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Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O00458 S15 Sugiyama IFRD1 ______MPKNKKRNtPHRGssAGGGGsGAAAATAATAGGQH
O00488 S93 Sugiyama ZNF593 ZT86 STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O14908 S232 Sugiyama GIPC1 C19orf3 GIPC RGS19IP1 TEPRKAFDMISQRsAGGRPGsGPQLGtGRGtLRLRsRGPAt
O43143 S656 Sugiyama DHX15 DBP1 DDX15 QNHESVQWCYDNFINYRSLMsADNVRQQLSRIMDRFNLPRR
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60573 S74 Sugiyama EIF4E2 EIF4EL3 HPLQYNYTFWYSRRtPGRPtsSQSyEQNIKQIGTFASVEQF
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75122 S22 Sugiyama CLASP2 KIAA0627 AMGDDKsFDDEEsVDGNRPssAAsAFKVPAPKTSGNPANSA
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O75822 T33 Sugiyama EIF3J EIF3S1 PRO0391 sWDADAFsVEDPVRKVGGGGtAGGDRWEGEDEDEDVKDNWD
O95218 S65 Sugiyama ZRANB2 ZIS ZNF265 MKAGGtEIGKtLAEKSRGLFsANDWQCKTCsNVNWARRsEC
P00966 T219 Sugiyama ASS1 ASS KNQAPPGLytKtQDPAKAPNtPDILEIEFKKGVPVKVTNVK
P04040 T28 Sugiyama CAT ASDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRG
P04040 T434 Sugiyama CAT QQPSALEHSIQYSGEVRRFNtANDDNVtQVRAFyVNVLNEE
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04181 T39 Sugiyama OAT HSSVASATSVATKKtVQGPPtSDDIFEREyKyGAHNyHPLP
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 T174 Sugiyama HSPB1 HSP27 HSP28 SSsLsPEGtLTVEAPMPKLAtQsNEItIPVtFEsRAQLGGP
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05783 S30 Sugiyama KRT18 CYK18 PIG46 stNyRsLGsVQAPsyGARPVssAAsVyAGAGGsGsRIsVsR
P05783 S31 Sugiyama KRT18 CYK18 PIG46 tNyRsLGsVQAPsyGARPVssAAsVyAGAGGsGsRIsVsRs
P06493 T47 Sugiyama CDK1 CDC2 CDC28A CDKN1 P34CDC2 GQVVAMKKIRLEsEEEGVPstAIREIsLLKELRHPNIVSLQ
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07437 S172 Sugiyama TUBB TUBB5 OK/SW-cl.56 ISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLSVHQL
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437 T166 Sugiyama TUBB TUBB5 OK/SW-cl.56 GMGTLLISKIREEYPDRIMNtFsVVPsPKVSDTVVEPYNAT
P08174 S106 Sugiyama CD55 CR DAF QWSDIEEFCNRSCEVPtRLNsAsLKQPYITQNyFPVGtVVE
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08865 T97 Sugiyama RPSA LAMBR LAMR1 IssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQAAFR
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7 T56 Sugiyama TUBA3C TUBA2 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
P10809 S70 Sugiyama HSPD1 HSP60 AVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKY
P11142 T222 Sugiyama HSPA8 HSC70 HSP73 HSPA10 GGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFI
P11142 T38 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11586 T148 Sugiyama MTHFD1 MTHFC MTHFD tsINAGKLARGDLNDCFIPCtPKGCLELIKETGVPIAGRHA
P12270 S648 Sugiyama TPR LHAssLDDVsLAstPKRPstsQtVstPAPVPVIESTEAIEA
P12270 T650 Sugiyama TPR AssLDDVsLAstPKRPstsQtVstPAPVPVIESTEAIEAKA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13639 T735 Sugiyama EEF2 EF2 HRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCPEQV
P13929 S14 Sugiyama ENO3 _______MAMQKIFAREILDsRGNPtVEVDLHtAKGRFRAA
P13929 T26 Sugiyama ENO3 IFAREILDsRGNPtVEVDLHtAKGRFRAAVPsGAstGIyEA
P14618 S205 Sugiyama PKM OIP3 PK2 PK3 PKM2 VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14618 S37 Sugiyama PKM OIP3 PK2 PK3 PKM2 QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P14618 S55 Sugiyama PKM OIP3 PK2 PK3 PKM2 IDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMNVARLN
P14618 T121 Sugiyama PKM OIP3 PK2 PK3 PKM2 DPILyRPVAVALDTKGPEIRtGLIKGsGtAEVELKKGATLK
P14618 T41 Sugiyama PKM OIP3 PK2 PK3 PKM2 AMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtL
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15924 S2825 Sugiyama DSP AAsVssKGLPsPyNMssAPGsRsGsRsGsRSGsRsGsRsGs
P17066 T40 Sugiyama HSPA6 HSP70B' VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P19525 T529 Sugiyama EIF2AK2 PKR PRKR KKEKTLLQKLLSKKPEDRPNtSEILRTLTVWKKsPEKNERH
P20794 T218 Sugiyama MAK PLFPGTSEVDEIFKICQVLGtPKKSDWPEGYQLASSMNFRF
P21333 S2319 Sugiyama FLNA FLN FLN1 VQEPGDyEVsVKFNEEHIPDsPFVVPVAsPsGDARRLtVss
P21333 S2327 Sugiyama FLNA FLN FLN1 VsVKFNEEHIPDsPFVVPVAsPsGDARRLtVssLQEsGLKV
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23246 T687 Sugiyama SFPQ PSF FGQGGAGPVGGQGPRGMGPGtPAGyGRGREEYEGPNKKPRF
P23284 T81 Sugiyama PPIB CYPB IFGLFGKTVPKTVDNFVALAtGEKGFGYKNSKFHRVIKDFM
P23396 T242 Sugiyama RPS3 OK/SW-cl.26 PIsEQKGGKPEPPAMPQPVPtA___________________
P23588 S597 Sugiyama EIF4B KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P23921 S780 Sugiyama RRM1 RR1 KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________
P23921 T774 Sugiyama RRM1 RR1 KEKLKDKEKVSKEEEEKERNtAAMVCsLENRDECLMCGS__
P25786 S14 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P27540 T227 Sugiyama ARNT BHLHE2 STLYDQVHPDDVDKLREQLStSENALTGRILDLKTGTVKKE
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 S53 Sugiyama CALR CRTC WtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDAR
P27824 S362 Sugiyama CANX WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P28066 S16 Sugiyama PSMA5 _____MFLTRsEyDRGVNtFsPEGRLFQVEyAIEAIKLGST
P28066 S172 Sugiyama PSMA5 QLFHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLK
P29401 T442 Sugiyama TKT GEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAA
P29692 S119 Sugiyama EEF1D EF1D QELQQAIsKLEARLNVLEKssPGHRAtAPQtQHVsPMRQVE
P29692 S65 Sugiyama EEF1D EF1D VILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRIA
P29692 T125 Sugiyama EEF1D EF1D IsKLEARLNVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKP
P29692 T129 Sugiyama EEF1D EF1D EARLNVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPA
P30041 T48 Sugiyama PRDX6 AOP2 KIAA0106 FLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKL
P31943 S104 Sugiyama HNRNPH1 HNRPH HNRPH1 EVFKSNNVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P33176 S175 Sugiyama KIF5B KNS KNS1 VHEDKNRVPYVKGCTERFVCsPDEVMDtIDEGKSNRHVAVT
P33316 S164 Sugiyama DUT YTIPPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDV
P34931 T40 Sugiyama HSPA1L VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P35998 T193 Sugiyama PSMC2 MSS1 TYSDVGGCKEQIEKLREVVEtPLLHPERFVNLGIEPPKGVL
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P37802 Y192 Sugiyama TAGLN2 KIAA0120 CDABP0035 NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P38646 S549 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 IVHVSAKDKGTGREQQIVIQssGGLsKDDIENMVKNAEKYA
P38646 T86 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P38646 T94 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P41091 T109 Sugiyama EIF2S3 EIF2G YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P42166 S159 Sugiyama TMPO LAP2 RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42167 S159 Sugiyama TMPO LAP2 RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S299 Sugiyama MKI67 GLQGETQLLVSRKSRPKsGGsGHAVAEPAsPEQELDQNKGK
P46379 T1080 EPSD|PSP BAG6 BAT3 G3 QLLLSEAVSRAAKAAGARPLtsPEsLsRDLEAPEVQESYRQ
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P48444 S252 Sugiyama ARCN1 COPD GKEVDNFVDKLKsEGEtIMSssMGKRTSEATKMHAPPINME
P48741 T40 Sugiyama HSPA7 HSP70B VGVFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQ
P50502 S181 Sugiyama ST13 AAG2 FAM10A1 HIP SNC6 LQKPNAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
P54652 T225 Sugiyama HSPA2 GGTFDVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLA
P54652 T39 Sugiyama HSPA2 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P55072 S765 Sugiyama VCP HEL-220 HEL-S-70 RsVsDNDIRKyEMFAQtLQQsRGFGsFRFPsGNQGGAGPsQ
P55795 S104 Sugiyama HNRNPH2 FTP3 HNRPH2 EVFKSNsVEMDWVLKHtGPNsPDtANDGFVRLRGLPFGCSK
P57721 T159 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT sQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAVT
P57721 T174 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT EIREstGAQVQVAGDMLPNstERAVTISGTPDAIIQCVKQI
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 T202 Sugiyama ACTB GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61978 S81 Sugiyama HNRNPK HNRPK GGKNIKALRtDyNAsVsVPDssGPERILsISADIETIGEIL
P62241 S4 Sugiyama RPS8 OK/SW-cl.83 _________________MGIsRDNWHKRRKTGGKRKPYHKK
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263 T105 Sugiyama RPS14 PRO2640 CKELGITALHIKLRATGGNRtKtPGPGAQsALRALARSGMK
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62750 T42 Sugiyama RPL23A LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62937 T32 Sugiyama PPIA CYPA VDGEPLGRVsFELFADKVPKtAENFRALSTGEKGFGYKGsC
P62942 S9 Sugiyama FKBP1A FKBP1 FKBP12 ____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 T202 Sugiyama ACTG1 ACTG GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363 T56 Sugiyama TUBA1B MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T82 Sugiyama TUBA1B VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P78347 S210 Sugiyama GTF2I BAP135 WBSCR6 EPKKHVGGRVMVtDADRsILsPGGsCGPIKVKTEPTEDSGI
P78371 S143 Sugiyama CCT2 99D8.1 CCTB PQTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIA
P78371 S150 Sugiyama CCT2 99D8.1 CCTB WREATKAAREALLssAVDHGsDEVKFRQDLMNIAGTTLssK
P78527 T2645 Sugiyama PRKDC HYRC HYRC1 LSARWPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstD
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00613 S363 Sugiyama HSF1 HSTF1 AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q00613 T367 Sugiyama HSF1 HSTF1 ALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNELSDH
Q01518 S295 Sugiyama CAP1 CAP SDDMKTHKNPALKAQSGPVRsGPKPFsAPKPQtsPsPKRAT
Q01518 S301 Sugiyama CAP1 CAP HKNPALKAQSGPVRsGPKPFsAPKPQtsPsPKRATKKEPAV
Q01518 S310 Sugiyama CAP1 CAP SGPVRsGPKPFsAPKPQtsPsPKRATKKEPAVLELEGKKWR
Q01518 T307 Sugiyama CAP1 CAP KAQSGPVRsGPKPFsAPKPQtsPsPKRATKKEPAVLELEGK
Q01581 T506 Sugiyama HMGCS1 HMGCS sNIAtEHIPsPAKKVPRLPAtAAEPEAAVIsNGEH______
Q02543 T102 Sugiyama RPL18A LRYDsRSGtHNMYREyRDLttAGAVtQCyRDMGARHRARAH
Q02543 T24 Sugiyama RPL18A SGTLREYKVVGRCLPTPKCHtPPLYRMRIFAPNHVVAKSRF
Q02543 Y97 Sugiyama RPL18A NFGIWLRYDsRSGtHNMYREyRDLttAGAVtQCyRDMGARH
Q10713 T294 Sugiyama PMPCA INPP5E KIAA0123 MPPA VQPAWGSAEAVDIDRSVAQytGGIAKLERDMSNVSLGPTPI
Q12789 S848 Sugiyama GTF3C1 ERRTIKQESGRAGVRPsssGsAWEACSEAPSKGSQDGVTWE
Q13263 T415 Sugiyama TRIM28 KAP1 RNF96 TIF1B LNAWTKSAEAFGKIVAERPGtNstGPAPMAPPRAPGPLSKQ
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13509 S172 Sugiyama TUBB3 TUBB4 ISKVREEYPDRIMNtFsVVPsPKVSDTVVEPYNATLSIHQL
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13509 T166 Sugiyama TUBB3 TUBB4 GMGTLLISKVREEYPDRIMNtFsVVPsPKVSDTVVEPYNAT
Q13561 S202 Sugiyama DCTN2 DCTN50 EATKNSKGGSGGKttGtPPDssLVtyELHsRPEQDKFSQAA
Q13884 S87 Sugiyama SNTB1 SNT2B1 SFCRGAGAGHPGAGGAQPPDsPAGVRTAFTDLPEQVPESIS
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14103 T193 Sugiyama HNRNPD AUF1 HNRPD KAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVESIEL
Q14181 T130 Sugiyama POLA2 LNSYttPSKGSQKRAIstPEtPLtKRsVstRsPHQLLsPss
Q14181 T133 Sugiyama POLA2 YttPSKGSQKRAIstPEtPLtKRsVstRsPHQLLsPssFsP
Q14204 S3082 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 LHVVFTMNPSSEGLKDRAAtsPALFNRCVLNWFGDWSTEAL
Q14657 T29 Sugiyama LAGE3 DXS9879E ESO3 ITBA2 GGGADGGDGRGGHSCRGGVDtAAAPAGGAPPAHAPGPGRDA
Q14980 S1862 Sugiyama NUMA1 NMP22 NUMA PAsQAsLRAtsstQsLARLGsPDYGNsALLsLPGyRPttRs
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15365 T127 Sugiyama PCBP1 TQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15365 T142 Sugiyama PCBP1 EIREstGAQVQVAGDMLPNstERAITIAGVPQSVTECVKQI
Q15366 T127 Sugiyama PCBP2 sQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15366 T142 Sugiyama PCBP2 EIREstGAQVQVAGDMLPNstERAITIAGIPQSIIECVKQI
Q15642 T302 Sugiyama TRIP10 CIP4 STOT STP VEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTKRWP
Q16204 S244 Sugiyama CCDC6 D10S170 TST1 LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16543 T370 Sugiyama CDC37 CDC37A EAKEGEEAGPGDPLLEAVPKtGDEKDVsV____________
Q16630 T157 Sugiyama CPSF6 CFIM68 SKKLMDLLPKRELHGQNPVVtPCNKQFLsQFEMQSRKTTQS
Q16637 S31 Sugiyama SMN1 SMN SMNT; SMN2 SMNC GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK
Q53EL6 S94 Sugiyama PDCD4 H731 GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2 T56 Sugiyama TUBA3E MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
Q6PKG0 S774 Sugiyama LARP1 KIAA0731 LARP LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q71RC2 S597 Sugiyama LARP4 PP13296 QttIPVsPPsttKPsRAstAsPCNNNINAAtAVALQEPRKL
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 T56 Sugiyama TUBA1A TUBA3 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T82 Sugiyama TUBA1A TUBA3 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7Z2W4 T273 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 FFQGsQEFLASASAsAERsCtPsPDQIsHRAsLEDAPVDDL
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86V81 T148 Sugiyama ALYREF ALY BEF THOC4 EFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQYNG
Q86X29 S510 Sugiyama LSR ILDR3 LISCH RARsVDALDDLtPPstAEsGsRsPtsNGGRSRAYMPPRsRs
Q86X29 T514 Sugiyama LSR ILDR3 LISCH VDALDDLtPPstAEsGsRsPtsNGGRSRAYMPPRsRsRDDL
Q8IWS0 S346 Sugiyama PHF6 CENP-31 KIAA1823 CKNHSGNDERDEEDEERESKsRGKVEIDQQQLtQQQLNGN_
Q8IWX8 S822 Sugiyama CHERP DAN26 SCAF6 SKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRLGEE
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8N122 T908 SIGNOR|EPSD|PSP RPTOR KIAA1303 RAPTOR LtNDVAKQPVSRDLPSGRPGtTGPAGAQYtPHSHQFPRTRK
Q8N1G4 T27 Sugiyama LRRC47 KIAA1185 SESWPELELAERERRRELLLtGPGLEERVRAAGGQLPPRLF
Q8N684 T203 Sugiyama CPSF7 GGIPPRAHsRDssDsADGRAtPsENLVPSSARVDKPPSVLP
Q8NBJ5 S612 Sugiyama COLGALT1 GLT25D1 PSEC0241 QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8NBJ5 S616 Sugiyama COLGALT1 GLT25D1 PSEC0241 EQQALSREAKNsDVLQsPLDsAARDEL______________
Q8NBJ7 T260 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 SPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMGNtPD
Q8NBJ7 T278 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 IDtADGsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPP
Q8NFI4 S181 Sugiyama ST13P5 FAM10A5 LQKPNAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
Q8WUF5 S120 Sugiyama PPP1R13L IASPP NKIP1 PPP1R13BL RAI sEsAPtLHPysPLsPKGRPssPRtPLyLQPDAyGsLDRATS
Q8WUF5 T123 Sugiyama PPP1R13L IASPP NKIP1 PPP1R13BL RAI APtLHPysPLsPKGRPssPRtPLyLQPDAyGsLDRATSPRP
Q8WWM7 S111 Sugiyama ATXN2L A2D A2LG A2LP A2RP PGAAAIGsARGQstGKGPPQsPVFEGVyNNSRMLHFLTAVV
Q969X0 T197 Sugiyama RILPL2 RLP2 REKDAVVTSAKNAGRNKEEKtIIKKLFFFRSGKQT______
Q96B36 S212 Sugiyama AKT1S1 PRAS40 GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96CV9 T525 Sugiyama OPTN FIP2 GLC1E HIP7 HYPL NRP AFEDGGRQsLMEMQsRHGARtsDsDQQAyLVQRGAEDRDWR
Q96EP5 S204 Sugiyama DAZAP1 EVKRAEPRDsKsQAPGQPGAsQWGsRVVPNAANGWAGQPPP
Q96MH2 S76 Sugiyama HEXIM2 L3 EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96QR8 S23 Sugiyama PURB DGDsGsERGGGGGPCGFQPAsRGGGEQEtQELASKRLDIQN
Q96S55 T116 Sugiyama WRNIP1 WHIP GEEGDDGGETESREsyDAPPtPsGARLIPDFPVARsssPGR
Q9BQ04 T152 Sugiyama RBM4B RBM30 DNTEFQGKRMHVQLSTSRLRtAPGMGDQSGCYRCGKEGHWS
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3 T56 Sugiyama TUBA1C TUBA6 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T82 Sugiyama TUBA1C TUBA6 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BQG0 S11 Sugiyama MYBBP1A P160 __________MEsRDPAQPMsPGEAtQsGARPADRYGLLKH
Q9BV73 S2229 Sugiyama CEP250 CEP2 CNAP1 QRLQDELELTRRALEKERLHsPGAtsTAELGSRGEQGVQLG
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BWF3 T152 Sugiyama RBM4 RBM4A DNTEFQGKRMHVQLSTSRLRtAPGMGDQSGCYRCGKEGHWS
Q9C0C2 S1103 Sugiyama TNKS1BP1 KIAA1741 TAB182 KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2 S983 Sugiyama TNKS1BP1 KIAA1741 TAB182 sGGsSRtLDAQDRsFGtRPLssGFsPEEAQQQDEEFEKKIP
Q9NVU7 T552 Sugiyama SDAD1 NUC130 SMPMEERKAKAAAISTSRVLtQEDFQKIRMAQMRKELDAAP
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9NYB0 S203 Sugiyama TERF2IP DRIP5 RAP1 PP8000 RYLKHLRGQEHKyLLGDAPVsPssQKLKRKAEEDPEAADsG
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UI15 Y192 Sugiyama TAGLN3 NP25 NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9UNF1 T81 Sugiyama MAGED2 BCG1 SGVSKAtEVsKtPEAREAPAtQAssttQLtDtQVLAAENKS
Q9UPZ9 Y159 SIGNOR|ELM|EPSD CILK1 ICK KIAA0936 VKIADFGLAREIRSKPPYtDyVsTRWYRAPEVLLRSTNYSS
Q9UQ35 S2132 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9Y262 T248 Sugiyama EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005 LNVLHSLVDKSNINRQLEVytsGGDPEsVAGEyGRHSLYKM
Q9Y266 S139 Sugiyama NUDC IDQKKDAENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKL
Q9Y496 T672 PSP KIF3A KIF3 YLAYTEESLRQSLMKLERPRtSKGKARPKTGRRKRsAKPEt
Q9Y6G9 S207 Sugiyama DYNC1LI1 DNCLI1 EQKLIRDFQEyVEPGEDFPAsPQRRNtAsQEDKDDsVVLPL
Q9Y6G9 T389 Sugiyama DYNC1LI1 DNCLI1 AEDDQVFLMKLQsLLAKQPPtAAGRPVDAsPRVPGGsPRtP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 3.570869e-08 7.447 0 0
Cell Cycle R-HSA-1640170 1.197551e-07 6.922 0 0
Chromatin modifying enzymes R-HSA-3247509 2.696243e-07 6.569 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.948875e-06 5.530 0 0
Cell Cycle, Mitotic R-HSA-69278 5.225756e-06 5.282 0 0
Regulation of TP53 Activity R-HSA-5633007 5.162916e-06 5.287 0 0
NRAGE signals death through JNK R-HSA-193648 6.287392e-06 5.202 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.629746e-05 4.788 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.589398e-05 4.587 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.105383e-05 4.387 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.114440e-05 4.148 0 0
Gene expression (Transcription) R-HSA-74160 1.016186e-04 3.993 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.029226e-04 3.987 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.397856e-04 3.855 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.425989e-04 3.846 0 0
Polo-like kinase mediated events R-HSA-156711 2.148870e-04 3.668 0 0
Signaling by NTRKs R-HSA-166520 2.202809e-04 3.657 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.122389e-04 3.506 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.170842e-04 3.499 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.136888e-04 3.504 0 0
G alpha (12/13) signalling events R-HSA-416482 2.979654e-04 3.526 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.827400e-04 3.549 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.748505e-04 3.561 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.747780e-04 3.426 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.913431e-04 3.407 0 0
Cell Cycle Checkpoints R-HSA-69620 4.685117e-04 3.329 0 0
RNA Polymerase II Transcription R-HSA-73857 5.047782e-04 3.297 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.688564e-04 3.175 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.688564e-04 3.175 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.840786e-04 3.106 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.297607e-04 3.032 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.150660e-03 2.939 0 0
Mitotic Prophase R-HSA-68875 1.160425e-03 2.935 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.199622e-03 2.921 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.236009e-03 2.908 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.270062e-03 2.896 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.370204e-03 2.863 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.342070e-03 2.872 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.327416e-03 2.877 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.510108e-03 2.821 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.541352e-03 2.812 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.541352e-03 2.812 0 0
Nuclear import of Rev protein R-HSA-180746 1.478577e-03 2.830 0 0
Generic Transcription Pathway R-HSA-212436 1.615077e-03 2.792 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.685902e-03 2.773 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.857390e-03 2.731 0 0
NGF-stimulated transcription R-HSA-9031628 2.179505e-03 2.662 0 0
G1/S-Specific Transcription R-HSA-69205 2.313807e-03 2.636 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.470071e-03 2.607 0 0
Cellular Senescence R-HSA-2559583 2.502771e-03 2.602 0 0
HATs acetylate histones R-HSA-3214847 2.549763e-03 2.594 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.601385e-03 2.585 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.859480e-03 2.544 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.857129e-03 2.544 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.994251e-03 2.524 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.083939e-03 2.511 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.244405e-03 2.489 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.380202e-03 2.471 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.593990e-03 2.444 0 0
Apoptotic execution phase R-HSA-75153 3.487152e-03 2.458 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.683018e-03 2.434 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.270133e-03 2.370 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.325533e-03 2.364 0 0
G0 and Early G1 R-HSA-1538133 5.104961e-03 2.292 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.050768e-03 2.297 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.902964e-03 2.310 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.104961e-03 2.292 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.163267e-03 2.287 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.163267e-03 2.287 0 0
M Phase R-HSA-68886 5.678902e-03 2.246 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.275145e-03 2.202 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.201867e-03 2.207 0 0
snRNP Assembly R-HSA-191859 6.251539e-03 2.204 0 0
Metabolism of non-coding RNA R-HSA-194441 6.251539e-03 2.204 0 0
S Phase R-HSA-69242 6.465213e-03 2.189 0 0
Specification of primordial germ cells R-HSA-9827857 6.173663e-03 2.209 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.275145e-03 2.202 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.410459e-03 2.193 0 0
Death Receptor Signaling R-HSA-73887 6.791897e-03 2.168 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 6.861692e-03 2.164 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.205318e-03 2.142 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.373275e-03 2.132 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.373275e-03 2.132 0 0
TGFBR3 expression R-HSA-9839394 7.373275e-03 2.132 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.311011e-03 2.136 0 0
HDMs demethylate histones R-HSA-3214842 7.373275e-03 2.132 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.630651e-03 2.117 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 8.108185e-03 2.091 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.789762e-03 2.108 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.290288e-03 2.081 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.489808e-03 2.071 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.186591e-03 2.037 0 0
Circadian clock R-HSA-9909396 9.101420e-03 2.041 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.156404e-03 2.038 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.250464e-03 2.034 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.250464e-03 2.034 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 9.566287e-03 2.019 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.611471e-03 2.017 0 0
Heme signaling R-HSA-9707616 9.611471e-03 2.017 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 9.887429e-03 2.005 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.077931e-02 1.967 0 0
Specification of the neural plate border R-HSA-9834899 1.047546e-02 1.980 0 0
Signalling to ERKs R-HSA-187687 1.110269e-02 1.955 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.110269e-02 1.955 0 0
Signal Transduction R-HSA-162582 1.122621e-02 1.950 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.269072e-02 1.897 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.269072e-02 1.897 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.269072e-02 1.897 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.269072e-02 1.897 0 0
Cellular response to heat stress R-HSA-3371556 1.234590e-02 1.908 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.239096e-02 1.907 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.323685e-02 1.878 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.332539e-02 1.875 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.369702e-02 1.863 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.369702e-02 1.863 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.440807e-02 1.841 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.428549e-02 1.845 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.490127e-02 1.827 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.490127e-02 1.827 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.565840e-02 1.805 0 0
Signaling by TGFBR3 R-HSA-9839373 1.644034e-02 1.784 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.735493e-02 1.761 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.735493e-02 1.761 0 0
Signaling by Hippo R-HSA-2028269 1.799138e-02 1.745 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.841151e-02 1.735 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.893372e-02 1.723 0 0
Nervous system development R-HSA-9675108 1.939053e-02 1.712 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.002048e-02 1.699 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.952333e-02 1.709 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.004969e-02 1.698 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.004969e-02 1.698 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.058492e-02 1.686 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.069022e-02 1.684 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.121166e-02 1.673 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.140958e-02 1.669 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.181532e-02 1.661 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.209349e-02 1.656 0 0
DCC mediated attractive signaling R-HSA-418885 2.437822e-02 1.613 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.266664e-02 1.645 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.245371e-02 1.649 0 0
G2/M Checkpoints R-HSA-69481 2.278126e-02 1.642 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.485108e-02 1.605 0 0
Type I hemidesmosome assembly R-HSA-446107 2.485108e-02 1.605 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.504251e-02 1.601 0 0
Homology Directed Repair R-HSA-5693538 2.504603e-02 1.601 0 0
Netrin-1 signaling R-HSA-373752 2.508451e-02 1.601 0 0
FOXO-mediated transcription R-HSA-9614085 2.517997e-02 1.599 0 0
Notch-HLH transcription pathway R-HSA-350054 2.530709e-02 1.597 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.530709e-02 1.597 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.813740e-02 1.551 0 0
RUNX2 regulates bone development R-HSA-8941326 2.869011e-02 1.542 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.615176e-02 1.582 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.813740e-02 1.551 0 0
RET signaling R-HSA-8853659 2.869011e-02 1.542 0 0
Glycolysis R-HSA-70171 2.759427e-02 1.559 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.875082e-02 1.541 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.197224e-02 1.495 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.197224e-02 1.495 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.415757e-02 1.467 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.415757e-02 1.467 0 0
ALK mutants bind TKIs R-HSA-9700645 3.415757e-02 1.467 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.317293e-02 1.479 0 0
Cardiogenesis R-HSA-9733709 3.294483e-02 1.482 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.324316e-02 1.478 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.294984e-02 1.482 0 0
Prolonged ERK activation events R-HSA-169893 3.088915e-02 1.510 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.150575e-02 1.502 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.206689e-02 1.494 0 0
Axon guidance R-HSA-422475 3.143605e-02 1.503 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.415757e-02 1.467 0 0
Diseases of DNA repair R-HSA-9675135 3.279550e-02 1.484 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.279550e-02 1.484 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.434824e-02 1.464 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.445837e-02 1.463 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.445837e-02 1.463 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.445837e-02 1.463 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.445837e-02 1.463 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.578945e-02 1.446 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.578945e-02 1.446 0 0
Mitotic Prometaphase R-HSA-68877 3.714349e-02 1.430 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.783357e-02 1.422 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.784403e-02 1.422 0 0
Mitotic Anaphase R-HSA-68882 3.812072e-02 1.419 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.831942e-02 1.417 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.847466e-02 1.415 0 0
MET interacts with TNS proteins R-HSA-8875513 3.878847e-02 1.411 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.348889e-02 1.362 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.348889e-02 1.362 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.035696e-02 1.394 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.878847e-02 1.411 0 0
Signaling by TGFB family members R-HSA-9006936 3.961306e-02 1.402 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.460542e-02 1.351 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.528667e-02 1.344 0 0
Deubiquitination R-HSA-5688426 4.541081e-02 1.343 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.557885e-02 1.341 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.577187e-02 1.339 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.577187e-02 1.339 0 0
HIV Life Cycle R-HSA-162587 4.758632e-02 1.323 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.924293e-02 1.308 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.966868e-02 1.304 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.983249e-02 1.302 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.103129e-02 1.292 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.241326e-02 1.281 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.298046e-02 1.276 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.352329e-02 1.271 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.372058e-02 1.270 0 0
Signaling by ALK in cancer R-HSA-9700206 5.372058e-02 1.270 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 6.030438e-02 1.220 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 6.030438e-02 1.220 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.161862e-02 1.210 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.161862e-02 1.210 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.161862e-02 1.210 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.495534e-02 1.260 0 0
Signaling by RAS mutants R-HSA-6802949 6.161862e-02 1.210 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.524515e-02 1.258 0 0
Cell junction organization R-HSA-446728 5.761342e-02 1.239 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.459528e-02 1.263 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.239549e-02 1.205 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.263777e-02 1.203 0 0
MAP2K and MAPK activation R-HSA-5674135 6.382331e-02 1.195 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.382331e-02 1.195 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.509237e-02 1.186 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.583582e-02 1.182 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.752735e-02 1.171 0 0
Nuclear RNA decay R-HSA-9930044 6.752735e-02 1.171 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.870388e-02 1.163 0 0
G1/S Transition R-HSA-69206 6.973787e-02 1.157 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.291829e-02 1.137 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 7.321920e-02 1.135 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 7.321920e-02 1.135 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 7.321920e-02 1.135 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.364281e-02 1.133 0 0
Activation of RAC1 R-HSA-428540 7.364281e-02 1.133 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 8.623721e-02 1.064 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 8.623721e-02 1.064 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 8.623721e-02 1.064 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 8.623721e-02 1.064 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 8.176446e-02 1.087 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.176446e-02 1.087 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.176446e-02 1.087 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.926955e-02 1.101 0 0
Adipogenesis R-HSA-9843745 7.503673e-02 1.125 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.481949e-02 1.072 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 8.623721e-02 1.064 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.688811e-02 1.114 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 8.017349e-02 1.096 0 0
Neurodegenerative Diseases R-HSA-8863678 8.017349e-02 1.096 0 0
Cell-Cell communication R-HSA-1500931 7.931405e-02 1.101 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.881313e-02 1.103 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.176446e-02 1.087 0 0
RAF activation R-HSA-5673000 8.675374e-02 1.062 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.675374e-02 1.062 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 9.067543e-02 1.043 0 0
Leading Strand Synthesis R-HSA-69109 9.067543e-02 1.043 0 0
Polymerase switching R-HSA-69091 9.067543e-02 1.043 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.067543e-02 1.043 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 9.067543e-02 1.043 0 0
Signaling by LTK R-HSA-9842663 9.067543e-02 1.043 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.228092e-02 1.035 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.228092e-02 1.035 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.376532e-02 1.028 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.384920e-02 1.028 0 0
G2/M Transition R-HSA-69275 9.459914e-02 1.024 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.517238e-02 1.021 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.185061e-01 0.926 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.185061e-01 0.926 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.185061e-01 0.926 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.185061e-01 0.926 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.185061e-01 0.926 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.185061e-01 0.926 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.185061e-01 0.926 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.185061e-01 0.926 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.185061e-01 0.926 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.185061e-01 0.926 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.185061e-01 0.926 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.160346e-01 0.935 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.160346e-01 0.935 0 0
Phosphorylation of Emi1 R-HSA-176417 1.160346e-01 0.935 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.037248e-01 0.984 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.095515e-01 0.960 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.095515e-01 0.960 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.142649e-01 0.942 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.087661e-01 0.964 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.128730e-01 0.947 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.170040e-01 0.932 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.069575e-01 0.971 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.142649e-01 0.942 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.148417e-01 0.940 0 0
Frs2-mediated activation R-HSA-170968 1.095515e-01 0.960 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.100877e-01 0.958 0 0
Regulation of TP53 Expression R-HSA-6804754 1.185061e-01 0.926 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.148417e-01 0.940 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.053782e-01 0.977 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.095918e-01 0.960 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.001789e-01 0.999 0 0
FLT3 signaling in disease R-HSA-9682385 1.089709e-01 0.963 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.037248e-01 0.984 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.117857e-01 0.952 0 0
Inositol phosphate metabolism R-HSA-1483249 1.130288e-01 0.947 0 0
Gastrulation R-HSA-9758941 1.189219e-01 0.925 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.194466e-01 0.923 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.194466e-01 0.923 0 0
Glucose metabolism R-HSA-70326 1.202358e-01 0.920 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.211204e-01 0.917 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.211875e-01 0.917 0 0
Signaling by NOTCH1 R-HSA-1980143 1.228787e-01 0.911 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.233021e-01 0.909 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.242444e-01 0.906 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.242444e-01 0.906 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.263148e-01 0.899 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.267604e-01 0.897 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.277576e-01 0.894 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.277576e-01 0.894 0 0
Signal attenuation R-HSA-74749 1.280633e-01 0.893 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.281525e-01 0.892 0 0
mRNA Splicing R-HSA-72172 1.295166e-01 0.888 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.370776e-01 0.863 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.370776e-01 0.863 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.370776e-01 0.863 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.370776e-01 0.863 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.370776e-01 0.863 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.370776e-01 0.863 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.370776e-01 0.863 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.370776e-01 0.863 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.553718e-01 0.593 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.553718e-01 0.593 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.553718e-01 0.593 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.553718e-01 0.593 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.553718e-01 0.593 0 0
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9036092 2.553718e-01 0.593 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.553718e-01 0.593 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.553718e-01 0.593 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.553718e-01 0.593 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.687945e-01 0.773 0 0
MET activates PTPN11 R-HSA-8865999 1.687945e-01 0.773 0 0
Invadopodia formation R-HSA-8941237 1.687945e-01 0.773 0 0
HCN channels R-HSA-1296061 2.218636e-01 0.654 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.218636e-01 0.654 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.218636e-01 0.654 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.574554e-01 0.447 0 0
Mitochondrial transcription initiation R-HSA-163282 3.574554e-01 0.447 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.574554e-01 0.447 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.574554e-01 0.447 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.574554e-01 0.447 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.574554e-01 0.447 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.574554e-01 0.447 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.574554e-01 0.447 0 0
Defective SLC9A9 causes autism 16 (AUTS16) R-HSA-5619052 3.574554e-01 0.447 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.574554e-01 0.447 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.574554e-01 0.447 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.574554e-01 0.447 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.574554e-01 0.447 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.574554e-01 0.447 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.574554e-01 0.447 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.574554e-01 0.447 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.574554e-01 0.447 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.846794e-01 0.734 0 0
Regulation of PTEN localization R-HSA-8948747 1.846794e-01 0.734 0 0
SOS-mediated signalling R-HSA-112412 1.846794e-01 0.734 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.545234e-01 0.811 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.760071e-01 0.559 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.760071e-01 0.559 0 0
IRS activation R-HSA-74713 2.760071e-01 0.559 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.760071e-01 0.559 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.760071e-01 0.559 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.760071e-01 0.559 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.301652e-01 0.886 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 2.222269e-01 0.653 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.222269e-01 0.653 0 0
MET receptor recycling R-HSA-8875656 2.222269e-01 0.653 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.828192e-01 0.738 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 1.828192e-01 0.738 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.828192e-01 0.738 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.828192e-01 0.738 0 0
Translesion synthesis by REV1 R-HSA-110312 1.523839e-01 0.817 0 0
Translesion Synthesis by POLH R-HSA-110320 1.473329e-01 0.832 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.473329e-01 0.832 0 0
Differentiation of T cells R-HSA-9945266 1.760539e-01 0.754 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.760539e-01 0.754 0 0
Translesion synthesis by POLI R-HSA-5656121 1.760539e-01 0.754 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.760539e-01 0.754 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.126484e-01 0.672 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.126484e-01 0.672 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.126484e-01 0.672 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.610994e-01 0.583 0 0
ARMS-mediated activation R-HSA-170984 2.610994e-01 0.583 0 0
WNT mediated activation of DVL R-HSA-201688 2.610994e-01 0.583 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.299337e-01 0.482 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.299337e-01 0.482 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.299337e-01 0.482 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.299337e-01 0.482 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.299337e-01 0.482 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.299337e-01 0.482 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.299337e-01 0.482 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.299337e-01 0.482 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.299337e-01 0.482 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.299337e-01 0.482 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.455491e-01 0.351 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.455491e-01 0.351 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.455491e-01 0.351 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.455491e-01 0.351 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.455491e-01 0.351 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.455491e-01 0.351 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.455491e-01 0.351 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.455491e-01 0.351 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.455491e-01 0.351 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.010058e-01 0.697 0 0
Translesion synthesis by POLK R-HSA-5655862 2.010058e-01 0.697 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.010058e-01 0.697 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.437030e-01 0.613 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.437030e-01 0.613 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.437030e-01 0.613 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.437030e-01 0.613 0 0
Lagging Strand Synthesis R-HSA-69186 1.892138e-01 0.723 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.007369e-01 0.522 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.007369e-01 0.522 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 2.270595e-01 0.644 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.270595e-01 0.644 0 0
MET promotes cell motility R-HSA-8875878 1.341250e-01 0.872 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.671566e-01 0.777 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.826859e-01 0.417 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.826859e-01 0.417 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.826859e-01 0.417 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.826859e-01 0.417 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.571263e-01 0.804 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.540287e-01 0.595 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.406382e-01 0.468 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.406382e-01 0.468 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.406382e-01 0.468 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.406382e-01 0.468 0 0
Signaling by APC mutants R-HSA-4839744 3.406382e-01 0.468 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.406382e-01 0.468 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.406382e-01 0.468 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.406382e-01 0.468 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.620791e-01 0.790 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.620791e-01 0.790 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.620791e-01 0.790 0 0
Erythropoietin activates RAS R-HSA-9027284 3.082796e-01 0.511 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.591406e-01 0.586 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.394909e-01 0.621 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.394909e-01 0.621 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.926200e-01 0.715 0 0
HIV Transcription Initiation R-HSA-167161 1.926200e-01 0.715 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.926200e-01 0.715 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.479610e-01 0.830 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.389497e-01 0.857 0 0
mRNA 3'-end processing R-HSA-72187 1.818930e-01 0.740 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.614149e-01 0.583 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.838465e-01 0.547 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.838465e-01 0.547 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.838465e-01 0.547 0 0
Negative regulation of MET activity R-HSA-6807004 3.099644e-01 0.509 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.099644e-01 0.509 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.099644e-01 0.509 0 0
Phosphorylation of the APC/C R-HSA-176412 3.412287e-01 0.467 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.803650e-01 0.420 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.803650e-01 0.420 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.803650e-01 0.420 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.335724e-01 0.363 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.335724e-01 0.363 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 4.335724e-01 0.363 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.335724e-01 0.363 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.335724e-01 0.363 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.335724e-01 0.363 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.335724e-01 0.363 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.215694e-01 0.283 0 0
Classical Kir channels R-HSA-1296053 5.215694e-01 0.283 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.215694e-01 0.283 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.215694e-01 0.283 0 0
Defective GSS causes GSS deficiency R-HSA-5579006 5.215694e-01 0.283 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.714667e-01 0.766 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.714667e-01 0.766 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.254689e-01 0.647 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.838743e-01 0.547 0 0
Activation of the pre-replicative complex R-HSA-68962 2.838743e-01 0.547 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.838743e-01 0.547 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.385637e-01 0.470 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.385637e-01 0.470 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.104170e-01 0.677 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.742669e-01 0.427 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.742669e-01 0.427 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.351892e-01 0.869 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.602941e-01 0.585 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.345789e-01 0.476 0 0
MET activates RAS signaling R-HSA-8851805 4.195419e-01 0.377 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.195419e-01 0.377 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.195419e-01 0.377 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.195419e-01 0.377 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.195419e-01 0.377 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.195419e-01 0.377 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.195419e-01 0.377 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.195419e-01 0.377 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.195419e-01 0.377 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.673503e-01 0.435 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.603514e-01 0.443 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.603514e-01 0.443 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.071583e-01 0.390 0 0
Formation of annular gap junctions R-HSA-196025 4.821136e-01 0.317 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.861765e-01 0.730 0 0
PTEN Regulation R-HSA-6807070 1.714715e-01 0.766 0 0
FGFR2 alternative splicing R-HSA-6803529 3.961606e-01 0.402 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.961606e-01 0.402 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.375378e-01 0.862 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.197723e-01 0.658 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.197723e-01 0.658 0 0
HIV elongation arrest and recovery R-HSA-167287 3.862318e-01 0.413 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.862318e-01 0.413 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.578553e-01 0.339 0 0
Separation of Sister Chromatids R-HSA-2467813 1.806184e-01 0.743 0 0
Ephrin signaling R-HSA-3928664 4.396910e-01 0.357 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.396910e-01 0.357 0 0
PKA activation in glucagon signalling R-HSA-164378 4.396910e-01 0.357 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.120231e-01 0.506 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.906956e-01 0.408 0 0
Centrosome maturation R-HSA-380287 3.434301e-01 0.464 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.250216e-01 0.488 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.215270e-01 0.493 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.215270e-01 0.493 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.668272e-01 0.436 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.831668e-01 0.417 0 0
Deadenylation of mRNA R-HSA-429947 4.532544e-01 0.344 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.716784e-01 0.326 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.716784e-01 0.326 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.950489e-01 0.305 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.950489e-01 0.305 0 0
Gap junction degradation R-HSA-190873 5.279961e-01 0.277 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.279961e-01 0.277 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.871705e-01 0.231 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.871705e-01 0.231 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.871705e-01 0.231 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.871705e-01 0.231 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.871705e-01 0.231 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.871705e-01 0.231 0 0
Meiotic synapsis R-HSA-1221632 4.116653e-01 0.385 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.116653e-01 0.385 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.832403e-01 0.417 0 0
Downstream signal transduction R-HSA-186763 4.634016e-01 0.334 0 0
Translation initiation complex formation R-HSA-72649 4.311202e-01 0.365 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.969763e-01 0.401 0 0
HDACs deacetylate histones R-HSA-3214815 4.505323e-01 0.346 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.309195e-01 0.275 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.309195e-01 0.275 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.309195e-01 0.275 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.309195e-01 0.275 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.309195e-01 0.275 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.309195e-01 0.275 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.309195e-01 0.275 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.698569e-01 0.328 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.614555e-01 0.336 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.710365e-01 0.243 0 0
DNA replication initiation R-HSA-68952 5.710365e-01 0.243 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.847143e-01 0.315 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.810874e-01 0.318 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.356777e-01 0.271 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.356777e-01 0.271 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.209194e-01 0.283 0 0
Nucleosome assembly R-HSA-774815 5.209194e-01 0.283 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.080103e-01 0.294 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.653119e-01 0.248 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 5.653119e-01 0.248 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 5.653119e-01 0.248 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.418087e-01 0.266 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.436710e-01 0.265 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.841754e-01 0.233 0 0
Signaling by Erythropoietin R-HSA-9006335 5.873171e-01 0.231 0 0
mRNA Capping R-HSA-72086 5.873171e-01 0.231 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.981135e-01 0.223 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.981135e-01 0.223 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.111516e-01 0.214 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.437797e-01 0.191 0 0
G2 Phase R-HSA-68911 6.437797e-01 0.191 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.437797e-01 0.191 0 0
Defective F9 activation R-HSA-9673221 6.437797e-01 0.191 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.437797e-01 0.191 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.437797e-01 0.191 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.043251e-01 0.219 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 6.074445e-01 0.216 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.074445e-01 0.216 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.151190e-01 0.211 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.151190e-01 0.211 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.186062e-01 0.209 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.186062e-01 0.209 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.186062e-01 0.209 0 0
Cellular response to hypoxia R-HSA-1234174 6.335757e-01 0.198 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.292486e-01 0.201 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 6.292486e-01 0.201 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.447378e-01 0.191 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.483343e-01 0.188 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.483343e-01 0.188 0 0
Transcription of the HIV genome R-HSA-167172 1.607266e-01 0.794 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.988667e-01 0.701 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.770422e-01 0.752 0 0
EGFR downregulation R-HSA-182971 4.634016e-01 0.334 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.545190e-01 0.342 0 0
Signaling by NOTCH3 R-HSA-9012852 2.254302e-01 0.647 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.742669e-01 0.427 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.545190e-01 0.342 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.341250e-01 0.872 0 0
DNA Damage Bypass R-HSA-73893 2.257467e-01 0.646 0 0
Signaling by ERBB2 R-HSA-1227986 2.104170e-01 0.677 0 0
HIV Transcription Elongation R-HSA-167169 3.906956e-01 0.408 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.618530e-01 0.250 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.417849e-01 0.617 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.977848e-01 0.303 0 0
Formation of definitive endoderm R-HSA-9823730 3.099644e-01 0.509 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.628726e-01 0.250 0 0
Signaling by MET R-HSA-6806834 2.335618e-01 0.632 0 0
Chromosome Maintenance R-HSA-73886 4.322098e-01 0.364 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.977848e-01 0.303 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.977848e-01 0.303 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.673503e-01 0.435 0 0
Integrin signaling R-HSA-354192 5.134642e-01 0.289 0 0
Regulation of CDH11 function R-HSA-9762292 5.710365e-01 0.243 0 0
Neurexins and neuroligins R-HSA-6794361 1.818930e-01 0.740 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.614149e-01 0.583 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.524484e-01 0.817 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.346551e-01 0.362 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.569920e-01 0.340 0 0
Cyclin D associated events in G1 R-HSA-69231 2.426569e-01 0.615 0 0
G1 Phase R-HSA-69236 2.426569e-01 0.615 0 0
RNA Polymerase III Transcription R-HSA-74158 6.074445e-01 0.216 0 0
DNA Double Strand Break Response R-HSA-5693606 2.235840e-01 0.651 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.906002e-01 0.720 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.906956e-01 0.408 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.653119e-01 0.248 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.111754e-01 0.214 0 0
DNA strand elongation R-HSA-69190 3.300139e-01 0.481 0 0
Signaling by EGFR R-HSA-177929 2.408117e-01 0.618 0 0
ESR-mediated signaling R-HSA-8939211 5.148261e-01 0.288 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.976428e-01 0.303 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.119240e-01 0.213 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.209194e-01 0.283 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.356534e-01 0.197 0 0
Formation of the posterior neural plate R-HSA-9832991 1.545234e-01 0.811 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.610994e-01 0.583 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.090355e-01 0.510 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.620135e-01 0.790 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.481022e-01 0.349 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.710365e-01 0.243 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.080751e-01 0.294 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.447378e-01 0.191 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.483343e-01 0.188 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.426901e-01 0.615 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.621795e-01 0.790 0 0
Interleukin-15 signaling R-HSA-8983432 2.126484e-01 0.672 0 0
IGF1R signaling cascade R-HSA-2428924 4.935633e-01 0.307 0 0
Signaling by BMP R-HSA-201451 5.356777e-01 0.271 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.742669e-01 0.427 0 0
UCH proteinases R-HSA-5689603 3.593696e-01 0.444 0 0
Signaling by WNT in cancer R-HSA-4791275 3.300139e-01 0.481 0 0
Meiosis R-HSA-1500620 3.019758e-01 0.520 0 0
Hedgehog 'on' state R-HSA-5632684 3.835946e-01 0.416 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.299337e-01 0.482 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.335724e-01 0.363 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.687340e-01 0.433 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.279961e-01 0.277 0 0
Signaling by Activin R-HSA-1502540 5.309195e-01 0.275 0 0
Peptide chain elongation R-HSA-156902 4.614555e-01 0.336 0 0
Formation of apoptosome R-HSA-111458 5.710365e-01 0.243 0 0
PI3K/AKT activation R-HSA-198203 5.710365e-01 0.243 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.653119e-01 0.248 0 0
LGI-ADAM interactions R-HSA-5682910 6.111516e-01 0.214 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.838743e-01 0.547 0 0
Cellular response to starvation R-HSA-9711097 4.439366e-01 0.353 0 0
Signaling by FGFR2 R-HSA-5654738 5.342710e-01 0.272 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.873171e-01 0.231 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.119240e-01 0.213 0 0
Signaling by FGFR4 R-HSA-5654743 4.782227e-01 0.320 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.301652e-01 0.886 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.483343e-01 0.188 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.664511e-01 0.247 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.420546e-01 0.848 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.119240e-01 0.213 0 0
Signaling by Hedgehog R-HSA-5358351 5.156916e-01 0.288 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.603514e-01 0.443 0 0
Cilium Assembly R-HSA-5617833 5.831010e-01 0.234 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.190227e-01 0.660 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.572738e-01 0.447 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.574554e-01 0.447 0 0
Reelin signalling pathway R-HSA-8866376 2.760071e-01 0.559 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.222269e-01 0.653 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.610994e-01 0.583 0 0
Interleukin-6 signaling R-HSA-1059683 2.437030e-01 0.613 0 0
Formation of axial mesoderm R-HSA-9796292 2.437030e-01 0.613 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.195419e-01 0.377 0 0
Adrenoceptors R-HSA-390696 4.821136e-01 0.317 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.961606e-01 0.402 0 0
mTORC1-mediated signalling R-HSA-166208 3.961606e-01 0.402 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.248419e-01 0.372 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.906956e-01 0.408 0 0
Regulation of gap junction activity R-HSA-191650 5.871705e-01 0.231 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.004387e-01 0.397 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.309195e-01 0.275 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.434705e-01 0.843 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.434705e-01 0.843 0 0
Signaling by FGFR3 R-HSA-5654741 5.209194e-01 0.283 0 0
Interleukin-2 signaling R-HSA-9020558 3.406382e-01 0.468 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.116347e-01 0.291 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 4.016108e-01 0.396 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.099618e-01 0.678 0 0
Signaling by ROBO receptors R-HSA-376176 1.547641e-01 0.810 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.807467e-01 0.552 0 0
Myogenesis R-HSA-525793 3.345789e-01 0.476 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.008478e-01 0.397 0 0
Signaling by FGFR1 R-HSA-5654736 6.005184e-01 0.221 0 0
DAP12 signaling R-HSA-2424491 4.378619e-01 0.359 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.417849e-01 0.617 0 0
Signaling by NOTCH R-HSA-157118 4.146235e-01 0.382 0 0
Signalling to RAS R-HSA-167044 3.385637e-01 0.470 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.425818e-01 0.615 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.750091e-01 0.426 0 0
Meiotic recombination R-HSA-912446 6.399750e-01 0.194 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.812712e-01 0.318 0 0
Oncogene Induced Senescence R-HSA-2559585 1.729371e-01 0.762 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.636582e-01 0.334 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.636582e-01 0.334 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.446898e-01 0.191 0 0
Ub-specific processing proteases R-HSA-5689880 4.730763e-01 0.325 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.087932e-01 0.510 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.760071e-01 0.559 0 0
Activation of SMO R-HSA-5635838 1.760539e-01 0.754 0 0
Killing mechanisms R-HSA-9664420 1.760539e-01 0.754 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 1.760539e-01 0.754 0 0
Calcineurin activates NFAT R-HSA-2025928 2.610994e-01 0.583 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.455491e-01 0.351 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.540287e-01 0.595 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.104170e-01 0.677 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.104170e-01 0.677 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.104170e-01 0.677 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.104170e-01 0.677 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.069592e-01 0.684 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.950489e-01 0.305 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 5.279961e-01 0.277 0 0
Signaling by NODAL R-HSA-1181150 5.029588e-01 0.298 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.357581e-01 0.361 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.333948e-01 0.273 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.437797e-01 0.191 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.186062e-01 0.209 0 0
MTOR signalling R-HSA-165159 3.203077e-01 0.494 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.054800e-01 0.392 0 0
Kinesins R-HSA-983189 3.058311e-01 0.515 0 0
RMTs methylate histone arginines R-HSA-3214858 3.608869e-01 0.443 0 0
Activation of BH3-only proteins R-HSA-114452 1.671566e-01 0.777 0 0
Signaling by WNT R-HSA-195721 6.294440e-01 0.201 0 0
DNA Repair R-HSA-73894 1.890830e-01 0.723 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.498808e-01 0.824 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.956338e-01 0.305 0 0
TNF signaling R-HSA-75893 4.698569e-01 0.328 0 0
Developmental Biology R-HSA-1266738 4.380363e-01 0.358 0 0
Reproduction R-HSA-1474165 1.918727e-01 0.717 0 0
Semaphorin interactions R-HSA-373755 3.572738e-01 0.447 0 0
Adherens junctions interactions R-HSA-418990 1.773360e-01 0.751 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 3.299337e-01 0.482 0 0
Inhibition of nitric oxide production R-HSA-9636249 5.215694e-01 0.283 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.961606e-01 0.402 0 0
Lipophagy R-HSA-9613354 5.279961e-01 0.277 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.281553e-01 0.277 0 0
Eukaryotic Translation Termination R-HSA-72764 5.975386e-01 0.224 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.292486e-01 0.201 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 6.483343e-01 0.188 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.104155e-01 0.677 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.104155e-01 0.677 0 0
Cell-cell junction organization R-HSA-421270 2.797843e-01 0.553 0 0
PI Metabolism R-HSA-1483255 2.358845e-01 0.627 0 0
Signaling by VEGF R-HSA-194138 1.419927e-01 0.848 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.936680e-01 0.307 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.977708e-01 0.223 0 0
Cellular responses to stress R-HSA-2262752 2.678094e-01 0.572 0 0
Interleukin-2 family signaling R-HSA-451927 5.398643e-01 0.268 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.826859e-01 0.417 0 0
Neurofascin interactions R-HSA-447043 3.826859e-01 0.417 0 0
Rap1 signalling R-HSA-392517 4.716784e-01 0.326 0 0
Vasopressin-like receptors R-HSA-388479 5.871705e-01 0.231 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.727827e-01 0.429 0 0
MAPK family signaling cascades R-HSA-5683057 3.636354e-01 0.439 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.221270e-01 0.653 0 0
Collagen degradation R-HSA-1442490 5.637530e-01 0.249 0 0
Interleukin-6 family signaling R-HSA-6783589 6.447378e-01 0.191 0 0
Mitochondrial biogenesis R-HSA-1592230 1.681337e-01 0.774 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.071583e-01 0.390 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.071583e-01 0.390 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.279961e-01 0.277 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.292486e-01 0.201 0 0
Cellular responses to stimuli R-HSA-8953897 3.837907e-01 0.416 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.087788e-01 0.293 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.447378e-01 0.191 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.447378e-01 0.191 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.698569e-01 0.328 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.019998e-01 0.396 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.431803e-01 0.353 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.087788e-01 0.293 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.333948e-01 0.273 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.333948e-01 0.273 0 0
Metabolism of RNA R-HSA-8953854 5.564070e-01 0.255 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.574554e-01 0.447 0 0
NrCAM interactions R-HSA-447038 2.760071e-01 0.559 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.610994e-01 0.583 0 0
Sensory perception of salty taste R-HSA-9730628 3.299337e-01 0.482 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.455491e-01 0.351 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.455491e-01 0.351 0 0
TGFBR3 regulates activin signaling R-HSA-9839406 4.455491e-01 0.351 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.007369e-01 0.522 0 0
Regulation of KIT signaling R-HSA-1433559 2.756782e-01 0.560 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.221270e-01 0.653 0 0
Signaling by AXIN mutants R-HSA-4839735 3.803650e-01 0.420 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.803650e-01 0.420 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.335724e-01 0.363 0 0
MET activates STAT3 R-HSA-8875791 5.215694e-01 0.283 0 0
Sodium/Proton exchangers R-HSA-425986 4.821136e-01 0.317 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.396910e-01 0.357 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.794142e-01 0.554 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.871705e-01 0.231 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.871705e-01 0.231 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.309195e-01 0.275 0 0
Metalloprotease DUBs R-HSA-5689901 5.087788e-01 0.293 0 0
Bicarbonate transporters R-HSA-425381 6.111516e-01 0.214 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.437797e-01 0.191 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.437797e-01 0.191 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.437797e-01 0.191 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.977370e-01 0.223 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.292486e-01 0.201 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.292486e-01 0.201 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.356534e-01 0.197 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.601145e-01 0.337 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.807467e-01 0.552 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.104170e-01 0.677 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.405005e-01 0.468 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.673503e-01 0.435 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.398643e-01 0.268 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.950489e-01 0.305 0 0
Signaling by FGFR in disease R-HSA-1226099 3.276384e-01 0.485 0 0
Biotin transport and metabolism R-HSA-196780 5.309195e-01 0.275 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.523839e-01 0.817 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.270595e-01 0.644 0 0
FLT3 Signaling R-HSA-9607240 1.770422e-01 0.752 0 0
HIV Infection R-HSA-162906 2.429362e-01 0.615 0 0
MAP kinase activation R-HSA-450294 5.637530e-01 0.249 0 0
Signaling by PTK6 R-HSA-8848021 2.543137e-01 0.595 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.543137e-01 0.595 0 0
Diseases of programmed cell death R-HSA-9645723 5.674195e-01 0.246 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.336514e-01 0.477 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.871705e-01 0.231 0 0
ERK/MAPK targets R-HSA-198753 5.333948e-01 0.273 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.981135e-01 0.223 0 0
Interleukin-17 signaling R-HSA-448424 5.985940e-01 0.223 0 0
Gene Silencing by RNA R-HSA-211000 1.700795e-01 0.769 0 0
Apoptosis R-HSA-109581 2.156605e-01 0.666 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.357812e-01 0.474 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 2.222269e-01 0.653 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.299337e-01 0.482 0 0
Carnitine shuttle R-HSA-200425 4.248419e-01 0.372 0 0
p38MAPK events R-HSA-171007 5.309195e-01 0.275 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.437797e-01 0.191 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.483343e-01 0.188 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.203077e-01 0.494 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.121049e-01 0.385 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.598724e-01 0.252 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.595436e-01 0.797 0 0
Tie2 Signaling R-HSA-210993 4.396910e-01 0.357 0 0
TBC/RABGAPs R-HSA-8854214 6.247285e-01 0.204 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.333948e-01 0.273 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.209194e-01 0.283 0 0
Programmed Cell Death R-HSA-5357801 5.355228e-01 0.271 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.603514e-01 0.443 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.574554e-01 0.447 0 0
Formation of the anterior neural plate R-HSA-9823739 1.523839e-01 0.817 0 0
DSCAM interactions R-HSA-376172 4.455491e-01 0.351 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.007369e-01 0.522 0 0
Signaling by ALK R-HSA-201556 1.477637e-01 0.830 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.412287e-01 0.467 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.215694e-01 0.283 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.535019e-01 0.452 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.950489e-01 0.305 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.279961e-01 0.277 0 0
Sensory perception of sour taste R-HSA-9729555 5.871705e-01 0.231 0 0
Signaling by SCF-KIT R-HSA-1433557 4.782227e-01 0.320 0 0
Host Interactions of HIV factors R-HSA-162909 4.716372e-01 0.326 0 0
Disorders of Developmental Biology R-HSA-9675151 5.981135e-01 0.223 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.981135e-01 0.223 0 0
Synthesis of PI R-HSA-1483226 6.111516e-01 0.214 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.043251e-01 0.219 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.807467e-01 0.552 0 0
Nephrin family interactions R-HSA-373753 5.029588e-01 0.298 0 0
Sensory processing of sound R-HSA-9659379 5.178996e-01 0.286 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.082796e-01 0.511 0 0
Interleukin-37 signaling R-HSA-9008059 2.838743e-01 0.547 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.950489e-01 0.305 0 0
Collagen chain trimerization R-HSA-8948216 4.714923e-01 0.327 0 0
Regulation of beta-cell development R-HSA-186712 1.965717e-01 0.706 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.412287e-01 0.467 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.335724e-01 0.363 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.335724e-01 0.363 0 0
Dopamine receptors R-HSA-390651 5.871705e-01 0.231 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.871705e-01 0.231 0 0
Anchoring fibril formation R-HSA-2214320 6.483343e-01 0.188 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.603514e-01 0.443 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.345789e-01 0.476 0 0
Influenza Infection R-HSA-168255 2.626431e-01 0.581 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.961606e-01 0.402 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.455491e-01 0.351 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.378258e-01 0.269 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.437797e-01 0.191 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.483343e-01 0.188 0 0
Interleukin-7 signaling R-HSA-1266695 4.812712e-01 0.318 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.009929e-01 0.697 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.396910e-01 0.357 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.292486e-01 0.201 0 0
tRNA processing in the nucleus R-HSA-6784531 1.594876e-01 0.797 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.437797e-01 0.191 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.698569e-01 0.328 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.437797e-01 0.191 0 0
Signaling by Leptin R-HSA-2586552 5.710365e-01 0.243 0 0
Nucleotide Excision Repair R-HSA-5696398 6.514784e-01 0.186 0 0
Extension of Telomeres R-HSA-180786 6.536753e-01 0.185 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.548891e-01 0.184 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.581249e-01 0.182 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.584677e-01 0.181 0 0
PKA activation R-HSA-163615 6.586739e-01 0.181 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.586739e-01 0.181 0 0
Mismatch Repair R-HSA-5358508 6.586739e-01 0.181 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.586739e-01 0.181 0 0
Signaling by ERBB4 R-HSA-1236394 6.625748e-01 0.179 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.626589e-01 0.179 0 0
Hedgehog 'off' state R-HSA-5610787 6.662823e-01 0.176 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.749469e-01 0.171 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.757243e-01 0.170 0 0
Synthesis of DNA R-HSA-69239 6.769516e-01 0.169 0 0
Selenocysteine synthesis R-HSA-2408557 6.792330e-01 0.168 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.803399e-01 0.167 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.822455e-01 0.166 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.826345e-01 0.166 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.826345e-01 0.166 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.826345e-01 0.166 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.826345e-01 0.166 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.826345e-01 0.166 0 0
Repression of WNT target genes R-HSA-4641265 6.826345e-01 0.166 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.826345e-01 0.166 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.826345e-01 0.166 0 0
Pervasive developmental disorders R-HSA-9005895 6.826345e-01 0.166 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.826345e-01 0.166 0 0
Disorders of Nervous System Development R-HSA-9697154 6.826345e-01 0.166 0 0
Regulation of signaling by CBL R-HSA-912631 6.863733e-01 0.163 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.863733e-01 0.163 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.863733e-01 0.163 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.867600e-01 0.163 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.926293e-01 0.159 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.926293e-01 0.159 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.926293e-01 0.159 0 0
PKB-mediated events R-HSA-109703 6.926293e-01 0.159 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.926293e-01 0.159 0 0
PDE3B signalling R-HSA-165160 6.926293e-01 0.159 0 0
Signaling by MAPK mutants R-HSA-9652817 6.926293e-01 0.159 0 0
Ligand-receptor interactions R-HSA-5632681 6.926293e-01 0.159 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.926293e-01 0.159 0 0
Synthesis of PS R-HSA-1483101 6.926293e-01 0.159 0 0
Formation of the Editosome R-HSA-75094 6.926293e-01 0.159 0 0
Relaxin receptors R-HSA-444821 6.926293e-01 0.159 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.926293e-01 0.159 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.926293e-01 0.159 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.926293e-01 0.159 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.927571e-01 0.159 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.933494e-01 0.159 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.933494e-01 0.159 0 0
TRP channels R-HSA-3295583 6.933494e-01 0.159 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.948501e-01 0.158 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.969895e-01 0.157 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.001171e-01 0.155 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.025495e-01 0.153 0 0
Signaling by PDGF R-HSA-186797 7.025495e-01 0.153 0 0
Viral mRNA Translation R-HSA-192823 7.042619e-01 0.152 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.075415e-01 0.150 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.093355e-01 0.149 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.123532e-01 0.147 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.123532e-01 0.147 0 0
Signal transduction by L1 R-HSA-445144 7.123532e-01 0.147 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.141435e-01 0.146 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.141435e-01 0.146 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.141435e-01 0.146 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.141435e-01 0.146 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.141435e-01 0.146 0 0
Processing of SMDT1 R-HSA-8949664 7.141435e-01 0.146 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.141435e-01 0.146 0 0
Maturation of nucleoprotein R-HSA-9683610 7.141435e-01 0.146 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.141435e-01 0.146 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.154983e-01 0.145 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.158013e-01 0.145 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.158013e-01 0.145 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.158013e-01 0.145 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.163265e-01 0.145 0 0
GPER1 signaling R-HSA-9634597 7.173156e-01 0.144 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.187447e-01 0.143 0 0
Signaling by NOTCH2 R-HSA-1980145 7.211946e-01 0.142 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.211946e-01 0.142 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.211946e-01 0.142 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.211946e-01 0.142 0 0
L1CAM interactions R-HSA-373760 7.215369e-01 0.142 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.250768e-01 0.140 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.250768e-01 0.140 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 7.273707e-01 0.138 0 0
Signaling by FGFR R-HSA-190236 7.319405e-01 0.136 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.319405e-01 0.136 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.319405e-01 0.136 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.319405e-01 0.136 0 0
STAT5 Activation R-HSA-9645135 7.347823e-01 0.134 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.347823e-01 0.134 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.347823e-01 0.134 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.347823e-01 0.134 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.347823e-01 0.134 0 0
MET Receptor Activation R-HSA-6806942 7.347823e-01 0.134 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.347823e-01 0.134 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.347823e-01 0.134 0 0
CREB phosphorylation R-HSA-199920 7.347823e-01 0.134 0 0
NADPH regeneration R-HSA-389542 7.347823e-01 0.134 0 0
Nef and signal transduction R-HSA-164944 7.347823e-01 0.134 0 0
HDL clearance R-HSA-8964011 7.347823e-01 0.134 0 0
CREB3 factors activate genes R-HSA-8874211 7.347823e-01 0.134 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.366391e-01 0.133 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.366391e-01 0.133 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.366391e-01 0.133 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.370189e-01 0.133 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.397938e-01 0.131 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.401664e-01 0.131 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.401664e-01 0.131 0 0
Removal of the Flap Intermediate R-HSA-69166 7.429816e-01 0.129 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.429816e-01 0.129 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.429816e-01 0.129 0 0
Malate-aspartate shuttle R-HSA-9856872 7.429816e-01 0.129 0 0
HDL assembly R-HSA-8963896 7.429816e-01 0.129 0 0
Physiological factors R-HSA-5578768 7.429816e-01 0.129 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.467973e-01 0.127 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.506599e-01 0.125 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.509621e-01 0.124 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.531172e-01 0.123 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.536445e-01 0.123 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.536445e-01 0.123 0 0
Ribosome-associated quality control R-HSA-9948299 7.539906e-01 0.123 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.570163e-01 0.121 0 0
DNA methylation R-HSA-5334118 7.570163e-01 0.121 0 0
Late endosomal microautophagy R-HSA-9615710 7.570163e-01 0.121 0 0
DARPP-32 events R-HSA-180024 7.570163e-01 0.121 0 0
GPVI-mediated activation cascade R-HSA-114604 7.581725e-01 0.120 0 0
Calmodulin induced events R-HSA-111933 7.581725e-01 0.120 0 0
CaM pathway R-HSA-111997 7.581725e-01 0.120 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.592714e-01 0.120 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.592714e-01 0.120 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.592714e-01 0.120 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.592714e-01 0.120 0 0
Collagen formation R-HSA-1474290 7.598372e-01 0.119 0 0
Defective pyroptosis R-HSA-9710421 7.610392e-01 0.119 0 0
HSF1-dependent transactivation R-HSA-3371571 7.648217e-01 0.116 0 0
Membrane Trafficking R-HSA-199991 7.660469e-01 0.116 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.691052e-01 0.114 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.692887e-01 0.114 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.692887e-01 0.114 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.692887e-01 0.114 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.692887e-01 0.114 0 0
p75NTR signals via NF-kB R-HSA-193639 7.692887e-01 0.114 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.692887e-01 0.114 0 0
Protein methylation R-HSA-8876725 7.692887e-01 0.114 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.711566e-01 0.113 0 0
Netrin mediated repulsion signals R-HSA-418886 7.711566e-01 0.113 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.711566e-01 0.113 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.711566e-01 0.113 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.711566e-01 0.113 0 0
Recycling of eIF2:GDP R-HSA-72731 7.711566e-01 0.113 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.711566e-01 0.113 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.711566e-01 0.113 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.711566e-01 0.113 0 0
PTK6 Expression R-HSA-8849473 7.711566e-01 0.113 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.711566e-01 0.113 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.711566e-01 0.113 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.711566e-01 0.113 0 0
VLDL clearance R-HSA-8964046 7.711566e-01 0.113 0 0
Glycoprotein hormones R-HSA-209822 7.711566e-01 0.113 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.711566e-01 0.113 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.711566e-01 0.113 0 0
CHL1 interactions R-HSA-447041 7.711566e-01 0.113 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.711566e-01 0.113 0 0
Degradation of DVL R-HSA-4641258 7.752241e-01 0.111 0 0
NCAM1 interactions R-HSA-419037 7.752241e-01 0.111 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.766805e-01 0.110 0 0
DAP12 interactions R-HSA-2172127 7.766805e-01 0.110 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.783345e-01 0.109 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.792956e-01 0.108 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.832309e-01 0.106 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.832309e-01 0.106 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 7.862929e-01 0.104 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.902302e-01 0.102 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.915388e-01 0.102 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.915388e-01 0.102 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.930976e-01 0.101 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.932165e-01 0.101 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.932165e-01 0.101 0 0
Negative regulation of FLT3 R-HSA-9706369 7.932165e-01 0.101 0 0
Budding and maturation of HIV virion R-HSA-162588 7.934477e-01 0.100 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.954902e-01 0.099 0 0
Termination of O-glycan biosynthesis R-HSA-977068 7.997936e-01 0.097 0 0
Growth hormone receptor signaling R-HSA-982772 7.997936e-01 0.097 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.025440e-01 0.096 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.025440e-01 0.096 0 0
Activation of RAS in B cells R-HSA-1169092 8.025440e-01 0.096 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.025440e-01 0.096 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 8.025440e-01 0.096 0 0
FGFR1b ligand binding and activation R-HSA-190370 8.025440e-01 0.096 0 0
TGFBR3 PTM regulation R-HSA-9839383 8.025440e-01 0.096 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.025440e-01 0.096 0 0
Alpha-defensins R-HSA-1462054 8.025440e-01 0.096 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.025440e-01 0.096 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.025440e-01 0.096 0 0
Telomere Maintenance R-HSA-157579 8.025596e-01 0.096 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.056274e-01 0.094 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.062373e-01 0.094 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.100030e-01 0.092 0 0
RNA Polymerase I Transcription R-HSA-73864 8.126126e-01 0.090 0 0
Phase 2 - plateau phase R-HSA-5576893 8.149226e-01 0.089 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.149226e-01 0.089 0 0
Glycine degradation R-HSA-6783984 8.149226e-01 0.089 0 0
Passive transport by Aquaporins R-HSA-432047 8.149226e-01 0.089 0 0
Fibronectin matrix formation R-HSA-1566977 8.149226e-01 0.089 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.149226e-01 0.089 0 0
Synthesis of PG R-HSA-1483148 8.149226e-01 0.089 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.178131e-01 0.087 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.178131e-01 0.087 0 0
EPH-Ephrin signaling R-HSA-2682334 8.185595e-01 0.087 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.187265e-01 0.087 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.189629e-01 0.087 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.189629e-01 0.087 0 0
Recycling pathway of L1 R-HSA-437239 8.189629e-01 0.087 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.208364e-01 0.086 0 0
Attenuation phase R-HSA-3371568 8.208364e-01 0.086 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.208364e-01 0.086 0 0
Aggrephagy R-HSA-9646399 8.208364e-01 0.086 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.208364e-01 0.086 0 0
Diseases of Immune System R-HSA-5260271 8.208364e-01 0.086 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.210889e-01 0.086 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.253518e-01 0.083 0 0
G-protein beta:gamma signalling R-HSA-397795 8.253518e-01 0.083 0 0
DNA Replication R-HSA-69306 8.265566e-01 0.083 0 0
Unwinding of DNA R-HSA-176974 8.296280e-01 0.081 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.296280e-01 0.081 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.296280e-01 0.081 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.296280e-01 0.081 0 0
mRNA Editing R-HSA-75072 8.296280e-01 0.081 0 0
Interleukin-1 processing R-HSA-448706 8.296280e-01 0.081 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.296280e-01 0.081 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.296280e-01 0.081 0 0
Insulin receptor signalling cascade R-HSA-74751 8.307361e-01 0.081 0 0
Co-stimulation by CD28 R-HSA-389356 8.315641e-01 0.080 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.342738e-01 0.079 0 0
Laminin interactions R-HSA-3000157 8.344335e-01 0.079 0 0
Tight junction interactions R-HSA-420029 8.344335e-01 0.079 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.344335e-01 0.079 0 0
Long-term potentiation R-HSA-9620244 8.344335e-01 0.079 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.345664e-01 0.079 0 0
Glycogen storage diseases R-HSA-3229121 8.345664e-01 0.079 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.397072e-01 0.076 0 0
IRS-mediated signalling R-HSA-112399 8.418106e-01 0.075 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.419582e-01 0.075 0 0
Stimuli-sensing channels R-HSA-2672351 8.419582e-01 0.075 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.445191e-01 0.073 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.445191e-01 0.073 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.458939e-01 0.073 0 0
Signaling by Interleukins R-HSA-449147 8.459990e-01 0.073 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.468755e-01 0.072 0 0
Intra-Golgi traffic R-HSA-6811438 8.468755e-01 0.072 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.473473e-01 0.072 0 0
MET activates PTK2 signaling R-HSA-8874081 8.497304e-01 0.071 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.497304e-01 0.071 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.499641e-01 0.071 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.523050e-01 0.069 0 0
Apoptotic factor-mediated response R-HSA-111471 8.523050e-01 0.069 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.523050e-01 0.069 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.523050e-01 0.069 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 8.523050e-01 0.069 0 0
Nephron development R-HSA-9831926 8.523050e-01 0.069 0 0
Dual incision in TC-NER R-HSA-6782135 8.524383e-01 0.069 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.529983e-01 0.069 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.529983e-01 0.069 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.529983e-01 0.069 0 0
Interleukin-27 signaling R-HSA-9020956 8.529983e-01 0.069 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.529983e-01 0.069 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.529983e-01 0.069 0 0
Arachidonate production from DAG R-HSA-426048 8.529983e-01 0.069 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.529983e-01 0.069 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.529983e-01 0.069 0 0
Sperm Motility And Taxes R-HSA-1300642 8.529983e-01 0.069 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 8.529983e-01 0.069 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.529983e-01 0.069 0 0
Peptide hormone biosynthesis R-HSA-209952 8.529983e-01 0.069 0 0
Josephin domain DUBs R-HSA-5689877 8.529983e-01 0.069 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.529983e-01 0.069 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.530584e-01 0.069 0 0
Dual Incision in GG-NER R-HSA-5696400 8.530584e-01 0.069 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.530584e-01 0.069 0 0
Signal amplification R-HSA-392518 8.530584e-01 0.069 0 0
PI3K Cascade R-HSA-109704 8.546494e-01 0.068 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.546494e-01 0.068 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.569683e-01 0.067 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.586734e-01 0.066 0 0
Ca-dependent events R-HSA-111996 8.586734e-01 0.066 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.606524e-01 0.065 0 0
Base Excision Repair R-HSA-73884 8.612782e-01 0.065 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.637807e-01 0.064 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.637807e-01 0.064 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.637807e-01 0.064 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.637807e-01 0.064 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.641786e-01 0.063 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.651803e-01 0.063 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.651803e-01 0.063 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.654528e-01 0.063 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.654528e-01 0.063 0 0
Rab regulation of trafficking R-HSA-9007101 8.666830e-01 0.062 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.682914e-01 0.061 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.682914e-01 0.061 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.682914e-01 0.061 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.682914e-01 0.061 0 0
Diseases of hemostasis R-HSA-9671793 8.682914e-01 0.061 0 0
Maturation of nucleoprotein R-HSA-9694631 8.682914e-01 0.061 0 0
STING mediated induction of host immune responses R-HSA-1834941 8.682914e-01 0.061 0 0
The NLRP3 inflammasome R-HSA-844456 8.682914e-01 0.061 0 0
Interleukin-12 signaling R-HSA-9020591 8.692037e-01 0.061 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.731641e-01 0.059 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.731641e-01 0.059 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.731641e-01 0.059 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.731641e-01 0.059 0 0
Transport of RCbl within the body R-HSA-9758890 8.731641e-01 0.059 0 0
PECAM1 interactions R-HSA-210990 8.731641e-01 0.059 0 0
Suppression of apoptosis R-HSA-9635465 8.731641e-01 0.059 0 0
Prostanoid ligand receptors R-HSA-391908 8.731641e-01 0.059 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.750698e-01 0.058 0 0
Orc1 removal from chromatin R-HSA-68949 8.750698e-01 0.058 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.750698e-01 0.058 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.766613e-01 0.057 0 0
HSF1 activation R-HSA-3371511 8.769387e-01 0.057 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.769387e-01 0.057 0 0
Triglyceride catabolism R-HSA-163560 8.769387e-01 0.057 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.788921e-01 0.056 0 0
Proteasome assembly R-HSA-9907900 8.799910e-01 0.056 0 0
Aquaporin-mediated transport R-HSA-445717 8.808856e-01 0.055 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.826725e-01 0.054 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.826725e-01 0.054 0 0
Glycogen synthesis R-HSA-3322077 8.826725e-01 0.054 0 0
Protein hydroxylation R-HSA-9629569 8.826725e-01 0.054 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.843438e-01 0.053 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.843438e-01 0.053 0 0
PCP/CE pathway R-HSA-4086400 8.852582e-01 0.053 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.868075e-01 0.052 0 0
PPARA activates gene expression R-HSA-1989781 8.874275e-01 0.052 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.875651e-01 0.052 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.875651e-01 0.052 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.875651e-01 0.052 0 0
Metabolism of folate and pterines R-HSA-196757 8.875651e-01 0.052 0 0
Platelet calcium homeostasis R-HSA-418360 8.884486e-01 0.051 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.884486e-01 0.051 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.885329e-01 0.051 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.892896e-01 0.051 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.895795e-01 0.051 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.895795e-01 0.051 0 0
DAG and IP3 signaling R-HSA-1489509 8.895795e-01 0.051 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.905645e-01 0.050 0 0
NF-kB is activated and signals survival R-HSA-209560 8.905645e-01 0.050 0 0
ERKs are inactivated R-HSA-202670 8.905645e-01 0.050 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.905645e-01 0.050 0 0
Sodium/Calcium exchangers R-HSA-425561 8.905645e-01 0.050 0 0
DS-GAG biosynthesis R-HSA-2022923 8.905645e-01 0.050 0 0
Integration of provirus R-HSA-162592 8.905645e-01 0.050 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.912675e-01 0.050 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.922924e-01 0.049 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.955877e-01 0.048 0 0
Basigin interactions R-HSA-210991 8.955877e-01 0.048 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.955877e-01 0.048 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.971891e-01 0.047 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.972266e-01 0.047 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.978082e-01 0.047 0 0
HCMV Late Events R-HSA-9610379 8.978082e-01 0.047 0 0
Post NMDA receptor activation events R-HSA-438064 8.983329e-01 0.047 0 0
Interleukin-12 family signaling R-HSA-447115 8.983329e-01 0.047 0 0
PKR-mediated signaling R-HSA-9833482 8.996518e-01 0.046 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 9.032612e-01 0.044 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.033967e-01 0.044 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.046054e-01 0.044 0 0
Integration of energy metabolism R-HSA-163685 9.047164e-01 0.043 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.055786e-01 0.043 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.055786e-01 0.043 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.055786e-01 0.043 0 0
Interleukin-35 Signalling R-HSA-8984722 9.055786e-01 0.043 0 0
OAS antiviral response R-HSA-8983711 9.055786e-01 0.043 0 0
Stabilization of p53 R-HSA-69541 9.064331e-01 0.043 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.064331e-01 0.043 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.071685e-01 0.042 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.071685e-01 0.042 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.071685e-01 0.042 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.071685e-01 0.042 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.071685e-01 0.042 0 0
Glutathione synthesis and recycling R-HSA-174403 9.071685e-01 0.042 0 0
Assembly Of The HIV Virion R-HSA-175474 9.071685e-01 0.042 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.084656e-01 0.042 0 0
Cargo concentration in the ER R-HSA-5694530 9.090392e-01 0.041 0 0
Generation of second messenger molecules R-HSA-202433 9.147699e-01 0.039 0 0
Signaling by NOTCH4 R-HSA-9013694 9.148545e-01 0.039 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.175379e-01 0.037 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.175379e-01 0.037 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.175379e-01 0.037 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.175379e-01 0.037 0 0
LDL clearance R-HSA-8964038 9.175379e-01 0.037 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.179844e-01 0.037 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.185336e-01 0.037 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 9.185336e-01 0.037 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.185336e-01 0.037 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.185336e-01 0.037 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.185336e-01 0.037 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.185336e-01 0.037 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.185336e-01 0.037 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.185336e-01 0.037 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.185336e-01 0.037 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 9.186407e-01 0.037 0 0
RSV-host interactions R-HSA-9833110 9.196259e-01 0.036 0 0
Co-inhibition by PD-1 R-HSA-389948 9.208180e-01 0.036 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.208574e-01 0.036 0 0
Degradation of CDH1 R-HSA-9766229 9.216076e-01 0.035 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.224368e-01 0.035 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.245342e-01 0.034 0 0
tRNA processing R-HSA-72306 9.249869e-01 0.034 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.261195e-01 0.033 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.268103e-01 0.033 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.268103e-01 0.033 0 0
Syndecan interactions R-HSA-3000170 9.268103e-01 0.033 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.268103e-01 0.033 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.294783e-01 0.032 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.294783e-01 0.032 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.294783e-01 0.032 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.294783e-01 0.032 0 0
cGMP effects R-HSA-418457 9.297118e-01 0.032 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.297118e-01 0.032 0 0
Signal regulatory protein family interactions R-HSA-391160 9.297118e-01 0.032 0 0
P2Y receptors R-HSA-417957 9.297118e-01 0.032 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.297118e-01 0.032 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.302209e-01 0.031 0 0
Striated Muscle Contraction R-HSA-390522 9.335077e-01 0.030 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.335077e-01 0.030 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.335077e-01 0.030 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.335077e-01 0.030 0 0
HCMV Early Events R-HSA-9609690 9.338748e-01 0.030 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.340437e-01 0.030 0 0
Complex III assembly R-HSA-9865881 9.350913e-01 0.029 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.350913e-01 0.029 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.350913e-01 0.029 0 0
SLC transporter disorders R-HSA-5619102 9.387215e-01 0.027 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 9.393567e-01 0.027 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.393567e-01 0.027 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.393567e-01 0.027 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.393567e-01 0.027 0 0
Protein lipoylation R-HSA-9857492 9.393567e-01 0.027 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.393567e-01 0.027 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.393567e-01 0.027 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 9.393567e-01 0.027 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 9.393567e-01 0.027 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 9.393567e-01 0.027 0 0
Other semaphorin interactions R-HSA-416700 9.393567e-01 0.027 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.395458e-01 0.027 0 0
MHC class II antigen presentation R-HSA-2132295 9.398168e-01 0.027 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.399286e-01 0.027 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.399286e-01 0.027 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.399286e-01 0.027 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.401387e-01 0.027 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.402089e-01 0.027 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.402089e-01 0.027 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.402089e-01 0.027 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.418538e-01 0.026 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.424785e-01 0.026 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.424785e-01 0.026 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.424785e-01 0.026 0 0
G protein gated Potassium channels R-HSA-1296059 9.424785e-01 0.026 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.424785e-01 0.026 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.424785e-01 0.026 0 0
Formation of the nephric duct R-HSA-9830364 9.424785e-01 0.026 0 0
Mitochondrial protein import R-HSA-1268020 9.444588e-01 0.025 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.447586e-01 0.025 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.447586e-01 0.025 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.454201e-01 0.024 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.454201e-01 0.024 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.456859e-01 0.024 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.458111e-01 0.024 0 0
PERK regulates gene expression R-HSA-381042 9.462796e-01 0.024 0 0
Selective autophagy R-HSA-9663891 9.470232e-01 0.024 0 0
Interferon Signaling R-HSA-913531 9.471740e-01 0.024 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.472678e-01 0.024 0 0
Amine ligand-binding receptors R-HSA-375280 9.472678e-01 0.024 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.476787e-01 0.023 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.476787e-01 0.023 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.476787e-01 0.023 0 0
Fructose catabolism R-HSA-70350 9.476787e-01 0.023 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.476787e-01 0.023 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.476787e-01 0.023 0 0
Attachment and Entry R-HSA-9678110 9.476787e-01 0.023 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.490586e-01 0.023 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.490611e-01 0.023 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.490611e-01 0.023 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.490611e-01 0.023 0 0
Urea cycle R-HSA-70635 9.490611e-01 0.023 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.500806e-01 0.022 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.514031e-01 0.022 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.517727e-01 0.021 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.517727e-01 0.021 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.517727e-01 0.021 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.522161e-01 0.021 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.522161e-01 0.021 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.522161e-01 0.021 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.522161e-01 0.021 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.528992e-01 0.021 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.548590e-01 0.020 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.548590e-01 0.020 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.548590e-01 0.020 0 0
Coenzyme A biosynthesis R-HSA-196783 9.548590e-01 0.020 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.548590e-01 0.020 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.548590e-01 0.020 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.548590e-01 0.020 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.548590e-01 0.020 0 0
Packaging Of Telomere Ends R-HSA-171306 9.549208e-01 0.020 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.549208e-01 0.020 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.549208e-01 0.020 0 0
Cristae formation R-HSA-8949613 9.549208e-01 0.020 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.549208e-01 0.020 0 0
Voltage gated Potassium channels R-HSA-1296072 9.567375e-01 0.019 0 0
Degradation of AXIN R-HSA-4641257 9.567375e-01 0.019 0 0
Cleavage of the damaged purine R-HSA-110331 9.567375e-01 0.019 0 0
Ion homeostasis R-HSA-5578775 9.583463e-01 0.018 0 0
Cellular response to chemical stress R-HSA-9711123 9.600735e-01 0.018 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.601320e-01 0.018 0 0
Telomere Extension By Telomerase R-HSA-171319 9.601320e-01 0.018 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.601320e-01 0.018 0 0
Inflammasomes R-HSA-622312 9.601320e-01 0.018 0 0
Protein ubiquitination R-HSA-8852135 9.602192e-01 0.018 0 0
IRE1alpha activates chaperones R-HSA-381070 9.608013e-01 0.017 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.608538e-01 0.017 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.610544e-01 0.017 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.610544e-01 0.017 0 0
Catecholamine biosynthesis R-HSA-209905 9.610544e-01 0.017 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.610544e-01 0.017 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.612200e-01 0.017 0 0
Depurination R-HSA-73927 9.612200e-01 0.017 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.612200e-01 0.017 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.612200e-01 0.017 0 0
Regulation of CDH1 Function R-HSA-9764561 9.620609e-01 0.017 0 0
Signaling by Insulin receptor R-HSA-74752 9.637008e-01 0.016 0 0
Intraflagellar transport R-HSA-5620924 9.646076e-01 0.016 0 0
Metal ion SLC transporters R-HSA-425410 9.646076e-01 0.016 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.647623e-01 0.016 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.647623e-01 0.016 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.647623e-01 0.016 0 0
Glucagon-type ligand receptors R-HSA-420092 9.647623e-01 0.016 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.647623e-01 0.016 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.652631e-01 0.015 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.652631e-01 0.015 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.652631e-01 0.015 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.652631e-01 0.015 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.652750e-01 0.015 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.661952e-01 0.015 0 0
GAB1 signalosome R-HSA-180292 9.663997e-01 0.015 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.663997e-01 0.015 0 0
Platelet sensitization by LDL R-HSA-432142 9.663997e-01 0.015 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.663997e-01 0.015 0 0
Triglyceride metabolism R-HSA-8979227 9.685924e-01 0.014 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.688333e-01 0.014 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.688730e-01 0.014 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.688730e-01 0.014 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.689062e-01 0.014 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.710117e-01 0.013 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.710117e-01 0.013 0 0
Other interleukin signaling R-HSA-449836 9.710117e-01 0.013 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.710117e-01 0.013 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.711310e-01 0.013 0 0
Azathioprine ADME R-HSA-9748787 9.711310e-01 0.013 0 0
Glutathione conjugation R-HSA-156590 9.714529e-01 0.013 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.721858e-01 0.012 0 0
Maturation of spike protein R-HSA-9694548 9.721858e-01 0.012 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.725194e-01 0.012 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.725194e-01 0.012 0 0
Trafficking of AMPA receptors R-HSA-399719 9.725194e-01 0.012 0 0
COPII-mediated vesicle transport R-HSA-204005 9.725280e-01 0.012 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.739535e-01 0.011 0 0
PLC beta mediated events R-HSA-112043 9.740700e-01 0.011 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.749908e-01 0.011 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.749908e-01 0.011 0 0
Creatine metabolism R-HSA-71288 9.749908e-01 0.011 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.749908e-01 0.011 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.749908e-01 0.011 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.751355e-01 0.011 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.754988e-01 0.011 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.757515e-01 0.011 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.757515e-01 0.011 0 0
Amyloid fiber formation R-HSA-977225 9.761656e-01 0.010 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.771456e-01 0.010 0 0
GABA B receptor activation R-HSA-977444 9.777863e-01 0.010 0 0
Activation of GABAB receptors R-HSA-991365 9.777863e-01 0.010 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.777863e-01 0.010 0 0
Depyrimidination R-HSA-73928 9.777863e-01 0.010 0 0
G-protein activation R-HSA-202040 9.784240e-01 0.009 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.784240e-01 0.009 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.784240e-01 0.009 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.784240e-01 0.009 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.784240e-01 0.009 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.784240e-01 0.009 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.786143e-01 0.009 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.786143e-01 0.009 0 0
Recycling of bile acids and salts R-HSA-159418 9.786143e-01 0.009 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.786143e-01 0.009 0 0
Interleukin-1 family signaling R-HSA-446652 9.788274e-01 0.009 0 0
Smooth Muscle Contraction R-HSA-445355 9.788388e-01 0.009 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.789638e-01 0.009 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.800050e-01 0.009 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.809442e-01 0.008 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 9.811484e-01 0.008 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.811484e-01 0.008 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.811484e-01 0.008 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.813860e-01 0.008 0 0
Attachment and Entry R-HSA-9694614 9.813860e-01 0.008 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.821528e-01 0.008 0 0
eNOS activation R-HSA-203615 9.833899e-01 0.007 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.833899e-01 0.007 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.833899e-01 0.007 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.833899e-01 0.007 0 0
Mitophagy R-HSA-5205647 9.833899e-01 0.007 0 0
Interleukin-1 signaling R-HSA-9020702 9.836910e-01 0.007 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.839415e-01 0.007 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.839415e-01 0.007 0 0
Fructose metabolism R-HSA-5652084 9.839415e-01 0.007 0 0
Ethanol oxidation R-HSA-71384 9.839415e-01 0.007 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.839415e-01 0.007 0 0
Signaling by KIT in disease R-HSA-9669938 9.839415e-01 0.007 0 0
Cellular hexose transport R-HSA-189200 9.839415e-01 0.007 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.841175e-01 0.007 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.845751e-01 0.007 0 0
TCR signaling R-HSA-202403 9.847861e-01 0.007 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.853714e-01 0.006 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.853714e-01 0.006 0 0
Regulation of Apoptosis R-HSA-169911 9.853714e-01 0.006 0 0
G-protein mediated events R-HSA-112040 9.856264e-01 0.006 0 0
Kidney development R-HSA-9830369 9.856264e-01 0.006 0 0
Toll-like Receptor Cascades R-HSA-168898 9.858202e-01 0.006 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.859315e-01 0.006 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.861464e-01 0.006 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.861464e-01 0.006 0 0
Formation of the ureteric bud R-HSA-9830674 9.861464e-01 0.006 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 9.861464e-01 0.006 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.869992e-01 0.006 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.871221e-01 0.006 0 0
Opioid Signalling R-HSA-111885 9.873047e-01 0.006 0 0
HCMV Infection R-HSA-9609646 9.873150e-01 0.006 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.880486e-01 0.005 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.880486e-01 0.005 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.880486e-01 0.005 0 0
Potassium Channels R-HSA-1296071 9.887576e-01 0.005 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.887576e-01 0.005 0 0
ER-Phagosome pathway R-HSA-1236974 9.893761e-01 0.005 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.893815e-01 0.005 0 0
Fertilization R-HSA-1187000 9.896897e-01 0.005 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.896897e-01 0.005 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.899612e-01 0.004 0 0
Biofilm formation R-HSA-9931953 9.900321e-01 0.004 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.900684e-01 0.004 0 0
Gap junction trafficking and regulation R-HSA-157858 9.900684e-01 0.004 0 0
Developmental Cell Lineages R-HSA-9734767 9.903648e-01 0.004 0 0
ECM proteoglycans R-HSA-3000178 9.904112e-01 0.004 0 0
Regulation of insulin secretion R-HSA-422356 9.905845e-01 0.004 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.911055e-01 0.004 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.911055e-01 0.004 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.911196e-01 0.004 0 0
Cardiac conduction R-HSA-5576891 9.911462e-01 0.004 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.911527e-01 0.004 0 0
Autophagy R-HSA-9612973 9.912346e-01 0.004 0 0
rRNA processing R-HSA-72312 9.916009e-01 0.004 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.917759e-01 0.004 0 0
Leishmania phagocytosis R-HSA-9664417 9.917759e-01 0.004 0 0
Parasite infection R-HSA-9664407 9.917759e-01 0.004 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.917841e-01 0.004 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.918176e-01 0.004 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.919269e-01 0.004 0 0
Ca2+ pathway R-HSA-4086398 9.921928e-01 0.003 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.922964e-01 0.003 0 0
Glycogen metabolism R-HSA-8982491 9.922964e-01 0.003 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.923270e-01 0.003 0 0
Triglyceride biosynthesis R-HSA-75109 9.923270e-01 0.003 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.923869e-01 0.003 0 0
Macroautophagy R-HSA-1632852 9.923869e-01 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.929606e-01 0.003 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.932313e-01 0.003 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.933808e-01 0.003 0 0
Insulin receptor recycling R-HSA-77387 9.933808e-01 0.003 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.933808e-01 0.003 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.933808e-01 0.003 0 0
Pyroptosis R-HSA-5620971 9.933808e-01 0.003 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.936560e-01 0.003 0 0
Phospholipid metabolism R-HSA-1483257 9.936627e-01 0.003 0 0
Heme biosynthesis R-HSA-189451 9.940548e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.940548e-01 0.003 0 0
Translation of Structural Proteins R-HSA-9683701 9.940548e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.942899e-01 0.002 0 0
Protein localization R-HSA-9609507 9.943889e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.948075e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 9.948548e-01 0.002 0 0
Neurotransmitter clearance R-HSA-112311 9.950742e-01 0.002 0 0
G alpha (z) signalling events R-HSA-418597 9.951131e-01 0.002 0 0
Selenoamino acid metabolism R-HSA-2408522 9.951723e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.953695e-01 0.002 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.954179e-01 0.002 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.957509e-01 0.002 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.957509e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.958346e-01 0.002 0 0
Regulated Necrosis R-HSA-5218859 9.958492e-01 0.002 0 0
Platelet homeostasis R-HSA-418346 9.958585e-01 0.002 0 0
Gap junction trafficking R-HSA-190828 9.959792e-01 0.002 0 0
Vesicle-mediated transport R-HSA-5653656 9.961137e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.961550e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.961550e-01 0.002 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.962011e-01 0.002 0 0
Downstream TCR signaling R-HSA-202424 9.963828e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.964728e-01 0.002 0 0
SARS-CoV Infections R-HSA-9679506 9.965339e-01 0.002 0 0
Potential therapeutics for SARS R-HSA-9679191 9.965575e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.968008e-01 0.001 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.968381e-01 0.001 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.969067e-01 0.001 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.969067e-01 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.969067e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.969794e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.970412e-01 0.001 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.972725e-01 0.001 0 0
Heme degradation R-HSA-189483 9.972725e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.972880e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.972880e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.973243e-01 0.001 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.973243e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.973388e-01 0.001 0 0
Ion channel transport R-HSA-983712 9.973575e-01 0.001 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.974026e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.975996e-01 0.001 0 0
RA biosynthesis pathway R-HSA-5365859 9.976473e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.976473e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.979170e-01 0.001 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.979531e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.979705e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.979705e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.981440e-01 0.001 0 0
Muscle contraction R-HSA-397014 9.983107e-01 0.001 0 0
Neddylation R-HSA-8951664 9.983124e-01 0.001 0 0
Ion transport by P-type ATPases R-HSA-936837 9.983581e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.983758e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.984018e-01 0.001 0 0
The phototransduction cascade R-HSA-2514856 9.984018e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.984900e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.984900e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.985512e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.986752e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.986752e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.986936e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.986975e-01 0.001 0 0
Neurotransmitter release cycle R-HSA-112310 9.988674e-01 0.000 0 0
Pentose phosphate pathway R-HSA-71336 9.988765e-01 0.000 0 0
Platelet degranulation R-HSA-114608 9.988883e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.989626e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.989977e-01 0.000 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.990309e-01 0.000 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.990618e-01 0.000 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.991641e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.991792e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.991890e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.993100e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.993100e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.993519e-01 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.993722e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.993781e-01 0.000 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.994349e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.994628e-01 0.000 0 0
Defensins R-HSA-1461973 9.994636e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.994636e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.995202e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.995374e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.995374e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.995374e-01 0.000 0 0
Adaptive Immune System R-HSA-1280218 9.995601e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.995807e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.995821e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.996010e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.996010e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.996558e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.997139e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.997139e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.997152e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.997152e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.997219e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.997440e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.997440e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.997468e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.997792e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998138e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998138e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.998226e-01 0.000 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.998259e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998357e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.998548e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.998667e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.998778e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.999091e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.999091e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999212e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999250e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.999375e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999459e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.999497e-01 0.000 0 0
Neutrophil degranulation R-HSA-6798695 9.999541e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999548e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.999566e-01 0.000 0 0
Neuronal System R-HSA-112316 9.999606e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999793e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999799e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999809e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999831e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999842e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.999846e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999853e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999880e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999896e-01 0.000 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.999896e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999909e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999915e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999925e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999927e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999950e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999951e-01 0.000 0 0
Protein folding R-HSA-391251 9.999955e-01 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 9.999957e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999970e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999974e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999977e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999981e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999990e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999992e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999992e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999993e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999995e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999998e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999999e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999999e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999999e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Translation R-HSA-72766 9.999999e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 1.000000e+00 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Immune System R-HSA-168256 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 3.330669e-16 15.477 0 0
Cell Cycle R-HSA-1640170 1.543210e-14 13.812 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.131628e-14 13.671 0 0
Cell Cycle, Mitotic R-HSA-69278 8.579804e-13 12.067 0 0
Nervous system development R-HSA-9675108 2.420508e-12 11.616 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.238054e-12 11.373 0 0
M Phase R-HSA-68886 1.084277e-11 10.965 0 0
Cellular responses to stress R-HSA-2262752 1.239753e-11 10.907 0 0
Axon guidance R-HSA-422475 1.362577e-11 10.866 0 0
Attenuation phase R-HSA-3371568 3.710798e-11 10.431 0 0
Cellular responses to stimuli R-HSA-8953897 1.264727e-10 9.898 0 0
HSF1-dependent transactivation R-HSA-3371571 2.076691e-10 9.683 0 0
Signal Transduction R-HSA-162582 5.189530e-10 9.285 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.635691e-09 8.439 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.084970e-09 8.389 0 0
Recycling pathway of L1 R-HSA-437239 4.375887e-09 8.359 0 0
HSF1 activation R-HSA-3371511 4.614572e-09 8.336 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.053237e-09 8.296 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.778599e-09 8.057 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.312087e-09 8.031 0 0
Apoptotic execution phase R-HSA-75153 1.341472e-08 7.872 0 0
Mitotic Prometaphase R-HSA-68877 1.688202e-08 7.773 0 0
Gap junction trafficking and regulation R-HSA-157858 3.622436e-08 7.441 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.073268e-08 7.217 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.308408e-08 7.136 0 0
PKR-mediated signaling R-HSA-9833482 7.770609e-08 7.110 0 0
Mitotic Anaphase R-HSA-68882 9.286511e-08 7.032 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.061747e-07 6.974 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.142743e-07 6.942 0 0
Gap junction trafficking R-HSA-190828 1.215166e-07 6.915 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.898250e-07 6.722 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.316609e-07 6.635 0 0
Separation of Sister Chromatids R-HSA-2467813 2.327249e-07 6.633 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.516279e-07 6.599 0 0
Metabolism of RNA R-HSA-8953854 3.012038e-07 6.521 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.179957e-07 6.498 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.418216e-07 6.466 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.387017e-07 6.470 0 0
Aggrephagy R-HSA-9646399 4.083243e-07 6.389 0 0
Mitotic Prophase R-HSA-68875 4.532863e-07 6.344 0 0
Cell Cycle Checkpoints R-HSA-69620 7.271645e-07 6.138 0 0
HCMV Early Events R-HSA-9609690 7.815255e-07 6.107 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.904222e-07 6.004 0 0
Apoptosis R-HSA-109581 9.991939e-07 6.000 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.088760e-06 5.963 0 0
Chromatin organization R-HSA-4839726 1.139457e-06 5.943 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.206790e-06 5.918 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.209924e-06 5.917 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.313743e-06 5.881 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.320299e-06 5.879 0 0
L1CAM interactions R-HSA-373760 1.589701e-06 5.799 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.646963e-06 5.783 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.688096e-06 5.773 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.138008e-06 5.670 0 0
Cellular Senescence R-HSA-2559583 2.474869e-06 5.606 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.600986e-06 5.585 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.639631e-06 5.578 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.975267e-06 5.526 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.976011e-06 5.526 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.710510e-06 5.431 0 0
Chromatin modifying enzymes R-HSA-3247509 3.904183e-06 5.408 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.456704e-06 5.351 0 0
Signaling by ALK in cancer R-HSA-9700206 4.456704e-06 5.351 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.006805e-06 5.300 0 0
Selective autophagy R-HSA-9663891 4.829705e-06 5.316 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.498751e-06 5.260 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.616339e-06 5.251 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.150180e-06 5.211 0 0
Developmental Biology R-HSA-1266738 6.013985e-06 5.221 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.318469e-06 5.199 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.817121e-06 5.166 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.746288e-06 5.011 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.394743e-05 4.856 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.370632e-05 4.863 0 0
Nuclear import of Rev protein R-HSA-180746 1.613514e-05 4.792 0 0
Gap junction assembly R-HSA-190861 1.613514e-05 4.792 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.762427e-05 4.754 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.905777e-05 4.720 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.905777e-05 4.720 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.148704e-05 4.668 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.247974e-05 4.648 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.728822e-05 4.564 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.955152e-05 4.529 0 0
Gene expression (Transcription) R-HSA-74160 3.265165e-05 4.486 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.445607e-05 4.463 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.445607e-05 4.463 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.710309e-05 4.431 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.743995e-05 4.427 0 0
Interferon Signaling R-HSA-913531 4.057338e-05 4.392 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.564128e-05 4.341 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.581235e-05 4.339 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.715262e-05 4.326 0 0
Programmed Cell Death R-HSA-5357801 4.903158e-05 4.310 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.903453e-05 4.309 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.903453e-05 4.309 0 0
Semaphorin interactions R-HSA-373755 5.002454e-05 4.301 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.617530e-05 4.250 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.000979e-05 4.222 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.959258e-05 4.225 0 0
HIV Life Cycle R-HSA-162587 6.484207e-05 4.188 0 0
Metabolism of non-coding RNA R-HSA-194441 6.604715e-05 4.180 0 0
snRNP Assembly R-HSA-191859 6.604715e-05 4.180 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.604715e-05 4.180 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 7.338281e-05 4.134 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.708528e-05 4.113 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.922622e-05 4.101 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.947499e-05 4.100 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.947499e-05 4.100 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.038318e-05 4.095 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.005204e-04 3.998 0 0
Signaling by RAS mutants R-HSA-6802949 1.216700e-04 3.915 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.216700e-04 3.915 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.216700e-04 3.915 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.216700e-04 3.915 0 0
Autophagy R-HSA-9612973 1.207123e-04 3.918 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.175592e-04 3.930 0 0
MAP2K and MAPK activation R-HSA-5674135 1.266619e-04 3.897 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.292162e-04 3.889 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.354173e-04 3.868 0 0
ESR-mediated signaling R-HSA-8939211 1.472212e-04 3.832 0 0
mRNA Splicing R-HSA-72172 1.674599e-04 3.776 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.632398e-04 3.787 0 0
Meiotic synapsis R-HSA-1221632 1.712477e-04 3.766 0 0
Macroautophagy R-HSA-1632852 1.795458e-04 3.746 0 0
Signaling by Hippo R-HSA-2028269 1.833186e-04 3.737 0 0
G2/M Transition R-HSA-69275 1.911234e-04 3.719 0 0
Protein folding R-HSA-391251 1.918885e-04 3.717 0 0
Post NMDA receptor activation events R-HSA-438064 1.920054e-04 3.717 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.017659e-04 3.695 0 0
Activation of BH3-only proteins R-HSA-114452 2.047096e-04 3.689 0 0
Formation of annular gap junctions R-HSA-196025 2.344271e-04 3.630 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.259676e-04 3.646 0 0
HCMV Infection R-HSA-9609646 2.462515e-04 3.609 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.574892e-04 3.589 0 0
G2/M Checkpoints R-HSA-69481 2.656700e-04 3.576 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.737069e-04 3.563 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.821118e-04 3.550 0 0
DNA Double Strand Break Response R-HSA-5693606 2.838585e-04 3.547 0 0
mTORC1-mediated signalling R-HSA-166208 3.069831e-04 3.513 0 0
Gap junction degradation R-HSA-190873 3.930087e-04 3.406 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.953600e-04 3.403 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.599851e-04 3.444 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.662199e-04 3.436 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.784465e-04 3.422 0 0
Gene Silencing by RNA R-HSA-211000 3.597095e-04 3.444 0 0
mRNA 3'-end processing R-HSA-72187 4.031011e-04 3.395 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.101895e-04 3.387 0 0
Cell junction organization R-HSA-446728 4.159257e-04 3.381 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.308155e-04 3.366 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.451495e-04 3.351 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.837146e-04 3.315 0 0
MTOR signalling R-HSA-165159 4.853142e-04 3.314 0 0
Diseases of programmed cell death R-HSA-9645723 5.282610e-04 3.277 0 0
Cilium Assembly R-HSA-5617833 5.287015e-04 3.277 0 0
RNA Polymerase II Transcription R-HSA-73857 5.375113e-04 3.270 0 0
HATs acetylate histones R-HSA-3214847 5.676482e-04 3.246 0 0
Translation initiation complex formation R-HSA-72649 5.778350e-04 3.238 0 0
HDACs deacetylate histones R-HSA-3214815 6.872610e-04 3.163 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.127422e-04 3.147 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.438759e-04 3.191 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.872610e-04 3.163 0 0
Influenza Infection R-HSA-168255 6.822787e-04 3.166 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.794934e-04 3.108 0 0
Cell-Cell communication R-HSA-1500931 7.798129e-04 3.108 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.235010e-04 3.084 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.235010e-04 3.084 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.365812e-04 3.077 0 0
tRNA processing in the nucleus R-HSA-6784531 8.365812e-04 3.077 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.579922e-04 3.067 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.670507e-04 3.062 0 0
Nucleosome assembly R-HSA-774815 8.670507e-04 3.062 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.670507e-04 3.062 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.818870e-04 3.055 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.077391e-04 3.042 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 9.616042e-04 3.017 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.783883e-04 3.009 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.783883e-04 3.009 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.020961e-03 2.991 0 0
Adherens junctions interactions R-HSA-418990 1.028109e-03 2.988 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.115176e-03 2.953 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.044442e-03 2.981 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.157706e-03 2.936 0 0
Deubiquitination R-HSA-5688426 1.105366e-03 2.956 0 0
Interleukin-12 signaling R-HSA-9020591 1.119674e-03 2.951 0 0
HIV Infection R-HSA-162906 1.185427e-03 2.926 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.275490e-03 2.894 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.275490e-03 2.894 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.278246e-03 2.893 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.296215e-03 2.887 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.296215e-03 2.887 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.345020e-03 2.871 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.418367e-03 2.848 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.418367e-03 2.848 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.477142e-03 2.831 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.532942e-03 2.814 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.545507e-03 2.811 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.730470e-03 2.762 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.751765e-03 2.757 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.788191e-03 2.748 0 0
Membrane Trafficking R-HSA-199991 1.842645e-03 2.735 0 0
Deadenylation of mRNA R-HSA-429947 1.902121e-03 2.721 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.038004e-03 2.691 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.038004e-03 2.691 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.045746e-03 2.689 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.080296e-03 2.682 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.080296e-03 2.682 0 0
Centrosome maturation R-HSA-380287 2.257849e-03 2.646 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.212113e-03 2.655 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.456741e-03 2.610 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.345423e-03 2.630 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.522690e-03 2.598 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.599628e-03 2.585 0 0
Signaling by ROBO receptors R-HSA-376176 2.739239e-03 2.562 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.842860e-03 2.546 0 0
Host Interactions of HIV factors R-HSA-162909 2.916963e-03 2.535 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.010876e-03 2.521 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.129260e-03 2.505 0 0
Homology Directed Repair R-HSA-5693538 3.159638e-03 2.500 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.456408e-03 2.461 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.559101e-03 2.449 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.593066e-03 2.445 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.651131e-03 2.438 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.693453e-03 2.433 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.693453e-03 2.433 0 0
Kinesins R-HSA-983189 3.712747e-03 2.430 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.714240e-03 2.430 0 0
Cell-cell junction organization R-HSA-421270 3.826941e-03 2.417 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.860271e-03 2.413 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.949198e-03 2.403 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.949198e-03 2.403 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.101903e-03 2.387 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.388725e-03 2.358 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.388725e-03 2.358 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 4.388725e-03 2.358 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.020847e-03 2.299 0 0
EPH-Ephrin signaling R-HSA-2682334 4.609548e-03 2.336 0 0
Defective pyroptosis R-HSA-9710421 4.433238e-03 2.353 0 0
Generic Transcription Pathway R-HSA-212436 4.993385e-03 2.302 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.123438e-03 2.290 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.125524e-03 2.290 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.626573e-03 2.335 0 0
Viral Infection Pathways R-HSA-9824446 4.865545e-03 2.313 0 0
Interleukin-12 family signaling R-HSA-447115 4.940110e-03 2.306 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.159653e-03 2.287 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.159653e-03 2.287 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.347230e-03 2.272 0 0
DNA methylation R-HSA-5334118 5.539584e-03 2.257 0 0
Glycolysis R-HSA-70171 5.825161e-03 2.235 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.880048e-03 2.231 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.880048e-03 2.231 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.027659e-03 2.220 0 0
Neurodegenerative Diseases R-HSA-8863678 6.117346e-03 2.213 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.117346e-03 2.213 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.117346e-03 2.213 0 0
Signaling by VEGF R-HSA-194138 6.571280e-03 2.182 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.571995e-03 2.182 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.571995e-03 2.182 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.682456e-03 2.175 0 0
Base Excision Repair R-HSA-73884 6.803553e-03 2.167 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.813458e-03 2.167 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.986456e-03 2.156 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.053759e-03 2.152 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.053759e-03 2.152 0 0
G alpha (12/13) signalling events R-HSA-416482 7.056169e-03 2.151 0 0
RNA Polymerase I Transcription R-HSA-73864 7.056169e-03 2.151 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.151537e-03 2.146 0 0
Signaling by Interleukins R-HSA-449147 7.250111e-03 2.140 0 0
Meiosis R-HSA-1500620 7.330861e-03 2.135 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 7.474935e-03 2.126 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.485940e-03 2.126 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.485940e-03 2.126 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.485940e-03 2.126 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.534423e-03 2.123 0 0
Regulation of TP53 Activity R-HSA-5633007 7.811095e-03 2.107 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.000149e-03 2.097 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.540038e-03 2.069 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.547130e-03 2.068 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 8.668370e-03 2.062 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.049848e-02 1.979 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.076599e-03 2.042 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.623512e-03 2.017 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.514911e-03 2.022 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.756382e-03 2.011 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.049848e-02 1.979 0 0
DNA Repair R-HSA-73894 9.733789e-03 2.012 0 0
Myogenesis R-HSA-525793 9.076599e-03 2.042 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.509172e-03 2.022 0 0
Intraflagellar transport R-HSA-5620924 9.254224e-03 2.034 0 0
Signaling by NTRKs R-HSA-166520 9.448572e-03 2.025 0 0
Packaging Of Telomere Ends R-HSA-171306 1.091051e-02 1.962 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.091051e-02 1.962 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.122628e-02 1.950 0 0
Signaling by EGFR R-HSA-177929 1.144401e-02 1.941 0 0
NRAGE signals death through JNK R-HSA-193648 1.144401e-02 1.941 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.163878e-02 1.934 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.169952e-02 1.932 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.172756e-02 1.931 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.172756e-02 1.931 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.213959e-02 1.916 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.261875e-02 1.899 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.300890e-02 1.886 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.316832e-02 1.880 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.367383e-02 1.864 0 0
Ephrin signaling R-HSA-3928664 1.367383e-02 1.864 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.367383e-02 1.864 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.367383e-02 1.864 0 0
Chromosome Maintenance R-HSA-73886 1.410124e-02 1.851 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.419812e-02 1.848 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.436613e-02 1.843 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.436613e-02 1.843 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.456528e-02 1.837 0 0
Regulation of KIT signaling R-HSA-1433559 1.456528e-02 1.837 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.535213e-02 1.814 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.539288e-02 1.813 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.601665e-02 1.795 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.638818e-02 1.785 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.718663e-02 1.765 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.718663e-02 1.765 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.718663e-02 1.765 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.728240e-02 1.762 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.758047e-02 1.755 0 0
MET interacts with TNS proteins R-HSA-8875513 1.758047e-02 1.755 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.785934e-02 1.748 0 0
Signaling by ERBB2 R-HSA-1227986 1.822338e-02 1.739 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.844085e-02 1.734 0 0
DCC mediated attractive signaling R-HSA-418885 1.844085e-02 1.734 0 0
Protein methylation R-HSA-8876725 1.844085e-02 1.734 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.845397e-02 1.734 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.903262e-02 1.721 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.021472e-02 1.694 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.021472e-02 1.694 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.021472e-02 1.694 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.021472e-02 1.694 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.021472e-02 1.694 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.021472e-02 1.694 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.021472e-02 1.694 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.424244e-02 1.615 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.424244e-02 1.615 0 0
SOS-mediated signalling R-HSA-112412 2.424244e-02 1.615 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.424244e-02 1.615 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.296779e-02 1.639 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.296779e-02 1.639 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.061105e-02 1.686 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.061105e-02 1.686 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.061105e-02 1.686 0 0
TGFBR3 expression R-HSA-9839394 2.119135e-02 1.674 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.424244e-02 1.615 0 0
DNA Replication R-HSA-69306 2.241952e-02 1.649 0 0
Cleavage of the damaged purine R-HSA-110331 2.351892e-02 1.629 0 0
RUNX2 regulates bone development R-HSA-8941326 2.051133e-02 1.688 0 0
RET signaling R-HSA-8853659 2.051133e-02 1.688 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.231630e-02 1.651 0 0
Depyrimidination R-HSA-73928 2.231630e-02 1.651 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.462365e-02 1.609 0 0
Integration of provirus R-HSA-162592 2.473198e-02 1.607 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.473198e-02 1.607 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.474105e-02 1.607 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.530326e-02 1.597 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.532515e-02 1.596 0 0
Depurination R-HSA-73927 2.683239e-02 1.571 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.683449e-02 1.571 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.727305e-02 1.564 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.761016e-02 1.559 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.785770e-02 1.555 0 0
Regulation of gap junction activity R-HSA-191650 2.808945e-02 1.551 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.818649e-02 1.550 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.818649e-02 1.550 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.818649e-02 1.550 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.818877e-02 1.550 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.843196e-02 1.546 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.843196e-02 1.546 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.848577e-02 1.545 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.905893e-02 1.537 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.913077e-02 1.536 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.913077e-02 1.536 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.932111e-02 1.533 0 0
Glucose metabolism R-HSA-70326 3.117950e-02 1.506 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.134608e-02 1.504 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.134608e-02 1.504 0 0
Signaling by WNT R-HSA-195721 3.149629e-02 1.502 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.212348e-02 1.493 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.212348e-02 1.493 0 0
MAPK family signaling cascades R-HSA-5683057 3.227602e-02 1.491 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.267746e-02 1.486 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.267746e-02 1.486 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.269031e-02 1.486 0 0
Neurexins and neuroligins R-HSA-6794361 3.293618e-02 1.482 0 0
Signaling by MET R-HSA-6806834 3.316203e-02 1.479 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.316203e-02 1.479 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.347728e-02 1.475 0 0
HIV elongation arrest and recovery R-HSA-167287 3.378158e-02 1.471 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.378158e-02 1.471 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.458819e-02 1.461 0 0
PTEN Regulation R-HSA-6807070 3.654814e-02 1.437 0 0
Hedgehog 'off' state R-HSA-5610787 3.656274e-02 1.437 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.657750e-02 1.437 0 0
RAF activation R-HSA-5673000 3.680153e-02 1.434 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.680153e-02 1.434 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.736181e-02 1.428 0 0
Peptide chain elongation R-HSA-156902 3.842764e-02 1.415 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.874914e-02 1.412 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.897078e-02 1.409 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.897078e-02 1.409 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.897078e-02 1.409 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.897078e-02 1.409 0 0
Frs2-mediated activation R-HSA-170968 3.897078e-02 1.409 0 0
Protein ubiquitination R-HSA-8852135 3.987969e-02 1.399 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.987969e-02 1.399 0 0
Transcription of the HIV genome R-HSA-167172 4.034987e-02 1.394 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.045731e-02 1.393 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.126302e-02 1.384 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.126302e-02 1.384 0 0
Signalling to ERKs R-HSA-187687 4.171791e-02 1.380 0 0
S Phase R-HSA-69242 4.206081e-02 1.376 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 4.239651e-02 1.373 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.239651e-02 1.373 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.239651e-02 1.373 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.409303e-02 1.267 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.409303e-02 1.267 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.409303e-02 1.267 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.657263e-02 1.247 0 0
Activation of the pre-replicative complex R-HSA-68962 4.453817e-02 1.351 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.203054e-02 1.284 0 0
Nucleotide Excision Repair R-HSA-5696398 5.567889e-02 1.254 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.485457e-02 1.261 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.604334e-02 1.337 0 0
Telomere Maintenance R-HSA-157579 5.035562e-02 1.298 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.384200e-02 1.358 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.763221e-02 1.322 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.208721e-02 1.283 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.208721e-02 1.283 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.222077e-02 1.282 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.283398e-02 1.277 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.691693e-02 1.329 0 0
The NLRP3 inflammasome R-HSA-844456 4.830646e-02 1.316 0 0
Regulation of CDH1 Function R-HSA-9764561 5.386797e-02 1.269 0 0
NGF-stimulated transcription R-HSA-9031628 4.432379e-02 1.353 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.666193e-02 1.247 0 0
Reproduction R-HSA-1474165 5.052761e-02 1.296 0 0
MHC class II antigen presentation R-HSA-2132295 4.650492e-02 1.333 0 0
Inositol phosphate metabolism R-HSA-1483249 5.357787e-02 1.271 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.910386e-02 1.309 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.398948e-02 1.268 0 0
Interleukin-37 signaling R-HSA-9008059 4.453817e-02 1.351 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.700669e-02 1.244 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.700669e-02 1.244 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.711771e-02 1.243 0 0
Co-inhibition by PD-1 R-HSA-389948 5.717077e-02 1.243 0 0
G0 and Early G1 R-HSA-1538133 5.733019e-02 1.242 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.734357e-02 1.242 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.734357e-02 1.242 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.865642e-02 1.232 0 0
Death Receptor Signaling R-HSA-73887 5.876703e-02 1.231 0 0
MET promotes cell motility R-HSA-8875878 5.905364e-02 1.229 0 0
Signaling by NOTCH R-HSA-157118 5.920677e-02 1.228 0 0
Meiotic recombination R-HSA-912446 5.957487e-02 1.225 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.969021e-02 1.224 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.150325e-02 1.211 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 6.174173e-02 1.209 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.337517e-02 1.198 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.430875e-02 1.192 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.451532e-02 1.190 0 0
Integrin signaling R-HSA-354192 6.451532e-02 1.190 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.479677e-02 1.188 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.534144e-02 1.185 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.563722e-02 1.183 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.563722e-02 1.183 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.563722e-02 1.183 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.810551e-02 1.167 0 0
Phosphorylation of the APC/C R-HSA-176412 6.810551e-02 1.167 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.810551e-02 1.167 0 0
Prolonged ERK activation events R-HSA-169893 6.810551e-02 1.167 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.011330e-02 1.154 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.030374e-02 1.153 0 0
Regulation of TP53 Expression R-HSA-6804754 7.030374e-02 1.153 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.030374e-02 1.153 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.030374e-02 1.153 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.030374e-02 1.153 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.030374e-02 1.153 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.030374e-02 1.153 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.030374e-02 1.153 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.030374e-02 1.153 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.030374e-02 1.153 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.030374e-02 1.153 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 7.030374e-02 1.153 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.030374e-02 1.153 0 0
Smooth Muscle Contraction R-HSA-445355 7.145817e-02 1.146 0 0
Striated Muscle Contraction R-HSA-390522 7.223472e-02 1.141 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.223472e-02 1.141 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.223472e-02 1.141 0 0
Signaling by TGFBR3 R-HSA-9839373 7.248281e-02 1.140 0 0
SARS-CoV Infections R-HSA-9679506 7.514995e-02 1.124 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.516011e-02 1.124 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.516011e-02 1.124 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 7.516011e-02 1.124 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.516011e-02 1.124 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.550115e-02 1.122 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.550115e-02 1.122 0 0
UCH proteinases R-HSA-5689603 7.696857e-02 1.114 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.792857e-02 1.108 0 0
Inflammasomes R-HSA-622312 7.912816e-02 1.102 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.947789e-02 1.100 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.163560e-02 1.088 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.848508e-02 1.053 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.928367e-02 1.049 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.272502e-02 1.033 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.272502e-02 1.033 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 9.272502e-02 1.033 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.272502e-02 1.033 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.272502e-02 1.033 0 0
FOXO-mediated transcription R-HSA-9614085 9.412615e-02 1.026 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.023685e-01 0.990 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.023685e-01 0.990 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.023685e-01 0.990 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 1.023685e-01 0.990 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.025331e-01 0.989 0 0
MET activates PTPN11 R-HSA-8865999 1.025331e-01 0.989 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.379083e-01 0.860 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.379083e-01 0.860 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.379083e-01 0.860 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 9.551734e-02 1.020 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 9.551734e-02 1.020 0 0
Type I hemidesmosome assembly R-HSA-446107 1.178431e-01 0.929 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.178431e-01 0.929 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 1.178431e-01 0.929 0 0
MET receptor recycling R-HSA-8875656 1.178431e-01 0.929 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 9.730704e-02 1.012 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 9.730704e-02 1.012 0 0
Repression of WNT target genes R-HSA-4641265 9.730704e-02 1.012 0 0
Lipophagy R-HSA-9613354 1.418858e-01 0.848 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.418858e-01 0.848 0 0
WNT mediated activation of DVL R-HSA-201688 1.418858e-01 0.848 0 0
ALK mutants bind TKIs R-HSA-9700645 1.418858e-01 0.848 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.144387e-01 0.941 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.327878e-01 0.877 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.327878e-01 0.877 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.065278e-01 0.973 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.212736e-01 0.916 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.212736e-01 0.916 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.098001e-01 0.959 0 0
Negative regulation of MET activity R-HSA-6807004 1.369131e-01 0.864 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.369131e-01 0.864 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.907410e-02 1.004 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.297145e-01 0.887 0 0
HIV Transcription Elongation R-HSA-167169 1.410875e-01 0.851 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.410875e-01 0.851 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.410875e-01 0.851 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.410875e-01 0.851 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.310676e-01 0.883 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.702646e-02 1.013 0 0
G1 Phase R-HSA-69236 1.153663e-01 0.938 0 0
Cyclin D associated events in G1 R-HSA-69231 1.153663e-01 0.938 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.907410e-02 1.004 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.369131e-01 0.864 0 0
DNA strand elongation R-HSA-69190 1.215120e-01 0.915 0 0
Mismatch Repair R-HSA-5358508 1.065278e-01 0.973 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.252231e-01 0.902 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.379083e-01 0.860 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.069159e-01 0.971 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.379083e-01 0.860 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.363951e-01 0.865 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.178431e-01 0.929 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.425542e-01 0.846 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.297145e-01 0.887 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.025331e-01 0.989 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.298423e-01 0.887 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.327878e-01 0.877 0 0
Vesicle-mediated transport R-HSA-5653656 9.863836e-02 1.006 0 0
Rap1 signalling R-HSA-392517 1.212736e-01 0.916 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.418858e-01 0.848 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.380789e-01 0.860 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.025331e-01 0.989 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.379083e-01 0.860 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.418858e-01 0.848 0 0
Unwinding of DNA R-HSA-176974 1.418858e-01 0.848 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.315017e-01 0.881 0 0
HCMV Late Events R-HSA-9610379 1.011225e-01 0.995 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.327878e-01 0.877 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.418858e-01 0.848 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.418858e-01 0.848 0 0
Netrin-1 signaling R-HSA-373752 1.153663e-01 0.938 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 9.551734e-02 1.020 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 9.551734e-02 1.020 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.164178e-01 0.934 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.375958e-01 0.861 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.004669e-01 0.998 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.269619e-01 0.896 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.212736e-01 0.916 0 0
tRNA processing R-HSA-72306 1.300958e-01 0.886 0 0
Ub-specific processing proteases R-HSA-5689880 1.465792e-01 0.834 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.507254e-01 0.822 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.507254e-01 0.822 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.516078e-01 0.819 0 0
Erythropoietin activates RAS R-HSA-9027284 1.522490e-01 0.817 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.522490e-01 0.817 0 0
p75NTR signals via NF-kB R-HSA-193639 1.522490e-01 0.817 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.522490e-01 0.817 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.529380e-01 0.815 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.533901e-01 0.814 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.533901e-01 0.814 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.533901e-01 0.814 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.535397e-01 0.814 0 0
Sensory processing of sound R-HSA-9659379 1.542750e-01 0.812 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.545272e-01 0.811 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.595553e-01 0.797 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.602339e-01 0.795 0 0
Selenocysteine synthesis R-HSA-2408557 1.618009e-01 0.791 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.652477e-01 0.782 0 0
HIV Transcription Initiation R-HSA-167161 1.652477e-01 0.782 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.652477e-01 0.782 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.652477e-01 0.782 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.673872e-01 0.776 0 0
2-LTR circle formation R-HSA-164843 1.673872e-01 0.776 0 0
Signal attenuation R-HSA-74749 1.673872e-01 0.776 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.673872e-01 0.776 0 0
Josephin domain DUBs R-HSA-5689877 1.673872e-01 0.776 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.706428e-01 0.768 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.706428e-01 0.768 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.710620e-01 0.767 0 0
Oncogene Induced Senescence R-HSA-2559585 1.732992e-01 0.761 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.752094e-01 0.756 0 0
IRS activation R-HSA-74713 1.754483e-01 0.756 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.754483e-01 0.756 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.754483e-01 0.756 0 0
G2 Phase R-HSA-68911 1.754483e-01 0.756 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.754483e-01 0.756 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.754483e-01 0.756 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 1.754483e-01 0.756 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.754483e-01 0.756 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.754483e-01 0.756 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.754483e-01 0.756 0 0
NrCAM interactions R-HSA-447038 1.754483e-01 0.756 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.754483e-01 0.756 0 0
Signaling by Hedgehog R-HSA-5358351 1.758386e-01 0.755 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.779963e-01 0.750 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.793012e-01 0.746 0 0
Eukaryotic Translation Termination R-HSA-72764 1.797366e-01 0.745 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.864184e-01 0.730 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.875418e-01 0.727 0 0
FLT3 signaling in disease R-HSA-9682385 1.875418e-01 0.727 0 0
FGFR2 alternative splicing R-HSA-6803529 1.886050e-01 0.724 0 0
Notch-HLH transcription pathway R-HSA-350054 1.886050e-01 0.724 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.886050e-01 0.724 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.911617e-01 0.719 0 0
Signaling by SCF-KIT R-HSA-1433557 1.911617e-01 0.719 0 0
TBC/RABGAPs R-HSA-8854214 1.911617e-01 0.719 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.929444e-01 0.715 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.931929e-01 0.714 0 0
Disorders of Developmental Biology R-HSA-9675151 1.940505e-01 0.712 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.940505e-01 0.712 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.940505e-01 0.712 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.940505e-01 0.712 0 0
Suppression of apoptosis R-HSA-9635465 1.940907e-01 0.712 0 0
PECAM1 interactions R-HSA-210990 1.940907e-01 0.712 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.942631e-01 0.712 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.942631e-01 0.712 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.942631e-01 0.712 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.942631e-01 0.712 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.942631e-01 0.712 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.942631e-01 0.712 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.942631e-01 0.712 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.973879e-01 0.705 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.973879e-01 0.705 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.973879e-01 0.705 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.767549e-01 0.558 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.767549e-01 0.558 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.767549e-01 0.558 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.767549e-01 0.558 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.767549e-01 0.558 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.767549e-01 0.558 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 2.767549e-01 0.558 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.767549e-01 0.558 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.767549e-01 0.558 0 0
Defective APRT disrupts adenine salvage R-HSA-9734195 2.767549e-01 0.558 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.767549e-01 0.558 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 2.767549e-01 0.558 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.143399e-01 0.669 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.143399e-01 0.669 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.508055e-01 0.455 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.508055e-01 0.455 0 0
Signalling to ERK5 R-HSA-198765 3.508055e-01 0.455 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.508055e-01 0.455 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.508055e-01 0.455 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.508055e-01 0.455 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.508055e-01 0.455 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.508055e-01 0.455 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.508055e-01 0.455 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.508055e-01 0.455 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.539135e-01 0.595 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.217467e-01 0.654 0 0
Anchoring fibril formation R-HSA-2214320 2.217467e-01 0.654 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.217467e-01 0.654 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.217467e-01 0.654 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.936222e-01 0.532 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.936222e-01 0.532 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.936222e-01 0.532 0 0
Disinhibition of SNARE formation R-HSA-114516 2.936222e-01 0.532 0 0
Recycling of eIF2:GDP R-HSA-72731 2.936222e-01 0.532 0 0
MET activates RAS signaling R-HSA-8851805 2.501172e-01 0.602 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.501172e-01 0.602 0 0
Disorders of Nervous System Development R-HSA-9697154 2.501172e-01 0.602 0 0
Pervasive developmental disorders R-HSA-9005895 2.501172e-01 0.602 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.501172e-01 0.602 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.330238e-01 0.478 0 0
Formation of axial mesoderm R-HSA-9796292 2.789787e-01 0.554 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.388928e-01 0.622 0 0
GAB1 signalosome R-HSA-180292 2.388928e-01 0.622 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.388928e-01 0.622 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.081240e-01 0.511 0 0
Removal of the Flap Intermediate R-HSA-69166 3.081240e-01 0.511 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.717654e-01 0.430 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.373640e-01 0.472 0 0
p38MAPK events R-HSA-171007 3.373640e-01 0.472 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.486134e-01 0.604 0 0
Lagging Strand Synthesis R-HSA-69186 3.097637e-01 0.509 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.186466e-01 0.660 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.056655e-01 0.687 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.665274e-01 0.436 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.329145e-01 0.633 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.338937e-01 0.476 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.186050e-01 0.660 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.072638e-01 0.512 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.072638e-01 0.512 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.161743e-01 0.665 0 0
Signaling by Erythropoietin R-HSA-9006335 3.281724e-01 0.484 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.281724e-01 0.484 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.954615e-01 0.403 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.954615e-01 0.403 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.591670e-01 0.586 0 0
G1/S-Specific Transcription R-HSA-69205 3.217056e-01 0.493 0 0
EGFR downregulation R-HSA-182971 3.703249e-01 0.431 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.241102e-01 0.489 0 0
Viral mRNA Translation R-HSA-192823 2.562556e-01 0.591 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.399672e-01 0.469 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.399672e-01 0.469 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.666218e-01 0.436 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.839760e-01 0.416 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.719791e-01 0.429 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.880765e-01 0.411 0 0
Neutrophil degranulation R-HSA-6798695 3.873953e-01 0.412 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.661264e-01 0.575 0 0
G-protein beta:gamma signalling R-HSA-397795 2.486134e-01 0.604 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.661264e-01 0.575 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.081240e-01 0.511 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.263771e-01 0.645 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.425279e-01 0.465 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.425279e-01 0.465 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.877102e-01 0.541 0 0
G1/S Transition R-HSA-69206 2.605881e-01 0.584 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.581012e-01 0.446 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.954615e-01 0.403 0 0
Developmental Cell Lineages R-HSA-9734767 3.522404e-01 0.453 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.936222e-01 0.532 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.717654e-01 0.430 0 0
Nuclear RNA decay R-HSA-9930044 2.486134e-01 0.604 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.518247e-01 0.599 0 0
Cellular response to starvation R-HSA-9711097 2.061944e-01 0.686 0 0
Killing mechanisms R-HSA-9664420 3.665274e-01 0.436 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.665274e-01 0.436 0 0
Synthesis of DNA R-HSA-69239 2.226819e-01 0.652 0 0
NF-kB is activated and signals survival R-HSA-209560 2.217467e-01 0.654 0 0
Activation of RAC1 R-HSA-428540 2.217467e-01 0.654 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.501172e-01 0.602 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.373640e-01 0.472 0 0
MAP kinase activation R-HSA-450294 2.176884e-01 0.662 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.822902e-01 0.418 0 0
Trafficking of AMPA receptors R-HSA-399719 3.703249e-01 0.431 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.421067e-01 0.466 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.661264e-01 0.575 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.731344e-01 0.428 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.666877e-01 0.436 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.282097e-01 0.484 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.666877e-01 0.436 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 2.501172e-01 0.602 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.417044e-01 0.617 0 0
Signalling to RAS R-HSA-167044 3.097637e-01 0.509 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.474965e-01 0.606 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.070165e-01 0.684 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.321114e-01 0.634 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.710989e-01 0.431 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.070165e-01 0.684 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.070165e-01 0.684 0 0
Interleukin-17 signaling R-HSA-448424 3.369205e-01 0.472 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.015994e-01 0.696 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 2.143399e-01 0.669 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.161521e-01 0.665 0 0
Adrenoceptors R-HSA-390696 3.330238e-01 0.478 0 0
Nucleotide salvage defects R-HSA-9734207 3.330238e-01 0.478 0 0
Calcineurin activates NFAT R-HSA-2025928 3.717654e-01 0.430 0 0
Adipogenesis R-HSA-9843745 3.285395e-01 0.483 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.281724e-01 0.484 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.486134e-01 0.604 0 0
Signaling by FGFR2 R-HSA-5654738 2.479264e-01 0.606 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.501172e-01 0.602 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.789787e-01 0.554 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.665274e-01 0.436 0 0
Formation of definitive endoderm R-HSA-9823730 2.858139e-01 0.544 0 0
Signaling by FGFR4 R-HSA-5654743 3.150366e-01 0.502 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.143399e-01 0.669 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.143399e-01 0.669 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.858139e-01 0.544 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.641477e-01 0.578 0 0
Rab regulation of trafficking R-HSA-9007101 2.562662e-01 0.591 0 0
Signaling by NOTCH3 R-HSA-9012852 3.719791e-01 0.429 0 0
Signaling by FGFR3 R-HSA-5654741 3.493230e-01 0.457 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.539135e-01 0.595 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.022430e-01 0.694 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.954615e-01 0.403 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.281724e-01 0.484 0 0
Signaling by FGFR1 R-HSA-5654736 3.880765e-01 0.411 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.918581e-01 0.535 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.621525e-01 0.581 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.665987e-01 0.574 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.373640e-01 0.472 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.090046e-01 0.680 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.767549e-01 0.558 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.767549e-01 0.558 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.767549e-01 0.558 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.767549e-01 0.558 0 0
Proton/oligopeptide cotransporters R-HSA-427975 2.143399e-01 0.669 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.508055e-01 0.455 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.508055e-01 0.455 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.936222e-01 0.532 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.330238e-01 0.478 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.388928e-01 0.622 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.460415e-01 0.609 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.072638e-01 0.512 0 0
Interleukin-1 family signaling R-HSA-446652 2.977212e-01 0.526 0 0
Signaling by FGFR in disease R-HSA-1226099 3.934942e-01 0.405 0 0
Platelet degranulation R-HSA-114608 2.794694e-01 0.554 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.501172e-01 0.602 0 0
Signaling by PTK6 R-HSA-8848021 2.427176e-01 0.615 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.427176e-01 0.615 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.072071e-01 0.684 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 3.683222e-01 0.434 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.717654e-01 0.430 0 0
Signaling by TGFB family members R-HSA-9006936 2.210976e-01 0.655 0 0
NCAM signaling for neurite out-growth R-HSA-375165 2.300733e-01 0.638 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 2.936222e-01 0.532 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.789787e-01 0.554 0 0
Amyloid fiber formation R-HSA-977225 2.595671e-01 0.586 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.556034e-01 0.592 0 0
Signaling by KIT in disease R-HSA-9669938 3.581012e-01 0.446 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.767549e-01 0.558 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.539135e-01 0.595 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 2.936222e-01 0.532 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.717654e-01 0.430 0 0
ARMS-mediated activation R-HSA-170984 3.717654e-01 0.430 0 0
Signaling by ALK R-HSA-201556 2.328863e-01 0.633 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.338937e-01 0.476 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.150366e-01 0.502 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.936222e-01 0.532 0 0
Syndecan interactions R-HSA-3000170 3.822902e-01 0.418 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.493230e-01 0.457 0 0
TNF signaling R-HSA-75893 3.880765e-01 0.411 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.161521e-01 0.665 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.717654e-01 0.430 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.665274e-01 0.436 0 0
Fibronectin matrix formation R-HSA-1566977 3.954615e-01 0.403 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.783542e-01 0.422 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.666218e-01 0.436 0 0
RMTs methylate histone arginines R-HSA-3214858 3.321157e-01 0.479 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.306687e-01 0.481 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.143399e-01 0.669 0 0
Interleukin-1 processing R-HSA-448706 3.717654e-01 0.430 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.717654e-01 0.430 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.388928e-01 0.622 0 0
IRE1alpha activates chaperones R-HSA-381070 2.095914e-01 0.679 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.717654e-01 0.430 0 0
Diseases of Immune System R-HSA-5260271 3.973281e-01 0.401 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.973281e-01 0.401 0 0
Generation of second messenger molecules R-HSA-202433 3.973281e-01 0.401 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.973281e-01 0.401 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.973281e-01 0.401 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.973281e-01 0.401 0 0
Signaling by FGFR R-HSA-190236 3.977928e-01 0.400 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.997420e-01 0.398 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.997420e-01 0.398 0 0
Co-stimulation by CD28 R-HSA-389356 4.013505e-01 0.396 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.063714e-01 0.391 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.063714e-01 0.391 0 0
Binding and entry of HIV virion R-HSA-173107 4.095692e-01 0.388 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.095692e-01 0.388 0 0
DNA replication initiation R-HSA-68952 4.095692e-01 0.388 0 0
Formation of apoptosome R-HSA-111458 4.095692e-01 0.388 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.095692e-01 0.388 0 0
PI3K/AKT activation R-HSA-198203 4.095692e-01 0.388 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.095692e-01 0.388 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.095692e-01 0.388 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.095692e-01 0.388 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.095692e-01 0.388 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.095692e-01 0.388 0 0
Signaling by Leptin R-HSA-2586552 4.095692e-01 0.388 0 0
Ribosome-associated quality control R-HSA-9948299 4.107227e-01 0.386 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.124968e-01 0.385 0 0
Cardiogenesis R-HSA-9733709 4.124968e-01 0.385 0 0
Infectious disease R-HSA-5663205 4.155183e-01 0.381 0 0
FLT3 Signaling R-HSA-9607240 4.162728e-01 0.381 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.172782e-01 0.380 0 0
Defective HPRT1 disrupts guanine and hypoxanthine salvage R-HSA-9734281 4.172782e-01 0.380 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.172782e-01 0.380 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.172782e-01 0.380 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.172782e-01 0.380 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.172782e-01 0.380 0 0
MET activates STAT3 R-HSA-8875791 4.172782e-01 0.380 0 0
Histamine receptors R-HSA-390650 4.172782e-01 0.380 0 0
The NLRP1 inflammasome R-HSA-844455 4.172782e-01 0.380 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.187114e-01 0.378 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.240314e-01 0.373 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.240314e-01 0.373 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.240314e-01 0.373 0 0
Specification of primordial germ cells R-HSA-9827857 4.240314e-01 0.373 0 0
Immune System R-HSA-168256 4.250880e-01 0.372 0 0
Long-term potentiation R-HSA-9620244 4.302625e-01 0.366 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.302625e-01 0.366 0 0
HDMs demethylate histones R-HSA-3214842 4.302625e-01 0.366 0 0
Circadian clock R-HSA-9909396 4.323285e-01 0.364 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.334421e-01 0.363 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.334421e-01 0.363 0 0
Interleukin-1 signaling R-HSA-9020702 4.349516e-01 0.362 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.350735e-01 0.361 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.359343e-01 0.361 0 0
Mitochondrial biogenesis R-HSA-1592230 4.452019e-01 0.351 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.462211e-01 0.350 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.462211e-01 0.350 0 0
Formation of the posterior neural plate R-HSA-9832991 4.462211e-01 0.350 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.462211e-01 0.350 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 4.462211e-01 0.350 0 0
Bicarbonate transporters R-HSA-425381 4.462211e-01 0.350 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.462211e-01 0.350 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.521195e-01 0.345 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.521195e-01 0.345 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.521195e-01 0.345 0 0
Polo-like kinase mediated events R-HSA-156711 4.521195e-01 0.345 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.521195e-01 0.345 0 0
MET activates PTK2 signaling R-HSA-8874081 4.538885e-01 0.343 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.538885e-01 0.343 0 0
Metalloprotease DUBs R-HSA-5689901 4.538885e-01 0.343 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.539087e-01 0.343 0 0
Dual Incision in GG-NER R-HSA-5696400 4.542217e-01 0.343 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.542217e-01 0.343 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.542217e-01 0.343 0 0
Mitophagy R-HSA-5205647 4.542217e-01 0.343 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.703926e-01 0.328 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.725226e-01 0.326 0 0
PERK regulates gene expression R-HSA-381042 4.747866e-01 0.324 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.769481e-01 0.322 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.769481e-01 0.322 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.769481e-01 0.322 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.769481e-01 0.322 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.769481e-01 0.322 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.769481e-01 0.322 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.769481e-01 0.322 0 0
GABA synthesis R-HSA-888568 4.769481e-01 0.322 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.769481e-01 0.322 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.771817e-01 0.321 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.771817e-01 0.321 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.796247e-01 0.319 0 0
Regulation of signaling by CBL R-HSA-912631 4.796247e-01 0.319 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.796247e-01 0.319 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.796247e-01 0.319 0 0
Maturation of nucleoprotein R-HSA-9694631 4.796247e-01 0.319 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.813868e-01 0.318 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.813868e-01 0.318 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.815610e-01 0.317 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.815610e-01 0.317 0 0
Signaling by AXIN mutants R-HSA-4839735 4.815610e-01 0.317 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.815610e-01 0.317 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.815610e-01 0.317 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.815610e-01 0.317 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.815610e-01 0.317 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.815610e-01 0.317 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.815610e-01 0.317 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.815610e-01 0.317 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.842314e-01 0.315 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.842314e-01 0.315 0 0
Heme signaling R-HSA-9707616 4.842314e-01 0.315 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.873864e-01 0.312 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.950918e-01 0.305 0 0
RNA Polymerase III Transcription R-HSA-74158 4.950918e-01 0.305 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.950918e-01 0.305 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.993874e-01 0.302 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.999535e-01 0.301 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.999535e-01 0.301 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.000813e-01 0.301 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.000813e-01 0.301 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.042179e-01 0.297 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.064615e-01 0.295 0 0
Signal transduction by L1 R-HSA-445144 5.064615e-01 0.295 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.154731e-01 0.288 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.154731e-01 0.288 0 0
Polymerase switching R-HSA-69091 5.154731e-01 0.288 0 0
Leading Strand Synthesis R-HSA-69109 5.154731e-01 0.288 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.154731e-01 0.288 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.154731e-01 0.288 0 0
Signaling by LTK R-HSA-9842663 5.154731e-01 0.288 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.154731e-01 0.288 0 0
OAS antiviral response R-HSA-8983711 5.154731e-01 0.288 0 0
G alpha (z) signalling events R-HSA-418597 5.208620e-01 0.283 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.225337e-01 0.282 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.225337e-01 0.282 0 0
Platelet calcium homeostasis R-HSA-418360 5.225337e-01 0.282 0 0
Transmission across Chemical Synapses R-HSA-112315 5.253040e-01 0.280 0 0
Signaling by NOTCH4 R-HSA-9013694 5.254362e-01 0.279 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.271343e-01 0.278 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.271343e-01 0.278 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.305110e-01 0.275 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.305110e-01 0.275 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.305110e-01 0.275 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.305110e-01 0.275 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.305110e-01 0.275 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.305110e-01 0.275 0 0
Reelin signalling pathway R-HSA-8866376 5.305110e-01 0.275 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.305110e-01 0.275 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.305110e-01 0.275 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.305110e-01 0.275 0 0
Muscle contraction R-HSA-397014 5.315157e-01 0.274 0 0
Basigin interactions R-HSA-210991 5.325588e-01 0.274 0 0
rRNA processing R-HSA-72312 5.426395e-01 0.265 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.444922e-01 0.264 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.444922e-01 0.264 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.444922e-01 0.264 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.444922e-01 0.264 0 0
Potential therapeutics for SARS R-HSA-9679191 5.452107e-01 0.263 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.478795e-01 0.261 0 0
Maturation of nucleoprotein R-HSA-9683610 5.478795e-01 0.261 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.478795e-01 0.261 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.478795e-01 0.261 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.540558e-01 0.256 0 0
Signaling by NOTCH1 R-HSA-1980143 5.540769e-01 0.256 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.578586e-01 0.253 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.578586e-01 0.253 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.578586e-01 0.253 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.611826e-01 0.251 0 0
Downstream signal transduction R-HSA-186763 5.659163e-01 0.247 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.694460e-01 0.245 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.729485e-01 0.242 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.729485e-01 0.242 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.785917e-01 0.238 0 0
Plus-strand DNA synthesis R-HSA-164525 5.785917e-01 0.238 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.785917e-01 0.238 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.785917e-01 0.238 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.785917e-01 0.238 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.785917e-01 0.238 0 0
Signaling by MAPK mutants R-HSA-9652817 5.785917e-01 0.238 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.785917e-01 0.238 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.785917e-01 0.238 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.785917e-01 0.238 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.785917e-01 0.238 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.785917e-01 0.238 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.785917e-01 0.238 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.785917e-01 0.238 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.785917e-01 0.238 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.785917e-01 0.238 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.785917e-01 0.238 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.785917e-01 0.238 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.787328e-01 0.238 0 0
Signal regulatory protein family interactions R-HSA-391160 5.787328e-01 0.238 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.787328e-01 0.238 0 0
DNA Damage Bypass R-HSA-73893 5.792926e-01 0.237 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.792926e-01 0.237 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.792926e-01 0.237 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.804287e-01 0.236 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.819967e-01 0.235 0 0
PCP/CE pathway R-HSA-4086400 5.819967e-01 0.235 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.823154e-01 0.235 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.823154e-01 0.235 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.823154e-01 0.235 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.823154e-01 0.235 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.823154e-01 0.235 0 0
LDL clearance R-HSA-8964038 5.823154e-01 0.235 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.848505e-01 0.233 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.851250e-01 0.233 0 0
Toll-like Receptor Cascades R-HSA-168898 5.856765e-01 0.232 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 5.867719e-01 0.232 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.960214e-01 0.225 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.960214e-01 0.225 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.961184e-01 0.225 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.005174e-01 0.221 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.005174e-01 0.221 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.005174e-01 0.221 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.005174e-01 0.221 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.005174e-01 0.221 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.048763e-01 0.218 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.048763e-01 0.218 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.048763e-01 0.218 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.058947e-01 0.218 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.058947e-01 0.218 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.058947e-01 0.218 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.058947e-01 0.218 0 0
Growth hormone receptor signaling R-HSA-982772 6.058947e-01 0.218 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.070305e-01 0.217 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.070305e-01 0.217 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.070305e-01 0.217 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.070305e-01 0.217 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.070305e-01 0.217 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.080112e-01 0.216 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.080112e-01 0.216 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.080112e-01 0.216 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.080112e-01 0.216 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.080112e-01 0.216 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.080112e-01 0.216 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.080112e-01 0.216 0 0
Formation of the anterior neural plate R-HSA-9823739 6.080112e-01 0.216 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.094293e-01 0.215 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.156085e-01 0.211 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.176684e-01 0.209 0 0
SLC transporter disorders R-HSA-5619102 6.177361e-01 0.209 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.217509e-01 0.206 0 0
Signaling by LTK in cancer R-HSA-9842640 6.217509e-01 0.206 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.217509e-01 0.206 0 0
Uncoating of the HIV Virion R-HSA-162585 6.217509e-01 0.206 0 0
MET Receptor Activation R-HSA-6806942 6.217509e-01 0.206 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.217509e-01 0.206 0 0
CREB phosphorylation R-HSA-199920 6.217509e-01 0.206 0 0
Leukotriene receptors R-HSA-391906 6.217509e-01 0.206 0 0
Nef and signal transduction R-HSA-164944 6.217509e-01 0.206 0 0
Orc1 removal from chromatin R-HSA-68949 6.283812e-01 0.202 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.285718e-01 0.202 0 0
Gastrulation R-HSA-9758941 6.289473e-01 0.201 0 0
Signaling by PDGF R-HSA-186797 6.303850e-01 0.200 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.327315e-01 0.199 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.357138e-01 0.197 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.357138e-01 0.197 0 0
Negative regulation of FLT3 R-HSA-9706369 6.357138e-01 0.197 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.357138e-01 0.197 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.456709e-01 0.190 0 0
Ca2+ pathway R-HSA-4086398 6.462437e-01 0.190 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.503309e-01 0.187 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.503309e-01 0.187 0 0
Laminin interactions R-HSA-3000157 6.503309e-01 0.187 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.503309e-01 0.187 0 0
Interleukin-7 signaling R-HSA-1266695 6.503309e-01 0.187 0 0
IGF1R signaling cascade R-HSA-2428924 6.589503e-01 0.181 0 0
Signaling by ERBB4 R-HSA-1236394 6.594669e-01 0.181 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.604922e-01 0.180 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.604922e-01 0.180 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.604922e-01 0.180 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.604922e-01 0.180 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.604922e-01 0.180 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.604922e-01 0.180 0 0
PTK6 Expression R-HSA-8849473 6.604922e-01 0.180 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.604922e-01 0.180 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.604922e-01 0.180 0 0
VLDL clearance R-HSA-8964046 6.604922e-01 0.180 0 0
Regulation of PTEN localization R-HSA-8948747 6.604922e-01 0.180 0 0
Netrin mediated repulsion signals R-HSA-418886 6.604922e-01 0.180 0 0
CHL1 interactions R-HSA-447041 6.604922e-01 0.180 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.618561e-01 0.179 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.618561e-01 0.179 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.618561e-01 0.179 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 6.618561e-01 0.179 0 0
Synthesis of PG R-HSA-1483148 6.618561e-01 0.179 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.618561e-01 0.179 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.618561e-01 0.179 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.618561e-01 0.179 0 0
Regulation of Apoptosis R-HSA-169911 6.640218e-01 0.178 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.640218e-01 0.178 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.640218e-01 0.178 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 6.640218e-01 0.178 0 0
TCR signaling R-HSA-202403 6.651746e-01 0.177 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.711643e-01 0.173 0 0
TRP channels R-HSA-3295583 6.711643e-01 0.173 0 0
Neuronal System R-HSA-112316 6.718188e-01 0.173 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.727205e-01 0.172 0 0
Cellular response to chemical stress R-HSA-9711123 6.728508e-01 0.172 0 0
Selenoamino acid metabolism R-HSA-2408522 6.772737e-01 0.169 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.817135e-01 0.166 0 0
Disease R-HSA-1643685 6.840176e-01 0.165 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.847954e-01 0.164 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.864672e-01 0.163 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.864672e-01 0.163 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.864672e-01 0.163 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.864672e-01 0.163 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.883456e-01 0.162 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.910709e-01 0.160 0 0
Cristae formation R-HSA-8949613 6.910709e-01 0.160 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.910709e-01 0.160 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.910709e-01 0.160 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.910709e-01 0.160 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.910709e-01 0.160 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.922032e-01 0.160 0 0
Diseases of DNA repair R-HSA-9675135 6.922032e-01 0.160 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.952676e-01 0.158 0 0
Minus-strand DNA synthesis R-HSA-164516 6.952676e-01 0.158 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.952676e-01 0.158 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.952676e-01 0.158 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.952676e-01 0.158 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.952676e-01 0.158 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.952676e-01 0.158 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.952676e-01 0.158 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.952676e-01 0.158 0 0
Activation of RAS in B cells R-HSA-1169092 6.952676e-01 0.158 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.952676e-01 0.158 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.952676e-01 0.158 0 0
Alpha-defensins R-HSA-1462054 6.952676e-01 0.158 0 0
Sodium/Proton exchangers R-HSA-425986 6.952676e-01 0.158 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.952676e-01 0.158 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.952676e-01 0.158 0 0
Degradation of DVL R-HSA-4641258 6.987412e-01 0.156 0 0
Collagen chain trimerization R-HSA-8948216 6.987412e-01 0.156 0 0
IRS-mediated signalling R-HSA-112399 7.022939e-01 0.153 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.067919e-01 0.151 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.072273e-01 0.150 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.095863e-01 0.149 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.095863e-01 0.149 0 0
Apoptotic factor-mediated response R-HSA-111471 7.095863e-01 0.149 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.095863e-01 0.149 0 0
Tie2 Signaling R-HSA-210993 7.095863e-01 0.149 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.100558e-01 0.149 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.100558e-01 0.149 0 0
Pyroptosis R-HSA-5620971 7.100558e-01 0.149 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.151037e-01 0.146 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.151037e-01 0.146 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.151037e-01 0.146 0 0
Dual incision in TC-NER R-HSA-6782135 7.158148e-01 0.145 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.264828e-01 0.139 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.264828e-01 0.139 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.264828e-01 0.139 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.264828e-01 0.139 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.264828e-01 0.139 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.264828e-01 0.139 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.264828e-01 0.139 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.264828e-01 0.139 0 0
Late endosomal microautophagy R-HSA-9615710 7.281294e-01 0.138 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.281294e-01 0.138 0 0
mRNA Capping R-HSA-72086 7.281294e-01 0.138 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.281294e-01 0.138 0 0
Extension of Telomeres R-HSA-180786 7.289060e-01 0.137 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.308031e-01 0.136 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.308031e-01 0.136 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.312609e-01 0.136 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.312609e-01 0.136 0 0
Crosslinking of collagen fibrils R-HSA-2243919 7.312609e-01 0.136 0 0
Translesion Synthesis by POLH R-HSA-110320 7.312609e-01 0.136 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.312609e-01 0.136 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.312609e-01 0.136 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.312609e-01 0.136 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.312609e-01 0.136 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.323920e-01 0.135 0 0
Degradation of CDH1 R-HSA-9766229 7.357113e-01 0.133 0 0
Adaptive Immune System R-HSA-1280218 7.390774e-01 0.131 0 0
DAP12 signaling R-HSA-2424491 7.453064e-01 0.128 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.458445e-01 0.127 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.515443e-01 0.124 0 0
Nephrin family interactions R-HSA-373753 7.515443e-01 0.124 0 0
Signaling by NODAL R-HSA-1181150 7.515443e-01 0.124 0 0
Protein hydroxylation R-HSA-9629569 7.515443e-01 0.124 0 0
Creatine metabolism R-HSA-71288 7.515443e-01 0.124 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.537974e-01 0.123 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.545021e-01 0.122 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.545021e-01 0.122 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.545021e-01 0.122 0 0
Regulation of CDH11 function R-HSA-9762292 7.545021e-01 0.122 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.545021e-01 0.122 0 0
Pexophagy R-HSA-9664873 7.545021e-01 0.122 0 0
Sperm Motility And Taxes R-HSA-1300642 7.545021e-01 0.122 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.602351e-01 0.119 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.616052e-01 0.118 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.616052e-01 0.118 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.621182e-01 0.118 0 0
G-protein activation R-HSA-202040 7.704939e-01 0.113 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.704939e-01 0.113 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.704939e-01 0.113 0 0
ERK/MAPK targets R-HSA-198753 7.704939e-01 0.113 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 7.704939e-01 0.113 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.739849e-01 0.111 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.745525e-01 0.111 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.750049e-01 0.111 0 0
PI Metabolism R-HSA-1483255 7.758390e-01 0.110 0 0
Signaling by WNT in cancer R-HSA-4791275 7.770474e-01 0.110 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.796526e-01 0.108 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.796526e-01 0.108 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.796526e-01 0.108 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.796526e-01 0.108 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.796526e-01 0.108 0 0
vRNP Assembly R-HSA-192905 7.796526e-01 0.108 0 0
Signaling by APC mutants R-HSA-4839744 7.796526e-01 0.108 0 0
vRNA Synthesis R-HSA-192814 7.796526e-01 0.108 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.796526e-01 0.108 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.796526e-01 0.108 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.796526e-01 0.108 0 0
Insulin receptor signalling cascade R-HSA-74751 7.879359e-01 0.104 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.881701e-01 0.103 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.881701e-01 0.103 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.881701e-01 0.103 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 7.881701e-01 0.103 0 0
Assembly Of The HIV Virion R-HSA-175474 7.881701e-01 0.103 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.916571e-01 0.101 0 0
Hemostasis R-HSA-109582 7.917929e-01 0.101 0 0
Cellular response to hypoxia R-HSA-1234174 7.984779e-01 0.098 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.022278e-01 0.096 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.022278e-01 0.096 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.022278e-01 0.096 0 0
ERKs are inactivated R-HSA-202670 8.022278e-01 0.096 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.022278e-01 0.096 0 0
Plasmalogen biosynthesis R-HSA-75896 8.022278e-01 0.096 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.022278e-01 0.096 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.022278e-01 0.096 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.022278e-01 0.096 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.046349e-01 0.094 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.046349e-01 0.094 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.046349e-01 0.094 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.054604e-01 0.094 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.054604e-01 0.094 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.054604e-01 0.094 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.086105e-01 0.092 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.097916e-01 0.092 0 0
Translation R-HSA-72766 8.112623e-01 0.091 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.184852e-01 0.087 0 0
Signal amplification R-HSA-392518 8.184852e-01 0.087 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.184852e-01 0.087 0 0
eNOS activation R-HSA-203615 8.184852e-01 0.087 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.184852e-01 0.087 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.184852e-01 0.087 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.184852e-01 0.087 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.184852e-01 0.087 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.199510e-01 0.086 0 0
Organic anion transport by SLCO transporters R-HSA-879518 8.199510e-01 0.086 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.224913e-01 0.085 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.224913e-01 0.085 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.224913e-01 0.085 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.224913e-01 0.085 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.224913e-01 0.085 0 0
Regulation of IFNG signaling R-HSA-877312 8.224913e-01 0.085 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.224913e-01 0.085 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.224913e-01 0.085 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.224913e-01 0.085 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.224913e-01 0.085 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.224913e-01 0.085 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.224913e-01 0.085 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.224913e-01 0.085 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.224913e-01 0.085 0 0
Interleukin-15 signaling R-HSA-8983432 8.224913e-01 0.085 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.228331e-01 0.085 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.228331e-01 0.085 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.228331e-01 0.085 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.228331e-01 0.085 0 0
DAG and IP3 signaling R-HSA-1489509 8.228331e-01 0.085 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.335839e-01 0.079 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.341807e-01 0.079 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.341807e-01 0.079 0 0
Complex III assembly R-HSA-9865881 8.341807e-01 0.079 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.406797e-01 0.075 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.406797e-01 0.075 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.406797e-01 0.075 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.406797e-01 0.075 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.406797e-01 0.075 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.406797e-01 0.075 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.406797e-01 0.075 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.406797e-01 0.075 0 0
Processing of SMDT1 R-HSA-8949664 8.406797e-01 0.075 0 0
Interleukin-6 signaling R-HSA-1059683 8.406797e-01 0.075 0 0
GPVI-mediated activation cascade R-HSA-114604 8.423149e-01 0.075 0 0
Calmodulin induced events R-HSA-111933 8.423149e-01 0.075 0 0
CaM pathway R-HSA-111997 8.423149e-01 0.075 0 0
Synthesis of PC R-HSA-1483191 8.437844e-01 0.074 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.473859e-01 0.072 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.473859e-01 0.072 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.473859e-01 0.072 0 0
G protein gated Potassium channels R-HSA-1296059 8.473859e-01 0.072 0 0
Tight junction interactions R-HSA-420029 8.473859e-01 0.072 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.473859e-01 0.072 0 0
Degradation of AXIN R-HSA-4641257 8.531797e-01 0.069 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.531797e-01 0.069 0 0
NCAM1 interactions R-HSA-419037 8.531797e-01 0.069 0 0
GPER1 signaling R-HSA-9634597 8.534529e-01 0.069 0 0
Gluconeogenesis R-HSA-70263 8.534529e-01 0.069 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.566554e-01 0.067 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.570054e-01 0.067 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.570054e-01 0.067 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.570054e-01 0.067 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.570054e-01 0.067 0 0
Physiological factors R-HSA-5578768 8.570054e-01 0.067 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.570054e-01 0.067 0 0
Malate-aspartate shuttle R-HSA-9856872 8.570054e-01 0.067 0 0
Zinc transporters R-HSA-435354 8.570054e-01 0.067 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.593187e-01 0.066 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.596271e-01 0.066 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.596271e-01 0.066 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.596271e-01 0.066 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.596271e-01 0.066 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.633848e-01 0.064 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.649113e-01 0.063 0 0
Collagen degradation R-HSA-1442490 8.649113e-01 0.063 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.709630e-01 0.060 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.709630e-01 0.060 0 0
Insulin processing R-HSA-264876 8.709630e-01 0.060 0 0
PI3K Cascade R-HSA-109704 8.712694e-01 0.060 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.716591e-01 0.060 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.716591e-01 0.060 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.716591e-01 0.060 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.716591e-01 0.060 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.716591e-01 0.060 0 0
Translesion synthesis by REV1 R-HSA-110312 8.716591e-01 0.060 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.716591e-01 0.060 0 0
Mitochondrial protein import R-HSA-1268020 8.727633e-01 0.059 0 0
Stabilization of p53 R-HSA-69541 8.729606e-01 0.059 0 0
RAS processing R-HSA-9648002 8.729606e-01 0.059 0 0
RSV-host interactions R-HSA-9833110 8.774613e-01 0.057 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.794555e-01 0.056 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.794555e-01 0.056 0 0
The phototransduction cascade R-HSA-2514856 8.794555e-01 0.056 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.802248e-01 0.055 0 0
Pyrimidine salvage R-HSA-73614 8.814508e-01 0.055 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.826976e-01 0.054 0 0
Translesion synthesis by POLI R-HSA-5656121 8.848118e-01 0.053 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.848118e-01 0.053 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.848118e-01 0.053 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.848118e-01 0.053 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.848118e-01 0.053 0 0
Atorvastatin ADME R-HSA-9754706 8.848118e-01 0.053 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.848118e-01 0.053 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.848118e-01 0.053 0 0
Activation of SMO R-HSA-5635838 8.848118e-01 0.053 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.848118e-01 0.053 0 0
Differentiation of T cells R-HSA-9945266 8.848118e-01 0.053 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.848118e-01 0.053 0 0
Attachment and Entry R-HSA-9678110 8.848118e-01 0.053 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.871859e-01 0.052 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.871859e-01 0.052 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.903439e-01 0.050 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.903439e-01 0.050 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.903439e-01 0.050 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.903439e-01 0.050 0 0
DARPP-32 events R-HSA-180024 8.911450e-01 0.050 0 0
Glucagon-type ligand receptors R-HSA-420092 8.911450e-01 0.050 0 0
Nucleotide biosynthesis R-HSA-8956320 8.944797e-01 0.048 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.944797e-01 0.048 0 0
Translesion synthesis by POLK R-HSA-5655862 8.966174e-01 0.047 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.966174e-01 0.047 0 0
Coenzyme A biosynthesis R-HSA-196783 8.966174e-01 0.047 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.966174e-01 0.047 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.982103e-01 0.047 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.982103e-01 0.047 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.992156e-01 0.046 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.000982e-01 0.046 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.000982e-01 0.046 0 0
Integrin cell surface interactions R-HSA-216083 9.012881e-01 0.045 0 0
ER-Phagosome pathway R-HSA-1236974 9.032490e-01 0.044 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.055646e-01 0.043 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.055646e-01 0.043 0 0
Ca-dependent events R-HSA-111996 9.055646e-01 0.043 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.068954e-01 0.042 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.072136e-01 0.042 0 0
Glycogen storage diseases R-HSA-3229121 9.072136e-01 0.042 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.072136e-01 0.042 0 0
Catecholamine biosynthesis R-HSA-209905 9.072136e-01 0.042 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.072136e-01 0.042 0 0
Choline catabolism R-HSA-6798163 9.072136e-01 0.042 0 0
Budding and maturation of HIV virion R-HSA-162588 9.083604e-01 0.042 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.083604e-01 0.042 0 0
Cargo concentration in the ER R-HSA-5694530 9.083604e-01 0.042 0 0
Regulated Necrosis R-HSA-5218859 9.121548e-01 0.040 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.124345e-01 0.040 0 0
Ion homeostasis R-HSA-5578775 9.139296e-01 0.039 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.159791e-01 0.038 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.159791e-01 0.038 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 9.159791e-01 0.038 0 0
PKA activation R-HSA-163615 9.167243e-01 0.038 0 0
PKA activation in glucagon signalling R-HSA-164378 9.167243e-01 0.038 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.167243e-01 0.038 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.167243e-01 0.038 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.188468e-01 0.037 0 0
DAP12 interactions R-HSA-2172127 9.188468e-01 0.037 0 0
Amine ligand-binding receptors R-HSA-375280 9.188468e-01 0.037 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.207087e-01 0.036 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.218510e-01 0.035 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.229994e-01 0.035 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 9.229994e-01 0.035 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.248275e-01 0.034 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.248275e-01 0.034 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.248275e-01 0.034 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.248275e-01 0.034 0 0
Somitogenesis R-HSA-9824272 9.248275e-01 0.034 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.250857e-01 0.034 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 9.252606e-01 0.034 0 0
Pyrimidine biosynthesis R-HSA-500753 9.252606e-01 0.034 0 0
Diseases of hemostasis R-HSA-9671793 9.252606e-01 0.034 0 0
Other interleukin signaling R-HSA-449836 9.252606e-01 0.034 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.252606e-01 0.034 0 0
Specification of the neural plate border R-HSA-9834899 9.252606e-01 0.034 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.252606e-01 0.034 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.252606e-01 0.034 0 0
Protein localization R-HSA-9609507 9.252857e-01 0.034 0 0
Hedgehog 'on' state R-HSA-5632684 9.274978e-01 0.033 0 0
ECM proteoglycans R-HSA-3000178 9.274978e-01 0.033 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.294639e-01 0.032 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.294639e-01 0.032 0 0
Regulation of beta-cell development R-HSA-186712 9.301149e-01 0.031 0 0
Collagen formation R-HSA-1474290 9.310251e-01 0.031 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.329224e-01 0.030 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.329224e-01 0.030 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 9.329224e-01 0.030 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 9.329224e-01 0.030 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 9.329224e-01 0.030 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 9.329224e-01 0.030 0 0
Glycogen synthesis R-HSA-3322077 9.329224e-01 0.030 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.329224e-01 0.030 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.329224e-01 0.030 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.329224e-01 0.030 0 0
Pregnenolone biosynthesis R-HSA-196108 9.329224e-01 0.030 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.329224e-01 0.030 0 0
Signaling by NOTCH2 R-HSA-1980145 9.354127e-01 0.029 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.354127e-01 0.029 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.377734e-01 0.028 0 0
PLC beta mediated events R-HSA-112043 9.393214e-01 0.027 0 0
Nucleotide salvage R-HSA-8956321 9.393214e-01 0.027 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.397992e-01 0.027 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.397992e-01 0.027 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.397992e-01 0.027 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.397992e-01 0.027 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.397992e-01 0.027 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.397992e-01 0.027 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.408837e-01 0.026 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.408837e-01 0.026 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.420874e-01 0.026 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.459121e-01 0.024 0 0
Glycosphingolipid transport R-HSA-9845576 9.459121e-01 0.024 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.459121e-01 0.024 0 0
Serine metabolism R-HSA-977347 9.459713e-01 0.024 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.459713e-01 0.024 0 0
Attachment and Entry R-HSA-9694614 9.459713e-01 0.024 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.477121e-01 0.023 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.505313e-01 0.022 0 0
Translation of Structural Proteins R-HSA-9694635 9.512108e-01 0.022 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.515109e-01 0.022 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.515109e-01 0.022 0 0
Ethanol oxidation R-HSA-71384 9.515109e-01 0.022 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.515109e-01 0.022 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.530775e-01 0.021 0 0
Purine salvage R-HSA-74217 9.547723e-01 0.020 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.547723e-01 0.020 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.564828e-01 0.019 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.564828e-01 0.019 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.564828e-01 0.019 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.564828e-01 0.019 0 0
Carnitine shuttle R-HSA-200425 9.564828e-01 0.019 0 0
Biosynthesis of maresins R-HSA-9018682 9.564828e-01 0.019 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.566064e-01 0.019 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.586639e-01 0.018 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.586639e-01 0.018 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.586639e-01 0.018 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.599209e-01 0.018 0 0
PPARA activates gene expression R-HSA-1989781 9.605484e-01 0.017 0 0
G-protein mediated events R-HSA-112040 9.606984e-01 0.017 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.609452e-01 0.017 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.609452e-01 0.017 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.609452e-01 0.017 0 0
Interleukin-6 family signaling R-HSA-6783589 9.609452e-01 0.017 0 0
Formation of the cornified envelope R-HSA-6809371 9.612241e-01 0.017 0 0
Glycogen metabolism R-HSA-8982491 9.622334e-01 0.017 0 0
Interleukin-2 family signaling R-HSA-451927 9.622334e-01 0.017 0 0
Signaling by Insulin receptor R-HSA-74752 9.632430e-01 0.016 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.634953e-01 0.016 0 0
Opioid Signalling R-HSA-111885 9.642731e-01 0.016 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.649503e-01 0.015 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.649503e-01 0.015 0 0
Hyaluronan degradation R-HSA-2160916 9.649503e-01 0.015 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.649503e-01 0.015 0 0
Fertilization R-HSA-1187000 9.649503e-01 0.015 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.649503e-01 0.015 0 0
Maturation of spike protein R-HSA-9694548 9.655058e-01 0.015 0 0
Parasitic Infection Pathways R-HSA-9824443 9.674337e-01 0.014 0 0
Leishmania infection R-HSA-9658195 9.674337e-01 0.014 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.685044e-01 0.014 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.685044e-01 0.014 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.685044e-01 0.014 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.685044e-01 0.014 0 0
Translation of Structural Proteins R-HSA-9683701 9.685044e-01 0.014 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.685448e-01 0.014 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.685448e-01 0.014 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.685448e-01 0.014 0 0
Urea cycle R-HSA-70635 9.685448e-01 0.014 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.712510e-01 0.013 0 0
Activation of GABAB receptors R-HSA-991365 9.712510e-01 0.013 0 0
GABA B receptor activation R-HSA-977444 9.712510e-01 0.013 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.717709e-01 0.012 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.717709e-01 0.012 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.717709e-01 0.012 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.717709e-01 0.012 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.733000e-01 0.012 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.737918e-01 0.012 0 0
Leishmania phagocytosis R-HSA-9664417 9.737918e-01 0.012 0 0
Parasite infection R-HSA-9664407 9.737918e-01 0.012 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.737921e-01 0.012 0 0
Stimuli-sensing channels R-HSA-2672351 9.738870e-01 0.011 0 0
Telomere Extension By Telomerase R-HSA-171319 9.746663e-01 0.011 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.746663e-01 0.011 0 0
Prednisone ADME R-HSA-9757110 9.746663e-01 0.011 0 0
Peroxisomal protein import R-HSA-9033241 9.754096e-01 0.011 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.754096e-01 0.011 0 0
Proteasome assembly R-HSA-9907900 9.760673e-01 0.011 0 0
Regulation of insulin secretion R-HSA-422356 9.768736e-01 0.010 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.772649e-01 0.010 0 0
Aquaporin-mediated transport R-HSA-445717 9.791628e-01 0.009 0 0
Neurotransmitter clearance R-HSA-112311 9.795970e-01 0.009 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.800985e-01 0.009 0 0
Downstream TCR signaling R-HSA-202424 9.816752e-01 0.008 0 0
Neurotransmitter release cycle R-HSA-112310 9.816752e-01 0.008 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.816901e-01 0.008 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.816901e-01 0.008 0 0
Phospholipid metabolism R-HSA-1483257 9.818790e-01 0.008 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.822036e-01 0.008 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.828997e-01 0.007 0 0
Metal ion SLC transporters R-HSA-425410 9.834676e-01 0.007 0 0
Integration of energy metabolism R-HSA-163685 9.838913e-01 0.007 0 0
Post-translational protein modification R-HSA-597592 9.842636e-01 0.007 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.849374e-01 0.007 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.849374e-01 0.007 0 0
Recycling of bile acids and salts R-HSA-159418 9.852544e-01 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.852544e-01 0.006 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.852732e-01 0.006 0 0
Azathioprine ADME R-HSA-9748787 9.862797e-01 0.006 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.867673e-01 0.006 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.867673e-01 0.006 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.874156e-01 0.006 0 0
Platelet homeostasis R-HSA-418346 9.875515e-01 0.005 0 0
Hyaluronan metabolism R-HSA-2142845 9.881251e-01 0.005 0 0
RA biosynthesis pathway R-HSA-5365859 9.881251e-01 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.881251e-01 0.005 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.893437e-01 0.005 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.893437e-01 0.005 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.893437e-01 0.005 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.902744e-01 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.904373e-01 0.004 0 0
Triglyceride catabolism R-HSA-163560 9.904373e-01 0.004 0 0
G alpha (q) signalling events R-HSA-416476 9.908666e-01 0.004 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.912494e-01 0.004 0 0
Voltage gated Potassium channels R-HSA-1296072 9.914187e-01 0.004 0 0
Interferon gamma signaling R-HSA-877300 9.919575e-01 0.004 0 0
Elastic fibre formation R-HSA-1566948 9.922994e-01 0.003 0 0
Biofilm formation R-HSA-9931953 9.922994e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.924778e-01 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.931000e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.937991e-01 0.003 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.937991e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.943436e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.944356e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.946669e-01 0.002 0 0
GABA receptor activation R-HSA-977443 9.946669e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.946669e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.946669e-01 0.002 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.947611e-01 0.002 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.947611e-01 0.002 0 0
ABC transporter disorders R-HSA-5619084 9.951318e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.951318e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.952328e-01 0.002 0 0
Mitochondrial protein degradation R-HSA-9837999 9.959552e-01 0.002 0 0
Defensins R-HSA-1461973 9.959795e-01 0.002 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.963500e-01 0.002 0 0
Ion transport by P-type ATPases R-HSA-936837 9.963643e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.963923e-01 0.002 0 0
Methylation R-HSA-156581 9.963923e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.963923e-01 0.002 0 0
Neddylation R-HSA-8951664 9.964100e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.965962e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.968676e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.978067e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.978361e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.979631e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.979631e-01 0.001 0 0
Pyruvate metabolism R-HSA-70268 9.979946e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.980440e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.981515e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.983104e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.983227e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.984295e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.984688e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.985403e-01 0.001 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.985760e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.986489e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.987480e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.987480e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.989048e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.989340e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.990174e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.990664e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.991183e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.991183e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.991536e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.992598e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.992902e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.993379e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.993632e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.994286e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.994379e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.995401e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.995873e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.996009e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997020e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997020e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997020e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.997326e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.997544e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998069e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998153e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998263e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998446e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998446e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.998812e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998949e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.998990e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999017e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999348e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999550e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999620e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999620e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999694e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999808e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999854e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999872e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999873e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999873e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999874e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999879e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999908e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999945e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999984e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999988e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999993e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999998e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways