ERK7

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	T949	Sugiyama	POTEF A26C1B	TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
O14545	T323	Sugiyama	TRAFD1 FLN29	ELLIDHQTSCNPSRALPsLNtGsssPRGVEEPDVIFQNFLQ
O14745	S280	Sugiyama	NHERF1 NHERF SLC9A3R1	tNGEIQKENsREALAEAALEsPRPALVRsAssDtsEELNsQ
O15085	S251	Sugiyama	ARHGEF11 KIAA0380	PsLsEsLMNRNsVLsDPGLDsPRtsPVIMARVAQHHRRQGs
O43707	T249	Sugiyama	ACTN4	EVAEKyLDIPKMLDAEDIVNtARPDEKAIMTyVssFyHAFs
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75533	T313	Sugiyama	SF3B1 SAP155	WDEtPKtERDtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsK
O75828	S56	Sugiyama	CBR3 SDR21C2	TARDVARGQAAVQQLQAEGLsPRFHQLDIDDLQsIRALRDF
P00338	S167	Sugiyama	LDHA PIG19	AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05412	S63	SIGNOR\|EPSD\|PSP	JUN	ADPVGSLKPHLRAKNsDLLtsPDVGLLKLAsPELERLIIQS
P05412	S73	SIGNOR\|EPSD\|PSP	JUN	LRAKNsDLLtsPDVGLLKLAsPELERLIIQSSNGHItttPt
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P07195	S168	Sugiyama	LDHB	TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07437	S75	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P08195	S296	Sugiyama	SLC3A2 MDU1	DLLQIDPNFGsKEDFDsLLQsAKKKSIRVILDLTPNYRGEN
P08651	S343	Sugiyama	NFIC NFI	sPVKKtEMDKsPFNsPsPQDsPRLSsFTQHHRPVIAVHSGI
P10809	S70	Sugiyama	HSPD1 HSP60	AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P10809	T231	Sugiyama	HSPD1 HSP60	LEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLsEKKI
P11142	T47	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13798	S304	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	YVDLIGGKCELLSDDsLAVssPRLSPDQCRIVYLQYPSLIP
P13929	T26	Sugiyama	ENO3	IFAREILDsRGNPtVEVDLHtAKGRFRAAVPsGAstGIyEA
P14618	S55	Sugiyama	PKM OIP3 PK2 PK3 PKM2	IDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMNVARLN
P14618	T121	Sugiyama	PKM OIP3 PK2 PK3 PKM2	DPILyRPVAVALDTKGPEIRtGLIKGsGtAEVELKKGATLK
P14618	T41	Sugiyama	PKM OIP3 PK2 PK3 PKM2	AMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtL
P16070	T76	Sugiyama	CD44 LHR MDU2 MDU3 MIC4	FNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRIHPNSI
P16152	S56	Sugiyama	CBR1 CBR CRN SDR21C1	TARDVTRGQAAVQQLQAEGLsPRFHQLDIDDLQsIRALRDF
P16949	S25	Sugiyama	STMN1 C1orf215 LAP18 OP18	DIQVKELEKRAsGQAFELILsPRsKEsVPEFPLsPPKKKDL
P17066	T49	Sugiyama	HSPA6 HSP70B'	EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P22234	S27	Sugiyama	PAICS ADE2 AIRC PAIS	LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P25786	S14	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	_______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P25963	S32	EPSD\|PSP	NFKBIA IKBA MAD3 NFKBI	AMEGPRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEI
P25963	S36	EPSD\|PSP	NFKBIA IKBA MAD3 NFKBI	PRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEIRLEP
P26232	S667	Sugiyama	CTNNA2 CAPR	YDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEEKAKIAEQV
P26640	S301	Sugiyama	VARS1 G7A VARS VARS2	DLPtPPGEKKDVSGPMPDsysPRYVEAAWYPWWEQQGFFKP
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797	S53	Sugiyama	CALR CRTC	WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27824	S583	Sugiyama	CANX	VsQEEEDRKPKAEEDEILNRsPRNRKPRRE___________
P28715	S384	Sugiyama	ERCC5 ERCM2 XPG XPGC	ENRRQARGRNAPAAVDEGsIsPRtLSAIKRALDDDEDVKVC
P29144	S93	Sugiyama	TPP2	SGDVNTATEVEPKDGEIVGLsGRVLKIPASWTNPSGKYHIG
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30086	S139	Sugiyama	PEBP1 PBP PEBP	RyVWLVyEQDRPLKCDEPILsNRsGDHRGKFKVAsFRKKyE
P31948	Y41	Sugiyama	STIP1	DDALQCysEAIKLDPHNHVLysNRsAAyAKKGDYQKAyEDG
P34931	T49	Sugiyama	HSPA1L	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P35221	S668	Sugiyama	CTNNA1	FDVRsRtsVQtEDDQLIAGQsARAIMAQLPQEQKAKIAEQV
P35658	S661	Sugiyama	NUP214 CAIN CAN KIAA0023	SSVLPSPSGRSAQGSSSPVPsMVQKSPRItPPAAKPGsPQA
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P47756	S90	Sugiyama	CAPZB	SyRsPWSNKyDPPLEDGAMPsARLRKLEVEANNAFDQYRDL
P48741	T49	Sugiyama	HSPA7 HSP70B	EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P53396	S481	Sugiyama	ACLY	ADEVAPAKKAKPAMPQDsVPsPRSLQGKSTTLFSRHTKAIV
P54652	T48	Sugiyama	HSPA2	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P60709	T249	Sugiyama	ACTB	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P61978	S284	Sugiyama	HNRNPK HNRPK	MPPGRGGRPMPPSRRDyDDMsPRRGPPPPPPGRGGRGGsRA
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263	T140	Sugiyama	RPS14 PRO2640	ARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL_________
P62736	T251	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62826	T21	Sugiyama	RAN ARA24 OK/SW-cl.81	MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62851	S74	Sugiyama	RPS25	tyDKLCKEVPNYKLItPAVVsERLKIRGSLARAALQELLsK
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261	T249	Sugiyama	ACTG1 ACTG	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63267	T250	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032	T251	Sugiyama	ACTC1 ACTC	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133	T251	Sugiyama	ACTA1 ACTA	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	Y83	Sugiyama	TUBA1B	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P85037	S428	Sugiyama	FOXK1 MNF	PFGPLssRsAPAsPtHPGLMsPRsGGLQtPECLsREGsPIP
Q01082	S2138	Sugiyama	SPTBN1 SPTB2	QWDtsKGEQVsQNGLPAEQGsPRMAETVDTsEMVNGAtEQR
Q01105	S166	Sugiyama	SET	yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q04726	T259	Sugiyama	TLE3 KIAA1547	DsDGDKsDDLVVDVsNEDPAtPRVsPAHsPPENGLDKARSL
Q04727	S265	Sugiyama	TLE4 GRG4 KIAA1261	sDGEKsDDNLVVDVSNEDPssPRGsPAHSPRENGLDKTRLL
Q08J23	S383	Sugiyama	NSUN2 SAKI TRM4	QWKVMTKDGQWFTDWDAVPHsRHTQIRPTMFPPKDPEKLQA
Q13509	S75	Sugiyama	TUBB3 TUBB4	SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13610	S65	Sugiyama	PWP1	EEGGGsDEEEtGsPsEDGMQsARTQARPREPLEDGDPEDDR
Q13643	T175	Sugiyama	FHL3 SLIM2	ENKFAPRCARCSKTLTQGGVtYRDQPWHRECLVCtGCQtPL
Q13885	S75	Sugiyama	TUBB2A TUBB2	AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14152	T1378	Sugiyama	EIF3A EIF3S10 KIAA0139	AEKDREsLRRTKNEtDEDGWttVRR________________
Q14152	T1379	Sugiyama	EIF3A EIF3S10 KIAA0139	EKDREsLRRTKNEtDEDGWttVRR_________________
Q14247	S432	Sugiyama	CTTN EMS1	EERLPssPVyEDAAsFKAELsyRGPVsGtEPEPVysMEAAD
Q14C86	S1019	Sugiyama	GAPVD1 GAPEX5 KIAA1521 RAP6	QEKDKDDLGPDRFstLTDDPsPRLSAQAQVAEDILDKYRNA
Q16204	S244	Sugiyama	CCDC6 D10S170 TST1	LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q2NL82	T490	Sugiyama	TSR1 KIAA1401	KMLEKYKQERLEEMFPDEVDtPRDVAARIRFQKYRGLKSFR
Q3ZCM7	S75	Sugiyama	TUBB8	SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q562R1	T107	Sugiyama	ACTBL2	WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q562R1	T250	Sugiyama	ACTBL2	RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q69YN4	S1578	Sugiyama	VIRMA KIAA1429 MSTP054	KCCSDFDLHSELERsFLsEPssPGRtKTTKGFKLGKHKHET
Q69YN4	S1579	Sugiyama	VIRMA KIAA1429 MSTP054	CCSDFDLHSELERsFLsEPssPGRtKTTKGFKLGKHKHETF
Q6PKG0	S627	Sugiyama	LARP1 KIAA0731 LARP	FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6S8J3	T949	Sugiyama	POTEE A26C1A POTE2	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6ZMR3	S167	Sugiyama	LDHAL6A LDHL2	AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	Y83	Sugiyama	TUBA1A TUBA3	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7KZF4	S126	Sugiyama	SND1 TDRD11	GREyGMIyLGKDTNGENIAEsLVAEGLAtRREGMRANNPEQ
Q7Z6M1	S137	Sugiyama	RABEPK RAB9P40	QVLNPETRTWTTPEVtsPPPsPRTFHTSSAAIGNQLYVFGG
Q86VV8	S310	Sugiyama	RTTN	SYCHEARGTHHSQNPsPGsssPRPSVVGRTGQRPRGDGQDW
Q86YP4	S114	Sugiyama	GATAD2A	SERRPPsPDVIVLsDNEQPssPRVNGLttVALKETSTEALM
Q8IZ83	T422	Sugiyama	ALDH16A1	PVVVASPFRTAKEALLVANGtPRGGsASVWSERLGQALELG
Q8NFD5	S1744	Sugiyama	ARID1B BAF250B DAN15 KIAA1235 OSA2	ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TB72	S82	Sugiyama	PUM2 KIAA0235 PUMH2	MVQRRsGQGFHGNsEVNAILsPRsEsGGLGVsMVEYVLsss
Q8TD08	S191	Sugiyama	MAPK15 ERK7 ERK8	DQAVtEyVAtRWyRAPEVLLssHRYTLGVDMWSLGCILGEM
Q8TD08	S192	EPSD\|PSP	MAPK15 ERK7 ERK8	QAVtEyVAtRWyRAPEVLLssHRYTLGVDMWSLGCILGEML
Q8TD08	S259	Sugiyama	MAPK15 ERK7 ERK8	EEDLLALGSGCRASVLHQLGsRPRQTLDALLPPDTSPEALD
Q8TD08	S311	Sugiyama	MAPK15 ERK7 ERK8	KRLSATQALQHPYVQRFHCPsDEWAREADVRPRAHEGVQLs
Q8TD08	S331	EPSD\|PSP\|Sugiyama	MAPK15 ERK7 ERK8	sDEWAREADVRPRAHEGVQLsVPEyRSRVYQMILECGGssG
Q8TD08	S349	Sugiyama	MAPK15 ERK7 ERK8	QLsVPEyRSRVYQMILECGGssGtsREKGPEGVsPsQAHLH
Q8TD08	S350	Sugiyama	MAPK15 ERK7 ERK8	LsVPEyRSRVYQMILECGGssGtsREKGPEGVsPsQAHLHK
Q8TD08	S353	Sugiyama	MAPK15 ERK7 ERK8	PEyRSRVYQMILECGGssGtsREKGPEGVsPsQAHLHKPRA
Q8TD08	S362	EPSD\|PSP\|Sugiyama	MAPK15 ERK7 ERK8	MILECGGssGtsREKGPEGVsPsQAHLHKPRADPQLPsRtP
Q8TD08	S364	Sugiyama	MAPK15 ERK7 ERK8	LECGGssGtsREKGPEGVsPsQAHLHKPRADPQLPsRtPVQ
Q8TD08	S379	EPSD\|PSP	MAPK15 ERK7 ERK8	EGVsPsQAHLHKPRADPQLPsRtPVQGPRPRPQSSPGHDPA
Q8TD08	S415	Sugiyama	MAPK15 ERK7 ERK8	GHDPAEHESPRAAKNVPRQNsAPLLQtALLGNGERPPGAKE
Q8TD08	S442	Sugiyama	MAPK15 ERK7 ERK8	ALLGNGERPPGAKEAPPLtLsLVKPsGRGAAPSLTSQAAAQ
Q8TD08	S447	Sugiyama	MAPK15 ERK7 ERK8	GERPPGAKEAPPLtLsLVKPsGRGAAPSLTSQAAAQVANQA
Q8TD08	S503	Sugiyama	MAPK15 ERK7 ERK8	SVQQVPPRLPPEARPGRRMFstsALQGAQGGARALLGGYSQ
Q8TD08	S505	Sugiyama	MAPK15 ERK7 ERK8	QQVPPRLPPEARPGRRMFstsALQGAQGGARALLGGYSQAY
Q8TD08	T150	Sugiyama	MAPK15 ERK7 ERK8	SGHVVHRDQKPSNVLLDANCtVKLCDFGLARSLGDLPEGPE
Q8TD08	T175	SIGNOR\|EPSD\|PSP\|Sugiyama	MAPK15 ERK7 ERK8	DFGLARSLGDLPEGPEDQAVtEyVAtRWyRAPEVLLssHRY
Q8TD08	T180	Sugiyama	MAPK15 ERK7 ERK8	RSLGDLPEGPEDQAVtEyVAtRWyRAPEVLLssHRYTLGVD
Q8TD08	T352	EPSD\|PSP\|Sugiyama	MAPK15 ERK7 ERK8	VPEyRSRVYQMILECGGssGtsREKGPEGVsPsQAHLHKPR
Q8TD08	T381	EPSD\|PSP	MAPK15 ERK7 ERK8	VsPsQAHLHKPRADPQLPsRtPVQGPRPRPQSSPGHDPAEH
Q8TD08	T421	Sugiyama	MAPK15 ERK7 ERK8	HESPRAAKNVPRQNsAPLLQtALLGNGERPPGAKEAPPLtL
Q8TD08	T440	Sugiyama	MAPK15 ERK7 ERK8	QtALLGNGERPPGAKEAPPLtLsLVKPsGRGAAPSLTSQAA
Q8TD08	T504	Sugiyama	MAPK15 ERK7 ERK8	VQQVPPRLPPEARPGRRMFstsALQGAQGGARALLGGYSQA
Q8TD08	Y177	SIGNOR\|EPSD\|PSP\|Sugiyama	MAPK15 ERK7 ERK8	GLARSLGDLPEGPEDQAVtEyVAtRWyRAPEVLLssHRYTL
Q8TD08	Y183	Sugiyama	MAPK15 ERK7 ERK8	GDLPEGPEDQAVtEyVAtRWyRAPEVLLssHRYTLGVDMWS
Q8TD08	Y335	Sugiyama	MAPK15 ERK7 ERK8	AREADVRPRAHEGVQLsVPEyRSRVYQMILECGGssGtsRE
Q8WWI1	S1516	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	KEPVSLPGIMRRGEsLDNLDsPRSNSWRQPPWLNQPTGFYA
Q92974	T914	Sugiyama	ARHGEF2 KIAA0651 LFP40	yLsFNPPQPSRGTDRLDLPVtTRSVHRNFEDRERQELGsPE
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q99497	T154	Sugiyama	PARK7	MNGGHytysENRVEKDGLILtSRGPGTSFEFALAIVEALNG
Q99798	T646	Sugiyama	ACO2	NGKANSVRNAVTQEFGPVPDtARYYKKHGIRWVVIGDENyG
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	Y83	Sugiyama	TUBA1C TUBA6	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BVA1	S75	Sugiyama	TUBB2B	tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BX95	T114	Sugiyama	SGPP1 SPP1	AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9BYX7	T249	Sugiyama	POTEKP ACTBL3 FKSG30	MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9GZT8	T149	Sugiyama	NIF3L1 ALS2CR1 MDS015 My018	AYDAAPQGVNNWLAKGLGACtSRPIHPSKAPNyPTEGNHRV
Q9H6F5	S110	Sugiyama	CCDC86 CYCLON	AsPQRQQDLHLEsPQRQPEysPEsPRCQPKPSEEAPKCsQD
Q9H6F5	S113	Sugiyama	CCDC86 CYCLON	QRQQDLHLEsPQRQPEysPEsPRCQPKPSEEAPKCsQDQGV
Q9H6T3	T491	Sugiyama	RPAP3	ATGTTSKKNssQDDLFPTsDtPRAKVLKIEEVsDTssLQPQ
Q9H773	S85	Sugiyama	DCTPP1 XTP3TPA CDA03	GELAELFQWKTDGEPGPQGWsPRERAALQEELSDVLIYLVA
Q9NY27	T173	Sugiyama	PPP4R2 SBBI57	VMFPGNsPsytERSNINGPGtPRPLNRPKVsLSAPMTTNGL
Q9NZT2	S378	Sugiyama	OGFR	LERsQGDEAGGHGEDRPEPLsPKEsKKRKLELSRREQPPTE
Q9UI10	T86	Sugiyama	EIF2B4 EIF2BD	AAQCQVGPTRELPESGIQLGtPREKVPAGRSKAELRAERRA
Q9ULD2	S1255	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	HNGDLCsPKRsPtssAIPLQsPRNsGsFPsPsIsPR_____
Q9ULD2	S1268	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	ssAIPLQsPRNsGsFPsPsIsPR__________________
Q9UPW0	S223	Sugiyama	FOXJ3 KIAA1041	AINTVTNKVTLYNTDQDGsDsPRSSLNNSLSDQSLASVNLN
Q9Y3F4	S228	Sugiyama	STRAP MAWD UNRIP	FHSAVSLDPIKsFEAPAtINsAsLHPEKEFLVAGGEDFKLy
Q9Y5U2	S146	Sugiyama	TSSC4	LAPsGRsPVEGLGRAHRsPAsPRVPPVPDYVAHPERWTKYS

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle, Mitotic	R-HSA-69278	1.515377e-08	7.819
Cell Cycle	R-HSA-1640170	2.254729e-08	7.647
Nuclear import of Rev protein	R-HSA-180746	1.183884e-06	5.927
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.823382e-06	5.739
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.405385e-06	5.619
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.405385e-06	5.619
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.536421e-06	5.596
IPs transport between nucleus and cytosol	R-HSA-1855170	4.079392e-06	5.389
Transport of the SLBP independent Mature mRNA	R-HSA-159227	4.079392e-06	5.389
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.249042e-06	5.280
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.074126e-06	5.390
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	5.115503e-06	5.291
Interactions of Vpr with host cellular proteins	R-HSA-176033	5.115503e-06	5.291
Interactions of Rev with host cellular proteins	R-HSA-177243	5.115503e-06	5.291
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	5.249042e-06	5.280
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	8.500721e-06	5.071
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	8.452447e-06	5.073
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.008024e-05	4.997
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.666219e-05	4.778
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.059989e-05	4.686
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.813531e-05	4.551
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.786885e-05	4.555
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.096488e-05	4.509
Nuclear Envelope Breakdown	R-HSA-2980766	3.519615e-05	4.454
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.691397e-05	4.433
M Phase	R-HSA-68886	5.766153e-05	4.239
Chromatin organization	R-HSA-4839726	5.887043e-05	4.230
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.347665e-05	4.134
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.860409e-05	4.105
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	8.825603e-05	4.054
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	9.051423e-05	4.043
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.343689e-05	4.029
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.000441e-04	4.000
NRAGE signals death through JNK	R-HSA-193648	1.173429e-04	3.931
Apoptosis induced DNA fragmentation	R-HSA-140342	1.259826e-04	3.900
Mitotic Prometaphase	R-HSA-68877	1.490872e-04	3.827
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.575349e-04	3.803
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.951270e-04	3.710
Host Interactions of HIV factors	R-HSA-162909	2.087621e-04	3.680
tRNA processing in the nucleus	R-HSA-6784531	2.760174e-04	3.559
p75 NTR receptor-mediated signalling	R-HSA-193704	2.962290e-04	3.528
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.363863e-04	3.473
Transport of connexons to the plasma membrane	R-HSA-190872	4.372311e-04	3.359
ATP-dependent chromatin remodelers	R-HSA-9932444	5.143980e-04	3.289
SWI/SNF chromatin remodelers	R-HSA-9932451	5.143980e-04	3.289
Chromatin modifying enzymes	R-HSA-3247509	5.063346e-04	3.296
Death Receptor Signaling	R-HSA-73887	5.548419e-04	3.256
snRNP Assembly	R-HSA-191859	6.384082e-04	3.195
Metabolism of non-coding RNA	R-HSA-194441	6.384082e-04	3.195
Selective autophagy	R-HSA-9663891	6.508474e-04	3.187
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	7.107706e-04	3.148
Mitotic Anaphase	R-HSA-68882	7.537388e-04	3.123
Mitotic Metaphase and Anaphase	R-HSA-2555396	8.012442e-04	3.096
Viral Messenger RNA Synthesis	R-HSA-168325	8.203195e-04	3.086
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.201059e-04	3.036
Transcriptional regulation by small RNAs	R-HSA-5578749	9.363298e-04	3.029
Mitotic Prophase	R-HSA-68875	9.946825e-04	3.002
Macroautophagy	R-HSA-1632852	1.093288e-03	2.961
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.045379e-03	2.981
Separation of Sister Chromatids	R-HSA-2467813	1.135841e-03	2.945
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.140199e-03	2.943
ISG15 antiviral mechanism	R-HSA-1169408	1.295478e-03	2.888
Apoptotic execution phase	R-HSA-75153	1.374813e-03	2.862
HIV Infection	R-HSA-162906	1.439400e-03	2.842
Autophagy	R-HSA-9612973	1.480420e-03	2.830
Aggrephagy	R-HSA-9646399	1.876493e-03	2.727
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.173923e-03	2.663
Kinesins	R-HSA-983189	2.318021e-03	2.635
Cargo trafficking to the periciliary membrane	R-HSA-5620920	2.499824e-03	2.602
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	2.471659e-03	2.607
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.534120e-03	2.596
Cellular response to heat stress	R-HSA-3371556	2.619096e-03	2.582
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.882044e-03	2.540
HIV Life Cycle	R-HSA-162587	3.467039e-03	2.460
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.585177e-03	2.445
G1/S-Specific Transcription	R-HSA-69205	3.900005e-03	2.409
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.010604e-03	2.397
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.179518e-03	2.379
HCMV Early Events	R-HSA-9609690	4.016160e-03	2.396
Post NMDA receptor activation events	R-HSA-438064	4.418705e-03	2.355
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	4.486032e-03	2.348
Signaling by ALK in cancer	R-HSA-9700206	4.486032e-03	2.348
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.804733e-03	2.318
G alpha (12/13) signalling events	R-HSA-416482	4.853239e-03	2.314
Interleukin-37 signaling	R-HSA-9008059	5.347931e-03	2.272
Inactivation of CDC42 and RAC1	R-HSA-428543	5.431782e-03	2.265
Glycolysis	R-HSA-70171	5.882511e-03	2.230
Epigenetic regulation of gene expression	R-HSA-212165	6.079069e-03	2.216
Late Phase of HIV Life Cycle	R-HSA-162599	6.258538e-03	2.204
Gap junction trafficking and regulation	R-HSA-157858	6.482942e-03	2.188
Inositol phosphate metabolism	R-HSA-1483249	6.433541e-03	2.192
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	6.819470e-03	2.166
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	6.819470e-03	2.166
G0 and Early G1	R-HSA-1538133	7.089899e-03	2.149
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.224609e-03	2.141
Signal Transduction	R-HSA-162582	7.693206e-03	2.114
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	8.020583e-03	2.096
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.103722e-03	2.091
MTOR signalling	R-HSA-165159	9.254217e-03	2.034
G2/M Transition	R-HSA-69275	9.151775e-03	2.038
Amplification of signal from the kinetochores	R-HSA-141424	9.416879e-03	2.026
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	9.416879e-03	2.026
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	9.474693e-03	2.023
Sema4D in semaphorin signaling	R-HSA-400685	9.807003e-03	2.008
Mitotic G2-G2/M phases	R-HSA-453274	1.011142e-02	1.995
Gap junction assembly	R-HSA-190861	1.044584e-02	1.981
Cellular responses to stress	R-HSA-2262752	1.059605e-02	1.975
Homology Directed Repair	R-HSA-5693538	1.090835e-02	1.962
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.131820e-02	1.946
DNA Double-Strand Break Repair	R-HSA-5693532	1.172489e-02	1.931
Gap junction trafficking	R-HSA-190828	1.148913e-02	1.940
Cell Cycle Checkpoints	R-HSA-69620	1.213767e-02	1.916
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.236716e-02	1.908
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.292604e-02	1.889
RET signaling	R-HSA-8853659	1.324504e-02	1.878
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.436913e-02	1.843
SHC-related events triggered by IGF1R	R-HSA-2428933	1.436913e-02	1.843
MET activates RAS signaling	R-HSA-8851805	1.436913e-02	1.843
Mitotic Spindle Checkpoint	R-HSA-69618	1.361868e-02	1.866
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.482988e-02	1.829
MHC class II antigen presentation	R-HSA-2132295	1.475836e-02	1.831
Signaling by LTK	R-HSA-9842663	1.436913e-02	1.843
PKR-mediated signaling	R-HSA-9833482	1.446126e-02	1.840
HCMV Infection	R-HSA-9609646	1.530073e-02	1.815
Recycling pathway of L1	R-HSA-437239	1.555378e-02	1.808
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.556786e-02	1.808
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.564119e-02	1.806
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.601298e-02	1.796
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.839650e-02	1.735
Signaling by ALK	R-HSA-201556	1.839650e-02	1.735
Apoptosis	R-HSA-109581	1.856030e-02	1.731
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.901163e-02	1.721
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.062330e-02	1.686
RNA Polymerase II Transcription Termination	R-HSA-73856	2.004985e-02	1.698
Heme signaling	R-HSA-9707616	2.173207e-02	1.663
Glucose metabolism	R-HSA-70326	2.161889e-02	1.665
Gene Silencing by RNA	R-HSA-211000	2.247363e-02	1.648
PKMTs methylate histone lysines	R-HSA-3214841	2.252574e-02	1.647
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.266434e-02	1.645
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.266434e-02	1.645
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.266434e-02	1.645
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.266434e-02	1.645
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.266434e-02	1.645
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.266434e-02	1.645
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.266434e-02	1.645
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.266434e-02	1.645
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.266434e-02	1.645
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.266434e-02	1.645
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.266434e-02	1.645
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.503039e-02	1.602
mRNA 3'-end processing	R-HSA-72187	2.449184e-02	1.611
DCC mediated attractive signaling	R-HSA-418885	2.503039e-02	1.602
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.318631e-02	1.635
Adipogenesis	R-HSA-9843745	2.552202e-02	1.593
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.670795e-02	1.573
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.736547e-02	1.563
FOXO-mediated transcription	R-HSA-9614085	2.780885e-02	1.556
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.097912e-02	1.509
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.097912e-02	1.509
Regulation of TP53 Activity	R-HSA-5633007	3.146698e-02	1.502
Netrin-1 signaling	R-HSA-373752	3.261632e-02	1.487
ALK mutants bind TKIs	R-HSA-9700645	3.279597e-02	1.484
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.279597e-02	1.484
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.323446e-02	1.478
Signaling by MET	R-HSA-6806834	3.345672e-02	1.476
Signaling by NTRKs	R-HSA-166520	3.366105e-02	1.473
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.421530e-02	1.466
Processing of Intronless Pre-mRNAs	R-HSA-77595	3.421530e-02	1.466
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.478470e-02	1.459
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.478470e-02	1.459
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.478470e-02	1.459
Signal attenuation	R-HSA-74749	4.000865e-02	1.398
Processing of DNA double-strand break ends	R-HSA-5693607	3.566432e-02	1.448
Cilium Assembly	R-HSA-5617833	3.656019e-02	1.437
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.000865e-02	1.398
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	4.190706e-02	1.378
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	4.208533e-02	1.376
mRNA Splicing - Major Pathway	R-HSA-72163	4.269458e-02	1.370
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.355126e-02	1.361
Signaling by NTRK2 (TRKB)	R-HSA-9006115	4.355126e-02	1.361
Gene expression (Transcription)	R-HSA-74160	4.506105e-02	1.346
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.511550e-02	1.346
Polo-like kinase mediated events	R-HSA-156711	4.511550e-02	1.346
Signaling by ERBB2	R-HSA-1227986	4.537655e-02	1.343
Cellular responses to stimuli	R-HSA-8953897	4.610487e-02	1.336
Regulation of HMOX1 expression and activity	R-HSA-9707587	4.732984e-02	1.325
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.732984e-02	1.325
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.732984e-02	1.325
Activated NTRK3 signals through RAS	R-HSA-9034864	4.795284e-02	1.319
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.838255e-02	1.315
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	5.582571e-02	1.253
Activated NTRK2 signals through RAS	R-HSA-9026519	5.660700e-02	1.247
Activation of the pre-replicative complex	R-HSA-68962	5.878239e-02	1.231
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.878239e-02	1.231
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.878239e-02	1.231
Activation of RAC1	R-HSA-428540	5.660700e-02	1.247
HATs acetylate histones	R-HSA-3214847	5.658157e-02	1.247
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	5.773382e-02	1.239
Nuclear signaling by ERBB4	R-HSA-1251985	5.644612e-02	1.248
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	5.878239e-02	1.231
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.020046e-02	1.220
Organelle biogenesis and maintenance	R-HSA-1852241	6.087029e-02	1.216
SMAC (DIABLO) binds to IAPs	R-HSA-111463	6.208064e-02	1.207
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	6.208064e-02	1.207
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	6.208064e-02	1.207
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	6.208064e-02	1.207
mRNA Splicing	R-HSA-72172	6.334209e-02	1.198
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	6.445462e-02	1.191
Signalling to RAS	R-HSA-167044	6.467878e-02	1.189
Zygotic genome activation (ZGA)	R-HSA-9819196	6.467878e-02	1.189
G1/S Transition	R-HSA-69206	6.499062e-02	1.187
p75NTR recruits signalling complexes	R-HSA-209543	6.594513e-02	1.181
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	6.594513e-02	1.181
Interleukin-15 signaling	R-HSA-8983432	6.594513e-02	1.181
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	7.815384e-02	1.107
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	7.815384e-02	1.107
CDC6 association with the ORC:origin complex	R-HSA-68689	7.815384e-02	1.107
Signaling by RNF43 mutants	R-HSA-5340588	7.815384e-02	1.107
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.203923e-02	1.142
Diseases of mitotic cell cycle	R-HSA-9675126	7.042272e-02	1.152
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.703520e-02	1.174
PPARA activates gene expression	R-HSA-1989781	7.913564e-02	1.102
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.203923e-02	1.142
Formation of lateral plate mesoderm	R-HSA-9758920	7.815384e-02	1.107
mTORC1-mediated signalling	R-HSA-166208	7.980674e-02	1.098
Regulation of CDH19 Expression and Function	R-HSA-9764302	7.815384e-02	1.107
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.668425e-02	1.115
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	7.815384e-02	1.107
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	7.593758e-02	1.120
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.203923e-02	1.142
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	7.815384e-02	1.107
Signaling by PDGFR in disease	R-HSA-9671555	7.203923e-02	1.142
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.445335e-02	1.128
Signaling by SCF-KIT	R-HSA-1433557	7.666985e-02	1.115
Transcriptional Regulation by TP53	R-HSA-3700989	7.655549e-02	1.116
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	7.545982e-02	1.122
Axon guidance	R-HSA-422475	8.051719e-02	1.094
Regulation of CDH1 Gene Transcription	R-HSA-9764560	8.449322e-02	1.073
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.507374e-02	1.070
HCMV Late Events	R-HSA-9610379	8.507374e-02	1.070
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	8.655179e-02	1.063
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.797131e-02	1.056
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.965068e-02	1.047
Nervous system development	R-HSA-9675108	8.978661e-02	1.047
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	9.007358e-02	1.045
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	9.507719e-02	1.022
G2/M DNA replication checkpoint	R-HSA-69478	9.535615e-02	1.021
Regulation of NFE2L2 gene expression	R-HSA-9818749	9.535615e-02	1.021
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	R-HSA-210746	9.535615e-02	1.021
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	9.652158e-02	1.015
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	9.719232e-02	1.012
Signalling to ERKs	R-HSA-187687	9.719232e-02	1.012
p75NTR signals via NF-kB	R-HSA-193639	9.775290e-02	1.010
Cell-extracellular matrix interactions	R-HSA-446353	9.775290e-02	1.010
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.085381e-01	0.964
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.085381e-01	0.964
Diseases of Telomere Maintenance	R-HSA-9673013	1.085381e-01	0.964
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.085381e-01	0.964
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.085381e-01	0.964
Recycling of eIF2:GDP	R-HSA-72731	1.135117e-01	0.945
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.095044e-01	0.961
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.185455e-01	0.926
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.185455e-01	0.926
Regulation of endogenous retroelements	R-HSA-9842860	1.210911e-01	0.917
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.147275e-01	0.940
TRAF6 mediated IRF7 activation	R-HSA-933541	1.122497e-01	0.950
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.217685e-01	0.914
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.043757e-01	0.981
Intraflagellar transport	R-HSA-5620924	1.069735e-01	0.971
Regulation of PTEN localization	R-HSA-8948747	1.135117e-01	0.945
S Phase	R-HSA-69242	1.029459e-01	0.987
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.174267e-01	0.930
G2/M DNA damage checkpoint	R-HSA-69473	1.043757e-01	0.981
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.217685e-01	0.914
G2/M Checkpoints	R-HSA-69481	1.226166e-01	0.911
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.069735e-01	0.971
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.124183e-01	0.949
Signaling by ERBB4	R-HSA-1236394	1.043757e-01	0.981
Signaling by PTK6	R-HSA-8848021	1.185455e-01	0.926
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.185455e-01	0.926
Cellular Senescence	R-HSA-2559583	1.160374e-01	0.935
Programmed Cell Death	R-HSA-5357801	1.038990e-01	0.983
MECP2 regulates transcription factors	R-HSA-9022707	1.135117e-01	0.945
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	1.243547e-01	0.905
HDMs demethylate histones	R-HSA-3214842	1.054449e-01	0.977
Transcriptional Regulation by MECP2	R-HSA-8986944	1.268500e-01	0.897
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.270430e-01	0.896
SARS-CoV-2-host interactions	R-HSA-9705683	1.297310e-01	0.887
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.298435e-01	0.887
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	1.583106e-01	0.800
Intestinal infectious diseases	R-HSA-8942233	1.583106e-01	0.800
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	1.583106e-01	0.800
Signaling by TCF7L2 mutants	R-HSA-5339700	1.583106e-01	0.800
Defective F8 sulfation at Y1699	R-HSA-9674519	2.053070e-01	0.688
MET activates STAT3	R-HSA-8875791	2.496820e-01	0.603
Classical Kir channels	R-HSA-1296053	2.496820e-01	0.603
Signalling to STAT3	R-HSA-198745	2.496820e-01	0.603
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.496820e-01	0.603
Defective DPM2 causes DPM2-CDG	R-HSA-4719377	2.496820e-01	0.603
Defective DPM3 causes DPM3-CDG	R-HSA-4719360	2.496820e-01	0.603
Defective DPM1 causes DPM1-CDG	R-HSA-4717374	2.496820e-01	0.603
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.496820e-01	0.603
ROBO receptors bind AKAP5	R-HSA-9010642	1.324608e-01	0.878
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.520585e-01	0.818
HCN channels	R-HSA-1296061	2.915817e-01	0.535
TNFR1-mediated ceramide production	R-HSA-5626978	2.915817e-01	0.535
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.915817e-01	0.535
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.915817e-01	0.535
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.915817e-01	0.535
Defective LFNG causes SCDO3	R-HSA-5083630	2.915817e-01	0.535
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.915817e-01	0.535
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	1.345066e-01	0.871
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.134922e-01	0.671
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.476800e-01	0.831
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	1.476800e-01	0.831
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.344926e-01	0.630
Repression of WNT target genes	R-HSA-4641265	2.344926e-01	0.630
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.684991e-01	0.434
Phosphorylation of Emi1	R-HSA-176417	3.684991e-01	0.434
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.684991e-01	0.434
CD28 dependent Vav1 pathway	R-HSA-389359	2.556018e-01	0.592
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.556018e-01	0.592
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.556018e-01	0.592
SHC-mediated cascade:FGFR3	R-HSA-5654704	1.894233e-01	0.723
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.445798e-01	0.840
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.445798e-01	0.840
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.551446e-01	0.809
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.551446e-01	0.809
SHC-mediated cascade:FGFR4	R-HSA-5654719	2.039517e-01	0.690
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	2.039517e-01	0.690
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	4.037701e-01	0.394
Autointegration results in viral DNA circles	R-HSA-177539	4.037701e-01	0.394
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	4.037701e-01	0.394
Defective CHST3 causes SEDCJD	R-HSA-3595172	4.037701e-01	0.394
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	4.037701e-01	0.394
Notch-HLH transcription pathway	R-HSA-350054	2.187252e-01	0.660
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.187252e-01	0.660
Processive synthesis on the lagging strand	R-HSA-69183	2.978445e-01	0.526
SHC1 events in EGFR signaling	R-HSA-180336	2.978445e-01	0.526
Interleukin receptor SHC signaling	R-HSA-912526	2.337082e-01	0.631
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.634470e-01	0.787
Striated Muscle Contraction	R-HSA-390522	2.000096e-01	0.699
SHC-mediated cascade:FGFR1	R-HSA-5654688	2.488663e-01	0.604
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.188474e-01	0.496
Class I peroxisomal membrane protein import	R-HSA-9603798	3.188474e-01	0.496
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.188474e-01	0.496
Phase 4 - resting membrane potential	R-HSA-5576886	3.188474e-01	0.496
RUNX3 regulates WNT signaling	R-HSA-8951430	4.370731e-01	0.359
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	4.370731e-01	0.359
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.370731e-01	0.359
Defective CHSY1 causes TPBS	R-HSA-3595177	4.370731e-01	0.359
SOS-mediated signalling	R-HSA-112412	4.370731e-01	0.359
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	4.370731e-01	0.359
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	4.370731e-01	0.359
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	4.370731e-01	0.359
SHC1 events in ERBB4 signaling	R-HSA-1250347	3.396960e-01	0.469
GRB2 events in ERBB2 signaling	R-HSA-1963640	3.396960e-01	0.469
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.396960e-01	0.469
AURKA Activation by TPX2	R-HSA-8854518	1.379308e-01	0.860
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.919937e-01	0.717
Nucleosome assembly	R-HSA-774815	1.919937e-01	0.717
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.358877e-01	0.627
SHC-mediated cascade:FGFR2	R-HSA-5654699	2.950655e-01	0.530
Packaging Of Telomere Ends	R-HSA-171306	2.950655e-01	0.530
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.603423e-01	0.443
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	4.685179e-01	0.329
Signaling by MRAS-complex mutants	R-HSA-9660537	4.685179e-01	0.329
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.685179e-01	0.329
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.000185e-01	0.699
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.106050e-01	0.508
RNA Polymerase III Transcription Termination	R-HSA-73980	3.807439e-01	0.419
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.885611e-01	0.725
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.857684e-01	0.544
Centrosome maturation	R-HSA-380287	2.042623e-01	0.690
Formation of RNA Pol II elongation complex	R-HSA-112382	2.643115e-01	0.578
Pre-NOTCH Processing in Golgi	R-HSA-1912420	4.008637e-01	0.397
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.008637e-01	0.397
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.008637e-01	0.397
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.751333e-01	0.560
Regulation of PD-L1(CD274) translation	R-HSA-9909620	4.206696e-01	0.376
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.206696e-01	0.376
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.206696e-01	0.376
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.206696e-01	0.376
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.206696e-01	0.376
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.401340e-01	0.356
Switching of origins to a post-replicative state	R-HSA-69052	3.232279e-01	0.490
Dual Incision in GG-NER	R-HSA-5696400	4.186503e-01	0.378
HSF1-dependent transactivation	R-HSA-3371571	4.394191e-01	0.357
Orc1 removal from chromatin	R-HSA-68949	4.519747e-01	0.345
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.065789e-01	0.295
Attenuation phase	R-HSA-3371568	5.065789e-01	0.295
HDACs deacetylate histones	R-HSA-3214815	4.890482e-01	0.311
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.011785e-01	0.300
Signaling by NOTCH2	R-HSA-1980145	4.186503e-01	0.378
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	4.401340e-01	0.356
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.556018e-01	0.592
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.136195e-01	0.670
RNA Polymerase III Transcription	R-HSA-74158	2.358877e-01	0.627
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.751333e-01	0.560
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.132756e-01	0.504
Chromosome Maintenance	R-HSA-73886	1.596604e-01	0.797
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.134922e-01	0.671
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.396960e-01	0.469
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.733782e-01	0.761
Telomere Maintenance	R-HSA-157579	4.265066e-01	0.370
DNA Replication Pre-Initiation	R-HSA-69002	2.639732e-01	0.578
Regulation of the apoptosome activity	R-HSA-9627069	1.721734e-01	0.764
Cytochrome c-mediated apoptotic response	R-HSA-111461	2.134922e-01	0.671
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	1.543360e-01	0.812
Extension of Telomeres	R-HSA-180786	3.415635e-01	0.467
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.221399e-01	0.653
Formation of apoptosome	R-HSA-111458	1.721734e-01	0.764
VxPx cargo-targeting to cilium	R-HSA-5620916	1.751768e-01	0.757
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	2.187252e-01	0.660
Regulation of CDH11 function	R-HSA-9762292	5.262412e-01	0.279
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	4.592332e-01	0.338
Transcription of the HIV genome	R-HSA-167172	4.423855e-01	0.354
Mitophagy	R-HSA-5205647	2.117870e-01	0.674
Assembly of the pre-replicative complex	R-HSA-68867	2.441471e-01	0.612
Synthesis of DNA	R-HSA-69239	2.492004e-01	0.603
FRS-mediated FGFR3 signaling	R-HSA-5654706	4.592332e-01	0.338
FRS-mediated FGFR4 signaling	R-HSA-5654712	4.779474e-01	0.321
RNA Polymerase III Transcription Initiation	R-HSA-76046	3.417258e-01	0.466
Resolution of D-Loop Structures	R-HSA-5693537	4.034516e-01	0.394
Cyclin D associated events in G1	R-HSA-69231	3.498554e-01	0.456
G1 Phase	R-HSA-69236	3.498554e-01	0.456
Signaling by FGFR4	R-HSA-5654743	1.727671e-01	0.763
NTRK3 as a dependence receptor	R-HSA-9603505	1.583106e-01	0.800
Regulation of gap junction activity	R-HSA-191650	2.915817e-01	0.535
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	3.684991e-01	0.434
Erythropoietin activates RAS	R-HSA-9027284	2.978445e-01	0.526
Telomere C-strand synthesis initiation	R-HSA-174430	2.978445e-01	0.526
E2F mediated regulation of DNA replication	R-HSA-113510	4.008637e-01	0.397
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	4.982080e-01	0.303
Gap junction degradation	R-HSA-190873	4.982080e-01	0.303
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.881401e-01	0.411
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.065789e-01	0.295
Activation of HOX genes during differentiation	R-HSA-5619507	1.362990e-01	0.866
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.362990e-01	0.866
Downstream signaling of activated FGFR3	R-HSA-5654708	1.445798e-01	0.840
Downstream signaling of activated FGFR4	R-HSA-5654716	1.551446e-01	0.809
Downstream signaling of activated FGFR2	R-HSA-5654696	2.237524e-01	0.650
Signaling by FGFR2	R-HSA-5654738	3.937079e-01	0.405
Assembly of the ORC complex at the origin of replication	R-HSA-68616	3.881401e-01	0.411
Lagging Strand Synthesis	R-HSA-69186	4.401340e-01	0.356
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.140710e-01	0.383
Signaling by FGFR3	R-HSA-5654741	1.919937e-01	0.717
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	2.344926e-01	0.630
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.344926e-01	0.630
Apoptotic factor-mediated response	R-HSA-111471	3.807439e-01	0.419
Downstream signaling of activated FGFR1	R-HSA-5654687	2.237524e-01	0.650
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.287077e-01	0.277
Signaling by FGFR1	R-HSA-5654736	1.661708e-01	0.779
Signaling by FGFR1 in disease	R-HSA-5655302	1.543360e-01	0.812
Signaling by FGFR	R-HSA-190236	4.357245e-01	0.361
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.528221e-01	0.597
TGFBR3 PTM regulation	R-HSA-9839383	1.324608e-01	0.878
Calcineurin activates NFAT	R-HSA-2025928	1.520585e-01	0.818
PTK6 Activates STAT3	R-HSA-8849474	3.311439e-01	0.480
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	3.311439e-01	0.480
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.311439e-01	0.480
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	2.134922e-01	0.671
Cardiogenesis	R-HSA-9733709	1.884384e-01	0.725
PTK6 Expression	R-HSA-8849473	4.370731e-01	0.359
Polymerase switching on the C-strand of the telomere	R-HSA-174411	2.641663e-01	0.578
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.396960e-01	0.469
Metalloprotease DUBs	R-HSA-5689901	2.795762e-01	0.553
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	4.685179e-01	0.329
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.580586e-01	0.801
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.241031e-01	0.489
DNA strand elongation	R-HSA-69190	3.727348e-01	0.429
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.262412e-01	0.279
Meiotic synapsis	R-HSA-1221632	4.644376e-01	0.333
DNA Replication	R-HSA-69306	2.825443e-01	0.549
Cellular response to hypoxia	R-HSA-1234174	4.089588e-01	0.388
DAP12 signaling	R-HSA-2424491	3.417258e-01	0.466
Ephrin signaling	R-HSA-3928664	3.807439e-01	0.419
Neurexins and neuroligins	R-HSA-6794361	1.350306e-01	0.870
trans-Golgi Network Vesicle Budding	R-HSA-199992	3.132756e-01	0.504
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.556018e-01	0.592
DNA Double Strand Break Response	R-HSA-5693606	1.447163e-01	0.839
Lysosome Vesicle Biogenesis	R-HSA-432720	4.486402e-01	0.348
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.312858e-01	0.365
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.516579e-01	0.819
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	1.324608e-01	0.878
Activation of C3 and C5	R-HSA-174577	3.311439e-01	0.480
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	2.187252e-01	0.660
MET promotes cell motility	R-HSA-8875878	4.779848e-01	0.321
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.055039e-01	0.296
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.134922e-01	0.671
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.857684e-01	0.544
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.857684e-01	0.544
Downregulation of ERBB2 signaling	R-HSA-8863795	3.417258e-01	0.466
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.751333e-01	0.560
Circadian clock	R-HSA-9909396	2.360398e-01	0.627
FGFR1 mutant receptor activation	R-HSA-1839124	3.881401e-01	0.411
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.982080e-01	0.303
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	4.779474e-01	0.321
TNF signaling	R-HSA-75893	3.080914e-01	0.511
TCF dependent signaling in response to WNT	R-HSA-201681	1.920637e-01	0.717
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	1.583106e-01	0.800
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	2.053070e-01	0.688
MET interacts with TNS proteins	R-HSA-8875513	2.496820e-01	0.603
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.520585e-01	0.818
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.915817e-01	0.535
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	3.311439e-01	0.480
NTRK2 activates RAC1	R-HSA-9032759	3.311439e-01	0.480
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.134922e-01	0.671
NF-kB is activated and signals survival	R-HSA-209560	2.134922e-01	0.671
Synthesis of dolichyl-phosphate mannose	R-HSA-162699	3.684991e-01	0.434
Noncanonical activation of NOTCH3	R-HSA-9017802	3.684991e-01	0.434
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.556018e-01	0.592
Intracellular metabolism of fatty acids regulates insulin secretion	R-HSA-434313	4.037701e-01	0.394
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	3.188474e-01	0.496
Netrin mediated repulsion signals	R-HSA-418886	4.370731e-01	0.359
Disinhibition of SNARE formation	R-HSA-114516	4.370731e-01	0.359
Cohesin Loading onto Chromatin	R-HSA-2470946	4.370731e-01	0.359
Regulation of FZD by ubiquitination	R-HSA-4641263	3.603423e-01	0.443
Interleukin-23 signaling	R-HSA-9020933	4.685179e-01	0.329
Type I hemidesmosome assembly	R-HSA-446107	4.685179e-01	0.329
Formation of annular gap junctions	R-HSA-196025	4.685179e-01	0.329
FGFR1b ligand binding and activation	R-HSA-190370	4.685179e-01	0.329
MET receptor recycling	R-HSA-8875656	4.685179e-01	0.329
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.807439e-01	0.419
Unwinding of DNA	R-HSA-176974	4.982080e-01	0.303
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.262412e-01	0.279
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.262412e-01	0.279
DNA replication initiation	R-HSA-68952	5.262412e-01	0.279
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.141574e-01	0.289
Deadenylation of mRNA	R-HSA-429947	5.141574e-01	0.289
TRAF6 mediated NF-kB activation	R-HSA-933542	5.141574e-01	0.289
Estrogen-dependent gene expression	R-HSA-9018519	2.686042e-01	0.571
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.795762e-01	0.553
DNA Damage Bypass	R-HSA-73893	4.140710e-01	0.383
IGF1R signaling cascade	R-HSA-2428924	3.977476e-01	0.400
Signaling by FGFR4 in disease	R-HSA-5655291	2.767421e-01	0.558
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.984865e-01	0.525
Regulation of TNFR1 signaling	R-HSA-5357905	2.018791e-01	0.695
Pexophagy	R-HSA-9664873	1.721734e-01	0.764
Integrin signaling	R-HSA-354192	3.881401e-01	0.411
Signaling by FGFR in disease	R-HSA-1226099	5.076297e-01	0.294
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.378927e-01	0.359
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.661708e-01	0.779
Termination of translesion DNA synthesis	R-HSA-5656169	3.261672e-01	0.487
Interleukin-2 family signaling	R-HSA-451927	2.857684e-01	0.544
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.039517e-01	0.690
NRIF signals cell death from the nucleus	R-HSA-205043	2.767421e-01	0.558
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.978445e-01	0.526
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.978445e-01	0.526
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.117870e-01	0.674
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.685179e-01	0.329
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.089588e-01	0.388
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.984865e-01	0.525
Evasion by RSV of host interferon responses	R-HSA-9833109	1.659878e-01	0.780
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.807439e-01	0.419
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	5.182174e-01	0.285
Signaling by NOTCH1	R-HSA-1980143	5.287077e-01	0.277
NGF-stimulated transcription	R-HSA-9031628	4.013002e-01	0.397
Interleukin-27 signaling	R-HSA-9020956	1.721734e-01	0.764
Signaling by Hippo	R-HSA-2028269	1.345066e-01	0.871
p38MAPK events	R-HSA-171007	2.978445e-01	0.526
Interleukin-21 signaling	R-HSA-9020958	4.982080e-01	0.303
Formation of intermediate mesoderm	R-HSA-9761174	5.262412e-01	0.279
Deadenylation-dependent mRNA decay	R-HSA-429914	3.415635e-01	0.467
Mitochondrial calcium ion transport	R-HSA-8949215	4.592332e-01	0.338
GPER1 signaling	R-HSA-9634597	4.013002e-01	0.397
Protein-protein interactions at synapses	R-HSA-6794362	1.708958e-01	0.767
Protein folding	R-HSA-391251	3.710147e-01	0.431
Interleukin-9 signaling	R-HSA-8985947	4.685179e-01	0.329
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.950655e-01	0.530
Hedgehog 'off' state	R-HSA-5610787	3.089102e-01	0.510
EPH-Ephrin signaling	R-HSA-2682334	3.710147e-01	0.431
RAF/MAP kinase cascade	R-HSA-5673001	4.141199e-01	0.383
DNA Repair	R-HSA-73894	3.475765e-01	0.459
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.623994e-01	0.335
Metabolism of RNA	R-HSA-8953854	2.148447e-01	0.668
Cytoprotection by HMOX1	R-HSA-9707564	2.714147e-01	0.566
MAPK1/MAPK3 signaling	R-HSA-5684996	4.521076e-01	0.345
Breakdown of the nuclear lamina	R-HSA-352238	1.583106e-01	0.800
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.520585e-01	0.818
Cellular response to mitochondrial stress	R-HSA-9840373	1.520585e-01	0.818
IRS activation	R-HSA-74713	3.311439e-01	0.480
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	2.134922e-01	0.671
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.767421e-01	0.558
Integration of viral DNA into host genomic DNA	R-HSA-175567	4.037701e-01	0.394
VLDL clearance	R-HSA-8964046	4.370731e-01	0.359
Disorders of Developmental Biology	R-HSA-9675151	3.396960e-01	0.469
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	3.396960e-01	0.469
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.603423e-01	0.443
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.603423e-01	0.443
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.641813e-01	0.785
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.807439e-01	0.419
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.401340e-01	0.356
TNFR1-induced proapoptotic signaling	R-HSA-5357786	4.401340e-01	0.356
EGFR Transactivation by Gastrin	R-HSA-2179392	5.262412e-01	0.279
2-LTR circle formation	R-HSA-164843	5.262412e-01	0.279
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.141574e-01	0.289
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.861845e-01	0.313
ESR-mediated signaling	R-HSA-8939211	5.105052e-01	0.292
Semaphorin interactions	R-HSA-373755	2.269203e-01	0.644
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	2.187252e-01	0.660
RNA Polymerase II Transcription	R-HSA-73857	4.526840e-01	0.344
MAPK family signaling cascades	R-HSA-5683057	2.210018e-01	0.656
Formation of definitive endoderm	R-HSA-9823730	1.751768e-01	0.757
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	2.337082e-01	0.631
Tie2 Signaling	R-HSA-210993	1.476800e-01	0.831
Receptor Mediated Mitophagy	R-HSA-8934903	5.262412e-01	0.279
Muscle contraction	R-HSA-397014	4.630839e-01	0.334
Early Phase of HIV Life Cycle	R-HSA-162594	4.401340e-01	0.356
Transcriptional regulation by RUNX1	R-HSA-8878171	2.542435e-01	0.595
Signaling by Interleukins	R-HSA-449147	4.636303e-01	0.334
Cell-Cell communication	R-HSA-1500931	4.670629e-01	0.331
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.128088e-01	0.290
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.873589e-01	0.727
Activation of BH3-only proteins	R-HSA-114452	3.417258e-01	0.466
Signaling by Leptin	R-HSA-2586552	5.262412e-01	0.279
Chaperonin-mediated protein folding	R-HSA-390466	3.160146e-01	0.500
Signaling by TGFBR3	R-HSA-9839373	2.018791e-01	0.695
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.401340e-01	0.356
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.401340e-01	0.356
Signaling by EGFR	R-HSA-177929	3.080914e-01	0.511
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.752723e-01	0.426
RSV-host interactions	R-HSA-9833110	3.510826e-01	0.455
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.520585e-01	0.818
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	3.311439e-01	0.480
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.556018e-01	0.592
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	3.188474e-01	0.496
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	4.370731e-01	0.359
Phase 3 - rapid repolarisation	R-HSA-5576890	4.370731e-01	0.359
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	2.731324e-01	0.564
Downstream signal transduction	R-HSA-186763	3.572561e-01	0.447
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.881401e-01	0.411
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.519747e-01	0.345
MAPK6/MAPK4 signaling	R-HSA-5687128	4.440253e-01	0.353
Mitochondrial biogenesis	R-HSA-1592230	4.793332e-01	0.319
Deubiquitination	R-HSA-5688426	4.137033e-01	0.383
Signaling by NOTCH3	R-HSA-9012852	1.581160e-01	0.801
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.527867e-01	0.452
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.491448e-01	0.457
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	2.795762e-01	0.553
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	3.432558e-01	0.464
Cytokine Signaling in Immune system	R-HSA-1280215	2.699976e-01	0.569
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.846870e-01	0.734
Regulation of beta-cell development	R-HSA-186712	3.415635e-01	0.467
Signaling by KIT in disease	R-HSA-9669938	4.779474e-01	0.321
Transcriptional Regulation by VENTX	R-HSA-8853884	5.205668e-01	0.284
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.822862e-01	0.739
Base Excision Repair	R-HSA-73884	3.433804e-01	0.464
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.344926e-01	0.630
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.603423e-01	0.443
Azathioprine ADME	R-HSA-9748787	2.429804e-01	0.614
Activation of ATR in response to replication stress	R-HSA-176187	3.881401e-01	0.411
Golgi-to-ER retrograde transport	R-HSA-8856688	2.360398e-01	0.627
Cleavage of the damaged purine	R-HSA-110331	4.634002e-01	0.334
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	4.038081e-01	0.394
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.187252e-01	0.660
Regulation of MECP2 expression and activity	R-HSA-9022692	3.881401e-01	0.411
Formation of the ureteric bud	R-HSA-9830674	4.962600e-01	0.304
Depurination	R-HSA-73927	4.779848e-01	0.321
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.905093e-01	0.309
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.324608e-01	0.878
Nef and signal transduction	R-HSA-164944	4.037701e-01	0.394
HDL clearance	R-HSA-8964011	4.037701e-01	0.394
Synthesis of PG	R-HSA-1483148	3.396960e-01	0.469
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.603423e-01	0.443
Regulated proteolysis of p75NTR	R-HSA-193692	4.982080e-01	0.303
Lipophagy	R-HSA-9613354	4.982080e-01	0.303
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.982080e-01	0.303
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.727348e-01	0.429
MET activates RAP1 and RAC1	R-HSA-8875555	5.262412e-01	0.279
Complex III assembly	R-HSA-9865881	5.141574e-01	0.289
Interleukin-12 family signaling	R-HSA-447115	1.917568e-01	0.717
Interleukin-35 Signalling	R-HSA-8984722	2.344926e-01	0.630
Interleukin-7 signaling	R-HSA-1266695	2.641663e-01	0.578
CD209 (DC-SIGN) signaling	R-HSA-5621575	5.141574e-01	0.289
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	3.188474e-01	0.496
Activated NTRK2 signals through CDK5	R-HSA-9032845	4.370731e-01	0.359
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.743950e-01	0.758
Tandem pore domain potassium channels	R-HSA-1296346	5.262412e-01	0.279
NOD1/2 Signaling Pathway	R-HSA-168638	4.186503e-01	0.378
COPI-mediated anterograde transport	R-HSA-6807878	4.172716e-01	0.380
FLT3 Signaling	R-HSA-9607240	5.205668e-01	0.284
Unfolded Protein Response (UPR)	R-HSA-381119	4.074357e-01	0.390
Formation of the nephric duct	R-HSA-9830364	2.641663e-01	0.578
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.861845e-01	0.313
ChREBP activates metabolic gene expression	R-HSA-163765	1.926870e-01	0.715
Nephrin family interactions	R-HSA-373753	1.751768e-01	0.757
TNFs bind their physiological receptors	R-HSA-5669034	5.141574e-01	0.289
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.311439e-01	0.480
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.684991e-01	0.434
Activated NTRK2 signals through FYN	R-HSA-9032500	4.685179e-01	0.329
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	2.269203e-01	0.644
RMTs methylate histone arginines	R-HSA-3214858	3.498554e-01	0.456
Influenza Infection	R-HSA-168255	1.731949e-01	0.761
Syndecan interactions	R-HSA-3000170	4.962600e-01	0.304
Nectin/Necl trans heterodimerization	R-HSA-420597	3.311439e-01	0.480
Defective factor VIII causes hemophilia A	R-HSA-9662001	4.037701e-01	0.394
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	3.396960e-01	0.469
Butyrophilin (BTN) family interactions	R-HSA-8851680	4.982080e-01	0.303
Signaling by WNT in cancer	R-HSA-4791275	3.727348e-01	0.429
Maturation of spike protein	R-HSA-9683686	5.262412e-01	0.279
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.011785e-01	0.300
Interferon Signaling	R-HSA-913531	1.814660e-01	0.741
Mismatch Repair	R-HSA-5358508	3.807439e-01	0.419
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	3.836019e-01	0.416
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.894233e-01	0.723
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.396960e-01	0.469
L1CAM interactions	R-HSA-373760	2.191833e-01	0.659
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.770917e-01	0.752
Plasma lipoprotein assembly	R-HSA-8963898	5.141574e-01	0.289
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	4.685179e-01	0.329
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.982080e-01	0.303
SARS-CoV-2 Infection	R-HSA-9694516	2.287891e-01	0.641
Replication of the SARS-CoV-1 genome	R-HSA-9682706	2.556018e-01	0.592
SARS-CoV Infections	R-HSA-9679506	4.600105e-01	0.337
Replication of the SARS-CoV-2 genome	R-HSA-9694686	3.603423e-01	0.443
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.807439e-01	0.419
Neurodegenerative Diseases	R-HSA-8863678	5.141574e-01	0.289
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	5.141574e-01	0.289
NPAS4 regulates expression of target genes	R-HSA-9768919	4.186503e-01	0.378
XBP1(S) activates chaperone genes	R-HSA-381038	1.846870e-01	0.734
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.454670e-01	0.610
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	5.141574e-01	0.289
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	2.767421e-01	0.558
IRE1alpha activates chaperones	R-HSA-381070	2.287001e-01	0.641
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	4.008637e-01	0.397
tRNA processing	R-HSA-72306	1.344353e-01	0.871
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	3.188474e-01	0.496
Differentiation of T cells	R-HSA-9945266	3.188474e-01	0.496
Assembly of Viral Components at the Budding Site	R-HSA-168316	3.311439e-01	0.480
Maturation of replicase proteins	R-HSA-9694301	4.370731e-01	0.359
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	4.186503e-01	0.378
Interleukin-12 signaling	R-HSA-9020591	3.533168e-01	0.452
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	4.186503e-01	0.378
SLC transporter disorders	R-HSA-5619102	3.760311e-01	0.425
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.292279e-01	0.276
Signaling by Nuclear Receptors	R-HSA-9006931	5.294276e-01	0.276
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.316290e-01	0.274
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.316290e-01	0.274
Glycogen breakdown (glycogenolysis)	R-HSA-70221	5.316290e-01	0.274
TGFBR3 expression	R-HSA-9839394	5.316290e-01	0.274
HIV Transcription Initiation	R-HSA-167161	5.343361e-01	0.272
RNA Polymerase II Transcription Initiation	R-HSA-75953	5.343361e-01	0.272
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	5.343361e-01	0.272
Stimuli-sensing channels	R-HSA-2672351	5.347511e-01	0.272
Regulation of PD-L1(CD274) expression	R-HSA-9909648	5.374059e-01	0.270
Cell junction organization	R-HSA-446728	5.445753e-01	0.264
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	5.478785e-01	0.261
Cleavage of the damaged pyrimidine	R-HSA-110329	5.478785e-01	0.261
Depyrimidination	R-HSA-73928	5.478785e-01	0.261
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	5.483572e-01	0.261
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	5.483572e-01	0.261
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	5.483572e-01	0.261
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	5.483572e-01	0.261
Signaling by NOTCH1 in Cancer	R-HSA-2644603	5.483572e-01	0.261
Regulation of PTEN gene transcription	R-HSA-8943724	5.483572e-01	0.261
Glutathione conjugation	R-HSA-156590	5.483572e-01	0.261
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.486664e-01	0.261
Signaling by EGFR in Cancer	R-HSA-1643713	5.486664e-01	0.261
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	5.486664e-01	0.261
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.486664e-01	0.261
RNA Polymerase I Transcription	R-HSA-73864	5.493762e-01	0.260
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.493762e-01	0.260
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.527098e-01	0.258
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.527098e-01	0.258
Regulation of localization of FOXO transcription factors	R-HSA-9614399	5.527098e-01	0.258
RHOBTB3 ATPase cycle	R-HSA-9706019	5.527098e-01	0.258
Bicarbonate transporters	R-HSA-425381	5.527098e-01	0.258
Transport of RCbl within the body	R-HSA-9758890	5.527098e-01	0.258
Chylomicron assembly	R-HSA-8963888	5.527098e-01	0.258
Suppression of apoptosis	R-HSA-9635465	5.527098e-01	0.258
Interleukin-2 signaling	R-HSA-9020558	5.527098e-01	0.258
Signaling by VEGF	R-HSA-194138	5.535155e-01	0.257
Signaling by WNT	R-HSA-195721	5.572883e-01	0.254
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	5.599034e-01	0.252
RNA Polymerase II Promoter Escape	R-HSA-73776	5.611869e-01	0.251
TBC/RABGAPs	R-HSA-8854214	5.611869e-01	0.251
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.652636e-01	0.248
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.652636e-01	0.248
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.652636e-01	0.248
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.652636e-01	0.248
RNA Polymerase I Transcription Termination	R-HSA-73863	5.652636e-01	0.248
Signaling by FGFR3 in disease	R-HSA-5655332	5.652636e-01	0.248
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	5.652636e-01	0.248
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	5.652636e-01	0.248
Insulin processing	R-HSA-264876	5.652636e-01	0.248
Viral Infection Pathways	R-HSA-9824446	5.662365e-01	0.247
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.710521e-01	0.243
EPHB-mediated forward signaling	R-HSA-3928662	5.742550e-01	0.241
DAP12 interactions	R-HSA-2172127	5.742550e-01	0.241
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.774664e-01	0.238
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.777012e-01	0.238
DS-GAG biosynthesis	R-HSA-2022923	5.777012e-01	0.238
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.777012e-01	0.238
Integration of provirus	R-HSA-162592	5.777012e-01	0.238
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.777012e-01	0.238
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	5.777012e-01	0.238
Reduction of cytosolic Ca++ levels	R-HSA-418359	5.777012e-01	0.238
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.777012e-01	0.238
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.777012e-01	0.238
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.777012e-01	0.238
Synthesis of diphthamide-EEF2	R-HSA-5358493	5.777012e-01	0.238
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.814167e-01	0.236
HIV elongation arrest and recovery	R-HSA-167287	5.814167e-01	0.236
Pausing and recovery of HIV elongation	R-HSA-167290	5.814167e-01	0.236
Telomere Extension By Telomerase	R-HSA-171319	5.814167e-01	0.236
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.814167e-01	0.236
Formation of the Early Elongation Complex	R-HSA-113418	5.814167e-01	0.236
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.814167e-01	0.236
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.870775e-01	0.231
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.870775e-01	0.231
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.870775e-01	0.231
Cellular response to chemical stress	R-HSA-9711123	5.874527e-01	0.231
Insulin receptor signalling cascade	R-HSA-74751	5.930948e-01	0.227
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.930948e-01	0.227
Transmission across Chemical Synapses	R-HSA-112315	5.947359e-01	0.226
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.971234e-01	0.224
DNA methylation	R-HSA-5334118	5.971234e-01	0.224
Late endosomal microautophagy	R-HSA-9615710	5.971234e-01	0.224
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.971234e-01	0.224
Signaling by CSF3 (G-CSF)	R-HSA-9674555	5.971234e-01	0.224
Activation of Matrix Metalloproteinases	R-HSA-1592389	5.971234e-01	0.224
Regulation of gene expression in beta cells	R-HSA-210745	5.971234e-01	0.224
Platelet calcium homeostasis	R-HSA-418360	5.971234e-01	0.224
Signaling by Erythropoietin	R-HSA-9006335	5.971234e-01	0.224
Condensation of Prophase Chromosomes	R-HSA-2299718	5.996498e-01	0.222
mRNA Splicing - Minor Pathway	R-HSA-72165	5.996498e-01	0.222
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.996498e-01	0.222
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.996498e-01	0.222
Signaling downstream of RAS mutants	R-HSA-9649948	5.996498e-01	0.222
Signaling by RAS mutants	R-HSA-6802949	5.996498e-01	0.222
Regulation of pyruvate metabolism	R-HSA-9861718	5.996498e-01	0.222
IRAK1 recruits IKK complex	R-HSA-937039	6.012977e-01	0.221
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.012977e-01	0.221
GRB2 events in EGFR signaling	R-HSA-179812	6.012977e-01	0.221
RUNX3 regulates p14-ARF	R-HSA-8951936	6.012977e-01	0.221
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	6.012977e-01	0.221
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	6.012977e-01	0.221
Leading Strand Synthesis	R-HSA-69109	6.012977e-01	0.221
Polymerase switching	R-HSA-69091	6.012977e-01	0.221
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.012977e-01	0.221
Pervasive developmental disorders	R-HSA-9005895	6.012977e-01	0.221
Disorders of Nervous System Development	R-HSA-9697154	6.012977e-01	0.221
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.012977e-01	0.221
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	6.012977e-01	0.221
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.021701e-01	0.220
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.085775e-01	0.216
Neuronal System	R-HSA-112316	6.090994e-01	0.215
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	6.119680e-01	0.213
Meiosis	R-HSA-1500620	6.179981e-01	0.209
Signaling by ROBO receptors	R-HSA-376176	6.225095e-01	0.206
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	6.235771e-01	0.205
Chylomicron remodeling	R-HSA-8963901	6.235771e-01	0.205
Processing of SMDT1	R-HSA-8949664	6.235771e-01	0.205
Membrane binding and targetting of GAG proteins	R-HSA-174490	6.235771e-01	0.205
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	6.235771e-01	0.205
Frs2-mediated activation	R-HSA-170968	6.235771e-01	0.205
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	6.235771e-01	0.205
FGFR1c ligand binding and activation	R-HSA-190373	6.235771e-01	0.205
Interleukin-6 signaling	R-HSA-1059683	6.235771e-01	0.205
PI5P Regulates TP53 Acetylation	R-HSA-6811555	6.235771e-01	0.205
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	6.235771e-01	0.205
Kidney development	R-HSA-9830369	6.248670e-01	0.204
Trafficking of AMPA receptors	R-HSA-399719	6.271969e-01	0.203
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	6.271969e-01	0.203
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	6.271969e-01	0.203
PIP3 activates AKT signaling	R-HSA-1257604	6.350681e-01	0.197
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.351008e-01	0.197
Interleukin-1 family signaling	R-HSA-446652	6.412429e-01	0.193
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.415669e-01	0.193
Removal of the Flap Intermediate	R-HSA-69166	6.446127e-01	0.191
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.446127e-01	0.191
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	6.446127e-01	0.191
Retrograde neurotrophin signalling	R-HSA-177504	6.446127e-01	0.191
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	6.446127e-01	0.191
Physiological factors	R-HSA-5578768	6.446127e-01	0.191
Regulation of KIT signaling	R-HSA-1433559	6.446127e-01	0.191
HDL assembly	R-HSA-8963896	6.446127e-01	0.191
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.446127e-01	0.191
Signal regulatory protein family interactions	R-HSA-391160	6.446127e-01	0.191
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	6.451521e-01	0.190
Regulation of RAS by GAPs	R-HSA-5658442	6.473720e-01	0.189
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	6.550192e-01	0.184
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.550192e-01	0.184
Cyclin E associated events during G1/S transition	R-HSA-69202	6.550192e-01	0.184
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.554963e-01	0.183
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.554963e-01	0.183
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	6.554963e-01	0.183
Nuclear RNA decay	R-HSA-9930044	6.554963e-01	0.183
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.554963e-01	0.183
Recycling of bile acids and salts	R-HSA-159418	6.554963e-01	0.183
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	6.586507e-01	0.181
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.588574e-01	0.181
Generic Transcription Pathway	R-HSA-212436	6.609118e-01	0.180
Regulation of CDH1 Expression and Function	R-HSA-9764265	6.639432e-01	0.178
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	6.639432e-01	0.178
Spry regulation of FGF signaling	R-HSA-1295596	6.644740e-01	0.178
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.644740e-01	0.178
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.644740e-01	0.178
RNA Polymerase III Chain Elongation	R-HSA-73780	6.644740e-01	0.178
ERBB2 Regulates Cell Motility	R-HSA-6785631	6.644740e-01	0.178
Translesion synthesis by REV1	R-HSA-110312	6.644740e-01	0.178
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.644740e-01	0.178
Lysosphingolipid and LPA receptors	R-HSA-419408	6.644740e-01	0.178
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	6.644740e-01	0.178
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.644740e-01	0.178
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.644740e-01	0.178
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.644740e-01	0.178
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.647004e-01	0.177
Regulation of mitotic cell cycle	R-HSA-453276	6.647004e-01	0.177
Signaling by Hedgehog	R-HSA-5358351	6.657970e-01	0.177
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	6.689896e-01	0.175
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.689896e-01	0.175
Heme degradation	R-HSA-189483	6.689896e-01	0.175
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.696667e-01	0.174
RNA Polymerase I Promoter Escape	R-HSA-73772	6.696667e-01	0.174
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.696667e-01	0.174
Membrane Trafficking	R-HSA-199991	6.783459e-01	0.169
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	6.804200e-01	0.167
Amino acids regulate mTORC1	R-HSA-9639288	6.804200e-01	0.167
Smooth Muscle Contraction	R-HSA-445355	6.804200e-01	0.167
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.820520e-01	0.166
RAF activation	R-HSA-5673000	6.820520e-01	0.166
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.820520e-01	0.166
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.820520e-01	0.166
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.820520e-01	0.166
Translesion synthesis by POLI	R-HSA-5656121	6.832265e-01	0.165
Phosphorylation of the APC/C	R-HSA-176412	6.832265e-01	0.165
Killing mechanisms	R-HSA-9664420	6.832265e-01	0.165
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.832265e-01	0.165
Prolonged ERK activation events	R-HSA-169893	6.832265e-01	0.165
Induction of Cell-Cell Fusion	R-HSA-9733458	6.832265e-01	0.165
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.832265e-01	0.165
Negative regulation of FLT3	R-HSA-9706369	6.832265e-01	0.165
Virus Assembly and Release	R-HSA-168268	6.832265e-01	0.165
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.899398e-01	0.161
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	6.909111e-01	0.161
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.909111e-01	0.161
Signaling by NOTCH4	R-HSA-9013694	6.926194e-01	0.160
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.946895e-01	0.158
PERK regulates gene expression	R-HSA-381042	6.946895e-01	0.158
Oncogene Induced Senescence	R-HSA-2559585	6.946895e-01	0.158
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.964768e-01	0.157
Translesion synthesis by POLK	R-HSA-5655862	7.009320e-01	0.154
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	7.009320e-01	0.154
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	7.009320e-01	0.154
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	7.009320e-01	0.154
Scavenging by Class B Receptors	R-HSA-3000471	7.009320e-01	0.154
Transcriptional regulation of testis differentiation	R-HSA-9690406	7.009320e-01	0.154
Passive transport by Aquaporins	R-HSA-432047	7.009320e-01	0.154
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.009320e-01	0.154
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	7.009320e-01	0.154
tRNA modification in the mitochondrion	R-HSA-6787450	7.009320e-01	0.154
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	7.009320e-01	0.154
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.015489e-01	0.154
Protein ubiquitination	R-HSA-8852135	7.015489e-01	0.154
PRC2 methylates histones and DNA	R-HSA-212300	7.069087e-01	0.151
FLT3 signaling in disease	R-HSA-9682385	7.069087e-01	0.151
RUNX2 regulates bone development	R-HSA-8941326	7.069087e-01	0.151
GPVI-mediated activation cascade	R-HSA-114604	7.069087e-01	0.151
UCH proteinases	R-HSA-5689603	7.102899e-01	0.149
Ion homeostasis	R-HSA-5578775	7.111109e-01	0.148
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.111109e-01	0.148
Co-inhibition by PD-1	R-HSA-389948	7.121745e-01	0.147
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.123174e-01	0.147
Adherens junctions interactions	R-HSA-418990	7.130633e-01	0.147
PI3K events in ERBB2 signaling	R-HSA-1963642	7.176488e-01	0.144
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	7.176488e-01	0.144
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	7.176488e-01	0.144
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.176488e-01	0.144
Catecholamine biosynthesis	R-HSA-209905	7.176488e-01	0.144
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.176488e-01	0.144
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	7.187170e-01	0.143
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	7.187170e-01	0.143
Ovarian tumor domain proteases	R-HSA-5689896	7.187170e-01	0.143
PCP/CE pathway	R-HSA-4086400	7.272075e-01	0.138
Signaling by NOTCH	R-HSA-157118	7.289834e-01	0.137
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.301220e-01	0.137
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	7.301220e-01	0.137
Dual incision in TC-NER	R-HSA-6782135	7.302786e-01	0.137
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.302786e-01	0.137
ER to Golgi Anterograde Transport	R-HSA-199977	7.303848e-01	0.136
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.334322e-01	0.135
PKA activation	R-HSA-163615	7.334322e-01	0.135
PKA activation in glucagon signalling	R-HSA-164378	7.334322e-01	0.135
Chaperone Mediated Autophagy	R-HSA-9613829	7.334322e-01	0.135
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	7.334322e-01	0.135
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	7.334322e-01	0.135
FGFR1 ligand binding and activation	R-HSA-190242	7.334322e-01	0.135
GAB1 signalosome	R-HSA-180292	7.334322e-01	0.135
Vitamin D (calciferol) metabolism	R-HSA-196791	7.334322e-01	0.135
Sensory processing of sound	R-HSA-9659379	7.353854e-01	0.133
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.363503e-01	0.133
Cardiac conduction	R-HSA-5576891	7.390271e-01	0.131
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.411320e-01	0.130
Plasma lipoprotein clearance	R-HSA-8964043	7.411320e-01	0.130
MITF-M-dependent gene expression	R-HSA-9856651	7.480082e-01	0.126
Developmental Cell Lineages	R-HSA-9734767	7.480806e-01	0.126
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	7.483343e-01	0.126
PI-3K cascade:FGFR3	R-HSA-5654710	7.483343e-01	0.126
Pyrimidine biosynthesis	R-HSA-500753	7.483343e-01	0.126
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	7.483343e-01	0.126
STING mediated induction of host immune responses	R-HSA-1834941	7.483343e-01	0.126
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.483343e-01	0.126
O2/CO2 exchange in erythrocytes	R-HSA-1480926	7.483343e-01	0.126
Rap1 signalling	R-HSA-392517	7.483343e-01	0.126
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	7.483343e-01	0.126
HDL remodeling	R-HSA-8964058	7.483343e-01	0.126
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	7.483343e-01	0.126
Other interleukin signaling	R-HSA-449836	7.483343e-01	0.126
The NLRP3 inflammasome	R-HSA-844456	7.483343e-01	0.126
Diseases of hemostasis	R-HSA-9671793	7.483343e-01	0.126
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.517554e-01	0.124
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.517554e-01	0.124
HIV Transcription Elongation	R-HSA-167169	7.517554e-01	0.124
Glycogen metabolism	R-HSA-8982491	7.517554e-01	0.124
Ion channel transport	R-HSA-983712	7.547389e-01	0.122
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.571354e-01	0.121
MAP kinase activation	R-HSA-450294	7.571354e-01	0.121
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	7.588070e-01	0.120
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	7.620010e-01	0.118
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	7.620010e-01	0.118
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	7.620010e-01	0.118
VEGFR2 mediated vascular permeability	R-HSA-5218920	7.620010e-01	0.118
Maturation of spike protein	R-HSA-9694548	7.620010e-01	0.118
PI-3K cascade:FGFR4	R-HSA-5654720	7.624040e-01	0.118
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.624040e-01	0.118
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.624040e-01	0.118
Negative regulation of MET activity	R-HSA-6807004	7.624040e-01	0.118
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	7.624040e-01	0.118
Signal transduction by L1	R-HSA-445144	7.624040e-01	0.118
Protein hydroxylation	R-HSA-9629569	7.624040e-01	0.118
Intracellular signaling by second messengers	R-HSA-9006925	7.624753e-01	0.118
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.655942e-01	0.116
Signaling by PDGF	R-HSA-186797	7.655942e-01	0.116
Signaling by RAF1 mutants	R-HSA-9656223	7.718779e-01	0.112
MAP2K and MAPK activation	R-HSA-5674135	7.718779e-01	0.112
Negative regulation of MAPK pathway	R-HSA-5675221	7.718779e-01	0.112
Transcriptional regulation by RUNX2	R-HSA-8878166	7.746489e-01	0.111
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	7.756880e-01	0.110
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.756880e-01	0.110
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.756880e-01	0.110
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.756880e-01	0.110
ERK/MAPK targets	R-HSA-198753	7.756880e-01	0.110
Basigin interactions	R-HSA-210991	7.756880e-01	0.110
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	7.756880e-01	0.110
Cell-cell junction organization	R-HSA-421270	7.789019e-01	0.109
Oncogenic MAPK signaling	R-HSA-6802957	7.805904e-01	0.108
Incretin synthesis, secretion, and inactivation	R-HSA-400508	7.813953e-01	0.107
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	7.813953e-01	0.107
Ion transport by P-type ATPases	R-HSA-936837	7.817916e-01	0.107
CS-GAG biosynthesis	R-HSA-2022870	7.882301e-01	0.103
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.882301e-01	0.103
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.882301e-01	0.103
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.882301e-01	0.103
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	7.882301e-01	0.103
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.882301e-01	0.103
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.882301e-01	0.103
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	7.882301e-01	0.103
Assembly Of The HIV Virion	R-HSA-175474	7.882301e-01	0.103
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	7.895377e-01	0.103
Response of Mtb to phagocytosis	R-HSA-9637690	7.905624e-01	0.102
PTEN Regulation	R-HSA-6807070	7.909785e-01	0.102
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.977073e-01	0.098
Regulation of T cell activation by CD28 family	R-HSA-388841	7.993422e-01	0.097
PI-3K cascade:FGFR1	R-HSA-5654689	8.000716e-01	0.097
FGFR2 alternative splicing	R-HSA-6803529	8.000716e-01	0.097
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.000716e-01	0.097
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.000716e-01	0.097
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	8.000716e-01	0.097
LDL clearance	R-HSA-8964038	8.000716e-01	0.097
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.000716e-01	0.097
Pyruvate metabolism	R-HSA-70268	8.007844e-01	0.096
Signaling by TGFB family members	R-HSA-9006936	8.008559e-01	0.096
Nucleotide Excision Repair	R-HSA-5696398	8.009974e-01	0.096
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	8.009974e-01	0.096
SARS-CoV-1-host interactions	R-HSA-9692914	8.068224e-01	0.093
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.078835e-01	0.093
Interleukin-20 family signaling	R-HSA-8854691	8.112516e-01	0.091
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.112516e-01	0.091
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.112516e-01	0.091
Free fatty acids regulate insulin secretion	R-HSA-400451	8.112516e-01	0.091
Carnitine shuttle	R-HSA-200425	8.112516e-01	0.091
ABC transporters in lipid homeostasis	R-HSA-1369062	8.112516e-01	0.091
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	8.112516e-01	0.091
Growth hormone receptor signaling	R-HSA-982772	8.112516e-01	0.091
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.160564e-01	0.088
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.160564e-01	0.088
Diseases of DNA repair	R-HSA-9675135	8.160564e-01	0.088
Interleukin-6 family signaling	R-HSA-6783589	8.218071e-01	0.085
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.218071e-01	0.085
Mitochondrial RNA degradation	R-HSA-9836573	8.218071e-01	0.085
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.218071e-01	0.085
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	8.239168e-01	0.084
Degradation of beta-catenin by the destruction complex	R-HSA-195253	8.249044e-01	0.084
Interleukin-17 signaling	R-HSA-448424	8.249044e-01	0.084
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.287767e-01	0.082
MyD88-independent TLR4 cascade	R-HSA-166166	8.287767e-01	0.082
Developmental Biology	R-HSA-1266738	8.308612e-01	0.080
NoRC negatively regulates rRNA expression	R-HSA-427413	8.313350e-01	0.080
Co-stimulation by CD28	R-HSA-389356	8.314740e-01	0.080
Plasma lipoprotein remodeling	R-HSA-8963899	8.314740e-01	0.080
PI-3K cascade:FGFR2	R-HSA-5654695	8.317729e-01	0.080
Activation of G protein gated Potassium channels	R-HSA-1296041	8.317729e-01	0.080
G protein gated Potassium channels	R-HSA-1296059	8.317729e-01	0.080
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.317729e-01	0.080
Long-term potentiation	R-HSA-9620244	8.317729e-01	0.080
Tight junction interactions	R-HSA-420029	8.317729e-01	0.080
Acyl chain remodelling of PS	R-HSA-1482801	8.317729e-01	0.080
Signaling by Insulin receptor	R-HSA-74752	8.366466e-01	0.077
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.383067e-01	0.077
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.387373e-01	0.076
Disorders of transmembrane transporters	R-HSA-5619115	8.387927e-01	0.076
MET activates PTK2 signaling	R-HSA-8874081	8.411819e-01	0.075
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.411819e-01	0.075
Myogenesis	R-HSA-525793	8.411819e-01	0.075
Urea cycle	R-HSA-70635	8.411819e-01	0.075
Sphingolipid catabolism	R-HSA-9845614	8.411819e-01	0.075
Suppression of phagosomal maturation	R-HSA-9637687	8.411819e-01	0.075
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.411819e-01	0.075
Signaling by FGFR2 in disease	R-HSA-5655253	8.457160e-01	0.073
Potential therapeutics for SARS	R-HSA-9679191	8.476080e-01	0.072
Cristae formation	R-HSA-8949613	8.500652e-01	0.071
RNA Polymerase I Promoter Opening	R-HSA-73728	8.500652e-01	0.071
EPHA-mediated growth cone collapse	R-HSA-3928663	8.500652e-01	0.071
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.500652e-01	0.071
Meiotic recombination	R-HSA-912446	8.524192e-01	0.069
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	8.559976e-01	0.068
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.584521e-01	0.066
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.584521e-01	0.066
Pyrimidine salvage	R-HSA-73614	8.584521e-01	0.066
Pyroptosis	R-HSA-5620971	8.584521e-01	0.066
Inflammasomes	R-HSA-622312	8.584521e-01	0.066
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	8.588559e-01	0.066
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	8.588559e-01	0.066
MITF-M-regulated melanocyte development	R-HSA-9730414	8.599541e-01	0.066
Ub-specific processing proteases	R-HSA-5689880	8.602122e-01	0.065
Potassium Channels	R-HSA-1296071	8.622552e-01	0.064
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.650348e-01	0.063
Regulation of PTEN stability and activity	R-HSA-8948751	8.650348e-01	0.063
Nucleotide biosynthesis	R-HSA-8956320	8.650348e-01	0.063
mRNA Capping	R-HSA-72086	8.663703e-01	0.062
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.663703e-01	0.062
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.663703e-01	0.062
DARPP-32 events	R-HSA-180024	8.663703e-01	0.062
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.663703e-01	0.062
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.669437e-01	0.062
SARS-CoV-1 Infection	R-HSA-9678108	8.673941e-01	0.062
Nuclear Receptor transcription pathway	R-HSA-383280	8.708953e-01	0.060
Interleukin-10 signaling	R-HSA-6783783	8.708953e-01	0.060
Translation initiation complex formation	R-HSA-72649	8.709646e-01	0.060
MyD88 cascade initiated on plasma membrane	R-HSA-975871	8.714946e-01	0.060
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	8.714946e-01	0.060
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	8.714946e-01	0.060
Integration of energy metabolism	R-HSA-163685	8.720669e-01	0.059
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.766539e-01	0.057
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.788380e-01	0.056
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.788380e-01	0.056
Hemostasis	R-HSA-109582	8.805635e-01	0.055
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.805821e-01	0.055
Budding and maturation of HIV virion	R-HSA-162588	8.809041e-01	0.055
EGFR downregulation	R-HSA-182971	8.809041e-01	0.055
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.821110e-01	0.054
Ribosomal scanning and start codon recognition	R-HSA-72702	8.821110e-01	0.054
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.821110e-01	0.054
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.838917e-01	0.054
Extra-nuclear estrogen signaling	R-HSA-9009391	8.843504e-01	0.053
Amyloid fiber formation	R-HSA-977225	8.851788e-01	0.053
IRS-mediated signalling	R-HSA-112399	8.873441e-01	0.052
Synthesis of PA	R-HSA-1483166	8.873441e-01	0.052
Inwardly rectifying K+ channels	R-HSA-1296065	8.875675e-01	0.052
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	8.875675e-01	0.052
PI Metabolism	R-HSA-1483255	8.883796e-01	0.051
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.901126e-01	0.051
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.901126e-01	0.051
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.923611e-01	0.049
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.938586e-01	0.049
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.938586e-01	0.049
Regulation of necroptotic cell death	R-HSA-5675482	8.938586e-01	0.049
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.960715e-01	0.048
Peroxisomal protein import	R-HSA-9033241	8.971699e-01	0.047
Clathrin-mediated endocytosis	R-HSA-8856828	8.997309e-01	0.046
CS/DS degradation	R-HSA-2024101	8.997980e-01	0.046
Glucagon signaling in metabolic regulation	R-HSA-163359	8.997980e-01	0.046
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.997980e-01	0.046
Effects of PIP2 hydrolysis	R-HSA-114508	8.997980e-01	0.046
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.997980e-01	0.046
Miscellaneous transport and binding events	R-HSA-5223345	8.997980e-01	0.046
RAB geranylgeranylation	R-HSA-8873719	9.017779e-01	0.045
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.054054e-01	0.043
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.054054e-01	0.043
Calnexin/calreticulin cycle	R-HSA-901042	9.054054e-01	0.043
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.054054e-01	0.043
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.054054e-01	0.043
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.058709e-01	0.043
Collagen degradation	R-HSA-1442490	9.061927e-01	0.043
IRS-related events triggered by IGF1R	R-HSA-2428928	9.061927e-01	0.043
Aquaporin-mediated transport	R-HSA-445717	9.061927e-01	0.043
Endogenous sterols	R-HSA-211976	9.061927e-01	0.043
Nucleotide salvage	R-HSA-8956321	9.061927e-01	0.043
Formation of paraxial mesoderm	R-HSA-9793380	9.061927e-01	0.043
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.070487e-01	0.042
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.095809e-01	0.041
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.095809e-01	0.041
Platelet degranulation	R-HSA-114608	9.099740e-01	0.041
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.100681e-01	0.041
NCAM signaling for neurite out-growth	R-HSA-375165	9.104213e-01	0.041
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.106993e-01	0.041
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	9.106993e-01	0.041
Platelet activation, signaling and aggregation	R-HSA-76002	9.132702e-01	0.039
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.132947e-01	0.039
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.144708e-01	0.039
Toll-like Receptor Cascades	R-HSA-168898	9.146179e-01	0.039
HSF1 activation	R-HSA-3371511	9.156972e-01	0.038
Calmodulin induced events	R-HSA-111933	9.156972e-01	0.038
CaM pathway	R-HSA-111997	9.156972e-01	0.038
Regulation of TP53 Degradation	R-HSA-6804757	9.156972e-01	0.038
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.164176e-01	0.038
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.165523e-01	0.038
Diseases of programmed cell death	R-HSA-9645723	9.166056e-01	0.038
Gastrulation	R-HSA-9758941	9.169607e-01	0.038
Voltage gated Potassium channels	R-HSA-1296072	9.204157e-01	0.036
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.204157e-01	0.036
Degradation of DVL	R-HSA-4641258	9.204157e-01	0.036
SLC-mediated transport of organic cations	R-HSA-549127	9.204157e-01	0.036
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.204157e-01	0.036
Reproduction	R-HSA-1474165	9.214012e-01	0.036
Neurotransmitter release cycle	R-HSA-112310	9.231294e-01	0.035
Purine salvage	R-HSA-74217	9.248704e-01	0.034
RIPK1-mediated regulated necrosis	R-HSA-5213460	9.248704e-01	0.034
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.248704e-01	0.034
SLC-mediated transport of inorganic anions	R-HSA-9958790	9.248704e-01	0.034
FCERI mediated MAPK activation	R-HSA-2871796	9.251919e-01	0.034
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.260746e-01	0.033
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.279272e-01	0.032
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.290105e-01	0.032
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.290760e-01	0.032
Transcriptional Regulation by E2F6	R-HSA-8953750	9.290760e-01	0.032
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.290760e-01	0.032
Stabilization of p53	R-HSA-69541	9.290760e-01	0.032
Regulation of TP53 Expression and Degradation	R-HSA-6806003	9.290760e-01	0.032
Eukaryotic Translation Elongation	R-HSA-156842	9.320427e-01	0.031
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.320427e-01	0.031
Regulated Necrosis	R-HSA-5218859	9.322624e-01	0.030
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.330464e-01	0.030
Diseases of Immune System	R-HSA-5260271	9.330464e-01	0.030
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.330464e-01	0.030
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.330464e-01	0.030
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.330464e-01	0.030
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	9.356000e-01	0.029
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.367947e-01	0.028
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.367947e-01	0.028
Cellular response to starvation	R-HSA-9711097	9.379601e-01	0.028
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.379881e-01	0.028
Transport to the Golgi and subsequent modification	R-HSA-948021	9.380207e-01	0.028
Beta-catenin independent WNT signaling	R-HSA-3858494	9.383391e-01	0.028
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.383477e-01	0.028
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.383477e-01	0.028
Cap-dependent Translation Initiation	R-HSA-72737	9.402955e-01	0.027
Eukaryotic Translation Initiation	R-HSA-72613	9.402955e-01	0.027
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.403335e-01	0.027
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.403335e-01	0.027
Translation of Structural Proteins	R-HSA-9683701	9.403335e-01	0.027
Retinoid metabolism and transport	R-HSA-975634	9.411923e-01	0.026
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	9.411923e-01	0.026
Metabolism of porphyrins	R-HSA-189445	9.411923e-01	0.026
Rab regulation of trafficking	R-HSA-9007101	9.425245e-01	0.026
Peptide hormone metabolism	R-HSA-2980736	9.425245e-01	0.026
Activation of GABAB receptors	R-HSA-991365	9.436743e-01	0.025
GABA B receptor activation	R-HSA-977444	9.436743e-01	0.025
Ca-dependent events	R-HSA-111996	9.436743e-01	0.025
Parasite infection	R-HSA-9664407	9.464743e-01	0.024
Leishmania phagocytosis	R-HSA-9664417	9.464743e-01	0.024
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.464743e-01	0.024
Ca2+ pathway	R-HSA-4086398	9.465114e-01	0.024
Defective pyroptosis	R-HSA-9710421	9.468282e-01	0.024
Transcriptional regulation by RUNX3	R-HSA-8878159	9.470793e-01	0.024
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.483504e-01	0.023
Regulation of insulin secretion	R-HSA-422356	9.492622e-01	0.023
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.498057e-01	0.022
Synthesis of bile acids and bile salts	R-HSA-192105	9.513611e-01	0.022
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.526167e-01	0.021
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.526167e-01	0.021
Fanconi Anemia Pathway	R-HSA-6783310	9.526167e-01	0.021
DAG and IP3 signaling	R-HSA-1489509	9.526167e-01	0.021
Degradation of cysteine and homocysteine	R-HSA-1614558	9.526167e-01	0.021
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.541793e-01	0.020
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.552704e-01	0.020
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.552704e-01	0.020
Vesicle-mediated transport	R-HSA-5653656	9.553405e-01	0.020
Translation of Structural Proteins	R-HSA-9694635	9.558059e-01	0.020
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.577756e-01	0.019
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.577756e-01	0.019
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.577756e-01	0.019
Cholesterol biosynthesis	R-HSA-191273	9.578759e-01	0.019
Adaptive Immune System	R-HSA-1280218	9.582718e-01	0.019
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.598528e-01	0.018
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.606921e-01	0.017
Response of endothelial cells to shear stress	R-HSA-9860931	9.606921e-01	0.017
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.617406e-01	0.017
Degradation of CDH1	R-HSA-9766229	9.623734e-01	0.017
p53-Dependent G1 DNA Damage Response	R-HSA-69563	9.623734e-01	0.017
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	9.623734e-01	0.017
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.635431e-01	0.016
PI3K Cascade	R-HSA-109704	9.644812e-01	0.016
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.644812e-01	0.016
Cytosolic sulfonation of small molecules	R-HSA-156584	9.664710e-01	0.015
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.669063e-01	0.015
Protein localization	R-HSA-9609507	9.678582e-01	0.014
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.683217e-01	0.014
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.683217e-01	0.014
Uptake and actions of bacterial toxins	R-HSA-5339562	9.683494e-01	0.014
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	9.684739e-01	0.014
Bile acid and bile salt metabolism	R-HSA-194068	9.709630e-01	0.013
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.713974e-01	0.013
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.717969e-01	0.012
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.733772e-01	0.012
Paracetamol ADME	R-HSA-9753281	9.733772e-01	0.012
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.733949e-01	0.012
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.733949e-01	0.012
Metabolism of amine-derived hormones	R-HSA-209776	9.748691e-01	0.011
Peptide chain elongation	R-HSA-156902	9.752977e-01	0.011
Cellular responses to mechanical stimuli	R-HSA-9855142	9.756328e-01	0.011
Regulation of CDH1 Function	R-HSA-9764561	9.762775e-01	0.010
ER-Phagosome pathway	R-HSA-1236974	9.764796e-01	0.010
rRNA processing	R-HSA-72312	9.765277e-01	0.010
Class B/2 (Secretin family receptors)	R-HSA-373080	9.776067e-01	0.010
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.786815e-01	0.009
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.788622e-01	0.009
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.797062e-01	0.009
GABA receptor activation	R-HSA-977443	9.800470e-01	0.009
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.800470e-01	0.009
PLC beta mediated events	R-HSA-112043	9.811655e-01	0.008
Mitochondrial protein import	R-HSA-1268020	9.822213e-01	0.008
Collagen formation	R-HSA-1474290	9.825020e-01	0.008
G1/S DNA Damage Checkpoints	R-HSA-69615	9.832180e-01	0.007
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.833480e-01	0.007
Formation of a pool of free 40S subunits	R-HSA-72689	9.841541e-01	0.007
Eukaryotic Translation Termination	R-HSA-72764	9.841541e-01	0.007
G alpha (s) signalling events	R-HSA-418555	9.844328e-01	0.007
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.849223e-01	0.007
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.849223e-01	0.007
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.858856e-01	0.006
G-protein mediated events	R-HSA-112040	9.866771e-01	0.006
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.873106e-01	0.006
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.874242e-01	0.005
ABC-family proteins mediated transport	R-HSA-382556	9.876486e-01	0.005
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.878271e-01	0.005
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.880506e-01	0.005
Interleukin-1 signaling	R-HSA-9020702	9.882513e-01	0.005
Selenocysteine synthesis	R-HSA-2408557	9.882513e-01	0.005
COPII-mediated vesicle transport	R-HSA-204005	9.887953e-01	0.005
Oxidative Stress Induced Senescence	R-HSA-2559580	9.888252e-01	0.005
Viral mRNA Translation	R-HSA-192823	9.893718e-01	0.005
Hedgehog 'on' state	R-HSA-5632684	9.894237e-01	0.005
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.894237e-01	0.005
Purine catabolism	R-HSA-74259	9.900170e-01	0.004
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.900170e-01	0.004
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.900170e-01	0.004
ROS and RNS production in phagocytes	R-HSA-1222556	9.911056e-01	0.004
Interferon gamma signaling	R-HSA-877300	9.911221e-01	0.004
Platelet homeostasis	R-HSA-418346	9.913089e-01	0.004
Citric acid cycle (TCA cycle)	R-HSA-71403	9.916046e-01	0.004
Iron uptake and transport	R-HSA-917937	9.916046e-01	0.004
Antigen processing-Cross presentation	R-HSA-1236975	9.921435e-01	0.003
Drug ADME	R-HSA-9748784	9.933965e-01	0.003
C-type lectin receptors (CLRs)	R-HSA-5621481	9.949383e-01	0.002
Peroxisomal lipid metabolism	R-HSA-390918	9.950078e-01	0.002
Role of phospholipids in phagocytosis	R-HSA-2029485	9.950255e-01	0.002
Interferon alpha/beta signaling	R-HSA-909733	9.950255e-01	0.002
Infectious disease	R-HSA-5663205	9.957302e-01	0.002
Sulfur amino acid metabolism	R-HSA-1614635	9.958023e-01	0.002
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.963404e-01	0.002
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.967557e-01	0.001
Metabolism of nucleotides	R-HSA-15869	9.967564e-01	0.001
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.973564e-01	0.001
Mitochondrial protein degradation	R-HSA-9837999	9.975049e-01	0.001
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.975606e-01	0.001
Metabolism of steroids	R-HSA-8957322	9.977609e-01	0.001
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.977774e-01	0.001
Mitochondrial translation elongation	R-HSA-5389840	9.979022e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.981287e-01	0.001
Mitochondrial translation initiation	R-HSA-5368286	9.981314e-01	0.001
Parasitic Infection Pathways	R-HSA-9824443	9.984234e-01	0.001
Leishmania infection	R-HSA-9658195	9.984234e-01	0.001
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.986007e-01	0.001
Opioid Signalling	R-HSA-111885	9.986793e-01	0.001
Ribosome-associated quality control	R-HSA-9948299	9.986997e-01	0.001
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.987536e-01	0.001
Immune System	R-HSA-168256	9.987700e-01	0.001
Cell surface interactions at the vascular wall	R-HSA-202733	9.990408e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.990667e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.991002e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.991212e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.991687e-01	0.000
Visual phototransduction	R-HSA-2187338	9.992294e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.993395e-01	0.000
Initial triggering of complement	R-HSA-166663	9.993406e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.993406e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.993675e-01	0.000
Neddylation	R-HSA-8951664	9.994966e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.996132e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.996513e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.996709e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.996858e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.997069e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.997320e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.997418e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.997537e-01	0.000
Post-translational protein modification	R-HSA-597592	9.997710e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.997930e-01	0.000
Respiratory electron transport	R-HSA-611105	9.998586e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.998698e-01	0.000
Neutrophil degranulation	R-HSA-6798695	9.998973e-01	0.000
Complement cascade	R-HSA-166658	9.999182e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999349e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999388e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999455e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999589e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999592e-01	0.000
Disease	R-HSA-1643685	9.999644e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999645e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999848e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999848e-01	0.000
Translation	R-HSA-72766	9.999900e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999919e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999947e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999953e-01	0.000
Keratinization	R-HSA-6805567	9.999979e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999993e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999995e-01	0.000
Fatty acid metabolism	R-HSA-8978868	9.999997e-01	0.000
Transport of small molecules	R-HSA-382551	9.999998e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999998e-01	0.000
Biological oxidations	R-HSA-211859	9.999999e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999999e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999999e-01	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle, Mitotic	R-HSA-69278	4.756195e-13	12.323
M Phase	R-HSA-68886	2.711609e-12	11.567
Cell Cycle	R-HSA-1640170	3.423040e-12	11.466
Mitotic Prometaphase	R-HSA-68877	2.093080e-10	9.679
Mitotic Anaphase	R-HSA-68882	4.231365e-09	8.374
Mitotic Metaphase and Anaphase	R-HSA-2555396	4.922522e-09	8.308
Recycling pathway of L1	R-HSA-437239	8.545280e-09	8.068
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.282597e-08	7.642
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	9.159599e-08	7.038
Separation of Sister Chromatids	R-HSA-2467813	1.028191e-07	6.988
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.602265e-07	6.795
Aggrephagy	R-HSA-9646399	1.689595e-07	6.772
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.345247e-07	6.476
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.922943e-07	6.406
L1CAM interactions	R-HSA-373760	5.019638e-07	6.299
Transport of connexons to the plasma membrane	R-HSA-190872	5.626271e-07	6.250
Axon guidance	R-HSA-422475	6.005482e-07	6.221
Signal Transduction	R-HSA-162582	8.566780e-07	6.067
Nervous system development	R-HSA-9675108	2.001023e-06	5.699
Nuclear Envelope Breakdown	R-HSA-2980766	2.323446e-06	5.634
Gap junction trafficking	R-HSA-190828	3.102081e-06	5.508
Gap junction trafficking and regulation	R-HSA-157858	3.422691e-06	5.466
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.810507e-06	5.008
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.076206e-05	4.968
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.225034e-05	4.912
Mitotic G2-G2/M phases	R-HSA-453274	1.559528e-05	4.807
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.799022e-05	4.745
Selective autophagy	R-HSA-9663891	2.394541e-05	4.621
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.591281e-05	4.445
Mitotic Prophase	R-HSA-68875	3.573914e-05	4.447
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.380783e-05	4.358
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	5.054912e-05	4.296
G2/M Transition	R-HSA-69275	5.184000e-05	4.285
Apoptotic execution phase	R-HSA-75153	5.903932e-05	4.229
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	5.809426e-05	4.236
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	6.918974e-05	4.160
Cell-extracellular matrix interactions	R-HSA-446353	7.474345e-05	4.126
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	8.054905e-05	4.094
Loss of Nlp from mitotic centrosomes	R-HSA-380259	8.054905e-05	4.094
Oncogenic MAPK signaling	R-HSA-6802957	8.054018e-05	4.094
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	9.186272e-05	4.037
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.169961e-04	3.932
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.173495e-04	3.931
AURKA Activation by TPX2	R-HSA-8854518	1.408078e-04	3.851
PKMTs methylate histone lysines	R-HSA-3214841	1.479389e-04	3.830
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.712144e-04	3.766
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.790106e-04	3.747
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.836489e-04	3.736
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.854511e-04	3.732
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.936479e-04	3.713
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.057923e-04	3.687
Mitotic Spindle Checkpoint	R-HSA-69618	2.111781e-04	3.675
Cellular responses to stimuli	R-HSA-8953897	2.227068e-04	3.652
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.305719e-04	3.637
Formation of annular gap junctions	R-HSA-196025	2.880366e-04	3.541
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.835907e-04	3.547
Nuclear import of Rev protein	R-HSA-180746	2.944179e-04	3.531
Gap junction assembly	R-HSA-190861	2.944179e-04	3.531
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.947679e-04	3.531
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	3.661273e-04	3.436
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	3.661273e-04	3.436
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	3.661273e-04	3.436
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.676723e-04	3.435
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	3.728514e-04	3.428
Cell-Cell communication	R-HSA-1500931	3.869062e-04	3.412
Cellular responses to stress	R-HSA-2262752	4.020999e-04	3.396
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.559004e-04	3.341
Gap junction degradation	R-HSA-190873	4.813487e-04	3.318
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.438408e-04	3.265
Amplification of signal from the kinetochores	R-HSA-141424	5.510141e-04	3.259
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	5.510141e-04	3.259
Semaphorin interactions	R-HSA-373755	5.735453e-04	3.241
IPs transport between nucleus and cytosol	R-HSA-1855170	5.935497e-04	3.227
Centrosome maturation	R-HSA-380287	6.190974e-04	3.208
COPI-mediated anterograde transport	R-HSA-6807878	6.253166e-04	3.204
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	7.263083e-04	3.139
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	7.460284e-04	3.127
snRNP Assembly	R-HSA-191859	7.549742e-04	3.122
Metabolism of non-coding RNA	R-HSA-194441	7.549742e-04	3.122
Chromatin modifying enzymes	R-HSA-3247509	7.714554e-04	3.113
Chromatin organization	R-HSA-4839726	8.383940e-04	3.077
Autophagy	R-HSA-9612973	8.814609e-04	3.055
NS1 Mediated Effects on Host Pathways	R-HSA-168276	8.896208e-04	3.051
Cellular response to heat stress	R-HSA-3371556	8.918614e-04	3.050
Cell junction organization	R-HSA-446728	8.918632e-04	3.050
Signaling by Hippo	R-HSA-2028269	1.008281e-03	2.996
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.138186e-03	2.944
Interactions of Rev with host cellular proteins	R-HSA-177243	1.086893e-03	2.964
PKR-mediated signaling	R-HSA-9833482	1.263841e-03	2.898
Macroautophagy	R-HSA-1632852	1.282151e-03	2.892
Signaling downstream of RAS mutants	R-HSA-9649948	1.451815e-03	2.838
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.451815e-03	2.838
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.451815e-03	2.838
Signaling by RAS mutants	R-HSA-6802949	1.451815e-03	2.838
Cellular Senescence	R-HSA-2559583	1.366747e-03	2.864
mTORC1-mediated signalling	R-HSA-166208	1.484060e-03	2.829
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.579964e-03	2.801
Signaling by RAF1 mutants	R-HSA-9656223	1.592611e-03	2.798
Post NMDA receptor activation events	R-HSA-438064	1.618565e-03	2.791
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.685021e-03	2.773
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.724524e-03	2.763
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.724963e-03	2.763
Cilium Assembly	R-HSA-5617833	1.777949e-03	2.750
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.089758e-03	2.680
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.163065e-03	2.665
Regulation of PTEN gene transcription	R-HSA-8943724	2.190169e-03	2.660
IkBA variant leads to EDA-ID	R-HSA-5603029	2.272372e-03	2.644
Transcriptional Regulation by E2F6	R-HSA-8953750	2.516366e-03	2.599
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.519329e-03	2.599
HCMV Early Events	R-HSA-9609690	2.858191e-03	2.544
tRNA processing in the nucleus	R-HSA-6784531	2.926321e-03	2.534
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.427614e-03	2.465
Metabolism of RNA	R-HSA-8953854	3.256066e-03	2.487
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.361645e-03	2.473
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.583913e-03	2.446
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.739967e-03	2.427
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.811719e-03	2.419
mRNA Splicing - Major Pathway	R-HSA-72163	4.176064e-03	2.379
MAP2K and MAPK activation	R-HSA-5674135	4.241136e-03	2.373
Diseases of mitotic cell cycle	R-HSA-9675126	4.365397e-03	2.360
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	4.394986e-03	2.357
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.949556e-03	2.305
FOXO-mediated transcription of cell death genes	R-HSA-9614657	4.962694e-03	2.304
Membrane Trafficking	R-HSA-199991	4.868866e-03	2.313
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.962694e-03	2.304
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.962694e-03	2.304
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.264974e-03	2.279
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	5.364038e-03	2.271
HIV Life Cycle	R-HSA-162587	5.741180e-03	2.241
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	5.922349e-03	2.228
HIV Infection	R-HSA-162906	6.046849e-03	2.218
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	6.452053e-03	2.190
EPH-Ephrin signaling	R-HSA-2682334	6.684942e-03	2.175
Cell Cycle Checkpoints	R-HSA-69620	6.755854e-03	2.170
NRAGE signals death through JNK	R-HSA-193648	6.784650e-03	2.168
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	7.475274e-03	2.126
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.163494e-03	2.145
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.163494e-03	2.145
Organelle biogenesis and maintenance	R-HSA-1852241	7.765839e-03	2.110
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.903051e-03	2.102
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	7.989079e-03	2.098
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.989079e-03	2.098
Regulation of CDH1 Gene Transcription	R-HSA-9764560	8.199698e-03	2.086
Host Interactions of HIV factors	R-HSA-162909	8.360415e-03	2.078
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	8.405956e-03	2.075
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	8.405956e-03	2.075
Hedgehog 'off' state	R-HSA-5610787	8.473030e-03	2.072
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	8.516198e-03	2.070
Adherens junctions interactions	R-HSA-418990	8.650184e-03	2.063
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.810156e-03	2.055
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.863156e-03	2.052
mRNA Splicing	R-HSA-72172	8.971091e-03	2.047
Sema4D in semaphorin signaling	R-HSA-400685	9.229349e-03	2.035
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.205784e-03	2.036
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.000118e-02	2.000
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.125494e-03	2.040
Kinesins	R-HSA-983189	1.128778e-02	1.947
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.151244e-02	1.939
Translation initiation complex formation	R-HSA-72649	1.169696e-02	1.932
G0 and Early G1	R-HSA-1538133	1.185055e-02	1.926
WNT mediated activation of DVL	R-HSA-201688	1.202803e-02	1.920
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.202803e-02	1.920
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.215825e-02	1.915
MTOR signalling	R-HSA-165159	1.218482e-02	1.914
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.222581e-02	1.913
Viral Messenger RNA Synthesis	R-HSA-168325	1.271585e-02	1.896
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.285222e-02	1.891
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.315077e-02	1.881
ER to Golgi Anterograde Transport	R-HSA-199977	1.338714e-02	1.873
MHC class II antigen presentation	R-HSA-2132295	1.365952e-02	1.865
Ribosomal scanning and start codon recognition	R-HSA-72702	1.495655e-02	1.825
HCMV Infection	R-HSA-9609646	1.541396e-02	1.812
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.394696e-02	1.856
Transcriptional regulation by RUNX1	R-HSA-8878171	1.408666e-02	1.851
Heme signaling	R-HSA-9707616	1.428084e-02	1.845
p75 NTR receptor-mediated signalling	R-HSA-193704	1.444980e-02	1.840
Inositol phosphate metabolism	R-HSA-1483249	1.473938e-02	1.832
Late Phase of HIV Life Cycle	R-HSA-162599	1.563170e-02	1.806
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.618674e-02	1.791
Ephrin signaling	R-HSA-3928664	1.618674e-02	1.791
Polo-like kinase mediated events	R-HSA-156711	1.618674e-02	1.791
Chaperone Mediated Autophagy	R-HSA-9613829	1.618674e-02	1.791
Clathrin-mediated endocytosis	R-HSA-8856828	1.679208e-02	1.775
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.923010e-02	1.716
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.923010e-02	1.716
CREB phosphorylation	R-HSA-199920	1.932514e-02	1.714
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.791688e-02	1.747
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.874491e-02	1.727
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.887234e-02	1.724
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.875023e-02	1.727
Circadian clock	R-HSA-9909396	1.845848e-02	1.734
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	1.932514e-02	1.714
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.732871e-02	1.761
Signaling by ALK in cancer	R-HSA-9700206	1.732871e-02	1.761
Developmental Biology	R-HSA-1266738	1.811918e-02	1.742
Platelet degranulation	R-HSA-114608	2.006330e-02	1.698
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.028147e-02	1.693
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.138094e-02	1.670
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.155108e-02	1.667
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.155108e-02	1.667
Diseases of Telomere Maintenance	R-HSA-9673013	2.155108e-02	1.667
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.155108e-02	1.667
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.155108e-02	1.667
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.155108e-02	1.667
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.155108e-02	1.667
Death Receptor Signaling	R-HSA-73887	2.172641e-02	1.663
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.190302e-02	1.659
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.195393e-02	1.658
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.198321e-02	1.658
Smooth Muscle Contraction	R-HSA-445355	2.229650e-02	1.652
Apoptosis	R-HSA-109581	2.271322e-02	1.644
Formation of definitive endoderm	R-HSA-9823730	2.408725e-02	1.618
Cell-cell junction organization	R-HSA-421270	2.423631e-02	1.616
MECP2 regulates transcription factors	R-HSA-9022707	2.703226e-02	1.568
Activation of PUMA and translocation to mitochondria	R-HSA-139915	2.703226e-02	1.568
Cohesin Loading onto Chromatin	R-HSA-2470946	2.703226e-02	1.568
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.809054e-02	1.551
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.655739e-02	1.576
Phosphorylation of the APC/C	R-HSA-176412	2.655739e-02	1.576
HATs acetylate histones	R-HSA-3214847	2.604376e-02	1.584
Activation of RAC1	R-HSA-428540	2.809054e-02	1.551
Ovarian tumor domain proteases	R-HSA-5689896	2.877311e-02	1.541
Intraflagellar transport	R-HSA-5620924	2.637285e-02	1.579
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.655739e-02	1.576
Chaperonin-mediated protein folding	R-HSA-390466	2.587976e-02	1.587
ISG15 antiviral mechanism	R-HSA-1169408	2.760819e-02	1.559
SARS-CoV-1-host interactions	R-HSA-9692914	2.805659e-02	1.552
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.968021e-02	1.528
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	3.064363e-02	1.514
Processing of Intronless Pre-mRNAs	R-HSA-77595	3.249705e-02	1.488
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.270426e-02	1.485
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	3.271452e-02	1.485
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.334479e-02	1.477
Regulation of MECP2 expression and activity	R-HSA-9022692	3.391396e-02	1.470
Regulation of CDH1 Function	R-HSA-9764561	3.438551e-02	1.464
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.550173e-02	1.450
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.568760e-02	1.447
MITF-M-regulated melanocyte development	R-HSA-9730414	3.597485e-02	1.444
G alpha (12/13) signalling events	R-HSA-416482	3.616496e-02	1.442
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.616496e-02	1.442
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.672164e-02	1.435
S Phase	R-HSA-69242	3.771267e-02	1.424
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.836265e-02	1.416
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	3.880064e-02	1.411
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.895517e-02	1.409
Transcriptional regulation by small RNAs	R-HSA-5578749	3.923754e-02	1.406
Specification of primordial germ cells	R-HSA-9827857	3.923775e-02	1.406
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	4.509061e-02	1.346
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	4.509061e-02	1.346
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	4.509061e-02	1.346
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	4.509061e-02	1.346
IKBKB deficiency causes SCID	R-HSA-5602636	4.509061e-02	1.346
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	4.489724e-02	1.348
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.726986e-02	1.325
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.726986e-02	1.325
ALK mutants bind TKIs	R-HSA-9700645	4.726986e-02	1.325
Formation of axial mesoderm	R-HSA-9796292	4.401301e-02	1.356
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.401301e-02	1.356
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.401301e-02	1.356
Late endosomal microautophagy	R-HSA-9615710	4.589669e-02	1.338
mRNA 3'-end processing	R-HSA-72187	4.089194e-02	1.388
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.174735e-02	1.379
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.174735e-02	1.379
Adipogenesis	R-HSA-9843745	4.612361e-02	1.336
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.665656e-02	1.331
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.489724e-02	1.348
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.255160e-02	1.371
Breakdown of the nuclear lamina	R-HSA-352238	4.509061e-02	1.346
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.401268e-02	1.356
Protein folding	R-HSA-391251	4.228649e-02	1.374
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	4.385039e-02	1.358
Influenza Infection	R-HSA-168255	4.218770e-02	1.375
Cytokine Signaling in Immune system	R-HSA-1280215	4.732554e-02	1.325
Signaling by VEGF	R-HSA-194138	4.732774e-02	1.325
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.992709e-02	1.302
PTEN Regulation	R-HSA-6807070	5.062412e-02	1.296
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.071358e-02	1.295
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.229048e-02	1.282
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	5.440630e-02	1.264
Neurodegenerative Diseases	R-HSA-8863678	5.440630e-02	1.264
G1/S-Specific Transcription	R-HSA-69205	5.594834e-02	1.252
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	5.982545e-02	1.223
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.982545e-02	1.223
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	5.982545e-02	1.223
Deubiquitination	R-HSA-5688426	5.996031e-02	1.222
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.186745e-02	1.209
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.186745e-02	1.209
Regulation of CDH19 Expression and Function	R-HSA-9764302	6.186745e-02	1.209
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.186745e-02	1.209
TGFBR3 expression	R-HSA-9839394	6.245427e-02	1.204
Interferon Signaling	R-HSA-913531	6.319588e-02	1.199
Cap-dependent Translation Initiation	R-HSA-72737	6.410787e-02	1.193
Eukaryotic Translation Initiation	R-HSA-72613	6.410787e-02	1.193
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	6.440377e-02	1.191
Sema3A PAK dependent Axon repulsion	R-HSA-399954	6.440377e-02	1.191
Nephrin family interactions	R-HSA-373753	6.448379e-02	1.191
MITF-M-dependent gene expression	R-HSA-9856651	6.493737e-02	1.188
Transcriptional Regulation by TP53	R-HSA-3700989	6.510708e-02	1.186
Estrogen-dependent gene expression	R-HSA-9018519	6.569870e-02	1.182
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.663905e-02	1.176
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	7.459511e-02	1.127
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	7.459511e-02	1.127
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	7.459511e-02	1.127
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	7.459511e-02	1.127
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	7.459511e-02	1.127
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	7.459511e-02	1.127
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	7.459511e-02	1.127
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	7.459511e-02	1.127
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	7.459511e-02	1.127
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	7.459511e-02	1.127
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	7.459511e-02	1.127
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	7.459511e-02	1.127
G2/M DNA replication checkpoint	R-HSA-69478	8.136130e-02	1.090
PECAM1 interactions	R-HSA-210990	7.397048e-02	1.131
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.397048e-02	1.131
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	7.628132e-02	1.118
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.118980e-02	1.148
Interaction between L1 and Ankyrins	R-HSA-445095	8.061441e-02	1.094
Formation of RNA Pol II elongation complex	R-HSA-112382	7.863970e-02	1.104
EPHB-mediated forward signaling	R-HSA-3928662	7.130473e-02	1.147
Integrin signaling	R-HSA-354192	7.521930e-02	1.124
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	8.558111e-02	1.068
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.049209e-02	1.152
Nef and signal transduction	R-HSA-164944	8.136130e-02	1.090
Regulation of NFE2L2 gene expression	R-HSA-9818749	8.136130e-02	1.090
MAPK family signaling cascades	R-HSA-5683057	7.084335e-02	1.150
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	8.485485e-02	1.071
Programmed Cell Death	R-HSA-5357801	7.442206e-02	1.128
Regulation of TP53 Activity	R-HSA-5633007	7.328006e-02	1.135
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	7.518004e-02	1.124
ChREBP activates metabolic gene expression	R-HSA-163765	7.397048e-02	1.131
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	8.061441e-02	1.094
SARS-CoV-2-host interactions	R-HSA-9705683	7.256014e-02	1.139
Glycolysis	R-HSA-70171	7.922259e-02	1.101
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.460695e-02	1.127
RNA Polymerase II Transcription Elongation	R-HSA-75955	8.575121e-02	1.067
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.575121e-02	1.067
Condensation of Prophase Chromosomes	R-HSA-2299718	8.608561e-02	1.065
Signaling by TGFBR3	R-HSA-9839373	8.608561e-02	1.065
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	8.678818e-02	1.062
Signaling by NTRKs	R-HSA-166520	8.712882e-02	1.060
Disorders of Developmental Biology	R-HSA-9675151	8.925666e-02	1.049
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	8.925666e-02	1.049
NF-kB is activated and signals survival	R-HSA-209560	8.964555e-02	1.047
Signaling by AXIN mutants	R-HSA-4839735	8.964555e-02	1.047
Signaling by AMER1 mutants	R-HSA-4839748	8.964555e-02	1.047
Oxidative Stress Induced Senescence	R-HSA-2559580	8.966234e-02	1.047
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	9.013417e-02	1.045
MAP kinase activation	R-HSA-450294	9.186328e-02	1.037
RNA Polymerase II Transcription Termination	R-HSA-73856	9.186328e-02	1.037
Signaling by ROBO receptors	R-HSA-376176	9.195051e-02	1.036
VEGFR2 mediated vascular permeability	R-HSA-5218920	9.426241e-02	1.026
Interleukin-12 signaling	R-HSA-9020591	9.462879e-02	1.024
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.701732e-02	1.013
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	9.739333e-02	1.011
NGF-stimulated transcription	R-HSA-9031628	1.025890e-01	0.989
Displacement of DNA glycosylase by APEX1	R-HSA-110357	1.031392e-01	0.987
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	1.031392e-01	0.987
NOSTRIN mediated eNOS trafficking	R-HSA-203641	1.031392e-01	0.987
SOS-mediated signalling	R-HSA-112412	1.031392e-01	0.987
Uptake and function of diphtheria toxin	R-HSA-5336415	1.031392e-01	0.987
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.032969e-01	0.986
Signaling by FGFR1 in disease	R-HSA-5655302	1.033987e-01	0.985
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.057625e-01	0.976
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.057625e-01	0.976
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.057625e-01	0.976
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.057625e-01	0.976
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.067696e-01	0.972
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.067696e-01	0.972
Repression of WNT target genes	R-HSA-4641265	1.067696e-01	0.972
Disorders of Nervous System Development	R-HSA-9697154	1.067696e-01	0.972
Pervasive developmental disorders	R-HSA-9005895	1.067696e-01	0.972
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.067696e-01	0.972
IRE1alpha activates chaperones	R-HSA-381070	1.081935e-01	0.966
MET interacts with TNS proteins	R-HSA-8875513	1.085409e-01	0.964
Invadopodia formation	R-HSA-8941237	1.085409e-01	0.964
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.085409e-01	0.964
Type I hemidesmosome assembly	R-HSA-446107	1.269328e-01	0.896
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.449566e-01	0.839
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.449566e-01	0.839
Retrograde neurotrophin signalling	R-HSA-177504	1.449566e-01	0.839
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	1.343878e-01	0.872
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.343878e-01	0.872
TRAF6 mediated NF-kB activation	R-HSA-933542	1.234460e-01	0.909
Activation of the pre-replicative complex	R-HSA-68962	1.129664e-01	0.947
SWI/SNF chromatin remodelers	R-HSA-9932451	1.376279e-01	0.861
ATP-dependent chromatin remodelers	R-HSA-9932444	1.376279e-01	0.861
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.195344e-01	0.923
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.117188e-01	0.952
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.447071e-01	0.840
G1/S Transition	R-HSA-69206	1.121152e-01	0.950
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.269328e-01	0.896
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.328832e-01	0.877
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.437716e-01	0.842
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.328832e-01	0.877
Golgi-to-ER retrograde transport	R-HSA-8856688	1.133345e-01	0.946
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.100237e-01	0.959
Cellular responses to mechanical stimuli	R-HSA-9855142	1.212154e-01	0.916
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.252441e-01	0.902
Signaling by Hedgehog	R-HSA-5358351	1.089797e-01	0.963
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.195344e-01	0.923
Platelet activation, signaling and aggregation	R-HSA-76002	1.229886e-01	0.910
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.234460e-01	0.909
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.406645e-01	0.852
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.117188e-01	0.952
Protein ubiquitination	R-HSA-8852135	1.448048e-01	0.839
Interleukin-37 signaling	R-HSA-9008059	1.129664e-01	0.947
Signaling by Interleukins	R-HSA-449147	1.098402e-01	0.959
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.336846e-01	0.874
XBP1(S) activates chaperone genes	R-HSA-381038	1.190600e-01	0.924
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.311995e-01	0.882
Interleukin-12 family signaling	R-HSA-447115	1.264485e-01	0.898
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.456596e-01	0.837
Regulation of gap junction activity	R-HSA-191650	1.456596e-01	0.837
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.456596e-01	0.837
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.456596e-01	0.837
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.456596e-01	0.837
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.456596e-01	0.837
MTF1 activates gene expression	R-HSA-5660489	1.456596e-01	0.837
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.456596e-01	0.837
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.461313e-01	0.835
MAPK1/MAPK3 signaling	R-HSA-5684996	1.472556e-01	0.832
TCF dependent signaling in response to WNT	R-HSA-201681	1.489185e-01	0.827
FGFR1 mutant receptor activation	R-HSA-1839124	1.511304e-01	0.821
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.511304e-01	0.821
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.513244e-01	0.820
Signal transduction by L1	R-HSA-445144	1.513244e-01	0.820
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	1.520124e-01	0.818
GP1b-IX-V activation signalling	R-HSA-430116	1.524593e-01	0.817
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.524593e-01	0.817
Inactivation of CDC42 and RAC1	R-HSA-428543	1.524593e-01	0.817
Calcineurin activates NFAT	R-HSA-2025928	1.524593e-01	0.817
Unwinding of DNA	R-HSA-176974	1.524593e-01	0.817
Myogenesis	R-HSA-525793	1.525322e-01	0.817
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.525322e-01	0.817
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.525322e-01	0.817
RAF/MAP kinase cascade	R-HSA-5673001	1.529565e-01	0.815
Response of endothelial cells to shear stress	R-HSA-9860931	1.534581e-01	0.814
Regulation of TNFR1 signaling	R-HSA-5357905	1.561719e-01	0.806
Epigenetic regulation of gene expression	R-HSA-212165	1.571555e-01	0.804
Transcriptional Regulation by MECP2	R-HSA-8986944	1.585497e-01	0.800
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.608819e-01	0.793
Interleukin-2 family signaling	R-HSA-451927	1.608819e-01	0.793
Transport to the Golgi and subsequent modification	R-HSA-948021	1.647902e-01	0.783
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.003449e-01	0.698
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.003449e-01	0.698
TICAM1 deficiency - HSE	R-HSA-5602566	2.003449e-01	0.698
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	2.003449e-01	0.698
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	2.003449e-01	0.698
IRS activation	R-HSA-74713	1.849013e-01	0.733
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	1.849013e-01	0.733
G2 Phase	R-HSA-68911	1.849013e-01	0.733
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.849013e-01	0.733
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.849013e-01	0.733
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.254023e-01	0.647
Pentose phosphate pathway disease	R-HSA-6791465	2.254023e-01	0.647
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.254023e-01	0.647
Noncanonical activation of NOTCH3	R-HSA-9017802	2.254023e-01	0.647
Phosphorylation of Emi1	R-HSA-176417	2.254023e-01	0.647
MET activates RAP1 and RAC1	R-HSA-8875555	1.794323e-01	0.746
Signaling by APC mutants	R-HSA-4839744	2.075700e-01	0.683
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.075700e-01	0.683
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.075700e-01	0.683
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.075700e-01	0.683
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.657849e-01	0.780
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	2.366011e-01	0.626
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	2.366011e-01	0.626
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.366011e-01	0.626
Signaling by GSK3beta mutants	R-HSA-5339716	2.366011e-01	0.626
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.102674e-01	0.677
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.681166e-01	0.774
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.681166e-01	0.774
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.336540e-01	0.631
Notch-HLH transcription pathway	R-HSA-350054	2.068750e-01	0.684
HIV elongation arrest and recovery	R-HSA-167287	1.843352e-01	0.734
Pausing and recovery of HIV elongation	R-HSA-167290	1.843352e-01	0.734
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.650381e-01	0.782
Interleukin receptor SHC signaling	R-HSA-912526	2.267167e-01	0.645
Regulation of gene expression in beta cells	R-HSA-210745	2.011386e-01	0.697
RAF activation	R-HSA-5673000	1.794899e-01	0.746
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.184749e-01	0.661
Deadenylation of mRNA	R-HSA-429947	2.470866e-01	0.607
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.098893e-01	0.678
EGFR downregulation	R-HSA-182971	2.362898e-01	0.627
HDACs deacetylate histones	R-HSA-3214815	1.734114e-01	0.761
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.700958e-01	0.769
Nucleosome assembly	R-HSA-774815	2.454327e-01	0.610
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.454327e-01	0.610
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.472993e-01	0.607
Formation of a pool of free 40S subunits	R-HSA-72689	2.138356e-01	0.670
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.349119e-01	0.629
RNA Polymerase III Transcription	R-HSA-74158	2.098893e-01	0.678
Ribosome-associated quality control	R-HSA-9948299	2.167492e-01	0.664
Early Phase of HIV Life Cycle	R-HSA-162594	1.691005e-01	0.772
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.681166e-01	0.774
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	2.427341e-01	0.615
DCC mediated attractive signaling	R-HSA-418885	1.657849e-01	0.780
Regulation of CDH11 function	R-HSA-9762292	1.794323e-01	0.746
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.075700e-01	0.683
Prolonged ERK activation events	R-HSA-169893	1.875995e-01	0.727
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	2.013578e-01	0.696
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	1.875995e-01	0.727
Killing mechanisms	R-HSA-9664420	1.875995e-01	0.727
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.040722e-01	0.690
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.254023e-01	0.647
Activation of HOX genes during differentiation	R-HSA-5619507	2.327910e-01	0.633
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.327910e-01	0.633
Interleukin-17 signaling	R-HSA-448424	1.700958e-01	0.769
Signal attenuation	R-HSA-74749	1.794323e-01	0.746
Integration of provirus	R-HSA-162592	2.366011e-01	0.626
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.011386e-01	0.697
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.254023e-01	0.647
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	2.336540e-01	0.631
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.336540e-01	0.631
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.680637e-01	0.775
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.013578e-01	0.696
Signaling by NOTCH1	R-HSA-1980143	2.358934e-01	0.627
p75NTR signals via NF-kB	R-HSA-193639	1.657849e-01	0.780
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	2.068750e-01	0.684
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	1.680637e-01	0.775
Signaling by EGFR	R-HSA-177929	1.850627e-01	0.733
Switching of origins to a post-replicative state	R-HSA-69052	2.018006e-01	0.695
Neurexins and neuroligins	R-HSA-6794361	2.332630e-01	0.632
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.739283e-01	0.760
Signalling to ERKs	R-HSA-187687	1.944523e-01	0.711
Vesicle-mediated transport	R-HSA-5653656	2.307199e-01	0.637
Activation of BH3-only proteins	R-HSA-114452	2.184749e-01	0.661
Formation of editosomes by ADAR proteins	R-HSA-77042	2.003449e-01	0.698
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	1.657849e-01	0.780
Differentiation of T cells	R-HSA-9945266	1.875995e-01	0.727
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	1.875995e-01	0.727
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.102674e-01	0.677
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	2.336540e-01	0.631
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.681166e-01	0.774
Netrin-1 signaling	R-HSA-373752	2.303893e-01	0.638
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.102674e-01	0.677
PIP3 activates AKT signaling	R-HSA-1257604	1.824514e-01	0.739
FLT3 signaling in disease	R-HSA-9682385	2.098893e-01	0.678
Intracellular signaling by second messengers	R-HSA-9006925	1.679143e-01	0.775
RET signaling	R-HSA-8853659	2.098893e-01	0.678
MAPK6/MAPK4 signaling	R-HSA-5687128	2.468647e-01	0.608
Josephin domain DUBs	R-HSA-5689877	1.794323e-01	0.746
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.102674e-01	0.677
Syndecan interactions	R-HSA-3000170	2.267167e-01	0.645
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.184749e-01	0.661
Transcriptional Regulation by VENTX	R-HSA-8853884	1.739283e-01	0.760
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.357275e-01	0.628
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	1.681166e-01	0.774
Glucose metabolism	R-HSA-70326	2.208900e-01	0.656
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	2.254023e-01	0.647
Signaling by Leptin	R-HSA-2586552	1.794323e-01	0.746
Gene Silencing by RNA	R-HSA-211000	1.861792e-01	0.730
SARS-CoV Infections	R-HSA-9679506	2.165212e-01	0.664
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.850627e-01	0.733
SARS-CoV-1 Infection	R-HSA-9678108	2.015266e-01	0.696
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	2.849283e-01	0.545
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	2.849283e-01	0.545
TRAF3 deficiency - HSE	R-HSA-5602571	2.849283e-01	0.545
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.849283e-01	0.545
Defective SLC17A5 causes Salla disease (SD) and ISSD	R-HSA-5619035	2.849283e-01	0.545
Defective SLC34A2 causes PALM	R-HSA-5687583	2.849283e-01	0.545
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	R-HSA-5619045	2.849283e-01	0.545
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.849283e-01	0.545
Defective VWF binding to collagen type I	R-HSA-9845622	2.849283e-01	0.545
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	2.849283e-01	0.545
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.849283e-01	0.545
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.849283e-01	0.545
Signaling by TCF7L2 mutants	R-HSA-5339700	2.849283e-01	0.545
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.605694e-01	0.443
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	3.605694e-01	0.443
Defective F8 sulfation at Y1699	R-HSA-9674519	3.605694e-01	0.443
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.605694e-01	0.443
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.605694e-01	0.443
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.605694e-01	0.443
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.605694e-01	0.443
Defective ABCD1 causes ALD	R-HSA-5684045	3.605694e-01	0.443
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.605694e-01	0.443
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.605694e-01	0.443
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	2.664577e-01	0.574
Autointegration results in viral DNA circles	R-HSA-177539	2.664577e-01	0.574
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.664577e-01	0.574
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.074977e-01	0.512
RUNX3 regulates WNT signaling	R-HSA-8951430	3.074977e-01	0.512
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.074977e-01	0.512
TRIF-mediated programmed cell death	R-HSA-2562578	3.074977e-01	0.512
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.074977e-01	0.512
Defective MMACHC causes MAHCC	R-HSA-3359474	4.282131e-01	0.368
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.282131e-01	0.368
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.282131e-01	0.368
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.282131e-01	0.368
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.282131e-01	0.368
MET activates PTPN11	R-HSA-8865999	4.282131e-01	0.368
MET activates RAS signaling	R-HSA-8851805	2.662697e-01	0.575
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.662697e-01	0.575
RUNX3 regulates p14-ARF	R-HSA-8951936	2.662697e-01	0.575
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.662697e-01	0.575
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.662697e-01	0.575
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.662697e-01	0.575
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.662697e-01	0.575
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.662697e-01	0.575
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.662697e-01	0.575
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	3.480664e-01	0.458
MET receptor recycling	R-HSA-8875656	3.480664e-01	0.458
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.480664e-01	0.458
Signaling by MRAS-complex mutants	R-HSA-9660537	3.480664e-01	0.458
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.480664e-01	0.458
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	2.963375e-01	0.528
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	2.963375e-01	0.528
CD28 dependent Vav1 pathway	R-HSA-389359	2.963375e-01	0.528
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	2.576258e-01	0.589
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.820519e-01	0.550
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.265862e-01	0.486
HCN channels	R-HSA-1296061	4.887044e-01	0.311
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.887044e-01	0.311
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.887044e-01	0.311
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.887044e-01	0.311
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.887044e-01	0.311
Signaling by MAP2K mutants	R-HSA-9652169	4.887044e-01	0.311
Defective LFNG causes SCDO3	R-HSA-5083630	4.887044e-01	0.311
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.545280e-01	0.594
Erythropoietin activates RAS	R-HSA-9027284	3.568183e-01	0.448
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.568183e-01	0.448
Beta-catenin phosphorylation cascade	R-HSA-196299	3.568183e-01	0.448
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.317667e-01	0.479
Binding and entry of HIV virion	R-HSA-173107	4.264343e-01	0.370
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.105487e-01	0.508
Striated Muscle Contraction	R-HSA-390522	2.920485e-01	0.535
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	3.568201e-01	0.448
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.322191e-01	0.479
Formation of the Early Elongation Complex	R-HSA-113418	3.322191e-01	0.479
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	3.112175e-01	0.507
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.909647e-01	0.536
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	3.279024e-01	0.484
Degradation of DVL	R-HSA-4641258	3.696939e-01	0.432
Signaling by EGFRvIII in Cancer	R-HSA-5637812	4.457523e-01	0.351
Constitutive Signaling by EGFRvIII	R-HSA-5637810	4.457523e-01	0.351
HSF1-dependent transactivation	R-HSA-3371571	3.410788e-01	0.467
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	2.631114e-01	0.580
Peptide chain elongation	R-HSA-156902	2.938420e-01	0.532
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	3.576121e-01	0.447
MET promotes cell motility	R-HSA-8875878	3.893313e-01	0.410
Regulation of endogenous retroelements	R-HSA-9842860	2.873399e-01	0.542
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	3.742279e-01	0.427
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.743564e-01	0.324
RNA Polymerase III Transcription Termination	R-HSA-73980	4.743564e-01	0.324
Transcriptional regulation by RUNX3	R-HSA-8878159	3.257855e-01	0.487
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.995119e-01	0.398
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.431450e-01	0.465
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	4.411085e-01	0.355
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	4.285234e-01	0.368
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.285234e-01	0.368
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.174832e-01	0.379
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	4.075809e-01	0.390
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.938800e-01	0.405
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	4.673012e-01	0.330
HIV Transcription Initiation	R-HSA-167161	4.673012e-01	0.330
RNA Polymerase II Transcription Initiation	R-HSA-75953	4.673012e-01	0.330
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.147523e-01	0.382
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.147523e-01	0.382
Regulation of RAS by GAPs	R-HSA-5658442	4.709765e-01	0.327
Neutrophil degranulation	R-HSA-6798695	4.874782e-01	0.312
Transcription of the HIV genome	R-HSA-167172	3.462621e-01	0.461
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.245169e-01	0.372
Chromosome Maintenance	R-HSA-73886	3.442082e-01	0.463
Nucleotide Excision Repair	R-HSA-5696398	4.355949e-01	0.361
HIV Transcription Elongation	R-HSA-167169	4.285234e-01	0.368
RNA Polymerase III Transcription Initiation	R-HSA-76046	3.758755e-01	0.425
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.739412e-01	0.324
Signaling by MET	R-HSA-6806834	3.964797e-01	0.402
FOXO-mediated transcription	R-HSA-9614085	2.548242e-01	0.594
PI3K/AKT Signaling in Cancer	R-HSA-2219528	4.067281e-01	0.391
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.457523e-01	0.351
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.356768e-01	0.474
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.916605e-01	0.535
Cyclin D associated events in G1	R-HSA-69231	3.635746e-01	0.439
G1 Phase	R-HSA-69236	3.635746e-01	0.439
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.285234e-01	0.368
Signaling by ERBB2	R-HSA-1227986	4.902984e-01	0.310
Developmental Cell Lineages	R-HSA-9734767	4.272042e-01	0.369
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.068059e-01	0.513
MyD88-independent TLR4 cascade	R-HSA-166166	2.947742e-01	0.531
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.947742e-01	0.531
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	2.963375e-01	0.528
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	3.696939e-01	0.432
G2/M DNA damage checkpoint	R-HSA-69473	4.345069e-01	0.362
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.411085e-01	0.355
Regulation of mitotic cell cycle	R-HSA-453276	3.902361e-01	0.409
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.902361e-01	0.409
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.818588e-01	0.418
Germ layer formation at gastrulation	R-HSA-9754189	2.820519e-01	0.550
TRAF3-dependent IRF activation pathway	R-HSA-918233	4.165471e-01	0.380
UCH proteinases	R-HSA-5689603	4.639099e-01	0.334
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.074977e-01	0.512
Downregulation of ERBB4 signaling	R-HSA-1253288	3.480664e-01	0.458
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.878046e-01	0.411
PI3K/AKT activation	R-HSA-198203	4.264343e-01	0.370
WNT5A-dependent internalization of FZD4	R-HSA-5099900	3.868572e-01	0.412
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.089570e-01	0.388
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.242573e-01	0.372
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.323286e-01	0.364
Eukaryotic Translation Elongation	R-HSA-156842	2.566725e-01	0.591
NTRK3 as a dependence receptor	R-HSA-9603505	2.849283e-01	0.545
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	2.662697e-01	0.575
VLDLR internalisation and degradation	R-HSA-8866427	2.662697e-01	0.575
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.480664e-01	0.458
Signaling by WNT in cancer	R-HSA-4791275	2.545280e-01	0.594
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.568201e-01	0.448
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.456854e-01	0.461
Budding and maturation of HIV virion	R-HSA-162588	3.977189e-01	0.400
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	3.097118e-01	0.509
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.898739e-01	0.310
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.097118e-01	0.509
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.442082e-01	0.463
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.083885e-01	0.511
Rap1 signalling	R-HSA-392517	2.820519e-01	0.550
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.837136e-01	0.315
RNA Polymerase I Transcription	R-HSA-73864	4.930445e-01	0.307
G2/M Checkpoints	R-HSA-69481	3.283654e-01	0.484
Generation of second messenger molecules	R-HSA-202433	2.756041e-01	0.560
Deadenylation-dependent mRNA decay	R-HSA-429914	3.364158e-01	0.473
Activation of NF-kappaB in B cells	R-HSA-1169091	4.885571e-01	0.311
Mitophagy	R-HSA-5205647	4.837136e-01	0.315
Frs2-mediated activation	R-HSA-170968	2.963375e-01	0.528
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.800045e-01	0.319
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.674449e-01	0.435
Activation of ATR in response to replication stress	R-HSA-176187	2.731332e-01	0.564
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.264343e-01	0.370
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	4.165471e-01	0.380
Formation of the posterior neural plate	R-HSA-9832991	4.637454e-01	0.334
DNA strand elongation	R-HSA-69190	4.194838e-01	0.377
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	3.755167e-01	0.425
Effects of PIP2 hydrolysis	R-HSA-114508	4.625361e-01	0.335
DNA Replication Pre-Initiation	R-HSA-69002	3.792119e-01	0.421
Negative regulation of MAPK pathway	R-HSA-5675221	3.102667e-01	0.508
Diseases associated with the TLR signaling cascade	R-HSA-5602358	2.756041e-01	0.560
Diseases of Immune System	R-HSA-5260271	2.756041e-01	0.560
Downregulation of ERBB2 signaling	R-HSA-8863795	3.758755e-01	0.425
TNF signaling	R-HSA-75893	2.909647e-01	0.536
Signaling by WNT	R-HSA-195721	4.922635e-01	0.308
Synthesis of DNA	R-HSA-69239	3.557365e-01	0.449
Regulation of beta-cell development	R-HSA-186712	4.739412e-01	0.324
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.615580e-01	0.582
CRMPs in Sema3A signaling	R-HSA-399956	3.265862e-01	0.486
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.887044e-01	0.311
Signaling by SCF-KIT	R-HSA-1433557	3.456854e-01	0.461
TCR signaling	R-HSA-202403	2.947742e-01	0.531
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.829356e-01	0.417
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.377385e-01	0.471
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.800045e-01	0.319
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.377385e-01	0.471
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.377385e-01	0.471
Gene expression (Transcription)	R-HSA-74160	4.100266e-01	0.387
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.479856e-01	0.349
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.792119e-01	0.421
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.820519e-01	0.550
Mismatch Repair	R-HSA-5358508	4.743564e-01	0.324
Cytosolic tRNA aminoacylation	R-HSA-379716	4.864303e-01	0.313
Assembly of the pre-replicative complex	R-HSA-68867	3.683902e-01	0.434
Signaling by NOTCH	R-HSA-157118	2.544431e-01	0.594
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	2.849283e-01	0.545
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.849283e-01	0.545
Transport of connexins along the secretory pathway	R-HSA-190827	2.849283e-01	0.545
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.849283e-01	0.545
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.849283e-01	0.545
Manipulation of host energy metabolism	R-HSA-9636667	2.849283e-01	0.545
mRNA Editing: A to I Conversion	R-HSA-75064	3.605694e-01	0.443
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.605694e-01	0.443
C6 deamination of adenosine	R-HSA-75102	3.605694e-01	0.443
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.605694e-01	0.443
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	2.664577e-01	0.574
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.664577e-01	0.574
Intracellular metabolism of fatty acids regulates insulin secretion	R-HSA-434313	2.664577e-01	0.574
Regulation of PTEN localization	R-HSA-8948747	3.074977e-01	0.512
MET activates STAT3	R-HSA-8875791	4.282131e-01	0.368
Type II Na+/Pi cotransporters	R-HSA-427589	4.282131e-01	0.368
Signaling by LTK	R-HSA-9842663	2.662697e-01	0.575
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.576258e-01	0.589
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	3.568183e-01	0.448
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.264343e-01	0.370
Class I peroxisomal membrane protein import	R-HSA-9603798	3.868572e-01	0.412
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	4.637454e-01	0.334
Bicarbonate transporters	R-HSA-425381	4.637454e-01	0.334
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.315035e-01	0.365
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.743564e-01	0.324
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.985572e-01	0.400
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	3.611188e-01	0.442
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.266422e-01	0.370
HCMV Late Events	R-HSA-9610379	4.907029e-01	0.309
Signaling by FGFR in disease	R-HSA-1226099	3.136094e-01	0.504
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.322191e-01	0.479
rRNA processing	R-HSA-72312	3.201486e-01	0.495
Ub-specific processing proteases	R-HSA-5689880	4.825326e-01	0.316
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	3.354166e-01	0.474
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.922971e-01	0.534
Receptor Mediated Mitophagy	R-HSA-8934903	4.264343e-01	0.370
DAG and IP3 signaling	R-HSA-1489509	3.815298e-01	0.418
TRP channels	R-HSA-3295583	4.800045e-01	0.319
Selenocysteine synthesis	R-HSA-2408557	4.834260e-01	0.316
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.731332e-01	0.564
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	4.428360e-01	0.354
HDMs demethylate histones	R-HSA-3214842	4.559353e-01	0.341
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.829356e-01	0.417
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.480664e-01	0.458
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.480664e-01	0.458
Regulated proteolysis of p75NTR	R-HSA-193692	3.878046e-01	0.411
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.887044e-01	0.311
Synthesis of PG	R-HSA-1483148	4.165471e-01	0.380
Protein-protein interactions at synapses	R-HSA-6794362	3.487812e-01	0.457
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.540191e-01	0.451
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.074977e-01	0.512
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	3.074977e-01	0.512
Regulation of KIT signaling	R-HSA-1433559	3.265862e-01	0.486
RUNX2 regulates bone development	R-HSA-8941326	3.500943e-01	0.456
FLT3 Signaling	R-HSA-9607240	2.928199e-01	0.533
Diseases of programmed cell death	R-HSA-9645723	4.019051e-01	0.396
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.941683e-01	0.306
Oligomerization of connexins into connexons	R-HSA-190704	2.849283e-01	0.545
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.664577e-01	0.574
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.282131e-01	0.368
Protein methylation	R-HSA-8876725	3.568183e-01	0.448
2-LTR circle formation	R-HSA-164843	4.264343e-01	0.370
Signaling by PDGFR in disease	R-HSA-9671555	3.568201e-01	0.448
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.963375e-01	0.528
Mitochondrial calcium ion transport	R-HSA-8949215	3.568201e-01	0.448
Cyclin E associated events during G1/S transition	R-HSA-69202	2.608882e-01	0.584
DNA Damage Bypass	R-HSA-73893	3.083885e-01	0.511
Viral Infection Pathways	R-HSA-9824446	3.141046e-01	0.503
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.568183e-01	0.448
Suppression of apoptosis	R-HSA-9635465	4.637454e-01	0.334
Signaling by ALK	R-HSA-201556	4.089570e-01	0.388
The NLRP3 inflammasome	R-HSA-844456	2.820519e-01	0.550
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.593174e-01	0.586
Signaling by NOTCH3	R-HSA-9012852	4.075809e-01	0.390
Formation of the anterior neural plate	R-HSA-9823739	3.568183e-01	0.448
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.868968e-01	0.542
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.074977e-01	0.512
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.878046e-01	0.411
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.887044e-01	0.311
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.264343e-01	0.370
EPHA-mediated growth cone collapse	R-HSA-3928663	3.105487e-01	0.508
Signaling by NOTCH4	R-HSA-9013694	3.136094e-01	0.504
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.479856e-01	0.349
Sensory processing of sound	R-HSA-9659379	3.824926e-01	0.417
Prostanoid ligand receptors	R-HSA-391908	4.637454e-01	0.334
Regulation of CDH11 gene transcription	R-HSA-9762293	3.878046e-01	0.411
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.605694e-01	0.443
Respiratory syncytial virus genome replication	R-HSA-9834752	3.878046e-01	0.411
Interleukin-1 processing	R-HSA-448706	3.878046e-01	0.411
Unfolded Protein Response (UPR)	R-HSA-381119	2.995016e-01	0.524
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.576258e-01	0.589
Mitochondrial biogenesis	R-HSA-1592230	4.976867e-01	0.303
Interleukin-2 signaling	R-HSA-9020558	4.637454e-01	0.334
Uptake and function of anthrax toxins	R-HSA-5210891	4.457523e-01	0.351
SARS-CoV-2 Infection	R-HSA-9694516	2.977674e-01	0.526
Synthesis of diphthamide-EEF2	R-HSA-5358493	4.995846e-01	0.301
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.995846e-01	0.301
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.995846e-01	0.301
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	4.995846e-01	0.301
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.995846e-01	0.301
Regulation of signaling by CBL	R-HSA-912631	5.022608e-01	0.299
E2F mediated regulation of DNA replication	R-HSA-113510	5.022608e-01	0.299
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.022608e-01	0.299
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.036447e-01	0.298
Regulation of Apoptosis	R-HSA-169911	5.045929e-01	0.297
Oncogene Induced Senescence	R-HSA-2559585	5.045929e-01	0.297
ESR-mediated signaling	R-HSA-8939211	5.049234e-01	0.297
RNA Polymerase II Promoter Escape	R-HSA-73776	5.053360e-01	0.296
TBC/RABGAPs	R-HSA-8854214	5.053360e-01	0.296
Orc1 removal from chromatin	R-HSA-68949	5.059619e-01	0.296
Uptake and actions of bacterial toxins	R-HSA-5339562	5.059619e-01	0.296
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.059619e-01	0.296
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	5.070090e-01	0.295
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.074663e-01	0.295
Potential therapeutics for SARS	R-HSA-9679191	5.106546e-01	0.292
Signaling by TGFB family members	R-HSA-9006936	5.210074e-01	0.283
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.210145e-01	0.283
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.210145e-01	0.283
Eukaryotic Translation Termination	R-HSA-72764	5.213215e-01	0.283
Meiotic synapsis	R-HSA-1221632	5.231632e-01	0.281
Regulation of PTEN stability and activity	R-HSA-8948751	5.231632e-01	0.281
RMTs methylate histone arginines	R-HSA-3214858	5.239842e-01	0.281
PRC2 methylates histones and DNA	R-HSA-212300	5.251304e-01	0.280
Lysosome Vesicle Biogenesis	R-HSA-432720	5.251304e-01	0.280
Calmodulin induced events	R-HSA-111933	5.251304e-01	0.280
CaM pathway	R-HSA-111997	5.251304e-01	0.280
Regulation of TP53 Degradation	R-HSA-6804757	5.251304e-01	0.280
Inflammasomes	R-HSA-622312	5.267975e-01	0.278
Negative regulation of MET activity	R-HSA-6807004	5.293841e-01	0.276
VxPx cargo-targeting to cilium	R-HSA-5620916	5.293841e-01	0.276
Co-inhibition by CTLA4	R-HSA-389513	5.293841e-01	0.276
Signaling by NODAL	R-HSA-1181150	5.293841e-01	0.276
Protein hydroxylation	R-HSA-9629569	5.293841e-01	0.276
Eicosanoid ligand-binding receptors	R-HSA-391903	5.293841e-01	0.276
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.338459e-01	0.273
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.338459e-01	0.273
p75NTR recruits signalling complexes	R-HSA-209543	5.338459e-01	0.273
Diseases associated with surfactant metabolism	R-HSA-5687613	5.338459e-01	0.273
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.338459e-01	0.273
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.338459e-01	0.273
IRAK1 recruits IKK complex	R-HSA-937039	5.338459e-01	0.273
Interleukin-15 signaling	R-HSA-8983432	5.338459e-01	0.273
OAS antiviral response	R-HSA-8983711	5.338459e-01	0.273
CLEC7A (Dectin-1) signaling	R-HSA-5607764	5.342458e-01	0.272
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.370500e-01	0.270
Signaling by PTK6	R-HSA-8848021	5.384192e-01	0.269
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.384192e-01	0.269
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.401355e-01	0.267
tRNA processing	R-HSA-72306	5.405338e-01	0.267
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.423437e-01	0.266
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	5.423437e-01	0.266
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	5.423437e-01	0.266
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.423437e-01	0.266
NOSIP mediated eNOS trafficking	R-HSA-203754	5.427994e-01	0.265
FLT3 signaling by CBL mutants	R-HSA-9706377	5.427994e-01	0.265
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.427994e-01	0.265
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.427994e-01	0.265
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.427994e-01	0.265
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.427994e-01	0.265
Muscarinic acetylcholine receptors	R-HSA-390648	5.427994e-01	0.265
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.427994e-01	0.265
Pyrophosphate hydrolysis	R-HSA-71737	5.427994e-01	0.265
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.427994e-01	0.265
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.427994e-01	0.265
Nectin/Necl trans heterodimerization	R-HSA-420597	5.427994e-01	0.265
Assembly of Viral Components at the Budding Site	R-HSA-168316	5.427994e-01	0.265
Platelet calcium homeostasis	R-HSA-418360	5.494122e-01	0.260
Termination of translesion DNA synthesis	R-HSA-5656169	5.494122e-01	0.260
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.540713e-01	0.256
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	5.554198e-01	0.255
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	5.554198e-01	0.255
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	5.556600e-01	0.255
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	5.556600e-01	0.255
TNFR1-induced proapoptotic signaling	R-HSA-5357786	5.556600e-01	0.255
Basigin interactions	R-HSA-210991	5.556600e-01	0.255
Signalling to RAS	R-HSA-167044	5.556600e-01	0.255
Zygotic genome activation (ZGA)	R-HSA-9819196	5.556600e-01	0.255
mRNA Splicing - Minor Pathway	R-HSA-72165	5.603859e-01	0.252
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	5.650269e-01	0.248
SLC-mediated transport of inorganic anions	R-HSA-9958790	5.650269e-01	0.248
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.664620e-01	0.247
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.664620e-01	0.247
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	5.664620e-01	0.247
Cellular response to hypoxia	R-HSA-1234174	5.694971e-01	0.245
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.714455e-01	0.243
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.714455e-01	0.243
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.810366e-01	0.236
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	5.810366e-01	0.236
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	5.810366e-01	0.236
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.810366e-01	0.236
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.810366e-01	0.236
Signaling by NTRK3 (TRKC)	R-HSA-9034015	5.810366e-01	0.236
Assembly Of The HIV Virion	R-HSA-175474	5.810366e-01	0.236
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	5.815601e-01	0.235
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.843207e-01	0.233
Regulation of TP53 Expression and Degradation	R-HSA-6806003	5.843207e-01	0.233
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.911739e-01	0.228
Plus-strand DNA synthesis	R-HSA-164525	5.911739e-01	0.228
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.911739e-01	0.228
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.911739e-01	0.228
Defective CSF2RB causes SMDP5	R-HSA-5688849	5.911739e-01	0.228
Defective CSF2RA causes SMDP4	R-HSA-5688890	5.911739e-01	0.228
Signaling by MAPK mutants	R-HSA-9652817	5.911739e-01	0.228
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.911739e-01	0.228
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.911739e-01	0.228
Synthesis of PS	R-HSA-1483101	5.911739e-01	0.228
Sodium-coupled phosphate cotransporters	R-HSA-427652	5.911739e-01	0.228
CLEC7A/inflammasome pathway	R-HSA-5660668	5.911739e-01	0.228
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.911739e-01	0.228
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	5.928613e-01	0.227
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	5.928613e-01	0.227
Gastrulation	R-HSA-9758941	5.932133e-01	0.227
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.949126e-01	0.226
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.954192e-01	0.225
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.973975e-01	0.224
Signaling by FGFR4 in disease	R-HSA-5655291	5.973975e-01	0.224
NRIF signals cell death from the nucleus	R-HSA-205043	5.973975e-01	0.224
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.973975e-01	0.224
Signal regulatory protein family interactions	R-HSA-391160	5.973975e-01	0.224
DNA Double Strand Break Response	R-HSA-5693606	5.996035e-01	0.222
Muscle contraction	R-HSA-397014	6.000997e-01	0.222
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.031413e-01	0.220
Attenuation phase	R-HSA-3371568	6.031413e-01	0.220
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.031413e-01	0.220
Formation of Incision Complex in GG-NER	R-HSA-5696395	6.031413e-01	0.220
Nuclear signaling by ERBB4	R-HSA-1251985	6.031413e-01	0.220
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.054748e-01	0.218
FGFR2 alternative splicing	R-HSA-6803529	6.054748e-01	0.218
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	6.054748e-01	0.218
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.054748e-01	0.218
RAF-independent MAPK1/3 activation	R-HSA-112409	6.054748e-01	0.218
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.054748e-01	0.218
LDL clearance	R-HSA-8964038	6.054748e-01	0.218
Degradation of CDH1	R-HSA-9766229	6.123674e-01	0.213
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.136296e-01	0.212
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.173254e-01	0.209
Viral mRNA Translation	R-HSA-192823	6.209002e-01	0.207
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	6.214666e-01	0.207
PCP/CE pathway	R-HSA-4086400	6.225041e-01	0.206
RNA Polymerase II Transcription	R-HSA-73857	6.225332e-01	0.206
Interleukin-1 family signaling	R-HSA-446652	6.227876e-01	0.206
Spry regulation of FGF signaling	R-HSA-1295596	6.266429e-01	0.203
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	6.266429e-01	0.203
Processive synthesis on the lagging strand	R-HSA-69183	6.266429e-01	0.203
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.266429e-01	0.203
Signaling by Activin	R-HSA-1502540	6.266429e-01	0.203
p38MAPK events	R-HSA-171007	6.266429e-01	0.203
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.266429e-01	0.203
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.289469e-01	0.201
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.289469e-01	0.201
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	6.289469e-01	0.201
Free fatty acids regulate insulin secretion	R-HSA-400451	6.289469e-01	0.201
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	6.289469e-01	0.201
Growth hormone receptor signaling	R-HSA-982772	6.289469e-01	0.201
DNA Replication	R-HSA-69306	6.324224e-01	0.199
G-protein beta:gamma signalling	R-HSA-397795	6.337272e-01	0.198
Signaling by LTK in cancer	R-HSA-9842640	6.344327e-01	0.198
Erythropoietin activates STAT5	R-HSA-9027283	6.344327e-01	0.198
STAT5 Activation	R-HSA-9645135	6.344327e-01	0.198
Uncoating of the HIV Virion	R-HSA-162585	6.344327e-01	0.198
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	6.344327e-01	0.198
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.344327e-01	0.198
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	6.344327e-01	0.198
MET Receptor Activation	R-HSA-6806942	6.344327e-01	0.198
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	6.344327e-01	0.198
Abacavir transmembrane transport	R-HSA-2161517	6.344327e-01	0.198
Leukotriene receptors	R-HSA-391906	6.344327e-01	0.198
CREB3 factors activate genes	R-HSA-8874211	6.344327e-01	0.198
Neurofascin interactions	R-HSA-447043	6.344327e-01	0.198
Defective factor VIII causes hemophilia A	R-HSA-9662001	6.344327e-01	0.198
C-type lectin receptors (CLRs)	R-HSA-5621481	6.362580e-01	0.196
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	6.392776e-01	0.194
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.392776e-01	0.194
Intra-Golgi traffic	R-HSA-6811438	6.392776e-01	0.194
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	6.450392e-01	0.190
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	6.490784e-01	0.188
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	6.505875e-01	0.187
PLC beta mediated events	R-HSA-112043	6.507933e-01	0.187
PPARA activates gene expression	R-HSA-1989781	6.513306e-01	0.186
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.514354e-01	0.186
Thromboxane signalling through TP receptor	R-HSA-428930	6.514354e-01	0.186
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.531361e-01	0.185
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.531361e-01	0.185
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	6.531361e-01	0.185
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.542094e-01	0.184
Defective GALNT3 causes HFTC	R-HSA-5083625	6.542094e-01	0.184
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.542094e-01	0.184
Regulation of NF-kappa B signaling	R-HSA-9758274	6.542094e-01	0.184
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.542094e-01	0.184
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.542094e-01	0.184
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.542094e-01	0.184
Induction of Cell-Cell Fusion	R-HSA-9733458	6.542094e-01	0.184
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.542094e-01	0.184
ER-Phagosome pathway	R-HSA-1236974	6.551820e-01	0.184
Hedgehog 'on' state	R-HSA-5632684	6.564472e-01	0.183
Ca-dependent events	R-HSA-111996	6.565593e-01	0.183
Processing of DNA double-strand break ends	R-HSA-5693607	6.619612e-01	0.179
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	6.629380e-01	0.179
NCAM signaling for neurite out-growth	R-HSA-375165	6.652471e-01	0.177
Maternal to zygotic transition (MZT)	R-HSA-9816359	6.670525e-01	0.176
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.718439e-01	0.173
Dual Incision in GG-NER	R-HSA-5696400	6.718439e-01	0.173
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.718439e-01	0.173
Signaling by NOTCH2	R-HSA-1980145	6.718439e-01	0.173
NOD1/2 Signaling Pathway	R-HSA-168638	6.718439e-01	0.173
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.718439e-01	0.173
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.729319e-01	0.172
Long-term potentiation	R-HSA-9620244	6.729319e-01	0.172
Acyl chain remodelling of PS	R-HSA-1482801	6.729319e-01	0.172
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	6.729319e-01	0.172
CHL1 interactions	R-HSA-447041	6.731165e-01	0.172
MET activates PI3K/AKT signaling	R-HSA-8851907	6.731165e-01	0.172
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	R-HSA-964827	6.731165e-01	0.172
IFNG signaling activates MAPKs	R-HSA-9732724	6.731165e-01	0.172
Recycling of eIF2:GDP	R-HSA-72731	6.731165e-01	0.172
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	6.731165e-01	0.172
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.731165e-01	0.172
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	6.731165e-01	0.172
PTK6 Expression	R-HSA-8849473	6.731165e-01	0.172
Reuptake of GABA	R-HSA-888593	6.731165e-01	0.172
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.731165e-01	0.172
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.731165e-01	0.172
VLDL clearance	R-HSA-8964046	6.731165e-01	0.172
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.731165e-01	0.172
Cation-coupled Chloride cotransporters	R-HSA-426117	6.731165e-01	0.172
Maturation of replicase proteins	R-HSA-9694301	6.731165e-01	0.172
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	6.759909e-01	0.170
Cellular response to chemical stress	R-HSA-9711123	6.760058e-01	0.170
Pre-NOTCH Transcription and Translation	R-HSA-1912408	6.792069e-01	0.168
rRNA modification in the nucleus and cytosol	R-HSA-6790901	6.793282e-01	0.168
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.801249e-01	0.167
Coenzyme A biosynthesis	R-HSA-196783	6.801249e-01	0.167
Acetylcholine regulates insulin secretion	R-HSA-399997	6.801249e-01	0.167
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.801249e-01	0.167
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.801249e-01	0.167
Response to metal ions	R-HSA-5660526	6.801249e-01	0.167
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	6.870821e-01	0.163
Proteasome assembly	R-HSA-9907900	6.894911e-01	0.161
MET activates PTK2 signaling	R-HSA-8874081	6.934358e-01	0.159
Signaling by EGFR in Cancer	R-HSA-1643713	6.934358e-01	0.159
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	6.934358e-01	0.159
Signaling by ERBB4	R-HSA-1236394	6.958055e-01	0.158
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	6.970172e-01	0.157
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	6.970172e-01	0.157
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	6.970172e-01	0.157
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.989074e-01	0.156
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.044301e-01	0.152
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	7.044301e-01	0.152
Glycogen storage diseases	R-HSA-3229121	7.044301e-01	0.152
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.044301e-01	0.152
Asymmetric localization of PCP proteins	R-HSA-4608870	7.051268e-01	0.152
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	7.051268e-01	0.152
Interleukin-1 signaling	R-HSA-9020702	7.056157e-01	0.151
HSF1 activation	R-HSA-3371511	7.071291e-01	0.151
Reverse Transcription of HIV RNA	R-HSA-162589	7.077088e-01	0.150
Minus-strand DNA synthesis	R-HSA-164516	7.077088e-01	0.150
RSK activation	R-HSA-444257	7.077088e-01	0.150
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.077088e-01	0.150
Adrenoceptors	R-HSA-390696	7.077088e-01	0.150
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.077088e-01	0.150
Regulation by c-FLIP	R-HSA-3371378	7.077088e-01	0.150
FGFR1b ligand binding and activation	R-HSA-190370	7.077088e-01	0.150
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	7.077088e-01	0.150
SLC-mediated bile acid transport	R-HSA-9958517	7.077088e-01	0.150
TGFBR3 PTM regulation	R-HSA-9839383	7.077088e-01	0.150
Dimerization of procaspase-8	R-HSA-69416	7.077088e-01	0.150
Sodium/Proton exchangers	R-HSA-425986	7.077088e-01	0.150
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.082632e-01	0.150
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.082632e-01	0.150
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	7.094034e-01	0.149
Homology Directed Repair	R-HSA-5693538	7.125810e-01	0.147
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.129534e-01	0.147
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.129534e-01	0.147
DNA Double-Strand Break Repair	R-HSA-5693532	7.179876e-01	0.144
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.190431e-01	0.143
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.190431e-01	0.143
Degradation of AXIN	R-HSA-4641257	7.237037e-01	0.140
Regulation of PD-L1(CD274) expression	R-HSA-9909648	7.252292e-01	0.140
DNA Repair	R-HSA-73894	7.264480e-01	0.139
Tie2 Signaling	R-HSA-210993	7.271755e-01	0.138
GAB1 signalosome	R-HSA-180292	7.271755e-01	0.138
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.314968e-01	0.136
Telomere Extension By Telomerase	R-HSA-171319	7.314968e-01	0.136
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.314968e-01	0.136
HDR through Homologous Recombination (HRR)	R-HSA-5685942	7.318095e-01	0.136
G-protein mediated events	R-HSA-112040	7.318095e-01	0.136
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.347231e-01	0.134
ARMS-mediated activation	R-HSA-170984	7.386422e-01	0.132
Interleukin-21 signaling	R-HSA-9020958	7.386422e-01	0.132
Lipophagy	R-HSA-9613354	7.386422e-01	0.132
MAPK1 (ERK2) activation	R-HSA-112411	7.386422e-01	0.132
CASP8 activity is inhibited	R-HSA-5218900	7.386422e-01	0.132
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.386422e-01	0.132
p75NTR regulates axonogenesis	R-HSA-193697	7.386422e-01	0.132
mRNA Editing	R-HSA-75072	7.386422e-01	0.132
Regulation of signaling by NODAL	R-HSA-1433617	7.386422e-01	0.132
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.386422e-01	0.132
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.386422e-01	0.132
Cellular response to mitochondrial stress	R-HSA-9840373	7.386422e-01	0.132
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.386422e-01	0.132
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	7.395704e-01	0.131
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.395704e-01	0.131
Pyruvate metabolism	R-HSA-70268	7.440224e-01	0.128
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	7.449948e-01	0.128
Dual incision in TC-NER	R-HSA-6782135	7.454476e-01	0.128
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.484189e-01	0.126
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.484189e-01	0.126
Diseases of hemostasis	R-HSA-9671793	7.484189e-01	0.126
Translesion Synthesis by POLH	R-HSA-110320	7.484189e-01	0.126
STING mediated induction of host immune responses	R-HSA-1834941	7.484189e-01	0.126
Co-stimulation by CD28	R-HSA-389356	7.486849e-01	0.126
Signaling by Erythropoietin	R-HSA-9006335	7.490832e-01	0.125
Signaling by ERBB2 KD Mutants	R-HSA-9664565	7.490832e-01	0.125
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.490832e-01	0.125
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.490832e-01	0.125
mRNA Capping	R-HSA-72086	7.490832e-01	0.125
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	7.547365e-01	0.122
Plasma lipoprotein clearance	R-HSA-8964043	7.547365e-01	0.122
Stabilization of p53	R-HSA-69541	7.547365e-01	0.122
Extension of Telomeres	R-HSA-180786	7.579594e-01	0.120
Cellular response to starvation	R-HSA-9711097	7.585374e-01	0.120
Telomere Maintenance	R-HSA-157579	7.647526e-01	0.116
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.654402e-01	0.116
DAP12 signaling	R-HSA-2424491	7.657338e-01	0.116
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	7.657338e-01	0.116
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.657338e-01	0.116
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.663036e-01	0.116
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.663036e-01	0.116
Folding of actin by CCT/TriC	R-HSA-390450	7.663036e-01	0.116
Apoptosis induced DNA fragmentation	R-HSA-140342	7.663036e-01	0.116
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.663036e-01	0.116
DNA replication initiation	R-HSA-68952	7.663036e-01	0.116
EGFR Transactivation by Gastrin	R-HSA-2179392	7.663036e-01	0.116
Pexophagy	R-HSA-9664873	7.663036e-01	0.116
MAPK3 (ERK1) activation	R-HSA-110056	7.663036e-01	0.116
Interleukin-27 signaling	R-HSA-9020956	7.663036e-01	0.116
Maturation of spike protein	R-HSA-9683686	7.663036e-01	0.116
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.682236e-01	0.115
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.682236e-01	0.115
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.682236e-01	0.115
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.682236e-01	0.115
Glycogen synthesis	R-HSA-3322077	7.682236e-01	0.115
Generic Transcription Pathway	R-HSA-212436	7.691264e-01	0.114
Glycogen metabolism	R-HSA-8982491	7.692116e-01	0.114
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.692116e-01	0.114
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.700137e-01	0.114
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.700137e-01	0.114
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.700137e-01	0.114
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.700137e-01	0.114
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.700137e-01	0.114
tRNA Aminoacylation	R-HSA-379724	7.700137e-01	0.114
Downstream TCR signaling	R-HSA-202424	7.746695e-01	0.111
Trafficking of AMPA receptors	R-HSA-399719	7.814733e-01	0.107
Evasion by RSV of host interferon responses	R-HSA-9833109	7.814733e-01	0.107
Downstream signal transduction	R-HSA-186763	7.814733e-01	0.107
Hh mutants are degraded by ERAD	R-HSA-5362768	7.830082e-01	0.106
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	7.830082e-01	0.106
Stimuli-sensing channels	R-HSA-2672351	7.831320e-01	0.106
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.866559e-01	0.104
Lagging Strand Synthesis	R-HSA-69186	7.866559e-01	0.104
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.866559e-01	0.104
ERK/MAPK targets	R-HSA-198753	7.866559e-01	0.104
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.866559e-01	0.104
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.866559e-01	0.104
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	7.867604e-01	0.104
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.910388e-01	0.102
Activated NTRK3 signals through RAS	R-HSA-9034864	7.910388e-01	0.102
vRNP Assembly	R-HSA-192905	7.910388e-01	0.102
RHOBTB3 ATPase cycle	R-HSA-9706019	7.910388e-01	0.102
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	7.910388e-01	0.102
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	7.910388e-01	0.102
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.910388e-01	0.102
Dissolution of Fibrin Clot	R-HSA-75205	7.910388e-01	0.102
Toll-like Receptor Cascades	R-HSA-168898	7.925768e-01	0.101
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.961403e-01	0.099
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.961403e-01	0.099
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.961403e-01	0.099
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.963291e-01	0.099
Selenoamino acid metabolism	R-HSA-2408522	8.018576e-01	0.096
G1/S DNA Damage Checkpoints	R-HSA-69615	8.034774e-01	0.095
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.037845e-01	0.095
Cleavage of the damaged pyrimidine	R-HSA-110329	8.086240e-01	0.092
Depyrimidination	R-HSA-73928	8.086240e-01	0.092
Negative regulation of FGFR1 signaling	R-HSA-5654726	8.103308e-01	0.091
Regulation of necroptotic cell death	R-HSA-5675482	8.103308e-01	0.091
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.103308e-01	0.091
Nuclear RNA decay	R-HSA-9930044	8.103308e-01	0.091
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.103308e-01	0.091
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	8.131572e-01	0.090
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	8.131572e-01	0.090
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.131572e-01	0.090
Proton-coupled monocarboxylate transport	R-HSA-433692	8.131572e-01	0.090
Activated NTRK2 signals through RAS	R-HSA-9026519	8.131572e-01	0.090
Sensing of DNA Double Strand Breaks	R-HSA-5693548	8.131572e-01	0.090
Anchoring fibril formation	R-HSA-2214320	8.131572e-01	0.090
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.184941e-01	0.087
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	8.196787e-01	0.086
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.196787e-01	0.086
Signaling by KIT in disease	R-HSA-9669938	8.196787e-01	0.086
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.196787e-01	0.086
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.196787e-01	0.086
Signaling by FGFR4	R-HSA-5654743	8.204767e-01	0.086
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.204767e-01	0.086
Defective pyroptosis	R-HSA-9710421	8.204767e-01	0.086
SLC transporter disorders	R-HSA-5619102	8.213270e-01	0.085
Resolution of D-Loop Structures	R-HSA-5693537	8.235095e-01	0.084
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.235095e-01	0.084
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.235095e-01	0.084
Vpu mediated degradation of CD4	R-HSA-180534	8.235095e-01	0.084
Reproduction	R-HSA-1474165	8.283931e-01	0.082
Transmission across Chemical Synapses	R-HSA-112315	8.294304e-01	0.081
Surfactant metabolism	R-HSA-5683826	8.317169e-01	0.080
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.329356e-01	0.079
GRB2 events in EGFR signaling	R-HSA-179812	8.329356e-01	0.079
Scavenging by Class F Receptors	R-HSA-3000484	8.329356e-01	0.079
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.329356e-01	0.079
SHC-related events triggered by IGF1R	R-HSA-2428933	8.329356e-01	0.079
Leading Strand Synthesis	R-HSA-69109	8.329356e-01	0.079
Regulation of IFNG signaling	R-HSA-877312	8.329356e-01	0.079
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.329356e-01	0.079
Maple Syrup Urine Disease	R-HSA-9865114	8.329356e-01	0.079
Polymerase switching	R-HSA-69091	8.329356e-01	0.079
Interleukin-35 Signalling	R-HSA-8984722	8.329356e-01	0.079
Termination of O-glycan biosynthesis	R-HSA-977068	8.344080e-01	0.079
ABC transporters in lipid homeostasis	R-HSA-1369062	8.344080e-01	0.079
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.344080e-01	0.079
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	8.358600e-01	0.078
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.358977e-01	0.078
eNOS activation	R-HSA-203615	8.358977e-01	0.078
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.358977e-01	0.078
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.358977e-01	0.078
Signal amplification	R-HSA-392518	8.358977e-01	0.078
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.358977e-01	0.078
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.358977e-01	0.078
Signaling by FGFR1	R-HSA-5654736	8.411303e-01	0.075
Ion homeostasis	R-HSA-5578775	8.411303e-01	0.075
Signaling by FGFR3	R-HSA-5654741	8.423642e-01	0.075
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.423642e-01	0.075
Integrin cell surface interactions	R-HSA-216083	8.442246e-01	0.074
Co-inhibition by PD-1	R-HSA-389948	8.452063e-01	0.073
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	8.475285e-01	0.072
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.475285e-01	0.072
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.475285e-01	0.072
PERK regulates gene expression	R-HSA-381042	8.475285e-01	0.072
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.480408e-01	0.072
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.480408e-01	0.072
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.480408e-01	0.072
IRS-mediated signalling	R-HSA-112399	8.504350e-01	0.070
Adenylate cyclase activating pathway	R-HSA-170660	8.506213e-01	0.070
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.506213e-01	0.070
Platelet Adhesion to exposed collagen	R-HSA-75892	8.506213e-01	0.070
FGFR1c ligand binding and activation	R-HSA-190373	8.506213e-01	0.070
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.506213e-01	0.070
Processing of SMDT1	R-HSA-8949664	8.506213e-01	0.070
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.506213e-01	0.070
Maturation of nucleoprotein	R-HSA-9683610	8.506213e-01	0.070
Interleukin-6 signaling	R-HSA-1059683	8.506213e-01	0.070
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.506213e-01	0.070
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.524388e-01	0.069
Regulation of pyruvate metabolism	R-HSA-9861718	8.524388e-01	0.069
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.524388e-01	0.069
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.524388e-01	0.069
Diseases of DNA repair	R-HSA-9675135	8.524388e-01	0.069
Post-translational protein phosphorylation	R-HSA-8957275	8.575405e-01	0.067
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.584355e-01	0.066
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.584355e-01	0.066
GPVI-mediated activation cascade	R-HSA-114604	8.584355e-01	0.066
Glycosphingolipid transport	R-HSA-9845576	8.584355e-01	0.066
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.592826e-01	0.066
Signaling by FGFR2	R-HSA-5654738	8.599255e-01	0.066
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.606441e-01	0.065
FRS-mediated FGFR1 signaling	R-HSA-5654693	8.606441e-01	0.065
Tight junction interactions	R-HSA-420029	8.606441e-01	0.065
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.606441e-01	0.065
Hyaluronan degradation	R-HSA-2160916	8.606441e-01	0.065
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.606441e-01	0.065
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.606441e-01	0.065
Interleukin-7 signaling	R-HSA-1266695	8.606441e-01	0.065
Antigen processing-Cross presentation	R-HSA-1236975	8.607615e-01	0.065
Base Excision Repair	R-HSA-73884	8.618255e-01	0.065
Synthesis of PC	R-HSA-1483191	8.619615e-01	0.065
Removal of the Flap Intermediate	R-HSA-69166	8.664358e-01	0.062
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.664358e-01	0.062
N-glycan trimming and elongation in the cis-Golgi	R-HSA-964739	8.664358e-01	0.062
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.664358e-01	0.062
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.664358e-01	0.062
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	8.664358e-01	0.062
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.664358e-01	0.062
Prolactin receptor signaling	R-HSA-1170546	8.664358e-01	0.062
Malate-aspartate shuttle	R-HSA-9856872	8.664358e-01	0.062
Ciprofloxacin ADME	R-HSA-9793528	8.664358e-01	0.062
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.664358e-01	0.062
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.676877e-01	0.062
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.686522e-01	0.061
TRAF6 mediated IRF7 activation	R-HSA-933541	8.686522e-01	0.061
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.686522e-01	0.061
Beta-catenin independent WNT signaling	R-HSA-3858494	8.712428e-01	0.060
Metalloprotease DUBs	R-HSA-5689901	8.722831e-01	0.059
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.722831e-01	0.059
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.722831e-01	0.059
Abacavir ADME	R-HSA-2161522	8.722831e-01	0.059
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.722831e-01	0.059
NoRC negatively regulates rRNA expression	R-HSA-427413	8.742474e-01	0.058
Transcriptional regulation by RUNX2	R-HSA-8878166	8.759389e-01	0.058
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.766063e-01	0.057
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.777713e-01	0.057
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.782123e-01	0.056
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	8.794355e-01	0.056
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	8.794355e-01	0.056
p53-Dependent G1 DNA Damage Response	R-HSA-69563	8.794355e-01	0.056
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.805768e-01	0.055
Adenylate cyclase inhibitory pathway	R-HSA-170670	8.805768e-01	0.055
RNA Polymerase III Chain Elongation	R-HSA-73780	8.805768e-01	0.055
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.805768e-01	0.055
Telomere C-strand synthesis initiation	R-HSA-174430	8.805768e-01	0.055
SHC1 events in EGFR signaling	R-HSA-180336	8.805768e-01	0.055
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.805768e-01	0.055
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.805768e-01	0.055
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.805768e-01	0.055
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.805768e-01	0.055
Cytoprotection by HMOX1	R-HSA-9707564	8.810318e-01	0.055
Packaging Of Telomere Ends	R-HSA-171306	8.830206e-01	0.054
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.830206e-01	0.054
RNA Polymerase I Transcription Termination	R-HSA-73863	8.830206e-01	0.054
Signaling by FGFR3 in disease	R-HSA-5655332	8.830206e-01	0.054
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.830206e-01	0.054
IRS-related events triggered by IGF1R	R-HSA-2428928	8.832297e-01	0.054
Formation of paraxial mesoderm	R-HSA-9793380	8.832297e-01	0.054
Pentose phosphate pathway	R-HSA-71336	8.871488e-01	0.052
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.871488e-01	0.052
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.871488e-01	0.052
Signaling by FGFR2 in disease	R-HSA-5655253	8.874294e-01	0.052
PI3K Cascade	R-HSA-109704	8.874294e-01	0.052
Pre-NOTCH Expression and Processing	R-HSA-1912422	8.902193e-01	0.051
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.903969e-01	0.050
Signaling by PDGF	R-HSA-186797	8.903969e-01	0.050
Leishmania phagocytosis	R-HSA-9664417	8.916312e-01	0.050
FCGR3A-mediated phagocytosis	R-HSA-9664422	8.916312e-01	0.050
Parasite infection	R-HSA-9664407	8.916312e-01	0.050
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.929170e-01	0.049
Phase 0 - rapid depolarisation	R-HSA-5576892	8.929170e-01	0.049
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.929170e-01	0.049
Pyrimidine salvage	R-HSA-73614	8.929170e-01	0.049
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.932214e-01	0.049
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.932214e-01	0.049
Negative regulation of FLT3	R-HSA-9706369	8.932214e-01	0.049
Fructose catabolism	R-HSA-70350	8.932214e-01	0.049
Attachment and Entry	R-HSA-9678110	8.932214e-01	0.049
Virus Assembly and Release	R-HSA-168268	8.932214e-01	0.049
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.935564e-01	0.049
Meiosis	R-HSA-1500620	8.935757e-01	0.049
Hedgehog ligand biogenesis	R-HSA-5358346	8.949563e-01	0.048
Translation	R-HSA-72766	8.986471e-01	0.046
RSV-host interactions	R-HSA-9833110	8.995315e-01	0.046
DNA methylation	R-HSA-5334118	9.020300e-01	0.045
Impaired BRCA2 binding to RAD51	R-HSA-9709570	9.020300e-01	0.045
Downstream signaling of activated FGFR3	R-HSA-5654708	9.020300e-01	0.045
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.020371e-01	0.045
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.032804e-01	0.044
Insulin receptor signalling cascade	R-HSA-74751	9.035997e-01	0.044
IGF1R signaling cascade	R-HSA-2428924	9.035997e-01	0.044
Signaling by Nuclear Receptors	R-HSA-9006931	9.039607e-01	0.044
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	9.045278e-01	0.044
G beta:gamma signalling through CDC42	R-HSA-8964616	9.045278e-01	0.044
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	9.045278e-01	0.044
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.045278e-01	0.044
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	9.045278e-01	0.044
Passive transport by Aquaporins	R-HSA-432047	9.045278e-01	0.044
Fibronectin matrix formation	R-HSA-1566977	9.045278e-01	0.044
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.045278e-01	0.044
tRNA modification in the mitochondrion	R-HSA-6787450	9.045278e-01	0.044
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.045278e-01	0.044
Adaptive Immune System	R-HSA-1280218	9.057987e-01	0.043
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.096656e-01	0.041
Downstream signaling of activated FGFR4	R-HSA-5654716	9.104145e-01	0.041
Degradation of CRY and PER proteins	R-HSA-9932298	9.105384e-01	0.041
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.105384e-01	0.041
Regulation of T cell activation by CD28 family	R-HSA-388841	9.134604e-01	0.039
Hemostasis	R-HSA-109582	9.138593e-01	0.039
PI3K events in ERBB2 signaling	R-HSA-1963642	9.146377e-01	0.039
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.146377e-01	0.039
Choline catabolism	R-HSA-6798163	9.146377e-01	0.039
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.146377e-01	0.039
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.149433e-01	0.039
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.172982e-01	0.037
Nuclear Receptor transcription pathway	R-HSA-383280	9.173506e-01	0.037
Molecules associated with elastic fibres	R-HSA-2129379	9.181225e-01	0.037
Rab regulation of trafficking	R-HSA-9007101	9.185868e-01	0.037
Signaling by FGFR	R-HSA-190236	9.189432e-01	0.037
Integration of energy metabolism	R-HSA-163685	9.199008e-01	0.036
Response of Mtb to phagocytosis	R-HSA-9637690	9.235888e-01	0.035
G beta:gamma signalling through PLC beta	R-HSA-418217	9.236775e-01	0.034
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.236775e-01	0.034
Presynaptic function of Kainate receptors	R-HSA-500657	9.236775e-01	0.034
PKA activation in glucagon signalling	R-HSA-164378	9.236775e-01	0.034
Platelet sensitization by LDL	R-HSA-432142	9.236775e-01	0.034
FGFR1 ligand binding and activation	R-HSA-190242	9.236775e-01	0.034
PKA activation	R-HSA-163615	9.236775e-01	0.034
Synaptic adhesion-like molecules	R-HSA-8849932	9.236775e-01	0.034
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.236775e-01	0.034
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.236775e-01	0.034
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.252033e-01	0.034
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.256029e-01	0.034
Interferon gamma signaling	R-HSA-877300	9.289137e-01	0.032
DAP12 interactions	R-HSA-2172127	9.294382e-01	0.032
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.294382e-01	0.032
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.303115e-01	0.031
Synthesis of PA	R-HSA-1483166	9.314624e-01	0.031
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	9.317032e-01	0.031
Cardiogenesis	R-HSA-9733709	9.317032e-01	0.031
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.317605e-01	0.031
PI-3K cascade:FGFR3	R-HSA-5654710	9.317605e-01	0.031
Crosslinking of collagen fibrils	R-HSA-2243919	9.317605e-01	0.031
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.317605e-01	0.031
Pyrimidine biosynthesis	R-HSA-500753	9.317605e-01	0.031
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.317605e-01	0.031
Other interleukin signaling	R-HSA-449836	9.317605e-01	0.031
Maturation of nucleoprotein	R-HSA-9694631	9.317605e-01	0.031
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.317605e-01	0.031
Somitogenesis	R-HSA-9824272	9.348731e-01	0.029
PI Metabolism	R-HSA-1483255	9.353260e-01	0.029
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.362876e-01	0.029
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.365002e-01	0.028
Miscellaneous transport and binding events	R-HSA-5223345	9.376658e-01	0.028
PI-3K cascade:FGFR4	R-HSA-5654720	9.389878e-01	0.027
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.389878e-01	0.027
Creatine metabolism	R-HSA-71288	9.389878e-01	0.027
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.389878e-01	0.027
Pregnenolone biosynthesis	R-HSA-196108	9.389878e-01	0.027
Opioid Signalling	R-HSA-111885	9.423736e-01	0.026
Post-translational protein modification	R-HSA-597592	9.429784e-01	0.025
Hyaluronan metabolism	R-HSA-2142845	9.431320e-01	0.025
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.431320e-01	0.025
Disorders of transmembrane transporters	R-HSA-5619115	9.439971e-01	0.025
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.443515e-01	0.025
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.450233e-01	0.025
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.454501e-01	0.024
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.454501e-01	0.024
Abacavir metabolism	R-HSA-2161541	9.454501e-01	0.024
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.454501e-01	0.024
Immune System	R-HSA-168256	9.464236e-01	0.024
Extracellular matrix organization	R-HSA-1474244	9.468990e-01	0.024
Downstream signaling of activated FGFR2	R-HSA-5654696	9.481400e-01	0.023
Downstream signaling of activated FGFR1	R-HSA-5654687	9.481400e-01	0.023
Gluconeogenesis	R-HSA-70263	9.489421e-01	0.023
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.512283e-01	0.022
SHC-mediated cascade:FGFR4	R-HSA-5654719	9.512283e-01	0.022
Ribavirin ADME	R-HSA-9755088	9.512283e-01	0.022
Molybdenum cofactor biosynthesis	R-HSA-947581	9.512283e-01	0.022
Glutathione synthesis and recycling	R-HSA-174403	9.512283e-01	0.022
Attachment and Entry	R-HSA-9694614	9.512283e-01	0.022
Mitochondrial protein import	R-HSA-1268020	9.526502e-01	0.021
FGFR2 mutant receptor activation	R-HSA-1839126	9.527255e-01	0.021
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.534575e-01	0.021
PI-3K cascade:FGFR1	R-HSA-5654689	9.563947e-01	0.019
Neurotoxicity of clostridium toxins	R-HSA-168799	9.563947e-01	0.019
Fructose metabolism	R-HSA-5652084	9.563947e-01	0.019
Ethanol oxidation	R-HSA-71384	9.563947e-01	0.019
Neuronal System	R-HSA-112316	9.567606e-01	0.019
Cleavage of the damaged purine	R-HSA-110331	9.569219e-01	0.019
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.569219e-01	0.019
Collagen chain trimerization	R-HSA-8948216	9.569219e-01	0.019
Regulation of insulin secretion	R-HSA-422356	9.591433e-01	0.018
Elastic fibre formation	R-HSA-1566948	9.607600e-01	0.017
Depurination	R-HSA-73927	9.607600e-01	0.017
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.610141e-01	0.017
ABC transporter disorders	R-HSA-5619084	9.628747e-01	0.016
ABC-family proteins mediated transport	R-HSA-382556	9.640213e-01	0.016
Neurotransmitter release cycle	R-HSA-112310	9.643416e-01	0.016
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.651443e-01	0.015
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.651443e-01	0.015
Complex III assembly	R-HSA-9865881	9.651443e-01	0.015
Interleukin-6 family signaling	R-HSA-6783589	9.651443e-01	0.015
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.654364e-01	0.015
Parasitic Infection Pathways	R-HSA-9824443	9.668412e-01	0.015
Leishmania infection	R-HSA-9658195	9.668412e-01	0.015
Protein localization	R-HSA-9609507	9.678243e-01	0.014
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.687490e-01	0.014
PI-3K cascade:FGFR2	R-HSA-5654695	9.688373e-01	0.014
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.688373e-01	0.014
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.688373e-01	0.014
Laminin interactions	R-HSA-3000157	9.688373e-01	0.014
Formation of the nephric duct	R-HSA-9830364	9.688373e-01	0.014
Regulated Necrosis	R-HSA-5218859	9.700638e-01	0.013
Amyloid fiber formation	R-HSA-977225	9.700774e-01	0.013
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.704026e-01	0.013
Maturation of spike protein	R-HSA-9694548	9.704026e-01	0.013
Formation of the cornified envelope	R-HSA-6809371	9.705578e-01	0.013
Signaling by Insulin receptor	R-HSA-74752	9.709195e-01	0.013
Paracetamol ADME	R-HSA-9753281	9.715054e-01	0.013
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.721391e-01	0.012
Linoleic acid (LA) metabolism	R-HSA-2046105	9.721391e-01	0.012
Sphingolipid catabolism	R-HSA-9845614	9.721391e-01	0.012
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.721391e-01	0.012
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.721391e-01	0.012
Ion channel transport	R-HSA-983712	9.729153e-01	0.012
Heme biosynthesis	R-HSA-189451	9.730755e-01	0.012
Translation of Structural Proteins	R-HSA-9683701	9.730755e-01	0.012
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.741354e-01	0.011
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.743895e-01	0.011
Collagen formation	R-HSA-1474290	9.746634e-01	0.011
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.750913e-01	0.011
Signaling by BMP	R-HSA-201451	9.750913e-01	0.011
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.750913e-01	0.011
RNA Polymerase I Promoter Opening	R-HSA-73728	9.750913e-01	0.011
Cristae formation	R-HSA-8949613	9.750913e-01	0.011
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.750913e-01	0.011
Insulin processing	R-HSA-264876	9.750913e-01	0.011
Maturation of hRSV A proteins	R-HSA-9828806	9.750913e-01	0.011
ECM proteoglycans	R-HSA-3000178	9.763255e-01	0.010
Insulin receptor recycling	R-HSA-77387	9.777308e-01	0.010
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.777308e-01	0.010
Pyroptosis	R-HSA-5620971	9.777308e-01	0.010
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.777391e-01	0.010
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.792720e-01	0.009
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.792720e-01	0.009
Peroxisomal protein import	R-HSA-9033241	9.797548e-01	0.009
Amino acid transport across the plasma membrane	R-HSA-352230	9.797548e-01	0.009
Amine ligand-binding receptors	R-HSA-375280	9.797673e-01	0.009
Ca2+ pathway	R-HSA-4086398	9.797917e-01	0.009
Diseases of carbohydrate metabolism	R-HSA-5663084	9.797917e-01	0.009
DARPP-32 events	R-HSA-180024	9.800908e-01	0.009
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.800908e-01	0.009
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.800908e-01	0.009
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.800908e-01	0.009
Metabolism of polyamines	R-HSA-351202	9.814290e-01	0.008
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.816158e-01	0.008
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.816158e-01	0.008
Neurotransmitter clearance	R-HSA-112311	9.822008e-01	0.008
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.822008e-01	0.008
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.829705e-01	0.007
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.832999e-01	0.007
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.840872e-01	0.007
Cargo concentration in the ER	R-HSA-5694530	9.840872e-01	0.007
Neddylation	R-HSA-8951664	9.841464e-01	0.007
Infectious disease	R-HSA-5663205	9.849706e-01	0.007
Extra-nuclear estrogen signaling	R-HSA-9009391	9.856042e-01	0.006
Ion transport by P-type ATPases	R-HSA-936837	9.868938e-01	0.006
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.872818e-01	0.006
Recycling of bile acids and salts	R-HSA-159418	9.872818e-01	0.006
Asparagine N-linked glycosylation	R-HSA-446203	9.881732e-01	0.005
Glucagon signaling in metabolic regulation	R-HSA-163359	9.886300e-01	0.005
Acyl chain remodelling of PC	R-HSA-1482788	9.886300e-01	0.005
Heme degradation	R-HSA-189483	9.886300e-01	0.005
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.886871e-01	0.005
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.890099e-01	0.005
The phototransduction cascade	R-HSA-2514856	9.897089e-01	0.004
Calnexin/calreticulin cycle	R-HSA-901042	9.898354e-01	0.004
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.898354e-01	0.004
RA biosynthesis pathway	R-HSA-5365859	9.898354e-01	0.004
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.898354e-01	0.004
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.898354e-01	0.004
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.898354e-01	0.004
NPAS4 regulates expression of target genes	R-HSA-9768919	9.898354e-01	0.004
SLC-mediated transport of amino acids	R-HSA-9958863	9.899406e-01	0.004
RNA Polymerase I Promoter Escape	R-HSA-73772	9.906651e-01	0.004
Platelet homeostasis	R-HSA-418346	9.907063e-01	0.004
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.907950e-01	0.004
Acyl chain remodelling of PE	R-HSA-1482839	9.909130e-01	0.004
Transferrin endocytosis and recycling	R-HSA-917977	9.909130e-01	0.004
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.909130e-01	0.004
Amino acids regulate mTORC1	R-HSA-9639288	9.915343e-01	0.004
Nucleotide biosynthesis	R-HSA-8956320	9.915343e-01	0.004
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.918764e-01	0.004
Triglyceride catabolism	R-HSA-163560	9.918764e-01	0.004
COPII-mediated vesicle transport	R-HSA-204005	9.922986e-01	0.003
Voltage gated Potassium channels	R-HSA-1296072	9.927378e-01	0.003
SLC-mediated transport of organic cations	R-HSA-549127	9.927378e-01	0.003
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.929584e-01	0.003
Metabolism of cofactors	R-HSA-8978934	9.929584e-01	0.003
Degradation of the extracellular matrix	R-HSA-1474228	9.929952e-01	0.003
G alpha (z) signalling events	R-HSA-418597	9.930419e-01	0.003
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.935078e-01	0.003
FCERI mediated NF-kB activation	R-HSA-2871837	9.935798e-01	0.003
FCERI mediated MAPK activation	R-HSA-2871796	9.940634e-01	0.003
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.941963e-01	0.003
RAS processing	R-HSA-9648002	9.941963e-01	0.003
Dectin-2 family	R-HSA-5621480	9.942855e-01	0.002
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.948118e-01	0.002
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.948118e-01	0.002
Innate Immune System	R-HSA-168249	9.949018e-01	0.002
Iron uptake and transport	R-HSA-917937	9.950912e-01	0.002
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.953620e-01	0.002
Aflatoxin activation and detoxification	R-HSA-5423646	9.953620e-01	0.002
Signaling by Retinoic Acid	R-HSA-5362517	9.957530e-01	0.002
Scavenging by Class A Receptors	R-HSA-3000480	9.958539e-01	0.002
Translation of Structural Proteins	R-HSA-9694635	9.959074e-01	0.002
Aquaporin-mediated transport	R-HSA-445717	9.961544e-01	0.002
Collagen degradation	R-HSA-1442490	9.961544e-01	0.002
Nucleotide salvage	R-HSA-8956321	9.961544e-01	0.002
SLC-mediated transport of organic anions	R-HSA-9955298	9.962644e-01	0.002
Activation of GABAB receptors	R-HSA-991365	9.962937e-01	0.002
GABA B receptor activation	R-HSA-977444	9.962937e-01	0.002
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.962937e-01	0.002
Phospholipid metabolism	R-HSA-1483257	9.963639e-01	0.002
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.964468e-01	0.002
Glycerophospholipid biosynthesis	R-HSA-1483206	9.966866e-01	0.001
Pyrimidine catabolism	R-HSA-73621	9.966868e-01	0.001
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.967388e-01	0.001
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.970383e-01	0.001
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.970383e-01	0.001
Fanconi Anemia Pathway	R-HSA-6783310	9.973525e-01	0.001
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.978845e-01	0.001
O-linked glycosylation of mucins	R-HSA-913709	9.980895e-01	0.001
GPER1 signaling	R-HSA-9634597	9.981089e-01	0.001
Metal ion SLC transporters	R-HSA-425410	9.981089e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.983096e-01	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.983096e-01	0.001
Azathioprine ADME	R-HSA-9748787	9.984890e-01	0.001
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.984890e-01	0.001
Metabolism of porphyrins	R-HSA-189445	9.985876e-01	0.001
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.986058e-01	0.001
Meiotic recombination	R-HSA-912446	9.986493e-01	0.001
Complex IV assembly	R-HSA-9864848	9.986493e-01	0.001
Cytosolic sulfonation of small molecules	R-HSA-156584	9.986493e-01	0.001
Branched-chain amino acid catabolism	R-HSA-70895	9.986493e-01	0.001
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.987232e-01	0.001
Purine catabolism	R-HSA-74259	9.987232e-01	0.001
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.987927e-01	0.001
ROS and RNS production in phagocytes	R-HSA-1222556	9.989571e-01	0.000
Cardiac conduction	R-HSA-5576891	9.990210e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.993052e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.993052e-01	0.000
Disease	R-HSA-1643685	9.994144e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.994496e-01	0.000
Triglyceride metabolism	R-HSA-8979227	9.994496e-01	0.000
GABA receptor activation	R-HSA-977443	9.995081e-01	0.000
Glutathione conjugation	R-HSA-156590	9.995081e-01	0.000
Endogenous sterols	R-HSA-211976	9.995603e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.996235e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.996487e-01	0.000
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.996740e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.996740e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.997758e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.997758e-01	0.000
Kidney development	R-HSA-9830369	9.997758e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.998678e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.998707e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.998907e-01	0.000
Metabolism of proteins	R-HSA-392499	9.999055e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999084e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999087e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999181e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999199e-01	0.000
Potassium Channels	R-HSA-1296071	9.999199e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999414e-01	0.000
Keratinization	R-HSA-6805567	9.999423e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999654e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999809e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999833e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999849e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999849e-01	0.000
Interferon alpha/beta signaling	R-HSA-909733	9.999920e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999935e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999943e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999950e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.999992e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999992e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999994e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999995e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999995e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999997e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999998e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999998e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999998e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999999e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999999e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999999e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999999e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999999e-01	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000