HRI

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O00264 S57 Sugiyama PGRMC1 HPR6.6 PGRMC LCIFLLYKIVRGDQPAAsGDsDDDEPPPLPRLKRRDFtPAE
O43852 S69 Sugiyama CALU HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60841 S190 Sugiyama EIF5B IF2 KIAA0741 NsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGP
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O60927 S73 Sugiyama PPP1R11 HCGV TCTE5 MGRRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRG
O60927 S74 Sugiyama PPP1R11 HCGV TCTE5 GRRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGH
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95394 S64 Sugiyama PGM3 AGM1 LLAVLRSKQTKSTIGVMVtAsHNPEEDNGVKLVDPLGEMLA
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S173 Sugiyama ANXA1 ANX1 LPC1 NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04406 S210 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187 S114 Sugiyama ALPP PLAP DRFPYVALSKTYNVDKHVPDsGAtATAYLCGVKGNFQTIGL
P05198 S49 GPS6|SIGNOR|ELM|EPSD|PSP EIF2S1 EIF2A EMGAYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNE
P05198 S52 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2S1 EIF2A AYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNECVV
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P09429 S35 Sugiyama HMGB1 HMG1 syAFFVQtCREEHKKKHPDAsVNFsEFsKKCsERWKtMsAK
P09923 S111 Sugiyama ALPI DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P10696 S111 Sugiyama ALPG ALPPL ALPPL2 DRFPYVALSKTYSVDKHVPDsGAtATAYLCGVKGNFQTIGL
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P23396 T220 Sugiyama RPS3 OK/SW-cl.26 PKKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPV
P23396 T221 Sugiyama RPS3 OK/SW-cl.26 KKPLPDHVsIVEPKDEILPttPIsEQKGGKPEPPAMPQPVP
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P27816 T521 Sugiyama MAP4 GLLKDMsPLsEtEMALGKDVtPPPEtEVVLIKNVCLPPEME
P27816 T526 Sugiyama MAP4 MsPLsEtEMALGKDVtPPPEtEVVLIKNVCLPPEMEVALTE
P29401 S332 Sugiyama TKT GDKIATRKAYGQALAKLGHAsDRIIALDGDtKNstFsEIFK
P29401 T342 Sugiyama TKT GQALAKLGHAsDRIIALDGDtKNstFsEIFKKEHPDRFIEC
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35579 S1154 Sugiyama MYH9 KRDLGEELEALKtELEDtLDstAAQQELRSKREQEVNILKK
P35579 S1713 Sugiyama MYH9 ERAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQ
P35579 S1714 Sugiyama MYH9 RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P35579 S1916 Sugiyama MYH9 LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P35579 T1151 Sugiyama MYH9 EKQKRDLGEELEALKtELEDtLDstAAQQELRSKREQEVNI
P35579 T1155 Sugiyama MYH9 RDLGEELEALKtELEDtLDstAAQQELRSKREQEVNILKKT
P42677 S11 Sugiyama RPS27 MPS1 __________MPLAKDLLHPsPEEEKRKHKKKRLVQsPNsy
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P60484 T382 Sugiyama PTEN MMAC1 TEP1 sTSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItK
P60484 T383 Sugiyama PTEN MMAC1 TEP1 TSVtPDVsDNEPDHyRYsDttDsDPENEPFDEDQHtQItKV
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62857 T38 Sugiyama RPS28 LGRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtL
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P67936 T241 Sugiyama TPM4 EEKLAQAKEENVGLHQtLDQtLNELNCI_____________
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q13769 S314 Sugiyama THOC5 C22orf19 KIAA0983 VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15293 S80 Sugiyama RCN1 RCN HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q16513 T958 Sugiyama PKN2 PRK2 PRKCL2 RGREDVSNFDDEFtsEAPILtPPREPRILsEEEQEMFRDFD
Q6PCE3 S175 Sugiyama PGM2L1 BM32A PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6PKG0 S627 Sugiyama LARP1 KIAA0731 LARP FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6PKG0 S631 Sugiyama LARP1 KIAA0731 LARP EEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPH
Q6PKG0 Y633 Sugiyama LARP1 KIAA0731 LARP MEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPHyM
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q92769 S422 Sugiyama HDAC2 PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q99676 T167 Sugiyama ZNF184 EGSLERQQANQQTLPKEIKVtEKTIPSWEKGPVNNEFGKSV
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQI3 S144 Sugiyama EIF2AK1 HRI KIAA1369 PRO1362 ITHLMRSAKERVRQDPCEDIsRIQKIRsREVALEAQTSRYL
Q9BQI3 S151 Sugiyama EIF2AK1 HRI KIAA1369 PRO1362 AKERVRQDPCEDIsRIQKIRsREVALEAQTSRYLNEFEELA
Q9BQI3 S253 Sugiyama EIF2AK1 HRI KIAA1369 PRO1362 WIEHVHVIQPRADRAAIELPsLEVLsDQEEDREQCGVKNDE
Q9BQI3 S258 Sugiyama EIF2AK1 HRI KIAA1369 PRO1362 HVIQPRADRAAIELPsLEVLsDQEEDREQCGVKNDEsssss
Q9BQI3 S409 Sugiyama EIF2AK1 HRI KIAA1369 PRO1362 LSLWDWIVERNKRGREyVDEsACPYVMANVATKIFQELVEG
Q9BQI3 Y405 Sugiyama EIF2AK1 HRI KIAA1369 PRO1362 QLCELSLWDWIVERNKRGREyVDEsACPYVMANVATKIFQE
Q9BRS2 T509 Sugiyama RIOK1 RIO1 QVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDPDI
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9NPQ8 T441 Sugiyama RIC8A AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NRX4 T119 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9UPR0 T584 Sugiyama PLCL2 KIAA1092 PLCE2 KILIKAKKLsSNCSGVEGDVtDEDEGAEMSQRMGKENMEQP
Q9UQ35 T856 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SsssPHPKVKsGtPPRQGsItsPQANEQsVtPQRRsCFEss
Q9Y266 T145 Sugiyama NUDC AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 9.500178e-13 12.022 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.746614e-11 10.241 0 0
Cell Cycle, Mitotic R-HSA-69278 2.319680e-10 9.635 0 0
Axon guidance R-HSA-422475 1.409022e-09 8.851 0 0
Nervous system development R-HSA-9675108 1.709107e-09 8.767 0 0
Mitotic Anaphase R-HSA-68882 7.361330e-08 7.133 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.174755e-08 7.088 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.165646e-07 6.933 0 0
Signaling by ALK in cancer R-HSA-9700206 1.165646e-07 6.933 0 0
M Phase R-HSA-68886 1.467380e-07 6.833 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.528904e-07 6.344 0 0
G2/M Transition R-HSA-69275 5.261848e-07 6.279 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.484288e-07 6.188 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.429069e-07 6.129 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.223505e-06 5.912 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.223505e-06 5.912 0 0
Separation of Sister Chromatids R-HSA-2467813 1.067929e-06 5.971 0 0
Mitotic Prometaphase R-HSA-68877 1.078682e-06 5.967 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.124070e-06 5.949 0 0
Signaling by ERBB2 R-HSA-1227986 1.244959e-06 5.905 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.040852e-06 5.983 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.809637e-06 5.742 0 0
SOS-mediated signalling R-HSA-112412 3.101671e-06 5.508 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.494768e-06 5.347 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.567661e-06 5.340 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.259159e-06 5.279 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.259159e-06 5.279 0 0
Interleukin-12 signaling R-HSA-9020591 5.083669e-06 5.294 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 7.150619e-06 5.146 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.150619e-06 5.146 0 0
MET activates RAS signaling R-HSA-8851805 7.150619e-06 5.146 0 0
Apoptotic execution phase R-HSA-75153 7.055404e-06 5.151 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.925063e-06 5.003 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.528494e-06 5.021 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.434284e-06 5.025 0 0
Signaling by KIT in disease R-HSA-9669938 9.925063e-06 5.003 0 0
Tie2 Signaling R-HSA-210993 1.348852e-05 4.870 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.348852e-05 4.870 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.524103e-05 4.817 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.779845e-05 4.750 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.668633e-05 4.778 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.590918e-05 4.798 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.689751e-05 4.772 0 0
Signaling by SCF-KIT R-HSA-1433557 1.765390e-05 4.753 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.026564e-05 4.693 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.572186e-05 4.590 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.579339e-05 4.588 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.663257e-05 4.575 0 0
Interleukin-12 family signaling R-HSA-447115 2.916564e-05 4.535 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.029671e-05 4.519 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.053049e-05 4.515 0 0
Signaling by MET R-HSA-6806834 3.343661e-05 4.476 0 0
MAPK family signaling cascades R-HSA-5683057 3.350576e-05 4.475 0 0
Aggrephagy R-HSA-9646399 3.613679e-05 4.442 0 0
Recycling pathway of L1 R-HSA-437239 3.799118e-05 4.420 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.939341e-05 4.405 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.101427e-05 4.387 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.630206e-05 4.334 0 0
Signal Transduction R-HSA-162582 4.808053e-05 4.318 0 0
Signaling by VEGF R-HSA-194138 5.580869e-05 4.253 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.240401e-05 4.205 0 0
Activation of RAS in B cells R-HSA-1169092 6.240401e-05 4.205 0 0
Signaling by LTK R-HSA-9842663 6.122592e-05 4.213 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.384128e-05 4.195 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.515323e-05 4.186 0 0
Signaling by Hippo R-HSA-2028269 6.691833e-05 4.174 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.026629e-05 4.095 0 0
Signaling by FGFR4 R-HSA-5654743 7.775691e-05 4.109 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.649227e-05 4.063 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.001440e-04 3.999 0 0
Downstream signal transduction R-HSA-186763 1.001440e-04 3.999 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.021530e-04 3.991 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.072298e-04 3.970 0 0
Signaling by FGFR3 R-HSA-5654741 1.108730e-04 3.955 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.210357e-04 3.917 0 0
Signaling by RAS mutants R-HSA-6802949 1.315420e-04 3.881 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.315420e-04 3.881 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.315420e-04 3.881 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.315420e-04 3.881 0 0
Erythropoietin activates RAS R-HSA-9027284 1.749405e-04 3.757 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.749405e-04 3.757 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.749405e-04 3.757 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.749405e-04 3.757 0 0
EPH-Ephrin signaling R-HSA-2682334 1.920302e-04 3.717 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.970543e-04 3.705 0 0
Gap junction trafficking and regulation R-HSA-157858 2.144713e-04 3.669 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.338254e-04 3.631 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.357060e-04 3.628 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.659827e-04 3.575 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.659827e-04 3.575 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.557324e-04 3.592 0 0
Signalling to ERKs R-HSA-187687 2.733946e-04 3.563 0 0
Post NMDA receptor activation events R-HSA-438064 2.924260e-04 3.534 0 0
Kinesins R-HSA-983189 2.983875e-04 3.525 0 0
Cellular responses to stress R-HSA-2262752 3.059577e-04 3.514 1 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.183709e-04 3.497 0 0
RET signaling R-HSA-8853659 3.282151e-04 3.484 0 0
Signaling by FGFR2 R-HSA-5654738 3.544860e-04 3.450 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.801772e-04 3.420 0 0
DAP12 signaling R-HSA-2424491 3.854307e-04 3.414 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.919143e-04 3.407 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.249736e-04 3.372 0 0
Semaphorin interactions R-HSA-373755 4.455151e-04 3.351 0 0
Cellular responses to stimuli R-HSA-8953897 4.553094e-04 3.342 1 0
GRB2 events in EGFR signaling R-HSA-179812 4.601624e-04 3.337 0 0
IGF1R signaling cascade R-HSA-2428924 5.065531e-04 3.295 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.473707e-04 3.262 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.745236e-04 3.241 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.745236e-04 3.241 0 0
Signaling by EGFR R-HSA-177929 5.933324e-04 3.227 0 0
Signaling by FGFR1 R-HSA-5654736 5.933324e-04 3.227 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.536998e-04 3.185 0 0
Gene expression (Transcription) R-HSA-74160 6.598480e-04 3.181 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.776984e-04 3.169 0 0
Integrin signaling R-HSA-354192 6.777095e-04 3.169 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.777095e-04 3.169 0 0
MAP2K and MAPK activation R-HSA-5674135 8.846687e-04 3.053 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.846687e-04 3.053 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.263621e-04 3.083 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.846687e-04 3.053 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.583128e-04 3.066 0 0
Regulation of KIT signaling R-HSA-1433559 8.443851e-04 3.073 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.443851e-04 3.073 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.938131e-04 3.049 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.013215e-04 3.045 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.581233e-04 3.019 0 0
Gap junction assembly R-HSA-190861 9.581233e-04 3.019 0 0
Muscle contraction R-HSA-397014 1.008639e-03 2.996 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 1.101652e-03 2.958 0 0
Signalling to RAS R-HSA-167044 1.101652e-03 2.958 0 0
Autophagy R-HSA-9612973 1.033269e-03 2.986 0 0
L1CAM interactions R-HSA-373760 1.074369e-03 2.969 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.111281e-03 2.954 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.220063e-03 2.914 0 0
Signal attenuation R-HSA-74749 1.220063e-03 2.914 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.220063e-03 2.914 0 0
Signaling by PDGF R-HSA-186797 1.265047e-03 2.898 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.363985e-03 2.865 0 0
Signaling by Erythropoietin R-HSA-9006335 1.405610e-03 2.852 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.405610e-03 2.852 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.405610e-03 2.852 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.363985e-03 2.865 0 0
FLT3 signaling in disease R-HSA-9682385 1.326026e-03 2.877 0 0
Signaling by NTRKs R-HSA-166520 1.318526e-03 2.880 0 0
Gap junction trafficking R-HSA-190828 1.369980e-03 2.863 0 0
Signaling by PTK6 R-HSA-8848021 1.422443e-03 2.847 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.422443e-03 2.847 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.438487e-03 2.842 0 0
Translation initiation complex formation R-HSA-72649 1.520551e-03 2.818 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.586703e-03 2.800 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.673003e-03 2.777 0 0
Macroautophagy R-HSA-1632852 1.683503e-03 2.774 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.720286e-03 2.764 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.887088e-03 2.724 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.834394e-03 2.737 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.799965e-03 2.745 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.940927e-03 2.712 0 0
MHC class II antigen presentation R-HSA-2132295 1.890268e-03 2.723 0 0
Developmental Biology R-HSA-1266738 1.948375e-03 2.710 0 0
Signaling by ALK R-HSA-201556 2.083213e-03 2.681 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.332982e-03 2.632 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 2.451007e-03 2.611 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.451007e-03 2.611 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.451333e-03 2.611 0 0
Selective autophagy R-HSA-9663891 2.547334e-03 2.594 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.722567e-03 2.565 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.755625e-03 2.560 0 0
FLT3 Signaling R-HSA-9607240 2.755625e-03 2.560 0 0
Signaling by FGFR R-HSA-190236 2.844075e-03 2.546 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.849225e-03 2.545 0 0
RNA Polymerase II Transcription R-HSA-73857 2.849454e-03 2.545 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.980198e-03 2.526 0 0
Striated Muscle Contraction R-HSA-390522 3.167933e-03 2.499 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.150702e-03 2.502 0 0
Apoptosis R-HSA-109581 3.369417e-03 2.472 0 0
Cell Cycle Checkpoints R-HSA-69620 3.272575e-03 2.485 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.481896e-03 2.458 0 0
Regulation of signaling by CBL R-HSA-912631 3.523398e-03 2.453 0 0
RAF activation R-HSA-5673000 3.667932e-03 2.436 0 0
Protein folding R-HSA-391251 3.944943e-03 2.404 0 0
ESR-mediated signaling R-HSA-8939211 4.047917e-03 2.393 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.077994e-03 2.390 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.107087e-03 2.386 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.107087e-03 2.386 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.226874e-03 2.374 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.226874e-03 2.374 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.608486e-03 2.336 0 0
DAP12 interactions R-HSA-2172127 4.608486e-03 2.336 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.610759e-03 2.336 0 0
Insulin receptor signalling cascade R-HSA-74751 4.661958e-03 2.331 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.900224e-03 2.310 0 0
Centrosome maturation R-HSA-380287 4.918674e-03 2.308 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.196070e-03 2.284 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.676336e-03 2.246 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.957529e-03 2.225 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.000520e-03 2.222 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.000520e-03 2.222 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.091200e-03 2.215 0 0
p38MAPK events R-HSA-171007 6.091200e-03 2.215 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.091200e-03 2.215 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.481440e-03 2.261 0 0
Generic Transcription Pathway R-HSA-212436 6.117801e-03 2.213 0 0
ALK mutants bind TKIs R-HSA-9700645 6.176224e-03 2.209 0 0
MET promotes cell motility R-HSA-8875878 6.301905e-03 2.201 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.543928e-03 2.184 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.687335e-03 2.175 0 0
Notch-HLH transcription pathway R-HSA-350054 7.295612e-03 2.137 0 0
Co-stimulation by CD28 R-HSA-389356 7.311139e-03 2.136 0 0
PKR-mediated signaling R-HSA-9833482 7.631997e-03 2.117 0 0
Metabolism of RNA R-HSA-8953854 7.878304e-03 2.104 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 8.122245e-03 2.090 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.122245e-03 2.090 0 0
PI3K/AKT activation R-HSA-198203 8.122245e-03 2.090 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.221453e-03 2.085 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.336214e-03 2.079 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 8.867354e-03 2.052 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 8.867354e-03 2.052 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.547854e-03 2.020 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.978210e-03 2.047 0 0
Neurodegenerative Diseases R-HSA-8863678 1.000519e-02 2.000 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.000519e-02 2.000 0 0
Cellular Senescence R-HSA-2559583 9.895353e-03 2.005 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.585331e-03 2.018 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.000519e-02 2.000 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.573095e-03 2.019 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.128538e-03 2.040 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.978210e-03 2.047 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.051182e-02 1.978 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.098139e-02 1.959 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.108446e-02 1.955 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.150481e-02 1.939 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.150481e-02 1.939 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.157405e-02 1.937 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.157405e-02 1.937 0 0
Signaling by ERBB4 R-HSA-1236394 1.157405e-02 1.937 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.222178e-02 1.913 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.257945e-02 1.900 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.267223e-02 1.897 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.267223e-02 1.897 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.267223e-02 1.897 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.267223e-02 1.897 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.307551e-02 1.884 0 0
Ephrin signaling R-HSA-3928664 1.307551e-02 1.884 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.307551e-02 1.884 0 0
Signaling by Interleukins R-HSA-449147 1.362005e-02 1.866 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.367412e-02 1.864 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.378115e-02 1.861 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.419706e-02 1.848 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.419706e-02 1.848 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.419706e-02 1.848 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.419706e-02 1.848 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.464261e-02 1.834 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.476817e-02 1.831 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.530675e-02 1.815 0 0
Signaling by FGFR3 in disease R-HSA-5655332 1.530675e-02 1.815 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.623197e-02 1.790 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.727647e-02 1.763 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.975951e-02 1.704 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.976493e-02 1.704 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.803773e-02 1.744 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.786425e-02 1.748 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.979895e-02 1.703 0 0
Signaling by LTK in cancer R-HSA-9842640 1.727647e-02 1.763 0 0
IRS-mediated signalling R-HSA-112399 1.765354e-02 1.753 0 0
Programmed Cell Death R-HSA-5357801 1.847431e-02 1.733 0 0
Interferon Signaling R-HSA-913531 2.011950e-02 1.696 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.025781e-02 1.693 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.123336e-02 1.673 0 0
Signaling by Insulin receptor R-HSA-74752 2.160087e-02 1.666 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.269518e-02 1.644 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.269518e-02 1.644 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.269518e-02 1.644 0 0
Degradation of CDH1 R-HSA-9766229 2.278752e-02 1.642 0 0
Signal regulatory protein family interactions R-HSA-391160 2.372506e-02 1.625 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.410536e-02 1.618 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.410536e-02 1.618 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 2.410536e-02 1.618 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.427457e-02 1.615 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 2.427457e-02 1.615 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.427457e-02 1.615 0 0
Diseases of cellular response to stress R-HSA-9675132 2.427457e-02 1.615 0 0
Diseases of Cellular Senescence R-HSA-9630747 2.427457e-02 1.615 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.427457e-02 1.615 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.427457e-02 1.615 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.427457e-02 1.615 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.427457e-02 1.615 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.427457e-02 1.615 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.427457e-02 1.615 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.427457e-02 1.615 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.427457e-02 1.615 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.427457e-02 1.615 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.427457e-02 1.615 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.433615e-02 1.614 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.445405e-02 1.612 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.457713e-02 1.609 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.508089e-02 1.601 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.570940e-02 1.590 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.813949e-02 1.551 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.757712e-02 1.559 0 0
Meiotic synapsis R-HSA-1221632 3.209051e-02 1.494 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.794582e-02 1.554 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.794582e-02 1.554 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.784351e-02 1.555 0 0
Ribosome-associated quality control R-HSA-9948299 2.646663e-02 1.577 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.588791e-02 1.587 0 0
DCC mediated attractive signaling R-HSA-418885 2.813949e-02 1.551 0 0
Homology Directed Repair R-HSA-5693538 2.989391e-02 1.524 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.947326e-02 1.531 0 0
Meiosis R-HSA-1500620 2.615782e-02 1.582 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.680186e-02 1.572 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.650769e-02 1.577 0 0
Co-stimulation by ICOS R-HSA-9927354 2.893212e-02 1.539 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.231860e-02 1.491 0 0
Smooth Muscle Contraction R-HSA-445355 3.209051e-02 1.494 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.116224e-02 1.506 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.041830e-02 1.517 0 0
Signaling by FGFR in disease R-HSA-1226099 2.761688e-02 1.559 0 0
Cilium Assembly R-HSA-5617833 2.886515e-02 1.540 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 2.757712e-02 1.559 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.152985e-02 1.501 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.127948e-02 1.505 0 0
Mitotic Prophase R-HSA-68875 3.323002e-02 1.478 0 0
Peptide chain elongation R-HSA-156902 3.383493e-02 1.471 0 0
DNA Repair R-HSA-73894 3.519199e-02 1.454 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.532082e-02 1.452 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.598135e-02 1.444 0 0
Classical Kir channels R-HSA-1296053 3.648668e-02 1.438 0 0
Hedgehog 'off' state R-HSA-5610787 3.736858e-02 1.427 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.819578e-02 1.418 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.819578e-02 1.418 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.821734e-02 1.418 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.834363e-02 1.416 0 0
Cellular response to starvation R-HSA-9711097 3.852749e-02 1.414 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.856611e-02 1.414 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.982842e-02 1.400 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 3.982842e-02 1.400 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.055069e-02 1.392 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.175556e-02 1.379 0 0
Regulation of TP53 Activity R-HSA-5633007 4.200169e-02 1.377 0 0
Oncogene Induced Senescence R-HSA-2559585 4.206232e-02 1.376 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.206232e-02 1.376 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.244553e-02 1.372 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.307954e-02 1.366 0 0
Regulation of CDH1 Function R-HSA-9764561 4.369912e-02 1.360 0 0
Regulation of CDH11 function R-HSA-9762292 4.382873e-02 1.358 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.414052e-02 1.355 0 0
S Phase R-HSA-69242 4.436450e-02 1.353 0 0
Diseases of DNA repair R-HSA-9675135 4.551222e-02 1.342 0 0
RUNX2 regulates bone development R-HSA-8941326 4.616651e-02 1.336 0 0
Signaling by ROBO receptors R-HSA-376176 4.819562e-02 1.317 0 0
G2/M Checkpoints R-HSA-69481 4.928358e-02 1.307 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.957206e-02 1.305 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.957206e-02 1.305 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.957206e-02 1.305 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.040092e-02 1.298 0 0
Polo-like kinase mediated events R-HSA-156711 5.040092e-02 1.298 0 0
GAB1 signalosome R-HSA-180292 5.040092e-02 1.298 0 0
Apoptotic factor-mediated response R-HSA-111471 5.040092e-02 1.298 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.042294e-02 1.297 0 0
Regulation of gap junction activity R-HSA-191650 5.055309e-02 1.296 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.055309e-02 1.296 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.055309e-02 1.296 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.055309e-02 1.296 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.055309e-02 1.296 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.055309e-02 1.296 0 0
Cell-Cell communication R-HSA-1500931 5.139871e-02 1.289 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.245323e-02 1.280 0 0
PECAM1 interactions R-HSA-210990 5.245323e-02 1.280 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.323719e-02 1.274 0 0
Intraflagellar transport R-HSA-5620924 5.323719e-02 1.274 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.370014e-02 1.270 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.402207e-02 1.267 0 0
HIV elongation arrest and recovery R-HSA-167287 5.492424e-02 1.260 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.492424e-02 1.260 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.492424e-02 1.260 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.492424e-02 1.260 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.509735e-02 1.259 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.702751e-02 1.244 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.712190e-02 1.243 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.712190e-02 1.243 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 5.787571e-02 1.238 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 5.787571e-02 1.238 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.948032e-02 1.226 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.967625e-02 1.224 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.990529e-02 1.223 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.992717e-02 1.222 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.059724e-02 1.218 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.173623e-02 1.209 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.182810e-02 1.209 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.182810e-02 1.209 0 0
IRS activation R-HSA-74713 6.621870e-02 1.179 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.621870e-02 1.179 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.269959e-02 1.082 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.500098e-02 1.187 0 0
HIV Transcription Elongation R-HSA-167169 6.500098e-02 1.187 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.500098e-02 1.187 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.952618e-02 1.099 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.952618e-02 1.099 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.952618e-02 1.099 0 0
Repression of WNT target genes R-HSA-4641265 7.192194e-02 1.143 0 0
Frs2-mediated activation R-HSA-170968 8.269959e-02 1.082 0 0
Cellular response to heat stress R-HSA-3371556 6.532540e-02 1.185 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.621870e-02 1.179 0 0
Signaling by NODAL R-HSA-1181150 6.429821e-02 1.192 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.836969e-02 1.165 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.108464e-02 1.091 0 0
Host Interactions of HIV factors R-HSA-162909 7.447870e-02 1.128 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.272691e-02 1.138 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 8.325170e-02 1.080 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 8.325170e-02 1.080 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 8.325170e-02 1.080 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 8.325170e-02 1.080 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 8.325170e-02 1.080 0 0
DNA Double Strand Break Response R-HSA-5693606 8.375627e-02 1.077 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.474183e-02 1.072 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.524324e-02 1.069 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.632030e-02 1.064 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.646221e-02 1.063 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.646221e-02 1.063 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.646221e-02 1.063 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.772667e-02 1.057 0 0
Transcription of the HIV genome R-HSA-167172 8.865826e-02 1.052 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.931996e-02 1.049 0 0
Influenza Infection R-HSA-168255 8.968092e-02 1.047 0 0
Ion homeostasis R-HSA-5578775 9.193237e-02 1.037 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 9.370383e-02 1.028 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.398746e-02 1.027 0 0
G1 Phase R-HSA-69236 9.400810e-02 1.027 0 0
Cyclin D associated events in G1 R-HSA-69231 9.400810e-02 1.027 0 0
Netrin-1 signaling R-HSA-373752 9.400810e-02 1.027 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.400810e-02 1.027 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.412298e-02 1.026 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.738026e-02 1.012 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.738026e-02 1.012 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.738026e-02 1.012 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.002174e-01 0.999 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.012451e-01 0.995 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.014417e-01 0.994 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 1.014417e-01 0.994 0 0
NADPH regeneration R-HSA-389542 1.014417e-01 0.994 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.014417e-01 0.994 0 0
Nef and signal transduction R-HSA-164944 1.014417e-01 0.994 0 0
Signaling by Activin R-HSA-1502540 1.061518e-01 0.974 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.061518e-01 0.974 0 0
Adipogenesis R-HSA-9843745 1.067125e-01 0.972 0 0
Eukaryotic Translation Termination R-HSA-72764 1.069488e-01 0.971 0 0
HIV Infection R-HSA-162906 1.083191e-01 0.965 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.124051e-01 0.949 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.124051e-01 0.949 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.124051e-01 0.949 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.124051e-01 0.949 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.124051e-01 0.949 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.124051e-01 0.949 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.124051e-01 0.949 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 1.124051e-01 0.949 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.124051e-01 0.949 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.124051e-01 0.949 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.124051e-01 0.949 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.124051e-01 0.949 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.124051e-01 0.949 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 1.124051e-01 0.949 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.637815e-01 0.786 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.637815e-01 0.786 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.637815e-01 0.786 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 1.637815e-01 0.786 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 1.637815e-01 0.786 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.637815e-01 0.786 0 0
XAV939 stabilizes AXIN R-HSA-5545619 1.637815e-01 0.786 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.637815e-01 0.786 0 0
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-5619099 1.637815e-01 0.786 0 0
Recycling of eIF2:GDP R-HSA-72731 1.205981e-01 0.919 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.205981e-01 0.919 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.405482e-01 0.852 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 1.405482e-01 0.852 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.405482e-01 0.852 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.405482e-01 0.852 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.405482e-01 0.852 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.611364e-01 0.793 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.611364e-01 0.793 0 0
Phosphorylation of the APC/C R-HSA-176412 1.187443e-01 0.925 0 0
Phase 4 - resting membrane potential R-HSA-5576886 1.187443e-01 0.925 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.187443e-01 0.925 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.594723e-01 0.797 0 0
Telomere Extension By Telomerase R-HSA-171319 1.475841e-01 0.831 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.255956e-01 0.901 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.523565e-01 0.817 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.523565e-01 0.817 0 0
mRNA 3'-end processing R-HSA-72187 1.523626e-01 0.817 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.605930e-01 0.794 0 0
Viral mRNA Translation R-HSA-192823 1.487111e-01 0.828 0 0
mRNA Splicing R-HSA-72172 1.284953e-01 0.891 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.421136e-01 0.847 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.264338e-01 0.898 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.187443e-01 0.925 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.205981e-01 0.919 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 1.611364e-01 0.793 0 0
RAS processing R-HSA-9648002 1.431842e-01 0.844 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.405482e-01 0.852 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.318575e-01 0.880 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.368428e-01 0.864 0 0
HCMV Early Events R-HSA-9609690 1.501914e-01 0.823 0 0
FOXO-mediated transcription R-HSA-9614085 1.268945e-01 0.897 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.288619e-01 0.890 0 0
Prolonged ERK activation events R-HSA-169893 1.187443e-01 0.925 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.611364e-01 0.793 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.098861e-01 0.959 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.159249e-01 0.936 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.159249e-01 0.936 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.159249e-01 0.936 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.159249e-01 0.936 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.611364e-01 0.793 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.617669e-01 0.791 0 0
ARMS-mediated activation R-HSA-170984 1.611364e-01 0.793 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.611364e-01 0.793 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.523565e-01 0.817 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.104379e-01 0.957 0 0
Adaptive Immune System R-HSA-1280218 1.254463e-01 0.902 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.586387e-01 0.800 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.155918e-01 0.937 0 0
rRNA processing R-HSA-72312 1.243226e-01 0.905 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.611364e-01 0.793 0 0
Pyroptosis R-HSA-5620971 1.475841e-01 0.831 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.274696e-01 0.895 0 0
PTEN Regulation R-HSA-6807070 1.460924e-01 0.835 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.207480e-01 0.918 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.597716e-01 0.797 0 0
SLC-mediated bile acid transport R-HSA-9958517 1.405482e-01 0.852 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.159249e-01 0.936 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.523626e-01 0.817 0 0
GPVI-mediated activation cascade R-HSA-114604 1.171989e-01 0.931 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.227917e-01 0.911 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.290325e-01 0.889 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.611364e-01 0.793 0 0
Selenocysteine synthesis R-HSA-2408557 1.375743e-01 0.861 0 0
NTRK3 as a dependence receptor R-HSA-9603505 1.637815e-01 0.786 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.205981e-01 0.919 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.368428e-01 0.864 0 0
Interleukin-2 family signaling R-HSA-451927 1.523565e-01 0.817 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.431842e-01 0.844 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.475841e-01 0.831 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.205981e-01 0.919 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 1.611364e-01 0.793 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.530244e-01 0.815 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.586387e-01 0.800 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.611364e-01 0.793 1 1
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.245386e-01 0.905 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.460924e-01 0.835 0 0
Interleukin-7 signaling R-HSA-1266695 1.163755e-01 0.934 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.657955e-01 0.780 0 0
HIV Life Cycle R-HSA-162587 1.679426e-01 0.775 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.695372e-01 0.771 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.699870e-01 0.770 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.699870e-01 0.770 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.699870e-01 0.770 0 0
Intra-Golgi traffic R-HSA-6811438 1.714045e-01 0.766 0 0
Cardiac conduction R-HSA-5576891 1.737326e-01 0.760 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.738871e-01 0.760 0 0
Rap1 signalling R-HSA-392517 1.738871e-01 0.760 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 1.738871e-01 0.760 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.784600e-01 0.748 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.803796e-01 0.744 0 0
Membrane Trafficking R-HSA-199991 1.805258e-01 0.743 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.812579e-01 0.742 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.812579e-01 0.742 0 0
EGFR downregulation R-HSA-182971 1.816091e-01 0.741 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.816091e-01 0.741 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.816091e-01 0.741 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.822222e-01 0.739 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.822222e-01 0.739 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.822222e-01 0.739 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.822222e-01 0.739 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.822222e-01 0.739 0 0
Signaling by Leptin R-HSA-2586552 1.822222e-01 0.739 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.882023e-01 0.725 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.882023e-01 0.725 0 0
Chromatin organization R-HSA-4839726 1.885677e-01 0.725 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.886495e-01 0.724 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.886495e-01 0.724 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.886495e-01 0.724 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.886495e-01 0.724 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.886495e-01 0.724 0 0
Formation of definitive endoderm R-HSA-9823730 1.886495e-01 0.724 0 0
Nephrin family interactions R-HSA-373753 1.886495e-01 0.724 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.886495e-01 0.724 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 2.121870e-01 0.673 0 0
Potassium transport channels R-HSA-1296067 2.121870e-01 0.673 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 2.121870e-01 0.673 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 2.121870e-01 0.673 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.577932e-01 0.589 0 0
Axonal growth stimulation R-HSA-209563 2.577932e-01 0.589 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 2.577932e-01 0.589 0 0
Defective ABCA1 causes TGD R-HSA-5682113 2.577932e-01 0.589 0 0
MET activates PTPN11 R-HSA-8865999 2.577932e-01 0.589 0 0
HCN channels R-HSA-1296061 3.007619e-01 0.522 0 0
Nucleotide catabolism defects R-HSA-9735786 3.007619e-01 0.522 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 3.007619e-01 0.522 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 3.007619e-01 0.522 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 3.007619e-01 0.522 0 0
Signaling by MAP2K mutants R-HSA-9652169 3.007619e-01 0.522 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 3.412455e-01 0.467 0 0
NTRK2 activates RAC1 R-HSA-9032759 3.412455e-01 0.467 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.412455e-01 0.467 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.412455e-01 0.467 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.412455e-01 0.467 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.253938e-01 0.647 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.253938e-01 0.647 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.253938e-01 0.647 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.472647e-01 0.607 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.472647e-01 0.607 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.472647e-01 0.607 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.472647e-01 0.607 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.472647e-01 0.607 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.472647e-01 0.607 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.911220e-01 0.536 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.911220e-01 0.536 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 2.346078e-01 0.630 0 0
FGFR2 alternative splicing R-HSA-6803529 2.346078e-01 0.630 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.129561e-01 0.505 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.129561e-01 0.505 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.129561e-01 0.505 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.503517e-01 0.601 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.503517e-01 0.601 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.055936e-01 0.687 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.055936e-01 0.687 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.179151e-01 0.662 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.179151e-01 0.662 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.822521e-01 0.549 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.431150e-01 0.614 0 0
MET activates PTK2 signaling R-HSA-8874081 2.983391e-01 0.525 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.044075e-01 0.690 0 0
Degradation of AXIN R-HSA-4641257 2.689232e-01 0.570 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.689232e-01 0.570 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.144738e-01 0.502 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.773411e-01 0.423 0 0
snRNP Assembly R-HSA-191859 2.136495e-01 0.670 0 0
Metabolism of non-coding RNA R-HSA-194441 2.136495e-01 0.670 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.306257e-01 0.481 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.306257e-01 0.481 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.951828e-01 0.530 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.951828e-01 0.530 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.084346e-01 0.511 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.084346e-01 0.511 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.350916e-01 0.475 0 0
HIV Transcription Initiation R-HSA-167161 3.350916e-01 0.475 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.350916e-01 0.475 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.818177e-01 0.550 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.618389e-01 0.441 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.350863e-01 0.475 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.749176e-01 0.426 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.936236e-01 0.713 0 0
Nucleotide Excision Repair R-HSA-5696398 2.671810e-01 0.573 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.089251e-01 0.680 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.007028e-01 0.522 0 0
Chromosome Maintenance R-HSA-73886 2.888709e-01 0.539 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.692010e-01 0.570 0 0
mRNA Capping R-HSA-72086 3.467660e-01 0.460 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.113282e-01 0.507 0 0
Extension of Telomeres R-HSA-180786 3.700443e-01 0.432 0 0
Neddylation R-HSA-8951664 3.669281e-01 0.435 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.350863e-01 0.475 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.107182e-01 0.676 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.217433e-01 0.492 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.926906e-01 0.534 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.951659e-01 0.530 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.084346e-01 0.511 0 0
Attenuation phase R-HSA-3371568 3.084346e-01 0.511 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.107182e-01 0.676 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.333472e-01 0.632 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.331203e-01 0.477 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.331203e-01 0.477 0 0
DNA Damage Bypass R-HSA-73893 2.552713e-01 0.593 0 0
Formation of axial mesoderm R-HSA-9796292 2.692010e-01 0.570 0 0
Integration of provirus R-HSA-162592 2.253938e-01 0.647 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.472647e-01 0.607 0 0
HSF1 activation R-HSA-3371511 2.559530e-01 0.592 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.951828e-01 0.530 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.179151e-01 0.662 0 0
Signaling by NOTCH3 R-HSA-9012852 3.234876e-01 0.490 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.007619e-01 0.522 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 3.412455e-01 0.467 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.472647e-01 0.607 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.692010e-01 0.570 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.055936e-01 0.687 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.561179e-01 0.448 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.773411e-01 0.423 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.503517e-01 0.601 1 1
TRAF3-dependent IRF activation pathway R-HSA-918233 3.561179e-01 0.448 0 0
Translation R-HSA-72766 2.926399e-01 0.534 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.129561e-01 0.505 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.559530e-01 0.592 0 0
Cellular response to chemical stress R-HSA-9711123 2.762237e-01 0.559 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.132476e-01 0.504 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.036791e-01 0.691 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.692010e-01 0.570 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 3.129561e-01 0.505 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.346400e-01 0.475 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.773411e-01 0.423 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.217433e-01 0.492 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.005619e-01 0.698 0 0
Vasopressin-like receptors R-HSA-388479 3.007619e-01 0.522 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.911220e-01 0.536 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 3.773411e-01 0.423 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.962810e-01 0.707 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.628674e-01 0.440 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.004393e-01 0.522 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.055936e-01 0.687 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.773411e-01 0.423 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.084346e-01 0.511 0 0
Potassium Channels R-HSA-1296071 3.093272e-01 0.510 0 0
Signaling by NOTCH4 R-HSA-9013694 3.644379e-01 0.438 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.822521e-01 0.549 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 2.121870e-01 0.673 0 0
MET interacts with TNS proteins R-HSA-8875513 2.577932e-01 0.589 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.007619e-01 0.522 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.412455e-01 0.467 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 2.472647e-01 0.607 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.692010e-01 0.570 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 2.911220e-01 0.536 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 2.911220e-01 0.536 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 2.911220e-01 0.536 0 0
mTORC1-mediated signalling R-HSA-166208 2.346078e-01 0.630 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.561179e-01 0.448 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.325481e-01 0.633 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.350916e-01 0.475 0 0
Downstream TCR signaling R-HSA-202424 2.421832e-01 0.616 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.367169e-01 0.626 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.539731e-01 0.451 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.796006e-01 0.553 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 3.484622e-01 0.458 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.435313e-01 0.464 0 0
PERK regulates gene expression R-HSA-381042 2.431150e-01 0.614 0 0
Heme signaling R-HSA-9707616 2.421878e-01 0.616 0 0
Diseases of programmed cell death R-HSA-9645723 2.262063e-01 0.645 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.147415e-01 0.668 0 0
Formation of the anterior neural plate R-HSA-9823739 3.129561e-01 0.505 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.129561e-01 0.505 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.179151e-01 0.662 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 3.561179e-01 0.448 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.055936e-01 0.687 0 0
Signaling by NOTCH1 R-HSA-1980143 2.385716e-01 0.622 0 0
TCR signaling R-HSA-202403 1.975331e-01 0.704 0 0
Neuronal System R-HSA-112316 2.586582e-01 0.587 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.325481e-01 0.633 0 0
Regulation of BACH1 activity R-HSA-9708530 3.346400e-01 0.475 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.079804e-01 0.511 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.435313e-01 0.464 0 0
Signaling by Hedgehog R-HSA-5358351 2.200598e-01 0.657 0 0
Platelet degranulation R-HSA-114608 3.422426e-01 0.466 0 0
Interleukin-15 signaling R-HSA-8983432 2.472647e-01 0.607 0 0
HDMs demethylate histones R-HSA-3214842 2.822521e-01 0.549 0 0
Cell junction organization R-HSA-446728 2.492002e-01 0.603 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.822521e-01 0.549 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.822521e-01 0.549 0 0
G alpha (q) signalling events R-HSA-416476 2.565948e-01 0.591 0 0
Transmission across Chemical Synapses R-HSA-112315 2.415013e-01 0.617 0 0
Chromatin modifying enzymes R-HSA-3247509 2.620497e-01 0.582 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.577932e-01 0.589 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.577932e-01 0.589 0 0
NADE modulates death signalling R-HSA-205025 3.007619e-01 0.522 0 0
Sensory perception of sour taste R-HSA-9729555 3.007619e-01 0.522 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 2.036791e-01 0.691 0 0
Inositol transporters R-HSA-429593 3.412455e-01 0.467 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 3.412455e-01 0.467 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.346078e-01 0.630 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.561179e-01 0.448 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.743178e-01 0.562 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.346078e-01 0.630 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.346078e-01 0.630 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.773411e-01 0.423 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.583756e-01 0.446 0 0
Ub-specific processing proteases R-HSA-5689880 2.606754e-01 0.584 0 0
Ca2+ pathway R-HSA-4086398 3.539731e-01 0.451 0 0
Suppression of apoptosis R-HSA-9635465 2.036791e-01 0.691 0 0
Malate-aspartate shuttle R-HSA-9856872 2.911220e-01 0.536 0 0
Nuclear import of Rev protein R-HSA-180746 2.304291e-01 0.637 0 0
NRAGE signals death through JNK R-HSA-193648 3.350863e-01 0.475 0 0
Immune System R-HSA-168256 3.637560e-01 0.439 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.517953e-01 0.599 0 0
Reproduction R-HSA-1474165 2.588662e-01 0.587 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.435313e-01 0.464 0 0
Syndecan interactions R-HSA-3000170 2.503517e-01 0.601 0 0
Stabilization of p53 R-HSA-69541 2.951828e-01 0.530 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.473673e-01 0.607 0 0
Hemostasis R-HSA-109582 2.482089e-01 0.605 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.577932e-01 0.589 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 3.007619e-01 0.522 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.007619e-01 0.522 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 3.412455e-01 0.467 0 0
Co-inhibition by BTLA R-HSA-9927353 3.412455e-01 0.467 0 0
Reelin signalling pathway R-HSA-8866376 3.412455e-01 0.467 0 0
Activation of RAC1 R-HSA-428540 2.253938e-01 0.647 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.692010e-01 0.570 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.346400e-01 0.475 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.951828e-01 0.530 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.084346e-01 0.511 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.519433e-01 0.599 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.217433e-01 0.492 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.204192e-01 0.657 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.350863e-01 0.475 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 3.749176e-01 0.426 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.513539e-01 0.600 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.393676e-01 0.469 0 0
PI Metabolism R-HSA-1483255 2.367169e-01 0.626 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 2.230325e-01 0.652 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.346078e-01 0.630 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.079804e-01 0.511 0 0
Formation of the nephric duct R-HSA-9830364 2.822521e-01 0.549 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 3.412455e-01 0.467 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.253938e-01 0.647 0 0
Synthesis of PG R-HSA-1483148 3.561179e-01 0.448 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.773411e-01 0.423 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.820062e-01 0.550 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.519433e-01 0.599 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.253938e-01 0.647 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.503517e-01 0.601 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.951828e-01 0.530 0 0
PI3K Cascade R-HSA-109704 2.664169e-01 0.574 0 0
ChREBP activates metabolic gene expression R-HSA-163765 2.036791e-01 0.691 0 0
P2Y receptors R-HSA-417957 2.911220e-01 0.536 0 0
Selenoamino acid metabolism R-HSA-2408522 2.039238e-01 0.691 0 0
TRP channels R-HSA-3295583 2.983391e-01 0.525 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.953147e-01 0.709 0 0
OAS antiviral response R-HSA-8983711 2.472647e-01 0.607 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.890131e-01 0.539 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.817611e-01 0.550 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 3.412455e-01 0.467 0 0
Platelet calcium homeostasis R-HSA-418360 3.467660e-01 0.460 0 0
Interferon alpha/beta signaling R-HSA-909733 3.641635e-01 0.439 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.304291e-01 0.637 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.692010e-01 0.570 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.726670e-01 0.564 0 0
Growth hormone receptor signaling R-HSA-982772 2.503517e-01 0.601 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.789045e-01 0.421 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.789045e-01 0.421 0 0
Plus-strand DNA synthesis R-HSA-164525 3.793874e-01 0.421 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.793874e-01 0.421 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.793874e-01 0.421 0 0
Signaling by MAPK mutants R-HSA-9652817 3.793874e-01 0.421 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.793874e-01 0.421 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.793874e-01 0.421 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.793874e-01 0.421 0 0
Formation of the Editosome R-HSA-75094 3.793874e-01 0.421 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.793874e-01 0.421 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.793874e-01 0.421 0 0
Phosphorylation of Emi1 R-HSA-176417 3.793874e-01 0.421 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.793874e-01 0.421 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.793874e-01 0.421 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 3.793874e-01 0.421 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.793874e-01 0.421 0 0
VEGF ligand-receptor interactions R-HSA-194313 3.793874e-01 0.421 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.793874e-01 0.421 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.797428e-01 0.421 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.885478e-01 0.411 0 0
Nucleosome assembly R-HSA-774815 3.885478e-01 0.411 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.885478e-01 0.411 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.885478e-01 0.411 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.885478e-01 0.411 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.885478e-01 0.411 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.885478e-01 0.411 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.885478e-01 0.411 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.889477e-01 0.410 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.933765e-01 0.405 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.933765e-01 0.405 0 0
G0 and Early G1 R-HSA-1538133 3.948536e-01 0.404 0 0
Signaling by WNT in cancer R-HSA-4791275 3.948536e-01 0.404 0 0
IRE1alpha activates chaperones R-HSA-381070 3.971188e-01 0.401 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.982671e-01 0.400 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.982671e-01 0.400 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.982671e-01 0.400 0 0
Mismatch Repair R-HSA-5358508 3.982671e-01 0.400 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 3.982671e-01 0.400 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 3.982671e-01 0.400 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.982671e-01 0.400 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 3.982671e-01 0.400 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 3.982671e-01 0.400 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.018505e-01 0.396 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.018505e-01 0.396 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.018505e-01 0.396 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.018505e-01 0.396 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.050199e-01 0.393 0 0
tRNA processing in the nucleus R-HSA-6784531 4.050199e-01 0.393 0 0
PCP/CE pathway R-HSA-4086400 4.063702e-01 0.391 0 0
Nuclear RNA decay R-HSA-9930044 4.106924e-01 0.386 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.106924e-01 0.386 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.106924e-01 0.386 0 0
Neutrophil degranulation R-HSA-6798695 4.131268e-01 0.384 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.142065e-01 0.383 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.150999e-01 0.382 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.153232e-01 0.382 0 0
STAT5 Activation R-HSA-9645135 4.153232e-01 0.382 0 0
Autointegration results in viral DNA circles R-HSA-177539 4.153232e-01 0.382 0 0
Uncoating of the HIV Virion R-HSA-162585 4.153232e-01 0.382 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 4.153232e-01 0.382 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 4.153232e-01 0.382 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 4.153232e-01 0.382 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 4.153232e-01 0.382 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 4.153232e-01 0.382 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 4.153232e-01 0.382 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.153232e-01 0.382 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 4.153232e-01 0.382 0 0
Gene Silencing by RNA R-HSA-211000 4.153902e-01 0.382 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.166351e-01 0.380 0 0
Translesion Synthesis by POLH R-HSA-110320 4.188593e-01 0.378 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.188593e-01 0.378 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.188593e-01 0.378 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.188593e-01 0.378 0 0
Other interleukin signaling R-HSA-449836 4.188593e-01 0.378 0 0
Potential therapeutics for SARS R-HSA-9679191 4.189116e-01 0.378 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.264006e-01 0.370 0 0
Ion transport by P-type ATPases R-HSA-936837 4.282129e-01 0.368 0 0
GPER1 signaling R-HSA-9634597 4.282830e-01 0.368 0 0
Vesicle-mediated transport R-HSA-5653656 4.290730e-01 0.367 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.354705e-01 0.361 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.376901e-01 0.359 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.390862e-01 0.357 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.390862e-01 0.357 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.390862e-01 0.357 0 0
Negative regulation of MET activity R-HSA-6807004 4.390862e-01 0.357 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.390862e-01 0.357 0 0
Signal transduction by L1 R-HSA-445144 4.390862e-01 0.357 0 0
Cellular response to hypoxia R-HSA-1234174 4.397442e-01 0.357 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.413872e-01 0.355 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.413872e-01 0.355 0 0
Dual Incision in GG-NER R-HSA-5696400 4.419592e-01 0.355 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.419592e-01 0.355 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.419592e-01 0.355 0 0
HCMV Infection R-HSA-9609646 4.436780e-01 0.353 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.463393e-01 0.350 0 0
Death Receptor Signaling R-HSA-73887 4.488726e-01 0.348 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.491801e-01 0.348 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 4.491801e-01 0.348 0 0
Disinhibition of SNARE formation R-HSA-114516 4.491801e-01 0.348 0 0
mRNA Editing: C to U Conversion R-HSA-72200 4.491801e-01 0.348 0 0
PTK6 Expression R-HSA-8849473 4.491801e-01 0.348 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.491801e-01 0.348 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.491801e-01 0.348 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.491801e-01 0.348 0 0
Netrin mediated repulsion signals R-HSA-418886 4.491801e-01 0.348 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.545288e-01 0.342 0 0
PPARA activates gene expression R-HSA-1989781 4.563426e-01 0.341 0 0
Regulation of Apoptosis R-HSA-169911 4.573507e-01 0.340 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.573507e-01 0.340 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.589210e-01 0.338 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.589210e-01 0.338 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.589210e-01 0.338 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.589210e-01 0.338 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 4.589210e-01 0.338 0 0
FCERI mediated MAPK activation R-HSA-2871796 4.597720e-01 0.337 0 0
Parasite infection R-HSA-9664407 4.601094e-01 0.337 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.601094e-01 0.337 0 0
Leishmania phagocytosis R-HSA-9664417 4.601094e-01 0.337 0 0
Telomere Maintenance R-HSA-157579 4.640105e-01 0.333 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.673124e-01 0.330 0 0
HSF1-dependent transactivation R-HSA-3371571 4.673124e-01 0.330 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.673124e-01 0.330 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.712404e-01 0.327 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.725592e-01 0.326 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.725592e-01 0.326 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.725592e-01 0.326 0 0
Deubiquitination R-HSA-5688426 4.734469e-01 0.325 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.739760e-01 0.324 0 0
Regulated Necrosis R-HSA-5218859 4.739760e-01 0.324 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.783414e-01 0.320 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.783414e-01 0.320 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.783414e-01 0.320 0 0
Ribavirin ADME R-HSA-9755088 4.783414e-01 0.320 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.789291e-01 0.320 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.801118e-01 0.319 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.801118e-01 0.319 0 0
Orc1 removal from chromatin R-HSA-68949 4.801118e-01 0.319 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.801118e-01 0.319 0 0
Reverse Transcription of HIV RNA R-HSA-162589 4.810784e-01 0.318 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.810784e-01 0.318 0 0
Minus-strand DNA synthesis R-HSA-164516 4.810784e-01 0.318 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.810784e-01 0.318 0 0
MET receptor recycling R-HSA-8875656 4.810784e-01 0.318 0 0
Formation of annular gap junctions R-HSA-196025 4.810784e-01 0.318 0 0
Type I hemidesmosome assembly R-HSA-446107 4.810784e-01 0.318 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.810784e-01 0.318 0 0
Fructose biosynthesis R-HSA-5652227 4.810784e-01 0.318 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.810784e-01 0.318 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.810784e-01 0.318 0 0
phospho-PLA2 pathway R-HSA-111995 4.810784e-01 0.318 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.810784e-01 0.318 0 0
Alpha-defensins R-HSA-1462054 4.810784e-01 0.318 0 0
Adrenoceptors R-HSA-390696 4.810784e-01 0.318 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.810784e-01 0.318 0 0
RSK activation R-HSA-444257 4.810784e-01 0.318 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.810784e-01 0.318 0 0
HATs acetylate histones R-HSA-3214847 4.828551e-01 0.316 0 0
Disease R-HSA-1643685 4.843984e-01 0.315 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.852395e-01 0.314 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 4.875702e-01 0.312 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.875702e-01 0.312 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.912952e-01 0.309 0 0
Glycolysis R-HSA-70171 4.922087e-01 0.308 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.927890e-01 0.307 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.927890e-01 0.307 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.927890e-01 0.307 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.964172e-01 0.304 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.973290e-01 0.303 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.973290e-01 0.303 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.973290e-01 0.303 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 4.973290e-01 0.303 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 4.973290e-01 0.303 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.992157e-01 0.302 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.992157e-01 0.302 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.023706e-01 0.299 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.023706e-01 0.299 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.053350e-01 0.296 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.075025e-01 0.295 0 0
Gap junction degradation R-HSA-190873 5.111313e-01 0.291 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.111313e-01 0.291 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.111313e-01 0.291 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.111313e-01 0.291 0 0
Calcineurin activates NFAT R-HSA-2025928 5.111313e-01 0.291 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.111313e-01 0.291 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.111313e-01 0.291 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.111313e-01 0.291 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.111313e-01 0.291 0 0
mRNA Editing R-HSA-75072 5.111313e-01 0.291 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 5.111313e-01 0.291 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.111313e-01 0.291 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 5.158686e-01 0.287 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.169484e-01 0.287 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.177412e-01 0.286 0 0
HDACs deacetylate histones R-HSA-3214815 5.177412e-01 0.286 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.184889e-01 0.285 0 0
Developmental Cell Lineages R-HSA-9734767 5.205834e-01 0.284 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.292036e-01 0.276 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.299996e-01 0.276 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.299996e-01 0.276 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.312932e-01 0.275 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.312932e-01 0.275 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.312932e-01 0.275 0 0
Deadenylation of mRNA R-HSA-429947 5.339485e-01 0.273 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.339485e-01 0.273 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.339485e-01 0.273 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.339485e-01 0.273 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.339485e-01 0.273 0 0
Gastrulation R-HSA-9758941 5.371685e-01 0.270 0 0
Binding and entry of HIV virion R-HSA-173107 5.394454e-01 0.268 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.394454e-01 0.268 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.394454e-01 0.268 0 0
2-LTR circle formation R-HSA-164843 5.394454e-01 0.268 0 0
Pexophagy R-HSA-9664873 5.394454e-01 0.268 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.394454e-01 0.268 0 0
Tandem pore domain potassium channels R-HSA-1296346 5.394454e-01 0.268 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.394454e-01 0.268 0 0
Formation of apoptosome R-HSA-111458 5.394454e-01 0.268 0 0
Viral Infection Pathways R-HSA-9824446 5.398584e-01 0.268 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.453955e-01 0.263 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 5.453955e-01 0.263 0 0
SARS-CoV Infections R-HSA-9679506 5.474672e-01 0.262 0 0
Protein ubiquitination R-HSA-8852135 5.507958e-01 0.259 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.515599e-01 0.258 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.515599e-01 0.258 0 0
G protein gated Potassium channels R-HSA-1296059 5.515599e-01 0.258 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.515599e-01 0.258 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.515599e-01 0.258 0 0
Tight junction interactions R-HSA-420029 5.515599e-01 0.258 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 5.515599e-01 0.258 0 0
Long-term potentiation R-HSA-9620244 5.515599e-01 0.258 0 0
Hyaluronan degradation R-HSA-2160916 5.515599e-01 0.258 0 0
Dual incision in TC-NER R-HSA-6782135 5.540447e-01 0.256 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.592472e-01 0.252 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.592472e-01 0.252 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.592472e-01 0.252 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.613295e-01 0.251 0 0
Synthesis of DNA R-HSA-69239 5.648442e-01 0.248 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.658185e-01 0.247 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.661212e-01 0.247 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.661212e-01 0.247 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 5.661212e-01 0.247 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.661212e-01 0.247 0 0
Dissolution of Fibrin Clot R-HSA-75205 5.661212e-01 0.247 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.661212e-01 0.247 0 0
Signaling by APC mutants R-HSA-4839744 5.661212e-01 0.247 0 0
vRNP Assembly R-HSA-192905 5.661212e-01 0.247 0 0
Formation of the posterior neural plate R-HSA-9832991 5.661212e-01 0.247 0 0
Transport of RCbl within the body R-HSA-9758890 5.661212e-01 0.247 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 5.661212e-01 0.247 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 5.661212e-01 0.247 0 0
Prostanoid ligand receptors R-HSA-391908 5.661212e-01 0.247 0 0
Interleukin-2 signaling R-HSA-9020558 5.661212e-01 0.247 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.686962e-01 0.245 0 0
Myogenesis R-HSA-525793 5.686962e-01 0.245 0 0
Metalloprotease DUBs R-HSA-5689901 5.686962e-01 0.245 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.686962e-01 0.245 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.686962e-01 0.245 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.708358e-01 0.243 0 0
MTOR signalling R-HSA-165159 5.728410e-01 0.242 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.735947e-01 0.241 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.742367e-01 0.241 0 0
tRNA Aminoacylation R-HSA-379724 5.774189e-01 0.239 0 0
RNA Polymerase I Transcription R-HSA-73864 5.820160e-01 0.235 0 0
G alpha (12/13) signalling events R-HSA-416482 5.820160e-01 0.235 0 0
Ion channel transport R-HSA-983712 5.843277e-01 0.233 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.853535e-01 0.233 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.853535e-01 0.233 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.853535e-01 0.233 0 0
TBC/RABGAPs R-HSA-8854214 5.861707e-01 0.232 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.861707e-01 0.232 0 0
MAP kinase activation R-HSA-450294 5.888410e-01 0.230 0 0
DS-GAG biosynthesis R-HSA-2022923 5.912535e-01 0.228 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.912535e-01 0.228 0 0
ERKs are inactivated R-HSA-202670 5.912535e-01 0.228 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.912535e-01 0.228 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.912535e-01 0.228 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.912535e-01 0.228 0 0
NF-kB is activated and signals survival R-HSA-209560 5.912535e-01 0.228 0 0
Scavenging by Class H Receptors R-HSA-3000497 5.912535e-01 0.228 0 0
Signaling by AXIN mutants R-HSA-4839735 5.912535e-01 0.228 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.912535e-01 0.228 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.912535e-01 0.228 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.912535e-01 0.228 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 5.912535e-01 0.228 0 0
Sensory processing of sound R-HSA-9659379 5.921604e-01 0.228 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.931738e-01 0.227 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.931738e-01 0.227 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.990560e-01 0.223 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.992314e-01 0.222 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.000801e-01 0.222 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.000801e-01 0.222 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.015298e-01 0.221 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.120186e-01 0.213 0 0
Somitogenesis R-HSA-9824272 6.120186e-01 0.213 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.149314e-01 0.211 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.149314e-01 0.211 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.149314e-01 0.211 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.149314e-01 0.211 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.149314e-01 0.211 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 6.149314e-01 0.211 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 6.149314e-01 0.211 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.149314e-01 0.211 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.149314e-01 0.211 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.149314e-01 0.211 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 6.149314e-01 0.211 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.149314e-01 0.211 0 0
Polymerase switching R-HSA-69091 6.149314e-01 0.211 0 0
Leading Strand Synthesis R-HSA-69109 6.149314e-01 0.211 0 0
Pervasive developmental disorders R-HSA-9005895 6.149314e-01 0.211 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.149314e-01 0.211 0 0
Disorders of Nervous System Development R-HSA-9697154 6.149314e-01 0.211 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.149314e-01 0.211 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.149314e-01 0.211 0 0
Signaling by TGFB family members R-HSA-9006936 6.169469e-01 0.210 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.172248e-01 0.210 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.172248e-01 0.210 0 0
Signaling by WNT R-HSA-195721 6.196985e-01 0.208 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.219942e-01 0.206 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.293327e-01 0.201 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.313310e-01 0.200 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.314332e-01 0.200 0 0
Regulation of insulin secretion R-HSA-422356 6.314332e-01 0.200 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.323565e-01 0.199 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.324401e-01 0.199 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.324401e-01 0.199 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.324401e-01 0.199 0 0
Interleukin-37 signaling R-HSA-9008059 6.324401e-01 0.199 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.367599e-01 0.196 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.372390e-01 0.196 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.372390e-01 0.196 0 0
Diseases of nucleotide metabolism R-HSA-9735804 6.372390e-01 0.196 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.372390e-01 0.196 0 0
Maturation of nucleoprotein R-HSA-9683610 6.372390e-01 0.196 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.372390e-01 0.196 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.372390e-01 0.196 0 0
Interleukin-6 signaling R-HSA-1059683 6.372390e-01 0.196 0 0
Trafficking of AMPA receptors R-HSA-399719 6.471785e-01 0.189 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.471785e-01 0.189 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.471785e-01 0.189 0 0
Cell-cell junction organization R-HSA-421270 6.485098e-01 0.188 0 0
Circadian clock R-HSA-9909396 6.560190e-01 0.183 0 0
Removal of the Flap Intermediate R-HSA-69166 6.582556e-01 0.182 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.582556e-01 0.182 0 0
HDL assembly R-HSA-8963896 6.582556e-01 0.182 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.582556e-01 0.182 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.582556e-01 0.182 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.582556e-01 0.182 0 0
Non-canonical inflammasome activation R-HSA-9686114 6.582556e-01 0.182 0 0
Acyl chain remodeling of CL R-HSA-1482798 6.582556e-01 0.182 0 0
Adherens junctions interactions R-HSA-418990 6.614161e-01 0.180 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.614443e-01 0.180 0 0
Glucose metabolism R-HSA-70326 6.637836e-01 0.178 0 0
Mitochondrial biogenesis R-HSA-1592230 6.637836e-01 0.178 0 0
Cell surface interactions at the vascular wall R-HSA-202733 6.685368e-01 0.175 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.752427e-01 0.171 0 0
Cardiogenesis R-HSA-9733709 6.752427e-01 0.171 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.780558e-01 0.169 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.780558e-01 0.169 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.780558e-01 0.169 0 0
p75NTR signals via NF-kB R-HSA-193639 6.780558e-01 0.169 0 0
Translesion synthesis by REV1 R-HSA-110312 6.780558e-01 0.169 0 0
Transport and metabolism of PAPS R-HSA-174362 6.780558e-01 0.169 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.780558e-01 0.169 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.780558e-01 0.169 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.780558e-01 0.169 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 6.780558e-01 0.169 0 0
Protein methylation R-HSA-8876725 6.780558e-01 0.169 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.780558e-01 0.169 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.780558e-01 0.169 0 0
Meiotic recombination R-HSA-912446 6.828624e-01 0.166 0 0
Interleukin-17 signaling R-HSA-448424 6.830285e-01 0.166 0 0
Signaling by NOTCH R-HSA-157118 6.847483e-01 0.164 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.885799e-01 0.162 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.885799e-01 0.162 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.885799e-01 0.162 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.885799e-01 0.162 0 0
Integration of energy metabolism R-HSA-163685 6.912686e-01 0.160 0 0
Hedgehog 'on' state R-HSA-5632684 6.924968e-01 0.160 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 6.936817e-01 0.159 0 0
Neurexins and neuroligins R-HSA-6794361 6.936817e-01 0.159 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.936817e-01 0.159 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.967099e-01 0.157 0 0
Translesion synthesis by POLI R-HSA-5656121 6.967099e-01 0.157 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.967099e-01 0.157 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.967099e-01 0.157 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 6.967099e-01 0.157 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.967099e-01 0.157 0 0
Atorvastatin ADME R-HSA-9754706 6.967099e-01 0.157 0 0
Negative regulation of FLT3 R-HSA-9706369 6.967099e-01 0.157 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.967099e-01 0.157 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.967099e-01 0.157 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.967099e-01 0.157 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.970265e-01 0.157 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.980370e-01 0.156 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.013757e-01 0.154 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.014631e-01 0.154 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.014631e-01 0.154 0 0
Signaling by NOTCH2 R-HSA-1980145 7.014631e-01 0.154 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.014631e-01 0.154 0 0
Signal amplification R-HSA-392518 7.014631e-01 0.154 0 0
Mitophagy R-HSA-5205647 7.014631e-01 0.154 0 0
Hyaluronan metabolism R-HSA-2142845 7.014631e-01 0.154 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.014631e-01 0.154 0 0
Nucleotide biosynthesis R-HSA-8956320 7.042199e-01 0.152 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.055756e-01 0.151 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.106020e-01 0.148 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.139000e-01 0.146 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.139000e-01 0.146 0 0
Translesion synthesis by POLK R-HSA-5655862 7.142842e-01 0.146 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 7.142842e-01 0.146 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 7.142842e-01 0.146 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.142842e-01 0.146 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.142842e-01 0.146 0 0
Scavenging by Class B Receptors R-HSA-3000471 7.142842e-01 0.146 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 7.142842e-01 0.146 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.142842e-01 0.146 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.142842e-01 0.146 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.142842e-01 0.146 0 0
Passive transport by Aquaporins R-HSA-432047 7.142842e-01 0.146 0 0
Fibronectin matrix formation R-HSA-1566977 7.142842e-01 0.146 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.142842e-01 0.146 0 0
Disorders of Developmental Biology R-HSA-9675151 7.142842e-01 0.146 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 7.142842e-01 0.146 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 7.142842e-01 0.146 0 0
Stimuli-sensing channels R-HSA-2672351 7.195030e-01 0.143 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.258992e-01 0.139 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.258992e-01 0.139 0 0
RNA Polymerase III Transcription R-HSA-74158 7.258992e-01 0.139 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.282084e-01 0.138 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.282084e-01 0.138 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.282084e-01 0.138 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.308412e-01 0.136 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 7.308412e-01 0.136 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 7.308412e-01 0.136 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.308412e-01 0.136 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.308412e-01 0.136 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.338307e-01 0.134 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.338307e-01 0.134 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.341821e-01 0.134 0 0
UCH proteinases R-HSA-5689603 7.367966e-01 0.133 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.374696e-01 0.132 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.374696e-01 0.132 0 0
Degradation of DVL R-HSA-4641258 7.374696e-01 0.132 0 0
Collagen chain trimerization R-HSA-8948216 7.374696e-01 0.132 0 0
Synthesis of PA R-HSA-1483166 7.436021e-01 0.129 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.464396e-01 0.127 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.464396e-01 0.127 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.464396e-01 0.127 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.464396e-01 0.127 0 0
Purine salvage R-HSA-74217 7.486206e-01 0.126 0 0
SLC-mediated transport of organic anions R-HSA-9955298 7.531091e-01 0.123 0 0
ABC transporter disorders R-HSA-5619084 7.531091e-01 0.123 0 0
Integrin cell surface interactions R-HSA-216083 7.531091e-01 0.123 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 7.593618e-01 0.120 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.593618e-01 0.120 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.593618e-01 0.120 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.611350e-01 0.119 0 0
Specification of the neural plate border R-HSA-9834899 7.611350e-01 0.119 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.611350e-01 0.119 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.611350e-01 0.119 0 0
The NLRP3 inflammasome R-HSA-844456 7.611350e-01 0.119 0 0
Maturation of nucleoprotein R-HSA-9694631 7.611350e-01 0.119 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.611350e-01 0.119 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.611350e-01 0.119 0 0
Crosslinking of collagen fibrils R-HSA-2243919 7.611350e-01 0.119 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.616691e-01 0.118 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.629589e-01 0.117 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 7.634017e-01 0.117 0 0
Generation of second messenger molecules R-HSA-202433 7.697034e-01 0.114 0 0
Diseases of Immune System R-HSA-5260271 7.697034e-01 0.114 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.697034e-01 0.114 0 0
Glycogen metabolism R-HSA-8982491 7.697034e-01 0.114 0 0
Phospholipid metabolism R-HSA-1483257 7.730456e-01 0.112 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.749795e-01 0.111 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.749795e-01 0.111 0 0
Protein hydroxylation R-HSA-9629569 7.749795e-01 0.111 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.749795e-01 0.111 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.770722e-01 0.110 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.770722e-01 0.110 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.770722e-01 0.110 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.778943e-01 0.109 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.796555e-01 0.108 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 7.796555e-01 0.108 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.880223e-01 0.103 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.880223e-01 0.103 0 0
ERK/MAPK targets R-HSA-198753 7.880223e-01 0.103 0 0
Lagging Strand Synthesis R-HSA-69186 7.880223e-01 0.103 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.880223e-01 0.103 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.880223e-01 0.103 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.880223e-01 0.103 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.880223e-01 0.103 0 0
Basigin interactions R-HSA-210991 7.880223e-01 0.103 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 7.880223e-01 0.103 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.892285e-01 0.103 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.892285e-01 0.103 0 0
Scavenging by Class A Receptors R-HSA-3000480 7.892285e-01 0.103 0 0
ABC-family proteins mediated transport R-HSA-382556 7.901278e-01 0.102 0 0
Interleukin-1 signaling R-HSA-9020702 7.964285e-01 0.099 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.973718e-01 0.098 0 0
Activation of GABAB receptors R-HSA-991365 7.984330e-01 0.098 0 0
GABA B receptor activation R-HSA-977444 7.984330e-01 0.098 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.984330e-01 0.098 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 7.984330e-01 0.098 0 0
Ca-dependent events R-HSA-111996 7.984330e-01 0.098 0 0
CS-GAG biosynthesis R-HSA-2022870 8.003100e-01 0.097 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.003100e-01 0.097 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.003100e-01 0.097 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.003100e-01 0.097 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.003100e-01 0.097 0 0
Assembly Of The HIV Virion R-HSA-175474 8.003100e-01 0.097 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.033107e-01 0.095 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.033107e-01 0.095 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.040893e-01 0.095 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.072794e-01 0.093 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.106249e-01 0.091 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.118860e-01 0.091 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.118860e-01 0.091 0 0
Free fatty acid receptors R-HSA-444209 8.118860e-01 0.091 0 0
LDL clearance R-HSA-8964038 8.118860e-01 0.091 0 0
Fructose metabolism R-HSA-5652084 8.118860e-01 0.091 0 0
Ethanol oxidation R-HSA-71384 8.118860e-01 0.091 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.118860e-01 0.091 0 0
Proteasome assembly R-HSA-9907900 8.157783e-01 0.088 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.195988e-01 0.086 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.195988e-01 0.086 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.201532e-01 0.086 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.201532e-01 0.086 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.227916e-01 0.085 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.227916e-01 0.085 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.227916e-01 0.085 0 0
Carnitine shuttle R-HSA-200425 8.227916e-01 0.085 0 0
Formation of the ureteric bud R-HSA-9830674 8.227916e-01 0.085 0 0
Biosynthesis of maresins R-HSA-9018682 8.227916e-01 0.085 0 0
Kidney development R-HSA-9830369 8.238172e-01 0.084 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 8.239403e-01 0.084 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 8.239403e-01 0.084 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.239403e-01 0.084 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.239403e-01 0.084 0 0
Formation of the cornified envelope R-HSA-6809371 8.298525e-01 0.081 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.305217e-01 0.081 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.317759e-01 0.080 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.317759e-01 0.080 0 0
Signaling by TGFBR3 R-HSA-9839373 8.317759e-01 0.080 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.330657e-01 0.079 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.330657e-01 0.079 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.330657e-01 0.079 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.330657e-01 0.079 0 0
Interleukin-6 family signaling R-HSA-6783589 8.330657e-01 0.079 0 0
ER-Phagosome pathway R-HSA-1236974 8.350038e-01 0.078 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.392954e-01 0.076 0 0
Synthesis of PC R-HSA-1483191 8.392954e-01 0.076 0 0
G1/S Transition R-HSA-69206 8.396351e-01 0.076 0 0
Co-inhibition by PD-1 R-HSA-389948 8.396521e-01 0.076 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.416000e-01 0.075 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.427446e-01 0.074 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.427446e-01 0.074 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.427446e-01 0.074 0 0
TGFBR3 expression R-HSA-9839394 8.427446e-01 0.074 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.432752e-01 0.074 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.432752e-01 0.074 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.466205e-01 0.072 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.466205e-01 0.072 0 0
Metabolism of cofactors R-HSA-8978934 8.493344e-01 0.071 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.518629e-01 0.070 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.518629e-01 0.070 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.518629e-01 0.070 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.518629e-01 0.070 0 0
Urea cycle R-HSA-70635 8.518629e-01 0.070 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.518629e-01 0.070 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.518629e-01 0.070 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.534273e-01 0.069 0 0
Azathioprine ADME R-HSA-9748787 8.600599e-01 0.065 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.604530e-01 0.065 0 0
Packaging Of Telomere Ends R-HSA-171306 8.604530e-01 0.065 0 0
Cristae formation R-HSA-8949613 8.604530e-01 0.065 0 0
Signaling by BMP R-HSA-201451 8.604530e-01 0.065 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.604530e-01 0.065 0 0
Triglyceride biosynthesis R-HSA-75109 8.604530e-01 0.065 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.604530e-01 0.065 0 0
Inositol phosphate metabolism R-HSA-1483249 8.608973e-01 0.065 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.617340e-01 0.065 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.645062e-01 0.063 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.654020e-01 0.063 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.654020e-01 0.063 0 0
ROS and RNS production in phagocytes R-HSA-1222556 8.663029e-01 0.062 0 0
Complex IV assembly R-HSA-9864848 8.664167e-01 0.062 0 0
The phototransduction cascade R-HSA-2514856 8.664167e-01 0.062 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.664167e-01 0.062 0 0
Insulin receptor recycling R-HSA-77387 8.685455e-01 0.061 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.685455e-01 0.061 0 0
Inflammasomes R-HSA-622312 8.685455e-01 0.061 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.685455e-01 0.061 0 0
Prednisone ADME R-HSA-9757110 8.685455e-01 0.061 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 8.715730e-01 0.060 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.715730e-01 0.060 0 0
Late endosomal microautophagy R-HSA-9615710 8.761691e-01 0.057 0 0
DNA methylation R-HSA-5334118 8.761691e-01 0.057 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 8.761691e-01 0.057 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.781850e-01 0.056 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.783416e-01 0.056 0 0
Innate Immune System R-HSA-168249 8.787829e-01 0.056 0 0
Interleukin-1 family signaling R-HSA-446652 8.794364e-01 0.056 0 0
DNA Replication R-HSA-69306 8.829476e-01 0.054 0 0
Activation of the pre-replicative complex R-HSA-68962 8.833511e-01 0.054 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.833511e-01 0.054 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.833511e-01 0.054 0 0
Neurotransmitter clearance R-HSA-112311 8.833511e-01 0.054 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.833511e-01 0.054 0 0
Activation of BH3-only proteins R-HSA-114452 8.833511e-01 0.054 0 0
Cholesterol biosynthesis R-HSA-191273 8.862965e-01 0.052 0 0
Rab regulation of trafficking R-HSA-9007101 8.899197e-01 0.051 0 0
Budding and maturation of HIV virion R-HSA-162588 8.901169e-01 0.051 0 0
Cargo concentration in the ER R-HSA-5694530 8.901169e-01 0.051 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.901169e-01 0.051 0 0
TNF signaling R-HSA-75893 8.943957e-01 0.048 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.943957e-01 0.048 0 0
DNA strand elongation R-HSA-69190 8.964907e-01 0.047 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.964907e-01 0.047 0 0
Dectin-2 family R-HSA-5621480 8.992939e-01 0.046 0 0
Interferon gamma signaling R-HSA-877300 9.022632e-01 0.045 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.024951e-01 0.045 0 0
G-protein beta:gamma signalling R-HSA-397795 9.024951e-01 0.045 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.024951e-01 0.045 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.024951e-01 0.045 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.039795e-01 0.044 0 0
CS/DS degradation R-HSA-2024101 9.081516e-01 0.042 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.081516e-01 0.042 0 0
Peroxisomal protein import R-HSA-9033241 9.084609e-01 0.042 0 0
Regulation of beta-cell development R-HSA-186712 9.084609e-01 0.042 0 0
GABA receptor activation R-HSA-977443 9.127458e-01 0.040 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.127458e-01 0.040 0 0
Metabolism of polyamines R-HSA-351202 9.127458e-01 0.040 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.134802e-01 0.039 0 0
eNOS activation R-HSA-203615 9.134802e-01 0.039 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.134802e-01 0.039 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.134802e-01 0.039 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.134802e-01 0.039 0 0
RSV-host interactions R-HSA-9833110 9.144930e-01 0.039 0 0
Collagen degradation R-HSA-1442490 9.168421e-01 0.038 0 0
Nucleotide salvage R-HSA-8956321 9.168421e-01 0.038 0 0
PLC beta mediated events R-HSA-112043 9.168421e-01 0.038 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.181514e-01 0.037 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.185000e-01 0.037 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 9.185000e-01 0.037 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.198598e-01 0.036 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.214776e-01 0.036 0 0
G1/S-Specific Transcription R-HSA-69205 9.232288e-01 0.035 0 0
Calmodulin induced events R-HSA-111933 9.232288e-01 0.035 0 0
CaM pathway R-HSA-111997 9.232288e-01 0.035 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.232288e-01 0.035 0 0
SLC transporter disorders R-HSA-5619102 9.237428e-01 0.034 0 0
Cleavage of the damaged purine R-HSA-110331 9.276836e-01 0.033 0 0
NCAM1 interactions R-HSA-419037 9.276836e-01 0.033 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.276836e-01 0.033 0 0
Xenobiotics R-HSA-211981 9.280721e-01 0.032 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.318801e-01 0.031 0 0
Depurination R-HSA-73927 9.318801e-01 0.031 0 0
Elastic fibre formation R-HSA-1566948 9.318801e-01 0.031 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.318801e-01 0.031 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.318801e-01 0.031 0 0
Toll-like Receptor Cascades R-HSA-168898 9.321154e-01 0.031 0 0
tRNA processing R-HSA-72306 9.328532e-01 0.030 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.347459e-01 0.029 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.358333e-01 0.029 0 0
G-protein mediated events R-HSA-112040 9.378586e-01 0.028 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.395573e-01 0.027 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.395573e-01 0.027 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.408301e-01 0.026 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.430654e-01 0.025 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.430654e-01 0.025 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.430654e-01 0.025 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.430654e-01 0.025 0 0
FCGR activation R-HSA-2029481 9.445507e-01 0.025 0 0
Leishmania infection R-HSA-9658195 9.453635e-01 0.024 0 0
Parasitic Infection Pathways R-HSA-9824443 9.453635e-01 0.024 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.463701e-01 0.024 0 0
Translation of Structural Proteins R-HSA-9683701 9.463701e-01 0.024 0 0
COPII-mediated vesicle transport R-HSA-204005 9.463728e-01 0.024 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.464100e-01 0.024 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.468215e-01 0.024 0 0
Collagen formation R-HSA-1474290 9.469147e-01 0.024 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.485036e-01 0.023 0 0
ECM proteoglycans R-HSA-3000178 9.489551e-01 0.023 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.491847e-01 0.023 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.494832e-01 0.023 0 0
Depyrimidination R-HSA-73928 9.494832e-01 0.023 0 0
Infectious disease R-HSA-5663205 9.509802e-01 0.022 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.514186e-01 0.022 0 0
Defective pyroptosis R-HSA-9710421 9.524157e-01 0.021 0 0
Defensins R-HSA-1461973 9.524157e-01 0.021 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.524157e-01 0.021 0 0
RMTs methylate histone arginines R-HSA-3214858 9.551782e-01 0.020 0 0
Amine ligand-binding receptors R-HSA-375280 9.551782e-01 0.020 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.551782e-01 0.020 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.577804e-01 0.019 0 0
DAG and IP3 signaling R-HSA-1489509 9.577804e-01 0.019 0 0
Iron uptake and transport R-HSA-917937 9.581458e-01 0.019 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.602317e-01 0.018 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.602317e-01 0.018 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.602317e-01 0.018 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.602317e-01 0.018 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.625409e-01 0.017 0 0
Post-translational protein modification R-HSA-597592 9.633132e-01 0.016 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.643404e-01 0.016 0 0
Gluconeogenesis R-HSA-70263 9.647160e-01 0.016 0 0
NGF-stimulated transcription R-HSA-9031628 9.647160e-01 0.016 0 0
Metal ion SLC transporters R-HSA-425410 9.647160e-01 0.016 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.705133e-01 0.013 0 0
Platelet homeostasis R-HSA-418346 9.715312e-01 0.013 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.716264e-01 0.013 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.719977e-01 0.012 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.733809e-01 0.012 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.737592e-01 0.012 0 0
Protein localization R-HSA-9609507 9.747688e-01 0.011 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.753589e-01 0.011 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.759522e-01 0.011 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.767904e-01 0.010 0 0
G alpha (z) signalling events R-HSA-418597 9.767904e-01 0.010 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.771460e-01 0.010 0 0
Antimicrobial peptides R-HSA-6803157 9.773338e-01 0.010 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.781168e-01 0.010 0 0
HCMV Late Events R-HSA-9610379 9.784565e-01 0.009 0 0
Neurotransmitter release cycle R-HSA-112310 9.813729e-01 0.008 0 0
Base Excision Repair R-HSA-73884 9.813729e-01 0.008 0 0
Triglyceride metabolism R-HSA-8979227 9.817323e-01 0.008 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.823048e-01 0.008 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.827938e-01 0.008 0 0
Peptide ligand-binding receptors R-HSA-375276 9.828154e-01 0.008 0 0
Aquaporin-mediated transport R-HSA-445717 9.837937e-01 0.007 0 0
Endogenous sterols R-HSA-211976 9.837937e-01 0.007 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.840348e-01 0.007 0 0
Peptide hormone metabolism R-HSA-2980736 9.843424e-01 0.007 0 0
Mitochondrial protein import R-HSA-1268020 9.847356e-01 0.007 0 0
Mitochondrial protein degradation R-HSA-9837999 9.855999e-01 0.006 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.870156e-01 0.006 0 0
G alpha (s) signalling events R-HSA-418555 9.882573e-01 0.005 0 0
Nicotinate metabolism R-HSA-196807 9.886854e-01 0.005 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.891459e-01 0.005 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.891873e-01 0.005 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.891873e-01 0.005 0 0
O-linked glycosylation of mucins R-HSA-913709 9.893432e-01 0.005 0 0
GPCR downstream signalling R-HSA-388396 9.899126e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.902200e-01 0.004 0 0
Metabolism of proteins R-HSA-392499 9.902529e-01 0.004 0 0
Sphingolipid metabolism R-HSA-428157 9.904045e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.910962e-01 0.004 0 0
Retinoid metabolism and transport R-HSA-975634 9.910962e-01 0.004 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.916139e-01 0.004 0 0
Purine catabolism R-HSA-74259 9.916139e-01 0.004 0 0
Opioid Signalling R-HSA-111885 9.918761e-01 0.004 0 0
Aspirin ADME R-HSA-9749641 9.921016e-01 0.003 0 0
Bacterial Infection Pathways R-HSA-9824439 9.922733e-01 0.003 0 0
Metabolism of steroids R-HSA-8957322 9.922926e-01 0.003 0 0
Keratinization R-HSA-6805567 9.924417e-01 0.003 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.931740e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9694635 9.937851e-01 0.003 0 0
Extracellular matrix organization R-HSA-1474244 9.939082e-01 0.003 0 0
Amyloid fiber formation R-HSA-977225 9.951100e-01 0.002 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.951100e-01 0.002 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.951100e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.961207e-01 0.002 0 0
Signaling by GPCR R-HSA-372790 9.962494e-01 0.002 0 0
Pyruvate metabolism R-HSA-70268 9.967861e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.969375e-01 0.001 0 0
Respiratory electron transport R-HSA-611105 9.973230e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.977576e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.978027e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.983388e-01 0.001 0 0
Sensory perception of taste R-HSA-9717189 9.985218e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.985267e-01 0.001 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.986733e-01 0.001 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.989087e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.990322e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.990887e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.990965e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.992833e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.992863e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.995464e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.996189e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.997260e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.997967e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.998150e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.998201e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998644e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999015e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999072e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999085e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999353e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999609e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999657e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999870e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999936e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999943e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999954e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999988e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999998e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 4.949707e-12 11.305 0 0
Metabolism of RNA R-HSA-8953854 8.005818e-12 11.097 0 0
Cell Cycle, Mitotic R-HSA-69278 1.011489e-10 9.995 0 0
M Phase R-HSA-68886 2.357874e-09 8.627 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.745071e-09 8.561 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.885824e-08 7.724 0 0
Signaling by ALK in cancer R-HSA-9700206 1.885824e-08 7.724 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.810180e-08 7.167 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.810180e-08 7.167 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.132981e-08 7.212 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.132981e-08 7.212 0 0
mRNA Splicing R-HSA-72172 2.469409e-07 6.607 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.825664e-07 6.549 0 0
Nervous system development R-HSA-9675108 3.420488e-07 6.466 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.292979e-07 6.201 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.404491e-07 6.194 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.892756e-07 6.103 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.334617e-07 6.079 0 0
Axon guidance R-HSA-422475 8.704586e-07 6.060 0 0
Translation initiation complex formation R-HSA-72649 1.005095e-06 5.998 0 0
Mitotic Prometaphase R-HSA-68877 1.243907e-06 5.905 0 0
Cellular responses to stimuli R-HSA-8953897 1.767728e-06 5.753 1 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.354631e-06 5.628 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.998339e-06 5.523 0 0
Cell-Cell communication R-HSA-1500931 3.446479e-06 5.463 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.160731e-06 5.381 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.515920e-06 5.345 0 0
Mitotic Anaphase R-HSA-68882 5.112586e-06 5.291 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.610269e-06 5.251 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.730010e-06 5.242 0 0
Cellular responses to stress R-HSA-2262752 6.606095e-06 5.180 1 0
Nuclear Envelope Breakdown R-HSA-2980766 7.112941e-06 5.148 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.741275e-06 5.111 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.440410e-05 4.842 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.360986e-05 4.866 0 0
Separation of Sister Chromatids R-HSA-2467813 1.402375e-05 4.853 0 0
Cell Cycle Checkpoints R-HSA-69620 1.441039e-05 4.841 0 0
Interleukin-12 signaling R-HSA-9020591 1.518117e-05 4.819 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.730451e-05 4.762 0 0
Peptide chain elongation R-HSA-156902 2.241628e-05 4.649 0 0
Ribosome-associated quality control R-HSA-9948299 2.208045e-05 4.656 0 0
Influenza Infection R-HSA-168255 2.154374e-05 4.667 0 0
Cell junction organization R-HSA-446728 2.736958e-05 4.563 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.350105e-05 4.475 0 0
Signaling by ROBO receptors R-HSA-376176 3.704458e-05 4.431 0 0
Cellular response to heat stress R-HSA-3371556 3.819435e-05 4.418 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.312080e-05 4.365 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.312080e-05 4.365 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.555660e-05 4.341 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.592148e-05 4.338 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.292092e-05 4.276 0 0
rRNA processing R-HSA-72312 5.458653e-05 4.263 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.192592e-05 4.208 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.360645e-05 4.078 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.789369e-05 4.056 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.655831e-05 4.063 0 0
Eukaryotic Translation Termination R-HSA-72764 9.633195e-05 4.016 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.119848e-04 3.951 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.145627e-04 3.941 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.174555e-04 3.930 0 0
Interleukin-12 family signaling R-HSA-447115 1.228710e-04 3.911 0 0
Josephin domain DUBs R-HSA-5689877 1.321004e-04 3.879 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.321004e-04 3.879 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.588702e-04 3.799 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.721170e-04 3.764 0 0
Mitotic Prophase R-HSA-68875 1.678859e-04 3.775 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.861006e-04 3.730 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.861006e-04 3.730 0 0
Regulation of CDH1 Function R-HSA-9764561 1.892123e-04 3.723 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.095829e-04 3.679 0 0
Striated Muscle Contraction R-HSA-390522 2.217781e-04 3.654 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.217781e-04 3.654 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.393103e-04 3.621 0 0
HIV Life Cycle R-HSA-162587 2.411574e-04 3.618 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.971171e-04 3.527 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.152595e-04 3.501 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.279071e-04 3.484 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.296742e-04 3.482 0 0
Chromatin modifying enzymes R-HSA-3247509 4.050397e-04 3.393 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.338913e-04 3.363 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.494709e-04 3.347 0 0
Chromatin organization R-HSA-4839726 4.467552e-04 3.350 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.517596e-04 3.345 0 0
L1CAM interactions R-HSA-373760 4.733296e-04 3.325 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.765529e-04 3.322 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.392044e-04 3.268 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.231175e-04 3.281 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.231175e-04 3.281 0 0
Selenocysteine synthesis R-HSA-2408557 5.116659e-04 3.291 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.553821e-04 3.255 0 0
Viral mRNA Translation R-HSA-192823 6.590454e-04 3.181 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.050467e-04 3.043 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.576577e-04 3.067 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.777158e-04 3.057 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 9.135708e-04 3.039 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.164107e-04 3.038 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.422006e-04 3.026 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.713220e-04 3.013 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.101634e-03 2.958 0 0
Oncogene Induced Senescence R-HSA-2559585 1.112061e-03 2.954 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.048240e-03 2.980 0 0
Adherens junctions interactions R-HSA-418990 1.050188e-03 2.979 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.141215e-03 2.943 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.227571e-03 2.911 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.366509e-03 2.864 0 0
Signaling by RAS mutants R-HSA-6802949 1.398650e-03 2.854 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.398650e-03 2.854 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.398650e-03 2.854 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.398650e-03 2.854 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.366509e-03 2.864 0 0
Apoptotic execution phase R-HSA-75153 1.398650e-03 2.854 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.505000e-03 2.822 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.652629e-03 2.782 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.667555e-03 2.778 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.755151e-03 2.756 0 0
Smooth Muscle Contraction R-HSA-445355 1.755151e-03 2.756 0 0
G2/M Checkpoints R-HSA-69481 1.763193e-03 2.754 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.845178e-03 2.734 0 0
Cellular response to starvation R-HSA-9711097 1.854506e-03 2.732 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.021483e-03 2.694 0 0
HIV Infection R-HSA-162906 2.092581e-03 2.679 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.105409e-03 2.677 0 0
Late endosomal microautophagy R-HSA-9615710 2.305773e-03 2.637 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.435064e-03 2.613 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.234801e-03 2.651 0 0
Cellular Senescence R-HSA-2559583 2.278395e-03 2.642 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.435064e-03 2.613 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.376528e-03 2.624 0 0
Cell-cell junction organization R-HSA-421270 2.510796e-03 2.600 0 0
ALK mutants bind TKIs R-HSA-9700645 2.538726e-03 2.595 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.577085e-03 2.589 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.577085e-03 2.589 0 0
Apoptosis R-HSA-109581 2.626126e-03 2.581 0 0
Nuclear import of Rev protein R-HSA-180746 2.657393e-03 2.576 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.657393e-03 2.576 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.739014e-03 2.562 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.848956e-03 2.545 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.995938e-03 2.523 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.995938e-03 2.523 0 0
Protein ubiquitination R-HSA-8852135 3.133507e-03 2.504 0 0
EPH-Ephrin signaling R-HSA-2682334 3.168701e-03 2.499 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.915561e-03 2.535 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.214320e-03 2.493 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.490733e-03 2.457 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.490733e-03 2.457 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.618261e-03 2.442 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.648217e-03 2.438 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.741078e-03 2.427 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.579382e-03 2.339 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.610645e-03 2.336 0 0
Metabolism of non-coding RNA R-HSA-194441 4.302782e-03 2.366 0 0
snRNP Assembly R-HSA-191859 4.302782e-03 2.366 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.700203e-03 2.328 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.302782e-03 2.366 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.700203e-03 2.328 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.354880e-03 2.361 0 0
Membrane Trafficking R-HSA-199991 4.380881e-03 2.358 0 0
Host Interactions of HIV factors R-HSA-162909 4.345275e-03 2.362 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.360773e-03 2.360 0 0
mTORC1-mediated signalling R-HSA-166208 4.812556e-03 2.318 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.883491e-03 2.311 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.119627e-03 2.291 0 0
DNA Double Strand Break Response R-HSA-5693606 5.492874e-03 2.260 0 0
Regulation of PTEN localization R-HSA-8948747 5.694595e-03 2.245 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.058145e-03 2.218 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.133094e-03 2.212 0 0
PTEN Regulation R-HSA-6807070 6.340901e-03 2.198 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.897633e-03 2.161 0 0
Semaphorin interactions R-HSA-373755 7.283610e-03 2.138 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.295463e-03 2.081 0 0
Interleukin-18 signaling R-HSA-9012546 8.383983e-03 2.077 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 8.383983e-03 2.077 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.383983e-03 2.077 0 0
Formation of annular gap junctions R-HSA-196025 8.383983e-03 2.077 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.815764e-03 2.107 0 0
Aggrephagy R-HSA-9646399 7.571826e-03 2.121 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.571826e-03 2.121 0 0
S Phase R-HSA-69242 8.072980e-03 2.093 0 0
Regulation of BACH1 activity R-HSA-9708530 7.899192e-03 2.102 0 0
Negative regulation of MET activity R-HSA-6807004 7.815764e-03 2.107 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.912026e-03 2.102 0 0
Nephrin family interactions R-HSA-373753 7.815764e-03 2.107 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 8.383983e-03 2.077 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.740526e-03 2.058 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.758848e-03 2.058 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.015049e-03 2.045 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.015049e-03 2.045 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.057135e-02 1.976 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.057135e-02 1.976 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.057135e-02 1.976 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.057135e-02 1.976 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.057135e-02 1.976 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.057135e-02 1.976 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.057135e-02 1.976 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.057135e-02 1.976 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.057135e-02 1.976 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.057135e-02 1.976 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.057135e-02 1.976 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.057135e-02 1.976 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 9.864925e-03 2.006 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 9.728546e-03 2.012 0 0
MAP2K and MAPK activation R-HSA-5674135 1.025852e-02 1.989 0 0
Recycling pathway of L1 R-HSA-437239 1.018605e-02 1.992 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.821249e-03 2.008 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.458570e-03 2.024 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.864925e-03 2.006 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.000384e-02 2.000 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 9.864925e-03 2.006 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.864925e-03 2.006 0 0
G2/M Transition R-HSA-69275 1.020168e-02 1.991 0 0
ESR-mediated signaling R-HSA-8939211 1.059955e-02 1.975 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.090059e-02 1.963 0 0
Signaling by ERBB2 R-HSA-1227986 1.093137e-02 1.961 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.093137e-02 1.961 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.112088e-02 1.954 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.134416e-02 1.945 0 0
Regulation of TP53 Activity R-HSA-5633007 1.160941e-02 1.935 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.165033e-02 1.934 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.166577e-02 1.933 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.174854e-02 1.930 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.179003e-02 1.928 0 0
Gap junction degradation R-HSA-190873 1.184528e-02 1.926 0 0
Unwinding of DNA R-HSA-176974 1.184528e-02 1.926 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.184528e-02 1.926 0 0
MTOR signalling R-HSA-165159 1.185220e-02 1.926 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.196903e-02 1.922 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.202514e-02 1.920 0 0
HDACs deacetylate histones R-HSA-3214815 1.285446e-02 1.891 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.292770e-02 1.888 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.295061e-02 1.888 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.295061e-02 1.888 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.298214e-02 1.887 0 0
Maturation of protein E R-HSA-9694493 1.298214e-02 1.887 0 0
Maturation of protein E R-HSA-9683683 1.298214e-02 1.887 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.306720e-02 1.884 0 0
tRNA processing in the nucleus R-HSA-6784531 1.384003e-02 1.859 0 0
Programmed Cell Death R-HSA-5357801 1.435914e-02 1.843 0 0
Glycolysis R-HSA-70171 1.519677e-02 1.818 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.361194e-02 1.866 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.495661e-02 1.825 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.550295e-02 1.810 0 0
Ephrin signaling R-HSA-3928664 1.588294e-02 1.799 0 0
Pexophagy R-HSA-9664873 1.616732e-02 1.791 0 0
Translation R-HSA-72766 1.659562e-02 1.780 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.665569e-02 1.778 0 0
HSF1-dependent transactivation R-HSA-3371571 1.711433e-02 1.767 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.778514e-02 1.750 0 0
mRNA 3'-end processing R-HSA-72187 1.930266e-02 1.714 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.949788e-02 1.710 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.018859e-02 1.695 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.092028e-02 1.679 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.092028e-02 1.679 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.103247e-02 1.677 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.103247e-02 1.677 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.103247e-02 1.677 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.103247e-02 1.677 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.133494e-02 1.671 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.139591e-02 1.670 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.139591e-02 1.670 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.139591e-02 1.670 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.139591e-02 1.670 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.139591e-02 1.670 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.139956e-02 1.670 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.142292e-02 1.669 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.142774e-02 1.669 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.142774e-02 1.669 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.211145e-02 1.655 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.211145e-02 1.655 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.211145e-02 1.655 0 0
CHL1 interactions R-HSA-447041 2.670281e-02 1.573 0 0
Activation of RAC1 R-HSA-428540 2.769124e-02 1.558 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.769124e-02 1.558 0 0
Centrosome maturation R-HSA-380287 2.678516e-02 1.572 0 0
Signal transduction by L1 R-HSA-445144 2.365137e-02 1.626 0 0
Prolonged ERK activation events R-HSA-169893 2.612775e-02 1.583 0 0
NF-kB is activated and signals survival R-HSA-209560 2.769124e-02 1.558 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.612775e-02 1.583 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.436421e-02 1.613 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.769124e-02 1.558 0 0
Signaling by VEGF R-HSA-194138 2.801110e-02 1.553 0 0
Degradation of CDH1 R-HSA-9766229 2.884740e-02 1.540 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.888433e-02 1.539 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.019641e-02 1.520 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.034453e-02 1.518 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.115176e-02 1.507 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.115176e-02 1.507 0 0
Muscle contraction R-HSA-397014 3.259369e-02 1.487 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.500848e-02 1.456 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.500848e-02 1.456 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.500848e-02 1.456 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.500848e-02 1.456 0 0
RNA Polymerase I Transcription R-HSA-73864 3.512437e-02 1.454 0 0
G alpha (12/13) signalling events R-HSA-416482 3.512437e-02 1.454 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.590595e-02 1.445 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.590595e-02 1.445 0 0
Signal Transduction R-HSA-162582 3.630510e-02 1.440 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.754923e-02 1.425 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.795961e-02 1.421 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.841754e-02 1.415 0 0
Nucleosome assembly R-HSA-774815 3.841754e-02 1.415 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.841754e-02 1.415 0 0
Signaling by Hippo R-HSA-2028269 3.862858e-02 1.413 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.447237e-02 1.352 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.447237e-02 1.352 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.447237e-02 1.352 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.672317e-02 1.330 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.341552e-02 1.362 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.609365e-02 1.336 0 0
RAF activation R-HSA-5673000 4.314067e-02 1.365 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.585681e-02 1.339 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.991681e-02 1.399 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.419018e-02 1.355 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.419018e-02 1.355 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.841206e-02 1.315 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.672317e-02 1.330 0 0
Deubiquitination R-HSA-5688426 4.052206e-02 1.392 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.965257e-02 1.402 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.672317e-02 1.330 0 0
Orc1 removal from chromatin R-HSA-68949 3.991681e-02 1.399 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.477830e-02 1.349 0 0
DNA Repair R-HSA-73894 4.486173e-02 1.348 0 0
Neurexins and neuroligins R-HSA-6794361 3.991681e-02 1.399 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.585681e-02 1.339 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.585681e-02 1.339 0 0
Signaling by ERBB4 R-HSA-1236394 4.541054e-02 1.343 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.358778e-02 1.361 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.609365e-02 1.336 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.341552e-02 1.362 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.140956e-02 1.383 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.877596e-02 1.312 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.934938e-02 1.307 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.125210e-02 1.290 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.293370e-02 1.276 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.293370e-02 1.276 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.293370e-02 1.276 0 0
Deadenylation of mRNA R-HSA-429947 5.351125e-02 1.272 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.351125e-02 1.272 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.357781e-02 1.271 0 0
Translesion Synthesis by POLH R-HSA-110320 5.439550e-02 1.264 0 0
Regulation of signaling by CBL R-HSA-912631 5.439550e-02 1.264 0 0
STING mediated induction of host immune responses R-HSA-1834941 5.439550e-02 1.264 0 0
HSF1 activation R-HSA-3371511 5.487686e-02 1.261 0 0
FLT3 signaling in disease R-HSA-9682385 5.487686e-02 1.261 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.618846e-02 1.250 0 0
Autophagy R-HSA-9612973 5.738907e-02 1.241 0 0
DNA Damage Bypass R-HSA-73893 5.830783e-02 1.234 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.837332e-02 1.234 0 0
EGFR downregulation R-HSA-182971 5.837332e-02 1.234 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.837332e-02 1.234 0 0
Selenoamino acid metabolism R-HSA-2408522 5.846611e-02 1.233 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.888008e-02 1.230 0 0
Signaling by EGFR R-HSA-177929 5.888008e-02 1.230 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 5.888008e-02 1.230 0 0
Signaling by PTK6 R-HSA-8848021 5.894369e-02 1.230 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.894369e-02 1.230 0 0
2-LTR circle formation R-HSA-164843 5.915186e-02 1.228 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.915186e-02 1.228 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.915186e-02 1.228 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 5.915186e-02 1.228 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.130013e-02 1.213 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.130013e-02 1.213 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.130013e-02 1.213 0 0
HDMs demethylate histones R-HSA-3214842 6.144696e-02 1.211 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.145261e-02 1.211 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.145261e-02 1.211 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 7.409846e-02 1.130 0 0
Diseases of Cellular Senescence R-HSA-9630747 7.409846e-02 1.130 0 0
Diseases of cellular response to stress R-HSA-9675132 7.409846e-02 1.130 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.531732e-02 1.123 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.354394e-02 1.133 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.587230e-02 1.181 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.703385e-02 1.113 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.029737e-02 1.153 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.402807e-02 1.076 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.402807e-02 1.076 0 0
Cyclin D associated events in G1 R-HSA-69231 6.990468e-02 1.155 0 0
G1 Phase R-HSA-69236 6.990468e-02 1.155 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.283129e-02 1.138 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.006439e-02 1.155 0 0
G0 and Early G1 R-HSA-1538133 6.587230e-02 1.181 0 0
Metalloprotease DUBs R-HSA-5689901 7.006439e-02 1.155 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.008162e-02 1.096 0 0
Homology Directed Repair R-HSA-5693538 7.014067e-02 1.154 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.356993e-02 1.197 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.691367e-02 1.114 0 0
Neurofascin interactions R-HSA-447043 8.063875e-02 1.093 0 0
Selective autophagy R-HSA-9663891 8.171947e-02 1.088 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.613152e-02 1.180 0 0
Stabilization of p53 R-HSA-69541 7.605444e-02 1.119 0 0
Glycogen synthesis R-HSA-3322077 6.354468e-02 1.197 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.326917e-02 1.199 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.393993e-02 1.131 0 0
p75NTR signals via NF-kB R-HSA-193639 6.356993e-02 1.197 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.354394e-02 1.133 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.587230e-02 1.181 0 0
G1/S Transition R-HSA-69206 7.193077e-02 1.143 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.316001e-02 1.136 0 0
Basigin interactions R-HSA-210991 7.354394e-02 1.133 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.393993e-02 1.131 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.356993e-02 1.197 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.356993e-02 1.197 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.605444e-02 1.119 0 0
Glucose metabolism R-HSA-70326 6.605525e-02 1.180 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.356993e-02 1.197 0 0
IRE1alpha activates chaperones R-HSA-381070 6.484462e-02 1.188 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.356993e-02 1.197 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.249457e-02 1.140 0 0
Attenuation phase R-HSA-3371568 8.408765e-02 1.075 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.408765e-02 1.075 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.408765e-02 1.075 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.408765e-02 1.075 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 8.438851e-02 1.074 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.438851e-02 1.074 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.438851e-02 1.074 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.438851e-02 1.074 0 0
Assembly Of The HIV Virion R-HSA-175474 8.438851e-02 1.074 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.438851e-02 1.074 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.445128e-02 1.073 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.445128e-02 1.073 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.815605e-02 1.055 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.815605e-02 1.055 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.815605e-02 1.055 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.815763e-02 1.055 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.869014e-02 1.052 0 0
Integration of provirus R-HSA-162592 8.869014e-02 1.052 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.869014e-02 1.052 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.994716e-02 1.046 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.178653e-02 1.037 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.236582e-02 1.034 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.260990e-02 1.033 0 0
Potential therapeutics for SARS R-HSA-9679191 9.311287e-02 1.031 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.606631e-02 1.017 0 0
Heme signaling R-HSA-9707616 9.717828e-02 1.012 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.915521e-02 1.004 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.000043e-01 1.000 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.007072e-01 0.997 0 0
Regulation of Apoptosis R-HSA-169911 1.015602e-01 0.993 0 0
Signalling to ERKs R-HSA-187687 1.015602e-01 0.993 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.019402e-01 0.992 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.020545e-01 0.991 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.020545e-01 0.991 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.020545e-01 0.991 0 0
Glycogen storage diseases R-HSA-3229121 1.020545e-01 0.991 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.022526e-01 0.990 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.022526e-01 0.990 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.022526e-01 0.990 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.022526e-01 0.990 0 0
Interleukin-1 family signaling R-HSA-446652 1.024564e-01 0.989 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.026443e-01 0.989 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.026443e-01 0.989 0 0
Signaling by Interleukins R-HSA-449147 1.034707e-01 0.985 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.053737e-01 0.977 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.053737e-01 0.977 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.053737e-01 0.977 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.053737e-01 0.977 0 0
Repression of WNT target genes R-HSA-4641265 1.056632e-01 0.976 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.056632e-01 0.976 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.056632e-01 0.976 0 0
Inositol phosphate metabolism R-HSA-1483249 1.060965e-01 0.974 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.072868e-01 0.969 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.072868e-01 0.969 0 0
NRAGE signals death through JNK R-HSA-193648 1.072868e-01 0.969 0 0
MET interacts with TNS proteins R-HSA-8875513 1.078468e-01 0.967 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.078468e-01 0.967 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.085584e-01 0.964 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.085584e-01 0.964 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.085584e-01 0.964 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.093776e-01 0.961 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.093776e-01 0.961 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.093776e-01 0.961 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.110676e-01 0.954 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.111101e-01 0.954 0 0
Ca-dependent events R-HSA-111996 1.111101e-01 0.954 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.111101e-01 0.954 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.113225e-01 0.953 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.113225e-01 0.953 0 0
Activation of BH3-only proteins R-HSA-114452 1.113225e-01 0.953 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.118918e-01 0.951 0 0
RNA Polymerase III Transcription R-HSA-74158 1.118918e-01 0.951 0 0
Calmodulin induced events R-HSA-111933 1.118918e-01 0.951 0 0
CaM pathway R-HSA-111997 1.118918e-01 0.951 0 0
Gene expression (Transcription) R-HSA-74160 1.130763e-01 0.947 0 0
Apoptotic factor-mediated response R-HSA-111471 1.169702e-01 0.932 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.169702e-01 0.932 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.447656e-01 0.839 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.447656e-01 0.839 0 0
Type I hemidesmosome assembly R-HSA-446107 1.258772e-01 0.900 0 0
ARMS-mediated activation R-HSA-170984 1.512335e-01 0.820 0 0
Calcineurin activates NFAT R-HSA-2025928 1.512335e-01 0.820 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.642102e-01 0.785 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.218395e-01 0.914 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.496393e-01 0.825 0 0
Degradation of AXIN R-HSA-4641257 1.227710e-01 0.911 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.660794e-01 0.780 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.660794e-01 0.780 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.461161e-01 0.835 0 0
Dual incision in TC-NER R-HSA-6782135 1.246724e-01 0.904 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.382617e-01 0.859 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.294904e-01 0.888 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.670330e-01 0.777 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.649181e-01 0.783 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.762035e-01 0.754 0 0
G-protein beta:gamma signalling R-HSA-397795 1.490696e-01 0.827 0 0
Ub-specific processing proteases R-HSA-5689880 1.338172e-01 0.873 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.672665e-01 0.777 0 0
Nucleotide Excision Repair R-HSA-5696398 1.657012e-01 0.781 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.670330e-01 0.777 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.374372e-01 0.862 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.419546e-01 0.848 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.423972e-01 0.846 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.315093e-01 0.881 0 0
Frs2-mediated activation R-HSA-170968 1.239828e-01 0.907 0 0
DCC mediated attractive signaling R-HSA-418885 1.642102e-01 0.785 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.642102e-01 0.785 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.714566e-01 0.766 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.315093e-01 0.881 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.435386e-01 0.843 0 0
Translesion synthesis by REV1 R-HSA-110312 1.642102e-01 0.785 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.339169e-01 0.873 0 0
Myogenesis R-HSA-525793 1.506387e-01 0.822 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.358784e-01 0.867 0 0
Budding and maturation of HIV virion R-HSA-162588 1.232868e-01 0.909 0 0
Trafficking of AMPA receptors R-HSA-399719 1.232868e-01 0.909 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.280734e-01 0.893 0 0
Degradation of DVL R-HSA-4641258 1.227710e-01 0.911 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.714566e-01 0.766 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.714566e-01 0.766 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.628371e-01 0.788 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.206863e-01 0.918 0 0
Vesicle-mediated transport R-HSA-5653656 1.626750e-01 0.789 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.206863e-01 0.918 0 0
Macroautophagy R-HSA-1632852 1.220475e-01 0.913 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.496393e-01 0.825 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.256147e-01 0.901 0 0
Cellular response to hypoxia R-HSA-1234174 1.209095e-01 0.918 0 0
Cellular response to chemical stress R-HSA-9711123 1.658091e-01 0.780 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.670330e-01 0.777 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.620572e-01 0.790 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.190282e-01 0.924 0 0
Signaling by MET R-HSA-6806834 1.206863e-01 0.918 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.771496e-01 0.752 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.585471e-01 0.800 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.594495e-01 0.797 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.637728e-01 0.786 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.637728e-01 0.786 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.670330e-01 0.777 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.537270e-01 0.813 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.585471e-01 0.800 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.490696e-01 0.827 0 0
Synthesis of DNA R-HSA-69239 1.229901e-01 0.910 0 0
Developmental Biology R-HSA-1266738 1.673015e-01 0.777 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.628371e-01 0.788 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.771496e-01 0.752 0 0
RMTs methylate histone arginines R-HSA-3214858 1.315093e-01 0.881 0 0
DAG and IP3 signaling R-HSA-1489509 1.423972e-01 0.846 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.642102e-01 0.785 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.490696e-01 0.827 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.660794e-01 0.780 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.672665e-01 0.777 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.771868e-01 0.752 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.780382e-01 0.749 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.780382e-01 0.749 0 0
Formation of apoptosome R-HSA-111458 1.780382e-01 0.749 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.780382e-01 0.749 0 0
Sensory processing of sound R-HSA-9659379 1.791947e-01 0.747 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.805923e-01 0.743 0 0
Chromosome Maintenance R-HSA-73886 1.818825e-01 0.740 0 0
HIV elongation arrest and recovery R-HSA-167287 1.821554e-01 0.740 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.821554e-01 0.740 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.821554e-01 0.740 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.821554e-01 0.740 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.838128e-01 0.736 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.838128e-01 0.736 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 1.838128e-01 0.736 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.848213e-01 0.733 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.848213e-01 0.733 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.856617e-01 0.731 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.856617e-01 0.731 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.856617e-01 0.731 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.858701e-01 0.731 0 0
Translesion synthesis by POLI R-HSA-5656121 1.858701e-01 0.731 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.858701e-01 0.731 0 0
Negative regulation of FLT3 R-HSA-9706369 1.858701e-01 0.731 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.876299e-01 0.727 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.876299e-01 0.727 0 0
Post NMDA receptor activation events R-HSA-438064 1.901736e-01 0.721 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.902092e-01 0.721 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.902092e-01 0.721 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.902092e-01 0.721 0 0
Interleukin-1 signaling R-HSA-9020702 1.908945e-01 0.719 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.919742e-01 0.717 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.919742e-01 0.717 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.996493e-01 0.700 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.996493e-01 0.700 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.996493e-01 0.700 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.996493e-01 0.700 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.996493e-01 0.700 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 1.996493e-01 0.700 0 0
Hereditary fructose intolerance R-HSA-5657560 1.996493e-01 0.700 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.996493e-01 0.700 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.996493e-01 0.700 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.839951e-01 0.547 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.839951e-01 0.547 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.839951e-01 0.547 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.839951e-01 0.547 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.839951e-01 0.547 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.839951e-01 0.547 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.839951e-01 0.547 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.839951e-01 0.547 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.839951e-01 0.547 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.839951e-01 0.547 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.241306e-01 0.649 0 0
PKB-mediated events R-HSA-109703 2.241306e-01 0.649 0 0
PDE3B signalling R-HSA-165160 2.241306e-01 0.649 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.241306e-01 0.649 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.594565e-01 0.444 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.594565e-01 0.444 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.594565e-01 0.444 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.594565e-01 0.444 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.594565e-01 0.444 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.594565e-01 0.444 0 0
Signaling by LTK in cancer R-HSA-9842640 2.650181e-01 0.577 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.650181e-01 0.577 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.348876e-01 0.629 0 0
SOS-mediated signalling R-HSA-112412 3.059079e-01 0.514 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.059079e-01 0.514 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.083871e-01 0.681 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.083871e-01 0.681 0 0
Translesion synthesis by POLK R-HSA-5655862 2.083871e-01 0.681 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.083871e-01 0.681 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.644095e-01 0.578 0 0
GRB2 events in EGFR signaling R-HSA-179812 2.644095e-01 0.578 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.316281e-01 0.635 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.463458e-01 0.460 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.463458e-01 0.460 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.463458e-01 0.460 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.047493e-01 0.689 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.943417e-01 0.531 0 0
PKA activation R-HSA-163615 2.554610e-01 0.593 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.554610e-01 0.593 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.554610e-01 0.593 0 0
Activation of the pre-replicative complex R-HSA-68962 2.160170e-01 0.666 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.160170e-01 0.666 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.797562e-01 0.553 0 0
Retrograde neurotrophin signalling R-HSA-177504 3.244672e-01 0.489 0 0
Lipophagy R-HSA-9613354 3.859731e-01 0.413 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.859731e-01 0.413 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.336984e-01 0.631 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.545892e-01 0.450 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 3.545892e-01 0.450 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.556618e-01 0.592 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.077806e-01 0.512 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.077806e-01 0.512 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.845316e-01 0.415 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.845316e-01 0.415 0 0
Phosphorylation of the APC/C R-HSA-176412 3.845316e-01 0.415 0 0
HIV Transcription Elongation R-HSA-167169 2.724850e-01 0.565 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.724850e-01 0.565 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.724850e-01 0.565 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.439425e-01 0.613 0 0
Meiotic synapsis R-HSA-1221632 2.439425e-01 0.613 0 0
Dual Incision in GG-NER R-HSA-5696400 3.081461e-01 0.511 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.510469e-01 0.455 0 0
Notch-HLH transcription pathway R-HSA-350054 3.791363e-01 0.421 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.791363e-01 0.421 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.468240e-01 0.460 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.728148e-01 0.429 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.541235e-01 0.595 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.564732e-01 0.448 0 0
Neutrophil degranulation R-HSA-6798695 3.180436e-01 0.498 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.053144e-01 0.515 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.310115e-01 0.480 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.835732e-01 0.416 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.315962e-01 0.635 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.724850e-01 0.565 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.730526e-01 0.564 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.202962e-01 0.657 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.988183e-01 0.702 0 0
Integrin signaling R-HSA-354192 2.702895e-01 0.568 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.702895e-01 0.568 0 0
PERK regulates gene expression R-HSA-381042 3.274097e-01 0.485 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.778254e-01 0.423 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.047493e-01 0.689 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.859731e-01 0.413 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.423047e-01 0.616 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.209753e-01 0.494 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.423047e-01 0.616 0 0
DAP12 signaling R-HSA-2424491 3.728148e-01 0.429 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.059079e-01 0.514 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.083871e-01 0.681 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.372998e-01 0.472 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.946459e-01 0.711 0 0
UCH proteinases R-HSA-5689603 2.320737e-01 0.634 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.644095e-01 0.578 0 0
Long-term potentiation R-HSA-9620244 2.653720e-01 0.576 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.556618e-01 0.592 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.996493e-01 0.700 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 2.348876e-01 0.629 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.083871e-01 0.681 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.463458e-01 0.460 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.463458e-01 0.460 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.988183e-01 0.702 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.890876e-01 0.539 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.728148e-01 0.429 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.995357e-01 0.700 0 0
Signaling by WNT R-HSA-195721 3.524383e-01 0.453 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.510469e-01 0.455 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.702895e-01 0.568 0 0
Developmental Cell Lineages R-HSA-9734767 3.510049e-01 0.455 0 0
Platelet calcium homeostasis R-HSA-418360 3.510469e-01 0.455 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.468240e-01 0.460 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.864304e-01 0.543 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.845316e-01 0.415 0 0
Aquaporin-mediated transport R-HSA-445717 3.631831e-01 0.440 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.730526e-01 0.564 0 0
Ion homeostasis R-HSA-5578775 2.872634e-01 0.542 0 0
G-protein mediated events R-HSA-112040 3.275650e-01 0.485 0 0
PCP/CE pathway R-HSA-4086400 2.557233e-01 0.592 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.275650e-01 0.485 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.783099e-01 0.422 0 0
Circadian clock R-HSA-9909396 2.218110e-01 0.654 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.554610e-01 0.593 0 0
Rap1 signalling R-HSA-392517 2.797562e-01 0.553 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.545892e-01 0.450 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.545892e-01 0.450 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.128140e-01 0.672 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.292368e-01 0.482 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.423047e-01 0.616 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.077334e-01 0.512 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.960231e-01 0.708 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.797562e-01 0.553 0 0
Signaling by FGFR4 R-HSA-5654743 2.128140e-01 0.672 0 0
Ion transport by P-type ATPases R-HSA-936837 2.851994e-01 0.545 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.992015e-01 0.701 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.069258e-01 0.513 0 0
Signaling by FGFR3 R-HSA-5654741 2.423047e-01 0.616 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.996493e-01 0.700 0 0
Inhibition of PKR R-HSA-169131 1.996493e-01 0.700 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.839951e-01 0.547 0 0
Interleukin-33 signaling R-HSA-9014843 3.594565e-01 0.444 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.594565e-01 0.444 0 0
Antagonism of Activin by Follistatin R-HSA-2473224 3.594565e-01 0.444 0 0
Bicarbonate transporters R-HSA-425381 2.060125e-01 0.686 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 2.644095e-01 0.578 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.554610e-01 0.593 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.988183e-01 0.702 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.072756e-01 0.683 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.230167e-01 0.652 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.423047e-01 0.616 0 0
Kinesins R-HSA-983189 2.314823e-01 0.635 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.081461e-01 0.511 0 0
Interferon Signaling R-HSA-913531 2.435686e-01 0.613 0 0
PLC beta mediated events R-HSA-112043 2.445514e-01 0.612 0 0
Signaling by FGFR4 in disease R-HSA-5655291 3.244672e-01 0.489 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.702895e-01 0.568 0 0
DNA Replication R-HSA-69306 3.558555e-01 0.449 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.980675e-01 0.703 0 0
Platelet degranulation R-HSA-114608 3.226395e-01 0.491 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.797562e-01 0.553 0 0
Downstream signal transduction R-HSA-186763 2.336984e-01 0.631 0 0
Hedgehog 'off' state R-HSA-5610787 2.608755e-01 0.584 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.859731e-01 0.413 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.702895e-01 0.568 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.077806e-01 0.512 0 0
Iron uptake and transport R-HSA-917937 3.227870e-01 0.491 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.824921e-01 0.549 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.298993e-01 0.482 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.702895e-01 0.568 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.656698e-01 0.576 0 0
Interleukin-1 processing R-HSA-448706 3.859731e-01 0.413 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.164203e-01 0.665 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.077806e-01 0.512 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.069258e-01 0.513 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.069258e-01 0.513 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.372998e-01 0.472 0 0
Mitophagy R-HSA-5205647 3.081461e-01 0.511 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.329833e-01 0.478 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.631831e-01 0.440 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.241306e-01 0.649 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.650181e-01 0.577 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.797562e-01 0.553 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.859731e-01 0.413 0 0
Protein methylation R-HSA-8876725 3.545892e-01 0.450 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.292368e-01 0.482 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.292368e-01 0.482 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.845316e-01 0.415 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 2.314823e-01 0.635 0 0
Death Receptor Signaling R-HSA-73887 2.856665e-01 0.544 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.858942e-01 0.414 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.463458e-01 0.460 0 0
Hedgehog 'on' state R-HSA-5632684 2.698071e-01 0.569 0 0
Signaling by PDGF R-HSA-186797 3.786887e-01 0.422 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.463458e-01 0.460 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.864304e-01 0.543 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.702895e-01 0.568 0 0
Signaling by ALK R-HSA-201556 2.556618e-01 0.592 0 0
Neurodegenerative Diseases R-HSA-8863678 2.446851e-01 0.611 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.446851e-01 0.611 0 0
DNA strand elongation R-HSA-69190 2.518078e-01 0.599 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.069258e-01 0.513 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.594565e-01 0.444 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.059079e-01 0.514 0 0
Sodium/Proton exchangers R-HSA-425986 3.463458e-01 0.460 0 0
Signaling by NOTCH4 R-HSA-9013694 3.093080e-01 0.510 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.205861e-01 0.656 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.091412e-01 0.680 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.077806e-01 0.512 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.059079e-01 0.514 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.083871e-01 0.681 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.463458e-01 0.460 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.859731e-01 0.413 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.541884e-01 0.451 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.322761e-01 0.479 0 0
FOXO-mediated transcription R-HSA-9614085 3.446190e-01 0.463 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.778254e-01 0.423 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.778254e-01 0.423 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.864304e-01 0.543 0 0
Gene Silencing by RNA R-HSA-211000 2.583383e-01 0.588 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.421484e-01 0.466 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.943417e-01 0.531 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.859731e-01 0.413 0 0
SARS-CoV Infections R-HSA-9679506 2.071440e-01 0.684 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 3.244672e-01 0.489 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.541884e-01 0.451 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.944465e-01 0.711 0 0
FLT3 Signaling R-HSA-9607240 2.895869e-01 0.538 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.443049e-01 0.463 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.942412e-01 0.404 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.945793e-01 0.404 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.957353e-01 0.403 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.957353e-01 0.403 0 0
Diseases of programmed cell death R-HSA-9645723 3.968636e-01 0.401 0 0
Co-inhibition by PD-1 R-HSA-389948 3.979389e-01 0.400 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.979389e-01 0.400 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.994964e-01 0.398 0 0
Signaling by NOTCH3 R-HSA-9012852 4.034925e-01 0.394 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.039816e-01 0.394 1 1
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.039816e-01 0.394 0 0
Syndecan interactions R-HSA-3000170 4.039816e-01 0.394 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.054493e-01 0.392 0 0
ER-Phagosome pathway R-HSA-1236974 4.101823e-01 0.387 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.136423e-01 0.383 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.141391e-01 0.383 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.141391e-01 0.383 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.141391e-01 0.383 0 0
Disorders of Developmental Biology R-HSA-9675151 4.141391e-01 0.383 0 0
Passive transport by Aquaporins R-HSA-432047 4.141391e-01 0.383 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.141659e-01 0.383 0 0
Signaling by FGFR1 R-HSA-5654736 4.201094e-01 0.377 0 0
Regulation of CDH11 function R-HSA-9762292 4.245117e-01 0.372 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.245117e-01 0.372 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.245117e-01 0.372 0 0
Signaling by TGFB family members R-HSA-9006936 4.247901e-01 0.372 0 0
Glycogen metabolism R-HSA-8982491 4.249538e-01 0.372 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.269687e-01 0.370 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.269687e-01 0.370 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.269687e-01 0.370 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.269687e-01 0.370 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 4.269687e-01 0.370 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.269687e-01 0.370 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.269687e-01 0.370 0 0
Intracellular oxygen transport R-HSA-8981607 4.269687e-01 0.370 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.269687e-01 0.370 0 0
Histamine receptors R-HSA-390650 4.269687e-01 0.370 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.269687e-01 0.370 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.286331e-01 0.368 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.286331e-01 0.368 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.286331e-01 0.368 0 0
GPER1 signaling R-HSA-9634597 4.315099e-01 0.365 0 0
NGF-stimulated transcription R-HSA-9031628 4.315099e-01 0.365 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.330745e-01 0.363 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.354033e-01 0.361 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.368434e-01 0.360 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.397155e-01 0.357 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.397155e-01 0.357 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.397155e-01 0.357 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.432760e-01 0.353 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 4.432760e-01 0.353 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.493036e-01 0.347 0 0
MAPK family signaling cascades R-HSA-5683057 4.500288e-01 0.347 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.530081e-01 0.344 0 0
Interleukin-7 signaling R-HSA-1266695 4.530081e-01 0.344 0 0
MHC class II antigen presentation R-HSA-2132295 4.580584e-01 0.339 0 0
Signaling by NOTCH1 R-HSA-1980143 4.591223e-01 0.338 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.592184e-01 0.338 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.592184e-01 0.338 0 0
Signaling by Hedgehog R-HSA-5358351 4.609784e-01 0.336 0 0
Meiosis R-HSA-1500620 4.614294e-01 0.336 0 0
PECAM1 interactions R-HSA-210990 4.617510e-01 0.336 0 0
Formation of the posterior neural plate R-HSA-9832991 4.617510e-01 0.336 0 0
Chylomicron assembly R-HSA-8963888 4.617510e-01 0.336 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.617510e-01 0.336 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.617510e-01 0.336 0 0
Protein folding R-HSA-391251 4.634361e-01 0.334 0 0
Viral Infection Pathways R-HSA-9824446 4.700961e-01 0.328 0 0
Adipogenesis R-HSA-9843745 4.706473e-01 0.327 0 0
PKA activation in glucagon signalling R-HSA-164378 4.718254e-01 0.326 0 0
Polo-like kinase mediated events R-HSA-156711 4.718254e-01 0.326 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.718254e-01 0.326 0 0
Tie2 Signaling R-HSA-210993 4.718254e-01 0.326 0 0
Transcription of the HIV genome R-HSA-167172 4.718523e-01 0.326 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.770318e-01 0.321 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.770318e-01 0.321 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.803563e-01 0.318 0 0
Signaling by NOTCH2 R-HSA-1980145 4.803563e-01 0.318 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.803563e-01 0.318 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.803563e-01 0.318 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.803563e-01 0.318 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.803563e-01 0.318 0 0
Calnexin/calreticulin cycle R-HSA-901042 4.803563e-01 0.318 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.827277e-01 0.316 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.873689e-01 0.312 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.873689e-01 0.312 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.873689e-01 0.312 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.873689e-01 0.312 0 0
Alanine metabolism R-HSA-8964540 4.873689e-01 0.312 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.873689e-01 0.312 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.873689e-01 0.312 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.873689e-01 0.312 0 0
NADE modulates death signalling R-HSA-205025 4.873689e-01 0.312 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.873689e-01 0.312 0 0
Dopamine receptors R-HSA-390651 4.873689e-01 0.312 0 0
TCR signaling R-HSA-202403 4.911470e-01 0.309 0 0
Rab regulation of trafficking R-HSA-9007101 4.917060e-01 0.308 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.975369e-01 0.303 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.975369e-01 0.303 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.975369e-01 0.303 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.975369e-01 0.303 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.975369e-01 0.303 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.975369e-01 0.303 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.996888e-01 0.301 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.996888e-01 0.301 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 4.996888e-01 0.301 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 4.996888e-01 0.301 0 0
The NLRP3 inflammasome R-HSA-844456 4.996888e-01 0.301 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 4.996888e-01 0.301 0 0
Cristae formation R-HSA-8949613 5.006375e-01 0.300 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.006375e-01 0.300 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.006375e-01 0.300 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.012056e-01 0.300 0 0
TBC/RABGAPs R-HSA-8854214 5.016065e-01 0.300 0 0
Defective pyroptosis R-HSA-9710421 5.016065e-01 0.300 0 0
Pyruvate metabolism R-HSA-70268 5.027811e-01 0.299 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.033882e-01 0.298 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.150091e-01 0.288 0 0
Opioid Signalling R-HSA-111885 5.155996e-01 0.288 0 0
PKR-mediated signaling R-HSA-9833482 5.168896e-01 0.287 0 0
Signaling by FGFR2 R-HSA-5654738 5.168896e-01 0.287 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.182097e-01 0.285 0 0
Gap junction trafficking R-HSA-190828 5.202363e-01 0.284 0 0
RET signaling R-HSA-8853659 5.217223e-01 0.283 0 0
G1/S-Specific Transcription R-HSA-69205 5.217223e-01 0.283 0 0
HCMV Early Events R-HSA-9609690 5.227346e-01 0.282 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.237667e-01 0.281 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.237667e-01 0.281 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.237667e-01 0.281 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.237667e-01 0.281 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.267839e-01 0.278 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.267839e-01 0.278 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.267839e-01 0.278 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.267839e-01 0.278 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.267839e-01 0.278 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.267839e-01 0.278 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.267839e-01 0.278 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.288826e-01 0.277 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.317620e-01 0.274 0 0
MET activates RAS signaling R-HSA-8851805 5.317620e-01 0.274 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.317620e-01 0.274 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.317620e-01 0.274 0 0
Disorders of Nervous System Development R-HSA-9697154 5.317620e-01 0.274 0 0
Pervasive developmental disorders R-HSA-9005895 5.317620e-01 0.274 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.317620e-01 0.274 0 0
Signaling by LTK R-HSA-9842663 5.317620e-01 0.274 0 0
OAS antiviral response R-HSA-8983711 5.317620e-01 0.274 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.385856e-01 0.269 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.414057e-01 0.266 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.414057e-01 0.266 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.414057e-01 0.266 0 0
Defective F9 activation R-HSA-9673221 5.414057e-01 0.266 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.414057e-01 0.266 0 0
Activation of AKT2 R-HSA-165158 5.414057e-01 0.266 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.414057e-01 0.266 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.414057e-01 0.266 0 0
PTK6 Down-Regulation R-HSA-8849472 5.414057e-01 0.266 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.414057e-01 0.266 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.414057e-01 0.266 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.414057e-01 0.266 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.414057e-01 0.266 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.414057e-01 0.266 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.414057e-01 0.266 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.414057e-01 0.266 0 0
Inositol transporters R-HSA-429593 5.414057e-01 0.266 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.414057e-01 0.266 0 0
Interleukin-36 pathway R-HSA-9014826 5.414057e-01 0.266 0 0
NrCAM interactions R-HSA-447038 5.414057e-01 0.266 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.414057e-01 0.266 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.463681e-01 0.263 0 0
Ca2+ pathway R-HSA-4086398 5.471864e-01 0.262 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.497119e-01 0.260 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.512397e-01 0.259 0 0
G-protein activation R-HSA-202040 5.530440e-01 0.257 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.530440e-01 0.257 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.530440e-01 0.257 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.530440e-01 0.257 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.589248e-01 0.253 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.616048e-01 0.251 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.616048e-01 0.251 0 0
Signaling by FGFR in disease R-HSA-1226099 5.617676e-01 0.250 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.643579e-01 0.248 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.643579e-01 0.248 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.643579e-01 0.248 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.643579e-01 0.248 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.643579e-01 0.248 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.643579e-01 0.248 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.664223e-01 0.247 0 0
HATs acetylate histones R-HSA-3214847 5.669347e-01 0.246 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.683982e-01 0.245 0 0
Interleukin-37 signaling R-HSA-9008059 5.683982e-01 0.245 0 0
TNF signaling R-HSA-75893 5.692357e-01 0.245 0 0
RNA Polymerase II Transcription R-HSA-73857 5.708152e-01 0.244 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.716821e-01 0.243 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.765725e-01 0.239 0 0
Signaling by NTRKs R-HSA-166520 5.766017e-01 0.239 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.784163e-01 0.238 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.806433e-01 0.236 0 0
RAS processing R-HSA-9648002 5.809043e-01 0.236 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.883978e-01 0.230 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.897494e-01 0.229 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.897494e-01 0.229 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.897494e-01 0.229 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.897494e-01 0.229 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.897494e-01 0.229 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.897494e-01 0.229 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.897494e-01 0.229 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.897494e-01 0.229 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.897494e-01 0.229 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.897494e-01 0.229 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.897494e-01 0.229 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.897494e-01 0.229 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.897494e-01 0.229 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.898200e-01 0.229 0 0
Co-stimulation by CD28 R-HSA-389356 5.916778e-01 0.228 0 0
Regulation of KIT signaling R-HSA-1433559 5.952876e-01 0.225 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.952876e-01 0.225 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.952876e-01 0.225 0 0
Signal regulatory protein family interactions R-HSA-391160 5.952876e-01 0.225 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.994221e-01 0.222 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.028611e-01 0.220 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.028611e-01 0.220 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.028611e-01 0.220 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.028611e-01 0.220 0 0
LDL clearance R-HSA-8964038 6.028611e-01 0.220 0 0
Signaling by KIT in disease R-HSA-9669938 6.028611e-01 0.220 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.031981e-01 0.220 0 0
Gap junction trafficking and regulation R-HSA-157858 6.086461e-01 0.216 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.099550e-01 0.215 0 0
Regulated Necrosis R-HSA-5218859 6.099550e-01 0.215 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 6.180856e-01 0.209 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.190269e-01 0.208 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.190269e-01 0.208 0 0
tRNA processing R-HSA-72306 6.203849e-01 0.207 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.245403e-01 0.204 0 0
Erythropoietin activates RAS R-HSA-9027284 6.245403e-01 0.204 0 0
Formation of the anterior neural plate R-HSA-9823739 6.245403e-01 0.204 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.263496e-01 0.203 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.263496e-01 0.203 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.263496e-01 0.203 0 0
Nuclear RNA decay R-HSA-9930044 6.307241e-01 0.200 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.307241e-01 0.200 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.307241e-01 0.200 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.319995e-01 0.199 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.319995e-01 0.199 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.319995e-01 0.199 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.319995e-01 0.199 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.319995e-01 0.199 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.329993e-01 0.199 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.329993e-01 0.199 0 0
Chylomicron clearance R-HSA-8964026 6.329993e-01 0.199 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.329993e-01 0.199 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.329993e-01 0.199 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.329993e-01 0.199 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.329993e-01 0.199 0 0
Lactose synthesis R-HSA-5653890 6.329993e-01 0.199 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.329993e-01 0.199 0 0
VLDL assembly R-HSA-8866423 6.329993e-01 0.199 0 0
Nef and signal transduction R-HSA-164944 6.329993e-01 0.199 0 0
HDL clearance R-HSA-8964011 6.329993e-01 0.199 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.329993e-01 0.199 0 0
Cilium Assembly R-HSA-5617833 6.330111e-01 0.199 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.341903e-01 0.198 0 0
Translation of Structural Proteins R-HSA-9683701 6.359254e-01 0.197 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.443683e-01 0.191 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.468545e-01 0.189 0 0
MAP kinase activation R-HSA-450294 6.468545e-01 0.189 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.488637e-01 0.188 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.488637e-01 0.188 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.488637e-01 0.188 0 0
Complex III assembly R-HSA-9865881 6.488637e-01 0.188 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.488637e-01 0.188 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.501347e-01 0.187 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.501640e-01 0.187 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.503622e-01 0.187 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.511760e-01 0.186 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.511760e-01 0.186 0 0
Killing mechanisms R-HSA-9664420 6.521257e-01 0.186 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.521257e-01 0.186 0 0
Activation of SMO R-HSA-5635838 6.521257e-01 0.186 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.521257e-01 0.186 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.571137e-01 0.182 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.571137e-01 0.182 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.575360e-01 0.182 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.613510e-01 0.180 0 0
Downstream TCR signaling R-HSA-202424 6.626791e-01 0.179 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.667624e-01 0.176 0 0
Signaling by NOTCH R-HSA-157118 6.681585e-01 0.175 0 0
SLC transporter disorders R-HSA-5619102 6.686998e-01 0.175 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.687883e-01 0.175 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.689097e-01 0.175 0 0
Signal amplification R-HSA-392518 6.689097e-01 0.175 0 0
Signaling by SCF-KIT R-HSA-1433557 6.700248e-01 0.174 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.703940e-01 0.174 0 0
Tight junction interactions R-HSA-420029 6.703940e-01 0.174 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.703940e-01 0.174 0 0
G protein gated Potassium channels R-HSA-1296059 6.703940e-01 0.174 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.703940e-01 0.174 0 0
TGFBR3 expression R-HSA-9839394 6.703940e-01 0.174 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.703940e-01 0.174 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.716920e-01 0.173 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.716920e-01 0.173 0 0
Recycling of eIF2:GDP R-HSA-72731 6.716920e-01 0.173 0 0
Disinhibition of SNARE formation R-HSA-114516 6.716920e-01 0.173 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.716920e-01 0.173 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.716920e-01 0.173 0 0
PTK6 Expression R-HSA-8849473 6.716920e-01 0.173 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.716920e-01 0.173 0 0
Reuptake of GABA R-HSA-888593 6.716920e-01 0.173 0 0
LDL remodeling R-HSA-8964041 6.716920e-01 0.173 0 0
VLDL clearance R-HSA-8964046 6.716920e-01 0.173 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.716920e-01 0.173 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.716920e-01 0.173 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.719015e-01 0.173 0 0
Parasite infection R-HSA-9664407 6.719015e-01 0.173 0 0
Leishmania phagocytosis R-HSA-9664417 6.719015e-01 0.173 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.780703e-01 0.169 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.780703e-01 0.169 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.780703e-01 0.169 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.780703e-01 0.169 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.833138e-01 0.165 0 0
Proteasome assembly R-HSA-9907900 6.862632e-01 0.164 0 0
DAP12 interactions R-HSA-2172127 6.862632e-01 0.164 0 0
Netrin-1 signaling R-HSA-373752 6.862632e-01 0.164 0 0
IGF1R signaling cascade R-HSA-2428924 6.892342e-01 0.162 0 0
ABC-family proteins mediated transport R-HSA-382556 6.900898e-01 0.161 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.909392e-01 0.161 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.909392e-01 0.161 0 0
Mitochondrial biogenesis R-HSA-1592230 6.976540e-01 0.156 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.977300e-01 0.156 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.999916e-01 0.155 0 0
G alpha (z) signalling events R-HSA-418597 7.016776e-01 0.154 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.024133e-01 0.153 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.024133e-01 0.153 0 0
Specification of primordial germ cells R-HSA-9827857 7.024133e-01 0.153 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.024133e-01 0.153 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.026076e-01 0.153 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.030158e-01 0.153 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.042351e-01 0.152 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.042351e-01 0.152 0 0
RUNX2 regulates bone development R-HSA-8941326 7.042894e-01 0.152 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.063073e-01 0.151 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.063073e-01 0.151 0 0
phospho-PLA2 pathway R-HSA-111995 7.063073e-01 0.151 0 0
MET receptor recycling R-HSA-8875656 7.063073e-01 0.151 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.063073e-01 0.151 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.063073e-01 0.151 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.063073e-01 0.151 0 0
Adrenoceptors R-HSA-390696 7.063073e-01 0.151 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.063073e-01 0.151 0 0
Co-stimulation by ICOS R-HSA-9927354 7.063073e-01 0.151 0 0
Activation of RAS in B cells R-HSA-1169092 7.063073e-01 0.151 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.063073e-01 0.151 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.063073e-01 0.151 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.063073e-01 0.151 0 0
Interleukin-23 signaling R-HSA-9020933 7.063073e-01 0.151 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.105045e-01 0.148 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.105045e-01 0.148 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.170862e-01 0.144 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.170862e-01 0.144 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.170862e-01 0.144 0 0
Diseases of DNA repair R-HSA-9675135 7.170862e-01 0.144 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.183192e-01 0.144 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.208006e-01 0.142 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.252040e-01 0.140 0 0
GAB1 signalosome R-HSA-180292 7.252040e-01 0.140 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 7.252040e-01 0.140 0 0
Platelet sensitization by LDL R-HSA-432142 7.252040e-01 0.140 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.252040e-01 0.140 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.252040e-01 0.140 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.291015e-01 0.137 0 0
Telomere Extension By Telomerase R-HSA-171319 7.291015e-01 0.137 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.291015e-01 0.137 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.291015e-01 0.137 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.291015e-01 0.137 0 0
Inflammasomes R-HSA-622312 7.291015e-01 0.137 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.291239e-01 0.137 0 0
IRS-mediated signalling R-HSA-112399 7.291261e-01 0.137 0 0
MET promotes cell motility R-HSA-8875878 7.368461e-01 0.133 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.368461e-01 0.133 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.372748e-01 0.132 0 0
WNT mediated activation of DVL R-HSA-201688 7.372748e-01 0.132 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.372748e-01 0.132 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.372748e-01 0.132 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.372748e-01 0.132 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.372748e-01 0.132 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.372748e-01 0.132 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.372748e-01 0.132 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.372748e-01 0.132 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.372748e-01 0.132 1 1
Defects in biotin (Btn) metabolism R-HSA-3323169 7.372748e-01 0.132 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.372748e-01 0.132 0 0
HCMV Infection R-HSA-9609646 7.383947e-01 0.132 0 0
ABC transporter disorders R-HSA-5619084 7.398139e-01 0.131 0 0
Gluconeogenesis R-HSA-70263 7.456934e-01 0.127 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.464990e-01 0.127 0 0
Other interleukin signaling R-HSA-449836 7.464990e-01 0.127 0 0
DNA methylation R-HSA-5334118 7.467463e-01 0.127 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.467463e-01 0.127 0 0
Glucagon-type ligand receptors R-HSA-420092 7.467463e-01 0.127 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.510781e-01 0.124 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.520761e-01 0.124 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.532289e-01 0.123 0 0
Leishmania infection R-HSA-9658195 7.535988e-01 0.123 0 0
Parasitic Infection Pathways R-HSA-9824443 7.535988e-01 0.123 0 0
Extension of Telomeres R-HSA-180786 7.547458e-01 0.122 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.634595e-01 0.117 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.634595e-01 0.117 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.634595e-01 0.117 0 0
COPII-mediated vesicle transport R-HSA-204005 7.636573e-01 0.117 0 0
Interleukin-17 signaling R-HSA-448424 7.636573e-01 0.117 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.649786e-01 0.116 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.649786e-01 0.116 0 0
Binding and entry of HIV virion R-HSA-173107 7.649786e-01 0.116 0 0
Signal attenuation R-HSA-74749 7.649786e-01 0.116 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.649786e-01 0.116 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.649786e-01 0.116 0 0
PI3K/AKT activation R-HSA-198203 7.649786e-01 0.116 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.649786e-01 0.116 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.649786e-01 0.116 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.649786e-01 0.116 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.663603e-01 0.116 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.663603e-01 0.116 0 0
Creatine metabolism R-HSA-71288 7.663603e-01 0.116 0 0
Protein hydroxylation R-HSA-9629569 7.663603e-01 0.116 0 0
Formation of definitive endoderm R-HSA-9823730 7.663603e-01 0.116 0 0
Generation of second messenger molecules R-HSA-202433 7.666186e-01 0.115 0 0
tRNA Aminoacylation R-HSA-379724 7.668726e-01 0.115 0 0
Signaling by FGFR R-HSA-190236 7.702438e-01 0.113 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.721033e-01 0.112 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.747000e-01 0.111 0 0
Cargo concentration in the ER R-HSA-5694530 7.792650e-01 0.108 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.804854e-01 0.108 0 0
The phototransduction cascade R-HSA-2514856 7.844983e-01 0.105 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.848535e-01 0.105 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.848535e-01 0.105 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.848535e-01 0.105 0 0
Signalling to RAS R-HSA-167044 7.848535e-01 0.105 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.848535e-01 0.105 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.853575e-01 0.105 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.897626e-01 0.103 0 0
Signaling by APC mutants R-HSA-4839744 7.897626e-01 0.103 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.897626e-01 0.103 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.897626e-01 0.103 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.897626e-01 0.103 0 0
vRNP Assembly R-HSA-192905 7.897626e-01 0.103 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.897626e-01 0.103 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.897626e-01 0.103 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.897626e-01 0.103 0 0
Suppression of apoptosis R-HSA-9635465 7.897626e-01 0.103 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.897626e-01 0.103 0 0
Mitochondrial protein import R-HSA-1268020 7.897776e-01 0.102 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.897776e-01 0.102 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.922426e-01 0.101 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.941896e-01 0.100 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.941896e-01 0.100 0 0
Neddylation R-HSA-8951664 7.979978e-01 0.098 0 0
Generic Transcription Pathway R-HSA-212436 8.006533e-01 0.097 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.020461e-01 0.096 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.020461e-01 0.096 0 0
Serine metabolism R-HSA-977347 8.020461e-01 0.096 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.020461e-01 0.096 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.020461e-01 0.096 0 0
Activation of GABAB receptors R-HSA-991365 8.062483e-01 0.094 0 0
GABA B receptor activation R-HSA-977444 8.062483e-01 0.094 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.062483e-01 0.094 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.082622e-01 0.092 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.082622e-01 0.092 0 0
Insulin receptor signalling cascade R-HSA-74751 8.109214e-01 0.091 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.119343e-01 0.090 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.119343e-01 0.090 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.119343e-01 0.090 0 0
Signaling by AXIN mutants R-HSA-4839735 8.119343e-01 0.090 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.119343e-01 0.090 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.119343e-01 0.090 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.119343e-01 0.090 0 0
Sodium/Calcium exchangers R-HSA-425561 8.119343e-01 0.090 0 0
FGFR2 alternative splicing R-HSA-6803529 8.180068e-01 0.087 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 8.180068e-01 0.087 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.180068e-01 0.087 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.215136e-01 0.085 0 0
Reproduction R-HSA-1474165 8.244978e-01 0.084 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.245613e-01 0.084 0 0
Interferon gamma signaling R-HSA-877300 8.293024e-01 0.081 0 0
Amine ligand-binding receptors R-HSA-375280 8.294941e-01 0.081 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.317690e-01 0.080 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.317690e-01 0.080 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.317690e-01 0.080 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.317690e-01 0.080 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.317690e-01 0.080 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.317690e-01 0.080 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.317690e-01 0.080 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.317690e-01 0.080 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.317690e-01 0.080 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.317690e-01 0.080 0 0
Regulation of IFNG signaling R-HSA-877312 8.317690e-01 0.080 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.317690e-01 0.080 0 0
Interleukin-15 signaling R-HSA-8983432 8.317690e-01 0.080 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.328040e-01 0.079 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.328040e-01 0.079 0 0
Translation of Structural Proteins R-HSA-9694635 8.330205e-01 0.079 0 0
eNOS activation R-HSA-203615 8.339755e-01 0.079 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.339755e-01 0.079 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.339755e-01 0.079 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.339755e-01 0.079 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.387438e-01 0.076 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.394640e-01 0.076 0 0
Platelet homeostasis R-HSA-418346 8.441234e-01 0.074 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.456805e-01 0.073 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.456805e-01 0.073 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.456805e-01 0.073 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.465056e-01 0.072 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.465056e-01 0.072 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.465056e-01 0.072 0 0
Telomere Maintenance R-HSA-157579 8.475045e-01 0.072 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.481288e-01 0.072 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.481676e-01 0.072 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.495128e-01 0.071 0 0
Chylomicron remodeling R-HSA-8963901 8.495128e-01 0.071 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.495128e-01 0.071 0 0
Formation of axial mesoderm R-HSA-9796292 8.495128e-01 0.071 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.495128e-01 0.071 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.495128e-01 0.071 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.495128e-01 0.071 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.495128e-01 0.071 0 0
Maturation of nucleoprotein R-HSA-9683610 8.495128e-01 0.071 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 8.495128e-01 0.071 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.503714e-01 0.070 0 0
Regulation of insulin secretion R-HSA-422356 8.546037e-01 0.068 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.591781e-01 0.066 0 0
Laminin interactions R-HSA-3000157 8.591781e-01 0.066 0 0
Hyaluronan degradation R-HSA-2160916 8.591781e-01 0.066 0 0
Synthesis of PC R-HSA-1483191 8.599718e-01 0.066 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.653860e-01 0.063 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.653860e-01 0.063 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.653860e-01 0.063 0 0
Hydrolysis of LPC R-HSA-1483115 8.653860e-01 0.063 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.653860e-01 0.063 0 0
Physiological factors R-HSA-5578768 8.653860e-01 0.063 0 0
Malate-aspartate shuttle R-HSA-9856872 8.653860e-01 0.063 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.653860e-01 0.063 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.653860e-01 0.063 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.653860e-01 0.063 0 0
Zinc transporters R-HSA-435354 8.653860e-01 0.063 0 0
Peroxisomal protein import R-HSA-9033241 8.655416e-01 0.063 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.655416e-01 0.063 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.669529e-01 0.062 0 0
Metal ion SLC transporters R-HSA-425410 8.690410e-01 0.061 0 0
MET activates PTK2 signaling R-HSA-8874081 8.708861e-01 0.060 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.708861e-01 0.060 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.724824e-01 0.059 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.734206e-01 0.059 0 0
HCMV Late Events R-HSA-9610379 8.749659e-01 0.058 0 0
Signaling by Insulin receptor R-HSA-74752 8.791995e-01 0.056 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.795858e-01 0.056 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.795858e-01 0.056 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.795858e-01 0.056 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.795858e-01 0.056 0 0
p38MAPK events R-HSA-171007 8.795858e-01 0.056 0 0
Protein repair R-HSA-5676934 8.795858e-01 0.056 0 0
Biotin transport and metabolism R-HSA-196780 8.795858e-01 0.056 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.795858e-01 0.056 0 0
Other semaphorin interactions R-HSA-416700 8.795858e-01 0.056 0 0
Signaling by Activin R-HSA-1502540 8.795858e-01 0.056 0 0
DNA Damage Reversal R-HSA-73942 8.795858e-01 0.056 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.816919e-01 0.055 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.816919e-01 0.055 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.816919e-01 0.055 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.816919e-01 0.055 0 0
Insulin processing R-HSA-264876 8.816919e-01 0.055 0 0
Triglyceride biosynthesis R-HSA-75109 8.816919e-01 0.055 0 0
Synthesis of PE R-HSA-1483213 8.816919e-01 0.055 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.855958e-01 0.053 0 0
PI3K Cascade R-HSA-109704 8.856696e-01 0.053 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.860680e-01 0.053 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.884863e-01 0.051 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.912412e-01 0.050 0 0
Insulin receptor recycling R-HSA-77387 8.916556e-01 0.050 0 0
Pyroptosis R-HSA-5620971 8.916556e-01 0.050 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.922884e-01 0.049 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.922884e-01 0.049 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.922884e-01 0.049 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.922884e-01 0.049 0 0
Fructose catabolism R-HSA-70350 8.922884e-01 0.049 0 0
Attachment and Entry R-HSA-9678110 8.922884e-01 0.049 0 0
Meiotic recombination R-HSA-912446 8.932712e-01 0.049 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.940129e-01 0.049 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.940129e-01 0.049 0 0
Diseases of Immune System R-HSA-5260271 8.940129e-01 0.049 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.940129e-01 0.049 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.940129e-01 0.049 0 0
Interleukin-2 family signaling R-HSA-451927 8.940129e-01 0.049 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.971807e-01 0.047 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.971807e-01 0.047 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.988137e-01 0.046 0 0
Transmission across Chemical Synapses R-HSA-112315 8.990401e-01 0.046 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.004254e-01 0.046 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.004254e-01 0.046 0 0
mRNA Capping R-HSA-72086 9.008346e-01 0.045 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.008346e-01 0.045 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.008346e-01 0.045 0 0
DARPP-32 events R-HSA-180024 9.008346e-01 0.045 0 0
Signaling by Erythropoietin R-HSA-9006335 9.008346e-01 0.045 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.018693e-01 0.045 0 0
Fibronectin matrix formation R-HSA-1566977 9.036517e-01 0.044 0 0
Heme assimilation R-HSA-9927020 9.036517e-01 0.044 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.036517e-01 0.044 0 0
Synthesis of PG R-HSA-1483148 9.036517e-01 0.044 0 0
Galactose catabolism R-HSA-70370 9.036517e-01 0.044 0 0
Coenzyme A biosynthesis R-HSA-196783 9.036517e-01 0.044 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.036517e-01 0.044 0 0
Protein localization R-HSA-9609507 9.043106e-01 0.044 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.074105e-01 0.042 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.091960e-01 0.041 0 0
HIV Transcription Initiation R-HSA-167161 9.091960e-01 0.041 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.091960e-01 0.041 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.091960e-01 0.041 0 0
Intra-Golgi traffic R-HSA-6811438 9.091960e-01 0.041 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.091960e-01 0.041 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.091960e-01 0.041 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.092835e-01 0.041 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.138168e-01 0.039 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.138168e-01 0.039 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.138168e-01 0.039 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.138168e-01 0.039 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.138168e-01 0.039 0 0
Choline catabolism R-HSA-6798163 9.138168e-01 0.039 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.138168e-01 0.039 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 9.138168e-01 0.039 0 0
Integrin cell surface interactions R-HSA-216083 9.156311e-01 0.038 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.160227e-01 0.038 0 0
Depyrimidination R-HSA-73928 9.160227e-01 0.038 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.170541e-01 0.038 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.170541e-01 0.038 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.194079e-01 0.036 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.223784e-01 0.035 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.229100e-01 0.035 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.229100e-01 0.035 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.229100e-01 0.035 0 0
Mismatch Repair R-HSA-5358508 9.229100e-01 0.035 0 0
Ion channel transport R-HSA-983712 9.239444e-01 0.034 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.241955e-01 0.034 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.273657e-01 0.033 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.283136e-01 0.032 0 0
Amyloid fiber formation R-HSA-977225 9.299595e-01 0.032 0 0
Toll-like Receptor Cascades R-HSA-168898 9.300669e-01 0.031 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.310443e-01 0.031 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.310443e-01 0.031 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.310443e-01 0.031 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.310443e-01 0.031 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.310443e-01 0.031 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.310443e-01 0.031 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.310443e-01 0.031 0 0
Specification of the neural plate border R-HSA-9834899 9.310443e-01 0.031 0 0
Diseases of hemostasis R-HSA-9671793 9.310443e-01 0.031 0 0
HDL remodeling R-HSA-8964058 9.310443e-01 0.031 0 0
Maturation of nucleoprotein R-HSA-9694631 9.310443e-01 0.031 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.313690e-01 0.031 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.337867e-01 0.030 0 0
Somitogenesis R-HSA-9824272 9.337867e-01 0.030 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.338381e-01 0.030 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.341624e-01 0.030 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.350809e-01 0.029 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.350809e-01 0.029 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.355147e-01 0.029 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.367728e-01 0.028 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.367728e-01 0.028 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.367728e-01 0.028 0 0
Neuronal System R-HSA-112316 9.379597e-01 0.028 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.383206e-01 0.028 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.383206e-01 0.028 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.383206e-01 0.028 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.383206e-01 0.028 0 0
Signaling by TGFBR3 R-HSA-9839373 9.388917e-01 0.027 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.396563e-01 0.027 0 0
Hemostasis R-HSA-109582 9.401130e-01 0.027 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.422929e-01 0.026 0 0
Hyaluronan metabolism R-HSA-2142845 9.422929e-01 0.026 0 0
GABA receptor activation R-HSA-977443 9.439360e-01 0.025 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.448296e-01 0.025 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.448296e-01 0.025 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.448296e-01 0.025 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.448296e-01 0.025 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.448296e-01 0.025 0 0
Lagging Strand Synthesis R-HSA-69186 9.448296e-01 0.025 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.473526e-01 0.023 0 0
Ribavirin ADME R-HSA-9755088 9.506520e-01 0.022 0 0
Glutathione synthesis and recycling R-HSA-174403 9.506520e-01 0.022 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.506520e-01 0.022 0 0
Attachment and Entry R-HSA-9694614 9.506520e-01 0.022 0 0
GPVI-mediated activation cascade R-HSA-114604 9.519875e-01 0.021 0 0
Glycosphingolipid transport R-HSA-9845576 9.519875e-01 0.021 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.519875e-01 0.021 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.519875e-01 0.021 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.521001e-01 0.021 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.558602e-01 0.020 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.558602e-01 0.020 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.558602e-01 0.020 0 0
Cellular hexose transport R-HSA-189200 9.558602e-01 0.020 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.558602e-01 0.020 0 0
Fructose metabolism R-HSA-5652084 9.558602e-01 0.020 0 0
Ethanol oxidation R-HSA-71384 9.558602e-01 0.020 0 0
Immune System R-HSA-168256 9.580404e-01 0.019 0 0
Complex IV assembly R-HSA-9864848 9.593692e-01 0.018 0 0
Elastic fibre formation R-HSA-1566948 9.601136e-01 0.018 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.601136e-01 0.018 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.605190e-01 0.017 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.605190e-01 0.017 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.605190e-01 0.017 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.605190e-01 0.017 0 0
Formation of the ureteric bud R-HSA-9830674 9.605190e-01 0.017 0 0
Growth hormone receptor signaling R-HSA-982772 9.605190e-01 0.017 0 0
Biosynthesis of maresins R-HSA-9018682 9.605190e-01 0.017 0 0
Adaptive Immune System R-HSA-1280218 9.614941e-01 0.017 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.619812e-01 0.017 0 0
Neurotransmitter release cycle R-HSA-112310 9.634070e-01 0.016 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.642828e-01 0.016 0 0
Cardiac conduction R-HSA-5576891 9.645447e-01 0.016 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.646864e-01 0.016 0 0
Interleukin-6 family signaling R-HSA-6783589 9.646864e-01 0.016 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.646864e-01 0.016 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.648492e-01 0.016 0 0
PI Metabolism R-HSA-1483255 9.674552e-01 0.014 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.677469e-01 0.014 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.683562e-01 0.014 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.684141e-01 0.014 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.684141e-01 0.014 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.684141e-01 0.014 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.684141e-01 0.014 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.684141e-01 0.014 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.684141e-01 0.014 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.684141e-01 0.014 0 0
Infectious disease R-HSA-5663205 9.695556e-01 0.013 0 0
Maturation of spike protein R-HSA-9694548 9.698767e-01 0.013 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.717485e-01 0.012 0 0
TRP channels R-HSA-3295583 9.717485e-01 0.012 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.717485e-01 0.012 0 0
Sphingolipid catabolism R-HSA-9845614 9.717485e-01 0.012 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.717485e-01 0.012 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.717485e-01 0.012 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.730230e-01 0.012 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.730230e-01 0.012 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.730230e-01 0.012 0 0
RSV-host interactions R-HSA-9833110 9.732069e-01 0.012 0 0
Collagen formation R-HSA-1474290 9.739456e-01 0.011 0 0
Mitochondrial protein degradation R-HSA-9837999 9.739456e-01 0.011 0 0
Packaging Of Telomere Ends R-HSA-171306 9.747310e-01 0.011 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.747310e-01 0.011 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.747310e-01 0.011 0 0
Signaling by BMP R-HSA-201451 9.747310e-01 0.011 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.747310e-01 0.011 0 0
Integration of energy metabolism R-HSA-163685 9.748635e-01 0.011 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.773989e-01 0.010 0 0
Pyrimidine salvage R-HSA-73614 9.773989e-01 0.010 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.775791e-01 0.010 0 0
Post-translational protein modification R-HSA-597592 9.775989e-01 0.010 0 0
Gastrulation R-HSA-9758941 9.779607e-01 0.010 0 0
Surfactant metabolism R-HSA-5683826 9.793727e-01 0.009 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.797852e-01 0.009 0 0
Metabolism of polyamines R-HSA-351202 9.810003e-01 0.008 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.819197e-01 0.008 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.825700e-01 0.008 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.838289e-01 0.007 0 0
Metabolism of proteins R-HSA-392499 9.839937e-01 0.007 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.849413e-01 0.007 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.853231e-01 0.006 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.853451e-01 0.006 0 0
Base Excision Repair R-HSA-73884 9.853465e-01 0.006 0 0
Signaling by WNT in cancer R-HSA-4791275 9.855366e-01 0.006 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.855366e-01 0.006 0 0
Intraflagellar transport R-HSA-5620924 9.859375e-01 0.006 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.859375e-01 0.006 0 0
Interleukin-10 signaling R-HSA-6783783 9.861076e-01 0.006 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.870641e-01 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.870641e-01 0.006 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.871877e-01 0.006 0 0
Azathioprine ADME R-HSA-9748787 9.884063e-01 0.005 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.884303e-01 0.005 0 0
Heme degradation R-HSA-189483 9.884303e-01 0.005 0 0
Interferon alpha/beta signaling R-HSA-909733 9.888604e-01 0.005 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.891987e-01 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.896523e-01 0.005 0 0
Gap junction assembly R-HSA-190861 9.896523e-01 0.005 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.896523e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.905505e-01 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.907454e-01 0.004 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.913359e-01 0.004 0 0
Stimuli-sensing channels R-HSA-2672351 9.917047e-01 0.004 0 0
Voltage gated Potassium channels R-HSA-1296072 9.925973e-01 0.003 0 0
Cleavage of the damaged purine R-HSA-110331 9.925973e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.925973e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.925973e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.925973e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.925973e-01 0.003 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.926987e-01 0.003 0 0
ECM proteoglycans R-HSA-3000178 9.927621e-01 0.003 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.933794e-01 0.003 0 0
Depurination R-HSA-73927 9.933794e-01 0.003 0 0
Purine salvage R-HSA-74217 9.933794e-01 0.003 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.934946e-01 0.003 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.938439e-01 0.003 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.940789e-01 0.003 0 0
Synthesis of PA R-HSA-1483166 9.941415e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.947045e-01 0.002 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.947045e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.947045e-01 0.002 0 0
Regulation of beta-cell development R-HSA-186712 9.951882e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.951882e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.952589e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.956403e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.957645e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.960507e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.961487e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.962121e-01 0.002 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.962324e-01 0.002 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.966124e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.967608e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.969705e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.972754e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.972907e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.974025e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.975891e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.976065e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.978332e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.983157e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.983894e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.984503e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.985432e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.986142e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.986142e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.986629e-01 0.001 0 0
Purine catabolism R-HSA-74259 9.986826e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.987819e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.988461e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.988689e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.989092e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.989537e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.990264e-01 0.000 0 0
Digestion R-HSA-8935690 9.992075e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.992468e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.992508e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.994310e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.994538e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.994933e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.995469e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.995483e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.996377e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.996734e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.996760e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.996872e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997136e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997136e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.997198e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997353e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.997665e-01 0.000 0 0
Kidney development R-HSA-9830369 9.997684e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997684e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998047e-01 0.000 0 0
Disease R-HSA-1643685 9.998157e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.998499e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998519e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998519e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998519e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998519e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998572e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998816e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998823e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998942e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.998942e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.998992e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999153e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999164e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999356e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999387e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999517e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999517e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999587e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999655e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999753e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999779e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999798e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999824e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999833e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999910e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999916e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999928e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999950e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999979e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999983e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999987e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999989e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999994e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999997e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999997e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999998e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999998e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways