CK1E
Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Motif clusters with count ≥ 10 are shown
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| substrate_uniprot | site | source | substrate_genes | site_seq |
|---|---|---|---|---|
| A5A3E0 | S1068 | Sugiyama | POTEF A26C1B | SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________ |
| O00170 | T48 | Sugiyama | AIP XAP2 | FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF |
| O00299 | S221 | Sugiyama | CLIC1 G6 NCC27 | EAFRGVHRYLsNAyAREEFAstCPDDEEIELAyEQVAKALK |
| O00299 | T222 | Sugiyama | CLIC1 G6 NCC27 | AFRGVHRYLsNAyAREEFAstCPDDEEIELAyEQVAKALK_ |
| O00505 | S60 | Sugiyama | KPNA3 QIP2 | KRDEHLLKKRNVPQEEsLEDsDVDADFKAQNVTLEAILQNA |
| O14640 | S139 | SIGNOR | DVL1 | sFHPNVAsSRDGMDNETGTEsMVsHRRERARRRNREEAART |
| O14640 | S142 | SIGNOR | DVL1 | PNVAsSRDGMDNETGTEsMVsHRRERARRRNREEAARTNGH |
| O14641 | S143 | SIGNOR|PSP | DVL2 | ERtsGIGDsRPPsFHPNVsssHENLEPEtEtEsVVsLRRER |
| O14641 | T224 | SIGNOR|PSP | DVL2 | EStSLGDsDEEDTMSRFSSStEQssASRLLKRHRRRRKQRP |
| O15055 | S480 | SIGNOR|PSP | PER2 KIAA0347 | QELTEQIHRLLLQPVPHSGSsGYGSLGSNGSHEHLMSQTSS |
| O15055 | S662 | ELM|iPTMNet|PSP | PER2 KIAA0347 | NSRTGVGTHLTSLALPGKAEsVAsLTsQCsYSsTIVHVGDK |
| O15055 | S665 | iPTMNet|PSP | PER2 KIAA0347 | TGVGTHLTSLALPGKAEsVAsLTsQCsYSsTIVHVGDKKPQ |
| O15055 | S668 | iPTMNet|PSP | PER2 KIAA0347 | GTHLTSLALPGKAEsVAsLTsQCsYSsTIVHVGDKKPQPEL |
| O15055 | S671 | iPTMNet | PER2 KIAA0347 | LTSLALPGKAEsVAsLTsQCsYSsTIVHVGDKKPQPELEMV |
| O15055 | S674 | iPTMNet | PER2 KIAA0347 | LALPGKAEsVAsLTsQCsYSsTIVHVGDKKPQPELEMVEDA |
| O43719 | S714 | Sugiyama | HTATSF1 | EKLFEDDDsNEKLFDEEEDssEKLFDDsDERGTLGGFGSVE |
| O43847 | S96 | Sugiyama | NRDC NRD1 | SRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYRYI |
| O43852 | S44 | Sugiyama | CALU | KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL |
| O60231 | S112 | Sugiyama | DHX16 DBP2 DDX16 KIAA0577 PRP2 | EKNRSYRLLEDsEEssEEtVsRAGsSLQKKRKKRKHLRKKR |
| O60231 | S116 | Sugiyama | DHX16 DBP2 DDX16 KIAA0577 PRP2 | SYRLLEDsEEssEEtVsRAGsSLQKKRKKRKHLRKKREEEE |
| O60353 | S648 | PSP | FZD6 | LsGEQVDGKGQAGsVSESARsEGRIsPKsDItDtGLAQSNN |
| O60664 | S93 | Sugiyama | PLIN3 M6PRBP1 TIP47 | AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP |
| O60716 | S268 | SIGNOR|PSP | CTNND1 KIAA0384 | yRAPsRQDVyGPQPQVRVGGssVDLHRFHPEPyGLEDDQRs |
| O60841 | S113 | Sugiyama | EIF5B IF2 KIAA0741 | sKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTAKPKVEM |
| O60841 | S222 | Sugiyama | EIF5B IF2 KIAA0741 | KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK |
| O75581 | S1420 | SIGNOR|PSP | LRP6 | PRMKGDGETMTNDYVVHGPAsVPLGYVPHPssLSGSLPGMS |
| O75581 | S1430 | SIGNOR | LRP6 | TNDYVVHGPAsVPLGYVPHPssLSGSLPGMSRGKSMISSLS |
| O75581 | S1431 | PSP | LRP6 | NDYVVHGPAsVPLGYVPHPssLSGSLPGMSRGKSMISSLSI |
| O75581 | S1490 | PSP | LRP6 | SSSSssTKGtYFPAILNPPPsPAtERsHYTMEFGYSsNsPs |
| O75943 | T681 | PSP | RAD17 R24L | FSAQGDMEENIIIEDyEsDGt____________________ |
| O95155 | S118 | Sugiyama | UBE4B HDNB1 KIAA0684 UFD2 | QsLsRsQsMDIDGVSCEKsMsQVDVDsGIENMEVDENDRRE |
| O95218 | S153 | Sugiyama | ZRANB2 ZIS ZNF265 | KYRGKAVGPAsILKEVEDKEsEGEEEDEDEDLsKyKLDEDE |
| O95218 | S181 | Sugiyama | ZRANB2 ZIS ZNF265 | DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR |
| O95863 | S104 | PSP | SNAI1 SNAH | RVAELTSLsDEDsGKGsQPPsPPsPAPsSFSsTSVsSLEAE |
| O95863 | S107 | PSP | SNAI1 SNAH | ELTSLsDEDsGKGsQPPsPPsPAPsSFSsTSVsSLEAEAYA |
| P00558 | S415 | Sugiyama | PGK1 PGKA MIG10 OK/SW-cl.110 | GGGAsLELLEGKVLPGVDALsNI__________________ |
| P04075 | S17 | Sugiyama | ALDOA ALDA | ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst |
| P04075 | S36 | Sugiyama | ALDOA ALDA | LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR |
| P04075 | S39 | Sugiyama | ALDOA ALDA | IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy |
| P04083 | S189 | Sugiyama | ANXA1 ANX1 LPC1 | tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA |
| P04083 | S201 | Sugiyama | ANXA1 ANX1 LPC1 | LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF |
| P04406 | S241 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV |
| P04406 | T237 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD |
| P04792 | S82 | Sugiyama | HSPB1 HSP27 HSP28 | AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN |
| P05187 | S434 | Sugiyama | ALPP PLAP | LYGNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDEETH |
| P05386 | S101 | Sugiyama | RPLP1 RRP1 | APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______ |
| P05386 | S104 | Sugiyama | RPLP1 RRP1 | tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________ |
| P05387 | S102 | Sugiyama | RPLP2 D11S2243E RPP2 | PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______ |
| P05387 | S105 | Sugiyama | RPLP2 D11S2243E RPP2 | GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________ |
| P05388 | S304 | Sugiyama | RPLP0 | AttAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______ |
| P05388 | S307 | Sugiyama | RPLP0 | AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________ |
| P05556 | S509 | Sugiyama | ITGB1 FNRB MDF2 MSK12 | CRCNEGRVGRHCECstDEVNsEDMDAYCRKENSSEICSNNG |
| P05787 | S258 | Sugiyama | KRT8 CYK8 | QISDTSVVLsMDNSRsLDMDsIIAEVKAQyEDIANRsRAEA |
| P06733 | S37 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY |
| P06733 | S40 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK |
| P06733 | T205 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE |
| P06733 | T41 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG |
| P06733 | Y44 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK |
| P07237 | S88 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG |
| P07237 | T85 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF |
| P07355 | S184 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK |
| P07737 | S28 | Sugiyama | PFN1 | IDNLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEV |
| P07737 | S30 | Sugiyama | PFN1 | NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV |
| P07900 | S263 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK |
| P07900 | S391 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV |
| P07900 | S505 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | KENQKHIyyItGETKDQVANsAFVERLRKHGLEVIyMIEPI |
| P07900 | T195 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG |
| P08235 | T800 | PSP | NR3C2 MCR MLR | VVKWAKVLPGFKNLPLEDQItLIQYSWMCLSSFALSWRSYK |
| P08238 | S383 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV |
| P08238 | S468 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG |
| P08238 | S470 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs |
| P08238 | S497 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI |
| P08238 | T190 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG |
| P08238 | T297 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA |
| P08238 | T467 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt |
| P08238 | Y301 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF |
| P08238 | Y472 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE |
| P08758 | S37 | Sugiyama | ANXA5 ANX5 ENX2 PP4 | ERADAEtLRKAMKGLGtDEEsILtLLtsRsNAQRQEISAAF |
| P08758 | T40 | Sugiyama | ANXA5 ANX5 ENX2 PP4 | DAEtLRKAMKGLGtDEEsILtLLtsRsNAQRQEISAAFKTL |
| P09104 | S37 | Sugiyama | ENO2 | NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY |
| P09104 | S40 | Sugiyama | ENO2 | VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK |
| P09104 | T41 | Sugiyama | ENO2 | EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG |
| P09104 | Y44 | Sugiyama | ENO2 | LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK |
| P09382 | T58 | Sugiyama | LGALS1 | DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF |
| P09972 | S132 | Sugiyama | ALDOC ALDC | GVVPLAGtDGEtttQGLDGLsERCAQYKKDGADFAKWRCVL |
| P0CG38 | S1068 | Sugiyama | POTEI | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0CG39 | S1031 | Sugiyama | POTEJ | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0DPH7 | S48 | Sugiyama | TUBA3C TUBA2 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P0DPH7 | S54 | Sugiyama | TUBA3C TUBA2 | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| P0DPH7 | T51 | Sugiyama | TUBA3C TUBA2 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| P10696 | S431 | Sugiyama | ALPG ALPPL ALPPL2 | LYGNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDGETH |
| P10809 | S488 | Sugiyama | HSPD1 HSP60 | IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG |
| P10809 | T422 | Sugiyama | HSPD1 HSP60 | AVLKVGGtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGC |
| P11047 | S942 | Sugiyama | LAMC1 LAMB2 | GFYNLQSGQGCERCDCHALGstNGQCDIRTGQCECQPGITG |
| P11142 | S221 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | GGGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHF |
| P11142 | S40 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P11142 | T45 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN |
| P11586 | T128 | Sugiyama | MTHFD1 MTHFC MTHFD | SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt |
| P12277 | S163 | Sugiyama | CKB CKBB | PPHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAE |
| P12830 | S844 | SIGNOR|PSP | CDH1 CDHE UVO | APPYDSLLVFDYEGsGsEAAsLSsLNssEsDKDQDYDYLNE |
| P13639 | S23 | Sugiyama | EEF2 EF2 | NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA |
| P13639 | S584 | Sugiyama | EEF2 EF2 | DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM |
| P13639 | S587 | Sugiyama | EEF2 EF2 | CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR |
| P13667 | S126 | Sugiyama | PDIA4 ERP70 ERP72 | NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG |
| P13667 | S468 | Sugiyama | PDIA4 ERP70 ERP72 | ytFAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAM |
| P13667 | S470 | Sugiyama | PDIA4 ERP70 ERP72 | FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP |
| P13929 | S37 | Sugiyama | ENO3 | NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY |
| P13929 | S40 | Sugiyama | ENO3 | VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK |
| P13929 | T41 | Sugiyama | ENO3 | EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG |
| P13929 | Y44 | Sugiyama | ENO3 | LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK |
| P14649 | S87 | Sugiyama | MYL6B MLC1SA | EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK |
| P15531 | S120 | Sugiyama | NME1 NDPKA NM23 | KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV |
| P17066 | S42 | Sugiyama | HSPA6 HSP70B' | VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA |
| P17066 | T47 | Sugiyama | HSPA6 HSP70B' | RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN |
| P18084 | S507 | Sugiyama | ITGB5 | CECSPGYLGTRCECQDGENQsVyQNLCREAEGKPLCSGRGD |
| P19338 | S458 | Sugiyama | NCL | TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN |
| P19338 | S619 | Sugiyama | NCL | RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK |
| P19338 | T452 | Sugiyama | NCL | AyIEFKTEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQD |
| P22314 | S46 | Sugiyama | UBA1 A1S9T UBE1 | AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA |
| P22626 | S189 | Sugiyama | HNRNPA2B1 HNRPA2B1 | IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF |
| P23588 | S597 | Sugiyama | EIF4B | KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______ |
| P25054 | S1279 | SIGNOR|ELM|iPTMNet|PSP | APC DP2.5 | IQTYCVEDTPICFSRCSSLSsLSSAEDEIGCNQTTQEADSA |
| P25054 | S1392 | SIGNOR|ELM|iPTMNet|PSP | APC DP2.5 | PPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEPCSG |
| P25054 | S1504 | iPTMNet | APC DP2.5 | DADTLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELRI |
| P25054 | S1505 | iPTMNet | APC DP2.5 | ADTLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELRIM |
| P25054 | S1507 | iPTMNet | APC DP2.5 | TLLHFATESTPDGFsCsssLsALsLDEPFIQKDVELRIMPP |
| P25054 | S1510 | iPTMNet | APC DP2.5 | HFATESTPDGFsCsssLsALsLDEPFIQKDVELRIMPPVQE |
| P25205 | Y19 | Sugiyama | MCM3 | __MAGtVVLDDVELREAQRDyLDFLDDEEDQGIyQsKVREL |
| P25705 | S53 | Sugiyama | ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM | ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR |
| P25788 | S243 | Sugiyama | PSMA3 HC8 PSC8 | GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________ |
| P25788 | S250 | Sugiyama | PSMA3 HC8 PSC8 | KDIREEAEKyAKEsLKEEDEsDDDNM_______________ |
| P27348 | T30 | Sugiyama | YWHAQ | AKLAEQAERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKN |
| P27797 | S189 | Sugiyama | CALR CRTC | THLytLIVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIK |
| P27797 | S195 | Sugiyama | CALR CRTC | IVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIKDPDAsK |
| P28066 | S174 | Sugiyama | PSMA5 | FHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEA |
| P28066 | S179 | Sugiyama | PSMA5 | sGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEAIKSSL |
| P28340 | S60 | Sugiyama | POLD1 POLD | LMEEMEAEHRLQEQEEEELQsVLEGVADGQVPPsAIDPRWL |
| P29401 | S295 | Sugiyama | TKT | ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI |
| P29401 | T454 | Sugiyama | TKT | LAMFRsVPtstVFyPsDGVAtEKAVELAANTKGICFIRTsR |
| P29692 | S162 | Sugiyama | EEF1D EF1D | AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY |
| P29692 | S44 | Sugiyama | EEF1D EF1D | RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs |
| P29692 | T147 | Sugiyama | EEF1D EF1D | PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE |
| P30043 | T199 | Sugiyama | BLVRB FLR SCAN | HDLGHFMLRCLttDEyDGHstyPsHQyQ_____________ |
| P30050 | S138 | Sugiyama | RPL12 | HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG |
| P31327 | S1090 | Sugiyama | CPS1 | KNGVKIMGTsPLQIDRAEDRsIFsAVLDELKVAQAPWKAVN |
| P31327 | S1093 | Sugiyama | CPS1 | VKIMGTsPLQIDRAEDRsIFsAVLDELKVAQAPWKAVNTLN |
| P34931 | S42 | Sugiyama | HSPA1L | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P34931 | T47 | Sugiyama | HSPA1L | KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN |
| P34932 | S414 | Sugiyama | HSPA4 APG2 HSPH2 | ITDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTF |
| P35222 | S45 | SIGNOR|PSP | CTNNB1 CTNNB OK/SW-cl.35 PRO2286 | WQQQsyLDsGIHsGATtTAPsLsGKGNPEEEDVDTsQVLyE |
| P35579 | S169 | Sugiyama | MYH9 | HIyAITDtAyRSMMQDREDQsILCTGESGAGKTENTKKVIQ |
| P35637 | S182 | PSP | FUS TLS | NssSGGGGGGGGGGNYGQDQssMSSGGGSGGGYGNQDQSGG |
| P36578 | S55 | Sugiyama | RPL4 RPL1 | DIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVAR |
| P36578 | S87 | Sugiyama | RPL4 RPL1 | WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT |
| P36578 | T62 | Sugiyama | RPL4 RPL1 | TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG |
| P36578 | T84 | Sugiyama | RPL4 RPL1 | AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP |
| P38646 | S89 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA |
| P38646 | T86 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK |
| P38646 | T94 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN |
| P39023 | S265 | Sugiyama | RPL3 OK/SW-cl.32 | HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY |
| P40227 | T147 | Sugiyama | CCT6A CCT6 CCTZ | KEKALQFLEEVKVSREMDREtLIDVARTSLRTKVHAELADV |
| P40925 | S326 | Sugiyama | MDH1 MDHA | NDFSREKMDLTAKELtEEKEsAFEFLssA____________ |
| P40925 | S333 | Sugiyama | MDH1 MDHA | MDLTAKELtEEKEsAFEFLssA___________________ |
| P43034 | S152 | Sugiyama | PAFAH1B1 LIS1 MDCR MDS PAFAHA | IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM |
| P46783 | S146 | Sugiyama | RPS10 | TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_ |
| P46783 | T148 | Sugiyama | RPS10 | RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___ |
| P46937 | S400 | SIGNOR | YAP1 YAP65 | NssDPFLNsGtyHsRDEstDsGLsMssysVPRtPDDFLNsV |
| P46937 | S403 | SIGNOR | YAP1 YAP65 | DPFLNsGtyHsRDEstDsGLsMssysVPRtPDDFLNsVDEM |
| P47712 | S454 | Sugiyama | PLA2G4A CPLA2 PLA2G4 | ssDsDDEsHEPKGtENEDAGsDyQsDNQASWIHRMIMALVS |
| P48730 | S181 | Sugiyama | CSNK1D HCKID | tHQHIPYRENKNLtGtARYAsINtHLGIEQsRRDDLESLGY |
| P48730 | T184 | Sugiyama | CSNK1D HCKID | HIPYRENKNLtGtARYAsINtHLGIEQsRRDDLESLGYVLM |
| P48741 | S42 | Sugiyama | HSPA7 HSP70B | VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA |
| P48741 | T47 | Sugiyama | HSPA7 HSP70B | RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN |
| P49321 | S210 | Sugiyama | NASP | KsAEEPQEKVDLtLDWLtEtsEEAKGGAAPEGPNEAEVtsG |
| P49321 | T207 | Sugiyama | NASP | DIsKsAEEPQEKVDLtLDWLtEtsEEAKGGAAPEGPNEAEV |
| P49327 | S2198 | Sugiyama | FASN FAS | EVRQLTLRKLQELSSKADEAsELACPtPKEDGLAQQQtQLN |
| P49588 | S188 | Sugiyama | AARS1 AARS | PGNMKDNFWEMGDtGPCGPCsEIHyDRIGGRDAAHLVNQDD |
| P49674 | S181 | Sugiyama | CSNK1E | THQHIPYRENKNLTGTARYAsINtHLGIEQSRRDDLESLGY |
| P49674 | S323 | SIGNOR|ELM|iPTMNet|PSP|Sugiyama | CSNK1E | DVDRERREHEREERMGQLRGsAtRALPPGPPtGAtANRLRs |
| P49674 | S368 | SIGNOR|ELM|iPTMNet|PSP | CSNK1E | VASTPAsRIQPAGNtsPRAIsRVDRERKVSMRLHRGAPANV |
| P49674 | S405 | SIGNOR|ELM|iPTMNet|PSP | CSNK1E | PANVsssDLTGRQEVSRIPAsQtsVPFDHLGK_________ |
| P49674 | S408 | SIGNOR|ELM|iPTMNet|PSP | CSNK1E | VsssDLTGRQEVSRIPAsQtsVPFDHLGK____________ |
| P49674 | T184 | Sugiyama | CSNK1E | HIPYRENKNLTGTARYAsINtHLGIEQSRRDDLESLGYVLM |
| P49674 | T325 | SIGNOR|ELM|iPTMNet|PSP|Sugiyama | CSNK1E | DRERREHEREERMGQLRGsAtRALPPGPPtGAtANRLRsAA |
| P49674 | T334 | SIGNOR|ELM|iPTMNet|PSP|Sugiyama | CSNK1E | EERMGQLRGsAtRALPPGPPtGAtANRLRsAAEPVASTPAs |
| P49674 | T337 | SIGNOR|ELM|iPTMNet|PSP|Sugiyama | CSNK1E | MGQLRGsAtRALPPGPPtGAtANRLRsAAEPVASTPAsRIQ |
| P49674 | T407 | SIGNOR|ELM|iPTMNet|PSP | CSNK1E | NVsssDLTGRQEVSRIPAsQtsVPFDHLGK___________ |
| P50454 | S139 | Sugiyama | SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 | SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS |
| P50454 | S141 | Sugiyama | SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14 | STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI |
| P51116 | S601 | Sugiyama | FXR2 FMR1L2 | RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ |
| P51532 | S699 | Sugiyama | SMARCA4 BAF190A BRG1 SNF2B SNF2L4 | PPTLPVEEKKKIPDPDsDDVsEVDARHIIENAKQDVDDEyG |
| P52597 | S107 | Sugiyama | HNRNPF HNRPF | KSHRTEMDWVLKHsGPNsADsANDGFVRLRGLPFGCTKEEI |
| P52597 | S63 | Sugiyama | HNRNPF HNRPF | VHFIYTREGRQsGEAFVELGsEDDVKMALKKDRESMGHRyI |
| P52948 | S625 | Sugiyama | NUP98 ADAR2 | LNNsNLFsPVNRDsENLAsPsEyPENGERFsFLSKPVDENH |
| P53999 | S118 | Sugiyama | SUB1 PC4 RPO2TC1 | PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________ |
| P53999 | S19 | Sugiyama | SUB1 PC4 RPO2TC1 | __MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPVKK |
| P54652 | S224 | Sugiyama | HSPA2 | GGGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHL |
| P54652 | S41 | Sugiyama | HSPA2 | VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA |
| P54652 | T46 | Sugiyama | HSPA2 | KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN |
| P55060 | S366 | Sugiyama | CSE1L CAS XPO2 | KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA |
| P55072 | S37 | Sugiyama | VCP HEL-220 HEL-S-70 | LKQKNRPNRLIVDEAINEDNsVVsLSQPKMDELQLFRGDTV |
| P55072 | S40 | Sugiyama | VCP HEL-220 HEL-S-70 | KNRPNRLIVDEAINEDNsVVsLSQPKMDELQLFRGDTVLLK |
| P55854 | S27 | Sugiyama | SUMO3 SMT3A SMT3H1 | KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC |
| P55957 | S64 | SIGNOR|iPTMNet | BID | LPVLAPQWEGyDELQtDGNRssHsRLGRIEADsEsQEDIIR |
| P55957 | T59 | SIGNOR|iPTMNet | BID | ALGHELPVLAPQWEGyDELQtDGNRssHsRLGRIEADsEsQ |
| P56645 | S622 | SIGNOR|iPTMNet | PER3 GIG13 | NGRSIDTGGGAPQILSTAMLsLGsGIsQCGYsstIVHVPPP |
| P56645 | S625 | SIGNOR|iPTMNet | PER3 GIG13 | SIDTGGGAPQILSTAMLsLGsGIsQCGYsstIVHVPPPETA |
| P56645 | S628 | SIGNOR|iPTMNet | PER3 GIG13 | TGGGAPQILSTAMLsLGsGIsQCGYsstIVHVPPPETARDA |
| P56645 | S633 | SIGNOR|iPTMNet | PER3 GIG13 | PQILSTAMLsLGsGIsQCGYsstIVHVPPPETARDATLFCE |
| P56645 | S634 | SIGNOR|iPTMNet | PER3 GIG13 | QILSTAMLsLGsGIsQCGYsstIVHVPPPETARDATLFCEP |
| P56645 | T635 | SIGNOR|iPTMNet | PER3 GIG13 | ILSTAMLsLGsGIsQCGYsstIVHVPPPETARDATLFCEPW |
| P60174 | S212 | Sugiyama | TPI1 TPI | WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV |
| P60174 | T217 | Sugiyama | TPI1 TPI | VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL |
| P60660 | S30 | Sugiyama | MYL6 | AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK |
| P60709 | S368 | Sugiyama | ACTB | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P60709 | S52 | Sugiyama | ACTB | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P60709 | S60 | Sugiyama | ACTB | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P60709 | Y53 | Sugiyama | ACTB | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P61247 | S236 | Sugiyama | RPS3A FTE1 MFTL | KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy |
| P61916 | S29 | Sugiyama | NPC2 HE1 | LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL |
| P61956 | S28 | Sugiyama | SUMO2 SMT3B SMT3H2 | EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC |
| P61981 | T31 | Sugiyama | YWHAG | ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN |
| P62258 | S148 | Sugiyama | YWHAE | YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP |
| P62258 | S156 | Sugiyama | YWHAE | AtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLGLALN |
| P62273 | Y7 | Sugiyama | RPS29 | ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR |
| P62736 | S54 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P62736 | S62 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P62736 | Y55 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P62857 | S61 | Sugiyama | RPS28 | sIIRNVKGPVREGDVLtLLEsEREARRLR____________ |
| P62857 | T57 | Sugiyama | RPS28 | DtsRsIIRNVKGPVREGDVLtLLEsEREARRLR________ |
| P63104 | S28 | Sugiyama | YWHAZ | QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy |
| P63104 | T30 | Sugiyama | YWHAZ | AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN |
| P63167 | T26 | Sugiyama | DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 | AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF |
| P63261 | S368 | Sugiyama | ACTG1 ACTG | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P63261 | S52 | Sugiyama | ACTG1 ACTG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P63261 | S60 | Sugiyama | ACTG1 ACTG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P63261 | Y53 | Sugiyama | ACTG1 ACTG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P63267 | S53 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P63267 | S61 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P63267 | Y54 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68032 | S54 | Sugiyama | ACTC1 ACTC | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68032 | S62 | Sugiyama | ACTC1 ACTC | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68032 | Y55 | Sugiyama | ACTC1 ACTC | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68133 | S54 | Sugiyama | ACTA1 ACTA | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68133 | S62 | Sugiyama | ACTA1 ACTA | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68133 | Y55 | Sugiyama | ACTA1 ACTA | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68363 | S439 | Sugiyama | TUBA1B | SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________ |
| P68363 | S48 | Sugiyama | TUBA1B | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P68363 | S54 | Sugiyama | TUBA1B | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| P68363 | T51 | Sugiyama | TUBA1B | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| P68363 | T73 | Sugiyama | TUBA1B | FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI |
| P68363 | T80 | Sugiyama | TUBA1B | KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA |
| P68363 | Y83 | Sugiyama | TUBA1B | PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy |
| P78371 | S101 | Sugiyama | CCT2 99D8.1 CCTB | AKVLVDMSRVQDDEVGDGTTsVtVLAAELLREAESLIAKKI |
| P78371 | T103 | Sugiyama | CCT2 99D8.1 CCTB | VLVDMSRVQDDEVGDGTTsVtVLAAELLREAESLIAKKIHP |
| Q04917 | T31 | Sugiyama | YWHAH YWHA1 | ARLAEQAERyDDMAsAMKAVtELNEPLsNEDRNLLsVAyKN |
| Q07021 | S201 | Sugiyama | C1QBP GC1QBP HABP1 SF2P32 | ALVLDCHyPEDEVGQEDEAEsDIFsIREVsFQstGESEWKD |
| Q07021 | S205 | Sugiyama | C1QBP GC1QBP HABP1 SF2P32 | DCHyPEDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYT |
| Q07960 | S47 | Sugiyama | ARHGAP1 CDC42GAP RHOGAP1 | SIDEKNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDI |
| Q07960 | S49 | Sugiyama | ARHGAP1 CDC42GAP RHOGAP1 | DEKNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIAR |
| Q07960 | S50 | Sugiyama | ARHGAP1 CDC42GAP RHOGAP1 | EKNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARH |
| Q08J23 | S724 | Sugiyama | NSUN2 SAKI TRM4 | LEVLGEKKKEGVILtNEsAAstGQPDNDVtEGQRAGEPNsP |
| Q12792 | T164 | Sugiyama | TWF1 PTK9 | PAPLtAAEEELRQIKINEVQtDVGVDTKHQtLQGVAFPISR |
| Q13114 | S349 | SIGNOR|PSP | TRAF3 CAP-1 CRAF1 TRAFAMN | KLKELDKEIRPFRQNWEEADsMKSSVESLQNRVTELESVDK |
| Q13114 | Y116 | SIGNOR|PSP | TRAF3 CAP-1 CRAF1 TRAFAMN | VKDKVFKDNCCKREILALQIyCRNESRGCAEQLMLGHLLVH |
| Q13114 | Y446 | SIGNOR|PSP | TRAF3 CAP-1 CRAF1 TRAFAMN | KRRKQEAVMGKTLSLYSQPFyTGYFGYKMCARVYLNGDGMG |
| Q13148 | S379 | PSP | TARDBP TDP43 | MQREPNQAFGsGNNSYsGsNsGAAIGWGsAsNAGsGsGFNG |
| Q13148 | S403 | PSP | TARDBP TDP43 | IGWGsAsNAGsGsGFNGGFGssMDsKssGWGM_________ |
| Q13148 | S404 | PSP | TARDBP TDP43 | GWGsAsNAGsGsGFNGGFGssMDsKssGWGM__________ |
| Q13148 | S409 | PSP | TARDBP TDP43 | sNAGsGsGFNGGFGssMDsKssGWGM_______________ |
| Q13148 | S410 | PSP | TARDBP TDP43 | NAGsGsGFNGGFGssMDsKssGWGM________________ |
| Q13263 | S784 | Sugiyama | TRIM28 KAP1 RNF96 TIF1B | DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK |
| Q13283 | T241 | Sugiyama | G3BP1 G3BP | ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP |
| Q13428 | S85 | Sugiyama | TCOF1 | AEEDAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRL |
| Q13428 | T84 | Sugiyama | TCOF1 | KAEEDAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPR |
| Q13541 | S112 | Sugiyama | EIF4EBP1 | EAsQsHLRNsPEDKRAGGEEsQFEMDI______________ |
| Q13541 | T41 | SIGNOR|PSP | EIF4EBP1 | VVLGDGVQLPPGDysttPGGtLFsttPGGtRIIyDRKFLME |
| Q13541 | T50 | SIGNOR|PSP | EIF4EBP1 | PPGDysttPGGtLFsttPGGtRIIyDRKFLMECRNsPVtKt |
| Q14152 | T1378 | Sugiyama | EIF3A EIF3S10 KIAA0139 | AEKDREsLRRTKNEtDEDGWttVRR________________ |
| Q14152 | T1379 | Sugiyama | EIF3A EIF3S10 KIAA0139 | EKDREsLRRTKNEtDEDGWttVRR_________________ |
| Q14203 | S417 | Sugiyama | DCTN1 | KKNQELEVVRQQRERLQEELsQAEstIDELKEQVDAALGAE |
| Q14203 | S421 | Sugiyama | DCTN1 | ELEVVRQQRERLQEELsQAEstIDELKEQVDAALGAEEMVE |
| Q14203 | T422 | Sugiyama | DCTN1 | LEVVRQQRERLQEELsQAEstIDELKEQVDAALGAEEMVEM |
| Q14257 | S146 | Sugiyama | RCN2 ERC55 | MyDRVIDFDENtALDDAEEEsFRKLHLKDKKRFEKANQDSG |
| Q14257 | T137 | Sugiyama | RCN2 ERC55 | VTWDEyNIQMyDRVIDFDENtALDDAEEEsFRKLHLKDKKR |
| Q14257 | Y311 | Sugiyama | RCN2 ERC55 | NPDLFLtsEAtDyGRQLHDDyFyHDEL______________ |
| Q14444 | S97 | Sugiyama | CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 | DYQERMNKGERLNQDQLDAVsKyQEVtNNLEFAKELQRsFM |
| Q14498 | S334 | Sugiyama | RBM39 HCC1 RNPC2 | FELAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtT |
| Q14498 | S336 | Sugiyama | RBM39 HCC1 RNPC2 | LAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGR |
| Q14498 | S337 | Sugiyama | RBM39 HCC1 RNPC2 | AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL |
| Q14677 | S210 | Sugiyama | CLINT1 ENTH EPN4 EPNR KIAA0171 | KNKSAFPFSDKLGELsDKIGstIDDtIsKFRRKDREDsPER |
| Q14694 | S576 | Sugiyama | USP10 KIAA0190 | sNGPKNHSVNEEEQEEQGEGsEDEWEQVGPRNKTSVTRQAD |
| Q15084 | S428 | Sugiyama | PDIA6 ERP5 P5 TXNDC7 | EREPWDGRDGELPVEDDIDLsDVELDDLGKDEL________ |
| Q15181 | S127 | Sugiyama | PPA1 IOPPP PP | NDKHTGCCGDNDPIDVCEIGsKVCARGEIIGVKVLGILAMI |
| Q15185 | S72 | Sugiyama | PTGES3 P23 TEBP | EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE |
| Q15293 | T71 | Sugiyama | RCN1 RCN | EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI |
| Q15758 | S535 | Sugiyama | SLC1A5 ASCT2 M7V1 RDR RDRC | EEGNPLLKHyRGPAGDAtVAsEKEsVM______________ |
| Q15758 | S539 | Sugiyama | SLC1A5 ASCT2 M7V1 RDR RDRC | PLLKHyRGPAGDAtVAsEKEsVM__________________ |
| Q15758 | T532 | Sugiyama | SLC1A5 ASCT2 M7V1 RDR RDRC | VPTEEGNPLLKHyRGPAGDAtVAsEKEsVM___________ |
| Q16513 | S583 | Sugiyama | PKN2 PRK2 PRKCL2 | VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs |
| Q16637 | S28 | Sugiyama | SMN1 SMN SMNT; SMN2 SMNC | sGGGVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVA |
| Q16637 | S31 | Sugiyama | SMN1 SMN SMNT; SMN2 SMNC | GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK |
| Q16658 | S489 | Sugiyama | FSCN1 FAN1 HSN SNL | YLKGDHAGVLKASAEtVDPAsLWEy________________ |
| Q16658 | T484 | Sugiyama | FSCN1 FAN1 HSN SNL | KVGGRYLKGDHAGVLKASAEtVDPAsLWEy___________ |
| Q2TAA2 | S241 | Sugiyama | IAH1 | SSLPLLLPYWRDVAEAKPELsLLGDGDH_____________ |
| Q58FF6 | T165 | Sugiyama | HSP90AB4P | DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG |
| Q58FF7 | S370 | Sugiyama | HSP90AB3P HSP90BC | KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI |
| Q58FF7 | T169 | Sugiyama | HSP90AB3P HSP90BC | DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG |
| Q5H9R7 | S617 | Sugiyama | PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 | NIALFEACCKERIQQFDDGGsDEEDIWEEKHIAFtPEsQRR |
| Q5SSJ5 | S441 | Sugiyama | HP1BP3 | VLFPKKEPDDSRDEDEDEDEssEEDsEDEEPPPKRRLQKKT |
| Q5SSJ5 | S446 | Sugiyama | HP1BP3 | KEPDDSRDEDEDEDEssEEDsEDEEPPPKRRLQKKTPAKSP |
| Q6EEV6 | S28 | Sugiyama | SUMO4 SMT3H4 | EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC |
| Q6P996 | S718 | Sugiyama | PDXDC1 KIAA0251 | KQRLPGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssG |
| Q6P996 | S721 | Sugiyama | PDXDC1 KIAA0251 | LPGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQ |
| Q6P996 | S722 | Sugiyama | PDXDC1 KIAA0251 | PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI |
| Q6P996 | T720 | Sugiyama | PDXDC1 KIAA0251 | RLPGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPE |
| Q6PEY2 | S48 | Sugiyama | TUBA3E | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q6PEY2 | S54 | Sugiyama | TUBA3E | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| Q6PEY2 | T51 | Sugiyama | TUBA3E | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q6S8J3 | S1068 | Sugiyama | POTEE A26C1A POTE2 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q6ULP2 | S508 | Sugiyama | AFTPH AFTH | SCQEETILTKSDLKQTSDNLsEECQLARKSSGTGTEPVAKL |
| Q6UN15 | S87 | Sugiyama | FIP1L1 FIP1 RHE | EtAENGVPKPKVTETEDDsDsDsDDDEDDVHVTIGDIKTGA |
| Q6UXH1 | S295 | Sugiyama | CRELD2 UNQ185/PRO211 | KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY |
| Q71U36 | S439 | Sugiyama | TUBA1A TUBA3 | SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________ |
| Q71U36 | S48 | Sugiyama | TUBA1A TUBA3 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q71U36 | S54 | Sugiyama | TUBA1A TUBA3 | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| Q71U36 | T51 | Sugiyama | TUBA1A TUBA3 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q71U36 | T73 | Sugiyama | TUBA1A TUBA3 | FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI |
| Q71U36 | T80 | Sugiyama | TUBA1A TUBA3 | KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA |
| Q71U36 | Y83 | Sugiyama | TUBA1A TUBA3 | PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy |
| Q86SQ0 | S493 | Sugiyama | PHLDB2 LL5B | VEDVQKINKELEKLQLsDEEsVFEEALMsPDTRYRCHRKDs |
| Q8NBJ7 | S283 | Sugiyama | SUMF2 PSEC0171 UNQ1968/PRO4500 | GsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPPGEL__ |
| Q8ND56 | S374 | Sugiyama | LSM14A C19orf13 FAM61A RAP55 RAP55A | EDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEERRLNAE |
| Q8NE71 | S595 | Sugiyama | ABCF1 ABC50 | TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP |
| Q8NHW5 | S304 | Sugiyama | RPLP0P6 | DTTAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______ |
| Q8NHW5 | S307 | Sugiyama | RPLP0P6 | AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________ |
| Q8TD43 | S839 | PSP | TRPM4 LTRPC4 | FWAFTLLCEELRQGLSGGGGsLASGGPGPGHASLSQRLRLY |
| Q8WU90 | S231 | Sugiyama | ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 | LPPGFVLKKDKKKEEKEDEIsLEDLIERERSALGPNVTKIT |
| Q8WWM7 | S275 | Sugiyama | ATXN2L A2D A2LG A2LP A2RP | EMFKFNEENyGVKTtyDssLssytVPLEKDNsEEFRQRELR |
| Q8WWM7 | T278 | Sugiyama | ATXN2L A2D A2LG A2LP A2RP | KFNEENyGVKTtyDssLssytVPLEKDNsEEFRQRELRAAQ |
| Q8WWM7 | Y277 | Sugiyama | ATXN2L A2D A2LG A2LP A2RP | FKFNEENyGVKTtyDssLssytVPLEKDNsEEFRQRELRAA |
| Q92769 | S422 | Sugiyama | HDAC2 | PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA |
| Q92973 | T335 | Sugiyama | TNPO1 KPNB2 MIP1 TRN | GMKySDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQ |
| Q92997 | S280 | SIGNOR|PSP | DVL3 KIAA0208 | LGIsIVGQSNERGDGGIYIGsIMKGGAVAADGRIEPGDMLL |
| Q92997 | S311 | SIGNOR|PSP | DVL3 KIAA0208 | GRIEPGDMLLQVNEINFENMsNDDAVRVLREIVHKPGPITL |
| Q92997 | S611 | PSP | DVL3 KIAA0208 | PKAGDSKSGGsGsEsDHTTRssLRGPRERAPsERsGPAASE |
| Q92997 | S612 | PSP | DVL3 KIAA0208 | KAGDSKSGGsGsEsDHTTRssLRGPRERAPsERsGPAASEH |
| Q92997 | S633 | PSP | DVL3 KIAA0208 | LRGPRERAPsERsGPAASEHsHRsHHsLAssLRSHHTHPSY |
| Q92997 | S636 | PSP | DVL3 KIAA0208 | PRERAPsERsGPAASEHsHRsHHsLAssLRSHHTHPSYGPP |
| Q92997 | S639 | PSP | DVL3 KIAA0208 | RAPsERsGPAASEHsHRsHHsLAssLRSHHTHPSYGPPGVP |
| Q92997 | S642 | PSP | DVL3 KIAA0208 | sERsGPAASEHsHRsHHsLAssLRSHHTHPSYGPPGVPPLY |
| Q92997 | S643 | PSP | DVL3 KIAA0208 | ERsGPAASEHsHRsHHsLAssLRSHHTHPSYGPPGVPPLYG |
| Q96ER3 | T63 | Sugiyama | SAAL1 | LIQIVSPENTKsssDDEEQLtELDEEMENEICRVWDMSMDE |
| Q96G46 | T57 | Sugiyama | DUS3L | TKEQFHQFLEAKGQEKtCREtEVGDPAGNELAEPEAKRIRL |
| Q96HE7 | S143 | Sugiyama | ERO1A ERO1L UNQ434/PRO865 | EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD |
| Q96S66 | S59 | Sugiyama | CLCC1 KIAA0761 MCLC | MRKSQAKYGISGEKDVSPDLsCADEIsECyHKLDSLTYKID |
| Q96S66 | S65 | Sugiyama | CLCC1 KIAA0761 MCLC | KYGISGEKDVSPDLsCADEIsECyHKLDSLTYKIDECEKKK |
| Q96SB4 | S334 | Sugiyama | SRPK1 | ERPLKENPPNKMtQEKLEEsstIGQDQtLMERDTEGGAAEI |
| Q96SB4 | T335 | Sugiyama | SRPK1 | RPLKENPPNKMtQEKLEEsstIGQDQtLMERDTEGGAAEIN |
| Q99961 | S108 | Sugiyama | SH3GL1 CNSA1 SH3D2B | QSEGLLGECMIRHGKELGGEsNFGDALLDAGEsMKRLAEVK |
| Q9BQ52 | S215 | Sugiyama | ELAC2 HPC2 | QPWQsPERPLsRLsPERssDsEsNENEPHLPHGVsQRRGVR |
| Q9BQ52 | S217 | Sugiyama | ELAC2 HPC2 | WQsPERPLsRLsPERssDsEsNENEPHLPHGVsQRRGVRDs |
| Q9BQE3 | S48 | Sugiyama | TUBA1C TUBA6 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q9BQE3 | S54 | Sugiyama | TUBA1C TUBA6 | GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV |
| Q9BQE3 | T51 | Sugiyama | TUBA1C TUBA6 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q9BQE3 | T73 | Sugiyama | TUBA1C TUBA6 | FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI |
| Q9BQE3 | T80 | Sugiyama | TUBA1C TUBA6 | KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA |
| Q9BQE3 | Y83 | Sugiyama | TUBA1C TUBA6 | PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy |
| Q9BRS2 | S21 | Sugiyama | RIOK1 RIO1 | MDYRRLLMSRVVPGQFDDADssDsENRDLKTVKEKDDILFE |
| Q9BRS2 | S24 | Sugiyama | RIOK1 RIO1 | RRLLMSRVVPGQFDDADssDsENRDLKTVKEKDDILFEDLQ |
| Q9BVS4 | S332 | Sugiyama | RIOK2 RIO2 | DDELLHPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsEN |
| Q9BVS4 | S335 | Sugiyama | RIOK2 RIO2 | LLHPLGPDDKNIETKEGsEFsFsDGEVAEKAEVyGsENEsE |
| Q9BYX7 | S368 | Sugiyama | POTEKP ACTBL3 FKSG30 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q9BZL6 | S244 | PSP | PRKD2 PKD2 HSPC187 | RsttELLPRRPPsssssssAssYTGRPIELDKMLLSKVKVP |
| Q9C0C2 | S1174 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | ttAGsVDWTDQLGLRNLEVssCVGsGGssEAREsAVGQMGW |
| Q9GZV5 | S314 | SIGNOR | WWTR1 TAZ | NssDPFLNGGPyHsREQsTDsGLGLGCySVPTtPEDFLSNV |
| Q9H1E3 | S144 | Sugiyama | NUCKS1 NUCKS JC7 | PFQEKDsGsDEDFLMEDDDDsDyGSsKKKNKKMVKKSKPER |
| Q9H2G2 | S571 | Sugiyama | SLK KIAA0204 STK2 | tCEAADVAQKVDEDsAEDtQsNDGKEVVEVGQKLINKPMVG |
| Q9H2U2 | S309 | Sugiyama | PPA2 HSPC124 | NCTNVQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVW |
| Q9H2U2 | S313 | Sugiyama | PPA2 HSPC124 | VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG |
| Q9H3P7 | S393 | Sugiyama | ACBD3 GCP60 GOCAP1 GOLPH1 | SMWTRPQIKDFKEKIQQDADsVItVGRGEVVTVRVPTHEEG |
| Q9H3P7 | T396 | Sugiyama | ACBD3 GCP60 GOCAP1 GOLPH1 | TRPQIKDFKEKIQQDADsVItVGRGEVVTVRVPTHEEGSYL |
| Q9HCN4 | S338 | Sugiyama | GPN1 MBDIN RPAP4 XAB1 HUSSY-23 | HPsDLILtRGTLDEEDEEADsDtDDIDHRVTEESHEEPAFQ |
| Q9NQ39 | S157 | Sugiyama | RPS10P5 RPS10L | TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_ |
| Q9NQ39 | T159 | Sugiyama | RPS10P5 RPS10L | RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___ |
| Q9NR28 | S230 | Sugiyama | DIABLO SMAC | EAQIEELRQKTQEEGEERAEsEQEAyLRED___________ |
| Q9NRF8 | S571 | Sugiyama | CTPS2 | LNAYLQQGCKLsssDRysDAsDDsFSEPRIAELEIS_____ |
| Q9NRF8 | Y567 | Sugiyama | CTPS2 | ATGNLNAYLQQGCKLsssDRysDAsDDsFSEPRIAELEIS_ |
| Q9NTJ3 | S504 | Sugiyama | SMC4 CAPC SMC4L1 | ELMGFSKSVNEARSKMDVAQsELDIyLSRHNTAVSQLTKAK |
| Q9NUQ3 | S86 | Sugiyama | TXLNG CXorf15 ELRG LSR5 | HQGSNCGGTSNKHSLEEDEGsDFItENRNLVsPAyCtQEsR |
| Q9P2I0 | S423 | Sugiyama | CPSF2 CPSF100 KIAA1367 | KEAAKKLEQSKEADIDssDEsDIEEDIDQPSAHKTKHDLMM |
| Q9UBQ5 | S209 | Sugiyama | EIF3K EIF3S12 ARG134 HSPC029 MSTP001 PTD001 | ICSQEESIKPKNIVEKIDFDsVSsIMAssQ___________ |
| Q9UBQ5 | S212 | Sugiyama | EIF3K EIF3S12 ARG134 HSPC029 MSTP001 PTD001 | QEESIKPKNIVEKIDFDsVSsIMAssQ______________ |
| Q9UHD8 | S247 | Sugiyama | SEPTIN9 KIAA0991 MSF SEPT9 | PQPPVAEAtPRsQEATEAAPsCVGDMADtPRDAGLKQAPAS |
| Q9UPT8 | S137 | Sugiyama | ZC3H4 C19orf7 KIAA1064 | RSKKRRKSKHKRHAsSSDDFsDFsDDsDFsPSEKGHRKyRE |
| Q9UPT8 | S140 | Sugiyama | ZC3H4 C19orf7 KIAA1064 | KRRKSKHKRHAsSSDDFsDFsDDsDFsPSEKGHRKyREysP |
| Q9UPT8 | S143 | Sugiyama | ZC3H4 C19orf7 KIAA1064 | KSKHKRHAsSSDDFsDFsDDsDFsPSEKGHRKyREysPPyA |
| Q9Y266 | S281 | Sugiyama | NUDC | DPEINtKKINPENsKLsDLDsEtRsMVEKMMYDQRQKsMGL |
| Q9Y266 | S285 | Sugiyama | NUDC | NtKKINPENsKLsDLDsEtRsMVEKMMYDQRQKsMGLPtsD |
| Q9Y266 | T145 | Sugiyama | NUDC | AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN |
| Q9Y2B0 | S65 | Sugiyama | CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 | VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI |
| Q9Y5S9 | S56 | Sugiyama | RBM8A RBM8 HSPC114 MDS014 | KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF |
| Q9Y696 | S245 | Sugiyama | CLIC4 | ysRDEFtNtCPsDKEVEIAysDVAKRLTK____________ |
| Q9Y6Q9 | S102 | PSP | NCOA3 AIB1 BHLHE42 RAC3 TRAM1 | IKEQGKTISNDDDVQKADVssTGQGVIDKDSLGPLLLQALD |
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Nuclear Envelope Breakdown | R-HSA-2980766 | 5.925394e-08 | 7.227 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 1.156204e-06 | 5.937 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 3.829359e-06 | 5.417 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 7.447760e-06 | 5.128 | 1 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 1.106779e-05 | 4.956 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 1.280135e-05 | 4.893 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 1.416676e-05 | 4.849 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 2.791897e-05 | 4.554 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 3.177505e-05 | 4.498 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 3.342562e-05 | 4.476 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 4.309781e-05 | 4.366 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 5.608266e-05 | 4.251 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 5.512115e-05 | 4.259 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 5.608266e-05 | 4.251 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 6.615866e-05 | 4.179 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 6.696532e-05 | 4.174 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 7.971615e-05 | 4.098 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 8.531485e-05 | 4.069 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 8.531485e-05 | 4.069 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 7.415266e-05 | 4.130 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 1.189320e-04 | 3.925 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 1.189320e-04 | 3.925 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 1.382715e-04 | 3.859 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 1.370489e-04 | 3.863 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 1.586034e-04 | 3.800 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 1.692410e-04 | 3.771 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 1.739338e-04 | 3.760 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 2.713003e-04 | 3.567 | 0 | 0 |
| M Phase | R-HSA-68886 | 3.168160e-04 | 3.499 | 1 | 0 |
| Negative regulation of activity of TFAP2 (AP-2) family transcription factors | R-HSA-8866904 | 3.651025e-04 | 3.438 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 4.496414e-04 | 3.347 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 5.504396e-04 | 3.259 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 5.913209e-04 | 3.228 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 6.332060e-04 | 3.198 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 7.413166e-04 | 3.130 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 7.494962e-04 | 3.125 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 7.696767e-04 | 3.114 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 8.569620e-04 | 3.067 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 8.681494e-04 | 3.061 | 1 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 9.599050e-04 | 3.018 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 1.206492e-03 | 2.918 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 1.164540e-03 | 2.934 | 1 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 1.224281e-03 | 2.912 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 1.232893e-03 | 2.909 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 1.121597e-03 | 2.950 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 1.182600e-03 | 2.927 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 1.283816e-03 | 2.891 | 1 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 1.309365e-03 | 2.883 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 1.375101e-03 | 2.862 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 1.382643e-03 | 2.859 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 1.556141e-03 | 2.808 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 1.638779e-03 | 2.785 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 1.638779e-03 | 2.785 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 1.576471e-03 | 2.802 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 1.585913e-03 | 2.800 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 1.771310e-03 | 2.752 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 1.779110e-03 | 2.750 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 1.893068e-03 | 2.723 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 2.120570e-03 | 2.674 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 2.336149e-03 | 2.631 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 2.467404e-03 | 2.608 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 2.788719e-03 | 2.555 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 2.788719e-03 | 2.555 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 2.707624e-03 | 2.567 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 2.695322e-03 | 2.569 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 2.789185e-03 | 2.555 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 3.147324e-03 | 2.502 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 3.519206e-03 | 2.454 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 3.484020e-03 | 2.458 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 3.564563e-03 | 2.448 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 3.905957e-03 | 2.408 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 4.939923e-03 | 2.306 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 4.974024e-03 | 2.303 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 5.579959e-03 | 2.253 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 6.025749e-03 | 2.220 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 6.025749e-03 | 2.220 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 6.696536e-03 | 2.174 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 8.095235e-03 | 2.092 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 8.175146e-03 | 2.088 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 8.201507e-03 | 2.086 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 8.345025e-03 | 2.079 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 9.056559e-03 | 2.043 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 9.146497e-03 | 2.039 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 9.162029e-03 | 2.038 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 9.802476e-03 | 2.009 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 1.021022e-02 | 1.991 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 1.070437e-02 | 1.970 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 1.147897e-02 | 1.940 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 1.161751e-02 | 1.935 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 1.161751e-02 | 1.935 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 1.219241e-02 | 1.914 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 1.230977e-02 | 1.910 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 1.230977e-02 | 1.910 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 1.230977e-02 | 1.910 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 1.230977e-02 | 1.910 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 1.230977e-02 | 1.910 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 1.332158e-02 | 1.875 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 1.295587e-02 | 1.888 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 1.326083e-02 | 1.877 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 1.333347e-02 | 1.875 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 1.402065e-02 | 1.853 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of cell cycle factors | R-HSA-8866911 | 1.417198e-02 | 1.849 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 1.450921e-02 | 1.838 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 1.537139e-02 | 1.813 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 1.540941e-02 | 1.812 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 1.604775e-02 | 1.795 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 1.764039e-02 | 1.753 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 1.764039e-02 | 1.753 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 1.666394e-02 | 1.778 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 1.639015e-02 | 1.785 | 0 | 0 |
| NFE2L2 regulating MDR associated enzymes | R-HSA-9818032 | 1.862841e-02 | 1.730 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 1.862841e-02 | 1.730 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 2.014017e-02 | 1.696 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 1.923728e-02 | 1.716 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 2.004710e-02 | 1.698 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 2.086445e-02 | 1.681 | 1 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 2.058128e-02 | 1.687 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 2.076668e-02 | 1.683 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 2.049202e-02 | 1.688 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 1.923728e-02 | 1.716 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 2.077040e-02 | 1.683 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 2.226293e-02 | 1.652 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 2.365120e-02 | 1.626 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 2.407519e-02 | 1.618 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 2.623504e-02 | 1.581 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 2.734363e-02 | 1.563 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 2.734363e-02 | 1.563 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 2.745724e-02 | 1.561 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 3.020371e-02 | 1.520 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 3.023135e-02 | 1.520 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 3.100740e-02 | 1.509 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 3.243442e-02 | 1.489 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 3.219372e-02 | 1.492 | 1 | 1 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 3.334029e-02 | 1.477 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 3.385383e-02 | 1.470 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 3.226304e-02 | 1.491 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 3.469013e-02 | 1.460 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 3.522404e-02 | 1.453 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 3.578513e-02 | 1.446 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 3.759524e-02 | 1.425 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 3.781772e-02 | 1.422 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 3.928339e-02 | 1.406 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 4.419550e-02 | 1.355 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 4.419550e-02 | 1.355 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 4.419550e-02 | 1.355 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 4.419550e-02 | 1.355 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 4.419550e-02 | 1.355 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 4.419550e-02 | 1.355 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 4.419550e-02 | 1.355 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 4.419550e-02 | 1.355 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 4.419550e-02 | 1.355 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 4.419550e-02 | 1.355 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 4.419550e-02 | 1.355 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 3.994725e-02 | 1.399 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 3.994725e-02 | 1.399 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 4.101135e-02 | 1.387 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 4.056679e-02 | 1.392 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 4.419550e-02 | 1.355 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 4.111278e-02 | 1.386 | 1 | 0 |
| Regulation of NFE2L2 gene expression | R-HSA-9818749 | 3.994725e-02 | 1.399 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 4.398719e-02 | 1.357 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 4.217641e-02 | 1.375 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 4.495860e-02 | 1.347 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 4.495860e-02 | 1.347 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 4.569582e-02 | 1.340 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 4.603567e-02 | 1.337 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 5.163369e-02 | 1.287 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 4.645992e-02 | 1.333 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 5.284418e-02 | 1.277 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 5.159386e-02 | 1.287 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 5.132156e-02 | 1.290 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 4.756206e-02 | 1.323 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 4.669539e-02 | 1.331 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 4.669539e-02 | 1.331 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | R-HSA-2892245 | 5.163369e-02 | 1.287 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 4.645992e-02 | 1.333 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 5.181765e-02 | 1.286 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 5.465015e-02 | 1.262 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 5.929555e-02 | 1.227 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 5.929555e-02 | 1.227 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 5.995908e-02 | 1.222 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 6.365597e-02 | 1.196 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 6.457080e-02 | 1.190 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 6.457080e-02 | 1.190 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 6.457080e-02 | 1.190 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 6.477548e-02 | 1.189 | 0 | 0 |
| Signaling by FGFR1 amplification mutants | R-HSA-1839120 | 6.546184e-02 | 1.184 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 6.546184e-02 | 1.184 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 6.546184e-02 | 1.184 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of other transcription factors | R-HSA-8866906 | 6.546184e-02 | 1.184 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 6.546184e-02 | 1.184 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 6.655178e-02 | 1.177 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 6.655178e-02 | 1.177 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 7.411251e-02 | 1.130 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 6.606145e-02 | 1.180 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 7.151010e-02 | 1.146 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 7.654980e-02 | 1.116 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 7.151888e-02 | 1.146 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 6.730701e-02 | 1.172 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 6.614662e-02 | 1.179 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 7.061438e-02 | 1.151 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 7.398114e-02 | 1.131 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 6.930914e-02 | 1.159 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 7.531543e-02 | 1.123 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 7.411251e-02 | 1.130 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 7.014223e-02 | 1.154 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 7.531543e-02 | 1.123 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 7.588943e-02 | 1.120 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 7.861892e-02 | 1.104 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 7.928718e-02 | 1.101 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 7.928718e-02 | 1.101 | 0 | 0 |
| Deletions in the AMER1 gene destabilize the destruction complex | R-HSA-5467343 | 7.956269e-02 | 1.099 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 7.956269e-02 | 1.099 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 7.984345e-02 | 1.098 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 8.038378e-02 | 1.095 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 8.214193e-02 | 1.085 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 8.378210e-02 | 1.077 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 8.428168e-02 | 1.074 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 8.608758e-02 | 1.065 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 8.707554e-02 | 1.060 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 8.707554e-02 | 1.060 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 8.939512e-02 | 1.049 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 8.939512e-02 | 1.049 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 8.939512e-02 | 1.049 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 8.939512e-02 | 1.049 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 8.939512e-02 | 1.049 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 9.056418e-02 | 1.043 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 9.152532e-02 | 1.038 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 9.152532e-02 | 1.038 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 9.187240e-02 | 1.037 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 9.200104e-02 | 1.036 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 9.507026e-02 | 1.022 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 9.507026e-02 | 1.022 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 9.928804e-02 | 1.003 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 1.069200e-01 | 0.971 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 1.059428e-01 | 0.975 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 1.107434e-01 | 0.956 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 1.069200e-01 | 0.971 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 1.069200e-01 | 0.971 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 1.098872e-01 | 0.959 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 9.928804e-02 | 1.003 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 1.082257e-01 | 0.966 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 9.303710e-02 | 1.031 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 1.093922e-01 | 0.961 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 1.001477e-01 | 0.999 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 1.082257e-01 | 0.966 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 9.542457e-02 | 1.020 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 1.120171e-01 | 0.951 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 1.120171e-01 | 0.951 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 1.120171e-01 | 0.951 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 1.120171e-01 | 0.951 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 1.139590e-01 | 0.943 | 0 | 0 |
| Defective DNA double strand break response due to BARD1 loss of function | R-HSA-9699150 | 1.527995e-01 | 0.816 | 0 | 0 |
| Defective DNA double strand break response due to BRCA1 loss of function | R-HSA-9663199 | 1.527995e-01 | 0.816 | 0 | 0 |
| Signaling by TCF7L2 mutants | R-HSA-5339700 | 2.202131e-01 | 0.657 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 2.202131e-01 | 0.657 | 0 | 0 |
| IRS activation | R-HSA-74713 | 1.154370e-01 | 0.938 | 0 | 0 |
| NFE2L2 regulating inflammation associated genes | R-HSA-9818026 | 1.154370e-01 | 0.938 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 1.154370e-01 | 0.938 | 0 | 0 |
| G2 Phase | R-HSA-68911 | 1.154370e-01 | 0.938 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 1.431011e-01 | 0.844 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 2.822661e-01 | 0.549 | 0 | 0 |
| RUNX3 regulates RUNX1-mediated transcription | R-HSA-8951911 | 2.822661e-01 | 0.549 | 0 | 0 |
| TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 2.822661e-01 | 0.549 | 0 | 0 |
| TGFBR2 Kinase Domain Mutants in Cancer | R-HSA-3645790 | 2.822661e-01 | 0.549 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 2.822661e-01 | 0.549 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 2.822661e-01 | 0.549 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 2.822661e-01 | 0.549 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 1.719648e-01 | 0.765 | 0 | 0 |
| Autointegration results in viral DNA circles | R-HSA-177539 | 1.719648e-01 | 0.765 | 0 | 0 |
| Branched-chain ketoacid dehydrogenase kinase deficiency | R-HSA-9912481 | 1.719648e-01 | 0.765 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 1.300144e-01 | 0.886 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 1.300144e-01 | 0.886 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 1.300144e-01 | 0.886 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 2.016625e-01 | 0.695 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 2.016625e-01 | 0.695 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 2.016625e-01 | 0.695 | 0 | 0 |
| Signaling by plasma membrane FGFR1 fusions | R-HSA-8853336 | 3.393846e-01 | 0.469 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 3.393846e-01 | 0.469 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 1.489457e-01 | 0.827 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 1.489457e-01 | 0.827 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 1.489457e-01 | 0.827 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 1.489457e-01 | 0.827 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 1.489457e-01 | 0.827 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 1.489457e-01 | 0.827 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 1.489457e-01 | 0.827 | 0 | 0 |
| Regulation of NPAS4 mRNA translation | R-HSA-9768778 | 2.318791e-01 | 0.635 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 2.318791e-01 | 0.635 | 0 | 0 |
| MET receptor recycling | R-HSA-8875656 | 2.318791e-01 | 0.635 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 1.686942e-01 | 0.773 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 1.686942e-01 | 0.773 | 0 | 0 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | R-HSA-9661069 | 1.686942e-01 | 0.773 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 1.263264e-01 | 0.899 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 1.263264e-01 | 0.899 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 1.263264e-01 | 0.899 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 1.263264e-01 | 0.899 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 1.891438e-01 | 0.723 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 1.891438e-01 | 0.723 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 2.623442e-01 | 0.581 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 2.623442e-01 | 0.581 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 2.623442e-01 | 0.581 | 1 | 1 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 3.919606e-01 | 0.407 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 3.919606e-01 | 0.407 | 0 | 0 |
| Drug-mediated inhibition of CDK4/CDK6 activity | R-HSA-9754119 | 3.919606e-01 | 0.407 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 3.919606e-01 | 0.407 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 3.919606e-01 | 0.407 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 1.560734e-01 | 0.807 | 0 | 0 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | R-HSA-8948700 | 2.101813e-01 | 0.677 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 2.101813e-01 | 0.677 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 1.718371e-01 | 0.765 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 1.422728e-01 | 0.847 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 1.422728e-01 | 0.847 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 1.422728e-01 | 0.847 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 1.422728e-01 | 0.847 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 2.316972e-01 | 0.635 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 2.316972e-01 | 0.635 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 2.316972e-01 | 0.635 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 1.881234e-01 | 0.726 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 1.881234e-01 | 0.726 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 1.290805e-01 | 0.889 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 2.535867e-01 | 0.596 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 3.231328e-01 | 0.491 | 0 | 0 |
| Regulation of CDH11 mRNA translation by microRNAs | R-HSA-9759811 | 3.231328e-01 | 0.491 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 4.403551e-01 | 0.356 | 0 | 0 |
| FGFR1c and Klotho ligand binding and activation | R-HSA-190374 | 4.403551e-01 | 0.356 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 4.403551e-01 | 0.356 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 4.403551e-01 | 0.356 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 2.757503e-01 | 0.559 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 3.530960e-01 | 0.452 | 0 | 0 |
| Signaling by activated point mutants of FGFR1 | R-HSA-1839122 | 3.530960e-01 | 0.452 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 1.390125e-01 | 0.857 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 1.656637e-01 | 0.781 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 1.656637e-01 | 0.781 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 1.656637e-01 | 0.781 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 2.574007e-01 | 0.589 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 1.986610e-01 | 0.702 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 1.407704e-01 | 0.851 | 1 | 1 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 1.407704e-01 | 0.851 | 1 | 1 |
| Striated Muscle Contraction | R-HSA-390522 | 2.402027e-01 | 0.619 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 3.205312e-01 | 0.494 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 3.205312e-01 | 0.494 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 3.825797e-01 | 0.417 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 3.825797e-01 | 0.417 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 3.825797e-01 | 0.417 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 3.825797e-01 | 0.417 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 3.825797e-01 | 0.417 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 4.849005e-01 | 0.314 | 0 | 0 |
| Inhibition of Signaling by Overexpressed EGFR | R-HSA-5638303 | 4.849005e-01 | 0.314 | 0 | 0 |
| Signaling by Overexpressed Wild-Type EGFR in Cancer | R-HSA-5638302 | 4.849005e-01 | 0.314 | 0 | 0 |
| Signaling by MAPK mutants | R-HSA-9652817 | 4.849005e-01 | 0.314 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 4.849005e-01 | 0.314 | 0 | 0 |
| Loss-of-function mutations in DLD cause MSUD3/DLDD | R-HSA-9907570 | 4.849005e-01 | 0.314 | 0 | 0 |
| Loss-of-function mutations in DBT cause MSUD2 | R-HSA-9865113 | 4.849005e-01 | 0.314 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 1.665348e-01 | 0.778 | 1 | 1 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 2.074242e-01 | 0.683 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 3.121895e-01 | 0.506 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 3.121895e-01 | 0.506 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 2.337790e-01 | 0.631 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 1.713813e-01 | 0.766 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 3.307178e-01 | 0.481 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 3.307178e-01 | 0.481 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 3.026262e-01 | 0.519 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 1.918521e-01 | 0.717 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 2.046515e-01 | 0.689 | 1 | 1 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 2.342010e-01 | 0.630 | 1 | 1 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 3.492998e-01 | 0.457 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 3.492998e-01 | 0.457 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 4.396760e-01 | 0.357 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 4.396760e-01 | 0.357 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 5.259028e-01 | 0.279 | 0 | 0 |
| Signaling by LTK in cancer | R-HSA-9842640 | 5.259028e-01 | 0.279 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 5.259028e-01 | 0.279 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 5.259028e-01 | 0.279 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 5.259028e-01 | 0.279 | 0 | 0 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 5.259028e-01 | 0.279 | 0 | 0 |
| Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | R-HSA-9865125 | 5.259028e-01 | 0.279 | 0 | 0 |
| H139Hfs13* PPM1K causes a mild variant of MSUD | R-HSA-9912529 | 5.259028e-01 | 0.279 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 2.551620e-01 | 0.593 | 1 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 4.096773e-01 | 0.388 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 4.096773e-01 | 0.388 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 4.096773e-01 | 0.388 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 4.671224e-01 | 0.331 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 4.671224e-01 | 0.331 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 4.671224e-01 | 0.331 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 4.671224e-01 | 0.331 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 3.100875e-01 | 0.509 | 0 | 0 |
| Regulation of PTEN mRNA translation | R-HSA-8943723 | 4.314860e-01 | 0.365 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 2.881972e-01 | 0.540 | 1 | 1 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 4.529940e-01 | 0.344 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 4.937520e-01 | 0.306 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 4.937520e-01 | 0.306 | 0 | 0 |
| Defective GALNT12 causes CRCS1 | R-HSA-5083636 | 4.937520e-01 | 0.306 | 0 | 0 |
| Defective GALNT3 causes HFTC | R-HSA-5083625 | 4.937520e-01 | 0.306 | 0 | 0 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | 5.636434e-01 | 0.249 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 5.636434e-01 | 0.249 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 5.636434e-01 | 0.249 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 5.636434e-01 | 0.249 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | R-HSA-9031525 | 5.636434e-01 | 0.249 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose | R-HSA-9031528 | 5.636434e-01 | 0.249 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 5.636434e-01 | 0.249 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 4.415478e-01 | 0.355 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 5.195209e-01 | 0.284 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 4.477711e-01 | 0.349 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 4.477711e-01 | 0.349 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 4.774583e-01 | 0.321 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 4.636407e-01 | 0.334 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 4.793713e-01 | 0.319 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 5.152935e-01 | 0.288 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 5.443974e-01 | 0.264 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 5.443974e-01 | 0.264 | 0 | 0 |
| Defective C1GALT1C1 causes TNPS | R-HSA-5083632 | 5.443974e-01 | 0.264 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 5.352041e-01 | 0.271 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 5.352041e-01 | 0.271 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 5.546414e-01 | 0.256 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 5.546414e-01 | 0.256 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 5.463107e-01 | 0.263 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 5.463107e-01 | 0.263 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 5.552938e-01 | 0.255 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 5.698216e-01 | 0.244 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 5.698216e-01 | 0.244 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 2.981126e-01 | 0.526 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 1.801270e-01 | 0.744 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 2.378618e-01 | 0.624 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 5.443974e-01 | 0.264 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 5.443974e-01 | 0.264 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 3.509179e-01 | 0.455 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 5.735848e-01 | 0.241 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 3.328896e-01 | 0.478 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 1.881234e-01 | 0.726 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 1.986610e-01 | 0.702 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 5.275819e-01 | 0.278 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 5.627787e-01 | 0.250 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 2.074242e-01 | 0.683 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 2.104237e-01 | 0.677 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 5.735848e-01 | 0.241 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 1.518746e-01 | 0.819 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 3.509179e-01 | 0.455 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 4.415478e-01 | 0.355 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 4.437386e-01 | 0.353 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 1.169471e-01 | 0.932 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 4.683723e-01 | 0.329 | 0 | 0 |
| FGFR1 ligand binding and activation | R-HSA-190242 | 5.683604e-01 | 0.245 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 1.560734e-01 | 0.807 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 2.928273e-01 | 0.533 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 2.928273e-01 | 0.533 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 3.833482e-01 | 0.416 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 5.735848e-01 | 0.241 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 2.535867e-01 | 0.596 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 3.205312e-01 | 0.494 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 2.016625e-01 | 0.695 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 2.318791e-01 | 0.635 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 2.623442e-01 | 0.581 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 2.623442e-01 | 0.581 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 2.928273e-01 | 0.533 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 2.316972e-01 | 0.635 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 3.231328e-01 | 0.491 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 2.104237e-01 | 0.677 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 3.347437e-01 | 0.475 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 1.422728e-01 | 0.847 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 1.819551e-01 | 0.740 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 2.316972e-01 | 0.635 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 2.316972e-01 | 0.635 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 1.656637e-01 | 0.781 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 2.867452e-01 | 0.543 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 4.925443e-01 | 0.308 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 2.867452e-01 | 0.543 | 0 | 0 |
| Nef mediated downregulation of MHC class I complex cell surface expression | R-HSA-164940 | 2.318791e-01 | 0.635 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 3.919606e-01 | 0.407 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in BCR signaling | R-HSA-8939245 | 4.403551e-01 | 0.356 | 0 | 0 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 3.205312e-01 | 0.494 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 3.825797e-01 | 0.417 | 1 | 1 |
| GLI proteins bind promoters of Hh responsive genes to promote transcription | R-HSA-5635851 | 4.849005e-01 | 0.314 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 3.307178e-01 | 0.481 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 3.678912e-01 | 0.434 | 0 | 0 |
| Telomere C-strand synthesis initiation | R-HSA-174430 | 4.671224e-01 | 0.331 | 0 | 0 |
| Netrin mediated repulsion signals | R-HSA-418886 | 5.636434e-01 | 0.249 | 0 | 0 |
| NOSTRIN mediated eNOS trafficking | R-HSA-203641 | 5.636434e-01 | 0.249 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 3.561216e-01 | 0.448 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 4.774583e-01 | 0.321 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 2.316972e-01 | 0.635 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 2.754815e-01 | 0.560 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 1.473232e-01 | 0.832 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 1.593820e-01 | 0.798 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 3.530960e-01 | 0.452 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 2.574007e-01 | 0.589 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 2.139004e-01 | 0.670 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 3.940819e-01 | 0.404 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 5.443974e-01 | 0.264 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 5.463107e-01 | 0.263 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 2.104237e-01 | 0.677 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 3.013295e-01 | 0.521 | 0 | 0 |
| Post-transcriptional silencing by small RNAs | R-HSA-426496 | 1.154370e-01 | 0.938 | 0 | 0 |
| Formation of the posterior neural plate | R-HSA-9832991 | 3.231328e-01 | 0.491 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 2.757503e-01 | 0.559 | 0 | 0 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | R-HSA-113501 | 3.530960e-01 | 0.452 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 3.205312e-01 | 0.494 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 5.636434e-01 | 0.249 | 0 | 0 |
| PTK6 Expression | R-HSA-8849473 | 5.636434e-01 | 0.249 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 4.741566e-01 | 0.324 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 5.195209e-01 | 0.284 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 4.949345e-01 | 0.305 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 3.727379e-01 | 0.429 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 5.683604e-01 | 0.245 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 2.929625e-01 | 0.533 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 2.441005e-01 | 0.612 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 1.267221e-01 | 0.897 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 5.452768e-01 | 0.263 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 3.465436e-01 | 0.460 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 2.521581e-01 | 0.598 | 1 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 2.924448e-01 | 0.534 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 3.825797e-01 | 0.417 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 3.669350e-01 | 0.435 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 1.668102e-01 | 0.778 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 3.355611e-01 | 0.474 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 3.355611e-01 | 0.474 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 3.355611e-01 | 0.474 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 3.355611e-01 | 0.474 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 2.574007e-01 | 0.589 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 2.512562e-01 | 0.600 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 4.114704e-01 | 0.386 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 4.949345e-01 | 0.305 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 1.891438e-01 | 0.723 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 3.919606e-01 | 0.407 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 1.572746e-01 | 0.803 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 2.754815e-01 | 0.560 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 1.960091e-01 | 0.708 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 3.186362e-01 | 0.497 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 5.086859e-01 | 0.294 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 2.535867e-01 | 0.596 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 3.530960e-01 | 0.452 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 2.754815e-01 | 0.560 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 3.205312e-01 | 0.494 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 5.259028e-01 | 0.279 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 4.596057e-01 | 0.338 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 1.489457e-01 | 0.827 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 1.251185e-01 | 0.903 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 2.033677e-01 | 0.692 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 4.179840e-01 | 0.379 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 2.512562e-01 | 0.600 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 1.263680e-01 | 0.898 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 5.642231e-01 | 0.249 | 1 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 2.101813e-01 | 0.677 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 4.016794e-01 | 0.396 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 4.949345e-01 | 0.305 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 1.508165e-01 | 0.822 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 1.413024e-01 | 0.850 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 4.423547e-01 | 0.354 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 1.251185e-01 | 0.903 | 0 | 0 |
| Inhibition of PKR | R-HSA-169131 | 1.527995e-01 | 0.816 | 0 | 0 |
| RUNX2 regulates chondrocyte maturation | R-HSA-8941284 | 1.154370e-01 | 0.938 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 2.822661e-01 | 0.549 | 0 | 0 |
| Loss of Function of TGFBR2 in Cancer | R-HSA-3642278 | 2.822661e-01 | 0.549 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 1.300144e-01 | 0.886 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 1.300144e-01 | 0.886 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 2.016625e-01 | 0.695 | 0 | 0 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | R-HSA-9659787 | 1.686942e-01 | 0.773 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 2.623442e-01 | 0.581 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 2.623442e-01 | 0.581 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 2.928273e-01 | 0.533 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 4.403551e-01 | 0.356 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 1.260221e-01 | 0.900 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 1.508165e-01 | 0.822 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 2.220451e-01 | 0.654 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 1.622590e-01 | 0.790 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 1.986610e-01 | 0.702 | 0 | 0 |
| CDC6 association with the ORC:origin complex | R-HSA-68689 | 4.849005e-01 | 0.314 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 4.849005e-01 | 0.314 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 4.849005e-01 | 0.314 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 4.114704e-01 | 0.386 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 4.671224e-01 | 0.331 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 3.487845e-01 | 0.457 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 4.529940e-01 | 0.344 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 3.381733e-01 | 0.471 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 5.683604e-01 | 0.245 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 4.636539e-01 | 0.334 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 5.172656e-01 | 0.286 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 1.407704e-01 | 0.851 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 1.794077e-01 | 0.746 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 4.611453e-01 | 0.336 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 5.683604e-01 | 0.245 | 0 | 0 |
| S Phase | R-HSA-69242 | 3.066905e-01 | 0.513 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 2.107195e-01 | 0.676 | 1 | 0 |
| PLC beta mediated events | R-HSA-112043 | 3.487845e-01 | 0.457 | 0 | 0 |
| Synthesis of pyrophosphates in the cytosol | R-HSA-1855167 | 4.314860e-01 | 0.365 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 2.754815e-01 | 0.560 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 1.490992e-01 | 0.827 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 2.543414e-01 | 0.595 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 2.377386e-01 | 0.624 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 5.636434e-01 | 0.249 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 4.520583e-01 | 0.345 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 1.251219e-01 | 0.903 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 5.698216e-01 | 0.244 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 2.788912e-01 | 0.555 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 2.623442e-01 | 0.581 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 2.928273e-01 | 0.533 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 3.429797e-01 | 0.465 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 2.512562e-01 | 0.600 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 3.026262e-01 | 0.519 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 2.788912e-01 | 0.555 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 4.949345e-01 | 0.305 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 3.645135e-01 | 0.438 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 2.162135e-01 | 0.665 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 2.316972e-01 | 0.635 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 5.683604e-01 | 0.245 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 3.753795e-01 | 0.426 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 3.753795e-01 | 0.426 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 1.443171e-01 | 0.841 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 5.496909e-01 | 0.260 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 3.653648e-01 | 0.437 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 1.188200e-01 | 0.925 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 2.104237e-01 | 0.677 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 1.431011e-01 | 0.844 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 1.431011e-01 | 0.844 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 1.686942e-01 | 0.773 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 2.623442e-01 | 0.581 | 0 | 0 |
| Activation of NOXA and translocation to mitochondria | R-HSA-111448 | 3.919606e-01 | 0.407 | 0 | 0 |
| Muscarinic acetylcholine receptors | R-HSA-390648 | 4.403551e-01 | 0.356 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 3.825797e-01 | 0.417 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 3.825797e-01 | 0.417 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 3.825797e-01 | 0.417 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 3.825797e-01 | 0.417 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 4.849005e-01 | 0.314 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 4.396760e-01 | 0.357 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 5.636434e-01 | 0.249 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 2.956242e-01 | 0.529 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 5.073314e-01 | 0.295 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 5.452768e-01 | 0.263 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 5.496909e-01 | 0.260 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 2.658403e-01 | 0.575 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 3.671290e-01 | 0.435 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 1.192383e-01 | 0.924 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 2.574007e-01 | 0.589 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 5.181168e-01 | 0.286 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 3.121895e-01 | 0.506 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 3.649428e-01 | 0.438 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 4.949432e-01 | 0.305 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 4.690645e-01 | 0.329 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 5.630132e-01 | 0.249 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 4.287145e-01 | 0.368 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 2.757503e-01 | 0.559 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 5.195209e-01 | 0.284 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 2.528661e-01 | 0.597 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 3.328896e-01 | 0.478 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 3.355611e-01 | 0.474 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 3.329277e-01 | 0.478 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 2.574007e-01 | 0.589 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 3.887185e-01 | 0.410 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 4.258054e-01 | 0.371 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 4.258054e-01 | 0.371 | 0 | 0 |
| Inhibition of membrane repair | R-HSA-9635644 | 2.202131e-01 | 0.657 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 1.431011e-01 | 0.844 | 0 | 0 |
| DSCAM interactions | R-HSA-376172 | 2.822661e-01 | 0.549 | 0 | 0 |
| Integration of viral DNA into host genomic DNA | R-HSA-175567 | 1.719648e-01 | 0.765 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 1.489457e-01 | 0.827 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 2.928273e-01 | 0.533 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 1.682938e-01 | 0.774 | 0 | 0 |
| Reduction of cytosolic Ca++ levels | R-HSA-418359 | 3.530960e-01 | 0.452 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 3.530960e-01 | 0.452 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 1.862012e-01 | 0.730 | 0 | 0 |
| Signalling to p38 via RIT and RIN | R-HSA-187706 | 4.849005e-01 | 0.314 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 4.849005e-01 | 0.314 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 3.653648e-01 | 0.437 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 3.355611e-01 | 0.474 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 4.049366e-01 | 0.393 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 4.049366e-01 | 0.393 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 1.733282e-01 | 0.761 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 5.636434e-01 | 0.249 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 3.554134e-01 | 0.449 | 1 | 1 |
| Disorders of Developmental Biology | R-HSA-9675151 | 5.195209e-01 | 0.284 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 1.422728e-01 | 0.847 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 1.551398e-01 | 0.809 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 4.611453e-01 | 0.336 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 5.546414e-01 | 0.256 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 3.835171e-01 | 0.416 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 3.231328e-01 | 0.491 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 4.049366e-01 | 0.393 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 5.152935e-01 | 0.288 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 5.698763e-01 | 0.244 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 2.466265e-01 | 0.608 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 4.947112e-01 | 0.306 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 2.101813e-01 | 0.677 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 3.429797e-01 | 0.465 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 5.225158e-01 | 0.282 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 2.220451e-01 | 0.654 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 1.676546e-01 | 0.776 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 4.933277e-01 | 0.307 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 2.623442e-01 | 0.581 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 3.530960e-01 | 0.452 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 4.849005e-01 | 0.314 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 3.347437e-01 | 0.475 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 4.049366e-01 | 0.393 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 4.937520e-01 | 0.306 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 4.231709e-01 | 0.373 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 4.039350e-01 | 0.394 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 2.127089e-01 | 0.672 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 3.653648e-01 | 0.437 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 2.867452e-01 | 0.543 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 1.181790e-01 | 0.927 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 3.492998e-01 | 0.457 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 5.327585e-01 | 0.273 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 5.086859e-01 | 0.294 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 3.833482e-01 | 0.416 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 4.096773e-01 | 0.388 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 5.152935e-01 | 0.288 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 4.774583e-01 | 0.321 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 1.154370e-01 | 0.938 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 3.231328e-01 | 0.491 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 3.876181e-01 | 0.412 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 3.876181e-01 | 0.412 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 4.396760e-01 | 0.357 | 0 | 0 |
| Formation of the anterior neural plate | R-HSA-9823739 | 4.671224e-01 | 0.331 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 4.671224e-01 | 0.331 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 5.443974e-01 | 0.264 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 2.337790e-01 | 0.631 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 3.224090e-01 | 0.492 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 2.963871e-01 | 0.528 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 5.546414e-01 | 0.256 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 5.152935e-01 | 0.288 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 3.794907e-01 | 0.421 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 1.263264e-01 | 0.899 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 5.284035e-01 | 0.277 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 2.928273e-01 | 0.533 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 2.316972e-01 | 0.635 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 1.881234e-01 | 0.726 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 3.347437e-01 | 0.475 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 3.504047e-01 | 0.455 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 5.004885e-01 | 0.301 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 1.881234e-01 | 0.726 | 0 | 0 |
| TYSND1 cleaves peroxisomal proteins | R-HSA-9033500 | 4.849005e-01 | 0.314 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 4.096773e-01 | 0.388 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 4.671224e-01 | 0.331 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 4.415478e-01 | 0.355 | 0 | 0 |
| Nectin/Necl trans heterodimerization | R-HSA-420597 | 4.403551e-01 | 0.356 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 2.051600e-01 | 0.688 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 5.636434e-01 | 0.249 | 0 | 0 |
| TGFBR3 regulates TGF-beta signaling | R-HSA-9839389 | 5.636434e-01 | 0.249 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 4.937520e-01 | 0.306 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 5.152935e-01 | 0.288 | 0 | 0 |
| Nephron development | R-HSA-9831926 | 5.683604e-01 | 0.245 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 2.928273e-01 | 0.533 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 2.296123e-01 | 0.639 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 1.653293e-01 | 0.782 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 3.492998e-01 | 0.457 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 5.692352e-01 | 0.245 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 2.778877e-01 | 0.556 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 5.774746e-01 | 0.238 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 5.789142e-01 | 0.237 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 5.789142e-01 | 0.237 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 5.789142e-01 | 0.237 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 5.789142e-01 | 0.237 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 5.789142e-01 | 0.237 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 5.827352e-01 | 0.235 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 5.873250e-01 | 0.231 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 5.873250e-01 | 0.231 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 5.891363e-01 | 0.230 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 5.913975e-01 | 0.228 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 5.913975e-01 | 0.228 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 5.913975e-01 | 0.228 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 5.913975e-01 | 0.228 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 5.913975e-01 | 0.228 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 5.920173e-01 | 0.228 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 5.981179e-01 | 0.223 | 0 | 0 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 5.983818e-01 | 0.223 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 5.983818e-01 | 0.223 | 0 | 0 |
| Activated NTRK2 signals through PI3K | R-HSA-9028335 | 5.983818e-01 | 0.223 | 0 | 0 |
| FGFR1b ligand binding and activation | R-HSA-190370 | 5.983818e-01 | 0.223 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 5.983818e-01 | 0.223 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 5.983818e-01 | 0.223 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 5.983818e-01 | 0.223 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 5.983818e-01 | 0.223 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 5.983818e-01 | 0.223 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 5.983818e-01 | 0.223 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 5.983818e-01 | 0.223 | 0 | 0 |
| Alpha-defensins | R-HSA-1462054 | 5.983818e-01 | 0.223 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 5.983818e-01 | 0.223 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 5.983818e-01 | 0.223 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 6.018003e-01 | 0.221 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 6.055614e-01 | 0.218 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 6.101356e-01 | 0.215 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 6.118663e-01 | 0.213 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 6.118663e-01 | 0.213 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 6.118663e-01 | 0.213 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 6.130188e-01 | 0.213 | 0 | 0 |
| Regulation of PD-L1(CD274) translation | R-HSA-9909620 | 6.135044e-01 | 0.212 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 6.135044e-01 | 0.212 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 6.135044e-01 | 0.212 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 6.135044e-01 | 0.212 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 6.135044e-01 | 0.212 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 6.135044e-01 | 0.212 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 6.135044e-01 | 0.212 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 6.135044e-01 | 0.212 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 6.135044e-01 | 0.212 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 6.135044e-01 | 0.212 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 6.252002e-01 | 0.204 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 6.252002e-01 | 0.204 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 6.252002e-01 | 0.204 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 6.265919e-01 | 0.203 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 6.273001e-01 | 0.203 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 6.273001e-01 | 0.203 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 6.273001e-01 | 0.203 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 6.303566e-01 | 0.200 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 6.303566e-01 | 0.200 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 6.303566e-01 | 0.200 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 6.303566e-01 | 0.200 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 6.303566e-01 | 0.200 | 0 | 0 |
| Regulation of NPAS4 gene transcription | R-HSA-9768777 | 6.303566e-01 | 0.200 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 6.303566e-01 | 0.200 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 6.303566e-01 | 0.200 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 6.306845e-01 | 0.200 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 6.346832e-01 | 0.197 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 6.346832e-01 | 0.197 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 6.346832e-01 | 0.197 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 6.346832e-01 | 0.197 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 6.346832e-01 | 0.197 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 6.346832e-01 | 0.197 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 6.354094e-01 | 0.197 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 6.356753e-01 | 0.197 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 6.385223e-01 | 0.195 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 6.385223e-01 | 0.195 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 6.386472e-01 | 0.195 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 6.398896e-01 | 0.194 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 6.429232e-01 | 0.192 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 6.441337e-01 | 0.191 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 6.451584e-01 | 0.190 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 6.495151e-01 | 0.187 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 6.504679e-01 | 0.187 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 6.541974e-01 | 0.184 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 6.541974e-01 | 0.184 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 6.549414e-01 | 0.184 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 6.549414e-01 | 0.184 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 6.549414e-01 | 0.184 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 6.559293e-01 | 0.183 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 6.597875e-01 | 0.181 | 0 | 0 |
| DNA replication initiation | R-HSA-68952 | 6.597875e-01 | 0.181 | 0 | 0 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | R-HSA-5140745 | 6.597875e-01 | 0.181 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 6.597875e-01 | 0.181 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 6.597875e-01 | 0.181 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 6.597875e-01 | 0.181 | 0 | 0 |
| Ion influx/efflux at host-pathogen interface | R-HSA-6803544 | 6.597875e-01 | 0.181 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 6.597875e-01 | 0.181 | 0 | 0 |
| Receptor Mediated Mitophagy | R-HSA-8934903 | 6.597875e-01 | 0.181 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 6.597875e-01 | 0.181 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 6.604221e-01 | 0.180 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 6.604221e-01 | 0.180 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 6.614963e-01 | 0.179 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 6.620495e-01 | 0.179 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 6.632347e-01 | 0.178 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 6.681188e-01 | 0.175 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 6.681188e-01 | 0.175 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 6.681188e-01 | 0.175 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 6.681188e-01 | 0.175 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 6.719286e-01 | 0.173 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 6.732366e-01 | 0.172 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 6.742914e-01 | 0.171 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 6.742914e-01 | 0.171 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 6.742914e-01 | 0.171 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 6.761639e-01 | 0.170 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 6.761639e-01 | 0.170 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 6.778075e-01 | 0.169 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 6.790675e-01 | 0.168 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 6.807830e-01 | 0.167 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 6.816507e-01 | 0.166 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 6.844798e-01 | 0.165 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 6.844798e-01 | 0.165 | 0 | 0 |
| Presynaptic depolarization and calcium channel opening | R-HSA-112308 | 6.868767e-01 | 0.163 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 6.868767e-01 | 0.163 | 0 | 0 |
| vRNA Synthesis | R-HSA-192814 | 6.868767e-01 | 0.163 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 6.868767e-01 | 0.163 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 6.868767e-01 | 0.163 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 6.868767e-01 | 0.163 | 0 | 0 |
| Synthesis of PIPs at the ER membrane | R-HSA-1483248 | 6.868767e-01 | 0.163 | 0 | 0 |
| Transport of RCbl within the body | R-HSA-9758890 | 6.868767e-01 | 0.163 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 6.868767e-01 | 0.163 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 6.875144e-01 | 0.163 | 1 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 6.883079e-01 | 0.162 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 6.883079e-01 | 0.162 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 6.913596e-01 | 0.160 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 6.924342e-01 | 0.160 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 6.924342e-01 | 0.160 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 6.927494e-01 | 0.159 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 6.927494e-01 | 0.159 | 0 | 0 |
| Termination of O-glycan biosynthesis | R-HSA-977068 | 6.927494e-01 | 0.159 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 6.927494e-01 | 0.159 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 6.927494e-01 | 0.159 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 6.927494e-01 | 0.159 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 6.988274e-01 | 0.156 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 7.060118e-01 | 0.151 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 7.060118e-01 | 0.151 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 7.075388e-01 | 0.150 | 0 | 0 |
| SHC-mediated cascade:FGFR1 | R-HSA-5654688 | 7.103346e-01 | 0.149 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 7.103346e-01 | 0.149 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 7.118104e-01 | 0.148 | 0 | 0 |
| POLB-Dependent Long Patch Base Excision Repair | R-HSA-110362 | 7.118104e-01 | 0.148 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 7.118104e-01 | 0.148 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 7.118104e-01 | 0.148 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 7.118104e-01 | 0.148 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 7.132109e-01 | 0.147 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 7.162534e-01 | 0.145 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 7.201250e-01 | 0.143 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 7.224538e-01 | 0.141 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 7.226378e-01 | 0.141 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 7.270691e-01 | 0.138 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 7.270691e-01 | 0.138 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 7.270691e-01 | 0.138 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 7.270942e-01 | 0.138 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 7.318603e-01 | 0.136 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 7.337051e-01 | 0.134 | 0 | 0 |
| Maple Syrup Urine Disease | R-HSA-9865114 | 7.347600e-01 | 0.134 | 0 | 0 |
| Variant SLC6A14 may confer susceptibility towards obesity | R-HSA-5619094 | 7.347600e-01 | 0.134 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 7.347600e-01 | 0.134 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 7.347600e-01 | 0.134 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 7.347600e-01 | 0.134 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 7.347600e-01 | 0.134 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 7.347600e-01 | 0.134 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 7.347600e-01 | 0.134 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 7.347600e-01 | 0.134 | 0 | 0 |
| Erythrocytes take up oxygen and release carbon dioxide | R-HSA-1247673 | 7.347600e-01 | 0.134 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 7.347600e-01 | 0.134 | 0 | 0 |
| Interleukin-15 signaling | R-HSA-8983432 | 7.347600e-01 | 0.134 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 7.398672e-01 | 0.131 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 7.399650e-01 | 0.131 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 7.408078e-01 | 0.130 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 7.429768e-01 | 0.129 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 7.429768e-01 | 0.129 | 0 | 0 |
| Diseases of branched-chain amino acid catabolism | R-HSA-9865118 | 7.429768e-01 | 0.129 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 7.429768e-01 | 0.129 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 7.429768e-01 | 0.129 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 7.434379e-01 | 0.129 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 7.434379e-01 | 0.129 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 7.442193e-01 | 0.128 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 7.467597e-01 | 0.127 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 7.467597e-01 | 0.127 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 7.467597e-01 | 0.127 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 7.491380e-01 | 0.125 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 7.524751e-01 | 0.124 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 7.532086e-01 | 0.123 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 7.538350e-01 | 0.123 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 7.546309e-01 | 0.122 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 7.546309e-01 | 0.122 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 7.550722e-01 | 0.122 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | R-HSA-9029558 | 7.558834e-01 | 0.122 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 7.558834e-01 | 0.122 | 0 | 0 |
| FGFR1c ligand binding and activation | R-HSA-190373 | 7.558834e-01 | 0.122 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 7.558834e-01 | 0.122 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 7.558834e-01 | 0.122 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 7.558834e-01 | 0.122 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 7.558834e-01 | 0.122 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 7.564598e-01 | 0.121 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 7.580831e-01 | 0.120 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 7.580831e-01 | 0.120 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 7.580831e-01 | 0.120 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 7.592974e-01 | 0.120 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 7.592974e-01 | 0.120 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 7.605417e-01 | 0.119 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 7.641441e-01 | 0.117 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 7.684195e-01 | 0.114 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 7.690435e-01 | 0.114 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 7.713280e-01 | 0.113 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 7.713280e-01 | 0.113 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 7.713280e-01 | 0.113 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 7.724149e-01 | 0.112 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 7.724149e-01 | 0.112 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 7.729650e-01 | 0.112 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 7.732357e-01 | 0.112 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 7.732357e-01 | 0.112 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 7.753256e-01 | 0.111 | 0 | 0 |
| BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | R-HSA-9859138 | 7.753256e-01 | 0.111 | 0 | 0 |
| Synthesis of IPs in the nucleus | R-HSA-1855191 | 7.753256e-01 | 0.111 | 0 | 0 |
| Retrograde neurotrophin signalling | R-HSA-177504 | 7.753256e-01 | 0.111 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 7.753256e-01 | 0.111 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 7.753256e-01 | 0.111 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 7.753256e-01 | 0.111 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 7.753256e-01 | 0.111 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 7.758803e-01 | 0.110 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 7.758803e-01 | 0.110 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 7.815368e-01 | 0.107 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 7.820961e-01 | 0.107 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 7.824874e-01 | 0.107 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 7.824874e-01 | 0.107 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 7.828620e-01 | 0.106 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 7.828620e-01 | 0.106 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 7.859996e-01 | 0.105 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 7.859996e-01 | 0.105 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 7.859996e-01 | 0.105 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 7.859996e-01 | 0.105 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 7.898798e-01 | 0.102 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 7.909262e-01 | 0.102 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 7.909262e-01 | 0.102 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 7.914445e-01 | 0.102 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 7.932205e-01 | 0.101 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 7.932205e-01 | 0.101 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 7.932205e-01 | 0.101 | 0 | 0 |
| Translesion synthesis by REV1 | R-HSA-110312 | 7.932205e-01 | 0.101 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 7.932205e-01 | 0.101 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 7.932205e-01 | 0.101 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 7.932205e-01 | 0.101 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 7.932205e-01 | 0.101 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 7.956499e-01 | 0.099 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 7.974526e-01 | 0.098 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 7.974526e-01 | 0.098 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 7.974526e-01 | 0.098 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 7.974526e-01 | 0.098 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 7.988652e-01 | 0.098 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 7.991958e-01 | 0.097 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 7.993951e-01 | 0.097 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 7.993951e-01 | 0.097 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 8.044867e-01 | 0.094 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 8.048164e-01 | 0.094 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 8.049952e-01 | 0.094 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 8.049952e-01 | 0.094 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 8.049952e-01 | 0.094 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 8.084906e-01 | 0.092 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 8.096911e-01 | 0.092 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 8.096911e-01 | 0.092 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 8.096911e-01 | 0.092 | 0 | 0 |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | R-HSA-434316 | 8.096911e-01 | 0.092 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 8.096911e-01 | 0.092 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 8.096911e-01 | 0.092 | 0 | 0 |
| Differentiation of T cells | R-HSA-9945266 | 8.096911e-01 | 0.092 | 0 | 0 |
| Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | R-HSA-9942503 | 8.096911e-01 | 0.092 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 8.096911e-01 | 0.092 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 8.096911e-01 | 0.092 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 8.110402e-01 | 0.091 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 8.110402e-01 | 0.091 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 8.112381e-01 | 0.091 | 1 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 8.117663e-01 | 0.091 | 0 | 0 |
| Kinesins | R-HSA-983189 | 8.139900e-01 | 0.089 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 8.139900e-01 | 0.089 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 8.146021e-01 | 0.089 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 8.146021e-01 | 0.089 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 8.186356e-01 | 0.087 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 8.195350e-01 | 0.086 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 8.212360e-01 | 0.086 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 8.225528e-01 | 0.085 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 8.226418e-01 | 0.085 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 8.248506e-01 | 0.084 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 8.248506e-01 | 0.084 | 0 | 0 |
| Phase 2 - plateau phase | R-HSA-5576893 | 8.248506e-01 | 0.084 | 0 | 0 |
| Heme assimilation | R-HSA-9927020 | 8.248506e-01 | 0.084 | 0 | 0 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 8.248506e-01 | 0.084 | 0 | 0 |
| tRNA modification in the mitochondrion | R-HSA-6787450 | 8.248506e-01 | 0.084 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 8.248506e-01 | 0.084 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 8.309583e-01 | 0.080 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 8.309828e-01 | 0.080 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 8.319575e-01 | 0.080 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 8.334314e-01 | 0.079 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 8.334314e-01 | 0.079 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 8.334314e-01 | 0.079 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 8.388034e-01 | 0.076 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 8.388034e-01 | 0.076 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 8.388034e-01 | 0.076 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 8.389474e-01 | 0.076 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 8.389474e-01 | 0.076 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 8.423164e-01 | 0.075 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 8.423164e-01 | 0.075 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 8.437037e-01 | 0.074 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 8.437037e-01 | 0.074 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 8.447447e-01 | 0.073 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 8.447447e-01 | 0.073 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 8.462601e-01 | 0.072 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 8.462601e-01 | 0.072 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 8.466174e-01 | 0.072 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 8.479170e-01 | 0.072 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 8.507222e-01 | 0.070 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 8.507222e-01 | 0.070 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 8.507222e-01 | 0.070 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 8.507222e-01 | 0.070 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 8.516455e-01 | 0.070 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 8.516455e-01 | 0.070 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 8.516455e-01 | 0.070 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 8.516455e-01 | 0.070 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 8.516455e-01 | 0.070 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 8.516455e-01 | 0.070 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 8.516455e-01 | 0.070 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 8.516455e-01 | 0.070 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 8.516455e-01 | 0.070 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 8.530254e-01 | 0.069 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 8.530254e-01 | 0.069 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 8.533975e-01 | 0.069 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 8.533975e-01 | 0.069 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 8.533975e-01 | 0.069 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 8.533975e-01 | 0.069 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 8.533975e-01 | 0.069 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 8.533975e-01 | 0.069 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 8.533975e-01 | 0.069 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 8.533975e-01 | 0.069 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 8.533975e-01 | 0.069 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 8.533975e-01 | 0.069 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 8.538388e-01 | 0.069 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 8.541597e-01 | 0.068 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 8.541775e-01 | 0.068 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 8.587348e-01 | 0.066 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 8.595410e-01 | 0.066 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 8.595591e-01 | 0.066 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 8.595591e-01 | 0.066 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 8.625395e-01 | 0.064 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 8.625395e-01 | 0.064 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 8.630418e-01 | 0.064 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 8.634652e-01 | 0.064 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 8.634652e-01 | 0.064 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 8.634652e-01 | 0.064 | 0 | 0 |
| mRNA decay by 3' to 5' exoribonuclease | R-HSA-429958 | 8.634652e-01 | 0.064 | 0 | 0 |
| Erythrocytes take up carbon dioxide and release oxygen | R-HSA-1237044 | 8.634652e-01 | 0.064 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 8.634652e-01 | 0.064 | 0 | 0 |
| O2/CO2 exchange in erythrocytes | R-HSA-1480926 | 8.634652e-01 | 0.064 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 8.634652e-01 | 0.064 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 8.634652e-01 | 0.064 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 8.663678e-01 | 0.062 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 8.663678e-01 | 0.062 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 8.675239e-01 | 0.062 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 8.675239e-01 | 0.062 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 8.677972e-01 | 0.062 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 8.677972e-01 | 0.062 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 8.690885e-01 | 0.061 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 8.711562e-01 | 0.060 | 0 | 0 |
| Glycosphingolipid transport | R-HSA-9845576 | 8.711562e-01 | 0.060 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 8.711562e-01 | 0.060 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 8.711562e-01 | 0.060 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 8.727688e-01 | 0.059 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 8.727688e-01 | 0.059 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 8.736349e-01 | 0.059 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 8.736349e-01 | 0.059 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 8.743438e-01 | 0.058 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 8.743438e-01 | 0.058 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 8.743438e-01 | 0.058 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 8.747466e-01 | 0.058 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 8.747466e-01 | 0.058 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 8.792732e-01 | 0.056 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 8.801141e-01 | 0.055 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 8.805497e-01 | 0.055 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 8.841029e-01 | 0.053 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 8.843563e-01 | 0.053 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 8.843563e-01 | 0.053 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 8.843563e-01 | 0.053 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 8.843563e-01 | 0.053 | 0 | 0 |
| Abacavir metabolism | R-HSA-2161541 | 8.843563e-01 | 0.053 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 8.843563e-01 | 0.053 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 8.864129e-01 | 0.052 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 8.869154e-01 | 0.052 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 8.869154e-01 | 0.052 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 8.869154e-01 | 0.052 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 8.920573e-01 | 0.050 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 8.933762e-01 | 0.049 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 8.935715e-01 | 0.049 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 8.935715e-01 | 0.049 | 0 | 0 |
| Ribavirin ADME | R-HSA-9755088 | 8.935715e-01 | 0.049 | 0 | 0 |
| Molybdenum cofactor biosynthesis | R-HSA-947581 | 8.935715e-01 | 0.049 | 0 | 0 |
| Glutathione synthesis and recycling | R-HSA-174403 | 8.935715e-01 | 0.049 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 8.935715e-01 | 0.049 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 8.941069e-01 | 0.049 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 8.941069e-01 | 0.049 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 8.941069e-01 | 0.049 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 8.941069e-01 | 0.049 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 8.961946e-01 | 0.048 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 8.964753e-01 | 0.047 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 8.964753e-01 | 0.047 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 8.999231e-01 | 0.046 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 9.008710e-01 | 0.045 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 9.008710e-01 | 0.045 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.008710e-01 | 0.045 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 9.013609e-01 | 0.045 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 9.020528e-01 | 0.045 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 9.020528e-01 | 0.045 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 9.020528e-01 | 0.045 | 0 | 0 |
| Cholesterol biosynthesis via lathosterol | R-HSA-6807062 | 9.020528e-01 | 0.045 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 9.020528e-01 | 0.045 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 9.020528e-01 | 0.045 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 9.020528e-01 | 0.045 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 9.049524e-01 | 0.043 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 9.072301e-01 | 0.042 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 9.076495e-01 | 0.042 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 9.098588e-01 | 0.041 | 0 | 0 |
| Free fatty acids regulate insulin secretion | R-HSA-400451 | 9.098588e-01 | 0.041 | 0 | 0 |
| Mitochondrial mRNA modification | R-HSA-9937008 | 9.098588e-01 | 0.041 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 9.098588e-01 | 0.041 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 9.132058e-01 | 0.039 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 9.132058e-01 | 0.039 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 9.132058e-01 | 0.039 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 9.138662e-01 | 0.039 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 9.153837e-01 | 0.038 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 9.165247e-01 | 0.038 | 1 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 9.170431e-01 | 0.038 | 0 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 9.170431e-01 | 0.038 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 9.170431e-01 | 0.038 | 0 | 0 |
| Mitochondrial RNA degradation | R-HSA-9836573 | 9.170431e-01 | 0.038 | 0 | 0 |
| Complex III assembly | R-HSA-9865881 | 9.170431e-01 | 0.038 | 0 | 0 |
| TNFs bind their physiological receptors | R-HSA-5669034 | 9.170431e-01 | 0.038 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 9.170431e-01 | 0.038 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 9.188187e-01 | 0.037 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 9.188187e-01 | 0.037 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 9.193033e-01 | 0.037 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 9.211854e-01 | 0.036 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 9.236552e-01 | 0.034 | 0 | 0 |
| Beta-oxidation of pristanoyl-CoA | R-HSA-389887 | 9.236552e-01 | 0.034 | 0 | 0 |
| MicroRNA (miRNA) biogenesis | R-HSA-203927 | 9.236552e-01 | 0.034 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 9.236552e-01 | 0.034 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 9.236552e-01 | 0.034 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 9.236552e-01 | 0.034 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 9.236552e-01 | 0.034 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 9.240888e-01 | 0.034 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 9.247540e-01 | 0.034 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.286328e-01 | 0.032 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 9.290349e-01 | 0.032 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 9.290349e-01 | 0.032 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 9.297406e-01 | 0.032 | 0 | 0 |
| Abacavir ADME | R-HSA-2161522 | 9.297406e-01 | 0.032 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 9.297406e-01 | 0.032 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 9.336753e-01 | 0.030 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 9.336753e-01 | 0.030 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 9.336753e-01 | 0.030 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 9.336753e-01 | 0.030 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.347515e-01 | 0.029 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 9.353413e-01 | 0.029 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 9.353413e-01 | 0.029 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 9.353413e-01 | 0.029 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 9.353413e-01 | 0.029 | 0 | 0 |
| Maturation of hRSV A proteins | R-HSA-9828806 | 9.353413e-01 | 0.029 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 9.360837e-01 | 0.029 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 9.380272e-01 | 0.028 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 9.380272e-01 | 0.028 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 9.380272e-01 | 0.028 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 9.404959e-01 | 0.027 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 9.404959e-01 | 0.027 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 9.404959e-01 | 0.027 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 9.404959e-01 | 0.027 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 9.404959e-01 | 0.027 | 0 | 0 |
| Iron assimilation using enterobactin | R-HSA-9638334 | 9.404959e-01 | 0.027 | 0 | 0 |
| Pyrimidine salvage | R-HSA-73614 | 9.404959e-01 | 0.027 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 9.404959e-01 | 0.027 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 9.438638e-01 | 0.025 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 9.438638e-01 | 0.025 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 9.438638e-01 | 0.025 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 9.452398e-01 | 0.024 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 9.452398e-01 | 0.024 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 9.464706e-01 | 0.024 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 9.468193e-01 | 0.024 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.495130e-01 | 0.022 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 9.496057e-01 | 0.022 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 9.496057e-01 | 0.022 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 9.496057e-01 | 0.022 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 9.496057e-01 | 0.022 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.496057e-01 | 0.022 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 9.505482e-01 | 0.022 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 9.517499e-01 | 0.021 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 9.520303e-01 | 0.021 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.526811e-01 | 0.021 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 9.531227e-01 | 0.021 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 9.536090e-01 | 0.021 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 9.536239e-01 | 0.021 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 9.536239e-01 | 0.021 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 9.536239e-01 | 0.021 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 9.536239e-01 | 0.021 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 9.536239e-01 | 0.021 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 9.546466e-01 | 0.020 | 0 | 0 |
| Branched-chain amino acid catabolism | R-HSA-70895 | 9.560093e-01 | 0.020 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 9.560093e-01 | 0.020 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 9.562390e-01 | 0.019 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 9.573218e-01 | 0.019 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 9.573218e-01 | 0.019 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 9.588488e-01 | 0.018 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 9.589496e-01 | 0.018 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 9.589496e-01 | 0.018 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 9.593214e-01 | 0.018 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 9.604756e-01 | 0.018 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 9.607251e-01 | 0.017 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 9.607251e-01 | 0.017 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 9.607251e-01 | 0.017 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 9.607251e-01 | 0.017 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.613119e-01 | 0.017 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.635902e-01 | 0.016 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 9.635902e-01 | 0.016 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 9.638572e-01 | 0.016 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 9.638572e-01 | 0.016 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 9.638572e-01 | 0.016 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 9.638572e-01 | 0.016 | 0 | 0 |
| Heme degradation | R-HSA-189483 | 9.638572e-01 | 0.016 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 9.642747e-01 | 0.016 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 9.658282e-01 | 0.015 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 9.666817e-01 | 0.015 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 9.666817e-01 | 0.015 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 9.667397e-01 | 0.015 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 9.667397e-01 | 0.015 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 9.667397e-01 | 0.015 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 9.667397e-01 | 0.015 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 9.689323e-01 | 0.014 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 9.689323e-01 | 0.014 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 9.693352e-01 | 0.014 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 9.693925e-01 | 0.014 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 9.693925e-01 | 0.014 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 9.693925e-01 | 0.014 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 9.693925e-01 | 0.014 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 9.693925e-01 | 0.014 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 9.694698e-01 | 0.013 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.710360e-01 | 0.013 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 9.718338e-01 | 0.012 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 9.718338e-01 | 0.012 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 9.718338e-01 | 0.012 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 9.719237e-01 | 0.012 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.726824e-01 | 0.012 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 9.734100e-01 | 0.012 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.734100e-01 | 0.012 | 0 | 0 |
| Voltage gated Potassium channels | R-HSA-1296072 | 9.740805e-01 | 0.011 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 9.740805e-01 | 0.011 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 9.740805e-01 | 0.011 | 0 | 0 |
| Beta-oxidation of very long chain fatty acids | R-HSA-390247 | 9.740805e-01 | 0.011 | 0 | 0 |
| NCAM1 interactions | R-HSA-419037 | 9.740805e-01 | 0.011 | 0 | 0 |
| Collagen chain trimerization | R-HSA-8948216 | 9.740805e-01 | 0.011 | 0 | 0 |
| Metabolism of folate and pterines | R-HSA-196757 | 9.740805e-01 | 0.011 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 9.742246e-01 | 0.011 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.744245e-01 | 0.011 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 9.748387e-01 | 0.011 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.748387e-01 | 0.011 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 9.748655e-01 | 0.011 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 9.748655e-01 | 0.011 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 9.748655e-01 | 0.011 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 9.761482e-01 | 0.010 | 0 | 0 |
| tRNA processing in the mitochondrion | R-HSA-6785470 | 9.761482e-01 | 0.010 | 0 | 0 |
| Depurination | R-HSA-73927 | 9.761482e-01 | 0.010 | 0 | 0 |
| alpha-linolenic acid (ALA) metabolism | R-HSA-2046106 | 9.761482e-01 | 0.010 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 9.761482e-01 | 0.010 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 9.769910e-01 | 0.010 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 9.780510e-01 | 0.010 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 9.780510e-01 | 0.010 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 9.780510e-01 | 0.010 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.781566e-01 | 0.010 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.796525e-01 | 0.009 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 9.798021e-01 | 0.009 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 9.798021e-01 | 0.009 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 9.798021e-01 | 0.009 | 0 | 0 |
| rRNA processing in the mitochondrion | R-HSA-8868766 | 9.798021e-01 | 0.009 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 9.798021e-01 | 0.009 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.812423e-01 | 0.008 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 9.814136e-01 | 0.008 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 9.814136e-01 | 0.008 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 9.814136e-01 | 0.008 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 9.814136e-01 | 0.008 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 9.814136e-01 | 0.008 | 0 | 0 |
| Aflatoxin activation and detoxification | R-HSA-5423646 | 9.814136e-01 | 0.008 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 9.818900e-01 | 0.008 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 9.828966e-01 | 0.007 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 9.828966e-01 | 0.007 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 9.829363e-01 | 0.007 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 9.840681e-01 | 0.007 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 9.842614e-01 | 0.007 | 0 | 0 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 9.842614e-01 | 0.007 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.847025e-01 | 0.007 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 9.855173e-01 | 0.006 | 0 | 0 |
| Defensins | R-HSA-1461973 | 9.855173e-01 | 0.006 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 9.855173e-01 | 0.006 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 9.855173e-01 | 0.006 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 9.857422e-01 | 0.006 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.857606e-01 | 0.006 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.857606e-01 | 0.006 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 9.859873e-01 | 0.006 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 9.866731e-01 | 0.006 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 9.866731e-01 | 0.006 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 9.866731e-01 | 0.006 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 9.866731e-01 | 0.006 | 0 | 0 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | R-HSA-2142691 | 9.866731e-01 | 0.006 | 0 | 0 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | R-HSA-196741 | 9.866731e-01 | 0.006 | 0 | 0 |
| O-linked glycosylation of mucins | R-HSA-913709 | 9.867473e-01 | 0.006 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 9.867473e-01 | 0.006 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 9.869153e-01 | 0.006 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 9.877368e-01 | 0.005 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 9.877368e-01 | 0.005 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 9.877368e-01 | 0.005 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 9.884828e-01 | 0.005 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 9.887155e-01 | 0.005 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 9.887155e-01 | 0.005 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 9.893243e-01 | 0.005 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.893243e-01 | 0.005 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.893243e-01 | 0.005 | 0 | 0 |
| Metal ion assimilation from the host | R-HSA-9638482 | 9.893243e-01 | 0.005 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 9.894691e-01 | 0.005 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 9.894691e-01 | 0.005 | 0 | 0 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | R-HSA-2046104 | 9.896163e-01 | 0.005 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 9.901965e-01 | 0.004 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 9.904451e-01 | 0.004 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 9.904451e-01 | 0.004 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 9.905441e-01 | 0.004 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 9.912079e-01 | 0.004 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 9.913232e-01 | 0.004 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 9.919098e-01 | 0.004 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 9.919573e-01 | 0.004 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 9.925557e-01 | 0.003 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 9.925557e-01 | 0.003 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 9.931501e-01 | 0.003 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 9.932136e-01 | 0.003 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.935817e-01 | 0.003 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 9.940629e-01 | 0.003 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 9.942003e-01 | 0.003 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 9.943254e-01 | 0.002 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 9.943254e-01 | 0.002 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 9.944558e-01 | 0.002 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 9.944558e-01 | 0.002 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.946701e-01 | 0.002 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 9.948479e-01 | 0.002 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 9.950897e-01 | 0.002 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 9.952106e-01 | 0.002 | 1 | 1 |
| Protein localization | R-HSA-9609507 | 9.952505e-01 | 0.002 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 9.954642e-01 | 0.002 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 9.955524e-01 | 0.002 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.958427e-01 | 0.002 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 9.959610e-01 | 0.002 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 9.959610e-01 | 0.002 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 9.961506e-01 | 0.002 | 0 | 0 |
| Sialic acid metabolism | R-HSA-4085001 | 9.961748e-01 | 0.002 | 0 | 0 |
| Glutathione conjugation | R-HSA-156590 | 9.964804e-01 | 0.002 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.964804e-01 | 0.002 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.966893e-01 | 0.001 | 0 | 0 |
| Nucleotide salvage | R-HSA-8956321 | 9.967615e-01 | 0.001 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 9.969256e-01 | 0.001 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 9.970203e-01 | 0.001 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 9.970203e-01 | 0.001 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 9.971807e-01 | 0.001 | 0 | 0 |
| Complex I biogenesis | R-HSA-6799198 | 9.972583e-01 | 0.001 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 9.972583e-01 | 0.001 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 9.973494e-01 | 0.001 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 9.973495e-01 | 0.001 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.975393e-01 | 0.001 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.977048e-01 | 0.001 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 9.977157e-01 | 0.001 | 0 | 0 |
| Protein folding | R-HSA-391251 | 9.980320e-01 | 0.001 | 0 | 0 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | R-HSA-193368 | 9.980351e-01 | 0.001 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.981921e-01 | 0.001 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 9.982383e-01 | 0.001 | 1 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 9.982580e-01 | 0.001 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.982966e-01 | 0.001 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.984230e-01 | 0.001 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 9.984272e-01 | 0.001 | 0 | 0 |
| Glycosphingolipid catabolism | R-HSA-9840310 | 9.984696e-01 | 0.001 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 9.985407e-01 | 0.001 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 9.985407e-01 | 0.001 | 0 | 0 |
| Metabolism of porphyrins | R-HSA-189445 | 9.985919e-01 | 0.001 | 0 | 0 |
| Purine catabolism | R-HSA-74259 | 9.987045e-01 | 0.001 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.988080e-01 | 0.001 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.989033e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.989192e-01 | 0.000 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 9.989532e-01 | 0.000 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 9.989910e-01 | 0.000 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 9.990599e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.991657e-01 | 0.000 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 9.992142e-01 | 0.000 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 9.992576e-01 | 0.000 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.992771e-01 | 0.000 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.992835e-01 | 0.000 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.993329e-01 | 0.000 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.993791e-01 | 0.000 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 9.994092e-01 | 0.000 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 9.994475e-01 | 0.000 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 9.994475e-01 | 0.000 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 9.994523e-01 | 0.000 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.994754e-01 | 0.000 | 0 | 0 |
| Peroxisomal lipid metabolism | R-HSA-390918 | 9.995235e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.995639e-01 | 0.000 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.996010e-01 | 0.000 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 9.996058e-01 | 0.000 | 1 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 9.996254e-01 | 0.000 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 9.996254e-01 | 0.000 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.996254e-01 | 0.000 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 9.996860e-01 | 0.000 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 9.997203e-01 | 0.000 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 9.997442e-01 | 0.000 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 9.997751e-01 | 0.000 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 9.997931e-01 | 0.000 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 9.998096e-01 | 0.000 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.998096e-01 | 0.000 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.998249e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.998263e-01 | 0.000 | 0 | 0 |
| Mitochondrial Fatty Acid Beta-Oxidation | R-HSA-77289 | 9.998389e-01 | 0.000 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 9.998518e-01 | 0.000 | 0 | 0 |
| Scavenging of heme from plasma | R-HSA-2168880 | 9.998518e-01 | 0.000 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.998637e-01 | 0.000 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 9.998637e-01 | 0.000 | 0 | 0 |
| Immune System | R-HSA-168256 | 9.998674e-01 | 0.000 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 9.998951e-01 | 0.000 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.999093e-01 | 0.000 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 9.999102e-01 | 0.000 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 9.999240e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.999627e-01 | 0.000 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 9.999659e-01 | 0.000 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.999783e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.999842e-01 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 9.999851e-01 | 0.000 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.999869e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid metabolism | R-HSA-1660662 | 9.999889e-01 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 9.999906e-01 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 9.999910e-01 | 0.000 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.999920e-01 | 0.000 | 0 | 0 |
| Nucleotide catabolism | R-HSA-8956319 | 9.999938e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999944e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.999948e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.999948e-01 | 0.000 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 9.999951e-01 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 9.999952e-01 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 9.999964e-01 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 9.999985e-01 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 9.999987e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.999988e-01 | 0.000 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 9.999989e-01 | 0.000 | 0 | 0 |
| Translation | R-HSA-72766 | 9.999989e-01 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 9.999992e-01 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 9.999992e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999992e-01 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 9.999993e-01 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 9.999995e-01 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 9.999995e-01 | 0.000 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 9.999996e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.999998e-01 | 0.000 | 0 | 0 |
| Infection with Enterobacteria | R-HSA-9640148 | 9.999998e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.999998e-01 | 0.000 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.999999e-01 | 0.000 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.999999e-01 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 9.999999e-01 | 0.000 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 1.000000e+00 | 0.000 | 0 | 0 |
| Disease | R-HSA-1643685 | 1.000000e+00 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 1.000000e+00 | 0.000 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 1.000000e+00 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Cellular response to heat stress | R-HSA-3371556 | 5.551115e-15 | 14.256 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 1.709743e-14 | 13.767 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 9.728884e-13 | 12.012 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 7.596257e-12 | 11.119 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 3.261669e-11 | 10.487 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 4.533340e-11 | 10.344 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 2.118540e-10 | 9.674 | 1 | 0 |
| Cell Cycle | R-HSA-1640170 | 6.505951e-10 | 9.187 | 1 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 3.883313e-08 | 7.411 | 0 | 0 |
| M Phase | R-HSA-68886 | 4.487983e-08 | 7.348 | 1 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 6.781551e-08 | 7.169 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 8.903936e-08 | 7.050 | 1 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 1.049185e-07 | 6.979 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 1.184777e-07 | 6.926 | 1 | 0 |
| mRNA Splicing | R-HSA-72172 | 1.564603e-07 | 6.806 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 1.849267e-07 | 6.733 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 2.161384e-07 | 6.665 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 2.629528e-07 | 6.580 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 2.577469e-07 | 6.589 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 2.950603e-07 | 6.530 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 3.134330e-07 | 6.504 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 1.810618e-06 | 5.742 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 1.975339e-06 | 5.704 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 1.975339e-06 | 5.704 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 2.731621e-06 | 5.564 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 2.835392e-06 | 5.547 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 3.783942e-06 | 5.422 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 4.171954e-06 | 5.380 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 4.204972e-06 | 5.376 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 4.599039e-06 | 5.337 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 5.393898e-06 | 5.268 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 6.898898e-06 | 5.161 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 1.421464e-05 | 4.847 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 1.856459e-05 | 4.731 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 1.994767e-05 | 4.700 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 2.851111e-05 | 4.545 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 3.463935e-05 | 4.460 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 4.990480e-05 | 4.302 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 5.410353e-05 | 4.267 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 7.083388e-05 | 4.150 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 6.917897e-05 | 4.160 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 8.435986e-05 | 4.074 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 8.435986e-05 | 4.074 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 8.399884e-05 | 4.076 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 9.232602e-05 | 4.035 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 9.386500e-05 | 4.027 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 9.443213e-05 | 4.025 | 1 | 0 |
| Apoptosis | R-HSA-109581 | 9.037288e-05 | 4.044 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 9.841573e-05 | 4.007 | 1 | 1 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 1.133419e-04 | 3.946 | 1 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 1.133419e-04 | 3.946 | 1 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 1.417998e-04 | 3.848 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 1.518625e-04 | 3.819 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 1.524141e-04 | 3.817 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 1.738910e-04 | 3.760 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 1.883474e-04 | 3.725 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 2.102307e-04 | 3.677 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 2.309838e-04 | 3.636 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 2.309838e-04 | 3.636 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 2.365261e-04 | 3.626 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 2.495308e-04 | 3.603 | 0 | 0 |
| Kinesins | R-HSA-983189 | 2.846288e-04 | 3.546 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 2.852155e-04 | 3.545 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 2.973496e-04 | 3.527 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 3.313271e-04 | 3.480 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 3.331001e-04 | 3.477 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 3.247931e-04 | 3.488 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 3.414431e-04 | 3.467 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 3.773067e-04 | 3.423 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 3.835687e-04 | 3.416 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 3.835687e-04 | 3.416 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 3.714793e-04 | 3.430 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 3.998800e-04 | 3.398 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 4.421609e-04 | 3.354 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 4.270165e-04 | 3.370 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 4.805995e-04 | 3.318 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 6.485328e-04 | 3.188 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 6.677906e-04 | 3.175 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 6.679047e-04 | 3.175 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 6.833057e-04 | 3.165 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 7.169007e-04 | 3.145 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 7.531552e-04 | 3.123 | 1 | 1 |
| Membrane Trafficking | R-HSA-199991 | 8.091396e-04 | 3.092 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 8.280510e-04 | 3.082 | 0 | 0 |
| Loss of MECP2 binding ability to 5mC-DNA | R-HSA-9022538 | 9.188762e-04 | 3.037 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 9.258303e-04 | 3.033 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 9.288803e-04 | 3.032 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 1.018698e-03 | 2.992 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 1.336997e-03 | 2.874 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 1.451645e-03 | 2.838 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 1.490037e-03 | 2.827 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 1.508107e-03 | 2.822 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 1.602353e-03 | 2.795 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 1.850101e-03 | 2.733 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 2.238274e-03 | 2.650 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 2.422276e-03 | 2.616 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 2.451695e-03 | 2.611 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 2.510821e-03 | 2.600 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 2.802958e-03 | 2.552 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 2.895624e-03 | 2.538 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 2.909823e-03 | 2.536 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 2.926677e-03 | 2.534 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 3.116006e-03 | 2.506 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 3.116006e-03 | 2.506 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 3.258893e-03 | 2.487 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 3.417226e-03 | 2.466 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 3.246450e-03 | 2.489 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 3.246450e-03 | 2.489 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 3.417226e-03 | 2.466 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 3.311369e-03 | 2.480 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 3.255259e-03 | 2.487 | 1 | 0 |
| Influenza Infection | R-HSA-168255 | 3.424944e-03 | 2.465 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 3.555244e-03 | 2.449 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 3.565746e-03 | 2.448 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 3.700225e-03 | 2.432 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 4.048192e-03 | 2.393 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 3.827328e-03 | 2.417 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 4.067054e-03 | 2.391 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 3.829317e-03 | 2.417 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 4.233480e-03 | 2.373 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 4.582034e-03 | 2.339 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 4.719823e-03 | 2.326 | 1 | 1 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 4.945839e-03 | 2.306 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 4.945839e-03 | 2.306 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 5.147092e-03 | 2.288 | 1 | 1 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 5.208899e-03 | 2.283 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 5.304809e-03 | 2.275 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 5.351178e-03 | 2.272 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 5.758473e-03 | 2.240 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 5.758473e-03 | 2.240 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 6.008888e-03 | 2.221 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 6.315966e-03 | 2.200 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 6.374223e-03 | 2.196 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 6.458397e-03 | 2.190 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 7.002350e-03 | 2.155 | 1 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 7.172126e-03 | 2.144 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 7.212859e-03 | 2.142 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 7.307730e-03 | 2.136 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 7.405176e-03 | 2.130 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 8.160198e-03 | 2.088 | 1 | 1 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 8.160198e-03 | 2.088 | 1 | 1 |
| Gene expression (Transcription) | R-HSA-74160 | 8.075223e-03 | 2.093 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 7.596856e-03 | 2.119 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 8.354955e-03 | 2.078 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 8.470130e-03 | 2.072 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 8.480935e-03 | 2.072 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 8.905999e-03 | 2.050 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 8.976549e-03 | 2.047 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 8.980161e-03 | 2.047 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 8.980161e-03 | 2.047 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperone genes | R-HSA-381183 | 9.307719e-03 | 2.031 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 9.335413e-03 | 2.030 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 9.547240e-03 | 2.020 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 9.972852e-03 | 2.001 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 1.053730e-02 | 1.977 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 1.060049e-02 | 1.975 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 1.201639e-02 | 1.920 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 1.201639e-02 | 1.920 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 1.201639e-02 | 1.920 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 1.086516e-02 | 1.964 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 1.201802e-02 | 1.920 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 1.206516e-02 | 1.918 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 1.257265e-02 | 1.901 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 1.257265e-02 | 1.901 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 1.257265e-02 | 1.901 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 1.257265e-02 | 1.901 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 1.257265e-02 | 1.901 | 0 | 0 |
| Loss of MECP2 binding ability to 5hmC-DNA | R-HSA-9022534 | 1.257265e-02 | 1.901 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 1.257762e-02 | 1.900 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 1.257762e-02 | 1.900 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 1.265540e-02 | 1.898 | 1 | 1 |
| ATF6 (ATF6-alpha) activates chaperones | R-HSA-381033 | 1.521525e-02 | 1.818 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 1.521525e-02 | 1.818 | 0 | 0 |
| Protein folding | R-HSA-391251 | 1.425514e-02 | 1.846 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 1.403922e-02 | 1.853 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 1.521525e-02 | 1.818 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 1.377202e-02 | 1.861 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 1.510229e-02 | 1.821 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 1.454643e-02 | 1.837 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 1.390950e-02 | 1.857 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 1.454979e-02 | 1.837 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 1.403922e-02 | 1.853 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 1.451978e-02 | 1.838 | 0 | 0 |
| S Phase | R-HSA-69242 | 1.524493e-02 | 1.817 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 1.569459e-02 | 1.804 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 1.569459e-02 | 1.804 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 1.649994e-02 | 1.783 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 1.691648e-02 | 1.772 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 1.703075e-02 | 1.769 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 1.723680e-02 | 1.764 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 1.723680e-02 | 1.764 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 1.723680e-02 | 1.764 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 1.755085e-02 | 1.756 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 1.755085e-02 | 1.756 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 1.755085e-02 | 1.756 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 1.755085e-02 | 1.756 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 1.789183e-02 | 1.747 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 1.931361e-02 | 1.714 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 1.893790e-02 | 1.723 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 1.870825e-02 | 1.728 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 2.134349e-02 | 1.671 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 2.134349e-02 | 1.671 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 1.983483e-02 | 1.703 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 1.955168e-02 | 1.709 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 1.870825e-02 | 1.728 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 1.947161e-02 | 1.711 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 1.934290e-02 | 1.713 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 1.870825e-02 | 1.728 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 2.086869e-02 | 1.681 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 1.870825e-02 | 1.728 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 1.931361e-02 | 1.714 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 1.870825e-02 | 1.728 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 2.158977e-02 | 1.666 | 1 | 1 |
| IRS activation | R-HSA-74713 | 2.180650e-02 | 1.661 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 2.294596e-02 | 1.639 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 2.321387e-02 | 1.634 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 2.321387e-02 | 1.634 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 2.321387e-02 | 1.634 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 2.321387e-02 | 1.634 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 2.352502e-02 | 1.628 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 2.423106e-02 | 1.616 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 2.445554e-02 | 1.612 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 2.494359e-02 | 1.603 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 2.494359e-02 | 1.603 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 2.494359e-02 | 1.603 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 2.558588e-02 | 1.592 | 1 | 0 |
| Manipulation of host energy metabolism | R-HSA-9636667 | 2.677925e-02 | 1.572 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 2.738162e-02 | 1.563 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 2.824622e-02 | 1.549 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 2.846442e-02 | 1.546 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 2.950091e-02 | 1.530 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 3.014451e-02 | 1.521 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 3.063413e-02 | 1.514 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 3.063413e-02 | 1.514 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 3.080517e-02 | 1.511 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 3.115935e-02 | 1.506 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 3.246428e-02 | 1.489 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 3.425659e-02 | 1.465 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 3.872484e-02 | 1.412 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 3.872484e-02 | 1.412 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 3.872484e-02 | 1.412 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 3.451097e-02 | 1.462 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 3.585958e-02 | 1.445 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 3.585958e-02 | 1.445 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 3.772313e-02 | 1.423 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 3.743991e-02 | 1.427 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 3.850744e-02 | 1.414 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 3.265871e-02 | 1.486 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 3.533650e-02 | 1.452 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 3.772313e-02 | 1.423 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 3.872484e-02 | 1.412 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 3.867812e-02 | 1.413 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 3.859856e-02 | 1.413 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 3.652011e-02 | 1.437 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 3.886281e-02 | 1.410 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 3.959013e-02 | 1.402 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 3.959013e-02 | 1.402 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 4.079094e-02 | 1.389 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 4.106129e-02 | 1.387 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 4.125072e-02 | 1.385 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 4.125072e-02 | 1.385 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 4.173461e-02 | 1.380 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 4.287754e-02 | 1.368 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 4.332388e-02 | 1.363 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 4.508565e-02 | 1.346 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 4.508565e-02 | 1.346 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 4.508565e-02 | 1.346 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 4.508565e-02 | 1.346 | 0 | 0 |
| TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 4.508565e-02 | 1.346 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 4.508565e-02 | 1.346 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 4.508565e-02 | 1.346 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 4.508565e-02 | 1.346 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 4.508565e-02 | 1.346 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 4.508565e-02 | 1.346 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 4.508565e-02 | 1.346 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 4.508565e-02 | 1.346 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 4.508565e-02 | 1.346 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 5.303978e-02 | 1.275 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 5.303978e-02 | 1.275 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 5.303978e-02 | 1.275 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 5.303978e-02 | 1.275 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 4.628445e-02 | 1.335 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 4.628445e-02 | 1.335 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 5.517157e-02 | 1.258 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 4.876445e-02 | 1.312 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 5.434945e-02 | 1.265 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 5.427185e-02 | 1.265 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 5.513716e-02 | 1.259 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 5.120921e-02 | 1.291 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 5.044898e-02 | 1.297 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 5.231207e-02 | 1.281 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 5.479898e-02 | 1.261 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 4.754451e-02 | 1.323 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 5.288861e-02 | 1.277 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 5.523771e-02 | 1.258 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 4.878598e-02 | 1.312 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 5.231207e-02 | 1.281 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 4.628445e-02 | 1.335 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 4.740181e-02 | 1.324 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 4.876445e-02 | 1.312 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 4.904888e-02 | 1.309 | 1 | 0 |
| Signal Transduction | R-HSA-162582 | 4.974006e-02 | 1.303 | 1 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 5.303978e-02 | 1.275 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 5.651161e-02 | 1.248 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 5.434945e-02 | 1.265 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 5.453809e-02 | 1.263 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 4.876445e-02 | 1.312 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 5.161050e-02 | 1.287 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 5.685725e-02 | 1.245 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 5.822673e-02 | 1.235 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 6.031779e-02 | 1.220 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 6.153309e-02 | 1.211 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 6.157207e-02 | 1.211 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 6.157207e-02 | 1.211 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 6.203811e-02 | 1.207 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 6.203811e-02 | 1.207 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 6.308225e-02 | 1.200 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 6.445556e-02 | 1.191 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 6.649746e-02 | 1.177 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 6.649746e-02 | 1.177 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 6.667602e-02 | 1.176 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 6.674154e-02 | 1.176 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 6.674154e-02 | 1.176 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 6.762950e-02 | 1.170 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 6.885739e-02 | 1.162 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 6.894855e-02 | 1.161 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 7.016457e-02 | 1.154 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 7.016457e-02 | 1.154 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 7.016457e-02 | 1.154 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 7.172988e-02 | 1.144 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 7.314262e-02 | 1.136 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 7.341497e-02 | 1.134 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 7.341497e-02 | 1.134 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 7.341497e-02 | 1.134 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 7.593020e-02 | 1.120 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 7.643612e-02 | 1.117 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 7.674262e-02 | 1.115 | 0 | 0 |
| Loss of function of TP53 in cancer due to loss of tetramerization ability | R-HSA-9723905 | 8.041970e-02 | 1.095 | 0 | 0 |
| Loss of Function of TP53 in Cancer | R-HSA-9723907 | 8.041970e-02 | 1.095 | 0 | 0 |
| MECP2 regulates transcription of genes involved in GABA signaling | R-HSA-9022927 | 9.109060e-02 | 1.041 | 0 | 0 |
| RUNX2 regulates genes involved in differentiation of myeloid cells | R-HSA-8941333 | 9.109060e-02 | 1.041 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 9.109060e-02 | 1.041 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 8.134415e-02 | 1.090 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 8.961531e-02 | 1.048 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 8.961531e-02 | 1.048 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 8.961531e-02 | 1.048 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 1.023262e-01 | 0.990 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 7.938185e-02 | 1.100 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 7.938185e-02 | 1.100 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 7.938185e-02 | 1.100 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 8.165166e-02 | 1.088 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 8.848857e-02 | 1.053 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 8.848857e-02 | 1.053 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 8.762960e-02 | 1.057 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 8.829618e-02 | 1.054 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 8.552446e-02 | 1.068 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 1.007169e-01 | 0.997 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 8.921312e-02 | 1.050 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 9.747654e-02 | 1.011 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 8.921312e-02 | 1.050 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 9.596068e-02 | 1.018 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 8.134415e-02 | 1.090 | 0 | 0 |
| Translation | R-HSA-72766 | 1.021405e-01 | 0.991 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 1.023262e-01 | 0.990 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 8.054516e-02 | 1.094 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 9.529722e-02 | 1.021 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 9.747654e-02 | 1.011 | 0 | 0 |
| MTF1 activates gene expression | R-HSA-5660489 | 9.109060e-02 | 1.041 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 8.134415e-02 | 1.090 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 8.134415e-02 | 1.090 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 7.938185e-02 | 1.100 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 8.022759e-02 | 1.096 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 8.380657e-02 | 1.077 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 8.552446e-02 | 1.068 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 8.165166e-02 | 1.088 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 7.772016e-02 | 1.109 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 7.863187e-02 | 1.104 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 8.380657e-02 | 1.077 | 0 | 0 |
| p75NTR negatively regulates cell cycle via SC1 | R-HSA-193670 | 9.109060e-02 | 1.041 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 7.772016e-02 | 1.109 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 7.938185e-02 | 1.100 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 8.486554e-02 | 1.071 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 9.964388e-02 | 1.002 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 9.379045e-02 | 1.028 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 7.772016e-02 | 1.109 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 9.747654e-02 | 1.011 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 7.938185e-02 | 1.100 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 8.829618e-02 | 1.054 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 8.683611e-02 | 1.061 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 1.031256e-01 | 0.987 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 1.031256e-01 | 0.987 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 1.031256e-01 | 0.987 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 1.035471e-01 | 0.985 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 1.042383e-01 | 0.982 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 1.048545e-01 | 0.979 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 1.048545e-01 | 0.979 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 1.087280e-01 | 0.964 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 1.106563e-01 | 0.956 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 1.128166e-01 | 0.948 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 1.128885e-01 | 0.947 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 1.132440e-01 | 0.946 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 1.147823e-01 | 0.940 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 1.147823e-01 | 0.940 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 1.147823e-01 | 0.940 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 1.147823e-01 | 0.940 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 1.147823e-01 | 0.940 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 1.152469e-01 | 0.938 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 1.158121e-01 | 0.936 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 1.158121e-01 | 0.936 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 1.175603e-01 | 0.930 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 1.175603e-01 | 0.930 | 0 | 0 |
| RUNX2 regulates chondrocyte maturation | R-HSA-8941284 | 1.175603e-01 | 0.930 | 0 | 0 |
| Post-transcriptional silencing by small RNAs | R-HSA-426496 | 1.175603e-01 | 0.930 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 1.175603e-01 | 0.930 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 1.175603e-01 | 0.930 | 0 | 0 |
| Pyrophosphate hydrolysis | R-HSA-71737 | 1.175603e-01 | 0.930 | 0 | 0 |
| Nectin/Necl trans heterodimerization | R-HSA-420597 | 1.175603e-01 | 0.930 | 0 | 0 |
| Assembly of Viral Components at the Budding Site | R-HSA-168316 | 1.175603e-01 | 0.930 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 1.180298e-01 | 0.928 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 1.183002e-01 | 0.927 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 1.210333e-01 | 0.917 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 1.219038e-01 | 0.914 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 1.222293e-01 | 0.913 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 1.230055e-01 | 0.910 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 1.233826e-01 | 0.909 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 1.251669e-01 | 0.903 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 1.254803e-01 | 0.901 | 0 | 0 |
| Regulation of PAK-2p34 activity by PS-GAP/RHG10 | R-HSA-211728 | 1.543765e-01 | 0.811 | 0 | 0 |
| RPIA deficiency: failed conversion of R5P to RU5P | R-HSA-5659996 | 1.543765e-01 | 0.811 | 0 | 0 |
| RPIA deficiency: failed conversion of RU5P to R5P | R-HSA-6791461 | 1.543765e-01 | 0.811 | 0 | 0 |
| TICAM1 deficiency - HSE | R-HSA-5602566 | 1.543765e-01 | 0.811 | 0 | 0 |
| Defective DNA double strand break response due to BRCA1 loss of function | R-HSA-9663199 | 1.543765e-01 | 0.811 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | R-HSA-9645722 | 1.543765e-01 | 0.811 | 0 | 0 |
| Defective DNA double strand break response due to BARD1 loss of function | R-HSA-9699150 | 1.543765e-01 | 0.811 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH6 | R-HSA-5632968 | 1.543765e-01 | 0.811 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 1.456526e-01 | 0.837 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 1.456526e-01 | 0.837 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 1.749359e-01 | 0.757 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 1.524400e-01 | 0.817 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 1.524400e-01 | 0.817 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 1.524400e-01 | 0.817 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 1.524400e-01 | 0.817 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 1.300275e-01 | 0.886 | 0 | 0 |
| Regulation of PD-L1(CD274) translation | R-HSA-9909620 | 1.604470e-01 | 0.795 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 1.343393e-01 | 0.872 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 1.765448e-01 | 0.753 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 1.469602e-01 | 0.833 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 1.339490e-01 | 0.873 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 1.312758e-01 | 0.882 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 1.563018e-01 | 0.806 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 1.361474e-01 | 0.866 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 1.361474e-01 | 0.866 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 1.614280e-01 | 0.792 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 1.614280e-01 | 0.792 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 1.451507e-01 | 0.838 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 1.451507e-01 | 0.838 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 1.451507e-01 | 0.838 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 1.831050e-01 | 0.737 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 1.831050e-01 | 0.737 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 1.640019e-01 | 0.785 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 1.405320e-01 | 0.852 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 1.738313e-01 | 0.760 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 1.409030e-01 | 0.851 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 1.873777e-01 | 0.727 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 1.563018e-01 | 0.806 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 1.408163e-01 | 0.851 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 1.875965e-01 | 0.727 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 1.604470e-01 | 0.795 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 1.831050e-01 | 0.737 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 1.736195e-01 | 0.760 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 1.614280e-01 | 0.792 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 1.390248e-01 | 0.857 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 1.510493e-01 | 0.821 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 1.908890e-01 | 0.719 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 1.933555e-01 | 0.714 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 1.908890e-01 | 0.719 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 1.931606e-01 | 0.714 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 1.749359e-01 | 0.757 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 1.680526e-01 | 0.775 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 1.933555e-01 | 0.714 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 1.312758e-01 | 0.882 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 1.887061e-01 | 0.724 | 1 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 1.564782e-01 | 0.806 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 1.638575e-01 | 0.786 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 1.717200e-01 | 0.765 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 1.456526e-01 | 0.837 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 1.749359e-01 | 0.757 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 1.749590e-01 | 0.757 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 1.624096e-01 | 0.789 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 1.725505e-01 | 0.763 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 1.300275e-01 | 0.886 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 1.875965e-01 | 0.727 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 1.308857e-01 | 0.883 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 1.544385e-01 | 0.811 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 1.291220e-01 | 0.889 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 1.390248e-01 | 0.857 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 1.691251e-01 | 0.772 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 1.456526e-01 | 0.837 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 1.933555e-01 | 0.714 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 1.749590e-01 | 0.757 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 1.933068e-01 | 0.714 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 1.477923e-01 | 0.830 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 1.560566e-01 | 0.807 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 1.738313e-01 | 0.760 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 1.510493e-01 | 0.821 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 1.933555e-01 | 0.714 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 1.738313e-01 | 0.760 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 1.361474e-01 | 0.866 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 1.647747e-01 | 0.783 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 1.449232e-01 | 0.839 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 1.749359e-01 | 0.757 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 1.801607e-01 | 0.744 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 1.901432e-01 | 0.721 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 2.016390e-01 | 0.695 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 2.019618e-01 | 0.695 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 2.050373e-01 | 0.688 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 2.050373e-01 | 0.688 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 2.050373e-01 | 0.688 | 0 | 0 |
| Cation-coupled Chloride cotransporters | R-HSA-426117 | 2.050373e-01 | 0.688 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 2.053651e-01 | 0.687 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 2.053651e-01 | 0.687 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 2.055029e-01 | 0.687 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 2.059121e-01 | 0.686 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 2.059121e-01 | 0.686 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 2.099538e-01 | 0.678 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 2.102381e-01 | 0.677 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 2.102381e-01 | 0.677 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 2.131335e-01 | 0.671 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 2.147388e-01 | 0.668 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 2.147388e-01 | 0.668 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 2.147388e-01 | 0.668 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 2.166819e-01 | 0.664 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 2.184135e-01 | 0.661 | 0 | 0 |
| Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | R-HSA-5619111 | 2.223894e-01 | 0.653 | 0 | 0 |
| Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) | R-HSA-5619039 | 2.223894e-01 | 0.653 | 0 | 0 |
| Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) | R-HSA-5619050 | 2.223894e-01 | 0.653 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 2.223894e-01 | 0.653 | 0 | 0 |
| TRAF3 deficiency - HSE | R-HSA-5602571 | 2.223894e-01 | 0.653 | 0 | 0 |
| Defective SLC6A2 causes orthostatic intolerance (OI) | R-HSA-5619109 | 2.223894e-01 | 0.653 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH2 | R-HSA-5632928 | 2.223894e-01 | 0.653 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 2.223894e-01 | 0.653 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 2.228283e-01 | 0.652 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 2.228283e-01 | 0.652 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 2.265940e-01 | 0.645 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 2.317396e-01 | 0.635 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 2.350446e-01 | 0.629 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 2.356361e-01 | 0.628 | 0 | 0 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 2.356361e-01 | 0.628 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 2.356361e-01 | 0.628 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 2.356361e-01 | 0.628 | 0 | 0 |
| Regulation of NPAS4 mRNA translation | R-HSA-9768778 | 2.356361e-01 | 0.628 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 2.356361e-01 | 0.628 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 2.356361e-01 | 0.628 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 2.356361e-01 | 0.628 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 2.365879e-01 | 0.626 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 2.365879e-01 | 0.626 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 2.365879e-01 | 0.626 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 2.849358e-01 | 0.545 | 0 | 0 |
| RUNX3 regulates RUNX1-mediated transcription | R-HSA-8951911 | 2.849358e-01 | 0.545 | 0 | 0 |
| Glycogen storage disease type XV (GYG1) | R-HSA-3814836 | 2.849358e-01 | 0.545 | 0 | 0 |
| Glycogen storage disease type 0 (muscle GYS1) | R-HSA-3828062 | 2.849358e-01 | 0.545 | 0 | 0 |
| TGFBR2 Kinase Domain Mutants in Cancer | R-HSA-3645790 | 2.849358e-01 | 0.545 | 0 | 0 |
| Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | R-HSA-5619089 | 2.849358e-01 | 0.545 | 0 | 0 |
| PLC-gamma1 signalling | R-HSA-167021 | 3.424547e-01 | 0.465 | 0 | 0 |
| Activated NTRK3 signals through PLCG1 | R-HSA-9034793 | 3.424547e-01 | 0.465 | 0 | 0 |
| Adrenaline signalling through Alpha-2 adrenergic receptor | R-HSA-392023 | 3.424547e-01 | 0.465 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 3.424547e-01 | 0.465 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 2.664579e-01 | 0.574 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 2.664579e-01 | 0.574 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 2.664579e-01 | 0.574 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 2.664579e-01 | 0.574 | 1 | 1 |
| 5-Phosphoribose 1-diphosphate biosynthesis | R-HSA-73843 | 2.664579e-01 | 0.574 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 3.953501e-01 | 0.403 | 0 | 0 |
| Activated NTRK2 signals through PLCG1 | R-HSA-9026527 | 3.953501e-01 | 0.403 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 3.953501e-01 | 0.403 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 3.953501e-01 | 0.403 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 3.953501e-01 | 0.403 | 0 | 0 |
| Defective LFNG causes SCDO3 | R-HSA-5083630 | 3.953501e-01 | 0.403 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 3.953501e-01 | 0.403 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 2.972691e-01 | 0.527 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 2.972691e-01 | 0.527 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 2.972691e-01 | 0.527 | 0 | 0 |
| Antigen processing: Ub, ATP-independent proteasomal degradation | R-HSA-9912633 | 2.587957e-01 | 0.587 | 0 | 0 |
| Regulation of CDH11 mRNA translation by microRNAs | R-HSA-9759811 | 3.278723e-01 | 0.484 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 4.439932e-01 | 0.353 | 0 | 0 |
| Enhanced binding of GP1BA variant to VWF multimer:collagen | R-HSA-9845620 | 4.439932e-01 | 0.353 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 4.439932e-01 | 0.353 | 0 | 0 |
| Defective binding of VWF variant to GPIb:IX:V | R-HSA-9846298 | 4.439932e-01 | 0.353 | 0 | 0 |
| Defective F9 activation | R-HSA-9673221 | 4.439932e-01 | 0.353 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 4.439932e-01 | 0.353 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 2.455507e-01 | 0.610 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 3.581017e-01 | 0.446 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 3.265868e-01 | 0.486 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 3.878195e-01 | 0.411 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 3.878195e-01 | 0.411 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 3.878195e-01 | 0.411 | 1 | 1 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 3.005800e-01 | 0.522 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 2.784231e-01 | 0.555 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 4.169126e-01 | 0.380 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 2.419670e-01 | 0.616 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 3.380217e-01 | 0.471 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 3.380217e-01 | 0.471 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 3.015706e-01 | 0.521 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 3.430975e-01 | 0.465 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 3.430975e-01 | 0.465 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 4.165670e-01 | 0.380 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 2.785836e-01 | 0.555 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 3.943536e-01 | 0.404 | 0 | 0 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | R-HSA-8948700 | 4.728764e-01 | 0.325 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 4.728764e-01 | 0.325 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 2.704356e-01 | 0.568 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 3.328117e-01 | 0.478 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 3.590759e-01 | 0.445 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 4.315276e-01 | 0.365 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 4.498889e-01 | 0.347 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 3.615536e-01 | 0.442 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 2.927707e-01 | 0.533 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 2.976138e-01 | 0.526 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 4.498889e-01 | 0.347 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 2.872545e-01 | 0.542 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 2.872545e-01 | 0.542 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 2.820345e-01 | 0.550 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 3.594763e-01 | 0.444 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 4.130043e-01 | 0.384 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 2.587957e-01 | 0.587 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 3.581017e-01 | 0.446 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 3.673254e-01 | 0.435 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 3.581017e-01 | 0.446 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 3.492769e-01 | 0.457 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 3.758772e-01 | 0.425 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 2.872545e-01 | 0.542 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 2.972691e-01 | 0.527 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 3.038873e-01 | 0.517 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 2.972691e-01 | 0.527 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 3.038873e-01 | 0.517 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 2.784231e-01 | 0.555 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 4.498889e-01 | 0.347 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 2.491639e-01 | 0.604 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 3.953501e-01 | 0.403 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 3.328117e-01 | 0.478 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 4.165670e-01 | 0.380 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 2.482514e-01 | 0.605 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 3.718819e-01 | 0.430 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 4.564293e-01 | 0.341 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 4.725593e-01 | 0.326 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 3.430975e-01 | 0.465 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 2.760933e-01 | 0.559 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 4.411365e-01 | 0.355 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 2.784231e-01 | 0.555 | 0 | 0 |
| Resolution of AP sites via the single-nucleotide replacement pathway | R-HSA-110381 | 4.439932e-01 | 0.353 | 0 | 0 |
| Activation of AKT2 | R-HSA-165158 | 4.439932e-01 | 0.353 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 3.265868e-01 | 0.486 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 3.758772e-01 | 0.425 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 3.758772e-01 | 0.425 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 4.130043e-01 | 0.384 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 3.922709e-01 | 0.406 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 4.498889e-01 | 0.347 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 4.572355e-01 | 0.340 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 3.160140e-01 | 0.500 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 2.784231e-01 | 0.555 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 3.193492e-01 | 0.496 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 4.814378e-01 | 0.317 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 4.399036e-01 | 0.357 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 4.802038e-01 | 0.319 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 3.040006e-01 | 0.517 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 3.067463e-01 | 0.513 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 4.227607e-01 | 0.374 | 1 | 0 |
| Transcriptional activation of p53 responsive genes | R-HSA-69560 | 3.953501e-01 | 0.403 | 0 | 0 |
| Transcriptional activation of cell cycle inhibitor p21 | R-HSA-69895 | 3.953501e-01 | 0.403 | 0 | 0 |
| Toxicity of botulinum toxin type G (botG) | R-HSA-5250989 | 4.439932e-01 | 0.353 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 2.820345e-01 | 0.550 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 4.165670e-01 | 0.380 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 3.943536e-01 | 0.404 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 3.323041e-01 | 0.478 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 2.802146e-01 | 0.553 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 3.725347e-01 | 0.429 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 2.455507e-01 | 0.610 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 2.455507e-01 | 0.610 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 2.748968e-01 | 0.561 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 4.249265e-01 | 0.372 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 3.305612e-01 | 0.481 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 4.498889e-01 | 0.347 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 3.358217e-01 | 0.474 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 3.492769e-01 | 0.457 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 4.455572e-01 | 0.351 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 4.707620e-01 | 0.327 | 1 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 2.983639e-01 | 0.525 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 2.608693e-01 | 0.584 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 3.001110e-01 | 0.523 | 0 | 0 |
| Loss of Function of TGFBR2 in Cancer | R-HSA-3642278 | 2.849358e-01 | 0.545 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 2.849358e-01 | 0.545 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 3.424547e-01 | 0.465 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 2.664579e-01 | 0.574 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 3.953501e-01 | 0.403 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 3.953501e-01 | 0.403 | 0 | 0 |
| vRNP Assembly | R-HSA-192905 | 3.278723e-01 | 0.484 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 3.878195e-01 | 0.411 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 2.419670e-01 | 0.616 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 4.728764e-01 | 0.325 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 4.728764e-01 | 0.325 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 4.601668e-01 | 0.337 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 4.498889e-01 | 0.347 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 4.130043e-01 | 0.384 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 4.572355e-01 | 0.340 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 3.001110e-01 | 0.523 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 3.893337e-01 | 0.410 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 3.719906e-01 | 0.429 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 3.718819e-01 | 0.430 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 4.728764e-01 | 0.325 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 3.878195e-01 | 0.411 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 4.227071e-01 | 0.374 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 2.664579e-01 | 0.574 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 2.664579e-01 | 0.574 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 4.452892e-01 | 0.351 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 3.210529e-01 | 0.493 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 3.158005e-01 | 0.501 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 3.685441e-01 | 0.434 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 3.454278e-01 | 0.462 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 2.664579e-01 | 0.574 | 0 | 0 |
| Activation of NOXA and translocation to mitochondria | R-HSA-111448 | 3.953501e-01 | 0.403 | 0 | 0 |
| Synthesis of PG | R-HSA-1483148 | 2.587957e-01 | 0.587 | 0 | 0 |
| Muscarinic acetylcholine receptors | R-HSA-390648 | 4.439932e-01 | 0.353 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 2.626278e-01 | 0.581 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 4.452892e-01 | 0.351 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 4.206842e-01 | 0.376 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 3.961334e-01 | 0.402 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 3.301716e-01 | 0.481 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 2.812606e-01 | 0.551 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 2.784231e-01 | 0.555 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 2.730895e-01 | 0.564 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 4.385284e-01 | 0.358 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 2.962413e-01 | 0.528 | 0 | 0 |
| Diseases of Mismatch Repair (MMR) | R-HSA-5423599 | 3.424547e-01 | 0.465 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 2.664579e-01 | 0.574 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 3.953501e-01 | 0.403 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 3.953501e-01 | 0.403 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 2.972691e-01 | 0.527 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 3.278723e-01 | 0.484 | 0 | 0 |
| Inositol transporters | R-HSA-429593 | 4.439932e-01 | 0.353 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 3.568212e-01 | 0.448 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 4.165670e-01 | 0.380 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 3.594763e-01 | 0.444 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 3.943536e-01 | 0.404 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 4.680562e-01 | 0.330 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 3.825446e-01 | 0.417 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 4.572355e-01 | 0.340 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 3.095857e-01 | 0.509 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 4.498889e-01 | 0.347 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 3.492769e-01 | 0.457 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 3.718819e-01 | 0.430 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 4.814378e-01 | 0.317 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 2.944011e-01 | 0.531 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 3.005800e-01 | 0.522 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 3.408116e-01 | 0.467 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 4.680562e-01 | 0.330 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 4.130043e-01 | 0.384 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 4.515804e-01 | 0.345 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 4.424038e-01 | 0.354 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 4.732011e-01 | 0.325 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 3.575848e-01 | 0.447 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 2.972691e-01 | 0.527 | 0 | 0 |
| Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | R-HSA-9931529 | 4.439932e-01 | 0.353 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 3.581017e-01 | 0.446 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 3.005800e-01 | 0.522 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 2.543304e-01 | 0.595 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 2.580698e-01 | 0.588 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 4.798384e-01 | 0.319 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 2.587957e-01 | 0.587 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 4.474745e-01 | 0.349 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 2.927707e-01 | 0.533 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 2.664579e-01 | 0.574 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 4.385284e-01 | 0.358 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 4.315276e-01 | 0.365 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 4.498889e-01 | 0.347 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 3.385270e-01 | 0.470 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 2.636737e-01 | 0.579 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 4.480172e-01 | 0.349 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 4.240685e-01 | 0.373 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 2.626278e-01 | 0.581 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 3.943328e-01 | 0.404 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 2.590994e-01 | 0.587 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 4.452892e-01 | 0.351 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 4.732011e-01 | 0.325 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 3.581017e-01 | 0.446 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 4.532844e-01 | 0.344 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 3.878195e-01 | 0.411 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 2.927707e-01 | 0.533 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 4.034718e-01 | 0.394 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 3.718819e-01 | 0.430 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 3.155453e-01 | 0.501 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 2.972691e-01 | 0.527 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 3.785167e-01 | 0.422 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 4.860001e-01 | 0.313 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 4.887257e-01 | 0.311 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 4.887257e-01 | 0.311 | 0 | 0 |
| Signaling by Overexpressed Wild-Type EGFR in Cancer | R-HSA-5638302 | 4.887257e-01 | 0.311 | 0 | 0 |
| Inhibition of Signaling by Overexpressed EGFR | R-HSA-5638303 | 4.887257e-01 | 0.311 | 0 | 0 |
| Toxicity of botulinum toxin type E (botE) | R-HSA-5250992 | 4.887257e-01 | 0.311 | 0 | 0 |
| Pentose phosphate pathway disease | R-HSA-6791465 | 4.887257e-01 | 0.311 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 4.887257e-01 | 0.311 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 4.887257e-01 | 0.311 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 4.887257e-01 | 0.311 | 0 | 0 |
| Defects of platelet adhesion to exposed collagen | R-HSA-9823587 | 4.887257e-01 | 0.311 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 4.887257e-01 | 0.311 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 4.887257e-01 | 0.311 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 4.929857e-01 | 0.307 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 4.996176e-01 | 0.301 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 4.996176e-01 | 0.301 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 4.996176e-01 | 0.301 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 4.996176e-01 | 0.301 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 4.996176e-01 | 0.301 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 4.996176e-01 | 0.301 | 0 | 0 |
| Virus Assembly and Release | R-HSA-168268 | 4.996176e-01 | 0.301 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 5.023026e-01 | 0.299 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 5.036940e-01 | 0.298 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 5.036940e-01 | 0.298 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 5.036940e-01 | 0.298 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 5.046490e-01 | 0.297 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 5.060300e-01 | 0.296 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 5.075505e-01 | 0.295 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 5.075505e-01 | 0.295 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 5.079817e-01 | 0.294 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 5.094922e-01 | 0.293 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 5.186470e-01 | 0.285 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 5.200934e-01 | 0.284 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 5.200934e-01 | 0.284 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 5.211136e-01 | 0.283 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 5.211136e-01 | 0.283 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 5.227277e-01 | 0.282 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 5.227277e-01 | 0.282 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 5.227277e-01 | 0.282 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 5.253231e-01 | 0.280 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 5.254704e-01 | 0.279 | 1 | 1 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 5.254704e-01 | 0.279 | 0 | 0 |
| Response to metal ions | R-HSA-5660526 | 5.254704e-01 | 0.279 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 5.298619e-01 | 0.276 | 0 | 0 |
| Small interfering RNA (siRNA) biogenesis | R-HSA-426486 | 5.298619e-01 | 0.276 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 5.298619e-01 | 0.276 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 5.298619e-01 | 0.276 | 0 | 0 |
| Autointegration results in viral DNA circles | R-HSA-177539 | 5.298619e-01 | 0.276 | 0 | 0 |
| Defective CHST14 causes EDS, musculocontractural type | R-HSA-3595174 | 5.298619e-01 | 0.276 | 0 | 0 |
| Defective CHST3 causes SEDCJD | R-HSA-3595172 | 5.298619e-01 | 0.276 | 0 | 0 |
| Toxicity of botulinum toxin type F (botF) | R-HSA-5250981 | 5.298619e-01 | 0.276 | 0 | 0 |
| Toxicity of botulinum toxin type D (botD) | R-HSA-5250955 | 5.298619e-01 | 0.276 | 0 | 0 |
| Integration of viral DNA into host genomic DNA | R-HSA-175567 | 5.298619e-01 | 0.276 | 0 | 0 |
| Leukotriene receptors | R-HSA-391906 | 5.298619e-01 | 0.276 | 0 | 0 |
| HDL clearance | R-HSA-8964011 | 5.298619e-01 | 0.276 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 5.332796e-01 | 0.273 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 5.353286e-01 | 0.271 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 5.382370e-01 | 0.269 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 5.382370e-01 | 0.269 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 5.382370e-01 | 0.269 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 5.426843e-01 | 0.265 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 5.426843e-01 | 0.265 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 5.426843e-01 | 0.265 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 5.426843e-01 | 0.265 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 5.503391e-01 | 0.259 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 5.503391e-01 | 0.259 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 5.504046e-01 | 0.259 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 5.504046e-01 | 0.259 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 5.504046e-01 | 0.259 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 5.504046e-01 | 0.259 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 5.527142e-01 | 0.257 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 5.550448e-01 | 0.256 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 5.550448e-01 | 0.256 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 5.621484e-01 | 0.250 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 5.621484e-01 | 0.250 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 5.621484e-01 | 0.250 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 5.621484e-01 | 0.250 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 5.628930e-01 | 0.250 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 5.651109e-01 | 0.248 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 5.657805e-01 | 0.247 | 0 | 0 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | 5.676905e-01 | 0.246 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 5.676905e-01 | 0.246 | 0 | 0 |
| Defective CHSY1 causes TPBS | R-HSA-3595177 | 5.676905e-01 | 0.246 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 5.676905e-01 | 0.246 | 0 | 0 |
| Pre-NOTCH Processing in the Endoplasmic Reticulum | R-HSA-1912399 | 5.676905e-01 | 0.246 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 5.676905e-01 | 0.246 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 5.676905e-01 | 0.246 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 5.676905e-01 | 0.246 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 5.676905e-01 | 0.246 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 5.676905e-01 | 0.246 | 0 | 0 |
| TGFBR3 regulates TGF-beta signaling | R-HSA-9839389 | 5.676905e-01 | 0.246 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 5.676905e-01 | 0.246 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 5.715199e-01 | 0.243 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 5.744007e-01 | 0.241 | 0 | 0 |
| PKA activation | R-HSA-163615 | 5.744007e-01 | 0.241 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 5.744007e-01 | 0.241 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 5.744007e-01 | 0.241 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 5.744007e-01 | 0.241 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 5.744007e-01 | 0.241 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 5.744007e-01 | 0.241 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 5.796313e-01 | 0.237 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 5.805902e-01 | 0.236 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 5.811001e-01 | 0.236 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 5.811001e-01 | 0.236 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 5.811001e-01 | 0.236 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 5.811001e-01 | 0.236 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 5.844647e-01 | 0.233 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 5.876472e-01 | 0.231 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 5.876472e-01 | 0.231 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 5.876472e-01 | 0.231 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 5.876472e-01 | 0.231 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 5.876472e-01 | 0.231 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 5.876472e-01 | 0.231 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 5.903832e-01 | 0.229 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 5.911293e-01 | 0.228 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 5.935670e-01 | 0.227 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 5.938889e-01 | 0.226 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 5.974483e-01 | 0.224 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 5.974483e-01 | 0.224 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 5.974483e-01 | 0.224 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 5.974483e-01 | 0.224 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 5.974483e-01 | 0.224 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 5.974483e-01 | 0.224 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 5.974483e-01 | 0.224 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 5.974483e-01 | 0.224 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 5.974483e-01 | 0.224 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 5.980415e-01 | 0.223 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 5.995236e-01 | 0.222 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 5.997462e-01 | 0.222 | 0 | 0 |
| phospho-PLA2 pathway | R-HSA-111995 | 6.024774e-01 | 0.220 | 0 | 0 |
| MET receptor recycling | R-HSA-8875656 | 6.024774e-01 | 0.220 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 6.024774e-01 | 0.220 | 0 | 0 |
| Activated NTRK2 signals through PI3K | R-HSA-9028335 | 6.024774e-01 | 0.220 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 6.024774e-01 | 0.220 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 6.024774e-01 | 0.220 | 0 | 0 |
| Toxicity of botulinum toxin type B (botB) | R-HSA-5250958 | 6.024774e-01 | 0.220 | 0 | 0 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | 6.024774e-01 | 0.220 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 6.024774e-01 | 0.220 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 6.024774e-01 | 0.220 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 6.024774e-01 | 0.220 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 6.034141e-01 | 0.219 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 6.054247e-01 | 0.218 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 6.055344e-01 | 0.218 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 6.170979e-01 | 0.210 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 6.173182e-01 | 0.209 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 6.174065e-01 | 0.209 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 6.188095e-01 | 0.208 | 0 | 0 |
| Formation of ATP by chemiosmotic coupling | R-HSA-163210 | 6.195445e-01 | 0.208 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 6.195445e-01 | 0.208 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 6.215765e-01 | 0.207 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 6.215765e-01 | 0.207 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 6.254313e-01 | 0.204 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 6.254313e-01 | 0.204 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 6.254313e-01 | 0.204 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 6.254313e-01 | 0.204 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 6.260607e-01 | 0.203 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 6.338244e-01 | 0.198 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 6.338244e-01 | 0.198 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 6.344670e-01 | 0.198 | 0 | 0 |
| Toxicity of botulinum toxin type A (botA) | R-HSA-5250968 | 6.344670e-01 | 0.198 | 0 | 0 |
| APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | R-HSA-5649702 | 6.344670e-01 | 0.198 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 6.344670e-01 | 0.198 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 6.344670e-01 | 0.198 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 6.344670e-01 | 0.198 | 0 | 0 |
| Regulation of NPAS4 gene transcription | R-HSA-9768777 | 6.344670e-01 | 0.198 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 6.344670e-01 | 0.198 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 6.347400e-01 | 0.197 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 6.347400e-01 | 0.197 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 6.347400e-01 | 0.197 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 6.349899e-01 | 0.197 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 6.406934e-01 | 0.193 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 6.406934e-01 | 0.193 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 6.406934e-01 | 0.193 | 0 | 0 |
| Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 6.406934e-01 | 0.193 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 6.406934e-01 | 0.193 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 6.484516e-01 | 0.188 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 6.484516e-01 | 0.188 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 6.515182e-01 | 0.186 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 6.554762e-01 | 0.183 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 6.578516e-01 | 0.182 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 6.589894e-01 | 0.181 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 6.609041e-01 | 0.180 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 6.609041e-01 | 0.180 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 6.609041e-01 | 0.180 | 0 | 0 |
| Serine metabolism | R-HSA-977347 | 6.609041e-01 | 0.180 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 6.609229e-01 | 0.180 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 6.626856e-01 | 0.179 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 6.626856e-01 | 0.179 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 6.638841e-01 | 0.178 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 6.638841e-01 | 0.178 | 0 | 0 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | R-HSA-5140745 | 6.638841e-01 | 0.178 | 0 | 0 |
| Ion influx/efflux at host-pathogen interface | R-HSA-6803544 | 6.638841e-01 | 0.178 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 6.638841e-01 | 0.178 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 6.638841e-01 | 0.178 | 0 | 0 |
| Defective factor IX causes hemophilia B | R-HSA-9668250 | 6.638841e-01 | 0.178 | 0 | 0 |
| Interleukin-27 signaling | R-HSA-9020956 | 6.638841e-01 | 0.178 | 0 | 0 |
| Maturation of spike protein | R-HSA-9683686 | 6.638841e-01 | 0.178 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 6.675490e-01 | 0.176 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 6.677380e-01 | 0.175 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 6.677380e-01 | 0.175 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 6.723718e-01 | 0.172 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 6.725082e-01 | 0.172 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 6.734326e-01 | 0.172 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 6.744319e-01 | 0.171 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 6.749444e-01 | 0.171 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 6.749444e-01 | 0.171 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 6.801908e-01 | 0.167 | 0 | 0 |
| Neurotoxicity of clostridium toxins | R-HSA-168799 | 6.801908e-01 | 0.167 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 6.801908e-01 | 0.167 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 6.832139e-01 | 0.165 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 6.833987e-01 | 0.165 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 6.855155e-01 | 0.164 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 6.856328e-01 | 0.164 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 6.856328e-01 | 0.164 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 6.909354e-01 | 0.161 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 6.909354e-01 | 0.161 | 0 | 0 |
| SARS-CoV-2 modulates autophagy | R-HSA-9754560 | 6.909354e-01 | 0.161 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 6.909354e-01 | 0.161 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 6.909354e-01 | 0.161 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 6.909354e-01 | 0.161 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 6.939533e-01 | 0.159 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 6.945922e-01 | 0.158 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 6.975210e-01 | 0.156 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 6.982734e-01 | 0.156 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 6.985021e-01 | 0.156 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 6.985021e-01 | 0.156 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 6.985021e-01 | 0.156 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 6.985021e-01 | 0.156 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 6.985021e-01 | 0.156 | 0 | 0 |
| Regulation of PTEN mRNA translation | R-HSA-8943723 | 6.985711e-01 | 0.156 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 6.985711e-01 | 0.156 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 6.985711e-01 | 0.156 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 6.985711e-01 | 0.156 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 6.985711e-01 | 0.156 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 7.029950e-01 | 0.153 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 7.052149e-01 | 0.152 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 7.053185e-01 | 0.152 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 7.108195e-01 | 0.148 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 7.130517e-01 | 0.147 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 7.130547e-01 | 0.147 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 7.143810e-01 | 0.146 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 7.156298e-01 | 0.145 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 7.156298e-01 | 0.145 | 0 | 0 |
| DS-GAG biosynthesis | R-HSA-2022923 | 7.158110e-01 | 0.145 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 7.158110e-01 | 0.145 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 7.158110e-01 | 0.145 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 7.158110e-01 | 0.145 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 7.158110e-01 | 0.145 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 7.158110e-01 | 0.145 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 7.158110e-01 | 0.145 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 7.158110e-01 | 0.145 | 0 | 0 |
| Viral RNP Complexes in the Host Cell Nucleus | R-HSA-168330 | 7.158110e-01 | 0.145 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 7.158110e-01 | 0.145 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 7.158110e-01 | 0.145 | 0 | 0 |
| Complex III assembly | R-HSA-9865881 | 7.160662e-01 | 0.145 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 7.160662e-01 | 0.145 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 7.160662e-01 | 0.145 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 7.203554e-01 | 0.142 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 7.203554e-01 | 0.142 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 7.206060e-01 | 0.142 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 7.206060e-01 | 0.142 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 7.278647e-01 | 0.138 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 7.313007e-01 | 0.136 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 7.326992e-01 | 0.135 | 0 | 0 |
| MicroRNA (miRNA) biogenesis | R-HSA-203927 | 7.326992e-01 | 0.135 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 7.326992e-01 | 0.135 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 7.326992e-01 | 0.135 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 7.386858e-01 | 0.132 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 7.386858e-01 | 0.132 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 7.386858e-01 | 0.132 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 7.386858e-01 | 0.132 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 7.386858e-01 | 0.132 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 7.386858e-01 | 0.132 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 7.386858e-01 | 0.132 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 7.386858e-01 | 0.132 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 7.386858e-01 | 0.132 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 7.386858e-01 | 0.132 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 7.386858e-01 | 0.132 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 7.386858e-01 | 0.132 | 0 | 0 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 7.386858e-01 | 0.132 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 7.386858e-01 | 0.132 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 7.386858e-01 | 0.132 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 7.386858e-01 | 0.132 | 0 | 0 |
| Erythrocytes take up oxygen and release carbon dioxide | R-HSA-1247673 | 7.386858e-01 | 0.132 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 7.386858e-01 | 0.132 | 0 | 0 |
| Interleukin-35 Signalling | R-HSA-8984722 | 7.386858e-01 | 0.132 | 0 | 0 |
| Reversal of alkylation damage by DNA dioxygenases | R-HSA-73943 | 7.386858e-01 | 0.132 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 7.397019e-01 | 0.131 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 7.405128e-01 | 0.130 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 7.484957e-01 | 0.126 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 7.484957e-01 | 0.126 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 7.484957e-01 | 0.126 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 7.484957e-01 | 0.126 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 7.522506e-01 | 0.124 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 7.534398e-01 | 0.123 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 7.534398e-01 | 0.123 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 7.534398e-01 | 0.123 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 7.546693e-01 | 0.122 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 7.597207e-01 | 0.119 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 7.597207e-01 | 0.119 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 7.597207e-01 | 0.119 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 7.597207e-01 | 0.119 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 7.597207e-01 | 0.119 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 7.597207e-01 | 0.119 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 7.597207e-01 | 0.119 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 7.597207e-01 | 0.119 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 7.597207e-01 | 0.119 | 0 | 0 |
| Replication of the SARS-CoV-1 genome | R-HSA-9682706 | 7.597207e-01 | 0.119 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 7.620198e-01 | 0.118 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 7.630294e-01 | 0.117 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 7.634825e-01 | 0.117 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 7.634825e-01 | 0.117 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 7.634825e-01 | 0.117 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 7.634825e-01 | 0.117 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 7.634825e-01 | 0.117 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 7.634825e-01 | 0.117 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 7.634825e-01 | 0.117 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 7.658432e-01 | 0.116 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 7.658432e-01 | 0.116 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 7.658432e-01 | 0.116 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 7.658432e-01 | 0.116 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 7.675373e-01 | 0.115 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 7.730500e-01 | 0.112 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 7.739468e-01 | 0.111 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 7.776876e-01 | 0.109 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 7.776876e-01 | 0.109 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 7.776876e-01 | 0.109 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 7.776876e-01 | 0.109 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 7.776876e-01 | 0.109 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 7.776876e-01 | 0.109 | 0 | 0 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 7.777339e-01 | 0.109 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 7.777339e-01 | 0.109 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 7.777339e-01 | 0.109 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 7.790634e-01 | 0.108 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 7.790634e-01 | 0.108 | 0 | 0 |
| Retrograde neurotrophin signalling | R-HSA-177504 | 7.790634e-01 | 0.108 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 7.790634e-01 | 0.108 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 7.790634e-01 | 0.108 | 0 | 0 |
| Hydrolysis of LPC | R-HSA-1483115 | 7.790634e-01 | 0.108 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 7.790634e-01 | 0.108 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 7.790634e-01 | 0.108 | 0 | 0 |
| Acyl chain remodeling of CL | R-HSA-1482798 | 7.790634e-01 | 0.108 | 0 | 0 |
| SARS-CoV-1 Genome Replication and Transcription | R-HSA-9679514 | 7.790634e-01 | 0.108 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 7.813523e-01 | 0.107 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 7.813523e-01 | 0.107 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 7.821824e-01 | 0.107 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 7.834640e-01 | 0.106 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 7.872567e-01 | 0.104 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 7.911396e-01 | 0.102 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 7.911396e-01 | 0.102 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 7.911396e-01 | 0.102 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 7.911396e-01 | 0.102 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 7.911396e-01 | 0.102 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 7.930624e-01 | 0.101 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 7.968501e-01 | 0.099 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 7.968501e-01 | 0.099 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 7.968501e-01 | 0.099 | 0 | 0 |
| Protein lipoylation | R-HSA-9857492 | 7.968501e-01 | 0.099 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 7.968501e-01 | 0.099 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 7.968501e-01 | 0.099 | 0 | 0 |
| RNA Polymerase III Chain Elongation | R-HSA-73780 | 7.968501e-01 | 0.099 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 7.968501e-01 | 0.099 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 7.968501e-01 | 0.099 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 7.968501e-01 | 0.099 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 7.968501e-01 | 0.099 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 7.968501e-01 | 0.099 | 0 | 0 |
| Lysosphingolipid and LPA receptors | R-HSA-419408 | 7.968501e-01 | 0.099 | 0 | 0 |
| p38MAPK events | R-HSA-171007 | 7.968501e-01 | 0.099 | 0 | 0 |
| DNA Damage Reversal | R-HSA-73942 | 7.968501e-01 | 0.099 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 7.979793e-01 | 0.098 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 7.983792e-01 | 0.098 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 8.000231e-01 | 0.097 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 8.006415e-01 | 0.097 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 8.006415e-01 | 0.097 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 8.026074e-01 | 0.095 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 8.026074e-01 | 0.095 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 8.038678e-01 | 0.095 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 8.038678e-01 | 0.095 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 8.038678e-01 | 0.095 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 8.038678e-01 | 0.095 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 8.104467e-01 | 0.091 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 8.117922e-01 | 0.091 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 8.132059e-01 | 0.090 | 0 | 0 |
| Defective GALNT3 causes HFTC | R-HSA-5083625 | 8.132059e-01 | 0.090 | 0 | 0 |
| Defective GALNT12 causes CRCS1 | R-HSA-5083636 | 8.132059e-01 | 0.090 | 0 | 0 |
| Entry of Influenza Virion into Host Cell via Endocytosis | R-HSA-168275 | 8.132059e-01 | 0.090 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 8.132059e-01 | 0.090 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 8.132059e-01 | 0.090 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 8.132059e-01 | 0.090 | 0 | 0 |
| Differentiation of T cells | R-HSA-9945266 | 8.132059e-01 | 0.090 | 0 | 0 |
| Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | R-HSA-9942503 | 8.132059e-01 | 0.090 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 8.132059e-01 | 0.090 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 8.132059e-01 | 0.090 | 0 | 0 |
| Attachment and Entry | R-HSA-9678110 | 8.132059e-01 | 0.090 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 8.159014e-01 | 0.088 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 8.159014e-01 | 0.088 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 8.159014e-01 | 0.088 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 8.159014e-01 | 0.088 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 8.201191e-01 | 0.086 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 8.204071e-01 | 0.086 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 8.204071e-01 | 0.086 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 8.204071e-01 | 0.086 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 8.206242e-01 | 0.086 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 8.206242e-01 | 0.086 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 8.206242e-01 | 0.086 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 8.206242e-01 | 0.086 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 8.206242e-01 | 0.086 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 8.206242e-01 | 0.086 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 8.206242e-01 | 0.086 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 8.209500e-01 | 0.086 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 8.238824e-01 | 0.084 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 8.238824e-01 | 0.084 | 0 | 0 |
| Glycine degradation | R-HSA-6783984 | 8.282457e-01 | 0.082 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 8.282457e-01 | 0.082 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 8.282457e-01 | 0.082 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 8.282457e-01 | 0.082 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 8.282457e-01 | 0.082 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 8.282457e-01 | 0.082 | 0 | 0 |
| Passive transport by Aquaporins | R-HSA-432047 | 8.282457e-01 | 0.082 | 0 | 0 |
| tRNA modification in the mitochondrion | R-HSA-6787450 | 8.282457e-01 | 0.082 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 8.282457e-01 | 0.082 | 0 | 0 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | R-HSA-9651496 | 8.282457e-01 | 0.082 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 8.355311e-01 | 0.078 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 8.372622e-01 | 0.077 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 8.372622e-01 | 0.077 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 8.418140e-01 | 0.075 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 8.420754e-01 | 0.075 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 8.420754e-01 | 0.075 | 0 | 0 |
| Defective C1GALT1C1 causes TNPS | R-HSA-5083632 | 8.420754e-01 | 0.075 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 8.420754e-01 | 0.075 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 8.420754e-01 | 0.075 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 8.420754e-01 | 0.075 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 8.420754e-01 | 0.075 | 0 | 0 |
| Replication of the SARS-CoV-2 genome | R-HSA-9694686 | 8.420754e-01 | 0.075 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 8.438475e-01 | 0.074 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 8.450848e-01 | 0.073 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 8.450848e-01 | 0.073 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 8.460196e-01 | 0.073 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 8.460196e-01 | 0.073 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 8.476467e-01 | 0.072 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 8.476467e-01 | 0.072 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 8.481266e-01 | 0.072 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 8.481266e-01 | 0.072 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 8.481266e-01 | 0.072 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 8.511063e-01 | 0.070 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 8.522281e-01 | 0.069 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 8.547923e-01 | 0.068 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 8.547923e-01 | 0.068 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 8.547923e-01 | 0.068 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 8.547923e-01 | 0.068 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 8.547923e-01 | 0.068 | 0 | 0 |
| Tie2 Signaling | R-HSA-210993 | 8.547923e-01 | 0.068 | 0 | 0 |
| Vitamin D (calciferol) metabolism | R-HSA-196791 | 8.547923e-01 | 0.068 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 8.547923e-01 | 0.068 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 8.556920e-01 | 0.068 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 8.567256e-01 | 0.067 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 8.576720e-01 | 0.067 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 8.576720e-01 | 0.067 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 8.576720e-01 | 0.067 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 8.576720e-01 | 0.067 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 8.576720e-01 | 0.067 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 8.594612e-01 | 0.066 | 0 | 0 |
| Pre-NOTCH Processing in Golgi | R-HSA-1912420 | 8.664859e-01 | 0.062 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 8.664859e-01 | 0.062 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 8.664859e-01 | 0.062 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 8.664859e-01 | 0.062 | 0 | 0 |
| mRNA decay by 3' to 5' exoribonuclease | R-HSA-429958 | 8.664859e-01 | 0.062 | 0 | 0 |
| O2/CO2 exchange in erythrocytes | R-HSA-1480926 | 8.664859e-01 | 0.062 | 0 | 0 |
| Diseases of hemostasis | R-HSA-9671793 | 8.664859e-01 | 0.062 | 0 | 0 |
| Erythrocytes take up carbon dioxide and release oxygen | R-HSA-1237044 | 8.664859e-01 | 0.062 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 8.664859e-01 | 0.062 | 0 | 0 |
| SARS-CoV-2 Genome Replication and Transcription | R-HSA-9694682 | 8.664859e-01 | 0.062 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 8.666658e-01 | 0.062 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 8.666658e-01 | 0.062 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 8.666658e-01 | 0.062 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 8.719061e-01 | 0.060 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 8.745444e-01 | 0.058 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 8.751349e-01 | 0.058 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 8.751349e-01 | 0.058 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 8.772384e-01 | 0.057 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 8.772384e-01 | 0.057 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 8.772384e-01 | 0.057 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 8.772384e-01 | 0.057 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 8.772384e-01 | 0.057 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 8.772384e-01 | 0.057 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 8.772384e-01 | 0.057 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 8.772384e-01 | 0.057 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 8.772384e-01 | 0.057 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 8.772384e-01 | 0.057 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 8.772384e-01 | 0.057 | 0 | 0 |
| Creatine metabolism | R-HSA-71288 | 8.772384e-01 | 0.057 | 0 | 0 |
| Acyl chain remodelling of PI | R-HSA-1482922 | 8.772384e-01 | 0.057 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 8.772384e-01 | 0.057 | 0 | 0 |
| Pregnenolone biosynthesis | R-HSA-196108 | 8.772384e-01 | 0.057 | 0 | 0 |
| Eicosanoid ligand-binding receptors | R-HSA-391903 | 8.772384e-01 | 0.057 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 8.777706e-01 | 0.057 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 8.795824e-01 | 0.056 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 8.871256e-01 | 0.052 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 8.871256e-01 | 0.052 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 8.871256e-01 | 0.052 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 8.871256e-01 | 0.052 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 8.871256e-01 | 0.052 | 0 | 0 |
| Acyl chain remodelling of PG | R-HSA-1482925 | 8.871256e-01 | 0.052 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 8.878352e-01 | 0.052 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 8.906026e-01 | 0.050 | 0 | 0 |
| CS-GAG biosynthesis | R-HSA-2022870 | 8.962170e-01 | 0.048 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 8.962170e-01 | 0.048 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 8.962170e-01 | 0.048 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 8.962170e-01 | 0.048 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 8.962170e-01 | 0.048 | 0 | 0 |
| Ribavirin ADME | R-HSA-9755088 | 8.962170e-01 | 0.048 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 8.976059e-01 | 0.047 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 8.976511e-01 | 0.047 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 8.979279e-01 | 0.047 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.021788e-01 | 0.045 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 9.033931e-01 | 0.044 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 9.033931e-01 | 0.044 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 9.042746e-01 | 0.044 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 9.042746e-01 | 0.044 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 9.042746e-01 | 0.044 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 9.042746e-01 | 0.044 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 9.042746e-01 | 0.044 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 9.042746e-01 | 0.044 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.042746e-01 | 0.044 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 9.045766e-01 | 0.044 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 9.045766e-01 | 0.044 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 9.066229e-01 | 0.043 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.088830e-01 | 0.041 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 9.104956e-01 | 0.041 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.104956e-01 | 0.041 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 9.105034e-01 | 0.041 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 9.120055e-01 | 0.040 | 0 | 0 |
| Termination of O-glycan biosynthesis | R-HSA-977068 | 9.122634e-01 | 0.040 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 9.122634e-01 | 0.040 | 0 | 0 |
| ABC transporters in lipid homeostasis | R-HSA-1369062 | 9.122634e-01 | 0.040 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.140884e-01 | 0.039 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 9.163360e-01 | 0.038 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.169382e-01 | 0.038 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 9.183350e-01 | 0.037 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 9.190217e-01 | 0.037 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 9.190217e-01 | 0.037 | 0 | 0 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 9.193313e-01 | 0.037 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 9.193313e-01 | 0.037 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 9.193313e-01 | 0.037 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 9.193313e-01 | 0.037 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 9.218169e-01 | 0.035 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 9.218169e-01 | 0.035 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 9.218169e-01 | 0.035 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 9.218169e-01 | 0.035 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 9.246423e-01 | 0.034 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 9.246423e-01 | 0.034 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 9.250993e-01 | 0.034 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 9.258303e-01 | 0.033 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 9.258303e-01 | 0.033 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 9.258303e-01 | 0.033 | 0 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 9.258303e-01 | 0.033 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 9.258303e-01 | 0.033 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 9.258303e-01 | 0.033 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 9.269581e-01 | 0.033 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 9.269581e-01 | 0.033 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 9.269581e-01 | 0.033 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 9.281200e-01 | 0.032 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 9.281200e-01 | 0.032 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 9.281636e-01 | 0.032 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 9.281636e-01 | 0.032 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 9.284926e-01 | 0.032 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 9.317788e-01 | 0.031 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 9.317788e-01 | 0.031 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.318060e-01 | 0.031 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 9.318060e-01 | 0.031 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 9.318060e-01 | 0.031 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 9.318060e-01 | 0.031 | 0 | 0 |
| Urea cycle | R-HSA-70635 | 9.318060e-01 | 0.031 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 9.318060e-01 | 0.031 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 9.318060e-01 | 0.031 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 9.323082e-01 | 0.030 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 9.323082e-01 | 0.030 | 0 | 0 |
| Immune System | R-HSA-168256 | 9.324716e-01 | 0.030 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 9.353782e-01 | 0.029 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 9.358513e-01 | 0.029 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 9.358940e-01 | 0.029 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 9.362704e-01 | 0.029 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 9.372300e-01 | 0.028 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 9.372300e-01 | 0.028 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 9.373006e-01 | 0.028 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 9.373006e-01 | 0.028 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 9.373006e-01 | 0.028 | 0 | 0 |
| ER Quality Control Compartment (ERQC) | R-HSA-901032 | 9.373006e-01 | 0.028 | 0 | 0 |
| Maturation of hRSV A proteins | R-HSA-9828806 | 9.373006e-01 | 0.028 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 9.388524e-01 | 0.027 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 9.405309e-01 | 0.027 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 9.405309e-01 | 0.027 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 9.405309e-01 | 0.027 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 9.405309e-01 | 0.027 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 9.423528e-01 | 0.026 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 9.423528e-01 | 0.026 | 0 | 0 |
| Iron assimilation using enterobactin | R-HSA-9638334 | 9.423528e-01 | 0.026 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 9.423528e-01 | 0.026 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 9.442334e-01 | 0.025 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 9.444962e-01 | 0.025 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 9.445951e-01 | 0.025 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 9.445951e-01 | 0.025 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 9.461522e-01 | 0.024 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.469067e-01 | 0.024 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 9.469982e-01 | 0.024 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 9.469982e-01 | 0.024 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 9.469982e-01 | 0.024 | 0 | 0 |
| Activation of Matrix Metalloproteinases | R-HSA-1592389 | 9.469982e-01 | 0.024 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 9.482089e-01 | 0.023 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 9.496428e-01 | 0.022 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 9.500619e-01 | 0.022 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 9.500619e-01 | 0.022 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 9.500619e-01 | 0.022 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 9.500619e-01 | 0.022 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 9.511511e-01 | 0.022 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 9.511511e-01 | 0.022 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 9.511511e-01 | 0.022 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.512695e-01 | 0.022 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 9.512695e-01 | 0.022 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.516840e-01 | 0.022 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 9.564674e-01 | 0.019 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 9.569120e-01 | 0.019 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.570164e-01 | 0.019 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 9.579773e-01 | 0.019 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 9.579773e-01 | 0.019 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 9.585305e-01 | 0.018 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 9.586563e-01 | 0.018 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 9.588078e-01 | 0.018 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 9.588078e-01 | 0.018 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 9.600865e-01 | 0.018 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 9.608217e-01 | 0.017 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 9.609973e-01 | 0.017 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 9.621280e-01 | 0.017 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 9.621280e-01 | 0.017 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 9.621280e-01 | 0.017 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 9.621280e-01 | 0.017 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 9.621280e-01 | 0.017 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 9.634807e-01 | 0.016 | 0 | 0 |
| CS/DS degradation | R-HSA-2024101 | 9.651807e-01 | 0.015 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 9.651807e-01 | 0.015 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 9.658238e-01 | 0.015 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 9.659659e-01 | 0.015 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.679876e-01 | 0.014 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 9.679876e-01 | 0.014 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 9.679876e-01 | 0.014 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 9.679876e-01 | 0.014 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 9.679876e-01 | 0.014 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 9.682879e-01 | 0.014 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 9.705683e-01 | 0.013 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 9.724972e-01 | 0.012 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 9.729411e-01 | 0.012 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 9.729411e-01 | 0.012 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 9.733314e-01 | 0.012 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.736671e-01 | 0.012 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 9.738861e-01 | 0.011 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.744727e-01 | 0.011 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 9.749831e-01 | 0.011 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 9.751228e-01 | 0.011 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 9.751228e-01 | 0.011 | 0 | 0 |
| NCAM1 interactions | R-HSA-419037 | 9.751228e-01 | 0.011 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.761389e-01 | 0.010 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 9.765373e-01 | 0.010 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 9.771286e-01 | 0.010 | 0 | 0 |
| Depurination | R-HSA-73927 | 9.771286e-01 | 0.010 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 9.771286e-01 | 0.010 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 9.789729e-01 | 0.009 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 9.793744e-01 | 0.009 | 0 | 0 |
| Tryptophan catabolism | R-HSA-71240 | 9.806685e-01 | 0.008 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 9.806685e-01 | 0.008 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 9.807753e-01 | 0.008 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 9.807753e-01 | 0.008 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 9.833404e-01 | 0.007 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 9.836609e-01 | 0.007 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 9.836609e-01 | 0.007 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 9.836609e-01 | 0.007 | 0 | 0 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 9.849787e-01 | 0.007 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 9.864937e-01 | 0.006 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 9.869402e-01 | 0.006 | 0 | 0 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | R-HSA-2142691 | 9.873043e-01 | 0.006 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 9.875353e-01 | 0.005 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 9.880574e-01 | 0.005 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 9.882759e-01 | 0.005 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.883284e-01 | 0.005 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 9.890249e-01 | 0.005 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.899867e-01 | 0.004 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.899867e-01 | 0.004 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.901357e-01 | 0.004 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.908854e-01 | 0.004 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 9.912319e-01 | 0.004 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 9.912319e-01 | 0.004 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.913524e-01 | 0.004 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.915928e-01 | 0.004 | 0 | 0 |
| Glyoxylate metabolism and glycine degradation | R-HSA-389661 | 9.916633e-01 | 0.004 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.923321e-01 | 0.003 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 9.923360e-01 | 0.003 | 0 | 0 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | R-HSA-2162123 | 9.923360e-01 | 0.003 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.929545e-01 | 0.003 | 0 | 0 |
| Cytosolic sulfonation of small molecules | R-HSA-156584 | 9.929545e-01 | 0.003 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.940187e-01 | 0.003 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.944457e-01 | 0.002 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.944814e-01 | 0.002 | 0 | 0 |
| Chondroitin sulfate/dermatan sulfate metabolism | R-HSA-1793185 | 9.949682e-01 | 0.002 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.957478e-01 | 0.002 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 9.958355e-01 | 0.002 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 9.959618e-01 | 0.002 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.962054e-01 | 0.002 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 9.964067e-01 | 0.002 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 9.966968e-01 | 0.001 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 9.968127e-01 | 0.001 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.969635e-01 | 0.001 | 0 | 0 |
| Complex I biogenesis | R-HSA-6799198 | 9.974342e-01 | 0.001 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.976244e-01 | 0.001 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.976311e-01 | 0.001 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.980530e-01 | 0.001 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 9.981492e-01 | 0.001 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.981492e-01 | 0.001 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.981680e-01 | 0.001 | 0 | 0 |
| Metabolism of steroid hormones | R-HSA-196071 | 9.981680e-01 | 0.001 | 0 | 0 |
| O-linked glycosylation of mucins | R-HSA-913709 | 9.983160e-01 | 0.001 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.983160e-01 | 0.001 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 9.983688e-01 | 0.001 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.983850e-01 | 0.001 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 9.985598e-01 | 0.001 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.985771e-01 | 0.001 | 0 | 0 |
| Glycosphingolipid catabolism | R-HSA-9840310 | 9.985771e-01 | 0.001 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.986920e-01 | 0.001 | 0 | 0 |
| Metal ion assimilation from the host | R-HSA-9638482 | 9.986920e-01 | 0.001 | 0 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.987625e-01 | 0.001 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.987679e-01 | 0.001 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.987679e-01 | 0.001 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.988083e-01 | 0.001 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.990149e-01 | 0.000 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.992740e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.992767e-01 | 0.000 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 9.993770e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.994967e-01 | 0.000 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 9.995416e-01 | 0.000 | 0 | 0 |
| Peroxisomal lipid metabolism | R-HSA-390918 | 9.995627e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.996069e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.996360e-01 | 0.000 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.997710e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.997826e-01 | 0.000 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.997830e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 9.997863e-01 | 0.000 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.998271e-01 | 0.000 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 9.998271e-01 | 0.000 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.998516e-01 | 0.000 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.998561e-01 | 0.000 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.998851e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.998958e-01 | 0.000 | 0 | 0 |
| Disease | R-HSA-1643685 | 9.999010e-01 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 9.999218e-01 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 9.999287e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.999409e-01 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 9.999433e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.999622e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.999678e-01 | 0.000 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.999838e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.999863e-01 | 0.000 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.999865e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid metabolism | R-HSA-1660662 | 9.999902e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999939e-01 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 9.999974e-01 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 9.999977e-01 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 9.999986e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999992e-01 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 9.999994e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.999998e-01 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 9.999998e-01 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 9.999998e-01 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 1.000000e+00 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 1.000000e+00 | 0.000 | 0 | 0 |
| Infection with Enterobacteria | R-HSA-9640148 | 1.000000e+00 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 1.000000e+00 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
