CAMK2B

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
O00273 S28 Sugiyama DFFA DFF1 DFF45 H13 GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00488 S93 Sugiyama ZNF593 ZT86 STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O00488 Y97 Sugiyama ZNF593 ZT86 KTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVPPRRL
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 S995 Sugiyama PPP1R12A MBS MYPT1 ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15212 T38 Sugiyama PFDN6 HKE2 PFD6 QLQKDLSKSMSGRQKLEAQLtENNIVKEELALLDGsNVVFK
O15460 T532 Sugiyama P4HA2 UNQ290/PRO330 WVSNKWFHERGQEFLRPCGstEVD_________________
O43399 S166 Sugiyama TPD52L2 tVGsAIsRKLGDMRNsAtFKsFEDRVGtIKSKVVGDRENGs
O43399 T163 Sugiyama TPD52L2 ALstVGsAIsRKLGDMRNsAtFKsFEDRVGtIKSKVVGDRE
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60266 S1076 ELM ADCY3 KIAA0511 ARKPHYDIWGNTVNVASRMEsTGVMGNIQVVEETQVILREY
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841 S183 Sugiyama EIF5B IF2 KIAA0741 GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 S66 Sugiyama EIF5B IF2 KIAA0741 KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O60927 T75 Sugiyama PPP1R11 HCGV TCTE5 RRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGHR
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O76070 S124 GPS6|EPSD SNCG BCSG1 PERSYN PRSN APQQEGEAsKEKEEVAEEAQsGGD_________________
O95071 S327 Sugiyama UBR5 EDD EDD1 HYD KIAA0896 LLRERESVLRLRERRWLDGAsFDNERGSTSKEGEPNLDKKN
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218 S188 Sugiyama ZRANB2 ZIS ZNF265 KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95999 S138 GPS6 BCL10 CIPER CLAP KCSSCEPFPDGAtNNLsRsNsDEsNFsEKLRASTVMYHPEG
O96013 S41 Sugiyama PAK4 KIAA1142 VHTGFDQHEQKFTGLPRQWQsLIEESARRPKPLVDPACITS
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 T49 Sugiyama ALDOA ALDA GILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDR
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S210 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 S321 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04406 Y314 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05556 T788 PSP ITGB1 FNRB MDF2 MSK12 KEKMNAKWDtGENPIyKsAVttVVNPKyEGK__________
P05556 T789 PSP ITGB1 FNRB MDF2 MSK12 EKMNAKWDtGENPIyKsAVttVVNPKyEGK___________
P05783 S53 ELM KRT18 CYK18 PIG46 AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S432 GPS6|EPSD KRT8 CYK8 HtKTTSGYAGGLSSAYGGLtsPGLSYSLGSSFGSGAGSSSF
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07101 S19 ELM TH TYH __MPTPDATTPQAKGFRRAVsELDAKQAEAIMVRGQGAPGP
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07237 T453 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG
P07737 T65 Sugiyama PFN1 PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737 Y60 Sugiyama PFN1 FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900 S468 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA GIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKENQ
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238 T459 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEt
P08621 S410 Sugiyama SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1 DEARGGGGGQDNGLEGLGNDsRDMYMESEGGDGYLAPENGY
P08670 S39 GPS6|EPSD VIM GtAsRPsssRsYVttsTRtYsLGsALRPstsRsLyAssPGG
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09234 S48 Sugiyama SNRPC RKHKENVKDYYQKWMEEQAQsLIDKTTAAFQQGKIPPTPFS
P09417 S223 ELM QDPR DHPR SDR33C1 TPLEFLVETFHDWITGKNRPsSGsLIQVVTTEGRTELTPAY
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P10412 S89 Sugiyama H1-4 H1F4 HIST1H1E AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P10412 T92 Sugiyama H1-4 H1F4 HIST1H1E DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P10636 S733 GPS6|EPSD MAPT MAPTL MTBT1 TAU sPVVsGDtsPRHLsNVsstGsIDMVDsPQLAtLADEVSASL
P11717 S1378 Sugiyama IGF2R MPRI QYACPPFDLTECSFKDGAGNsFDLsSLSRYSDNWEAITGTG
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12268 S416 Sugiyama IMPDH2 IMPD2 APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P12955 S162 Sugiyama PEPD PRD SVLLTLRGVNTDSGSVCREAsFDGISKFEVNNTILHPEIVE
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13639 T735 Sugiyama EEF2 EF2 HRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCPEQV
P13639 Y730 Sugiyama EEF2 EF2 HADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQ
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14136 S13 ELM GFAP ________MERRRItsAARRsYVssGEMMVGGLAPGRRLGP
P14136 S17 ELM GFAP ____MERRRItsAARRsYVssGEMMVGGLAPGRRLGPGTRL
P14136 S38 ELM GFAP GEMMVGGLAPGRRLGPGTRLsLARMPPPLPTRVDFSLAGAL
P14921 S251 SIGNOR|iPTMNet ETS1 EWSR2 VTPDNMCMGRTSRGKLGGQDsFEsIEsYDSCDRLtQsWssQ
P14921 S257 SIGNOR|iPTMNet ETS1 EWSR2 CMGRTSRGKLGGQDsFEsIEsYDSCDRLtQsWssQssFNsL
P14921 S282 SIGNOR|iPTMNet ETS1 EWSR2 DRLtQsWssQssFNsLQRVPsyDsFDsEDYPAALPNHKPKG
P14921 S285 SIGNOR|iPTMNet ETS1 EWSR2 tQsWssQssFNsLQRVPsyDsFDsEDYPAALPNHKPKGTFK
P15311 S249 Sugiyama EZR VIL2 EKDDKLtPKIGFPWSEIRNIsFNDKKFVIKPIDKKAPDFVF
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15336 S62 Sugiyama ATF2 CREB2 CREBP1 LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16070 S71 Sugiyama CD44 LHR MDU2 MDU3 MIC4 DLCKAFNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRI
P16083 S80 Sugiyama NQO2 NMOR2 LSNPEVFNyGVEtHEAyKQRsLAsDITDEQKKVREADLVIF
P16220 S142 ELM CREB1 KILNDLssDAPGVPRIEEEKsEEETSAPAITTVTVPTPIYQ
P16401 S92 Sugiyama H1-5 H1F5 HIST1H1B GGYDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16401 T95 Sugiyama H1-5 H1F5 HIST1H1B DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16402 S90 Sugiyama H1-3 H1F3 HIST1H1D AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16402 T93 Sugiyama H1-3 H1F3 HIST1H1D DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16403 S89 Sugiyama H1-2 H1F2 HIST1H1C AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16403 T92 Sugiyama H1-2 H1F2 HIST1H1C DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16615 S38 ELM ATP2A2 ATP2B VNESTGLSLEQVKKLKERWGsNELPAEEGKTLLELVIEQFE
P16949 S16 SIGNOR|EPSD|PSP STMN1 C1orf215 LAP18 OP18 _____MAssDIQVKELEKRAsGQAFELILsPRsKEsVPEFP
P17096 S103 Sugiyama HMGA1 HMGIY PRGRPKKLEKEEEEGIsQEssEEEQ________________
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17600 S568 GPS6|EPSD SYN1 PPAsPsPQRQAGPPQATRQTsVSGPAPPKASGAPPGGQQRQ
P17600 S605 GPS6|EPSD SYN1 QQRQGPPQKPPGPAGPTRQAsQAGPVPRTGPPTTQQPRPSG
P17676 S325 ELM CEBPB TCF5 PP9092 ELTAENERLQKKVEQLSRELsTLRNLFKQLPEPLLAssGHC
P17987 S544 Sugiyama TCP1 CCT1 CCTA ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18859 S57 Sugiyama ATP5PF ATP5A ATP5J ATPM DPIQKLFVDKIREYKSKRQTsGGPVDAssEyQQELERELFK
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P21333 S2523 ELM FLNA FLN FLN1 GPYHIGGsPFKAKVTGPRLVsNHsLHEtsSVFVDsLtKATC
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P22626 T140 Sugiyama HNRNPA2B1 HNRPA2B1 KEDTEEHHLRDyFEEYGKIDtIEIItDRQsGKKRGFGFVtF
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588 S597 Sugiyama EIF4B KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25705 S76 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM EERILGADtsVDLEETGRVLsIGDGIARVHGLRNVQAEEMV
P26038 S249 Sugiyama MSN EQNDRLTPKIGFPWSEIRNIsFNDKKFVIKPIDKKAPDFVF
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26358 S91 Sugiyama DNMT1 AIM CXXC9 DNMT EELSEEGYLAKVKSLLNKDLsLENGAHAYNREVNGRLENGN
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26678 T17 GPS6|EPSD PLN PLB ____MEKVQYLTRSAIRRAstIEMPQQARQKLQNLFINFCL
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P28340 S1064 Sugiyama POLD1 POLD LNALEERFSRLWTQCQRCQGsLHEDVICTSRDCPIFyMRKK
P29692 S86 Sugiyama EEF1D EF1D GPGAssGtsGDHGELVVRIAsLEVENQsLRGVVQELQQAIs
P30040 T62 Sugiyama ERP29 C12orf8 ERP28 DtVtFyKVIPKSKFVLVKFDtQyPyGEKQDEFKRLAENSAS
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30533 S247 Sugiyama LRPAP1 A2MRAP KLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSA
P30626 S111 Sugiyama SRI GFNEFKELWAVLNGWRQHFIsFDTDRSGTVDPQELQKALtt
P31943 S23 Sugiyama HNRNPH1 HNRPH HNRPH1 LGTEGGEGFVVKVRGLPWsCsADEVQRFFSDCKIQNGAQGI
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31947 S64 Sugiyama SFN HME1 LsVAyKNVVGGQRAAWRVLSsIEQKsNEEGsEEKGPEVREY
P31947 S69 Sugiyama SFN HME1 KNVVGGQRAAWRVLSsIEQKsNEEGsEEKGPEVREYREKVE
P32119 S112 Sugiyama PRDX2 NKEFB TDPX1 KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33176 S950 Sugiyama KIF5B KNS KNS1 PAAsPtHPSAIRGGGAFVQNsQPVAVRGGGGKQV_______
P33527 S915 Sugiyama ABCC1 MRP MRP1 QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P35222 S552 SIGNOR CTNNB1 CTNNB OK/SW-cl.35 PRO2286 AIPRLVQLLVRAHQDtQRRtsMGGtQQQFVEGVRMEEIVEG
P35222 T332 SIGNOR CTNNB1 CTNNB OK/SW-cl.35 PRO2286 KLIILASGGPQALVNIMRTytyEKLLWTTSRVLKVLSVCSs
P35222 T472 SIGNOR CTNNB1 CTNNB OK/SW-cl.35 PRO2286 LRAGDREDITEPAICALRHLtSRHQEAEMAQNAVRLHyGLP
P35241 S249 Sugiyama RDX EHDDKLTPKIGFPWSEIRNIsFNDKKFVIKPIDKKAPDFVF
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35270 S213 GPS6|EPSD SPR VLNYAPGPLDTDMQQLARETsVDPDMRKGLQELKAKGKLVD
P35579 S1943 Sugiyama MYH9 RGDLPFVVPRRMARKGAGDGsDEEVDGKADGAEAKPAE___
P35637 S340 Sugiyama FUS TLS PMINLyTDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKEFs
P35637 T338 Sugiyama FUS TLS GQPMINLyTDRETGKLKGEAtVsFDDPPsAKAAIDWFDGKE
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 S365 Sugiyama RPL4 RPL1 RNHKLRVDKAAAAAAALQAKsDEKAAVAGKKPVVGKKGKKA
P37108 T45 Sugiyama SRP14 sVyItLKKYDGRTKPIPKKGtVEGFEPADNKCLLRATDGKK
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P39023 S304 Sugiyama RPL3 OK/SW-cl.32 IYKIGQGyLIKDGKLIKNNAstDyDLSDKSINPLGGFVHYG
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41091 T464 Sugiyama EIF2S3 EIF2G SRRVEKHWRLIGWGQIRRGVtIKPtVDDD____________
P41091 T468 Sugiyama EIF2S3 EIF2G EKHWRLIGWGQIRRGVtIKPtVDDD________________
P41236 S121 Sugiyama PPP1R2 IPP2 ARKLAAAEGLEPKyRIQEQEssGEEDsDLsPEEREKKRQFE
P41236 S122 Sugiyama PPP1R2 IPP2 RKLAAAEGLEPKyRIQEQEssGEEDsDLsPEEREKKRQFEM
P41236 Y114 Sugiyama PPP1R2 IPP2 AMAPDILARKLAAAEGLEPKyRIQEQEssGEEDsDLsPEER
P42224 S727 SIGNOR STAT1 IsVsEVHPSRLQttDNLLPMsPEEFDEVSRIVGsVEFDSMM
P42261 S849 ELM GRIA1 GLUA1 GLUH1 GLUR1 CYKsRsEsKRMKGFCLIPQQsINEAIRTStLPRNsGAGASS
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P42766 T59 Sugiyama RPL35 GAASKLsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyK
P42766 T64 Sugiyama RPL35 LsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyKPLDLR
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43034 S157 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA yEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADMTIKLW
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S1098 Sugiyama MKI67 PAARVTGMKKWPRtPKEEAQsLEDLAGFKELFQtPGPsEEs
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49736 S139 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 QRDREAGRGLGRMRRGLLyDsDEEDEERPARKRRQVERAtE
P49840 S21 SIGNOR GSK3A MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P52272 S528 Sugiyama HNRNPM HNRPM NAGR1 IERMGsGVERMGPAIERMGLsMERMVPAGMGAGLERMGPVM
P52272 S618 Sugiyama HNRNPM HNRPM NAGR1 PALGAGIERMGLAMGGGGGAsFDRAIEMERGNFGGsFAGsF
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S12 Sugiyama SUB1 PC4 RPO2TC1 _________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S198 Sugiyama TPI1 TPI TPQQAQEVHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtC
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60660 T85 Sugiyama MYL6 LDFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVM
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978 S420 Sugiyama HNRNPK HNRPK GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62072 S48 Sugiyama TIMM10 TIM10 ACHRKCVPPHYKEAELSKGEsVCLDRCVSKYLDIHERMGKK
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62258 T229 Sugiyama YWHAE LsEEsyKDstLIMQLLRDNLtLWtsDMQGDGEEQNKEALQD
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280 T28 Sugiyama RPS11 RAyQKQPtIFQNKKRVLLGEtGKEKLPRYYKNIGLGFKtPK
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62979 S123 Sugiyama RPS27A UBA80 UBCEP1 LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63167 S14 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 _______MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNI
P63167 S21 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 S167 Sugiyama YBX1 NSEP1 YB1 RYPRRRGPPRNyQQNyQNsEsGEKNEGsEsAPEGQAQQRRP
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T80 Sugiyama YBX1 NSEP1 YB1 LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKKNNPRKyL
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00341 S904 Sugiyama HDLBP HBP VGL FHRSVMGPKGSRIQQITRDFsVQIKFPDREENAVHSTEPVV
Q00613 S230 ELM HSF1 HSTF1 PLMLNDsGsAHSMPKYSRQFsLEHVHGSGPYSAPSPAYSSS
Q00839 S59 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QAALDDEEAGGRPAMEPGNGsLDLGGDsAGRSGAGLEQEAA
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01650 S35 Sugiyama SLC7A5 CD98LC LAT1 MPE16 AAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNITLLNG
Q01970 S537 SIGNOR|ELM|iPTMNet PLCB3 PGLSNGEEVGLEKPSLEPQKsLGDEGLNRGPyVLGPADRED
Q02539 S92 Sugiyama H1-1 H1F1 HIST1H1A AGyDVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNK
Q02539 T95 Sugiyama H1-1 H1F1 HIST1H1A DVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKAS
Q02952 S248 Sugiyama AKAP12 AKAP250 KESEPKQSTEKPEETLKREQsHAEIsPPAESGQAVEECKEE
Q04637 S1238 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05397 S677 Sugiyama PTK2 FAK FAK1 KCWAYDPSRRPRFTELKAQLsTILEEEKAQQEERMRMEsRR
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830 S152 Sugiyama PRDX1 PAGA PAGB TDPX2 IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830 S30 Sugiyama PRDX1 PAGA PAGB TDPX2 HPAPNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTF
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07020 T85 Sugiyama RPL18 RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q08AD1 S1313 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q12879 S1291 iPTMNet GRIN2A NMDAR2A WAQNNALQLQKNKLRISRQHsyDNIVDKPRELDLSRPSRSI
Q12904 S140 Sugiyama AIMP1 EMAP2 SCYE1 EKKAKEKIEKKGEKKEKKQQsIAGsADSKPIDVSRLDLRIG
Q12959 S232 ELM DLG1 YVNGTDADYEYEEITLERGNsGLGFSIAGGTDNPHIGDDSS
Q13131 T183 SIGNOR|EPSD|PSP PRKAA1 AMPK1 NAKIADFGLsNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
Q13206 S831 Sugiyama DDX10 DMENKISDTKKKQGMKKRsNsEVEDVGPTsHNRKKARWDTL
Q13224 S1303 SIGNOR|iPTMNet GRIN2B NMDAR2B QSPTNSKAQKKNRNKLRRQHsYDTFVDLQKEEAALAPRSVs
Q13224 S383 iPTMNet GRIN2B NMDAR2B VIILLNKERKWERVGKWKDKsLQMKYYVWPRMCPETEEQED
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442 S57 Sugiyama PDAP1 HASPP28 EEEQKEGGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGV
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13554 S26 Sugiyama CAMK2B CAM2 CAMK2 CAMKB TCTRFTDEYQLYEDIGKGAFsVVRRCVKLCTGHEYAAKIIN
Q13554 S280 Sugiyama CAMK2B CAM2 CAMK2 CAMKB RITAHEALKHPWVCQRstVAsMMHRQEtVECLKKFNARRKL
Q13554 T277 Sugiyama CAMK2B CAM2 CAMK2 CAMKB PAKRITAHEALKHPWVCQRstVAsMMHRQEtVECLKKFNAR
Q13554 T287 GPS6|SIGNOR|iPTMNet|EPSD|Sugiyama CAMK2B CAM2 CAMK2 CAMKB LKHPWVCQRstVAsMMHRQEtVECLKKFNARRKLKGAILtt
Q13554 T306 Sugiyama CAMK2B CAM2 CAMK2 CAMKB EtVECLKKFNARRKLKGAILttMLAtRNFSVGRQTtAPAtM
Q13554 T307 Sugiyama CAMK2B CAM2 CAMK2 CAMKB tVECLKKFNARRKLKGAILttMLAtRNFSVGRQTtAPAtMS
Q13554 T382 GPS6 CAMK2B CAM2 CAMK2 CAMKB SAAATSPKGTLPPAALEPQttVIHNPVDGIKEssDsANttI
Q13555 S26 Sugiyama CAMK2G CAMK CAMK-II CAMKG TCTRFTDDYQLFEELGKGAFsVVRRCVKKTstQEYAAKIIN
Q13555 S280 Sugiyama CAMK2G CAMK CAMK-II CAMKG RITADQALKHPWVCQRstVAsMMHRQEtVECLRKFNARRKL
Q13555 T277 Sugiyama CAMK2G CAMK CAMK-II CAMKG PAKRITADQALKHPWVCQRstVAsMMHRQEtVECLRKFNAR
Q13555 T287 PSP CAMK2G CAMK CAMK-II CAMKG LKHPWVCQRstVAsMMHRQEtVECLRKFNARRKLKGAILtt
Q13557 S26 Sugiyama CAMK2D CAMKD TCTRFTDEyQLFEELGKGAFsVVRRCMKIPTGQEYAAKIIN
Q13557 S280 Sugiyama CAMK2D CAMKD RItAsEALKHPWICQRstVAsMMHRQEtVDCLKKFNARRKL
Q13557 T277 Sugiyama CAMK2D CAMKD PAKRItAsEALKHPWICQRstVAsMMHRQEtVDCLKKFNAR
Q13557 T306 Sugiyama CAMK2D CAMKD EtVDCLKKFNARRKLKGAILttMLAtRNFsAAKsLLKKPDG
Q13557 T307 Sugiyama CAMK2D CAMKD tVDCLKKFNARRKLKGAILttMLAtRNFsAAKsLLKKPDGV
Q14126 S551 Sugiyama DSG2 CDHF5 FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14151 S613 Sugiyama SAFB2 KIAA0138 ERSSKSQDRKSESKEKRDILsFDKIKEQRERERQRQREREI
Q14157 T239 Sugiyama UBAP2L KIAA0144 NICE4 GNTWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIF
Q14157 T241 Sugiyama UBAP2L KIAA0144 NICE4 TWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIFtA
Q14157 T246 Sugiyama UBAP2L KIAA0144 NICE4 GHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIFtAsNVss
Q14192 S238 Sugiyama FHL2 DRAL SLIM3 AKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKCsLsL
Q14247 S282 Sugiyama CTTN EMS1 QKDyKTGFGGKFGVQsERQDsAAVGFDyKEKLAKHEsQQDy
Q14498 S337 Sugiyama RBM39 HCC1 RNPC2 AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL
Q14524 S516 SIGNOR SCN5A KsDsEDGPRAMNHLsLTRGLsRTSMKPRssRGsIFTFRRRD
Q14524 S571 SIGNOR SCN5A AGESESHHTSLLVPWPLRRtsAQGQPsPGTSAPGHALHGKK
Q14524 T594 SIGNOR SCN5A GQPsPGTSAPGHALHGKKNStVDCNGVVSLLGAGDPEATSP
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14738 S598 Sugiyama PPP2R5D DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14847 S99 Sugiyama LASP1 MLN50 ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14966 S1228 Sugiyama ZNF638 NP220 ZFML DLEKKGAEIINPKTALLPSDsVFAEERNLKGILEEsPsEAE
Q14978 S87 Sugiyama NOLC1 KIAA0035 NS5ATP13 KLQANGPVAKKAKKKAsssDsEDssEEEEEVQGPPAKKAAV
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15084 S169 Sugiyama PDIA6 ERP5 P5 TXNDC7 GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW
Q15121 S116 ELM PEA15 DtKLtRIPsAKKYKDIIRQPsEEEIIKLAPPPKKA______
Q15459 S690 Sugiyama SF3A1 SAP114 VHPPPPMEDEPTSKKLKTEDsLMPEEEFLRRNKGPVSIKVQ
Q15527 S183 Sugiyama SURF2 sDDsMtDLYPPELFTRKDLGstEDGDGtDDFLtDKEDEKAK
Q15527 T184 Sugiyama SURF2 DDsMtDLYPPELFTRKDLGstEDGDGtDDFLtDKEDEKAKP
Q15796 S240 EPSD SMAD2 MADH2 MADR2 tPPPGYISEDGETSDQQLNQsMDtGsPAELsPTTLsPVNHs
Q15906 T137 ELM VPS72 TCFL1 YL1 LLPLELQDDGsDsRKsMRQStAEHTRQTFLRVQERQGQSRR
Q15906 T168 ELM VPS72 TCFL1 YL1 VQERQGQSRRRKGPHCERPLtQEELLREAKITEELNLRSLE
Q15906 T86 ELM VPS72 TCFL1 YL1 GDEPSsDGEAEEPRRKRRVVtKAYKEPLKSLRPRKVNTPAG
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16625 S471 EPSD|PSP OCLN DEINKELSRLDKELDDYREEsEEyMAAADEYNRLKQVKGsA
Q2VIR3 T464 Sugiyama EIF2S3B SRRVEKHWRLIGWGQIRRGVtIKPtVDDD____________
Q2VIR3 T468 Sugiyama EIF2S3B EKHWRLIGWGQIRRGVtIKPtVDDD________________
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q3ZCM7 S75 Sugiyama TUBB8 SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q3ZCM7 T72 Sugiyama TUBB8 NEASGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIF
Q53EL6 S76 Sugiyama PDCD4 H731 NAKAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPK
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q5H9R7 S579 Sugiyama PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6GYQ0 T798 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z4V5 S370 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 KERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGRG
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86UE4 S298 Sugiyama MTDH AEG1 LYRIC NLTVNGGGWNEKSVKLssQIsAGEEKWNsVsPAsAGKRKtE
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8N6H7 S368 Sugiyama ARFGAP2 ZNF289 Nbla10535 VGTFASGPPKYKDNPFsLGEsFGsRWDTDAAWGMDRVEEKE
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NE71 S105 Sugiyama ABCF1 ABC50 KKDVDDDGEEKELMERLKKLsVPtsDEEDEVPAPKPRGGKK
Q8NE71 S166 Sugiyama ABCF1 ABC50 EEKHPPKPAKPEKNRINKAVsEEQQPALKGKKGKEEKSKGK
Q8NE71 S595 Sugiyama ABCF1 ABC50 TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NE71 T108 Sugiyama ABCF1 ABC50 VDDDGEEKELMERLKKLsVPtsDEEDEVPAPKPRGGKKTKG
Q8NEY1 S808 Sugiyama NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1 TAKSFVKPPsLANLDKVNsNsLDLPSSSDTTHASKVPDLHA
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TEQ6 S757 Sugiyama GEMIN5 PKAKPKKKKKPTLRtPVKLEsIDGNEEEsMKENsGPVENGV
Q8TEU7 S1117 Sugiyama RAPGEF6 PDZGEF2 NAKKLYEDAQMARKVKQYLssLDVETDEEKFQMMSLQWEPA
Q8WWI1 S704 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 KKRLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEM
Q8WWI1 S709 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 VERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQKIKS
Q8WX93 S479 Sugiyama PALLD KIAA0992 CGI-151 VLECRVRGAPPLQVQWFRQGsEIQDsPDFRILQKKPRSTAE
Q92609 S541 Sugiyama TBC1D5 KIAA0210 EsMPVQLNKGLSSKNIsssPsVEsLPGGREFtGsPPssAtK
Q92804 S289 Sugiyama TAF15 RBP56 TAF2N PMINLYTDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKEFH
Q92804 T287 Sugiyama TAF15 RBP56 TAF2N GKPMINLYTDKDTGKPKGEAtVsFDDPPsAKAAIDWFDGKE
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96AT1 S146 Sugiyama KIAA1143 VNQDsVKKNSQKQIKNssLLsFDNEDENE____________
Q96CT7 S141 Sugiyama CCDC124 KsHLEVPLEENVNRRVLEEGsVEARTIEDAIAVLsVAEEAA
Q99497 S57 Sugiyama PARK7 GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q99575 S816 Sugiyama POP1 KIAA0061 VAATGSHLCVLRSRKLLKQLsAWCGPSSEDSRGGRRAPGRG
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99755 S486 Sugiyama PIP5K1A GssFSRRAGssGNsCItyQPsVsGEHKAQVTTKAEVEPGVH
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BTE6 S174 Sugiyama AARSD1 IEQSVNEKIRDRLPVNVRELsLDDPEVEQVsGRGLPDDHAG
Q9BY44 S526 Sugiyama EIF2A CDA02 MSTP004 MSTP089 sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9C0C2 S1621 Sugiyama TNKS1BP1 KIAA1741 TAB182 DsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRMsLGTK
Q9C0C2 S221 Sugiyama TNKS1BP1 KIAA1741 TAB182 TyGtTTAPRDEDGstLFRGWsQEGPVKsPAECREEHsKtPE
Q9C0C2 S899 Sugiyama TNKS1BP1 KIAA1741 TAB182 RDVsLGDWEFGKRDsLGAyAsQDANEQGQDLGKRDHHGRys
Q9H1E3 S113 Sugiyama NUCKS1 NUCKS JC7 RQAASKAASKQREMLMEDVGsEEEQEEEDEAPFQEKDsGsD
Q9H6L5 S151 SIGNOR|PSP RETREG1 FAM134B JK1 QIIKDMVLSRTRGAQLWRSLsEsWEVINSKPDERPRLSHCI
Q9H6S3 S693 Sugiyama EPS8L2 EPS8R2 PP13181 EGVRVySQLTMQKAFLEKQQsGSELEELMNKFHSMNQRRGE
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9NQC7 S362 SIGNOR CYLD CYLD1 KIAA0849 HSPC057 STSDPGNRNRSELFYTLNGSsVDSQPQSKSKNTWYIDEVAE
Q9NQC7 S418 SIGNOR CYLD CYLD1 KIAA0849 HSPC057 ssPPLQPPPVNSLTTENRFHsLPFsLtKMPNTNGsIGHsPL
Q9NQC7 S772 SIGNOR CYLD CYLD1 KIAA0849 HSPC057 LIIQMPRFGKDFKLFKKIFPsLELNITDLLEDTPRQCRICG
Q9NQZ2 T397 Sugiyama UTP3 CRLZ1 SAS10 KYYKEIEDRQKLKRKKEENstEEQALEDQNAKRAItyQIAK
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NUU7 T467 Sugiyama DDX19A DDX19L SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NYF8 S198 Sugiyama BCLAF1 BTF KIAA0164 PLKsKsQEEPKDtFEHDPsEsIDEFNKssAtsGDIWPGLsA
Q9NZV8 S438 ELM KCND2 KIAA1044 RADKRRAQKKARLARIRAAKsGSANAYMQSKRNGLLSNQLQ
Q9NZV8 S459 ELM KCND2 KIAA1044 GSANAYMQSKRNGLLSNQLQsSEDEQAFVSKSGSSFETQHH
Q9UBS5 S868 SIGNOR GABBR1 GPRC3A TLVVLFVPKMRRLITRGEWQsEAQDtMKTGSstNNNEEEKS
Q9UBS5 T873 SIGNOR GABBR1 GPRC3A FVPKMRRLITRGEWQsEAQDtMKTGSstNNNEEEKSRLLEK
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9ULD2 S1203 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9ULD2 T1204 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs
Q9UMR2 T468 Sugiyama DDX19B DBP5 DDX19 TDBP SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UNZ2 S192 Sugiyama NSFL1C UBXN2C KRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQFLEs
Q9UPQ0 S201 Sugiyama LIMCH1 KIAA1102 DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UQD0 S561 SIGNOR SCN8A MED sIMNQSLLSIPGSPFLSRHNsKSSIFSFRGPGRFRDPGSEN
Q9UQD0 S641 SIGNOR SCN8A MED SQGSRSSRIFPSLRRSVKRNstVDCNGVVSLIGGPGSHIGG
Q9UQD0 T642 SIGNOR SCN8A MED QGSRSSRIFPSLRRSVKRNstVDCNGVVSLIGGPGSHIGGR
Q9UQM7 S25 Sugiyama CAMK2A CAMKA KIAA0968 TCTRFTEEYQLFEELGKGAFsVVRRCVKVLAGQEYAAKIIN
Q9UQM7 T305 Sugiyama CAMK2A CAMKA KIAA0968 EtVDCLKKFNARRKLKGAILttMLAtRNFsGGKSGGNKKSD
Q9UQM7 T306 Sugiyama CAMK2A CAMKA KIAA0968 tVDCLKKFNARRKLKGAILttMLAtRNFsGGKSGGNKKSDG
Q9Y237 S72 Sugiyama PIN4 MEAMEKLKSGMRFNEVAAQysEDKARQGGDLGWMTRGSMVG
Q9Y281 S24 ELM CFL2 GVtVNDEVIKVFNDMKVRKsstQEEIKKRKKAVLFCLSDDK
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7 T115 Sugiyama YBX2 CSDA3 MSY2 LGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIKRNNPRKFL
Q9Y3F4 S153 Sugiyama STRAP MAWD UNRIP EAEPKEISGHTSGIKKALWCsEDKQILsADDKtVRLWDHAT
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y4W2 S641 Sugiyama LAS1L MSTP060 ENARLLAQKRGALQGsAWQVssEDVRWDTFPLGRMPGQTED
Q9Y4W2 S642 Sugiyama LAS1L MSTP060 NARLLAQKRGALQGsAWQVssEDVRWDTFPLGRMPGQTEDP
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y608 S18 Sugiyama LRRFIP2 ___MGTPASGRKRTPVKDRFsAEDEALsNIAREAEARLAAK
Q9Y6K9 S196 Sugiyama IKBKG FIP3 NEMO AASEQARQLESEREALQQQHsVQVDQLRMQGQSVEAALRME
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.000004 5.352 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000007 5.171 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.000145 3.838 1 0
Apoptotic execution phase R-HSA-75153 0.000157 3.803 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.000396 3.403 1 0
mRNA Splicing - Major Pathway R-HSA-72163 0.000347 3.459 0 0
mRNA Splicing R-HSA-72172 0.000302 3.521 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.000396 3.403 1 1
Post NMDA receptor activation events R-HSA-438064 0.000421 3.376 1 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.000444 3.353 0 0
Signaling by ALK in cancer R-HSA-9700206 0.000444 3.353 0 0
NRAGE signals death through JNK R-HSA-193648 0.000435 3.362 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.000487 3.313 1 0
Nervous system development R-HSA-9675108 0.000617 3.210 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.000689 3.162 0 0
Metabolism of RNA R-HSA-8953854 0.000729 3.137 0 0
Axon guidance R-HSA-422475 0.000810 3.092 0 0
Chromatin organization R-HSA-4839726 0.000932 3.030 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.001225 2.912 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.001488 2.827 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.001855 2.732 0 0
Signaling by Hippo R-HSA-2028269 0.001735 2.761 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.001860 2.730 1 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.002033 2.692 1 1
Chromatin modifying enzymes R-HSA-3247509 0.002212 2.655 0 0
Signaling by VEGF R-HSA-194138 0.002511 2.600 0 0
Signaling by EGFR R-HSA-177929 0.002666 2.574 0 0
RET signaling R-HSA-8853659 0.002800 2.553 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.002881 2.541 0 0
Cell Cycle R-HSA-1640170 0.002964 2.528 0 0
Neurexins and neuroligins R-HSA-6794361 0.003367 2.473 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 0.003499 2.456 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.005216 2.283 0 0
Long-term potentiation R-HSA-9620244 0.005297 2.276 1 1
G alpha (12/13) signalling events R-HSA-416482 0.005195 2.284 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.005143 2.289 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.005385 2.269 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.005717 2.243 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.006480 2.188 1 1
Amplification of signal from the kinetochores R-HSA-141424 0.006583 2.182 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.006583 2.182 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.006129 2.213 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.006547 2.184 0 0
DAG and IP3 signaling R-HSA-1489509 0.006309 2.200 1 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.006480 2.188 1 1
Nuclear Envelope Breakdown R-HSA-2980766 0.007017 2.154 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.007404 2.131 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.007845 2.105 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.008011 2.096 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.009307 2.031 1 1
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.009862 2.006 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.010453 1.981 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.010772 1.968 0 0
Cell Cycle Checkpoints R-HSA-69620 0.010933 1.961 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.011009 1.958 0 0
RSK activation R-HSA-444257 0.011706 1.932 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.011706 1.932 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.011910 1.924 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.011910 1.924 0 0
Mitotic Prometaphase R-HSA-68877 0.012889 1.890 0 0
Nephrin family interactions R-HSA-373753 0.012438 1.905 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.013859 1.858 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.015354 1.814 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.015727 1.803 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.014808 1.829 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.014808 1.829 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.015557 1.808 1 0
PKMTs methylate histone lysines R-HSA-3214841 0.016042 1.795 0 0
Cell Cycle, Mitotic R-HSA-69278 0.015401 1.812 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.017103 1.767 0 0
Trafficking of AMPA receptors R-HSA-399719 0.016528 1.782 1 1
Formation of RNA Pol II elongation complex R-HSA-112382 0.016843 1.774 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.017103 1.767 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.018475 1.733 1 1
Signaling by FGFR1 in disease R-HSA-5655302 0.018475 1.733 0 0
Calmodulin induced events R-HSA-111933 0.017714 1.752 1 0
CaM pathway R-HSA-111997 0.017714 1.752 1 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.018712 1.728 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.019068 1.720 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.023884 1.622 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.023721 1.625 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.021127 1.675 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.022702 1.644 1 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.022702 1.644 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.021481 1.668 1 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.020749 1.683 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 0.023638 1.626 0 0
CREB phosphorylation R-HSA-199920 0.024961 1.603 0 0
Ca-dependent events R-HSA-111996 0.021173 1.674 1 0
Cellular Senescence R-HSA-2559583 0.020964 1.679 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.022238 1.653 1 1
Death Receptor Signaling R-HSA-73887 0.021357 1.670 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 0.024988 1.602 0 0
Striated Muscle Contraction R-HSA-390522 0.026347 1.579 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.026347 1.579 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.026995 1.569 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.027073 1.567 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.027220 1.565 0 0
Netrin-1 signaling R-HSA-373752 0.027431 1.562 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.029256 1.534 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.029467 1.531 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.029512 1.530 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.029542 1.530 0 0
DCC mediated attractive signaling R-HSA-418885 0.029934 1.524 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.029934 1.524 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.029934 1.524 0 0
Deadenylation of mRNA R-HSA-429947 0.032070 1.494 0 0
mRNA 3'-end processing R-HSA-72187 0.034409 1.463 0 0
Cell-Cell communication R-HSA-1500931 0.034662 1.460 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.034678 1.460 0 0
Signaling by RAS mutants R-HSA-6802949 0.034934 1.457 1 0
Signaling downstream of RAS mutants R-HSA-9649948 0.034934 1.457 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.034934 1.457 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.034934 1.457 1 1
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.035233 1.453 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.035739 1.447 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 0.037424 1.427 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 0.037424 1.427 0 0
M Phase R-HSA-68886 0.036515 1.438 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 0.037424 1.427 0 0
Signal Transduction R-HSA-162582 0.036322 1.440 1 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.039178 1.407 0 0
FLT3 signaling in disease R-HSA-9682385 0.039760 1.401 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.039852 1.400 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.040188 1.396 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.044844 1.348 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.045117 1.346 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.042002 1.377 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.045914 1.338 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.042820 1.368 0 0
PLC beta mediated events R-HSA-112043 0.045558 1.341 1 0
Cellular response to heat stress R-HSA-3371556 0.044073 1.356 1 0
Membrane Trafficking R-HSA-199991 0.042291 1.374 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.043790 1.359 0 0
Co-stimulation by ICOS R-HSA-9927354 0.046302 1.334 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.046302 1.334 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.047106 1.327 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.048160 1.317 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.048830 1.311 0 0
Centrosome maturation R-HSA-380287 0.050076 1.300 0 0
Heme signaling R-HSA-9707616 0.050112 1.300 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.050722 1.295 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.051269 1.290 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.053766 1.269 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.053766 1.269 0 0
Notch-HLH transcription pathway R-HSA-350054 0.057026 1.244 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.054971 1.260 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.054971 1.260 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.055831 1.253 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.058142 1.236 0 0
Semaphorin interactions R-HSA-373755 0.054971 1.260 0 0
Lipophagy R-HSA-9613354 0.059831 1.223 0 0
Ephrin signaling R-HSA-3928664 0.063690 1.196 0 0
Polo-like kinase mediated events R-HSA-156711 0.063690 1.196 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.063690 1.196 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.063690 1.196 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.064038 1.194 0 0
RAF activation R-HSA-5673000 0.065580 1.183 1 1
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.065632 1.183 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.066396 1.178 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.066396 1.178 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.066396 1.178 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.085486 1.068 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.085486 1.068 0 0
Regulation of cortical dendrite branching R-HSA-8985801 0.085486 1.068 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.085486 1.068 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.085486 1.068 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.085486 1.068 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.085486 1.068 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.085486 1.068 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.085486 1.068 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.085486 1.068 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.085486 1.068 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.085486 1.068 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.074601 1.127 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.075226 1.124 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.075226 1.124 0 0
2-LTR circle formation R-HSA-164843 0.075226 1.124 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.083728 1.077 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.074619 1.127 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.075832 1.120 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.075238 1.124 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.084756 1.072 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.084756 1.072 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.073592 1.133 0 0
Recycling pathway of L1 R-HSA-437239 0.075818 1.120 0 0
Metabolism of non-coding RNA R-HSA-194441 0.068998 1.161 0 0
snRNP Assembly R-HSA-191859 0.068998 1.161 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.082006 1.086 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.073369 1.134 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.075238 1.124 0 0
Downstream signal transduction R-HSA-186763 0.084756 1.072 0 0
EGFR downregulation R-HSA-182971 0.084756 1.072 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.073369 1.134 0 0
PI3K/AKT activation R-HSA-198203 0.075226 1.124 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.079123 1.102 1 1
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.074619 1.127 0 0
L1CAM interactions R-HSA-373760 0.077857 1.109 0 0
Gene expression (Transcription) R-HSA-74160 0.080179 1.096 1 0
Signaling by FGFR in disease R-HSA-1226099 0.079330 1.101 0 0
Neurodegenerative Diseases R-HSA-8863678 0.075832 1.120 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.075832 1.120 0 0
G-protein mediated events R-HSA-112040 0.077588 1.110 1 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.086446 1.063 0 0
Interleukin-7 signaling R-HSA-1266695 0.086446 1.063 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.086547 1.063 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.086547 1.063 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.086547 1.063 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.086547 1.063 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.086547 1.063 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.086547 1.063 0 0
Separation of Sister Chromatids R-HSA-2467813 0.087276 1.059 0 0
MAPK family signaling cascades R-HSA-5683057 0.087584 1.058 1 0
Drug resistance of PDGFR mutants R-HSA-9674415 0.114054 0.943 0 0
PDGFR mutants bind TKIs R-HSA-9674428 0.114054 0.943 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 0.114054 0.943 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 0.114054 0.943 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 0.114054 0.943 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 0.114054 0.943 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 0.114054 0.943 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.114054 0.943 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.215105 0.667 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.215105 0.667 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.215105 0.667 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.215105 0.667 0 0
TICAM1 deficiency - HSE R-HSA-5602566 0.215105 0.667 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 0.215105 0.667 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 0.215105 0.667 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.215105 0.667 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.123688 0.908 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.123688 0.908 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.123688 0.908 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.097499 1.011 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.097499 1.011 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 0.165075 0.782 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.165075 0.782 0 0
TNFR1-mediated ceramide production R-HSA-5626978 0.165075 0.782 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 0.165075 0.782 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.165075 0.782 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.165075 0.782 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 0.165075 0.782 0 0
FGFR4 mutant receptor activation R-HSA-1839128 0.304636 0.516 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 0.304636 0.516 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 0.304636 0.516 0 0
TRAF3 deficiency - HSE R-HSA-5602571 0.304636 0.516 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 0.304636 0.516 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 0.304636 0.516 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 0.304636 0.516 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 0.304636 0.516 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 0.304636 0.516 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 0.304636 0.516 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 0.122844 0.911 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.122844 0.911 0 0
Disinhibition of SNARE formation R-HSA-114516 0.122844 0.911 0 0
SOS-mediated signalling R-HSA-112412 0.122844 0.911 0 0
PECAM1 interactions R-HSA-210990 0.092408 1.034 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.208423 0.681 0 0
IRS activation R-HSA-74713 0.208423 0.681 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.208423 0.681 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 0.208423 0.681 0 0
Type I hemidesmosome assembly R-HSA-446107 0.150277 0.823 0 0
Formation of annular gap junctions R-HSA-196025 0.150277 0.823 0 0
Activation of RAC1 R-HSA-428540 0.111273 0.954 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.111273 0.954 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.098511 1.007 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.131691 0.880 0 0
Gap junction degradation R-HSA-190873 0.179437 0.746 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.179437 0.746 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.252749 0.597 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.252749 0.597 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 0.252749 0.597 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 0.383959 0.416 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 0.383959 0.416 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 0.383959 0.416 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 0.383959 0.416 0 0
Signaling by RAS GAP mutants R-HSA-9753510 0.383959 0.416 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 0.383959 0.416 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 0.383959 0.416 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.153514 0.814 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.153514 0.814 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.099456 1.002 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.099456 1.002 0 0
Folding of actin by CCT/TriC R-HSA-390450 0.209962 0.678 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.209962 0.678 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.176585 0.753 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 0.297265 0.527 0 0
Autointegration results in viral DNA circles R-HSA-177539 0.297265 0.527 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.297265 0.527 0 0
GAB1 signalosome R-HSA-180292 0.149891 0.824 0 0
Signaling by APC mutants R-HSA-4839744 0.241511 0.617 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.241511 0.617 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.241511 0.617 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.241511 0.617 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.110059 0.958 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.110059 0.958 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.200734 0.697 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.200734 0.697 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.200734 0.697 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.169112 0.772 0 0
HIV elongation arrest and recovery R-HSA-167287 0.123025 0.910 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.123025 0.910 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.105802 0.976 0 0
Signaling by Erythropoietin R-HSA-9006335 0.136732 0.864 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.160257 0.795 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.189231 0.723 0 0
Phosphorylation of the APC/C R-HSA-176412 0.225793 0.646 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.273760 0.563 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.273760 0.563 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.273760 0.563 0 0
MECP2 regulates transcription factors R-HSA-9022707 0.341352 0.467 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 0.341352 0.467 0 0
Regulation of PTEN localization R-HSA-8948747 0.341352 0.467 0 0
VLDL clearance R-HSA-8964046 0.341352 0.467 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 0.341352 0.467 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.341352 0.467 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 0.454237 0.343 0 0
PLC-gamma1 signalling R-HSA-167021 0.454237 0.343 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 0.454237 0.343 0 0
MET activates PTPN11 R-HSA-8865999 0.454237 0.343 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.454237 0.343 0 0
Invadopodia formation R-HSA-8941237 0.454237 0.343 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.454237 0.343 0 0
Defective ABCC2 causes DJS R-HSA-5679001 0.454237 0.343 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.111408 0.953 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.129466 0.888 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.177518 0.751 0 0
HIV Transcription Elongation R-HSA-167169 0.122285 0.913 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.122285 0.913 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.122285 0.913 0 0
Disorders of Developmental Biology R-HSA-9675151 0.251591 0.599 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.251591 0.599 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.195490 0.709 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.306411 0.514 0 0
Pervasive developmental disorders R-HSA-9005895 0.306411 0.514 0 0
Disorders of Nervous System Development R-HSA-9697154 0.306411 0.514 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.306411 0.514 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.306411 0.514 0 0
Scavenging by Class F Receptors R-HSA-3000484 0.306411 0.514 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.306411 0.514 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.306411 0.514 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.306411 0.514 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.306411 0.514 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.231772 0.635 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.169550 0.771 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.277959 0.556 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 0.384529 0.415 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.384529 0.415 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.384529 0.415 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.384529 0.415 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 0.384529 0.415 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.384529 0.415 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.253988 0.595 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.233302 0.632 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.233302 0.632 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.339195 0.470 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.304736 0.516 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.253005 0.597 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.212805 0.672 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.273143 0.564 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.331768 0.479 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 0.371870 0.430 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.371870 0.430 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 0.426429 0.370 0 0
ARMS-mediated activation R-HSA-170984 0.426429 0.370 0 0
Calcineurin activates NFAT R-HSA-2025928 0.426429 0.370 0 0
ALK mutants bind TKIs R-HSA-9700645 0.426429 0.370 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 0.516502 0.287 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 0.516502 0.287 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.516502 0.287 0 0
betaKlotho-mediated ligand binding R-HSA-1307965 0.516502 0.287 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 0.516502 0.287 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.516502 0.287 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.516502 0.287 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 0.516502 0.287 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 0.516502 0.287 0 0
RUNX2 regulates bone development R-HSA-8941326 0.268522 0.571 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.268522 0.571 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 0.358908 0.445 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 0.404224 0.393 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.404224 0.393 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.404224 0.393 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.404224 0.393 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.386021 0.413 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.386021 0.413 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.466784 0.331 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 0.466784 0.331 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.466784 0.331 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.466784 0.331 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.370410 0.431 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.356623 0.448 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.356623 0.448 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.436073 0.360 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.266923 0.574 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.251832 0.599 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.251832 0.599 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.328181 0.484 0 0
Transcription of the HIV genome R-HSA-167172 0.318139 0.497 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.291593 0.535 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.283699 0.547 0 0
Late endosomal microautophagy R-HSA-9615710 0.417670 0.379 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.467260 0.330 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 0.505399 0.296 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.505399 0.296 0 0
Activation of AMPA receptors R-HSA-399710 0.571666 0.243 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.571666 0.243 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 0.571666 0.243 0 0
Defective F9 activation R-HSA-9673221 0.571666 0.243 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 0.571666 0.243 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.571666 0.243 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 0.571666 0.243 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.291184 0.536 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.404799 0.393 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.466004 0.332 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.283224 0.548 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.497653 0.303 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.383854 0.416 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 0.542147 0.266 0 0
Nucleosome assembly R-HSA-774815 0.460642 0.337 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.460642 0.337 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.439414 0.357 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.408394 0.389 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.408394 0.389 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.527144 0.278 0 0
Tight junction interactions R-HSA-420029 0.517201 0.286 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.450476 0.346 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.444566 0.352 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.541922 0.266 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 0.555647 0.255 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.555647 0.255 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.576951 0.239 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.576951 0.239 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 0.620539 0.207 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 0.620539 0.207 0 0
Cam-PDE 1 activation R-HSA-111957 0.620539 0.207 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.620539 0.207 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 0.620539 0.207 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.620539 0.207 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 0.620539 0.207 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 0.620539 0.207 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 0.620539 0.207 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.553546 0.257 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.579617 0.237 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.589318 0.230 0 0
Meiotic synapsis R-HSA-1221632 0.606567 0.217 0 0
RNA Polymerase III Transcription R-HSA-74158 0.268522 0.571 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.332567 0.478 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.286856 0.542 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.501954 0.299 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.304736 0.516 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.441102 0.355 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.439677 0.357 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.189231 0.723 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.277959 0.556 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.557191 0.254 0 0
Circadian clock R-HSA-9909396 0.524449 0.280 0 0
Prolonged ERK activation events R-HSA-169893 0.436073 0.360 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.179437 0.746 0 0
Platelet sensitization by LDL R-HSA-432142 0.149891 0.824 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.210152 0.677 0 0
TCR signaling R-HSA-202403 0.511302 0.291 0 0
DAP12 signaling R-HSA-2424491 0.441102 0.355 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.427358 0.369 0 0
mTORC1-mediated signalling R-HSA-166208 0.253988 0.595 0 0
TGFBR3 expression R-HSA-9839394 0.517201 0.286 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.297309 0.527 0 0
Signaling by ERBB2 R-HSA-1227986 0.207660 0.683 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.363578 0.439 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.184357 0.734 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.467260 0.330 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.542147 0.266 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.440216 0.356 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.460642 0.337 0 0
Integration of provirus R-HSA-162592 0.111273 0.954 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.133711 0.874 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.467260 0.330 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.458833 0.338 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.494351 0.306 0 0
DNA Double Strand Break Response R-HSA-5693606 0.423440 0.373 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.408885 0.388 0 0
Frs2-mediated activation R-HSA-170968 0.609776 0.215 0 0
Oncogene Induced Senescence R-HSA-2559585 0.250320 0.602 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.179437 0.746 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.209962 0.678 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.273143 0.564 0 0
MAP2K and MAPK activation R-HSA-5674135 0.246719 0.608 0 0
Josephin domain DUBs R-HSA-5689877 0.466784 0.331 0 0
DARPP-32 events R-HSA-180024 0.417670 0.379 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.609776 0.215 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.595336 0.225 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.611797 0.213 0 0
Signaling by BMP R-HSA-201451 0.214107 0.669 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.383029 0.417 0 0
Generation of second messenger molecules R-HSA-202433 0.503756 0.298 0 0
EPH-Ephrin signaling R-HSA-2682334 0.120802 0.918 0 0
Signalling to ERKs R-HSA-187687 0.399147 0.399 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.149580 0.825 0 0
Signaling by FGFR4 R-HSA-5654743 0.280382 0.552 0 0
Muscarinic acetylcholine receptors R-HSA-390648 0.208423 0.681 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.181967 0.740 0 0
Regulation of CDH11 function R-HSA-9762292 0.466784 0.331 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.436073 0.360 0 0
Attenuation phase R-HSA-3371568 0.344205 0.463 0 0
Homology Directed Repair R-HSA-5693538 0.255685 0.592 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.505399 0.296 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.542147 0.266 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.576951 0.239 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 0.620539 0.207 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.553546 0.257 0 0
Signalling to RAS R-HSA-167044 0.609438 0.215 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.108000 0.967 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.149891 0.824 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.181288 0.742 0 0
Co-stimulation by CD28 R-HSA-389356 0.368687 0.433 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.490480 0.309 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.417670 0.379 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.574711 0.241 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.542147 0.266 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.360566 0.443 0 0
IGF1R signaling cascade R-HSA-2428924 0.170135 0.769 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.165075 0.782 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 0.297265 0.527 0 0
HSF1-dependent transactivation R-HSA-3371571 0.108709 0.964 1 1
Regulation of CDH1 Function R-HSA-9764561 0.102417 0.990 0 0
Sodium/Proton exchangers R-HSA-425986 0.384529 0.415 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 0.384529 0.415 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.138820 0.858 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.304736 0.516 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 0.426429 0.370 0 0
Unwinding of DNA R-HSA-176974 0.426429 0.370 0 0
Regulation of gap junction activity R-HSA-191650 0.516502 0.287 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.243025 0.614 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 0.571666 0.243 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.359642 0.444 0 0
NF-kB is activated and signals survival R-HSA-209560 0.542147 0.266 0 0
PKA activation R-HSA-163615 0.527144 0.278 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.502653 0.299 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 0.576951 0.239 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 0.620539 0.207 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.574711 0.241 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.589318 0.230 0 0
Signaling by PDGF R-HSA-186797 0.473829 0.324 0 0
G0 and Early G1 R-HSA-1538133 0.094946 1.023 0 0
Nuclear RNA decay R-HSA-9930044 0.198286 0.703 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.298678 0.525 1 1
CD209 (DC-SIGN) signaling R-HSA-5621575 0.299791 0.523 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.103323 0.986 0 0
Mitotic Anaphase R-HSA-68882 0.099129 1.004 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.576951 0.239 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.565977 0.247 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.616798 0.210 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.511302 0.291 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.195126 0.710 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.511302 0.291 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.553710 0.257 0 0
p75NTR signals via NF-kB R-HSA-193639 0.404224 0.393 0 0
Signaling by FGFR R-HSA-190236 0.559081 0.253 0 0
rRNA processing R-HSA-72312 0.417615 0.379 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.535895 0.271 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.535895 0.271 0 0
Cilium Assembly R-HSA-5617833 0.110341 0.957 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.303782 0.517 0 0
Mitotic Prophase R-HSA-68875 0.143940 0.842 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.349276 0.457 1 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.252749 0.597 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.110059 0.958 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.151149 0.821 0 0
Adrenoceptors R-HSA-390696 0.384529 0.415 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.276696 0.558 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.273143 0.564 0 0
IRS-mediated signalling R-HSA-112399 0.267250 0.573 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.335455 0.474 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 0.571666 0.243 0 0
Activation of AKT2 R-HSA-165158 0.571666 0.243 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.497653 0.303 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.497653 0.303 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.423440 0.373 0 0
Aggrephagy R-HSA-9646399 0.503756 0.298 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.576951 0.239 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.576951 0.239 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.563338 0.249 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.560649 0.251 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.578460 0.238 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.609438 0.215 0 0
RNA Polymerase II Transcription R-HSA-73857 0.331714 0.479 1 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.589424 0.230 0 0
Ub-specific processing proteases R-HSA-5689880 0.099479 1.002 0 0
Mismatch Repair R-HSA-5358508 0.304736 0.516 0 0
Ion homeostasis R-HSA-5578775 0.372548 0.429 1 1
Regulation of CDH11 Expression and Function R-HSA-9759475 0.253005 0.597 0 0
Signaling by SCF-KIT R-HSA-1433557 0.280382 0.552 0 0
Generic Transcription Pathway R-HSA-212436 0.615809 0.211 1 0
Signaling by ROBO receptors R-HSA-376176 0.183073 0.737 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.306411 0.514 0 0
Regulation of KIT signaling R-HSA-1433559 0.371870 0.430 0 0
Deubiquitination R-HSA-5688426 0.140038 0.854 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.198485 0.702 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.546249 0.263 0 0
DNA Repair R-HSA-73894 0.247594 0.606 0 0
CHL1 interactions R-HSA-447041 0.122844 0.911 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.341352 0.467 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 0.516502 0.287 0 0
HDACs deacetylate histones R-HSA-3214815 0.238227 0.623 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.439677 0.357 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.571666 0.243 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 0.620539 0.207 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 0.620539 0.207 0 0
S Phase R-HSA-69242 0.539271 0.268 0 0
Processing of SMDT1 R-HSA-8949664 0.609776 0.215 0 0
Opioid Signalling R-HSA-111885 0.237072 0.625 1 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.528254 0.277 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.528481 0.277 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.479775 0.319 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.485915 0.313 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.183188 0.737 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.335455 0.474 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.208423 0.681 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.113321 0.946 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.297265 0.527 0 0
ERK/MAPK targets R-HSA-198753 0.210152 0.677 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.384529 0.415 0 0
Rap1 signalling R-HSA-392517 0.331768 0.479 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.150262 0.823 0 0
Vesicle-mediated transport R-HSA-5653656 0.570904 0.243 0 0
HSF1 activation R-HSA-3371511 0.595336 0.225 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.616798 0.210 0 0
HIV Life Cycle R-HSA-162587 0.124999 0.903 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.252949 0.597 1 0
MAP kinase activation R-HSA-450294 0.457066 0.340 0 0
Signaling by FGFR3 R-HSA-5654741 0.460642 0.337 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.306411 0.514 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.377875 0.423 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.558917 0.253 0 0
Signal transduction by L1 R-HSA-445144 0.583095 0.234 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.502653 0.299 0 0
HDMs demethylate histones R-HSA-3214842 0.517201 0.286 0 0
Signaling by MET R-HSA-6806834 0.498735 0.302 0 0
Mitochondrial biogenesis R-HSA-1592230 0.620390 0.207 0 0
Signaling by FGFR1 R-HSA-5654736 0.372548 0.429 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.105802 0.976 0 0
Insulin receptor signalling cascade R-HSA-74751 0.375524 0.425 0 0
MTOR signalling R-HSA-165159 0.263391 0.579 0 0
Interleukin-17 signaling R-HSA-448424 0.601865 0.221 0 0
G2/M Transition R-HSA-69275 0.092391 1.034 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 0.304636 0.516 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 0.304636 0.516 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 0.304636 0.516 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.150277 0.823 1 1
Zinc influx into cells by the SLC39 gene family R-HSA-442380 0.179437 0.746 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 0.252749 0.597 0 0
Interleukin-33 signaling R-HSA-9014843 0.383959 0.416 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.383959 0.416 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 0.383959 0.416 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.153514 0.814 0 0
Signaling by AXIN mutants R-HSA-4839735 0.273760 0.563 0 0
MET interacts with TNS proteins R-HSA-8875513 0.454237 0.343 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 0.454237 0.343 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 0.384529 0.415 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.233302 0.632 1 1
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.339195 0.470 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.113739 0.944 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.299791 0.523 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 0.516502 0.287 0 0
PI3K Cascade R-HSA-109704 0.273752 0.563 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.101105 0.995 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.170859 0.767 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.315160 0.501 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.294962 0.530 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.377875 0.423 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.467260 0.330 0 0
Bicarbonate transporters R-HSA-425381 0.505399 0.296 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 0.505399 0.296 0 0
Reelin signalling pathway R-HSA-8866376 0.571666 0.243 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.441506 0.355 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.457066 0.340 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.527144 0.278 0 0
PKA activation in glucagon signalling R-HSA-164378 0.527144 0.278 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.437912 0.359 0 0
Gene Silencing by RNA R-HSA-211000 0.473131 0.325 0 0
Phosphorylation of Emi1 R-HSA-176417 0.620539 0.207 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.620539 0.207 0 0
Synthesis of PS R-HSA-1483101 0.620539 0.207 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.513559 0.289 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 0.609776 0.215 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 0.609776 0.215 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.611904 0.213 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.615390 0.211 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.375175 0.426 0 0
Cell junction organization R-HSA-446728 0.225428 0.647 0 0
HIV Infection R-HSA-162906 0.445102 0.352 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.089056 1.050 0 0
ESR-mediated signaling R-HSA-8939211 0.604892 0.218 0 0
Selective autophagy R-HSA-9663891 0.291593 0.535 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.216142 0.665 0 0
GPVI-mediated activation cascade R-HSA-114604 0.268522 0.571 0 0
Cell-cell junction organization R-HSA-421270 0.441087 0.355 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.370410 0.431 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.466485 0.331 0 0
Adherens junctions interactions R-HSA-418990 0.437488 0.359 0 0
Regulation of TP53 Activity R-HSA-5633007 0.102234 0.990 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.243036 0.614 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.243036 0.614 0 0
HATs acetylate histones R-HSA-3214847 0.264882 0.577 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.177518 0.751 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.231772 0.635 0 0
Rab regulation of trafficking R-HSA-9007101 0.327536 0.485 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.436073 0.360 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.359642 0.444 0 0
Signaling by PTK6 R-HSA-8848021 0.359642 0.444 0 0
Muscle contraction R-HSA-397014 0.315102 0.502 1 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.252596 0.598 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.276696 0.558 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.131691 0.880 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.497653 0.303 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.169467 0.771 0 0
Signaling by TGFB family members R-HSA-9006936 0.326289 0.486 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.417670 0.379 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.115342 0.938 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.179437 0.746 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.297265 0.527 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.426429 0.370 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.335455 0.474 0 0
Signal attenuation R-HSA-74749 0.466784 0.331 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.230381 0.638 0 0
tRNA processing in the nucleus R-HSA-6784531 0.343852 0.464 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 0.467260 0.330 0 0
TRP channels R-HSA-3295583 0.541922 0.266 0 0
Regulation of signaling by CBL R-HSA-912631 0.555647 0.255 0 0
TBC/RABGAPs R-HSA-8854214 0.582430 0.235 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 0.609438 0.215 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.611904 0.213 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.501954 0.299 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.121309 0.916 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.128105 0.892 0 0
Signaling by NTRKs R-HSA-166520 0.286495 0.543 0 0
Negative regulation of MET activity R-HSA-6807004 0.189231 0.723 0 0
G2/M Checkpoints R-HSA-69481 0.454882 0.342 0 0
Pyroptosis R-HSA-5620971 0.589318 0.230 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 0.609438 0.215 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.314440 0.502 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.252749 0.597 0 0
Signal regulatory protein family interactions R-HSA-391160 0.176585 0.753 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.117314 0.931 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.341352 0.467 0 0
Signaling by LTK R-HSA-9842663 0.306411 0.514 0 0
Mitochondrial calcium ion transport R-HSA-8949215 0.231772 0.635 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.277959 0.556 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.198286 0.703 0 0
Interleukin-1 processing R-HSA-448706 0.426429 0.370 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.462479 0.335 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 0.620539 0.207 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 0.620539 0.207 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.619282 0.208 0 0
FLT3 Signaling R-HSA-9607240 0.523967 0.281 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.253988 0.595 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.554064 0.256 0 0
Programmed Cell Death R-HSA-5357801 0.202864 0.693 0 0
Signaling by KIT in disease R-HSA-9669938 0.439677 0.357 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.102417 0.990 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.580561 0.236 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 0.436073 0.360 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.356623 0.448 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.412982 0.384 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.483245 0.316 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.527144 0.278 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.209962 0.678 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.347778 0.459 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.579617 0.237 0 0
Cellular responses to stress R-HSA-2262752 0.185314 0.732 1 0
Ion transport by P-type ATPases R-HSA-936837 0.375524 0.425 1 1
Cellular responses to stimuli R-HSA-8953897 0.259307 0.586 1 0
Regulation of beta-cell development R-HSA-186712 0.297309 0.527 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.214107 0.669 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.582430 0.235 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.108700 0.964 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.304636 0.516 0 0
Diseases of cellular response to stress R-HSA-9675132 0.383959 0.416 0 0
Diseases of Cellular Senescence R-HSA-9630747 0.383959 0.416 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 0.297265 0.527 0 0
Synthesis of PI R-HSA-1483226 0.241511 0.617 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.225793 0.646 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 0.454237 0.343 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.111408 0.953 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.210152 0.677 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.339195 0.470 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 0.339195 0.470 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.426429 0.370 0 0
NADE modulates death signalling R-HSA-205025 0.516502 0.287 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.335455 0.474 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.370410 0.431 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.467260 0.330 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 0.505399 0.296 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.505399 0.296 0 0
Interleukin-36 pathway R-HSA-9014826 0.571666 0.243 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 0.571666 0.243 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 0.542147 0.266 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.509747 0.293 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.502653 0.299 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 0.620539 0.207 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.609438 0.215 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.589424 0.230 0 0
Smooth Muscle Contraction R-HSA-445355 0.606567 0.217 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.179437 0.746 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.113321 0.946 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.420377 0.376 0 0
Apoptosis R-HSA-109581 0.112314 0.950 0 0
Nuclear import of Rev protein R-HSA-180746 0.129466 0.888 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.318139 0.497 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.399147 0.399 0 0
Suppression of apoptosis R-HSA-9635465 0.505399 0.296 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.565977 0.247 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.541922 0.266 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.497653 0.303 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.157826 0.802 0 0
PI Metabolism R-HSA-1483255 0.216684 0.664 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.509747 0.293 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 0.252749 0.597 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 0.383959 0.416 0 0
Signaling by LTK in cancer R-HSA-9842640 0.297265 0.527 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.200734 0.697 0 0
Interleukin-18 signaling R-HSA-9012546 0.384529 0.415 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.214500 0.669 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.230409 0.638 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.426429 0.370 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.426429 0.370 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 0.516502 0.287 0 0
Dopamine receptors R-HSA-390651 0.516502 0.287 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 0.466784 0.331 0 0
NrCAM interactions R-HSA-447038 0.571666 0.243 0 0
Co-inhibition by BTLA R-HSA-9927353 0.571666 0.243 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.542147 0.266 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 0.620539 0.207 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.308749 0.510 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.583095 0.234 0 0
Nephron development R-HSA-9831926 0.304736 0.516 0 0
Zinc transporters R-HSA-435354 0.371870 0.430 0 0
Sensory processing of sound R-HSA-9659379 0.483801 0.315 0 0
Signaling by ALK R-HSA-201556 0.483245 0.316 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.615390 0.211 0 0
Inositol phosphate metabolism R-HSA-1483249 0.536370 0.271 0 0
Diseases of DNA repair R-HSA-9675135 0.479775 0.319 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.252749 0.597 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.176585 0.753 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 0.341352 0.467 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.384529 0.415 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.184035 0.735 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.339195 0.470 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 0.426429 0.370 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.426429 0.370 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.332863 0.478 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.571666 0.243 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.620539 0.207 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.589424 0.230 0 0
Influenza Infection R-HSA-168255 0.607458 0.216 0 0
Apoptotic factor-mediated response R-HSA-111471 0.527144 0.278 0 0
Other interleukin signaling R-HSA-449836 0.555647 0.255 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.367347 0.435 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.439677 0.357 0 0
Tie2 Signaling R-HSA-210993 0.527144 0.278 0 0
IRE1alpha activates chaperones R-HSA-381070 0.450476 0.346 0 0
Interleukin-12 signaling R-HSA-9020591 0.147831 0.830 0 0
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 0.516502 0.287 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.252596 0.598 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 0.571666 0.243 0 0
Interleukin-2 family signaling R-HSA-451927 0.503756 0.298 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.609438 0.215 0 0
Signaling by Leptin R-HSA-2586552 0.466784 0.331 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.620539 0.207 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 0.576951 0.239 0 0
Interleukin-37 signaling R-HSA-9008059 0.273143 0.564 0 0
Interleukin-12 family signaling R-HSA-447115 0.279168 0.554 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.621591 0.206 0 0
Signaling by FGFR2 R-HSA-5654738 0.621591 0.206 0 0
Autophagy R-HSA-9612973 0.622472 0.206 0 0
Peptide chain elongation R-HSA-156902 0.626195 0.203 0 0
Diseases of programmed cell death R-HSA-9645723 0.626195 0.203 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.630628 0.200 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.631437 0.200 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.631437 0.200 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.633705 0.198 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.633705 0.198 0 0
Activation of BH3-only proteins R-HSA-114452 0.633705 0.198 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.634644 0.197 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.634644 0.197 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.634847 0.197 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.634905 0.197 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.640621 0.193 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 0.640621 0.193 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.640621 0.193 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.640621 0.193 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 0.640621 0.193 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.640621 0.193 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.643146 0.192 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.643146 0.192 0 0
Potential therapeutics for SARS R-HSA-9679191 0.648095 0.188 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.648435 0.188 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.653688 0.185 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.653688 0.185 0 0
TNF signaling R-HSA-75893 0.655614 0.183 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.655614 0.183 0 0
Nucleotide Excision Repair R-HSA-5696398 0.658650 0.181 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.658692 0.181 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.658692 0.181 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.658692 0.181 0 0
FGFR2 alternative splicing R-HSA-6803529 0.658692 0.181 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.658692 0.181 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.661835 0.179 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 0.663839 0.178 0 0
VLDL assembly R-HSA-8866423 0.663839 0.178 0 0
Chylomicron clearance R-HSA-8964026 0.663839 0.178 0 0
STAT5 Activation R-HSA-9645135 0.663839 0.178 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.663839 0.178 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 0.663839 0.178 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 0.663839 0.178 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 0.663839 0.178 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 0.663839 0.178 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 0.663839 0.178 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 0.663839 0.178 0 0
Agmatine biosynthesis R-HSA-351143 0.663839 0.178 0 0
Neurofascin interactions R-HSA-447043 0.663839 0.178 0 0
Nef and signal transduction R-HSA-164944 0.663839 0.178 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.664826 0.177 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.667490 0.176 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.667595 0.175 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.669510 0.174 0 0
Erythropoietin activates RAS R-HSA-9027284 0.669510 0.174 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.669510 0.174 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.669510 0.174 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.669510 0.174 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 0.669510 0.174 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.669510 0.174 0 0
p38MAPK events R-HSA-171007 0.669510 0.174 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.669510 0.174 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.669510 0.174 0 0
Protein methylation R-HSA-8876725 0.669510 0.174 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.669510 0.174 0 0
DNA Damage Reversal R-HSA-73942 0.669510 0.174 0 0
Metal ion SLC transporters R-HSA-425410 0.670920 0.173 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.671895 0.173 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.671895 0.173 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.673476 0.172 0 0
DNA strand elongation R-HSA-69190 0.674867 0.171 0 0
Signaling by WNT in cancer R-HSA-4791275 0.674867 0.171 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.681528 0.167 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.681575 0.166 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.681575 0.166 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.681575 0.166 0 0
Syndecan interactions R-HSA-3000170 0.681575 0.166 0 0
Growth hormone receptor signaling R-HSA-982772 0.681575 0.166 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.687101 0.163 0 0
Degradation of CDH1 R-HSA-9766229 0.687101 0.163 0 0
Meiosis R-HSA-1500620 0.687897 0.162 0 0
Signaling by Insulin receptor R-HSA-74752 0.689272 0.162 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.689459 0.161 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.689459 0.161 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.689459 0.161 0 0
Glycolysis R-HSA-70171 0.690869 0.161 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.692628 0.160 0 0
G-protein beta:gamma signalling R-HSA-397795 0.694204 0.159 0 0
Integrin signaling R-HSA-354192 0.694204 0.159 0 0
Host Interactions of HIV factors R-HSA-162909 0.696471 0.157 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.696489 0.157 0 0
Killing mechanisms R-HSA-9664420 0.696489 0.157 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.696489 0.157 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.696489 0.157 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 0.696489 0.157 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 0.696489 0.157 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.696489 0.157 0 0
Adipogenesis R-HSA-9843745 0.698499 0.156 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.702182 0.154 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.702199 0.154 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.702199 0.154 0 0
Recycling of eIF2:GDP R-HSA-72731 0.702199 0.154 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 0.702199 0.154 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 0.702199 0.154 0 0
LDL remodeling R-HSA-8964041 0.702199 0.154 0 0
PTK6 Expression R-HSA-8849473 0.702199 0.154 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.702199 0.154 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 0.702199 0.154 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 0.702199 0.154 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 0.702199 0.154 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.702199 0.154 0 0
Glycoprotein hormones R-HSA-209822 0.702199 0.154 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 0.702199 0.154 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 0.702199 0.154 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.702199 0.154 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 0.702199 0.154 0 0
Signaling by Interleukins R-HSA-449147 0.703005 0.153 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.703295 0.153 0 0
Complex III assembly R-HSA-9865881 0.703295 0.153 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.703295 0.153 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.703495 0.153 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.713304 0.147 0 0
Neutrophil degranulation R-HSA-6798695 0.716021 0.145 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.717835 0.144 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.719305 0.143 0 0
Macroautophagy R-HSA-1632852 0.719305 0.143 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.721616 0.142 0 0
Passive transport by Aquaporins R-HSA-432047 0.721616 0.142 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.722628 0.141 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.723858 0.140 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 0.723864 0.140 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.723864 0.140 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.723864 0.140 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.723864 0.140 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.723864 0.140 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.725810 0.139 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.726263 0.139 0 0
Dual Incision in GG-NER R-HSA-5696400 0.730371 0.136 0 0
Mitophagy R-HSA-5205647 0.730371 0.136 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.730371 0.136 0 0
Transmission across Chemical Synapses R-HSA-112315 0.731674 0.136 1 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.732434 0.135 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.734565 0.134 0 0
Eukaryotic Translation Termination R-HSA-72764 0.734814 0.134 0 0
phospho-PLA2 pathway R-HSA-111995 0.736184 0.133 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.736184 0.133 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 0.736184 0.133 0 0
MET receptor recycling R-HSA-8875656 0.736184 0.133 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.736184 0.133 0 0
Activation of RAS in B cells R-HSA-1169092 0.736184 0.133 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 0.736184 0.133 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 0.736184 0.133 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 0.736184 0.133 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 0.736184 0.133 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.736184 0.133 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.736780 0.133 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.736780 0.133 0 0
PKR-mediated signaling R-HSA-9833482 0.736780 0.133 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.738335 0.132 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.738821 0.131 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.743302 0.129 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.743302 0.129 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.743302 0.129 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.743302 0.129 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.744564 0.128 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.744962 0.128 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.744962 0.128 0 0
Specification of primordial germ cells R-HSA-9827857 0.744962 0.128 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.746465 0.127 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.746465 0.127 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.747210 0.127 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.750976 0.124 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.751672 0.124 0 0
DAP12 interactions R-HSA-2172127 0.753178 0.123 0 0
RMTs methylate histone arginines R-HSA-3214858 0.753178 0.123 0 0
Amine ligand-binding receptors R-HSA-375280 0.753178 0.123 0 0
Translation initiation complex formation R-HSA-72649 0.759956 0.119 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.761633 0.118 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.761633 0.118 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.761633 0.118 0 0
Insulin processing R-HSA-264876 0.761633 0.118 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.762729 0.118 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.763232 0.117 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.763232 0.117 0 0
Ion channel transport R-HSA-983712 0.765769 0.116 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.765936 0.116 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.765936 0.116 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.765936 0.116 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 0.766293 0.116 0 0
WNT mediated activation of DVL R-HSA-201688 0.766293 0.116 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 0.766293 0.116 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 0.766293 0.116 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.766293 0.116 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.766293 0.116 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.766293 0.116 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.766293 0.116 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.766608 0.115 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.766608 0.115 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.767480 0.115 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.767480 0.115 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.767870 0.115 0 0
Neuronal System R-HSA-112316 0.772010 0.112 1 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.772787 0.112 0 0
Signaling by NOTCH3 R-HSA-9012852 0.772911 0.112 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.778886 0.109 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.778886 0.109 0 0
PTEN Regulation R-HSA-6807070 0.779288 0.108 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.779288 0.108 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.782644 0.106 0 0
Stimuli-sensing channels R-HSA-2672351 0.783214 0.106 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.785030 0.105 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.785336 0.105 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.785336 0.105 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.785336 0.105 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.786637 0.104 0 0
Specification of the neural plate border R-HSA-9834899 0.786637 0.104 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.786637 0.104 0 0
The NLRP3 inflammasome R-HSA-844456 0.786637 0.104 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.786637 0.104 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.786637 0.104 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.787985 0.103 0 0
MET promotes cell motility R-HSA-8875878 0.792886 0.101 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.792967 0.101 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.792967 0.101 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 0.792967 0.101 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 0.792967 0.101 0 0
Peptide hormone biosynthesis R-HSA-209952 0.792967 0.101 0 0
Selenocysteine synthesis R-HSA-2408557 0.794426 0.100 0 0
mRNA Capping R-HSA-72086 0.795098 0.100 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.795098 0.100 0 0
Platelet calcium homeostasis R-HSA-418360 0.795098 0.100 0 0
Glucose metabolism R-HSA-70326 0.798777 0.098 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.805136 0.094 0 0
Co-inhibition by CTLA4 R-HSA-389513 0.805136 0.094 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 0.805136 0.094 0 0
Glycogen synthesis R-HSA-3322077 0.805136 0.094 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 0.805136 0.094 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.805747 0.094 0 0
Intraflagellar transport R-HSA-5620924 0.806595 0.093 0 0
NGF-stimulated transcription R-HSA-9031628 0.806595 0.093 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.808622 0.092 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.809962 0.092 0 0
Activation of the pre-replicative complex R-HSA-68962 0.810304 0.091 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.810304 0.091 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.810304 0.091 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 0.810304 0.091 0 0
Viral mRNA Translation R-HSA-192823 0.811969 0.090 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.816598 0.088 0 0
Chylomicron assembly R-HSA-8963888 0.816598 0.088 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.816598 0.088 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 0.816598 0.088 0 0
vRNP Assembly R-HSA-192905 0.816598 0.088 0 0
vRNA Synthesis R-HSA-192814 0.816598 0.088 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.816598 0.088 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 0.816598 0.088 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 0.816598 0.088 0 0
Transport of RCbl within the body R-HSA-9758890 0.816598 0.088 0 0
Interleukin-2 signaling R-HSA-9020558 0.816598 0.088 0 0
Dissolution of Fibrin Clot R-HSA-75205 0.816598 0.088 0 0
DNA Damage Bypass R-HSA-73893 0.818410 0.087 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.819479 0.086 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.819479 0.086 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.819479 0.086 0 0
Glycogen metabolism R-HSA-8982491 0.819479 0.086 0 0
Lagging Strand Synthesis R-HSA-69186 0.822193 0.085 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.822193 0.085 0 0
Basigin interactions R-HSA-210991 0.822193 0.085 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 0.822193 0.085 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.824545 0.084 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 0.824545 0.084 0 0
Cargo concentration in the ER R-HSA-5694530 0.824545 0.084 0 0
Budding and maturation of HIV virion R-HSA-162588 0.824545 0.084 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.829885 0.081 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.829885 0.081 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.829885 0.081 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.829885 0.081 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.829885 0.081 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.829997 0.081 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.831491 0.080 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.831491 0.080 0 0
COPII-mediated vesicle transport R-HSA-204005 0.831491 0.080 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.836880 0.077 0 0
Scavenging by Class H Receptors R-HSA-3000497 0.837533 0.077 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 0.837533 0.077 0 0
ERKs are inactivated R-HSA-202670 0.837533 0.077 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.837533 0.077 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 0.837533 0.077 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.837533 0.077 0 0
Sodium/Calcium exchangers R-HSA-425561 0.837533 0.077 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.837897 0.077 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.837897 0.077 0 0
Assembly Of The HIV Virion R-HSA-175474 0.837897 0.077 0 0
Ribosome-associated quality control R-HSA-9948299 0.839324 0.076 0 0
Aquaporin-mediated transport R-HSA-445717 0.839786 0.076 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.840158 0.076 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.840727 0.075 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.840727 0.075 0 0
Hedgehog 'on' state R-HSA-5632684 0.840727 0.075 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.843191 0.074 0 0
HIV Transcription Initiation R-HSA-167161 0.843191 0.074 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.843191 0.074 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.843191 0.074 0 0
Intra-Golgi traffic R-HSA-6811438 0.843191 0.074 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.843668 0.074 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.844174 0.074 0 0
Downstream TCR signaling R-HSA-202424 0.845022 0.073 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.847264 0.072 0 0
Cardiac conduction R-HSA-5576891 0.848169 0.072 1 0
Mitochondrial protein import R-HSA-1268020 0.849215 0.071 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.849215 0.071 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.850009 0.071 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.850295 0.070 0 0
Leishmania phagocytosis R-HSA-9664417 0.852120 0.069 0 0
Parasite infection R-HSA-9664407 0.852120 0.069 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.852120 0.069 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 0.852333 0.069 0 0
LDL clearance R-HSA-8964038 0.852333 0.069 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.852333 0.069 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.854029 0.069 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.854029 0.069 0 0
FOXO-mediated transcription R-HSA-9614085 0.855213 0.068 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 0.856079 0.067 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 0.856079 0.067 0 0
IRAK1 recruits IKK complex R-HSA-937039 0.856079 0.067 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 0.856079 0.067 0 0
Maple Syrup Urine Disease R-HSA-9865114 0.856079 0.067 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.856079 0.067 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.856079 0.067 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 0.856079 0.067 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 0.856079 0.067 0 0
MET activates RAS signaling R-HSA-8851805 0.856079 0.067 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 0.856079 0.067 0 0
Polymerase switching R-HSA-69091 0.856079 0.067 0 0
Leading Strand Synthesis R-HSA-69109 0.856079 0.067 0 0
Regulation of IFNG signaling R-HSA-877312 0.856079 0.067 0 0
Estrogen biosynthesis R-HSA-193144 0.856079 0.067 0 0
Interleukin-15 signaling R-HSA-8983432 0.856079 0.067 0 0
OAS antiviral response R-HSA-8983711 0.856079 0.067 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.858805 0.066 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.859805 0.066 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.859959 0.066 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.859959 0.066 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.861889 0.065 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.861889 0.065 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.861889 0.065 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.861889 0.065 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.861889 0.065 0 0
Hedgehog 'off' state R-HSA-5610787 0.862298 0.064 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.863714 0.064 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.863714 0.064 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.863714 0.064 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.864224 0.063 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.865587 0.063 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.865587 0.063 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.865587 0.063 0 0
Signaling by ERBB4 R-HSA-1236394 0.866021 0.062 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.869006 0.061 0 0
FGFR4 ligand binding and activation R-HSA-190322 0.872509 0.059 0 0
Chylomicron remodeling R-HSA-8963901 0.872509 0.059 0 0
CD28 dependent Vav1 pathway R-HSA-389359 0.872509 0.059 0 0
Formation of axial mesoderm R-HSA-9796292 0.872509 0.059 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.872509 0.059 0 0
rRNA modification in the mitochondrion R-HSA-6793080 0.872509 0.059 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 0.872509 0.059 0 0
eNOS activation R-HSA-203615 0.872686 0.059 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.872686 0.059 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.872686 0.059 0 0
Interleukin-1 family signaling R-HSA-446652 0.872905 0.059 0 0
Protein ubiquitination R-HSA-8852135 0.873683 0.059 0 0
Platelet degranulation R-HSA-114608 0.875634 0.058 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.877554 0.057 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 0.877741 0.057 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 0.877741 0.057 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.877741 0.057 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.879177 0.056 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.879177 0.056 0 0
Signaling by NOTCH1 R-HSA-1980143 0.880978 0.055 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.882487 0.054 0 0
PERK regulates gene expression R-HSA-381042 0.882730 0.054 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.882791 0.054 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.882791 0.054 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.882791 0.054 0 0
Integration of energy metabolism R-HSA-163685 0.883504 0.054 0 0
Removal of the Flap Intermediate R-HSA-69166 0.887064 0.052 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 0.887064 0.052 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 0.887064 0.052 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.887064 0.052 0 0
Hydrolysis of LPC R-HSA-1483115 0.887064 0.052 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 0.887064 0.052 0 0
cGMP effects R-HSA-418457 0.887064 0.052 0 0
Physiological factors R-HSA-5578768 0.887064 0.052 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 0.887064 0.052 0 0
Acyl chain remodeling of CL R-HSA-1482798 0.887064 0.052 0 0
PPARA activates gene expression R-HSA-1989781 0.888201 0.051 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.888697 0.051 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.888873 0.051 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.888873 0.051 0 0
Chromosome Maintenance R-HSA-73886 0.890340 0.050 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.890792 0.050 0 0
Interferon Signaling R-HSA-913531 0.891146 0.050 1 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.891217 0.050 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.891217 0.050 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.891217 0.050 0 0
Signaling by TGFBR3 R-HSA-9839373 0.891217 0.050 0 0
Signaling by Hedgehog R-HSA-5358351 0.893701 0.049 0 0
PCP/CE pathway R-HSA-4086400 0.894516 0.048 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.895598 0.048 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.895598 0.048 0 0
Regulated Necrosis R-HSA-5218859 0.896657 0.047 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.896657 0.047 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.897554 0.047 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.899057 0.046 0 0
Myogenesis R-HSA-525793 0.899057 0.046 0 0
Sphingolipid catabolism R-HSA-9845614 0.899057 0.046 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.899057 0.046 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.899107 0.046 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.899107 0.046 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.899107 0.046 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.899107 0.046 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.899959 0.046 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.899959 0.046 0 0
Translesion synthesis by REV1 R-HSA-110312 0.899959 0.046 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.899959 0.046 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.899959 0.046 0 0
Protein lipoylation R-HSA-9857492 0.899959 0.046 0 0
Dual incision in TC-NER R-HSA-6782135 0.900396 0.046 0 0
Platelet homeostasis R-HSA-418346 0.904431 0.044 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.907141 0.042 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 0.908365 0.042 0 0
Cristae formation R-HSA-8949613 0.908365 0.042 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.908365 0.042 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.908746 0.042 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.909338 0.041 0 0
Synthesis of DNA R-HSA-69239 0.909466 0.041 0 0
Translesion synthesis by POLI R-HSA-5656121 0.911381 0.040 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 0.911381 0.040 0 0
Phase 4 - resting membrane potential R-HSA-5576886 0.911381 0.040 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 0.911381 0.040 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 0.911381 0.040 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.911381 0.040 0 0
Differentiation of T cells R-HSA-9945266 0.911381 0.040 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 0.911381 0.040 0 0
Activation of SMO R-HSA-5635838 0.911381 0.040 0 0
Negative regulation of FLT3 R-HSA-9706369 0.911381 0.040 0 0
Atorvastatin ADME R-HSA-9754706 0.911381 0.040 0 0
Gap junction trafficking and regulation R-HSA-157858 0.913386 0.039 0 0
Kinesins R-HSA-983189 0.913483 0.039 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.915157 0.039 0 0
Stabilization of p53 R-HSA-69541 0.916180 0.038 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.916180 0.038 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.916180 0.038 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.916864 0.038 0 0
Inflammasomes R-HSA-622312 0.916864 0.038 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.916864 0.038 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.921501 0.036 0 0
Translesion synthesis by POLK R-HSA-5655862 0.921501 0.036 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.921501 0.036 0 0
Scavenging by Class B Receptors R-HSA-3000471 0.921501 0.036 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 0.921501 0.036 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.921501 0.036 0 0
Phase 2 - plateau phase R-HSA-5576893 0.921501 0.036 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.921501 0.036 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 0.921501 0.036 0 0
Galactose catabolism R-HSA-70370 0.921501 0.036 0 0
Coenzyme A biosynthesis R-HSA-196783 0.921501 0.036 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 0.921501 0.036 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.921861 0.035 0 0
Diseases of Immune System R-HSA-5260271 0.923057 0.035 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.923057 0.035 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.923057 0.035 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.924618 0.034 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.925034 0.034 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.925034 0.034 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.925834 0.033 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.926691 0.033 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.928349 0.032 1 0
Cellular response to chemical stress R-HSA-9711123 0.928540 0.032 0 0
Maturation of spike protein R-HSA-9694548 0.929414 0.032 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.929836 0.032 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 0.930465 0.031 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 0.930465 0.031 0 0
Glycogen storage diseases R-HSA-3229121 0.930465 0.031 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 0.930465 0.031 0 0
Choline catabolism R-HSA-6798163 0.930465 0.031 0 0
Signaling by NOTCH4 R-HSA-9013694 0.930704 0.031 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.931433 0.031 0 0
Orc1 removal from chromatin R-HSA-68949 0.931433 0.031 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.933144 0.030 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.935195 0.029 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.935285 0.029 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.935285 0.029 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.935285 0.029 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.936354 0.029 0 0
Reproduction R-HSA-1474165 0.937600 0.028 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.937818 0.028 0 0
Cellular response to starvation R-HSA-9711097 0.937818 0.028 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.938123 0.028 0 0
Molecules associated with elastic fibres R-HSA-2129379 0.938123 0.028 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.938123 0.028 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 0.938406 0.028 0 0
Presynaptic function of Kainate receptors R-HSA-500657 0.938406 0.028 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 0.938406 0.028 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 0.938406 0.028 0 0
UCH proteinases R-HSA-5689603 0.939617 0.027 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.939617 0.027 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.940702 0.027 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.941498 0.026 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.944197 0.025 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.945324 0.024 0 0
Translesion Synthesis by POLH R-HSA-110320 0.945440 0.024 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 0.945440 0.024 0 0
Diseases of hemostasis R-HSA-9671793 0.945440 0.024 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.945440 0.024 0 0
Maturation of nucleoprotein R-HSA-9694631 0.945440 0.024 0 0
Paracetamol ADME R-HSA-9753281 0.946007 0.024 0 0
G alpha (z) signalling events R-HSA-418597 0.946007 0.024 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.947493 0.023 0 0
RNA Polymerase I Transcription R-HSA-73864 0.947493 0.023 0 0
Integrin cell surface interactions R-HSA-216083 0.947493 0.023 0 0
Interleukin-10 signaling R-HSA-6783783 0.947493 0.023 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.948127 0.023 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.949309 0.023 0 0
Cardiogenesis R-HSA-9733709 0.949309 0.023 0 0
Toll-like Receptor Cascades R-HSA-168898 0.949735 0.022 0 0
G1 Phase R-HSA-69236 0.950296 0.022 0 0
Cyclin D associated events in G1 R-HSA-69231 0.950296 0.022 0 0
Proteasome assembly R-HSA-9907900 0.950296 0.022 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.950296 0.022 0 0
Gap junction trafficking R-HSA-190828 0.950296 0.022 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 0.951672 0.022 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.951672 0.022 0 0
Pregnenolone biosynthesis R-HSA-196108 0.951672 0.022 0 0
Acyl chain remodelling of PI R-HSA-1482922 0.951672 0.022 0 0
Creatine metabolism R-HSA-71288 0.951672 0.022 0 0
Protein hydroxylation R-HSA-9629569 0.951672 0.022 0 0
Signaling by NODAL R-HSA-1181150 0.951672 0.022 0 0
Regulation of insulin secretion R-HSA-422356 0.951869 0.021 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.954151 0.020 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 0.954151 0.020 0 0
Heme degradation R-HSA-189483 0.954151 0.020 0 0
Somitogenesis R-HSA-9824272 0.954531 0.020 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.954531 0.020 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.957192 0.019 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 0.957192 0.019 0 0
G-protein activation R-HSA-202040 0.957192 0.019 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 0.957192 0.019 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.957192 0.019 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 0.957192 0.019 0 0
Acyl chain remodelling of PG R-HSA-1482925 0.957192 0.019 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.957693 0.019 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.958426 0.018 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.958426 0.018 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.958426 0.018 0 0
Signaling by NOTCH2 R-HSA-1980145 0.958548 0.018 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 0.958548 0.018 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.958548 0.018 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.958548 0.018 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.958548 0.018 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.958548 0.018 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.958675 0.018 0 0
Interleukin-1 signaling R-HSA-9020702 0.960381 0.018 0 0
HCMV Early Events R-HSA-9609690 0.960440 0.018 0 0
Extension of Telomeres R-HSA-180786 0.961037 0.017 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.962082 0.017 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.962082 0.017 0 0
Attachment and Entry R-HSA-9694614 0.962082 0.017 0 0
Glutathione synthesis and recycling R-HSA-174403 0.962082 0.017 0 0
Acyl chain remodelling of PE R-HSA-1482839 0.962540 0.017 0 0
Protein folding R-HSA-391251 0.962818 0.016 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.963916 0.016 0 0
tRNA Aminoacylation R-HSA-379724 0.964134 0.016 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.964134 0.016 0 0
GPER1 signaling R-HSA-9634597 0.965295 0.015 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.965307 0.015 0 0
G1/S-Specific Transcription R-HSA-69205 0.966161 0.015 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.966161 0.015 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 0.966413 0.015 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 0.966413 0.015 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 0.966413 0.015 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 0.966413 0.015 0 0
Ethanol oxidation R-HSA-71384 0.966413 0.015 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 0.966413 0.015 0 0
Cellular hexose transport R-HSA-189200 0.966413 0.015 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 0.966413 0.015 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.967001 0.015 0 0
Ca2+ pathway R-HSA-4086398 0.967224 0.014 0 0
Mitochondrial protein degradation R-HSA-9837999 0.967642 0.014 0 0
Signaling by NOTCH R-HSA-157118 0.969353 0.014 0 0
Degradation of DVL R-HSA-4641258 0.969443 0.013 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.969443 0.013 0 0
RSV-host interactions R-HSA-9833110 0.969620 0.013 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.970250 0.013 0 0
Carnitine shuttle R-HSA-200425 0.970250 0.013 0 0
Biosynthesis of maresins R-HSA-9018682 0.970250 0.013 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.971346 0.013 0 0
Parasitic Infection Pathways R-HSA-9824443 0.971664 0.012 0 0
Leishmania infection R-HSA-9658195 0.971664 0.012 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.972418 0.012 0 0
Elastic fibre formation R-HSA-1566948 0.972418 0.012 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.972492 0.012 0 0
Selenoamino acid metabolism R-HSA-2408522 0.973345 0.012 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.973623 0.012 0 0
Meiotic recombination R-HSA-912446 0.973623 0.012 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.973623 0.012 0 0
Plasma lipoprotein assembly R-HSA-8963898 0.973649 0.012 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.973649 0.012 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.973649 0.012 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.973649 0.012 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 0.973649 0.012 0 0
Interleukin-6 family signaling R-HSA-6783589 0.973649 0.012 0 0
G1/S Transition R-HSA-69206 0.973715 0.012 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.973815 0.012 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.974370 0.011 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.975112 0.011 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.975949 0.011 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.975949 0.011 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.976660 0.010 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 0.976660 0.010 0 0
Laminin interactions R-HSA-3000157 0.976660 0.010 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.977149 0.010 0 0
rRNA processing in the mitochondrion R-HSA-8868766 0.977550 0.010 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.977550 0.010 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.978080 0.010 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.978393 0.009 0 0
MET activates PTK2 signaling R-HSA-8874081 0.979327 0.009 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 0.979327 0.009 0 0
Metalloprotease DUBs R-HSA-5689901 0.979327 0.009 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.979327 0.009 0 0
Urea cycle R-HSA-70635 0.979327 0.009 0 0
Signaling by WNT R-HSA-195721 0.979425 0.009 0 0
Neurotransmitter release cycle R-HSA-112310 0.979786 0.009 0 0
Kidney development R-HSA-9830369 0.980173 0.009 0 0
ABC-family proteins mediated transport R-HSA-382556 0.980367 0.009 0 0
Co-inhibition by PD-1 R-HSA-389948 0.980813 0.008 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 0.981689 0.008 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.981689 0.008 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 0.981689 0.008 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.981752 0.008 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.981752 0.008 0 0
tRNA processing R-HSA-72306 0.982114 0.008 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.983444 0.007 0 0
Developmental Cell Lineages R-HSA-9734767 0.983541 0.007 0 0
Telomere Extension By Telomerase R-HSA-171319 0.983781 0.007 0 0
Insulin receptor recycling R-HSA-77387 0.983781 0.007 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.983781 0.007 0 0
Iron assimilation using enterobactin R-HSA-9638334 0.983781 0.007 0 0
Developmental Biology R-HSA-1266738 0.984751 0.007 0 0
Defective pyroptosis R-HSA-9710421 0.985186 0.006 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.985186 0.006 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.985186 0.006 0 0
DNA methylation R-HSA-5334118 0.985635 0.006 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 0.985635 0.006 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.985635 0.006 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 0.986659 0.006 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 0.987277 0.006 0 0
Neurotransmitter clearance R-HSA-112311 0.987277 0.006 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.987297 0.006 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.987538 0.005 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.987988 0.005 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.988731 0.005 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 0.988731 0.005 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.989152 0.005 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.989188 0.005 0 0
Interferon gamma signaling R-HSA-877300 0.990009 0.004 1 1
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.990019 0.004 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.990019 0.004 0 0
DAG1 glycosylations R-HSA-8931838 0.990019 0.004 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.990649 0.004 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.990692 0.004 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.991010 0.004 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.991160 0.004 0 0
Defective B3GALTL causes PpS R-HSA-5083635 0.991160 0.004 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.991160 0.004 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 0.991160 0.004 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.991218 0.004 0 0
Translation of Structural Proteins R-HSA-9694635 0.991786 0.004 0 0
Chemokine receptors bind chemokines R-HSA-380108 0.992128 0.003 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.992170 0.003 0 0
Base Excision Repair R-HSA-73884 0.992469 0.003 0 0
Cholesterol biosynthesis R-HSA-191273 0.992494 0.003 0 0
Cellular response to hypoxia R-HSA-1234174 0.993004 0.003 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.993065 0.003 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.993065 0.003 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.993065 0.003 0 0
RA biosynthesis pathway R-HSA-5365859 0.993065 0.003 0 0
Calnexin/calreticulin cycle R-HSA-901042 0.993065 0.003 0 0
Signal amplification R-HSA-392518 0.993065 0.003 0 0
MHC class II antigen presentation R-HSA-2132295 0.993179 0.003 0 0
HCMV Infection R-HSA-9609646 0.993505 0.003 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.993858 0.003 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.993858 0.003 0 0
Regulation of Apoptosis R-HSA-169911 0.993858 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 0.993858 0.003 0 0
Amyloid fiber formation R-HSA-977225 0.994283 0.002 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.994561 0.002 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.994561 0.002 0 0
Glycosphingolipid transport R-HSA-9845576 0.994561 0.002 0 0
HS-GAG biosynthesis R-HSA-2022928 0.994561 0.002 0 0
Triglyceride catabolism R-HSA-163560 0.994561 0.002 0 0
Phospholipid metabolism R-HSA-1483257 0.994575 0.002 0 0
HCMV Late Events R-HSA-9610379 0.994575 0.002 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.994758 0.002 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.994758 0.002 0 0
SARS-CoV Infections R-HSA-9679506 0.995077 0.002 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 0.995182 0.002 0 0
Voltage gated Potassium channels R-HSA-1296072 0.995182 0.002 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.995182 0.002 0 0
Degradation of AXIN R-HSA-4641257 0.995182 0.002 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.995182 0.002 0 0
SLC-mediated transport of organic cations R-HSA-549127 0.995182 0.002 0 0
Lysine catabolism R-HSA-71064 0.995182 0.002 0 0
Collagen chain trimerization R-HSA-8948216 0.995182 0.002 0 0
Metabolism of folate and pterines R-HSA-196757 0.995182 0.002 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.995657 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.995711 0.002 0 0
tRNA processing in the mitochondrion R-HSA-6785470 0.995733 0.002 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.995733 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.996115 0.002 0 0
Metabolism of cofactors R-HSA-8978934 0.996115 0.002 0 0
RAS processing R-HSA-9648002 0.996221 0.002 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.996221 0.002 0 0
Pentose phosphate pathway R-HSA-71336 0.996221 0.002 0 0
Telomere Maintenance R-HSA-157579 0.996542 0.002 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.996653 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 0.996653 0.001 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.996653 0.001 0 0
Tryptophan catabolism R-HSA-71240 0.996653 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 0.996653 0.001 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.996777 0.001 0 0
DNA Replication R-HSA-69306 0.996826 0.001 0 0
Protein localization R-HSA-9609507 0.996826 0.001 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.996999 0.001 0 0
Pyruvate metabolism R-HSA-70268 0.997003 0.001 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.997036 0.001 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.997036 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.997036 0.001 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.997036 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 0.997036 0.001 0 0
Aflatoxin activation and detoxification R-HSA-5423646 0.997036 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.997115 0.001 0 0
Neddylation R-HSA-8951664 0.997181 0.001 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.997206 0.001 0 0
Peroxisomal protein import R-HSA-9033241 0.997306 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.997375 0.001 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 0.997375 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 0.997389 0.001 0 0
Adaptive Immune System R-HSA-1280218 0.997429 0.001 0 0
ER-Phagosome pathway R-HSA-1236974 0.997514 0.001 0 0
Metabolism of polyamines R-HSA-351202 0.997583 0.001 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.997675 0.001 0 0
Depyrimidination R-HSA-73928 0.997675 0.001 0 0
Collagen degradation R-HSA-1442490 0.997832 0.001 0 0
ABC transporter disorders R-HSA-5619084 0.998067 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 0.998177 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.998245 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.998295 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.998385 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.998570 0.001 0 0
Collagen formation R-HSA-1474290 0.998590 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.998619 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 0.998734 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.998818 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.998834 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 0.998873 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 0.998879 0.000 0 0
Gluconeogenesis R-HSA-70263 0.998879 0.000 0 0
SLC transporter disorders R-HSA-5619102 0.998883 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.999007 0.000 0 0
Azathioprine ADME R-HSA-9748787 0.999121 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.999180 0.000 0 0
Hemostasis R-HSA-109582 0.999205 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 0.999221 0.000 0 0
Complex IV assembly R-HSA-9864848 0.999221 0.000 0 0
The phototransduction cascade R-HSA-2514856 0.999221 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 0.999274 0.000 0 0
Metabolism of porphyrins R-HSA-189445 0.999274 0.000 0 0
Extracellular matrix organization R-HSA-1474244 0.999286 0.000 0 0
Gastrulation R-HSA-9758941 0.999361 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 0.999389 0.000 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.999459 0.000 0 0
Dectin-2 family R-HSA-5621480 0.999624 0.000 0 0
Synthesis of PA R-HSA-1483166 0.999624 0.000 0 0
G alpha (q) signalling events R-HSA-416476 0.999652 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 0.999706 0.000 0 0
Triglyceride metabolism R-HSA-8979227 0.999706 0.000 0 0
Viral Infection Pathways R-HSA-9824446 0.999714 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 0.999739 0.000 0 0
Glutathione conjugation R-HSA-156590 0.999739 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.999739 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.999760 0.000 0 0
Endogenous sterols R-HSA-211976 0.999769 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 0.999778 0.000 0 0
Translation R-HSA-72766 0.999819 0.000 0 0
Complex I biogenesis R-HSA-6799198 0.999819 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.999833 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.999837 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 0.999840 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999865 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.999878 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 0.999878 0.000 0 0
Nicotinate metabolism R-HSA-196807 0.999889 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999900 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.999901 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.999909 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999925 0.000 0 0
ECM proteoglycans R-HSA-3000178 0.999932 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 0.999932 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.999944 0.000 0 0
GPCR downstream signalling R-HSA-388396 0.999944 0.000 1 0
Diseases of carbohydrate metabolism R-HSA-5663084 0.999946 0.000 0 0
Aspirin ADME R-HSA-9749641 0.999946 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.999954 0.000 0 0
Iron uptake and transport R-HSA-917937 0.999958 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.999966 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 0.999974 0.000 0 0
G alpha (s) signalling events R-HSA-418555 0.999974 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 0.999975 0.000 0 0
G alpha (i) signalling events R-HSA-418594 0.999977 0.000 1 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.999979 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.999979 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 0.999980 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.999982 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.999986 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 0.999986 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.999990 0.000 0 0
Immune System R-HSA-168256 0.999997 0.000 1 0
Post-translational protein modification R-HSA-597592 0.999998 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 0.999998 0.000 0 0
Potassium Channels R-HSA-1296071 0.999998 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.999998 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 0.999999 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.999999 0.000 0 0
Signaling by GPCR R-HSA-372790 0.999999 0.000 1 0
Mitochondrial translation R-HSA-5368287 0.999999 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.999999 0.000 0 0
Innate Immune System R-HSA-168249 0.999999 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 0.999999 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999999 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000 0.000 0 0
Antimicrobial peptides R-HSA-6803157 1.000000 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000 0.000 0 0
Keratinization R-HSA-6805567 1.000000 0.000 0 0
Infectious disease R-HSA-5663205 1.000000 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 0.000 1 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 0 0
Drug ADME R-HSA-9748784 1.000000 0.000 0 0
Disease R-HSA-1643685 1.000000 0.000 1 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 -0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 4.440892e-16 15.353 0 0
Cell Cycle, Mitotic R-HSA-69278 1.154632e-14 13.938 0 0
M Phase R-HSA-68886 6.050715e-14 13.218 0 0
Metabolism of RNA R-HSA-8953854 1.236788e-13 12.908 0 0
Cellular responses to stimuli R-HSA-8953897 9.710011e-13 12.013 1 0
Mitotic Prophase R-HSA-68875 1.102640e-11 10.958 0 0
Cellular responses to stress R-HSA-2262752 4.203671e-11 10.376 1 0
Cell-Cell communication R-HSA-1500931 4.660305e-11 10.332 0 0
Nucleosome assembly R-HSA-774815 6.155945e-10 9.211 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.155945e-10 9.211 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.180584e-10 9.286 0 0
Cell Cycle Checkpoints R-HSA-69620 6.025452e-10 9.220 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.489648e-09 8.827 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.769301e-09 8.752 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.615220e-09 8.582 0 0
Axon guidance R-HSA-422475 2.947905e-09 8.530 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.471110e-09 8.460 0 0
Cell junction organization R-HSA-446728 3.731095e-09 8.428 0 0
HDACs deacetylate histones R-HSA-3214815 4.287404e-09 8.368 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.836320e-09 8.315 0 0
Nervous system development R-HSA-9675108 5.860317e-09 8.232 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.636061e-09 8.178 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.591605e-09 8.181 0 0
G2/M Checkpoints R-HSA-69481 6.430304e-09 8.192 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.299778e-09 8.137 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.686984e-09 8.014 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.655982e-08 7.781 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.655982e-08 7.781 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.792206e-08 7.747 0 0
Apoptotic execution phase R-HSA-75153 1.864434e-08 7.729 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.071777e-08 7.684 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.857804e-08 7.544 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.857804e-08 7.544 0 0
Apoptosis R-HSA-109581 2.946844e-08 7.531 0 0
Chromatin organization R-HSA-4839726 3.163785e-08 7.500 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.558097e-08 7.449 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.498045e-08 7.456 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.836811e-08 7.416 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.716197e-08 7.326 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.599996e-08 7.337 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.501697e-08 7.347 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.768720e-08 7.239 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.558711e-08 7.122 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.184147e-07 6.927 0 0
Signaling by ROBO receptors R-HSA-376176 1.403324e-07 6.853 0 0
Meiotic synapsis R-HSA-1221632 1.581735e-07 6.801 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.581735e-07 6.801 0 0
Influenza Infection R-HSA-168255 1.728938e-07 6.762 0 0
Adherens junctions interactions R-HSA-418990 2.072053e-07 6.684 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.353195e-07 6.628 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.776264e-07 6.557 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.885828e-07 6.540 0 0
Chromatin modifying enzymes R-HSA-3247509 2.919469e-07 6.535 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.067742e-07 6.513 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.289682e-07 6.483 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.281625e-07 6.484 0 0
Mitotic Anaphase R-HSA-68882 3.671176e-07 6.435 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.864336e-07 6.413 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.864336e-07 6.413 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.153501e-07 6.382 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.334810e-07 6.363 0 0
RNA Polymerase I Transcription R-HSA-73864 4.919352e-07 6.308 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.974090e-07 6.303 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.604919e-07 6.180 0 0
HATs acetylate histones R-HSA-3214847 7.056800e-07 6.151 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.863524e-07 6.052 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.352489e-07 6.029 0 0
mRNA Splicing R-HSA-72172 9.612366e-07 6.017 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.025575e-06 5.989 0 0
DNA methylation R-HSA-5334118 1.057710e-06 5.976 0 0
Mitotic Prometaphase R-HSA-68877 1.113322e-06 5.953 0 0
Programmed Cell Death R-HSA-5357801 1.085876e-06 5.964 0 0
Peptide chain elongation R-HSA-156902 1.520862e-06 5.818 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.667543e-06 5.778 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.705366e-06 5.768 0 0
Meiosis R-HSA-1500620 2.088545e-06 5.680 0 0
Cell-cell junction organization R-HSA-421270 1.997985e-06 5.699 0 0
Defective pyroptosis R-HSA-9710421 2.163787e-06 5.665 0 0
Packaging Of Telomere Ends R-HSA-171306 2.429398e-06 5.615 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.423524e-06 5.616 0 0
rRNA processing R-HSA-72312 2.378632e-06 5.624 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.681021e-06 5.572 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.688115e-06 5.571 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.891442e-06 5.539 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.979362e-06 5.526 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.570292e-06 5.447 0 0
HCMV Early Events R-HSA-9609690 3.590210e-06 5.445 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.625264e-06 5.441 0 0
ESR-mediated signaling R-HSA-8939211 4.081163e-06 5.389 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.093118e-06 5.388 1 0
Diseases of programmed cell death R-HSA-9645723 4.449328e-06 5.352 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.551658e-06 5.342 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.609213e-06 5.336 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.734567e-06 5.325 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.102266e-06 5.292 0 0
DNA Double Strand Break Response R-HSA-5693606 4.857355e-06 5.314 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.310873e-06 5.275 0 0
Viral Infection Pathways R-HSA-9824446 5.988194e-06 5.223 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.034618e-06 5.219 0 0
Chromosome Maintenance R-HSA-73886 6.197166e-06 5.208 0 0
L1CAM interactions R-HSA-373760 7.415054e-06 5.130 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.034803e-06 5.153 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.596126e-06 5.119 0 0
Eukaryotic Translation Termination R-HSA-72764 7.739273e-06 5.111 0 0
Separation of Sister Chromatids R-HSA-2467813 8.249727e-06 5.084 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.039155e-06 5.044 0 0
Gene Silencing by RNA R-HSA-211000 9.039155e-06 5.044 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.006057e-05 4.997 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.055159e-05 4.977 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.256884e-05 4.901 0 0
Cellular Senescence R-HSA-2559583 1.275881e-05 4.894 0 0
Ribosome-associated quality control R-HSA-9948299 1.708720e-05 4.767 0 0
Meiotic recombination R-HSA-912446 1.625886e-05 4.789 0 0
Signal Transduction R-HSA-162582 1.757406e-05 4.755 1 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.767098e-05 4.753 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.777698e-05 4.750 1 1
Cleavage of the damaged purine R-HSA-110331 1.777955e-05 4.750 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.795867e-05 4.746 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.823569e-05 4.739 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.838359e-05 4.736 0 0
Depurination R-HSA-73927 2.320908e-05 4.634 0 0
Viral mRNA Translation R-HSA-192823 2.773455e-05 4.557 0 0
Interleukin-12 signaling R-HSA-9020591 2.810711e-05 4.551 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.877568e-05 4.541 0 0
Interleukin-12 family signaling R-HSA-447115 2.901456e-05 4.537 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.968741e-05 4.527 1 1
HCMV Infection R-HSA-9609646 2.981374e-05 4.526 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.075013e-05 4.512 1 1
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.103447e-05 4.508 0 0
Translation initiation complex formation R-HSA-72649 3.148837e-05 4.502 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.375081e-05 4.472 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.660787e-05 4.332 0 0
Muscle contraction R-HSA-397014 4.688781e-05 4.329 1 0
Base Excision Repair R-HSA-73884 4.713802e-05 4.327 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.772439e-05 4.321 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.931415e-05 4.307 0 0
Selenocysteine synthesis R-HSA-2408557 5.193593e-05 4.285 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.378912e-05 4.269 0 0
DNA Replication R-HSA-69306 5.378912e-05 4.269 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.391759e-05 4.268 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.551551e-05 4.256 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.250376e-05 4.204 1 1
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.101176e-05 4.149 0 0
Post NMDA receptor activation events R-HSA-438064 7.681740e-05 4.115 1 0
TCF dependent signaling in response to WNT R-HSA-201681 7.856101e-05 4.105 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.869842e-05 4.104 0 0
Depyrimidination R-HSA-73928 7.869842e-05 4.104 0 0
Signaling by WNT R-HSA-195721 7.941464e-05 4.100 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.544833e-05 4.068 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 9.019475e-05 4.045 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.682718e-05 4.014 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.065229e-04 3.973 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.203407e-04 3.920 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.334782e-04 3.875 1 1
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.493817e-04 3.826 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.494166e-04 3.826 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.709860e-04 3.767 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.794167e-04 3.746 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.794167e-04 3.746 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.860625e-04 3.730 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.860625e-04 3.730 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.860625e-04 3.730 1 1
Signaling by RAS mutants R-HSA-6802949 1.860625e-04 3.730 1 0
Cellular response to heat stress R-HSA-3371556 1.964543e-04 3.707 1 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.259059e-04 3.646 0 0
Recycling pathway of L1 R-HSA-437239 2.274795e-04 3.643 0 0
Ub-specific processing proteases R-HSA-5689880 2.384430e-04 3.623 0 0
Smooth Muscle Contraction R-HSA-445355 2.409126e-04 3.618 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.418350e-04 3.616 1 1
Interferon Signaling R-HSA-913531 2.713978e-04 3.566 1 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.894645e-04 3.538 0 0
Homology Directed Repair R-HSA-5693538 3.049869e-04 3.516 0 0
Striated Muscle Contraction R-HSA-390522 3.067215e-04 3.513 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.226935e-04 3.491 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.242208e-04 3.489 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.428732e-04 3.465 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.432909e-04 3.464 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.515651e-04 3.454 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.515651e-04 3.454 0 0
Co-inhibition by PD-1 R-HSA-389948 3.916914e-04 3.407 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.219669e-04 3.375 0 0
Long-term potentiation R-HSA-9620244 4.248697e-04 3.372 1 1
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.334273e-04 3.363 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.395766e-04 3.357 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.595189e-04 3.338 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.233845e-04 3.281 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.520595e-04 3.258 1 1
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.617029e-04 3.250 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.105502e-04 3.214 0 0
Reproduction R-HSA-1474165 6.719579e-04 3.173 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.017849e-04 3.154 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 7.017849e-04 3.154 0 0
HCMV Late Events R-HSA-9610379 7.179695e-04 3.144 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.265782e-04 3.139 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.265782e-04 3.139 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.349874e-04 3.134 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.435080e-04 3.129 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.612538e-04 3.118 1 0
AURKA Activation by TPX2 R-HSA-8854518 7.749689e-04 3.111 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.752298e-04 3.111 1 0
G2/M Transition R-HSA-69275 7.798292e-04 3.108 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.210959e-04 3.086 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.432581e-04 3.025 0 0
Amplification of signal from the kinetochores R-HSA-141424 8.679581e-04 3.062 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 8.679581e-04 3.062 0 0
Telomere Maintenance R-HSA-157579 9.512800e-04 3.022 0 0
Rap1 signalling R-HSA-392517 9.420318e-04 3.026 0 0
Signaling by NOTCH R-HSA-157118 9.562632e-04 3.019 0 0
Deubiquitination R-HSA-5688426 9.372685e-04 3.028 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.232676e-04 3.035 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.619446e-04 3.065 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.788838e-04 3.009 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 9.986977e-04 3.001 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.016244e-03 2.993 0 0
Nephrin family interactions R-HSA-373753 1.245041e-03 2.905 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.248470e-03 2.904 0 0
Nuclear import of Rev protein R-HSA-180746 1.248470e-03 2.904 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.260153e-03 2.900 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.260153e-03 2.900 0 0
Regulation of CDH1 Function R-HSA-9764561 1.308534e-03 2.883 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.318429e-03 2.880 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.318429e-03 2.880 0 0
Glycolysis R-HSA-70171 1.348786e-03 2.870 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.402841e-03 2.853 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.522971e-03 2.817 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.537235e-03 2.813 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.537235e-03 2.813 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.733384e-03 2.761 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.733384e-03 2.761 0 0
snRNP Assembly R-HSA-191859 1.767896e-03 2.753 0 0
Metabolism of non-coding RNA R-HSA-194441 1.767896e-03 2.753 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.808481e-03 2.743 0 0
DNA Repair R-HSA-73894 1.839081e-03 2.735 0 0
CaM pathway R-HSA-111997 1.845377e-03 2.734 1 0
Calmodulin induced events R-HSA-111933 1.845377e-03 2.734 1 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.142383e-03 2.669 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.221747e-03 2.653 0 0
PKR-mediated signaling R-HSA-9833482 2.163272e-03 2.665 0 0
Ca-dependent events R-HSA-111996 2.244232e-03 2.649 1 0
G-protein mediated events R-HSA-112040 2.212067e-03 2.655 1 0
S Phase R-HSA-69242 2.269818e-03 2.644 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.086775e-03 2.681 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.978798e-03 2.704 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.275160e-03 2.643 0 0
Protein folding R-HSA-391251 2.287916e-03 2.641 0 0
PLC beta mediated events R-HSA-112043 2.355232e-03 2.628 1 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.383179e-03 2.623 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.383179e-03 2.623 1 1
Apoptosis induced DNA fragmentation R-HSA-140342 2.383179e-03 2.623 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.383179e-03 2.623 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.403868e-03 2.619 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.403868e-03 2.619 0 0
Amyloid fiber formation R-HSA-977225 2.444054e-03 2.612 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.453177e-03 2.610 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.484712e-03 2.605 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.514271e-03 2.600 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.585207e-03 2.588 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.585207e-03 2.588 0 0
HIV Life Cycle R-HSA-162587 2.600844e-03 2.585 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.658568e-03 2.575 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.704888e-03 2.568 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.802048e-03 2.553 0 0
Cellular response to starvation R-HSA-9711097 2.823737e-03 2.549 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.868633e-03 2.542 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.096509e-03 2.509 0 0
RMTs methylate histone arginines R-HSA-3214858 3.117307e-03 2.506 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.122910e-03 2.505 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.162738e-03 2.500 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.475965e-03 2.459 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.494512e-03 2.457 0 0
DAG and IP3 signaling R-HSA-1489509 3.647640e-03 2.438 1 0
Aggrephagy R-HSA-9646399 3.741556e-03 2.427 0 0
Opioid Signalling R-HSA-111885 4.307024e-03 2.366 1 0
Cytokine Signaling in Immune system R-HSA-1280215 4.501583e-03 2.347 1 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.588026e-03 2.338 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.713064e-03 2.327 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.805152e-03 2.318 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.751764e-03 2.323 0 0
HIV Infection R-HSA-162906 5.567741e-03 2.254 0 0
Kinesins R-HSA-983189 4.947221e-03 2.306 0 0
SARS-CoV Infections R-HSA-9679506 5.211775e-03 2.283 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.607766e-03 2.251 0 0
Signaling by VEGF R-HSA-194138 5.764925e-03 2.239 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.844388e-03 2.233 1 0
Centrosome maturation R-HSA-380287 5.938621e-03 2.226 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.036292e-03 2.219 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.036292e-03 2.219 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.233826e-03 2.205 0 0
DNA strand elongation R-HSA-69190 6.324531e-03 2.199 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.140245e-03 2.146 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.337579e-03 2.134 0 0
G-protein beta:gamma signalling R-HSA-397795 7.506982e-03 2.125 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.506982e-03 2.125 1 0
Translation R-HSA-72766 7.797835e-03 2.108 0 0
Selenoamino acid metabolism R-HSA-2408522 7.956153e-03 2.099 0 0
Signaling by Hippo R-HSA-2028269 7.994858e-03 2.097 0 0
Unwinding of DNA R-HSA-176974 8.186833e-03 2.087 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.353683e-03 2.078 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.514317e-03 2.070 0 0
mTORC1-mediated signalling R-HSA-166208 8.760115e-03 2.057 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.981967e-03 2.047 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.981967e-03 2.047 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.981967e-03 2.047 1 1
Activation of HOX genes during differentiation R-HSA-5619507 9.297324e-03 2.032 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.297324e-03 2.032 0 0
Glucose metabolism R-HSA-70326 9.437629e-03 2.025 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 9.517134e-03 2.021 0 0
mRNA 3'-end processing R-HSA-72187 9.731933e-03 2.012 0 0
Gene expression (Transcription) R-HSA-74160 9.835233e-03 2.007 1 0
Cilium Assembly R-HSA-5617833 1.010528e-02 1.995 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.063986e-02 1.973 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.125947e-02 1.948 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.137625e-02 1.944 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.137625e-02 1.944 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.147859e-02 1.940 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.169915e-02 1.932 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.182653e-02 1.927 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.204676e-02 1.919 0 0
Signaling by ALK in cancer R-HSA-9700206 1.204676e-02 1.919 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.239842e-02 1.907 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.245413e-02 1.905 0 0
Activation of the pre-replicative complex R-HSA-68962 1.261862e-02 1.899 0 0
Activation of BH3-only proteins R-HSA-114452 1.261862e-02 1.899 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.268415e-02 1.897 0 0
MAP2K and MAPK activation R-HSA-5674135 1.306196e-02 1.884 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.361731e-02 1.866 0 0
UCH proteinases R-HSA-5689603 1.392419e-02 1.856 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.404353e-02 1.853 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.404353e-02 1.853 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.515934e-02 1.819 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.493048e-02 1.826 0 0
Trafficking of AMPA receptors R-HSA-399719 1.480148e-02 1.830 1 1
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.480148e-02 1.830 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.728290e-02 1.762 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.754732e-02 1.756 0 0
Regulation of TP53 Activity R-HSA-5633007 1.745039e-02 1.758 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.572909e-02 1.803 0 0
IRE1alpha activates chaperones R-HSA-381070 1.741865e-02 1.759 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.799972e-02 1.745 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.799972e-02 1.745 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.799972e-02 1.745 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.799972e-02 1.745 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.799972e-02 1.745 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.799972e-02 1.745 0 0
G1/S Transition R-HSA-69206 1.890259e-02 1.723 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.944886e-02 1.711 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.962173e-02 1.707 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.971217e-02 1.705 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.998247e-02 1.699 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.998247e-02 1.699 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.998247e-02 1.699 1 0
Intracellular signaling by second messengers R-HSA-9006925 2.018061e-02 1.695 1 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.099376e-02 1.678 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.168352e-02 1.664 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.174608e-02 1.663 0 0
Platelet degranulation R-HSA-114608 2.177612e-02 1.662 0 0
Orc1 removal from chromatin R-HSA-68949 2.193408e-02 1.659 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.193408e-02 1.659 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.193792e-02 1.659 0 0
Membrane Trafficking R-HSA-199991 2.248160e-02 1.648 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.343764e-02 1.630 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.397048e-02 1.620 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.397048e-02 1.620 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.419592e-02 1.616 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.445811e-02 1.612 0 0
Infectious disease R-HSA-5663205 2.501141e-02 1.602 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.527729e-02 1.597 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.528223e-02 1.597 0 0
RAF activation R-HSA-5673000 2.635980e-02 1.579 1 1
RNA Polymerase II Transcription Termination R-HSA-73856 2.675824e-02 1.573 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.690517e-02 1.570 1 1
Type I hemidesmosome assembly R-HSA-446107 2.690517e-02 1.570 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.690517e-02 1.570 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.690517e-02 1.570 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.717526e-02 1.566 0 0
TCR signaling R-HSA-202403 2.761294e-02 1.559 0 0
Host Interactions of HIV factors R-HSA-162909 2.833108e-02 1.548 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.849025e-02 1.545 0 0
Late endosomal microautophagy R-HSA-9615710 2.862417e-02 1.543 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.892347e-02 1.539 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.994849e-02 1.524 1 0
G alpha (z) signalling events R-HSA-418597 3.019814e-02 1.520 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.115349e-02 1.506 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.115349e-02 1.506 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.137829e-02 1.503 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.172582e-02 1.499 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.172582e-02 1.499 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.235574e-02 1.490 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.235574e-02 1.490 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.235574e-02 1.490 0 0
Semaphorin interactions R-HSA-373755 3.247068e-02 1.489 0 0
G alpha (12/13) signalling events R-HSA-416482 3.287923e-02 1.483 0 0
Ion homeostasis R-HSA-5578775 3.339454e-02 1.476 1 1
Intrinsic Pathway for Apoptosis R-HSA-109606 3.339454e-02 1.476 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.405433e-02 1.468 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.405433e-02 1.468 0 0
EPH-Ephrin signaling R-HSA-2682334 3.499255e-02 1.456 0 0
MAPK family signaling cascades R-HSA-5683057 3.515964e-02 1.454 1 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.526213e-02 1.453 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.526213e-02 1.453 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.526213e-02 1.453 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.526213e-02 1.453 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.537222e-02 1.451 0 0
NrCAM interactions R-HSA-447038 3.537222e-02 1.451 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.563862e-02 1.448 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.563862e-02 1.448 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.568892e-02 1.447 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.790808e-02 1.421 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.908727e-02 1.309 0 0
2-LTR circle formation R-HSA-164843 4.495923e-02 1.347 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.826242e-02 1.417 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.628524e-02 1.335 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.736796e-02 1.325 0 0
HSF1-dependent transactivation R-HSA-3371571 4.177832e-02 1.379 1 1
Ca2+ pathway R-HSA-4086398 4.072053e-02 1.390 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.736796e-02 1.325 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.740821e-02 1.324 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.829063e-02 1.316 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.790808e-02 1.421 0 0
Gap junction trafficking R-HSA-190828 4.273119e-02 1.369 0 0
Signal transduction by L1 R-HSA-445144 4.439174e-02 1.353 0 0
Protein ubiquitination R-HSA-8852135 4.795137e-02 1.319 0 0
Selective autophagy R-HSA-9663891 4.299563e-02 1.367 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.027729e-02 1.299 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.842502e-02 1.315 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.273119e-02 1.369 0 0
Signaling by NOTCH4 R-HSA-9013694 4.423219e-02 1.354 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.772008e-02 1.423 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.122583e-02 1.385 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.908727e-02 1.309 0 0
Death Receptor Signaling R-HSA-73887 5.094842e-02 1.293 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.175572e-02 1.286 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.175572e-02 1.286 0 0
PTEN Regulation R-HSA-6807070 5.225862e-02 1.282 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.281201e-02 1.277 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.303200e-02 1.275 0 0
Generation of second messenger molecules R-HSA-202433 5.379612e-02 1.269 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.448909e-02 1.264 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.448909e-02 1.264 0 0
PECAM1 interactions R-HSA-210990 5.599704e-02 1.252 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.685199e-02 1.245 0 0
tRNA processing in the nucleus R-HSA-6784531 5.773524e-02 1.239 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.969489e-02 1.224 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.982154e-02 1.223 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.039934e-02 1.219 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.065578e-02 1.217 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.101739e-02 1.215 0 0
Gap junction assembly R-HSA-190861 6.101739e-02 1.215 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.311740e-02 1.200 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.311740e-02 1.200 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.311740e-02 1.200 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.311740e-02 1.200 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.311740e-02 1.200 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.311740e-02 1.200 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.311740e-02 1.200 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.311740e-02 1.200 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.311740e-02 1.200 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.311740e-02 1.200 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.311740e-02 1.200 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.311740e-02 1.200 0 0
GPER1 signaling R-HSA-9634597 6.345826e-02 1.198 0 0
Co-stimulation by CD28 R-HSA-389356 6.345826e-02 1.198 0 0
Sensory processing of sound R-HSA-9659379 6.499193e-02 1.187 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.500478e-02 1.187 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.511150e-02 1.186 0 0
Synthesis of DNA R-HSA-69239 6.517020e-02 1.186 0 0
Hedgehog 'off' state R-HSA-5610787 6.549713e-02 1.184 0 0
NRAGE signals death through JNK R-HSA-193648 6.612745e-02 1.180 0 0
Adaptive Immune System R-HSA-1280218 6.712531e-02 1.173 0 0
Integration of provirus R-HSA-162592 6.835547e-02 1.165 0 0
Gap junction trafficking and regulation R-HSA-157858 6.949998e-02 1.158 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.953324e-02 1.158 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.269342e-02 1.139 0 0
MTOR signalling R-HSA-165159 7.269342e-02 1.139 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.442074e-02 1.128 0 0
RET signaling R-HSA-8853659 7.548672e-02 1.122 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.591028e-02 1.120 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.591028e-02 1.120 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.750292e-02 1.111 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.807011e-02 1.108 0 0
Syndecan interactions R-HSA-3000170 7.807011e-02 1.108 0 0
Developmental Biology R-HSA-1266738 7.910347e-02 1.102 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.199618e-02 1.086 0 0
Pervasive developmental disorders R-HSA-9005895 8.199618e-02 1.086 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.199618e-02 1.086 0 0
Disorders of Nervous System Development R-HSA-9697154 8.199618e-02 1.086 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.199618e-02 1.086 0 0
TRIF-mediated programmed cell death R-HSA-2562578 8.297127e-02 1.081 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.297127e-02 1.081 0 0
CHL1 interactions R-HSA-447041 8.297127e-02 1.081 0 0
Autophagy R-HSA-9612973 8.561418e-02 1.067 0 0
Inositol phosphate metabolism R-HSA-1483249 8.724133e-02 1.059 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.761460e-02 1.057 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.761460e-02 1.057 0 0
Mismatch Repair R-HSA-5358508 8.761460e-02 1.057 0 0
PKA activation R-HSA-163615 8.761460e-02 1.057 0 0
Ephrin signaling R-HSA-3928664 8.761460e-02 1.057 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 8.824548e-02 1.054 0 0
Neurodegenerative Diseases R-HSA-8863678 8.824548e-02 1.054 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.971581e-02 1.047 0 0
Neurexins and neuroligins R-HSA-6794361 8.974642e-02 1.047 0 0
Signaling by ERBB2 R-HSA-1227986 9.113462e-02 1.040 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.175323e-02 1.037 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.242048e-02 1.034 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 9.242048e-02 1.034 0 0
MET activates PTPN11 R-HSA-8865999 9.242048e-02 1.034 0 0
Nucleotide Excision Repair R-HSA-5696398 9.371777e-02 1.028 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.523138e-02 1.021 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 9.649617e-02 1.015 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.649617e-02 1.015 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 9.686509e-02 1.014 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.739223e-02 1.011 0 0
HDMs demethylate histones R-HSA-3214842 9.910834e-02 1.004 0 0
Interleukin-7 signaling R-HSA-1266695 9.910834e-02 1.004 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.002005e-01 0.999 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.006920e-01 0.997 0 0
Formation of annular gap junctions R-HSA-196025 1.028039e-01 0.988 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.028039e-01 0.988 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.028039e-01 0.988 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.028039e-01 0.988 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.028039e-01 0.988 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.053482e-01 0.977 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.060300e-01 0.975 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.247935e-01 0.904 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.247935e-01 0.904 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.247935e-01 0.904 0 0
IRS activation R-HSA-74713 1.593720e-01 0.798 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.593720e-01 0.798 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.593720e-01 0.798 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.243013e-01 0.906 0 0
Gap junction degradation R-HSA-190873 1.243013e-01 0.906 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.472521e-01 0.832 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.300075e-01 0.886 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.300075e-01 0.886 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.136365e-01 0.944 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.136365e-01 0.944 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.481163e-01 0.829 0 0
Lagging Strand Synthesis R-HSA-69186 1.278847e-01 0.893 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.586381e-01 0.800 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.166389e-01 0.933 0 0
Dual Incision in GG-NER R-HSA-5696400 1.277774e-01 0.894 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.496492e-01 0.825 0 0
HSF1 activation R-HSA-3371511 1.515753e-01 0.819 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 1.106429e-01 0.956 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.394292e-01 0.856 0 0
Muscarinic acetylcholine receptors R-HSA-390648 1.593720e-01 0.798 0 0
Regulation of CDH11 function R-HSA-9762292 1.472521e-01 0.832 0 0
PI3K/AKT activation R-HSA-198203 1.472521e-01 0.832 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.100914e-01 0.958 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.358984e-01 0.867 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 1.278847e-01 0.893 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.408477e-01 0.851 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.278847e-01 0.893 0 0
Myogenesis R-HSA-525793 1.106429e-01 0.956 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.106429e-01 0.956 0 0
NADE modulates death signalling R-HSA-205025 1.247935e-01 0.904 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.243013e-01 0.906 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.300075e-01 0.886 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.490562e-01 0.827 0 0
Signaling by SCF-KIT R-HSA-1433557 1.519610e-01 0.818 0 0
Regulation of insulin secretion R-HSA-422356 1.496492e-01 0.825 0 0
Degradation of CDH1 R-HSA-9766229 1.308938e-01 0.883 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.106429e-01 0.956 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.593720e-01 0.798 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 1.243013e-01 0.906 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.349358e-01 0.870 1 1
RNA Polymerase II Transcription R-HSA-73857 1.082626e-01 0.966 1 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.270053e-01 0.896 1 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.200696e-01 0.921 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.228291e-01 0.911 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.312272e-01 0.882 0 0
Basigin interactions R-HSA-210991 1.278847e-01 0.893 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.510753e-01 0.821 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.125690e-01 0.949 0 0
Maturation of spike protein R-HSA-9683686 1.472521e-01 0.832 0 0
Zinc transporters R-HSA-435354 1.128949e-01 0.947 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.472521e-01 0.832 0 0
CASP4 inflammasome assembly R-HSA-9948001 1.472521e-01 0.832 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 1.243013e-01 0.906 0 0
Metal ion SLC transporters R-HSA-425410 1.213909e-01 0.916 0 0
Signaling by Interleukins R-HSA-449147 1.066545e-01 0.972 0 0
Signaling by Leptin R-HSA-2586552 1.472521e-01 0.832 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.243013e-01 0.906 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.593720e-01 0.798 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.630387e-01 0.788 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.630387e-01 0.788 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.630387e-01 0.788 0 0
Proteasome assembly R-HSA-9907900 1.634812e-01 0.787 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.634812e-01 0.787 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.655313e-01 0.781 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.671286e-01 0.777 0 0
Disorders of Developmental Biology R-HSA-9675151 1.671286e-01 0.777 0 0
Signaling by Hedgehog R-HSA-5358351 1.681909e-01 0.774 0 0
Aquaporin-mediated transport R-HSA-445717 1.692258e-01 0.772 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.714420e-01 0.766 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.714420e-01 0.766 0 0
Suppression of apoptosis R-HSA-9635465 1.714420e-01 0.766 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.750421e-01 0.757 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.753917e-01 0.756 0 0
Developmental Cell Lineages R-HSA-9734767 1.821579e-01 0.740 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.836860e-01 0.736 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.836860e-01 0.736 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.836860e-01 0.736 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.836860e-01 0.736 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.836860e-01 0.736 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.836860e-01 0.736 0 0
Inhibition of PKR R-HSA-169131 1.836860e-01 0.736 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.869471e-01 0.728 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 1.869471e-01 0.728 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.920577e-01 0.717 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.954295e-01 0.709 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.954295e-01 0.709 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.954295e-01 0.709 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.954295e-01 0.709 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.954295e-01 0.709 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.954295e-01 0.709 0 0
Signaling by NOTCH3 R-HSA-9012852 1.954766e-01 0.709 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.966586e-01 0.706 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.966586e-01 0.706 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 1.966586e-01 0.706 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.966586e-01 0.706 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.966586e-01 0.706 0 0
Interferon gamma signaling R-HSA-877300 1.970398e-01 0.705 1 1
Generic Transcription Pathway R-HSA-212436 2.040246e-01 0.690 1 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.046529e-01 0.689 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.059276e-01 0.686 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.073813e-01 0.683 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.624664e-01 0.581 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.624664e-01 0.581 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.624664e-01 0.581 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.624664e-01 0.581 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.624664e-01 0.581 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.624664e-01 0.581 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.624664e-01 0.581 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.624664e-01 0.581 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.624664e-01 0.581 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.624664e-01 0.581 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.336482e-01 0.477 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.336482e-01 0.477 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.336482e-01 0.477 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.336482e-01 0.477 0 0
Signaling by LTK in cancer R-HSA-9842640 2.323590e-01 0.634 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.323590e-01 0.634 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.323590e-01 0.634 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.323590e-01 0.634 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.323590e-01 0.634 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.696570e-01 0.569 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.696570e-01 0.569 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.696570e-01 0.569 0 0
SOS-mediated signalling R-HSA-112412 2.696570e-01 0.569 0 0
Disinhibition of SNARE formation R-HSA-114516 2.696570e-01 0.569 0 0
Axonal growth stimulation R-HSA-209563 3.979638e-01 0.400 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.979638e-01 0.400 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.226959e-01 0.652 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.226959e-01 0.652 0 0
Polymerase switching R-HSA-69091 2.226959e-01 0.652 0 0
Leading Strand Synthesis R-HSA-69109 2.226959e-01 0.652 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.226959e-01 0.652 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.226959e-01 0.652 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.226959e-01 0.652 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.226959e-01 0.652 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.226959e-01 0.652 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.226959e-01 0.652 0 0
Regulation by c-FLIP R-HSA-3371378 3.069086e-01 0.513 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.069086e-01 0.513 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.069086e-01 0.513 0 0
Dimerization of procaspase-8 R-HSA-69416 3.069086e-01 0.513 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.493572e-01 0.603 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.074721e-01 0.683 0 0
GAB1 signalosome R-HSA-180292 2.074721e-01 0.683 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.074721e-01 0.683 0 0
PKA activation in glucagon signalling R-HSA-164378 2.074721e-01 0.683 0 0
Removal of the Flap Intermediate R-HSA-69166 2.764569e-01 0.558 0 0
Lipophagy R-HSA-9613354 3.437757e-01 0.464 0 0
Calcineurin activates NFAT R-HSA-2025928 3.437757e-01 0.464 0 0
CASP8 activity is inhibited R-HSA-5218900 3.437757e-01 0.464 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 3.038225e-01 0.517 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.038225e-01 0.517 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.038225e-01 0.517 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.799858e-01 0.420 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.799858e-01 0.420 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.799858e-01 0.420 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.799858e-01 0.420 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.461827e-01 0.609 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 3.312953e-01 0.480 0 0
Translesion synthesis by POLI R-HSA-5656121 3.312953e-01 0.480 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.312953e-01 0.480 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.946388e-01 0.531 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.402317e-01 0.619 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.842227e-01 0.546 0 0
FGFR2 alternative splicing R-HSA-6803529 3.172127e-01 0.499 0 0
Notch-HLH transcription pathway R-HSA-350054 3.172127e-01 0.499 0 0
Translesion synthesis by POLK R-HSA-5655862 3.587304e-01 0.445 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.587304e-01 0.445 0 0
Activation of GABAB receptors R-HSA-991365 2.484402e-01 0.605 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.737666e-01 0.563 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.909366e-01 0.536 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.859975e-01 0.413 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.859975e-01 0.413 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.859975e-01 0.413 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.680269e-01 0.572 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.626684e-01 0.440 0 0
Deadenylation of mRNA R-HSA-429947 3.626684e-01 0.440 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.947523e-01 0.531 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.430076e-01 0.465 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.823171e-01 0.549 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.823171e-01 0.549 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.823171e-01 0.549 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.129804e-01 0.384 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.106050e-01 0.508 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.853880e-01 0.414 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.853880e-01 0.414 0 0
G protein gated Potassium channels R-HSA-1296059 3.853880e-01 0.414 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.617345e-01 0.582 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.435513e-01 0.464 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.266128e-01 0.486 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.114512e-01 0.507 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.177845e-01 0.662 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.262458e-01 0.486 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.791393e-01 0.421 0 0
HIV Transcription Initiation R-HSA-167161 3.791393e-01 0.421 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.791393e-01 0.421 0 0
Dual incision in TC-NER R-HSA-6782135 3.561669e-01 0.448 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.367479e-01 0.473 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.147744e-01 0.382 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.079045e-01 0.389 0 0
Neutrophil degranulation R-HSA-6798695 3.244835e-01 0.489 0 0
FOXO-mediated transcription R-HSA-9614085 3.288233e-01 0.483 0 0
Integrin signaling R-HSA-354192 2.080517e-01 0.682 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.725382e-01 0.565 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.653866e-01 0.437 0 0
Signaling by EGFR R-HSA-177929 3.262458e-01 0.486 0 0
GABA B receptor activation R-HSA-977444 2.484402e-01 0.605 0 0
DNA Damage Bypass R-HSA-73893 3.589694e-01 0.445 0 0
RNA Polymerase III Transcription R-HSA-74158 2.737666e-01 0.563 0 0
TGFBR3 expression R-HSA-9839394 2.096264e-01 0.679 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.189171e-01 0.660 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.823171e-01 0.549 0 0
G-protein activation R-HSA-202040 2.722836e-01 0.565 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.799858e-01 0.420 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.613206e-01 0.442 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.172127e-01 0.499 0 0
Translesion synthesis by REV1 R-HSA-110312 3.038225e-01 0.517 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.172127e-01 0.499 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.172127e-01 0.499 0 0
Nuclear RNA decay R-HSA-9930044 3.628307e-01 0.440 0 0
Attenuation phase R-HSA-3371568 3.435513e-01 0.464 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.461827e-01 0.609 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.850952e-01 0.545 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.850952e-01 0.545 0 0
Regulation of IFNG signaling R-HSA-877312 2.226959e-01 0.652 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.493572e-01 0.603 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 2.493572e-01 0.603 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.038225e-01 0.517 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.587304e-01 0.445 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.626684e-01 0.440 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.859975e-01 0.413 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.147744e-01 0.382 0 0
Cellular response to chemical stress R-HSA-9711123 3.265956e-01 0.486 0 0
Signal amplification R-HSA-392518 2.402317e-01 0.619 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.720975e-01 0.429 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.826771e-01 0.417 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.074721e-01 0.683 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.226959e-01 0.652 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.226959e-01 0.652 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.036469e-01 0.518 0 0
FasL/ CD95L signaling R-HSA-75157 3.979638e-01 0.400 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 2.286031e-01 0.641 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.764569e-01 0.558 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.312953e-01 0.480 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.568508e-01 0.590 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.539539e-01 0.595 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.725382e-01 0.565 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.080517e-01 0.682 0 0
Neurofascin interactions R-HSA-447043 2.323590e-01 0.634 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.791393e-01 0.421 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.132774e-01 0.671 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.628307e-01 0.440 0 0
Platelet sensitization by LDL R-HSA-432142 2.074721e-01 0.683 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.587304e-01 0.445 0 0
Stabilization of p53 R-HSA-69541 3.258705e-01 0.487 0 0
eNOS activation R-HSA-203615 4.024956e-01 0.395 0 0
G0 and Early G1 R-HSA-1538133 3.430076e-01 0.465 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.624664e-01 0.581 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.624664e-01 0.581 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.336482e-01 0.477 0 0
C6 deamination of adenosine R-HSA-75102 3.336482e-01 0.477 0 0
MET interacts with TNS proteins R-HSA-8875513 3.979638e-01 0.400 0 0
Signaling by LTK R-HSA-9842663 2.226959e-01 0.652 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.038225e-01 0.517 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.799858e-01 0.420 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.335229e-01 0.632 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.587304e-01 0.445 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.859975e-01 0.413 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.232611e-01 0.490 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.129804e-01 0.384 0 0
Intraflagellar transport R-HSA-5620924 3.427445e-01 0.465 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.613206e-01 0.442 0 0
Vesicle-mediated transport R-HSA-5653656 3.472841e-01 0.459 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.915785e-01 0.407 0 0
Transmission across Chemical Synapses R-HSA-112315 2.076746e-01 0.683 1 0
Neuronal System R-HSA-112316 3.851744e-01 0.414 1 0
Interleukin-6 signaling R-HSA-1059683 2.493572e-01 0.603 0 0
Protein methylation R-HSA-8876725 3.038225e-01 0.517 0 0
Signaling by TGFBR3 R-HSA-9839373 3.106050e-01 0.508 0 0
Integration of energy metabolism R-HSA-163685 3.868148e-01 0.412 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.323590e-01 0.634 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.437757e-01 0.464 0 0
Signal attenuation R-HSA-74749 3.799858e-01 0.420 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.853880e-01 0.414 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.375585e-01 0.472 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.069086e-01 0.513 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.437757e-01 0.464 0 0
Protein hydroxylation R-HSA-9629569 2.502398e-01 0.602 0 0
Interleukin-27 signaling R-HSA-9020956 3.799858e-01 0.420 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.335229e-01 0.632 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.335229e-01 0.632 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.680269e-01 0.572 0 0
Hemostasis R-HSA-109582 4.120294e-01 0.385 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.708311e-01 0.567 0 0
Immune System R-HSA-168256 2.333331e-01 0.632 1 0
Macroautophagy R-HSA-1632852 2.595466e-01 0.586 0 0
FLT3 signaling in disease R-HSA-9682385 2.737666e-01 0.563 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.947523e-01 0.531 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.947523e-01 0.531 0 0
Cardiac conduction R-HSA-5576891 3.273905e-01 0.485 1 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.142900e-01 0.669 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.529915e-01 0.597 0 0
Ion transport by P-type ATPases R-HSA-936837 3.113714e-01 0.507 1 1
Signaling by KIT in disease R-HSA-9669938 3.172127e-01 0.499 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.718640e-01 0.430 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.624664e-01 0.581 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.323590e-01 0.634 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.979638e-01 0.400 0 0
ARMS-mediated activation R-HSA-170984 3.437757e-01 0.464 0 0
Metalloprotease DUBs R-HSA-5689901 2.276884e-01 0.643 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.312953e-01 0.480 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.430076e-01 0.465 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.435513e-01 0.464 0 0
Potential therapeutics for SARS R-HSA-9679191 2.666936e-01 0.574 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.636384e-01 0.579 0 0
Signaling by TGFB family members R-HSA-9006936 3.541226e-01 0.451 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.760615e-01 0.425 0 0
Formation of definitive endoderm R-HSA-9823730 2.502398e-01 0.602 0 0
Calnexin/calreticulin cycle R-HSA-901042 2.402317e-01 0.619 0 0
Signal regulatory protein family interactions R-HSA-391160 2.764569e-01 0.558 0 0
Gluconeogenesis R-HSA-70263 2.132774e-01 0.671 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.346561e-01 0.630 0 0
Histamine receptors R-HSA-390650 3.979638e-01 0.400 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.172127e-01 0.499 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.258705e-01 0.487 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.258705e-01 0.487 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.445657e-01 0.612 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.826771e-01 0.417 0 0
FLT3 Signaling R-HSA-9607240 3.613206e-01 0.442 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.336482e-01 0.477 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.696570e-01 0.569 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.696570e-01 0.569 0 0
The NLRP1 inflammasome R-HSA-844455 3.979638e-01 0.400 0 0
Interleukin-18 signaling R-HSA-9012546 3.069086e-01 0.513 0 0
Sodium/Proton exchangers R-HSA-425986 3.069086e-01 0.513 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.799858e-01 0.420 0 0
Glucagon-type ligand receptors R-HSA-420092 2.842227e-01 0.546 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.258705e-01 0.487 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.096264e-01 0.679 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.823171e-01 0.549 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.111045e-01 0.386 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.435513e-01 0.464 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.336482e-01 0.477 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.696570e-01 0.569 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.696570e-01 0.569 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.437757e-01 0.464 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.502398e-01 0.602 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.826771e-01 0.417 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.024956e-01 0.395 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.024956e-01 0.395 0 0
Growth hormone receptor signaling R-HSA-982772 3.399171e-01 0.469 0 0
MHC class II antigen presentation R-HSA-2132295 2.348619e-01 0.629 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.502398e-01 0.602 0 0
Non-canonical inflammasome activation R-HSA-9686114 2.764569e-01 0.558 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.129290e-01 0.505 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.153224e-01 0.382 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.153224e-01 0.382 0 0
Signaling by APC mutants R-HSA-4839744 4.153224e-01 0.382 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.153224e-01 0.382 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.153224e-01 0.382 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.153224e-01 0.382 0 0
Bicarbonate transporters R-HSA-425381 4.153224e-01 0.382 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.153224e-01 0.382 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.153224e-01 0.382 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.168345e-01 0.380 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.222380e-01 0.374 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.222380e-01 0.374 0 0
Regulation of Apoptosis R-HSA-169911 4.222380e-01 0.374 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.239238e-01 0.373 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.304449e-01 0.366 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 4.304449e-01 0.366 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.304449e-01 0.366 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.317937e-01 0.365 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.325195e-01 0.364 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.395764e-01 0.357 0 0
Translesion Synthesis by POLH R-HSA-110320 4.395764e-01 0.357 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.395764e-01 0.357 0 0
The NLRP3 inflammasome R-HSA-844456 4.395764e-01 0.357 0 0
Maturation of nucleoprotein R-HSA-9694631 4.395764e-01 0.357 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.418588e-01 0.355 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.496170e-01 0.347 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.496170e-01 0.347 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.496170e-01 0.347 0 0
Signaling by AXIN mutants R-HSA-4839735 4.496170e-01 0.347 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.496170e-01 0.347 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.496170e-01 0.347 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.496170e-01 0.347 0 0
Sodium/Calcium exchangers R-HSA-425561 4.496170e-01 0.347 0 0
Activation of RAC1 R-HSA-428540 4.496170e-01 0.347 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.501713e-01 0.347 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.501713e-01 0.347 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.501713e-01 0.347 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.501713e-01 0.347 0 0
Somitogenesis R-HSA-9824272 4.501713e-01 0.347 0 0
Inflammasomes R-HSA-622312 4.526526e-01 0.344 0 0
Regulation of gap junction activity R-HSA-191650 4.560751e-01 0.341 0 0
HCN channels R-HSA-1296061 4.560751e-01 0.341 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.560751e-01 0.341 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.560751e-01 0.341 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.560751e-01 0.341 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.560751e-01 0.341 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.560751e-01 0.341 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.560751e-01 0.341 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.560751e-01 0.341 0 0
Dopamine receptors R-HSA-390651 4.560751e-01 0.341 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.560751e-01 0.341 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.560751e-01 0.341 0 0
Rab regulation of trafficking R-HSA-9007101 4.592419e-01 0.338 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.613155e-01 0.336 0 0
Degradation of DVL R-HSA-4641258 4.613155e-01 0.336 0 0
Degradation of AXIN R-HSA-4641257 4.613155e-01 0.336 0 0
Cellular response to hypoxia R-HSA-1234174 4.618997e-01 0.335 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.656961e-01 0.332 0 0
Negative regulation of MET activity R-HSA-6807004 4.656961e-01 0.332 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.676985e-01 0.330 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.676985e-01 0.330 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.676985e-01 0.330 0 0
TNF signaling R-HSA-75893 4.727168e-01 0.325 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.745694e-01 0.324 0 0
DARPP-32 events R-HSA-180024 4.745694e-01 0.324 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.745694e-01 0.324 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 4.805686e-01 0.318 0 0
Repression of WNT target genes R-HSA-4641265 4.827415e-01 0.316 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.827415e-01 0.316 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.827415e-01 0.316 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 4.827415e-01 0.316 0 0
Interleukin-35 Signalling R-HSA-8984722 4.827415e-01 0.316 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.827415e-01 0.316 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.827415e-01 0.316 0 0
OAS antiviral response R-HSA-8983711 4.827415e-01 0.316 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.833584e-01 0.316 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.850714e-01 0.314 0 0
Mitochondrial protein degradation R-HSA-9837999 4.860332e-01 0.313 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.886717e-01 0.311 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.912623e-01 0.309 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.912623e-01 0.309 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.912623e-01 0.309 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.912623e-01 0.309 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.916744e-01 0.308 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.961444e-01 0.304 0 0
Interleukin-37 signaling R-HSA-9008059 4.961444e-01 0.304 0 0
Metabolism of proteins R-HSA-392499 4.988966e-01 0.302 0 0
Transcription of the HIV genome R-HSA-167172 5.063911e-01 0.296 0 0
PCP/CE pathway R-HSA-4086400 5.080782e-01 0.294 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.085804e-01 0.294 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.085804e-01 0.294 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.085804e-01 0.294 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.085804e-01 0.294 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.085804e-01 0.294 0 0
Reelin signalling pathway R-HSA-8866376 5.085804e-01 0.294 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.085804e-01 0.294 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.085804e-01 0.294 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.085804e-01 0.294 0 0
Co-inhibition by BTLA R-HSA-9927353 5.085804e-01 0.294 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.085804e-01 0.294 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.146023e-01 0.289 0 0
Formation of axial mesoderm R-HSA-9796292 5.146023e-01 0.289 0 0
Frs2-mediated activation R-HSA-170968 5.146023e-01 0.289 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.146023e-01 0.289 0 0
Maturation of nucleoprotein R-HSA-9683610 5.146023e-01 0.289 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.146023e-01 0.289 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.146023e-01 0.289 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.162097e-01 0.287 0 0
Assembly Of The HIV Virion R-HSA-175474 5.162097e-01 0.287 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.173324e-01 0.286 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.173324e-01 0.286 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.183213e-01 0.285 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.183213e-01 0.285 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.192455e-01 0.285 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.192455e-01 0.285 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.192455e-01 0.285 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.192455e-01 0.285 0 0
Signaling by MET R-HSA-6806834 5.353633e-01 0.271 0 0
ER-Phagosome pathway R-HSA-1236974 5.354369e-01 0.271 0 0
GABA receptor activation R-HSA-977443 5.355847e-01 0.271 0 0
Platelet homeostasis R-HSA-418346 5.357986e-01 0.271 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 5.367572e-01 0.270 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.367572e-01 0.270 0 0
Signaling by WNT in cancer R-HSA-4791275 5.380933e-01 0.269 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.380933e-01 0.269 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.404838e-01 0.267 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.404838e-01 0.267 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.451349e-01 0.263 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.451349e-01 0.263 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.451349e-01 0.263 0 0
Regulation of KIT signaling R-HSA-1433559 5.451349e-01 0.263 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.451349e-01 0.263 0 0
HDL assembly R-HSA-8963896 5.451349e-01 0.263 0 0
Downstream TCR signaling R-HSA-202424 5.481770e-01 0.261 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.508407e-01 0.259 0 0
The phototransduction cascade R-HSA-2514856 5.524950e-01 0.258 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.548620e-01 0.256 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.548620e-01 0.256 0 0
Translation of Structural Proteins R-HSA-9683701 5.548620e-01 0.256 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.560201e-01 0.255 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.560201e-01 0.255 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.560201e-01 0.255 0 0
TRAIL signaling R-HSA-75158 5.560201e-01 0.255 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.560201e-01 0.255 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.560201e-01 0.255 0 0
Cam-PDE 1 activation R-HSA-111957 5.560201e-01 0.255 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.560201e-01 0.255 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.560201e-01 0.255 0 0
Intestinal hexose absorption R-HSA-8981373 5.560201e-01 0.255 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 5.560201e-01 0.255 0 0
Signaling by MST1 R-HSA-8852405 5.560201e-01 0.255 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.560201e-01 0.255 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.560201e-01 0.255 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.583923e-01 0.253 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.583923e-01 0.253 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.583923e-01 0.253 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.658768e-01 0.247 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.687195e-01 0.245 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.726113e-01 0.242 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.726113e-01 0.242 0 0
Erythropoietin activates RAS R-HSA-9027284 5.742987e-01 0.241 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.742987e-01 0.241 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.742987e-01 0.241 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.742987e-01 0.241 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.742987e-01 0.241 0 0
p75NTR signals via NF-kB R-HSA-193639 5.742987e-01 0.241 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.742987e-01 0.241 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.742987e-01 0.241 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.742987e-01 0.241 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.781993e-01 0.238 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.781993e-01 0.238 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.781993e-01 0.238 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.806779e-01 0.236 0 0
Signaling by PTK6 R-HSA-8848021 5.806779e-01 0.236 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.868438e-01 0.231 0 0
Interleukin-6 family signaling R-HSA-6783589 5.868438e-01 0.231 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.868438e-01 0.231 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.899837e-01 0.229 0 0
Signaling by ERBB4 R-HSA-1236394 5.912873e-01 0.228 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.952298e-01 0.225 0 0
Signaling by NOTCH2 R-HSA-1980145 5.974890e-01 0.224 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.974890e-01 0.224 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.988827e-01 0.223 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.988827e-01 0.223 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.988827e-01 0.223 0 0
STAT5 Activation R-HSA-9645135 5.988827e-01 0.223 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 5.988827e-01 0.223 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 5.988827e-01 0.223 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.988827e-01 0.223 0 0
Lactose synthesis R-HSA-5653890 5.988827e-01 0.223 0 0
VLDL assembly R-HSA-8866423 5.988827e-01 0.223 0 0
HDL clearance R-HSA-8964011 5.988827e-01 0.223 0 0
MET Receptor Activation R-HSA-6806942 5.988827e-01 0.223 0 0
Nef and signal transduction R-HSA-164944 5.988827e-01 0.223 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.002773e-01 0.222 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.020734e-01 0.220 0 0
Prolonged ERK activation events R-HSA-169893 6.020734e-01 0.220 0 0
Regulation of BACH1 activity R-HSA-9708530 6.020734e-01 0.220 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.020734e-01 0.220 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.020734e-01 0.220 0 0
Activation of SMO R-HSA-5635838 6.020734e-01 0.220 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.020734e-01 0.220 0 0
Virus Assembly and Release R-HSA-168268 6.020734e-01 0.220 0 0
Amine ligand-binding receptors R-HSA-375280 6.069603e-01 0.217 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.088677e-01 0.215 0 0
Oncogene Induced Senescence R-HSA-2559585 6.162405e-01 0.210 0 0
Signaling by NOTCH1 R-HSA-1980143 6.179683e-01 0.209 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.235250e-01 0.205 0 0
Disease R-HSA-1643685 6.271006e-01 0.203 1 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.284556e-01 0.202 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.284556e-01 0.202 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.284556e-01 0.202 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.284556e-01 0.202 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.284556e-01 0.202 0 0
Coenzyme A biosynthesis R-HSA-196783 6.284556e-01 0.202 0 0
Passive transport by Aquaporins R-HSA-432047 6.284556e-01 0.202 0 0
Synthesis of PG R-HSA-1483148 6.284556e-01 0.202 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.284556e-01 0.202 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.300928e-01 0.201 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.300928e-01 0.201 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.300928e-01 0.201 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.305479e-01 0.200 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.344370e-01 0.198 0 0
RUNX2 regulates bone development R-HSA-8941326 6.344370e-01 0.198 0 0
GPVI-mediated activation cascade R-HSA-114604 6.344370e-01 0.198 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.376095e-01 0.195 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.376095e-01 0.195 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.376095e-01 0.195 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.376095e-01 0.195 0 0
Recycling of eIF2:GDP R-HSA-72731 6.376095e-01 0.195 0 0
PTK6 Expression R-HSA-8849473 6.376095e-01 0.195 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.376095e-01 0.195 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.376095e-01 0.195 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.376095e-01 0.195 0 0
VLDL clearance R-HSA-8964046 6.376095e-01 0.195 0 0
LDL remodeling R-HSA-8964041 6.376095e-01 0.195 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.376095e-01 0.195 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.376095e-01 0.195 0 0
Regulation of PTEN localization R-HSA-8948747 6.376095e-01 0.195 0 0
Netrin mediated repulsion signals R-HSA-418886 6.376095e-01 0.195 0 0
Integrin cell surface interactions R-HSA-216083 6.436977e-01 0.191 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.505066e-01 0.187 0 0
Cristae formation R-HSA-8949613 6.505066e-01 0.187 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.505066e-01 0.187 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.505066e-01 0.187 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.505066e-01 0.187 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.505066e-01 0.187 0 0
Insulin processing R-HSA-264876 6.505066e-01 0.187 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.520653e-01 0.186 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.534550e-01 0.185 0 0
Choline catabolism R-HSA-6798163 6.534550e-01 0.185 0 0
Specification of primordial germ cells R-HSA-9827857 6.534550e-01 0.185 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.553673e-01 0.184 0 0
Interferon alpha/beta signaling R-HSA-909733 6.567323e-01 0.183 0 0
MET promotes cell motility R-HSA-8875878 6.691162e-01 0.174 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.691162e-01 0.174 0 0
Elastic fibre formation R-HSA-1566948 6.691162e-01 0.174 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.701028e-01 0.174 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.701028e-01 0.174 0 0
HIV elongation arrest and recovery R-HSA-167287 6.701028e-01 0.174 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.701028e-01 0.174 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.701028e-01 0.174 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.716695e-01 0.173 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.718381e-01 0.173 0 0
phospho-PLA2 pathway R-HSA-111995 6.725995e-01 0.172 0 0
DAG1 core M2 glycosylations R-HSA-8932504 6.725995e-01 0.172 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.725995e-01 0.172 0 0
MET receptor recycling R-HSA-8875656 6.725995e-01 0.172 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.725995e-01 0.172 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.725995e-01 0.172 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.725995e-01 0.172 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.725995e-01 0.172 0 0
Co-stimulation by ICOS R-HSA-9927354 6.725995e-01 0.172 0 0
Interleukin-9 signaling R-HSA-8985947 6.725995e-01 0.172 0 0
Adrenoceptors R-HSA-390696 6.725995e-01 0.172 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.725995e-01 0.172 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.725995e-01 0.172 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.725995e-01 0.172 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.725995e-01 0.172 0 0
Intestinal absorption R-HSA-8963676 6.725995e-01 0.172 0 0
Interleukin-23 signaling R-HSA-9020933 6.725995e-01 0.172 0 0
Extension of Telomeres R-HSA-180786 6.733414e-01 0.172 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.733414e-01 0.172 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.770928e-01 0.169 0 0
Polo-like kinase mediated events R-HSA-156711 6.770928e-01 0.169 0 0
Tie2 Signaling R-HSA-210993 6.770928e-01 0.169 0 0
Nephron development R-HSA-9831926 6.770928e-01 0.169 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.855833e-01 0.164 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.855833e-01 0.164 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.868768e-01 0.163 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.868768e-01 0.163 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.868768e-01 0.163 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.868768e-01 0.163 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.868768e-01 0.163 0 0
tRNA Aminoacylation R-HSA-379724 6.868768e-01 0.163 0 0
ABC-family proteins mediated transport R-HSA-382556 6.881825e-01 0.162 0 0
Signaling by Erythropoietin R-HSA-9006335 6.888807e-01 0.162 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.888807e-01 0.162 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.888807e-01 0.162 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.888807e-01 0.162 0 0
Platelet calcium homeostasis R-HSA-418360 6.888807e-01 0.162 0 0
Hedgehog 'on' state R-HSA-5632684 6.892121e-01 0.162 0 0
SLC transporter disorders R-HSA-5619102 6.913459e-01 0.160 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.993988e-01 0.155 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.993988e-01 0.155 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.993988e-01 0.155 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.993988e-01 0.155 0 0
Regulation of signaling by CBL R-HSA-912631 6.993988e-01 0.155 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.997787e-01 0.155 0 0
PI3K Cascade R-HSA-109704 6.997787e-01 0.155 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.014637e-01 0.154 0 0
HIV Transcription Elongation R-HSA-167169 7.014637e-01 0.154 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.014637e-01 0.154 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.034821e-01 0.153 0 0
ALK mutants bind TKIs R-HSA-9700645 7.042129e-01 0.152 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.042129e-01 0.152 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.042129e-01 0.152 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.042129e-01 0.152 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.042129e-01 0.152 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.042129e-01 0.152 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.042129e-01 0.152 0 0
Interleukin-21 signaling R-HSA-9020958 7.042129e-01 0.152 0 0
mRNA Editing R-HSA-75072 7.042129e-01 0.152 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.042129e-01 0.152 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.042129e-01 0.152 0 0
WNT mediated activation of DVL R-HSA-201688 7.042129e-01 0.152 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.042129e-01 0.152 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.042129e-01 0.152 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.042129e-01 0.152 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.042129e-01 0.152 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.042129e-01 0.152 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.068439e-01 0.151 0 0
DAP12 signaling R-HSA-2424491 7.068439e-01 0.151 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.068439e-01 0.151 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.068439e-01 0.151 0 0
Mitochondrial protein import R-HSA-1268020 7.128234e-01 0.147 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 7.136677e-01 0.147 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.167568e-01 0.145 0 0
Maturation of spike protein R-HSA-9694548 7.167568e-01 0.145 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.204098e-01 0.142 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.204098e-01 0.142 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.204098e-01 0.142 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.204098e-01 0.142 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.204098e-01 0.142 0 0
Signaling by NODAL R-HSA-1181150 7.204098e-01 0.142 0 0
Creatine metabolism R-HSA-71288 7.204098e-01 0.142 0 0
tRNA processing R-HSA-72306 7.229416e-01 0.141 0 0
EGFR downregulation R-HSA-182971 7.240005e-01 0.140 0 0
Budding and maturation of HIV virion R-HSA-162588 7.240005e-01 0.140 0 0
Downstream signal transduction R-HSA-186763 7.240005e-01 0.140 0 0
Signaling by FGFR in disease R-HSA-1226099 7.248714e-01 0.140 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.270960e-01 0.138 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.314647e-01 0.136 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.314647e-01 0.136 0 0
Binding and entry of HIV virion R-HSA-173107 7.327754e-01 0.135 0 0
Metabolism of serotonin R-HSA-380612 7.327754e-01 0.135 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.327754e-01 0.135 0 0
Pexophagy R-HSA-9664873 7.327754e-01 0.135 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.327754e-01 0.135 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.360568e-01 0.133 0 0
Interleukin-1 family signaling R-HSA-446652 7.400464e-01 0.131 0 0
Nucleotide biosynthesis R-HSA-8956320 7.400642e-01 0.131 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.401678e-01 0.131 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 7.401678e-01 0.131 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.401678e-01 0.131 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.401678e-01 0.131 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.403620e-01 0.131 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.517366e-01 0.124 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.559430e-01 0.122 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.559925e-01 0.121 0 0
Translation of Structural Proteins R-HSA-9694635 7.576235e-01 0.121 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.585814e-01 0.120 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.585814e-01 0.120 0 0
LGI-ADAM interactions R-HSA-5682910 7.585814e-01 0.120 0 0
vRNA Synthesis R-HSA-192814 7.585814e-01 0.120 0 0
vRNP Assembly R-HSA-192905 7.585814e-01 0.120 0 0
Chylomicron assembly R-HSA-8963888 7.585814e-01 0.120 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.585814e-01 0.120 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.585814e-01 0.120 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.587188e-01 0.120 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.587188e-01 0.120 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.587188e-01 0.120 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.587188e-01 0.120 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.587188e-01 0.120 0 0
Ribavirin ADME R-HSA-9755088 7.587188e-01 0.120 0 0
TBC/RABGAPs R-HSA-8854214 7.591439e-01 0.120 0 0
ABC transporter disorders R-HSA-5619084 7.678935e-01 0.115 0 0
Netrin-1 signaling R-HSA-373752 7.721295e-01 0.112 0 0
G1 Phase R-HSA-69236 7.721295e-01 0.112 0 0
Cyclin D associated events in G1 R-HSA-69231 7.721295e-01 0.112 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.761117e-01 0.110 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.761117e-01 0.110 0 0
Ethanol oxidation R-HSA-71384 7.761117e-01 0.110 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.761117e-01 0.110 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.818966e-01 0.107 0 0
NF-kB is activated and signals survival R-HSA-209560 7.818966e-01 0.107 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.818966e-01 0.107 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.818966e-01 0.107 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.848339e-01 0.105 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.848339e-01 0.105 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.848339e-01 0.105 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.848339e-01 0.105 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.848339e-01 0.105 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.848339e-01 0.105 0 0
IRS-mediated signalling R-HSA-112399 7.873952e-01 0.104 0 0
Signaling by FGFR2 R-HSA-5654738 7.874713e-01 0.104 0 0
Post-translational protein modification R-HSA-597592 7.891213e-01 0.103 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.902136e-01 0.102 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.902136e-01 0.102 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.923970e-01 0.101 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.923970e-01 0.101 0 0
Interleukin-20 family signaling R-HSA-8854691 7.923970e-01 0.101 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.923970e-01 0.101 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.923970e-01 0.101 0 0
Biosynthesis of maresins R-HSA-9018682 7.923970e-01 0.101 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.964402e-01 0.099 0 0
Diseases of DNA repair R-HSA-9675135 7.964402e-01 0.099 0 0
PERK regulates gene expression R-HSA-381042 7.981841e-01 0.098 0 0
Signalling to ERKs R-HSA-187687 7.981841e-01 0.098 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.981841e-01 0.098 0 0
Interleukin-1 signaling R-HSA-9020702 7.997468e-01 0.097 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.029614e-01 0.095 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.029614e-01 0.095 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.029614e-01 0.095 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.029614e-01 0.095 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.029614e-01 0.095 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.029614e-01 0.095 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.029614e-01 0.095 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.029614e-01 0.095 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.029614e-01 0.095 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.036027e-01 0.095 0 0
G alpha (s) signalling events R-HSA-418555 8.044149e-01 0.095 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.044149e-01 0.095 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.076265e-01 0.093 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.076265e-01 0.093 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.076265e-01 0.093 0 0
Complex III assembly R-HSA-9865881 8.076265e-01 0.093 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.077883e-01 0.093 0 0
Regulation of beta-cell development R-HSA-186712 8.084100e-01 0.092 0 0
Triglyceride catabolism R-HSA-163560 8.108335e-01 0.091 0 0
G1/S-Specific Transcription R-HSA-69205 8.108335e-01 0.091 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.165167e-01 0.088 0 0
Metabolism of polyamines R-HSA-351202 8.182802e-01 0.087 0 0
NGF-stimulated transcription R-HSA-9031628 8.186150e-01 0.087 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.218520e-01 0.085 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.218520e-01 0.085 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.218520e-01 0.085 0 0
Laminin interactions R-HSA-3000157 8.218520e-01 0.085 0 0
Tight junction interactions R-HSA-420029 8.218520e-01 0.085 0 0
Hyaluronan degradation R-HSA-2160916 8.218520e-01 0.085 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.218520e-01 0.085 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.219928e-01 0.085 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.219928e-01 0.085 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.219928e-01 0.085 0 0
Processing of SMDT1 R-HSA-8949664 8.219928e-01 0.085 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.219928e-01 0.085 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.277371e-01 0.082 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.341245e-01 0.079 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.341245e-01 0.079 0 0
MET activates PTK2 signaling R-HSA-8874081 8.351255e-01 0.078 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.351255e-01 0.078 0 0
TRP channels R-HSA-3295583 8.351255e-01 0.078 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.351255e-01 0.078 0 0
Signaling by PDGF R-HSA-186797 8.367905e-01 0.077 0 0
Heme signaling R-HSA-9707616 8.367905e-01 0.077 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.373826e-01 0.077 0 0
Azathioprine ADME R-HSA-9748787 8.387609e-01 0.076 0 0
cGMP effects R-HSA-418457 8.391871e-01 0.076 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.391871e-01 0.076 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.391871e-01 0.076 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.391871e-01 0.076 0 0
Hydrolysis of LPC R-HSA-1483115 8.391871e-01 0.076 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.391871e-01 0.076 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.391871e-01 0.076 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.391871e-01 0.076 0 0
Physiological factors R-HSA-5578768 8.391871e-01 0.076 0 0
Prolactin receptor signaling R-HSA-1170546 8.391871e-01 0.076 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.391871e-01 0.076 0 0
Malate-aspartate shuttle R-HSA-9856872 8.391871e-01 0.076 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.391871e-01 0.076 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.391871e-01 0.076 0 0
RAS processing R-HSA-9648002 8.448150e-01 0.073 0 0
Signaling by ALK R-HSA-201556 8.448150e-01 0.073 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.448150e-01 0.073 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.474980e-01 0.072 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 8.474980e-01 0.072 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.514931e-01 0.070 0 0
IGF1R signaling cascade R-HSA-2428924 8.537265e-01 0.069 0 0
Insulin receptor signalling cascade R-HSA-74751 8.537265e-01 0.069 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.538031e-01 0.069 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.546210e-01 0.068 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.547214e-01 0.068 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.547214e-01 0.068 0 0
DCC mediated attractive signaling R-HSA-418885 8.547214e-01 0.068 0 0
Protein lipoylation R-HSA-9857492 8.547214e-01 0.068 0 0
p38MAPK events R-HSA-171007 8.547214e-01 0.068 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.547214e-01 0.068 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.547214e-01 0.068 0 0
Other semaphorin interactions R-HSA-416700 8.547214e-01 0.068 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.547214e-01 0.068 0 0
DNA Damage Reversal R-HSA-73942 8.547214e-01 0.068 0 0
Diseases of Immune System R-HSA-5260271 8.549022e-01 0.068 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.549022e-01 0.068 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.569955e-01 0.067 0 0
Signaling by NTRKs R-HSA-166520 8.582757e-01 0.066 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.590198e-01 0.066 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.590198e-01 0.066 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.616304e-01 0.065 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.644113e-01 0.063 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.680623e-01 0.061 0 0
Phosphorylation of the APC/C R-HSA-176412 8.687560e-01 0.061 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.687560e-01 0.061 0 0
Atorvastatin ADME R-HSA-9754706 8.687560e-01 0.061 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.687560e-01 0.061 0 0
Fructose catabolism R-HSA-70350 8.687560e-01 0.061 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.687560e-01 0.061 0 0
Differentiation of T cells R-HSA-9945266 8.687560e-01 0.061 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.687560e-01 0.061 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.687560e-01 0.061 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.687560e-01 0.061 0 0
Negative regulation of FLT3 R-HSA-9706369 8.687560e-01 0.061 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.691728e-01 0.061 0 0
mRNA Capping R-HSA-72086 8.697396e-01 0.061 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.697396e-01 0.061 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.697396e-01 0.061 0 0
Intra-Golgi traffic R-HSA-6811438 8.733674e-01 0.059 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.733674e-01 0.059 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.758288e-01 0.058 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.797049e-01 0.056 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.797049e-01 0.056 0 0
Neurotransmitter clearance R-HSA-112311 8.797049e-01 0.056 0 0
Glycine degradation R-HSA-6783984 8.814355e-01 0.055 0 0
Fibronectin matrix formation R-HSA-1566977 8.814355e-01 0.055 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.814355e-01 0.055 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.814355e-01 0.055 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.814355e-01 0.055 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.814355e-01 0.055 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.814355e-01 0.055 0 0
Regulated Necrosis R-HSA-5218859 8.832176e-01 0.054 0 0
Circadian clock R-HSA-9909396 8.835165e-01 0.054 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.882299e-01 0.051 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.889613e-01 0.051 0 0
Signaling by FGFR4 R-HSA-5654743 8.897200e-01 0.051 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.911891e-01 0.050 0 0
Formation of the cornified envelope R-HSA-6809371 8.917636e-01 0.050 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.928907e-01 0.049 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 8.928907e-01 0.049 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.928907e-01 0.049 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.928907e-01 0.049 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.928907e-01 0.049 0 0
Ion channel transport R-HSA-983712 8.945706e-01 0.048 1 0
Synthesis of PA R-HSA-1483166 8.950406e-01 0.048 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.958543e-01 0.048 0 0
DAP12 interactions R-HSA-2172127 8.971653e-01 0.047 0 0
DAG1 glycosylations R-HSA-8931838 8.975528e-01 0.047 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.975528e-01 0.047 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.017939e-01 0.045 0 0
ECM proteoglycans R-HSA-3000178 9.018553e-01 0.045 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.032398e-01 0.044 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 9.032398e-01 0.044 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.032398e-01 0.044 0 0
Signaling by FGFR3 R-HSA-5654741 9.041549e-01 0.044 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.055214e-01 0.043 0 0
Cardiogenesis R-HSA-9733709 9.055214e-01 0.043 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.067579e-01 0.043 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.075750e-01 0.042 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.107121e-01 0.041 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.107121e-01 0.041 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.107121e-01 0.041 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.107761e-01 0.041 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.125894e-01 0.040 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.125894e-01 0.040 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.125894e-01 0.040 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.125894e-01 0.040 0 0
Specification of the neural plate border R-HSA-9834899 9.125894e-01 0.040 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.125894e-01 0.040 0 0
Other interleukin signaling R-HSA-449836 9.125894e-01 0.040 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.125894e-01 0.040 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.129072e-01 0.040 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.129072e-01 0.040 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.133295e-01 0.039 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 9.136131e-01 0.039 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.168592e-01 0.038 0 0
Synthesis of PC R-HSA-1483191 9.168592e-01 0.038 0 0
Stimuli-sensing channels R-HSA-2672351 9.187145e-01 0.037 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.197485e-01 0.036 0 0
Mitophagy R-HSA-5205647 9.197485e-01 0.036 0 0
Hyaluronan metabolism R-HSA-2142845 9.197485e-01 0.036 0 0
Extracellular matrix organization R-HSA-1474244 9.197554e-01 0.036 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.197680e-01 0.036 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.197680e-01 0.036 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.210362e-01 0.036 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.210362e-01 0.036 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.210362e-01 0.036 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.210362e-01 0.036 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.210362e-01 0.036 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.210362e-01 0.036 0 0
Pyruvate metabolism R-HSA-70268 9.230790e-01 0.035 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.238879e-01 0.034 0 0
Signaling by FGFR R-HSA-190236 9.245201e-01 0.034 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.260814e-01 0.033 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.260814e-01 0.033 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.260814e-01 0.033 0 0
Adipogenesis R-HSA-9843745 9.282955e-01 0.032 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.286672e-01 0.032 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.286672e-01 0.032 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.286672e-01 0.032 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.286672e-01 0.032 0 0
Signalling to RAS R-HSA-167044 9.286672e-01 0.032 0 0
Phenylalanine metabolism R-HSA-8964208 9.286672e-01 0.032 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.286672e-01 0.032 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.286672e-01 0.032 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.287209e-01 0.032 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.319403e-01 0.031 0 0
Parasitic Infection Pathways R-HSA-9824443 9.344250e-01 0.029 0 0
Leishmania infection R-HSA-9658195 9.344250e-01 0.029 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.351973e-01 0.029 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.355611e-01 0.029 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.355611e-01 0.029 0 0
Glutathione synthesis and recycling R-HSA-174403 9.355611e-01 0.029 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.355611e-01 0.029 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.356845e-01 0.029 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.366540e-01 0.028 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.373576e-01 0.028 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.385265e-01 0.028 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.417891e-01 0.026 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.417891e-01 0.026 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.417891e-01 0.026 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.417891e-01 0.026 0 0
Cellular hexose transport R-HSA-189200 9.417891e-01 0.026 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.417891e-01 0.026 0 0
Fructose metabolism R-HSA-5652084 9.417891e-01 0.026 0 0
LDL clearance R-HSA-8964038 9.417891e-01 0.026 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.417891e-01 0.026 0 0
Kidney development R-HSA-9830369 9.453983e-01 0.024 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.465338e-01 0.024 0 0
G alpha (q) signalling events R-HSA-416476 9.469215e-01 0.024 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.469882e-01 0.024 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.469882e-01 0.024 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.474155e-01 0.023 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.474155e-01 0.023 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.474155e-01 0.023 0 0
Formation of the ureteric bud R-HSA-9830674 9.474155e-01 0.023 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.474155e-01 0.023 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.474155e-01 0.023 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.474155e-01 0.023 0 0
RSV-host interactions R-HSA-9833110 9.485831e-01 0.023 0 0
Gastrulation R-HSA-9758941 9.504618e-01 0.022 0 0
Interleukin-2 family signaling R-HSA-451927 9.512574e-01 0.022 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.512574e-01 0.022 0 0
Collagen formation R-HSA-1474290 9.516628e-01 0.022 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.524984e-01 0.021 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.528714e-01 0.021 0 0
Mitochondrial biogenesis R-HSA-1592230 9.543026e-01 0.020 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.551969e-01 0.020 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.564866e-01 0.019 0 0
Signaling by FGFR1 R-HSA-5654736 9.570639e-01 0.019 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.570903e-01 0.019 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.570903e-01 0.019 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.570903e-01 0.019 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.570903e-01 0.019 0 0
Formation of the nephric duct R-HSA-9830364 9.570903e-01 0.019 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.570903e-01 0.019 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.588305e-01 0.018 0 0
Potassium Channels R-HSA-1296071 9.596296e-01 0.018 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.612068e-01 0.017 0 0
Urea cycle R-HSA-70635 9.612385e-01 0.017 0 0
Sphingolipid catabolism R-HSA-9845614 9.612385e-01 0.017 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.612385e-01 0.017 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.621806e-01 0.017 0 0
Toll-like Receptor Cascades R-HSA-168898 9.630264e-01 0.016 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.630813e-01 0.016 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.635380e-01 0.016 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.649859e-01 0.015 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.649859e-01 0.015 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.649859e-01 0.015 0 0
Triglyceride metabolism R-HSA-8979227 9.657834e-01 0.015 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.658497e-01 0.015 0 0
RAB geranylgeranylation R-HSA-8873719 9.682981e-01 0.014 0 0
Telomere Extension By Telomerase R-HSA-171319 9.683712e-01 0.014 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.683712e-01 0.014 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.683712e-01 0.014 0 0
Prednisone ADME R-HSA-9757110 9.683712e-01 0.014 0 0
Pyroptosis R-HSA-5620971 9.683712e-01 0.014 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.685340e-01 0.014 0 0
MAP kinase activation R-HSA-450294 9.706374e-01 0.013 0 0
G alpha (i) signalling events R-HSA-418594 9.714122e-01 0.013 1 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.714294e-01 0.013 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.714294e-01 0.013 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.714294e-01 0.013 0 0
PI Metabolism R-HSA-1483255 9.720886e-01 0.012 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.728126e-01 0.012 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.741921e-01 0.011 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.763063e-01 0.010 0 0
Cargo concentration in the ER R-HSA-5694530 9.766877e-01 0.010 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.766877e-01 0.010 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.766877e-01 0.010 0 0
Signaling by Insulin receptor R-HSA-74752 9.770235e-01 0.010 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.770235e-01 0.010 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.776504e-01 0.010 0 0
Parasite infection R-HSA-9664407 9.776504e-01 0.010 0 0
Leishmania phagocytosis R-HSA-9664417 9.776504e-01 0.010 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.785170e-01 0.009 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.792784e-01 0.009 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.809788e-01 0.008 0 0
Recycling of bile acids and salts R-HSA-159418 9.809788e-01 0.008 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.810036e-01 0.008 0 0
Complex IV assembly R-HSA-9864848 9.825890e-01 0.008 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.828185e-01 0.008 0 0
Heme degradation R-HSA-189483 9.828185e-01 0.008 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.829738e-01 0.007 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.836290e-01 0.007 0 0
RA biosynthesis pathway R-HSA-5365859 9.844803e-01 0.007 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.844803e-01 0.007 0 0
Neddylation R-HSA-8951664 9.845294e-01 0.007 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.853835e-01 0.006 0 0
Interleukin-17 signaling R-HSA-448424 9.854652e-01 0.006 0 0
Metabolism of cofactors R-HSA-8978934 9.865758e-01 0.006 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.867562e-01 0.006 0 0
HS-GAG biosynthesis R-HSA-2022928 9.873377e-01 0.006 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.873377e-01 0.006 0 0
Paracetamol ADME R-HSA-9753281 9.877395e-01 0.005 0 0
GPCR downstream signalling R-HSA-388396 9.881753e-01 0.005 1 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.884871e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.885626e-01 0.005 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.885626e-01 0.005 0 0
Lysine catabolism R-HSA-71064 9.885626e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.885626e-01 0.005 0 0
Metabolism of folate and pterines R-HSA-196757 9.885626e-01 0.005 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.894073e-01 0.005 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.896692e-01 0.005 0 0
Protein localization R-HSA-9609507 9.899945e-01 0.004 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.900909e-01 0.004 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.905946e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.906687e-01 0.004 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.913933e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.915716e-01 0.004 0 0
Glycogen metabolism R-HSA-8982491 9.915716e-01 0.004 0 0
Tryptophan catabolism R-HSA-71240 9.915716e-01 0.004 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.917100e-01 0.004 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.923561e-01 0.003 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.934269e-01 0.003 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.938829e-01 0.003 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.944913e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.949333e-01 0.002 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.953994e-01 0.002 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.953994e-01 0.002 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.953994e-01 0.002 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.954220e-01 0.002 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.957933e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.966282e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.966753e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.969547e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.970548e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.970695e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.973237e-01 0.001 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.974616e-01 0.001 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.974616e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.975561e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.978139e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.979630e-01 0.001 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.979718e-01 0.001 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.979718e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.983064e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.983393e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.984512e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.985841e-01 0.001 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.986243e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.986518e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.986696e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.988039e-01 0.001 1 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.988237e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.989004e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.989004e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.989698e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.990069e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.990069e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.990525e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.991031e-01 0.000 0 0
Keratinization R-HSA-6805567 9.992098e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.992222e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.992685e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.992685e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.993063e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.993394e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.995134e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.995720e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.996017e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996194e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.996319e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.996417e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.996764e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.996781e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997078e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.997293e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.997361e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.997585e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.997617e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997784e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.997848e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998009e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998162e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.998569e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998851e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999139e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999141e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999406e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.999580e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999641e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999772e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999870e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999894e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999897e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999901e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999909e-01 0.000 1 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999940e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999946e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999950e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999956e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999975e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999977e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999977e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999987e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999993e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999995e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999996e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999997e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999998e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways