-HSA-1266738 1.178562e-03 2.929 0 0
Signal Transduction R-HSA-162582 1.128559e-03 2.947 1 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.573519e-03 2.803 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.840061e-03 2.735 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.012653e-03 2.696 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.029619e-03 2.519 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.376718e-03 2.472 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.502166e-03 2.347 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.502166e-03 2.347 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.502166e-03 2.347 0 0
ESR-mediated signaling R-HSA-8939211 5.507232e-03 2.259 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.518624e-03 2.258 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 6.062877e-03 2.217 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.834878e-03 2.106 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.455522e-03 2.128 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.834878e-03 2.106 0 0
SARS-CoV Infections R-HSA-9679506 8.062613e-03 2.094 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.797862e-03 2.056 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.797862e-03 2.056 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.099248e-03 2.041 0 0
Signal regulatory protein family interactions R-HSA-391160 9.810991e-03 2.008 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.024643e-02 1.989 0 0
Metabolism of RNA R-HSA-8953854 1.081634e-02 1.966 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.087339e-02 1.964 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.198421e-02 1.921 0 0
Cell junction organization R-HSA-446728 1.181825e-02 1.927 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.399839e-02 1.854 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.417436e-02 1.848 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.434770e-02 1.843 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.632556e-02 1.787 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.691635e-02 1.772 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.823517e-02 1.739 0 0
TCR signaling R-HSA-202403 1.852683e-02 1.732 0 0
Signaling by ERBB2 R-HSA-1227986 1.884572e-02 1.725 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.163369e-02 1.665 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.218062e-02 1.654 0 0
FGFR2 alternative splicing R-HSA-6803529 2.251397e-02 1.648 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.402355e-02 1.619 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.402355e-02 1.619 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.429401e-02 1.615 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.226113e-02 1.491 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 3.226113e-02 1.491 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 3.226113e-02 1.491 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.226113e-02 1.491 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 3.226113e-02 1.491 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.226113e-02 1.491 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.226113e-02 1.491 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.226113e-02 1.491 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.226113e-02 1.491 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.226113e-02 1.491 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.226113e-02 1.491 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.226113e-02 1.491 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.226113e-02 1.491 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.226113e-02 1.491 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.045825e-02 1.516 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.879160e-02 1.541 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.045825e-02 1.516 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.952341e-02 1.530 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.879160e-02 1.541 0 0
Signaling by VEGF R-HSA-194138 2.875690e-02 1.541 0 0
Myogenesis R-HSA-525793 2.879160e-02 1.541 0 0
Formation of the nephric duct R-HSA-9830364 2.716311e-02 1.566 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.771113e-02 1.557 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.296758e-02 1.482 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.300369e-02 1.481 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.390316e-02 1.470 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.749218e-02 1.426 0 0
Integrin signaling R-HSA-354192 4.121980e-02 1.385 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.121980e-02 1.385 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.906825e-02 1.408 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.637018e-02 1.439 0 0
PTEN Regulation R-HSA-6807070 4.019319e-02 1.396 0 0
G-protein beta:gamma signalling R-HSA-397795 4.121980e-02 1.385 0 0
Signaling by Interleukins R-HSA-449147 4.045544e-02 1.393 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.518811e-02 1.454 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.800219e-02 1.319 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.800219e-02 1.319 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.508062e-02 1.346 0 0
Regulation of gap junction activity R-HSA-191650 4.800219e-02 1.319 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.422764e-02 1.354 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.800219e-02 1.319 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.800219e-02 1.319 0 0
Neurotransmitter release cycle R-HSA-112310 4.855721e-02 1.314 0 0
NADE modulates death signalling R-HSA-205025 4.800219e-02 1.319 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.111018e-02 1.291 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.278563e-02 1.369 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.705934e-02 1.327 0 0
Viral Infection Pathways R-HSA-9824446 4.962928e-02 1.304 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.705934e-02 1.327 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.508062e-02 1.346 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.906940e-02 1.309 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.113946e-02 1.291 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.318103e-02 1.274 0 0
Death Receptor Signaling R-HSA-73887 5.387577e-02 1.269 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.387577e-02 1.269 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.528135e-02 1.257 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.577717e-02 1.254 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.577717e-02 1.254 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.577717e-02 1.254 0 0
Activation of AKT2 R-HSA-165158 5.577717e-02 1.254 0 0
Diseases of Immune System R-HSA-5260271 5.741053e-02 1.241 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.741053e-02 1.241 0 0
Generation of second messenger molecules R-HSA-202433 5.741053e-02 1.241 0 0
NGF-independant TRKA activation R-HSA-187024 6.348912e-02 1.197 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.348912e-02 1.197 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.348912e-02 1.197 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.113856e-02 1.148 0 0
Chylomicron clearance R-HSA-8964026 7.113856e-02 1.148 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.872598e-02 1.104 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.872598e-02 1.104 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.396518e-02 1.194 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.872598e-02 1.104 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.075827e-02 1.150 0 0
Synthesis of PS R-HSA-1483101 6.348912e-02 1.197 0 0
PDE3B signalling R-HSA-165160 6.348912e-02 1.197 0 0
PKB-mediated events R-HSA-109703 6.348912e-02 1.197 0 0
Activation of TRKA receptors R-HSA-187015 7.872598e-02 1.104 0 0
Co-stimulation by CD28 R-HSA-389356 7.777455e-02 1.109 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.348912e-02 1.197 0 0
Cell-cell junction organization R-HSA-421270 7.317192e-02 1.136 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.348912e-02 1.197 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.348912e-02 1.197 0 0
CHL1 interactions R-HSA-447041 7.872598e-02 1.104 0 0
RSV-host interactions R-HSA-9833110 7.082721e-02 1.150 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.985058e-02 1.223 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.251379e-02 1.204 0 0
FOXO-mediated transcription R-HSA-9614085 6.251379e-02 1.204 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.777455e-02 1.109 0 0
FLT3 Signaling R-HSA-9607240 5.956795e-02 1.225 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 8.625190e-02 1.064 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.625190e-02 1.064 0 0
Type I hemidesmosome assembly R-HSA-446107 8.625190e-02 1.064 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.625190e-02 1.064 0 0
Lipophagy R-HSA-9613354 9.371680e-02 1.028 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.011212e-01 0.995 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.157503e-01 0.936 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.229760e-01 0.910 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 1.229760e-01 0.910 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 1.229760e-01 0.910 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.301431e-01 0.886 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.301431e-01 0.886 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.443033e-01 0.841 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 1.512974e-01 0.820 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 1.512974e-01 0.820 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 1.582348e-01 0.801 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 1.582348e-01 0.801 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 1.651159e-01 0.782 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 1.651159e-01 0.782 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.787110e-01 0.748 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 1.920865e-01 0.717 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 1.986929e-01 0.702 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.117453e-01 0.674 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.117453e-01 0.674 0 0
Termination of O-glycan biosynthesis R-HSA-977068 2.117453e-01 0.674 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 2.181921e-01 0.661 0 0
MET activates PTK2 signaling R-HSA-8874081 2.309293e-01 0.637 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.372204e-01 0.625 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.372204e-01 0.625 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.372204e-01 0.625 0 0
Nephrin family interactions R-HSA-373753 1.854260e-01 0.732 0 0
DCC mediated attractive signaling R-HSA-418885 1.443033e-01 0.841 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.625190e-02 1.064 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.833501e-01 0.737 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.854260e-01 0.732 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.402951e-01 0.853 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.309293e-01 0.637 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.372204e-01 0.625 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.370521e-01 0.625 0 0
Syndecan interactions R-HSA-3000170 2.117453e-01 0.674 0 0
Regulation of CDH11 function R-HSA-9762292 1.011212e-01 0.995 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.157503e-01 0.936 0 0
NF-kB is activated and signals survival R-HSA-209560 1.157503e-01 0.936 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.229760e-01 0.910 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.719412e-01 0.765 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 1.787110e-01 0.748 0 0
Neutrophil degranulation R-HSA-6798695 1.997079e-01 0.700 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.719412e-01 0.765 0 0
Attachment and Entry R-HSA-9694614 1.986929e-01 0.702 0 0
LDL clearance R-HSA-8964038 2.052457e-01 0.688 0 0
GP1b-IX-V activation signalling R-HSA-430116 9.371680e-02 1.028 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.719412e-01 0.765 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.745766e-01 0.758 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.052457e-01 0.688 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 1.920865e-01 0.717 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.920865e-01 0.717 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 2.181921e-01 0.661 0 0
Tight junction interactions R-HSA-420029 2.245867e-01 0.649 0 0
Axon guidance R-HSA-422475 9.477255e-02 1.023 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.181921e-01 0.661 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.172564e-01 0.931 0 0
Rap1 signalling R-HSA-392517 1.787110e-01 0.748 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 2.372204e-01 0.625 0 0
Nervous system development R-HSA-9675108 1.234460e-01 0.909 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.180887e-01 0.928 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.719412e-01 0.765 0 0
Bicarbonate transporters R-HSA-425381 1.084655e-01 0.965 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.229760e-01 0.910 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.443033e-01 0.841 0 0
Deadenylation of mRNA R-HSA-429947 2.181921e-01 0.661 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.181921e-01 0.661 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.686782e-02 1.014 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.686782e-02 1.014 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.018188e-01 0.992 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.018188e-01 0.992 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.572548e-01 0.803 0 0
Adherens junctions interactions R-HSA-418990 1.327522e-01 0.877 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.773198e-01 0.751 0 0
Autophagy R-HSA-9612973 1.721311e-01 0.764 0 0
RNA Polymerase II Transcription R-HSA-73857 1.647869e-01 0.783 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 9.371680e-02 1.028 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.512974e-01 0.820 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.487249e-01 0.828 0 0
Gene expression (Transcription) R-HSA-74160 8.879522e-02 1.052 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.316653e-01 0.881 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.563051e-01 0.806 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 1.229760e-01 0.910 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.512974e-01 0.820 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.719412e-01 0.765 0 0
Generic Transcription Pathway R-HSA-212436 2.174374e-01 0.663 0 0
Membrane Trafficking R-HSA-199991 9.977106e-02 1.001 0 0
p75NTR signals via NF-kB R-HSA-193639 1.443033e-01 0.841 0 0
Macroautophagy R-HSA-1632852 1.409723e-01 0.851 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 1.372520e-01 0.862 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 1.787110e-01 0.748 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.854260e-01 0.732 0 0
ERK/MAPK targets R-HSA-198753 1.920865e-01 0.717 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.986929e-01 0.702 0 0
Formation of the ureteric bud R-HSA-9830674 2.117453e-01 0.674 0 0
Retinoid metabolism and transport R-HSA-975634 1.375091e-01 0.862 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 1.854260e-01 0.732 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 1.787110e-01 0.748 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.245867e-01 0.649 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 1.658752e-01 0.780 0 0
Other interleukin signaling R-HSA-449836 1.787110e-01 0.748 0 0
HDMs demethylate histones R-HSA-3214842 2.245867e-01 0.649 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.430933e-01 0.844 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.402951e-01 0.853 0 0
Transport of RCbl within the body R-HSA-9758890 1.084655e-01 0.965 0 0
Protein methylation R-HSA-8876725 1.443033e-01 0.841 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.787110e-01 0.748 0 0
Adaptive Immune System R-HSA-1280218 9.912086e-02 1.004 0 0
Selective autophagy R-HSA-9663891 1.892349e-01 0.723 0 0
Signaling by FGFR in disease R-HSA-1226099 1.459034e-01 0.836 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.443033e-01 0.841 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.245867e-01 0.649 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.245867e-01 0.649 0 0
Ub-specific processing proteases R-HSA-5689880 2.092491e-01 0.679 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.309293e-01 0.637 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.524010e-02 1.021 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.719412e-01 0.765 0 0
GAB1 signalosome R-HSA-180292 1.719412e-01 0.765 0 0
S Phase R-HSA-69242 1.563051e-01 0.806 0 0
Signaling by FGFR2 R-HSA-5654738 1.629923e-01 0.788 0 0
Rab regulation of trafficking R-HSA-9007101 9.362385e-02 1.029 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.459034e-01 0.836 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 1.025900e-01 0.989 0 0
Kidney development R-HSA-9830369 1.264956e-01 0.898 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.245867e-01 0.649 0 0
PKR-mediated signaling R-HSA-9833482 1.629923e-01 0.788 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.052457e-01 0.688 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.745149e-02 1.058 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.245867e-01 0.649 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.512974e-01 0.820 0 0
Differentiation of T cells R-HSA-9945266 1.512974e-01 0.820 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 1.402951e-01 0.853 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.402951e-01 0.853 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.347358e-01 0.871 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.057901e-01 0.976 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.181921e-01 0.661 0 0
Neurodegenerative Diseases R-HSA-8863678 2.181921e-01 0.661 0 0
Immune System R-HSA-168256 1.011991e-01 0.995 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.745149e-02 1.058 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.250054e-01 0.648 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.638290e-02 1.016 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.250054e-01 0.648 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.250054e-01 0.648 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.372204e-01 0.625 0 0
Regulation of beta-cell development R-HSA-186712 1.051795e-01 0.978 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 1.719412e-01 0.765 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 2.052457e-01 0.688 0 0
Signaling by FGFR R-HSA-190236 2.250054e-01 0.648 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.210727e-01 0.917 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.686782e-02 1.014 0 0
Cellular response to chemical stress R-HSA-9711123 2.119199e-01 0.674 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.256311e-01 0.901 0 0
Interleukin-12 signaling R-HSA-9020591 1.515576e-01 0.819 0 0
Interleukin-12 family signaling R-HSA-447115 1.862891e-01 0.730 0 0
Vesicle-mediated transport R-HSA-5653656 2.405666e-01 0.619 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.430895e-01 0.614 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.430895e-01 0.614 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.434605e-01 0.614 0 0
HIV elongation arrest and recovery R-HSA-167287 2.434605e-01 0.614 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.434605e-01 0.614 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.434605e-01 0.614 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.434605e-01 0.614 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.434605e-01 0.614 0 0
Toll-like Receptor Cascades R-HSA-168898 2.479507e-01 0.606 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.485028e-01 0.605 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.491336e-01 0.604 0 0
Cell Cycle R-HSA-1640170 2.493775e-01 0.603 0 0
Late endosomal microautophagy R-HSA-9615710 2.496498e-01 0.603 0 0
mRNA Capping R-HSA-72086 2.496498e-01 0.603 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.496498e-01 0.603 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.496498e-01 0.603 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.496498e-01 0.603 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.496498e-01 0.603 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.551829e-01 0.593 0 0
Signaling by ALK in cancer R-HSA-9700206 2.551829e-01 0.593 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.557890e-01 0.592 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 2.557890e-01 0.592 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.582088e-01 0.588 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.582088e-01 0.588 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.610004e-01 0.583 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.612353e-01 0.583 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.642623e-01 0.578 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.642623e-01 0.578 0 0
HS-GAG degradation R-HSA-2024096 2.679181e-01 0.572 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.733434e-01 0.563 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.739089e-01 0.562 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.739089e-01 0.562 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.739089e-01 0.562 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.763699e-01 0.559 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.798510e-01 0.553 0 0
Heme degradation R-HSA-189483 2.798510e-01 0.553 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.824209e-01 0.549 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.857449e-01 0.544 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 2.857449e-01 0.544 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.857449e-01 0.544 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 2.857449e-01 0.544 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 2.857449e-01 0.544 0 0
Mitophagy R-HSA-5205647 2.857449e-01 0.544 0 0
L1CAM interactions R-HSA-373760 2.884679e-01 0.540 0 0
RET signaling R-HSA-8853659 2.973893e-01 0.527 0 0
HS-GAG biosynthesis R-HSA-2022928 2.973893e-01 0.527 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.973893e-01 0.527 0 0
FLT3 signaling in disease R-HSA-9682385 2.973893e-01 0.527 0 0
HSF1 activation R-HSA-3371511 2.973893e-01 0.527 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.973893e-01 0.527 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 2.973893e-01 0.527 0 0
FGFR2 mutant receptor activation R-HSA-1839126 2.973893e-01 0.527 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.031407e-01 0.518 0 0
SLC-mediated transport of organic cations R-HSA-549127 3.031407e-01 0.518 0 0
Cellular response to heat stress R-HSA-3371556 3.035588e-01 0.518 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.035588e-01 0.518 0 0
MET promotes cell motility R-HSA-8875878 3.088454e-01 0.510 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.101924e-01 0.508 0 0
Transmission across Chemical Synapses R-HSA-112315 3.101924e-01 0.508 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.145037e-01 0.502 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.145037e-01 0.502 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.145037e-01 0.502 0 0
G1/S Transition R-HSA-69206 3.185946e-01 0.497 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.201161e-01 0.495 0 0
HIV Transcription Elongation R-HSA-167169 3.201161e-01 0.495 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.201161e-01 0.495 0 0
Attenuation phase R-HSA-3371568 3.201161e-01 0.495 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.201161e-01 0.495 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.201161e-01 0.495 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.201161e-01 0.495 0 0
G2/M Checkpoints R-HSA-69481 3.245889e-01 0.489 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.256828e-01 0.487 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.256828e-01 0.487 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.256828e-01 0.487 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.275813e-01 0.485 0 0
Infectious disease R-HSA-5663205 3.283296e-01 0.484 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.312043e-01 0.480 0 0
HIV Transcription Initiation R-HSA-167161 3.312043e-01 0.480 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.312043e-01 0.480 0 0
MAP2K and MAPK activation R-HSA-5674135 3.312043e-01 0.480 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.312043e-01 0.480 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.312043e-01 0.480 0 0
MTOR signalling R-HSA-165159 3.366809e-01 0.473 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.366809e-01 0.473 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.421130e-01 0.466 0 0
Netrin-1 signaling R-HSA-373752 3.475010e-01 0.459 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 3.475010e-01 0.459 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 3.475010e-01 0.459 0 0
Cell Cycle, Mitotic R-HSA-69278 3.504139e-01 0.455 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.528452e-01 0.452 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 3.528452e-01 0.452 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.528452e-01 0.452 0 0
MAPK family signaling cascades R-HSA-5683057 3.546582e-01 0.450 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.581459e-01 0.446 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.581459e-01 0.446 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.581459e-01 0.446 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.581459e-01 0.446 0 0
Signaling by RAS mutants R-HSA-6802949 3.581459e-01 0.446 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.581459e-01 0.446 0 0
Signaling by NOTCH R-HSA-157118 3.590914e-01 0.445 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.634036e-01 0.440 0 0
Degradation of CDH1 R-HSA-9766229 3.737910e-01 0.427 0 0
Gap junction trafficking and regulation R-HSA-157858 3.737910e-01 0.427 0 0
DNA Damage Bypass R-HSA-73893 3.737910e-01 0.427 0 0
PI3K Cascade R-HSA-109704 3.789214e-01 0.421 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.789214e-01 0.421 0 0
Signaling by FGFR2 in disease R-HSA-5655253 3.789214e-01 0.421 0 0
HSF1-dependent transactivation R-HSA-3371571 3.840101e-01 0.416 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.840101e-01 0.416 0 0
mRNA 3'-end processing R-HSA-72187 3.890575e-01 0.410 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.890575e-01 0.410 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.894219e-01 0.410 0 0
Visual phototransduction R-HSA-2187338 3.923091e-01 0.406 0 0
Deubiquitination R-HSA-5688426 3.923716e-01 0.406 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.940638e-01 0.404 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.940638e-01 0.404 0 0
Smooth Muscle Contraction R-HSA-445355 3.940638e-01 0.404 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.940638e-01 0.404 0 0
Signaling by NTRKs R-HSA-166520 3.951903e-01 0.403 0 0
HDACs deacetylate histones R-HSA-3214815 4.039546e-01 0.394 0 0
Paracetamol ADME R-HSA-9753281 4.039546e-01 0.394 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.088397e-01 0.388 0 0
TNF signaling R-HSA-75893 4.088397e-01 0.388 0 0
NRAGE signals death through JNK R-HSA-193648 4.088397e-01 0.388 0 0
Signaling by EGFR R-HSA-177929 4.088397e-01 0.388 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.123453e-01 0.385 0 0
Regulation of CDH1 Function R-HSA-9764561 4.136851e-01 0.383 0 0
IRS-mediated signalling R-HSA-112399 4.136851e-01 0.383 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.136851e-01 0.383 0 0
Dectin-2 family R-HSA-5621480 4.136851e-01 0.383 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.136851e-01 0.383 0 0
Dual incision in TC-NER R-HSA-6782135 4.184911e-01 0.378 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.184911e-01 0.378 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.231092e-01 0.374 0 0
Interferon Signaling R-HSA-913531 4.231092e-01 0.374 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 4.232580e-01 0.373 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.232580e-01 0.373 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 4.232580e-01 0.373 0 0
Amino acid transport across the plasma membrane R-HSA-352230 4.232580e-01 0.373 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.279861e-01 0.369 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.279861e-01 0.369 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 4.279861e-01 0.369 0 0
Regulation of TP53 Activity R-HSA-5633007 4.292607e-01 0.367 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.326757e-01 0.364 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.326757e-01 0.364 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.326757e-01 0.364 0 0
MAP kinase activation R-HSA-450294 4.326757e-01 0.364 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.338811e-01 0.363 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.373272e-01 0.359 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.373272e-01 0.359 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.373272e-01 0.359 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.419408e-01 0.355 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.419408e-01 0.355 0 0
Semaphorin interactions R-HSA-373755 4.419408e-01 0.355 0 0
IGF1R signaling cascade R-HSA-2428924 4.465169e-01 0.350 0 0
Insulin receptor signalling cascade R-HSA-74751 4.465169e-01 0.350 0 0
SLC-mediated transmembrane transport R-HSA-425407 4.486329e-01 0.348 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.510557e-01 0.346 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.510557e-01 0.346 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.555576e-01 0.341 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.595963e-01 0.338 0 0
SLC-mediated transport of amino acids R-HSA-9958863 4.600228e-01 0.337 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.623084e-01 0.335 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.644517e-01 0.333 0 0
O-linked glycosylation of mucins R-HSA-913709 4.644517e-01 0.333 0 0
Transcription of the HIV genome R-HSA-167172 4.644517e-01 0.333 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.644517e-01 0.333 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.677088e-01 0.330 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.677088e-01 0.330 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.732017e-01 0.325 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.732017e-01 0.325 0 0
Interleukin-17 signaling R-HSA-448424 4.732017e-01 0.325 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.732017e-01 0.325 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.775233e-01 0.321 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 4.775233e-01 0.321 0 0
Metabolism of porphyrins R-HSA-189445 4.775233e-01 0.321 0 0
Disease R-HSA-1643685 4.806270e-01 0.318 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.818097e-01 0.317 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.818097e-01 0.317 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.818097e-01 0.317 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.860613e-01 0.313 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.860613e-01 0.313 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.902782e-01 0.310 0 0
Signaling by NOTCH4 R-HSA-9013694 4.902782e-01 0.310 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.942251e-01 0.306 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.944607e-01 0.306 0 0
Centrosome maturation R-HSA-380287 4.944607e-01 0.306 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.944607e-01 0.306 0 0
Diseases of glycosylation R-HSA-3781865 4.968311e-01 0.304 0 0
Signaling by NOTCH1 R-HSA-1980143 4.986093e-01 0.302 0 0
G2/M Transition R-HSA-69275 5.020177e-01 0.299 0 0
Peptide ligand-binding receptors R-HSA-375276 5.020177e-01 0.299 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.027240e-01 0.299 0 0
G alpha (12/13) signalling events R-HSA-416482 5.068052e-01 0.295 0 0
Integrin cell surface interactions R-HSA-216083 5.068052e-01 0.295 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.071702e-01 0.295 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.071702e-01 0.295 0 0
Signaling by MET R-HSA-6806834 5.148681e-01 0.288 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.148681e-01 0.288 0 0
Amyloid fiber formation R-HSA-977225 5.188504e-01 0.285 0 0
Mitotic Prometaphase R-HSA-68877 5.199005e-01 0.284 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.228002e-01 0.282 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.267179e-01 0.278 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.274340e-01 0.278 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.306036e-01 0.275 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.344577e-01 0.272 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.344577e-01 0.272 0 0
Post NMDA receptor activation events R-HSA-438064 5.458325e-01 0.263 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.495624e-01 0.260 0 0
Diseases of programmed cell death R-HSA-9645723 5.495624e-01 0.260 0 0
Extracellular matrix organization R-HSA-1474244 5.510029e-01 0.259 0 0
ER-Phagosome pathway R-HSA-1236974 5.532620e-01 0.257 0 0
Innate Immune System R-HSA-168249 5.535731e-01 0.257 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.569314e-01 0.254 0 0
Downstream TCR signaling R-HSA-202424 5.569314e-01 0.254 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.605709e-01 0.251 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.677611e-01 0.246 0 0
Signaling by Insulin receptor R-HSA-74752 5.677611e-01 0.246 0 0
Neuronal System R-HSA-112316 5.712134e-01 0.243 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.748345e-01 0.240 0 0
Collagen formation R-HSA-1474290 5.748345e-01 0.240 0 0
Mitotic Anaphase R-HSA-68882 5.779165e-01 0.238 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.783280e-01 0.238 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.802207e-01 0.236 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.852298e-01 0.233 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.886385e-01 0.230 0 0
Telomere Maintenance R-HSA-157579 5.886385e-01 0.230 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.920195e-01 0.228 0 0
ABC-family proteins mediated transport R-HSA-382556 5.986988e-01 0.223 0 0
Interleukin-1 signaling R-HSA-9020702 6.019977e-01 0.220 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.052696e-01 0.218 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.052696e-01 0.218 0 0
PI Metabolism R-HSA-1483255 6.052696e-01 0.218 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 6.071577e-01 0.217 0 0
Metabolism of vitamins and cofactors R-HSA-196854 6.120308e-01 0.213 0 0
rRNA processing R-HSA-72312 6.136858e-01 0.212 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.149261e-01 0.211 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.149261e-01 0.211 0 0
Nucleotide Excision Repair R-HSA-5696398 6.180926e-01 0.209 0 0
Metabolism of nucleotides R-HSA-15869 6.222618e-01 0.206 0 0
Gene Silencing by RNA R-HSA-211000 6.243482e-01 0.205 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.274377e-01 0.202 0 0
Stimuli-sensing channels R-HSA-2672351 6.274377e-01 0.202 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.425113e-01 0.192 0 0
M Phase R-HSA-68886 6.445864e-01 0.191 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.483698e-01 0.188 0 0
Chromatin organization R-HSA-4839726 6.491269e-01 0.188 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.629601e-01 0.179 0 0
Cell Cycle Checkpoints R-HSA-69620 6.668319e-01 0.176 0 0
Mitotic Prophase R-HSA-68875 6.681342e-01 0.175 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.708662e-01 0.173 0 0
Chromosome Maintenance R-HSA-73886 6.708662e-01 0.173 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.762634e-01 0.170 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.762634e-01 0.170 0 0
Developmental Cell Lineages R-HSA-9734767 6.763558e-01 0.170 0 0
Platelet degranulation R-HSA-114608 6.893751e-01 0.162 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.068507e-01 0.151 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.105560e-01 0.148 0 0
O-linked glycosylation R-HSA-5173105 7.187323e-01 0.143 0 0
Transport of small molecules R-HSA-382551 7.202427e-01 0.143 0 0
Parasite infection R-HSA-9664407 7.256306e-01 0.139 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.256306e-01 0.139 0 0
Leishmania phagocytosis R-HSA-9664417 7.256306e-01 0.139 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.278925e-01 0.138 0 0
Phospholipid metabolism R-HSA-1483257 7.321908e-01 0.135 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.323610e-01 0.135 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.323610e-01 0.135 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.367566e-01 0.133 0 0
Signaling by WNT R-HSA-195721 7.369860e-01 0.133 0 0
Cellular responses to stimuli R-HSA-8953897 7.471261e-01 0.127 0 0
Gastrulation R-HSA-9758941 7.474347e-01 0.126 0 0
Potential therapeutics for SARS R-HSA-9679191 7.495181e-01 0.125 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.495181e-01 0.125 0 0
Interleukin-1 family signaling R-HSA-446652 7.536340e-01 0.123 0 0
Arachidonate metabolism R-HSA-2142753 7.536340e-01 0.123 0 0
Protein localization R-HSA-9609507 7.556667e-01 0.122 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.596823e-01 0.119 0 0
HIV Life Cycle R-HSA-162587 7.636324e-01 0.117 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.655832e-01 0.116 0 0
Signaling by TGFB family members R-HSA-9006936 7.694370e-01 0.114 1 0
Separation of Sister Chromatids R-HSA-2467813 7.769570e-01 0.110 0 0
SLC transporter disorders R-HSA-5619102 7.824368e-01 0.107 0 0
GPCR downstream signalling R-HSA-388396 7.852546e-01 0.105 0 0
Hemostasis R-HSA-109582 7.943051e-01 0.100 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.964050e-01 0.099 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.980873e-01 0.098 0 0
Influenza Infection R-HSA-168255 8.046793e-01 0.094 0 0
Ion channel transport R-HSA-983712 8.202398e-01 0.086 0 0
DNA Repair R-HSA-73894 8.208503e-01 0.086 0 0
Cilium Assembly R-HSA-5617833 8.217265e-01 0.085 0 0
Glycosaminoglycan metabolism R-HSA-1630316 8.261137e-01 0.083 0 0
Sphingolipid metabolism R-HSA-428157 8.372961e-01 0.077 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.399783e-01 0.076 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 8.399783e-01 0.076 0 0
Signaling by GPCR R-HSA-372790 8.516763e-01 0.070 0 0
Muscle contraction R-HSA-397014 8.527451e-01 0.069 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.527451e-01 0.069 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 8.568971e-01 0.067 0 0
Drug ADME R-HSA-9748784 8.599144e-01 0.066 0 0
Cellular responses to stress R-HSA-2262752 8.603289e-01 0.065 0 0
HIV Infection R-HSA-162906 8.700239e-01 0.060 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 8.732301e-01 0.059 0 0
Chromatin modifying enzymes R-HSA-3247509 8.773833e-01 0.057 0 0
Cell surface interactions at the vascular wall R-HSA-202733 8.804093e-01 0.055 0 0
Diseases of metabolism R-HSA-5668914 8.847330e-01 0.053 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.899707e-01 0.051 0 0
G alpha (q) signalling events R-HSA-416476 9.045151e-01 0.044 0 0
Leishmania infection R-HSA-9658195 9.171495e-01 0.038 0 0
Parasitic Infection Pathways R-HSA-9824443 9.171495e-01 0.038 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.402091e-01 0.027 0 0
GPCR ligand binding R-HSA-500792 9.621220e-01 0.017 0 0
G alpha (i) signalling events R-HSA-418594 9.714438e-01 0.013 0 0
Fatty acid metabolism R-HSA-8978868 9.714438e-01 0.013 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.809505e-01 0.008 0 0
Post-translational protein modification R-HSA-597592 9.953749e-01 0.002 0 0
Sensory Perception R-HSA-9709957 9.997353e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.997551e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999710e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
Signaling by BMP R-HSA-201451 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 3.885781e-15 14.411 0 0
M Phase R-HSA-68886 5.218048e-15 14.282 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.994405e-15 14.155 0 0
Axon guidance R-HSA-422475 2.309264e-14 13.637 0 0
Cell Cycle, Mitotic R-HSA-69278 2.264855e-14 13.645 0 0
Nervous system development R-HSA-9675108 3.560485e-13 12.448 0 0
G2/M Checkpoints R-HSA-69481 1.791345e-12 11.747 0 0
Cell Cycle Checkpoints R-HSA-69620 5.997314e-12 11.222 0 0
Metabolism of RNA R-HSA-8953854 4.601308e-11 10.337 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.531509e-11 10.257 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.723406e-10 9.565 0 0
mRNA Splicing R-HSA-72172 8.574336e-10 9.067 0 0
Signaling by ROBO receptors R-HSA-376176 1.413658e-09 8.850 0 0
Cell-Cell communication R-HSA-1500931 9.818290e-09 8.008 0 0
Apoptosis R-HSA-109581 9.649919e-09 8.015 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.510069e-08 7.821 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.510069e-08 7.821 0 0
Mitotic Prometaphase R-HSA-68877 1.663323e-08 7.779 0 0
Programmed Cell Death R-HSA-5357801 2.764154e-08 7.558 0 0
Cellular responses to stimuli R-HSA-8953897 4.114420e-08 7.386 0 0
Mitotic Prophase R-HSA-68875 6.694147e-08 7.174 0 0
Cell junction organization R-HSA-446728 6.845827e-08 7.165 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.230626e-08 7.141 0 0
Adherens junctions interactions R-HSA-418990 9.369353e-08 7.028 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.487417e-08 7.023 0 0
Cellular responses to stress R-HSA-2262752 1.180254e-07 6.928 0 0
Regulation of CDH1 Function R-HSA-9764561 1.810758e-07 6.742 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.952006e-07 6.710 0 0
Apoptotic execution phase R-HSA-75153 2.207557e-07 6.656 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.873077e-07 6.542 0 0
Separation of Sister Chromatids R-HSA-2467813 4.011025e-07 6.397 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.408260e-07 6.356 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.366176e-07 6.360 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.074813e-07 6.295 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.592349e-07 6.252 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.592414e-07 6.252 0 0
Translation initiation complex formation R-HSA-72649 7.949780e-07 6.100 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.840010e-07 6.106 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.938424e-07 6.049 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.834694e-07 6.054 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.035815e-06 5.985 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.057107e-06 5.976 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.186342e-06 5.926 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.186342e-06 5.926 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.284807e-06 5.891 0 0
Mitotic Anaphase R-HSA-68882 1.295814e-06 5.887 0 0
G2/M Transition R-HSA-69275 1.329006e-06 5.876 0 0
Signal Transduction R-HSA-162582 1.414327e-06 5.849 1 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.479757e-06 5.830 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.767528e-06 5.753 0 0
Cell-cell junction organization R-HSA-421270 3.655315e-06 5.437 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.108668e-06 5.386 0 0
mRNA 3'-end processing R-HSA-72187 4.520600e-06 5.345 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.651109e-06 5.332 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.683020e-06 5.245 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.410349e-06 5.193 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.265348e-06 5.203 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.888003e-06 5.103 0 0
EPH-Ephrin signaling R-HSA-2682334 7.482221e-06 5.126 0 0
DNA Double Strand Break Response R-HSA-5693606 7.861384e-06 5.105 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.746367e-06 5.111 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.451099e-06 5.073 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.892299e-06 5.051 0 0
Homology Directed Repair R-HSA-5693538 9.308284e-06 5.031 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.145701e-05 4.941 0 0
Signaling by ERBB2 R-HSA-1227986 1.185871e-05 4.926 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.280238e-05 4.893 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.406105e-05 4.852 0 0
Cellular response to heat stress R-HSA-3371556 1.521622e-05 4.818 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.720159e-05 4.764 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.746607e-05 4.758 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.050337e-05 4.688 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.082236e-05 4.681 0 0
Signaling by RAS mutants R-HSA-6802949 2.586804e-05 4.587 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.586804e-05 4.587 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.586804e-05 4.587 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.586804e-05 4.587 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.586804e-05 4.587 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.385732e-05 4.622 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.385732e-05 4.622 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.593485e-05 4.586 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.929429e-05 4.533 0 0
Ribosome-associated quality control R-HSA-9948299 3.138904e-05 4.503 0 0
L1CAM interactions R-HSA-373760 3.361930e-05 4.473 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.754985e-05 4.425 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.943419e-05 4.404 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.140678e-05 4.383 0 0
Centrosome maturation R-HSA-380287 4.390804e-05 4.357 0 0
TCR signaling R-HSA-202403 4.623249e-05 4.335 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.098257e-05 4.293 0 0
Meiotic synapsis R-HSA-1221632 5.058246e-05 4.296 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.154182e-05 4.288 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.417397e-05 4.266 0 0
Degradation of CDH1 R-HSA-9766229 5.520485e-05 4.258 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.960875e-05 4.225 0 0
Nucleosome assembly R-HSA-774815 5.960875e-05 4.225 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.102201e-05 4.215 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.268217e-05 4.203 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.352592e-05 4.197 0 0
Signaling by ALK in cancer R-HSA-9700206 6.352592e-05 4.197 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.353172e-05 4.197 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.849406e-05 4.164 0 0
Signaling by Hippo R-HSA-2028269 6.559854e-05 4.183 0 0
DNA Replication R-HSA-69306 6.642130e-05 4.178 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.163950e-05 4.145 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.426014e-05 4.129 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.426014e-05 4.129 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.782718e-05 4.109 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.870221e-05 4.104 0 0
HDACs deacetylate histones R-HSA-3214815 7.996134e-05 4.097 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.573772e-05 4.067 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.032391e-04 3.986 0 0
Orc1 removal from chromatin R-HSA-68949 1.112037e-04 3.954 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.135739e-04 3.945 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.138176e-04 3.944 0 0
Meiosis R-HSA-1500620 1.162467e-04 3.935 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.360338e-04 3.866 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.360338e-04 3.866 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.400556e-04 3.854 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.510084e-04 3.821 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.566770e-04 3.805 0 0
Striated Muscle Contraction R-HSA-390522 1.646834e-04 3.783 0 0
MAPK family signaling cascades R-HSA-5683057 1.648070e-04 3.783 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.601655e-04 3.795 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.687552e-04 3.773 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.692209e-04 3.772 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.933418e-04 3.714 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.935453e-04 3.713 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.996667e-04 3.700 0 0
Negative regulation of MET activity R-HSA-6807004 2.110476e-04 3.676 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.154687e-04 3.667 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.160088e-04 3.666 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.256188e-04 3.647 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.275104e-04 3.643 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.296143e-04 3.639 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.624411e-04 3.581 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.602303e-04 3.585 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.668730e-04 3.574 0 0
Recycling pathway of L1 R-HSA-437239 2.695340e-04 3.569 0 0
Signaling by VEGF R-HSA-194138 2.927712e-04 3.533 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.992164e-04 3.524 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.992164e-04 3.524 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.102467e-04 3.508 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.418681e-04 3.466 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.313414e-04 3.480 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.418681e-04 3.466 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.190690e-04 3.496 0 0
Chromatin organization R-HSA-4839726 3.145549e-04 3.502 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.418681e-04 3.466 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.152325e-04 3.501 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.158900e-04 3.500 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.614293e-04 3.442 0 0
Smooth Muscle Contraction R-HSA-445355 3.643283e-04 3.439 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.867422e-04 3.413 0 0
Ephrin signaling R-HSA-3928664 3.924304e-04 3.406 0 0
Influenza Infection R-HSA-168255 4.284255e-04 3.368 0 0
Interferon Signaling R-HSA-913531 4.399391e-04 3.357 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.475348e-04 3.349 0 0
Host Interactions of HIV factors R-HSA-162909 4.483863e-04 3.348 0 0
Degradation of DVL R-HSA-4641258 4.614562e-04 3.336 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.614562e-04 3.336 0 0
Signaling by NOTCH4 R-HSA-9013694 5.063083e-04 3.296 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.252097e-04 3.280 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.654373e-04 3.248 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.786464e-04 3.238 0 0
Meiotic recombination R-HSA-912446 6.216036e-04 3.206 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.385127e-04 3.195 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 6.430929e-04 3.192 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.460366e-04 3.190 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.542450e-04 3.184 0 0
Signaling by EGFR R-HSA-177929 6.544854e-04 3.184 0 0
Chromatin modifying enzymes R-HSA-3247509 6.563588e-04 3.183 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.891102e-04 3.162 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.891102e-04 3.162 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.752652e-04 3.111 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.321358e-04 3.135 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.554106e-04 3.122 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.554106e-04 3.122 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.008744e-04 3.154 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.008744e-04 3.154 0 0
Gene expression (Transcription) R-HSA-74160 7.168898e-04 3.145 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.822064e-04 3.107 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.095282e-04 3.092 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.095282e-04 3.092 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.137637e-04 3.090 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.164115e-04 3.088 0 0
Regulation of Apoptosis R-HSA-169911 8.164115e-04 3.088 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.297655e-04 3.081 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.454839e-04 3.073 0 0
ESR-mediated signaling R-HSA-8939211 8.514902e-04 3.070 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.968557e-04 3.047 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.132602e-04 3.039 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.132602e-04 3.039 0 0
S Phase R-HSA-69242 9.148246e-04 3.039 0 0
Generation of second messenger molecules R-HSA-202433 9.157605e-04 3.038 0 0
RNA Polymerase I Transcription R-HSA-73864 9.607975e-04 3.017 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.704315e-04 3.013 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.027772e-03 2.988 0 0
Peptide chain elongation R-HSA-156902 1.068989e-03 2.971 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.098558e-03 2.959 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.133977e-03 2.945 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.133977e-03 2.945 0 0
Synthesis of DNA R-HSA-69239 1.198556e-03 2.921 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.214558e-03 2.916 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.215990e-03 2.915 0 0
DNA methylation R-HSA-5334118 1.251672e-03 2.903 0 0
Degradation of AXIN R-HSA-4641257 1.283535e-03 2.892 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.283535e-03 2.892 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.298080e-03 2.887 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.315043e-03 2.881 0 0
Protein ubiquitination R-HSA-8852135 1.322456e-03 2.879 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.367862e-03 2.864 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.371429e-03 2.863 0 0
MAP2K and MAPK activation R-HSA-5674135 1.394614e-03 2.856 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.394614e-03 2.856 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.424141e-03 2.846 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.440528e-03 2.841 0 0
Unwinding of DNA R-HSA-176974 1.446988e-03 2.840 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.536989e-03 2.813 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.598823e-03 2.796 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.566800e-03 2.805 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.555396e-03 2.808 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.771492e-03 2.752 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.748168e-03 2.757 0 0
Hedgehog 'off' state R-HSA-5610787 1.692785e-03 2.771 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.578919e-03 2.802 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.783486e-03 2.749 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.783486e-03 2.749 0 0
Nuclear import of Rev protein R-HSA-180746 1.801769e-03 2.744 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.801769e-03 2.744 0 0
Stabilization of p53 R-HSA-69541 1.957152e-03 2.708 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.957152e-03 2.708 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.022136e-03 2.694 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.022136e-03 2.694 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.068800e-03 2.684 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.068800e-03 2.684 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.169534e-03 2.664 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.169534e-03 2.664 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.181920e-03 2.661 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.181920e-03 2.661 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.220229e-03 2.654 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.235177e-03 2.651 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.235177e-03 2.651 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.241722e-03 2.649 0 0
Packaging Of Telomere Ends R-HSA-171306 2.241722e-03 2.649 0 0
Deubiquitination R-HSA-5688426 2.242574e-03 2.649 0 0
Signaling by Interleukins R-HSA-449147 2.268144e-03 2.644 0 0
Gene Silencing by RNA R-HSA-211000 2.317900e-03 2.635 0 0
Aggrephagy R-HSA-9646399 2.391215e-03 2.621 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.391215e-03 2.621 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.391215e-03 2.621 0 0
HIV Infection R-HSA-162906 2.616276e-03 2.582 0 0
Membrane Trafficking R-HSA-199991 2.684790e-03 2.571 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.146632e-03 2.502 0 0
FLT3 Signaling R-HSA-9607240 2.902108e-03 2.537 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.902108e-03 2.537 0 0
Signaling by MET R-HSA-6806834 2.718241e-03 2.566 0 0
FLT3 signaling in disease R-HSA-9682385 2.751258e-03 2.560 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.902108e-03 2.537 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.751258e-03 2.560 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.995524e-03 2.524 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.969905e-03 2.527 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.902108e-03 2.537 0 0
Interleukin-12 signaling R-HSA-9020591 3.233813e-03 2.490 0 0
Glycolysis R-HSA-70171 3.280351e-03 2.484 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.346137e-03 2.475 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.346137e-03 2.475 0 0
Hedgehog 'on' state R-HSA-5632684 3.346137e-03 2.475 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.361374e-03 2.473 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.383185e-03 2.471 0 0
Eukaryotic Translation Termination R-HSA-72764 3.467467e-03 2.460 0 0
Cilium Assembly R-HSA-5617833 3.509675e-03 2.455 0 0
Signaling by WNT R-HSA-195721 3.536158e-03 2.451 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.576078e-03 2.447 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.596072e-03 2.444 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.630870e-03 2.440 0 0
Ub-specific processing proteases R-HSA-5689880 3.719424e-03 2.430 0 0
Post NMDA receptor activation events R-HSA-438064 3.850557e-03 2.414 0 0
Interleukin-12 family signaling R-HSA-447115 3.850557e-03 2.414 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.875127e-03 2.412 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.969616e-03 2.401 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.077719e-03 2.390 0 0
Cellular Senescence R-HSA-2559583 4.087514e-03 2.389 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.231368e-03 2.374 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.232396e-03 2.373 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.288399e-03 2.368 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.288399e-03 2.368 0 0
Signaling by NOTCH R-HSA-157118 4.421150e-03 2.354 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.439511e-03 2.353 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.439511e-03 2.353 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.583407e-03 2.339 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.734328e-03 2.325 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.734328e-03 2.325 0 0
Signaling by PTK6 R-HSA-8848021 4.736183e-03 2.325 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.736183e-03 2.325 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.760797e-03 2.322 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.781324e-03 2.320 0 0
Sensory processing of sound R-HSA-9659379 4.819043e-03 2.317 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.913283e-03 2.309 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.913283e-03 2.309 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.982825e-03 2.303 0 0
EGFR downregulation R-HSA-182971 5.470483e-03 2.262 0 0
Metabolism of non-coding RNA R-HSA-194441 5.638430e-03 2.249 0 0
snRNP Assembly R-HSA-191859 5.638430e-03 2.249 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.921644e-03 2.228 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.921644e-03 2.228 0 0
Signaling by FGFR4 R-HSA-5654743 4.997935e-03 2.301 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.566985e-03 2.254 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.882475e-03 2.230 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.882475e-03 2.230 0 0
PTEN Regulation R-HSA-6807070 5.749207e-03 2.240 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.881801e-03 2.230 0 0
Regulation of signaling by CBL R-HSA-912631 6.237877e-03 2.205 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.279781e-03 2.202 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.316650e-03 2.200 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.683102e-03 2.175 0 0
Prolonged ERK activation events R-HSA-169893 6.689802e-03 2.175 0 0
Negative regulation of FLT3 R-HSA-9706369 6.689802e-03 2.175 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.854943e-03 2.164 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.854943e-03 2.164 0 0
RET signaling R-HSA-8853659 6.909923e-03 2.161 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.909923e-03 2.161 0 0
Signaling by FGFR3 R-HSA-5654741 6.978130e-03 2.156 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.978130e-03 2.156 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 7.142291e-03 2.146 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.142291e-03 2.146 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.317939e-03 2.136 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.617676e-03 2.118 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.617676e-03 2.118 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.883227e-03 2.103 0 0
Signal transduction by L1 R-HSA-445144 8.013679e-03 2.096 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.098258e-03 2.092 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.098258e-03 2.092 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.098258e-03 2.092 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.151845e-03 2.089 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.260820e-03 2.083 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.275998e-03 2.082 0 0
PCP/CE pathway R-HSA-4086400 8.358914e-03 2.078 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.764638e-03 2.057 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.910102e-03 2.050 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.910102e-03 2.050 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.078069e-03 2.042 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.271292e-03 2.033 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.323092e-03 2.030 0 0
Signal attenuation R-HSA-74749 9.339885e-03 2.030 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 9.339885e-03 2.030 0 0
Folding of actin by CCT/TriC R-HSA-390450 9.339885e-03 2.030 0 0
Frs2-mediated activation R-HSA-170968 9.351222e-03 2.029 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.351222e-03 2.029 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.458965e-03 2.024 0 0
RNA Polymerase II Transcription R-HSA-73857 9.553699e-03 2.020 0 0
Semaphorin interactions R-HSA-373755 9.801094e-03 2.009 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.138539e-02 1.944 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.138539e-02 1.944 0 0
Basigin interactions R-HSA-210991 1.015005e-02 1.994 0 0
Signaling by ERBB4 R-HSA-1236394 9.988493e-03 2.001 0 0
HATs acetylate histones R-HSA-3214847 1.005331e-02 1.998 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.194632e-02 1.923 0 0
HIV Life Cycle R-HSA-162587 1.063025e-02 1.973 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.211371e-02 1.917 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.245457e-02 1.905 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.194632e-02 1.923 0 0
G1/S Transition R-HSA-69206 1.116699e-02 1.952 0 0
Co-inhibition by PD-1 R-HSA-389948 1.190165e-02 1.924 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.148340e-02 1.940 0 0
Activation of BH3-only proteins R-HSA-114452 1.145370e-02 1.941 0 0
Defective pyroptosis R-HSA-9710421 1.138250e-02 1.944 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.228450e-02 1.911 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.156228e-02 1.937 0 0
Selenocysteine synthesis R-HSA-2408557 1.229988e-02 1.910 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.140625e-02 1.943 0 0
Muscle contraction R-HSA-397014 1.246935e-02 1.904 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.247676e-02 1.904 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.247676e-02 1.904 0 0
Regulation of PTEN localization R-HSA-8948747 1.247676e-02 1.904 0 0
UCH proteinases R-HSA-5689603 1.264457e-02 1.898 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.268880e-02 1.897 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.268880e-02 1.897 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.280139e-02 1.893 0 0
Platelet degranulation R-HSA-114608 1.330321e-02 1.876 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.332867e-02 1.875 0 0
Regulation of TP53 Activity R-HSA-5633007 1.342848e-02 1.872 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.346127e-02 1.871 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.358563e-02 1.867 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.405421e-02 1.852 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.448306e-02 1.839 0 0
Signaling by Hedgehog R-HSA-5358351 1.459198e-02 1.836 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.461523e-02 1.835 0 0
Neutrophil degranulation R-HSA-6798695 1.484491e-02 1.828 0 0
Viral mRNA Translation R-HSA-192823 1.493354e-02 1.826 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.512383e-02 1.820 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.515780e-02 1.819 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.533030e-02 1.814 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.533030e-02 1.814 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.545833e-02 1.811 0 0
mTORC1-mediated signalling R-HSA-166208 1.567154e-02 1.805 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.584792e-02 1.800 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.584792e-02 1.800 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.601623e-02 1.795 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.623783e-02 1.789 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.623783e-02 1.789 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.638832e-02 1.785 0 0
Developmental Biology R-HSA-1266738 1.640980e-02 1.785 0 0
HSF1-dependent transactivation R-HSA-3371571 1.685915e-02 1.773 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.685915e-02 1.773 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.694318e-02 1.771 0 0
ER-Phagosome pathway R-HSA-1236974 1.694833e-02 1.771 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.771644e-02 1.752 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.771644e-02 1.752 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.771644e-02 1.752 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.771644e-02 1.752 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.771644e-02 1.752 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.771644e-02 1.752 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.771644e-02 1.752 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.771644e-02 1.752 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.771644e-02 1.752 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.771644e-02 1.752 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.771644e-02 1.752 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.803086e-02 1.744 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.803086e-02 1.744 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.815174e-02 1.741 0 0
Cellular response to starvation R-HSA-9711097 1.820452e-02 1.740 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.838591e-02 1.736 0 0
Reproduction R-HSA-1474165 1.856272e-02 1.731 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.447277e-02 1.611 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.447277e-02 1.611 0 0
Gap junction degradation R-HSA-190873 2.500970e-02 1.602 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.326505e-02 1.633 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.326505e-02 1.633 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.313057e-02 1.636 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.265082e-02 1.645 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.307479e-02 1.637 0 0
Ca-dependent events R-HSA-111996 2.121869e-02 1.673 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.183733e-02 1.661 0 0
Integrin signaling R-HSA-354192 1.938214e-02 1.713 0 0
Chromosome Maintenance R-HSA-73886 2.009005e-02 1.697 0 0
Signaling by FGFR2 R-HSA-5654738 1.961930e-02 1.707 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.500970e-02 1.602 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.154312e-02 1.667 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.326505e-02 1.633 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.326505e-02 1.633 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.326505e-02 1.633 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.265082e-02 1.645 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.076985e-02 1.683 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.108922e-02 1.676 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.313057e-02 1.636 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.207946e-02 1.656 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.316311e-02 1.635 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.500970e-02 1.602 0 0
Amyloid fiber formation R-HSA-977225 2.175807e-02 1.662 0 0
Cellular response to hypoxia R-HSA-1234174 2.430336e-02 1.614 0 0
Nephrin family interactions R-HSA-373753 2.244198e-02 1.649 0 0
Glucose metabolism R-HSA-70326 2.365091e-02 1.626 0 0
ABC-family proteins mediated transport R-HSA-382556 1.945630e-02 1.711 0 0
Cleavage of the damaged purine R-HSA-110331 1.898334e-02 1.722 0 0
Depurination R-HSA-73927 2.207946e-02 1.656 0 0
Maturation of protein E R-HSA-9694493 2.447277e-02 1.611 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.447277e-02 1.611 0 0
Maturation of protein E R-HSA-9683683 2.447277e-02 1.611 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.121869e-02 1.673 0 0
Depyrimidination R-HSA-73928 2.121869e-02 1.673 0 0
Cellular response to chemical stress R-HSA-9711123 2.543667e-02 1.595 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.559638e-02 1.592 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.565395e-02 1.591 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.611385e-02 1.583 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.627837e-02 1.580 0 0
RAF activation R-HSA-5673000 2.655401e-02 1.576 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.681215e-02 1.572 0 0
Diseases of programmed cell death R-HSA-9645723 2.702957e-02 1.568 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.740091e-02 1.562 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.740091e-02 1.562 0 0
Long-term potentiation R-HSA-9620244 2.768328e-02 1.558 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.768328e-02 1.558 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.768328e-02 1.558 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.776367e-02 1.557 0 0
Interleukin-1 family signaling R-HSA-446652 2.845534e-02 1.546 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.997616e-02 1.523 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.997616e-02 1.523 0 0
Interleukin-6 signaling R-HSA-1059683 2.997616e-02 1.523 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.997616e-02 1.523 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.020237e-02 1.520 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.065487e-02 1.514 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.078176e-02 1.512 0 0
Signalling to ERKs R-HSA-187687 3.078176e-02 1.512 0 0
SARS-CoV Infections R-HSA-9679506 3.122929e-02 1.505 0 0
Signaling by FGFR1 R-HSA-5654736 3.129547e-02 1.505 0 0
MET interacts with TNS proteins R-HSA-8875513 3.136680e-02 1.504 0 0
DAG and IP3 signaling R-HSA-1489509 3.167089e-02 1.499 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.167089e-02 1.499 0 0
Somitogenesis R-HSA-9824272 3.167089e-02 1.499 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.198827e-02 1.495 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.198827e-02 1.495 0 0
Downstream TCR signaling R-HSA-202424 3.248014e-02 1.488 0 0
tRNA processing in the nucleus R-HSA-6784531 3.253980e-02 1.488 0 0
Metalloprotease DUBs R-HSA-5689901 3.283158e-02 1.484 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.307138e-02 1.481 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.351741e-02 1.475 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.351741e-02 1.475 0 0
Formation of apoptosome R-HSA-111458 3.351741e-02 1.475 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.351741e-02 1.475 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.351741e-02 1.475 0 0
Regulation of CDH11 function R-HSA-9762292 3.351741e-02 1.475 0 0
Josephin domain DUBs R-HSA-5689877 3.351741e-02 1.475 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.353710e-02 1.474 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.539766e-02 1.451 0 0
CaM pathway R-HSA-111997 3.546829e-02 1.450 0 0
Calmodulin induced events R-HSA-111933 3.546829e-02 1.450 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.586480e-02 1.445 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.586480e-02 1.445 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.620102e-02 1.441 0 0
DNA Repair R-HSA-73894 3.634245e-02 1.440 0 0
DNA strand elongation R-HSA-69190 3.718697e-02 1.430 0 0
MHC class II antigen presentation R-HSA-2132295 3.767346e-02 1.424 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.767346e-02 1.424 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.784313e-02 1.422 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.824770e-02 1.417 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.855055e-02 1.414 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.860662e-02 1.413 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.860662e-02 1.413 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.945418e-02 1.404 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.945418e-02 1.404 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.949115e-02 1.404 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.991948e-02 1.399 0 0
Signaling by NOTCH1 R-HSA-1980143 4.151742e-02 1.382 0 0
MTOR signalling R-HSA-165159 4.333205e-02 1.363 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.362665e-02 1.360 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.362665e-02 1.360 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.503578e-02 1.346 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.503578e-02 1.346 0 0
Syndecan interactions R-HSA-3000170 4.669224e-02 1.331 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.691567e-02 1.329 0 0
Translesion synthesis by REV1 R-HSA-110312 4.691567e-02 1.329 0 0
Translesion Synthesis by POLH R-HSA-110320 4.753709e-02 1.323 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.814947e-02 1.317 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.859668e-02 1.313 0 0
Death Receptor Signaling R-HSA-73887 4.879389e-02 1.312 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.318959e-02 1.199 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 6.318959e-02 1.199 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 6.318959e-02 1.199 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 6.318959e-02 1.199 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 6.318959e-02 1.199 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.917078e-02 1.308 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.088862e-02 1.149 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 7.088862e-02 1.149 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 7.088862e-02 1.149 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 7.088862e-02 1.149 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 7.088862e-02 1.149 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.422564e-02 1.192 0 0
Formation of annular gap junctions R-HSA-196025 6.422564e-02 1.192 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.537797e-02 1.257 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.537797e-02 1.257 0 0
MET activates RAS signaling R-HSA-8851805 6.878046e-02 1.163 0 0
Repression of WNT target genes R-HSA-4641265 6.878046e-02 1.163 0 0
Translesion synthesis by POLI R-HSA-5656121 5.722675e-02 1.242 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.879229e-02 1.162 0 0
Translesion synthesis by POLK R-HSA-5655862 6.879229e-02 1.162 0 0
Formation of definitive endoderm R-HSA-9823730 5.660353e-02 1.247 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.660353e-02 1.247 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.470040e-02 1.262 0 0
Signaling by Erythropoietin R-HSA-9006335 5.214228e-02 1.283 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.214228e-02 1.283 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.214228e-02 1.283 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.927568e-02 1.307 0 0
Activation of the pre-replicative complex R-HSA-68962 5.994480e-02 1.222 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.919226e-02 1.228 0 0
HCMV Early Events R-HSA-9609690 6.315680e-02 1.200 0 0
DAP12 signaling R-HSA-2424491 5.994480e-02 1.222 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.781292e-02 1.238 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.537797e-02 1.257 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.644549e-02 1.178 0 0
TNF signaling R-HSA-75893 5.781292e-02 1.238 0 0
HSF1 activation R-HSA-3371511 7.190372e-02 1.143 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.257669e-02 1.279 0 0
Proteasome assembly R-HSA-9907900 5.486677e-02 1.261 0 0
Regulation of IFNG signaling R-HSA-877312 6.878046e-02 1.163 0 0
Translation R-HSA-72766 6.921564e-02 1.160 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.918927e-02 1.228 0 0
MAP kinase activation R-HSA-450294 5.320021e-02 1.274 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.197001e-02 1.143 0 0
Disorders of Developmental Biology R-HSA-9675151 6.879229e-02 1.162 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.320722e-02 1.135 0 0
Signaling by LTK R-HSA-9842663 6.878046e-02 1.163 0 0
Disorders of Nervous System Development R-HSA-9697154 6.878046e-02 1.163 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.878046e-02 1.163 0 0
Pervasive developmental disorders R-HSA-9005895 6.878046e-02 1.163 0 0
Autophagy R-HSA-9612973 5.509618e-02 1.259 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.620457e-02 1.250 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.613879e-02 1.180 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.422564e-02 1.192 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.537797e-02 1.257 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.878046e-02 1.163 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.878046e-02 1.163 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.320021e-02 1.274 0 0
Signaling by ALK R-HSA-201556 5.248101e-02 1.280 0 0
Interleukin-1 signaling R-HSA-9020702 5.746773e-02 1.241 0 0
Macroautophagy R-HSA-1632852 6.628127e-02 1.179 0 0
Regulated Necrosis R-HSA-5218859 5.905892e-02 1.229 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.320722e-02 1.135 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.537797e-02 1.257 0 0
Signaling by NOTCH3 R-HSA-9012852 5.220822e-02 1.282 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.878046e-02 1.163 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.878046e-02 1.163 0 0
Base Excision Repair R-HSA-73884 5.408682e-02 1.267 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.248101e-02 1.280 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.761901e-02 1.170 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.388877e-02 1.195 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.286451e-02 1.277 0 0
Modulation by Mtb of host immune system R-HSA-9637628 6.422564e-02 1.192 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.424977e-02 1.129 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.775039e-02 1.109 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.775039e-02 1.109 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.775039e-02 1.109 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.781667e-02 1.109 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.901707e-02 1.102 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.069209e-02 1.093 0 0
Potential therapeutics for SARS R-HSA-9679191 8.153137e-02 1.089 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.153137e-02 1.089 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.161137e-02 1.088 0 0
ALK mutants bind TKIs R-HSA-9700645 8.216006e-02 1.085 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 8.216006e-02 1.085 0 0
ABC transporter disorders R-HSA-5619084 8.248005e-02 1.084 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.261126e-02 1.083 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.330822e-02 1.079 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.330822e-02 1.079 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.372300e-02 1.077 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.372300e-02 1.077 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.381351e-02 1.077 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.381351e-02 1.077 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.421953e-02 1.075 0 0
Kinesins R-HSA-983189 8.424962e-02 1.074 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.764269e-02 1.057 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 8.764269e-02 1.057 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.764269e-02 1.057 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.764269e-02 1.057 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.838805e-02 1.054 0 0
PLC beta mediated events R-HSA-112043 9.189080e-02 1.037 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.189080e-02 1.037 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.445738e-02 1.025 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 9.566691e-02 1.019 0 0
PKR-mediated signaling R-HSA-9833482 9.606190e-02 1.017 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.606190e-02 1.017 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 9.614442e-02 1.017 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 9.614442e-02 1.017 0 0
IRE1alpha activates chaperones R-HSA-381070 9.940418e-02 1.003 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.995042e-02 1.000 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.001634e-01 0.999 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.004293e-01 0.998 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.004293e-01 0.998 0 0
NRAGE signals death through JNK R-HSA-193648 1.007466e-01 0.997 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.022774e-01 0.990 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.022774e-01 0.990 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.022774e-01 0.990 0 0
Pexophagy R-HSA-9664873 1.022774e-01 0.990 0 0
Interleukin receptor SHC signaling R-HSA-912526 1.029171e-01 0.988 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.030265e-01 0.987 0 0
Regulation of TP53 Expression R-HSA-6804754 1.030265e-01 0.987 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.030265e-01 0.987 0 0
C6 deamination of adenosine R-HSA-75102 1.030265e-01 0.987 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.030265e-01 0.987 0 0
Immune System R-HSA-168256 1.033235e-01 0.986 0 0
Telomere Maintenance R-HSA-157579 1.039818e-01 0.983 0 0
Viral Infection Pathways R-HSA-9824446 1.057716e-01 0.976 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.072690e-01 0.970 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.072690e-01 0.970 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.082232e-01 0.966 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.097089e-01 0.960 0 0
Dual Incision in GG-NER R-HSA-5696400 1.097089e-01 0.960 0 0
Signaling by FGFR R-HSA-190236 1.108853e-01 0.955 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.109266e-01 0.955 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.109266e-01 0.955 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.109266e-01 0.955 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.109266e-01 0.955 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.110564e-01 0.954 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.150867e-01 0.939 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.150867e-01 0.939 0 0
Interleukin-17 signaling R-HSA-448424 1.153386e-01 0.938 0 0
Selective autophagy R-HSA-9663891 1.162536e-01 0.935 0 0
Deadenylation of mRNA R-HSA-429947 1.169703e-01 0.932 0 0
Interleukin-6 family signaling R-HSA-6783589 1.169703e-01 0.932 0 0
Erythropoietin activates RAS R-HSA-9027284 1.185559e-01 0.926 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.185559e-01 0.926 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.185559e-01 0.926 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.185559e-01 0.926 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 1.189302e-01 0.925 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.201023e-01 0.920 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.202744e-01 0.920 0 0
Interleukin-37 signaling R-HSA-9008059 1.202744e-01 0.920 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.221385e-01 0.913 0 0
PECAM1 interactions R-HSA-210990 1.244132e-01 0.905 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.244132e-01 0.905 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.244808e-01 0.905 0 0
Signaling by LTK in cancer R-HSA-9842640 1.244808e-01 0.905 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.244808e-01 0.905 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.244808e-01 0.905 0 0
Inositol phosphate metabolism R-HSA-1483249 1.260395e-01 0.899 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.266184e-01 0.898 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.266184e-01 0.898 0 0
KIT mutants bind TKIs R-HSA-9669921 1.266184e-01 0.898 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.266184e-01 0.898 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.266184e-01 0.898 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.266184e-01 0.898 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.266184e-01 0.898 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.266184e-01 0.898 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.266184e-01 0.898 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.266184e-01 0.898 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.266184e-01 0.898 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.266184e-01 0.898 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.266184e-01 0.898 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.266184e-01 0.898 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.266184e-01 0.898 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.266184e-01 0.898 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.266184e-01 0.898 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.266184e-01 0.898 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.266184e-01 0.898 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.266184e-01 0.898 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.266184e-01 0.898 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.266184e-01 0.898 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.266184e-01 0.898 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.266184e-01 0.898 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.266184e-01 0.898 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.266184e-01 0.898 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.266184e-01 0.898 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.266184e-01 0.898 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.266184e-01 0.898 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.266184e-01 0.898 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.272165e-01 0.895 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.273440e-01 0.895 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.273440e-01 0.895 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.273440e-01 0.895 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.273440e-01 0.895 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.273440e-01 0.895 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.372110e-01 0.625 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.372110e-01 0.625 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.372110e-01 0.625 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.372110e-01 0.625 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.372110e-01 0.625 0 0
Hereditary fructose intolerance R-HSA-5657560 2.372110e-01 0.625 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.372110e-01 0.625 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.372110e-01 0.625 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.372110e-01 0.625 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.372110e-01 0.625 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.372110e-01 0.625 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.372110e-01 0.625 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.372110e-01 0.625 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.372110e-01 0.625 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 1.477964e-01 0.830 0 0
TRKA activation by NGF R-HSA-187042 1.477964e-01 0.830 0 0
PLC-gamma1 signalling R-HSA-167021 1.477964e-01 0.830 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.477964e-01 0.830 0 0
MET activates PTPN11 R-HSA-8865999 1.477964e-01 0.830 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.956128e-01 0.709 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.956128e-01 0.709 0 0
SOS-mediated signalling R-HSA-112412 1.554001e-01 0.809 0 0
Recycling of eIF2:GDP R-HSA-72731 1.554001e-01 0.809 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.554001e-01 0.809 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.449873e-01 0.611 0 0
IRS activation R-HSA-74713 2.449873e-01 0.611 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.449873e-01 0.611 0 0
Type I hemidesmosome assembly R-HSA-446107 1.883943e-01 0.725 0 0
Interleukin-18 signaling R-HSA-9012546 1.883943e-01 0.725 0 0
MET receptor recycling R-HSA-8875656 1.883943e-01 0.725 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.883943e-01 0.725 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.883943e-01 0.725 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.483715e-01 0.829 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.483715e-01 0.829 0 0
Signaling by AXIN mutants R-HSA-4839735 1.483715e-01 0.829 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.483715e-01 0.829 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.381007e-01 0.860 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.739342e-01 0.760 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.739342e-01 0.760 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.739342e-01 0.760 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.739342e-01 0.760 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.739342e-01 0.760 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.739342e-01 0.760 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.229664e-01 0.652 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 2.229664e-01 0.652 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.229664e-01 0.652 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 2.229664e-01 0.652 0 0
Calcineurin activates NFAT R-HSA-2025928 2.229664e-01 0.652 0 0
MAPK1 (ERK2) activation R-HSA-112411 2.229664e-01 0.652 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.589538e-01 0.799 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.008696e-01 0.697 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.586461e-01 0.587 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 2.586461e-01 0.587 0 0
2-LTR circle formation R-HSA-164843 2.586461e-01 0.587 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.809917e-01 0.742 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.634061e-01 0.787 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.634061e-01 0.787 0 0
Regulation of KIT signaling R-HSA-1433559 2.289397e-01 0.640 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 1.829019e-01 0.738 0 0
DCC mediated attractive signaling R-HSA-418885 2.579065e-01 0.589 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.579065e-01 0.589 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.280805e-01 0.642 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.821550e-01 0.740 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.799243e-01 0.745 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.004412e-01 0.698 0 0
Late endosomal microautophagy R-HSA-9615710 2.004412e-01 0.698 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.965624e-01 0.706 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.461974e-01 0.609 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.652644e-01 0.782 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.961044e-01 0.708 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.451549e-01 0.611 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.355384e-01 0.628 0 0
G-protein beta:gamma signalling R-HSA-397795 1.639352e-01 0.785 0 0
Signaling by SCF-KIT R-HSA-1433557 2.582965e-01 0.588 0 0
Nucleotide Excision Repair R-HSA-5696398 1.759068e-01 0.755 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.480346e-01 0.830 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.004412e-01 0.698 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.194016e-01 0.659 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.394748e-01 0.856 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.965624e-01 0.706 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 1.860376e-01 0.730 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.406147e-01 0.619 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.289397e-01 0.640 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.310376e-01 0.883 0 0
Protein folding R-HSA-391251 2.271618e-01 0.644 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.922668e-01 0.716 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.799243e-01 0.745 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.970063e-01 0.706 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.319644e-01 0.880 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.639352e-01 0.785 0 0
Interleukin-15 signaling R-HSA-8983432 1.739342e-01 0.760 0 0
IGF1R signaling cascade R-HSA-2428924 1.846597e-01 0.734 0 0
Apoptotic factor-mediated response R-HSA-111471 2.040808e-01 0.690 0 0
Attenuation phase R-HSA-3371568 1.921141e-01 0.716 0 0
GPER1 signaling R-HSA-9634597 2.326711e-01 0.633 0 0
Signaling by Leptin R-HSA-2586552 2.586461e-01 0.587 0 0
Myogenesis R-HSA-525793 1.478594e-01 0.830 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.739342e-01 0.760 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.965624e-01 0.706 0 0
FOXO-mediated transcription R-HSA-9614085 2.414219e-01 0.617 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.171244e-01 0.663 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.567426e-01 0.805 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.202044e-01 0.657 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.449873e-01 0.611 0 0
Activation of RAC1 R-HSA-428540 1.483715e-01 0.829 0 0
Trafficking of AMPA receptors R-HSA-399719 1.340737e-01 0.873 0 0
Growth hormone receptor signaling R-HSA-982772 2.032614e-01 0.692 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.032614e-01 0.692 0 0
Budding and maturation of HIV virion R-HSA-162588 2.389673e-01 0.622 0 0
Opioid Signalling R-HSA-111885 1.580577e-01 0.801 0 0
Interferon alpha/beta signaling R-HSA-909733 1.650169e-01 0.782 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.445183e-01 0.612 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.739342e-01 0.760 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.319644e-01 0.880 0 0
G-protein mediated events R-HSA-112040 1.464674e-01 0.834 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.708233e-01 0.767 0 0
NADE modulates death signalling R-HSA-205025 1.956128e-01 0.709 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.449873e-01 0.611 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.229664e-01 0.652 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.589538e-01 0.799 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.586461e-01 0.587 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.280805e-01 0.642 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.639352e-01 0.785 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.528464e-01 0.597 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.873703e-01 0.727 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.170112e-01 0.664 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.170112e-01 0.664 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.170112e-01 0.664 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.170112e-01 0.664 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.247885e-01 0.648 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.416897e-01 0.849 0 0
Vesicle-mediated transport R-HSA-5653656 1.378383e-01 0.861 0 0
Signaling by TGFB family members R-HSA-9006936 1.353223e-01 0.869 1 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.914568e-01 0.718 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.247885e-01 0.648 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.759068e-01 0.755 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.268859e-01 0.644 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.138019e-01 0.670 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 2.229664e-01 0.652 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.528464e-01 0.597 0 0
G alpha (12/13) signalling events R-HSA-416482 1.961044e-01 0.708 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.326711e-01 0.633 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.630030e-01 0.788 0 0
Signaling by NTRKs R-HSA-166520 1.937421e-01 0.713 0 0
Adaptive Immune System R-HSA-1280218 1.311702e-01 0.882 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.630030e-01 0.788 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.630030e-01 0.788 0 0
Rap1 signalling R-HSA-392517 2.280805e-01 0.642 0 0
Generic Transcription Pathway R-HSA-212436 1.314646e-01 0.881 0 0
Protein methylation R-HSA-8876725 2.579065e-01 0.589 0 0
Signaling by FGFR in disease R-HSA-1226099 1.528539e-01 0.816 0 0
Interleukin-27 signaling R-HSA-9020956 2.586461e-01 0.587 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.567326e-01 0.591 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.389673e-01 0.622 0 0
Circadian clock R-HSA-9909396 1.577589e-01 0.802 0 0
DAP12 interactions R-HSA-2172127 1.732254e-01 0.761 0 0
Inhibition of PKR R-HSA-169131 2.372110e-01 0.625 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.477964e-01 0.830 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.956128e-01 0.709 0 0
RSK activation R-HSA-444257 1.883943e-01 0.725 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.586461e-01 0.587 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.809917e-01 0.742 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.032614e-01 0.692 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.965624e-01 0.706 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.170112e-01 0.664 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.634061e-01 0.787 0 0
rRNA processing R-HSA-72312 1.362235e-01 0.866 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.907788e-01 0.719 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.821550e-01 0.740 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.289397e-01 0.640 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.646077e-01 0.784 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.138019e-01 0.670 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.639352e-01 0.785 0 0
Signaling by NODAL R-HSA-1181150 2.528464e-01 0.597 0 0
Gap junction trafficking and regulation R-HSA-157858 1.566390e-01 0.805 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.389673e-01 0.622 0 0
G0 and Early G1 R-HSA-1538133 1.486386e-01 0.828 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.589538e-01 0.799 0 0
Signaling by Activin R-HSA-1502540 2.579065e-01 0.589 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.486191e-01 0.604 0 0
Gap junction trafficking R-HSA-190828 1.732254e-01 0.761 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.846597e-01 0.734 0 0
PTK6 Activates STAT3 R-HSA-8849474 2.449873e-01 0.611 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.449873e-01 0.611 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.229664e-01 0.652 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.634061e-01 0.787 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.040808e-01 0.690 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.639352e-01 0.785 0 0
Assembly Of The HIV Virion R-HSA-175474 1.634061e-01 0.787 0 0
CASP4 inflammasome assembly R-HSA-9948001 2.586461e-01 0.587 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.829019e-01 0.738 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.596062e-01 0.797 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.554001e-01 0.809 0 0
NF-kB is activated and signals survival R-HSA-209560 1.483715e-01 0.829 0 0
Non-canonical inflammasome activation R-HSA-9686114 2.289397e-01 0.640 0 0
Glycogen synthesis R-HSA-3322077 2.528464e-01 0.597 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.448604e-01 0.839 0 0
Glycogen storage diseases R-HSA-3229121 1.809917e-01 0.742 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.289397e-01 0.640 0 0
p75NTR signals via NF-kB R-HSA-193639 2.579065e-01 0.589 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.679118e-01 0.775 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.739342e-01 0.760 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 2.449873e-01 0.611 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.626293e-01 0.581 0 0
Gastrulation R-HSA-9758941 2.633486e-01 0.579 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.685779e-01 0.571 0 0
MET promotes cell motility R-HSA-8875878 2.686075e-01 0.571 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.686075e-01 0.571 0 0
HCMV Late Events R-HSA-9610379 2.733908e-01 0.563 0 0
Selenoamino acid metabolism R-HSA-2408522 2.737130e-01 0.563 0 0
Insulin receptor signalling cascade R-HSA-74751 2.745602e-01 0.561 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.758930e-01 0.559 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.777614e-01 0.556 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.777614e-01 0.556 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.782330e-01 0.556 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.782330e-01 0.556 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.796266e-01 0.553 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.796266e-01 0.553 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.796266e-01 0.553 0 0
Dual incision in TC-NER R-HSA-6782135 2.860723e-01 0.544 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.869935e-01 0.542 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.875373e-01 0.541 0 0
Phosphorylation of the APC/C R-HSA-176412 2.875373e-01 0.541 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.875373e-01 0.541 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.875373e-01 0.541 0 0
Regulation of BACH1 activity R-HSA-9708530 2.875373e-01 0.541 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.877200e-01 0.541 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.894384e-01 0.538 0 0
Hemostasis R-HSA-109582 2.901637e-01 0.537 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.903292e-01 0.537 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.914333e-01 0.535 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 2.914333e-01 0.535 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.914333e-01 0.535 0 0
Pentose phosphate pathway disease R-HSA-6791465 2.947593e-01 0.531 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.947593e-01 0.531 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.947593e-01 0.531 0 0
Phosphorylation of Emi1 R-HSA-176417 2.947593e-01 0.531 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.947593e-01 0.531 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.947593e-01 0.531 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.947593e-01 0.531 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.947593e-01 0.531 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.947593e-01 0.531 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.947593e-01 0.531 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.947593e-01 0.531 0 0
TRAIL signaling R-HSA-75158 2.947593e-01 0.531 0 0
Signaling by APC mutants R-HSA-4839744 2.949984e-01 0.530 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.949984e-01 0.530 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.949984e-01 0.530 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.949984e-01 0.530 0 0
Interleukin-2 signaling R-HSA-9020558 2.949984e-01 0.530 0 0
Suppression of apoptosis R-HSA-9635465 2.949984e-01 0.530 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 2.955970e-01 0.529 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.985068e-01 0.525 0 0
Neurexins and neuroligins R-HSA-6794361 2.985068e-01 0.525 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.005721e-01 0.522 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.021548e-01 0.520 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.040959e-01 0.517 0 0
HCMV Infection R-HSA-9609646 3.043199e-01 0.517 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.071586e-01 0.513 0 0
Interleukin-2 family signaling R-HSA-451927 3.071586e-01 0.513 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.120299e-01 0.506 0 0
Diseases of DNA repair R-HSA-9675135 3.120299e-01 0.506 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.156905e-01 0.501 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.176086e-01 0.498 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.176086e-01 0.498 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.176086e-01 0.498 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.176086e-01 0.498 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.176086e-01 0.498 0 0
Synthesis of PG R-HSA-1483148 3.176086e-01 0.498 0 0
Metabolism of polyamines R-HSA-351202 3.184640e-01 0.497 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.218284e-01 0.492 0 0
Mitophagy R-HSA-5205647 3.218284e-01 0.492 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.218284e-01 0.492 0 0
Signaling by NOTCH2 R-HSA-1980145 3.218284e-01 0.492 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.233344e-01 0.490 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.268646e-01 0.486 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.268646e-01 0.486 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.268646e-01 0.486 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.302940e-01 0.481 0 0
FGFR2 alternative splicing R-HSA-6803529 3.302940e-01 0.481 0 0
Notch-HLH transcription pathway R-HSA-350054 3.302940e-01 0.481 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 3.316303e-01 0.479 0 0
ERKs are inactivated R-HSA-202670 3.316303e-01 0.479 0 0
Integration of provirus R-HSA-162592 3.316303e-01 0.479 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.316303e-01 0.479 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.338053e-01 0.477 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.338053e-01 0.477 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.338053e-01 0.477 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 3.338053e-01 0.477 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.338053e-01 0.477 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.338053e-01 0.477 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.338053e-01 0.477 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.338053e-01 0.477 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.338053e-01 0.477 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.338053e-01 0.477 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.338053e-01 0.477 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.338053e-01 0.477 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.338053e-01 0.477 0 0
Inhibition of membrane repair R-HSA-9635644 3.338053e-01 0.477 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.371862e-01 0.472 0 0
DARPP-32 events R-HSA-180024 3.381681e-01 0.471 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.381681e-01 0.471 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.433212e-01 0.464 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.433212e-01 0.464 0 0
Oncogene Induced Senescence R-HSA-2559585 3.433212e-01 0.464 0 0
STAT5 Activation R-HSA-9645135 3.440370e-01 0.463 0 0
Autointegration results in viral DNA circles R-HSA-177539 3.440370e-01 0.463 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.440370e-01 0.463 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 3.440370e-01 0.463 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.440370e-01 0.463 0 0
Neurofascin interactions R-HSA-447043 3.440370e-01 0.463 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.440370e-01 0.463 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 3.440370e-01 0.463 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.479092e-01 0.459 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.479092e-01 0.459 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.483651e-01 0.458 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.483651e-01 0.458 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.483651e-01 0.458 0 0
Co-stimulation by CD28 R-HSA-389356 3.491110e-01 0.457 0 0
Gluconeogenesis R-HSA-70263 3.491110e-01 0.457 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.491904e-01 0.457 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.491904e-01 0.457 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.521792e-01 0.453 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.618519e-01 0.441 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.649774e-01 0.438 0 0
RNA Polymerase III Transcription R-HSA-74158 3.649774e-01 0.438 0 0
GPVI-mediated activation cascade R-HSA-114604 3.649774e-01 0.438 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.668463e-01 0.436 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.668463e-01 0.436 0 0
DNA Damage Bypass R-HSA-73893 3.678876e-01 0.434 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.681932e-01 0.434 0 0
Polymerase switching R-HSA-69091 3.681932e-01 0.434 0 0
Leading Strand Synthesis R-HSA-69109 3.681932e-01 0.434 0 0
Interleukin-35 Signalling R-HSA-8984722 3.681932e-01 0.434 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 3.681932e-01 0.434 0 0
PKA activation R-HSA-163615 3.782431e-01 0.422 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.782431e-01 0.422 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.782431e-01 0.422 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.782431e-01 0.422 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.782431e-01 0.422 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.805548e-01 0.420 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.818704e-01 0.418 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 3.831591e-01 0.417 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.831591e-01 0.417 0 0
Neurodegenerative Diseases R-HSA-8863678 3.831591e-01 0.417 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.831591e-01 0.417 0 0
Downstream signal transduction R-HSA-186763 3.856211e-01 0.414 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.857032e-01 0.414 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.857032e-01 0.414 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.861546e-01 0.413 0 0
Activation of TRKA receptors R-HSA-187015 3.921478e-01 0.407 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.921478e-01 0.407 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.921478e-01 0.407 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.921478e-01 0.407 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.921478e-01 0.407 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.921478e-01 0.407 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.921478e-01 0.407 0 0
Disinhibition of SNARE formation R-HSA-114516 3.921478e-01 0.407 0 0
DAG1 core M1 glycosylations R-HSA-8932506 3.921478e-01 0.407 0 0
PTK6 Expression R-HSA-8849473 3.921478e-01 0.407 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.921478e-01 0.407 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.921478e-01 0.407 0 0
CHL1 interactions R-HSA-447041 3.921478e-01 0.407 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.921478e-01 0.407 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.921478e-01 0.407 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.921478e-01 0.407 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.004306e-01 0.397 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.010185e-01 0.397 0 0
Formation of axial mesoderm R-HSA-9796292 4.043837e-01 0.393 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 4.043837e-01 0.393 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 4.043837e-01 0.393 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.043837e-01 0.393 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.084303e-01 0.389 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 4.084969e-01 0.389 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.093863e-01 0.388 0 0
Signaling by WNT in cancer R-HSA-4791275 4.093863e-01 0.388 0 0
Interleukin-7 signaling R-HSA-1266695 4.095747e-01 0.388 0 0
HDMs demethylate histones R-HSA-3214842 4.095747e-01 0.388 0 0
TGFBR3 expression R-HSA-9839394 4.095747e-01 0.388 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.181725e-01 0.379 0 0
Signalling to ERK5 R-HSA-198765 4.181725e-01 0.379 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.181725e-01 0.379 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.181725e-01 0.379 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.181725e-01 0.379 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.181725e-01 0.379 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.181725e-01 0.379 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.181725e-01 0.379 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.181725e-01 0.379 0 0
DSCAM interactions R-HSA-376172 4.181725e-01 0.379 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.246078e-01 0.372 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.246078e-01 0.372 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.273947e-01 0.369 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.328235e-01 0.364 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.330631e-01 0.363 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.330631e-01 0.363 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.358251e-01 0.361 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.358251e-01 0.361 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.383085e-01 0.358 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.383085e-01 0.358 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.385973e-01 0.358 0 0
phospho-PLA2 pathway R-HSA-111995 4.385973e-01 0.358 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.385973e-01 0.358 0 0
DAG1 core M2 glycosylations R-HSA-8932504 4.385973e-01 0.358 0 0
Interleukin-23 signaling R-HSA-9020933 4.385973e-01 0.358 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.385973e-01 0.358 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 4.385973e-01 0.358 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.399425e-01 0.357 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.399425e-01 0.357 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.399425e-01 0.357 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.399425e-01 0.357 0 0
Signal regulatory protein family interactions R-HSA-391160 4.399425e-01 0.357 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.475159e-01 0.349 0 0
Glycogen metabolism R-HSA-8982491 4.518477e-01 0.345 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.565720e-01 0.340 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.575367e-01 0.340 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.618063e-01 0.336 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.618063e-01 0.336 0 0
Insulin processing R-HSA-264876 4.618063e-01 0.336 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.618063e-01 0.336 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.675228e-01 0.330 0 0
ERK/MAPK targets R-HSA-198753 4.677330e-01 0.330 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.677330e-01 0.330 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.677330e-01 0.330 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.677330e-01 0.330 0 0
G-protein activation R-HSA-202040 4.677330e-01 0.330 0 0
Signalling to RAS R-HSA-167044 4.677330e-01 0.330 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.677330e-01 0.330 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.677330e-01 0.330 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 4.677330e-01 0.330 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.746524e-01 0.324 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 4.746524e-01 0.324 0 0
G beta:gamma signalling through BTK R-HSA-8964315 4.746524e-01 0.324 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.746524e-01 0.324 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 4.746524e-01 0.324 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.746524e-01 0.324 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.746524e-01 0.324 0 0
Biotin transport and metabolism R-HSA-196780 4.746524e-01 0.324 0 0
Heme signaling R-HSA-9707616 4.752515e-01 0.323 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.762399e-01 0.322 0 0
eNOS activation R-HSA-203615 4.798395e-01 0.319 0 0
ARMS-mediated activation R-HSA-170984 4.830348e-01 0.316 0 0
WNT mediated activation of DVL R-HSA-201688 4.830348e-01 0.316 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.830348e-01 0.316 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.830348e-01 0.316 0 0
mRNA Editing R-HSA-75072 4.830348e-01 0.316 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.830348e-01 0.316 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.830348e-01 0.316 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.830348e-01 0.316 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.830348e-01 0.316 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.830348e-01 0.316 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 4.830348e-01 0.316 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.830348e-01 0.316 0 0
NGF-stimulated transcription R-HSA-9031628 4.873691e-01 0.312 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.874233e-01 0.312 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.874233e-01 0.312 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.874233e-01 0.312 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.918597e-01 0.308 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.918597e-01 0.308 0 0
Axonal growth stimulation R-HSA-209563 4.918597e-01 0.308 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 4.918597e-01 0.308 0 0
Signalling to STAT3 R-HSA-198745 4.918597e-01 0.308 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.918597e-01 0.308 0 0
Classical Kir channels R-HSA-1296053 4.918597e-01 0.308 0 0
Defective ABCC2 causes DJS R-HSA-5679001 4.918597e-01 0.308 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.918597e-01 0.308 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.918597e-01 0.308 0 0
MET activates STAT3 R-HSA-8875791 4.918597e-01 0.308 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.918597e-01 0.308 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.918597e-01 0.308 0 0
Histamine receptors R-HSA-390650 4.918597e-01 0.308 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.918597e-01 0.308 0 0
FasL/ CD95L signaling R-HSA-75157 4.918597e-01 0.308 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.926254e-01 0.307 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.928467e-01 0.307 0 0
Intra-Golgi traffic R-HSA-6811438 4.945416e-01 0.306 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.945416e-01 0.306 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.965769e-01 0.304 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.965769e-01 0.304 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.066702e-01 0.295 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.083356e-01 0.294 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.083356e-01 0.294 0 0
Killing mechanisms R-HSA-9664420 5.083356e-01 0.294 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.083356e-01 0.294 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.083356e-01 0.294 0 0
Atorvastatin ADME R-HSA-9754706 5.083356e-01 0.294 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.083356e-01 0.294 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.094569e-01 0.293 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.125914e-01 0.290 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.125914e-01 0.290 0 0
Signaling by Insulin receptor R-HSA-74752 5.154117e-01 0.288 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.218134e-01 0.282 0 0
Signaling by KIT in disease R-HSA-9669938 5.247308e-01 0.280 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.247308e-01 0.280 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.247308e-01 0.280 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.247308e-01 0.280 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.247308e-01 0.280 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.247308e-01 0.280 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.247308e-01 0.280 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.251126e-01 0.280 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.252250e-01 0.280 0 0
PI3K/AKT activation R-HSA-198203 5.252250e-01 0.280 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.252250e-01 0.280 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.264082e-01 0.279 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.372351e-01 0.270 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.372351e-01 0.270 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.372351e-01 0.270 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.408503e-01 0.267 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.408503e-01 0.267 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.521021e-01 0.258 0 0
Interleukin-20 family signaling R-HSA-8854691 5.521021e-01 0.258 0 0
Regulation of beta-cell development R-HSA-186712 5.538725e-01 0.257 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.562182e-01 0.255 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.562182e-01 0.255 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.562182e-01 0.255 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.562182e-01 0.255 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.562182e-01 0.255 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.562182e-01 0.255 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.562182e-01 0.255 0 0
Regulation of gap junction activity R-HSA-191650 5.562182e-01 0.255 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.562182e-01 0.255 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.562182e-01 0.255 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.562182e-01 0.255 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.562182e-01 0.255 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.562182e-01 0.255 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.562182e-01 0.255 0 0
RMTs methylate histone arginines R-HSA-3214858 5.564339e-01 0.255 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.585421e-01 0.253 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.612886e-01 0.251 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.643204e-01 0.248 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.650245e-01 0.248 0 0
Formation of the posterior neural plate R-HSA-9832991 5.650245e-01 0.248 0 0
Chylomicron assembly R-HSA-8963888 5.650245e-01 0.248 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 5.650245e-01 0.248 0 0
vRNP Assembly R-HSA-192905 5.650245e-01 0.248 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.650245e-01 0.248 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.650245e-01 0.248 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.650245e-01 0.248 0 0
Dissolution of Fibrin Clot R-HSA-75205 5.650245e-01 0.248 0 0
Neddylation R-HSA-8951664 5.678894e-01 0.246 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.720877e-01 0.243 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.720877e-01 0.243 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.720877e-01 0.243 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.720877e-01 0.243 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.763152e-01 0.239 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.786141e-01 0.238 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.786141e-01 0.238 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.786141e-01 0.238 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.903932e-01 0.229 0 0
RAS processing R-HSA-9648002 5.903932e-01 0.229 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.957606e-01 0.225 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.990344e-01 0.223 0 0
Rab regulation of trafficking R-HSA-9007101 6.017966e-01 0.221 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.019678e-01 0.220 0 0
Platelet sensitization by LDL R-HSA-432142 6.019678e-01 0.220 0 0
Mismatch Repair R-HSA-5358508 6.019678e-01 0.220 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.019678e-01 0.220 0 0
PKA activation in glucagon signalling R-HSA-164378 6.019678e-01 0.220 0 0
Tie2 Signaling R-HSA-210993 6.019678e-01 0.220 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.023620e-01 0.220 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.023620e-01 0.220 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 6.023620e-01 0.220 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.023620e-01 0.220 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.023620e-01 0.220 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.023620e-01 0.220 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.023620e-01 0.220 0 0
Sodium/Calcium exchangers R-HSA-425561 6.023620e-01 0.220 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.023620e-01 0.220 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.042052e-01 0.219 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.042052e-01 0.219 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.042052e-01 0.219 0 0
G protein gated Potassium channels R-HSA-1296059 6.042052e-01 0.219 0 0
Laminin interactions R-HSA-3000157 6.042052e-01 0.219 0 0
Nuclear RNA decay R-HSA-9930044 6.074082e-01 0.217 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.110003e-01 0.214 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.110003e-01 0.214 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.110003e-01 0.214 0 0
HIV Transcription Elongation R-HSA-167169 6.110003e-01 0.214 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.110003e-01 0.214 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.124287e-01 0.213 0 0
G2 Phase R-HSA-68911 6.124287e-01 0.213 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.124287e-01 0.213 0 0
Activation of AKT2 R-HSA-165158 6.124287e-01 0.213 0 0
PTK6 Down-Regulation R-HSA-8849472 6.124287e-01 0.213 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.124287e-01 0.213 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.124287e-01 0.213 0 0
Reelin signalling pathway R-HSA-8866376 6.124287e-01 0.213 0 0
NrCAM interactions R-HSA-447038 6.124287e-01 0.213 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.124287e-01 0.213 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.124287e-01 0.213 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.124287e-01 0.213 0 0
Integrin cell surface interactions R-HSA-216083 6.147040e-01 0.211 0 0
G alpha (z) signalling events R-HSA-418597 6.185125e-01 0.209 0 0
Paracetamol ADME R-HSA-9753281 6.185125e-01 0.209 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.222623e-01 0.206 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.230333e-01 0.205 0 0
MET activates PTK2 signaling R-HSA-8874081 6.288276e-01 0.201 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.293877e-01 0.201 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.304366e-01 0.200 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.304366e-01 0.200 0 0
The NLRP3 inflammasome R-HSA-844456 6.304366e-01 0.200 0 0
Other interleukin signaling R-HSA-449836 6.304366e-01 0.200 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.372226e-01 0.196 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.372226e-01 0.196 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.372226e-01 0.196 0 0
Translation of Structural Proteins R-HSA-9683701 6.504207e-01 0.187 0 0
Signal amplification R-HSA-392518 6.506030e-01 0.187 0 0
Gap junction assembly R-HSA-190861 6.506030e-01 0.187 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.524462e-01 0.185 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.524462e-01 0.185 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.524462e-01 0.185 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.524462e-01 0.185 0 0
IRS-mediated signalling R-HSA-112399 6.525620e-01 0.185 0 0
Protein hydroxylation R-HSA-9629569 6.574622e-01 0.182 0 0
NGF-independant TRKA activation R-HSA-187024 6.615223e-01 0.179 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.615223e-01 0.179 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.615223e-01 0.179 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.615223e-01 0.179 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.615223e-01 0.179 0 0
Signaling by MAPK mutants R-HSA-9652817 6.615223e-01 0.179 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.615223e-01 0.179 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.615223e-01 0.179 0 0
Signaling by MST1 R-HSA-8852405 6.615223e-01 0.179 0 0
Cam-PDE 1 activation R-HSA-111957 6.615223e-01 0.179 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.615223e-01 0.179 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.615223e-01 0.179 0 0
Relaxin receptors R-HSA-444821 6.615223e-01 0.179 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.615223e-01 0.179 0 0
VEGF ligand-receptor interactions R-HSA-194313 6.615223e-01 0.179 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.615223e-01 0.179 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.615223e-01 0.179 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.615223e-01 0.179 0 0
Developmental Cell Lineages R-HSA-9734767 6.690920e-01 0.175 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.696348e-01 0.174 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.696348e-01 0.174 0 0
PERK regulates gene expression R-HSA-381042 6.710307e-01 0.173 0 0
HIV elongation arrest and recovery R-HSA-167287 6.750373e-01 0.171 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.750373e-01 0.171 0 0
Pyroptosis R-HSA-5620971 6.750373e-01 0.171 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.750373e-01 0.171 0 0
Integration of energy metabolism R-HSA-163685 6.774429e-01 0.169 0 0
Lagging Strand Synthesis R-HSA-69186 6.830322e-01 0.166 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.830322e-01 0.166 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.830322e-01 0.166 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.851855e-01 0.164 0 0
TBC/RABGAPs R-HSA-8854214 6.872993e-01 0.163 0 0
RUNX2 regulates bone development R-HSA-8941326 6.906541e-01 0.161 0 0
mRNA Capping R-HSA-72086 6.965878e-01 0.157 0 0
Glucagon-type ligand receptors R-HSA-420092 6.965878e-01 0.157 0 0
Transcription of the HIV genome R-HSA-167172 6.993135e-01 0.155 0 0
Removal of the Flap Intermediate R-HSA-69166 6.996594e-01 0.155 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.996594e-01 0.155 0 0
Acyl chain remodeling of CL R-HSA-1482798 6.996594e-01 0.155 0 0
Zinc transporters R-HSA-435354 6.996594e-01 0.155 0 0
HDL assembly R-HSA-8963896 6.996594e-01 0.155 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.027064e-01 0.153 0 0
Chylomicron clearance R-HSA-8964026 7.043997e-01 0.152 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.043997e-01 0.152 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.043997e-01 0.152 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.043997e-01 0.152 0 0
MET Receptor Activation R-HSA-6806942 7.043997e-01 0.152 0 0
CREB phosphorylation R-HSA-199920 7.043997e-01 0.152 0 0
Abacavir transmembrane transport R-HSA-2161517 7.043997e-01 0.152 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 7.043997e-01 0.152 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.043997e-01 0.152 0 0
Metabolism of vitamin K R-HSA-6806664 7.043997e-01 0.152 0 0
HDL clearance R-HSA-8964011 7.043997e-01 0.152 0 0
Nef and signal transduction R-HSA-164944 7.043997e-01 0.152 0 0
VLDL assembly R-HSA-8866423 7.043997e-01 0.152 0 0
Netrin-1 signaling R-HSA-373752 7.047476e-01 0.152 0 0
Cyclin D associated events in G1 R-HSA-69231 7.047476e-01 0.152 0 0
G1 Phase R-HSA-69236 7.047476e-01 0.152 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.071503e-01 0.150 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.071503e-01 0.150 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.170937e-01 0.144 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.215238e-01 0.142 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.273812e-01 0.138 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.273812e-01 0.138 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.273812e-01 0.138 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.273812e-01 0.138 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.273812e-01 0.138 0 0
Formation of the anterior neural plate R-HSA-9823739 7.273812e-01 0.138 0 0
Elastic fibre formation R-HSA-1566948 7.274532e-01 0.138 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.274532e-01 0.138 0 0
Signaling by PDGF R-HSA-186797 7.294545e-01 0.137 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.298341e-01 0.137 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.298341e-01 0.137 0 0
LDL clearance R-HSA-8964038 7.298341e-01 0.137 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.353168e-01 0.134 0 0
Innate Immune System R-HSA-168249 7.363206e-01 0.133 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.383625e-01 0.132 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.418477e-01 0.130 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.418477e-01 0.130 0 0
Netrin mediated repulsion signals R-HSA-418886 7.418477e-01 0.130 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.418477e-01 0.130 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.418477e-01 0.130 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.418477e-01 0.130 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.418477e-01 0.130 0 0
VLDL clearance R-HSA-8964046 7.418477e-01 0.130 0 0
LDL remodeling R-HSA-8964041 7.418477e-01 0.130 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.418477e-01 0.130 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.418477e-01 0.130 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.418477e-01 0.130 0 0
Pentose phosphate pathway R-HSA-71336 7.446251e-01 0.128 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.511123e-01 0.124 0 0
Differentiation of T cells R-HSA-9945266 7.529015e-01 0.123 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.529015e-01 0.123 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.529015e-01 0.123 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.529015e-01 0.123 0 0
Activation of SMO R-HSA-5635838 7.529015e-01 0.123 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.529015e-01 0.123 0 0
Virus Assembly and Release R-HSA-168268 7.529015e-01 0.123 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 7.549947e-01 0.122 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.549947e-01 0.122 0 0
Ion transport by P-type ATPases R-HSA-936837 7.567416e-01 0.121 0 0
Infectious disease R-HSA-5663205 7.608304e-01 0.119 0 0
Ion homeostasis R-HSA-5578775 7.614411e-01 0.118 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.614411e-01 0.118 0 0
Transmission across Chemical Synapses R-HSA-112315 7.645783e-01 0.117 0 0
Toll-like Receptor Cascades R-HSA-168898 7.667463e-01 0.115 0 0
Intraflagellar transport R-HSA-5620924 7.678028e-01 0.115 0 0
Metal ion SLC transporters R-HSA-425410 7.678028e-01 0.115 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.710226e-01 0.113 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.710226e-01 0.113 0 0
Regulation by c-FLIP R-HSA-3371378 7.745535e-01 0.111 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.745535e-01 0.111 0 0
Dimerization of procaspase-8 R-HSA-69416 7.745535e-01 0.111 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.745535e-01 0.111 0 0
Interleukin-9 signaling R-HSA-8985947 7.745535e-01 0.111 0 0
Co-stimulation by ICOS R-HSA-9927354 7.745535e-01 0.111 0 0
Activation of RAS in B cells R-HSA-1169092 7.745535e-01 0.111 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.745535e-01 0.111 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.745535e-01 0.111 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.745535e-01 0.111 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.745535e-01 0.111 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.745535e-01 0.111 0 0
Alpha-defensins R-HSA-1462054 7.745535e-01 0.111 0 0
Sodium/Proton exchangers R-HSA-425986 7.745535e-01 0.111 0 0
Mitochondrial biogenesis R-HSA-1592230 7.750876e-01 0.111 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.763333e-01 0.110 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.763333e-01 0.110 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 7.763333e-01 0.110 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.763333e-01 0.110 0 0
tRNA modification in the mitochondrion R-HSA-6787450 7.763333e-01 0.110 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.851591e-01 0.105 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.888511e-01 0.103 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.888511e-01 0.103 0 0
Iron uptake and transport R-HSA-917937 7.890272e-01 0.103 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.892170e-01 0.103 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.896100e-01 0.103 0 0
Formation of the nephric duct R-HSA-9830364 7.896100e-01 0.103 0 0
Parasite infection R-HSA-9664407 7.902063e-01 0.102 0 0
Leishmania phagocytosis R-HSA-9664417 7.902063e-01 0.102 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.902063e-01 0.102 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.913064e-01 0.102 0 0
PI3K Cascade R-HSA-109704 7.953205e-01 0.099 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.977960e-01 0.098 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.977960e-01 0.098 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.977960e-01 0.098 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.977960e-01 0.098 0 0
Specification of primordial germ cells R-HSA-9827857 7.977960e-01 0.098 0 0
Extension of Telomeres R-HSA-180786 8.001225e-01 0.097 0 0
CASP8 activity is inhibited R-HSA-5218900 8.031174e-01 0.095 0 0
Interleukin-21 signaling R-HSA-9020958 8.031174e-01 0.095 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.031174e-01 0.095 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.031174e-01 0.095 0 0
Interleukin-1 processing R-HSA-448706 8.031174e-01 0.095 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 8.031174e-01 0.095 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.031174e-01 0.095 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.031174e-01 0.095 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.031174e-01 0.095 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.031174e-01 0.095 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.043201e-01 0.095 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.052985e-01 0.094 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.069249e-01 0.093 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.069249e-01 0.093 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.069249e-01 0.093 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.174124e-01 0.088 0 0
GAB1 signalosome R-HSA-180292 8.174124e-01 0.088 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.174124e-01 0.088 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.174124e-01 0.088 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.174124e-01 0.088 0 0
Polo-like kinase mediated events R-HSA-156711 8.174124e-01 0.088 0 0
Nephron development R-HSA-9831926 8.174124e-01 0.088 0 0
Interferon gamma signaling R-HSA-877300 8.191920e-01 0.087 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.230219e-01 0.085 0 0
Signaling by BMP R-HSA-201451 8.230219e-01 0.085 1 1
Aquaporin-mediated transport R-HSA-445717 8.231304e-01 0.085 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.280637e-01 0.082 0 0
Binding and entry of HIV virion R-HSA-173107 8.280637e-01 0.082 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.280637e-01 0.082 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.280637e-01 0.082 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.280637e-01 0.082 0 0
Maturation of spike protein R-HSA-9683686 8.280637e-01 0.082 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.287222e-01 0.082 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.317915e-01 0.080 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.324884e-01 0.080 0 0
G1/S-Specific Transcription R-HSA-69205 8.324884e-01 0.080 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.353056e-01 0.078 0 0
Specification of the neural plate border R-HSA-9834899 8.353056e-01 0.078 0 0
Maturation of nucleoprotein R-HSA-9694631 8.353056e-01 0.078 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.353056e-01 0.078 0 0
Insulin receptor recycling R-HSA-77387 8.379581e-01 0.077 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.379581e-01 0.077 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.379581e-01 0.077 0 0
Inflammasomes R-HSA-622312 8.379581e-01 0.077 0 0
Leishmania infection R-HSA-9658195 8.385532e-01 0.076 0 0
Parasitic Infection Pathways R-HSA-9824443 8.385532e-01 0.076 0 0
tRNA processing R-HSA-72306 8.447031e-01 0.073 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.498504e-01 0.071 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.498504e-01 0.071 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.498504e-01 0.071 0 0
vRNA Synthesis R-HSA-192814 8.498504e-01 0.071 0 0
Bicarbonate transporters R-HSA-425381 8.498504e-01 0.071 0 0
LGI-ADAM interactions R-HSA-5682910 8.498504e-01 0.071 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.498504e-01 0.071 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.498504e-01 0.071 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.515973e-01 0.070 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.515973e-01 0.070 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.515973e-01 0.070 0 0
Creatine metabolism R-HSA-71288 8.515973e-01 0.070 0 0
Platelet calcium homeostasis R-HSA-418360 8.517924e-01 0.070 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.539347e-01 0.069 0 0
Signaling by TGFBR3 R-HSA-9839373 8.539347e-01 0.069 0 0
Ca2+ pathway R-HSA-4086398 8.552302e-01 0.068 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.552302e-01 0.068 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.643776e-01 0.063 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.645846e-01 0.063 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.664060e-01 0.062 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.664060e-01 0.062 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.664060e-01 0.062 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.683315e-01 0.061 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.688776e-01 0.061 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.688776e-01 0.061 0 0
Regulation of insulin secretion R-HSA-422356 8.700474e-01 0.060 0 0
Synthesis of PA R-HSA-1483166 8.720960e-01 0.059 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.763941e-01 0.057 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.798459e-01 0.056 0 0
Attachment and Entry R-HSA-9694614 8.798459e-01 0.056 0 0
Glutathione synthesis and recycling R-HSA-174403 8.798459e-01 0.056 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.810824e-01 0.055 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.842205e-01 0.053 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.854945e-01 0.053 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.854945e-01 0.053 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 8.854945e-01 0.053 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.854945e-01 0.053 0 0
Acetylation R-HSA-156582 8.854945e-01 0.053 0 0
Proline catabolism R-HSA-70688 8.854945e-01 0.053 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.854945e-01 0.053 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.854945e-01 0.053 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.854945e-01 0.053 0 0
OAS antiviral response R-HSA-8983711 8.854945e-01 0.053 0 0
Stimuli-sensing channels R-HSA-2672351 8.856179e-01 0.053 0 0
Translation of Structural Proteins R-HSA-9694635 8.872835e-01 0.052 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.886870e-01 0.051 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.920260e-01 0.050 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.920260e-01 0.050 0 0
Cellular hexose transport R-HSA-189200 8.920260e-01 0.050 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.950610e-01 0.048 0 0
tRNA Aminoacylation R-HSA-379724 8.967360e-01 0.047 0 0
Cardiogenesis R-HSA-9733709 8.973003e-01 0.047 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 9.000065e-01 0.046 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.000065e-01 0.046 0 0
Chylomicron remodeling R-HSA-8963901 9.000065e-01 0.046 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 9.000065e-01 0.046 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 9.000065e-01 0.046 0 0
Processing of SMDT1 R-HSA-8949664 9.000065e-01 0.046 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 9.000065e-01 0.046 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.000065e-01 0.046 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.000065e-01 0.046 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 9.000065e-01 0.046 0 0
Maturation of nucleoprotein R-HSA-9683610 9.000065e-01 0.046 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.000065e-01 0.046 0 0
The phototransduction cascade R-HSA-2514856 9.000612e-01 0.046 0 0
Pyruvate metabolism R-HSA-70268 9.007573e-01 0.045 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.030497e-01 0.044 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.030497e-01 0.044 0 0
Formation of the ureteric bud R-HSA-9830674 9.030497e-01 0.044 0 0
Biosynthesis of maresins R-HSA-9018682 9.030497e-01 0.044 0 0
Activation of GABAB receptors R-HSA-991365 9.057124e-01 0.043 0 0
GABA B receptor activation R-HSA-977444 9.057124e-01 0.043 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.065112e-01 0.043 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.065112e-01 0.043 0 0
Mitochondrial protein import R-HSA-1268020 9.108059e-01 0.041 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.108059e-01 0.041 0 0
Prolactin receptor signaling R-HSA-1170546 9.126800e-01 0.040 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.126800e-01 0.040 0 0
Hydrolysis of LPC R-HSA-1483115 9.126800e-01 0.040 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 9.126800e-01 0.040 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 9.126800e-01 0.040 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 9.126800e-01 0.040 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 9.126800e-01 0.040 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 9.126800e-01 0.040 0 0
P2Y receptors R-HSA-417957 9.126800e-01 0.040 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.126800e-01 0.040 0 0
RSV-host interactions R-HSA-9833110 9.127148e-01 0.040 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.130143e-01 0.040 0 0
Complex III assembly R-HSA-9865881 9.130143e-01 0.040 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.149671e-01 0.039 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.194648e-01 0.036 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.220113e-01 0.035 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.220113e-01 0.035 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.220113e-01 0.035 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.220113e-01 0.035 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.220113e-01 0.035 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.227205e-01 0.035 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.237479e-01 0.034 0 0
Protein lipoylation R-HSA-9857492 9.237479e-01 0.034 0 0
p38MAPK events R-HSA-171007 9.237479e-01 0.034 0 0
Transport and metabolism of PAPS R-HSA-174362 9.237479e-01 0.034 0 0
Other semaphorin interactions R-HSA-416700 9.237479e-01 0.034 0 0
DNA Damage Reversal R-HSA-73942 9.237479e-01 0.034 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.250091e-01 0.034 0 0
Triglyceride catabolism R-HSA-163560 9.298213e-01 0.032 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.298213e-01 0.032 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.301258e-01 0.031 0 0
TRP channels R-HSA-3295583 9.301258e-01 0.031 0 0
Adipogenesis R-HSA-9843745 9.320159e-01 0.031 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.324833e-01 0.030 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.333644e-01 0.030 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.333644e-01 0.030 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.334135e-01 0.030 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.334135e-01 0.030 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.334135e-01 0.030 0 0
Fructose catabolism R-HSA-70350 9.334135e-01 0.030 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.334135e-01 0.030 0 0
Attachment and Entry R-HSA-9678110 9.334135e-01 0.030 0 0
Voltage gated Potassium channels R-HSA-1296072 9.363173e-01 0.029 0 0
Cristae formation R-HSA-8949613 9.374368e-01 0.028 0 0
Kidney development R-HSA-9830369 9.389195e-01 0.027 0 0
Synthesis of PC R-HSA-1483191 9.390179e-01 0.027 0 0
SLC transporter disorders R-HSA-5619102 9.415768e-01 0.026 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.418543e-01 0.026 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.418543e-01 0.026 0 0
Glycine degradation R-HSA-6783984 9.418543e-01 0.026 0 0
Phase 2 - plateau phase R-HSA-5576893 9.418543e-01 0.026 0 0
Fibronectin matrix formation R-HSA-1566977 9.418543e-01 0.026 0 0
Heme assimilation R-HSA-9927020 9.418543e-01 0.026 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.418543e-01 0.026 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.418543e-01 0.026 0 0
Passive transport by Aquaporins R-HSA-432047 9.418543e-01 0.026 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.418543e-01 0.026 0 0
Coenzyme A biosynthesis R-HSA-196783 9.418543e-01 0.026 0 0
Purine salvage R-HSA-74217 9.422536e-01 0.026 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.422536e-01 0.026 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.431565e-01 0.025 0 0
Telomere Extension By Telomerase R-HSA-171319 9.440177e-01 0.025 0 0
Prednisone ADME R-HSA-9757110 9.440177e-01 0.025 0 0
Neuronal System R-HSA-112316 9.472095e-01 0.024 0 0
Peroxisomal protein import R-HSA-9033241 9.477064e-01 0.023 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.477064e-01 0.023 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.492256e-01 0.023 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.492256e-01 0.023 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.492256e-01 0.023 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.492256e-01 0.023 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.492256e-01 0.023 0 0
Choline catabolism R-HSA-6798163 9.492256e-01 0.023 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.492256e-01 0.023 0 0
COPII-mediated vesicle transport R-HSA-204005 9.517180e-01 0.021 0 0
RAB geranylgeranylation R-HSA-8873719 9.519236e-01 0.021 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.526155e-01 0.021 0 0
Diseases of Immune System R-HSA-5260271 9.526155e-01 0.021 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.526155e-01 0.021 0 0
Azathioprine ADME R-HSA-9748787 9.534546e-01 0.021 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.552540e-01 0.020 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.556628e-01 0.020 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.556628e-01 0.020 0 0
Ion channel transport R-HSA-983712 9.559489e-01 0.020 0 0
Cardiac conduction R-HSA-5576891 9.598624e-01 0.018 0 0
Formation of the cornified envelope R-HSA-6809371 9.603849e-01 0.018 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.611409e-01 0.017 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.612188e-01 0.017 0 0
HIV Transcription Initiation R-HSA-167161 9.612188e-01 0.017 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.612188e-01 0.017 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.612188e-01 0.017 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.612842e-01 0.017 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.612842e-01 0.017 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.612842e-01 0.017 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.612842e-01 0.017 0 0
HDL remodeling R-HSA-8964058 9.612842e-01 0.017 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.612842e-01 0.017 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.612842e-01 0.017 0 0
Aspirin ADME R-HSA-9749641 9.620456e-01 0.017 0 0
DAG1 glycosylations R-HSA-8931838 9.643122e-01 0.016 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.661932e-01 0.015 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.661932e-01 0.015 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.661932e-01 0.015 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.661932e-01 0.015 0 0
Recycling of bile acids and salts R-HSA-159418 9.681524e-01 0.014 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.683369e-01 0.014 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.704800e-01 0.013 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.704800e-01 0.013 0 0
Heme degradation R-HSA-189483 9.715929e-01 0.013 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.737658e-01 0.012 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.742072e-01 0.011 0 0
Ribavirin ADME R-HSA-9755088 9.742234e-01 0.011 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.742234e-01 0.011 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.746732e-01 0.011 0 0
Hyaluronan metabolism R-HSA-2142845 9.746732e-01 0.011 0 0
Interleukin-10 signaling R-HSA-6783783 9.748766e-01 0.011 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.762049e-01 0.010 0 0
Extracellular matrix organization R-HSA-1474244 9.762312e-01 0.010 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.774293e-01 0.010 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.774923e-01 0.010 0 0
Fructose metabolism R-HSA-5652084 9.774923e-01 0.010 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.774923e-01 0.010 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.774923e-01 0.010 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.779674e-01 0.010 0 0
Platelet homeostasis R-HSA-418346 9.780610e-01 0.010 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.798736e-01 0.009 0 0
Triglyceride metabolism R-HSA-8979227 9.799845e-01 0.009 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.799845e-01 0.009 0 0
Post-translational protein modification R-HSA-597592 9.802096e-01 0.009 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.803468e-01 0.009 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.803468e-01 0.009 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.803468e-01 0.009 0 0
Carnitine shuttle R-HSA-200425 9.803468e-01 0.009 0 0
ECM proteoglycans R-HSA-3000178 9.816689e-01 0.008 0 0
Glutathione conjugation R-HSA-156590 9.818264e-01 0.008 0 0
GABA receptor activation R-HSA-977443 9.818264e-01 0.008 0 0
NCAM1 interactions R-HSA-419037 9.820966e-01 0.008 0 0
Metabolism of folate and pterines R-HSA-196757 9.820966e-01 0.008 0 0
CYP2E1 reactions R-HSA-211999 9.828395e-01 0.008 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.828395e-01 0.008 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.828395e-01 0.008 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.828395e-01 0.008 0 0
Tight junction interactions R-HSA-420029 9.850161e-01 0.007 0 0
Hyaluronan degradation R-HSA-2160916 9.850161e-01 0.007 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.850161e-01 0.007 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.858208e-01 0.006 0 0
Disease R-HSA-1643685 9.862377e-01 0.006 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.869167e-01 0.006 0 0
Urea cycle R-HSA-70635 9.869167e-01 0.006 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.869167e-01 0.006 0 0
Abacavir ADME R-HSA-2161522 9.869167e-01 0.006 0 0
Sphingolipid catabolism R-HSA-9845614 9.869167e-01 0.006 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.869167e-01 0.006 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.870457e-01 0.006 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.873883e-01 0.006 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.884270e-01 0.005 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.885764e-01 0.005 0 0
Triglyceride biosynthesis R-HSA-75109 9.885764e-01 0.005 0 0
Synthesis of PE R-HSA-1483213 9.885764e-01 0.005 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.885764e-01 0.005 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.887864e-01 0.005 0 0
Maturation of spike protein R-HSA-9694548 9.887864e-01 0.005 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.894514e-01 0.005 0 0
Potassium Channels R-HSA-1296071 9.896393e-01 0.005 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.900256e-01 0.004 0 0
Pyrimidine salvage R-HSA-73614 9.900256e-01 0.004 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.912581e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.912911e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.912911e-01 0.004 0 0
G alpha (s) signalling events R-HSA-418555 9.915567e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.917835e-01 0.004 0 0
Protein localization R-HSA-9609507 9.918133e-01 0.004 0 0
Surfactant metabolism R-HSA-5683826 9.930140e-01 0.003 0 0
Cargo concentration in the ER R-HSA-5694530 9.933608e-01 0.003 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.933608e-01 0.003 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.937982e-01 0.003 0 0
PI Metabolism R-HSA-1483255 9.938185e-01 0.003 0 0
HS-GAG degradation R-HSA-2024096 9.942033e-01 0.003 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.947825e-01 0.002 0 0
Nucleotide salvage R-HSA-8956321 9.953247e-01 0.002 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.955259e-01 0.002 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.955812e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.956681e-01 0.002 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.961060e-01 0.002 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.961420e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.961420e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.961585e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.961585e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.963056e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.963056e-01 0.002 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.966316e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.970362e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.970592e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.970592e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.970592e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.971083e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.972625e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.973042e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.973122e-01 0.001 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.974325e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.974325e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.974325e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.977584e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.980430e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.982834e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.982914e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.983209e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.983381e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.984665e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.984665e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.984665e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.985263e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.985431e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.985742e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.986305e-01 0.001 0 0
Purine catabolism R-HSA-74259 9.986305e-01 0.001 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.986977e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.986977e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.988631e-01 0.000 0 0
Defensins R-HSA-1461973 9.990075e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.990075e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.991072e-01 0.000 0 0
Amine ligand-binding receptors R-HSA-375280 9.991335e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.991608e-01 0.000 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.992436e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.992553e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.993088e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.993828e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.993828e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.994235e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.994604e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.995106e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.995178e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.996165e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.996207e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.996237e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.996652e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.996652e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.996652e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997407e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.997407e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.997773e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998216e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998303e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.998312e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.998871e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.998871e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.998944e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.999015e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999020e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999140e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999152e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999258e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999568e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999605e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999620e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999620e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999668e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999682e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999845e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999853e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999872e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999902e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999902e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999921e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999924e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999927e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999941e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999948e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999953e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999969e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999973e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999983e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999987e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999990e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999993e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999994e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999995e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999996e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999997e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999998e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways