LOK

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O43615 T106 Sugiyama TIMM44 MIMT44 TIM44 DEARRLEEsDVLQEARRKyKtIESETVRTSEVLRKKLGELT
O43615 Y104 Sugiyama TIMM44 MIMT44 TIM44 FRDEARRLEEsDVLQEARRKyKtIESETVRTSEVLRKKLGE
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75821 T240 Sugiyama EIF3G EIF3S4 DGAsRRGESMQPNRRADDNAtIRVtNLSEDTRETDLQELFR
O94804 S438 Sugiyama STK10 LOK MDARIQVAQEKQVAEQGGDLsPAANRsQKAsQsRPNssALE
O94804 S444 Sugiyama STK10 LOK VAQEKQVAEQGGDLsPAANRsQKAsQsRPNssALEtLGGEK
O94804 S448 Sugiyama STK10 LOK KQVAEQGGDLsPAANRsQKAsQsRPNssALEtLGGEKLANG
O94804 S450 Sugiyama STK10 LOK VAEQGGDLsPAANRsQKAsQsRPNssALEtLGGEKLANGsL
O94804 S454 Sugiyama STK10 LOK GGDLsPAANRsQKAsQsRPNssALEtLGGEKLANGsLEPPA
O94804 S455 iPTMNet|EPSD|Sugiyama STK10 LOK GDLsPAANRsQKAsQsRPNssALEtLGGEKLANGsLEPPAQ
O94804 S469 Sugiyama STK10 LOK QsRPNssALEtLGGEKLANGsLEPPAQAAPGPSKRDsDCss
O94804 S541 Sugiyama STK10 LOK KLYKKTLKRTRKFVVDGVEVsITtsKIISEDEKKDEEMRFL
O94804 S545 Sugiyama STK10 LOK KTLKRTRKFVVDGVEVsITtsKIISEDEKKDEEMRFLRRQE
O94804 S824 Sugiyama STK10 LOK ARLPKIQRSEGKTRMAMYKKsLHINGGGSAAEQREKIKQFS
O94804 S954 Sugiyama STK10 LOK EQEMFFKLSEEAECPNPstPsKAAKFFPySSADAs______
O94804 S968 Sugiyama STK10 LOK PNPstPsKAAKFFPySSADAs____________________
O94804 T459 Sugiyama STK10 LOK PAANRsQKAsQsRPNssALEtLGGEKLANGsLEPPAQAAPG
O94804 T544 Sugiyama STK10 LOK KKTLKRTRKFVVDGVEVsITtsKIISEDEKKDEEMRFLRRQ
O94804 T611 Sugiyama STK10 LOK LEQMHKRFEQEINAKKKFFDtELENLERQQKQQVEKMEQDH
O94804 T952 Sugiyama STK10 LOK KREQEMFFKLSEEAECPNPstPsKAAKFFPySSADAs____
O94804 Y766 Sugiyama STK10 LOK MEEHQLQERHQLVKQQLKDQyFLQRHELLRKHEKEREQMQR
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07814 T1506 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 LCELQPGAKCVCGKNPAKyytLFGRsy______________
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T637 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MGyMMAKKHLEINPDHPIVEtLRQKAEADKNDKAVKDLVVL
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P0DPH7 T334 Sugiyama TUBA3C TUBA2 ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P15311 T567 EPSD|PSP EZR VIL2 RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P26038 T558 GPS6|SIGNOR|ELM|EPSD|PSP MSN KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P31948 T243 Sugiyama STIP1 KQALKEKELGNDAYKKKDFDtALKHYDKAKELDPtNMtyIT
P35241 T564 EPSD|PSP RDX KTQNDVLHAENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM_
P35269 T41 Sugiyama GTF2F1 RAP74 NTTKKyNIMAFNAADKVNFAtWNQARLERDLSNKKIyQEEE
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P47756 T202 Sugiyama CAPZB SGsGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMEN
P53350 T210 GPS6|ELM|EPSD|PSP PLK1 PLK VKIGDFGLATKVEYDGERKKtLCGtPNyIAPEVLSKKGHSF
P55209 T269 Sugiyama NAP1L1 NRP GPEIMGCTGCQIDWKKGKNVtLKtIKKKQKHKGRGTVRTVT
P55209 T272 Sugiyama NAP1L1 NRP IMGCTGCQIDWKKGKNVtLKtIKKKQKHKGRGTVRTVTKTV
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363 T334 Sugiyama TUBA1B ACCLLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVG
Q14697 T40 Sugiyama GANAB G2AN KIAA0088 LAFLGVCLGITLAVDRSNFKtCEEssFCKRQRsIRPGLsPy
Q6PEY2 T334 Sugiyama TUBA3E ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q71U36 T334 Sugiyama TUBA1A TUBA3 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q99426 T120 Sugiyama TBCB CG22 CKAP1 DVSRVEKytIsQEAyDQRQDtVRSFLKRsKLGRyNEEERAQ
Q9BQE3 T334 Sugiyama TUBA1C TUBA6 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q9H173 T125 Sugiyama SIL1 UNQ545/PRO836 QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9ULW6 T342 Sugiyama NAP1L2 BPX GTAIEYSTGCEIDWNEGKNVtLKtIKKKQKHRIWGTIRTVT
Q9ULW6 T345 Sugiyama NAP1L2 BPX IEYSTGCEIDWNEGKNVtLKtIKKKQKHRIWGTIRTVTEDF
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9Y597 T673 Sugiyama KCTD3 sPLLARARRtEsFHSYRDFQtINLNRNVERAVPENGNLGPI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 1.357407e-09 8.867 1 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.762512e-08 7.322 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.056912e-08 7.094 0 0
Cell Cycle R-HSA-1640170 3.601149e-06 5.444 0 0
Cell Cycle, Mitotic R-HSA-69278 3.664638e-06 5.436 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.038809e-06 5.219 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.000085e-06 5.046 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.076277e-05 4.968 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.429967e-05 4.845 0 0
Cell Cycle Checkpoints R-HSA-69620 2.217515e-05 4.654 0 0
MAPK family signaling cascades R-HSA-5683057 2.584397e-05 4.588 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.908848e-05 4.408 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.310567e-05 4.365 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.310567e-05 4.365 0 0
Interleukin-12 signaling R-HSA-9020591 4.867217e-05 4.313 0 0
Apoptotic execution phase R-HSA-75153 5.456140e-05 4.263 0 0
Cellular Senescence R-HSA-2559583 7.268009e-05 4.139 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.093540e-05 4.092 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.093540e-05 4.092 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.401692e-05 4.076 0 0
Signaling by Interleukins R-HSA-449147 8.915072e-05 4.050 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.147039e-04 3.940 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.147039e-04 3.940 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.147039e-04 3.940 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.147039e-04 3.940 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.147039e-04 3.940 0 0
Integrin signaling R-HSA-354192 1.019664e-04 3.992 0 0
Signaling by ERBB2 R-HSA-1227986 9.779264e-05 4.010 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.779024e-04 3.750 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.779024e-04 3.750 0 0
Oncogene Induced Senescence R-HSA-2559585 1.761382e-04 3.754 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.763335e-04 3.754 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.957176e-04 3.708 0 0
Interleukin-12 family signaling R-HSA-447115 1.921826e-04 3.716 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.099933e-04 3.678 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.577765e-04 3.589 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.865961e-04 3.543 0 0
Interleukin-37 signaling R-HSA-9008059 3.140503e-04 3.503 0 0
Signaling by ALK R-HSA-201556 3.403008e-04 3.468 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.413300e-04 3.467 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.538431e-04 3.451 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.138719e-04 3.383 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.165388e-04 3.380 0 0
G0 and Early G1 R-HSA-1538133 4.471672e-04 3.350 0 0
Signaling by WNT in cancer R-HSA-4791275 4.471672e-04 3.350 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.472683e-04 3.349 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.546831e-04 3.342 0 0
Signaling by APC mutants R-HSA-4839744 5.309352e-04 3.275 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.309352e-04 3.275 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.309352e-04 3.275 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.309352e-04 3.275 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.689355e-04 3.329 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.291084e-04 3.276 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.941747e-04 3.306 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.546616e-04 3.256 0 0
Signaling by PTK6 R-HSA-8848021 5.546616e-04 3.256 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.279498e-04 3.277 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.259103e-04 3.279 0 0
Signaling by ALK in cancer R-HSA-9700206 5.259103e-04 3.279 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.217397e-04 3.206 0 0
Axon guidance R-HSA-422475 6.217997e-04 3.206 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.679828e-04 3.175 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.707779e-04 3.173 0 0
Long-term potentiation R-HSA-9620244 6.707779e-04 3.173 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.735656e-04 3.172 0 0
Signaling by AXIN mutants R-HSA-4839735 7.221432e-04 3.141 0 0
Polo-like kinase mediated events R-HSA-156711 7.735932e-04 3.111 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 9.207137e-04 3.036 0 0
Signaling by VEGF R-HSA-194138 9.718098e-04 3.012 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.867070e-04 3.006 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.150635e-03 2.939 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.181888e-03 2.927 0 0
Muscle contraction R-HSA-397014 1.397457e-03 2.855 0 0
RAB geranylgeranylation R-HSA-8873719 1.428033e-03 2.845 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.503753e-03 2.823 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.572887e-03 2.803 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.606729e-03 2.794 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.797971e-03 2.745 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.913647e-03 2.718 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.028577e-03 2.693 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.071419e-03 2.684 0 0
Nervous system development R-HSA-9675108 2.085536e-03 2.681 0 0
FOXO-mediated transcription R-HSA-9614085 2.103497e-03 2.677 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.125053e-03 2.673 0 0
Mitotic Prometaphase R-HSA-68877 2.385077e-03 2.622 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.462459e-03 2.609 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.526021e-03 2.598 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.526021e-03 2.598 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.825109e-03 2.549 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.825109e-03 2.549 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.825109e-03 2.549 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.916868e-03 2.535 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.958840e-03 2.529 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.106468e-03 2.508 0 0
RAF activation R-HSA-5673000 3.220540e-03 2.492 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.106468e-03 2.508 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.152468e-03 2.501 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.493531e-03 2.457 0 0
G2/M Transition R-HSA-69275 3.643430e-03 2.438 0 0
Signaling by Hippo R-HSA-2028269 3.777353e-03 2.423 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.032569e-03 2.394 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.488039e-03 2.348 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.611258e-03 2.336 0 0
Co-stimulation by CD28 R-HSA-389356 4.900754e-03 2.310 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.400488e-03 2.268 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.736352e-03 2.241 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.977849e-03 2.223 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.084967e-03 2.216 0 0
G1/S Transition R-HSA-69206 6.219641e-03 2.206 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.746445e-03 2.171 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.926562e-03 2.159 0 0
Formation of definitive endoderm R-HSA-9823730 6.406308e-03 2.193 0 0
Signaling by LTK R-HSA-9842663 6.746445e-03 2.171 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.938209e-03 2.159 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.411616e-03 2.130 0 0
Sensory processing of sound R-HSA-9659379 7.858207e-03 2.105 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.078886e-03 2.093 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.297444e-03 2.081 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 8.618244e-03 2.065 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 8.641166e-03 2.063 0 0
Regulation of TP53 Activity R-HSA-5633007 9.479637e-03 2.023 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.001545e-02 1.999 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.108671e-02 1.955 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.108671e-02 1.955 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.044168e-02 1.981 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.110888e-02 1.954 0 0
Netrin-1 signaling R-HSA-373752 1.113218e-02 1.953 0 0
Striated Muscle Contraction R-HSA-390522 1.122779e-02 1.950 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.122779e-02 1.950 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.137012e-02 1.944 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.143226e-02 1.942 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.143226e-02 1.942 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.143226e-02 1.942 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.186379e-02 1.926 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.342975e-02 1.872 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.342975e-02 1.872 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.342975e-02 1.872 0 0
Signaling by RAS mutants R-HSA-6802949 1.342975e-02 1.872 0 0
Mitophagy R-HSA-5205647 1.254026e-02 1.902 0 0
Neurodegenerative Diseases R-HSA-8863678 1.326343e-02 1.877 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.326343e-02 1.877 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.395680e-02 1.855 0 0
Mitotic Anaphase R-HSA-68882 1.467893e-02 1.833 0 0
Post NMDA receptor activation events R-HSA-438064 1.472062e-02 1.832 0 0
Diseases of cellular response to stress R-HSA-9675132 1.490649e-02 1.827 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.490649e-02 1.827 0 0
HDMs demethylate histones R-HSA-3214842 1.506436e-02 1.822 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.676911e-02 1.775 0 0
RET signaling R-HSA-8853659 1.548124e-02 1.810 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.702323e-02 1.769 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.694625e-02 1.771 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.526484e-02 1.816 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.676911e-02 1.775 0 0
TRP channels R-HSA-3295583 1.702184e-02 1.769 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.711724e-02 1.767 0 0
ESR-mediated signaling R-HSA-8939211 1.733709e-02 1.761 0 0
mRNA Splicing R-HSA-72172 1.749571e-02 1.757 0 0
Programmed Cell Death R-HSA-5357801 1.819409e-02 1.740 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.826256e-02 1.738 0 0
Semaphorin interactions R-HSA-373755 1.826256e-02 1.738 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.847847e-02 1.733 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.871164e-02 1.728 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.886834e-02 1.724 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.906868e-02 1.720 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.949903e-02 1.710 0 0
Specification of primordial germ cells R-HSA-9827857 1.949903e-02 1.710 0 0
IGF1R signaling cascade R-HSA-2428924 1.965050e-02 1.707 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.073790e-02 1.683 0 0
mRNA 3'-end processing R-HSA-72187 2.233570e-02 1.651 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.111197e-02 1.675 0 0
Adipogenesis R-HSA-9843745 2.037540e-02 1.691 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.111197e-02 1.675 0 0
Cardiac conduction R-HSA-5576891 2.037540e-02 1.691 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.073790e-02 1.683 0 0
Apoptosis R-HSA-109581 2.146063e-02 1.668 0 0
Platelet sensitization by LDL R-HSA-432142 2.248800e-02 1.648 0 0
Signal attenuation R-HSA-74749 2.272490e-02 1.643 0 0
Regulation of CDH11 function R-HSA-9762292 2.272490e-02 1.643 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.272490e-02 1.643 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.272490e-02 1.643 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.272911e-02 1.643 0 0
Separation of Sister Chromatids R-HSA-2467813 2.335679e-02 1.632 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.388212e-02 1.622 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.484500e-02 1.605 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.484500e-02 1.605 0 0
FLT3 Signaling R-HSA-9607240 2.484500e-02 1.605 0 0
Immune System R-HSA-168256 2.581412e-02 1.588 1 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.651238e-02 1.577 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.694488e-02 1.570 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.159095e-02 1.500 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.159095e-02 1.500 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.159095e-02 1.500 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.159095e-02 1.500 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.926297e-02 1.534 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.926297e-02 1.534 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.932047e-02 1.533 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.932047e-02 1.533 0 0
Signaling by EGFR R-HSA-177929 3.014853e-02 1.521 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.004304e-02 1.522 0 0
MAP2K and MAPK activation R-HSA-5674135 2.708837e-02 1.567 0 0
Interleukin-2 signaling R-HSA-9020558 2.745633e-02 1.561 0 0
Developmental Biology R-HSA-1266738 2.905190e-02 1.537 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.708837e-02 1.567 0 0
NRAGE signals death through JNK R-HSA-193648 3.014853e-02 1.521 0 0
TBC/RABGAPs R-HSA-8854214 3.196787e-02 1.495 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.305626e-02 1.481 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.368682e-02 1.473 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.836212e-02 1.416 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.836212e-02 1.416 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.712326e-02 1.430 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.548186e-02 1.450 0 0
snRNP Assembly R-HSA-191859 3.708930e-02 1.431 0 0
Metabolism of non-coding RNA R-HSA-194441 3.708930e-02 1.431 0 0
Signaling by ERBB4 R-HSA-1236394 3.785881e-02 1.422 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.836212e-02 1.416 0 0
G1 Phase R-HSA-69236 3.460864e-02 1.461 0 0
Cyclin D associated events in G1 R-HSA-69231 3.460864e-02 1.461 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 3.836212e-02 1.416 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.610079e-02 1.442 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.664730e-02 1.436 0 0
M Phase R-HSA-68886 3.535944e-02 1.451 0 0
Signaling by WNT R-HSA-195721 4.033769e-02 1.394 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.548186e-02 1.450 0 0
Signaling by TGFBR3 R-HSA-9839373 4.030217e-02 1.395 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.883993e-02 1.411 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.712326e-02 1.430 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.883993e-02 1.411 0 0
Diseases of programmed cell death R-HSA-9645723 3.757676e-02 1.425 0 0
Cell junction organization R-HSA-446728 3.781780e-02 1.422 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.851718e-02 1.414 0 0
Cell-Cell communication R-HSA-1500931 4.046742e-02 1.393 0 0
Cellular responses to stimuli R-HSA-8953897 3.587668e-02 1.445 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.712326e-02 1.430 0 0
L1CAM interactions R-HSA-373760 4.057286e-02 1.392 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.565979e-02 1.448 0 0
PI Metabolism R-HSA-1483255 3.851718e-02 1.414 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.756845e-02 1.425 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.146510e-02 1.382 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.173844e-02 1.379 0 0
IRS activation R-HSA-74713 4.173844e-02 1.379 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.173844e-02 1.379 0 0
NrCAM interactions R-HSA-447038 4.173844e-02 1.379 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.225684e-02 1.374 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.238541e-02 1.373 0 0
Nuclear import of Rev protein R-HSA-180746 4.238541e-02 1.373 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.421058e-02 1.354 0 0
Formation of axial mesoderm R-HSA-9796292 4.452335e-02 1.351 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.452335e-02 1.351 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.452335e-02 1.351 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 4.485632e-02 1.348 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 4.485632e-02 1.348 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 4.485632e-02 1.348 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 4.485632e-02 1.348 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.608199e-02 1.336 0 0
GPER1 signaling R-HSA-9634597 4.655579e-02 1.332 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.655579e-02 1.332 0 0
G alpha (12/13) signalling events R-HSA-416482 4.755745e-02 1.323 0 0
Cell-cell junction organization R-HSA-421270 4.836058e-02 1.316 0 0
Mitotic Prophase R-HSA-68875 4.837836e-02 1.315 0 0
EPH-Ephrin signaling R-HSA-2682334 4.868353e-02 1.313 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.989582e-02 1.302 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.989582e-02 1.302 0 0
G1/S-Specific Transcription R-HSA-69205 5.004345e-02 1.301 0 0
Regulation of KIT signaling R-HSA-1433559 5.114400e-02 1.291 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.292393e-02 1.276 0 0
Phosphorylation of Emi1 R-HSA-176417 5.292393e-02 1.276 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.292393e-02 1.276 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.292393e-02 1.276 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.292393e-02 1.276 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.367532e-02 1.270 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.503416e-02 1.187 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.503416e-02 1.187 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.571342e-02 1.182 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.727360e-02 1.172 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.874663e-02 1.231 0 0
Abacavir transmembrane transport R-HSA-2161517 6.503416e-02 1.187 0 0
Tight junction interactions R-HSA-420029 5.613728e-02 1.251 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.727360e-02 1.172 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.176889e-02 1.209 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.574496e-02 1.182 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.503416e-02 1.187 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.613728e-02 1.251 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.415743e-02 1.266 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.415743e-02 1.266 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.503416e-02 1.187 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.821196e-02 1.235 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.846164e-02 1.233 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.745009e-02 1.171 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.763915e-02 1.170 0 0
Interleukin-2 family signaling R-HSA-451927 6.763915e-02 1.170 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.763915e-02 1.170 0 0
Diseases of Immune System R-HSA-5260271 6.763915e-02 1.170 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.763915e-02 1.170 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.763915e-02 1.170 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.787703e-02 1.168 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.814359e-02 1.167 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.111932e-02 1.148 0 0
Signaling by TGFB family members R-HSA-9006936 7.115461e-02 1.148 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.251069e-02 1.140 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.363311e-02 1.133 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.363311e-02 1.133 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.363311e-02 1.133 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.363311e-02 1.133 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.490499e-02 1.125 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.533777e-02 1.123 0 0
Signaling by FGFR1 R-HSA-5654736 7.731230e-02 1.112 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.731230e-02 1.112 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.756896e-02 1.110 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.796389e-02 1.108 0 0
Netrin mediated repulsion signals R-HSA-418886 7.796389e-02 1.108 0 0
MECP2 regulates transcription factors R-HSA-9022707 7.796389e-02 1.108 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.946320e-02 1.100 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 8.770314e-02 1.057 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 8.770314e-02 1.057 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 8.770314e-02 1.057 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 9.161547e-02 1.038 0 0
FGFR1b ligand binding and activation R-HSA-190370 9.161547e-02 1.038 0 0
Activation of RAS in B cells R-HSA-1169092 9.161547e-02 1.038 0 0
WNT mediated activation of DVL R-HSA-201688 1.058983e-01 0.975 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.195462e-02 1.086 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.066051e-02 1.043 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.066051e-02 1.043 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 1.091520e-01 0.962 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.644109e-02 1.063 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.282509e-02 1.082 0 0
Centrosome maturation R-HSA-380287 9.120783e-02 1.040 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.046386e-01 0.980 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.973257e-02 1.001 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.058983e-01 0.975 0 0
Signaling by FGFR4 R-HSA-5654743 8.823827e-02 1.054 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.058983e-01 0.975 0 0
Signaling by FGFR3 R-HSA-5654741 9.962886e-02 1.002 0 0
Calcineurin activates NFAT R-HSA-2025928 1.058983e-01 0.975 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.714132e-02 1.013 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.695887e-02 1.061 0 0
Signaling by SCF-KIT R-HSA-1433557 8.823827e-02 1.054 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.068393e-01 0.971 0 0
G-protein beta:gamma signalling R-HSA-397795 1.068393e-01 0.971 0 0
Inhibition of PKR R-HSA-169131 8.770314e-02 1.057 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.058983e-01 0.975 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.962886e-02 1.002 0 0
Ca2+ pathway R-HSA-4086398 8.282509e-02 1.082 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.928932e-02 1.049 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.973257e-02 1.001 0 0
Signaling by NOTCH1 R-HSA-1980143 9.557131e-02 1.020 0 0
Gene expression (Transcription) R-HSA-74160 1.071241e-01 0.970 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.281220e-02 1.082 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.266765e-02 1.033 0 0
Cellular responses to stress R-HSA-2262752 9.574040e-02 1.019 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.120783e-02 1.040 0 0
Death Receptor Signaling R-HSA-73887 1.032288e-01 0.986 0 0
Rap1 signalling R-HSA-392517 9.973257e-02 1.001 0 0
tRNA processing in the nucleus R-HSA-6784531 1.063842e-01 0.973 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.058983e-01 0.975 0 0
Apoptotic factor-mediated response R-HSA-111471 9.066051e-02 1.043 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.066051e-02 1.043 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.494072e-02 1.023 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.055876e-01 0.976 0 0
Interleukin-1 family signaling R-HSA-446652 9.700636e-02 1.013 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.101687e-02 1.041 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.096246e-01 0.960 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.096246e-01 0.960 0 0
Recycling pathway of L1 R-HSA-437239 1.117176e-01 0.952 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.142709e-01 0.942 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.142709e-01 0.942 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.162208e-01 0.935 0 0
Insulin receptor signalling cascade R-HSA-74751 1.171739e-01 0.931 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 1.188994e-01 0.925 0 0
Signalling to RAS R-HSA-167044 1.188994e-01 0.925 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.207285e-01 0.918 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.207285e-01 0.918 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.207285e-01 0.918 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.207285e-01 0.918 0 0
RNA Polymerase II Transcription R-HSA-73857 1.224034e-01 0.912 0 0
Generic Transcription Pathway R-HSA-212436 1.252740e-01 0.902 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.281455e-01 0.892 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.286304e-01 0.891 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.286304e-01 0.891 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.286304e-01 0.891 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.286304e-01 0.891 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.286304e-01 0.891 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.286304e-01 0.891 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.286304e-01 0.891 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.286304e-01 0.891 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.289554e-01 0.890 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.289554e-01 0.890 0 0
Signalling to ERKs R-HSA-187687 1.297877e-01 0.887 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.360284e-01 0.866 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.360284e-01 0.866 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.360284e-01 0.866 0 0
Formation of the posterior neural plate R-HSA-9832991 1.360284e-01 0.866 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.360284e-01 0.866 0 0
PECAM1 interactions R-HSA-210990 1.360284e-01 0.866 0 0
Deubiquitination R-HSA-5688426 1.365263e-01 0.865 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.677239e-01 0.775 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.677239e-01 0.775 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.677239e-01 0.775 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 1.677239e-01 0.775 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.677239e-01 0.775 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.677239e-01 0.775 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.677239e-01 0.775 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.677239e-01 0.775 0 0
Potassium transport channels R-HSA-1296067 1.677239e-01 0.775 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.677239e-01 0.775 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.677239e-01 0.775 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.677239e-01 0.775 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.677239e-01 0.775 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.677239e-01 0.775 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.677239e-01 0.775 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.050658e-01 0.688 0 0
Invadopodia formation R-HSA-8941237 2.050658e-01 0.688 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.050658e-01 0.688 0 0
Classical Kir channels R-HSA-1296053 2.050658e-01 0.688 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.517261e-01 0.819 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.517261e-01 0.819 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.517261e-01 0.819 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.840548e-01 0.735 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.005682e-01 0.698 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.607757e-01 0.794 0 0
Voltage gated Potassium channels R-HSA-1296072 1.461222e-01 0.835 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.946603e-01 0.711 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 1.946603e-01 0.711 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.736138e-01 0.760 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.840548e-01 0.735 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.739539e-01 0.760 0 0
Myogenesis R-HSA-525793 1.831686e-01 0.737 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.461222e-01 0.835 0 0
TGFBR3 expression R-HSA-9839394 1.718673e-01 0.765 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.719191e-01 0.765 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.677553e-01 0.775 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.840548e-01 0.735 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.840548e-01 0.735 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.403070e-01 0.853 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.899468e-01 0.721 0 0
Parasite infection R-HSA-9664407 1.899468e-01 0.721 0 0
Leishmania phagocytosis R-HSA-9664417 1.899468e-01 0.721 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.840548e-01 0.735 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.725843e-01 0.763 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.831686e-01 0.737 0 0
GPVI-mediated activation cascade R-HSA-114604 1.378570e-01 0.861 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.707238e-01 0.768 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.517261e-01 0.819 0 0
Repression of WNT target genes R-HSA-4641265 1.677553e-01 0.775 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.050777e-01 0.688 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.050777e-01 0.688 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.050777e-01 0.688 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.050777e-01 0.688 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.907588e-01 0.720 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.694245e-01 0.771 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.677239e-01 0.775 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.517261e-01 0.819 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.840548e-01 0.735 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.607757e-01 0.794 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.628061e-01 0.788 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.778233e-01 0.750 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.628061e-01 0.788 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.778233e-01 0.750 0 0
S Phase R-HSA-69242 1.469925e-01 0.833 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.499133e-01 0.824 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.653728e-01 0.782 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.856395e-01 0.731 0 0
Adherens junctions interactions R-HSA-418990 1.387296e-01 0.858 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.050777e-01 0.688 0 0
Acyl chain remodelling of PS R-HSA-1482801 1.718673e-01 0.765 0 0
Neuronal System R-HSA-112316 1.896598e-01 0.722 0 0
Cellular response to chemical stress R-HSA-9711123 1.785848e-01 0.748 0 0
Interleukin-15 signaling R-HSA-8983432 1.677553e-01 0.775 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.050658e-01 0.688 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.005682e-01 0.698 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.831686e-01 0.737 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.452729e-01 0.838 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.831686e-01 0.737 0 0
Histamine receptors R-HSA-390650 2.050658e-01 0.688 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.607757e-01 0.794 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.393000e-01 0.856 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.677239e-01 0.775 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.050658e-01 0.688 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.831686e-01 0.737 0 0
Platelet homeostasis R-HSA-418346 1.794730e-01 0.746 0 0
HDL assembly R-HSA-8963896 2.005682e-01 0.698 0 0
Glycolysis R-HSA-70171 1.426593e-01 0.846 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.049678e-01 0.688 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.734705e-01 0.761 0 0
Signal regulatory protein family interactions R-HSA-391160 2.005682e-01 0.698 0 0
Signaling by NOTCH3 R-HSA-9012852 1.664467e-01 0.779 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.628061e-01 0.788 0 0
Growth hormone receptor signaling R-HSA-982772 1.499133e-01 0.824 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.946603e-01 0.711 0 0
Gene Silencing by RNA R-HSA-211000 1.850465e-01 0.733 0 0
Stimuli-sensing channels R-HSA-2672351 1.906934e-01 0.720 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.677553e-01 0.775 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.377334e-01 0.861 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.063236e-01 0.685 0 0
Pyroptosis R-HSA-5620971 2.063236e-01 0.685 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.063236e-01 0.685 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.063236e-01 0.685 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 2.407345e-01 0.618 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.407345e-01 0.618 0 0
Nucleotide catabolism defects R-HSA-9735786 2.407345e-01 0.618 0 0
Signaling by LRP5 mutants R-HSA-5339717 2.407345e-01 0.618 0 0
Activation of AMPA receptors R-HSA-399710 2.748047e-01 0.561 0 0
G2 Phase R-HSA-68911 2.748047e-01 0.561 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.748047e-01 0.561 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.748047e-01 0.561 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.073481e-01 0.512 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.073481e-01 0.512 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.073481e-01 0.512 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.073481e-01 0.512 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 3.073481e-01 0.512 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.073481e-01 0.512 0 0
STAT5 Activation R-HSA-9645135 3.384331e-01 0.471 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.384331e-01 0.471 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.172436e-01 0.663 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.172436e-01 0.663 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.172436e-01 0.663 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.340333e-01 0.631 0 0
Phosphorylation of the APC/C R-HSA-176412 2.340333e-01 0.631 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.681247e-01 0.434 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.681247e-01 0.434 0 0
SOS-mediated signalling R-HSA-112412 3.681247e-01 0.434 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.681247e-01 0.434 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.964855e-01 0.402 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.964855e-01 0.402 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.964855e-01 0.402 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.964855e-01 0.402 0 0
PKA activation in glucagon signalling R-HSA-164378 2.846692e-01 0.546 0 0
Trafficking of AMPA receptors R-HSA-399719 2.421588e-01 0.616 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.182297e-01 0.661 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.665783e-01 0.574 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.788968e-01 0.555 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.515233e-01 0.454 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.679337e-01 0.434 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.295541e-01 0.639 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.295541e-01 0.639 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.161033e-01 0.500 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.548188e-01 0.594 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.002405e-01 0.398 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.781232e-01 0.422 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.885303e-01 0.540 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 2.583198e-01 0.588 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.159252e-01 0.500 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.159252e-01 0.500 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.439467e-01 0.464 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.439467e-01 0.464 0 0
PKR-mediated signaling R-HSA-9833482 3.787048e-01 0.422 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.036740e-01 0.518 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.181397e-01 0.661 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 2.300907e-01 0.638 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.349678e-01 0.475 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.349678e-01 0.475 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.036740e-01 0.518 0 0
Co-inhibition by PD-1 R-HSA-389948 2.119583e-01 0.674 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.677845e-01 0.572 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.677845e-01 0.572 0 0
DAP12 signaling R-HSA-2424491 2.300907e-01 0.638 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.533902e-01 0.452 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.159252e-01 0.500 0 0
Ephrin signaling R-HSA-3928664 2.846692e-01 0.546 0 0
EGFR downregulation R-HSA-182971 2.421588e-01 0.616 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.681247e-01 0.434 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.573145e-01 0.590 0 0
Signaling by FGFR R-HSA-190236 2.376464e-01 0.624 0 0
GAB1 signalosome R-HSA-180292 2.846692e-01 0.546 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.912671e-01 0.536 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.182899e-01 0.497 0 0
Signaling by Insulin receptor R-HSA-74752 3.280824e-01 0.484 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.665783e-01 0.574 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.340333e-01 0.631 0 0
Killing mechanisms R-HSA-9664420 2.340333e-01 0.631 0 0
Signaling by FGFR2 R-HSA-5654738 2.204992e-01 0.657 0 0
Regulation of gap junction activity R-HSA-191650 2.407345e-01 0.618 0 0
PKA activation R-HSA-163615 2.846692e-01 0.546 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.841788e-01 0.415 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.501026e-01 0.602 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.243207e-01 0.649 0 0
Developmental Cell Lineages R-HSA-9734767 2.337010e-01 0.631 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.349678e-01 0.475 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.748047e-01 0.561 0 0
Activation of AKT2 R-HSA-165158 2.748047e-01 0.561 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.748047e-01 0.561 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.681247e-01 0.434 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.300907e-01 0.638 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.912671e-01 0.536 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.131395e-01 0.671 0 0
IRS-mediated signalling R-HSA-112399 3.489480e-01 0.457 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.904179e-01 0.408 0 0
Defective pyroptosis R-HSA-9710421 4.148129e-01 0.382 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.790295e-01 0.554 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.924999e-01 0.406 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.673016e-01 0.573 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.748047e-01 0.561 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.073481e-01 0.512 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 2.172436e-01 0.663 0 0
p38MAPK events R-HSA-171007 2.172436e-01 0.663 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.677845e-01 0.572 0 0
Attenuation phase R-HSA-3371568 3.657770e-01 0.437 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.781232e-01 0.422 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 3.360850e-01 0.474 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.846692e-01 0.546 0 0
Chromatin modifying enzymes R-HSA-3247509 2.816917e-01 0.550 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.657770e-01 0.437 0 0
TNF signaling R-HSA-75893 3.386489e-01 0.470 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.846692e-01 0.546 0 0
G2/M Checkpoints R-HSA-69481 2.096261e-01 0.679 0 0
Specification of the neural plate border R-HSA-9834899 3.015145e-01 0.521 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.181397e-01 0.661 0 0
Dopamine receptors R-HSA-390651 2.407345e-01 0.618 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.748047e-01 0.561 0 0
Suppression of autophagy R-HSA-9636569 2.748047e-01 0.561 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.073481e-01 0.512 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.384331e-01 0.471 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 3.384331e-01 0.471 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.340333e-01 0.631 0 0
Adrenoceptors R-HSA-390696 3.964855e-01 0.402 0 0
Co-stimulation by ICOS R-HSA-9927354 3.964855e-01 0.402 0 0
Platelet calcium homeostasis R-HSA-418360 2.181397e-01 0.661 0 0
PI3K Cascade R-HSA-109704 2.773572e-01 0.557 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.841788e-01 0.415 0 0
Regulation of CDH1 Function R-HSA-9764561 3.489480e-01 0.457 0 0
Kinesins R-HSA-983189 3.798365e-01 0.420 0 0
Chromatin organization R-HSA-4839726 2.587084e-01 0.587 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.982622e-01 0.525 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.982622e-01 0.525 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.876913e-01 0.412 0 0
Gastrulation R-HSA-9758941 2.418305e-01 0.616 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.576747e-01 0.589 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.508936e-01 0.601 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.964855e-01 0.402 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.181397e-01 0.661 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.665783e-01 0.574 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.912671e-01 0.536 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.657770e-01 0.437 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.657770e-01 0.437 0 0
Adaptive Immune System R-HSA-1280218 2.952909e-01 0.530 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.073481e-01 0.512 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.172436e-01 0.663 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.543269e-01 0.595 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.665783e-01 0.574 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.894662e-01 0.538 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.003523e-01 0.398 0 0
Parasitic Infection Pathways R-HSA-9824443 3.112235e-01 0.507 0 0
Leishmania infection R-HSA-9658195 3.112235e-01 0.507 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.182297e-01 0.661 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.515233e-01 0.454 0 0
Transmission across Chemical Synapses R-HSA-112315 3.154288e-01 0.501 0 0
Regulation of BACH1 activity R-HSA-9708530 2.340333e-01 0.631 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 3.841788e-01 0.415 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.341170e-01 0.631 0 0
Rab regulation of trafficking R-HSA-9007101 2.570962e-01 0.590 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.665783e-01 0.574 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.364207e-01 0.626 0 0
Ion homeostasis R-HSA-5578775 3.386489e-01 0.470 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.045019e-01 0.393 0 0
NADE modulates death signalling R-HSA-205025 2.407345e-01 0.618 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.748047e-01 0.561 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.073481e-01 0.512 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.073481e-01 0.512 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.340333e-01 0.631 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.681247e-01 0.434 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.681247e-01 0.434 0 0
Phase 2 - plateau phase R-HSA-5576893 2.508936e-01 0.601 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.964855e-01 0.402 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.964855e-01 0.402 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.964855e-01 0.402 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.912671e-01 0.536 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.131395e-01 0.671 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.002405e-01 0.398 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.180910e-01 0.497 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.787048e-01 0.422 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.959796e-01 0.529 0 0
Regulated Necrosis R-HSA-5218859 2.720240e-01 0.565 0 0
Smooth Muscle Contraction R-HSA-445355 3.078476e-01 0.512 0 0
PLC beta mediated events R-HSA-112043 3.901065e-01 0.409 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.285411e-01 0.483 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.729969e-01 0.564 0 0
Calmodulin induced events R-HSA-111933 3.161033e-01 0.500 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.073481e-01 0.512 0 0
Potassium Channels R-HSA-1296071 2.243207e-01 0.649 0 0
Intra-Golgi traffic R-HSA-6811438 3.904179e-01 0.408 0 0
Metabolism of RNA R-HSA-8953854 2.928963e-01 0.533 0 0
CaM pathway R-HSA-111997 3.161033e-01 0.500 0 0
FLT3 signaling in disease R-HSA-9682385 3.161033e-01 0.500 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.172436e-01 0.663 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.515233e-01 0.454 0 0
Selective autophagy R-HSA-9663891 2.885303e-01 0.540 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.751686e-01 0.560 0 0
Integration of energy metabolism R-HSA-163685 4.045019e-01 0.393 0 0
Cellular response to heat stress R-HSA-3371556 2.828539e-01 0.548 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.172436e-01 0.663 0 0
Formation of the anterior neural plate R-HSA-9823739 2.172436e-01 0.663 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.798365e-01 0.420 0 0
Ca-dependent events R-HSA-111996 4.026511e-01 0.395 0 0
Toll-like Receptor Cascades R-HSA-168898 3.713897e-01 0.430 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.407345e-01 0.618 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.748047e-01 0.561 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.748047e-01 0.561 0 0
Co-inhibition by BTLA R-HSA-9927353 2.748047e-01 0.561 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.073481e-01 0.512 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.340333e-01 0.631 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.681247e-01 0.434 0 0
Regulation of PTEN localization R-HSA-8948747 3.681247e-01 0.434 0 0
RSK activation R-HSA-444257 3.964855e-01 0.402 0 0
Downstream signal transduction R-HSA-186763 2.421588e-01 0.616 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.515233e-01 0.454 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.894662e-01 0.538 0 0
Hemostasis R-HSA-109582 2.177578e-01 0.662 0 0
Signaling by NTRKs R-HSA-166520 2.364207e-01 0.626 0 0
Signaling by ROBO receptors R-HSA-376176 3.241431e-01 0.489 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 2.912671e-01 0.536 0 0
Ub-specific processing proteases R-HSA-5689880 2.710525e-01 0.567 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 3.904179e-01 0.408 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.748047e-01 0.561 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.073481e-01 0.512 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.073481e-01 0.512 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.384331e-01 0.471 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.681247e-01 0.434 0 0
Synthesis of PG R-HSA-1483148 2.508936e-01 0.601 0 0
Degradation of CDH1 R-HSA-9766229 2.673016e-01 0.573 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.543269e-01 0.595 0 0
Signal transduction by L1 R-HSA-445144 3.182899e-01 0.497 0 0
Signaling by PDGF R-HSA-186797 4.003523e-01 0.398 0 0
Interferon alpha/beta signaling R-HSA-909733 3.808094e-01 0.419 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.026511e-01 0.395 0 0
Depyrimidination R-HSA-73928 4.026511e-01 0.395 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.003685e-01 0.522 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.073481e-01 0.512 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.964855e-01 0.402 0 0
Tie2 Signaling R-HSA-210993 2.846692e-01 0.546 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.912671e-01 0.536 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.121578e-01 0.506 0 0
Influenza Infection R-HSA-168255 3.036524e-01 0.518 0 0
Syndecan interactions R-HSA-3000170 3.841788e-01 0.415 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.681247e-01 0.434 0 0
Glucose metabolism R-HSA-70326 2.570962e-01 0.590 0 0
Phospholipid metabolism R-HSA-1483257 2.833451e-01 0.548 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.349678e-01 0.475 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.349678e-01 0.475 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.002405e-01 0.398 0 0
SLC transporter disorders R-HSA-5619102 3.453473e-01 0.462 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.846692e-01 0.546 0 0
Formation of the nephric duct R-HSA-9830364 4.161024e-01 0.381 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.167190e-01 0.380 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.207462e-01 0.376 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.235751e-01 0.373 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.235751e-01 0.373 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.235751e-01 0.373 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.235751e-01 0.373 0 0
ARMS-mediated activation R-HSA-170984 4.235751e-01 0.373 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.235751e-01 0.373 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.235751e-01 0.373 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.235751e-01 0.373 0 0
Interleukin-1 processing R-HSA-448706 4.235751e-01 0.373 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.235751e-01 0.373 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.235751e-01 0.373 0 0
PTEN Regulation R-HSA-6807070 4.251021e-01 0.372 0 0
DAP12 interactions R-HSA-2172127 4.268943e-01 0.370 0 0
Amine ligand-binding receptors R-HSA-375280 4.268943e-01 0.370 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.295611e-01 0.367 0 0
Cellular response to hypoxia R-HSA-1234174 4.308824e-01 0.366 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.317501e-01 0.365 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.317501e-01 0.365 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.317501e-01 0.365 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.317501e-01 0.365 0 0
Abacavir ADME R-HSA-2161522 4.317501e-01 0.365 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.317501e-01 0.365 0 0
DAG and IP3 signaling R-HSA-1489509 4.388868e-01 0.358 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.406338e-01 0.356 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.408111e-01 0.356 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.408111e-01 0.356 0 0
Packaging Of Telomere Ends R-HSA-171306 4.471711e-01 0.350 0 0
Triglyceride biosynthesis R-HSA-75109 4.471711e-01 0.350 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.471711e-01 0.350 0 0
PI3K/AKT activation R-HSA-198203 4.494502e-01 0.347 0 0
Binding and entry of HIV virion R-HSA-173107 4.494502e-01 0.347 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.494502e-01 0.347 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.494502e-01 0.347 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.494502e-01 0.347 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.494502e-01 0.347 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.494502e-01 0.347 0 0
Maturation of spike protein R-HSA-9683686 4.494502e-01 0.347 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.494502e-01 0.347 0 0
Signaling by Leptin R-HSA-2586552 4.494502e-01 0.347 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.507823e-01 0.346 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.507823e-01 0.346 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.507823e-01 0.346 0 0
G-protein mediated events R-HSA-112040 4.510051e-01 0.346 0 0
Peptide chain elongation R-HSA-156902 4.589326e-01 0.338 0 0
Telomere Extension By Telomerase R-HSA-171319 4.623540e-01 0.335 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.623540e-01 0.335 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.623540e-01 0.335 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.625734e-01 0.335 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.726137e-01 0.325 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.741653e-01 0.324 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.741653e-01 0.324 0 0
FGFR2b ligand binding and activation R-HSA-190377 4.741653e-01 0.324 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.741653e-01 0.324 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 4.741653e-01 0.324 0 0
Bicarbonate transporters R-HSA-425381 4.741653e-01 0.324 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 4.741653e-01 0.324 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.741653e-01 0.324 0 0
Suppression of apoptosis R-HSA-9635465 4.741653e-01 0.324 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.741653e-01 0.324 0 0
Platelet degranulation R-HSA-114608 4.764602e-01 0.322 0 0
DARPP-32 events R-HSA-180024 4.772893e-01 0.321 0 0
Signaling by Erythropoietin R-HSA-9006335 4.772893e-01 0.321 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.772893e-01 0.321 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.785494e-01 0.320 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.836979e-01 0.315 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.850852e-01 0.314 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.850852e-01 0.314 0 0
DNA Damage Bypass R-HSA-73893 4.858148e-01 0.314 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.905100e-01 0.309 0 0
Cilium Assembly R-HSA-5617833 4.905310e-01 0.309 0 0
Activation of the pre-replicative complex R-HSA-68962 4.919686e-01 0.308 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.919686e-01 0.308 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.919686e-01 0.308 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.937056e-01 0.307 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.977724e-01 0.303 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 4.977724e-01 0.303 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 4.977724e-01 0.303 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.977724e-01 0.303 0 0
ERKs are inactivated R-HSA-202670 4.977724e-01 0.303 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.977724e-01 0.303 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.977724e-01 0.303 0 0
Sodium/Calcium exchangers R-HSA-425561 4.977724e-01 0.303 0 0
Activation of RAC1 R-HSA-428540 4.977724e-01 0.303 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.977724e-01 0.303 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.002050e-01 0.301 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.011723e-01 0.300 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.022723e-01 0.299 0 0
Membrane Trafficking R-HSA-199991 5.035589e-01 0.298 0 0
Inositol phosphate metabolism R-HSA-1483249 5.038883e-01 0.298 0 0
Reproduction R-HSA-1474165 5.052336e-01 0.297 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.063847e-01 0.296 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.063847e-01 0.296 0 0
HSF1-dependent transactivation R-HSA-3371571 5.085608e-01 0.294 0 0
Signaling by NOTCH4 R-HSA-9013694 5.193487e-01 0.285 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.194236e-01 0.284 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.203210e-01 0.284 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.203210e-01 0.284 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.203210e-01 0.284 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.203210e-01 0.284 0 0
MET activates RAS signaling R-HSA-8851805 5.203210e-01 0.284 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.203210e-01 0.284 0 0
Regulation of IFNG signaling R-HSA-877312 5.203210e-01 0.284 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.203210e-01 0.284 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.203210e-01 0.284 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.203210e-01 0.284 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.203210e-01 0.284 0 0
Estrogen biosynthesis R-HSA-193144 5.203210e-01 0.284 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.205317e-01 0.284 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.205317e-01 0.284 0 0
Neutrophil degranulation R-HSA-6798695 5.241634e-01 0.281 1 1
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.264630e-01 0.279 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.276199e-01 0.278 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.276199e-01 0.278 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.307689e-01 0.275 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.307689e-01 0.275 0 0
Meiotic synapsis R-HSA-1221632 5.307689e-01 0.275 0 0
Signaling by NOTCH R-HSA-157118 5.314700e-01 0.275 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.322372e-01 0.274 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.344048e-01 0.272 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.344048e-01 0.272 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.344048e-01 0.272 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.359426e-01 0.271 0 0
Eukaryotic Translation Termination R-HSA-72764 5.359426e-01 0.271 0 0
PPARA activates gene expression R-HSA-1989781 5.392524e-01 0.268 0 0
G alpha (q) signalling events R-HSA-416476 5.415662e-01 0.266 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.416598e-01 0.266 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.418585e-01 0.266 0 0
FGFR2c ligand binding and activation R-HSA-190375 5.418585e-01 0.266 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.418585e-01 0.266 0 0
FGFR4 ligand binding and activation R-HSA-190322 5.418585e-01 0.266 0 0
Frs2-mediated activation R-HSA-170968 5.418585e-01 0.266 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.418585e-01 0.266 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 5.418585e-01 0.266 0 0
FGFR3 mutant receptor activation R-HSA-2033514 5.418585e-01 0.266 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.418585e-01 0.266 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.418585e-01 0.266 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.480000e-01 0.261 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.492511e-01 0.260 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 5.521574e-01 0.258 0 0
HIV Life Cycle R-HSA-162587 5.521574e-01 0.258 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.604961e-01 0.251 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.604961e-01 0.251 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.604961e-01 0.251 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.604961e-01 0.251 0 0
Regulation of insulin secretion R-HSA-422356 5.604961e-01 0.251 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.613142e-01 0.251 0 0
Signaling by NOTCH2 R-HSA-1980145 5.613142e-01 0.251 0 0
Prolactin receptor signaling R-HSA-1170546 5.624303e-01 0.250 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.624303e-01 0.250 0 0
FGFR3c ligand binding and activation R-HSA-190372 5.624303e-01 0.250 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.624303e-01 0.250 0 0
Physiological factors R-HSA-5578768 5.624303e-01 0.250 0 0
Ciprofloxacin ADME R-HSA-9793528 5.624303e-01 0.250 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.624303e-01 0.250 0 0
P2Y receptors R-HSA-417957 5.624303e-01 0.250 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.624303e-01 0.250 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.629961e-01 0.249 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.629961e-01 0.249 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 5.656112e-01 0.247 0 0
HATs acetylate histones R-HSA-3214847 5.685349e-01 0.245 0 0
Innate Immune System R-HSA-168249 5.695330e-01 0.244 1 0
Hedgehog 'off' state R-HSA-5610787 5.764975e-01 0.239 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.820795e-01 0.235 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 5.820795e-01 0.235 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 5.820795e-01 0.235 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.820795e-01 0.235 0 0
Erythropoietin activates RAS R-HSA-9027284 5.820795e-01 0.235 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.820795e-01 0.235 0 0
DCC mediated attractive signaling R-HSA-418885 5.820795e-01 0.235 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.820795e-01 0.235 0 0
Translesion synthesis by REV1 R-HSA-110312 5.820795e-01 0.235 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.820795e-01 0.235 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.820795e-01 0.235 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.820795e-01 0.235 0 0
FGFR3 ligand binding and activation R-HSA-190239 5.820795e-01 0.235 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 5.820795e-01 0.235 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.820795e-01 0.235 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.837171e-01 0.234 0 0
Selenocysteine synthesis R-HSA-2408557 5.843820e-01 0.233 0 0
Glycosphingolipid transport R-HSA-9845576 5.870921e-01 0.231 0 0
RUNX2 regulates bone development R-HSA-8941326 5.870921e-01 0.231 0 0
Macroautophagy R-HSA-1632852 5.878564e-01 0.231 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.938402e-01 0.226 0 0
Triglyceride metabolism R-HSA-8979227 5.938402e-01 0.226 0 0
Regulation of beta-cell development R-HSA-186712 5.938402e-01 0.226 0 0
Cleavage of the damaged purine R-HSA-110331 5.995536e-01 0.222 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.995536e-01 0.222 0 0
Viral mRNA Translation R-HSA-192823 5.999095e-01 0.222 0 0
MHC class II antigen presentation R-HSA-2132295 6.001217e-01 0.222 0 0
Translesion synthesis by POLI R-HSA-5656121 6.008475e-01 0.221 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.008475e-01 0.221 0 0
Prolonged ERK activation events R-HSA-169893 6.008475e-01 0.221 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.008475e-01 0.221 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.008475e-01 0.221 0 0
Differentiation of T cells R-HSA-9945266 6.008475e-01 0.221 0 0
Activation of SMO R-HSA-5635838 6.008475e-01 0.221 0 0
Negative regulation of FLT3 R-HSA-9706369 6.008475e-01 0.221 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.008475e-01 0.221 0 0
Atorvastatin ADME R-HSA-9754706 6.008475e-01 0.221 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.009571e-01 0.221 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.038022e-01 0.219 0 0
Host Interactions of HIV factors R-HSA-162909 6.071044e-01 0.217 0 0
Opioid Signalling R-HSA-111885 6.075494e-01 0.216 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.093147e-01 0.215 0 0
MET promotes cell motility R-HSA-8875878 6.117297e-01 0.213 0 0
Purine salvage R-HSA-74217 6.117297e-01 0.213 0 0
Depurination R-HSA-73927 6.117297e-01 0.213 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.117297e-01 0.213 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.136014e-01 0.212 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.136014e-01 0.212 0 0
MAP kinase activation R-HSA-450294 6.136014e-01 0.212 0 0
Translesion synthesis by POLK R-HSA-5655862 6.187738e-01 0.208 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.187738e-01 0.208 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.187738e-01 0.208 0 0
Scavenging by Class B Receptors R-HSA-3000471 6.187738e-01 0.208 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.187738e-01 0.208 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.187738e-01 0.208 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.225743e-01 0.206 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.232361e-01 0.205 0 0
GPCR downstream signalling R-HSA-388396 6.232478e-01 0.205 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.236210e-01 0.205 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.236210e-01 0.205 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.327053e-01 0.199 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.342013e-01 0.198 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.352284e-01 0.197 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.352284e-01 0.197 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.358960e-01 0.197 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.358960e-01 0.197 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.358960e-01 0.197 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.358960e-01 0.197 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.358960e-01 0.197 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.358960e-01 0.197 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.372510e-01 0.196 0 0
tRNA processing R-HSA-72306 6.377583e-01 0.195 0 0
SARS-CoV Infections R-HSA-9679506 6.392531e-01 0.194 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.422655e-01 0.192 0 0
G alpha (s) signalling events R-HSA-418555 6.435139e-01 0.191 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.444561e-01 0.191 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.444561e-01 0.191 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.444561e-01 0.191 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.444561e-01 0.191 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 6.465536e-01 0.189 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.465536e-01 0.189 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.465536e-01 0.189 0 0
Maturation of spike protein R-HSA-9694548 6.465536e-01 0.189 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.515709e-01 0.186 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.522502e-01 0.186 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.522502e-01 0.186 0 0
Activated point mutants of FGFR2 R-HSA-2033519 6.522502e-01 0.186 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.522502e-01 0.186 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.522502e-01 0.186 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.522502e-01 0.186 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.522502e-01 0.186 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.522502e-01 0.186 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.522502e-01 0.186 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 6.522502e-01 0.186 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.575983e-01 0.182 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.575983e-01 0.182 0 0
ER-Phagosome pathway R-HSA-1236974 6.580409e-01 0.182 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.585948e-01 0.181 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.585948e-01 0.181 0 0
Signaling by GPCR R-HSA-372790 6.675528e-01 0.176 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.678708e-01 0.175 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.678708e-01 0.175 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.678708e-01 0.175 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.678708e-01 0.175 0 0
Regulation of signaling by CBL R-HSA-912631 6.678708e-01 0.175 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.678708e-01 0.175 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.678708e-01 0.175 0 0
Other interleukin signaling R-HSA-449836 6.678708e-01 0.175 0 0
The NLRP3 inflammasome R-HSA-844456 6.678708e-01 0.175 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.678708e-01 0.175 0 0
Activation of GABAB receptors R-HSA-991365 6.683651e-01 0.175 0 0
GABA B receptor activation R-HSA-977444 6.683651e-01 0.175 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.683651e-01 0.175 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 6.683651e-01 0.175 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.683651e-01 0.175 0 0
DNA Double Strand Break Response R-HSA-5693606 6.689118e-01 0.175 0 0
Interferon Signaling R-HSA-913531 6.738797e-01 0.171 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.788564e-01 0.168 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.791139e-01 0.168 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.791139e-01 0.168 0 0
IRE1alpha activates chaperones R-HSA-381070 6.808109e-01 0.167 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 6.827906e-01 0.166 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.827906e-01 0.166 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.827906e-01 0.166 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.827906e-01 0.166 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.827906e-01 0.166 0 0
Protein hydroxylation R-HSA-9629569 6.827906e-01 0.166 0 0
Signaling by NODAL R-HSA-1181150 6.827906e-01 0.166 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.857674e-01 0.164 0 0
Autophagy R-HSA-9612973 6.861398e-01 0.164 0 0
Protein folding R-HSA-391251 6.881608e-01 0.162 0 0
HCMV Late Events R-HSA-9610379 6.917563e-01 0.160 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.923272e-01 0.160 0 0
Interleukin-17 signaling R-HSA-448424 6.943066e-01 0.158 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.970411e-01 0.157 0 0
FGFR2 ligand binding and activation R-HSA-190241 6.970411e-01 0.157 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.970411e-01 0.157 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.970411e-01 0.157 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.970411e-01 0.157 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.970411e-01 0.157 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.970411e-01 0.157 0 0
ERK/MAPK targets R-HSA-198753 6.970411e-01 0.157 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.970411e-01 0.157 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.970411e-01 0.157 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.970411e-01 0.157 0 0
Cellular response to starvation R-HSA-9711097 6.973076e-01 0.157 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.987929e-01 0.156 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.990253e-01 0.156 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.990253e-01 0.156 0 0
Nucleosome assembly R-HSA-774815 6.990253e-01 0.156 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.990253e-01 0.156 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.990253e-01 0.156 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.990253e-01 0.156 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.024375e-01 0.153 0 0
Hedgehog 'on' state R-HSA-5632684 7.024375e-01 0.153 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 7.051643e-01 0.152 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.051643e-01 0.152 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.064201e-01 0.151 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.087097e-01 0.150 0 0
Regulation of pyruvate metabolism R-HSA-9861718 7.087097e-01 0.150 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.087097e-01 0.150 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.090585e-01 0.149 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.106522e-01 0.148 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.106522e-01 0.148 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.106522e-01 0.148 0 0
Glutathione synthesis and recycling R-HSA-174403 7.106522e-01 0.148 0 0
Ribavirin ADME R-HSA-9755088 7.106522e-01 0.148 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.114412e-01 0.148 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.114412e-01 0.148 0 0
Signaling by Hedgehog R-HSA-5358351 7.147867e-01 0.146 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.181324e-01 0.144 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.182027e-01 0.144 0 0
rRNA processing R-HSA-72312 7.194839e-01 0.143 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 7.231040e-01 0.141 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.236526e-01 0.140 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.236526e-01 0.140 0 0
FGFR2 alternative splicing R-HSA-6803529 7.236526e-01 0.140 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.236526e-01 0.140 0 0
Notch-HLH transcription pathway R-HSA-350054 7.236526e-01 0.140 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.236526e-01 0.140 0 0
Signaling by KIT in disease R-HSA-9669938 7.236526e-01 0.140 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.236526e-01 0.140 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.236526e-01 0.140 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.236526e-01 0.140 0 0
Homology Directed Repair R-HSA-5693538 7.237112e-01 0.140 0 0
Selenoamino acid metabolism R-HSA-2408522 7.292315e-01 0.137 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.333121e-01 0.135 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.360696e-01 0.133 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.360696e-01 0.133 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.360696e-01 0.133 0 0
Ion channel transport R-HSA-983712 7.377285e-01 0.132 0 0
UCH proteinases R-HSA-5689603 7.406240e-01 0.130 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.448701e-01 0.128 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.477758e-01 0.126 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.479294e-01 0.126 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.479294e-01 0.126 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.479294e-01 0.126 0 0
Deadenylation of mRNA R-HSA-429947 7.479294e-01 0.126 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.479294e-01 0.126 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.479294e-01 0.126 0 0
Complex III assembly R-HSA-9865881 7.479294e-01 0.126 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.479294e-01 0.126 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.532869e-01 0.123 0 0
The phototransduction cascade R-HSA-2514856 7.532869e-01 0.123 0 0
Integrin cell surface interactions R-HSA-216083 7.547690e-01 0.122 0 0
Interleukin-1 signaling R-HSA-9020702 7.550570e-01 0.122 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.592570e-01 0.120 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.592570e-01 0.120 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.592570e-01 0.120 0 0
G protein gated Potassium channels R-HSA-1296059 7.592570e-01 0.120 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.592570e-01 0.120 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.592570e-01 0.120 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.592570e-01 0.120 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.592570e-01 0.120 0 0
Interleukin-7 signaling R-HSA-1266695 7.592570e-01 0.120 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.614632e-01 0.118 0 0
Neurexins and neuroligins R-HSA-6794361 7.614632e-01 0.118 0 0
Orc1 removal from chromatin R-HSA-68949 7.614632e-01 0.118 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.614632e-01 0.118 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.614632e-01 0.118 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.614632e-01 0.118 0 0
Signaling by MET R-HSA-6806834 7.682864e-01 0.114 0 0
HCMV Early Events R-HSA-9609690 7.693445e-01 0.114 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.694037e-01 0.114 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.694037e-01 0.114 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.694037e-01 0.114 0 0
MET activates PTK2 signaling R-HSA-8874081 7.700762e-01 0.113 0 0
Metalloprotease DUBs R-HSA-5689901 7.700762e-01 0.113 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.700762e-01 0.113 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.742705e-01 0.111 0 0
Translation initiation complex formation R-HSA-72649 7.771130e-01 0.110 0 0
RSV-host interactions R-HSA-9833110 7.785129e-01 0.109 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.804098e-01 0.108 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.804098e-01 0.108 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.804098e-01 0.108 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.804098e-01 0.108 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.804098e-01 0.108 0 0
Cristae formation R-HSA-8949613 7.804098e-01 0.108 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.804098e-01 0.108 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.804098e-01 0.108 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.804098e-01 0.108 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.804098e-01 0.108 0 0
Signaling by BMP R-HSA-201451 7.804098e-01 0.108 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.804098e-01 0.108 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.812524e-01 0.107 0 0
HDACs deacetylate histones R-HSA-3214815 7.845958e-01 0.105 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.845958e-01 0.105 0 0
G alpha (z) signalling events R-HSA-418597 7.845958e-01 0.105 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.902796e-01 0.102 0 0
HIV elongation arrest and recovery R-HSA-167287 7.902796e-01 0.102 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.902796e-01 0.102 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.902796e-01 0.102 0 0
Insulin receptor recycling R-HSA-77387 7.902796e-01 0.102 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.902796e-01 0.102 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.902796e-01 0.102 0 0
Prednisone ADME R-HSA-9757110 7.902796e-01 0.102 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.902796e-01 0.102 0 0
Inflammasomes R-HSA-622312 7.902796e-01 0.102 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 7.913754e-01 0.102 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 7.918570e-01 0.101 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.958677e-01 0.099 0 0
HIV Infection R-HSA-162906 7.985156e-01 0.098 0 0
Synthesis of PA R-HSA-1483166 7.989012e-01 0.098 0 0
Meiosis R-HSA-1500620 7.994294e-01 0.097 0 0
DNA methylation R-HSA-5334118 7.997063e-01 0.097 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.997063e-01 0.097 0 0
Thyroxine biosynthesis R-HSA-209968 7.997063e-01 0.097 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 7.997063e-01 0.097 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.997063e-01 0.097 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.997063e-01 0.097 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 7.997063e-01 0.097 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.997063e-01 0.097 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.997063e-01 0.097 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.057334e-01 0.094 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.087099e-01 0.092 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.087099e-01 0.092 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.087099e-01 0.092 0 0
Neurotransmitter clearance R-HSA-112311 8.087099e-01 0.092 0 0
Extension of Telomeres R-HSA-180786 8.123584e-01 0.090 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.123584e-01 0.090 0 0
Pyruvate metabolism R-HSA-70268 8.163782e-01 0.088 0 0
Budding and maturation of HIV virion R-HSA-162588 8.173092e-01 0.088 0 0
Cargo concentration in the ER R-HSA-5694530 8.173092e-01 0.088 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.173092e-01 0.088 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.173092e-01 0.088 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 8.173092e-01 0.088 0 0
GABA receptor activation R-HSA-977443 8.187809e-01 0.087 0 0
tRNA Aminoacylation R-HSA-379724 8.187809e-01 0.087 0 0
Interferon gamma signaling R-HSA-877300 8.212710e-01 0.086 0 0
Aquaporin-mediated transport R-HSA-445717 8.250058e-01 0.084 0 0
Nucleotide salvage R-HSA-8956321 8.250058e-01 0.084 0 0
Collagen degradation R-HSA-1442490 8.250058e-01 0.084 0 0
DNA Repair R-HSA-73894 8.296807e-01 0.081 0 0
Heme signaling R-HSA-9707616 8.310378e-01 0.080 0 0
Mitochondrial protein import R-HSA-1268020 8.310378e-01 0.080 0 0
Base Excision Repair R-HSA-73884 8.320957e-01 0.080 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.333670e-01 0.079 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.333670e-01 0.079 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.333670e-01 0.079 0 0
Cardiogenesis R-HSA-9733709 8.333670e-01 0.079 0 0
Ribosome-associated quality control R-HSA-9948299 8.383989e-01 0.077 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.408593e-01 0.075 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.408593e-01 0.075 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.408593e-01 0.075 0 0
Heme degradation R-HSA-189483 8.408593e-01 0.075 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.423462e-01 0.075 0 0
CD22 mediated BCR regulation R-HSA-5690714 8.425423e-01 0.074 0 0
eNOS activation R-HSA-203615 8.480151e-01 0.072 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.480151e-01 0.072 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.480151e-01 0.072 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.480151e-01 0.072 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.480151e-01 0.072 0 0
Signal amplification R-HSA-392518 8.480151e-01 0.072 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.480151e-01 0.072 0 0
FCGR activation R-HSA-2029481 8.512436e-01 0.070 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.533318e-01 0.069 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.548255e-01 0.068 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.548496e-01 0.068 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.548496e-01 0.068 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.548496e-01 0.068 0 0
PERK regulates gene expression R-HSA-381042 8.548496e-01 0.068 0 0
Kidney development R-HSA-9830369 8.584699e-01 0.066 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.609078e-01 0.065 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.613772e-01 0.065 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.613772e-01 0.065 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.613772e-01 0.065 0 0
HSF1 activation R-HSA-3371511 8.613772e-01 0.065 0 0
Triglyceride catabolism R-HSA-163560 8.613772e-01 0.065 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.613772e-01 0.065 0 0
Vesicle-mediated transport R-HSA-5653656 8.633554e-01 0.064 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.643294e-01 0.063 0 0
Chromosome Maintenance R-HSA-73886 8.664866e-01 0.062 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.676115e-01 0.062 0 0
Degradation of DVL R-HSA-4641258 8.676115e-01 0.062 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.676115e-01 0.062 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.684609e-01 0.061 0 0
Telomere Maintenance R-HSA-157579 8.724810e-01 0.059 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.735659e-01 0.059 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.735659e-01 0.059 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.735659e-01 0.059 0 0
Elastic fibre formation R-HSA-1566948 8.735659e-01 0.059 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.735659e-01 0.059 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.738629e-01 0.059 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.738629e-01 0.059 0 0
Formation of the cornified envelope R-HSA-6809371 8.772144e-01 0.057 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.792528e-01 0.056 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.792528e-01 0.056 0 0
Pentose phosphate pathway R-HSA-71336 8.792528e-01 0.056 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.792528e-01 0.056 0 0
Stabilization of p53 R-HSA-69541 8.792528e-01 0.056 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.792528e-01 0.056 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.817729e-01 0.055 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.817729e-01 0.055 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.817729e-01 0.055 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.817729e-01 0.055 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 8.829694e-01 0.054 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.846842e-01 0.053 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.846842e-01 0.053 0 0
HIV Transcription Elongation R-HSA-167169 8.846842e-01 0.053 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.846842e-01 0.053 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.846842e-01 0.053 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.898717e-01 0.051 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.898717e-01 0.051 0 0
Signaling by FGFR in disease R-HSA-1226099 8.900598e-01 0.051 0 0
ROS and RNS production in phagocytes R-HSA-1222556 8.900598e-01 0.051 0 0
DNA Replication R-HSA-69306 8.925643e-01 0.049 0 0
Protein ubiquitination R-HSA-8852135 8.939982e-01 0.049 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.948261e-01 0.048 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.948261e-01 0.048 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.948261e-01 0.048 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.948261e-01 0.048 0 0
Translation of Structural Proteins R-HSA-9683701 8.948261e-01 0.048 0 0
Heme biosynthesis R-HSA-189451 8.948261e-01 0.048 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.976968e-01 0.047 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.978050e-01 0.047 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.995578e-01 0.046 0 0
Translation of Structural Proteins R-HSA-9694635 9.014843e-01 0.045 0 0
Nucleotide Excision Repair R-HSA-5696398 9.040283e-01 0.044 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.040770e-01 0.044 0 0
Disease R-HSA-1643685 9.041945e-01 0.044 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 9.050396e-01 0.043 0 0
RNA Polymerase I Transcription R-HSA-73864 9.050396e-01 0.043 0 0
Cholesterol biosynthesis R-HSA-191273 9.050396e-01 0.043 0 0
Interleukin-10 signaling R-HSA-6783783 9.050396e-01 0.043 0 0
Circadian clock R-HSA-9909396 9.077510e-01 0.042 0 0
RMTs methylate histone arginines R-HSA-3214858 9.083931e-01 0.042 0 0
Surfactant metabolism R-HSA-5683826 9.083931e-01 0.042 0 0
Synthesis of DNA R-HSA-69239 9.100037e-01 0.041 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.125153e-01 0.040 0 0
Somitogenesis R-HSA-9824272 9.125153e-01 0.040 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 9.125153e-01 0.040 0 0
Amyloid fiber formation R-HSA-977225 9.149990e-01 0.039 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.156397e-01 0.038 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.164522e-01 0.038 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.164522e-01 0.038 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.164522e-01 0.038 0 0
Diseases of DNA repair R-HSA-9675135 9.164522e-01 0.038 0 0
TCR signaling R-HSA-202403 9.183355e-01 0.037 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.202122e-01 0.036 0 0
Synthesis of PC R-HSA-1483191 9.202122e-01 0.036 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.202122e-01 0.036 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.210848e-01 0.036 0 0
Post-translational protein modification R-HSA-597592 9.210892e-01 0.036 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.234928e-01 0.035 0 0
Intraflagellar transport R-HSA-5620924 9.238031e-01 0.034 0 0
NGF-stimulated transcription R-HSA-9031628 9.238031e-01 0.034 0 0
Metal ion SLC transporters R-HSA-425410 9.238031e-01 0.034 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.239716e-01 0.034 0 0
Neddylation R-HSA-8951664 9.253341e-01 0.034 0 0
Gap junction trafficking and regulation R-HSA-157858 9.272327e-01 0.033 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.272327e-01 0.033 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.272327e-01 0.033 0 0
HCMV Infection R-HSA-9609646 9.279073e-01 0.032 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.290041e-01 0.032 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.294492e-01 0.032 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.305081e-01 0.031 0 0
Meiotic recombination R-HSA-912446 9.336363e-01 0.030 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.336363e-01 0.030 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.336363e-01 0.030 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.366238e-01 0.028 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.366238e-01 0.028 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.366238e-01 0.028 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.369709e-01 0.028 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.391597e-01 0.027 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.394770e-01 0.027 0 0
Downstream TCR signaling R-HSA-202424 9.415561e-01 0.026 0 0
Neurotransmitter release cycle R-HSA-112310 9.415561e-01 0.026 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.422019e-01 0.026 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.444741e-01 0.025 0 0
Paracetamol ADME R-HSA-9753281 9.448043e-01 0.025 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.472897e-01 0.024 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.472897e-01 0.024 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.472897e-01 0.024 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.478439e-01 0.023 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.478439e-01 0.023 0 0
Potential therapeutics for SARS R-HSA-9679191 9.493613e-01 0.023 0 0
Dectin-2 family R-HSA-5621480 9.496633e-01 0.022 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.497927e-01 0.022 0 0
Dual incision in TC-NER R-HSA-6782135 9.519302e-01 0.021 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.519302e-01 0.021 0 0
Protein localization R-HSA-9609507 9.538513e-01 0.021 0 0
Peroxisomal protein import R-HSA-9033241 9.540951e-01 0.020 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.561626e-01 0.019 0 0
Glutathione conjugation R-HSA-156590 9.561626e-01 0.019 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.561626e-01 0.019 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.561626e-01 0.019 0 0
G alpha (i) signalling events R-HSA-418594 9.562639e-01 0.019 0 0
Endogenous sterols R-HSA-211976 9.581371e-01 0.019 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.600229e-01 0.018 0 0
Extracellular matrix organization R-HSA-1474244 9.605233e-01 0.017 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.618237e-01 0.017 0 0
Ion transport by P-type ATPases R-HSA-936837 9.635436e-01 0.016 0 0
Xenobiotics R-HSA-211981 9.635436e-01 0.016 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.658134e-01 0.015 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.659256e-01 0.015 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.670436e-01 0.015 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.682526e-01 0.014 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.682526e-01 0.014 0 0
Metabolism of steroid hormones R-HSA-196071 9.682526e-01 0.014 0 0
Transcription of the HIV genome R-HSA-167172 9.696832e-01 0.013 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.696832e-01 0.013 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.696832e-01 0.013 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.723541e-01 0.012 0 0
COPII-mediated vesicle transport R-HSA-204005 9.723541e-01 0.012 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.736001e-01 0.012 0 0
ECM proteoglycans R-HSA-3000178 9.736001e-01 0.012 0 0
Metabolism of cofactors R-HSA-8978934 9.736001e-01 0.012 0 0
Metabolism of porphyrins R-HSA-189445 9.736001e-01 0.012 0 0
Purine catabolism R-HSA-74259 9.747900e-01 0.011 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.770116e-01 0.010 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.776493e-01 0.010 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.780479e-01 0.010 0 0
Iron uptake and transport R-HSA-917937 9.780479e-01 0.010 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.780479e-01 0.010 0 0
PCP/CE pathway R-HSA-4086400 9.808852e-01 0.008 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.817472e-01 0.008 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.817472e-01 0.008 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.825703e-01 0.008 0 0
Mitochondrial biogenesis R-HSA-1592230 9.831236e-01 0.007 0 0
Peptide hormone metabolism R-HSA-2980736 9.831236e-01 0.007 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.833563e-01 0.007 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.848237e-01 0.007 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.855083e-01 0.006 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.856046e-01 0.006 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.867083e-01 0.006 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.873823e-01 0.006 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.910206e-01 0.004 0 0
Sensory perception of taste R-HSA-9717189 9.911020e-01 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 9.916730e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.916730e-01 0.004 0 0
Viral Infection Pathways R-HSA-9824446 9.922080e-01 0.003 0 0
Keratinization R-HSA-6805567 9.924367e-01 0.003 0 0
Mitochondrial translation elongation R-HSA-5389840 9.927506e-01 0.003 0 0
Mitochondrial translation initiation R-HSA-5368286 9.933905e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.939739e-01 0.003 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.947541e-01 0.002 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.952173e-01 0.002 0 0
Visual phototransduction R-HSA-2187338 9.957192e-01 0.002 0 0
Mitochondrial translation termination R-HSA-5419276 9.962044e-01 0.002 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.965515e-01 0.002 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.972541e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.973645e-01 0.001 0 0
Regulation of Complement cascade R-HSA-977606 9.983495e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.986736e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.986906e-01 0.001 0 0
Drug ADME R-HSA-9748784 9.987779e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.991865e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.992133e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.993176e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.994431e-01 0.000 0 0
Complement cascade R-HSA-166658 9.994571e-01 0.000 0 0
Translation R-HSA-72766 9.995614e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.995694e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.995725e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.998043e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.998070e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.998744e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.998839e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998879e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999319e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999488e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999615e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999849e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999892e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999929e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999937e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999994e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999998e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
M Phase R-HSA-68886 4.522662e-10 9.345 0 0
Cell-Cell communication R-HSA-1500931 1.231109e-09 8.910 0 0
Cell Cycle R-HSA-1640170 2.003600e-09 8.698 0 0
Cell Cycle, Mitotic R-HSA-69278 2.003034e-08 7.698 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.958379e-08 7.529 0 0
Apoptotic execution phase R-HSA-75153 3.465924e-08 7.460 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.517275e-08 7.258 0 0
Cell junction organization R-HSA-446728 1.115459e-07 6.953 0 0
Cell Cycle Checkpoints R-HSA-69620 1.900653e-07 6.721 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.594282e-07 6.586 0 0
Mitotic Prophase R-HSA-68875 2.665045e-07 6.574 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.680692e-07 6.572 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.900742e-07 6.409 0 0
G2/M Checkpoints R-HSA-69481 6.888840e-07 6.162 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.130428e-07 6.090 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 8.452000e-07 6.073 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 8.452000e-07 6.073 0 0
Recycling pathway of L1 R-HSA-437239 1.647083e-06 5.783 0 0
Mitotic Prometaphase R-HSA-68877 1.634538e-06 5.787 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.112935e-06 5.675 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.272232e-06 5.644 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.431416e-06 5.614 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.724432e-06 5.565 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.162787e-06 5.500 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.220831e-06 5.492 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.280586e-06 5.484 0 0
Mitotic Anaphase R-HSA-68882 3.959601e-06 5.402 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.278642e-06 5.369 0 0
Meiotic synapsis R-HSA-1221632 4.981580e-06 5.303 0 0
Adherens junctions interactions R-HSA-418990 4.621095e-06 5.335 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.262300e-06 5.083 0 0
DNA Double Strand Break Response R-HSA-5693606 9.596178e-06 5.018 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.031187e-05 4.987 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.031187e-05 4.987 0 0
Aggrephagy R-HSA-9646399 1.121312e-05 4.950 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.136730e-05 4.944 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.358906e-05 4.867 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.358906e-05 4.867 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.293350e-05 4.888 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.365950e-05 4.865 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.463268e-05 4.835 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.547508e-05 4.810 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.787385e-05 4.748 0 0
Cell-cell junction organization R-HSA-421270 1.798239e-05 4.745 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.972056e-05 4.705 0 0
Packaging Of Telomere Ends R-HSA-171306 2.164192e-05 4.665 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.009741e-05 4.697 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.140664e-05 4.669 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.164192e-05 4.665 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.476160e-05 4.606 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.514960e-05 4.599 0 0
Meiosis R-HSA-1500620 2.514960e-05 4.599 0 0
DNA methylation R-HSA-5334118 3.400964e-05 4.468 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.400964e-05 4.468 0 0
Nucleosome assembly R-HSA-774815 3.319544e-05 4.479 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.319544e-05 4.479 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.190541e-05 4.496 0 0
Separation of Sister Chromatids R-HSA-2467813 3.182089e-05 4.497 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.553618e-05 4.449 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.590823e-05 4.445 0 0
Homology Directed Repair R-HSA-5693538 3.644699e-05 4.438 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.920066e-05 4.407 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.030149e-05 4.395 0 0
Cellular responses to stimuli R-HSA-8953897 4.618068e-05 4.336 0 0
HCMV Early Events R-HSA-9609690 4.897247e-05 4.310 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.687903e-05 4.245 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.112846e-05 4.214 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.112846e-05 4.214 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.347125e-05 4.197 0 0
Protein folding R-HSA-391251 7.012899e-05 4.154 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.020052e-05 4.154 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.945601e-05 4.100 0 0
Cellular responses to stress R-HSA-2262752 7.952025e-05 4.100 0 0
Meiotic recombination R-HSA-912446 8.531171e-05 4.069 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.975021e-05 4.047 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.009589e-04 3.996 0 0
Depyrimidination R-HSA-73928 1.009589e-04 3.996 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.106523e-04 3.956 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.138428e-04 3.944 0 0
DNA Repair R-HSA-73894 1.196990e-04 3.922 0 0
Cellular Senescence R-HSA-2559583 1.138558e-04 3.944 0 0
ESR-mediated signaling R-HSA-8939211 1.167869e-04 3.933 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.368285e-04 3.864 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.368285e-04 3.864 0 0
HDACs deacetylate histones R-HSA-3214815 1.500464e-04 3.824 0 0
Cellular response to heat stress R-HSA-3371556 1.518236e-04 3.819 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.591423e-04 3.798 0 0
HSF1 activation R-HSA-3371511 1.591423e-04 3.798 0 0
Cleavage of the damaged purine R-HSA-110331 1.883111e-04 3.725 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.915666e-04 3.718 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.997769e-04 3.699 0 0
Metabolism of RNA R-HSA-8953854 2.168270e-04 3.664 0 0
Depurination R-HSA-73927 2.217965e-04 3.654 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.418117e-04 3.617 0 0
Chromatin organization R-HSA-4839726 2.347304e-04 3.629 0 0
Chromatin modifying enzymes R-HSA-3247509 2.355124e-04 3.628 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.708743e-04 3.567 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.941253e-04 3.531 0 0
L1CAM interactions R-HSA-373760 3.008360e-04 3.522 0 0
Attenuation phase R-HSA-3371568 3.036879e-04 3.518 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.039351e-04 3.517 0 0
Nervous system development R-HSA-9675108 3.174382e-04 3.498 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.504477e-04 3.455 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.635066e-04 3.439 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.635066e-04 3.439 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.236387e-04 3.373 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.236387e-04 3.373 0 0
HATs acetylate histones R-HSA-3214847 5.075969e-04 3.294 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.075341e-04 3.295 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.264259e-04 3.279 0 0
Defective pyroptosis R-HSA-9710421 5.429820e-04 3.265 0 0
Axon guidance R-HSA-422475 5.353143e-04 3.271 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.441165e-04 3.264 0 0
Apoptosis R-HSA-109581 5.634111e-04 3.249 0 0
RNA Polymerase I Transcription R-HSA-73864 5.697465e-04 3.244 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.729177e-04 3.242 0 0
Transport of connexons to the plasma membrane R-HSA-190872 6.386572e-04 3.195 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.568747e-04 3.183 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.940448e-04 3.159 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.105352e-04 3.148 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.050095e-04 3.094 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.050095e-04 3.094 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 8.050095e-04 3.094 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.050095e-04 3.094 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.050095e-04 3.094 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.050095e-04 3.094 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.050095e-04 3.094 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.050095e-04 3.094 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.050095e-04 3.094 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.050095e-04 3.094 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.050095e-04 3.094 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.050095e-04 3.094 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.143851e-04 3.089 0 0
HIV Infection R-HSA-162906 8.585950e-04 3.066 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.737813e-04 3.059 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.737813e-04 3.059 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.011438e-04 3.045 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.784235e-04 3.009 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.155039e-03 2.937 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.145303e-03 2.941 0 0
Gene Silencing by RNA R-HSA-211000 1.068789e-03 2.971 0 0
HCMV Infection R-HSA-9609646 1.244233e-03 2.905 0 0
Programmed Cell Death R-HSA-5357801 1.373004e-03 2.862 0 0
HSF1-dependent transactivation R-HSA-3371571 1.482315e-03 2.829 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.521707e-03 2.818 0 0
Host Interactions of HIV factors R-HSA-162909 1.557953e-03 2.807 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.564376e-03 2.806 0 0
Selective autophagy R-HSA-9663891 1.569177e-03 2.804 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.668874e-03 2.778 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.763454e-03 2.754 0 0
MAP2K and MAPK activation R-HSA-5674135 1.763454e-03 2.754 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.763454e-03 2.754 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.874897e-03 2.727 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.923245e-03 2.716 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.995602e-03 2.700 0 0
Striated Muscle Contraction R-HSA-390522 2.295236e-03 2.639 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.295389e-03 2.639 0 0
PKR-mediated signaling R-HSA-9833482 2.233865e-03 2.651 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.072585e-03 2.683 0 0
G2/M Transition R-HSA-69275 2.445656e-03 2.612 0 0
Signaling by WNT R-HSA-195721 2.490797e-03 2.604 0 0
HIV Life Cycle R-HSA-162587 2.527310e-03 2.597 0 0
Gap junction trafficking R-HSA-190828 2.532325e-03 2.596 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.532325e-03 2.596 0 0
Signaling by ROBO receptors R-HSA-376176 2.625553e-03 2.581 0 0
Reproduction R-HSA-1474165 2.642784e-03 2.578 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.646648e-03 2.577 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.714863e-03 2.566 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.817249e-03 2.550 0 0
Regulation of CDH1 Function R-HSA-9764561 2.817249e-03 2.550 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.853411e-03 2.545 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.853411e-03 2.545 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.867445e-03 2.543 0 0
Viral Infection Pathways R-HSA-9824446 3.014578e-03 2.521 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.682372e-03 2.434 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.175609e-03 2.498 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.175609e-03 2.498 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.175609e-03 2.498 0 0
Signaling by RAS mutants R-HSA-6802949 3.175609e-03 2.498 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.191952e-03 2.496 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.446590e-03 2.463 0 0
Chromosome Maintenance R-HSA-73886 3.324272e-03 2.478 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.472589e-03 2.459 0 0
Telomere Maintenance R-HSA-157579 3.706309e-03 2.431 0 0
MHC class II antigen presentation R-HSA-2132295 3.775091e-03 2.423 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.783551e-03 2.422 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.853402e-03 2.414 0 0
Membrane Trafficking R-HSA-199991 4.132827e-03 2.384 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.179544e-03 2.379 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.179544e-03 2.379 0 0
Gap junction trafficking and regulation R-HSA-157858 4.370518e-03 2.359 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.450650e-03 2.352 0 0
Protein ubiquitination R-HSA-8852135 4.471434e-03 2.350 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.471434e-03 2.350 0 0
Diseases of programmed cell death R-HSA-9645723 4.599676e-03 2.337 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.663057e-03 2.331 0 0
DNA Replication R-HSA-69306 4.728014e-03 2.325 0 0
Integration of provirus R-HSA-162592 4.744333e-03 2.324 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.961286e-03 2.304 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.961286e-03 2.304 0 0
Base Excision Repair R-HSA-73884 5.328894e-03 2.273 0 0
Neutrophil degranulation R-HSA-6798695 5.347349e-03 2.272 1 1
Interactions of Vpr with host cellular proteins R-HSA-176033 5.469471e-03 2.262 0 0
Nephrin family interactions R-HSA-373753 5.499177e-03 2.260 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.653075e-03 2.248 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.338401e-03 2.198 0 0
AURKA Activation by TPX2 R-HSA-8854518 6.424143e-03 2.192 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.682722e-03 2.114 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.485795e-03 2.188 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.738467e-03 2.111 0 0
Signaling by ALK in cancer R-HSA-9700206 7.738467e-03 2.111 0 0
Signaling by NOTCH R-HSA-157118 7.014949e-03 2.154 0 0
Amyloid fiber formation R-HSA-977225 7.138681e-03 2.146 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.792416e-03 2.108 0 0
Breakdown of the nuclear lamina R-HSA-352238 8.047502e-03 2.094 0 0
Influenza Infection R-HSA-168255 8.272558e-03 2.082 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.449683e-03 2.073 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.485835e-03 2.071 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.875962e-03 2.052 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.007065e-02 1.997 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.018463e-02 1.992 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.018463e-02 1.992 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.032113e-02 1.986 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.034922e-02 1.985 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.060787e-02 1.974 0 0
Gap junction assembly R-HSA-190861 1.060787e-02 1.974 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.064865e-02 1.973 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.094076e-02 1.961 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.111345e-02 1.954 0 0
Deadenylation of mRNA R-HSA-429947 1.145978e-02 1.941 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.181192e-02 1.928 0 0
Kinesins R-HSA-983189 1.186521e-02 1.926 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.195048e-02 1.923 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.233778e-02 1.909 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.259921e-02 1.900 0 0
Centrosome maturation R-HSA-380287 1.283367e-02 1.892 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.333772e-02 1.875 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.333772e-02 1.875 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.348733e-02 1.870 0 0
Interferon Signaling R-HSA-913531 1.471579e-02 1.832 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.484369e-02 1.828 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.500218e-02 1.824 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.504191e-02 1.823 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.660200e-02 1.780 0 0
mRNA 3'-end processing R-HSA-72187 1.870294e-02 1.728 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.599516e-02 1.796 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.937863e-02 1.713 0 0
Unwinding of DNA R-HSA-176974 1.676783e-02 1.776 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.995548e-02 1.700 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.765791e-02 1.753 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.676783e-02 1.776 0 0
Developmental Biology R-HSA-1266738 1.923958e-02 1.716 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.995548e-02 1.700 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.736764e-02 1.760 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.003438e-02 1.698 0 0
Smooth Muscle Contraction R-HSA-445355 2.024072e-02 1.694 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.064555e-02 1.685 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.064555e-02 1.685 0 0
2-LTR circle formation R-HSA-164843 2.064555e-02 1.685 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.076132e-02 1.683 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.109611e-02 1.676 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.109611e-02 1.676 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.130002e-02 1.672 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.143805e-02 1.669 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.144546e-02 1.669 0 0
Translation initiation complex formation R-HSA-72649 2.186449e-02 1.660 0 0
Ribosome-associated quality control R-HSA-9948299 2.274934e-02 1.643 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.309409e-02 1.636 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.342327e-02 1.630 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.421574e-02 1.616 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.537826e-02 1.596 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.603157e-02 1.584 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.603157e-02 1.584 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.614117e-02 1.583 0 0
Cilium Assembly R-HSA-5617833 2.625887e-02 1.581 0 0
Ub-specific processing proteases R-HSA-5689880 2.638863e-02 1.579 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.789280e-02 1.555 0 0
Glycolysis R-HSA-70171 2.813534e-02 1.551 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.827935e-02 1.549 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.833481e-02 1.548 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.851505e-02 1.545 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.926274e-02 1.534 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 2.944203e-02 1.531 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.944203e-02 1.531 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.951604e-02 1.530 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.975082e-02 1.527 0 0
Peptide chain elongation R-HSA-156902 3.082775e-02 1.511 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.101053e-02 1.508 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.101053e-02 1.508 0 0
Metabolism of non-coding RNA R-HSA-194441 3.134318e-02 1.504 0 0
snRNP Assembly R-HSA-191859 3.134318e-02 1.504 0 0
Signal Transduction R-HSA-162582 3.145162e-02 1.502 1 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.903847e-02 1.409 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.497447e-02 1.456 0 0
Disorders of Nervous System Development R-HSA-9697154 3.497447e-02 1.456 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.497447e-02 1.456 0 0
Pervasive developmental disorders R-HSA-9005895 3.497447e-02 1.456 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.497447e-02 1.456 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.702147e-02 1.432 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.398799e-02 1.469 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.398799e-02 1.469 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.734919e-02 1.428 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.624805e-02 1.441 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.624805e-02 1.441 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.437376e-02 1.464 0 0
Repression of WNT target genes R-HSA-4641265 3.497447e-02 1.456 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.903847e-02 1.409 0 0
Nuclear import of Rev protein R-HSA-180746 3.713690e-02 1.430 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.015447e-02 1.396 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.580275e-02 1.446 0 0
Co-inhibition by PD-1 R-HSA-389948 3.752769e-02 1.426 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.020408e-02 1.396 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.465140e-02 1.460 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.486122e-02 1.458 0 0
Semaphorin interactions R-HSA-373755 4.066265e-02 1.391 0 0
Deubiquitination R-HSA-5688426 4.026806e-02 1.395 0 0
Sensory processing of sound R-HSA-9659379 4.207743e-02 1.376 0 0
Interleukin-12 signaling R-HSA-9020591 3.549650e-02 1.450 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.369363e-02 1.360 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.395570e-02 1.357 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.562059e-02 1.341 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.571450e-02 1.340 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.666993e-02 1.331 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.897021e-02 1.310 0 0
Eukaryotic Translation Termination R-HSA-72764 4.897021e-02 1.310 0 0
Autophagy R-HSA-9612973 4.920459e-02 1.308 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 4.955257e-02 1.305 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.955257e-02 1.305 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.955257e-02 1.305 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.020546e-02 1.299 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.020546e-02 1.299 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.020546e-02 1.299 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.030260e-02 1.298 0 0
HDMs demethylate histones R-HSA-3214842 5.030260e-02 1.298 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.134417e-02 1.290 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.147657e-02 1.288 0 0
Vesicle-mediated transport R-HSA-5653656 5.151580e-02 1.288 0 0
Gene expression (Transcription) R-HSA-74160 5.156296e-02 1.288 0 0
Macroautophagy R-HSA-1632852 5.183608e-02 1.285 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.325483e-02 1.274 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.325483e-02 1.274 0 0
DNA Damage Reversal R-HSA-73942 5.325483e-02 1.274 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.447270e-02 1.264 0 0
Transcription of the HIV genome R-HSA-167172 5.462495e-02 1.263 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.550172e-02 1.256 0 0
Regulation of TP53 Activity R-HSA-5633007 5.672654e-02 1.246 0 0
Muscle contraction R-HSA-397014 5.693523e-02 1.245 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.970341e-02 1.224 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.970341e-02 1.224 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.975092e-02 1.224 0 0
rRNA processing R-HSA-72312 5.982037e-02 1.223 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.018584e-02 1.221 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.095270e-02 1.215 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.095498e-02 1.215 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.095498e-02 1.215 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.340679e-02 1.198 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.408128e-02 1.193 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.408128e-02 1.193 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.426179e-02 1.192 0 0
Selenocysteine synthesis R-HSA-2408557 6.433898e-02 1.192 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.463851e-02 1.072 0 0
MGMT-mediated DNA damage reversal R-HSA-5657655 8.463851e-02 1.072 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.463851e-02 1.072 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.463851e-02 1.072 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.463851e-02 1.072 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.463851e-02 1.072 0 0
MECP2 regulates transcription factors R-HSA-9022707 7.314942e-02 1.136 0 0
Regulation of PTEN localization R-HSA-8948747 7.314942e-02 1.136 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.314942e-02 1.136 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 7.314942e-02 1.136 0 0
Disinhibition of SNARE formation R-HSA-114516 7.314942e-02 1.136 0 0
Formation of annular gap junctions R-HSA-196025 8.604625e-02 1.065 0 0
WNT mediated activation of DVL R-HSA-201688 9.956209e-02 1.002 0 0
Gap junction degradation R-HSA-190873 9.956209e-02 1.002 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.331460e-02 1.079 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.331460e-02 1.079 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 9.175325e-02 1.037 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.154221e-02 1.145 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.746519e-02 1.111 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.362540e-02 1.078 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.362540e-02 1.078 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 9.663732e-02 1.015 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.863461e-02 1.163 0 0
HIV Transcription Initiation R-HSA-167161 6.863461e-02 1.163 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.863461e-02 1.163 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.826324e-02 1.106 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.857743e-02 1.053 0 0
Viral mRNA Translation R-HSA-192823 7.007024e-02 1.154 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.574989e-02 1.067 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.544585e-02 1.020 0 0
G-protein beta:gamma signalling R-HSA-397795 9.663732e-02 1.015 0 0
Disorders of Developmental Biology R-HSA-9675151 6.751559e-02 1.171 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.331460e-02 1.079 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.604625e-02 1.065 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 9.956209e-02 1.002 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.610991e-02 1.119 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.610991e-02 1.119 0 0
PCP/CE pathway R-HSA-4086400 9.057691e-02 1.043 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.751559e-02 1.171 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.331460e-02 1.079 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.523014e-02 1.124 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.175325e-02 1.037 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.305143e-02 1.136 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 7.314942e-02 1.136 0 0
ARMS-mediated activation R-HSA-170984 9.956209e-02 1.002 0 0
Signaling by Hippo R-HSA-2028269 7.523014e-02 1.124 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.331460e-02 1.079 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.663732e-02 1.015 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.336237e-02 1.135 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.815460e-02 1.008 0 0
tRNA processing in the nucleus R-HSA-6784531 9.336045e-02 1.030 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 7.314942e-02 1.136 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.956209e-02 1.002 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.398661e-02 1.027 0 0
Signaling by VEGF R-HSA-194138 9.671028e-02 1.015 0 0
Ca2+ pathway R-HSA-4086398 7.125250e-02 1.147 0 0
MAPK family signaling cascades R-HSA-5683057 9.673475e-02 1.014 0 0
RMTs methylate histone arginines R-HSA-3214858 8.333557e-02 1.079 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.175325e-02 1.037 0 0
RNA Polymerase II Transcription R-HSA-73857 9.911625e-02 1.004 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.305143e-02 1.136 0 0
Glucose metabolism R-HSA-70326 6.955445e-02 1.158 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.314942e-02 1.136 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.604625e-02 1.065 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 8.604625e-02 1.065 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 9.956209e-02 1.002 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 9.663732e-02 1.015 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.912156e-02 1.050 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.751559e-02 1.171 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.154221e-02 1.145 0 0
Interleukin-37 signaling R-HSA-9008059 7.746519e-02 1.111 0 0
Signaling by Interleukins R-HSA-449147 9.573179e-02 1.019 0 0
Interleukin-12 family signaling R-HSA-447115 6.647165e-02 1.177 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.005297e-01 0.998 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.005297e-01 0.998 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.005297e-01 0.998 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.005297e-01 0.998 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.034778e-01 0.985 0 0
Intraflagellar transport R-HSA-5620924 1.052968e-01 0.978 0 0
G-protein activation R-HSA-202040 1.096271e-01 0.960 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 1.096271e-01 0.960 0 0
Basigin interactions R-HSA-210991 1.096271e-01 0.960 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.105332e-01 0.957 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.105332e-01 0.957 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.136194e-01 0.945 0 0
Josephin domain DUBs R-HSA-5689877 1.136194e-01 0.945 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.136194e-01 0.945 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.136194e-01 0.945 0 0
Selenoamino acid metabolism R-HSA-2408522 1.141271e-01 0.943 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.177968e-01 0.929 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.177968e-01 0.929 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.177968e-01 0.929 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.190281e-01 0.924 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.190281e-01 0.924 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.220688e-01 0.913 0 0
Hedgehog 'off' state R-HSA-5610787 1.232032e-01 0.909 0 0
S Phase R-HSA-69242 1.232585e-01 0.909 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.242358e-01 0.906 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.242358e-01 0.906 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 1.242358e-01 0.906 0 0
IKBKB deficiency causes SCID R-HSA-5602636 1.242358e-01 0.906 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.242358e-01 0.906 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.242358e-01 0.906 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.242358e-01 0.906 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.242358e-01 0.906 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.242358e-01 0.906 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.242358e-01 0.906 0 0
mRNA Splicing R-HSA-72172 1.271173e-01 0.896 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.281463e-01 0.892 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.287153e-01 0.890 0 0
mTORC1-mediated signalling R-HSA-166208 1.287153e-01 0.890 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.293066e-01 0.888 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.298004e-01 0.887 0 0
Orc1 removal from chromatin R-HSA-68949 1.298004e-01 0.887 0 0
Neurexins and neuroligins R-HSA-6794361 1.298004e-01 0.887 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.322525e-01 0.879 0 0
Degradation of DVL R-HSA-4641258 1.329211e-01 0.876 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.329211e-01 0.876 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.352068e-01 0.869 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.362985e-01 0.866 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.362985e-01 0.866 0 0
Post NMDA receptor activation events R-HSA-438064 1.370797e-01 0.863 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 1.386709e-01 0.858 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.386709e-01 0.858 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.386709e-01 0.858 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.407671e-01 0.851 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.409755e-01 0.851 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.416319e-01 0.849 0 0
Activation of RAC1 R-HSA-428540 1.430760e-01 0.844 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.430760e-01 0.844 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.430760e-01 0.844 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.430760e-01 0.844 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.468562e-01 0.833 0 0
ER-Phagosome pathway R-HSA-1236974 1.475646e-01 0.831 0 0
Translation R-HSA-72766 1.479037e-01 0.830 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.621225e-01 0.790 0 0
Invadopodia formation R-HSA-8941237 1.983724e-01 0.703 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.330561e-01 0.633 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.330561e-01 0.633 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.330561e-01 0.633 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.662411e-01 0.575 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.583465e-01 0.800 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.739007e-01 0.760 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.896854e-01 0.722 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.488772e-01 0.827 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.217545e-01 0.654 0 0
Phosphorylation of the APC/C R-HSA-176412 2.217545e-01 0.654 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.217545e-01 0.654 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 1.593163e-01 0.798 0 0
G protein gated Potassium channels R-HSA-1296059 1.593163e-01 0.798 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 1.593163e-01 0.798 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.593163e-01 0.798 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.699707e-01 0.770 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.542063e-01 0.595 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.542063e-01 0.595 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.542063e-01 0.595 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.704820e-01 0.568 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.030516e-01 0.692 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.143945e-01 0.669 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.184808e-01 0.661 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.965842e-01 0.528 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.561240e-01 0.592 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.851497e-01 0.545 0 0
PTEN Regulation R-HSA-6807070 1.582647e-01 0.801 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.851497e-01 0.545 0 0
Nucleotide Excision Repair R-HSA-5696398 2.630988e-01 0.580 0 0
Activation of the pre-replicative complex R-HSA-68962 2.143945e-01 0.669 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.854999e-01 0.732 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.093132e-01 0.679 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.277540e-01 0.643 0 0
Signal regulatory protein family interactions R-HSA-391160 1.896854e-01 0.722 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.569890e-01 0.804 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.374556e-01 0.624 0 0
RNA Polymerase III Transcription R-HSA-74158 2.965842e-01 0.528 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.330561e-01 0.633 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.583465e-01 0.800 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.056517e-01 0.687 0 0
Thromboxane signalling through TP receptor R-HSA-428930 1.488772e-01 0.827 0 0
Trafficking of AMPA receptors R-HSA-399719 2.258678e-01 0.646 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.657370e-01 0.576 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.217545e-01 0.654 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.808229e-01 0.743 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.609129e-01 0.584 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.662411e-01 0.575 0 0
Killing mechanisms R-HSA-9664420 2.217545e-01 0.654 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.217545e-01 0.654 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 1.699707e-01 0.770 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.704820e-01 0.568 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.825265e-01 0.739 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.491423e-01 0.604 0 0
RAF activation R-HSA-5673000 2.727528e-01 0.564 0 0
Signal amplification R-HSA-392518 2.727528e-01 0.564 0 0
Inhibition of nitric oxide production R-HSA-9636249 1.983724e-01 0.703 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 2.662411e-01 0.575 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.896854e-01 0.722 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.143945e-01 0.669 0 0
Rap1 signalling R-HSA-392517 2.867469e-01 0.543 0 0
Frs2-mediated activation R-HSA-170968 1.739007e-01 0.760 0 0
Prolonged ERK activation events R-HSA-169893 2.217545e-01 0.654 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.621225e-01 0.790 0 0
Signalling to ERK5 R-HSA-198765 1.621225e-01 0.790 0 0
MET interacts with TNS proteins R-HSA-8875513 1.983724e-01 0.703 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.330561e-01 0.633 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.704820e-01 0.568 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.704820e-01 0.568 0 0
Diseases of Immune System R-HSA-5260271 1.569890e-01 0.804 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 1.569890e-01 0.804 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.093132e-01 0.679 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.528464e-01 0.816 0 0
GPER1 signaling R-HSA-9634597 2.371244e-01 0.625 0 0
Polo-like kinase mediated events R-HSA-156711 2.704820e-01 0.568 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.488772e-01 0.827 0 0
Inwardly rectifying K+ channels R-HSA-1296065 2.374556e-01 0.624 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.137422e-01 0.670 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.277540e-01 0.643 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.986726e-01 0.702 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.399261e-01 0.620 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 2.143945e-01 0.669 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.870475e-01 0.728 0 0
Diseases of cellular response to stress R-HSA-9675132 1.621225e-01 0.790 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.621225e-01 0.790 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.056517e-01 0.687 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.542063e-01 0.595 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.491423e-01 0.604 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.727528e-01 0.564 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.688386e-01 0.773 0 0
Regulation of insulin secretion R-HSA-422356 2.113599e-01 0.675 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.379521e-01 0.624 0 0
Adaptive Immune System R-HSA-1280218 2.090023e-01 0.680 0 0
The NLRP3 inflammasome R-HSA-844456 2.867469e-01 0.543 0 0
Platelet degranulation R-HSA-114608 2.947220e-01 0.531 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.056517e-01 0.687 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.808229e-01 0.743 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.833637e-01 0.548 0 0
Transmission across Chemical Synapses R-HSA-112315 2.636279e-01 0.579 0 0
Signaling by Hedgehog R-HSA-5358351 2.512935e-01 0.600 0 0
Interleukin-1 family signaling R-HSA-446652 2.245896e-01 0.649 0 0
Protein methylation R-HSA-8876725 2.056517e-01 0.687 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.491423e-01 0.604 0 0
Generic Transcription Pathway R-HSA-212436 2.240946e-01 0.650 0 0
EPH-Ephrin signaling R-HSA-2682334 1.696188e-01 0.771 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.322013e-01 0.634 0 0
Integration of energy metabolism R-HSA-163685 2.400756e-01 0.620 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 1.621225e-01 0.790 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.662411e-01 0.575 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.739007e-01 0.760 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.699707e-01 0.770 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.534974e-01 0.814 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.859101e-01 0.731 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.800554e-01 0.553 0 0
GAB1 signalosome R-HSA-180292 2.704820e-01 0.568 0 0
PERK regulates gene expression R-HSA-381042 2.846477e-01 0.546 0 0
Gluconeogenesis R-HSA-70263 2.371244e-01 0.625 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.056517e-01 0.687 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 1.918555e-01 0.717 0 0
Miscellaneous transport and binding events R-HSA-5223345 2.609129e-01 0.584 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 2.609129e-01 0.584 0 0
Infectious disease R-HSA-5663205 1.708963e-01 0.767 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.609129e-01 0.584 0 0
Diseases of DNA repair R-HSA-9675135 2.184808e-01 0.661 0 0
Immune System R-HSA-168256 2.422538e-01 0.616 1 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.808229e-01 0.743 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.566237e-01 0.805 0 0
DNA strand elongation R-HSA-69190 2.374556e-01 0.624 0 0
Glucagon-type ligand receptors R-HSA-420092 2.030516e-01 0.692 0 0
Nephron development R-HSA-9831926 2.704820e-01 0.568 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 1.583465e-01 0.800 0 0
TCR signaling R-HSA-202403 2.970789e-01 0.527 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.979922e-01 0.526 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.979922e-01 0.526 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.979922e-01 0.526 0 0
Phosphorylation of Emi1 R-HSA-176417 2.979922e-01 0.526 0 0
Synthesis of PS R-HSA-1483101 2.979922e-01 0.526 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.979922e-01 0.526 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.979922e-01 0.526 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 2.979922e-01 0.526 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.979922e-01 0.526 0 0
Signaling by NOTCH4 R-HSA-9013694 2.982912e-01 0.525 0 0
Hemostasis R-HSA-109582 3.018391e-01 0.520 0 0
Signal transduction by L1 R-HSA-445144 3.029716e-01 0.519 0 0
Protein hydroxylation R-HSA-9629569 3.029716e-01 0.519 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.036959e-01 0.518 0 0
G alpha (z) signalling events R-HSA-418597 3.047596e-01 0.516 0 0
Signaling by NOTCH3 R-HSA-9012852 3.047596e-01 0.516 0 0
Inositol phosphate metabolism R-HSA-1483249 3.109338e-01 0.507 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.146196e-01 0.502 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.191291e-01 0.496 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.191291e-01 0.496 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.191291e-01 0.496 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.191291e-01 0.496 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.191291e-01 0.496 0 0
MET promotes cell motility R-HSA-8875878 3.205293e-01 0.494 0 0
Potential therapeutics for SARS R-HSA-9679191 3.277828e-01 0.484 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 3.283712e-01 0.484 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.283712e-01 0.484 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.283712e-01 0.484 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.283712e-01 0.484 0 0
Leukotriene receptors R-HSA-391906 3.283712e-01 0.484 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.325132e-01 0.478 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.325132e-01 0.478 0 0
Integrin cell surface interactions R-HSA-216083 3.325431e-01 0.478 0 0
G alpha (12/13) signalling events R-HSA-416482 3.325431e-01 0.478 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.351948e-01 0.475 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.351948e-01 0.475 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.380691e-01 0.471 0 0
Regulation of beta-cell development R-HSA-186712 3.443335e-01 0.463 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.444891e-01 0.463 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.444891e-01 0.463 0 0
HIV Transcription Elongation R-HSA-167169 3.444891e-01 0.463 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.444891e-01 0.463 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.445396e-01 0.463 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.498105e-01 0.456 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.511467e-01 0.455 0 0
LDL clearance R-HSA-8964038 3.511467e-01 0.455 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.511467e-01 0.455 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.511467e-01 0.455 0 0
Signaling by ERBB2 R-HSA-1227986 3.542596e-01 0.451 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.564458e-01 0.448 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.564458e-01 0.448 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.564458e-01 0.448 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.564458e-01 0.448 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 3.574374e-01 0.447 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.574374e-01 0.447 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.574374e-01 0.447 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.574374e-01 0.447 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.574374e-01 0.447 0 0
CHL1 interactions R-HSA-447041 3.574374e-01 0.447 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.574374e-01 0.447 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.641854e-01 0.439 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 3.669644e-01 0.435 0 0
Syndecan interactions R-HSA-3000170 3.669644e-01 0.435 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.683728e-01 0.434 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.683728e-01 0.434 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.696131e-01 0.432 0 0
HCMV Late Events R-HSA-9610379 3.706897e-01 0.431 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.741045e-01 0.427 0 0
Interleukin-1 signaling R-HSA-9020702 3.756087e-01 0.425 0 0
Cellular response to starvation R-HSA-9711097 3.768713e-01 0.424 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 3.802599e-01 0.420 0 0
Activation of GABAB receptors R-HSA-991365 3.802599e-01 0.420 0 0
GABA B receptor activation R-HSA-977444 3.802599e-01 0.420 0 0
MTOR signalling R-HSA-165159 3.802599e-01 0.420 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 3.826297e-01 0.417 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.826297e-01 0.417 0 0
Neurodegenerative Diseases R-HSA-8863678 3.826297e-01 0.417 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.844465e-01 0.415 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.852473e-01 0.414 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 3.852473e-01 0.414 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.852473e-01 0.414 0 0
Adrenoceptors R-HSA-390696 3.852473e-01 0.414 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.852473e-01 0.414 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.852473e-01 0.414 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.859560e-01 0.413 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.920976e-01 0.407 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.991927e-01 0.399 0 0
Cellular response to hypoxia R-HSA-1234174 4.037607e-01 0.394 0 0
Proteasome assembly R-HSA-9907900 4.038769e-01 0.394 0 0
G1 Phase R-HSA-69236 4.038769e-01 0.394 0 0
Cyclin D associated events in G1 R-HSA-69231 4.038769e-01 0.394 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.038769e-01 0.394 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.103773e-01 0.387 0 0
ALK mutants bind TKIs R-HSA-9700645 4.118552e-01 0.385 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.118552e-01 0.385 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.118552e-01 0.385 0 0
Interleukin-1 processing R-HSA-448706 4.118552e-01 0.385 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.118552e-01 0.385 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.118552e-01 0.385 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.118552e-01 0.385 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.134392e-01 0.384 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.134392e-01 0.384 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.134392e-01 0.384 0 0
Myogenesis R-HSA-525793 4.134392e-01 0.384 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.155892e-01 0.381 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.155892e-01 0.381 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.155892e-01 0.381 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.155892e-01 0.381 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.155892e-01 0.381 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.155892e-01 0.381 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.155892e-01 0.381 0 0
Pyruvate metabolism R-HSA-70268 4.189905e-01 0.378 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.222686e-01 0.374 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.233900e-01 0.373 0 0
G1/S Transition R-HSA-69206 4.243419e-01 0.372 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.268765e-01 0.370 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.272263e-01 0.369 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.272263e-01 0.369 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.285556e-01 0.368 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.285556e-01 0.368 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.285556e-01 0.368 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.285556e-01 0.368 0 0
Synthesis of DNA R-HSA-69239 4.300134e-01 0.367 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.373131e-01 0.359 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.373131e-01 0.359 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.373131e-01 0.359 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.373131e-01 0.359 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.373131e-01 0.359 0 0
Formation of apoptosome R-HSA-111458 4.373131e-01 0.359 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.387807e-01 0.358 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.387807e-01 0.358 0 0
HIV elongation arrest and recovery R-HSA-167287 4.434638e-01 0.353 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.434638e-01 0.353 0 0
Inflammasomes R-HSA-622312 4.434638e-01 0.353 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.434638e-01 0.353 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.520340e-01 0.345 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.525161e-01 0.344 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.581534e-01 0.339 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.616129e-01 0.336 0 0
IRE1alpha activates chaperones R-HSA-381070 4.616627e-01 0.336 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.616704e-01 0.336 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.616704e-01 0.336 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.616704e-01 0.336 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.616704e-01 0.336 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.616704e-01 0.336 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.616704e-01 0.336 0 0
Signaling by APC mutants R-HSA-4839744 4.616704e-01 0.336 0 0
vRNP Assembly R-HSA-192905 4.616704e-01 0.336 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 4.616704e-01 0.336 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.616704e-01 0.336 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.616704e-01 0.336 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.616704e-01 0.336 0 0
Interleukin-2 signaling R-HSA-9020558 4.616704e-01 0.336 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.621208e-01 0.335 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.621208e-01 0.335 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.716661e-01 0.326 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.726155e-01 0.325 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.726155e-01 0.325 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.726155e-01 0.325 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.726155e-01 0.325 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.840338e-01 0.315 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.840338e-01 0.315 0 0
SARS-CoV Infections R-HSA-9679506 4.849179e-01 0.314 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.849749e-01 0.314 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.849749e-01 0.314 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.849749e-01 0.314 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.849749e-01 0.314 0 0
NF-kB is activated and signals survival R-HSA-209560 4.849749e-01 0.314 0 0
Signaling by AXIN mutants R-HSA-4839735 4.849749e-01 0.314 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.849749e-01 0.314 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 4.849749e-01 0.314 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.849749e-01 0.314 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.849749e-01 0.314 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.868422e-01 0.313 0 0
Downstream signal transduction R-HSA-186763 4.868422e-01 0.313 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.950757e-01 0.305 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.950757e-01 0.305 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.950757e-01 0.305 0 0
Neuronal System R-HSA-112316 4.968497e-01 0.304 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.999046e-01 0.301 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.008269e-01 0.300 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.059983e-01 0.296 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.072718e-01 0.295 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.072718e-01 0.295 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.072718e-01 0.295 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.072718e-01 0.295 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.072718e-01 0.295 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.072718e-01 0.295 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.072718e-01 0.295 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.072718e-01 0.295 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.072718e-01 0.295 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.072718e-01 0.295 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.072718e-01 0.295 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.072718e-01 0.295 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.072718e-01 0.295 0 0
OAS antiviral response R-HSA-8983711 5.072718e-01 0.295 0 0
Potassium Channels R-HSA-1296071 5.115672e-01 0.291 0 0
Integrin signaling R-HSA-354192 5.145638e-01 0.289 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.145638e-01 0.289 0 0
Nuclear RNA decay R-HSA-9930044 5.145638e-01 0.289 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.145638e-01 0.289 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.145638e-01 0.289 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.145638e-01 0.289 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.167970e-01 0.287 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.197053e-01 0.284 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.274676e-01 0.278 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.277854e-01 0.278 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.277854e-01 0.278 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.277854e-01 0.278 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.280481e-01 0.277 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.280481e-01 0.277 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.286047e-01 0.277 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.286047e-01 0.277 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.286047e-01 0.277 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.286047e-01 0.277 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.286047e-01 0.277 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.286047e-01 0.277 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.286047e-01 0.277 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.286047e-01 0.277 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.355614e-01 0.271 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.355614e-01 0.271 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 5.412761e-01 0.267 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 5.412761e-01 0.267 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.412761e-01 0.267 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.412761e-01 0.267 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.490152e-01 0.260 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.490152e-01 0.260 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.490152e-01 0.260 0 0
cGMP effects R-HSA-418457 5.490152e-01 0.260 0 0
Regulation of KIT signaling R-HSA-1433559 5.490152e-01 0.260 0 0
Zinc transporters R-HSA-435354 5.490152e-01 0.260 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.499991e-01 0.260 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.516543e-01 0.258 0 0
Signalling to ERKs R-HSA-187687 5.542446e-01 0.256 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.542446e-01 0.256 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.542446e-01 0.256 0 0
Oncogene Induced Senescence R-HSA-2559585 5.542446e-01 0.256 0 0
Regulation of Apoptosis R-HSA-169911 5.542446e-01 0.256 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.542446e-01 0.256 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.571416e-01 0.254 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.571416e-01 0.254 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.586729e-01 0.253 0 0
Dual incision in TC-NER R-HSA-6782135 5.586729e-01 0.253 0 0
Disease R-HSA-1643685 5.618277e-01 0.250 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.669514e-01 0.246 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.669514e-01 0.246 0 0
Glycosphingolipid transport R-HSA-9845576 5.669514e-01 0.246 0 0
RET signaling R-HSA-8853659 5.669514e-01 0.246 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.685432e-01 0.245 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.685432e-01 0.245 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.685432e-01 0.245 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.685432e-01 0.245 0 0
Protein lipoylation R-HSA-9857492 5.685432e-01 0.245 0 0
DCC mediated attractive signaling R-HSA-418885 5.685432e-01 0.245 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.685432e-01 0.245 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.685432e-01 0.245 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.685432e-01 0.245 0 0
p75NTR signals via NF-kB R-HSA-193639 5.685432e-01 0.245 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.685432e-01 0.245 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.685432e-01 0.245 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.685432e-01 0.245 0 0
Other semaphorin interactions R-HSA-416700 5.685432e-01 0.245 0 0
Amino acid transport across the plasma membrane R-HSA-352230 5.687952e-01 0.245 0 0
Leishmania infection R-HSA-9658195 5.717337e-01 0.243 0 0
Parasitic Infection Pathways R-HSA-9824443 5.717337e-01 0.243 0 0
GABA receptor activation R-HSA-977443 5.787732e-01 0.237 0 0
tRNA Aminoacylation R-HSA-379724 5.787732e-01 0.237 0 0
Degradation of AXIN R-HSA-4641257 5.793946e-01 0.237 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.793946e-01 0.237 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.793946e-01 0.237 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.872268e-01 0.231 0 0
Activation of SMO R-HSA-5635838 5.872268e-01 0.231 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.872268e-01 0.231 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.872268e-01 0.231 0 0
Attachment and Entry R-HSA-9678110 5.872268e-01 0.231 0 0
Negative regulation of FLT3 R-HSA-9706369 5.872268e-01 0.231 0 0
Extracellular matrix organization R-HSA-1474244 5.881647e-01 0.231 0 0
Aquaporin-mediated transport R-HSA-445717 5.886045e-01 0.230 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.900773e-01 0.229 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.915735e-01 0.228 0 0
tRNA processing R-HSA-72306 5.966904e-01 0.224 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.970788e-01 0.224 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.970788e-01 0.224 0 0
Developmental Cell Lineages R-HSA-9734767 5.971035e-01 0.224 0 0
Platelet homeostasis R-HSA-418346 5.975422e-01 0.224 0 0
Mitochondrial protein import R-HSA-1268020 5.982872e-01 0.223 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.982872e-01 0.223 0 0
G alpha (s) signalling events R-HSA-418555 6.025647e-01 0.220 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.034874e-01 0.219 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.034874e-01 0.219 0 0
Signaling by ALK R-HSA-201556 6.034874e-01 0.219 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 6.034874e-01 0.219 0 0
Stabilization of p53 R-HSA-69541 6.034874e-01 0.219 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.034874e-01 0.219 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.051023e-01 0.218 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.051023e-01 0.218 0 0
Glycine degradation R-HSA-6783984 6.051023e-01 0.218 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.051023e-01 0.218 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.051023e-01 0.218 0 0
Fibronectin matrix formation R-HSA-1566977 6.051023e-01 0.218 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.051023e-01 0.218 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.051023e-01 0.218 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.051023e-01 0.218 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.051023e-01 0.218 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.053394e-01 0.218 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.078196e-01 0.216 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.122407e-01 0.213 0 0
Stimuli-sensing channels R-HSA-2672351 6.122407e-01 0.213 0 0
Generation of second messenger molecules R-HSA-202433 6.151366e-01 0.211 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.151366e-01 0.211 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.172002e-01 0.210 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.191296e-01 0.208 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.194717e-01 0.208 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.199245e-01 0.208 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.222048e-01 0.206 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.222048e-01 0.206 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.222048e-01 0.206 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.222048e-01 0.206 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.222048e-01 0.206 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.222048e-01 0.206 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.265215e-01 0.203 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.265215e-01 0.203 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.266223e-01 0.203 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.266223e-01 0.203 0 0
Downstream TCR signaling R-HSA-202424 6.373306e-01 0.196 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 6.373306e-01 0.196 0 0
Intra-Golgi traffic R-HSA-6811438 6.376433e-01 0.195 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.376433e-01 0.195 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.376433e-01 0.195 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.376433e-01 0.195 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.376433e-01 0.195 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 6.376433e-01 0.195 0 0
Ephrin signaling R-HSA-3928664 6.385676e-01 0.195 0 0
Mismatch Repair R-HSA-5358508 6.385676e-01 0.195 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.385676e-01 0.195 0 0
Apoptotic factor-mediated response R-HSA-111471 6.385676e-01 0.195 0 0
SLC-mediated transport of amino acids R-HSA-9958863 6.444201e-01 0.191 0 0
Kidney development R-HSA-9830369 6.444201e-01 0.191 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.475818e-01 0.189 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.485033e-01 0.188 0 0
Regulated Necrosis R-HSA-5218859 6.531836e-01 0.185 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.542227e-01 0.184 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.542227e-01 0.184 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.542227e-01 0.184 0 0
Translesion Synthesis by POLH R-HSA-110320 6.542227e-01 0.184 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.542227e-01 0.184 0 0
Maturation of nucleoprotein R-HSA-9694631 6.542227e-01 0.184 0 0
Other interleukin signaling R-HSA-449836 6.542227e-01 0.184 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.591034e-01 0.181 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.591034e-01 0.181 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.677855e-01 0.175 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.677855e-01 0.175 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.692006e-01 0.174 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.692006e-01 0.174 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.692006e-01 0.174 0 0
Creatine metabolism R-HSA-71288 6.692006e-01 0.174 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 6.692006e-01 0.174 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.692006e-01 0.174 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 6.692006e-01 0.174 0 0
Netrin-1 signaling R-HSA-373752 6.694457e-01 0.174 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.694457e-01 0.174 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.702435e-01 0.174 0 0
Signaling by TGFB family members R-HSA-9006936 6.718446e-01 0.173 0 0
Hedgehog 'on' state R-HSA-5632684 6.785397e-01 0.168 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.795326e-01 0.168 0 0
Somitogenesis R-HSA-9824272 6.795326e-01 0.168 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.835305e-01 0.165 0 0
Rab regulation of trafficking R-HSA-9007101 6.872163e-01 0.163 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.893669e-01 0.162 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.893669e-01 0.162 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.893669e-01 0.162 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.893669e-01 0.162 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.893669e-01 0.162 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.930339e-01 0.159 0 0
Parasite infection R-HSA-9664407 6.930339e-01 0.159 0 0
Leishmania phagocytosis R-HSA-9664417 6.930339e-01 0.159 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.960727e-01 0.157 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.972406e-01 0.157 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.972406e-01 0.157 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.972406e-01 0.157 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.972406e-01 0.157 0 0
Attachment and Entry R-HSA-9694614 6.972406e-01 0.157 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.972406e-01 0.157 0 0
Toll-like Receptor Cascades R-HSA-168898 7.100781e-01 0.149 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.103575e-01 0.149 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.103575e-01 0.149 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.103575e-01 0.149 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.103575e-01 0.149 0 0
DNA Damage Bypass R-HSA-73893 7.173844e-01 0.144 0 0
Degradation of CDH1 R-HSA-9766229 7.173844e-01 0.144 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.173844e-01 0.144 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.173844e-01 0.144 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.173844e-01 0.144 0 0
UCH proteinases R-HSA-5689603 7.176973e-01 0.144 0 0
Signaling by NOTCH1 R-HSA-1980143 7.176973e-01 0.144 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.229068e-01 0.141 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.229068e-01 0.141 0 0
Formation of the ureteric bud R-HSA-9830674 7.229068e-01 0.141 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.250686e-01 0.140 0 0
Formation of the cornified envelope R-HSA-6809371 7.294977e-01 0.137 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.322887e-01 0.135 0 0
ABC transporter disorders R-HSA-5619084 7.322887e-01 0.135 0 0
The phototransduction cascade R-HSA-2514856 7.348589e-01 0.134 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.349132e-01 0.134 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.349132e-01 0.134 0 0
Complex III assembly R-HSA-9865881 7.349132e-01 0.134 0 0
PI Metabolism R-HSA-1483255 7.354473e-01 0.133 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.363047e-01 0.133 0 0
Signaling by MET R-HSA-6806834 7.462798e-01 0.127 0 0
TGFBR3 expression R-HSA-9839394 7.464001e-01 0.127 0 0
Long-term potentiation R-HSA-9620244 7.464001e-01 0.127 0 0
Laminin interactions R-HSA-3000157 7.464001e-01 0.127 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.464001e-01 0.127 0 0
Tight junction interactions R-HSA-420029 7.464001e-01 0.127 0 0
Hyaluronan degradation R-HSA-2160916 7.464001e-01 0.127 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.464001e-01 0.127 0 0
Opioid Signalling R-HSA-111885 7.476850e-01 0.126 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.536439e-01 0.123 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.570704e-01 0.121 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.573898e-01 0.121 0 0
Metalloprotease DUBs R-HSA-5689901 7.573898e-01 0.121 0 0
MET activates PTK2 signaling R-HSA-8874081 7.573898e-01 0.121 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.573898e-01 0.121 0 0
TRP channels R-HSA-3295583 7.573898e-01 0.121 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.573898e-01 0.121 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 7.573898e-01 0.121 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.661639e-01 0.116 0 0
Cristae formation R-HSA-8949613 7.679040e-01 0.115 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.679040e-01 0.115 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.679040e-01 0.115 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.679040e-01 0.115 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.679040e-01 0.115 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.745528e-01 0.111 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.745528e-01 0.111 0 0
Signaling by EGFR R-HSA-177929 7.745528e-01 0.111 0 0
Telomere Extension By Telomerase R-HSA-171319 7.779631e-01 0.109 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.779631e-01 0.109 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.779631e-01 0.109 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.779631e-01 0.109 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.779631e-01 0.109 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.779631e-01 0.109 0 0
Pyroptosis R-HSA-5620971 7.779631e-01 0.109 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.779631e-01 0.109 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.818397e-01 0.107 0 0
Late endosomal microautophagy R-HSA-9615710 7.875868e-01 0.104 0 0
mRNA Capping R-HSA-72086 7.875868e-01 0.104 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.875868e-01 0.104 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.875868e-01 0.104 0 0
Platelet calcium homeostasis R-HSA-418360 7.875868e-01 0.104 0 0
Extension of Telomeres R-HSA-180786 7.957955e-01 0.099 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.967940e-01 0.099 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.967940e-01 0.099 0 0
Neurotransmitter clearance R-HSA-112311 7.967940e-01 0.099 0 0
Activation of BH3-only proteins R-HSA-114452 7.967940e-01 0.099 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.024729e-01 0.096 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.024729e-01 0.096 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.024729e-01 0.096 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.024729e-01 0.096 0 0
Metabolism of polyamines R-HSA-351202 8.024729e-01 0.096 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.024729e-01 0.096 0 0
Budding and maturation of HIV virion R-HSA-162588 8.056026e-01 0.094 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.056026e-01 0.094 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.056026e-01 0.094 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.056026e-01 0.094 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.070344e-01 0.093 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.089557e-01 0.092 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.089557e-01 0.092 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.102758e-01 0.091 0 0
Neurotransmitter release cycle R-HSA-112310 8.130269e-01 0.090 0 0
Signaling by WNT in cancer R-HSA-4791275 8.140299e-01 0.089 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.140299e-01 0.089 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.140299e-01 0.089 0 0
G0 and Early G1 R-HSA-1538133 8.140299e-01 0.089 0 0
Signaling by PDGF R-HSA-186797 8.152483e-01 0.089 0 0
Signaling by PTK6 R-HSA-8848021 8.213549e-01 0.085 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.213549e-01 0.085 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.220924e-01 0.085 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.220924e-01 0.085 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.220924e-01 0.085 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.284309e-01 0.082 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.298057e-01 0.081 0 0
Dual Incision in GG-NER R-HSA-5696400 8.371852e-01 0.077 0 0
Mitophagy R-HSA-5205647 8.371852e-01 0.077 0 0
eNOS activation R-HSA-203615 8.371852e-01 0.077 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.371852e-01 0.077 0 0
Hyaluronan metabolism R-HSA-2142845 8.371852e-01 0.077 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.371852e-01 0.077 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.386018e-01 0.076 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.442450e-01 0.074 0 0
FLT3 signaling in disease R-HSA-9682385 8.509992e-01 0.070 0 0
Calmodulin induced events R-HSA-111933 8.509992e-01 0.070 0 0
CaM pathway R-HSA-111997 8.509992e-01 0.070 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.509992e-01 0.070 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.509992e-01 0.070 0 0
RUNX2 regulates bone development R-HSA-8941326 8.509992e-01 0.070 0 0
Mitochondrial translation elongation R-HSA-5389840 8.516875e-01 0.070 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.516875e-01 0.070 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.535482e-01 0.069 0 0
Signaling by NTRKs R-HSA-166520 8.571648e-01 0.067 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 8.574609e-01 0.067 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.574609e-01 0.067 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 8.592511e-01 0.066 0 0
Mitochondrial translation initiation R-HSA-5368286 8.601927e-01 0.065 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.636427e-01 0.064 0 0
Elastic fibre formation R-HSA-1566948 8.636427e-01 0.064 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.636427e-01 0.064 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.642828e-01 0.063 0 0
FOXO-mediated transcription R-HSA-9614085 8.642828e-01 0.063 0 0
ABC-family proteins mediated transport R-HSA-382556 8.682673e-01 0.061 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.695568e-01 0.061 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.695568e-01 0.061 0 0
Pentose phosphate pathway R-HSA-71336 8.695568e-01 0.061 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.752147e-01 0.058 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.752147e-01 0.058 0 0
Tryptophan catabolism R-HSA-71240 8.752147e-01 0.058 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.752147e-01 0.058 0 0
Interleukin-2 family signaling R-HSA-451927 8.752147e-01 0.058 0 0
Signaling by FGFR in disease R-HSA-1226099 8.774578e-01 0.057 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 8.796081e-01 0.056 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.806276e-01 0.055 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.806276e-01 0.055 0 0
FLT3 Signaling R-HSA-9607240 8.806276e-01 0.055 0 0
Cell surface interactions at the vascular wall R-HSA-202733 8.807334e-01 0.055 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.815273e-01 0.055 0 0
Iron uptake and transport R-HSA-917937 8.816572e-01 0.055 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.858059e-01 0.053 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.858059e-01 0.053 0 0
Adipogenesis R-HSA-9843745 8.892284e-01 0.051 0 0
Ca-dependent events R-HSA-111996 8.907600e-01 0.050 0 0
TBC/RABGAPs R-HSA-8854214 8.954994e-01 0.048 0 0
Signaling by SCF-KIT R-HSA-1433557 8.954994e-01 0.048 0 0
Signaling by FGFR4 R-HSA-5654743 8.954994e-01 0.048 0 0
Amine ligand-binding receptors R-HSA-375280 9.000334e-01 0.046 0 0
Mitochondrial translation termination R-HSA-5419276 9.027575e-01 0.044 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.043710e-01 0.044 0 0
DAG and IP3 signaling R-HSA-1489509 9.043710e-01 0.044 0 0
Signaling by FGFR3 R-HSA-5654741 9.043710e-01 0.044 0 0
Signaling by TGFBR3 R-HSA-9839373 9.085206e-01 0.042 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.085206e-01 0.042 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.087872e-01 0.042 0 0
Post-translational protein modification R-HSA-597592 9.091083e-01 0.041 0 0
Synthesis of PC R-HSA-1483191 9.124905e-01 0.040 0 0
Metabolism of proteins R-HSA-392499 9.140643e-01 0.039 0 0
NGF-stimulated transcription R-HSA-9031628 9.162882e-01 0.038 0 0
Metal ion SLC transporters R-HSA-425410 9.162882e-01 0.038 0 0
Innate Immune System R-HSA-168249 9.188012e-01 0.037 1 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.199214e-01 0.036 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.226465e-01 0.035 0 0
Interferon alpha/beta signaling R-HSA-909733 9.242370e-01 0.034 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.267222e-01 0.033 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.299031e-01 0.032 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.299031e-01 0.032 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.332631e-01 0.030 0 0
Cellular response to chemical stress R-HSA-9711123 9.396425e-01 0.027 0 0
NRAGE signals death through JNK R-HSA-193648 9.413062e-01 0.026 0 0
TNF signaling R-HSA-75893 9.413062e-01 0.026 0 0
Ion homeostasis R-HSA-5578775 9.413062e-01 0.026 0 0
Signaling by FGFR1 R-HSA-5654736 9.413062e-01 0.026 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.462929e-01 0.024 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.503242e-01 0.022 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.503314e-01 0.022 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.508565e-01 0.022 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.517896e-01 0.021 0 0
Ion channel transport R-HSA-983712 9.523372e-01 0.021 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.529910e-01 0.021 0 0
MAP kinase activation R-HSA-450294 9.529910e-01 0.021 0 0
PLC beta mediated events R-HSA-112043 9.529910e-01 0.021 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.535334e-01 0.021 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.547265e-01 0.020 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.550328e-01 0.020 0 0
Heme signaling R-HSA-9707616 9.550328e-01 0.020 0 0
Complex I biogenesis R-HSA-6799198 9.569861e-01 0.019 0 0
Cardiac conduction R-HSA-5576891 9.576051e-01 0.019 0 0
IGF1R signaling cascade R-HSA-2428924 9.588547e-01 0.018 0 0
Circadian clock R-HSA-9909396 9.589792e-01 0.018 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.606422e-01 0.017 0 0
SLC transporter disorders R-HSA-5619102 9.632475e-01 0.016 0 0
G-protein mediated events R-HSA-112040 9.639878e-01 0.016 0 0
RSV-host interactions R-HSA-9833110 9.641518e-01 0.016 0 0
Mitochondrial translation R-HSA-5368287 9.674893e-01 0.014 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.684659e-01 0.014 0 0
COPII-mediated vesicle transport R-HSA-204005 9.684814e-01 0.014 0 0
Interleukin-17 signaling R-HSA-448424 9.684814e-01 0.014 0 0
ECM proteoglycans R-HSA-3000178 9.698512e-01 0.013 0 0
Metabolism of cofactors R-HSA-8978934 9.698512e-01 0.013 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.703529e-01 0.013 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.703529e-01 0.013 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.711615e-01 0.013 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.711615e-01 0.013 0 0
Keratinization R-HSA-6805567 9.714050e-01 0.013 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.724150e-01 0.012 0 0
Signaling by ERBB4 R-HSA-1236394 9.736140e-01 0.012 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.743135e-01 0.011 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.762814e-01 0.010 0 0
Translation of Structural Proteins R-HSA-9694635 9.769078e-01 0.010 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.788722e-01 0.009 0 0
Signaling by FGFR2 R-HSA-5654738 9.797909e-01 0.009 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.798384e-01 0.009 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.803796e-01 0.009 0 0
Protein localization R-HSA-9609507 9.811063e-01 0.008 0 0
Neddylation R-HSA-8951664 9.816058e-01 0.008 0 0
Death Receptor Signaling R-HSA-73887 9.817452e-01 0.008 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.823145e-01 0.008 0 0
PPARA activates gene expression R-HSA-1989781 9.823635e-01 0.008 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.824997e-01 0.008 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.837878e-01 0.007 0 0
Interferon gamma signaling R-HSA-877300 9.846423e-01 0.007 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.855058e-01 0.006 0 0
Phospholipid metabolism R-HSA-1483257 9.858281e-01 0.006 0 0
G alpha (q) signalling events R-HSA-416476 9.863151e-01 0.006 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.883532e-01 0.005 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.885781e-01 0.005 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.891578e-01 0.005 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.896297e-01 0.005 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.900811e-01 0.004 0 0
Mitochondrial protein degradation R-HSA-9837999 9.900811e-01 0.004 0 0
Signaling by FGFR R-HSA-190236 9.920601e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.924059e-01 0.003 0 0
Visual phototransduction R-HSA-2187338 9.945295e-01 0.002 0 0
Gastrulation R-HSA-9758941 9.949432e-01 0.002 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.951383e-01 0.002 0 0
Transport of small molecules R-HSA-382551 9.951910e-01 0.002 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.955067e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.955498e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.959292e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.969201e-01 0.001 0 0
Mitochondrial biogenesis R-HSA-1592230 9.970202e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.986988e-01 0.001 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.988674e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.988882e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.998018e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998438e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999202e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999366e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999442e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999657e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999883e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999889e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999890e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999960e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999965e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999983e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999991e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999999e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways