GRK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00505 S60 Sugiyama KPNA3 QIP2 KRDEHLLKKRNVPQEEsLEDsDVDADFKAQNVTLEAILQNA
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O95394 S64 Sugiyama PGM3 AGM1 LLAVLRSKQTKSTIGVMVtAsHNPEEDNGVKLVDPLGEMLA
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P05787 S475 Sugiyama KRT8 CYK8 TSSSRAVVVKKIETRDGKLVsEssDVLPK____________
P07814 S747 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 ETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVREL
P08100 S334 GPS6|SIGNOR|ELM|iPTMNet|EPSD RHO OPN2 RNCMLTTICCGKNPLGDDEAsAtVsKtETsQVAPA______
P08100 S338 GPS6|SIGNOR|ELM|iPTMNet|EPSD RHO OPN2 LTTICCGKNPLGDDEAsAtVsKtETsQVAPA__________
P08100 S343 GPS6|SIGNOR|ELM|iPTMNet|EPSD RHO OPN2 CGKNPLGDDEAsAtVsKtETsQVAPA_______________
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S535 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
P08238 T537 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEESK
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7 S54 Sugiyama TUBA3C TUBA2 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P15531 S120 Sugiyama NME1 NDPKA NM23 KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P25705 S53 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR
P25788 S243 Sugiyama PSMA3 HC8 PSC8 GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P25788 Y239 Sugiyama PSMA3 HC8 PSC8 ELTNGRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM____
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35579 S1308 Sugiyama MYH9 LLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLs
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P41145 S358 EPSD|PSP OPRK1 OPRK KRCFRDFCFPLKMRMERQSTsRVRNTVQDPAYLRDIDGMNK
P41227 S216 Sugiyama NAA10 ARD1 ARD1A TE2 EEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDsAs_
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P49137 S272 GPS6 MAPKAPK2 IMYILLCGYPPFYSNHGLAIsPGMKTRIRMGQYEFPNPEWS
P49137 T222 GPS6 MAPKAPK2 ILKLtDFGFAKEttsHNsLttPCytPyyVAPEVLGPEKYDK
P49137 T25 GPS6 MAPKAPK2 SQGQsPPVPFPAPAPPPQPPtPALPHPPAQPPPPPPQQFPQ
P49137 T334 GPS6 MAPKAPK2 MTItEFMNHPWIMQSTKVPQtPLHtsRVLKEDKERWEDVKE
P55060 S342 Sugiyama CSE1L CAS XPO2 ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P56385 S66 Sugiyama ATP5ME ATP5I ATP5K EEKKKQDELKRIARELAEDDsILK_________________
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P61247 S263 Sugiyama RPS3A FTE1 MFTL GDEtGAKVERADGyEPPVQEsV___________________
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363 S54 Sugiyama TUBA1B GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q13435 S289 Sugiyama SF3B2 SAP145 IPQALEKILQLKESRQEEMNsQQEEEEMETDARssLGQsAs
Q13561 S391 Sugiyama DCTN2 DCTN50 LTQVQTTMRENLATVEGNFAsIDERMKKLGK__________
Q15021 T1331 Sugiyama NCAPD2 CAPD2 CNAP1 KIAA0159 QRAPsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHPN
Q15835 S21 GPS6|SIGNOR|iPTMNet|EPSD GRK1 RHOK MDFGsLETVVANSAFIAARGsFDGSSSQPSRDKKYLAKLKL
Q15835 S491 SIGNOR|iPTMNet|EPSD GRK1 RHOK PFIPDSKTVYAKDIQDVGAFstVKGVAFDKTDTEFFQEFAT
Q15835 T492 SIGNOR|iPTMNet|EPSD GRK1 RHOK FIPDSKTVYAKDIQDVGAFstVKGVAFDKTDTEFFQEFATG
Q58FF7 S408 Sugiyama HSP90AB3P HSP90BC EPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEE
Q58FF7 T410 Sugiyama HSP90AB3P HSP90BC IDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKKMEESK
Q58FF8 S308 Sugiyama HSP90AB2P HSP90BB YMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKRMEE
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2 S54 Sugiyama TUBA3E GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 S54 Sugiyama TUBA1A TUBA3 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q92973 S339 Sugiyama TNPO1 KPNB2 MIP1 TRN SDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQQHDE
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q99497 S57 Sugiyama PARK7 GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q99613 S39 Sugiyama EIF3C EIF3S8 GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99733 S125 Sugiyama NAP1L4 NAP2 KRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKVVVTE
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3 S54 Sugiyama TUBA1C TUBA6 GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H2G2 S362 Sugiyama SLK KIAA0204 STK2 DLsIAssEEDKLsQNACILEsVSEKtERSNsEDKLNSKILN
Q9H2G2 S518 Sugiyama SLK KIAA0204 STK2 tVDLVSQEtGEKEANIQAVDsEVGLTKEDtQEKLGEDDKTQ
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.000001 5.922 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.000001 5.991 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.000002 5.799 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.000002 5.640 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.000003 5.565 0 0
Chromatin organization R-HSA-4839726 0.000011 4.940 0 0
Chromatin modifying enzymes R-HSA-3247509 0.000013 4.902 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.000059 4.232 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.000075 4.123 0 0
Cell Cycle R-HSA-1640170 0.000074 4.132 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.000076 4.121 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.000121 3.917 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.000148 3.829 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.000189 3.723 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.000234 3.630 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.000352 3.453 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.000352 3.453 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.000436 3.360 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.000441 3.355 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.000545 3.263 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.000545 3.263 0 0
Cell Cycle, Mitotic R-HSA-69278 0.000647 3.189 0 0
M Phase R-HSA-68886 0.000687 3.163 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000676 3.170 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.000833 3.079 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.000833 3.079 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.000962 3.017 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.000963 3.016 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.001018 2.992 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.001143 2.942 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.001151 2.939 0 0
Nuclear import of Rev protein R-HSA-180746 0.001236 2.908 0 0
Signal Transduction R-HSA-162582 0.001297 2.887 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.001889 2.724 0 0
MTOR signalling R-HSA-165159 0.001914 2.718 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.002087 2.680 0 0
HIV Life Cycle R-HSA-162587 0.002218 2.654 0 0
HATs acetylate histones R-HSA-3214847 0.002241 2.650 0 0
Mitotic Anaphase R-HSA-68882 0.002370 2.625 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.002532 2.597 0 0
Mitotic Prometaphase R-HSA-68877 0.002738 2.563 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.003049 2.516 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.003049 2.516 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.003048 2.516 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.002933 2.533 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.003396 2.469 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.003530 2.452 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.004071 2.390 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.004104 2.387 0 0
Ephrin signaling R-HSA-3928664 0.004704 2.328 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.004675 2.330 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.004824 2.317 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.004824 2.317 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.005033 2.298 0 0
Signaling by EGFR R-HSA-177929 0.005138 2.289 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.005256 2.279 0 0
Signaling by ALK in cancer R-HSA-9700206 0.005256 2.279 0 0
mRNA Splicing R-HSA-72172 0.006000 2.222 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.005895 2.230 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.006338 2.198 0 0
Long-term potentiation R-HSA-9620244 0.006820 2.166 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.007249 2.140 0 0
mRNA 3'-end processing R-HSA-72187 0.007849 2.105 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.008504 2.070 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.008488 2.071 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.008504 2.070 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.008648 2.063 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.008666 2.062 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.009258 2.033 0 0
Mitotic Prophase R-HSA-68875 0.009092 2.041 0 0
Apoptotic execution phase R-HSA-75153 0.009372 2.028 0 0
Cellular response to heat stress R-HSA-3371556 0.009813 2.008 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.010132 1.994 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.010132 1.994 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.010761 1.968 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.009905 2.004 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.010914 1.962 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.010761 1.968 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.010530 1.978 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.011125 1.954 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.010761 1.968 0 0
Cell-Cell communication R-HSA-1500931 0.010547 1.977 0 0
tRNA processing in the nucleus R-HSA-6784531 0.010329 1.986 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.012385 1.907 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.012505 1.903 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.012708 1.896 0 0
mTORC1-mediated signalling R-HSA-166208 0.012898 1.889 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 0.013685 1.864 0 0
Regulation of CDH1 Function R-HSA-9764561 0.013946 1.856 0 0
Signaling by Hippo R-HSA-2028269 0.014070 1.852 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.016423 1.785 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.016588 1.780 0 0
Cell junction organization R-HSA-446728 0.016231 1.790 0 0
Regulation of TP53 Activity R-HSA-5633007 0.016670 1.778 0 0
Inositol phosphate metabolism R-HSA-1483249 0.015552 1.808 0 0
Interleukin-37 signaling R-HSA-9008059 0.015543 1.808 0 0
Formation of annular gap junctions R-HSA-196025 0.016851 1.773 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.016851 1.773 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.016851 1.773 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.016923 1.772 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.017098 1.767 0 0
snRNP Assembly R-HSA-191859 0.017203 1.764 0 0
Metabolism of non-coding RNA R-HSA-194441 0.017203 1.764 0 0
Nucleotide Excision Repair R-HSA-5696398 0.017526 1.756 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.019031 1.721 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.017969 1.745 0 0
DNA Repair R-HSA-73894 0.020135 1.696 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.020545 1.687 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.021000 1.678 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.022310 1.652 0 0
Gap junction degradation R-HSA-190873 0.022310 1.652 0 0
Signaling by RAS mutants R-HSA-6802949 0.022997 1.638 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.022997 1.638 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.022997 1.638 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.022997 1.638 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.021332 1.671 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.022200 1.654 0 0
Metabolism of RNA R-HSA-8953854 0.021856 1.660 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.023614 1.627 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.023614 1.627 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.024470 1.611 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.024819 1.605 0 0
DCC mediated attractive signaling R-HSA-418885 0.027421 1.562 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.027421 1.562 0 0
RAF activation R-HSA-5673000 0.030399 1.517 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.030453 1.516 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.027912 1.554 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.028049 1.552 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.028454 1.546 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.031874 1.497 0 0
HIV Infection R-HSA-162906 0.033081 1.480 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.033983 1.469 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.034283 1.465 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.034283 1.465 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.034897 1.457 0 0
Ca-dependent events R-HSA-111996 0.034897 1.457 0 0
Separation of Sister Chromatids R-HSA-2467813 0.034962 1.456 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.039369 1.405 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.039369 1.405 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.039369 1.405 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.036935 1.433 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.036144 1.442 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.036144 1.442 0 0
Calmodulin induced events R-HSA-111933 0.038413 1.416 0 0
CaM pathway R-HSA-111997 0.038413 1.416 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.038954 1.409 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.042117 1.376 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.042905 1.367 0 0
Signaling by VEGF R-HSA-194138 0.044238 1.354 0 0
PLC beta mediated events R-HSA-112043 0.044372 1.353 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.044556 1.351 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.044556 1.351 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.044793 1.349 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.045042 1.346 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.045830 1.339 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.045830 1.339 0 0
Homology Directed Repair R-HSA-5693538 0.047367 1.325 0 0
Trafficking of AMPA receptors R-HSA-399719 0.047168 1.326 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.046363 1.334 0 0
Adherens junctions interactions R-HSA-418990 0.051696 1.287 0 0
Deubiquitination R-HSA-5688426 0.047661 1.322 0 0
DAG and IP3 signaling R-HSA-1489509 0.047193 1.326 0 0
Post NMDA receptor activation events R-HSA-438064 0.047717 1.321 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.052258 1.282 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.052258 1.282 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 0.059044 1.229 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.059044 1.229 0 0
SOS-mediated signalling R-HSA-112412 0.059044 1.229 0 0
Pervasive developmental disorders R-HSA-9005895 0.053971 1.268 0 0
Disorders of Nervous System Development R-HSA-9697154 0.053971 1.268 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.053971 1.268 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.054048 1.267 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.052896 1.277 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.058326 1.234 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.058118 1.236 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.054048 1.267 0 0
TGFBR3 expression R-HSA-9839394 0.058030 1.236 0 0
Repression of WNT target genes R-HSA-4641265 0.053971 1.268 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.059044 1.229 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.059044 1.229 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.053971 1.268 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.059044 1.229 0 0
Cell-cell junction organization R-HSA-421270 0.059730 1.224 0 0
Cell Cycle Checkpoints R-HSA-69620 0.053570 1.271 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.053571 1.271 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.059050 1.229 0 0
Membrane Trafficking R-HSA-199991 0.060376 1.219 0 0
FLT3 Signaling R-HSA-9607240 0.064269 1.192 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.064376 1.191 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.064376 1.191 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.064401 1.191 0 0
Signaling by NTRKs R-HSA-166520 0.064751 1.189 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.065438 1.184 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.065438 1.184 0 0
Striated Muscle Contraction R-HSA-390522 0.065622 1.183 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.065764 1.182 0 0
Host Interactions of HIV factors R-HSA-162909 0.066062 1.180 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.066519 1.177 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 0.083954 1.076 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 0.083954 1.076 0 0
FLT3 mutants bind TKIs R-HSA-9702509 0.083954 1.076 0 0
PDGFR mutants bind TKIs R-HSA-9674428 0.083954 1.076 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 0.083954 1.076 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 0.083954 1.076 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 0.083954 1.076 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 0.083954 1.076 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 0.083954 1.076 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 0.083954 1.076 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 0.083954 1.076 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 0.083954 1.076 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 0.083954 1.076 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 0.083954 1.076 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 0.083954 1.076 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 0.083954 1.076 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 0.083954 1.076 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 0.083954 1.076 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 0.083954 1.076 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 0.083954 1.076 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 0.083954 1.076 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 0.083954 1.076 0 0
MET interacts with TNS proteins R-HSA-8875513 0.072118 1.142 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.072118 1.142 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 0.098196 1.008 0 0
Regulation of gap junction activity R-HSA-191650 0.098196 1.008 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.098196 1.008 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.098196 1.008 0 0
Type I hemidesmosome assembly R-HSA-446107 0.073833 1.132 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.073833 1.132 0 0
MET receptor recycling R-HSA-8875656 0.073833 1.132 0 0
ARMS-mediated activation R-HSA-170984 0.090086 1.045 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.090086 1.045 0 0
ALK mutants bind TKIs R-HSA-9700645 0.090086 1.045 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.075749 1.121 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.071498 1.146 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.081250 1.090 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.091670 1.038 0 0
MAP2K and MAPK activation R-HSA-5674135 0.070482 1.152 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.086094 1.065 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.092858 1.032 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.092858 1.032 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.075163 1.124 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.091245 1.040 0 0
FLT3 signaling in disease R-HSA-9682385 0.087880 1.056 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.098196 1.008 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.073833 1.132 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.092858 1.032 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.096332 1.016 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.087142 1.060 0 0
Regulation of KIT signaling R-HSA-1433559 0.075749 1.121 0 0
Heme signaling R-HSA-9707616 0.093292 1.030 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.086673 1.062 0 0
G-protein mediated events R-HSA-112040 0.070725 1.150 0 0
Gene expression (Transcription) R-HSA-74160 0.085862 1.066 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.090086 1.045 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.091962 1.036 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.081250 1.090 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.093292 1.030 0 0
Signaling by ERBB2 R-HSA-1227986 0.080940 1.092 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.090086 1.045 0 0
TBC/RABGAPs R-HSA-8854214 0.083970 1.076 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.085054 1.070 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 0.098196 1.008 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.099047 1.004 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.100301 0.999 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.100301 0.999 0 0
Negative regulation of FLT3 R-HSA-9706369 0.101266 0.995 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.101266 0.995 0 0
Prolonged ERK activation events R-HSA-169893 0.101266 0.995 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.101266 0.995 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.102742 0.988 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.105417 0.977 0 0
Gene Silencing by RNA R-HSA-211000 0.107256 0.970 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.107678 0.968 0 0
2-LTR circle formation R-HSA-164843 0.107678 0.968 0 0
Regulation of CDH11 function R-HSA-9762292 0.107678 0.968 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.107678 0.968 0 0
Signaling by Leptin R-HSA-2586552 0.107678 0.968 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.107678 0.968 0 0
Signaling by TGFB family members R-HSA-9006936 0.109764 0.960 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.112020 0.951 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.114954 0.939 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.115161 0.939 0 0
Disorders of Developmental Biology R-HSA-9675151 0.115326 0.938 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.126438 0.898 0 0
IRS activation R-HSA-74713 0.126438 0.898 0 0
G2 Phase R-HSA-68911 0.126438 0.898 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 0.126438 0.898 0 0
GAB1 signalosome R-HSA-180292 0.145787 0.836 0 0
PKA activation R-HSA-163615 0.145787 0.836 0 0
PKA activation in glucagon signalling R-HSA-164378 0.145787 0.836 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.126751 0.897 0 0
Deadenylation of mRNA R-HSA-429947 0.126751 0.897 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.139635 0.855 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.139635 0.855 0 0
Centrosome maturation R-HSA-380287 0.118856 0.925 0 0
EPH-Ephrin signaling R-HSA-2682334 0.119491 0.923 0 0
DNA Double Strand Break Response R-HSA-5693606 0.128769 0.890 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.123380 0.909 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.143123 0.844 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.131718 0.880 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.132800 0.877 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.131155 0.882 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 0.126438 0.898 0 0
Nuclear RNA decay R-HSA-9930044 0.131718 0.880 0 0
MAPK family signaling cascades R-HSA-5683057 0.131121 0.882 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.143495 0.843 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.133249 0.875 0 0
Bicarbonate transporters R-HSA-425381 0.126478 0.898 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.145787 0.836 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.126751 0.897 0 0
HDMs demethylate histones R-HSA-3214842 0.139635 0.855 0 0
Rab regulation of trafficking R-HSA-9007101 0.119974 0.921 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 0.126478 0.898 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.118856 0.925 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.128182 0.892 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.143495 0.843 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.130777 0.883 0 0
NrCAM interactions R-HSA-447038 0.126438 0.898 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.126438 0.898 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.146347 0.835 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.146347 0.835 0 0
Integration of provirus R-HSA-162592 0.146347 0.835 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.146347 0.835 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.160864 0.794 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.160864 0.794 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 0.160864 0.794 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.160864 0.794 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.160864 0.794 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 0.160864 0.794 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 0.160864 0.794 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.160864 0.794 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 0.231320 0.636 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.156295 0.806 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.156295 0.806 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.295865 0.529 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.295865 0.529 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 0.295865 0.529 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.295865 0.529 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 0.295865 0.529 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.295865 0.529 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.295865 0.529 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.295865 0.529 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 0.295865 0.529 0 0
Signaling by RAS GAP mutants R-HSA-9753510 0.295865 0.529 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.295865 0.529 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.295865 0.529 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.295865 0.529 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.295865 0.529 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 0.295865 0.529 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.295865 0.529 0 0
STAT5 Activation R-HSA-9645135 0.187299 0.727 0 0
Autointegration results in viral DNA circles R-HSA-177539 0.187299 0.727 0 0
MECP2 regulates transcription factors R-HSA-9022707 0.219047 0.659 0 0
Disinhibition of SNARE formation R-HSA-114516 0.219047 0.659 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 0.354994 0.450 0 0
MET activates PTPN11 R-HSA-8865999 0.354994 0.450 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.167148 0.777 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.167148 0.777 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.167148 0.777 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.188743 0.724 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.188743 0.724 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.188743 0.724 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.210999 0.676 0 0
WNT mediated activation of DVL R-HSA-201688 0.283453 0.548 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.283453 0.548 0 0
Calcineurin activates NFAT R-HSA-2025928 0.283453 0.548 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 0.409161 0.388 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 0.409161 0.388 0 0
Signaling by MAP2K mutants R-HSA-9652169 0.409161 0.388 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.178981 0.747 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.233784 0.631 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.315576 0.501 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 0.315576 0.501 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.167006 0.777 0 0
HIV elongation arrest and recovery R-HSA-167287 0.181426 0.741 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.181426 0.741 0 0
Dual Incision in GG-NER R-HSA-5696400 0.154962 0.810 0 0
Notch-HLH transcription pathway R-HSA-350054 0.232790 0.633 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.347359 0.459 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.347359 0.459 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.347359 0.459 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 0.458781 0.338 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.304123 0.517 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.378634 0.422 0 0
Activation of RAC1 R-HSA-428540 0.378634 0.422 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.378634 0.422 0 0
Meiotic synapsis R-HSA-1221632 0.171876 0.765 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.327865 0.484 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.233884 0.631 0 0
Recycling pathway of L1 R-HSA-437239 0.212095 0.673 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.351592 0.454 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.351592 0.454 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.409261 0.388 0 0
Polymerase switching R-HSA-69091 0.409261 0.388 0 0
Leading Strand Synthesis R-HSA-69109 0.409261 0.388 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.409261 0.388 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.409261 0.388 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.409261 0.388 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.409261 0.388 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.409261 0.388 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.409261 0.388 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 0.504238 0.297 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.504238 0.297 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 0.504238 0.297 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 0.504238 0.297 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.198278 0.703 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.375217 0.426 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.375217 0.426 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.375217 0.426 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.375217 0.426 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.375217 0.426 0 0
HSF1-dependent transactivation R-HSA-3371571 0.263363 0.579 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.250589 0.601 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.348576 0.458 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.348576 0.458 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.217647 0.662 0 0
Lagging Strand Synthesis R-HSA-69186 0.398664 0.399 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.368238 0.434 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.236745 0.626 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.468149 0.330 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.468149 0.330 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.468149 0.330 0 0
Signaling by LTK in cancer R-HSA-9842640 0.545878 0.263 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 0.545878 0.263 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.545878 0.263 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 0.545878 0.263 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 0.545878 0.263 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 0.545878 0.263 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 0.545878 0.263 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 0.545878 0.263 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.253667 0.596 0 0
FGFR2 alternative splicing R-HSA-6803529 0.444746 0.352 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.444746 0.352 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.394866 0.404 0 0
Dual incision in TC-NER R-HSA-6782135 0.359497 0.444 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.359497 0.444 0 0
Erythropoietin activates RAS R-HSA-9027284 0.496253 0.304 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.496253 0.304 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.496253 0.304 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.496253 0.304 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.496253 0.304 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.496253 0.304 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.467263 0.330 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.467263 0.330 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.428990 0.368 0 0
HIV Transcription Initiation R-HSA-167161 0.428990 0.368 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.428990 0.368 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.523391 0.281 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.523391 0.281 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 0.584024 0.234 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.584024 0.234 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 0.584024 0.234 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 0.584024 0.234 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 0.584024 0.234 0 0
Recycling of eIF2:GDP R-HSA-72731 0.584024 0.234 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 0.584024 0.234 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.584024 0.234 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.462709 0.335 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.483905 0.315 0 0
Translation initiation complex formation R-HSA-72649 0.460313 0.337 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.511004 0.292 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 0.549527 0.260 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 0.549527 0.260 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.495813 0.305 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.490359 0.309 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.520669 0.283 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.512077 0.291 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.519839 0.284 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.552772 0.257 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.552772 0.257 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.552772 0.257 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.552772 0.257 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.574636 0.241 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 0.574636 0.241 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.490988 0.309 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.572843 0.242 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.574761 0.241 0 0
Signaling by Erythropoietin R-HSA-9006335 0.592343 0.227 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.592343 0.227 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.590157 0.229 0 0
Attenuation phase R-HSA-3371568 0.590157 0.229 0 0
Transcription of the HIV genome R-HSA-167172 0.351256 0.454 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.258974 0.587 0 0
Downstream signal transduction R-HSA-186763 0.227175 0.644 0 0
HIV Transcription Elongation R-HSA-167169 0.590157 0.229 0 0
mRNA Capping R-HSA-72086 0.592343 0.227 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.375217 0.426 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.153077 0.815 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.153064 0.815 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.592343 0.227 0 0
DNA Damage Bypass R-HSA-73893 0.383701 0.416 0 0
RNA Polymerase III Transcription R-HSA-74158 0.520669 0.283 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.403503 0.394 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.590157 0.229 0 0
Signaling by PDGF R-HSA-186797 0.166895 0.778 0 0
DNA strand elongation R-HSA-69190 0.426818 0.370 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.211549 0.675 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.317621 0.498 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.526417 0.279 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.540374 0.267 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.257235 0.590 0 0
G0 and Early G1 R-HSA-1538133 0.243125 0.614 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.343439 0.464 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.309341 0.510 0 0
Integrin signaling R-HSA-354192 0.259361 0.586 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.262691 0.581 0 0
MET promotes cell motility R-HSA-8875878 0.360570 0.443 0 0
HCMV Early Events R-HSA-9609690 0.517541 0.286 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.219047 0.659 0 0
PI3K/AKT activation R-HSA-198203 0.315576 0.501 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.347359 0.459 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.378634 0.422 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.243125 0.614 0 0
Polo-like kinase mediated events R-HSA-156711 0.327865 0.484 0 0
G-protein beta:gamma signalling R-HSA-397795 0.259361 0.586 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 0.504238 0.297 0 0
p38MAPK events R-HSA-171007 0.496253 0.304 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.395447 0.403 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.573340 0.242 0 0
Myogenesis R-HSA-525793 0.153064 0.815 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.483905 0.315 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.526417 0.279 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.322322 0.492 0 0
IRS-mediated signalling R-HSA-112399 0.345466 0.462 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.322086 0.492 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.292428 0.534 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.167148 0.777 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.409161 0.388 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 0.458781 0.338 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.409261 0.388 0 0
VLDLR internalisation and degradation R-HSA-8866427 0.409261 0.388 0 0
Signaling by MST1 R-HSA-8852405 0.504238 0.297 0 0
Formation of axial mesoderm R-HSA-9796292 0.439129 0.357 0 0
DARPP-32 events R-HSA-180024 0.368238 0.434 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.584024 0.234 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.552772 0.257 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.552772 0.257 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.148643 0.828 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.309341 0.510 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.179551 0.746 0 0
Signal transduction by L1 R-HSA-445144 0.178981 0.747 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.444746 0.352 0 0
Generation of second messenger molecules R-HSA-202433 0.233884 0.631 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.405383 0.392 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.381607 0.418 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.156295 0.806 0 0
Formation of the posterior neural plate R-HSA-9832991 0.347359 0.459 0 0
Synthesis of PI R-HSA-1483226 0.347359 0.459 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 0.458781 0.338 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.458781 0.338 0 0
Activation of AKT2 R-HSA-165158 0.458781 0.338 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.327865 0.484 0 0
Adipogenesis R-HSA-9843745 0.155684 0.808 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.387863 0.411 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.387863 0.411 0 0
PI3K Cascade R-HSA-109704 0.399111 0.399 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.465104 0.332 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.511004 0.292 0 0
Tight junction interactions R-HSA-420029 0.511004 0.292 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.482253 0.317 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.546106 0.263 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.185233 0.732 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.427855 0.369 0 0
L1CAM interactions R-HSA-373760 0.256288 0.591 0 0
IGF1R signaling cascade R-HSA-2428924 0.299948 0.523 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.192878 0.715 0 0
RNA Polymerase I Transcription R-HSA-73864 0.343495 0.464 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.413262 0.384 0 0
Oncogene Induced Senescence R-HSA-2559585 0.167216 0.777 0 0
Neurexins and neuroligins R-HSA-6794361 0.161656 0.791 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.387863 0.411 0 0
Circadian clock R-HSA-9909396 0.424465 0.372 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.289876 0.538 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.338302 0.471 0 0
PTEN Regulation R-HSA-6807070 0.298661 0.525 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.429843 0.367 0 0
Meiosis R-HSA-1500620 0.429106 0.367 0 0
Signaling by SCF-KIT R-HSA-1433557 0.165066 0.782 0 0
Formation of definitive endoderm R-HSA-9823730 0.375217 0.426 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.210999 0.676 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.256977 0.590 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.280460 0.552 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.347359 0.459 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.327865 0.484 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.309341 0.510 0 0
HDACs deacetylate histones R-HSA-3214815 0.317621 0.498 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.319438 0.496 0 0
GPER1 signaling R-HSA-9634597 0.368292 0.434 0 0
Syndecan interactions R-HSA-3000170 0.467263 0.330 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 0.584024 0.234 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.574636 0.241 0 0
Protein ubiquitination R-HSA-8852135 0.307540 0.512 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.489363 0.310 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.312632 0.505 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.251195 0.600 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 0.196446 0.707 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.280460 0.552 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.248119 0.605 0 0
Rap1 signalling R-HSA-392517 0.351592 0.454 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.387680 0.412 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.387680 0.412 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.387680 0.412 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.387680 0.412 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.179863 0.745 0 0
Cellular Senescence R-HSA-2559583 0.163641 0.786 0 0
Signalling to ERKs R-HSA-187687 0.167216 0.777 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.328926 0.483 0 0
Insulin receptor signalling cascade R-HSA-74751 0.444008 0.353 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.210999 0.676 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.283453 0.548 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 0.549527 0.260 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.410693 0.386 0 0
Signaling by MET R-HSA-6806834 0.156413 0.806 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.472795 0.325 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.270588 0.568 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.351592 0.454 0 0
Signaling by WNT R-HSA-195721 0.368178 0.434 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.289876 0.538 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.407404 0.390 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.428990 0.368 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.565859 0.247 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.592343 0.227 0 0
Axon guidance R-HSA-422475 0.282778 0.549 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.259361 0.586 0 0
Cilium Assembly R-HSA-5617833 0.468462 0.329 0 0
Ca2+ pathway R-HSA-4086398 0.416597 0.380 0 0
ESR-mediated signaling R-HSA-8939211 0.257719 0.589 0 0
Opioid Signalling R-HSA-111885 0.312420 0.505 0 0
Nervous system development R-HSA-9675108 0.254322 0.595 0 0
Inhibition of PKR R-HSA-169131 0.160864 0.794 0 0
Regulation of cortical dendrite branching R-HSA-8985801 0.295865 0.529 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.295865 0.529 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 0.354994 0.450 0 0
Sodium/Proton exchangers R-HSA-425986 0.251195 0.600 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.188743 0.724 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.283453 0.548 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 0.409161 0.388 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.233784 0.631 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.315576 0.501 0 0
Ionotropic activity of kainate receptors R-HSA-451306 0.347359 0.459 0 0
Signaling by APC mutants R-HSA-4839744 0.347359 0.459 0 0
Reelin signalling pathway R-HSA-8866376 0.458781 0.338 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.458781 0.338 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.227175 0.644 0 0
Signaling by AXIN mutants R-HSA-4839735 0.378634 0.422 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.378634 0.422 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.289876 0.538 0 0
Metalloprotease DUBs R-HSA-5689901 0.309341 0.510 0 0
MET activates RAS signaling R-HSA-8851805 0.409261 0.388 0 0
PKB-mediated events R-HSA-109703 0.504238 0.297 0 0
PDE3B signalling R-HSA-165160 0.504238 0.297 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.206676 0.685 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.348576 0.458 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.295747 0.529 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.394866 0.404 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.292428 0.534 0 0
Degradation of CDH1 R-HSA-9766229 0.383701 0.416 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.465104 0.332 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.523391 0.281 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.534327 0.272 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.572843 0.242 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.560429 0.251 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.590272 0.229 0 0
S Phase R-HSA-69242 0.293248 0.533 0 0
RNA Polymerase II Transcription R-HSA-73857 0.491377 0.309 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.219914 0.658 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.153099 0.815 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.580829 0.236 0 0
Co-stimulation by CD28 R-HSA-389356 0.368292 0.434 0 0
Cellular response to chemical stress R-HSA-9711123 0.547536 0.262 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.248119 0.605 0 0
Aggrephagy R-HSA-9646399 0.394866 0.404 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 0.467263 0.330 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.214404 0.669 0 0
Frs2-mediated activation R-HSA-170968 0.439129 0.357 0 0
p75NTR signals via NF-kB R-HSA-193639 0.496253 0.304 0 0
Vesicle-mediated transport R-HSA-5653656 0.550035 0.260 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.458021 0.339 0 0
EGFR downregulation R-HSA-182971 0.227175 0.644 0 0
Cellular responses to stress R-HSA-2262752 0.351505 0.454 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.194054 0.712 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.409261 0.388 0 0
Activation of SMO R-HSA-5635838 0.523391 0.281 0 0
Differentiation of T cells R-HSA-9945266 0.523391 0.281 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.523391 0.281 0 0
Autophagy R-HSA-9612973 0.360383 0.443 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.283453 0.548 0 0
Signal attenuation R-HSA-74749 0.315576 0.501 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.387863 0.411 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.449371 0.347 0 0
Kinesins R-HSA-983189 0.548626 0.261 0 0
Cellular responses to stimuli R-HSA-8953897 0.402940 0.395 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.199215 0.701 0 0
Ub-specific processing proteases R-HSA-5689880 0.420058 0.377 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.199215 0.701 0 0
Negative regulation of MET activity R-HSA-6807004 0.375217 0.426 0 0
Macroautophagy R-HSA-1632852 0.230707 0.637 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.210031 0.678 0 0
Selective autophagy R-HSA-9663891 0.347545 0.459 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.390407 0.408 0 0
Signal regulatory protein family interactions R-HSA-391160 0.210999 0.676 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 0.409161 0.388 0 0
Muscarinic acetylcholine receptors R-HSA-390648 0.458781 0.338 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.504238 0.297 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.552772 0.257 0 0
G2/M Transition R-HSA-69275 0.346332 0.461 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.194022 0.712 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.585092 0.233 0 0
Mitophagy R-HSA-5205647 0.483905 0.315 0 0
Semaphorin interactions R-HSA-373755 0.429975 0.367 0 0
Signaling by NOTCH1 R-HSA-1980143 0.319438 0.496 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.250589 0.601 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.372540 0.429 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.429975 0.367 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.532151 0.274 0 0
G2/M Checkpoints R-HSA-69481 0.589639 0.229 0 0
Activation of BH3-only proteins R-HSA-114452 0.387863 0.411 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.153099 0.815 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.590157 0.229 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.590157 0.229 0 0
Ion transport by P-type ATPases R-HSA-936837 0.444008 0.353 0 0
NGF-stimulated transcription R-HSA-9031628 0.224562 0.649 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.528121 0.277 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.187977 0.726 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.471572 0.326 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.231320 0.636 0 0
Inhibition of membrane repair R-HSA-9635644 0.231320 0.636 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.156295 0.806 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 0.187299 0.727 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 0.188743 0.724 0 0
TNFR1-mediated ceramide production R-HSA-5626978 0.409161 0.388 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.315576 0.501 0 0
Inositol transporters R-HSA-429593 0.458781 0.338 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 0.378634 0.422 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 0.504238 0.297 0 0
Signaling by NODAL R-HSA-1181150 0.375217 0.426 0 0
Maturation of nucleoprotein R-HSA-9683610 0.439129 0.357 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.274962 0.561 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.190078 0.721 0 0
Signaling by FGFR in disease R-HSA-1226099 0.295747 0.529 0 0
Gap junction trafficking and regulation R-HSA-157858 0.383701 0.416 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.467263 0.330 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 0.523391 0.281 0 0
VLDL clearance R-HSA-8964046 0.584024 0.234 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.272525 0.565 0 0
Signaling by KIT in disease R-HSA-9669938 0.444746 0.352 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.324833 0.488 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.387680 0.412 0 0
Signaling by TGFBR3 R-HSA-9839373 0.337578 0.472 0 0
Basigin interactions R-HSA-210991 0.398664 0.399 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.468149 0.330 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.325901 0.487 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 0.549527 0.260 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.499385 0.302 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.538578 0.269 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.167006 0.777 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.387680 0.412 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.574636 0.241 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.574636 0.241 0 0
Potential therapeutics for SARS R-HSA-9679191 0.506980 0.295 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.245800 0.609 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.496253 0.304 0 0
MHC class II antigen presentation R-HSA-2132295 0.540374 0.267 0 0
Death Receptor Signaling R-HSA-73887 0.185233 0.732 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.468149 0.330 0 0
Netrin-1 signaling R-HSA-373752 0.479350 0.319 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.421861 0.375 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.465104 0.332 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 0.295865 0.529 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.283453 0.548 0 0
RET signaling R-HSA-8853659 0.179863 0.745 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 0.504238 0.297 0 0
Relaxin receptors R-HSA-444821 0.504238 0.297 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.496253 0.304 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.446063 0.351 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.523391 0.281 0 0
Regulation of PTEN localization R-HSA-8948747 0.584024 0.234 0 0
Netrin mediated repulsion signals R-HSA-418886 0.584024 0.234 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.573340 0.242 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.592343 0.227 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.398664 0.399 0 0
Interleukin-7 signaling R-HSA-1266695 0.289876 0.538 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.404566 0.393 0 0
TNF signaling R-HSA-75893 0.204180 0.690 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.426818 0.370 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.574636 0.241 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.160919 0.793 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.307540 0.512 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.462709 0.335 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.479350 0.319 0 0
Influenza Infection R-HSA-168255 0.377876 0.423 0 0
NGF processing R-HSA-167060 0.354994 0.450 0 0
Expression and Processing of Neurotrophins R-HSA-9036866 0.354994 0.450 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.188743 0.724 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.458781 0.338 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 0.378634 0.422 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.504238 0.297 0 0
Formation of the anterior neural plate R-HSA-9823739 0.496253 0.304 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.429843 0.367 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.574636 0.241 0 0
Apoptosis R-HSA-109581 0.238914 0.622 0 0
Signaling by ALK R-HSA-201556 0.219914 0.658 0 0
Signaling by NOTCH3 R-HSA-9012852 0.475398 0.323 0 0
IRE1alpha activates chaperones R-HSA-381070 0.393598 0.405 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.519682 0.284 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.585247 0.233 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 0.233784 0.631 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.199894 0.699 0 0
Josephin domain DUBs R-HSA-5689877 0.315576 0.501 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.523391 0.281 0 0
Specification of primordial germ cells R-HSA-9827857 0.304123 0.517 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.347359 0.459 0 0
PECAM1 interactions R-HSA-210990 0.347359 0.459 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 0.504238 0.297 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.545878 0.263 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.496253 0.304 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.446063 0.351 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.584024 0.234 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.552772 0.257 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.501528 0.300 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.584024 0.234 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.490359 0.309 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.572843 0.242 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.196446 0.707 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.453567 0.343 0 0
Synthesis and processing of ENV and VPU R-HSA-171286 0.295865 0.529 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.504238 0.297 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 0.439129 0.357 0 0
Glycolysis R-HSA-70171 0.383492 0.416 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 0.409261 0.388 0 0
Growth hormone receptor signaling R-HSA-982772 0.467263 0.330 0 0
DNA Damage Reversal R-HSA-73942 0.496253 0.304 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 0.458781 0.338 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.483905 0.315 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.593441 0.227 0 0
Programmed Cell Death R-HSA-5357801 0.596484 0.224 0 0
Glucose metabolism R-HSA-70326 0.597466 0.224 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 0.598709 0.223 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.598709 0.223 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.598709 0.223 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.598709 0.223 0 0
Presynaptic function of Kainate receptors R-HSA-500657 0.598709 0.223 0 0
Platelet sensitization by LDL R-HSA-432142 0.598709 0.223 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.598709 0.223 0 0
Mismatch Repair R-HSA-5358508 0.598709 0.223 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.604463 0.219 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.606348 0.217 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.611256 0.214 0 0
DAP12 signaling R-HSA-2424491 0.611256 0.214 0 0
Cellular response to hypoxia R-HSA-1234174 0.616885 0.210 0 0
Smooth Muscle Contraction R-HSA-445355 0.618860 0.208 0 0
phospho-PLA2 pathway R-HSA-111995 0.618967 0.208 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.618967 0.208 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 0.618967 0.208 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 0.618967 0.208 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.618967 0.208 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.618967 0.208 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 0.618967 0.208 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.618967 0.208 0 0
Activation of RAS in B cells R-HSA-1169092 0.618967 0.208 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 0.618967 0.208 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 0.618967 0.208 0 0
Adrenoceptors R-HSA-390696 0.618967 0.208 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 0.618967 0.208 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.621740 0.206 0 0
Regulation of signaling by CBL R-HSA-912631 0.621740 0.206 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 0.621740 0.206 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.621740 0.206 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.621740 0.206 0 0
Other interleukin signaling R-HSA-449836 0.621740 0.206 0 0
The NLRP3 inflammasome R-HSA-844456 0.621740 0.206 0 0
Maturation of nucleoprotein R-HSA-9694631 0.621740 0.206 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.622588 0.206 0 0
FOXO-mediated transcription R-HSA-9614085 0.626554 0.203 0 0
Reproduction R-HSA-1474165 0.627308 0.203 0 0
PCP/CE pathway R-HSA-4086400 0.627981 0.202 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 0.629572 0.201 0 0
Hedgehog 'off' state R-HSA-5610787 0.637051 0.196 0 0
Base Excision Repair R-HSA-73884 0.638078 0.195 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.638182 0.195 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.638182 0.195 0 0
Sensory processing of sound R-HSA-9659379 0.639791 0.194 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.643736 0.191 0 0
Nephrin family interactions R-HSA-373753 0.643736 0.191 0 0
Protein hydroxylation R-HSA-9629569 0.643736 0.191 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.643736 0.191 0 0
G alpha (z) signalling events R-HSA-418597 0.646701 0.189 0 0
MAPK1 (ERK2) activation R-HSA-112411 0.650977 0.186 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.650977 0.186 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 0.650977 0.186 0 0
Lipophagy R-HSA-9613354 0.650977 0.186 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 0.650977 0.186 0 0
Unwinding of DNA R-HSA-176974 0.650977 0.186 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 0.650977 0.186 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.650977 0.186 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.650977 0.186 0 0
Regulation of signaling by NODAL R-HSA-1433617 0.650977 0.186 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.650977 0.186 0 0
Interleukin-1 processing R-HSA-448706 0.650977 0.186 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.650977 0.186 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 0.650977 0.186 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.651381 0.186 0 0
Signaling by FGFR2 R-HSA-5654738 0.651381 0.186 0 0
Signaling by FGFR4 R-HSA-5654743 0.653349 0.185 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.654906 0.184 0 0
PI Metabolism R-HSA-1483255 0.657550 0.182 0 0
Ion homeostasis R-HSA-5578775 0.660131 0.180 0 0
NRAGE signals death through JNK R-HSA-193648 0.660131 0.180 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.660131 0.180 0 0
Signaling by ROBO receptors R-HSA-376176 0.662249 0.179 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.664381 0.178 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.664708 0.177 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.664708 0.177 0 0
Signalling to RAS R-HSA-167044 0.664708 0.177 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.664708 0.177 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.664708 0.177 0 0
ERK/MAPK targets R-HSA-198753 0.664708 0.177 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.664708 0.177 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.664708 0.177 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.665582 0.177 0 0
Cyclin D associated events in G1 R-HSA-69231 0.668084 0.175 0 0
G1 Phase R-HSA-69236 0.668084 0.175 0 0
Gap junction trafficking R-HSA-190828 0.668084 0.175 0 0
Signaling by NOTCH R-HSA-157118 0.676799 0.170 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.680300 0.167 0 0
Folding of actin by CCT/TriC R-HSA-390450 0.680300 0.167 0 0
Binding and entry of HIV virion R-HSA-173107 0.680300 0.167 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.680300 0.167 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 0.680300 0.167 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 0.680300 0.167 0 0
Pexophagy R-HSA-9664873 0.680300 0.167 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.680300 0.167 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.680869 0.167 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.682384 0.166 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.682384 0.166 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.682384 0.166 0 0
Signaling by FGFR3 R-HSA-5654741 0.682384 0.166 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.682384 0.166 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.682384 0.166 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.684672 0.165 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.684672 0.165 0 0
Attachment and Entry R-HSA-9694614 0.684672 0.165 0 0
tRNA processing R-HSA-72306 0.685026 0.164 0 0
RSV-host interactions R-HSA-9833110 0.687012 0.163 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.690510 0.161 0 0
Hedgehog 'on' state R-HSA-5632684 0.690510 0.161 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.695162 0.158 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.696246 0.157 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.696246 0.157 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.696477 0.157 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.696747 0.157 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.696747 0.157 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.697001 0.157 0 0
Extension of Telomeres R-HSA-180786 0.698399 0.156 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.702159 0.154 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.702166 0.154 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.702166 0.154 0 0
rRNA processing R-HSA-72312 0.702814 0.153 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.703651 0.153 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.703651 0.153 0 0
LDL clearance R-HSA-8964038 0.703651 0.153 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.703651 0.153 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.707161 0.150 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.707161 0.150 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 0.707161 0.150 0 0
LGI-ADAM interactions R-HSA-5682910 0.707161 0.150 0 0
Dissolution of Fibrin Clot R-HSA-75205 0.707161 0.150 0 0
vRNA Synthesis R-HSA-192814 0.707161 0.150 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.707161 0.150 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.707161 0.150 0 0
Transport of RCbl within the body R-HSA-9758890 0.707161 0.150 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 0.707161 0.150 0 0
Interleukin-2 signaling R-HSA-9020558 0.707161 0.150 0 0
Mitochondrial biogenesis R-HSA-1592230 0.710908 0.148 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.712018 0.148 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.719796 0.143 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.719796 0.143 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.721667 0.142 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.721667 0.142 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.721667 0.142 0 0
Metal ion SLC transporters R-HSA-425410 0.722653 0.141 0 0
Interleukin-1 family signaling R-HSA-446652 0.725875 0.139 0 0
G1/S-Specific Transcription R-HSA-69205 0.726689 0.139 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.726689 0.139 0 0
RUNX2 regulates bone development R-HSA-8941326 0.726689 0.139 0 0
Muscle contraction R-HSA-397014 0.730094 0.137 0 0
DS-GAG biosynthesis R-HSA-2022923 0.731766 0.136 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.731766 0.136 0 0
NF-kB is activated and signals survival R-HSA-209560 0.731766 0.136 0 0
ERKs are inactivated R-HSA-202670 0.731766 0.136 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 0.731766 0.136 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.731766 0.136 0 0
Sodium/Calcium exchangers R-HSA-425561 0.731766 0.136 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.731766 0.136 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.733584 0.135 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.733584 0.135 0 0
Regulation of insulin secretion R-HSA-422356 0.738165 0.132 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.738750 0.132 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.738750 0.132 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.738750 0.132 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.738750 0.132 0 0
Neurodegenerative Diseases R-HSA-8863678 0.738750 0.132 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.738750 0.132 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.741044 0.130 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.741044 0.130 0 0
Chromosome Maintenance R-HSA-73886 0.744213 0.128 0 0
UCH proteinases R-HSA-5689603 0.744239 0.128 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.744624 0.128 0 0
Generic Transcription Pathway R-HSA-212436 0.745128 0.128 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.747317 0.126 0 0
PPARA activates gene expression R-HSA-1989781 0.747573 0.126 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.752751 0.123 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.754134 0.123 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.754264 0.122 0 0
Elastic fibre formation R-HSA-1566948 0.754264 0.122 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.754264 0.122 0 0
Maple Syrup Urine Disease R-HSA-9865114 0.754305 0.122 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 0.754305 0.122 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 0.754305 0.122 0 0
Scavenging by Class F Receptors R-HSA-3000484 0.754305 0.122 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 0.754305 0.122 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.754305 0.122 0 0
Signaling by LTK R-HSA-9842663 0.754305 0.122 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.754305 0.122 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.754305 0.122 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.754305 0.122 0 0
OAS antiviral response R-HSA-8983711 0.754305 0.122 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.754305 0.122 0 0
Interleukin-15 signaling R-HSA-8983432 0.754305 0.122 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.754929 0.122 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.757909 0.120 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.759855 0.119 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.761390 0.118 0 0
HCMV Late Events R-HSA-9610379 0.761390 0.118 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.763746 0.117 0 0
Stabilization of p53 R-HSA-69541 0.767188 0.115 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.767188 0.115 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.767188 0.115 0 0
Formation of the cornified envelope R-HSA-6809371 0.767423 0.115 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.770235 0.113 0 0
Sphingolipid catabolism R-HSA-9845614 0.770235 0.113 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.770235 0.113 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.770267 0.113 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.773078 0.112 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.774952 0.111 0 0
Adenylate cyclase activating pathway R-HSA-170660 0.774952 0.111 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.774952 0.111 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 0.774952 0.111 0 0
Processing of SMDT1 R-HSA-8949664 0.774952 0.111 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.774952 0.111 0 0
CD28 dependent Vav1 pathway R-HSA-389359 0.774952 0.111 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.779553 0.108 0 0
Diseases of Immune System R-HSA-5260271 0.779553 0.108 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.779553 0.108 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.782131 0.107 0 0
Integration of energy metabolism R-HSA-163685 0.783580 0.106 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.784701 0.105 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.784701 0.105 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.784701 0.105 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.784701 0.105 0 0
Maturation of hRSV A proteins R-HSA-9828806 0.784701 0.105 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.788207 0.103 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.788350 0.103 0 0
Signaling by Insulin receptor R-HSA-74752 0.788931 0.103 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.791371 0.102 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.791371 0.102 0 0
Removal of the Flap Intermediate R-HSA-69166 0.793865 0.100 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 0.793865 0.100 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 0.793865 0.100 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.793865 0.100 0 0
Hydrolysis of LPC R-HSA-1483115 0.793865 0.100 0 0
Prolactin receptor signaling R-HSA-1170546 0.793865 0.100 0 0
Acyl chain remodeling of CL R-HSA-1482798 0.793865 0.100 0 0
Zinc transporters R-HSA-435354 0.793865 0.100 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.794764 0.100 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.795813 0.099 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.795813 0.099 0 0
Signaling by Hedgehog R-HSA-5358351 0.796911 0.099 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.798359 0.098 0 0
Telomere Extension By Telomerase R-HSA-171319 0.798359 0.098 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.798359 0.098 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.798359 0.098 0 0
Inflammasomes R-HSA-622312 0.798359 0.098 0 0
Co-inhibition by PD-1 R-HSA-389948 0.799928 0.097 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.802657 0.095 0 0
HCMV Infection R-HSA-9609646 0.804469 0.094 0 0
Parasite infection R-HSA-9664407 0.809635 0.092 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.809635 0.092 0 0
Leishmania phagocytosis R-HSA-9664417 0.809635 0.092 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.811189 0.091 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 0.811189 0.091 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.811189 0.091 0 0
G beta:gamma signalling through BTK R-HSA-8964315 0.811189 0.091 0 0
Translesion synthesis by REV1 R-HSA-110312 0.811189 0.091 0 0
Telomere C-strand synthesis initiation R-HSA-174430 0.811189 0.091 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.811189 0.091 0 0
Biotin transport and metabolism R-HSA-196780 0.811189 0.091 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.811189 0.091 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.811189 0.091 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.811189 0.091 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.811189 0.091 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.811189 0.091 0 0
Signaling by FGFR1 R-HSA-5654736 0.811219 0.091 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.811243 0.091 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.811243 0.091 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.811243 0.091 0 0
Platelet calcium homeostasis R-HSA-418360 0.811243 0.091 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 0.811243 0.091 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.811243 0.091 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.812318 0.090 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.812526 0.090 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.812526 0.090 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.813425 0.090 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.822677 0.085 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.822677 0.085 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.822677 0.085 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 0.823387 0.084 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.823387 0.084 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.824199 0.084 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 0.827058 0.082 0 0
Translesion synthesis by POLI R-HSA-5656121 0.827058 0.082 0 0
Phosphorylation of the APC/C R-HSA-176412 0.827058 0.082 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.827058 0.082 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 0.827058 0.082 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 0.827058 0.082 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.827058 0.082 0 0
Killing mechanisms R-HSA-9664420 0.827058 0.082 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 0.827058 0.082 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.827058 0.082 0 0
Virus Assembly and Release R-HSA-168268 0.827058 0.082 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.829038 0.081 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.829038 0.081 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.830769 0.081 0 0
DAP12 interactions R-HSA-2172127 0.833471 0.079 0 0
RMTs methylate histone arginines R-HSA-3214858 0.833471 0.079 0 0
Telomere Maintenance R-HSA-157579 0.833650 0.079 0 0
TCR signaling R-HSA-202403 0.837197 0.077 0 0
Regulation of beta-cell development R-HSA-186712 0.837850 0.077 0 0
Signaling by FGFR R-HSA-190236 0.840318 0.076 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.841129 0.075 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.841129 0.075 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.841595 0.075 0 0
Translesion synthesis by POLK R-HSA-5655862 0.841595 0.075 0 0
Phase 2 - plateau phase R-HSA-5576893 0.841595 0.075 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.841595 0.075 0 0
Fibronectin matrix formation R-HSA-1566977 0.841595 0.075 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.841595 0.075 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.841595 0.075 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.841595 0.075 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.841595 0.075 0 0
tRNA modification in the mitochondrion R-HSA-6787450 0.841595 0.075 0 0
Synthesis of PG R-HSA-1483148 0.841595 0.075 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 0.841595 0.075 0 0
Coenzyme A biosynthesis R-HSA-196783 0.841595 0.075 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.841595 0.075 0 0
SARS-CoV Infections R-HSA-9679506 0.842551 0.074 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.842780 0.074 0 0
Nucleosome assembly R-HSA-774815 0.842780 0.074 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.842780 0.074 0 0
Signaling by NOTCH4 R-HSA-9013694 0.844348 0.073 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.844908 0.073 0 0
Signaling by WNT in cancer R-HSA-4791275 0.845588 0.073 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.845588 0.073 0 0
Transmission across Chemical Synapses R-HSA-112315 0.848715 0.071 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.849510 0.071 0 0
Diseases of DNA repair R-HSA-9675135 0.851634 0.070 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.852073 0.070 0 0
MAP kinase activation R-HSA-450294 0.853798 0.069 0 0
Aquaporin-mediated transport R-HSA-445717 0.853798 0.069 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 0.854910 0.068 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.854910 0.068 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.854910 0.068 0 0
Glycogen storage diseases R-HSA-3229121 0.854910 0.068 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.854910 0.068 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.854910 0.068 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 0.854910 0.068 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.854910 0.068 0 0
Cardiogenesis R-HSA-9733709 0.855710 0.068 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.855710 0.068 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.855710 0.068 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.862596 0.064 0 0
Gastrulation R-HSA-9758941 0.864470 0.063 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.865222 0.063 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.865222 0.063 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.865222 0.063 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.867107 0.062 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 0.867107 0.062 0 0
Apoptotic factor-mediated response R-HSA-111471 0.867107 0.062 0 0
Tie2 Signaling R-HSA-210993 0.867107 0.062 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.868393 0.061 0 0
Signaling by PTK6 R-HSA-8848021 0.868393 0.061 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.870302 0.060 0 0
G alpha (12/13) signalling events R-HSA-416482 0.871573 0.060 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 0.874155 0.058 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.874155 0.058 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.874155 0.058 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.874155 0.058 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.874155 0.058 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.874155 0.058 0 0
Signal amplification R-HSA-392518 0.874155 0.058 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.874155 0.058 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.875634 0.058 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.875634 0.058 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.878279 0.056 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.878279 0.056 0 0
Translesion Synthesis by POLH R-HSA-110320 0.878279 0.056 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.878279 0.056 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.878279 0.056 0 0
Toll-like Receptor Cascades R-HSA-168898 0.878899 0.056 0 0
Protein folding R-HSA-391251 0.881640 0.055 0 0
Regulation of Apoptosis R-HSA-169911 0.882540 0.054 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.882540 0.054 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.882540 0.054 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.882540 0.054 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.882540 0.054 0 0
PERK regulates gene expression R-HSA-381042 0.882540 0.054 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.884712 0.053 0 0
SLC transporter disorders R-HSA-5619102 0.885024 0.053 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.888512 0.051 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.888512 0.051 0 0
Glycogen synthesis R-HSA-3322077 0.888512 0.051 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.888512 0.051 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 0.888512 0.051 0 0
Acyl chain remodelling of PI R-HSA-1482922 0.888512 0.051 0 0
Pregnenolone biosynthesis R-HSA-196108 0.888512 0.051 0 0
HSF1 activation R-HSA-3371511 0.890405 0.050 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.890405 0.050 0 0
Glycosphingolipid transport R-HSA-9845576 0.890405 0.050 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.890405 0.050 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.890405 0.050 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.896125 0.048 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.896125 0.048 0 0
Degradation of DVL R-HSA-4641258 0.897778 0.047 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.897778 0.047 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.897886 0.047 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.897886 0.047 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 0.897886 0.047 0 0
Acyl chain remodelling of PG R-HSA-1482925 0.897886 0.047 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 0.897886 0.047 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.900360 0.046 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.902248 0.045 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.904231 0.044 0 0
tRNA processing in the mitochondrion R-HSA-6785470 0.904687 0.044 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.904880 0.043 0 0
CS-GAG biosynthesis R-HSA-2022870 0.906472 0.043 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.906472 0.043 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.906472 0.043 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.906472 0.043 0 0
Serine metabolism R-HSA-977347 0.906472 0.043 0 0
Glutathione synthesis and recycling R-HSA-174403 0.906472 0.043 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.906472 0.043 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.906472 0.043 0 0
Assembly Of The HIV Virion R-HSA-175474 0.906472 0.043 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.909165 0.041 0 0
Interleukin-17 signaling R-HSA-448424 0.910004 0.041 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.911158 0.040 0 0
RAS processing R-HSA-9648002 0.911158 0.040 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.911158 0.040 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.912096 0.040 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.913527 0.039 0 0
Paracetamol ADME R-HSA-9753281 0.913527 0.039 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.914337 0.039 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 0.914337 0.039 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.914337 0.039 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.914337 0.039 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 0.914337 0.039 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.914881 0.039 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.914945 0.039 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.914945 0.039 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.914945 0.039 0 0
Interferon Signaling R-HSA-913531 0.915362 0.038 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.917006 0.038 0 0
Glycogen metabolism R-HSA-8982491 0.917214 0.038 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.917214 0.038 0 0
rRNA processing in the mitochondrion R-HSA-8868766 0.917214 0.038 0 0
Interleukin-2 family signaling R-HSA-451927 0.917214 0.038 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 0.917214 0.038 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.918711 0.037 0 0
Signaling by Interleukins R-HSA-449147 0.918774 0.037 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.919673 0.036 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.920562 0.036 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.921540 0.035 0 0
Termination of O-glycan biosynthesis R-HSA-977068 0.921540 0.035 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.921540 0.035 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.921540 0.035 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.921540 0.035 0 0
Mitochondrial mRNA modification R-HSA-9937008 0.921540 0.035 0 0
Carnitine shuttle R-HSA-200425 0.921540 0.035 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.922881 0.035 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.922881 0.035 0 0
Maturation of spike protein R-HSA-9694548 0.922881 0.035 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.926516 0.033 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 0.928139 0.032 0 0
Complex III assembly R-HSA-9865881 0.928139 0.032 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.928139 0.032 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.928139 0.032 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 0.928139 0.032 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.928139 0.032 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.928181 0.032 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.928181 0.032 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.928181 0.032 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.928181 0.032 0 0
Translation of Structural Proteins R-HSA-9683701 0.928181 0.032 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.930895 0.031 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.932603 0.030 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.932603 0.030 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.933135 0.030 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.933135 0.030 0 0
Depyrimidination R-HSA-73928 0.933135 0.030 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.934183 0.030 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.934183 0.030 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 0.934183 0.030 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.934183 0.030 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.934183 0.030 0 0
Laminin interactions R-HSA-3000157 0.934183 0.030 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.934183 0.030 0 0
tRNA Aminoacylation R-HSA-379724 0.936725 0.028 0 0
Translation of Structural Proteins R-HSA-9694635 0.939482 0.027 0 0
MET activates PTK2 signaling R-HSA-8874081 0.939718 0.027 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 0.939718 0.027 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.939718 0.027 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.939718 0.027 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.939718 0.027 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.939718 0.027 0 0
Suppression of phagosomal maturation R-HSA-9637687 0.939718 0.027 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.940613 0.027 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.940613 0.027 0 0
Surfactant metabolism R-HSA-5683826 0.942088 0.026 0 0
Amine ligand-binding receptors R-HSA-375280 0.942088 0.026 0 0
Interleukin-10 signaling R-HSA-6783783 0.942888 0.026 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.943660 0.025 0 0
Packaging Of Telomere Ends R-HSA-171306 0.944789 0.025 0 0
Cristae formation R-HSA-8949613 0.944789 0.025 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 0.944789 0.025 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.944789 0.025 0 0
Triglyceride biosynthesis R-HSA-75109 0.944789 0.025 0 0
Synthesis of PE R-HSA-1483213 0.944789 0.025 0 0
Insulin processing R-HSA-264876 0.944789 0.025 0 0
Parasitic Infection Pathways R-HSA-9824443 0.945713 0.024 0 0
Leishmania infection R-HSA-9658195 0.945713 0.024 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.946126 0.024 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 0.946126 0.024 0 0
Synthesis of DNA R-HSA-69239 0.948279 0.023 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.949433 0.023 0 0
Iron assimilation using enterobactin R-HSA-9638334 0.949433 0.023 0 0
Pyrimidine salvage R-HSA-73614 0.949433 0.023 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.949894 0.022 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.949894 0.022 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.949894 0.022 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.949894 0.022 1 1
Developmental Biology R-HSA-1266738 0.950372 0.022 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.950863 0.022 0 0
Ion channel transport R-HSA-983712 0.951742 0.021 0 0
Amyloid fiber formation R-HSA-977225 0.952082 0.021 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.953331 0.021 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.953410 0.021 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.953410 0.021 0 0
Synthesis of PC R-HSA-1483191 0.953410 0.021 0 0
Late endosomal microautophagy R-HSA-9615710 0.953687 0.021 0 0
DNA methylation R-HSA-5334118 0.953687 0.021 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.953687 0.021 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.954698 0.020 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.956572 0.019 0 0
Intraflagellar transport R-HSA-5620924 0.956689 0.019 0 0
Activation of the pre-replicative complex R-HSA-68962 0.957583 0.019 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.957583 0.019 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.959649 0.018 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.959746 0.018 0 0
Chemokine receptors bind chemokines R-HSA-380108 0.959746 0.018 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.959897 0.018 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.961152 0.017 0 0
Budding and maturation of HIV virion R-HSA-162588 0.961152 0.017 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.961152 0.017 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.961152 0.017 0 0
Cargo concentration in the ER R-HSA-5694530 0.961152 0.017 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.961347 0.017 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.961347 0.017 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.961347 0.017 0 0
G1/S Transition R-HSA-69206 0.961347 0.017 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.962119 0.017 0 0
HS-GAG degradation R-HSA-2024096 0.964421 0.016 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.964421 0.016 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.964421 0.016 0 0
Platelet degranulation R-HSA-114608 0.965035 0.015 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.965251 0.015 0 0
Meiotic recombination R-HSA-912446 0.965251 0.015 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.965251 0.015 0 0
Complex IV assembly R-HSA-9864848 0.965251 0.015 0 0
The phototransduction cascade R-HSA-2514856 0.965251 0.015 1 0
Neuronal System R-HSA-112316 0.965959 0.015 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.967414 0.014 0 0
Interleukin-1 signaling R-HSA-9020702 0.967594 0.014 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.967725 0.014 0 0
Orc1 removal from chromatin R-HSA-68949 0.967725 0.014 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.968978 0.014 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.968978 0.014 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.970028 0.013 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.970028 0.013 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.970028 0.013 0 0
CS/DS degradation R-HSA-2024101 0.970156 0.013 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.970156 0.013 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.970156 0.013 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 0.970156 0.013 0 0
Heme degradation R-HSA-189483 0.970156 0.013 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.970805 0.013 0 0
ER-Phagosome pathway R-HSA-1236974 0.972107 0.012 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.972173 0.012 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.972173 0.012 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 0.972668 0.012 0 0
Calnexin/calreticulin cycle R-HSA-901042 0.972668 0.012 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.972668 0.012 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.972668 0.012 0 0
Signaling by NOTCH2 R-HSA-1980145 0.972668 0.012 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.972668 0.012 0 0
Hyaluronan metabolism R-HSA-2142845 0.972668 0.012 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.972684 0.012 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.972838 0.012 0 0
Signaling by ERBB4 R-HSA-1236394 0.974594 0.011 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.974968 0.011 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.974968 0.011 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.974968 0.011 0 0
Extracellular matrix organization R-HSA-1474244 0.975084 0.011 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.976027 0.011 0 0
Developmental Cell Lineages R-HSA-9734767 0.976722 0.010 0 0
HS-GAG biosynthesis R-HSA-2022928 0.977075 0.010 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.977075 0.010 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.977075 0.010 0 0
GPVI-mediated activation cascade R-HSA-114604 0.977075 0.010 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.978209 0.010 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.979004 0.009 0 0
Degradation of AXIN R-HSA-4641257 0.979004 0.009 0 0
Cleavage of the damaged purine R-HSA-110331 0.979004 0.009 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 0.979004 0.009 0 0
NCAM1 interactions R-HSA-419037 0.979004 0.009 0 0
Metabolism of folate and pterines R-HSA-196757 0.979004 0.009 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.979361 0.009 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.979525 0.009 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.979548 0.009 0 0
Stimuli-sensing channels R-HSA-2672351 0.979548 0.009 0 0
Phospholipid metabolism R-HSA-1483257 0.979844 0.009 0 0
Integrin cell surface interactions R-HSA-216083 0.980594 0.009 0 0
Cholesterol biosynthesis R-HSA-191273 0.980594 0.009 0 0
Collagen formation R-HSA-1474290 0.980766 0.008 0 0
Depurination R-HSA-73927 0.980772 0.008 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 0.980772 0.008 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.980772 0.008 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.980772 0.008 0 0
Peroxisomal protein import R-HSA-9033241 0.980856 0.008 0 0
DNA Replication R-HSA-69306 0.982378 0.008 0 0
Pentose phosphate pathway R-HSA-71336 0.982390 0.008 0 0
PKR-mediated signaling R-HSA-9833482 0.983061 0.007 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.983435 0.007 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.983873 0.007 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.984075 0.007 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.984161 0.007 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.984735 0.007 0 0
G alpha (s) signalling events R-HSA-418555 0.985175 0.006 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.985175 0.006 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.985226 0.006 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.985230 0.006 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.985230 0.006 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.985230 0.006 0 0
Aflatoxin activation and detoxification R-HSA-5423646 0.985230 0.006 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.986207 0.006 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.986474 0.006 0 0
Intra-Golgi traffic R-HSA-6811438 0.986474 0.006 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.986884 0.006 0 0
Activation of GABAB receptors R-HSA-991365 0.987613 0.005 0 0
GABA B receptor activation R-HSA-977444 0.987613 0.005 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.987845 0.005 0 0
Defective pyroptosis R-HSA-9710421 0.988656 0.005 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.988656 0.005 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.988656 0.005 0 0
Cardiac conduction R-HSA-5576891 0.988737 0.005 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.989539 0.005 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.989611 0.005 0 0
Proteasome assembly R-HSA-9907900 0.989611 0.005 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 0.989611 0.005 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.989611 0.005 0 0
Adaptive Immune System R-HSA-1280218 0.989941 0.004 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.990486 0.004 0 0
Somitogenesis R-HSA-9824272 0.990486 0.004 0 0
Diseases of programmed cell death R-HSA-9645723 0.990900 0.004 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.991287 0.004 0 0
Neutrophil degranulation R-HSA-6798695 0.991387 0.004 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 0.992021 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 0.992089 0.003 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.992142 0.003 0 0
Platelet homeostasis R-HSA-418346 0.992152 0.003 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.992626 0.003 0 0
Plasma lipoprotein remodeling R-HSA-8963899 0.992693 0.003 0 0
Sphingolipid metabolism R-HSA-428157 0.992785 0.003 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.992993 0.003 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.993141 0.003 0 0
Viral Infection Pathways R-HSA-9824446 0.993328 0.003 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.993480 0.003 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.993596 0.003 0 0
Azathioprine ADME R-HSA-9748787 0.993872 0.003 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.994033 0.003 0 0
Branched-chain amino acid catabolism R-HSA-70895 0.994389 0.002 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.994389 0.002 0 0
Cellular response to starvation R-HSA-9711097 0.994401 0.002 0 0
Keratinization R-HSA-6805567 0.994686 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.994714 0.002 0 0
Interleukin-12 signaling R-HSA-9020591 0.994785 0.002 0 0
Post-translational protein modification R-HSA-597592 0.994994 0.002 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.995691 0.002 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 0.996054 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.996214 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.996379 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 0.996630 0.001 0 0
Synthesis of PA R-HSA-1483166 0.996691 0.001 0 0
Dectin-2 family R-HSA-5621480 0.996691 0.001 0 0
Peroxisomal lipid metabolism R-HSA-390918 0.997206 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 0.997225 0.001 0 0
Triglyceride metabolism R-HSA-8979227 0.997225 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.997230 0.001 0 0
Protein localization R-HSA-9609507 0.997298 0.001 0 0
GABA receptor activation R-HSA-977443 0.997459 0.001 0 0
Glutathione conjugation R-HSA-156590 0.997459 0.001 0 0
Metabolism of polyamines R-HSA-351202 0.997459 0.001 0 0
Neddylation R-HSA-8951664 0.997583 0.001 0 0
Collagen degradation R-HSA-1442490 0.997673 0.001 0 0
Endogenous sterols R-HSA-211976 0.997673 0.001 0 0
Nucleotide salvage R-HSA-8956321 0.997673 0.001 0 0
Hemostasis R-HSA-109582 0.997689 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.997795 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.997795 0.001 0 0
Mitochondrial protein import R-HSA-1268020 0.997869 0.001 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.997869 0.001 0 0
Interleukin-12 family signaling R-HSA-447115 0.997961 0.001 0 0
Peptide chain elongation R-HSA-156902 0.998115 0.001 0 0
Interferon gamma signaling R-HSA-877300 0.998136 0.001 0 0
Xenobiotics R-HSA-211981 0.998214 0.001 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.998370 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.998485 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.998502 0.001 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.998626 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 0.998628 0.001 0 0
Nicotinate metabolism R-HSA-196807 0.998628 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 0.998628 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 0.998744 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.998744 0.001 0 0
FCGR activation R-HSA-2029481 0.998828 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.998947 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 0.998947 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 0.998947 0.000 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.999000 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.999036 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 0.999036 0.000 0 0
ECM proteoglycans R-HSA-3000178 0.999036 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 0.999036 0.000 0 0
Metabolism of porphyrins R-HSA-189445 0.999036 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.999077 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 0.999077 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 0.999096 0.000 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.999120 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 0.999148 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 0.999192 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 0.999273 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 0.999369 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 0.999429 0.000 0 0
ABC transporter disorders R-HSA-5619084 0.999480 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.999513 0.000 0 0
Viral mRNA Translation R-HSA-192823 0.999513 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.999524 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.999601 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.999674 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 0.999690 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 0.999723 0.000 0 0
G alpha (i) signalling events R-HSA-418594 0.999726 0.000 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.999783 0.000 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.999783 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.999783 0.000 0 0
Pyruvate metabolism R-HSA-70268 0.999785 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.999835 0.000 0 0
Downstream TCR signaling R-HSA-202424 0.999835 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999876 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 0.999909 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.999918 0.000 0 0
Immune System R-HSA-168256 0.999925 0.000 0 0
G alpha (q) signalling events R-HSA-416476 0.999927 0.000 0 0
Visual phototransduction R-HSA-2187338 0.999941 0.000 1 0
Metabolism of steroids R-HSA-8957322 0.999950 0.000 0 0
Translation R-HSA-72766 0.999960 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999970 0.000 0 0
Antimicrobial peptides R-HSA-6803157 0.999980 0.000 0 0
Mitochondrial translation R-HSA-5368287 0.999983 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.999988 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999990 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.999990 0.000 0 0
Infectious disease R-HSA-5663205 0.999992 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.999993 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 0.999994 0.000 0 0
Arachidonate metabolism R-HSA-2142753 0.999995 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.999996 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999997 0.000 0 0
Diseases of glycosylation R-HSA-3781865 0.999997 0.000 0 0
GPCR downstream signalling R-HSA-388396 0.999998 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 0.999999 0.000 0 0
O-linked glycosylation R-HSA-5173105 0.999999 0.000 0 0
Innate Immune System R-HSA-168249 0.999999 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000 0.000 0 0
Drug ADME R-HSA-9748784 1.000000 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Disease R-HSA-1643685 1.000000 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 -0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 1 0
Biological oxidations R-HSA-211859 1.000000 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 4.074519e-14 13.390 0 0
Cell Cycle, Mitotic R-HSA-69278 4.812817e-12 11.318 0 0
M Phase R-HSA-68886 8.600121e-12 11.065 0 0
Mitotic Prometaphase R-HSA-68877 2.731104e-11 10.564 0 0
Metabolism of RNA R-HSA-8953854 1.182545e-10 9.927 0 0
Cellular response to heat stress R-HSA-3371556 1.749275e-09 8.757 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.447851e-09 8.264 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.657949e-08 7.780 0 0
Attenuation phase R-HSA-3371568 1.851109e-08 7.733 0 0
Mitotic Anaphase R-HSA-68882 2.088786e-08 7.680 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.391692e-08 7.621 0 0
Separation of Sister Chromatids R-HSA-2467813 3.634529e-08 7.440 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.188574e-08 7.208 0 0
Cellular responses to stress R-HSA-2262752 7.139040e-08 7.146 0 0
Cellular responses to stimuli R-HSA-8953897 1.224240e-07 6.912 0 0
HSF1-dependent transactivation R-HSA-3371571 1.879228e-07 6.726 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.826652e-07 6.549 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.647665e-07 6.438 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.723205e-07 6.242 0 0
Signaling by ALK in cancer R-HSA-9700206 5.723205e-07 6.242 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.291137e-07 6.032 0 0
HSF1 activation R-HSA-3371511 2.071487e-06 5.684 0 0
mRNA Splicing R-HSA-72172 3.904676e-06 5.408 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.434458e-06 5.265 0 0
Mitotic Spindle Checkpoint R-HSA-69618 9.006948e-06 5.045 0 0
Apoptotic execution phase R-HSA-75153 1.055073e-05 4.977 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.124534e-05 4.949 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.124534e-05 4.949 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.598608e-05 4.796 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.875609e-05 4.727 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.489782e-05 4.604 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 5.973005e-05 4.224 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.063677e-05 4.151 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 7.063677e-05 4.151 0 0
Cell Cycle Checkpoints R-HSA-69620 8.920148e-05 4.050 0 0
PKR-mediated signaling R-HSA-9833482 8.870752e-05 4.052 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.921541e-05 4.050 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.314228e-05 4.031 0 0
G2/M Transition R-HSA-69275 1.006255e-04 3.997 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.222278e-04 3.913 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.321855e-04 3.879 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.321855e-04 3.879 0 0
Recycling pathway of L1 R-HSA-437239 1.505527e-04 3.822 0 0
Chromatin organization R-HSA-4839726 1.492681e-04 3.826 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.556408e-04 3.808 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.779692e-04 3.750 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.868603e-04 3.728 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.951160e-04 3.710 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.121888e-04 3.673 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.165823e-04 3.664 0 0
Influenza Infection R-HSA-168255 2.097670e-04 3.678 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.371784e-04 3.625 0 0
Nuclear import of Rev protein R-HSA-180746 2.720379e-04 3.565 0 0
Chromatin modifying enzymes R-HSA-3247509 2.846493e-04 3.546 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.154842e-04 3.501 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.154842e-04 3.501 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.496773e-04 3.456 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.776730e-04 3.423 0 0
HIV Life Cycle R-HSA-162587 3.834959e-04 3.416 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.794869e-04 3.319 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.246410e-04 3.280 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.232366e-04 3.281 0 0
ChREBP activates metabolic gene expression R-HSA-163765 5.403825e-04 3.267 0 0
Translation initiation complex formation R-HSA-72649 5.486478e-04 3.261 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.550053e-04 3.256 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.930609e-04 3.227 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.963595e-04 3.224 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.963595e-04 3.224 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.132965e-04 3.147 0 0
Centrosome maturation R-HSA-380287 7.374026e-04 3.132 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.404867e-04 3.130 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.464547e-04 3.127 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.464547e-04 3.127 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 7.823197e-04 3.107 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 8.058318e-04 3.094 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 8.563865e-04 3.067 0 0
Aggrephagy R-HSA-9646399 9.477770e-04 3.023 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.477770e-04 3.023 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.681687e-04 3.014 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.046280e-03 2.980 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.045708e-03 2.981 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.045773e-03 2.981 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.045773e-03 2.981 0 0
Regulation of TP53 Activity R-HSA-5633007 1.005946e-03 2.997 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.054102e-03 2.977 0 0
Cilium Assembly R-HSA-5617833 1.062718e-03 2.974 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.209084e-03 2.918 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.296951e-03 2.887 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.296951e-03 2.887 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.254793e-03 2.901 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.383019e-03 2.859 0 0
Kinesins R-HSA-983189 1.411958e-03 2.850 0 0
L1CAM interactions R-HSA-373760 1.413089e-03 2.850 0 0
rRNA processing R-HSA-72312 1.439413e-03 2.842 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.594938e-03 2.797 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.638821e-03 2.785 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.703713e-03 2.769 0 0
Signaling by Hippo R-HSA-2028269 1.703713e-03 2.769 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.795080e-03 2.746 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.946664e-03 2.711 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.946664e-03 2.711 0 0
Membrane Trafficking R-HSA-199991 1.821178e-03 2.740 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.841074e-03 2.735 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.981968e-03 2.703 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.028952e-03 2.693 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.277627e-03 2.643 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.331792e-03 2.632 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.235238e-03 2.651 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.290496e-03 2.640 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.331792e-03 2.632 0 0
Apoptosis R-HSA-109581 2.268823e-03 2.644 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.332553e-03 2.632 0 0
Regulation of CDH1 Function R-HSA-9764561 2.344182e-03 2.630 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.359026e-03 2.627 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.359026e-03 2.627 0 0
S Phase R-HSA-69242 2.524111e-03 2.598 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.674864e-03 2.573 0 0
Axon guidance R-HSA-422475 2.855242e-03 2.544 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.822766e-03 2.549 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.024805e-03 2.519 0 0
HIV Infection R-HSA-162906 3.053291e-03 2.515 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.395570e-03 2.469 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.399125e-03 2.469 0 0
Protein folding R-HSA-391251 3.241016e-03 2.489 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.291232e-03 2.483 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.395570e-03 2.469 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.123790e-03 2.505 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.291232e-03 2.483 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.541899e-03 2.451 0 0
Ribosome-associated quality control R-HSA-9948299 3.603618e-03 2.443 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.664607e-03 2.436 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.679658e-03 2.434 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.682616e-03 2.434 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.682616e-03 2.434 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.012541e-03 2.397 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.012541e-03 2.397 0 0
Selective autophagy R-HSA-9663891 4.082014e-03 2.389 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.210353e-03 2.376 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.517058e-03 2.345 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.895399e-03 2.310 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.906560e-03 2.309 0 0
Signaling by ROBO receptors R-HSA-376176 4.919968e-03 2.308 0 0
Formation of annular gap junctions R-HSA-196025 4.929059e-03 2.307 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.576298e-03 2.254 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.576298e-03 2.254 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.782123e-03 2.238 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.943619e-03 2.226 0 0
Gap junction trafficking R-HSA-190828 6.083437e-03 2.216 0 0
Nervous system development R-HSA-9675108 6.306818e-03 2.200 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.801575e-03 2.167 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.013263e-03 2.154 0 0
Gap junction degradation R-HSA-190873 7.038127e-03 2.153 0 0
ALK mutants bind TKIs R-HSA-9700645 7.038127e-03 2.153 0 0
Post NMDA receptor activation events R-HSA-438064 7.768876e-03 2.110 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.051418e-03 2.094 0 0
Interleukin-12 family signaling R-HSA-447115 7.768876e-03 2.110 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.286342e-03 2.082 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.371310e-03 2.077 0 0
Signal Transduction R-HSA-162582 8.638881e-03 2.064 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.702833e-03 2.060 0 0
Folding of actin by CCT/TriC R-HSA-390450 9.707679e-03 2.013 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.777455e-03 2.010 0 0
Programmed Cell Death R-HSA-5357801 9.975371e-03 2.001 0 0
Interleukin-12 signaling R-HSA-9020591 1.012438e-02 1.995 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.014849e-02 1.994 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.055462e-02 1.977 0 0
tRNA processing in the nucleus R-HSA-6784531 1.055462e-02 1.977 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.189826e-02 1.925 0 0
Gap junction trafficking and regulation R-HSA-157858 1.189826e-02 1.925 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.208601e-02 1.918 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.245951e-02 1.904 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.260889e-02 1.899 0 0
Adherens junctions interactions R-HSA-418990 1.312900e-02 1.882 0 0
Nucleotide Excision Repair R-HSA-5696398 1.326650e-02 1.877 0 0
Mitotic Prophase R-HSA-68875 1.480417e-02 1.830 0 0
Cell junction organization R-HSA-446728 1.374139e-02 1.862 0 0
Hedgehog 'off' state R-HSA-5610787 1.528622e-02 1.816 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.529079e-02 1.816 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.529079e-02 1.816 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.678350e-02 1.775 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.678350e-02 1.775 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.678350e-02 1.775 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.678350e-02 1.775 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.678350e-02 1.775 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.678350e-02 1.775 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.760027e-02 1.754 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.760027e-02 1.754 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.760027e-02 1.754 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.697654e-02 1.770 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.697654e-02 1.770 0 0
mRNA 3'-end processing R-HSA-72187 1.702107e-02 1.769 0 0
snRNP Assembly R-HSA-191859 1.670837e-02 1.777 0 0
Metabolism of non-coding RNA R-HSA-194441 1.670837e-02 1.777 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.623699e-02 1.789 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.762607e-02 1.754 0 0
Peptide chain elongation R-HSA-156902 1.713069e-02 1.766 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.670837e-02 1.777 0 0
Cell-Cell communication R-HSA-1500931 1.629515e-02 1.788 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.637703e-02 1.786 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.637703e-02 1.786 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.615406e-02 1.792 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.866040e-02 1.729 0 0
Eukaryotic Translation Termination R-HSA-72764 1.914587e-02 1.718 0 0
Host Interactions of HIV factors R-HSA-162909 1.981642e-02 1.703 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.061596e-02 1.686 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.143741e-02 1.669 0 0
Interferon Signaling R-HSA-913531 2.158084e-02 1.666 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.168415e-02 1.664 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.168415e-02 1.664 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.168415e-02 1.664 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.168415e-02 1.664 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.168415e-02 1.664 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.168415e-02 1.664 0 0
Notch-HLH transcription pathway R-HSA-350054 2.182617e-02 1.661 0 0
Homology Directed Repair R-HSA-5693538 2.284750e-02 1.641 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.294775e-02 1.639 0 0
Signaling by WNT R-HSA-195721 2.342611e-02 1.630 0 0
HCMV Early Events R-HSA-9609690 2.355784e-02 1.628 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.355784e-02 1.628 0 0
Signaling by NOTCH3 R-HSA-9012852 2.364872e-02 1.626 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.390342e-02 1.622 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.400586e-02 1.620 0 0
Intraflagellar transport R-HSA-5620924 2.429113e-02 1.615 0 0
RNA Polymerase I Transcription R-HSA-73864 2.490482e-02 1.604 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.716693e-02 1.566 0 0
Deadenylation of mRNA R-HSA-429947 3.007942e-02 1.522 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.835089e-02 1.547 0 0
Chromosome Maintenance R-HSA-73886 2.809458e-02 1.551 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.908574e-02 1.536 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.133197e-02 1.504 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.833976e-02 1.548 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.141335e-02 1.503 0 0
Unwinding of DNA R-HSA-176974 3.141335e-02 1.503 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.141335e-02 1.503 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.188334e-02 1.496 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.221617e-02 1.492 0 0
NrCAM interactions R-HSA-447038 3.221617e-02 1.492 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.240650e-02 1.489 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.276999e-02 1.485 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.276999e-02 1.485 0 0
2-LTR circle formation R-HSA-164843 4.016008e-02 1.396 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.058720e-02 1.392 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.058720e-02 1.392 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.020902e-02 1.396 0 0
Nucleosome assembly R-HSA-774815 3.859526e-02 1.413 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.859526e-02 1.413 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.041784e-02 1.393 0 0
PTEN Regulation R-HSA-6807070 3.735410e-02 1.428 0 0
DNA strand elongation R-HSA-69190 3.572982e-02 1.447 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.791727e-02 1.421 0 0
Signaling by NOTCH4 R-HSA-9013694 3.425198e-02 1.465 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.862972e-02 1.413 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.862972e-02 1.413 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.862972e-02 1.413 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.862972e-02 1.413 0 0
Protein ubiquitination R-HSA-8852135 3.724362e-02 1.429 0 0
Signaling by ALK R-HSA-201556 3.985505e-02 1.400 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.058720e-02 1.392 0 0
Signaling by NOTCH1 R-HSA-1980143 4.041784e-02 1.393 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.468557e-02 1.460 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.823688e-02 1.418 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.052606e-02 1.392 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.862972e-02 1.413 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.859526e-02 1.413 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.058720e-02 1.392 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.228188e-02 1.374 0 0
Cell-cell junction organization R-HSA-421270 4.370882e-02 1.359 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.452776e-02 1.351 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.482244e-02 1.349 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.482244e-02 1.349 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 4.482244e-02 1.349 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.601657e-02 1.337 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.601657e-02 1.337 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.601657e-02 1.337 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.601657e-02 1.337 0 0
DNA Repair R-HSA-73894 4.697248e-02 1.328 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.856751e-02 1.314 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.913071e-02 1.228 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.913071e-02 1.228 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.913071e-02 1.228 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.913071e-02 1.228 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.913071e-02 1.228 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.913071e-02 1.228 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.913071e-02 1.228 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.913071e-02 1.228 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.913071e-02 1.228 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.913071e-02 1.228 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.913071e-02 1.228 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.950763e-02 1.225 0 0
CREB phosphorylation R-HSA-199920 5.950763e-02 1.225 0 0
Signaling by APC mutants R-HSA-4839744 5.015326e-02 1.300 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.015326e-02 1.300 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.015326e-02 1.300 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.015326e-02 1.300 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.493819e-02 1.260 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.211494e-02 1.283 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.927890e-02 1.227 0 0
Viral mRNA Translation R-HSA-192823 6.066843e-02 1.217 0 0
MHC class II antigen presentation R-HSA-2132295 5.350852e-02 1.272 0 0
DARPP-32 events R-HSA-180024 5.917227e-02 1.228 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.961199e-02 1.304 0 0
Neurofascin interactions R-HSA-447043 5.950763e-02 1.225 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.917227e-02 1.228 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.132434e-02 1.212 0 0
Vesicle-mediated transport R-HSA-5653656 5.222362e-02 1.282 0 0
Gap junction assembly R-HSA-190861 5.135768e-02 1.289 0 0
Signaling by Hedgehog R-HSA-5358351 5.684616e-02 1.245 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.089543e-02 1.293 0 0
Cellular Senescence R-HSA-2559583 5.942333e-02 1.226 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.914999e-02 1.308 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.089543e-02 1.293 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.094979e-02 1.293 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.181629e-02 1.286 0 0
Selenocysteine synthesis R-HSA-2408557 5.339221e-02 1.273 0 0
Integration of provirus R-HSA-162592 6.138383e-02 1.212 0 0
Signaling by AXIN mutants R-HSA-4839735 6.138383e-02 1.212 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.138383e-02 1.212 0 0
Autophagy R-HSA-9612973 6.250329e-02 1.204 0 0
Signaling by VEGF R-HSA-194138 6.349007e-02 1.197 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.375804e-02 1.195 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.389701e-02 1.195 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.389701e-02 1.195 0 0
Calmodulin induced events R-HSA-111933 6.389701e-02 1.195 0 0
CaM pathway R-HSA-111997 6.389701e-02 1.195 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.403631e-02 1.194 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.455022e-02 1.190 0 0
Macroautophagy R-HSA-1632852 6.659846e-02 1.177 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.927472e-02 1.159 0 0
G2/M Checkpoints R-HSA-69481 7.081772e-02 1.150 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.082090e-02 1.150 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.382593e-02 1.132 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 7.382593e-02 1.132 0 0
Repression of WNT target genes R-HSA-4641265 7.382593e-02 1.132 0 0
Signaling by LTK R-HSA-9842663 7.382593e-02 1.132 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.508408e-02 1.124 0 0
Recycling of eIF2:GDP R-HSA-72731 7.614494e-02 1.118 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.766558e-02 1.110 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.790102e-02 1.108 0 0
DAG and IP3 signaling R-HSA-1489509 8.018170e-02 1.096 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.097686e-02 1.092 0 0
Meiotic synapsis R-HSA-1221632 8.097686e-02 1.092 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.097686e-02 1.092 0 0
Synthesis of DNA R-HSA-69239 8.175052e-02 1.088 0 0
G0 and Early G1 R-HSA-1538133 8.283808e-02 1.082 0 0
Signaling by WNT in cancer R-HSA-4791275 8.283808e-02 1.082 0 0
Glycolysis R-HSA-70171 8.408416e-02 1.075 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.479641e-02 1.072 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.312331e-02 1.031 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.312331e-02 1.031 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.678152e-02 1.062 0 0
MET interacts with TNS proteins R-HSA-8875513 8.678152e-02 1.062 0 0
Type I hemidesmosome assembly R-HSA-446107 9.457882e-02 1.024 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 8.743893e-02 1.058 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.021696e-01 0.991 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.905783e-02 1.050 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.012650e-01 0.995 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.012650e-01 0.995 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.012650e-01 0.995 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.012650e-01 0.995 0 0
Cristae formation R-HSA-8949613 1.081376e-01 0.966 0 0
Striated Muscle Contraction R-HSA-390522 1.012334e-01 0.995 0 0
Dual Incision in GG-NER R-HSA-5696400 1.111991e-01 0.954 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.743217e-02 1.058 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.743217e-02 1.058 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.743217e-02 1.058 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.743217e-02 1.058 0 0
MAP2K and MAPK activation R-HSA-5674135 1.120123e-01 0.951 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.715053e-02 1.013 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.012334e-01 0.995 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.029073e-01 0.988 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.177693e-02 1.037 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.715053e-02 1.013 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.111991e-01 0.954 0 0
Signaling by RAS mutants R-HSA-6802949 8.743217e-02 1.058 0 0
Formation of axial mesoderm R-HSA-9796292 8.743893e-02 1.058 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 9.457882e-02 1.024 0 0
GPER1 signaling R-HSA-9634597 1.030607e-01 0.987 0 0
Interleukin-7 signaling R-HSA-1266695 8.678967e-02 1.062 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.124676e-01 0.949 0 0
Ca2+ pathway R-HSA-4086398 1.055103e-01 0.977 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.384548e-02 1.028 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 9.177693e-02 1.037 0 0
Signaling by NOTCH R-HSA-157118 1.141506e-01 0.943 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 9.457882e-02 1.024 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.743893e-02 1.058 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.111991e-01 0.954 0 0
Gene expression (Transcription) R-HSA-74160 1.112536e-01 0.954 0 0
HDMs demethylate histones R-HSA-3214842 8.678967e-02 1.062 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.881448e-02 1.005 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.773098e-02 1.057 0 0
Inositol phosphate metabolism R-HSA-1483249 1.071163e-01 0.970 0 0
Semaphorin interactions R-HSA-373755 9.384548e-02 1.028 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.678967e-02 1.062 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.743893e-02 1.058 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.854682e-02 1.053 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.022272e-01 0.990 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.273878e-02 1.033 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.142586e-01 0.942 0 0
ARMS-mediated activation R-HSA-170984 1.146346e-01 0.941 0 0
HCMV Infection R-HSA-9609646 1.173769e-01 0.930 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.174429e-01 0.930 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.174429e-01 0.930 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.179540e-01 0.928 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.179540e-01 0.928 0 0
Ca-dependent events R-HSA-111996 1.215402e-01 0.915 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.230472e-01 0.910 0 0
IRE1alpha activates chaperones R-HSA-381070 1.257160e-01 0.901 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.264103e-01 0.898 0 0
Translation R-HSA-72766 1.265318e-01 0.898 0 0
UCH proteinases R-HSA-5689603 1.271588e-01 0.896 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.280041e-01 0.893 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.302680e-01 0.885 0 0
Defective pyroptosis R-HSA-9710421 1.314812e-01 0.881 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.318172e-01 0.880 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.319179e-01 0.880 0 0
Prolonged ERK activation events R-HSA-169893 1.347197e-01 0.871 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.351061e-01 0.869 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.361262e-01 0.866 0 0
DNA replication initiation R-HSA-68952 1.361262e-01 0.866 0 0
Signal attenuation R-HSA-74749 1.361262e-01 0.866 0 0
Regulation of CDH11 function R-HSA-9762292 1.361262e-01 0.866 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.361262e-01 0.866 0 0
Signaling by Leptin R-HSA-2586552 1.361262e-01 0.866 0 0
ESR-mediated signaling R-HSA-8939211 1.404093e-01 0.853 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.415622e-01 0.849 0 0
RMTs methylate histone arginines R-HSA-3214858 1.418248e-01 0.848 0 0
Activation of the pre-replicative complex R-HSA-68962 1.446665e-01 0.840 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.485029e-01 0.828 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.485192e-01 0.828 0 0
Smooth Muscle Contraction R-HSA-445355 1.485192e-01 0.828 0 0
IRS activation R-HSA-74713 1.503151e-01 0.823 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.503151e-01 0.823 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.503151e-01 0.823 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.503151e-01 0.823 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.510913e-01 0.821 0 0
Disorders of Developmental Biology R-HSA-9675151 1.523875e-01 0.817 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.523875e-01 0.817 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.523875e-01 0.817 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.523875e-01 0.817 0 0
Mitochondrial protein import R-HSA-1268020 1.534150e-01 0.814 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.558993e-01 0.807 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.588626e-01 0.799 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.775797e-01 0.751 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.775797e-01 0.751 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.775797e-01 0.751 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.847211e-01 0.733 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.847211e-01 0.733 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.847211e-01 0.733 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.200907e-01 0.657 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 1.826526e-01 0.738 0 0
Activation of RAC1 R-HSA-428540 1.826526e-01 0.738 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.826526e-01 0.738 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.073086e-01 0.683 0 0
Pervasive developmental disorders R-HSA-9005895 2.073086e-01 0.683 0 0
Disorders of Nervous System Development R-HSA-9697154 2.073086e-01 0.683 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.073086e-01 0.683 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.073086e-01 0.683 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.326496e-01 0.633 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.896641e-01 0.722 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.303564e-01 0.638 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.238204e-01 0.650 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.809132e-01 0.743 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.158565e-01 0.666 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.691049e-01 0.772 0 0
HDACs deacetylate histones R-HSA-3214815 1.691049e-01 0.772 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 2.074779e-01 0.683 0 0
HIV Transcription Initiation R-HSA-167161 2.074779e-01 0.683 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 2.074779e-01 0.683 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.798718e-01 0.745 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.353964e-01 0.628 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.373330e-01 0.625 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.949785e-01 0.710 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.262174e-01 0.645 0 0
Interleukin-15 signaling R-HSA-8983432 2.073086e-01 0.683 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.809132e-01 0.743 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.809132e-01 0.743 0 0
Formation of definitive endoderm R-HSA-9823730 2.303564e-01 0.638 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.158565e-01 0.666 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.826526e-01 0.738 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.682597e-01 0.774 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.661114e-01 0.780 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.940136e-01 0.712 0 0
DNA Double Strand Break Response R-HSA-5693606 2.041515e-01 0.690 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.376648e-01 0.624 0 0
Meiosis R-HSA-1500620 2.052969e-01 0.688 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.303564e-01 0.638 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.809132e-01 0.743 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.826526e-01 0.738 0 0
RAF activation R-HSA-5673000 2.158565e-01 0.666 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.033362e-01 0.692 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.661114e-01 0.780 0 0
Nuclear RNA decay R-HSA-9930044 1.860185e-01 0.730 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.118520e-01 0.674 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.200907e-01 0.657 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.826526e-01 0.738 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.073086e-01 0.683 0 0
Extension of Telomeres R-HSA-180786 2.139135e-01 0.670 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.860185e-01 0.730 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.313524e-01 0.636 0 0
DNA Replication R-HSA-69306 2.398972e-01 0.620 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.144444e-01 0.669 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.099475e-01 0.678 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.373330e-01 0.625 0 0
Signalling to ERKs R-HSA-187687 2.313524e-01 0.636 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.785207e-01 0.748 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.200907e-01 0.657 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.940136e-01 0.712 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.632731e-01 0.787 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.940136e-01 0.712 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.763534e-01 0.754 0 0
Opioid Signalling R-HSA-111885 1.632731e-01 0.787 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 1.847211e-01 0.733 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.900898e-01 0.721 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.212809e-01 0.655 0 0
PLC beta mediated events R-HSA-112043 2.379136e-01 0.624 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.763534e-01 0.754 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.413701e-01 0.617 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.888052e-01 0.724 0 0
Integration of energy metabolism R-HSA-163685 1.763534e-01 0.754 0 0
Degradation of CDH1 R-HSA-9766229 1.991083e-01 0.701 0 0
Nephrin family interactions R-HSA-373753 2.303564e-01 0.638 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.787016e-01 0.748 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.956023e-01 0.709 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.754905e-01 0.756 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.860185e-01 0.730 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.200907e-01 0.657 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 2.099475e-01 0.678 0 0
G1/S Transition R-HSA-69206 2.165731e-01 0.664 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.313524e-01 0.636 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.375824e-01 0.624 0 0
Viral Infection Pathways R-HSA-9824446 2.070406e-01 0.684 0 0
Glucose metabolism R-HSA-70326 2.186099e-01 0.660 0 0
Maturation of nucleoprotein R-HSA-9683610 2.326496e-01 0.633 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.630132e-01 0.788 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.847211e-01 0.733 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.303564e-01 0.638 0 0
Gene Silencing by RNA R-HSA-211000 1.949817e-01 0.710 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.150695e-01 0.667 0 0
Selenoamino acid metabolism R-HSA-2408522 1.855432e-01 0.732 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.417023e-01 0.617 0 0
Co-inhibition by PD-1 R-HSA-389948 2.442238e-01 0.612 0 0
Diseases of programmed cell death R-HSA-9645723 2.455341e-01 0.610 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.541752e-01 0.595 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.541752e-01 0.595 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.541752e-01 0.595 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.541752e-01 0.595 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 2.541752e-01 0.595 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 2.541752e-01 0.595 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.541752e-01 0.595 0 0
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) R-HSA-5619048 2.541752e-01 0.595 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.236412e-01 0.490 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.236412e-01 0.490 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.559464e-01 0.592 0 0
Disinhibition of SNARE formation R-HSA-114516 2.559464e-01 0.592 0 0
SOS-mediated signalling R-HSA-112412 2.559464e-01 0.592 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.559464e-01 0.592 0 0
MET activates STAT3 R-HSA-8875791 3.866409e-01 0.413 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.866409e-01 0.413 0 0
Axonal growth stimulation R-HSA-209563 3.866409e-01 0.413 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.866409e-01 0.413 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.866409e-01 0.413 0 0
Signalling to STAT3 R-HSA-198745 3.866409e-01 0.413 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.866409e-01 0.413 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 3.866409e-01 0.413 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.918912e-01 0.535 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.918912e-01 0.535 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.918912e-01 0.535 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.918912e-01 0.535 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.585036e-01 0.588 0 0
Lipophagy R-HSA-9613354 3.275978e-01 0.485 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.275978e-01 0.485 0 0
Calcineurin activates NFAT R-HSA-2025928 3.275978e-01 0.485 0 0
Regulation of gap junction activity R-HSA-191650 4.437758e-01 0.353 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.437758e-01 0.353 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.437758e-01 0.353 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.437758e-01 0.353 0 0
Signaling by LRP5 mutants R-HSA-5339717 4.437758e-01 0.353 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.847089e-01 0.546 0 0
Lagging Strand Synthesis R-HSA-69186 2.512271e-01 0.600 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.627990e-01 0.440 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.111149e-01 0.507 0 0
Phosphorylation of the APC/C R-HSA-176412 3.111149e-01 0.507 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.111149e-01 0.507 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.724715e-01 0.565 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.724715e-01 0.565 0 0
Late endosomal microautophagy R-HSA-9615710 2.596292e-01 0.586 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.596292e-01 0.586 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.375834e-01 0.472 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.972793e-01 0.401 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.972793e-01 0.401 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.972793e-01 0.401 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.780163e-01 0.556 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.157422e-01 0.501 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.157422e-01 0.501 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.639880e-01 0.439 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.639880e-01 0.439 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.639880e-01 0.439 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.308678e-01 0.366 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.308678e-01 0.366 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.644568e-01 0.578 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.963153e-01 0.528 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.793462e-01 0.554 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.944375e-01 0.531 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.944375e-01 0.531 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.917020e-01 0.535 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.161627e-01 0.381 0 0
Leading Strand Synthesis R-HSA-69109 4.634315e-01 0.334 0 0
Polymerase switching R-HSA-69091 4.634315e-01 0.334 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.471103e-01 0.460 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.642397e-01 0.439 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 4.417408e-01 0.355 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.719427e-01 0.430 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.719427e-01 0.430 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.719427e-01 0.430 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.550228e-01 0.450 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.668705e-01 0.331 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.668705e-01 0.331 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.668705e-01 0.331 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.876611e-01 0.412 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.876611e-01 0.412 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.328258e-01 0.364 0 0
Dual incision in TC-NER R-HSA-6782135 4.659268e-01 0.332 0 0
Neutrophil degranulation R-HSA-6798695 3.329624e-01 0.478 0 0
Transcription of the HIV genome R-HSA-167172 3.280776e-01 0.484 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.475239e-01 0.606 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.372679e-01 0.359 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.376065e-01 0.472 0 0
Integrin signaling R-HSA-354192 3.344615e-01 0.476 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.644568e-01 0.578 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.376106e-01 0.472 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.491513e-01 0.604 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.644568e-01 0.578 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.375834e-01 0.472 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 3.157422e-01 0.501 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.376065e-01 0.472 0 0
ER-Phagosome pathway R-HSA-1236974 4.886615e-01 0.311 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.248911e-01 0.372 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.917020e-01 0.535 0 0
Interleukin-21 signaling R-HSA-9020958 3.275978e-01 0.485 0 0
PI3K/AKT activation R-HSA-198203 3.627990e-01 0.440 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.972793e-01 0.401 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.297986e-01 0.367 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.686039e-01 0.433 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.686039e-01 0.433 0 0
Interleukin-9 signaling R-HSA-8985947 2.918912e-01 0.535 0 0
Telomere Maintenance R-HSA-157579 3.677774e-01 0.434 0 0
Generation of second messenger molecules R-HSA-202433 4.858129e-01 0.314 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.437758e-01 0.353 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.157422e-01 0.501 0 0
NF-kB is activated and signals survival R-HSA-209560 4.308678e-01 0.366 0 0
PKA activation R-HSA-163615 3.902151e-01 0.409 0 0
Trafficking of AMPA receptors R-HSA-399719 4.884548e-01 0.311 0 0
Interleukin-2 signaling R-HSA-9020558 3.972793e-01 0.401 0 0
Ephrin signaling R-HSA-3928664 3.902151e-01 0.409 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.161627e-01 0.381 0 0
Adipogenesis R-HSA-9843745 3.672327e-01 0.435 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.512271e-01 0.600 0 0
Long-term potentiation R-HSA-9620244 3.595220e-01 0.444 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.814090e-01 0.419 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.157338e-01 0.381 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.485477e-01 0.348 0 0
Proteasome assembly R-HSA-9907900 3.985845e-01 0.399 0 0
Formation of the posterior neural plate R-HSA-9832991 3.972793e-01 0.401 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.639880e-01 0.439 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.308678e-01 0.366 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.502583e-01 0.602 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.157338e-01 0.381 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.675537e-01 0.330 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.013336e-01 0.521 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.106189e-01 0.508 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.535310e-01 0.452 0 0
Signal transduction by L1 R-HSA-445144 4.417408e-01 0.355 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.275978e-01 0.485 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.471103e-01 0.460 0 0
Inhibition of nitric oxide production R-HSA-9636249 3.866409e-01 0.413 0 0
FasL/ CD95L signaling R-HSA-75157 3.866409e-01 0.413 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.847089e-01 0.546 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.154852e-01 0.501 0 0
HATs acetylate histones R-HSA-3214847 2.840420e-01 0.547 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.677774e-01 0.434 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.144468e-01 0.383 0 0
Adrenoceptors R-HSA-390696 2.918912e-01 0.535 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.918912e-01 0.535 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.724715e-01 0.565 0 0
ERK/MAPK targets R-HSA-198753 4.668705e-01 0.331 0 0
Cellular response to starvation R-HSA-9711097 2.795830e-01 0.553 0 0
Hedgehog 'on' state R-HSA-5632684 2.491513e-01 0.604 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.634315e-01 0.334 0 0
Cellular response to hypoxia R-HSA-1234174 4.215041e-01 0.375 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.938632e-01 0.532 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.376065e-01 0.472 0 0
Platelet degranulation R-HSA-114608 3.183243e-01 0.497 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.822341e-01 0.418 0 0
TCR signaling R-HSA-202403 4.154226e-01 0.382 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.902151e-01 0.409 0 0
Cellular response to chemical stress R-HSA-9711123 4.613997e-01 0.336 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.475239e-01 0.606 0 0
MAPK family signaling cascades R-HSA-5683057 3.208842e-01 0.494 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.541752e-01 0.595 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.541752e-01 0.595 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.236412e-01 0.490 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.559464e-01 0.592 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 2.559464e-01 0.592 0 0
Type II Na+/Pi cotransporters R-HSA-427589 3.866409e-01 0.413 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.918912e-01 0.535 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.275978e-01 0.485 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.275978e-01 0.485 0 0
Alanine metabolism R-HSA-8964540 4.437758e-01 0.353 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.437758e-01 0.353 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.724715e-01 0.565 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.596292e-01 0.586 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.972793e-01 0.401 0 0
PKA activation in glucagon signalling R-HSA-164378 3.902151e-01 0.409 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.131119e-01 0.504 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.728464e-01 0.564 0 0
Signaling by NOTCH2 R-HSA-1980145 3.726450e-01 0.429 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.248911e-01 0.372 0 0
Orc1 removal from chromatin R-HSA-68949 3.719427e-01 0.430 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.033902e-01 0.394 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.673297e-01 0.330 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.884548e-01 0.311 0 0
NGF-stimulated transcription R-HSA-9031628 4.667207e-01 0.331 0 0
EPH-Ephrin signaling R-HSA-2682334 2.994526e-01 0.524 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.471103e-01 0.460 0 0
G alpha (12/13) signalling events R-HSA-416482 4.641044e-01 0.333 0 0
Biotin transport and metabolism R-HSA-196780 2.847089e-01 0.546 0 0
EGFR downregulation R-HSA-182971 4.884548e-01 0.311 0 0
Death Receptor Signaling R-HSA-73887 3.274952e-01 0.485 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.298637e-01 0.482 0 0
RNA Polymerase II Transcription R-HSA-73857 4.675531e-01 0.330 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.710608e-01 0.431 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.275978e-01 0.485 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.275978e-01 0.485 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.344615e-01 0.476 0 0
Rap1 signalling R-HSA-392517 4.161627e-01 0.381 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.777367e-01 0.423 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.297986e-01 0.367 0 0
Deubiquitination R-HSA-5688426 2.970821e-01 0.527 0 0
Co-stimulation by CD28 R-HSA-389356 4.667207e-01 0.331 0 0
PCP/CE pathway R-HSA-4086400 4.641044e-01 0.333 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.631882e-01 0.440 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.179042e-01 0.379 0 0
CHL1 interactions R-HSA-447041 2.559464e-01 0.592 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.275978e-01 0.485 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.847089e-01 0.546 0 0
Interleukin-27 signaling R-HSA-9020956 3.627990e-01 0.440 0 0
Heme signaling R-HSA-9707616 2.502583e-01 0.602 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.157338e-01 0.381 0 0
G-protein mediated events R-HSA-112040 3.147490e-01 0.502 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.300558e-01 0.481 0 0
Signaling by NTRKs R-HSA-166520 2.758628e-01 0.559 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.914836e-01 0.308 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.541752e-01 0.595 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 3.275978e-01 0.485 0 0
NADE modulates death signalling R-HSA-205025 4.437758e-01 0.353 0 0
Josephin domain DUBs R-HSA-5689877 3.627990e-01 0.440 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.627990e-01 0.440 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.308678e-01 0.366 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.902151e-01 0.409 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.902151e-01 0.409 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.535310e-01 0.452 0 0
Signaling by ERBB2 R-HSA-1227986 3.486946e-01 0.458 0 0
Signaling by EGFR R-HSA-177929 4.347815e-01 0.362 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.940041e-01 0.532 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.914836e-01 0.308 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.231622e-01 0.491 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.963153e-01 0.528 0 0
Protein hydroxylation R-HSA-9629569 4.417408e-01 0.355 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.797032e-01 0.553 0 0
NRAGE signals death through JNK R-HSA-193648 2.917020e-01 0.535 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.675537e-01 0.330 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.609107e-01 0.584 0 0
Activation of BH3-only proteins R-HSA-114452 4.675537e-01 0.330 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.236412e-01 0.490 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.559464e-01 0.592 0 0
Sodium/Proton exchangers R-HSA-425986 2.918912e-01 0.535 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.437758e-01 0.353 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.627990e-01 0.440 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.111149e-01 0.507 0 0
Downstream signal transduction R-HSA-186763 2.966528e-01 0.528 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.550228e-01 0.450 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.914836e-01 0.308 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.512271e-01 0.600 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.471839e-01 0.607 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.550228e-01 0.450 0 0
tRNA processing R-HSA-72306 3.072712e-01 0.512 0 0
Diseases of DNA repair R-HSA-9675135 2.793462e-01 0.554 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.131119e-01 0.504 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.559464e-01 0.592 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.275978e-01 0.485 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.847089e-01 0.546 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.963153e-01 0.528 0 0
Basigin interactions R-HSA-210991 4.668705e-01 0.331 0 0
Potential therapeutics for SARS R-HSA-9679191 4.759783e-01 0.322 0 0
Interleukin-35 Signalling R-HSA-8984722 4.634315e-01 0.334 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.971901e-01 0.527 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.111149e-01 0.507 0 0
Sensory processing of sound R-HSA-9659379 3.473553e-01 0.459 0 0
Maturation of nucleoprotein R-HSA-9694631 4.161627e-01 0.381 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.675537e-01 0.330 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.949860e-01 0.403 0 0
SARS-CoV Infections R-HSA-9679506 4.808774e-01 0.318 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.706191e-01 0.568 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.673297e-01 0.330 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.161627e-01 0.381 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.936894e-01 0.307 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.948700e-01 0.306 0 0
Frs2-mediated activation R-HSA-170968 4.948700e-01 0.306 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.948700e-01 0.306 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.948700e-01 0.306 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.955916e-01 0.305 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.955916e-01 0.305 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.955916e-01 0.305 0 0
Defective F9 activation R-HSA-9673221 4.955916e-01 0.305 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.955916e-01 0.305 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.955916e-01 0.305 0 0
PTK6 Activates STAT3 R-HSA-8849474 4.955916e-01 0.305 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.955916e-01 0.305 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.955916e-01 0.305 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.955916e-01 0.305 0 0
Activation of C3 and C5 R-HSA-174577 4.955916e-01 0.305 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.955916e-01 0.305 0 0
Reelin signalling pathway R-HSA-8866376 4.955916e-01 0.305 0 0
Inositol transporters R-HSA-429593 4.955916e-01 0.305 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.955916e-01 0.305 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.955916e-01 0.305 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.955916e-01 0.305 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.974325e-01 0.303 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.000506e-01 0.301 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.040645e-01 0.298 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.040645e-01 0.298 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.090112e-01 0.293 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.090112e-01 0.293 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.090112e-01 0.293 0 0
FOXO-mediated transcription R-HSA-9614085 5.105131e-01 0.292 0 0
mTORC1-mediated signalling R-HSA-166208 5.155221e-01 0.288 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.155221e-01 0.288 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 5.164030e-01 0.287 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.164425e-01 0.287 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.164425e-01 0.287 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.220554e-01 0.282 0 0
Removal of the Flap Intermediate R-HSA-69166 5.251103e-01 0.280 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.251103e-01 0.280 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.251103e-01 0.280 0 0
Malate-aspartate shuttle R-HSA-9856872 5.251103e-01 0.280 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.268013e-01 0.278 0 0
G-protein beta:gamma signalling R-HSA-397795 5.291853e-01 0.276 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.291853e-01 0.276 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.291853e-01 0.276 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.291853e-01 0.276 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.291853e-01 0.276 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.291853e-01 0.276 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.389370e-01 0.268 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.389370e-01 0.268 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.389370e-01 0.268 0 0
Growth hormone receptor signaling R-HSA-982772 5.389370e-01 0.268 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.397591e-01 0.268 0 0
MTOR signalling R-HSA-165159 5.397591e-01 0.268 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.397591e-01 0.268 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.398488e-01 0.268 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.425833e-01 0.266 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.425833e-01 0.266 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.425833e-01 0.266 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.425833e-01 0.266 0 0
Signaling by MAPK mutants R-HSA-9652817 5.425833e-01 0.266 0 0
Terminal pathway of complement R-HSA-166665 5.425833e-01 0.266 0 0
TRAIL signaling R-HSA-75158 5.425833e-01 0.266 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.425833e-01 0.266 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.425833e-01 0.266 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.425833e-01 0.266 0 0
Relaxin receptors R-HSA-444821 5.425833e-01 0.266 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.425833e-01 0.266 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.485722e-01 0.261 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.489442e-01 0.260 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.513643e-01 0.259 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.541029e-01 0.256 0 0
Erythropoietin activates RAS R-HSA-9027284 5.541029e-01 0.256 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.541029e-01 0.256 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.541029e-01 0.256 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.541029e-01 0.256 0 0
p75NTR signals via NF-kB R-HSA-193639 5.541029e-01 0.256 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.541029e-01 0.256 0 0
Protein methylation R-HSA-8876725 5.541029e-01 0.256 0 0
Formation of the anterior neural plate R-HSA-9823739 5.541029e-01 0.256 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.541029e-01 0.256 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.616883e-01 0.251 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.616883e-01 0.251 0 0
Complex III assembly R-HSA-9865881 5.616883e-01 0.251 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.616883e-01 0.251 0 0
Neurodegenerative Diseases R-HSA-8863678 5.616883e-01 0.251 0 0
Reproduction R-HSA-1474165 5.645650e-01 0.248 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.682591e-01 0.245 0 0
Mitophagy R-HSA-5205647 5.682591e-01 0.245 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.682591e-01 0.245 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.682591e-01 0.245 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.682591e-01 0.245 0 0
Signaling by TGFB family members R-HSA-9006936 5.708822e-01 0.243 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.750516e-01 0.240 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.798161e-01 0.237 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.818177e-01 0.235 0 0
Activation of SMO R-HSA-5635838 5.818177e-01 0.235 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.818177e-01 0.235 0 0
Virus Assembly and Release R-HSA-168268 5.818177e-01 0.235 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.837439e-01 0.234 0 0
TGFBR3 expression R-HSA-9839394 5.837439e-01 0.234 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.837439e-01 0.234 0 0
Circadian clock R-HSA-9909396 5.847446e-01 0.233 0 0
Signaling by LTK in cancer R-HSA-9842640 5.851996e-01 0.233 0 0
Chylomicron clearance R-HSA-8964026 5.851996e-01 0.233 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.851996e-01 0.233 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.851996e-01 0.233 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.851996e-01 0.233 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.851996e-01 0.233 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.871053e-01 0.231 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.871053e-01 0.231 0 0
Regulation of Apoptosis R-HSA-169911 5.871053e-01 0.231 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.888575e-01 0.230 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.896589e-01 0.229 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.909203e-01 0.228 0 0
Somitogenesis R-HSA-9824272 5.909203e-01 0.228 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.909203e-01 0.228 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.909203e-01 0.228 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.948576e-01 0.226 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.961388e-01 0.225 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.050790e-01 0.218 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.050790e-01 0.218 0 0
Myogenesis R-HSA-525793 6.050790e-01 0.218 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.050790e-01 0.218 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.054620e-01 0.218 0 0
RNA Polymerase III Transcription R-HSA-74158 6.054620e-01 0.218 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.054620e-01 0.218 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.072607e-01 0.217 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.072607e-01 0.217 1 1
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.082413e-01 0.216 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.082413e-01 0.216 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.082413e-01 0.216 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.082413e-01 0.216 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.082413e-01 0.216 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.082413e-01 0.216 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.082413e-01 0.216 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.082413e-01 0.216 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.122520e-01 0.213 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.124940e-01 0.213 0 0
Regulation of insulin secretion R-HSA-422356 6.214724e-01 0.207 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.232186e-01 0.205 0 0
Degradation of DVL R-HSA-4641258 6.233122e-01 0.205 0 0
Degradation of AXIN R-HSA-4641257 6.233122e-01 0.205 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.233122e-01 0.205 0 0
Regulation of PTEN localization R-HSA-8948747 6.238477e-01 0.205 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.238477e-01 0.205 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.238477e-01 0.205 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.238477e-01 0.205 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.238477e-01 0.205 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.238477e-01 0.205 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.238477e-01 0.205 0 0
PTK6 Expression R-HSA-8849473 6.238477e-01 0.205 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.238477e-01 0.205 0 0
Opsins R-HSA-419771 6.238477e-01 0.205 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.238477e-01 0.205 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.238477e-01 0.205 0 0
VLDL clearance R-HSA-8964046 6.238477e-01 0.205 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.242667e-01 0.205 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.256753e-01 0.204 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.256753e-01 0.204 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.256753e-01 0.204 0 0
Signaling by Interleukins R-HSA-449147 6.262787e-01 0.203 0 0
Mitochondrial biogenesis R-HSA-1592230 6.274931e-01 0.202 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.333737e-01 0.198 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.333737e-01 0.198 0 0
Specification of primordial germ cells R-HSA-9827857 6.333737e-01 0.198 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 6.406423e-01 0.193 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.406423e-01 0.193 0 0
Telomere Extension By Telomerase R-HSA-171319 6.455208e-01 0.190 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.455208e-01 0.190 0 0
DNA Damage Bypass R-HSA-73893 6.539409e-01 0.184 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.572259e-01 0.182 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.572259e-01 0.182 0 0
Polo-like kinase mediated events R-HSA-156711 6.572259e-01 0.182 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.572259e-01 0.182 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.572259e-01 0.182 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.572259e-01 0.182 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.572259e-01 0.182 0 0
Platelet sensitization by LDL R-HSA-432142 6.572259e-01 0.182 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.572259e-01 0.182 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.574418e-01 0.182 0 0
Stabilization of p53 R-HSA-69541 6.574418e-01 0.182 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.588970e-01 0.181 0 0
Regulation by c-FLIP R-HSA-3371378 6.588970e-01 0.181 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.588970e-01 0.181 0 0
Dimerization of procaspase-8 R-HSA-69416 6.588970e-01 0.181 0 0
MET receptor recycling R-HSA-8875656 6.588970e-01 0.181 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.588970e-01 0.181 0 0
Interleukin-23 signaling R-HSA-9020933 6.588970e-01 0.181 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.588970e-01 0.181 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.588970e-01 0.181 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.588970e-01 0.181 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.588970e-01 0.181 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.588970e-01 0.181 0 0
Gastrulation R-HSA-9758941 6.630193e-01 0.178 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.642906e-01 0.178 0 0
DNA methylation R-HSA-5334118 6.646085e-01 0.177 0 0
mRNA Capping R-HSA-72086 6.646085e-01 0.177 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.646085e-01 0.177 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.646085e-01 0.177 0 0
Glucagon-type ligand receptors R-HSA-420092 6.646085e-01 0.177 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 6.646853e-01 0.177 0 0
Aquaporin-mediated transport R-HSA-445717 6.659856e-01 0.177 0 0
Azathioprine ADME R-HSA-9748787 6.686870e-01 0.175 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.708763e-01 0.173 0 0
Interleukin-2 family signaling R-HSA-451927 6.737033e-01 0.172 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.737033e-01 0.172 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.759067e-01 0.170 0 0
Signaling by PDGF R-HSA-186797 6.792217e-01 0.168 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.798184e-01 0.168 0 0
Translesion Synthesis by POLH R-HSA-110320 6.798184e-01 0.168 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.798184e-01 0.168 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.798184e-01 0.168 0 0
The NLRP3 inflammasome R-HSA-844456 6.798184e-01 0.168 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.798184e-01 0.168 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.829365e-01 0.166 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.829365e-01 0.166 0 0
Interleukin-37 signaling R-HSA-9008059 6.829365e-01 0.166 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.830143e-01 0.166 0 0
The phototransduction cascade R-HSA-2514856 6.830143e-01 0.166 1 0
Protein-protein interactions at synapses R-HSA-6794362 6.872733e-01 0.163 0 0
Signaling by ERBB4 R-HSA-1236394 6.890989e-01 0.162 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.894220e-01 0.162 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.894220e-01 0.162 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 6.906823e-01 0.161 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.906823e-01 0.161 0 0
CASP8 activity is inhibited R-HSA-5218900 6.906823e-01 0.161 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.906823e-01 0.161 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.906823e-01 0.161 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.906823e-01 0.161 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.906823e-01 0.161 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.906823e-01 0.161 0 0
Neurexins and neuroligins R-HSA-6794361 6.969183e-01 0.157 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.983865e-01 0.156 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.983865e-01 0.156 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.005070e-01 0.155 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.011788e-01 0.154 0 0
Negative regulation of MET activity R-HSA-6807004 7.011788e-01 0.154 0 0
Creatine metabolism R-HSA-71288 7.011788e-01 0.154 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.045959e-01 0.152 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.045959e-01 0.152 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.045959e-01 0.152 0 0
Translation of Structural Proteins R-HSA-9683701 7.045959e-01 0.152 0 0
IGF1R signaling cascade R-HSA-2428924 7.046569e-01 0.152 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.057868e-01 0.151 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.168497e-01 0.145 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.172444e-01 0.144 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.195074e-01 0.143 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.195074e-01 0.143 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.195074e-01 0.143 0 0
Binding and entry of HIV virion R-HSA-173107 7.195074e-01 0.143 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.195074e-01 0.143 0 0
Pexophagy R-HSA-9664873 7.195074e-01 0.143 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.195074e-01 0.143 0 0
Maturation of spike protein R-HSA-9683686 7.195074e-01 0.143 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.195074e-01 0.143 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.195074e-01 0.143 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.213405e-01 0.142 0 0
G-protein activation R-HSA-202040 7.213405e-01 0.142 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.213405e-01 0.142 0 0
Signalling to RAS R-HSA-167044 7.213405e-01 0.142 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.213405e-01 0.142 0 0
Hemostasis R-HSA-109582 7.219243e-01 0.142 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.333115e-01 0.135 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.333115e-01 0.135 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.341289e-01 0.134 0 0
G alpha (z) signalling events R-HSA-418597 7.360698e-01 0.133 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.367443e-01 0.133 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.403413e-01 0.131 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.403413e-01 0.131 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.403413e-01 0.131 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.403413e-01 0.131 0 0
Ribavirin ADME R-HSA-9755088 7.403413e-01 0.131 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.456479e-01 0.127 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.456479e-01 0.127 0 0
vRNA Synthesis R-HSA-192814 7.456479e-01 0.127 0 0
Conjugation of benzoate with glycine R-HSA-177135 7.456479e-01 0.127 0 0
vRNP Assembly R-HSA-192905 7.456479e-01 0.127 0 0
Bicarbonate transporters R-HSA-425381 7.456479e-01 0.127 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.456479e-01 0.127 0 0
Chylomicron assembly R-HSA-8963888 7.456479e-01 0.127 0 0
Suppression of apoptosis R-HSA-9635465 7.456479e-01 0.127 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.456479e-01 0.127 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.468595e-01 0.127 0 0
TNF signaling R-HSA-75893 7.482671e-01 0.126 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.482671e-01 0.126 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.487484e-01 0.126 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.494024e-01 0.125 0 0
Base Excision Repair R-HSA-73884 7.500655e-01 0.125 0 0
Downstream TCR signaling R-HSA-202424 7.500655e-01 0.125 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.519825e-01 0.124 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.519825e-01 0.124 0 0
Signaling by MET R-HSA-6806834 7.552288e-01 0.122 0 0
Generic Transcription Pathway R-HSA-212436 7.564627e-01 0.121 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.582225e-01 0.120 0 0
FGFR2 alternative splicing R-HSA-6803529 7.582225e-01 0.120 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.582225e-01 0.120 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.582225e-01 0.120 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.582225e-01 0.120 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.582225e-01 0.120 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.582225e-01 0.120 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.598749e-01 0.119 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.633782e-01 0.117 0 0
eNOS activation R-HSA-203615 7.633782e-01 0.117 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.633782e-01 0.117 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.651998e-01 0.116 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.693537e-01 0.114 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.693537e-01 0.114 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.693537e-01 0.114 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.693537e-01 0.114 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.693537e-01 0.114 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 7.693537e-01 0.114 0 0
ERKs are inactivated R-HSA-202670 7.693537e-01 0.114 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.693537e-01 0.114 0 0
Signaling by TGFBR3 R-HSA-9839373 7.723648e-01 0.112 0 0
COPII-mediated vesicle transport R-HSA-204005 7.725323e-01 0.112 0 0
Interleukin-20 family signaling R-HSA-8854691 7.750276e-01 0.111 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.750276e-01 0.111 0 0
Transferrin endocytosis and recycling R-HSA-917977 7.773081e-01 0.109 0 0
PERK regulates gene expression R-HSA-381042 7.773081e-01 0.109 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.843378e-01 0.105 0 0
Developmental Cell Lineages R-HSA-9734767 7.845155e-01 0.105 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.905562e-01 0.102 0 0
RET signaling R-HSA-8853659 7.905562e-01 0.102 0 0
G1/S-Specific Transcription R-HSA-69205 7.905562e-01 0.102 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.908020e-01 0.102 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.908020e-01 0.102 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.908020e-01 0.102 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.908020e-01 0.102 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.908020e-01 0.102 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.908513e-01 0.102 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.908513e-01 0.102 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.908513e-01 0.102 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.908513e-01 0.102 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.908513e-01 0.102 0 0
Conjugation of salicylate with glycine R-HSA-177128 7.908513e-01 0.102 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.908513e-01 0.102 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.908513e-01 0.102 0 0
MET activates RAS signaling R-HSA-8851805 7.908513e-01 0.102 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.908513e-01 0.102 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.908513e-01 0.102 0 0
Regulation of IFNG signaling R-HSA-877312 7.908513e-01 0.102 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.908513e-01 0.102 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.908513e-01 0.102 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 7.908513e-01 0.102 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.908513e-01 0.102 0 0
OAS antiviral response R-HSA-8983711 7.908513e-01 0.102 0 0
tRNA Aminoacylation R-HSA-379724 7.928653e-01 0.101 0 0
Gluconeogenesis R-HSA-70263 7.958037e-01 0.099 0 0
Metal ion SLC transporters R-HSA-425410 7.958037e-01 0.099 0 0
Developmental Biology R-HSA-1266738 7.976199e-01 0.098 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.976647e-01 0.098 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.976647e-01 0.098 0 0
MAP kinase activation R-HSA-450294 8.029925e-01 0.095 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.029925e-01 0.095 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.031419e-01 0.095 0 0
G protein gated Potassium channels R-HSA-1296059 8.055916e-01 0.094 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.055916e-01 0.094 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.055916e-01 0.094 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.055916e-01 0.094 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.067732e-01 0.093 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.067732e-01 0.093 0 0
HCMV Late Events R-HSA-9610379 8.074279e-01 0.093 0 0
Muscle contraction R-HSA-397014 8.097322e-01 0.092 0 0
Chylomicron remodeling R-HSA-8963901 8.103463e-01 0.091 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.103463e-01 0.091 0 0
Interleukin-6 signaling R-HSA-1059683 8.103463e-01 0.091 0 0
Processing of SMDT1 R-HSA-8949664 8.103463e-01 0.091 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.103463e-01 0.091 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.103463e-01 0.091 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.103463e-01 0.091 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.103463e-01 0.091 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.103463e-01 0.091 0 0
MET promotes cell motility R-HSA-8875878 8.150854e-01 0.089 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.150854e-01 0.089 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.191980e-01 0.087 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.194430e-01 0.086 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.194430e-01 0.086 0 0
Metalloprotease DUBs R-HSA-5689901 8.194430e-01 0.086 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.194430e-01 0.086 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.194430e-01 0.086 0 0
TRP channels R-HSA-3295583 8.194430e-01 0.086 0 0
Iron uptake and transport R-HSA-917937 8.195938e-01 0.086 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.199984e-01 0.086 0 0
Rab regulation of trafficking R-HSA-9007101 8.219846e-01 0.085 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.220669e-01 0.085 0 0
Signaling by PTK6 R-HSA-8848021 8.220669e-01 0.085 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.220669e-01 0.085 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.264081e-01 0.083 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.264081e-01 0.083 0 0
Meiotic recombination R-HSA-912446 8.272699e-01 0.082 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.274342e-01 0.082 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.280253e-01 0.082 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.280253e-01 0.082 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.280253e-01 0.082 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.280253e-01 0.082 0 0
cGMP effects R-HSA-418457 8.280253e-01 0.082 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.280253e-01 0.082 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.280253e-01 0.082 0 0
Regulation of KIT signaling R-HSA-1433559 8.280253e-01 0.082 0 0
HDL assembly R-HSA-8963896 8.280253e-01 0.082 0 0
Zinc transporters R-HSA-435354 8.280253e-01 0.082 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.280253e-01 0.082 0 0
G alpha (s) signalling events R-HSA-418555 8.285503e-01 0.082 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.324025e-01 0.080 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.324025e-01 0.080 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.324025e-01 0.080 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 8.324025e-01 0.080 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.324025e-01 0.080 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.324025e-01 0.080 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.324025e-01 0.080 0 0
Signaling by BMP R-HSA-201451 8.324025e-01 0.080 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.324025e-01 0.080 0 0
Insulin processing R-HSA-264876 8.324025e-01 0.080 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.324025e-01 0.080 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.339529e-01 0.079 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.339529e-01 0.079 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.339529e-01 0.079 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.343233e-01 0.079 0 0
Translation of Structural Proteins R-HSA-9694635 8.361211e-01 0.078 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.368223e-01 0.077 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.368223e-01 0.077 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.371319e-01 0.077 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.371319e-01 0.077 0 0
HIV Transcription Elongation R-HSA-167169 8.371319e-01 0.077 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.371319e-01 0.077 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.371319e-01 0.077 0 0
Diseases of Immune System R-HSA-5260271 8.371319e-01 0.077 0 0
Ub-specific processing proteases R-HSA-5689880 8.394833e-01 0.076 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.440572e-01 0.074 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.440572e-01 0.074 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.440572e-01 0.074 0 0
Translesion synthesis by REV1 R-HSA-110312 8.440572e-01 0.074 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.440572e-01 0.074 0 0
DCC mediated attractive signaling R-HSA-418885 8.440572e-01 0.074 0 0
Signaling by Activin R-HSA-1502540 8.440572e-01 0.074 0 0
DNA Damage Reversal R-HSA-73942 8.440572e-01 0.074 0 0
Protein repair R-HSA-5676934 8.440572e-01 0.074 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.440572e-01 0.074 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 8.440572e-01 0.074 0 0
p38MAPK events R-HSA-171007 8.440572e-01 0.074 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.440572e-01 0.074 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.440572e-01 0.074 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.440572e-01 0.074 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.442343e-01 0.074 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.445160e-01 0.073 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.445160e-01 0.073 0 0
HIV elongation arrest and recovery R-HSA-167287 8.445160e-01 0.073 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.445160e-01 0.073 0 0
Inflammasomes R-HSA-622312 8.445160e-01 0.073 0 0
Maturation of spike protein R-HSA-9694548 8.472788e-01 0.072 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.478512e-01 0.072 0 0
Protein localization R-HSA-9609507 8.513625e-01 0.070 0 0
Transmission across Chemical Synapses R-HSA-112315 8.546545e-01 0.068 0 0
Signaling by Erythropoietin R-HSA-9006335 8.558285e-01 0.068 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.558285e-01 0.068 0 0
Platelet calcium homeostasis R-HSA-418360 8.558285e-01 0.068 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.558285e-01 0.068 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.558285e-01 0.068 0 0
Intra-Golgi traffic R-HSA-6811438 8.568715e-01 0.067 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.568715e-01 0.067 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.568715e-01 0.067 0 0
Translesion synthesis by POLI R-HSA-5656121 8.585954e-01 0.066 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.585954e-01 0.066 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.585954e-01 0.066 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.585954e-01 0.066 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.585954e-01 0.066 0 0
N-Glycan antennae elongation R-HSA-975577 8.585954e-01 0.066 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.585954e-01 0.066 0 0
Attachment and Entry R-HSA-9678110 8.585954e-01 0.066 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.597559e-01 0.066 0 0
SLC transporter disorders R-HSA-5619102 8.630378e-01 0.064 0 0
Regulated Necrosis R-HSA-5218859 8.632611e-01 0.064 0 0
DAP12 signaling R-HSA-2424491 8.663842e-01 0.062 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.663842e-01 0.062 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.663842e-01 0.062 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.663842e-01 0.062 0 0
Ion homeostasis R-HSA-5578775 8.707062e-01 0.060 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.712471e-01 0.060 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.717791e-01 0.060 0 0
Translesion synthesis by POLK R-HSA-5655862 8.717791e-01 0.060 0 0
Fibronectin matrix formation R-HSA-1566977 8.717791e-01 0.060 0 0
Heme assimilation R-HSA-9927020 8.717791e-01 0.060 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.717791e-01 0.060 0 0
Passive transport by Aquaporins R-HSA-432047 8.717791e-01 0.060 0 0
Synthesis of PG R-HSA-1483148 8.717791e-01 0.060 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.717791e-01 0.060 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.717791e-01 0.060 0 0
TBC/RABGAPs R-HSA-8854214 8.744838e-01 0.058 0 0
Signaling by FGFR4 R-HSA-5654743 8.744838e-01 0.058 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.762256e-01 0.057 0 0
Budding and maturation of HIV virion R-HSA-162588 8.762256e-01 0.057 0 0
Cargo concentration in the ER R-HSA-5694530 8.762256e-01 0.057 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.762601e-01 0.057 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.766997e-01 0.057 0 0
Interleukin-17 signaling R-HSA-448424 8.773376e-01 0.057 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.781658e-01 0.056 0 0
G1 Phase R-HSA-69236 8.825482e-01 0.054 0 0
Cyclin D associated events in G1 R-HSA-69231 8.825482e-01 0.054 0 0
Surfactant metabolism R-HSA-5683826 8.825482e-01 0.054 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.825482e-01 0.054 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.837343e-01 0.054 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.837343e-01 0.054 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.837343e-01 0.054 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.837343e-01 0.054 0 0
Choline catabolism R-HSA-6798163 8.837343e-01 0.054 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.837343e-01 0.054 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.837343e-01 0.054 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.837343e-01 0.054 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.837343e-01 0.054 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.850634e-01 0.053 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.853943e-01 0.053 0 0
Signaling by FGFR3 R-HSA-5654741 8.901474e-01 0.051 0 0
Regulation of beta-cell development R-HSA-186712 8.919710e-01 0.050 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.939301e-01 0.049 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.945754e-01 0.048 0 0
GAB1 signalosome R-HSA-180292 8.945754e-01 0.048 0 0
Tie2 Signaling R-HSA-210993 8.945754e-01 0.048 0 0
Mismatch Repair R-HSA-5358508 8.945754e-01 0.048 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.966519e-01 0.047 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.973032e-01 0.047 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.983449e-01 0.047 0 0
Metabolism of polyamines R-HSA-351202 8.983449e-01 0.047 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.012729e-01 0.045 0 0
Signaling by FGFR in disease R-HSA-1226099 9.018132e-01 0.045 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.018712e-01 0.045 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.018712e-01 0.045 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.018712e-01 0.045 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.019654e-01 0.045 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.044063e-01 0.044 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.044063e-01 0.044 0 0
Specification of the neural plate border R-HSA-9834899 9.044063e-01 0.044 0 0
Amino Acid conjugation R-HSA-156587 9.044063e-01 0.044 0 0
Conjugation of carboxylic acids R-HSA-159424 9.044063e-01 0.044 0 0
Regulation of signaling by CBL R-HSA-912631 9.044063e-01 0.044 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.044063e-01 0.044 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.044063e-01 0.044 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.044063e-01 0.044 0 0
Other interleukin signaling R-HSA-449836 9.044063e-01 0.044 0 0
Diseases of hemostasis R-HSA-9671793 9.044063e-01 0.044 0 0
HDL remodeling R-HSA-8964058 9.044063e-01 0.044 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.044063e-01 0.044 0 0
Adaptive Immune System R-HSA-1280218 9.044809e-01 0.044 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.072252e-01 0.042 0 0
Signal amplification R-HSA-392518 9.092543e-01 0.041 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.092543e-01 0.041 0 0
Hyaluronan metabolism R-HSA-2142845 9.092543e-01 0.041 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.092543e-01 0.041 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.133209e-01 0.039 0 0
Signaling by NODAL R-HSA-1181150 9.133209e-01 0.039 0 0
Pregnenolone biosynthesis R-HSA-196108 9.133209e-01 0.039 0 0
ABC-family proteins mediated transport R-HSA-382556 9.157338e-01 0.038 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.161144e-01 0.038 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.161144e-01 0.038 0 0
Oncogene Induced Senescence R-HSA-2559585 9.161144e-01 0.038 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.161144e-01 0.038 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.163178e-01 0.038 0 0
Interleukin-1 signaling R-HSA-9020702 9.199281e-01 0.036 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.214047e-01 0.036 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.214047e-01 0.036 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.214047e-01 0.036 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.214047e-01 0.036 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.214047e-01 0.036 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.214047e-01 0.036 0 0
ABC transporter disorders R-HSA-5619084 9.219249e-01 0.035 0 0
RUNX2 regulates bone development R-HSA-8941326 9.224847e-01 0.035 0 0
FLT3 signaling in disease R-HSA-9682385 9.224847e-01 0.035 0 0
GPVI-mediated activation cascade R-HSA-114604 9.224847e-01 0.035 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.245177e-01 0.034 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.287350e-01 0.032 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.287350e-01 0.032 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.287350e-01 0.032 0 0
Serine metabolism R-HSA-977347 9.287350e-01 0.032 0 0
Glutathione synthesis and recycling R-HSA-174403 9.287350e-01 0.032 0 0
Attachment and Entry R-HSA-9694614 9.287350e-01 0.032 0 0
Signaling by FGFR2 R-HSA-5654738 9.305416e-01 0.031 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.320686e-01 0.031 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.323779e-01 0.030 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.353821e-01 0.029 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.353821e-01 0.029 0 0
Signaling by KIT in disease R-HSA-9669938 9.353821e-01 0.029 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.353821e-01 0.029 0 0
LDL clearance R-HSA-8964038 9.353821e-01 0.029 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.366799e-01 0.028 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.369739e-01 0.028 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.374236e-01 0.028 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.382994e-01 0.028 0 0
Pentose phosphate pathway R-HSA-71336 9.389659e-01 0.027 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.391786e-01 0.027 0 0
Mitochondrial protein degradation R-HSA-9837999 9.395048e-01 0.027 0 0
Formation of the ureteric bud R-HSA-9830674 9.414095e-01 0.026 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.414095e-01 0.026 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.414095e-01 0.026 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.414095e-01 0.026 0 0
Carnitine shuttle R-HSA-200425 9.414095e-01 0.026 0 0
Syndecan interactions R-HSA-3000170 9.414095e-01 0.026 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.418787e-01 0.026 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.438076e-01 0.025 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.459113e-01 0.024 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.466743e-01 0.024 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.466743e-01 0.024 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.468750e-01 0.024 0 0
Interleukin-6 family signaling R-HSA-6783589 9.468750e-01 0.024 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.468750e-01 0.024 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.468750e-01 0.024 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.468750e-01 0.024 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.480418e-01 0.023 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.480418e-01 0.023 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.480418e-01 0.023 0 0
Signaling by FGFR1 R-HSA-5654736 9.488332e-01 0.023 0 0
Tight junction interactions R-HSA-420029 9.518310e-01 0.021 0 0
Hyaluronan degradation R-HSA-2160916 9.518310e-01 0.021 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.518310e-01 0.021 0 0
Formation of the nephric duct R-HSA-9830364 9.518310e-01 0.021 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.518310e-01 0.021 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.520822e-01 0.021 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.543417e-01 0.020 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.543417e-01 0.020 0 0
Activation of GABAB receptors R-HSA-991365 9.558213e-01 0.020 0 0
GABA B receptor activation R-HSA-977444 9.558213e-01 0.020 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.563249e-01 0.019 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.563249e-01 0.019 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.563249e-01 0.019 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.585321e-01 0.018 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.587835e-01 0.018 0 0
Signaling by SCF-KIT R-HSA-1433557 9.592802e-01 0.018 0 0
Neddylation R-HSA-8951664 9.596756e-01 0.018 0 0
Packaging Of Telomere Ends R-HSA-171306 9.603997e-01 0.018 0 0
DAP12 interactions R-HSA-2172127 9.624784e-01 0.017 0 0
Netrin-1 signaling R-HSA-373752 9.624784e-01 0.017 0 0
Amine ligand-binding receptors R-HSA-375280 9.624784e-01 0.017 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.640947e-01 0.016 0 0
Insulin receptor recycling R-HSA-77387 9.640947e-01 0.016 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.640947e-01 0.016 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.640947e-01 0.016 0 0
Pyroptosis R-HSA-5620971 9.640947e-01 0.016 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.643755e-01 0.016 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.644056e-01 0.016 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.667607e-01 0.015 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.668956e-01 0.015 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.668956e-01 0.015 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.674450e-01 0.014 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.674450e-01 0.014 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.674450e-01 0.014 0 0
Metabolism of proteins R-HSA-392499 9.680516e-01 0.014 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.681660e-01 0.014 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.681660e-01 0.014 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.681947e-01 0.014 0 0
Interleukin-1 family signaling R-HSA-446652 9.688470e-01 0.014 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.693536e-01 0.014 0 0
Leishmania phagocytosis R-HSA-9664417 9.693536e-01 0.014 0 0
Parasite infection R-HSA-9664407 9.693536e-01 0.014 0 0
Toll-like Receptor Cascades R-HSA-168898 9.701350e-01 0.013 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.704829e-01 0.013 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.704829e-01 0.013 0 0
Neurotransmitter clearance R-HSA-112311 9.704829e-01 0.013 0 0
Synthesis of PC R-HSA-1483191 9.706889e-01 0.013 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.706889e-01 0.013 0 0
Post-translational protein modification R-HSA-597592 9.714283e-01 0.013 0 0
Insulin receptor signalling cascade R-HSA-74751 9.714394e-01 0.013 0 0
Ion transport by P-type ATPases R-HSA-936837 9.714394e-01 0.013 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.714394e-01 0.013 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.723562e-01 0.012 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.732375e-01 0.012 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.732375e-01 0.012 0 0
Platelet homeostasis R-HSA-418346 9.732439e-01 0.012 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.757352e-01 0.011 0 0
PI3K Cascade R-HSA-109704 9.771525e-01 0.010 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.779999e-01 0.010 0 0
Cardiogenesis R-HSA-9733709 9.779999e-01 0.010 0 0
Interferon gamma signaling R-HSA-877300 9.782038e-01 0.010 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.798372e-01 0.009 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.800534e-01 0.009 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.800534e-01 0.009 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.800534e-01 0.009 0 0
Heme degradation R-HSA-189483 9.800534e-01 0.009 0 0
Signaling by FGFR R-HSA-190236 9.812430e-01 0.008 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.819153e-01 0.008 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.819153e-01 0.008 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.819153e-01 0.008 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.819153e-01 0.008 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.819153e-01 0.008 0 0
Nucleotide biosynthesis R-HSA-8956320 9.822261e-01 0.008 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.825820e-01 0.008 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.831125e-01 0.007 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.831125e-01 0.007 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.831125e-01 0.007 0 0
Metabolism of cofactors R-HSA-8978934 9.831132e-01 0.007 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.836035e-01 0.007 0 0
Glycosphingolipid transport R-HSA-9845576 9.851342e-01 0.007 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.851342e-01 0.007 0 0
Triglyceride catabolism R-HSA-163560 9.851342e-01 0.007 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.851342e-01 0.007 0 0
PI Metabolism R-HSA-1483255 9.855940e-01 0.006 0 0
Neuronal System R-HSA-112316 9.858273e-01 0.006 0 0
Voltage gated Potassium channels R-HSA-1296072 9.865220e-01 0.006 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.865220e-01 0.006 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.865220e-01 0.006 0 0
Cleavage of the damaged purine R-HSA-110331 9.865220e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.865220e-01 0.006 0 0
Metabolism of folate and pterines R-HSA-196757 9.865220e-01 0.006 0 0
PPARA activates gene expression R-HSA-1989781 9.871020e-01 0.006 0 0
IRS-mediated signalling R-HSA-112399 9.873192e-01 0.006 0 0
Infectious disease R-HSA-5663205 9.874334e-01 0.005 0 0
Depurination R-HSA-73927 9.877804e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.877804e-01 0.005 0 0
RSV-host interactions R-HSA-9833110 9.882123e-01 0.005 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.883511e-01 0.005 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.884726e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.889214e-01 0.005 0 0
Peroxisomal protein import R-HSA-9033241 9.893009e-01 0.005 0 0
Signaling by Insulin receptor R-HSA-74752 9.896051e-01 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.896051e-01 0.005 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.899559e-01 0.004 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.899559e-01 0.004 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.899559e-01 0.004 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.899559e-01 0.004 0 0
Interleukin-10 signaling R-HSA-6783783 9.901362e-01 0.004 0 0
RAB geranylgeranylation R-HSA-8873719 9.901751e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.901751e-01 0.004 0 0
FLT3 Signaling R-HSA-9607240 9.908938e-01 0.004 0 0
Leishmania infection R-HSA-9658195 9.909979e-01 0.004 0 0
Parasitic Infection Pathways R-HSA-9824443 9.909979e-01 0.004 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.910019e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.910019e-01 0.004 0 0
Stimuli-sensing channels R-HSA-2672351 9.910086e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.924024e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.925153e-01 0.003 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.925153e-01 0.003 0 0
Depyrimidination R-HSA-73928 9.925153e-01 0.003 0 0
Mitochondrial translation elongation R-HSA-5389840 9.927654e-01 0.003 0 0
Mitochondrial translation initiation R-HSA-5368286 9.937513e-01 0.003 0 0
Methylation R-HSA-156581 9.938482e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.938482e-01 0.003 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.944228e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.944228e-01 0.002 0 0
Kidney development R-HSA-9830369 9.946141e-01 0.002 0 0
Nicotinate metabolism R-HSA-196807 9.946141e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.950675e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.951340e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.951741e-01 0.002 0 0
Immune System R-HSA-168256 9.954284e-01 0.002 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.956830e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.958444e-01 0.002 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.959785e-01 0.002 0 0
Retinoid metabolism and transport R-HSA-975634 9.961923e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.962327e-01 0.002 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.962327e-01 0.002 0 0
Visual phototransduction R-HSA-2187338 9.964411e-01 0.002 1 0
Neurotransmitter release cycle R-HSA-112310 9.964627e-01 0.002 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.965847e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.965847e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.968010e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.969038e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.969038e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.969038e-01 0.001 0 0
Mitochondrial translation termination R-HSA-5419276 9.974481e-01 0.001 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.976933e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.979089e-01 0.001 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.979348e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.979348e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.979470e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.981085e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.981456e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.982815e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.983171e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.983171e-01 0.001 0 0
Ion channel transport R-HSA-983712 9.983897e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.984139e-01 0.001 0 0
Amyloid fiber formation R-HSA-977225 9.984139e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.985035e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.985878e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.985878e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.986151e-01 0.001 0 0
Disease R-HSA-1643685 9.986223e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.987199e-01 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.990189e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.990464e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.991301e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.993562e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.993562e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.994164e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.995439e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.995653e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.995653e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.995907e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996060e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.996620e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.996763e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.997066e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.997466e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997508e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997561e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.997652e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.997673e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.997815e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.997996e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998123e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.998218e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.998433e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999098e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999159e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999176e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999182e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999248e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999694e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999723e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999791e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999824e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999826e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999871e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999881e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999887e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999907e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999916e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999932e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999956e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999961e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999968e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999968e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999981e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999985e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999990e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999992e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999993e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999995e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999995e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999997e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999997e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways