P70S6KB

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 Y1062 Sugiyama POTEF A26C1B GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCL_______
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00418 S366 SIGNOR|ELM|EPSD|PSP EEF2K AKtILRGtEEKCGsPQVRTLsGSRPPLLRPLsENSGDENMS
O43852 Y106 Sugiyama CALU GFVtVDELKDWIKFAQKRWIyEDVERQWKGHDLNEDGLVsW
O60343 T749 Sugiyama TBC1D4 AS160 KIAA0603 ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75030 S409 SIGNOR MITF BHLHE32 LLRIQELEMQARAHGLsLIPsTGLCsPDLVNRIIKQEPVLE
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P01100 S362 SIGNOR FOS G0S7 VFTYPEADSFPSCAAAHRKGsSsNEPSSDSLSsPTLLAL__
P01100 S374 SIGNOR FOS G0S7 CAAAHRKGsSsNEPSSDSLSsPTLLAL______________
P03372 S167 SIGNOR ESR1 ESR NR3A1 PAFYRPNsDNRRQGGRERLAsTNDKGSMAMESAKETRYCAV
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04792 S78 EPSD|PSP HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 EPSD|PSP|Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05783 S53 EPSD|PSP KRT18 CYK18 PIG46 AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06899 S37 Sugiyama H2BC11 H2BFR HIST1H2BJ KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07355 Y188 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D RKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVKRKGT
P07900 Y197 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA GEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIGyP
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 Y192 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIGyP
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P09651 S4 PSP HNRNPA1 HNRPA1 _________________MsKsEsPKEPEQLRKLFIGGLsFE
P09651 S6 EPSD|PSP HNRNPA1 HNRPA1 _______________MsKsEsPKEPEQLRKLFIGGLsFEtT
P0CG38 Y1062 Sugiyama POTEI GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0CG39 Y1025 Sugiyama POTEJ GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P12277 Y39 Sugiyama CKB CKBB EFPDLSAHNNHMAKVLtPELyAELRAKSTPSGFTLDDVIQT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P16220 S119 SIGNOR CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19634 S703 SIGNOR SLC9A1 APNH1 NHE1 yLtVPAHKLDsPtMsRARIGsDPLAyEPKEDLPVItIDPAs
P21333 S2152 SIGNOR FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23527 S37 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P23528 Y140 Sugiyama CFL1 CFL SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P23588 S422 SIGNOR EIF4B ERHPsWRsEEtQERERsRtGsEssQtGtstTssRNARRREs
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S106 Sugiyama RPL13 BBC1 OK/SW-cl.46 IHKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLIL
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26639 S702 Sugiyama TARS1 TARS ISGTVNIRTRDNKVHGERtIsEtIERLQQLKEFRSKQAEEE
P27708 S1859 SIGNOR|Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30304 S293 SIGNOR CDC25A LKRPERsQEEsPPGSTKRRKsMsGASPKESTNPEKAHETLH
P30304 S295 SIGNOR CDC25A RPERsQEEsPPGSTKRRKsMsGASPKESTNPEKAHETLHQS
P30305 S353 SIGNOR CDC25B CDC25HU2 LKRLERPQDRDTPVQNKRRRsVtPPEEQQEAEEPKARVLRs
P30305 T355 SIGNOR CDC25B CDC25HU2 RLERPQDRDTPVQNKRRRsVtPPEEQQEAEEPKARVLRsKs
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P32004 S1152 SIGNOR L1CAM CAML1 MIC5 LLLLVLLILCFIKRSKGGKysVKDKEDtQVDsEARPMKDEt
P33778 S37 Sugiyama H2BC3 H2BFF HIST1H2BB KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35659 S301 Sugiyama DEK NVKKADSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPT
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P42345 S2448 SIGNOR MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 NWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEPAH
P42345 T2446 SIGNOR MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 LLNWRLMDTNTKGNKRsRtRtDsYsAGQsVEILDGVELGEP
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P45974 S783 Sugiyama USP5 ISOT IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P46087 S58 Sugiyama NOP2 NOL1 NSUN1 ENsKRLsSRARKRAAKRRLGsVEAPKtNKsPEAKPLPGKLP
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S272 Sugiyama RPL5 MSTP030 VyEKKPKKEVKKKRWNRPKMsLAQKKDRVAQKKAsFLRAQE
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49815 S1798 SIGNOR TSC2 TSC4 AQTPAEPTPGyEVGQRKRLIssVEDFTEFV___________
P49841 S9 SIGNOR|EPSD|PSP GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P50549 S191 SIGNOR ETV1 ER81 PSQSIPDSSYPMDHRFRRQLsEPCNSFPPLPTMPREGRPMY
P50549 S216 SIGNOR ETV1 ER81 SFPPLPTMPREGRPMYQRQMsEPNIPFPPQGFKQEYHDPVY
P50552 T278 SIGNOR VASP SGGGGLMEEMNAMLARRRKAtQVGEKtPKDEsANQEEPEAR
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999 S10 Sugiyama SUB1 PC4 RPO2TC1 ___________MPKSKELVsssssGsDsDsEVDKKLKRKKQ
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57721 S82 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y362 Sugiyama ACTB GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62304 S89 Sugiyama SNRPE KSRKQLGRIMLKGDNITLLQsVsN_________________
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62753 S235 SIGNOR|ELM RPS6 OK/SW-cl.2 KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______
P62753 S236 SIGNOR|ELM RPS6 OK/SW-cl.2 RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P62753 S240 SIGNOR RPS6 OK/SW-cl.2 AKEKRQEQIAKRRRLssLRAstsKsEssQK___________
P62753 S244 SIGNOR RPS6 OK/SW-cl.2 RQEQIAKRRRLssLRAstsKsEssQK_______________
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62937 T157 Sugiyama PPIA CYPA NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y362 Sugiyama ACTG1 ACTG GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 S102 SIGNOR YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S165 Sugiyama YBX1 NSEP1 YB1 YRRYPRRRGPPRNyQQNyQNsEsGEKNEGsEsAPEGQAQQR
P67809 S167 Sugiyama YBX1 NSEP1 YB1 RYPRRRGPPRNyQQNyQNsEsGEKNEGsEsAPEGQAQQRRP
P67809 S174 Sugiyama YBX1 NSEP1 YB1 PPRNyQQNyQNsEsGEKNEGsEsAPEGQAQQRRPyRRRRFP
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78362 S494 Sugiyama SRPK2 GSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLLVN
P78371 S260 SIGNOR CCT2 99D8.1 CCTB ANtGMDtDKIKIFGsRVRVDstAKVAEIEHAEKEKMKEKVE
P84243 S11 SIGNOR H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B __________MARtKQTARKstGGKAPRKQLATKAARKsAP
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q05195 S145 SIGNOR MXD1 MAD EQRHLKRQLEKLGIERIRMDsIGSTVSSERSDSDREEIDVD
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q08945 S657 Sugiyama SSRP1 FACT80 MEKKSTPSRGsSSKSsSRQLsEsFKSKEFVssDEsssGENK
Q13247 S297 Sugiyama SRSF6 SFRS6 SRP55 RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13428 S88 Sugiyama TCOF1 DAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRLAst
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15365 S50 Sugiyama PCBP1 GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15366 S50 Sugiyama PCBP2 GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15633 S283 SIGNOR|EPSD|PSP TARBP2 TRBP CTWDSLRNSVGEKILSLRsCsLGsLGALGPACCRVLSELSE
Q15633 S286 SIGNOR TARBP2 TRBP DSLRNSVGEKILSLRsCsLGsLGALGPACCRVLSELSEEQA
Q15831 S428 SIGNOR STK11 LKB1 PJS GRAPNPARKACSASSKIRRLsACKQQ_______________
Q16778 S37 Sugiyama H2BC21 H2BFQ HIST2H2BE KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q16821 S46 SIGNOR PPP1R3A PP1G CEDEEVTFQPGFSPQPSRRGsDsSEDIYLDTPSSGTRRVsF
Q53EL6 S457 Sugiyama PDCD4 H731 GIISKQLRDLCPSRGRKRFVsEGDGGRLKPESY________
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 Y167 Sugiyama HSP90AB4P GEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIGCL
Q58FF7 Y171 Sugiyama HSP90AB3P HSP90BC GEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIGyP
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6DN03 S37 Sugiyama H2BC20P HIST2H2BC KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6 S37 Sugiyama H2BC19P HIST2H2BD KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6R327 T1135 EPSD|PSP RICTOR KIAA1999 PKGGKLSSESKTSNRRIRtLtEPsVDFNHsDDFtPISTVQK
Q6S8J3 Y1062 Sugiyama POTEE A26C1A POTE2 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7KZF4 S150 Sugiyama SND1 TDRD11 EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IX03 S947 SIGNOR WWC1 KIAA0869 KIBRA sKtFsPGPQSQYVCRLNRsDsDsSTLSKKPPFVRNSLERRS
Q8IX03 T929 SIGNOR WWC1 KIAA0869 KIBRA RVGtPsQGPFLRGSTIIRsKtFsPGPQSQYVCRLNRsDsDs
Q8N122 S719 SIGNOR RPTOR KIAA1303 RAPTOR TTEGGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSL
Q8N122 S721 SIGNOR RPTOR KIAA1303 RAPTOR EGGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQN
Q8N122 S722 SIGNOR RPTOR KIAA1303 RAPTOR GGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQNL
Q8N257 S37 Sugiyama H2BC26 H2BU1 HIST3H2BB KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TB45 S286 SIGNOR DEPTOR DEPDC6 PsKEIKIVSAVRRssMssCGssGyFsssPtLsssPPVLCNP
Q8TB45 S287 SIGNOR DEPTOR DEPDC6 sKEIKIVSAVRRssMssCGssGyFsssPtLsssPPVLCNPK
Q8TB45 S291 SIGNOR DEPTOR DEPDC6 KIVSAVRRssMssCGssGyFsssPtLsssPPVLCNPKSVLK
Q92570 S376 SIGNOR NR4A3 CHN CSMF MINOR NOR1 TEC GMVKEVVRTDsLKGRRGRLPsKPKsPLQQEPsQPsPPsPPI
Q92597 S330 Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92934 S118 SIGNOR BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S153 SIGNOR BAD BBC6 BCL2L8 KsAGtATQMRQSSSWTRVFQsWWDRNLGRGSSAPSQ_____
Q92934 S75 SIGNOR BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q9BY44 S526 Sugiyama EIF2A CDA02 MSTP004 MSTP089 sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BYX7 Y362 Sugiyama POTEKP ACTBL3 FKSG30 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q9H6Z4 S126 SIGNOR RANBP3 EDsDREDGNyCPPVKRERtssLtQFPPSQSEERSSGFRLKP
Q9H788 S317 Sugiyama SH2D4A PPP1R38 SH2A SGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRAGY
Q9UBP6 S27 SIGNOR METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UBS0 S403 Sugiyama RPS6KB2 STK14B AFLGFtYVAPSVLDSIKEGFsFQPKLRsPRRLNssPRAPVs
Q9UBS0 S54 Sugiyama RPS6KB2 STK14B LRAAGLEPVGHyEEVELtETsVNVGPERIGPHCFELLRVLG
Q9UBS0 T51 Sugiyama RPS6KB2 STK14B LAELRAAGLEPVGHyEEVELtETsVNVGPERIGPHCFELLR
Q9UGV2 S334 Sugiyama NDRG3 GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9Y2V2 S52 SIGNOR CARHSP1 sPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCFCR
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin modifying enzymes R-HSA-3247509 5.325451e-11 10.274 0 0
Chromatin organization R-HSA-4839726 1.276362e-10 9.894 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.905272e-09 8.309 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.398472e-08 7.620 1 1
Cell Cycle R-HSA-1640170 2.227695e-08 7.652 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.325711e-08 7.199 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.309521e-07 6.480 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.642423e-07 6.333 0 0
Cellular Senescence R-HSA-2559583 5.088116e-07 6.293 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.448062e-07 6.352 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.099886e-06 5.959 0 0
Cell Cycle Checkpoints R-HSA-69620 1.756402e-06 5.755 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.930517e-06 5.714 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.113091e-06 5.675 0 0
Signal Transduction R-HSA-162582 2.049788e-06 5.688 1 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.216147e-06 5.654 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.885034e-06 5.411 0 0
Cell Cycle, Mitotic R-HSA-69278 4.173914e-06 5.379 0 0
DNA Double Strand Break Response R-HSA-5693606 4.802773e-06 5.319 0 0
Regulation of TP53 Activity R-HSA-5633007 4.956519e-06 5.305 0 0
Apoptotic execution phase R-HSA-75153 5.459723e-06 5.263 0 0
HATs acetylate histones R-HSA-3214847 7.874863e-06 5.104 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.190038e-06 5.087 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.435406e-06 5.074 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.555159e-06 5.020 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.038868e-05 4.983 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.191041e-05 4.924 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.205088e-05 4.919 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.381497e-05 4.860 0 0
Mitotic Prophase R-HSA-68875 1.587275e-05 4.799 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.680052e-05 4.775 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.733714e-05 4.761 0 0
HDACs deacetylate histones R-HSA-3214815 1.885372e-05 4.725 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.145648e-05 4.668 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.143438e-05 4.669 0 0
DNA methylation R-HSA-5334118 2.605376e-05 4.584 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.645146e-05 4.578 0 0
Diseases of programmed cell death R-HSA-9645723 2.575787e-05 4.589 0 0
Meiosis R-HSA-1500620 3.013161e-05 4.521 0 0
Meiotic synapsis R-HSA-1221632 3.378174e-05 4.471 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.250864e-05 4.372 0 0
Packaging Of Telomere Ends R-HSA-171306 4.889511e-05 4.311 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.889511e-05 4.311 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.018842e-05 4.299 0 0
Meiotic recombination R-HSA-912446 6.038819e-05 4.219 0 0
Defective pyroptosis R-HSA-9710421 7.412980e-05 4.130 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.278366e-05 4.138 0 0
Axon guidance R-HSA-422475 7.945596e-05 4.100 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.802117e-05 4.108 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.068581e-05 4.093 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.079576e-05 4.042 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.525586e-05 4.021 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.493167e-05 4.023 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.044014e-04 3.981 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.044014e-04 3.981 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.065167e-04 3.973 0 0
Homology Directed Repair R-HSA-5693538 1.213868e-04 3.916 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.220786e-04 3.913 0 0
ESR-mediated signaling R-HSA-8939211 1.523667e-04 3.817 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.565310e-04 3.805 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.588210e-04 3.799 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.615285e-04 3.792 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.060351e-04 3.686 1 0
Signaling by Hippo R-HSA-2028269 2.148383e-04 3.668 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.225788e-04 3.653 0 0
G2/M Checkpoints R-HSA-69481 2.274097e-04 3.643 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.524901e-04 3.598 1 0
G alpha (12/13) signalling events R-HSA-416482 2.894492e-04 3.538 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.013252e-04 3.521 1 0
HDMs demethylate histones R-HSA-3214842 3.245418e-04 3.489 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.391847e-04 3.470 0 0
Nucleosome assembly R-HSA-774815 3.391847e-04 3.470 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.413563e-04 3.467 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.466599e-04 3.460 0 0
Nervous system development R-HSA-9675108 3.586950e-04 3.445 0 0
Reproduction R-HSA-1474165 3.764857e-04 3.424 0 0
M Phase R-HSA-68886 4.393059e-04 3.357 0 0
NRAGE signals death through JNK R-HSA-193648 4.661815e-04 3.331 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.752564e-04 3.323 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.932727e-04 3.227 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.740111e-04 3.171 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.494022e-04 3.125 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.520942e-04 3.124 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.982875e-04 3.098 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 8.803504e-04 3.055 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.791894e-04 3.009 0 0
Cleavage of the damaged purine R-HSA-110331 9.791894e-04 3.009 0 0
Activation of RAC1 R-HSA-428540 1.005217e-03 2.998 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.079363e-03 2.967 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.109182e-03 2.955 0 0
Depurination R-HSA-73927 1.217512e-03 2.915 0 0
Signaling by WNT R-HSA-195721 1.233514e-03 2.909 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.290503e-03 2.889 0 0
Depyrimidination R-HSA-73928 1.290503e-03 2.889 0 0
Signaling by VEGF R-HSA-194138 1.327030e-03 2.877 0 0
RNA Polymerase I Transcription R-HSA-73864 1.453763e-03 2.838 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.454782e-03 2.837 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.502821e-03 2.823 0 0
Rap1 signalling R-HSA-392517 1.592242e-03 2.798 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.784482e-03 2.748 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.105778e-03 2.677 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.003823e-03 2.698 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.133323e-03 2.671 0 0
Signaling by ROBO receptors R-HSA-376176 2.317284e-03 2.635 0 0
Chromosome Maintenance R-HSA-73886 2.667261e-03 2.574 0 0
Cell junction organization R-HSA-446728 2.727982e-03 2.564 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.924506e-03 2.534 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.262714e-03 2.486 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.224039e-03 2.492 0 0
Death Receptor Signaling R-HSA-73887 3.256982e-03 2.487 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.682357e-03 2.434 1 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.752312e-03 2.426 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.752312e-03 2.426 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.999128e-03 2.398 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.040476e-03 2.394 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.040476e-03 2.394 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.487666e-03 2.348 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.529575e-03 2.344 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.529575e-03 2.344 0 0
RNA Polymerase II Transcription R-HSA-73857 4.613081e-03 2.336 0 0
Netrin-1 signaling R-HSA-373752 4.635566e-03 2.334 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.687914e-03 2.329 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.812101e-03 2.318 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.241449e-03 2.281 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.889889e-03 2.311 0 0
Gene expression (Transcription) R-HSA-74160 5.193313e-03 2.285 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.541969e-03 2.256 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.670496e-03 2.246 1 1
Transcriptional regulation by small RNAs R-HSA-5578749 5.854563e-03 2.233 0 0
Telomere Maintenance R-HSA-157579 5.873622e-03 2.231 0 0
Cell-Cell communication R-HSA-1500931 6.178562e-03 2.209 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.343441e-03 2.198 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.439398e-03 2.191 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.439398e-03 2.191 0 0
mRNA Splicing R-HSA-72172 7.037272e-03 2.153 0 0
mRNA 3'-end processing R-HSA-72187 7.251191e-03 2.140 0 0
CREB phosphorylation R-HSA-199920 7.339277e-03 2.134 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.221081e-03 2.085 0 0
DNA Repair R-HSA-73894 8.266434e-03 2.083 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 8.683161e-03 2.061 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.668750e-03 2.015 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.000679e-02 2.000 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.025959e-02 1.989 0 0
Ub-specific processing proteases R-HSA-5689880 1.037093e-02 1.984 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.076028e-02 1.968 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.083533e-02 1.965 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.090136e-02 1.963 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.150588e-02 1.939 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.165226e-02 1.934 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.188227e-02 1.925 0 0
FOXO-mediated transcription R-HSA-9614085 1.318968e-02 1.880 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.334432e-02 1.875 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.334432e-02 1.875 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.334432e-02 1.875 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.218675e-02 1.914 0 0
DAG and IP3 signaling R-HSA-1489509 1.235862e-02 1.908 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.335786e-02 1.874 0 0
Calmodulin induced events R-HSA-111933 1.335786e-02 1.874 0 0
CaM pathway R-HSA-111997 1.335786e-02 1.874 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.401449e-02 1.853 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.452761e-02 1.838 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.452761e-02 1.838 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.452761e-02 1.838 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.562187e-02 1.806 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.543921e-02 1.811 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.543921e-02 1.811 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.452761e-02 1.838 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.416870e-02 1.849 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.444671e-02 1.840 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.567830e-02 1.805 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.617974e-02 1.791 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.617974e-02 1.791 0 0
RSK activation R-HSA-444257 1.620351e-02 1.790 0 0
Deubiquitination R-HSA-5688426 1.627955e-02 1.788 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.647090e-02 1.783 0 0
Apoptosis R-HSA-109581 1.695325e-02 1.771 0 0
Generic Transcription Pathway R-HSA-212436 1.707749e-02 1.768 0 0
MTOR signalling R-HSA-165159 1.739327e-02 1.760 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.817668e-02 1.740 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.873838e-02 1.727 0 0
Post NMDA receptor activation events R-HSA-438064 1.891207e-02 1.723 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.941855e-02 1.712 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.967471e-02 1.706 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.979308e-02 1.703 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.239351e-02 1.650 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.239351e-02 1.650 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.239351e-02 1.650 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.121707e-02 1.673 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.121707e-02 1.673 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.280901e-02 1.642 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.460760e-02 1.609 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.512959e-02 1.600 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.619949e-02 1.582 0 0
Programmed Cell Death R-HSA-5357801 2.647328e-02 1.577 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.669385e-02 1.574 0 0
Cell-cell junction organization R-HSA-421270 2.702831e-02 1.568 0 0
TRP channels R-HSA-3295583 2.826160e-02 1.549 0 0
Specification of primordial germ cells R-HSA-9827857 2.845533e-02 1.546 0 0
Rab regulation of trafficking R-HSA-9007101 2.872221e-02 1.542 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.913141e-02 1.536 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.913141e-02 1.536 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.913141e-02 1.536 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.913141e-02 1.536 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.913141e-02 1.536 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.923794e-02 1.534 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.029081e-02 1.519 0 0
Developmental Biology R-HSA-1266738 3.118899e-02 1.506 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.242861e-02 1.489 0 0
EPH-Ephrin signaling R-HSA-2682334 3.303300e-02 1.481 0 0
Recycling pathway of L1 R-HSA-437239 3.365643e-02 1.473 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.483016e-02 1.458 0 0
Mitotic Prometaphase R-HSA-68877 3.870312e-02 1.412 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.935153e-02 1.405 0 0
Polo-like kinase mediated events R-HSA-156711 3.483016e-02 1.458 0 0
Ca-dependent events R-HSA-111996 3.644213e-02 1.438 0 0
Adherens junctions interactions R-HSA-418990 3.824982e-02 1.417 0 0
Signaling by NTRKs R-HSA-166520 3.693431e-02 1.433 0 0
Kinesins R-HSA-983189 3.960790e-02 1.402 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.960790e-02 1.402 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.117131e-02 1.385 0 0
DCC mediated attractive signaling R-HSA-418885 4.201580e-02 1.377 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.201580e-02 1.377 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.201580e-02 1.377 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.201580e-02 1.377 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.201580e-02 1.377 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.208581e-02 1.376 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.208581e-02 1.376 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.355093e-02 1.361 0 0
PLC beta mediated events R-HSA-112043 4.389381e-02 1.358 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.470901e-02 1.350 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.470901e-02 1.350 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.470901e-02 1.350 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.595157e-02 1.338 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.595157e-02 1.338 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.595157e-02 1.338 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.595157e-02 1.338 0 0
Dopamine receptors R-HSA-390651 4.595157e-02 1.338 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.679986e-02 1.330 0 0
Ion homeostasis R-HSA-5578775 4.819011e-02 1.317 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 4.832595e-02 1.316 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.849787e-02 1.314 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.025473e-02 1.299 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.025473e-02 1.299 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.025473e-02 1.299 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.025473e-02 1.299 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.220513e-02 1.282 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.697108e-02 1.244 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.540939e-02 1.256 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.139327e-02 1.289 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.805524e-02 1.236 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.805524e-02 1.236 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.805524e-02 1.236 0 0
Semaphorin interactions R-HSA-373755 5.342934e-02 1.272 0 0
Amyloid fiber formation R-HSA-977225 5.225812e-02 1.282 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.871572e-02 1.231 0 0
Neurexins and neuroligins R-HSA-6794361 5.871572e-02 1.231 0 0
Type I hemidesmosome assembly R-HSA-446107 5.924454e-02 1.227 0 0
ERK/MAPK targets R-HSA-198753 5.936034e-02 1.227 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.945720e-02 1.226 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.945720e-02 1.226 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 6.019003e-02 1.220 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.019003e-02 1.220 0 0
RET signaling R-HSA-8853659 6.230701e-02 1.205 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.267306e-02 1.203 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.641516e-02 1.178 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.598640e-02 1.119 0 0
WNT mediated activation of DVL R-HSA-201688 7.598640e-02 1.119 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.598640e-02 1.119 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.657630e-02 1.116 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.413117e-02 1.130 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.492311e-02 1.188 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.026726e-02 1.153 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.524893e-02 1.123 0 0
G0 and Early G1 R-HSA-1538133 6.804473e-02 1.167 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.524893e-02 1.123 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.598640e-02 1.119 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.413117e-02 1.130 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.804473e-02 1.167 0 0
G-protein mediated events R-HSA-112040 7.658243e-02 1.116 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.220239e-02 1.141 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 7.657630e-02 1.116 0 0
Co-stimulation by CD28 R-HSA-389356 7.165579e-02 1.145 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.521710e-02 1.124 0 0
NGF-stimulated transcription R-HSA-9031628 7.165579e-02 1.145 0 0
NrCAM interactions R-HSA-447038 6.641516e-02 1.178 0 0
Unwinding of DNA R-HSA-176974 7.598640e-02 1.119 0 0
L1CAM interactions R-HSA-373760 6.624977e-02 1.179 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.438967e-02 1.128 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.697977e-02 1.114 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.697977e-02 1.114 0 0
Cardiogenesis R-HSA-9733709 7.697977e-02 1.114 0 0
G2/M Transition R-HSA-69275 7.701152e-02 1.113 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.719982e-02 1.112 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.853062e-02 1.105 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.941728e-02 1.100 0 0
mTORC1-mediated signalling R-HSA-166208 8.042880e-02 1.095 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.497883e-02 1.071 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.608309e-02 1.065 0 0
Signaling by Interleukins R-HSA-449147 8.622283e-02 1.064 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 9.836014e-02 1.007 0 0
Regulation of cortical dendrite branching R-HSA-8985801 9.836014e-02 1.007 0 0
Potassium transport channels R-HSA-1296067 9.836014e-02 1.007 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 9.030094e-02 1.044 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 9.030094e-02 1.044 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 9.030094e-02 1.044 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 9.030094e-02 1.044 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.662316e-02 1.062 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.662316e-02 1.062 0 0
PKA activation R-HSA-163615 8.662316e-02 1.062 0 0
PKA activation in glucagon signalling R-HSA-164378 8.662316e-02 1.062 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.052922e-01 0.978 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.550637e-02 1.020 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.550637e-02 1.020 0 0
Striated Muscle Contraction R-HSA-390522 8.659826e-02 1.062 0 0
Activation of the pre-replicative complex R-HSA-68962 1.073782e-01 0.969 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.689945e-02 1.014 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.689945e-02 1.014 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.713875e-02 1.013 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.399633e-02 1.027 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.223839e-02 1.035 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.223839e-02 1.035 0 0
Centrosome maturation R-HSA-380287 8.822252e-02 1.054 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.662316e-02 1.062 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.760799e-02 1.057 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.058121e-02 1.043 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.759525e-02 1.058 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.078780e-01 0.967 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 9.483604e-02 1.023 0 0
Regulation of CDH11 function R-HSA-9762292 9.483604e-02 1.023 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.007096e-01 0.997 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.659826e-02 1.062 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.078780e-01 0.967 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 9.200070e-02 1.036 0 0
Neurodegenerative Diseases R-HSA-8863678 1.052922e-01 0.978 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.052922e-01 0.978 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.550637e-02 1.020 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.820098e-02 1.055 0 0
Muscle contraction R-HSA-397014 1.050944e-01 0.978 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.662316e-02 1.062 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.025425e-01 0.989 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.065411e-01 0.972 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.662316e-02 1.062 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.030094e-02 1.044 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.081694e-01 0.966 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.083351e-01 0.965 0 0
Membrane Trafficking R-HSA-199991 1.083574e-01 0.965 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.088904e-01 0.963 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.107120e-01 0.956 0 0
Base Excision Repair R-HSA-73884 1.107120e-01 0.956 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.131488e-01 0.946 0 0
Signaling by ALK in cancer R-HSA-9700206 1.131488e-01 0.946 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.135906e-01 0.945 0 0
S Phase R-HSA-69242 1.148827e-01 0.940 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.148827e-01 0.940 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.156543e-01 0.937 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.157305e-01 0.937 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.159215e-01 0.936 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.172001e-01 0.931 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.172001e-01 0.931 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.191077e-01 0.924 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.191077e-01 0.924 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.191077e-01 0.924 0 0
Interleukin-7 signaling R-HSA-1266695 1.191077e-01 0.924 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.200039e-01 0.921 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.222933e-01 0.913 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.233580e-01 0.909 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.233580e-01 0.909 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.233580e-01 0.909 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.233580e-01 0.909 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.233580e-01 0.909 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.233580e-01 0.909 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.233580e-01 0.909 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.259005e-01 0.900 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.265541e-01 0.898 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.271056e-01 0.896 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.271695e-01 0.896 0 0
Differentiation of T cells R-HSA-9945266 1.271695e-01 0.896 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.285077e-01 0.891 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.322123e-01 0.879 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.322123e-01 0.879 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.466605e-01 0.834 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.466605e-01 0.834 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.466605e-01 0.834 0 0
SOS-mediated signalling R-HSA-112412 1.466605e-01 0.834 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.466605e-01 0.834 0 0
Regulation by c-FLIP R-HSA-3371378 1.782150e-01 0.749 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.782150e-01 0.749 0 0
Dimerization of procaspase-8 R-HSA-69416 1.782150e-01 0.749 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.782150e-01 0.749 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.782150e-01 0.749 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.382708e-01 0.859 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.382708e-01 0.859 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.624918e-01 0.789 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.624918e-01 0.789 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.624918e-01 0.789 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.624918e-01 0.789 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.624918e-01 0.789 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.624918e-01 0.789 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.495247e-01 0.825 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.495247e-01 0.825 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.493555e-01 0.826 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.493555e-01 0.826 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.493555e-01 0.826 0 0
Telomere Extension By Telomerase R-HSA-171319 1.657055e-01 0.781 0 0
HIV elongation arrest and recovery R-HSA-167287 1.657055e-01 0.781 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.657055e-01 0.781 0 0
Integrin signaling R-HSA-354192 1.475375e-01 0.831 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.623525e-01 0.790 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.583075e-01 0.800 0 0
RAF activation R-HSA-5673000 1.778266e-01 0.750 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.553983e-01 0.809 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.498739e-01 0.824 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.498739e-01 0.824 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.768293e-01 0.752 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.675100e-01 0.776 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.466605e-01 0.834 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.504656e-01 0.823 0 0
Adrenoceptors R-HSA-390696 1.782150e-01 0.749 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.623525e-01 0.790 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.678536e-01 0.775 0 0
DNA Replication R-HSA-69306 1.457415e-01 0.836 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.678536e-01 0.775 0 0
G1/S Transition R-HSA-69206 1.692370e-01 0.772 0 0
G-protein beta:gamma signalling R-HSA-397795 1.475375e-01 0.831 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.579430e-01 0.801 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.382708e-01 0.859 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.493555e-01 0.826 0 0
Metabolism of RNA R-HSA-8953854 1.479959e-01 0.830 0 0
Protein ubiquitination R-HSA-8852135 1.401428e-01 0.853 0 0
Regulation of PTEN localization R-HSA-8948747 1.466605e-01 0.834 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.782150e-01 0.749 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.782150e-01 0.749 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.512910e-01 0.820 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.677922e-01 0.775 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.420459e-01 0.848 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.738518e-01 0.760 0 0
Sodium/Proton exchangers R-HSA-425986 1.782150e-01 0.749 0 0
Gene Silencing by RNA R-HSA-211000 1.643851e-01 0.784 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.783393e-01 0.749 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.804193e-01 0.744 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.804193e-01 0.744 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.804193e-01 0.744 0 0
Signaling by RAS mutants R-HSA-6802949 1.804193e-01 0.744 0 0
Diseases of DNA repair R-HSA-9675135 1.804193e-01 0.744 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.315051e-01 0.635 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.315051e-01 0.635 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.315051e-01 0.635 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.315051e-01 0.635 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.315051e-01 0.635 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.315051e-01 0.635 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.315051e-01 0.635 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.875733e-01 0.727 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.875733e-01 0.727 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.875733e-01 0.727 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.875733e-01 0.727 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.875733e-01 0.727 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.875733e-01 0.727 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.263161e-01 0.486 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.263161e-01 0.486 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.263161e-01 0.486 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.263161e-01 0.486 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.263161e-01 0.486 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.263161e-01 0.486 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.263161e-01 0.486 0 0
Intestinal infectious diseases R-HSA-8942233 3.263161e-01 0.486 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.263161e-01 0.486 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.263161e-01 0.486 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.263161e-01 0.486 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.263161e-01 0.486 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.263161e-01 0.486 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.263161e-01 0.486 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.263161e-01 0.486 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.263161e-01 0.486 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.263161e-01 0.486 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.263161e-01 0.486 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.263161e-01 0.486 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.354119e-01 0.628 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.354119e-01 0.628 0 0
IRS activation R-HSA-74713 2.354119e-01 0.628 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.354119e-01 0.628 0 0
Lipophagy R-HSA-9613354 2.114021e-01 0.675 0 0
CASP8 activity is inhibited R-HSA-5218900 2.114021e-01 0.675 0 0
ALK mutants bind TKIs R-HSA-9700645 2.114021e-01 0.675 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.838155e-01 0.547 0 0
Signaling by MAPK mutants R-HSA-9652817 2.838155e-01 0.547 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.094349e-01 0.388 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.094349e-01 0.388 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.094349e-01 0.388 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.094349e-01 0.388 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.094349e-01 0.388 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.094349e-01 0.388 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 4.094349e-01 0.388 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.094349e-01 0.388 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.094349e-01 0.388 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.094349e-01 0.388 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.094349e-01 0.388 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.094349e-01 0.388 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.094349e-01 0.388 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.094349e-01 0.388 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.094349e-01 0.388 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.094349e-01 0.388 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.094349e-01 0.388 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.094349e-01 0.388 0 0
Formation of axial mesoderm R-HSA-9796292 1.881088e-01 0.726 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.881088e-01 0.726 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.881088e-01 0.726 0 0
Formation of apoptosome R-HSA-111458 2.457801e-01 0.609 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.457801e-01 0.609 0 0
PI3K/AKT activation R-HSA-198203 2.457801e-01 0.609 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.457801e-01 0.609 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.457801e-01 0.609 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.149045e-01 0.668 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.319171e-01 0.479 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.319171e-01 0.479 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.809369e-01 0.551 0 0
Signaling by APC mutants R-HSA-4839744 2.809369e-01 0.551 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.809369e-01 0.551 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.809369e-01 0.551 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.809369e-01 0.551 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.426596e-01 0.615 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.426596e-01 0.615 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.426596e-01 0.615 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.121295e-01 0.673 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.869402e-01 0.728 0 0
Deadenylation of mRNA R-HSA-429947 2.068878e-01 0.684 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.711569e-01 0.567 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.164964e-01 0.500 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.164964e-01 0.500 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.790549e-01 0.421 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.790549e-01 0.421 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.790549e-01 0.421 0 0
PTK6 Expression R-HSA-8849473 3.790549e-01 0.421 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.790549e-01 0.421 0 0
The NLRP1 inflammasome R-HSA-844455 4.823027e-01 0.317 0 0
Axonal growth stimulation R-HSA-209563 4.823027e-01 0.317 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.823027e-01 0.317 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.823027e-01 0.317 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.823027e-01 0.317 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.823027e-01 0.317 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.823027e-01 0.317 0 0
Invadopodia formation R-HSA-8941237 4.823027e-01 0.317 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.823027e-01 0.317 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.823027e-01 0.317 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.006069e-01 0.698 0 0
Tight junction interactions R-HSA-420029 2.275491e-01 0.643 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.001858e-01 0.523 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.001858e-01 0.523 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.521215e-01 0.453 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.521215e-01 0.453 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.521215e-01 0.453 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.277889e-01 0.642 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.706534e-01 0.568 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.247348e-01 0.372 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.247348e-01 0.372 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.247348e-01 0.372 0 0
Activation of RAS in B cells R-HSA-1169092 4.247348e-01 0.372 0 0
Formation of annular gap junctions R-HSA-196025 4.247348e-01 0.372 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.575707e-01 0.589 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.875154e-01 0.412 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.635796e-01 0.579 0 0
Ephrin signaling R-HSA-3928664 3.590471e-01 0.445 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.356093e-01 0.474 0 0
HIV Transcription Elongation R-HSA-167169 2.820680e-01 0.550 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.820680e-01 0.550 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.820680e-01 0.550 0 0
HSF1-dependent transactivation R-HSA-3371571 2.547069e-01 0.594 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.315482e-01 0.635 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.211915e-01 0.655 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.383833e-01 0.471 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.613034e-01 0.442 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.885158e-01 0.411 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.224213e-01 0.374 0 0
Gap junction degradation R-HSA-190873 4.685992e-01 0.329 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.685992e-01 0.329 0 0
Regulation of gap junction activity R-HSA-191650 5.461834e-01 0.263 0 0
HCN channels R-HSA-1296061 5.461834e-01 0.263 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.461834e-01 0.263 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.461834e-01 0.263 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.461834e-01 0.263 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.461834e-01 0.263 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 5.461834e-01 0.263 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.461834e-01 0.263 0 0
snRNP Assembly R-HSA-191859 2.726909e-01 0.564 0 0
Metabolism of non-coding RNA R-HSA-194441 2.726909e-01 0.564 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.199645e-01 0.495 0 0
Trafficking of AMPA receptors R-HSA-399719 3.614156e-01 0.442 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.392653e-01 0.469 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.177918e-01 0.379 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.404588e-01 0.619 0 0
Transcription of the HIV genome R-HSA-167172 3.035915e-01 0.518 0 0
Erythropoietin activates RAS R-HSA-9027284 4.566211e-01 0.340 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.566211e-01 0.340 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.566211e-01 0.340 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.566211e-01 0.340 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.127174e-01 0.384 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.012685e-01 0.521 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 4.467310e-01 0.350 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.104008e-01 0.292 0 0
2-LTR circle formation R-HSA-164843 5.104008e-01 0.292 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.104008e-01 0.292 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.382233e-01 0.358 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.468086e-01 0.460 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.258708e-01 0.487 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.215329e-01 0.493 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.415702e-01 0.467 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.306816e-01 0.366 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.306816e-01 0.366 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.899334e-01 0.310 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 4.899334e-01 0.310 0 0
Phosphorylation of the APC/C R-HSA-176412 4.899334e-01 0.310 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.899334e-01 0.310 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.616595e-01 0.442 0 0
Attenuation phase R-HSA-3371568 4.238557e-01 0.373 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.752052e-01 0.323 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.634659e-01 0.334 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.634659e-01 0.334 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.008787e-01 0.397 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.108028e-01 0.386 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.762326e-01 0.322 0 0
Signaling by Erythropoietin R-HSA-9006335 4.883588e-01 0.311 0 0
Late endosomal microautophagy R-HSA-9615710 4.883588e-01 0.311 0 0
Notch-HLH transcription pathway R-HSA-350054 5.031022e-01 0.298 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.222102e-01 0.282 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.222102e-01 0.282 0 0
Cellular response to heat stress R-HSA-3371556 4.164366e-01 0.380 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.128242e-01 0.290 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.367930e-01 0.270 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.367930e-01 0.270 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.176384e-01 0.286 0 0
Viral mRNA Translation R-HSA-192823 5.355717e-01 0.271 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.880331e-01 0.726 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.815328e-01 0.418 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.575707e-01 0.589 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.658497e-01 0.332 0 0
Downstream signal transduction R-HSA-186763 3.614156e-01 0.442 0 0
Hedgehog 'off' state R-HSA-5610787 4.945178e-01 0.306 0 0
Specification of the neural plate border R-HSA-9834899 2.121295e-01 0.673 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.238557e-01 0.373 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.238557e-01 0.373 0 0
Formation of definitive endoderm R-HSA-9823730 2.357275e-01 0.628 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.277889e-01 0.642 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.215329e-01 0.493 0 0
Circadian clock R-HSA-9909396 4.836608e-01 0.315 0 0
Extension of Telomeres R-HSA-180786 5.207314e-01 0.283 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.164964e-01 0.500 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.979402e-01 0.400 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.222102e-01 0.282 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.488348e-01 0.604 0 0
Generation of second messenger molecules R-HSA-202433 2.820680e-01 0.550 0 0
Adipogenesis R-HSA-9843745 3.020167e-01 0.520 0 0
Synaptic adhesion-like molecules R-HSA-8849932 1.893467e-01 0.723 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.247348e-01 0.372 0 0
Signaling by ERBB2 R-HSA-1227986 2.881169e-01 0.540 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.315482e-01 0.635 0 0
Signaling by PTK6 R-HSA-8848021 2.315482e-01 0.635 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.339739e-01 0.476 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.354119e-01 0.628 0 0
Myogenesis R-HSA-525793 2.488348e-01 0.604 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.715160e-01 0.566 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.129213e-01 0.505 0 0
Frs2-mediated activation R-HSA-170968 1.881088e-01 0.726 0 0
p75NTR signals via NF-kB R-HSA-193639 4.566211e-01 0.340 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.206572e-01 0.283 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.510831e-01 0.600 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.457801e-01 0.609 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.875154e-01 0.412 0 0
MAP2K and MAPK activation R-HSA-5674135 3.199645e-01 0.495 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.506429e-01 0.346 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.371913e-01 0.359 0 0
Apoptotic factor-mediated response R-HSA-111471 1.893467e-01 0.723 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.001858e-01 0.523 0 0
RMTs methylate histone arginines R-HSA-3214858 2.508159e-01 0.601 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.870431e-01 0.412 0 0
Regulated Necrosis R-HSA-5218859 3.035915e-01 0.518 0 0
Processing of SMDT1 R-HSA-8949664 1.881088e-01 0.726 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.457801e-01 0.609 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.685992e-01 0.329 0 0
Peptide chain elongation R-HSA-156902 2.158652e-01 0.666 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.177918e-01 0.379 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.120604e-01 0.674 0 0
DNA strand elongation R-HSA-69190 3.845302e-01 0.415 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.899334e-01 0.310 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.535670e-01 0.343 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.222102e-01 0.282 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.590840e-01 0.338 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.996329e-01 0.301 0 0
TNF signaling R-HSA-75893 3.372588e-01 0.472 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.961896e-01 0.707 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.850593e-01 0.545 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.380528e-01 0.623 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.384876e-01 0.470 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.811994e-01 0.419 0 0
TCR signaling R-HSA-202403 3.460843e-01 0.461 0 0
Interleukin-1 signaling R-HSA-9020702 4.057248e-01 0.392 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.551875e-01 0.450 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.354119e-01 0.628 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.114021e-01 0.675 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.114021e-01 0.675 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.838155e-01 0.547 0 0
cGMP effects R-HSA-418457 2.149045e-01 0.668 0 0
DARPP-32 events R-HSA-180024 1.828078e-01 0.738 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 3.521215e-01 0.453 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.685992e-01 0.329 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.566211e-01 0.340 0 0
Orc1 removal from chromatin R-HSA-68949 3.933518e-01 0.405 0 0
Separation of Sister Chromatids R-HSA-2467813 2.925293e-01 0.534 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.712330e-01 0.430 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.471842e-01 0.262 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.454074e-01 0.263 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.711569e-01 0.567 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.127174e-01 0.384 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.551875e-01 0.450 0 0
Signal attenuation R-HSA-74749 2.457801e-01 0.609 0 0
Repression of WNT target genes R-HSA-4641265 3.521215e-01 0.453 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.023575e-01 0.694 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.958541e-01 0.708 0 0
Opioid Signalling R-HSA-111885 2.625395e-01 0.581 0 0
DAP12 signaling R-HSA-2424491 5.128242e-01 0.290 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.880331e-01 0.726 0 0
Signaling by WNT in cancer R-HSA-4791275 3.845302e-01 0.415 0 0
Prolonged ERK activation events R-HSA-169893 2.711569e-01 0.567 0 0
Calcineurin activates NFAT R-HSA-2025928 2.114021e-01 0.675 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.838155e-01 0.547 0 0
HDL assembly R-HSA-8963896 2.149045e-01 0.668 0 0
Abacavir transmembrane transport R-HSA-2161517 3.319171e-01 0.479 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.006069e-01 0.698 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.247348e-01 0.372 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.247348e-01 0.372 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.575707e-01 0.589 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.392653e-01 0.469 0 0
Nuclear RNA decay R-HSA-9930044 4.076449e-01 0.390 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.306816e-01 0.366 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.063029e-01 0.391 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.063029e-01 0.391 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.063029e-01 0.391 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.063029e-01 0.391 0 0
Ca2+ pathway R-HSA-4086398 4.996329e-01 0.301 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.392653e-01 0.469 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.935273e-01 0.713 0 0
Integration of energy metabolism R-HSA-163685 3.680777e-01 0.434 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.023575e-01 0.694 0 0
Triglyceride catabolism R-HSA-163560 4.986152e-01 0.302 0 0
G1 Phase R-HSA-69236 5.272970e-01 0.278 0 0
Cyclin D associated events in G1 R-HSA-69231 5.272970e-01 0.278 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.128242e-01 0.290 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.935273e-01 0.713 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.696894e-01 0.569 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.511369e-01 0.455 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.761063e-01 0.322 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.761063e-01 0.322 0 0
Signaling by FGFR in disease R-HSA-1226099 5.157316e-01 0.288 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.164964e-01 0.500 0 0
Mitotic Anaphase R-HSA-68882 2.617452e-01 0.582 0 0
Pyroptosis R-HSA-5620971 4.634659e-01 0.334 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.875733e-01 0.727 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.838155e-01 0.547 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.426596e-01 0.615 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.848349e-01 0.545 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.575707e-01 0.589 0 0
Eukaryotic Translation Termination R-HSA-72764 4.247951e-01 0.372 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.934108e-01 0.405 0 0
Toll-like Receptor Cascades R-HSA-168898 4.232780e-01 0.373 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.835396e-01 0.736 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.869402e-01 0.728 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.008808e-01 0.522 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 4.883588e-01 0.311 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.222102e-01 0.282 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.206572e-01 0.283 0 0
Interleukin-1 family signaling R-HSA-446652 3.163816e-01 0.500 0 0
Autophagy R-HSA-9612973 5.204658e-01 0.284 0 0
Adaptive Immune System R-HSA-1280218 4.249768e-01 0.372 0 0
Signalling to ERKs R-HSA-187687 4.762326e-01 0.322 0 0
GPVI-mediated activation cascade R-HSA-114604 3.393612e-01 0.469 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.673767e-01 0.573 0 0
Interleukin-2 family signaling R-HSA-451927 4.238557e-01 0.373 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.775291e-01 0.557 0 0
mRNA Editing R-HSA-75072 4.685992e-01 0.329 0 0
Neuronal System R-HSA-112316 5.364453e-01 0.270 0 0
Signaling by NOTCH1 R-HSA-1980143 5.474416e-01 0.262 0 0
Syndecan interactions R-HSA-3000170 1.869402e-01 0.728 0 0
Cardiac conduction R-HSA-5576891 3.020167e-01 0.520 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.179007e-01 0.498 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.281554e-01 0.642 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.315051e-01 0.635 0 0
Inhibition of PKR R-HSA-169131 2.315051e-01 0.635 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.875733e-01 0.727 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.263161e-01 0.486 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.114021e-01 0.675 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.094349e-01 0.388 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.094349e-01 0.388 0 0
C6 deamination of adenosine R-HSA-75102 4.094349e-01 0.388 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.881088e-01 0.726 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.881088e-01 0.726 0 0
Bicarbonate transporters R-HSA-425381 2.809369e-01 0.551 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.711569e-01 0.567 0 0
Signaling by AXIN mutants R-HSA-4839735 3.164964e-01 0.500 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.164964e-01 0.500 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.823027e-01 0.317 0 0
MET interacts with TNS proteins R-HSA-8875513 4.823027e-01 0.317 0 0
TGFBR3 expression R-HSA-9839394 2.275491e-01 0.643 0 0
Signaling by LTK R-HSA-9842663 3.521215e-01 0.453 0 0
Co-stimulation by ICOS R-HSA-9927354 4.247348e-01 0.372 0 0
TBC/RABGAPs R-HSA-8854214 2.342349e-01 0.630 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.155193e-01 0.501 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.224213e-01 0.374 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.685992e-01 0.329 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.461834e-01 0.263 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.870431e-01 0.412 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.027064e-01 0.395 0 0
Cristae formation R-HSA-8949613 4.382233e-01 0.358 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.899334e-01 0.310 0 0
Mitochondrial biogenesis R-HSA-1592230 3.673196e-01 0.435 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.968349e-01 0.401 0 0
Platelet calcium homeostasis R-HSA-418360 4.883588e-01 0.311 0 0
Disorders of Developmental Biology R-HSA-9675151 5.222102e-01 0.282 0 0
Cellular responses to stress R-HSA-2262752 3.346141e-01 0.475 0 0
MAPK family signaling cascades R-HSA-5683057 2.222723e-01 0.653 0 0
Regulation of insulin secretion R-HSA-422356 4.667442e-01 0.331 0 0
MAP kinase activation R-HSA-450294 2.048117e-01 0.689 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.059262e-01 0.296 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.677713e-01 0.572 0 0
Cellular responses to stimuli R-HSA-8953897 2.762984e-01 0.559 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.076449e-01 0.390 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.222102e-01 0.282 0 0
The NLRP3 inflammasome R-HSA-844456 3.885158e-01 0.411 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.076449e-01 0.390 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.848349e-01 0.545 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.978595e-01 0.526 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.685992e-01 0.329 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.035915e-01 0.518 0 0
Interleukin-17 signaling R-HSA-448424 3.339739e-01 0.476 0 0
Inflammasomes R-HSA-622312 4.634659e-01 0.334 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.222102e-01 0.282 0 0
Formation of the nephric duct R-HSA-9830364 3.870431e-01 0.412 0 0
FLT3 Signaling R-HSA-9607240 3.008808e-01 0.522 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.457801e-01 0.609 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.180691e-01 0.661 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.519325e-01 0.454 0 0
Interleukin-1 processing R-HSA-448706 2.114021e-01 0.675 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.838155e-01 0.547 0 0
CHL1 interactions R-HSA-447041 3.790549e-01 0.421 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.875154e-01 0.412 0 0
Heme signaling R-HSA-9707616 2.180085e-01 0.662 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.685992e-01 0.329 0 0
Protein hydroxylation R-HSA-9629569 4.177918e-01 0.379 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.535670e-01 0.343 0 0
Amine ligand-binding receptors R-HSA-375280 5.272970e-01 0.278 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.457801e-01 0.609 0 0
Sensory processing of sound R-HSA-9659379 3.616595e-01 0.442 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.063029e-01 0.391 0 0
Signaling by ERBB4 R-HSA-1236394 5.157316e-01 0.288 0 0
Co-inhibition by PD-1 R-HSA-389948 3.668846e-01 0.435 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.372588e-01 0.472 0 0
Aquaporin-mediated transport R-HSA-445717 4.236842e-01 0.373 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.493967e-01 0.457 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.716148e-01 0.430 0 0
Glycolysis R-HSA-70171 3.922410e-01 0.406 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.263161e-01 0.486 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.263161e-01 0.486 0 0
DSCAM interactions R-HSA-376172 4.094349e-01 0.388 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.457801e-01 0.609 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.823027e-01 0.317 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.823027e-01 0.317 0 0
Alpha-defensins R-HSA-1462054 4.247348e-01 0.372 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.685992e-01 0.329 0 0
ARMS-mediated activation R-HSA-170984 4.685992e-01 0.329 0 0
NADE modulates death signalling R-HSA-205025 5.461834e-01 0.263 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.104008e-01 0.292 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.883588e-01 0.311 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.491156e-01 0.348 0 0
Activation of BH3-only proteins R-HSA-114452 5.128242e-01 0.290 0 0
PI Metabolism R-HSA-1483255 2.401593e-01 0.620 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.575707e-01 0.589 0 0
Stimuli-sensing channels R-HSA-2672351 2.404588e-01 0.619 0 0
Signaling by TGFBR3 R-HSA-9839373 4.175850e-01 0.379 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.762326e-01 0.322 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.875154e-01 0.412 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.331125e-01 0.273 0 0
Histamine receptors R-HSA-390650 4.823027e-01 0.317 0 0
Interleukin-37 signaling R-HSA-9008059 2.006069e-01 0.698 0 0
G1/S-Specific Transcription R-HSA-69205 2.105895e-01 0.677 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.685992e-01 0.329 0 0
Selenocysteine synthesis R-HSA-2408557 5.082984e-01 0.294 0 0
Formation of the anterior neural plate R-HSA-9823739 4.566211e-01 0.340 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.838155e-01 0.547 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.094349e-01 0.388 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.094349e-01 0.388 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.790549e-01 0.421 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.823027e-01 0.317 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.823027e-01 0.317 0 0
Interleukin-18 signaling R-HSA-9012546 4.247348e-01 0.372 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.752052e-01 0.323 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.202339e-01 0.657 0 0
PTEN Regulation R-HSA-6807070 4.021083e-01 0.396 0 0
Potential therapeutics for SARS R-HSA-9679191 5.387908e-01 0.269 0 0
FasL/ CD95L signaling R-HSA-75157 4.823027e-01 0.317 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.423062e-01 0.266 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.590471e-01 0.445 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.467310e-01 0.350 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.682614e-01 0.434 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.381922e-01 0.471 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 3.875154e-01 0.412 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.224213e-01 0.374 0 0
Interleukin-12 signaling R-HSA-9020591 5.474416e-01 0.262 0 0
Signaling by Leptin R-HSA-2586552 5.104008e-01 0.292 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.490360e-01 0.260 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.499029e-01 0.260 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.499809e-01 0.260 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.499809e-01 0.260 0 0
LGI-ADAM interactions R-HSA-5682910 5.499809e-01 0.260 0 0
Formation of the posterior neural plate R-HSA-9832991 5.499809e-01 0.260 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.499809e-01 0.260 0 0
Synthesis of PI R-HSA-1483226 5.499809e-01 0.260 0 0
PECAM1 interactions R-HSA-210990 5.499809e-01 0.260 0 0
Smooth Muscle Contraction R-HSA-445355 5.516024e-01 0.258 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.533348e-01 0.257 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.533348e-01 0.257 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.533348e-01 0.257 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.533348e-01 0.257 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.556687e-01 0.255 0 0
Glucose metabolism R-HSA-70326 5.562920e-01 0.255 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.567920e-01 0.254 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.567920e-01 0.254 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.602047e-01 0.252 0 0
Signaling by TGFB family members R-HSA-9006936 5.639813e-01 0.249 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.663986e-01 0.247 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.824351e-01 0.235 0 0
Long-term potentiation R-HSA-9620244 5.824351e-01 0.235 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.830071e-01 0.234 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.830071e-01 0.234 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.830071e-01 0.234 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.832184e-01 0.234 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.832184e-01 0.234 0 0
Aggrephagy R-HSA-9646399 5.842435e-01 0.233 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.872513e-01 0.231 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.872513e-01 0.231 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.872513e-01 0.231 0 0
ERKs are inactivated R-HSA-202670 5.872513e-01 0.231 0 0
NF-kB is activated and signals survival R-HSA-209560 5.872513e-01 0.231 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.872513e-01 0.231 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.872513e-01 0.231 0 0
Integration of provirus R-HSA-162592 5.872513e-01 0.231 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.895267e-01 0.229 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.954827e-01 0.225 0 0
PTK6 Down-Regulation R-HSA-8849472 6.021848e-01 0.220 0 0
G2 Phase R-HSA-68911 6.021848e-01 0.220 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.021848e-01 0.220 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.021848e-01 0.220 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.021848e-01 0.220 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.021848e-01 0.220 0 0
Activation of AKT2 R-HSA-165158 6.021848e-01 0.220 0 0
PTK6 Activates STAT3 R-HSA-8849474 6.021848e-01 0.220 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.021848e-01 0.220 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.021848e-01 0.220 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.021848e-01 0.220 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.021848e-01 0.220 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.044543e-01 0.219 0 0
Metal ion SLC transporters R-HSA-425410 6.045353e-01 0.219 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.051559e-01 0.218 0 0
IGF1R signaling cascade R-HSA-2428924 6.059929e-01 0.218 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.070964e-01 0.217 0 0
Signaling by NOTCH R-HSA-157118 6.073544e-01 0.217 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.117968e-01 0.213 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.117968e-01 0.213 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.117968e-01 0.213 0 0
HIV Life Cycle R-HSA-162587 6.146016e-01 0.211 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.218859e-01 0.206 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.221240e-01 0.206 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.221793e-01 0.206 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.221793e-01 0.206 0 0
Polymerase switching R-HSA-69091 6.221793e-01 0.206 0 0
Leading Strand Synthesis R-HSA-69109 6.221793e-01 0.206 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.221793e-01 0.206 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.221793e-01 0.206 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.221793e-01 0.206 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.221793e-01 0.206 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.221793e-01 0.206 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.221793e-01 0.206 0 0
Disorders of Nervous System Development R-HSA-9697154 6.221793e-01 0.206 0 0
Pervasive developmental disorders R-HSA-9005895 6.221793e-01 0.206 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.221793e-01 0.206 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.221793e-01 0.206 0 0
Estrogen biosynthesis R-HSA-193144 6.221793e-01 0.206 0 0
Interleukin-15 signaling R-HSA-8983432 6.221793e-01 0.206 0 0
OAS antiviral response R-HSA-8983711 6.221793e-01 0.206 0 0
IRS-mediated signalling R-HSA-112399 6.221987e-01 0.206 0 0
HCMV Early Events R-HSA-9609690 6.232813e-01 0.205 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.241171e-01 0.205 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.241171e-01 0.205 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.241171e-01 0.205 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.266147e-01 0.203 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.266147e-01 0.203 0 0
Nuclear import of Rev protein R-HSA-180746 6.266147e-01 0.203 0 0
MHC class II antigen presentation R-HSA-2132295 6.289266e-01 0.201 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.310434e-01 0.200 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.310434e-01 0.200 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.313961e-01 0.200 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.377547e-01 0.195 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.390279e-01 0.194 0 0
Signaling by NODAL R-HSA-1181150 6.390279e-01 0.194 0 0
Nephrin family interactions R-HSA-373753 6.390279e-01 0.194 0 0
Signal transduction by L1 R-HSA-445144 6.390279e-01 0.194 0 0
PI3K Cascade R-HSA-109704 6.405541e-01 0.193 0 0
Potassium Channels R-HSA-1296071 6.507089e-01 0.187 0 0
Cam-PDE 1 activation R-HSA-111957 6.512785e-01 0.186 0 0
PKB-mediated events R-HSA-109703 6.512785e-01 0.186 0 0
PDE3B signalling R-HSA-165160 6.512785e-01 0.186 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.512785e-01 0.186 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.512785e-01 0.186 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.512785e-01 0.186 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.512785e-01 0.186 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.512785e-01 0.186 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.512785e-01 0.186 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.512785e-01 0.186 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.512785e-01 0.186 0 0
NGF-independant TRKA activation R-HSA-187024 6.512785e-01 0.186 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.512785e-01 0.186 0 0
Synthesis of PS R-HSA-1483101 6.512785e-01 0.186 0 0
Formation of the Editosome R-HSA-75094 6.512785e-01 0.186 0 0
Phosphorylation of Emi1 R-HSA-176417 6.512785e-01 0.186 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.512785e-01 0.186 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.512785e-01 0.186 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.512785e-01 0.186 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.512785e-01 0.186 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.512785e-01 0.186 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.512785e-01 0.186 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.512785e-01 0.186 0 0
TRAIL signaling R-HSA-75158 6.512785e-01 0.186 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.512785e-01 0.186 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.520796e-01 0.186 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.547754e-01 0.184 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.547754e-01 0.184 0 0
rRNA modification in the mitochondrion R-HSA-6793080 6.547754e-01 0.184 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.551544e-01 0.184 0 0
Triglyceride metabolism R-HSA-8979227 6.551544e-01 0.184 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 6.578310e-01 0.182 0 0
Signaling by SCF-KIT R-HSA-1433557 6.616994e-01 0.179 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.648887e-01 0.177 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.673515e-01 0.176 0 0
HSF1 activation R-HSA-3371511 6.673515e-01 0.176 0 0
RNA Polymerase III Transcription R-HSA-74158 6.673515e-01 0.176 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.673515e-01 0.176 0 0
FLT3 signaling in disease R-HSA-9682385 6.673515e-01 0.176 0 0
RAB geranylgeranylation R-HSA-8873719 6.709843e-01 0.173 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.745596e-01 0.171 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.745973e-01 0.171 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.795811e-01 0.168 0 0
Macroautophagy R-HSA-1632852 6.843105e-01 0.165 0 0
Influenza Infection R-HSA-168255 6.850003e-01 0.164 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.850831e-01 0.164 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.850831e-01 0.164 0 0
Regulation of KIT signaling R-HSA-1433559 6.850831e-01 0.164 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.865906e-01 0.163 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.893722e-01 0.162 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.893722e-01 0.162 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.908404e-01 0.161 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.908404e-01 0.161 0 0
PCP/CE pathway R-HSA-4086400 6.940347e-01 0.159 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.943161e-01 0.158 0 0
STAT5 Activation R-HSA-9645135 6.943161e-01 0.158 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.943161e-01 0.158 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.943161e-01 0.158 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.943161e-01 0.158 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.943161e-01 0.158 0 0
Neurofascin interactions R-HSA-447043 6.943161e-01 0.158 0 0
Hydrolysis of LPE R-HSA-1483152 6.943161e-01 0.158 0 0
Lipid particle organization R-HSA-8964572 6.943161e-01 0.158 0 0
HDL clearance R-HSA-8964011 6.943161e-01 0.158 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.967890e-01 0.157 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.967890e-01 0.157 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.968384e-01 0.157 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.968384e-01 0.157 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.968384e-01 0.157 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.968384e-01 0.157 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.968384e-01 0.157 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.018858e-01 0.154 0 0
MET promotes cell motility R-HSA-8875878 7.050610e-01 0.152 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.050610e-01 0.152 0 0
Translation initiation complex formation R-HSA-72649 7.065508e-01 0.151 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.065508e-01 0.151 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.110431e-01 0.148 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.110431e-01 0.148 0 0
Cilium Assembly R-HSA-5617833 7.114521e-01 0.148 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.115656e-01 0.148 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.124858e-01 0.147 0 0
FGFR2 alternative splicing R-HSA-6803529 7.124858e-01 0.147 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.124858e-01 0.147 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.124858e-01 0.147 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.124858e-01 0.147 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.124858e-01 0.147 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.131708e-01 0.147 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.131708e-01 0.147 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.131708e-01 0.147 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.131708e-01 0.147 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.131708e-01 0.147 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.131708e-01 0.147 0 0
Protein methylation R-HSA-8876725 7.131708e-01 0.147 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.134629e-01 0.147 0 0
Interleukin-12 family signaling R-HSA-447115 7.167340e-01 0.145 0 0
EGFR downregulation R-HSA-182971 7.167356e-01 0.145 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.167356e-01 0.145 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.227575e-01 0.141 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.244549e-01 0.140 0 0
Selective autophagy R-HSA-9663891 7.288282e-01 0.137 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.294495e-01 0.137 0 0
Insulin receptor signalling cascade R-HSA-74751 7.297299e-01 0.137 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.320444e-01 0.135 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.320444e-01 0.135 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.320444e-01 0.135 0 0
Netrin mediated repulsion signals R-HSA-418886 7.320444e-01 0.135 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.320444e-01 0.135 0 0
Disinhibition of SNARE formation R-HSA-114516 7.320444e-01 0.135 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.320444e-01 0.135 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.320444e-01 0.135 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.320444e-01 0.135 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.320444e-01 0.135 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.320444e-01 0.135 0 0
Activation of TRKA receptors R-HSA-187015 7.320444e-01 0.135 0 0
Glycoprotein hormones R-HSA-209822 7.320444e-01 0.135 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.320444e-01 0.135 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.320444e-01 0.135 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.320444e-01 0.135 0 0
Signaling by Hedgehog R-HSA-5358351 7.340381e-01 0.134 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.342481e-01 0.134 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.356979e-01 0.133 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 7.363491e-01 0.133 0 0
Signaling by EGFR R-HSA-177929 7.363491e-01 0.133 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.383470e-01 0.132 0 0
Killing mechanisms R-HSA-9664420 7.391247e-01 0.131 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.391247e-01 0.131 0 0
Regulation of BACH1 activity R-HSA-9708530 7.391247e-01 0.131 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 7.391247e-01 0.131 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.391247e-01 0.131 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 7.391247e-01 0.131 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.396795e-01 0.131 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.396795e-01 0.131 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.396795e-01 0.131 0 0
Diseases of Immune System R-HSA-5260271 7.396795e-01 0.131 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.396795e-01 0.131 0 0
Glycogen metabolism R-HSA-8982491 7.396795e-01 0.131 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.396795e-01 0.131 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.396795e-01 0.131 0 0
GPER1 signaling R-HSA-9634597 7.447969e-01 0.128 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.447969e-01 0.128 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.480675e-01 0.126 0 0
Neutrophil degranulation R-HSA-6798695 7.531717e-01 0.123 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.546876e-01 0.122 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.546876e-01 0.122 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.546876e-01 0.122 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.558309e-01 0.122 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.558309e-01 0.122 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.566307e-01 0.121 0 0
HIV Infection R-HSA-162906 7.567800e-01 0.121 0 0
Phase 2 - plateau phase R-HSA-5576893 7.630436e-01 0.117 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.630436e-01 0.117 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 7.630436e-01 0.117 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.630436e-01 0.117 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 7.630436e-01 0.117 0 0
Passive transport by Aquaporins R-HSA-432047 7.630436e-01 0.117 0 0
Synthesis of PG R-HSA-1483148 7.630436e-01 0.117 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.638597e-01 0.117 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.639691e-01 0.117 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.651180e-01 0.116 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.651180e-01 0.116 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.651180e-01 0.116 0 0
Interleukin-9 signaling R-HSA-8985947 7.651180e-01 0.116 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.651180e-01 0.116 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.651180e-01 0.116 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.651180e-01 0.116 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.651180e-01 0.116 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.651180e-01 0.116 0 0
Nucleotide salvage defects R-HSA-9734207 7.651180e-01 0.116 0 0
HCMV Late Events R-HSA-9610379 7.661244e-01 0.116 0 0
SARS-CoV Infections R-HSA-9679506 7.680246e-01 0.115 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.712194e-01 0.113 0 0
HIV Transcription Initiation R-HSA-167161 7.712194e-01 0.113 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.712194e-01 0.113 0 0
Intra-Golgi traffic R-HSA-6811438 7.712194e-01 0.113 0 0
Vesicle-mediated transport R-HSA-5653656 7.717176e-01 0.113 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.738404e-01 0.111 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.738404e-01 0.111 0 0
Regulation of beta-cell development R-HSA-186712 7.769650e-01 0.110 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.790196e-01 0.108 0 0
Synthesis of DNA R-HSA-69239 7.848848e-01 0.105 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.850344e-01 0.105 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.850344e-01 0.105 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.850344e-01 0.105 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.850344e-01 0.105 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.850344e-01 0.105 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.850344e-01 0.105 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.850344e-01 0.105 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.850344e-01 0.105 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.868049e-01 0.104 0 0
rRNA processing R-HSA-72312 7.908418e-01 0.102 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.917488e-01 0.101 0 0
Metalloprotease DUBs R-HSA-5689901 7.917488e-01 0.101 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.917488e-01 0.101 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.917488e-01 0.101 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.941111e-01 0.100 0 0
Interleukin-21 signaling R-HSA-9020958 7.941111e-01 0.100 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.941111e-01 0.100 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.941111e-01 0.100 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.941111e-01 0.100 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.941111e-01 0.100 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.941111e-01 0.100 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.941111e-01 0.100 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.941111e-01 0.100 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.941111e-01 0.100 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.941111e-01 0.100 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.941111e-01 0.100 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.941111e-01 0.100 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.997545e-01 0.097 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.052085e-01 0.094 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.052085e-01 0.094 0 0
GAB1 signalosome R-HSA-180292 8.052085e-01 0.094 0 0
Mismatch Repair R-HSA-5358508 8.052085e-01 0.094 0 0
Tie2 Signaling R-HSA-210993 8.052085e-01 0.094 0 0
Platelet sensitization by LDL R-HSA-432142 8.052085e-01 0.094 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.052085e-01 0.094 0 0
Ribosome-associated quality control R-HSA-9948299 8.053467e-01 0.094 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.078766e-01 0.093 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.084597e-01 0.092 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.084597e-01 0.092 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.084597e-01 0.092 0 0
Signaling by PDGF R-HSA-186797 8.127574e-01 0.090 0 0
DAP12 interactions R-HSA-2172127 8.129314e-01 0.090 0 0
Hedgehog 'on' state R-HSA-5632684 8.143803e-01 0.089 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.162670e-01 0.088 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.166248e-01 0.088 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.195269e-01 0.086 0 0
DNA replication initiation R-HSA-68952 8.195269e-01 0.086 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.195269e-01 0.086 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.195269e-01 0.086 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.195269e-01 0.086 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.195269e-01 0.086 0 0
Pexophagy R-HSA-9664873 8.195269e-01 0.086 0 0
Maturation of spike protein R-HSA-9683686 8.195269e-01 0.086 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.195269e-01 0.086 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.195269e-01 0.086 0 0
Peptide hormone biosynthesis R-HSA-209952 8.195269e-01 0.086 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.195269e-01 0.086 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.236792e-01 0.084 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.236792e-01 0.084 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.236792e-01 0.084 0 0
Regulation of signaling by CBL R-HSA-912631 8.236792e-01 0.084 0 0
Maturation of nucleoprotein R-HSA-9694631 8.236792e-01 0.084 0 0
Other interleukin signaling R-HSA-449836 8.236792e-01 0.084 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.240236e-01 0.084 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.240236e-01 0.084 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.240236e-01 0.084 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.240236e-01 0.084 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.240236e-01 0.084 0 0
Pyrimidine salvage R-HSA-73614 8.240236e-01 0.084 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.253046e-01 0.083 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.254053e-01 0.083 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.254053e-01 0.083 0 0
Ion channel transport R-HSA-983712 8.255564e-01 0.083 0 0
Developmental Cell Lineages R-HSA-9734767 8.289446e-01 0.081 0 0
Gastrulation R-HSA-9758941 8.316271e-01 0.080 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.317866e-01 0.080 0 0
Cellular response to starvation R-HSA-9711097 8.353717e-01 0.078 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.371964e-01 0.077 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.371964e-01 0.077 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.371964e-01 0.077 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.371964e-01 0.077 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.371964e-01 0.077 0 0
Downstream TCR signaling R-HSA-202424 8.372083e-01 0.077 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 8.384932e-01 0.077 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.384932e-01 0.077 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.384932e-01 0.077 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.405596e-01 0.075 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.405596e-01 0.075 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.418065e-01 0.075 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.418065e-01 0.075 0 0
Interleukin-2 signaling R-HSA-9020558 8.418065e-01 0.075 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.418065e-01 0.075 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.418065e-01 0.075 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.418065e-01 0.075 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.418065e-01 0.075 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.418065e-01 0.075 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.418065e-01 0.075 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.418065e-01 0.075 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.418065e-01 0.075 0 0
Suppression of apoptosis R-HSA-9635465 8.418065e-01 0.075 0 0
Signaling by NOTCH4 R-HSA-9013694 8.437776e-01 0.074 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.456413e-01 0.073 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.482984e-01 0.071 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.483263e-01 0.071 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.519227e-01 0.070 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.519227e-01 0.070 0 0
Immune System R-HSA-168256 8.519685e-01 0.070 0 0
Signaling by ALK R-HSA-201556 8.541040e-01 0.068 0 0
Cellular response to chemical stress R-HSA-9711123 8.544045e-01 0.068 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.559608e-01 0.068 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.559608e-01 0.068 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.559608e-01 0.068 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.559608e-01 0.068 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.559608e-01 0.068 0 0
Lagging Strand Synthesis R-HSA-69186 8.559608e-01 0.068 0 0
Signalling to RAS R-HSA-167044 8.559608e-01 0.068 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.559608e-01 0.068 0 0
Basigin interactions R-HSA-210991 8.559608e-01 0.068 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.559608e-01 0.068 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.559608e-01 0.068 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.613368e-01 0.065 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.613368e-01 0.065 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.613368e-01 0.065 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.613368e-01 0.065 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.613368e-01 0.065 0 0
Sodium/Calcium exchangers R-HSA-425561 8.613368e-01 0.065 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.613368e-01 0.065 0 0
Kidney development R-HSA-9830369 8.623059e-01 0.064 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.643671e-01 0.063 0 0
Budding and maturation of HIV virion R-HSA-162588 8.643671e-01 0.063 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.646077e-01 0.063 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.651511e-01 0.063 0 0
Host Interactions of HIV factors R-HSA-162909 8.668411e-01 0.062 0 0
Degradation of CDH1 R-HSA-9766229 8.686953e-01 0.061 0 0
PPARA activates gene expression R-HSA-1989781 8.691821e-01 0.061 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.699907e-01 0.060 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.699907e-01 0.060 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.699907e-01 0.060 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.699907e-01 0.060 0 0
Transmission across Chemical Synapses R-HSA-112315 8.772293e-01 0.057 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.779822e-01 0.057 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.779822e-01 0.057 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.784570e-01 0.056 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.784570e-01 0.056 0 0
MET activates RAS signaling R-HSA-8851805 8.784570e-01 0.056 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.784570e-01 0.056 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.784570e-01 0.056 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.784570e-01 0.056 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.784570e-01 0.056 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.784570e-01 0.056 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.784570e-01 0.056 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.784570e-01 0.056 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.784570e-01 0.056 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.801421e-01 0.055 0 0
GABA receptor activation R-HSA-977443 8.819044e-01 0.055 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.827530e-01 0.054 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.827530e-01 0.054 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.827530e-01 0.054 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.827530e-01 0.054 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.827530e-01 0.054 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.840373e-01 0.054 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.851029e-01 0.053 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.851029e-01 0.053 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.851029e-01 0.053 0 0
HCMV Infection R-HSA-9609646 8.860521e-01 0.053 0 0
COPII-mediated vesicle transport R-HSA-204005 8.865076e-01 0.052 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.865193e-01 0.052 0 0
The phototransduction cascade R-HSA-2514856 8.867034e-01 0.052 0 0
Inositol phosphate metabolism R-HSA-1483249 8.892379e-01 0.051 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.898297e-01 0.051 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.898297e-01 0.051 0 0
Interferon gamma signaling R-HSA-877300 8.903648e-01 0.050 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.934642e-01 0.049 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.934642e-01 0.049 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.934642e-01 0.049 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.934642e-01 0.049 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.934642e-01 0.049 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.934642e-01 0.049 0 0
Chylomicron remodeling R-HSA-8963901 8.934642e-01 0.049 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.934642e-01 0.049 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.934642e-01 0.049 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.934642e-01 0.049 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.934642e-01 0.049 0 0
Diseases of nucleotide metabolism R-HSA-9735804 8.934642e-01 0.049 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.934642e-01 0.049 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.934642e-01 0.049 0 0
Maturation of nucleoprotein R-HSA-9683610 8.934642e-01 0.049 0 0
Formation of the ureteric bud R-HSA-9830674 8.943467e-01 0.048 0 0
Growth hormone receptor signaling R-HSA-982772 8.943467e-01 0.048 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.948838e-01 0.048 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.963347e-01 0.048 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.963347e-01 0.048 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.972981e-01 0.047 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.986505e-01 0.046 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.006246e-01 0.045 0 0
Nucleotide Excision Repair R-HSA-5696398 9.006929e-01 0.045 0 0
Signaling by FGFR4 R-HSA-5654743 9.024297e-01 0.045 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.024297e-01 0.045 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.025482e-01 0.045 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.048659e-01 0.043 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.048659e-01 0.043 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.048659e-01 0.043 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.053793e-01 0.043 0 0
Platelet homeostasis R-HSA-418346 9.061286e-01 0.043 0 0
Removal of the Flap Intermediate R-HSA-69166 9.066193e-01 0.043 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.066193e-01 0.043 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.066193e-01 0.043 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.066193e-01 0.043 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.066193e-01 0.043 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.066193e-01 0.043 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.066193e-01 0.043 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.066193e-01 0.043 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.066193e-01 0.043 0 0
Prolactin receptor signaling R-HSA-1170546 9.066193e-01 0.043 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 9.066193e-01 0.043 0 0
Hydrolysis of LPC R-HSA-1483115 9.066193e-01 0.043 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.066193e-01 0.043 0 0
Malate-aspartate shuttle R-HSA-9856872 9.066193e-01 0.043 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.066193e-01 0.043 0 0
Ciprofloxacin ADME R-HSA-9793528 9.066193e-01 0.043 0 0
Signal regulatory protein family interactions R-HSA-391160 9.066193e-01 0.043 0 0
Zinc transporters R-HSA-435354 9.066193e-01 0.043 0 0
P2Y receptors R-HSA-417957 9.066193e-01 0.043 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.078189e-01 0.042 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.094727e-01 0.041 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.102552e-01 0.041 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.137035e-01 0.039 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.137035e-01 0.039 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.143991e-01 0.039 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.143991e-01 0.039 0 0
G protein gated Potassium channels R-HSA-1296059 9.143991e-01 0.039 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.143991e-01 0.039 0 0
Hyaluronan degradation R-HSA-2160916 9.143991e-01 0.039 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.157451e-01 0.038 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.158854e-01 0.038 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.164273e-01 0.038 0 0
Cellular response to hypoxia R-HSA-1234174 9.171520e-01 0.038 0 0
Signaling by FGFR3 R-HSA-5654741 9.174042e-01 0.037 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.181506e-01 0.037 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.181506e-01 0.037 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.181506e-01 0.037 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.181506e-01 0.037 0 0
Processive synthesis on the lagging strand R-HSA-69183 9.181506e-01 0.037 0 0
Translesion synthesis by REV1 R-HSA-110312 9.181506e-01 0.037 0 0
Protein lipoylation R-HSA-9857492 9.181506e-01 0.037 0 0
Signaling by Activin R-HSA-1502540 9.181506e-01 0.037 0 0
p38MAPK events R-HSA-171007 9.181506e-01 0.037 0 0
Biotin transport and metabolism R-HSA-196780 9.181506e-01 0.037 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.181506e-01 0.037 0 0
Events associated with phagocytolytic activity of PMN cells R-HSA-8941413 9.181506e-01 0.037 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.181506e-01 0.037 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.181506e-01 0.037 0 0
DNA Damage Reversal R-HSA-73942 9.181506e-01 0.037 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.188819e-01 0.037 0 0
Signaling by Insulin receptor R-HSA-74752 9.189497e-01 0.037 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.213557e-01 0.036 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.213557e-01 0.036 0 0
Glycosphingolipid transport R-HSA-9845576 9.213557e-01 0.036 0 0
RUNX2 regulates bone development R-HSA-8941326 9.213557e-01 0.036 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.226902e-01 0.035 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.230293e-01 0.035 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.230293e-01 0.035 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.230293e-01 0.035 0 0
Abacavir ADME R-HSA-2161522 9.230293e-01 0.035 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.230293e-01 0.035 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.240916e-01 0.034 0 0
Translesion synthesis by POLI R-HSA-5656121 9.282585e-01 0.032 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.282585e-01 0.032 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.282585e-01 0.032 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.282585e-01 0.032 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.282585e-01 0.032 0 0
Activation of SMO R-HSA-5635838 9.282585e-01 0.032 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.282585e-01 0.032 0 0
Fructose catabolism R-HSA-70350 9.282585e-01 0.032 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.282585e-01 0.032 0 0
Negative regulation of FLT3 R-HSA-9706369 9.282585e-01 0.032 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.282585e-01 0.032 0 0
Atorvastatin ADME R-HSA-9754706 9.282585e-01 0.032 0 0
Degradation of DVL R-HSA-4641258 9.283822e-01 0.032 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.283822e-01 0.032 0 0
Regulation of CDH1 Function R-HSA-9764561 9.285334e-01 0.032 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.308341e-01 0.031 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.308341e-01 0.031 0 0
Triglyceride biosynthesis R-HSA-75109 9.308341e-01 0.031 0 0
Synthesis of PE R-HSA-1483213 9.308341e-01 0.031 0 0
Signaling by BMP R-HSA-201451 9.308341e-01 0.031 0 0
Insulin processing R-HSA-264876 9.308341e-01 0.031 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.309918e-01 0.031 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.311941e-01 0.031 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.335710e-01 0.030 0 0
Dual incision in TC-NER R-HSA-6782135 9.339799e-01 0.030 0 0
Translesion synthesis by POLK R-HSA-5655862 9.371187e-01 0.028 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.371187e-01 0.028 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.371187e-01 0.028 0 0
Glycine degradation R-HSA-6783984 9.371187e-01 0.028 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.371187e-01 0.028 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.371187e-01 0.028 0 0
Coenzyme A biosynthesis R-HSA-196783 9.371187e-01 0.028 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.378858e-01 0.028 0 0
RSV-host interactions R-HSA-9833110 9.391415e-01 0.027 0 0
Stabilization of p53 R-HSA-69541 9.407332e-01 0.027 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.407332e-01 0.027 0 0
DNA Damage Bypass R-HSA-73893 9.413266e-01 0.026 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.418222e-01 0.026 0 0
PKR-mediated signaling R-HSA-9833482 9.429307e-01 0.026 0 0
Signaling by FGFR2 R-HSA-5654738 9.429307e-01 0.026 0 0
Selenoamino acid metabolism R-HSA-2408522 9.438711e-01 0.025 0 0
mRNA Capping R-HSA-72086 9.442512e-01 0.025 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.442512e-01 0.025 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.442512e-01 0.025 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.448851e-01 0.025 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.448851e-01 0.025 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.448851e-01 0.025 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.448851e-01 0.025 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.448851e-01 0.025 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.448851e-01 0.025 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.448851e-01 0.025 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.448851e-01 0.025 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.448851e-01 0.025 0 0
Choline catabolism R-HSA-6798163 9.448851e-01 0.025 0 0
Phospholipid metabolism R-HSA-1483257 9.458425e-01 0.024 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.461397e-01 0.024 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.470385e-01 0.024 0 0
Nucleotide salvage R-HSA-8956321 9.481563e-01 0.023 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.499922e-01 0.022 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.499922e-01 0.022 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.510844e-01 0.022 0 0
Maturation of spike protein R-HSA-9694548 9.510844e-01 0.022 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.510844e-01 0.022 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.516927e-01 0.022 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.516927e-01 0.022 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.516927e-01 0.022 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.516927e-01 0.022 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.516927e-01 0.022 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.516927e-01 0.022 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.516927e-01 0.022 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.516927e-01 0.022 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.522299e-01 0.021 0 0
tRNA processing in the nucleus R-HSA-6784531 9.522299e-01 0.021 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.535310e-01 0.021 0 0
Viral Infection Pathways R-HSA-9824446 9.535417e-01 0.021 0 0
IRE1alpha activates chaperones R-HSA-381070 9.542588e-01 0.020 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.551660e-01 0.020 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.551660e-01 0.020 0 0
Cargo concentration in the ER R-HSA-5694530 9.551660e-01 0.020 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.551660e-01 0.020 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.556026e-01 0.020 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.562537e-01 0.019 0 0
Neddylation R-HSA-8951664 9.563896e-01 0.019 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.573692e-01 0.019 0 0
Translesion Synthesis by POLH R-HSA-110320 9.576597e-01 0.019 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.576597e-01 0.019 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.576597e-01 0.019 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.576597e-01 0.019 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.587606e-01 0.018 0 0
Activation of GABAB receptors R-HSA-991365 9.597277e-01 0.018 0 0
GABA B receptor activation R-HSA-977444 9.597277e-01 0.018 0 0
Iron uptake and transport R-HSA-917937 9.611706e-01 0.017 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.622979e-01 0.017 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.628900e-01 0.016 0 0
Pregnenolone biosynthesis R-HSA-196108 9.628900e-01 0.016 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.632815e-01 0.016 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.640176e-01 0.016 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.640176e-01 0.016 0 0
UCH proteinases R-HSA-5689603 9.641202e-01 0.016 0 0
G alpha (z) signalling events R-HSA-418597 9.655517e-01 0.015 0 0
Signaling by NOTCH3 R-HSA-9012852 9.655517e-01 0.015 0 0
Surfactant metabolism R-HSA-5683826 9.669207e-01 0.015 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.674745e-01 0.014 0 0
G-protein activation R-HSA-202040 9.674745e-01 0.014 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.674745e-01 0.014 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.674745e-01 0.014 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.674745e-01 0.014 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.674745e-01 0.014 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.677877e-01 0.014 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.677877e-01 0.014 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.677877e-01 0.014 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.677877e-01 0.014 0 0
Heme degradation R-HSA-189483 9.677877e-01 0.014 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.684363e-01 0.014 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.685425e-01 0.014 0 0
Signaling by FGFR1 R-HSA-5654736 9.685425e-01 0.014 0 0
Integrin cell surface interactions R-HSA-216083 9.694137e-01 0.013 0 0
Dual Incision in GG-NER R-HSA-5696400 9.711757e-01 0.013 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.711757e-01 0.013 0 0
eNOS activation R-HSA-203615 9.711757e-01 0.013 0 0
Hyaluronan metabolism R-HSA-2142845 9.711757e-01 0.013 0 0
Signaling by NOTCH2 R-HSA-1980145 9.711757e-01 0.013 0 0
Mitophagy R-HSA-5205647 9.711757e-01 0.013 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.714929e-01 0.013 0 0
Attachment and Entry R-HSA-9694614 9.714929e-01 0.013 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.714929e-01 0.013 0 0
Assembly Of The HIV Virion R-HSA-175474 9.714929e-01 0.013 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.728881e-01 0.012 0 0
Signaling by MET R-HSA-6806834 9.739806e-01 0.011 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.740819e-01 0.011 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.742186e-01 0.011 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.742186e-01 0.011 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.742186e-01 0.011 0 0
Oncogene Induced Senescence R-HSA-2559585 9.742186e-01 0.011 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.742186e-01 0.011 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.750150e-01 0.011 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.750150e-01 0.011 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.750150e-01 0.011 0 0
LDL clearance R-HSA-8964038 9.750150e-01 0.011 0 0
Fructose metabolism R-HSA-5652084 9.750150e-01 0.011 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.750150e-01 0.011 0 0
Signaling by KIT in disease R-HSA-9669938 9.750150e-01 0.011 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.750150e-01 0.011 0 0
Interferon Signaling R-HSA-913531 9.754140e-01 0.011 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.754741e-01 0.011 0 0
Synthesis of PC R-HSA-1483191 9.754741e-01 0.011 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.761229e-01 0.010 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.772152e-01 0.010 0 0
Intraflagellar transport R-HSA-5620924 9.778245e-01 0.010 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.781021e-01 0.010 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.781021e-01 0.010 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.781021e-01 0.010 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.781021e-01 0.010 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.781021e-01 0.010 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.781021e-01 0.010 0 0
Carnitine shuttle R-HSA-200425 9.781021e-01 0.010 0 0
Biosynthesis of maresins R-HSA-9018682 9.781021e-01 0.010 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.782421e-01 0.010 0 0
Leishmania infection R-HSA-9658195 9.788081e-01 0.009 0 0
Parasitic Infection Pathways R-HSA-9824443 9.788081e-01 0.009 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.793998e-01 0.009 0 0
Voltage gated Potassium channels R-HSA-1296072 9.793998e-01 0.009 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.793998e-01 0.009 0 0
Degradation of AXIN R-HSA-4641257 9.793998e-01 0.009 0 0
Lysine catabolism R-HSA-71064 9.793998e-01 0.009 0 0
Collagen chain trimerization R-HSA-8948216 9.793998e-01 0.009 0 0
G alpha (q) signalling events R-HSA-416476 9.799196e-01 0.009 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.801832e-01 0.009 0 0
Collagen degradation R-HSA-1442490 9.801832e-01 0.009 0 0
Protein folding R-HSA-391251 9.801879e-01 0.009 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.808079e-01 0.008 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.808079e-01 0.008 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.808079e-01 0.008 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.808079e-01 0.008 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.815965e-01 0.008 0 0
Elastic fibre formation R-HSA-1566948 9.815965e-01 0.008 0 0
Purine salvage R-HSA-74217 9.815965e-01 0.008 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.819599e-01 0.008 0 0
Mitochondrial protein import R-HSA-1268020 9.819599e-01 0.008 0 0
Mitochondrial protein degradation R-HSA-9837999 9.831002e-01 0.007 0 0
Collagen formation R-HSA-1474290 9.831002e-01 0.007 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.831796e-01 0.007 0 0
Laminin interactions R-HSA-3000157 9.831796e-01 0.007 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.831796e-01 0.007 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.831796e-01 0.007 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.835650e-01 0.007 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.835650e-01 0.007 0 0
RAS processing R-HSA-9648002 9.835650e-01 0.007 0 0
SLC transporter disorders R-HSA-5619102 9.836491e-01 0.007 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.836549e-01 0.007 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.843259e-01 0.007 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.843259e-01 0.007 0 0
Ion transport by P-type ATPases R-HSA-936837 9.850708e-01 0.007 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.852485e-01 0.006 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.852485e-01 0.006 0 0
MET activates PTK2 signaling R-HSA-8874081 9.852582e-01 0.006 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.852582e-01 0.006 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.852582e-01 0.006 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.852582e-01 0.006 0 0
Sphingolipid catabolism R-HSA-9845614 9.852582e-01 0.006 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.853282e-01 0.006 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.865697e-01 0.006 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.866925e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9694635 9.868934e-01 0.006 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.869068e-01 0.006 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.870801e-01 0.006 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.870801e-01 0.006 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.870801e-01 0.006 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.870801e-01 0.006 0 0
Translation of Structural Proteins R-HSA-9683701 9.883194e-01 0.005 0 0
Prednisone ADME R-HSA-9757110 9.886770e-01 0.005 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.886770e-01 0.005 0 0
Insulin receptor recycling R-HSA-77387 9.886770e-01 0.005 0 0
Signaling by FGFR R-HSA-190236 9.887299e-01 0.005 0 0
ER-Phagosome pathway R-HSA-1236974 9.887373e-01 0.005 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.887988e-01 0.005 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.889394e-01 0.005 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.891837e-01 0.005 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.895829e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.898304e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.900765e-01 0.004 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.900765e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.900765e-01 0.004 0 0
Glucagon-type ligand receptors R-HSA-420092 9.900765e-01 0.004 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.900765e-01 0.004 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.900765e-01 0.004 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.902544e-01 0.004 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.902544e-01 0.004 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.907126e-01 0.004 0 0
Defensins R-HSA-1461973 9.907126e-01 0.004 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.913032e-01 0.004 0 0
Gap junction trafficking R-HSA-190828 9.917223e-01 0.004 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.920409e-01 0.003 0 0
Hemostasis R-HSA-109582 9.921329e-01 0.003 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.923782e-01 0.003 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.923782e-01 0.003 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.923782e-01 0.003 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.923782e-01 0.003 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.926243e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.926243e-01 0.003 0 0
Leishmania phagocytosis R-HSA-9664417 9.927056e-01 0.003 0 0
Parasite infection R-HSA-9664407 9.927056e-01 0.003 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.927056e-01 0.003 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.928877e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.933205e-01 0.003 0 0
HS-GAG degradation R-HSA-2024096 9.933205e-01 0.003 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.934299e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.936012e-01 0.003 0 0
Recycling of bile acids and salts R-HSA-159418 9.941463e-01 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.943524e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.946453e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.947910e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.949639e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.950933e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.951995e-01 0.002 0 0
Gap junction trafficking and regulation R-HSA-157858 9.953636e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.954608e-01 0.002 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.955043e-01 0.002 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.955043e-01 0.002 0 0
Gap junction assembly R-HSA-190861 9.955043e-01 0.002 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.955043e-01 0.002 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.955043e-01 0.002 0 0
Signal amplification R-HSA-392518 9.955043e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.955043e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.955043e-01 0.002 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.955043e-01 0.002 0 0
PERK regulates gene expression R-HSA-381042 9.960602e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.960602e-01 0.002 0 0
Regulation of Apoptosis R-HSA-169911 9.960602e-01 0.002 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.960602e-01 0.002 0 0
ABC transporter disorders R-HSA-5619084 9.962124e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.962124e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.962124e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.963296e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.964217e-01 0.002 0 0
HS-GAG biosynthesis R-HSA-2022928 9.965474e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.965754e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.966305e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.969744e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.969744e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.969744e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.969754e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.970336e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.972160e-01 0.001 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.974358e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.974811e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.976765e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.976765e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.976765e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.976970e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.978161e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.980419e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.980419e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.981888e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.981888e-01 0.001 0 0
Platelet degranulation R-HSA-114608 9.982136e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.982157e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.982157e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.984365e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.984875e-01 0.001 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.985705e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.985711e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.986299e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.986429e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.986626e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.986685e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.987312e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.987994e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.987994e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.989479e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.989479e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.989479e-01 0.000 0 0
Protein localization R-HSA-9609507 9.989535e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.989706e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.990781e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.990781e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.992922e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.993407e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.993798e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.994504e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.994504e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.994565e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.994565e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.994565e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.995127e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.995238e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.995827e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.996605e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.996605e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.996605e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.996796e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.996864e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996991e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.996994e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.997200e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.997540e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.997791e-01 0.000 0 0
Digestion R-HSA-8935690 9.997845e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.997899e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.998234e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.998272e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.998272e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998367e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.998550e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.998730e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.998887e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998991e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999146e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999146e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999159e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999239e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999252e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999259e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999315e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999344e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999489e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999572e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999621e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.999740e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999769e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999772e-01 0.000 0 0
Translation R-HSA-72766 9.999831e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999859e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999890e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999914e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999921e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999924e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999947e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999954e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999964e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999971e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999976e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999981e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999982e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999983e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999987e-01 0.000 0 0
Disease R-HSA-1643685 9.999987e-01 0.000 1 0
Peptide ligand-binding receptors R-HSA-375276 9.999988e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999994e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999997e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999997e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 2.200240e-12 11.658 0 0
Cell Cycle R-HSA-1640170 5.525691e-12 11.258 0 0
Cellular response to heat stress R-HSA-3371556 1.529699e-11 10.815 0 0
Nervous system development R-HSA-9675108 1.594924e-11 10.797 0 0
Cellular responses to stress R-HSA-2262752 1.617173e-11 10.791 0 0
Cellular responses to stimuli R-HSA-8953897 1.743716e-11 10.759 0 0
Cell Cycle, Mitotic R-HSA-69278 2.249156e-11 10.648 0 0
M Phase R-HSA-68886 6.815970e-11 10.166 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.507017e-11 10.125 0 0
Cell-Cell communication R-HSA-1500931 2.904067e-10 9.537 0 0
Attenuation phase R-HSA-3371568 5.317100e-10 9.274 0 0
Apoptotic execution phase R-HSA-75153 1.867468e-09 8.729 0 0
HSF1-dependent transactivation R-HSA-3371571 2.653822e-09 8.576 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.518890e-09 8.599 1 0
Cell Cycle Checkpoints R-HSA-69620 8.718753e-09 8.060 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.311954e-08 7.882 0 0
Cell junction organization R-HSA-446728 2.498519e-08 7.602 0 0
HSF1 activation R-HSA-3371511 5.115724e-08 7.291 0 0
Metabolism of RNA R-HSA-8953854 6.797288e-08 7.168 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.601689e-08 7.018 0 0
Mitotic Prometaphase R-HSA-68877 1.918373e-07 6.717 0 0
Mitotic Prophase R-HSA-68875 2.119329e-07 6.674 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.681108e-07 6.434 0 0
mRNA Splicing R-HSA-72172 4.431700e-07 6.353 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.134986e-07 6.289 0 0
Kinesins R-HSA-983189 5.783822e-07 6.238 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.862975e-07 6.163 0 0
Signaling by ROBO receptors R-HSA-376176 7.487165e-07 6.126 0 0
Signal Transduction R-HSA-162582 8.372566e-07 6.077 1 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.913914e-07 6.004 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.053712e-06 5.977 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.128909e-06 5.947 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.430827e-06 5.844 0 0
Nucleosome assembly R-HSA-774815 1.430827e-06 5.844 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.608105e-06 5.794 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.608105e-06 5.794 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.828386e-06 5.738 0 0
Signaling by ALK in cancer R-HSA-9700206 1.828386e-06 5.738 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.037994e-06 5.691 0 0
G2/M Checkpoints R-HSA-69481 2.139943e-06 5.670 0 0
Apoptosis R-HSA-109581 3.523392e-06 5.453 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.960296e-06 5.402 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.622850e-06 5.179 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.535419e-06 5.185 0 0
Cell-cell junction organization R-HSA-421270 6.264668e-06 5.203 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.151004e-05 4.939 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.202336e-05 4.920 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.406643e-05 4.852 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.622822e-05 4.790 0 0
Mitotic Anaphase R-HSA-68882 1.725110e-05 4.763 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.788900e-05 4.747 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.876949e-05 4.727 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.921469e-05 4.716 0 0
Programmed Cell Death R-HSA-5357801 2.062925e-05 4.686 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.184450e-05 4.661 0 0
Adherens junctions interactions R-HSA-418990 2.138254e-05 4.670 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.400629e-05 4.620 0 0
Recycling pathway of L1 R-HSA-437239 2.862235e-05 4.543 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.875220e-05 4.541 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.875220e-05 4.541 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.384749e-05 4.470 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.667852e-05 4.436 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.042010e-05 4.393 1 1
Factors involved in megakaryocyte development and platelet production R-HSA-983231 4.345766e-05 4.362 0 0
PKR-mediated signaling R-HSA-9833482 4.349956e-05 4.362 0 0
Separation of Sister Chromatids R-HSA-2467813 4.568536e-05 4.340 0 0
Membrane Trafficking R-HSA-199991 4.389240e-05 4.358 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.408632e-05 4.267 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.505766e-05 4.259 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.666860e-05 4.247 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.235270e-05 4.141 0 0
MHC class II antigen presentation R-HSA-2132295 7.209258e-05 4.142 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.235270e-05 4.141 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.850508e-05 4.105 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.946805e-05 4.100 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.301753e-05 4.081 0 0
mRNA 3'-end processing R-HSA-72187 8.850958e-05 4.053 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.323221e-05 4.030 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.031355e-04 3.987 0 0
Meiotic synapsis R-HSA-1221632 1.091199e-04 3.962 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.158605e-04 3.936 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.393814e-04 3.856 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.393814e-04 3.856 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.390525e-04 3.857 0 0
ESR-mediated signaling R-HSA-8939211 1.387280e-04 3.858 0 0
G2/M Transition R-HSA-69275 1.428849e-04 3.845 0 0
HDACs deacetylate histones R-HSA-3214815 1.633846e-04 3.787 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.750244e-04 3.757 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.862355e-04 3.730 0 0
Nephrin family interactions R-HSA-373753 1.805052e-04 3.744 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.979577e-04 3.703 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.068146e-04 3.684 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.090200e-04 3.680 0 0
Signaling by VEGF R-HSA-194138 2.296281e-04 3.639 0 0
DNA methylation R-HSA-5334118 2.516949e-04 3.599 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.454751e-04 3.610 0 0
Influenza Infection R-HSA-168255 2.599865e-04 3.585 0 0
Semaphorin interactions R-HSA-373755 2.674600e-04 3.573 0 0
MTOR signalling R-HSA-165159 2.741820e-04 3.562 0 0
Cellular Senescence R-HSA-2559583 2.871706e-04 3.542 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.094756e-04 3.509 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.264630e-04 3.486 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.437296e-04 3.464 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.464384e-04 3.460 0 0
Ephrin signaling R-HSA-3928664 3.827897e-04 3.417 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.846555e-04 3.415 0 0
Chromatin organization R-HSA-4839726 3.910970e-04 3.408 0 0
EPH-Ephrin signaling R-HSA-2682334 3.966066e-04 3.402 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.966066e-04 3.402 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.304692e-04 3.366 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.086104e-04 3.294 0 0
Packaging Of Telomere Ends R-HSA-171306 5.144932e-04 3.289 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.144932e-04 3.289 0 0
DNA Double Strand Break Response R-HSA-5693606 5.267290e-04 3.278 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.268612e-04 3.278 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.436684e-04 3.265 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.823029e-04 3.235 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.453112e-04 3.263 0 0
Chromatin modifying enzymes R-HSA-3247509 6.091378e-04 3.215 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.209841e-04 3.207 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.869651e-04 3.163 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.869651e-04 3.163 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.804746e-04 3.167 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 6.530591e-04 3.185 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 6.530591e-04 3.185 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.394927e-04 3.194 0 0
Regulation of CDH1 Function R-HSA-9764561 6.394927e-04 3.194 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.644216e-04 3.178 0 0
L1CAM interactions R-HSA-373760 6.376517e-04 3.195 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.654821e-04 3.116 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.735576e-04 3.112 0 0
Smooth Muscle Contraction R-HSA-445355 8.318268e-04 3.080 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.374719e-04 3.077 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.374719e-04 3.077 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.484790e-04 3.071 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.539015e-04 3.069 0 0
Striated Muscle Contraction R-HSA-390522 8.568222e-04 3.067 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.681416e-04 3.061 0 0
Post NMDA receptor activation events R-HSA-438064 8.892372e-04 3.051 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.027689e-03 2.988 0 0
Peptide chain elongation R-HSA-156902 1.016141e-03 2.993 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.782293e-04 3.010 0 0
Signaling by ERBB2 R-HSA-1227986 1.054972e-03 2.977 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.066691e-03 2.972 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.078044e-03 2.967 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.103546e-03 2.957 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.103546e-03 2.957 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.120691e-03 2.951 0 0
Chromosome Maintenance R-HSA-73886 1.122132e-03 2.950 0 0
RNA Polymerase I Transcription R-HSA-73864 1.155076e-03 2.937 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.155076e-03 2.937 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.253674e-03 2.902 0 0
Hedgehog 'off' state R-HSA-5610787 1.272396e-03 2.895 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.277275e-03 2.894 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.161833e-03 2.935 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.312561e-03 2.882 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.317851e-03 2.880 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.365380e-03 2.865 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.512652e-03 2.820 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.512652e-03 2.820 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.514420e-03 2.820 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.519815e-03 2.818 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.611323e-03 2.793 0 0
Homology Directed Repair R-HSA-5693538 1.614617e-03 2.792 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.737695e-03 2.760 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.737695e-03 2.760 0 0
mTORC1-mediated signalling R-HSA-166208 1.659520e-03 2.780 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.804984e-03 2.744 0 0
Centrosome maturation R-HSA-380287 1.735867e-03 2.760 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.692339e-03 2.772 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.819426e-03 2.740 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.684564e-03 2.774 0 0
S Phase R-HSA-69242 1.858738e-03 2.731 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.968720e-03 2.706 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.987667e-03 2.702 0 0
Regulation of signaling by CBL R-HSA-912631 2.012210e-03 2.696 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.079530e-03 2.682 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.133482e-03 2.671 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.143751e-03 2.669 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.194329e-03 2.659 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.427256e-03 2.615 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.427256e-03 2.615 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.547185e-03 2.594 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.805801e-03 2.552 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.720575e-03 2.565 0 0
Meiosis R-HSA-1500620 2.878795e-03 2.541 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.626399e-03 2.581 0 0
Defective pyroptosis R-HSA-9710421 2.614656e-03 2.583 0 0
Glycolysis R-HSA-70171 2.626399e-03 2.581 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.894405e-03 2.538 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.047517e-03 2.516 0 0
Gene Silencing by RNA R-HSA-211000 3.128607e-03 2.505 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.306226e-03 2.481 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.393702e-03 2.469 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.406934e-03 2.468 0 0
Aggrephagy R-HSA-9646399 3.422870e-03 2.466 0 0
HCMV Early Events R-HSA-9609690 3.679680e-03 2.434 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.724797e-03 2.429 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.757884e-03 2.425 0 0
Meiotic recombination R-HSA-912446 3.804764e-03 2.420 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.839836e-03 2.416 0 0
Signaling by PTK6 R-HSA-8848021 3.912965e-03 2.407 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.912965e-03 2.407 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.989392e-03 2.399 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.067042e-03 2.391 0 0
Signaling by Hippo R-HSA-2028269 4.190746e-03 2.378 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.191596e-03 2.378 0 0
Ribosome-associated quality control R-HSA-9948299 4.203292e-03 2.376 0 0
RET signaling R-HSA-8853659 4.484280e-03 2.348 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.049318e-03 2.297 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.343701e-03 2.272 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.026841e-03 2.299 0 0
Cleavage of the damaged purine R-HSA-110331 5.343701e-03 2.272 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.648489e-03 2.248 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.648489e-03 2.248 0 0
Depyrimidination R-HSA-73928 5.648489e-03 2.248 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.673487e-03 2.246 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.827578e-03 2.235 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.879221e-03 2.231 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.980978e-03 2.223 0 0
Depurination R-HSA-73927 6.329184e-03 2.199 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.384862e-03 2.195 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.390802e-03 2.194 0 0
Autophagy R-HSA-9612973 6.564057e-03 2.183 0 0
G1/S Transition R-HSA-69206 6.640805e-03 2.178 0 0
DCC mediated attractive signaling R-HSA-418885 6.699695e-03 2.174 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.699695e-03 2.174 0 0
Gap junction trafficking and regulation R-HSA-157858 6.741657e-03 2.171 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.811208e-03 2.167 1 0
Signaling by WNT R-HSA-195721 6.945372e-03 2.158 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.960411e-03 2.157 0 0
Deubiquitination R-HSA-5688426 7.302883e-03 2.137 0 0
Muscle contraction R-HSA-397014 7.421458e-03 2.130 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.686422e-03 2.114 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.680176e-03 2.061 0 0
Nuclear import of Rev protein R-HSA-180746 8.350022e-03 2.078 0 0
Gap junction trafficking R-HSA-190828 7.686422e-03 2.114 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.452957e-03 2.128 0 0
Developmental Biology R-HSA-1266738 8.347337e-03 2.078 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.597201e-03 2.066 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.686422e-03 2.114 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.742155e-03 2.111 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 8.711278e-03 2.060 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.711278e-03 2.060 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.727630e-03 2.059 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.861584e-03 2.052 0 0
Ub-specific processing proteases R-HSA-5689880 8.881384e-03 2.052 0 0
DNA Replication R-HSA-69306 8.897362e-03 2.051 0 0
Formation of annular gap junctions R-HSA-196025 9.059474e-03 2.043 0 0
HATs acetylate histones R-HSA-3214847 9.071343e-03 2.042 0 0
Diseases of programmed cell death R-HSA-9645723 9.182311e-03 2.037 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 9.262154e-03 2.033 0 0
Activation of BH3-only proteins R-HSA-114452 9.262154e-03 2.033 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.435257e-03 2.025 0 0
Host Interactions of HIV factors R-HSA-162909 1.001872e-02 1.999 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.012522e-02 1.995 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.012522e-02 1.995 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.016612e-02 1.993 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.028448e-02 1.988 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.073451e-02 1.969 1 0
Cilium Assembly R-HSA-5617833 1.077012e-02 1.968 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.113181e-02 1.953 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.113181e-02 1.953 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.113181e-02 1.953 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.113181e-02 1.953 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.113181e-02 1.953 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.113181e-02 1.953 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.113181e-02 1.953 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.113181e-02 1.953 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.113181e-02 1.953 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.113181e-02 1.953 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.113181e-02 1.953 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.113181e-02 1.953 0 0
Gap junction degradation R-HSA-190873 1.277814e-02 1.894 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.277814e-02 1.894 0 0
ALK mutants bind TKIs R-HSA-9700645 1.277814e-02 1.894 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.103794e-02 1.957 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.103794e-02 1.957 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.103794e-02 1.957 0 0
Metabolism of non-coding RNA R-HSA-194441 1.134796e-02 1.945 0 0
snRNP Assembly R-HSA-191859 1.134796e-02 1.945 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.099029e-02 1.959 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.195993e-02 1.922 0 0
Eukaryotic Translation Termination R-HSA-72764 1.166246e-02 1.933 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.146480e-02 1.941 0 0
Selenocysteine synthesis R-HSA-2408557 1.095912e-02 1.960 0 0
Base Excision Repair R-HSA-73884 1.123552e-02 1.949 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.099029e-02 1.959 0 0
Viral mRNA Translation R-HSA-192823 1.315033e-02 1.881 0 0
Translation initiation complex formation R-HSA-72649 1.319423e-02 1.880 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.320735e-02 1.879 1 0
Signaling by PDGFR in disease R-HSA-9671555 1.329349e-02 1.876 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.347101e-02 1.871 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.396017e-02 1.855 0 0
Regulation of TP53 Activity R-HSA-5633007 1.479015e-02 1.830 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.534892e-02 1.814 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.534892e-02 1.814 0 0
Cardiogenesis R-HSA-9733709 1.534892e-02 1.814 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.542746e-02 1.812 0 0
Viral Infection Pathways R-HSA-9824446 1.568974e-02 1.804 0 0
Macroautophagy R-HSA-1632852 1.616195e-02 1.792 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.682217e-02 1.774 0 0
Signaling by NTRKs R-HSA-166520 1.726249e-02 1.763 0 0
Glucose metabolism R-HSA-70326 1.740119e-02 1.759 0 0
PI3K/AKT activation R-HSA-198203 1.741149e-02 1.759 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.744307e-02 1.758 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.744307e-02 1.758 0 0
Vesicle-mediated transport R-HSA-5653656 1.760230e-02 1.754 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.792300e-02 1.747 0 0
Interleukin-12 signaling R-HSA-9020591 1.802335e-02 1.744 0 0
Regulation of KIT signaling R-HSA-1433559 1.811571e-02 1.742 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.896378e-02 1.722 0 0
HCMV Infection R-HSA-9609646 1.932549e-02 1.714 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.963138e-02 1.707 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.016812e-02 1.695 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.044867e-02 1.689 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.069591e-02 1.684 0 0
Cellular response to starvation R-HSA-9711097 2.095153e-02 1.679 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.116529e-02 1.674 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.153240e-02 1.667 0 0
Signaling by Hedgehog R-HSA-5358351 2.163554e-02 1.665 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.217647e-02 1.654 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.217647e-02 1.654 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.217647e-02 1.654 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.217647e-02 1.654 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.217647e-02 1.654 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.283759e-02 1.641 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.283759e-02 1.641 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.283759e-02 1.641 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.315133e-02 1.635 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.336224e-02 1.631 0 0
FLT3 Signaling R-HSA-9607240 2.363898e-02 1.626 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.391599e-02 1.621 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.391599e-02 1.621 0 0
Activation of the pre-replicative complex R-HSA-68962 2.391599e-02 1.621 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.837433e-02 1.547 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.837433e-02 1.547 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.837433e-02 1.547 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.837433e-02 1.547 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.588588e-02 1.587 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.144385e-02 1.502 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.144385e-02 1.502 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.687581e-02 1.571 0 0
Telomere Maintenance R-HSA-157579 2.538237e-02 1.595 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.621836e-02 1.581 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.754479e-02 1.560 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.778254e-02 1.556 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.735044e-02 1.563 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.634985e-02 1.579 0 0
NGF-stimulated transcription R-HSA-9031628 2.915799e-02 1.535 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.738811e-02 1.562 0 0
Reproduction R-HSA-1474165 3.117945e-02 1.506 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.776131e-02 1.557 0 0
Interleukin-12 family signaling R-HSA-447115 2.942491e-02 1.531 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.185553e-02 1.497 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 3.185553e-02 1.497 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.185553e-02 1.497 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.185553e-02 1.497 0 0
Interferon Signaling R-HSA-913531 3.312788e-02 1.480 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.565218e-02 1.448 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.571573e-02 1.447 0 0
rRNA processing R-HSA-72312 3.589838e-02 1.445 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.657077e-02 1.437 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.657077e-02 1.437 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.679227e-02 1.434 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.679227e-02 1.434 0 0
Repression of WNT target genes R-HSA-4641265 3.751745e-02 1.426 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.751745e-02 1.426 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.809328e-02 1.419 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.809328e-02 1.419 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.809328e-02 1.419 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.809328e-02 1.419 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.000804e-02 1.398 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.004687e-02 1.397 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.037484e-02 1.394 0 0
HIV Infection R-HSA-162906 4.075288e-02 1.390 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.173515e-02 1.379 0 0
Gene expression (Transcription) R-HSA-74160 4.174633e-02 1.379 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.197064e-02 1.377 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.318029e-02 1.365 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.375295e-02 1.359 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.375295e-02 1.359 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.394422e-02 1.357 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.394422e-02 1.357 0 0
DNA Repair R-HSA-73894 4.395224e-02 1.357 0 0
Sensory processing of sound R-HSA-9659379 4.412170e-02 1.355 0 0
Orc1 removal from chromatin R-HSA-68949 4.495855e-02 1.347 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.495855e-02 1.347 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.634791e-02 1.334 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.645207e-02 1.333 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.645207e-02 1.333 0 0
IRS activation R-HSA-74713 4.661685e-02 1.331 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.661685e-02 1.331 0 0
Reelin signalling pathway R-HSA-8866376 4.661685e-02 1.331 0 0
Dual Incision in GG-NER R-HSA-5696400 4.761825e-02 1.322 0 0
Gap junction assembly R-HSA-190861 4.761825e-02 1.322 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.793528e-02 1.319 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.793528e-02 1.319 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.793528e-02 1.319 0 0
Signaling by RAS mutants R-HSA-6802949 4.793528e-02 1.319 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.793528e-02 1.319 0 0
Rab regulation of trafficking R-HSA-9007101 4.864544e-02 1.313 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.949201e-02 1.305 1 1
GP1b-IX-V activation signalling R-HSA-430116 4.949201e-02 1.305 0 0
Unwinding of DNA R-HSA-176974 4.949201e-02 1.305 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.971908e-02 1.303 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.971908e-02 1.303 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.084828e-02 1.294 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.416109e-02 1.193 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.416109e-02 1.193 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.256042e-02 1.204 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.654559e-02 1.248 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.654559e-02 1.248 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.780025e-02 1.169 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.857866e-02 1.232 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.807946e-02 1.236 0 0
MAP2K and MAPK activation R-HSA-5674135 5.679823e-02 1.246 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.679823e-02 1.246 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.679823e-02 1.246 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.320331e-02 1.274 0 0
Neutrophil degranulation R-HSA-6798695 6.402063e-02 1.194 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.534569e-02 1.185 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.374762e-02 1.270 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.172393e-02 1.210 0 0
Co-stimulation by CD28 R-HSA-389356 5.884534e-02 1.230 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.749019e-02 1.171 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.036899e-02 1.219 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.586363e-02 1.181 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.416109e-02 1.193 0 0
Tight junction interactions R-HSA-420029 6.658360e-02 1.177 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.486829e-02 1.188 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.486829e-02 1.188 0 0
Degradation of CDH1 R-HSA-9766229 6.486829e-02 1.188 0 0
Rap1 signalling R-HSA-392517 5.857866e-02 1.232 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.090536e-02 1.293 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.090536e-02 1.293 0 0
Protein ubiquitination R-HSA-8852135 5.631332e-02 1.249 0 0
Selective autophagy R-HSA-9663891 5.578740e-02 1.253 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.256042e-02 1.204 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.231069e-02 1.281 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.105045e-02 1.292 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.586363e-02 1.181 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.090536e-02 1.293 0 0
Signaling by Interleukins R-HSA-449147 6.115289e-02 1.214 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.679823e-02 1.246 0 0
Formation of definitive endoderm R-HSA-9823730 6.832128e-02 1.165 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.926583e-02 1.159 0 0
Signaling by SCF-KIT R-HSA-1433557 6.988026e-02 1.156 0 0
TBC/RABGAPs R-HSA-8854214 6.988026e-02 1.156 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.127773e-02 1.147 0 0
DNA strand elongation R-HSA-69190 7.180659e-02 1.144 0 0
G0 and Early G1 R-HSA-1538133 7.180659e-02 1.144 0 0
Signaling by NOTCH R-HSA-157118 7.334424e-02 1.135 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.549230e-02 1.122 0 0
Myogenesis R-HSA-525793 7.579821e-02 1.120 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.579821e-02 1.120 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.599143e-02 1.119 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.599143e-02 1.119 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 7.659232e-02 1.116 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 7.659232e-02 1.116 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.659232e-02 1.116 0 0
Netrin-1 signaling R-HSA-373752 7.708050e-02 1.113 0 0
PECAM1 interactions R-HSA-210990 7.725764e-02 1.112 0 0
RNA Polymerase II Transcription R-HSA-73857 7.826357e-02 1.106 0 0
Prolonged ERK activation events R-HSA-169893 8.020368e-02 1.096 0 0
G-protein beta:gamma signalling R-HSA-397795 8.046927e-02 1.094 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.093427e-02 1.092 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.235307e-02 1.084 0 0
FOXO-mediated transcription R-HSA-9614085 8.284924e-02 1.082 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.325107e-02 1.080 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.325107e-02 1.080 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.357951e-02 1.078 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 8.427941e-02 1.074 0 0
Signaling by LTK in cancer R-HSA-9842640 8.427941e-02 1.074 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 8.427941e-02 1.074 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 8.427941e-02 1.074 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 8.427941e-02 1.074 0 0
Nef and signal transduction R-HSA-164944 8.427941e-02 1.074 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.472449e-02 1.072 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.527126e-02 1.069 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.572241e-02 1.067 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.572241e-02 1.067 0 0
Insulin processing R-HSA-264876 8.572241e-02 1.067 0 0
MAPK family signaling cascades R-HSA-5683057 8.607637e-02 1.065 0 0
Amyloid fiber formation R-HSA-977225 8.835899e-02 1.054 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.874142e-02 1.052 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.044382e-02 1.044 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.044382e-02 1.044 0 0
Synthesis of DNA R-HSA-69239 9.124657e-02 1.040 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.281309e-02 1.032 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.281309e-02 1.032 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.285930e-02 1.032 0 0
Signaling by GSK3beta mutants R-HSA-5339716 9.351634e-02 1.029 0 0
Integration of provirus R-HSA-162592 9.351634e-02 1.029 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 9.351634e-02 1.029 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.372997e-02 1.028 0 0
Disorders of Developmental Biology R-HSA-9675151 9.372997e-02 1.028 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.657180e-02 1.015 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.956906e-02 1.002 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.977547e-02 1.001 0 0
HIV Life Cycle R-HSA-162587 1.050959e-01 0.978 0 0
HCMV Late Events R-HSA-9610379 1.050959e-01 0.978 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.067159e-01 0.972 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.067159e-01 0.972 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.067159e-01 0.972 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.073161e-01 0.969 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.073161e-01 0.969 0 0
Heme signaling R-HSA-9707616 1.076191e-01 0.968 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.083409e-01 0.965 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.083409e-01 0.965 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.083409e-01 0.965 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.106936e-01 0.956 0 0
Integration of energy metabolism R-HSA-163685 1.110171e-01 0.955 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.112471e-01 0.954 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.112471e-01 0.954 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.112471e-01 0.954 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.112471e-01 0.954 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.112471e-01 0.954 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.112471e-01 0.954 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.112471e-01 0.954 0 0
Axonal growth stimulation R-HSA-209563 1.113293e-01 0.953 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.113293e-01 0.953 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.113293e-01 0.953 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.113293e-01 0.953 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.117774e-01 0.952 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.125714e-01 0.949 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.150934e-01 0.939 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.159853e-01 0.936 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.187675e-01 0.925 0 0
IRE1alpha activates chaperones R-HSA-381070 1.188444e-01 0.925 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.492473e-01 0.826 0 0
Regulation of gap junction activity R-HSA-191650 1.492473e-01 0.826 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.492473e-01 0.826 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.492473e-01 0.826 0 0
Type I hemidesmosome assembly R-HSA-446107 1.311866e-01 0.882 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.311866e-01 0.882 0 0
MET receptor recycling R-HSA-8875656 1.311866e-01 0.882 0 0
ARMS-mediated activation R-HSA-170984 1.573939e-01 0.803 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.573939e-01 0.803 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.303429e-01 0.885 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.506831e-01 0.822 0 0
GAB1 signalosome R-HSA-180292 1.239872e-01 0.907 0 0
PKA activation R-HSA-163615 1.239872e-01 0.907 0 0
PKA activation in glucagon signalling R-HSA-164378 1.239872e-01 0.907 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.721371e-01 0.764 0 0
Deadenylation of mRNA R-HSA-429947 1.299748e-01 0.886 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.581437e-01 0.801 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.765140e-01 0.753 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.765140e-01 0.753 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.323233e-01 0.878 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.456114e-01 0.837 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.763689e-01 0.754 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.763689e-01 0.754 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.703791e-01 0.769 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.541332e-01 0.812 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.541332e-01 0.812 0 0
Nucleotide Excision Repair R-HSA-5696398 1.248827e-01 0.903 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.765140e-01 0.753 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.581437e-01 0.801 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.703791e-01 0.769 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.765140e-01 0.753 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.299748e-01 0.886 0 0
Nuclear RNA decay R-HSA-9930044 1.595047e-01 0.797 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.311866e-01 0.882 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.573939e-01 0.803 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.406104e-01 0.852 0 0
Degradation of DVL R-HSA-4641258 1.325478e-01 0.878 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.303429e-01 0.885 0 0
Ca-dependent events R-HSA-111996 1.208385e-01 0.918 0 0
PLC beta mediated events R-HSA-112043 1.674317e-01 0.776 0 0
Calmodulin induced events R-HSA-111933 1.209927e-01 0.917 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.783858e-01 0.749 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.721371e-01 0.764 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.602105e-01 0.795 0 0
CaM pathway R-HSA-111997 1.209927e-01 0.917 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.506831e-01 0.822 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.383296e-01 0.859 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.595047e-01 0.797 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.492473e-01 0.826 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.492473e-01 0.826 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.492473e-01 0.826 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 1.573939e-01 0.803 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.329497e-01 0.876 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.376178e-01 0.861 0 0
Protein methylation R-HSA-8876725 1.721371e-01 0.764 0 0
FLT3 signaling in disease R-HSA-9682385 1.209927e-01 0.917 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.573939e-01 0.803 0 0
Somitogenesis R-HSA-9824272 1.541332e-01 0.812 0 0
Adrenoceptors R-HSA-390696 1.311866e-01 0.882 0 0
Protein hydroxylation R-HSA-9629569 1.581437e-01 0.801 0 0
Basigin interactions R-HSA-210991 1.765140e-01 0.753 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.299748e-01 0.886 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.541332e-01 0.812 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.581437e-01 0.801 0 0
Co-inhibition by PD-1 R-HSA-389948 1.288997e-01 0.890 0 0
Signaling by NOTCH4 R-HSA-9013694 1.472689e-01 0.832 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.763689e-01 0.754 0 0
tRNA processing in the nucleus R-HSA-6784531 1.783858e-01 0.749 0 0
Sodium/Proton exchangers R-HSA-425986 1.311866e-01 0.882 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.427475e-01 0.845 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.765140e-01 0.753 0 0
SARS-CoV Infections R-HSA-9679506 1.535093e-01 0.814 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.788617e-01 0.747 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.793962e-01 0.746 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.793962e-01 0.746 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.793962e-01 0.746 0 0
PTEN Regulation R-HSA-6807070 1.804208e-01 0.744 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.804208e-01 0.744 0 0
Death Receptor Signaling R-HSA-73887 1.807721e-01 0.743 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.839716e-01 0.735 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.839716e-01 0.735 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.850382e-01 0.733 0 0
2-LTR circle formation R-HSA-164843 1.850382e-01 0.733 0 0
Regulation of CDH11 function R-HSA-9762292 1.850382e-01 0.733 0 0
Signal attenuation R-HSA-74749 1.850382e-01 0.733 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.857953e-01 0.731 0 0
G alpha (12/13) signalling events R-HSA-416482 1.859577e-01 0.731 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.889795e-01 0.724 0 0
RAF activation R-HSA-5673000 1.889795e-01 0.724 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.889795e-01 0.724 0 0
Co-inhibition by BTLA R-HSA-9927353 1.892645e-01 0.723 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.892645e-01 0.723 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.892645e-01 0.723 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.892645e-01 0.723 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.892645e-01 0.723 0 0
Intraflagellar transport R-HSA-5620924 1.914046e-01 0.718 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.922318e-01 0.716 0 0
Hedgehog 'on' state R-HSA-5632684 1.934179e-01 0.714 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.945680e-01 0.711 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.945680e-01 0.711 0 0
Selenoamino acid metabolism R-HSA-2408522 1.947592e-01 0.711 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.956431e-01 0.709 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.956431e-01 0.709 0 0
Cellular response to chemical stress R-HSA-9711123 1.957899e-01 0.708 0 0
NRAGE signals death through JNK R-HSA-193648 1.970090e-01 0.706 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.980127e-01 0.703 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.031211e-01 0.692 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.031211e-01 0.692 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.031211e-01 0.692 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.031211e-01 0.692 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.031211e-01 0.692 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.031211e-01 0.692 0 0
Inhibition of PKR R-HSA-169131 2.031211e-01 0.692 0 0
Regulation of Apoptosis R-HSA-169911 2.044899e-01 0.689 0 0
Signaling by MET R-HSA-6806834 2.069457e-01 0.684 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.095224e-01 0.679 0 0
Late endosomal microautophagy R-HSA-9615710 2.105173e-01 0.677 0 0
DARPP-32 events R-HSA-180024 2.105173e-01 0.677 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.105173e-01 0.677 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.111841e-01 0.675 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.119020e-01 0.674 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.124742e-01 0.673 0 0
Signaling by APC mutants R-HSA-4839744 2.138260e-01 0.670 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.138260e-01 0.670 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.138260e-01 0.670 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.138260e-01 0.670 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.886491e-01 0.540 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.886491e-01 0.540 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.886491e-01 0.540 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.886491e-01 0.540 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.886491e-01 0.540 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.886491e-01 0.540 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.886491e-01 0.540 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.886491e-01 0.540 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.886491e-01 0.540 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.886491e-01 0.540 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.304942e-01 0.637 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.304942e-01 0.637 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.304942e-01 0.637 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.650019e-01 0.438 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.650019e-01 0.438 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 3.650019e-01 0.438 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.650019e-01 0.438 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.650019e-01 0.438 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.650019e-01 0.438 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.650019e-01 0.438 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.650019e-01 0.438 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.650019e-01 0.438 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.722158e-01 0.565 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.722158e-01 0.565 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.722158e-01 0.565 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.722158e-01 0.565 0 0
Activation of RAC1 R-HSA-428540 2.434764e-01 0.614 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.434764e-01 0.614 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.434764e-01 0.614 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 2.434764e-01 0.614 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 3.138492e-01 0.503 0 0
SOS-mediated signalling R-HSA-112412 3.138492e-01 0.503 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 3.138492e-01 0.503 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.331634e-01 0.363 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.331634e-01 0.363 0 0
MET activates PTPN11 R-HSA-8865999 4.331634e-01 0.363 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.331634e-01 0.363 0 0
Classical Kir channels R-HSA-1296053 4.331634e-01 0.363 0 0
Invadopodia formation R-HSA-8941237 4.331634e-01 0.363 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.178358e-01 0.662 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 2.178358e-01 0.662 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.737251e-01 0.563 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.737251e-01 0.563 0 0
Polymerase switching R-HSA-69091 2.737251e-01 0.563 0 0
Leading Strand Synthesis R-HSA-69109 2.737251e-01 0.563 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.549331e-01 0.450 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 3.549331e-01 0.450 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.043276e-01 0.517 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.043276e-01 0.517 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.043276e-01 0.517 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.043276e-01 0.517 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.663204e-01 0.575 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.567519e-01 0.590 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.350608e-01 0.475 0 0
Removal of the Flap Intermediate R-HSA-69166 3.350608e-01 0.475 0 0
Lipophagy R-HSA-9613354 3.951061e-01 0.403 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.657236e-01 0.437 0 0
Erythropoietin activates RAS R-HSA-9027284 3.657236e-01 0.437 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.997390e-01 0.523 0 0
Binding and entry of HIV virion R-HSA-173107 4.340905e-01 0.362 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.340905e-01 0.362 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.340905e-01 0.362 0 0
DNA replication initiation R-HSA-68952 4.340905e-01 0.362 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.340905e-01 0.362 0 0
Cristae formation R-HSA-8949613 3.216528e-01 0.493 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.463591e-01 0.608 0 0
Phosphorylation of the APC/C R-HSA-176412 3.961375e-01 0.402 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.961375e-01 0.402 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.961375e-01 0.402 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.739035e-01 0.562 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.608784e-01 0.584 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.608784e-01 0.584 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.899925e-01 0.538 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.899925e-01 0.538 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.906704e-01 0.537 0 0
Signaling by Erythropoietin R-HSA-9006335 3.659163e-01 0.437 0 0
FGFR2 alternative splicing R-HSA-6803529 3.927340e-01 0.406 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 4.261458e-01 0.370 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 4.261458e-01 0.370 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.058881e-01 0.514 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.881134e-01 0.411 0 0
Dual incision in TC-NER R-HSA-6782135 3.368279e-01 0.473 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.448868e-01 0.462 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.949283e-01 0.403 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.845769e-01 0.546 0 0
MET promotes cell motility R-HSA-8875878 2.536410e-01 0.596 0 0
Lagging Strand Synthesis R-HSA-69186 3.418946e-01 0.466 0 0
Protein folding R-HSA-391251 3.758493e-01 0.425 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.659163e-01 0.437 0 0
Developmental Cell Lineages R-HSA-9734767 3.930343e-01 0.406 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.657236e-01 0.437 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.425365e-01 0.615 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.580735e-01 0.588 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.895057e-01 0.409 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.998203e-01 0.523 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 2.536410e-01 0.596 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.358471e-01 0.627 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.283983e-01 0.641 0 0
Integrin signaling R-HSA-354192 2.845769e-01 0.546 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.340905e-01 0.362 0 0
Circadian clock R-HSA-9909396 3.265457e-01 0.486 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.927340e-01 0.406 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.961375e-01 0.402 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.203955e-01 0.657 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.083674e-01 0.389 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.083674e-01 0.389 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.235511e-01 0.490 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.963547e-01 0.402 0 0
DAP12 signaling R-HSA-2424491 2.283983e-01 0.641 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.309491e-01 0.480 0 0
GPVI-mediated activation cascade R-HSA-114604 2.204644e-01 0.657 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.204644e-01 0.657 0 0
Proteasome assembly R-HSA-9907900 2.425365e-01 0.615 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.631980e-01 0.440 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.322860e-01 0.364 0 0
PCP/CE pathway R-HSA-4086400 2.762068e-01 0.559 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.486898e-01 0.458 0 0
G-protein mediated events R-HSA-112040 2.377944e-01 0.624 0 0
Calcineurin activates NFAT R-HSA-2025928 3.951061e-01 0.403 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.559635e-01 0.592 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.951061e-01 0.403 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.657236e-01 0.437 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.905707e-01 0.537 0 0
Frs2-mediated activation R-HSA-170968 3.043276e-01 0.517 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.304942e-01 0.637 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.138492e-01 0.503 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.549331e-01 0.450 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.549331e-01 0.450 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.997390e-01 0.523 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.178358e-01 0.662 0 0
Platelet sensitization by LDL R-HSA-432142 2.663204e-01 0.575 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.951061e-01 0.403 0 0
Signaling by TGFB family members R-HSA-9006936 2.254506e-01 0.647 0 0
Platelet degranulation R-HSA-114608 2.669589e-01 0.574 0 0
UCH proteinases R-HSA-5689603 3.589233e-01 0.445 0 0
Stabilization of p53 R-HSA-69541 2.707578e-01 0.567 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.785839e-01 0.422 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.886491e-01 0.540 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.886491e-01 0.540 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.886491e-01 0.540 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.304942e-01 0.637 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.650019e-01 0.438 0 0
Signalling to ERK5 R-HSA-198765 3.650019e-01 0.438 0 0
Interleukin-33 signaling R-HSA-9014843 3.650019e-01 0.438 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.650019e-01 0.438 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.434764e-01 0.614 0 0
Signaling by AXIN mutants R-HSA-4839735 2.434764e-01 0.614 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.331634e-01 0.363 0 0
MET interacts with TNS proteins R-HSA-8875513 4.331634e-01 0.363 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.549331e-01 0.450 0 0
Co-stimulation by ICOS R-HSA-9927354 3.549331e-01 0.450 0 0
Negative regulation of MET activity R-HSA-6807004 3.164952e-01 0.500 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.368622e-01 0.626 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 4.340905e-01 0.362 0 0
DAG and IP3 signaling R-HSA-1489509 2.580735e-01 0.588 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.961375e-01 0.402 0 0
Signalling to ERKs R-HSA-187687 3.433189e-01 0.464 0 0
TCR signaling R-HSA-202403 2.304916e-01 0.637 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.562504e-01 0.448 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.102587e-01 0.387 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.069874e-01 0.390 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.999471e-01 0.398 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.051019e-01 0.516 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.462827e-01 0.461 0 0
Neurexins and neuroligins R-HSA-6794361 2.463591e-01 0.608 0 0
HDMs demethylate histones R-HSA-3214842 2.780776e-01 0.556 0 0
Syndecan interactions R-HSA-3000170 4.179647e-01 0.379 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.933820e-01 0.405 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.329912e-01 0.364 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.340905e-01 0.362 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.949283e-01 0.403 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.845769e-01 0.546 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.261458e-01 0.370 0 0
Adaptive Immune System R-HSA-1280218 2.417905e-01 0.617 0 0
Long-term potentiation R-HSA-9620244 2.780776e-01 0.556 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.261458e-01 0.370 0 0
DAP12 interactions R-HSA-2172127 3.780954e-01 0.422 0 0
Negative regulation of FLT3 R-HSA-9706369 3.961375e-01 0.402 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.840809e-01 0.416 0 0
MAP kinase activation R-HSA-450294 3.840809e-01 0.416 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.138492e-01 0.503 0 0
Signaling by LTK R-HSA-9842663 2.737251e-01 0.563 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.737251e-01 0.563 0 0
Disorders of Nervous System Development R-HSA-9697154 2.737251e-01 0.563 0 0
Pervasive developmental disorders R-HSA-9005895 2.737251e-01 0.563 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.951061e-01 0.403 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.731191e-01 0.428 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.609126e-01 0.584 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.138492e-01 0.503 0 0
Maturation of spike protein R-HSA-9683686 4.340905e-01 0.362 0 0
Interleukin-1 signaling R-HSA-9020702 2.955906e-01 0.529 0 0
Signaling by TGFBR3 R-HSA-9839373 4.146095e-01 0.382 0 0
Signaling by KIT in disease R-HSA-9669938 3.927340e-01 0.406 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.886491e-01 0.540 0 0
Inhibition of membrane repair R-HSA-9635644 2.886491e-01 0.540 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.886491e-01 0.540 0 0
TRAIL signaling R-HSA-75158 2.304942e-01 0.637 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.722158e-01 0.565 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.331634e-01 0.363 0 0
Physiological factors R-HSA-5578768 3.350608e-01 0.475 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.951061e-01 0.403 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.654871e-01 0.576 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.961375e-01 0.402 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.881686e-01 0.540 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.881686e-01 0.540 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.433189e-01 0.464 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.433189e-01 0.464 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.069874e-01 0.390 0 0
Hemostasis R-HSA-109582 2.528050e-01 0.597 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.816619e-01 0.550 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.927340e-01 0.406 0 0
Biotin transport and metabolism R-HSA-196780 3.657236e-01 0.437 0 0
Mitochondrial biogenesis R-HSA-1592230 4.186459e-01 0.378 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.463591e-01 0.608 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.179647e-01 0.379 0 0
Signaling by FGFR in disease R-HSA-1226099 3.309491e-01 0.480 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.707578e-01 0.567 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.707578e-01 0.567 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.039512e-01 0.517 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.588251e-01 0.587 0 0
Neurodegenerative Diseases R-HSA-8863678 2.567519e-01 0.590 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.567519e-01 0.590 0 0
Interleukin-1 family signaling R-HSA-446652 3.784998e-01 0.422 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.304942e-01 0.637 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.138492e-01 0.503 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.340905e-01 0.362 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.216528e-01 0.493 0 0
Degradation of AXIN R-HSA-4641257 3.831336e-01 0.417 0 0
Downstream signal transduction R-HSA-186763 4.102587e-01 0.387 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.299061e-01 0.367 0 0
Zinc transporters R-HSA-435354 3.350608e-01 0.475 0 0
RMTs methylate histone arginines R-HSA-3214858 3.780954e-01 0.422 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.178358e-01 0.662 0 0
Specification of primordial germ cells R-HSA-9827857 2.417996e-01 0.617 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.304942e-01 0.637 0 0
FasL/ CD95L signaling R-HSA-75157 4.331634e-01 0.363 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.417996e-01 0.617 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.951061e-01 0.403 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.039512e-01 0.517 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.235511e-01 0.490 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.067302e-01 0.391 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.731191e-01 0.428 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.900422e-01 0.409 0 0
Interleukin-7 signaling R-HSA-1266695 2.780776e-01 0.556 0 0
Signaling by Leptin R-HSA-2586552 4.340905e-01 0.362 0 0
Interleukin-37 signaling R-HSA-9008059 2.283983e-01 0.641 0 0
Generic Transcription Pathway R-HSA-212436 4.353821e-01 0.361 0 0
ER-Phagosome pathway R-HSA-1236974 4.356833e-01 0.361 0 0
Inositol phosphate metabolism R-HSA-1483249 4.376893e-01 0.359 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.408195e-01 0.356 0 0
Signaling by EGFR R-HSA-177929 4.408195e-01 0.356 0 0
Ion homeostasis R-HSA-5578775 4.408195e-01 0.356 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 4.408195e-01 0.356 0 0
Generation of second messenger molecules R-HSA-202433 4.427638e-01 0.354 0 0
Interleukin-2 family signaling R-HSA-451927 4.427638e-01 0.354 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.429443e-01 0.354 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.459162e-01 0.351 0 0
Signaling by ERBB4 R-HSA-1236394 4.532811e-01 0.344 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.541334e-01 0.343 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.541334e-01 0.343 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.556129e-01 0.341 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.624222e-01 0.335 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.624222e-01 0.335 0 0
TGFBR3 expression R-HSA-9839394 4.675899e-01 0.330 0 0
DNA Damage Bypass R-HSA-73893 4.689722e-01 0.329 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.716788e-01 0.326 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.716788e-01 0.326 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.716788e-01 0.326 0 0
Formation of the posterior neural plate R-HSA-9832991 4.716788e-01 0.326 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.716788e-01 0.326 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.716788e-01 0.326 0 0
Suppression of apoptosis R-HSA-9635465 4.716788e-01 0.326 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.716788e-01 0.326 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.757438e-01 0.323 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.757438e-01 0.323 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.818984e-01 0.317 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.818984e-01 0.317 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.844232e-01 0.315 0 0
Mismatch Repair R-HSA-5358508 4.844232e-01 0.315 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.844232e-01 0.315 0 0
Polo-like kinase mediated events R-HSA-156711 4.844232e-01 0.315 0 0
Tie2 Signaling R-HSA-210993 4.844232e-01 0.315 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.844232e-01 0.315 0 0
PI3K Cascade R-HSA-109704 4.868429e-01 0.313 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.918274e-01 0.308 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.940120e-01 0.306 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.940120e-01 0.306 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.940120e-01 0.306 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.940120e-01 0.306 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.940120e-01 0.306 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.940120e-01 0.306 0 0
Sensory perception of sour taste R-HSA-9729555 4.940120e-01 0.306 0 0
Dopamine receptors R-HSA-390651 4.940120e-01 0.306 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 4.940120e-01 0.306 0 0
eNOS activation R-HSA-203615 4.970649e-01 0.304 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.005202e-01 0.301 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.045350e-01 0.297 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.045350e-01 0.297 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.077215e-01 0.294 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.077215e-01 0.294 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.077215e-01 0.294 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.077215e-01 0.294 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.077215e-01 0.294 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.124800e-01 0.290 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.124800e-01 0.290 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.124800e-01 0.290 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.124800e-01 0.290 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.124800e-01 0.290 0 0
The NLRP3 inflammasome R-HSA-844456 5.124800e-01 0.290 0 0
Maturation of nucleoprotein R-HSA-9694631 5.124800e-01 0.290 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.155916e-01 0.288 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.155916e-01 0.288 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.155916e-01 0.288 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.155916e-01 0.288 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.155916e-01 0.288 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.163488e-01 0.287 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.180491e-01 0.286 0 0
PI Metabolism R-HSA-1483255 5.181546e-01 0.286 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.201497e-01 0.284 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.237252e-01 0.281 0 0
Interleukin-17 signaling R-HSA-448424 5.253054e-01 0.280 0 0
Gastrulation R-HSA-9758941 5.271141e-01 0.278 0 0
Potential therapeutics for SARS R-HSA-9679191 5.375043e-01 0.270 0 0
HIV elongation arrest and recovery R-HSA-167287 5.388253e-01 0.269 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.388253e-01 0.269 0 0
Pyroptosis R-HSA-5620971 5.388253e-01 0.269 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.397039e-01 0.268 0 0
Signal transduction by L1 R-HSA-445144 5.397039e-01 0.268 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.404410e-01 0.267 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.421175e-01 0.266 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.421175e-01 0.266 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.421175e-01 0.266 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.421175e-01 0.266 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.421175e-01 0.266 0 0
Opioid Signalling R-HSA-111885 5.433112e-01 0.265 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.483317e-01 0.261 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.483317e-01 0.261 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.483317e-01 0.261 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.483317e-01 0.261 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.483317e-01 0.261 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.483317e-01 0.261 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.483317e-01 0.261 0 0
Activation of AKT2 R-HSA-165158 5.483317e-01 0.261 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.483317e-01 0.261 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.483317e-01 0.261 0 0
Interleukin-36 pathway R-HSA-9014826 5.483317e-01 0.261 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.483317e-01 0.261 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.483317e-01 0.261 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.483317e-01 0.261 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 5.483317e-01 0.261 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.553924e-01 0.255 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.572384e-01 0.254 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.572384e-01 0.254 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.572384e-01 0.254 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.572384e-01 0.254 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.588409e-01 0.253 0 0
mRNA Capping R-HSA-72086 5.614795e-01 0.251 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.614795e-01 0.251 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.614795e-01 0.251 0 0
Platelet calcium homeostasis R-HSA-418360 5.614795e-01 0.251 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.614795e-01 0.251 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.660315e-01 0.247 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.660315e-01 0.247 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.660315e-01 0.247 0 0
Insulin receptor signalling cascade R-HSA-74751 5.713266e-01 0.243 0 0
Ion transport by P-type ATPases R-HSA-936837 5.713266e-01 0.243 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.748048e-01 0.240 0 0
Formation of axial mesoderm R-HSA-9796292 5.748048e-01 0.240 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.748048e-01 0.240 0 0
Maturation of nucleoprotein R-HSA-9683610 5.748048e-01 0.240 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.748048e-01 0.240 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.752728e-01 0.240 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.785769e-01 0.238 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.809135e-01 0.236 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.809135e-01 0.236 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.809135e-01 0.236 0 0
TNF signaling R-HSA-75893 5.893756e-01 0.230 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.914138e-01 0.228 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.914138e-01 0.228 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.914138e-01 0.228 0 0
Assembly Of The HIV Virion R-HSA-175474 5.914138e-01 0.228 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.929337e-01 0.227 0 0
Plus-strand DNA synthesis R-HSA-164525 5.968229e-01 0.224 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.968229e-01 0.224 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.968229e-01 0.224 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.968229e-01 0.224 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.968229e-01 0.224 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.968229e-01 0.224 0 0
Signaling by MST1 R-HSA-8852405 5.968229e-01 0.224 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.968229e-01 0.224 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.968229e-01 0.224 0 0
PDE3B signalling R-HSA-165160 5.968229e-01 0.224 0 0
Phosphorylation of Emi1 R-HSA-176417 5.968229e-01 0.224 0 0
PKB-mediated events R-HSA-109703 5.968229e-01 0.224 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.968229e-01 0.224 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.968229e-01 0.224 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.968229e-01 0.224 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.968229e-01 0.224 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.968229e-01 0.224 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.968229e-01 0.224 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.978329e-01 0.223 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.978329e-01 0.223 0 0
Signaling by ALK R-HSA-201556 5.978329e-01 0.223 0 0
EGFR downregulation R-HSA-182971 6.048913e-01 0.218 0 0
Budding and maturation of HIV virion R-HSA-162588 6.048913e-01 0.218 0 0
IRS-mediated signalling R-HSA-112399 6.054603e-01 0.218 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.057540e-01 0.218 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.057540e-01 0.218 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.057540e-01 0.218 0 0
Malate-aspartate shuttle R-HSA-9856872 6.057540e-01 0.218 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.057540e-01 0.218 0 0
Signal regulatory protein family interactions R-HSA-391160 6.057540e-01 0.218 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.057540e-01 0.218 0 0
HDL assembly R-HSA-8963896 6.057540e-01 0.218 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.066579e-01 0.217 0 0
Immune System R-HSA-168256 6.085015e-01 0.216 0 0
Gluconeogenesis R-HSA-70263 6.101997e-01 0.215 0 0
Metal ion SLC transporters R-HSA-425410 6.101997e-01 0.215 0 0
Signaling by NOTCH1 R-HSA-1980143 6.130424e-01 0.213 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.158149e-01 0.211 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.158149e-01 0.211 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.158149e-01 0.211 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.158149e-01 0.211 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.158149e-01 0.211 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.158149e-01 0.211 0 0
HIV Transcription Elongation R-HSA-167169 6.165840e-01 0.210 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.165840e-01 0.210 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.165840e-01 0.210 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.165840e-01 0.210 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.165840e-01 0.210 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.177573e-01 0.209 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.178391e-01 0.209 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.201261e-01 0.208 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.255875e-01 0.204 0 0
Signaling by WNT in cancer R-HSA-4791275 6.255875e-01 0.204 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.270520e-01 0.203 0 0
Regulated Necrosis R-HSA-5218859 6.311973e-01 0.200 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.348097e-01 0.197 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.348097e-01 0.197 0 0
Translesion synthesis by REV1 R-HSA-110312 6.349615e-01 0.197 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.349615e-01 0.197 0 0
p75NTR signals via NF-kB R-HSA-193639 6.349615e-01 0.197 0 0
DNA Damage Reversal R-HSA-73942 6.349615e-01 0.197 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.349615e-01 0.197 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.349615e-01 0.197 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.349615e-01 0.197 0 0
Formation of the anterior neural plate R-HSA-9823739 6.349615e-01 0.197 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.366016e-01 0.196 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.392105e-01 0.194 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.392105e-01 0.194 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.392105e-01 0.194 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.392105e-01 0.194 0 0
Growth hormone receptor signaling R-HSA-982772 6.392105e-01 0.194 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.401106e-01 0.194 0 0
STAT5 Activation R-HSA-9645135 6.401106e-01 0.194 0 0
Uncoating of the HIV Virion R-HSA-162585 6.401106e-01 0.194 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.401106e-01 0.194 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.401106e-01 0.194 0 0
Abacavir transmembrane transport R-HSA-2161517 6.401106e-01 0.194 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.401106e-01 0.194 0 0
CREB phosphorylation R-HSA-199920 6.401106e-01 0.194 0 0
HDL clearance R-HSA-8964011 6.401106e-01 0.194 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.401106e-01 0.194 0 0
VLDL assembly R-HSA-8866423 6.401106e-01 0.194 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.401106e-01 0.194 0 0
Neurofascin interactions R-HSA-447043 6.401106e-01 0.194 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.455804e-01 0.190 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.455804e-01 0.190 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.455804e-01 0.190 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.469166e-01 0.189 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.469166e-01 0.189 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.615868e-01 0.179 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.615868e-01 0.179 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.615868e-01 0.179 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.624444e-01 0.179 0 0
Translesion synthesis by POLI R-HSA-5656121 6.624444e-01 0.179 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.624444e-01 0.179 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.624444e-01 0.179 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.624444e-01 0.179 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.648545e-01 0.177 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.648545e-01 0.177 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.648545e-01 0.177 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.662846e-01 0.176 0 0
Signaling by FGFR2 R-HSA-5654738 6.666337e-01 0.176 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.719400e-01 0.173 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.756002e-01 0.170 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.783690e-01 0.169 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.783690e-01 0.169 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.787529e-01 0.168 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.787529e-01 0.168 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.787529e-01 0.168 0 0
Disinhibition of SNARE formation R-HSA-114516 6.787529e-01 0.168 0 0
Recycling of eIF2:GDP R-HSA-72731 6.787529e-01 0.168 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.787529e-01 0.168 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.787529e-01 0.168 0 0
PTK6 Expression R-HSA-8849473 6.787529e-01 0.168 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.787529e-01 0.168 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.787529e-01 0.168 0 0
Cysteine formation from homocysteine R-HSA-1614603 6.787529e-01 0.168 0 0
LDL remodeling R-HSA-8964041 6.787529e-01 0.168 0 0
VLDL clearance R-HSA-8964046 6.787529e-01 0.168 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.787529e-01 0.168 0 0
Regulation of PTEN localization R-HSA-8948747 6.787529e-01 0.168 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.787529e-01 0.168 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.787529e-01 0.168 0 0
CHL1 interactions R-HSA-447041 6.787529e-01 0.168 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.787529e-01 0.168 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.787529e-01 0.168 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.829388e-01 0.166 0 0
Formation of the nephric duct R-HSA-9830364 6.829388e-01 0.166 0 0
Signaling by NOTCH2 R-HSA-1980145 6.834000e-01 0.165 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.834000e-01 0.165 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.834000e-01 0.165 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.834000e-01 0.165 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.840778e-01 0.165 0 0
Downstream TCR signaling R-HSA-202424 6.855080e-01 0.164 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.861840e-01 0.164 0 0
Signaling by FGFR4 R-HSA-5654743 6.861840e-01 0.164 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.861840e-01 0.164 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.882364e-01 0.162 0 0
Translesion synthesis by POLK R-HSA-5655862 6.882364e-01 0.162 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.882364e-01 0.162 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.882364e-01 0.162 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.882364e-01 0.162 0 0
Translation R-HSA-72766 6.885820e-01 0.162 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.900443e-01 0.161 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.925950e-01 0.160 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.944302e-01 0.158 0 0
Infectious disease R-HSA-5663205 6.956995e-01 0.158 0 0
Ca2+ pathway R-HSA-4086398 6.990671e-01 0.155 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.012116e-01 0.154 0 0
PERK regulates gene expression R-HSA-381042 7.012116e-01 0.154 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.032694e-01 0.153 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.032694e-01 0.153 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.032694e-01 0.153 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.032694e-01 0.153 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.077130e-01 0.150 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.077130e-01 0.150 0 0
IGF1R signaling cascade R-HSA-2428924 7.079094e-01 0.150 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.123836e-01 0.147 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.123836e-01 0.147 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.123836e-01 0.147 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.123836e-01 0.147 0 0
Glycogen storage diseases R-HSA-3229121 7.123836e-01 0.147 0 0
Choline catabolism R-HSA-6798163 7.123836e-01 0.147 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.123836e-01 0.147 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.132482e-01 0.147 0 0
Minus-strand DNA synthesis R-HSA-164516 7.132482e-01 0.147 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.132482e-01 0.147 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.132482e-01 0.147 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.132482e-01 0.147 0 0
Regulation by c-FLIP R-HSA-3371378 7.132482e-01 0.147 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.132482e-01 0.147 0 0
Dimerization of procaspase-8 R-HSA-69416 7.132482e-01 0.147 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.132482e-01 0.147 0 0
phospho-PLA2 pathway R-HSA-111995 7.132482e-01 0.147 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.132482e-01 0.147 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.132482e-01 0.147 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.132482e-01 0.147 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.132482e-01 0.147 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.132482e-01 0.147 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.132482e-01 0.147 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.132482e-01 0.147 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.132482e-01 0.147 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.132482e-01 0.147 0 0
Interleukin-23 signaling R-HSA-9020933 7.132482e-01 0.147 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.175909e-01 0.144 0 0
Signaling by FGFR3 R-HSA-5654741 7.175909e-01 0.144 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.179667e-01 0.144 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.182885e-01 0.144 0 0
RNA Polymerase III Transcription R-HSA-74158 7.182885e-01 0.144 0 0
RUNX2 regulates bone development R-HSA-8941326 7.182885e-01 0.144 0 0
Triglyceride catabolism R-HSA-163560 7.182885e-01 0.144 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.209869e-01 0.142 0 0
Cellular response to hypoxia R-HSA-1234174 7.209869e-01 0.142 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.225884e-01 0.141 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.238367e-01 0.140 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.279901e-01 0.138 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.279901e-01 0.138 0 0
Signaling by FGFR1 R-HSA-5654736 7.324089e-01 0.135 0 0
Diseases of DNA repair R-HSA-9675135 7.324304e-01 0.135 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.349419e-01 0.134 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.349419e-01 0.134 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.349419e-01 0.134 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.349419e-01 0.134 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.349419e-01 0.134 0 0
Nephron development R-HSA-9831926 7.349419e-01 0.134 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.349419e-01 0.134 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.409112e-01 0.130 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.409112e-01 0.130 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.409112e-01 0.130 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.409112e-01 0.130 0 0
Inflammasomes R-HSA-622312 7.409112e-01 0.130 0 0
WNT mediated activation of DVL R-HSA-201688 7.440411e-01 0.128 0 0
CASP8 activity is inhibited R-HSA-5218900 7.440411e-01 0.128 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.440411e-01 0.128 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.440411e-01 0.128 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.440411e-01 0.128 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.440411e-01 0.128 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.440411e-01 0.128 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.440411e-01 0.128 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.440411e-01 0.128 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.440411e-01 0.128 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.440411e-01 0.128 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.440411e-01 0.128 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.502535e-01 0.125 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.502535e-01 0.125 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.502535e-01 0.125 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.559739e-01 0.121 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.559739e-01 0.121 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.559739e-01 0.121 0 0
Translesion Synthesis by POLH R-HSA-110320 7.559739e-01 0.121 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.559739e-01 0.121 0 0
Specification of the neural plate border R-HSA-9834899 7.559739e-01 0.121 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.566590e-01 0.121 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.582581e-01 0.120 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.582581e-01 0.120 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.583487e-01 0.120 0 0
Transmission across Chemical Synapses R-HSA-112315 7.600075e-01 0.119 0 0
GPER1 signaling R-HSA-9634597 7.603886e-01 0.119 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.651576e-01 0.116 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.666846e-01 0.115 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.710599e-01 0.113 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.715290e-01 0.113 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.715290e-01 0.113 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.715290e-01 0.113 0 0
Pexophagy R-HSA-9664873 7.715290e-01 0.113 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.715290e-01 0.113 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.715290e-01 0.113 0 0
Josephin domain DUBs R-HSA-5689877 7.715290e-01 0.113 0 0
Interleukin-27 signaling R-HSA-9020956 7.715290e-01 0.113 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.746534e-01 0.111 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.755473e-01 0.110 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.755473e-01 0.110 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.755473e-01 0.110 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.755473e-01 0.110 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.755473e-01 0.110 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.755473e-01 0.110 0 0
Signaling by NODAL R-HSA-1181150 7.755473e-01 0.110 0 0
Glycogen synthesis R-HSA-3322077 7.755473e-01 0.110 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.755473e-01 0.110 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.762434e-01 0.110 0 0
COPII-mediated vesicle transport R-HSA-204005 7.803044e-01 0.108 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.803044e-01 0.108 0 0
Leishmania phagocytosis R-HSA-9664417 7.813462e-01 0.107 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.813462e-01 0.107 0 0
Parasite infection R-HSA-9664407 7.813462e-01 0.107 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.822620e-01 0.107 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.822620e-01 0.107 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.822620e-01 0.107 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.822620e-01 0.107 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.822620e-01 0.107 0 0
Metabolism of polyamines R-HSA-351202 7.822620e-01 0.107 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.860870e-01 0.105 0 0
Signaling by FGFR R-HSA-190236 7.896329e-01 0.103 0 0
Regulation of insulin secretion R-HSA-422356 7.896329e-01 0.103 0 0
Trafficking of AMPA receptors R-HSA-399719 7.901245e-01 0.102 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.901245e-01 0.102 0 0
Cargo concentration in the ER R-HSA-5694530 7.901245e-01 0.102 0 0
Aquaporin-mediated transport R-HSA-445717 7.935583e-01 0.100 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.937328e-01 0.100 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.937328e-01 0.100 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.937328e-01 0.100 0 0
ERK/MAPK targets R-HSA-198753 7.937328e-01 0.100 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.960663e-01 0.099 0 0
LGI-ADAM interactions R-HSA-5682910 7.960663e-01 0.099 0 0
vRNA Synthesis R-HSA-192814 7.960663e-01 0.099 0 0
vRNP Assembly R-HSA-192905 7.960663e-01 0.099 0 0
Chylomicron assembly R-HSA-8963888 7.960663e-01 0.099 0 0
Synthesis of PI R-HSA-1483226 7.960663e-01 0.099 0 0
Bicarbonate transporters R-HSA-425381 7.960663e-01 0.099 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.960663e-01 0.099 0 0
Vitamin B1 (thiamin) metabolism R-HSA-196819 7.960663e-01 0.099 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.960663e-01 0.099 0 0
Interleukin-2 signaling R-HSA-9020558 7.960663e-01 0.099 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.960663e-01 0.099 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.057068e-01 0.094 0 0
Translation of Structural Proteins R-HSA-9683701 8.057068e-01 0.094 0 0
ABC-family proteins mediated transport R-HSA-382556 8.070863e-01 0.093 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.095913e-01 0.092 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.106025e-01 0.091 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.106025e-01 0.091 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.106025e-01 0.091 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 8.106025e-01 0.091 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.106025e-01 0.091 0 0
Signaling by Insulin receptor R-HSA-74752 8.162583e-01 0.088 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.178896e-01 0.087 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.179697e-01 0.087 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.179697e-01 0.087 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.179697e-01 0.087 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.179697e-01 0.087 0 0
NF-kB is activated and signals survival R-HSA-209560 8.179697e-01 0.087 0 0
ERKs are inactivated R-HSA-202670 8.179697e-01 0.087 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.179697e-01 0.087 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.179697e-01 0.087 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.179697e-01 0.087 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.179697e-01 0.087 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.184166e-01 0.087 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.184166e-01 0.087 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.246300e-01 0.084 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.247446e-01 0.084 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.262294e-01 0.083 0 0
Notch-HLH transcription pathway R-HSA-350054 8.262294e-01 0.083 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.262294e-01 0.083 0 0
LDL clearance R-HSA-8964038 8.262294e-01 0.083 0 0
Neuronal System R-HSA-112316 8.300360e-01 0.081 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.313031e-01 0.080 0 0
Heme degradation R-HSA-189483 8.313031e-01 0.080 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.375216e-01 0.077 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.375216e-01 0.077 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.375216e-01 0.077 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.375216e-01 0.077 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.375216e-01 0.077 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.375216e-01 0.077 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.375216e-01 0.077 0 0
Regulation of IFNG signaling R-HSA-877312 8.375216e-01 0.077 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.375216e-01 0.077 0 0
Interleukin-15 signaling R-HSA-8983432 8.375216e-01 0.077 0 0
Interleukin-35 Signalling R-HSA-8984722 8.375216e-01 0.077 0 0
OAS antiviral response R-HSA-8983711 8.375216e-01 0.077 0 0
Cyclin D associated events in G1 R-HSA-69231 8.403674e-01 0.076 0 0
G1 Phase R-HSA-69236 8.403674e-01 0.076 0 0
Amine ligand-binding receptors R-HSA-375280 8.403674e-01 0.076 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.406857e-01 0.075 0 0
Carnitine shuttle R-HSA-200425 8.406857e-01 0.075 0 0
G alpha (z) signalling events R-HSA-418597 8.409312e-01 0.075 0 0
Signaling by NOTCH3 R-HSA-9012852 8.409312e-01 0.075 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.433955e-01 0.074 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.433955e-01 0.074 0 0
RSV-host interactions R-HSA-9833110 8.459584e-01 0.073 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.468350e-01 0.072 0 0
Cardiac conduction R-HSA-5576891 8.496785e-01 0.071 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.540425e-01 0.069 0 0
Interleukin-6 family signaling R-HSA-6783589 8.540425e-01 0.069 0 0
Oncogene Induced Senescence R-HSA-2559585 8.547288e-01 0.068 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.549746e-01 0.068 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.549746e-01 0.068 0 0
Processing of SMDT1 R-HSA-8949664 8.549746e-01 0.068 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.549746e-01 0.068 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.549746e-01 0.068 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.549746e-01 0.068 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.549746e-01 0.068 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.549746e-01 0.068 0 0
Interleukin-6 signaling R-HSA-1059683 8.549746e-01 0.068 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.549746e-01 0.068 0 0
Transcription of the HIV genome R-HSA-167172 8.603546e-01 0.065 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.604672e-01 0.065 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.604672e-01 0.065 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.625498e-01 0.064 0 0
Glycosphingolipid transport R-HSA-9845576 8.653383e-01 0.063 0 0
G1/S-Specific Transcription R-HSA-69205 8.653383e-01 0.063 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.653383e-01 0.063 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.660874e-01 0.062 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.663692e-01 0.062 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.663692e-01 0.062 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.663692e-01 0.062 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.663692e-01 0.062 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.663692e-01 0.062 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.663692e-01 0.062 0 0
Hyaluronan degradation R-HSA-2160916 8.663692e-01 0.062 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.663692e-01 0.062 0 0
Laminin interactions R-HSA-3000157 8.663692e-01 0.062 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.678977e-01 0.062 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.678977e-01 0.062 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.705537e-01 0.060 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.705537e-01 0.060 0 0
Hydrolysis of LPC R-HSA-1483115 8.705537e-01 0.060 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.705537e-01 0.060 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.705537e-01 0.060 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.705537e-01 0.060 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.705537e-01 0.060 0 0
Extension of Telomeres R-HSA-180786 8.759845e-01 0.058 0 0
Peptide hormone metabolism R-HSA-2980736 8.761373e-01 0.057 0 0
MET activates PTK2 signaling R-HSA-8874081 8.777329e-01 0.057 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.777329e-01 0.057 0 0
Metalloprotease DUBs R-HSA-5689901 8.777329e-01 0.057 0 0
TRP channels R-HSA-3295583 8.777329e-01 0.057 0 0
RAB geranylgeranylation R-HSA-8873719 8.836464e-01 0.054 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.844600e-01 0.053 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.844600e-01 0.053 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.844600e-01 0.053 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.844600e-01 0.053 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.844600e-01 0.053 0 0
Signaling by Activin R-HSA-1502540 8.844600e-01 0.053 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 8.844600e-01 0.053 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.844600e-01 0.053 0 0
p38MAPK events R-HSA-171007 8.844600e-01 0.053 0 0
Chemokine receptors bind chemokines R-HSA-380108 8.865406e-01 0.052 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.881982e-01 0.051 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.881982e-01 0.051 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.881982e-01 0.051 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.900203e-01 0.051 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.931734e-01 0.049 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.968731e-01 0.047 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.968731e-01 0.047 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.968731e-01 0.047 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.968731e-01 0.047 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.968731e-01 0.047 0 0
Killing mechanisms R-HSA-9664420 8.968731e-01 0.047 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.968731e-01 0.047 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 8.968731e-01 0.047 0 0
Activation of SMO R-HSA-5635838 8.968731e-01 0.047 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.968731e-01 0.047 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.968731e-01 0.047 0 0
Atorvastatin ADME R-HSA-9754706 8.968731e-01 0.047 0 0
Differentiation of T cells R-HSA-9945266 8.968731e-01 0.047 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.968731e-01 0.047 0 0
Virus Assembly and Release R-HSA-168268 8.968731e-01 0.047 0 0
Mitochondrial protein import R-HSA-1268020 8.977591e-01 0.047 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.977591e-01 0.047 0 0
Signaling by PDGF R-HSA-186797 8.977591e-01 0.047 0 0
Insulin receptor recycling R-HSA-77387 8.978270e-01 0.047 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.978270e-01 0.047 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.978270e-01 0.047 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.012348e-01 0.045 0 0
Diseases of Immune System R-HSA-5260271 9.012348e-01 0.045 0 0
The phototransduction cascade R-HSA-2514856 9.014647e-01 0.045 0 0
Adipogenesis R-HSA-9843745 9.046185e-01 0.044 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.066781e-01 0.043 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.066781e-01 0.043 0 0
tRNA processing R-HSA-72306 9.070775e-01 0.042 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.076457e-01 0.042 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.079533e-01 0.042 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.079533e-01 0.042 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 9.079533e-01 0.042 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.079533e-01 0.042 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.079533e-01 0.042 0 0
Passive transport by Aquaporins R-HSA-432047 9.079533e-01 0.042 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.079533e-01 0.042 0 0
Coenzyme A biosynthesis R-HSA-196783 9.079533e-01 0.042 0 0
Maturation of spike protein R-HSA-9694548 9.087429e-01 0.042 0 0
Toll-like Receptor Cascades R-HSA-168898 9.092338e-01 0.041 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.143583e-01 0.039 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.146270e-01 0.039 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.148074e-01 0.039 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.148074e-01 0.039 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.148074e-01 0.039 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.148074e-01 0.039 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.148074e-01 0.039 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.157295e-01 0.038 0 0
Platelet homeostasis R-HSA-418346 9.177656e-01 0.037 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.178436e-01 0.037 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.178436e-01 0.037 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.178436e-01 0.037 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.178436e-01 0.037 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.178436e-01 0.037 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.178436e-01 0.037 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.178436e-01 0.037 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.178436e-01 0.037 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.178436e-01 0.037 0 0
Translation of Structural Proteins R-HSA-9694635 9.189717e-01 0.037 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.222251e-01 0.035 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.222679e-01 0.035 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.222679e-01 0.035 0 0
Integrin cell surface interactions R-HSA-216083 9.239259e-01 0.034 0 0
ABC transporter disorders R-HSA-5619084 9.239259e-01 0.034 0 0
Stimuli-sensing channels R-HSA-2672351 9.262276e-01 0.033 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.266717e-01 0.033 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.266717e-01 0.033 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.266717e-01 0.033 0 0
Kidney development R-HSA-9830369 9.267127e-01 0.033 0 0
Surfactant metabolism R-HSA-5683826 9.338606e-01 0.030 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.345516e-01 0.029 0 0
Methionine salvage pathway R-HSA-1237112 9.345516e-01 0.029 0 0
Other interleukin signaling R-HSA-449836 9.345516e-01 0.029 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.345516e-01 0.029 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.353785e-01 0.029 0 0
Ion channel transport R-HSA-983712 9.359109e-01 0.029 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.360841e-01 0.029 0 0
Extracellular matrix organization R-HSA-1474244 9.374562e-01 0.028 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.411195e-01 0.026 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.411195e-01 0.026 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.411195e-01 0.026 0 0
Creatine metabolism R-HSA-71288 9.415852e-01 0.026 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.415852e-01 0.026 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.415852e-01 0.026 0 0
Disease R-HSA-1643685 9.418849e-01 0.026 1 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.438711e-01 0.025 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.438711e-01 0.025 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.449033e-01 0.025 0 0
Triglyceride metabolism R-HSA-8979227 9.451898e-01 0.024 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.463734e-01 0.024 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.463734e-01 0.024 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.463734e-01 0.024 0 0
Mitophagy R-HSA-5205647 9.463734e-01 0.024 0 0
Hyaluronan metabolism R-HSA-2142845 9.463734e-01 0.024 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.478632e-01 0.023 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.478632e-01 0.023 0 0
Signalling to RAS R-HSA-167044 9.478632e-01 0.023 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.478632e-01 0.023 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.478632e-01 0.023 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.483310e-01 0.023 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.511785e-01 0.022 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.511785e-01 0.022 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.511785e-01 0.022 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.511785e-01 0.022 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.534669e-01 0.021 0 0
Attachment and Entry R-HSA-9694614 9.534669e-01 0.021 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.534669e-01 0.021 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.534669e-01 0.021 0 0
Glutathione synthesis and recycling R-HSA-174403 9.534669e-01 0.021 0 0
Ribavirin ADME R-HSA-9755088 9.534669e-01 0.021 0 0
HS-GAG biosynthesis R-HSA-2022928 9.555706e-01 0.020 0 0
SLC transporter disorders R-HSA-5619102 9.575245e-01 0.019 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.577812e-01 0.019 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.582612e-01 0.019 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.584686e-01 0.018 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.584686e-01 0.018 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.584686e-01 0.018 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.584686e-01 0.018 0 0
Voltage gated Potassium channels R-HSA-1296072 9.595829e-01 0.018 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.595829e-01 0.018 0 0
Azathioprine ADME R-HSA-9748787 9.598063e-01 0.018 0 0
Neddylation R-HSA-8951664 9.623570e-01 0.017 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.629329e-01 0.016 0 0
Formation of the ureteric bud R-HSA-9830674 9.629329e-01 0.016 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.629329e-01 0.016 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.633075e-01 0.016 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.669176e-01 0.015 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.669176e-01 0.015 0 0
Complex III assembly R-HSA-9865881 9.669176e-01 0.015 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.680243e-01 0.014 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.696388e-01 0.013 0 0
Glycogen metabolism R-HSA-8982491 9.696388e-01 0.013 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.700155e-01 0.013 0 0
G protein gated Potassium channels R-HSA-1296059 9.704741e-01 0.013 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.704741e-01 0.013 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.704741e-01 0.013 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.704741e-01 0.013 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.704741e-01 0.013 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.722788e-01 0.012 0 0
Parasitic Infection Pathways R-HSA-9824443 9.726933e-01 0.012 0 0
Leishmania infection R-HSA-9658195 9.726933e-01 0.012 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.736485e-01 0.012 0 0
Urea cycle R-HSA-70635 9.736485e-01 0.012 0 0
Abacavir ADME R-HSA-2161522 9.736485e-01 0.012 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.736485e-01 0.012 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.736485e-01 0.012 0 0
Paracetamol ADME R-HSA-9753281 9.737773e-01 0.012 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.739230e-01 0.011 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.739230e-01 0.011 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.749524e-01 0.011 0 0
HIV Transcription Initiation R-HSA-167161 9.749524e-01 0.011 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.749524e-01 0.011 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.749524e-01 0.011 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.764817e-01 0.010 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.764817e-01 0.010 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.764817e-01 0.010 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.767167e-01 0.010 0 0
Activation of GABAB receptors R-HSA-991365 9.772601e-01 0.010 0 0
GABA B receptor activation R-HSA-977444 9.772601e-01 0.010 0 0
Dectin-2 family R-HSA-5621480 9.779552e-01 0.010 0 0
Telomere Extension By Telomerase R-HSA-171319 9.790105e-01 0.009 0 0
Prednisone ADME R-HSA-9757110 9.790105e-01 0.009 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.790105e-01 0.009 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.793613e-01 0.009 0 0
Thyroxine biosynthesis R-HSA-209968 9.812675e-01 0.008 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.812675e-01 0.008 0 0
Glucagon-type ligand receptors R-HSA-420092 9.812675e-01 0.008 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.814859e-01 0.008 0 0
Peroxisomal protein import R-HSA-9033241 9.814941e-01 0.008 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.814941e-01 0.008 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.814941e-01 0.008 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.817253e-01 0.008 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.822356e-01 0.008 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.830137e-01 0.007 0 0
tRNA Aminoacylation R-HSA-379724 9.830532e-01 0.007 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.830532e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.832820e-01 0.007 0 0
Collagen degradation R-HSA-1442490 9.844861e-01 0.007 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.845961e-01 0.007 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.850799e-01 0.007 0 0
Protein localization R-HSA-9609507 9.856035e-01 0.006 0 0
Synthesis of PC R-HSA-1483191 9.860347e-01 0.006 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.866799e-01 0.006 0 0
DAG1 glycosylations R-HSA-8931838 9.866845e-01 0.006 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.866845e-01 0.006 0 0
HS-GAG degradation R-HSA-2024096 9.866845e-01 0.006 0 0
Interleukin-10 signaling R-HSA-6783783 9.878716e-01 0.005 0 0
Formation of the cornified envelope R-HSA-6809371 9.880636e-01 0.005 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.885301e-01 0.005 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.892214e-01 0.005 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.893949e-01 0.005 0 0
Innate Immune System R-HSA-168249 9.895581e-01 0.005 0 0
Interferon gamma signaling R-HSA-877300 9.900223e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.902717e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.905357e-01 0.004 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.905357e-01 0.004 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.905357e-01 0.004 0 0
RA biosynthesis pathway R-HSA-5365859 9.905357e-01 0.004 0 0
Signal amplification R-HSA-392518 9.905357e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.909287e-01 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 9.914520e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.914520e-01 0.004 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.915538e-01 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.924624e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.932734e-01 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.932734e-01 0.003 0 0
Lysine catabolism R-HSA-71064 9.932734e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.932734e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.936932e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.936932e-01 0.003 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.939971e-01 0.003 0 0
Elastic fibre formation R-HSA-1566948 9.939971e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.939971e-01 0.003 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.942449e-01 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.942821e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.945766e-01 0.002 0 0
Pentose phosphate pathway R-HSA-71336 9.946430e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.946430e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.948276e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.952195e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.957339e-01 0.002 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.957699e-01 0.002 0 0
Regulation of beta-cell development R-HSA-186712 9.957699e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.959733e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.961756e-01 0.002 0 0
Glutathione conjugation R-HSA-156590 9.961756e-01 0.002 0 0
Intra-Golgi traffic R-HSA-6811438 9.961930e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.961930e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.966028e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.968901e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.972947e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.972947e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.975859e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.975859e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.980777e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.982847e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.983032e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.984694e-01 0.001 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.985818e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.987104e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.987521e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.987813e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.989163e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.989839e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.991341e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.991731e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.992509e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.992611e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.992740e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.992946e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.993403e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.993538e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.993752e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.993752e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.993935e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.994305e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.994532e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.995518e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.995630e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.996866e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.996896e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997231e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.997340e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997677e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.997688e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.997767e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998033e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998033e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998245e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998754e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.998754e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999115e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999115e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999210e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999439e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999487e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999487e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999509e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999557e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999602e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999712e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999717e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999799e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999863e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999871e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999872e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999873e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999877e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999936e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999956e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999981e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999982e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999983e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999989e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999990e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999991e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999992e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999996e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999996e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999996e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999998e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999998e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways